Using Atmospheric Circulation Patterns to Detect and Attribute Changes in the Risk of Extreme Climate Events

NASA Astrophysics Data System (ADS)

Diffenbaugh, N. S.; Horton, D. E.; Singh, D.; Swain, D. L.; Touma, D. E.; Mankin, J. S.

2015-12-01

Because of the high cost of extreme events and the growing evidence that global warming is likely to alter the statistical distribution of climate variables, detection and attribution of changes in the probability of extreme climate events has become a pressing topic for the scientific community, elected officials, and the public. While most of the emphasis has thus far focused on analyzing the climate variable of interest (most often temperature or precipitation, but also flooding and drought), there is an emerging emphasis on applying detection and attribution analysis techniques to the underlying physical causes of individual extreme events. This approach is promising in part because the underlying physical causes (such as atmospheric circulation patterns) can in some cases be more accurately represented in climate models than the more proximal climate variable (such as precipitation). In addition, and more scientifically critical, is the fact that the most extreme events result from a rare combination of interacting causes, often referred to as "ingredients". Rare events will therefore always have a strong influence of "natural" variability. Analyzing the underlying physical mechanisms can therefore help to test whether there have been changes in the probability of the constituent conditions of an individual event, or whether the co-occurrence of causal conditions cannot be distinguished from random chance. This presentation will review approaches to applying detection/attribution analysis to the underlying physical causes of extreme events (including both "thermodynamic" and "dynamic" causes), and provide a number of case studies, including the role of frequency of atmospheric circulation patterns in the probability of hot, cold, wet and dry events.

More frequent showers and thunderstorms under a warming climate: evidence observed in Northern Eurasia

NASA Astrophysics Data System (ADS)

Ye, H.; Fetzer, E. J.; Wong, S.; Lambrigtsen, B.; Wang, T.; Chen, L. L.; Von, D.

2015-12-01

This study uses historical records of synoptic observations over northern Eurasia to examine changing frequency of precipitation associated with large synoptic events versus convective and thunderstorm activities. We found days associated with showers and precipitation accompanied by thunderstorms have been increasing in general during the study period of 1966-2000 while the total wet day frequency has been decreasing in all seasons. This study suggests increasing convective and severe weather-related precipitation events may be a significant contributor to higher intensity and more extreme precipitation under a warming climate.

Size Distributions of Solar Proton Events: Methodological and Physical Restrictions

NASA Astrophysics Data System (ADS)

Miroshnichenko, L. I.; Yanke, V. G.

2016-12-01

Based on the new catalogue of solar proton events (SPEs) for the period of 1997 - 2009 (Solar Cycle 23) we revisit the long-studied problem of the event-size distributions in the context of those constructed for other solar-flare parameters. Recent results on the problem of size distributions of solar flares and proton events are briefly reviewed. Even a cursory acquaintance with this research field reveals a rather mixed and controversial picture. We concentrate on three main issues: i) SPE size distribution for {>} 10 MeV protons in Solar Cycle 23; ii) size distribution of {>} 1 GV proton events in 1942 - 2014; iii) variations of annual numbers for {>} 10 MeV proton events on long time scales (1955 - 2015). Different results are critically compared; most of the studies in this field are shown to suffer from vastly different input datasets as well as from insufficient knowledge of underlying physical processes in the SPEs under consideration. New studies in this field should be made on more distinct physical and methodological bases. It is important to note the evident similarity in size distributions of solar flares and superflares in Sun-like stars.

Stochastic generation of hourly rainstorm events in Johor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nojumuddin, Nur Syereena; Yusof, Fadhilah; Yusop, Zulkifli

2015-02-03

Engineers and researchers in water-related studies are often faced with the problem of having insufficient and long rainfall record. Practical and effective methods must be developed to generate unavailable data from limited available data. Therefore, this paper presents a Monte-Carlo based stochastic hourly rainfall generation model to complement the unavailable data. The Monte Carlo simulation used in this study is based on the best fit of storm characteristics. Hence, by using the Maximum Likelihood Estimation (MLE) and Anderson Darling goodness-of-fit test, lognormal appeared to be the best rainfall distribution. Therefore, the Monte Carlo simulation based on lognormal distribution was usedmore » in the study. The proposed model was verified by comparing the statistical moments of rainstorm characteristics from the combination of the observed rainstorm events under 10 years and simulated rainstorm events under 30 years of rainfall records with those under the entire 40 years of observed rainfall data based on the hourly rainfall data at the station J1 in Johor over the period of 1972–2011. The absolute percentage error of the duration-depth, duration-inter-event time and depth-inter-event time will be used as the accuracy test. The results showed the first four product-moments of the observed rainstorm characteristics were close with the simulated rainstorm characteristics. The proposed model can be used as a basis to derive rainfall intensity-duration frequency in Johor.« less

Life events and hopelessness depression: The influence of affective experience

PubMed Central

Chen, Jian

2017-01-01

This study explored the association of the affective experience (AE) of life events on hopelessness depression (HD). Undergraduates (N = 301) participating in a 12-week prospective study completed measures of HD, cognitive style, and psychological stress. The results indicate AE is an underlying mechanism influencing the longitudinal link between life events and HD. Negative life events with clear negative AE directly promoted the development of HD. Positive life events with clear positive AE directly impeded the development of HD. Neutral life events with mixed AE directly and interacting with negative cognitive style promoted the development of HD. The results should increase understanding of the hopelessness theory of depression, and suggest that neutral life events should be important elements in depression therapy. PMID:29176863

A Bayes linear Bayes method for estimation of correlated event rates.

PubMed

Quigley, John; Wilson, Kevin J; Walls, Lesley; Bedford, Tim

2013-12-01

Typically, full Bayesian estimation of correlated event rates can be computationally challenging since estimators are intractable. When estimation of event rates represents one activity within a larger modeling process, there is an incentive to develop more efficient inference than provided by a full Bayesian model. We develop a new subjective inference method for correlated event rates based on a Bayes linear Bayes model under the assumption that events are generated from a homogeneous Poisson process. To reduce the elicitation burden we introduce homogenization factors to the model and, as an alternative to a subjective prior, an empirical method using the method of moments is developed. Inference under the new method is compared against estimates obtained under a full Bayesian model, which takes a multivariate gamma prior, where the predictive and posterior distributions are derived in terms of well-known functions. The mathematical properties of both models are presented. A simulation study shows that the Bayes linear Bayes inference method and the full Bayesian model provide equally reliable estimates. An illustrative example, motivated by a problem of estimating correlated event rates across different users in a simple supply chain, shows how ignoring the correlation leads to biased estimation of event rates. © 2013 Society for Risk Analysis.

Modeling Anti-Air Warfare With Discrete Event Simulation and Analyzing Naval Convoy Operations

DTIC Science & Technology

2016-06-01

WARFARE WITH DISCRETE EVENT SIMULATION AND ANALYZING NAVAL CONVOY OPERATIONS by Ali E. Opcin June 2016 Thesis Advisor: Arnold H. Buss Co...REPORT DATE June 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE MODELING ANTI-AIR WARFARE WITH DISCRETE EVENT...In this study, a discrete event simulation (DES) was built by modeling ships, and their sensors and weapons, to simulate convoy operations under

A Review of Recent Advances in Research on Extreme Heat Events

NASA Technical Reports Server (NTRS)

Horton, Radley M.; Mankin, Justin S.; Lesk, Corey; Coffel, Ethan; Raymond, Colin

2016-01-01

Reviewing recent literature, we report that changes in extreme heat event characteristics such as magnitude, frequency, and duration are highly sensitive to changes in mean global-scale warming. Numerous studies have detected significant changes in the observed occurrence of extreme heat events, irrespective of how such events are defined. Further, a number of these studies have attributed present-day changes in the risk of individual heat events and the documented global-scale increase in such events to anthropogenic-driven warming. Advances in process-based studies of heat events have focused on the proximate land-atmosphere interactions through soil moisture anomalies, and changes in occurrence of the underlying atmospheric circulation associated with heat events in the mid-latitudes. While evidence for a number of hypotheses remains limited, climate change nevertheless points to tail risks of possible changes in heat extremes that could exceed estimates generated from model outputs of mean temperature. We also explore risks associated with compound extreme events and nonlinear impacts associated with extreme heat.

Preliminary study of visual perspective in mental time travel in schizophrenia.

PubMed

Wang, Ya; Wang, Yi; Zhao, Qing; Cui, Ji-Fang; Hong, Xiao-Hong; Chan, Raymond Ck

2017-10-01

This study explored specificity and visual perspective of mental time travel in schizophrenia. Fifteen patients with schizophrenia and 18 controls were recruited. Participants were asked to recall or imagine specific events according to cue words. Results showed that schizophrenia patients generated fewer specific events than controls, the recalled events were more specific than imagined events. Schizophrenia adopted less field perspective and more observer perspective than controls. These results suggested that patients with schizophrenia were impaired in mental time travel both in specificity and visual perspective. Further studies are needed to identify the underlying mechanisms. Copyright © 2017 Elsevier B.V. All rights reserved.

Future changes of precipitation characteristics in China

NASA Astrophysics Data System (ADS)

Wu, S.; Wu, Y.; Wen, J.

2017-12-01

Global warming has the potential to alter the hydrological cycle, with significant impacts on the human society, the environment and ecosystems. This study provides a detailed assessment of potential changes in precipitation characteristics in China using a suite of 12 high-resolution CMIP5 climate models under a medium and a high Representative Concentration Pathways: RCP4.5 and RCP8.5. We examine future changes over the entire distribution of precipitation, and identify any shift in the shape and/or scale of the distribution. In addition, we use extreme-value theory to evaluate the change in probability and magnitude for extreme precipitation events. Overall, China is going to experience an increase in total precipitation (by 8% under RCP4.5 and 12% under RCP8.5). This increase is uneven spatially, with more increase in the west and less increase in the east. Precipitation frequency is projected to increase in the west and decrease in the east. Under RCP4.5, the overall precipitation frequency for the entire China remains largely unchanged (0.08%). However, RCP8.5 projects a more significant decrease in frequency for large part of China, resulting in an overall decrease of 2.08%. Precipitation intensity is likely increase more uniformly, with an overall increase of 11% for RCP4.5 and 19% for RCP8.5. Precipitation increases for all parts of the distribution, but the increase is more for higher quantiles, i.e. strong events. The relative contribution of small quantiles is likely to decrease, whereas contribution from heavy events is likely to increase. Extreme precipitation increase at much higher rates than average precipitation, and high rates of increase are expected for more extreme events. 1-year events are likely to increase by 15%, but 20-year events are going to increase by 21% under RCP4.5, 26% and 40% respectively under RCP8.5. The increase of extreme events is likely to be more spatially uniform.

The safety of influenza vaccines in children: An Institute for Vaccine Safety white paper.

PubMed

Halsey, Neal A; Talaat, Kawsar R; Greenbaum, Adena; Mensah, Eric; Dudley, Matthew Z; Proveaux, Tina; Salmon, Daniel A

2015-12-30

Most influenza vaccines are generally safe, but influenza vaccines can cause rare serious adverse events. Some adverse events, such as fever and febrile seizures, are more common in children than adults. There can be differences in the safety of vaccines in different populations due to underlying differences in genetic predisposition to the adverse event. Live attenuated vaccines have not been studied adequately in children under 2 years of age to determine the risks of adverse events; more studies are needed to address this and several other priority safety issues with all influenza vaccines in children. All vaccines intended for use in children require safety testing in the target age group, especially in young children. Safety of one influenza vaccine in children should not be extrapolated to assumed safety of all influenza vaccines in children. The low rates of adverse events from influenza vaccines should not be a deterrent to the use of influenza vaccines because of the overwhelming evidence of the burden of disease due to influenza in children. Copyright © 2016. Published by Elsevier Ltd.

Cognitive load and task condition in event- and time-based prospective memory: an experimental investigation.

PubMed

Khan, Azizuddin; Sharma, Narendra K; Dixit, Shikha

2008-09-01

Prospective memory is memory for the realization of delayed intention. Researchers distinguish 2 kinds of prospective memory: event- and time-based (G. O. Einstein & M. A. McDaniel, 1990). Taking that distinction into account, the present authors explored participants' comparative performance under event- and time-based tasks. In an experimental study of 80 participants, the authors investigated the roles of cognitive load and task condition in prospective memory. Cognitive load (low vs. high) and task condition (event- vs. time-based task) were the independent variables. Accuracy in prospective memory was the dependent variable. Results showed significant differential effects under event- and time-based tasks. However, the effect of cognitive load was more detrimental in time-based prospective memory. Results also revealed that time monitoring is critical in successful performance of time estimation and so in time-based prospective memory. Similarly, participants' better performance on the event-based prospective memory task showed that they acted on the basis of environment cues. Event-based prospective memory was environmentally cued; time-based prospective memory required self-initiation.

33 CFR 100.30 - Approval required for holding event.

Code of Federal Regulations, 2013 CFR

2013-07-01

... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...

33 CFR 100.30 - Approval required for holding event.

Code of Federal Regulations, 2012 CFR

2012-07-01

... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...

33 CFR 100.30 - Approval required for holding event.

Code of Federal Regulations, 2011 CFR

2011-07-01

... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...

33 CFR 100.30 - Approval required for holding event.

Code of Federal Regulations, 2014 CFR

2014-07-01

... event. 100.30 Section 100.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... holding event. (a) An event for which application is required under § 100.15(a) shall be held only after approval of such event by the District Commander, except that applications referred to a State under § 100...

Cognitive Association Formation in Episodic Memory: Evidence from Event-Related Potentials

ERIC Educational Resources Information Center

Kim, Alice S. N.; Vallesi, Antonino; Picton, Terence W.; Tulving, Endel

2009-01-01

The present study focused on the processes underlying cognitive association formation by investigating subsequent memory effects. Event-related potentials were recorded as participants studied pairs of words, presented one word at a time, for later recall. The findings showed that a frontal-positive late wave (LW), which occurred 1-1.6 s after the…

Preventable in-hospital medical injury under the "no fault" system in New Zealand

PubMed Central

Davis, P; Lay-Yee, R; Briant, R; Scott, A

2003-01-01

Objectives: To describe the pattern of preventable in-hospital medical injury under the "no fault" system and to assess the level of serious preventable patient harm. Design: Cross sectional survey using a two stage retrospective assessment of medical records conducted by structured implicit review. Setting: General hospitals with over 100 beds providing acute care in New Zealand. Participants: A sample of 6579 patients admitted in 1998 to 13 hospitals selected by stratified systematic list sample. Main outcome measures: Occurrence, preventability, and impact of adverse events. Results: Over 5% of admissions were associated with a preventable in-hospital event, of which nearly half had an element of systems failure. The elderly, ethnic minority groups, and particular clinical areas were at higher risk. The chances of a patient experiencing a serious preventable adverse event subsequent to hospital admission were just under 1%, a figure close to published results from comparable studies under tort. On average, these events required an additional 4 weeks in hospital. System related issues of protocol use and development, communication, and organisation, as well as requirements for consultation and education, were pre-eminent. Conclusions: The risk of serious preventable in-hospital medical injury for patients in New Zealand, a well established "no fault" jurisdiction, is within the range reported in comparable investigations under tort. PMID:12897357

Preliminary results of the FVS gypsy moth event monitor using remeasurement plot data from Northern West Virginia

Treesearch

Matthew P. Perkowski; John R. Brooks; Kurt W. Gottschalk

2008-01-01

Predictions based on the Gypsy Moth Event Monitor were compared to remeasurement plot data from stands receiving gypsy moth defoliation. These stands were part of a silvicultural treatment study located in northern West Virginia that included a sanitation thinning, a presalvage thinning and paired no-treatment controls. In all cases the event monitor under predicted...

Personality and Life Events as Predictors of Adolescents' Life Satisfaction: Do Life Events Mediate the Link between Personality and Life Satisfaction?

ERIC Educational Resources Information Center

Ho, Man Yee; Cheung, Fanny M.; Cheung, Shu Fai

2008-01-01

This study examined the association among personality traits, life events and life satisfaction, and the underlying pathways from personality traits to life satisfaction. A total of 1,961 adolescents were recruited from 21 secondary schools in Hong Kong. The adolescent version of the Chinese Personality Assessment Inventory (CPAI-A), the Chinese…

26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.

Code of Federal Regulations, 2014 CFR

2014-04-01

... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...

26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.

Code of Federal Regulations, 2013 CFR

2013-04-01

... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...

26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.

Code of Federal Regulations, 2011 CFR

2011-04-01

... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...

26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.

Code of Federal Regulations, 2010 CFR

2010-04-01

... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...

26 CFR 54.4980B-10 - Interaction of FMLA and COBRA.

Code of Federal Regulations, 2012 CFR

2012-04-01

... following questions-and-answers address how the taking of leave under the Family and Medical Leave Act of... circumstances does a qualifying event occur if an employee does not return from leave taken under FMLA? A-1: (a) The taking of leave under FMLA does not constitute a qualifying event. A qualifying event under Q&A-1...

United States Temperature and Precipitation Extremes: Phenomenology, Large-Scale Organization, Physical Mechanisms and Model Representation

NASA Astrophysics Data System (ADS)

Black, R. X.

2017-12-01

We summarize results from a project focusing on regional temperature and precipitation extremes over the continental United States. Our project introduces a new framework for evaluating these extremes emphasizing their (a) large-scale organization, (b) underlying physical sources (including remote-excitation and scale-interaction) and (c) representation in climate models. Results to be reported include the synoptic-dynamic behavior, seasonality and secular variability of cold waves, dry spells and heavy rainfall events in the observational record. We also study how the characteristics of such extremes are systematically related to Northern Hemisphere planetary wave structures and thus planetary- and hemispheric-scale forcing (e.g., those associated with major El Nino events and Arctic sea ice change). The underlying physics of event onset are diagnostically quantified for different categories of events. Finally, the representation of these extremes in historical coupled climate model simulations is studied and the origins of model biases are traced using new metrics designed to assess the large-scale atmospheric forcing of local extremes.

Interactions Between Depression and Lower Urinary Tract Symptoms: The Role of Adverse Life Events and Inflammatory Mechanisms. Results From the European Male Ageing Study.

PubMed

Castellini, Giovanni; Wu, Frederick C W; Finn, Joseph D; OʼNeill, Terrence W; Lean, Michael E J; Pendleton, Neil; Rastrelli, Giulia; Rutter, Martin K; Gacci, Mauro; Ricca, Valdo; Maggi, Mario

2016-01-01

Depression and lower urinary tract symptoms (LUTSs) have been found to co-occur among aging men. The present study attempted to clarify the nature of this relationship, considering adverse life events as potential moderators and the inflammation as an underlying biological mechanism. The relationship between depression and LUTS was evaluated using data from the European Male Ageing Study, the largest multicenter population-based study of aging in European men. The sample included 3369 men who were assessed by means of several self-reported questionnaires, including the Beck Depression Inventory-II, the International Prostate Symptom Score, and the Adverse Life Events Scale. Participants were asked to provide information regarding general health and life-style, and medical comorbidities. Biological measures including prostate-specific antigen, testosterone, and C-reactive protein were measured. LUTS and depressive symptoms were correlated (R = 0.32, β = .10, p < .001), even after adjusting for life-style, psychological, and medical variables. A history of adverse life events was associated with both higher LUTS and Beck Depression Inventory scores. Furthermore, adverse life events moderated the LUTS-depression association (F = 22.62, b = 0.061, p < .001), which increased as a function of the number of life events. C-reactive protein was found to mediate the LUTS-depression association. This mediation effect was moderated by number of adverse life events. Participants with a history of adverse life events represent a vulnerable population in whom the association between somatic and depressive symptoms is stronger. One of the biological mechanisms underlying this association could be an activation of the central inflammatory signaling pathways.

Common and Segregated Neural Substrates for Automatic Conceptual and Affective Priming as Revealed by Event-Related Functional Magnetic Resonance Imaging

ERIC Educational Resources Information Center

Liu, Hongyan; Hu, Zhiguo; Peng, Danling; Yang, Yanhui; Li, Kuncheng

2010-01-01

The brain activity associated with automatic semantic priming has been extensively studied. Thus far there has been no prior study that directly contrasts the neural mechanisms of semantic and affective priming. The present study employed event-related fMRI to examine the common and distinct neural bases underlying conceptual and affective priming…

Event rate and reaction time performance in ADHD: Testing predictions from the state regulation deficit hypothesis using an ex-Gaussian model.

PubMed

Metin, Baris; Wiersema, Jan R; Verguts, Tom; Gasthuys, Roos; van Der Meere, Jacob J; Roeyers, Herbert; Sonuga-Barke, Edmund

2016-01-01

According to the state regulation deficit (SRD) account, ADHD is associated with a problem using effort to maintain an optimal activation state under demanding task settings such as very fast or very slow event rates. This leads to a prediction of disrupted performance at event rate extremes reflected in higher Gaussian response variability that is a putative marker of activation during motor preparation. In the current study, we tested this hypothesis using ex-Gaussian modeling, which distinguishes Gaussian from non-Gaussian variability. Twenty-five children with ADHD and 29 typically developing controls performed a simple Go/No-Go task under four different event-rate conditions. There was an accentuated quadratic relationship between event rate and Gaussian variability in the ADHD group compared to the controls. The children with ADHD had greater Gaussian variability at very fast and very slow event rates but not at moderate event rates. The results provide evidence for the SRD account of ADHD. However, given that this effect did not explain all group differences (some of which were independent of event rate) other cognitive and/or motivational processes are also likely implicated in ADHD performance deficits.

Stressful Life Events as a Predictor for Nonsuicidal Self-Injury in Southern Chinese Adolescence: A Cross-Sectional Study.

PubMed

Tang, Jie; Yang, Wei; Ahmed, Niman Isse; Ma, Ying; Liu, Hui-Yan; Wang, Jia-Ji; Wang, Pei-Xi; Du, Yu-Kai; Yu, Yi-Zhen

2016-03-01

Stressful life events have been implicated in the etiology of kinds of psychopathology related to nonsuicidal self-injury (NSSI); however, few studies have examined the association between NSSI and stressful life events directly in Chinese school adolescents. In this study, we aim to estimate the prevalence rate of NSSI and examine its association with stressful life events in Southern Chinese adolescents. A total sample of 4405 students with age ranged from 10 to 22 years was randomly selected from 12 schools in 3 cities of Guangdong Province, China. NSSI, stressful life events, self-esteem, emotional management, and coping methods were measured by structured questionnaires. Multinomial logistic regression was used to examine the association of NSSI with stressful life events. Results showed the 1 year self-reported NSSI was 29.2%, with 22.6% engaged in "minor" NSSI (including hitting self, pulling hair, biting self, inserting objects under nails or skin, picking at a wound) and 6.6% in "moderate/sever" NSSI (including cutting/carving, burning, self-tattooing, scraping, and erasing skin). Self-hitting (15.9%), pulling hair out (10.9%), and self-inserting objects under nails or skin picking areas to dram blood (18.3%) were the most frequent types of NSSI among adolescents. Results also showed that "Minor NSSI" was associated with stressful life events on interpersonal, loss and health adaption, and "moderate/severe NSSI" was associated with life events on interpersonal, health adaption in Southern Chinese adolescents, even after adjusted for sex, age, residence, self-esteem, coping style, and emotional management. Results further suggested stressful life events were significantly associated with less risk of NSSI in those who had good emotional management ability.

CRISPR-directed mitotic recombination enables genetic mapping without crosses.

PubMed

Sadhu, Meru J; Bloom, Joshua S; Day, Laura; Kruglyak, Leonid

2016-05-27

Linkage and association studies have mapped thousands of genomic regions that contribute to phenotypic variation, but narrowing these regions to the underlying causal genes and variants has proven much more challenging. Resolution of genetic mapping is limited by the recombination rate. We developed a method that uses CRISPR (clustered, regularly interspaced, short palindromic repeats) to build mapping panels with targeted recombination events. We tested the method by generating a panel with recombination events spaced along a yeast chromosome arm, mapping trait variation, and then targeting a high density of recombination events to the region of interest. Using this approach, we fine-mapped manganese sensitivity to a single polymorphism in the transporter Pmr1. Targeting recombination events to regions of interest allows us to rapidly and systematically identify causal variants underlying trait differences. Copyright © 2016, American Association for the Advancement of Science.

Soil organic carbon loss and selective transportation under field simulated rainfall events.

PubMed

Nie, Xiaodong; Li, Zhongwu; Huang, Jinquan; Huang, Bin; Zhang, Yan; Ma, Wenming; Hu, Yanbiao; Zeng, Guangming

2014-01-01

The study on the lateral movement of soil organic carbon (SOC) during soil erosion can improve the understanding of global carbon budget. Simulated rainfall experiments on small field plots were conducted to investigate the SOC lateral movement under different rainfall intensities and tillage practices. Two rainfall intensities (High intensity (HI) and Low intensity (LI)) and two tillage practices (No tillage (NT) and Conventional tillage (CT)) were maintained on three plots (2 m width × 5 m length): HI-NT, LI-NT and LI-CT. The rainfall lasted 60 minutes after the runoff generated, the sediment yield and runoff volume were measured and sampled at 6-min intervals. SOC concentration of sediment and runoff as well as the sediment particle size distribution were measured. The results showed that most of the eroded organic carbon (OC) was lost in form of sediment-bound organic carbon in all events. The amount of lost SOC in LI-NT event was 12.76 times greater than that in LI-CT event, whereas this measure in HI-NT event was 3.25 times greater than that in LI-NT event. These results suggest that conventional tillage as well as lower rainfall intensity can reduce the amount of lost SOC during short-term soil erosion. Meanwhile, the eroded sediment in all events was enriched in OC, and higher enrichment ratio of OC (ERoc) in sediment was observed in LI events than that in HI event, whereas similar ERoc curves were found in LI-CT and LI-NT events. Furthermore, significant correlations between ERoc and different size sediment particles were only observed in HI-NT event. This indicates that the enrichment of OC is dependent on the erosion process, and the specific enrichment mechanisms with respect to different erosion processes should be studied in future.

Soil Organic Carbon Loss and Selective Transportation under Field Simulated Rainfall Events

PubMed Central

Nie, Xiaodong; Li, Zhongwu; Huang, Jinquan; Huang, Bin; Zhang, Yan; Ma, Wenming; Hu, Yanbiao; Zeng, Guangming

2014-01-01

The study on the lateral movement of soil organic carbon (SOC) during soil erosion can improve the understanding of global carbon budget. Simulated rainfall experiments on small field plots were conducted to investigate the SOC lateral movement under different rainfall intensities and tillage practices. Two rainfall intensities (High intensity (HI) and Low intensity (LI)) and two tillage practices (No tillage (NT) and Conventional tillage (CT)) were maintained on three plots (2 m width × 5 m length): HI-NT, LI-NT and LI-CT. The rainfall lasted 60 minutes after the runoff generated, the sediment yield and runoff volume were measured and sampled at 6-min intervals. SOC concentration of sediment and runoff as well as the sediment particle size distribution were measured. The results showed that most of the eroded organic carbon (OC) was lost in form of sediment-bound organic carbon in all events. The amount of lost SOC in LI-NT event was 12.76 times greater than that in LI-CT event, whereas this measure in HI-NT event was 3.25 times greater than that in LI-NT event. These results suggest that conventional tillage as well as lower rainfall intensity can reduce the amount of lost SOC during short-term soil erosion. Meanwhile, the eroded sediment in all events was enriched in OC, and higher enrichment ratio of OC (ERoc) in sediment was observed in LI events than that in HI event, whereas similar ERoc curves were found in LI-CT and LI-NT events. Furthermore, significant correlations between ERoc and different size sediment particles were only observed in HI-NT event. This indicates that the enrichment of OC is dependent on the erosion process, and the specific enrichment mechanisms with respect to different erosion processes should be studied in future. PMID:25166015

Acoustic emission study of deformation behavior of nacre

NASA Astrophysics Data System (ADS)

Luo, Shunfei; Luo, Hongyun; Han, Zhiyuan

2016-02-01

A study on the acoustic emission (AE) characteristics during deformation of nacre material was performed. We found that intermittent AE events are generated during nacre deformation. These avalanches may be attributed to microfracture events of the aragonite (CaCO3) nano-asperities and bridges during tablet sliding. These events show several critical features, such as the power-law distributions of the avalanche sizes and interval. These results suggest that the underlying fracture dynamics during nacre deformation display a self-organized criticality (SOC). The results also imply that the disorder and long-range correlation between local microfracture events may play important roles in nacre deformation.

Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.

PubMed

Kansui, Yasuo; Garland, Christopher J; Dora, Kim A

2008-08-01

Increases in global Ca(2+) in the endothelium are a crucial step in releasing relaxing factors to modulate arterial tone. In the present study we investigated spontaneous Ca(2+) events in endothelial cells, and the contribution of smooth muscle cells to these Ca(2+) events, in pressurized rat mesenteric resistance arteries. Spontaneous Ca(2+) events were observed under resting conditions in 34% of cells. These Ca(2+) events were absent in arteries preincubated with either cyclopiazonic acid or U-73122, but were unaffected by ryanodine or nicotinamide. Stimulation of smooth muscle cell depolarization and contraction with either phenylephrine or high concentrations of KCl significantly increased the frequency of endothelial cell Ca(2+) events. The putative gap junction uncouplers carbenoxolone and 18alpha-glycyrrhetinic acid each inhibited spontaneous and evoked Ca(2+) events, and the movement of calcein from endothelial to smooth muscle cells. In addition, spontaneous Ca(2+) events were diminished by nifedipine, lowering extracellular Ca(2+) levels, or by blockers of non-selective Ca(2+) influx pathways. These findings suggest that in pressurized rat mesenteric arteries, spontaneous Ca(2+) events in the endothelial cells appear to originate from endoplasmic reticulum IP(3) receptors, and are subject to regulation by surrounding smooth muscle cells via myoendothelial gap junctions, even under basal conditions.

Ergonomics perspective for identifying and reducing internal operative flow disruption for laparoscopic urological surgery.

PubMed

Al-Hakim, Latif; Xiao, Jiaquan; Sengupta, Shomik

2017-12-01

The aim of this study is to examine operative flow disruption that occurs inside the surgical field, (internal operative flow disruption (OFD)), during urological laparoscopies, and to relate those events to external ergonomics environment in terms of monitor location, level of instruments' handles, and location of surgical team members. According to the our best knowledge, this is the first study of its kind. A combination of real and video-aided observational study was conducted in the operating rooms at hospitals in Australia and China. Brain storming sessions were first conducted to identify the main internal OFD events, and the observable reasons, potential external, and latent ergonomic factors were listed. A prospective observational study was then conducted. The observer's records and the related video records of internal surgical fields were analysed. Procedures were categorised into groups based on similarity in ergonomics environment. The mapping process revealed 39 types of internal OFD events resulted from six reasons. A total of 24 procedures were selected and arranged into two groups, each with twelve procedures. Group A was carried out under satisfactory ergonomics environment, while Group B was conducted under unsatisfactory ergonomics environment. A total of 1178 OFD events were detected delaying the total observed operative times (2966 min) by 220 min (7.43%). Average OFD/h in group A was less than 15, while in group B about 29 OFD/h. There are two main latent ergonomics factors affecting the surgeon's performance; non-physiological posture and long-period static posture. The delays and number of internal OFD were nearly doubled where procedures were conducted under unsatisfactory external ergonomics environment. Some events such as stopping operation and irrelevant conversations during long procedures may have a positive influence on the surgeon's performance.

The Effect of Interruptions on Part 121 Air Carrier Operations

NASA Technical Reports Server (NTRS)

Damos, Diane L.

1998-01-01

The primary purpose of this study was to determine the relative priorities of various events and activities by examining the probability that a given activity was interrupted by a given event. The analysis will begin by providing frequency of interruption data by crew position (captain versus first officer) and event type. Any differences in the pattern of interruptions between the first officers and the captains will be explored and interpreted in terms of standard operating procedures. Subsequent data analyses will focus on comparing the frequency of interruptions for different types of activities and for the same activities under normal versus emergency conditions. Briefings and checklists will receive particular attention. The frequency with which specific activities are interrupted under multiple- versus single-task conditions also will be examined; because the majority of multiple-task data were obtained under laboratory conditions, LOFT-type tapes offer a unique opportunity to examine concurrent task performance under 'real-world' conditions. A second purpose of this study is to examine the effects of the interruptions on performance. More specifically, when possible, the time to resume specific activities will be compared to determine if pilots are slower to resume certain types of activities. Errors in resumption or failures to resume specific activities will be noted and any patterns in these errors will be identified. Again, particular attention will be given to the effects of interruptions on the completion of checklists and briefings. Other types of errors and missed events (i.e., the crew should have responded to the event but did not) will be examined. Any methodology using interruptions to examine task prioritization must be able to identify when an interruption has occurred and describe the ongoing activities that were interrupted. Both of these methodological problems are discussed In detail in the following section,

A modelling study of the event-based retention performance of green roof under the hot-humid tropical climate in Kuching.

PubMed

Chai, C T; Putuhena, F J; Selaman, O S

2017-12-01

The influences of climate on the retention capability of green roof have been widely discussed in existing literature. However, knowledge on how the retention capability of green roof is affected by the tropical climate is limited. This paper highlights the retention performance of the green roof situated in Kuching under hot-humid tropical climatic conditions. Using the green roof water balance modelling approach, this study simulated the hourly runoff generated from a virtual green roof from November 2012 to October 2013 based on past meteorological data. The result showed that the overall retention performance was satisfactory with a mean retention rate of 72.5% from 380 analysed rainfall events but reduced to 12.0% only for the events that potentially trigger the occurrence of flash flood. By performing the Spearman rank's correlation analysis, it was found that the rainfall depth and mean rainfall intensity, individually, had a strong negative correlation with event retention rate, suggesting that the retention rate increases with decreased rainfall depth. The expected direct relationship between retention rate and antecedent dry weather period was found to be event size dependent.

Network rigidity and properties of SiO2 and GeO2 glasses under pressure.

PubMed

Trachenko, Kostya; Dove, Martin T; Brazhkin, Vadim; El'kin, F S

2004-09-24

We report in situ studies of SiO2 glass under pressure and find that temperature-induced densification takes place in a pressure window. To explain this effect, we study how rigidity of glasses changes under pressure, with rigidity percolation affecting the dynamics of local relaxation events. We link rigidity percolation in glasses to other effects, including a large increase of crystallization temperature and logarithmic relaxation under pressure.

ATLAS Simulation using Real Data: Embedding and Overlay

NASA Astrophysics Data System (ADS)

Haas, Andrew; ATLAS Collaboration

2017-10-01

For some physics processes studied with the ATLAS detector, a more accurate simulation in some respects can be achieved by including real data into simulated events, with substantial potential improvements in the CPU, disk space, and memory usage of the standard simulation configuration, at the cost of significant database and networking challenges. Real proton-proton background events can be overlaid (at the detector digitization output stage) on a simulated hard-scatter process, to account for pileup background (from nearby bunch crossings), cavern background, and detector noise. A similar method is used to account for the large underlying event from heavy ion collisions, rather than directly simulating the full collision. Embedding replaces the muons found in Z→μμ decays in data with simulated taus at the same 4-momenta, thus preserving the underlying event and pileup from the original data event. In all these cases, care must be taken to exactly match detector conditions (beamspot, magnetic fields, alignments, dead sensors, etc.) between the real data event and the simulation. We will discuss the status of these overlay and embedding techniques within ATLAS software and computing.

Event generator tunes obtained from underlying event and multiparton scattering measurements.

PubMed

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Dev, N; Hildreth, M; Jessop, C; Karmgard, D J; Kellams, N; Lannon, K; Marinelli, N; Meng, F; Mueller, C; Musienko, Y; Planer, M; Reinsvold, A; Ruchti, R; Smith, G; Taroni, S; Valls, N; Wayne, M; Wolf, M; Woodard, A; Antonelli, L; Brinson, J; Bylsma, B; Durkin, L S; Flowers, S; Hart, A; Hill, C; Hughes, R; Ji, W; Ling, T Y; Liu, B; Luo, W; Puigh, D; Rodenburg, M; Winer, B L; Wulsin, H W; Driga, O; Elmer, P; Hardenbrook, J; Hebda, P; Koay, S A; Lujan, P; Marlow, D; Medvedeva, T; Mooney, M; Olsen, J; Palmer, C; Piroué, P; Saka, H; Stickland, D; Tully, C; Zuranski, A; Malik, S; Barnes, V E; Benedetti, D; Bortoletto, D; Gutay, L; Jha, M K; Jones, M; Jung, K; Miller, D H; Neumeister, N; Primavera, F; Radburn-Smith, B C; Shi, X; Shipsey, I; Silvers, D; Sun, J; Svyatkovskiy, A; Wang, F; Xie, W; Xu, L; Parashar, N; Stupak, J; Adair, A; Akgun, B; Chen, Z; Ecklund, K M; Geurts, F J M; Guilbaud, M; Li, W; Michlin, B; Northup, M; Padley, B P; Redjimi, R; Roberts, J; Rorie, J; Tu, Z; Zabel, J; Betchart, B; Bodek, A; de Barbaro, P; Demina, R; Eshaq, Y; Ferbel, T; Galanti, M; Galanti, M; Garcia-Bellido, A; Han, J; Harel, A; Hindrichs, O; Hindrichs, O; Khukhunaishvili, A; Petrillo, G; Tan, P; Verzetti, M; Arora, S; Barker, A; Chou, J P; Contreras-Campana, C; Contreras-Campana, E; Ferencek, D; Gershtein, Y; Gray, R; Halkiadakis, E; Hidas, D; Hughes, E; Kaplan, S; Kunnawalkam Elayavalli, R; Lath, A; Nash, K; Panwalkar, S; Park, M; Salur, S; Schnetzer, S; Sheffield, D; Somalwar, S; Stone, R; Thomas, S; Thomassen, P; Walker, M; Foerster, M; Riley, G; Rose, K; Spanier, S; York, A; Bouhali, O; Castaneda Hernandez, A; Celik, A; Dalchenko, M; De Mattia, M; Delgado, A; Dildick, S; Dildick, S; Eusebi, R; Gilmore, J; Huang, T; Kamon, T; Krutelyov, V; Krutelyov, V; Mueller, R; Osipenkov, I; Pakhotin, Y; Patel, R; Patel, R; Perloff, A; Rose, A; Safonov, A; Tatarinov, A; Ulmer, K A; Akchurin, N; Cowden, C; Damgov, J; Dragoiu, C; Dudero, P R; Faulkner, J; Kunori, S; Lamichhane, K; Lee, S W; Libeiro, T; Undleeb, S; Volobouev, I; Appelt, E; Delannoy, A G; Greene, S; Gurrola, A; Janjam, R; Johns, W; Maguire, C; Mao, Y; Melo, A; Ni, H; Sheldon, P; Snook, B; Tuo, S; Velkovska, J; Xu, Q; Arenton, M W; Cox, B; Francis, B; Goodell, J; Hirosky, R; Ledovskoy, A; Li, H; Lin, C; Neu, C; Sinthuprasith, T; Sun, X; Wang, Y; Wolfe, E; Wood, J; Xia, F; Clarke, C; Harr, R; Karchin, P E; Kottachchi Kankanamge Don, C; Lamichhane, P; Sturdy, J; Belknap, D A; Carlsmith, D; Cepeda, M; Dasu, S; Dodd, L; Duric, S; Gomber, B; Grothe, M; Hall-Wilton, R; Herndon, M; Hervé, A; Klabbers, P; Lanaro, A; Levine, A; Long, K; Loveless, R; Mohapatra, A; Ojalvo, I; Perry, T; Pierro, G A; Polese, G; Ruggles, T; Sarangi, T; Savin, A; Sharma, A; Smith, N; Smith, W H; Taylor, D; Woods, N

New sets of parameters ("tunes") for the underlying-event (UE) modelling of the pythia8, pythia6 and herwig++ Monte Carlo event generators are constructed using different parton distribution functions. Combined fits to CMS UE proton-proton ([Formula: see text]) data at [Formula: see text] and to UE proton-antiproton ([Formula: see text]) data from the CDF experiment at lower [Formula: see text], are used to study the UE models and constrain their parameters, providing thereby improved predictions for proton-proton collisions at 13[Formula: see text]. In addition, it is investigated whether the values of the parameters obtained from fits to UE observables are consistent with the values determined from fitting observables sensitive to double-parton scattering processes. Finally, comparisons are presented of the UE tunes to "minimum bias" (MB) events, multijet, and Drell-Yan ([Formula: see text] lepton-antilepton+jets) observables at 7 and 8[Formula: see text], as well as predictions for MB and UE observables at 13[Formula: see text].

Large Nankai Trough earthquake and tsunami found in lacustrine deposits through late Holocene-time along the western coast of Kii Peninsula, southwestern Japan

NASA Astrophysics Data System (ADS)

Okamura, M.; Matsuoka, H.; Tsuzuki, M.; Toraya, K.

2015-12-01

We continue paleo-seismic studies through Late Holocene-time in coastal marsh ponds along the Nankai Trough . These ponds which are co-seismic subsidence areas have continuous muddy sediment stratigraphy and sporadic tsunami induced coarse material. Well controlled age data has been collected from the core-sample that contains plant remains under anoxic sedimentary environment . Total 21 cores collected from two coastal ponds Ashihama-ike and Zasa-ike which locate behind beach-ridge along southeastern coast of Kii Peninsula under Tokai/Tonankai Earthquake assumption areas. Tsunami events are recognized after eighty AMS C-14 dating through recent (core top) to 7300 yBP interval. Among these interval, two remarkable events found in sediment, which are 2050yBP to 2300yBP (=2K event) and 1000yBP to 1100 yBP. 2k event consists thick sand, well rounded gravel in chaotic mud and wood fragment derived from forests surrounding lakes. Later event is correspond to the historical Ninna Nankai earthquake (AD887, 26 August under the old lunar calendar).　Rather small events are occurred in 3500yBP and 1100yBP. These events are found from both of two ponds which has two kilometers in distance each other. Cores bottom are composed of 7400yBP huge-tsunami event caused simultaneously by the Kikai-caldera eruption (over 170 cubic km ejecta) is just covered with the Kikai-Akahoya (K-Ah) tephra. The 2K and volcanic tsunami events have also found widely, not only Kii Peninsula but southern Shikoku (Tokushima Pref. and Kochi Pref.) and Kyushu through the Nankai Trough.

They all do it, will you? Event-related potential evidence of herding behavior in online peer-to-peer lending.

PubMed

Yu, Haihong; Dan, MengHan; Ma, Qingguo; Jin, Jia

2018-05-14

As herding is a typical characteristic of human behavior, many researchers have found the existence of herding behavior in online peer-to-peer lending through empirical surveys. However, the underlying neural basis of this phenomenon is still unclear. In the current study, we studied the neural activities of herding at decision-making stage and feedback stage using event-related potentials (ERPs). Our results showed that at decision-making stage, larger error related negativity (ERN) amplitude was induced under low-proportion conditions than that of high-proportion conditions. Meanwhile, during feedback stage, negative feedback elicited larger feedback related negativity (FRN) amplitude than that of positive feedback under low-proportion conditions, however, there was no significant FRN difference under high-proportion conditions. The current study suggests that herding behavior in online peer-to-peer lending is related to individual's risk perception and is possible to avoid negative emotions brought by failed investments. Copyright © 2018 Elsevier B.V. All rights reserved.

The interplay of stressful life events and coping skills on risk for suicidal behavior among youth students in contemporary China: a large scale cross-sectional study.

PubMed

Tang, Fang; Xue, Fuzhong; Qin, Ping

2015-07-31

Stressful life events are common among youth students and may induce psychological problems and even suicidal behaviors in those with poor coping skills. This study aims to assess the influence of stressful life events and coping skills on risk for suicidal behavior and to elucidate the underlying mechanism using a large sample of university students in China. 5972 students, randomly selected from 6 universities, completed the questionnaire survey. Logistic regression analysis was performed to estimate the effect of stressful life events and coping skills on risk for suicidal behavior. Bayesian network was further adopted to probe their probabilistic relationships. Of the 5972 students, 7.64% reported the presence of suicidal behavior (attempt or ideation) within the past one year period. Stressful life events such as strong conflicts with classmates and a failure in study exam constituted strong risk factors for suicidal behavior. The influence of coping skills varied according to the strategies adapted toward problems with a high score of approach coping skills significantly associated with a reduced risk of suicidal behavior. The Bayesian network indicated that the probability of suicidal behavior associated with specific life events was to a large extent conditional on coping skills. For instance, a stressful experience of having strong conflicts with classmates could result in a probability of suicidal behavior of 21.25% and 15.36% respectively, for female and male students with the score of approach coping skills under the average. Stressful life events and deficient coping skills are strong risk factors for suicidal behavior among youth students. The results underscore the importance of prevention efforts to improve coping skills towards stressful life events.

Deformation behaviors of three-dimensional graphene honeycombs under out-of-plane compression: Atomistic simulations and predictive modeling

NASA Astrophysics Data System (ADS)

Meng, Fanchao; Chen, Cheng; Hu, Dianyin; Song, Jun

2017-12-01

Combining atomistic simulations and continuum modeling, a comprehensive study of the out-of-plane compressive deformation behaviors of equilateral three-dimensional (3D) graphene honeycombs was performed. It was demonstrated that under out-of-plane compression, the honeycomb exhibits two critical deformation events, i.e., elastic mechanical instability (including elastic buckling and structural transformation) and inelastic structural collapse. The above events were shown to be strongly dependent on the honeycomb cell size and affected by the local atomic bonding at the cell junction. By treating the 3D graphene honeycomb as a continuum cellular solid, and accounting for the structural heterogeneity and constraint at the junction, a set of analytical models were developed to accurately predict the threshold stresses corresponding to the onset of those deformation events. The present study elucidates key structure-property relationships of 3D graphene honeycombs under out-of-plane compression, and provides a comprehensive theoretical framework to predictively analyze their deformation responses, and more generally, offers critical new knowledge for the rational bottom-up design of 3D networks of two-dimensional nanomaterials.

Research on Visual Analysis Methods of Terrorism Events

NASA Astrophysics Data System (ADS)

Guo, Wenyue; Liu, Haiyan; Yu, Anzhu; Li, Jing

2016-06-01

Under the situation that terrorism events occur more and more frequency throughout the world, improving the response capability of social security incidents has become an important aspect to test governments govern ability. Visual analysis has become an important method of event analysing for its advantage of intuitive and effective. To analyse events' spatio-temporal distribution characteristics, correlations among event items and the development trend, terrorism event's spatio-temporal characteristics are discussed. Suitable event data table structure based on "5W" theory is designed. Then, six types of visual analysis are purposed, and how to use thematic map and statistical charts to realize visual analysis on terrorism events is studied. Finally, experiments have been carried out by using the data provided by Global Terrorism Database, and the results of experiments proves the availability of the methods.

Event-based cluster synchronization of coupled genetic regulatory networks

NASA Astrophysics Data System (ADS)

Yue, Dandan; Guan, Zhi-Hong; Li, Tao; Liao, Rui-Quan; Liu, Feng; Lai, Qiang

2017-09-01

In this paper, the cluster synchronization of coupled genetic regulatory networks with a directed topology is studied by using the event-based strategy and pinning control. An event-triggered condition with a threshold consisting of the neighbors' discrete states at their own event time instants and a state-independent exponential decay function is proposed. The intra-cluster states information and extra-cluster states information are involved in the threshold in different ways. By using the Lyapunov function approach and the theories of matrices and inequalities, we establish the cluster synchronization criterion. It is shown that both the avoidance of continuous transmission of information and the exclusion of the Zeno behavior are ensured under the presented triggering condition. Explicit conditions on the parameters in the threshold are obtained for synchronization. The stability criterion of a single GRN is also given under the reduced triggering condition. Numerical examples are provided to validate the theoretical results.

Correlation of residual strength with acoustic emission from impact-damaged composite structures under constant biaxial load

NASA Astrophysics Data System (ADS)

Hamstad, M. A.; Whittaker, J. W.; Brosey, W. D.

1992-01-01

Small, filament-wound, Kevlar/epoxy, biaxial test specimens were subjected to various levels of impact damage. The specimens were pressurized in a proof test cycle to 58 percent of their nominal, undamaged strength and then pressurized to failure. Acoustic emission data were gathered by multiple sensors during a 10 minute hold at peak proof pressure. Post-test filtering of the data was performed to study composite behavior in the damaged region and other areas. The rate and total amount of AE produced depends on the duration of the static load and degree of damage. The concept of the event rate moment is introduced as a method of quantifying a structure's total AE behavior when under static load. Average event rate, total long duration events, and event rate moments provided various degrees of correlation between AE and residual strength.

Component processes underlying future thinking.

PubMed

D'Argembeau, Arnaud; Ortoleva, Claudia; Jumentier, Sabrina; Van der Linden, Martial

2010-09-01

This study sought to investigate the component processes underlying the ability to imagine future events, using an individual-differences approach. Participants completed several tasks assessing different aspects of future thinking (i.e., fluency, specificity, amount of episodic details, phenomenology) and were also assessed with tasks and questionnaires measuring various component processes that have been hypothesized to support future thinking (i.e., executive processes, visual-spatial processing, relational memory processing, self-consciousness, and time perspective). The main results showed that executive processes were correlated with various measures of future thinking, whereas visual-spatial processing abilities and time perspective were specifically related to the number of sensory descriptions reported when specific future events were imagined. Furthermore, individual differences in self-consciousness predicted the subjective feeling of experiencing the imagined future events. These results suggest that future thinking involves a collection of processes that are related to different facets of future-event representation.

Well-being and Anticipation for Future Positive Events: Evidences from an fMRI Study.

PubMed

Luo, Yangmei; Chen, Xuhai; Qi, Senqing; You, Xuqun; Huang, Xiting

2017-01-01

Anticipation for future confers great benefits to human well-being and mental health. However, previous work focus on how people's well-being correlate with brain activities during perception of emotional stimuli, rather than anticipation for the future events. Here, the current study investigated how well-being relates to neural circuitry underlying the anticipating process of future desired events. Using event-related functional magnetic resonance imaging, 40 participants were scanned while they were performing an emotion anticipation task, in which they were instructed to anticipate the positive or neutral events. The results showed that bilateral medial prefrontal cortex (MPFC) were activated during anticipation for positive events relative to neutral events, and the enhanced brain activation in MPFC was associated with higher level of well-being. The findings suggest a neural mechanism by which the anticipation process to future desired events correlates to human well-being, which provide a future-oriented view on the neural sources of well-being.

Well-being and Anticipation for Future Positive Events: Evidences from an fMRI Study

PubMed Central

Luo, Yangmei; Chen, Xuhai; Qi, Senqing; You, Xuqun; Huang, Xiting

2018-01-01

Anticipation for future confers great benefits to human well-being and mental health. However, previous work focus on how people’s well-being correlate with brain activities during perception of emotional stimuli, rather than anticipation for the future events. Here, the current study investigated how well-being relates to neural circuitry underlying the anticipating process of future desired events. Using event-related functional magnetic resonance imaging, 40 participants were scanned while they were performing an emotion anticipation task, in which they were instructed to anticipate the positive or neutral events. The results showed that bilateral medial prefrontal cortex (MPFC) were activated during anticipation for positive events relative to neutral events, and the enhanced brain activation in MPFC was associated with higher level of well-being. The findings suggest a neural mechanism by which the anticipation process to future desired events correlates to human well-being, which provide a future-oriented view on the neural sources of well-being. PMID:29375415

Freezing degrees of freedom under stress: kinematic evidence of constrained movement strategies.

PubMed

Higuchi, Takahiro; Imanaka, Kuniyasu; Hatayama, Toshiteru

2002-12-01

The present study investigated the effect of psychological stress imposed on movement kinematics in a computer-simulated batting task involving a backward and forward swing of the forearm. The psychological stress was imposed by a mild electric stimulus following poor performance. Fourteen participants hit a moving ball with a horizontal lever and aimed at a distant target with as much accuracy as possible. The kinematic characteristics appearing under stress were delay of movement initiation, small amplitude of movement and low variability of spatial kinematic events between trials. These features were also found in previous studies in which the experimental task required high accuracy. The characteristic kinematics evident in the present study suggested that the movement strategies adopted by the stressed participants were similar to those that appear under high accuracy demand. Moreover, a correlation analysis between the onset times of kinematic events revealed that temporally consistent movements were reproduced under stress. Taken together, the present findings demonstrated that, under psychological stress, movement strategies tend to shift toward the production of more constrained trajectories, as is seen under conditions of high accuracy demand, even though the difficulty of the task itself does not change. Copyright 2002 Elsevier Science B.V.

Geoenvironmental Diabetology

PubMed Central

Cook, Curtiss B; Wellik, Kay E; Fowke, Margaret

2011-01-01

Many reports have documented the negative health consequences that environmental stressors can have on patients with diabetes. Studies examining the interaction between the environment and a patient with diabetes can be unified under a single discipline termed “geoenvironmental diabetology.” Geoenvironmental diabetology is defined more specifically as the study of how geophysical phenomena impact a patient with diabetes, to include effects on metabolic control, ancillary equipment (e.g., glucometers and insulin pumps), medications, supplies, access to care, and influences on the adaptive strategies employed by patients to care for their diabetes under extreme circumstances. Geological events such as natural disasters (e.g., earthquakes) or extreme weather (e.g., heat waves) are examples of stressors that can affect patients with diabetes and that can be included under the heading of geoenvironmental diabetology. As proposed here, geoenvironmental diabetology refers to how events in the physical world affect those with diagnosed diabetes, rather than how environmental factors might trigger development of disease. As the global prevalence of diabetes continues to increase, including in parts of the world that are especially vulnerable to disasters and climate change, further discussion is warranted on how to best prepare for management of diabetes under conditions of extreme geological and weather events and a changing climate. An overview is presented of various studies that have detailed how geoenvironmental phenomena can adversely affect patients with diabetes and concludes with a discussion of requirements for developing strategies for geoenvironmental diabetes management. PMID:21880222

Duration of Exposure and the Dose-Response Model of PTSD

ERIC Educational Resources Information Center

Kaysen, Debra; Rosen, Gerald; Bowman, Marilyn; Resick, Patricia A.

2010-01-01

A dose-response model underlies posttraumatic stress disorder (PTSD) and posits a relationship between event magnitude and clinical outcome. The present study examines whether one index of event magnitude--duration of exposure--contributes to risk of PTSD among female victims of sexual assault. Findings support a small but significant contribution…

The Power of Nature. World's Largest Math Event 5.

ERIC Educational Resources Information Center

National Council of Teachers of Mathematics, Inc., Reston, VA.

The theme of the fifth annual World's Largest Math Event (WLME 5) is "The Power of Nature." This theme encourages students to explore natural forces that affect humankind, including phenomena such as hurricanes, earthquakes, and snowstorms, and the mathematics that underlies their study. The 15 activities for WLMES have been grouped into five…

Proactive Control Processes in Event-Based Prospective Memory: Evidence from Intraindividual Variability and Ex-Gaussian Analyses

ERIC Educational Resources Information Center

Ball, B. Hunter; Brewer, Gene A.

2018-01-01

The present study implemented an individual differences approach in conjunction with response time (RT) variability and distribution modeling techniques to better characterize the cognitive control dynamics underlying ongoing task cost (i.e., slowing) and cue detection in event-based prospective memory (PM). Three experiments assessed the relation…

Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines

PubMed Central

Buetfering, Christina; Groblewski, Peter A.; Manavi, Sahar; Miles, Jesse; White, Casey; Griffin, Fiona; Roll, Kate; Cross, Sissy; Nguyen, Thuyanh V.; Larsen, Rachael; Daigle, Tanya; Thompson, Carol L.; Olsen, Shawn; Hausser, Michael

2017-01-01

Abstract Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors. These epileptiform events have been observed particularly, but not exclusively, in mice with Emx1-Cre and Ai93 transgenes, of either sex, across multiple laboratories. The events occur at >0.1 Hz, are very large in amplitude (>1.0 mV local field potentials, >10% df/f widefield imaging signals), and typically cover large regions of cortex. Many properties of neuronal responses and behavior seem normal despite these events, although rare subjects exhibit overt generalized seizures. The underlying mechanisms of this phenomenon remain unclear, but we speculate about possible causes on the basis of diverse observations. We encourage researchers to be aware of these activity patterns while interpreting neuronal recordings from affected mouse lines and when considering which lines to study. PMID:28932809

Human contribution to the United States extreme heatwaves in the coming decades

NASA Astrophysics Data System (ADS)

Russo, E.; Marchese, A. F.; Immè, G.; Russo, S.

2015-12-01

In the past decades many intense and long heatwaves have hit large areas across the United States producing notable impacts on human mortality,regional economies, and natural ecosystems.Evidence indicates that anthropogenic climate change will alter the magnitude and frequency of these events. Here, by means of the Heat Wave Magnitude Index daily (HWMId) applied to daily maximum temperature from the United States reanalysis dataset (NLDAS-2), we grade the heat waves occurred in the U.S. since 1980, demonstrating that the two worst events within the studied period occurred in the summer of 1980 and 2011. Moreover, by referring to these two events as extremes, we show that model predictions from the North American COordinated Regional climate Downscaling EXperiment (CORDEX) under different IPCC AR5 scenarios, suggest an increased risk of occurrence of extreme heat waves in the near future (2021-2050). In particular, under the most severe scenario, events of the same severity, as the 1980 and 2011 U.S. heat waves, will become more likely in the studied region.

Analyzing semi-competing risks data with missing cause of informative terminal event.

PubMed

Zhou, Renke; Zhu, Hong; Bondy, Melissa; Ning, Jing

2017-02-28

Cancer studies frequently yield multiple event times that correspond to landmarks in disease progression, including non-terminal events (i.e., cancer recurrence) and an informative terminal event (i.e., cancer-related death). Hence, we often observe semi-competing risks data. Work on such data has focused on scenarios in which the cause of the terminal event is known. However, in some circumstances, the information on cause for patients who experience the terminal event is missing; consequently, we are not able to differentiate an informative terminal event from a non-informative terminal event. In this article, we propose a method to handle missing data regarding the cause of an informative terminal event when analyzing the semi-competing risks data. We first consider the nonparametric estimation of the survival function for the terminal event time given missing cause-of-failure data via the expectation-maximization algorithm. We then develop an estimation method for semi-competing risks data with missing cause of the terminal event, under a pre-specified semiparametric copula model. We conduct simulation studies to investigate the performance of the proposed method. We illustrate our methodology using data from a study of early-stage breast cancer. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

The time to remember: Temporal compression and duration judgements in memory for real-life events.

PubMed

Jeunehomme, Olivier; D'Argembeau, Arnaud

2018-05-01

Recent studies suggest that the continuous flow of information that constitutes daily life events is temporally compressed in episodic memory, yet the characteristics and determinants of this compression mechanism remain unclear. This study examined this question using an experimental paradigm incorporating wearable camera technology. Participants experienced a series of real-life events and were later asked to mentally replay various event sequences that were cued by pictures taken during the original events. Estimates of temporal compression (the ratio of the time needed to mentally re-experience an event to the actual event duration) showed that events were replayed, on average, about eight times faster than the original experiences. This compression mechanism seemed to operate by representing events as a succession of moments or slices of prior experience separated by temporal discontinuities. Importantly, however, rates of temporal compression were not constant and were lower for events involving goal-directed actions. The results also showed that the perceived duration of events increased with the density of recalled moments of prior experience. Taken together, these data extend our understanding of the mechanisms underlying the temporal compression and perceived duration of real-life events in episodic memory.

Quantifying black carbon deposition over the Greenland ice sheet from forest fires in Canada: BC DEPOSITION FROM FOREST FIRES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, J. L.; Polashenski, C. M.; Soja, A. J.

We identify an important Black Carbon (BC) aerosol deposition event that was observed in snow stratigraphy and dated to between 27 July 2013 – 2 August 2013. This event comprises a significant portion (~60%) of total deposition over a 10 month period (July 2013 – April 2014). Here we link this event to forest fires burning in Canada during summer 2013 using modeling and remote sensing tools. Aerosols were detected by both the CALIOP and MODIS instruments during transport between Canada and Greenland, confirming that this event involved emissions from forest fires in Canada. We use high-resolution regional chemical transportmore » mod-eling (WRF-Chem) combined with high-resolution fire emissions (FINNv1.5) to study aerosol emissions, transport, and deposition during this event. The model accurately captures the timing of the BC deposition event and shows that the major contribution to deposition during this event is emissions originating from fires in Canada. However, the model under-predicts aerosol deposition compared to measurements at all sites by a factor of 2–100. Under-prediction of modeled BC deposition originates from uncertainties in fire emissions combined with uncertainties in aerosol scavenging by clouds. This study suggests that it is possible to describe the transport of an exceptional smoke event on regional and continental scales. Improvements in model descriptions of precipitation scavenging and emissions from wildfires are needed to correctly predict deposition, which is critical for determining the climate impacts of aerosols that originate from fires.« less

Injury case-control studies using "other injuries" as controls.

PubMed

Marshall, Stephen W

2008-03-01

Studies of event-related (or "event-phase") interventions (such as ski helmets) can address injury at a specific body site (such as the head) by using as controls a group of people who experienced the same event (fall) and suffered injuries at other body sites (other than the head). The research question addressed by this type of study is the effect of an exposure or intervention (helmet) during the event phase (fall) of the causal chain. However, this is a valid case-control design only if the controls (skiers with other injuries) provide a reasonable proxy for the prevalence of exposure (helmet-wearing) in the underlying event-phase source population (skiers who fell). This assumption needs to be carefully assessed. Factors associated with both helmet-wearing and injury given a fall (eg, previous injury history, skiing inexperience, or risk-taking behavior) have considerable potential to create bias.

Stressful Life Events as a Predictor for Nonsuicidal Self-Injury in Southern Chinese Adolescence

PubMed Central

Tang, Jie; Yang, Wei; Ahmed, Niman Isse; Ma, Ying; Liu, Hui-Yan; Wang, Jia-Ji; Wang, Pei-Xi; Du, Yu-Kai; Yu, Yi-Zhen

2016-01-01

Abstract Stressful life events have been implicated in the etiology of kinds of psychopathology related to nonsuicidal self-injury (NSSI); however, few studies have examined the association between NSSI and stressful life events directly in Chinese school adolescents. In this study, we aim to estimate the prevalence rate of NSSI and examine its association with stressful life events in Southern Chinese adolescents. A total sample of 4405 students with age ranged from 10 to 22 years was randomly selected from 12 schools in 3 cities of Guangdong Province, China. NSSI, stressful life events, self-esteem, emotional management, and coping methods were measured by structured questionnaires. Multinomial logistic regression was used to examine the association of NSSI with stressful life events. Results showed the 1 year self-reported NSSI was 29.2%, with 22.6% engaged in “minor” NSSI (including hitting self, pulling hair, biting self, inserting objects under nails or skin, picking at a wound) and 6.6% in “moderate/sever” NSSI (including cutting/carving, burning, self-tattooing, scraping, and erasing skin). Self-hitting (15.9%), pulling hair out (10.9%), and self-inserting objects under nails or skin picking areas to dram blood (18.3%) were the most frequent types of NSSI among adolescents. Results also showed that “Minor NSSI” was associated with stressful life events on interpersonal, loss and health adaption, and “moderate/severe NSSI” was associated with life events on interpersonal, health adaption in Southern Chinese adolescents, even after adjusted for sex, age, residence, self-esteem, coping style, and emotional management. Results further suggested stressful life events were significantly associated with less risk of NSSI in those who had good emotional management ability. PMID:26945351

Cyclones and extreme windstorm events over Europe under climate change: Global and regional climate model diagnostics

NASA Astrophysics Data System (ADS)

Leckebusch, G. C.; Ulbrich, U.

2003-04-01

More than any changes of the climate system mean state conditions, the development of extreme events may influence social, economic and legal aspects of our society. This linkage results from the impact of extreme climate events (natural hazards) on environmental systems which again are directly linked to human activities. Prominent examples from the recent past are the record breaking rainfall amounts of August 2002 in central Europe which produced widespread floodings or the wind storm Lothar of December 1999. Within the MICE (Modelling the Impact of Climate Extremes) project framework an assessment of the impact of changes in extremes will be done. The investigation is carried out for several different impact categories as agriculture, energy use and property damage. Focus is laid on the diagnostics of GCM and RCM simulations under different climate change scenarios. In this study we concentrate on extreme windstorms and their relationship to cyclone activity in the global HADCM3 as well as in the regional HADRM3 model under two climate change scenarios (SRESA2a, B2a). In order to identify cyclones we used an objective algorithm from Murry and Simmonds which was widely tested under several different conditions. A slight increase in the occurrence of systems is identified above northern parts of central Europe for both scenarios. For more severe systems (core pressure < 990 hPa) we find an increase for western Europe. Strong wind events can be defined via different percentile values of the windspeed (e.g. above the 95 percentile). By this means the relationship between strong wind events and cyclones is also investigated. For several regions (e.g. Germany, France, Spain) a shift to more deep cyclones connected with an increasing number of strong wind events is found.

City-scale accessibility of emergency responders operating during flood events

NASA Astrophysics Data System (ADS)

Green, Daniel; Yu, Dapeng; Pattison, Ian; Wilby, Robert; Bosher, Lee; Patel, Ramila; Thompson, Philip; Trowell, Keith; Draycon, Julia; Halse, Martin; Yang, Lili; Ryley, Tim

2017-01-01

Emergency responders often have to operate and respond to emergency situations during dynamic weather conditions, including floods. This paper demonstrates a novel method using existing tools and datasets to evaluate emergency responder accessibility during flood events within the city of Leicester, UK. Accessibility was quantified using the 8 and 10 min legislative targets for emergency provision for the ambulance and fire and rescue services respectively under "normal" no-flood conditions, as well as flood scenarios of various magnitudes (1 in 20-year, 1 in 100-year and 1 in 1000-year recurrence intervals), with both surface water and fluvial flood conditions considered. Flood restrictions were processed based on previous hydrodynamic inundation modelling undertaken and inputted into a Network Analysis framework as restrictions for surface water and fluvial flood events. Surface water flooding was shown to cause more disruption to emergency responders operating within the city due to its widespread and spatially distributed footprint when compared to fluvial flood events of comparable magnitude. Fire and rescue 10 min accessibility was shown to decrease from 100, 66.5, 39.8 and 26.2 % under the no-flood, 1 in 20-year, 1 in 100-year and 1 in 1000-year surface water flood scenarios respectively. Furthermore, total inaccessibility was shown to increase with flood magnitude from 6.0 % under the 1 in 20-year scenario to 31.0 % under the 1 in 100-year flood scenario. Additionally, the evolution of emergency service accessibility throughout a surface water flood event is outlined, demonstrating the rapid impact on emergency service accessibility within the first 15 min of the surface water flood event, with a reduction in service coverage and overlap being observed for the ambulance service during a 1 in 100-year flood event. The study provides evidence to guide strategic planning for decision makers prior to and during emergency response to flood events at the city scale. It also provides a readily transferable method for exploring the impacts of natural hazards or disruptions in other cities or regions based on historic, scenario-based events or real-time forecasting, if such data are available.

Percolation Features on Climate Network under Attacks of El Niño Events

NASA Astrophysics Data System (ADS)

Lu, Z.

2015-12-01

Percolation theory under different attacks is one of the main research areas in complex networks but never be applied to investigate climate network. In this study, for the first time we construct a climate network of surface air temperature field to analyze its percolation features. Here, we regard El Niño event as a kind of naturally attacks generated from Pacific Ocean to attack its upper climate network. We find that El Niño event leads an abrupt percolation phase transition to the climate network which makes it splitting and unstable suddenly. Comparing the results of the climate network under three different forms of attacks, including most connected attack (MA), localized attack (LA) and random attack (RA) respectively, it is found that both MA and LA lead first-order transition and RA leads second-order transition to the climate network. Furthermore, we find that most real attacks consist of all these three forms of attacks. With El Niño event emerging, the ratios of LA and MA increase and dominate the style of attack while RA decreasing. It means the percolation phase transition due to El Niño events is close to first-order transition mostly affected by LA and MA. Our research may help us further understand two questions from perspective of percolation on network: (1) Why not all warming in Pacific Ocean but El Niño events could affect the climate. (2) Why the climate affected by El Niño events changes abruptly.

Regression analysis of mixed recurrent-event and panel-count data

PubMed Central

Zhu, Liang; Tong, Xinwei; Sun, Jianguo; Chen, Manhua; Srivastava, Deo Kumar; Leisenring, Wendy; Robison, Leslie L.

2014-01-01

In event history studies concerning recurrent events, two types of data have been extensively discussed. One is recurrent-event data (Cook and Lawless, 2007. The Analysis of Recurrent Event Data. New York: Springer), and the other is panel-count data (Zhao and others, 2010. Nonparametric inference based on panel-count data. Test 20, 1–42). In the former case, all study subjects are monitored continuously; thus, complete information is available for the underlying recurrent-event processes of interest. In the latter case, study subjects are monitored periodically; thus, only incomplete information is available for the processes of interest. In reality, however, a third type of data could occur in which some study subjects are monitored continuously, but others are monitored periodically. When this occurs, we have mixed recurrent-event and panel-count data. This paper discusses regression analysis of such mixed data and presents two estimation procedures for the problem. One is a maximum likelihood estimation procedure, and the other is an estimating equation procedure. The asymptotic properties of both resulting estimators of regression parameters are established. Also, the methods are applied to a set of mixed recurrent-event and panel-count data that arose from a Childhood Cancer Survivor Study and motivated this investigation. PMID:24648408

The organization of prospective thinking: evidence of event clusters in freely generated future thoughts.

PubMed

Demblon, Julie; D'Argembeau, Arnaud

2014-02-01

Recent research suggests that many imagined future events are not represented in isolation, but instead are embedded in broader event sequences-referred to as event clusters. It remains unclear, however, whether the production of event clusters reflects the underlying organizational structure of prospective thinking or whether it is an artifact of the event-cuing task in which participants are explicitly required to provide chains of associated future events. To address this issue, the present study examined whether the occurrence of event clusters in prospective thought is apparent when people are left to think freely about events that might happen in their personal future. The results showed that the succession of events participants spontaneously produced when envisioning their future frequently included event clusters. This finding provides more compelling evidence that prospective thinking involves higher-order autobiographical knowledge structures that organize imagined events in coherent themes and sequences. Copyright © 2014 Elsevier Inc. All rights reserved.

Measurement of underlying event characteristics using charged particles in pp collisions at s=900GeV and 7 TeV with the ATLAS detector

NASA Astrophysics Data System (ADS)

Aad, G.; Abbott, B.; Abdallah, J.; Abdelalim, A. A.; Abdesselam, A.; Abdinov, O.; Abi, B.; Abolins, M.; Abramowicz, H.; Abreu, H.; Acerbi, E.; Acharya, B. S.; Ackers, M.; Adams, D. L.; Addy, T. N.; Adelman, J.; Aderholz, M.; Adomeit, S.; Adragna, P.; Adye, T.; Aefsky, S.; Aguilar-Saavedra, J. A.; Aharrouche, M.; Ahlen, S. P.; Ahles, F.; Ahmad, A.; Ahmed, H.; Ahsan, M.; Aielli, G.; Akdogan, T.; Åkesson, T. P. A.; Akimoto, G.; Akimov, A. V.; Alam, M. S.; Alam, M. A.; Albrand, S.; Aleksa, M.; Aleksandrov, I. N.; Aleppo, M.; Alessandria, F.; Alexa, C.; Alexander, G.; Alexandre, G.; Alexopoulos, T.; Alhroob, M.; Aliev, M.; Alimonti, G.; Alison, J.; Aliyev, M.; Allport, P. P.; Allwood-Spiers, S. E.; Almond, J.; Aloisio, A.; Alon, R.; Alonso, A.; Alonso, J.; Alviggi, M. G.; Amako, K.; Amaral, P.; Amelung, C.; Ammosov, V. V.; Amorim, A.; Amorós, G.; Amram, N.; Anastopoulos, C.; Andeen, T.; Anders, C. F.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Andrieux, M.-L.; Anduaga, X. S.; Angerami, A.; Anghinolfi, F.; Anjos, N.; Annovi, A.; Antonaki, A.; Antonelli, M.; Antonelli, S.; Antos, J.; Antunovic, B.; Anulli, F.; Aoun, S.; Apolle, R.; Arabidze, G.; Aracena, I.; Arai, Y.; Arce, A. T. H.; Archambault, J. P.; Arfaoui, S.; Arguin, J.-F.; Argyropoulos, T.; Arik, E.; Arik, M.; Armbruster, A. J.; Arms, K. E.; Armstrong, S. R.; Arnaez, O.; Arnault, C.; Artamonov, A.; Arutinov, D.; Asai, S.; Asfandiyarov, R.; Ask, S.; Åsman, B.; Asquith, L.; Assamagan, K.; Astbury, A.; Astvatsatourov, A.; Atoian, G.; Aubert, B.; Auerbach, B.; Auge, E.; Augsten, K.; Aurousseau, M.; Austin, N.; Avramidou, R.; Axen, D.; Ay, C.; Azuelos, G.; Azuma, Y.; Baak, M. A.; Baccaglioni, G.; Bacci, C.; Bach, A. M.; Bachacou, H.; Bachas, K.; Bachy, G.; Backes, M.; Badescu, E.; Bagnaia, P.; Bai, Y.; Bailey, D. C.; Bain, T.; Baines, J. T.; Baker, O. K.; Baker, S.; Baltasar Dos Santos Pedrosa, F.; Banas, E.; Banerjee, P.; Banerjee, Sw.; Banfi, D.; Bangert, A.; Bansal, V.; Bansil, H. S.; Barak, L.; Baranov, S. P.; Barashkou, A.; Barbaro Galtieri, A.; Barber, T.; Barberio, E. L.; Barberis, D.; Barbero, M.; Bardin, D. Y.; Barillari, T.; Barisonzi, M.; Barklow, T.; Barlow, N.; Barnett, B. M.; Barnett, R. M.; Baroncelli, A.; Barr, A. J.; Barreiro, F.; Barreiro Guimarães da Costa, J.; Barrillon, P.; Bartoldus, R.; Barton, A. E.; Bartsch, D.; Bates, R. L.; Batkova, L.; Batley, J. R.; Battaglia, A.; Battistin, M.; Battistoni, G.; Bauer, F.; Bawa, H. S.; Beare, B.; Beau, T.; Beauchemin, P. H.; Beccherle, R.; Bechtle, P.; Beck, H. P.; Beckingham, M.; Becks, K. H.; Beddall, A. J.; Beddall, A.; Bednyakov, V. A.; Bee, C.; Begel, M.; Behar Harpaz, S.; Behera, P. K.; Beimforde, M.; Belanger-Champagne, C.; Belhorma, B.; Bell, P. J.; Bell, W. H.; Bella, G.; Bellagamba, L.; Bellina, F.; Bellomo, G.; Bellomo, M.; Belloni, A.; Belotskiy, K.; Beltramello, O.; Ben Ami, S.; Benary, O.; Benchekroun, D.; Benchouk, C.; Bendel, M.; Benedict, B. H.; Benekos, N.; Benhammou, Y.; Benjamin, D. P.; Benoit, M.; Bensinger, J. R.; Benslama, K.; Bentvelsen, S.; Berge, D.; Bergeaas Kuutmann, E.; Berger, N.; Berghaus, F.; Berglund, E.; Beringer, J.; Bernardet, K.; Bernat, P.; Bernhard, R.; Bernius, C.; Berry, T.; Bertin, A.; Bertinelli, F.; Bertolucci, F.; Besana, M. I.; Besson, N.; Bethke, S.; Bhimji, W.; Bianchi, R. M.; Bianco, M.; Biebel, O.; Biesiada, J.; Biglietti, M.; Bilokon, H.; Bindi, M.; Bingul, A.; Bini, C.; Biscarat, C.; Bischof, R.; Bitenc, U.; Black, K. M.; Blair, R. E.; Blanchard, J.-B.; Blanchot, G.; Blocker, C.; Blocki, J.; Blondel, A.; Blum, W.; Blumenschein, U.; Boaretto, C.; Bobbink, G. J.; Bobrovnikov, V. B.; Bocci, A.; Bock, R.; Boddy, C. R.; Boehler, M.; Boek, J.; Boelaert, N.; Böser, S.; Bogaerts, J. A.; Bogdanchikov, A.; Bogouch, A.; Bohm, C.; Boisvert, V.; Bold, T.; Boldea, V.; Boonekamp, M.; Boorman, G.; Booth, C. N.; Booth, P.; Booth, J. R. A.; Bordoni, S.; Borer, C.; Borisov, A.; Borissov, G.; Borjanovic, I.; Borroni, S.; Bos, K.; Boscherini, D.; Bosman, M.; Boterenbrood, H.; Botterill, D.; Bouchami, J.; Boudreau, J.; Bouhova-Thacker, E. V.; Boulahouache, C.; Bourdarios, C.; Bousson, N.; Boveia, A.; Boyd, J.; Boyko, I. R.; Bozhko, N. I.; Bozovic-Jelisavcic, I.; Braccini, S.; Bracinik, J.; Braem, A.; Brambilla, E.; Branchini, P.; Brandenburg, G. W.; Brandt, A.; Brandt, G.; Brandt, O.; Bratzler, U.; Brau, B.; Brau, J. E.; Braun, H. M.; Brelier, B.; Bremer, J.; Brenner, R.; Bressler, S.; Breton, D.; Brett, N. D.; Bright-Thomas, P. G.; Britton, D.; Brochu, F. M.; Brock, I.; Brock, R.; Brodbeck, T. J.; Brodet, E.; Broggi, F.; Bromberg, C.; Brooijmans, G.; Brooks, W. K.; Brown, G.; Brubaker, E.; Bruckman de Renstrom, P. A.; Bruncko, D.; Bruneliere, R.; Brunet, S.; Bruni, A.; Bruni, G.; Bruschi, M.; Buanes, T.; Bucci, F.; Buchanan, J.; Buchanan, N. J.; Buchholz, P.; Buckingham, R. M.; Buckley, A. G.; Buda, S. I.; Budagov, I. A.; Budick, B.; Büscher, V.; Bugge, L.; Buira-Clark, D.; Buis, E. J.; Bulekov, O.; Bunse, M.; Buran, T.; Burckhart, H.; Burdin, S.; Burgess, T.; Burke, S.; Busato, E.; Bussey, P.; Buszello, C. P.; Butin, F.; Butler, B.; Butler, J. M.; Buttar, C. M.; Butterworth, J. M.; Buttinger, W.; Byatt, T.; Cabrera Urbán, S.; Caccia, M.; Caforio, D.; Cakir, O.; Calafiura, P.; Calderini, G.; Calfayan, P.; Calkins, R.; Caloba, L. P.; Caloi, R.; Calvet, D.; Calvet, S.; Camard, A.; Camarri, P.; Cambiaghi, M.; Cameron, D.; Cammin, J.; Campana, S.; Campanelli, M.; Canale, V.; Canelli, F.; Canepa, A.; Cantero, J.; Capasso, L.; Capeans Garrido, M. D. M.; Caprini, I.; Caprini, M.; Caprio, M.; Capriotti, D.; Capua, M.; Caputo, R.; Caramarcu, C.; Cardarelli, R.; Carli, T.; Carlino, G.; Carminati, L.; Caron, B.; Caron, S.; Carpentieri, C.; Carrillo Montoya, G. D.; Carron Montero, S.; Carter, A. A.; Carter, J. R.; Carvalho, J.; Casadei, D.; Casado, M. P.; Cascella, M.; Caso, C.; Castaneda Hernandez, A. M.; Castaneda-Miranda, E.; Castillo Gimenez, V.; Castro, N. F.; Cataldi, G.; Cataneo, F.; Catinaccio, A.; Catmore, J. R.; Cattai, A.; Cattani, G.; Caughron, S.; Cavallari, A.; Cavalleri, P.; Cavalli, D.; Cavalli-Sforza, M.; Cavasinni, V.; Cazzato, A.; Ceradini, F.; Cerna, C.; Cerqueira, A. S.; Cerri, A.; Cerrito, L.; Cerutti, F.; Cervetto, M.; Cetin, S. A.; Cevenini, F.; Chafaq, A.; Chakraborty, D.; Chan, K.; Chapleau, B.; Chapman, J. D.; Chapman, J. W.; Chareyre, E.; Charlton, D. G.; Chavda, V.; Cheatham, S.; Chekanov, S.; Chekulaev, S. V.; Chelkov, G. A.; Chen, H.; Chen, L.; Chen, S.; Chen, T.; Chen, X.; Cheng, S.; Cheplakov, A.; Chepurnov, V. F.; Cherkaoui El Moursli, R.; Chernyatin, V.; Cheu, E.; Cheung, S. L.; Chevalier, L.; Chevallier, F.; Chiefari, G.; Chikovani, L.; Childers, J. T.; Chilingarov, A.; Chiodini, G.; Chizhov, M. V.; Choudalakis, G.; Chouridou, S.; Christidi, I. A.; Christov, A.; Chromek-Burckhart, D.; Chu, M. L.; Chudoba, J.; Ciapetti, G.; Ciftci, A. K.; Ciftci, R.; Cinca, D.; Cindro, V.; Ciobotaru, M. D.; Ciocca, C.; Ciocio, A.; Cirilli, M.; Clark, A.; Clark, P. J.; Cleland, W.; Clemens, J. C.; Clement, B.; Clement, C.; Clifft, R. W.; Coadou, Y.; Cobal, M.; Coccaro, A.; Cochran, J.; Coe, P.; Cogan, J. G.; Coggeshall, J.; Cogneras, E.; Cojocaru, C. D.; Colas, J.; Colijn, A. P.; Collard, C.; Collins, N. J.; Collins-Tooth, C.; Collot, J.; Colon, G.; Coluccia, R.; Comune, G.; Conde Muiño, P.; Coniavitis, E.; Conidi, M. C.; Consonni, M.; Constantinescu, S.; Conta, C.; Conventi, F.; Cook, J.; Cooke, M.; Cooper, B. D.; Cooper-Sarkar, A. M.; Cooper-Smith, N. J.; Copic, K.; Cornelissen, T.; Corradi, M.; Correard, S.; Corriveau, F.; Cortes-Gonzalez, A.; Cortiana, G.; Costa, G.; Costa, M. J.; Costanzo, D.; Costin, T.; Côté, D.; Coura Torres, R.; Courneyea, L.; Cowan, G.; Cowden, C.; Cox, B. E.; Cranmer, K.; Cristinziani, M.; Crosetti, G.; Crupi, R.; Crépé-Renaudin, S.; Cuenca Almenar, C.; Cuhadar Donszelmann, T.; Cuneo, S.; Curatolo, M.; Curtis, C. J.; Cwetanski, P.; Czirr, H.; Czyczula, Z.; D'Auria, S.; D'Onofrio, M.; D'Orazio, A.; da Rocha Gesualdi Mello, A.; da Silva, P. V. M.; da Via, C.; Dabrowski, W.; Dahlhoff, A.; Dai, T.; Dallapiccola, C.; Dallison, S. J.; Dam, M.; Dameri, M.; Damiani, D. S.; Danielsson, H. O.; Dankers, R.; Dannheim, D.; Dao, V.; Darbo, G.; Darlea, G. L.; Daum, C.; Dauvergne, J. P.; Davey, W.; Davidek, T.; Davidson, N.; Davidson, R.; Davies, M.; Davison, A. R.; Dawe, E.; Dawson, I.; Dawson, J. W.; Daya, R. K.; de, K.; de Asmundis, R.; de Castro, S.; de Cecco, S.; de Graat, J.; de Groot, N.; de Jong, P.; de La Cruz-Burelo, E.; de La Taille, C.; de Lotto, B.; de Mora, L.; de Nooij, L.; de Oliveira Branco, M.; de Pedis, D.; de Saintignon, P.; de Salvo, A.; de Sanctis, U.; de Santo, A.; de Vivie de Regie, J. B.; Dean, S.; Dedes, G.; Dedovich, D. V.; Degenhardt, J.; Dehchar, M.; Deile, M.; Del Papa, C.; Del Peso, J.; Del Prete, T.; Dell'Acqua, A.; Dell'Asta, L.; Della Pietra, M.; Della Volpe, D.; Delmastro, M.; Delpierre, P.; Delruelle, N.; Delsart, P. A.; Deluca, C.; Demers, S.; Demichev, M.; Demirkoz, B.; Deng, J.; Denisov, S. P.; Dennis, C.; Derendarz, D.; Derkaoui, J. E.; Derue, F.; Dervan, P.; Desch, K.; Deviveiros, P. O.; Dewhurst, A.; Dewilde, B.; Dhaliwal, S.; Dhullipudi, R.; di Ciaccio, A.; di Ciaccio, L.; di Girolamo, A.; di Girolamo, B.; di Luise, S.; di Mattia, A.; di Nardo, R.; di Simone, A.; di Sipio, R.; Diaz, M. A.; Diaz Gomez, M. M.; Diblen, F.; Diehl, E. B.; Dietl, H.; Dietrich, J.; Dietzsch, T. A.; Diglio, S.; Dindar Yagci, K.; Dingfelder, J.; Dionisi, C.; Dita, P.; Dita, S.; Dittus, F.; Djama, F.; Djilkibaev, R.; Djobava, T.; Do Vale, M. A. B.; Do Valle Wemans, A.; Doan, T. K. O.; Dobbs, M.; Dobinson, R.; Dobos, D.; Dobson, E.; Dobson, M.; Dodd, J.; Dogan, O. B.; Doglioni, C.; Doherty, T.; Doi, Y.; Dolejsi, J.; Dolenc, I.; Dolezal, Z.; Dolgoshein, B. A.; Dohmae, T.; Donadelli, M.; Donega, M.; Donini, J.; Dopke, J.; Doria, A.; Dos Anjos, A.; Dosil, M.; Dotti, A.; Dova, M. T.; Dowell, J. D.; Doxiadis, A. D.; Doyle, A. T.; Drasal, Z.; Drees, J.; Dressnandt, N.; Drevermann, H.; Driouichi, C.; Dris, M.; Drohan, J. G.; Dubbert, J.; Dubbs, T.; Dube, S.; Duchovni, E.; Duckeck, G.; Dudarev, A.; Dudziak, F.; Dührssen, M.; Duerdoth, I. P.; Duflot, L.; Dufour, M.-A.; Dunford, M.; Duran Yildiz, H.; Duxfield, R.; Dwuznik, M.; Dydak, F.; Dzahini, D.; Düren, M.; Ebke, J.; Eckert, S.; Eckweiler, S.; Edmonds, K.; Edwards, C. A.; Efthymiopoulos, I.; Ehrenfeld, W.; Ehrich, T.; Eifert, T.; Eigen, G.; Einsweiler, K.; Eisenhandler, E.; Ekelof, T.; El Kacimi, M.; Ellert, M.; Elles, S.; Ellinghaus, F.; Ellis, K.; Ellis, N.; Elmsheuser, J.; Elsing, M.; Ely, R.; Emeliyanov, D.; Engelmann, R.; Engl, A.; Epp, B.; Eppig, A.; Erdmann, J.; Ereditato, A.; Eriksson, D.; Ernst, J.; Ernst, M.; Ernwein, J.; Errede, D.; Errede, S.; Ertel, E.; Escalier, M.; Escobar, C.; Espinal Curull, X.; Esposito, B.; Etienne, F.; Etienvre, A. I.; Etzion, E.; Evangelakou, D.; Evans, H.; Fabbri, L.; Fabre, C.; Facius, K.; Fakhrutdinov, R. M.; Falciano, S.; Falou, A. C.; Fang, Y.; Fanti, M.; Farbin, A.; Farilla, A.; Farley, J.; Farooque, T.; Farrington, S. M.; Farthouat, P.; Fasching, D.; Fassnacht, P.; Fassouliotis, D.; Fatholahzadeh, B.; Fayard, L.; Fazio, S.; Febbraro, R.; Federic, P.; Fedin, O. L.; Fedorko, I.; Fedorko, W.; Fehling-Kaschek, M.; Feligioni, L.; Felzmann, C. U.; Feng, C.; Feng, E. J.; Fenyuk, A. B.; Ferencei, J.; Ferguson, D.; Ferland, J.; Fernandes, B.; Fernando, W.; Ferrag, S.; Ferrando, J.; Ferrara, V.; Ferrari, A.; Ferrari, P.; Ferrari, R.; Ferrer, A.; Ferrer, M. L.; Ferrere, D.; Ferretti, C.; Ferretto Parodi, A.; Ferro, F.; Fiascaris, M.; Fiedler, F.; Filipčič, A.; Filippas, A.; Filthaut, F.; Fincke-Keeler, M.; Fiolhais, M. C. N.; Fiorini, L.; Firan, A.; Fischer, G.; Fischer, P.; Fisher, M. J.; Fisher, S. M.; Flammer, J.; Flechl, M.; Fleck, I.; Fleckner, J.; Fleischmann, P.; Fleischmann, S.; Flick, T.; Flores Castillo, L. R.; Flowerdew, M. J.; Föhlisch, F.; Fokitis, M.; Fonseca Martin, T.; Fopma, J.; Forbush, D. A.; Formica, A.; Forti, A.; Fortin, D.; Foster, J. M.; Fournier, D.; Foussat, A.; Fowler, A. J.; Fowler, K.; Fox, H.; Francavilla, P.; Franchino, S.; Francis, D.; Frank, T.; Franklin, M.; Franz, S.; Fraternali, M.; Fratina, S.; French, S. T.; Froeschl, R.; Froidevaux, D.; Frost, J. A.; Fukunaga, C.; Fullana Torregrosa, E.; Fuster, J.; Gabaldon, C.; Gabizon, O.; Gadfort, T.; Gadomski, S.; Gagliardi, G.; Gagnon, P.; Galea, C.; Gallas, E. J.; Gallas, M. V.; Gallo, V.; Gallop, B. J.; Gallus, P.; Galyaev, E.; Gan, K. K.; Gao, Y. S.; Gapienko, V. A.; Gaponenko, A.; Garberson, F.; Garcia-Sciveres, M.; García, C.; García Navarro, J. E.; Gardner, R. W.; Garelli, N.; Garitaonandia, H.; Garonne, V.; Garvey, J.; Gatti, C.; Gaudio, G.; Gaumer, O.; Gaur, B.; Gauthier, L.; Gavrilenko, I. L.; Gay, C.; Gaycken, G.; Gayde, J.-C.; Gazis, E. N.; Ge, P.; Gee, C. N. P.; Geich-Gimbel, Ch.; Gellerstedt, K.; Gemme, C.; Gemmell, A.; Genest, M. H.; Gentile, S.; Georgatos, F.; George, S.; Gerlach, P.; Gershon, A.; Geweniger, C.; Ghazlane, H.; Ghez, P.; Ghodbane, N.; Giacobbe, B.; Giagu, S.; Giakoumopoulou, V.; Giangiobbe, V.; Gianotti, F.; Gibbard, B.; Gibson, A.; Gibson, S. M.; Gieraltowski, G. F.; Gilbert, L. M.; Gilchriese, M.; Gildemeister, O.; Gilewsky, V.; Gillberg, D.; Gillman, A. 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G.; Goy, C.; Grabowska-Bold, I.; Grabski, V.; Grafström, P.; Grah, C.; Grahn, K.-J.; Grancagnolo, F.; Grancagnolo, S.; Grassi, V.; Gratchev, V.; Grau, N.; Gray, H. M.; Gray, J. A.; Graziani, E.; Grebenyuk, O. G.; Greenfield, D.; Greenshaw, T.; Greenwood, Z. D.; Gregor, I. M.; Grenier, P.; Griesmayer, E.; Griffiths, J.; Grigalashvili, N.; Grillo, A. A.; Grimm, K.; Grinstein, S.; Grishkevich, Y. V.; Grivaz, J.-F.; Grognuz, J.; Groh, M.; Gross, E.; Grosse-Knetter, J.; Groth-Jensen, J.; Gruwe, M.; Grybel, K.; Guarino, V. J.; Guicheney, C.; Guida, A.; Guillemin, T.; Guindon, S.; Guler, H.; Gunther, J.; Guo, B.; Guo, J.; Gupta, A.; Gusakov, Y.; Gushchin, V. N.; Gutierrez, A.; Gutierrez, P.; Guttman, N.; Gutzwiller, O.; Guyot, C.; Gwenlan, C.; Gwilliam, C. B.; Haas, A.; Haas, S.; Haber, C.; Hackenburg, R.; Hadavand, H. K.; Hadley, D. 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A.; Parzefall, U.; Pasqualucci, E.; Passeri, A.; Pastore, F.; Pastore, Fr.; Pásztor, G.; Pataraia, S.; Patel, N.; Pater, J. R.; Patricelli, S.; Pauly, T.; Pecsy, M.; Pedraza Morales, M. I.; Peeters, S. J. M.; Peleganchuk, S. V.; Peng, H.; Pengo, R.; Penson, A.; Penwell, J.; Perantoni, M.; Perez, K.; Perez Cavalcanti, T.; Perez Codina, E.; Pérez García-Estañ, M. T.; Perez Reale, V.; Peric, I.; Perini, L.; Pernegger, H.; Perrino, R.; Perrodo, P.; Persembe, S.; Perus, P.; Peshekhonov, V. D.; Petereit, E.; Peters, O.; Petersen, B. A.; Petersen, J.; Petersen, T. C.; Petit, E.; Petridis, A.; Petridou, C.; Petrolo, E.; Petrucci, F.; Petschull, D.; Petteni, M.; Pezoa, R.; Phan, A.; Phillips, A. W.; Phillips, P. W.; Piacquadio, G.; Piccaro, E.; Piccinini, M.; Pickford, A.; Piegaia, R.; Pilcher, J. E.; Pilkington, A. D.; Pina, J.; Pinamonti, M.; Pinfold, J. L.; Ping, J.; Pinto, B.; Pirotte, O.; Pizio, C.; Placakyte, R.; Plamondon, M.; Plano, W. G.; Pleier, M.-A.; Pleskach, A. V.; Poblaguev, A.; Poddar, S.; Podlyski, F.; Poggioli, L.; Poghosyan, T.; Pohl, M.; Polci, F.; Polesello, G.; Policicchio, A.; Polini, A.; Poll, J.; Polychronakos, V.; Pomarede, D. M.; Pomeroy, D.; Pommès, K.; Pontecorvo, L.; Pope, B. G.; Popeneciu, G. A.; Popovic, D. S.; Poppleton, A.; Portell Bueso, X.; Porter, R.; Posch, C.; Pospelov, G. E.; Pospisil, S.; Potrap, I. N.; Potter, C. J.; Potter, C. T.; Poulard, G.; Poveda, J.; Prabhu, R.; Pralavorio, P.; Prasad, S.; Pravahan, R.; Prell, S.; Pretzl, K.; Pribyl, L.; Price, D.; Price, L. E.; Price, M. J.; Prichard, P. M.; Prieur, D.; Primavera, M.; Prokofiev, K.; Prokoshin, F.; Protopopescu, S.; Proudfoot, J.; Prudent, X.; Przysiezniak, H.; Psoroulas, S.; Ptacek, E.; Purdham, J.; Purohit, M.; Puzo, P.; Pylypchenko, Y.; Qian, J.; Qian, Z.; Qin, Z.; Quadt, A.; Quarrie, D. R.; Quayle, W. B.; Quinonez, F.; Raas, M.; Radescu, V.; Radics, B.; Rador, T.; Ragusa, F.; Rahal, G.; Rahimi, A. M.; Rajagopalan, S.; Rajek, S.; Rammensee, M.; Rammes, M.; Ramstedt, M.; Randrianarivony, K.; Ratoff, P. N.; Rauscher, F.; Rauter, E.; Raymond, M.; Read, A. L.; Rebuzzi, D. M.; Redelbach, A.; Redlinger, G.; Reece, R.; Reeves, K.; Reichold, A.; Reinherz-Aronis, E.; Reinsch, A.; Reisinger, I.; Reljic, D.; Rembser, C.; Ren, Z. L.; Renkel, P.; Rensch, B.; Rescigno, M.; Resconi, S.; Resende, B.; Reznicek, P.; Rezvani, R.; Richards, A.; Richter, R.; Richter-Was, E.; Ridel, M.; Rieke, S.; Rijpstra, M.; Rijssenbeek, M.; Rimoldi, A.; Rinaldi, L.; Rios, R. R.; Riu, I.; Rivoltella, G.; Rizatdinova, F.; Rizvi, E.; Roa Romero, D. A.; Robertson, S. H.; Robichaud-Veronneau, A.; Robinson, D.; Robinson, J. E. M.; Robinson, M.; Robson, A.; Rocha de Lima, J. G.; Roda, C.; Roda Dos Santos, D.; Rodier, S.; Rodriguez, D.; Rodriguez Garcia, Y.; Roe, A.; Roe, S.; Røhne, O.; Rojo, V.; Rolli, S.; Romaniouk, A.; Romanov, V. M.; Romeo, G.; Romero Maltrana, D.; Roos, L.; Ros, E.; Rosati, S.; Rose, M.; Rosenbaum, G. A.; Rosenberg, E. I.; Rosendahl, P. L.; Rosselet, L.; Rossetti, V.; Rossi, E.; Rossi, L. P.; Rossi, L.; Rotaru, M.; Roth, I.; Rothberg, J.; Rottländer, I.; Rousseau, D.; Royon, C. R.; Rozanov, A.; Rozen, Y.; Ruan, X.; Rubinskiy, I.; Ruckert, B.; Ruckstuhl, N.; Rud, V. I.; Rudolph, G.; Rühr, F.; Ruggieri, F.; Ruiz-Martinez, A.; Rulikowska-Zarebska, E.; Rumiantsev, V.; Rumyantsev, L.; Runge, K.; Runolfsson, O.; Rurikova, Z.; Rusakovich, N. A.; Rust, D. R.; Rutherfoord, J. P.; Ruwiedel, C.; Ruzicka, P.; Ryabov, Y. F.; Ryadovikov, V.; Ryan, P.; Rybkin, G.; Ryder, N. C.; Rzaeva, S.; Saavedra, A. F.; Sadeh, I.; Sadrozinski, H. F.-W.; Sadykov, R.; Safai Tehrani, F.; Sakamoto, H.; Salamanna, G.; Salamon, A.; Saleem, M.; Salihagic, D.; Salnikov, A.; Salt, J.; Salvachua Ferrando, B. M.; Salvatore, D.; Salvatore, F.; Salvucci, A.; Salzburger, A.; Sampsonidis, D.; Samset, B. H.; Sandaker, H.; Sander, H. G.; Sanders, M. P.; Sandhoff, M.; Sandhu, P.; Sandoval, T.; Sandstroem, R.; Sandvoss, S.; Sankey, D. P. C.; Sansoni, A.; Santamarina Rios, C.; Santoni, C.; Santonico, R.; Santos, H.; Saraiva, J. G.; Sarangi, T.; Sarkisyan-Grinbaum, E.; Sarri, F.; Sartisohn, G.; Sasaki, O.; Sasaki, T.; Sasao, N.; Satsounkevitch, I.; Sauvage, G.; Savard, P.; Savinov, V.; Savva, P.; Sawyer, L.; Saxon, D. H.; Says, L. P.; Sbarra, C.; Sbrizzi, A.; Scallon, O.; Scannicchio, D. A.; Schaarschmidt, J.; Schacht, P.; Schäfer, U.; Schaetzel, S.; Schaffer, A. C.; Schaile, D.; Schamberger, R. D.; Schamov, A. G.; Scharf, V.; Schegelsky, V. A.; Scheirich, D.; Scherzer, M. I.; Schiavi, C.; Schieck, J.; Schioppa, M.; Schlenker, S.; Schlereth, J. L.; Schmidt, E.; Schmidt, M. P.; Schmieden, K.; Schmitt, C.; Schmitz, M.; Schöning, A.; Schott, M.; Schouten, D.; Schovancova, J.; Schram, M.; Schreiner, A.; Schroeder, C.; Schroer, N.; Schroers, M.; Schuh, S.; Schuler, G.; Schultes, J.; Schultz-Coulon, H.-C.; Schumacher, J. W.; Schumacher, M.; Schumm, B. A.; Schune, Ph.; Schwanenberger, C.; Schwartzman, A.; Schweiger, D.; Schwemling, Ph.; Schwienhorst, R.; Schwierz, R.; Schwindling, J.; Scott, W. G.; Searcy, J.; Sedykh, E.; Segura, E.; Seidel, S. C.; Seiden, A.; Seifert, F.; Seixas, J. M.; Sekhniaidze, G.; Seliverstov, D. M.; Sellden, B.; Sellers, G.; Seman, M.; Semprini-Cesari, N.; Serfon, C.; Serin, L.; Seuster, R.; Severini, H.; Sevior, M. E.; Sfyrla, A.; Shabalina, E.; Shamim, M.; Shan, L. Y.; Shank, J. T.; Shao, Q. T.; Shapiro, M.; Shatalov, P. B.; Shaver, L.; Shaw, C.; Shaw, K.; Sherman, D.; Sherwood, P.; Shibata, A.; Shimizu, S.; Shimojima, M.; Shin, T.; Shmeleva, A.; Shochet, M. J.; Short, D.; Shupe, M. A.; Sicho, P.; Sidoti, A.; Siebel, A.; Siegert, F.; Siegrist, J.; Sijacki, Dj.; Silbert, O.; Silva, J.; Silver, Y.; Silverstein, D.; Silverstein, S. B.; Simak, V.; Simic, Lj.; Simion, S.; Simmons, B.; Simonyan, M.; Sinervo, P.; Sinev, N. B.; Sipica, V.; Siragusa, G.; Sisakyan, A. N.; Sivoklokov, S. Yu.; Sjölin, J.; Sjursen, T. B.; Skinnari, L. A.; Skovpen, K.; Skubic, P.; Skvorodnev, N.; Slater, M.; Slavicek, T.; Sliwa, K.; Sloan, T. J.; Sloper, J.; Smakhtin, V.; Smirnov, S. Yu.; Smirnova, L. N.; Smirnova, O.; Smith, B. C.; Smith, D.; Smith, K. M.; Smizanska, M.; Smolek, K.; Snesarev, A. A.; Snow, S. W.; Snow, J.; Snuverink, J.; Snyder, S.; Soares, M.; Sobie, R.; Sodomka, J.; Soffer, A.; Solans, C. A.; Solar, M.; Solc, J.; Soldevila, U.; Solfaroli Camillocci, E.; Solodkov, A. A.; Solovyanov, O. V.; Sondericker, J.; Soni, N.; Sopko, V.; Sopko, B.; Sorbi, M.; Sosebee, M.; Soukharev, A.; Spagnolo, S.; Spanò, F.; Spighi, R.; Spigo, G.; Spila, F.; Spiriti, E.; Spiwoks, R.; Spousta, M.; Spreitzer, T.; Spurlock, B.; St. Denis, R. D.; Stahl, T.; Stahlman, J.; Stamen, R.; Stanecka, E.; Stanek, R. W.; Stanescu, C.; Stapnes, S.; Starchenko, E. A.; Stark, J.; Staroba, P.; Starovoitov, P.; Staude, A.; Stavina, P.; Stavropoulos, G.; Steele, G.; Stefanidis, E.; Steinbach, P.; Steinberg, P.; Stekl, I.; Stelzer, B.; Stelzer, H. J.; Stelzer-Chilton, O.; Stenzel, H.; Stevenson, K.; Stewart, G. A.; Stockmanns, T.; Stockton, M. C.; Stodulski, M.; Stoerig, K.; Stoicea, G.; Stonjek, S.; Strachota, P.; Stradling, A. R.; Straessner, A.; Strandberg, J.; Strandberg, S.; Strandlie, A.; Strang, M.; Strauss, E.; Strauss, M.; Strizenec, P.; Ströhmer, R.; Strom, D. M.; Strong, J. A.; Stroynowski, R.; Strube, J.; Stugu, B.; Stumer, I.; Stupak, J.; Sturm, P.; Soh, D. A.; Su, D.; Subramania, S.; Sugaya, Y.; Sugimoto, T.; Suhr, C.; Suita, K.; Suk, M.; Sulin, V. V.; Sultansoy, S.; Sumida, T.; Sun, X.; Sundermann, J. E.; Suruliz, K.; Sushkov, S.; Susinno, G.; Sutton, M. R.; Suzuki, Y.; Sviridov, Yu. M.; Swedish, S.; Sykora, I.; Sykora, T.; Szeless, B.; Sánchez, J.; Ta, D.; Tackmann, K.; Taffard, A.; Tafirout, R.; Taga, A.; Taiblum, N.; Takahashi, Y.; Takai, H.; Takashima, R.; Takeda, H.; Takeshita, T.; Talby, M.; Talyshev, A.; Tamsett, M. C.; Tanaka, J.; Tanaka, R.; Tanaka, S.; Tanaka, S.; Tanaka, Y.; Tani, K.; Tannoury, N.; Tappern, G. P.; Tapprogge, S.; Tardif, D.; Tarem, S.; Tarrade, F.; Tartarelli, G. F.; Tas, P.; Tasevsky, M.; Tassi, E.; Tatarkhanov, M.; Taylor, C.; Taylor, F. E.; Taylor, G.; Taylor, G. N.; Taylor, W.; Teixeira Dias Castanheira, M.; Teixeira-Dias, P.; Temming, K. K.; Ten Kate, H.; Teng, P. K.; Tennenbaum-Katan, Y. D.; Terada, S.; Terashi, K.; Terron, J.; Terwort, M.; Testa, M.; Teuscher, R. J.; Tevlin, C. M.; Thadome, J.; Therhaag, J.; Theveneaux-Pelzer, T.; Thioye, M.; Thoma, S.; Thomas, J. P.; Thompson, E. N.; Thompson, P. D.; Thompson, P. D.; Thompson, A. S.; Thomson, E.; Thomson, M.; Thun, R. P.; Tic, T.; Tikhomirov, V. O.; Tikhonov, Y. A.; Timmermans, C. J. W. P.; Tipton, P.; Tique Aires Viegas, F. J.; Tisserant, S.; Tobias, J.; Toczek, B.; Todorov, T.; Todorova-Nova, S.; Toggerson, B.; Tojo, J.; Tokár, S.; Tokunaga, K.; Tokushuku, K.; Tollefson, K.; Tomoto, M.; Tompkins, L.; Toms, K.; Tonazzo, A.; Tong, G.; Tonoyan, A.; Topfel, C.; Topilin, N. D.; Torchiani, I.; Torrence, E.; Torró Pastor, E.; Toth, J.; Touchard, F.; Tovey, D. R.; Traynor, D.; Trefzger, T.; Treis, J.; Tremblet, L.; Tricoli, A.; Trigger, I. M.; Trincaz-Duvoid, S.; Trinh, T. N.; Tripiana, M. F.; Triplett, N.; Trischuk, W.; Trivedi, A.; Trocmé, B.; Troncon, C.; Trottier-McDonald, M.; Trzupek, A.; Tsarouchas, C.; Tseng, J. C.-L.; Tsiakiris, M.; Tsiareshka, P. V.; Tsionou, D.; Tsipolitis, G.; Tsiskaridze, V.; Tskhadadze, E. G.; Tsukerman, I. I.; Tsulaia, V.; Tsung, J.-W.; Tsuno, S.; Tsybychev, D.; Tua, A.; Tuggle, J. M.; Turala, M.; Turecek, D.; Turk Cakir, I.; Turlay, E.; Tuts, P. M.; Tykhonov, A.; Tylmad, M.; Tyndel, M.; Typaldos, D.; Tyrvainen, H.; Tzanakos, G.; Uchida, K.; Ueda, I.; Ueno, R.; Ugland, M.; Uhlenbrock, M.; Uhrmacher, M.; Ukegawa, F.; Unal, G.; Underwood, D. G.; Undrus, A.; Unel, G.; Unno, Y.; Urbaniec, D.; Urkovsky, E.; Urquijo, P.; Urrejola, P.; Usai, G.; Uslenghi, M.; Vacavant, L.; Vacek, V.; Vachon, B.; Vahsen, S.; Valderanis, C.; Valenta, J.; Valente, P.; Valentinetti, S.; Valkar, S.; Valladolid Gallego, E.; Vallecorsa, S.; Valls Ferrer, J. A.; van der Graaf, H.; van der Kraaij, E.; van der Poel, E.; van der Ster, D.; van Eijk, B.; van Eldik, N.; van Gemmeren, P.; van Kesteren, Z.; van Vulpen, I.; Vandelli, W.; Vandoni, G.; Vaniachine, A.; Vankov, P.; Vannucci, F.; Varela Rodriguez, F.; Vari, R.; Varnes, E. W.; Varouchas, D.; Vartapetian, A.; Varvell, K. E.; Vassilakopoulos, V. I.; Vazeille, F.; Vegni, G.; Veillet, J. J.; Vellidis, C.; Veloso, F.; Veness, R.; Veneziano, S.; Ventura, A.; Ventura, D.; Ventura, S.; Venturi, M.; Venturi, N.; Vercesi, V.; Verducci, M.; Verkerke, W.; Vermeulen, J. C.; Vertogardov, L.; Vetterli, M. C.; Vichou, I.; Vickey, T.; Viehhauser, G. H. A.; Viel, S.; Villa, M.; Villaplana Perez, M.; Vilucchi, E.; Vincter, M. G.; Vinek, E.; Vinogradov, V. B.; Virchaux, M.; Viret, S.; Virzi, J.; Vitale, A.; Vitells, O.; Vivarelli, I.; Vives Vaque, F.; Vlachos, S.; Vlasak, M.; Vlasov, N.; Vogel, A.; Vokac, P.; Volpi, M.; Volpini, G.; von der Schmitt, H.; von Loeben, J.; von Radziewski, H.; von Toerne, E.; Vorobel, V.; Vorobiev, A. P.; Vorwerk, V.; Vos, M.; Voss, R.; Voss, T. T.; Vossebeld, J. H.; Vovenko, A. S.; Vranjes, N.; Vranjes Milosavljevic, M.; Vrba, V.; Vreeswijk, M.; Vu Anh, T.; Vuillermet, R.; Vukotic, I.; Wagner, W.; Wagner, P.; Wahlen, H.; Wahrmund, S.; Wakabayashi, J.; Walbersloh, J.; Walch, S.; Walder, J.; Walker, R.; Walkowiak, W.; Wall, R.; Waller, P.; Wang, C.; Wang, H.; Wang, J.; Wang, J. C.; Wang, S. M.; Warburton, A.; Ward, C. P.; Warsinsky, M.; Wastie, R.; Watkins, P. M.; Watson, A. T.; Watson, M. F.; Watts, G.; Watts, S.; Waugh, A. T.; Waugh, B. M.; Weber, J.; Weber, M.; Weber, M. S.; Weber, P.; Weidberg, A. R.; Weingarten, J.; Weiser, C.; Wellenstein, H.; Wells, P. S.; Wen, M.; Wenaus, T.; Wendler, S.; Weng, Z.; Wengler, T.; Wenig, S.; Wermes, N.; Werner, M.; Werner, P.; Werth, M.; Wessels, M.; Whalen, K.; Wheeler-Ellis, S. J.; Whitaker, S. P.; White, A.; White, M. J.; Whitehead, S. R.; Whiteson, D.; Whittington, D.; Wicek, F.; Wicke, D.; Wickens, F. J.; Wiedenmann, W.; Wielers, M.; Wienemann, P.; Wiglesworth, C.; Wiik, L. A. M.; Wildauer, A.; Wildt, M. A.; Wilhelm, I.; Wilkens, H. G.; Will, J. Z.; Williams, E.; Williams, H. H.; Willis, W.; Willocq, S.; Wilson, J. A.; Wilson, M. G.; Wilson, A.; Wingerter-Seez, I.; Winkelmann, S.; Winklmeier, F.; Wittgen, M.; Wolter, M. W.; Wolters, H.; Wooden, G.; Wosiek, B. K.; Wotschack, J.; Woudstra, M. J.; Wraight, K.; Wright, C.; Wrona, B.; Wu, S. L.; Wu, X.; Wulf, E.; Wunstorf, R.; Wynne, B. M.; Xaplanteris, L.; Xella, S.; Xie, S.; Xie, Y.; Xu, C.; Xu, D.; Xu, G.; Yabsley, B.; Yamada, M.; Yamamoto, A.; Yamamoto, K.; Yamamoto, S.; Yamamura, T.; Yamaoka, J.; Yamazaki, T.; Yamazaki, Y.; Yan, Z.; Yang, H.; Yang, S.; Yang, U. K.; Yang, Y.; Yang, Y.; Yang, Z.; Yanush, S.; Yao, W.-M.; Yao, Y.; Yasu, Y.; Ye, J.; Ye, S.; Yilmaz, M.; Yoosoofmiya, R.; Yorita, K.; Yoshida, R.; Young, C.; Youssef, S.; Yu, D.; Yu, J.; Yu, J.; Yuan, L.; Yurkewicz, A.; Zaets, V. G.; Zaidan, R.; Zaitsev, A. M.; Zajacova, Z.; Zalite, Yo. K.; Zanello, L.; Zarzhitsky, P.; Zaytsev, A.; Zdrazil, M.; Zeitnitz, C.; Zeller, M.; Zema, P. F.; Zemla, A.; Zendler, C.; Zenin, A. V.; Zenin, O.; Ženiš, T.; Zenonos, Z.; Zenz, S.; Zerwas, D.; Zevi Della Porta, G.; Zhan, Z.; Zhang, H.; Zhang, J.; Zhang, X.; Zhang, Z.; Zhao, L.; Zhao, T.; Zhao, Z.; Zhemchugov, A.; Zheng, S.; Zhong, J.; Zhou, B.; Zhou, N.; Zhou, Y.; Zhu, C. G.; Zhu, H.; Zhu, Y.; Zhuang, X.; Zhuravlov, V.; Zieminska, D.; Zilka, B.; Zimmermann, R.; Zimmermann, S.; Zimmermann, S.; Ziolkowski, M.; Zitoun, R.; Živković, L.; Zmouchko, V. V.; Zobernig, G.; Zoccoli, A.; Zolnierowski, Y.; Zsenei, A.; Zur Nedden, M.; Zutshi, V.; Zwalinski, L.

2011-06-01

Measurements of charged particle distributions, sensitive to the underlying event, have been performed with the ATLAS detector at the LHC. The measurements are based on data collected using a minimum-bias trigger to select proton-proton collisions at center-of-mass energies of 900 GeV and 7 TeV. The “underlying event” is defined as those aspects of a hadronic interaction attributed not to the hard scattering process, but rather to the accompanying interactions of the rest of the proton. Three regions are defined in azimuthal angle with respect to the highest transverse momentum charged particle in the event, such that the region transverse to the dominant momentum-flow is most sensitive to the underlying event. In each of these regions, distributions of the charged particle multiplicity, transverse momentum density, and average pT are measured. The data show generally higher underlying event activity than that predicted by Monte Carlo models tuned to pre-LHC data.

Contact technique and concussions in the South African under-18 Coca-Cola Craven Week Rugby tournament.

PubMed

Hendricks, Sharief; O'connor, Sam; Lambert, Michael; Brown, James; Burger, Nicholas; Mc Fie, Sarah; Readhead, Clint; Viljoen, Wayne

2015-01-01

In rugby union, understanding the techniques and events leading to concussions is important because of the nature of the injury and the severity and potential long-term consequences, particularly in junior players. Proper contact technique is a prerequisite for successful participation in rugby and is a major factor associated with injury. However, the execution of proper contact technique and its relationship to injury has yet to be studied in matches. Therefore, the aim of this study was to compare contact techniques leading to concussion with a representative sample of similarly matched non-injury (NI) contact events. Injury surveillance was conducted at the 2011-2013 under-18 Craven Week Rugby tournaments. Video footage of 10 concussive events (5 tackle, 4 ruck and 1 aerial collision) and 83 NI events were identified (19 tackle, 61 ruck and 3 aerial collisions). Thereafter, each phase of play was analysed using standardised technical proficiency criteria. Overall score for ruck proficiency in concussive events was 5.67 (out of a total of 15) vs. 6.98 for NI events (n = 54) (effect size = 0.52, small). Overall average score for tackler proficiency was 7.25 (n = 4) and 6.67 (n = 15) for injury and NI tackles, respectively (out of 16) (effect size = 0.19, trivial). This is the first study to compare concussion injury contact technique to a player-matched sample of NI contact techniques. Certain individual technical criteria had an effect towards an NI outcome, and others had an effect towards a concussive event, highlighting that failure to execute certain techniques may substantially increase the opportunity for concussion.

When does the future begin? Time metrics matter, connecting present and future selves.

PubMed

Lewis, Neil A; Oyserman, Daphna

2015-06-01

People assume they should attend to the present; their future self can handle the future. This seemingly plausible rule of thumb can lead people astray, in part because some future events require current action. In order for the future to energize and motivate current action, it must feel imminent. To create this sense of imminence, we manipulated time metric--the units (e.g., days, years) in which time is considered. People interpret accessible time metrics in two ways: If preparation for the future is under way (Studies 1 and 2), people interpret metrics as implying when a future event will occur. If preparation is not under way (Studies 3-5), they interpret metrics as implying when preparation should start (e.g., planning to start saving 4 times sooner for a retirement in 10,950 days instead of 30 years). Time metrics mattered not because they changed how distal or important future events felt (Study 6), but because they changed how connected and congruent their current and future selves felt (Study 7). © The Author(s) 2015.

The role of repetitive thought in determining posttraumatic growth and distress following interpersonal trauma.

PubMed

Allbaugh, Lucy Jane; Wright, Margaret O'Dougherty; Folger, Susan F

2016-01-01

Repetitive thought (RT) strategies have been linked to a range of negative outcomes following traumatic interpersonal events but are proposed to serve an adaptive function under particular circumstances. This study examined outcomes following RT within a transdiagnostic framework, and explored the potentially adaptive nature of trait-like and event-related RT. The centrality of a traumatic event to one's identity was explored as a context under which the adaptive nature of RT might change. Young adults with interpersonal violence experiences (N = 163) reported use of trait-like and event-related RT, centrality of the event, depressive, anxious, and posttraumatic stress symptoms (PTSS), posttraumatic depreciation and posttraumatic growth. Hierarchical multiple regression analyses were used to examine main and moderating effects of four types of RT and event centrality on outcome variables. Centrality positively predicted depressive symptoms and PTSS, depreciation, and growth. Brooding RT positively predicted all negative outcomes. Reflecting RT positively predicted anxious symptoms and PTSS and depreciation. Only deliberate RT positively predicted growth. Centrality did not moderate any examined relationships. Findings highlight the importance of addressing specific types of RT in interventions with survivors and of considering centrality as a robust contributor to outcomes following interpersonal violence.

Does organisational justice protect from sickness absence following a major life event? A Finnish public sector study.

PubMed

Elovainio, M; Kivimäki, M; Linna, A; Brockner, J; van den Bos, K; Greenberg, J; Pentti, J; Virtanen, M; Vahtera, J

2010-05-01

It has been shown that fairness perceptions have a strong impact on health, especially under conditions of great work stress. The aim of this study was to extend previous research in studying whether working in high justice workplace would protect from health effects following environmental stressors outside work. Using a prospective longitudinal design, the relationships between organisational justice and sickness-related absences both before and after a major life event among 25 459 public sector employees working in 2551 work units were studied. Sickness absences covered the period from 36 months before the event until 30 months after the event. The increase in sickness absences after the event was larger and stayed at a higher level even 30 months after the event, among those who perceived the management practices in their work unit to be relatively unfair. Similar patterns were found for each of the distributive, procedural and interactional dimensions of organisational justice. Fair organisational and managerial procedures may buffer the negative health effects of psychosocial health risks outside work.

The Relative Importance of Spatial Versus Temporal Structure in the Perception of Biological Motion: An Event-Related Potential Study

ERIC Educational Resources Information Center

Hirai, Masahiro; Hiraki, Kazuo

2006-01-01

We investigated how the spatiotemporal structure of animations of biological motion (BM) affects brain activity. We measured event-related potentials (ERPs) during the perception of BM under four conditions: normal spatial and temporal structure; scrambled spatial and normal temporal structure; normal spatial and scrambled temporal structure; and…

A Survey of Adverse Event Reporting Practices Among US Healthcare Professionals.

PubMed

Stergiopoulos, Stella; Brown, Carrie A; Felix, Thomas; Grampp, Gustavo; Getz, Kenneth A

2016-11-01

The under-reporting of adverse drug events (ADEs) is an international health concern. A number of studies have assessed the root causes but, to our knowledge, little information exists relating under-reporting to practices and systems used for the recording and tracking of drug-related adverse event observations in ambulatory settings, institutional settings, and retail pharmacies. Our objective was to explore the process for reporting ADEs in US hospitals, ambulatory settings, and retail pharmacies; to explore gaps and inconsistencies in the reporting process; and to identify the causes of under-reporting ADEs in these settings. The Tufts Center for the Study of Drug Development (Tufts CSDD) interviewed 11 thought leaders and conducted a survey between May and August 2014 among US-based healthcare providers (HCPs) in diverse settings to assess their experiences with, and processes for, reporting ADEs. A total of 123 individuals completed the survey (42 % were pharmacists; 27 % were nurses; 15 % were physicians; and 16 % were classified as 'other'). HCPs indicated that the main reasons for under-reporting were difficulty in determining the cause of the ADE, given that most patients receive multiple therapies simultaneously (66 % of respondents); that HCPs lack sufficient time to report ADEs (63 % of respondents); poor integration of ADE-reporting systems (53 % of respondents); and uncertainty about reporting procedures (52 % of respondents). The results of this pilot study identify that key factors contributing to the under-reporting of ADEs relate to a lack of standardized process, a lack of training and education, and a lack of integrated health information technologies.

Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study.

PubMed

Maund, Emma; Tendal, Britta; Hróbjartsson, Asbjørn; Lundh, Andreas; Gøtzsche, Peter C

2014-06-04

To assess the effects of coding and coding conventions on summaries and tabulations of adverse events data on suicidality within clinical study reports. Systematic electronic search for adverse events of suicidality in tables, narratives, and listings of adverse events in individual patients within clinical study reports. Where possible, for each event we extracted the original term reported by the investigator, the term as coded by the medical coding dictionary, medical coding dictionary used, and the patient's trial identification number. Using the patient's trial identification number, we attempted to reconcile data on the same event between the different formats for presenting data on adverse events within the clinical study report. 9 randomised placebo controlled trials of duloxetine for major depressive disorder submitted to the European Medicines Agency for marketing approval. Clinical study reports obtained from the EMA in 2011. Six trials used the medical coding dictionary COSTART (Coding Symbols for a Thesaurus of Adverse Reaction Terms) and three used MedDRA (Medical Dictionary for Regulatory Activities). Suicides were clearly identifiable in all formats of adverse event data in clinical study reports. Suicide attempts presented in tables included both definitive and provisional diagnoses. Suicidal ideation and preparatory behaviour were obscured in some tables owing to the lack of specificity of the medical coding dictionary, especially COSTART. Furthermore, we found one event of suicidal ideation described in narrative text that was absent from tables and adverse event listings of individual patients. The reason for this is unclear, but may be due to the coding conventions used. Data on adverse events in tables in clinical study reports may not accurately represent the underlying patient data because of the medical dictionaries and coding conventions used. In clinical study reports, the listings of adverse events for individual patients and narratives of adverse events can provide additional information, including original investigator reported adverse event terms, which can enable a more accurate estimate of harms. © Maund et al 2014.

Separation of Benign and Malicious Network Events for Accurate Malware Family Classification

DTIC Science & Technology

2015-09-28

use Kullback - Leibler (KL) divergence [15] to measure the information ...related work in an important aspect concerning the order of events. We use n-grams to capture the order of events, which exposes richer information about...DISCUSSION Using n-grams on higher level network events helps under- stand the underlying operation of the malware, and provides a good feature set

Counting Unfolding Events in Stretched Helices with Induced Oscillation by Optical Tweezers

NASA Astrophysics Data System (ADS)

Bacabac, Rommel Gaud; Otadoy, Roland

Correlation measures based on embedded probe fluctuations, single or paired, are now widely used for characterizing the viscoelastic properties of biological samples. However, more robust applications using this technique are still lacking. Considering that the study of living matter routinely demonstrates new and complex phenomena, mathematical and experimental tools for analysis have to catch up in order to arrive at newer insights. Therefore, we derive ways of probing non-equilibrium events in helical biopolymers provided by stretching beyond thermal forces. We generalize, for the first time, calculations for winding turn probabilities to account for unfolding events in single fibrous biopolymers and globular proteins under tensile stretching using twin optical traps. The approach is based on approximating the ensuing probe fluctuations as originating from a damped harmonic oscillator under oscillatory forcing.

Jet and underlying event properties as a function of charged-particle multiplicity in proton-proton collisions at [Formula: see text].

PubMed

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Characteristics of multi-particle production in proton-proton collisions at [Formula: see text] are studied as a function of the charged-particle multiplicity, N ch . The produced particles are separated into two classes: those belonging to jets and those belonging to the underlying event. Charged particles are measured with pseudorapidity | η |<2.4 and transverse momentum p T >0.25 GeV/ c . Jets are reconstructed from charged-particles only and required to have p T >5 GeV/ c . The distributions of jet p T , average p T of charged particles belonging to the underlying event or to jets, jet rates, and jet shapes are presented as functions of N ch and compared to the predictions of the pythia and herwig event generators. Predictions without multi-parton interactions fail completely to describe the N ch -dependence observed in the data. For increasing N ch , pythia systematically predicts higher jet rates and harder p T spectra than seen in the data, whereas herwig shows the opposite trends. At the highest multiplicity, the data-model agreement is worse for most observables, indicating the need for further tuning and/or new model ingredients.

Event generator tunes obtained from underlying event and multiparton scattering measurements

DOE PAGES

Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; ...

2016-03-17

Here, new sets of parameters (“tunes”) for the underlying-event (UE) modelling of the pythia8, pythia6 and herwig++ Monte Carlo event generators are constructed using different parton distribution functions. Combined fits to CMS UE proton–proton (more » $$\\mathrm {p}\\mathrm {p}$$ ) data at $$\\sqrt{s} = 7\\,\\text {TeV} $$ and to UE proton–antiproton ( $$\\mathrm {p}\\overline{\\mathrm{p}} $$ ) data from the CDF experiment at lower $$\\sqrt{s}$$ , are used to study the UE models and constrain their parameters, providing thereby improved predictions for proton–proton collisions at 13 $$\\,\\text {TeV}$$ . In addition, it is investigated whether the values of the parameters obtained from fits to UE observables are consistent with the values determined from fitting observables sensitive to double-parton scattering processes. Finally, comparisons are presented of the UE tunes to “minimum bias” (MB) events, multijet, and Drell–Yan ( $$ \\mathrm{q} \\overline{\\mathrm{q}} \\rightarrow \\mathrm{Z}/ \\gamma ^* \\rightarrow $$ lepton-antilepton+jets) observables at 7 and 8 $$\\,\\text {TeV}$$ , as well as predictions for MB and UE observables at 13 $$\\,\\text {TeV}$$ .« less

Safety of herbal products in Thailand: an analysis of reports in the thai health product vigilance center database from 2000 to 2008.

PubMed

Saokaew, Surasak; Suwankesawong, Wimon; Permsuwan, Unchalee; Chaiyakunapruk, Nathorn

2011-04-01

The use of herbal products continues to expand rapidly across the world and concerns regarding the safety of these products have been raised. In Thailand, Thai Vigibase, developed by the Health Product Vigilance Center (HPVC) under the Thai Food and Drug Administration, is the national database that collates reports from health product surveillance systems and programmes. Thai Vigibase can be used to identify signals of adverse events in patients receiving herbal products. The purpose of the study was to describe the characteristics of reported adverse events in patients receiving herbal products in Thailand. Thai Vigibase data from February 2000 to December 2008 involving adverse events reported in association with herbal products were used. This database includes case reports submitted through the spontaneous reporting system and intensive monitoring programmes. Under the spontaneous reporting system, adverse event reports are collected nationwide via a national network of 22 regional centres covering more than 800 public and private hospitals, and health service centres. An intensive monitoring programme was also conducted to monitor the five single herbal products listed in the Thai National List of Essential Medicines (NLEM), while another intensive monitoring programme was developed to monitor the four single herbal products that were under consideration for inclusion in the NLEM. The database contained patient demographics, adverse events associated with herbal products, and details on seriousness, causality and quality of reports. Descriptive statistics were used for data analyses. A total of 593 reports with 1868 adverse events involving 24 different products were made during the study period. The age range of individuals was 1-86 years (mean 47 years). Most case reports were obtained from the intensive monitoring programme. Of the reports, 72% involved females. The herbal products for which adverse events were frequently reported were products containing turmeric (44%), followed by andrographis (10%), veld grape (10%), pennywort (7%), plai (6%), jewel vine (6%), bitter melon (5%) and snake plant (5%). Gastrointestinal problems were the most common adverse effect reported. Serious adverse events included Stevens-Johnson syndrome, anaphylactic shock and exfoliative dermatitis. Adverse event reports on herbals products were diverse, with most of them being reported through intensive monitoring programmes. Thai Vigibase is a potentially effective data source for signal detection of adverse events associated with herbal products.

When an event sparks behavior change: an introduction to the sentinel event method of dynamic model building and its application to emergency medicine.

PubMed

Boudreaux, Edwin D; Bock, Beth; O'Hea, Erin

2012-03-01

Experiencing a negative consequence related to one's health behavior, like a medical problem leading to an emergency department (ED) visit, can promote behavior change, giving rise to the popular concept of the "teachable moment." However, the mechanisms of action underlying this process of change have received scant attention. In particular, most existing health behavior theories are limited in explaining why such events can inspire short-term change in some and long-term change in others. Expanding on recommendations published in the 2009 Academic Emergency Medicine consensus conference on public health in emergency medicine (EM), we propose a new method for developing conceptual models that explain how negative events, like medical emergencies, influence behavior change, called the Sentinel Event Method. The method itself is atheoretical; instead, it defines steps to guide investigations that seek to relate specific consequences or events to specific health behaviors. This method can be used to adapt existing health behavior theories to study the event-behavior change relationship or to guide formulation of completely new conceptual models. This paper presents the tenets underlying the Sentinel Event Method, describes the steps comprising the process, and illustrates its application to EM through an example of a cardiac-related ED visit and tobacco use. © 2012 by the Society for Academic Emergency Medicine.

Situation and person attributions under spontaneous and intentional instructions: an fMRI study

PubMed Central

Kestemont, Jenny; Vandekerckhove, Marie; Ma, Ning; Van Hoeck, Nicole

2013-01-01

This functional magnetic resonance imaging (fMRI) research explores how observers make causal beliefs about an event in terms of the person or situation. Thirty-four participants read various short descriptions of social events that implied either the person or the situation as the cause. Half of them were explicitly instructed to judge whether the event was caused by something about the person or the situation (intentional inferences), whereas the other half was instructed simply to read the material carefully (spontaneous inferences). The results showed common activation in areas related to mentalizing, across all types of causes or instructions (posterior superior temporal sulcus, temporo-parietal junction, precuneus). However, the medial prefrontal cortex was activated only under spontaneous instructions, but not under intentional instruction. This suggests a bias toward person attributions (e.g. fundamental attribution bias). Complementary to this, intentional situation attributions activated a stronger and more extended network compared to intentional person attributions, suggesting that situation attributions require more controlled, extended and broader processing of the information. PMID:22345370

Using naturalistic driving data to explore the association between traffic safety-related events and crash risk at driver level.

PubMed

Wu, Kun-Feng; Aguero-Valverde, Jonathan; Jovanis, Paul P

2014-11-01

There has been considerable research conducted over the last 40 years using traffic safety-related events to support road safety analyses. Dating back to traffic conflict studies from the 1960s these observational studies of driver behavior have been criticized due to: poor quality data; lack of available and useful exposure measures linked to the observations; the incomparability of self-reported safety-related events; and, the difficulty in assessing culpability for safety-related events. This study seeks to explore the relationships between driver characteristics and traffic safety-related events, and between traffic safety-related events and crash involvement while mitigating some of those limitations. The Virginia Tech Transportation Institute 100-Car Naturalistic Driving Study dataset, in which the participants' vehicles were instrumented with various cameras and sensors during the study period, was used for this study. The study data set includes 90 drivers observed for 12-13 months driving. This study focuses on single vehicle run-off-road safety-related events only, including 14 crashes and 182 safety-related events (30 near crashes, and 152 crash-relevant incidents). Among the findings are: (1) drivers under age 25 are significantly more likely to be involved in safety-related events and crashes; and (2) significantly positive correlations exist between crashes, near crashes, and crash-relevant incidents. Although there is still much to learn about the factors affecting the positive correlation between safety-related events and crashes, a Bayesian multivariate Poisson log-normal model is shown to be useful to quantify the associations between safety-related events and crash risk while controlling for driver characteristics. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Comparison of the "Trigger" tool with the minimum basic data set for detecting adverse events in general surgery].

PubMed

Pérez Zapata, A I; Gutiérrez Samaniego, M; Rodríguez Cuéllar, E; Gómez de la Cámara, A; Ruiz López, P

Surgery is a high risk for the occurrence of adverse events (AE). The main objective of this study is to compare the effectiveness of the Trigger tool with the Hospital National Health System registration of Discharges, the minimum basic data set (MBDS), in detecting adverse events in patients admitted to General Surgery and undergoing surgery. Observational and descriptive retrospective study of patients admitted to general surgery of a tertiary hospital, and undergoing surgery in 2012. The identification of adverse events was made by reviewing the medical records, using an adaptation of "Global Trigger Tool" methodology, as well as the (MBDS) registered on the same patients. Once the AE were identified, they were classified according to damage and to the extent to which these could have been avoided. The area under the curve (ROC) were used to determine the discriminatory power of the tools. The Hanley and Mcneil test was used to compare both tools. AE prevalence was 36.8%. The TT detected 89.9% of all AE, while the MBDS detected 28.48%. The TT provides more information on the nature and characteristics of the AE. The area under the curve was 0.89 for the TT and 0.66 for the MBDS. These differences were statistically significant (P<.001). The Trigger tool detects three times more adverse events than the MBDS registry. The prevalence of adverse events in General Surgery is higher than that estimated in other studies. Copyright © 2017 SECA. Publicado por Elsevier España, S.L.U. All rights reserved.

Emotion intensity modulates perspective taking in men and women: an event-related potential study.

PubMed

Luo, Pinchao; Xu, Danna; Huang, Fengjuan; Wei, Fang

2018-06-13

When empathizing with another individual, one can imagine the individual's emotional states and how he or she perceives a situation. However, it is not known to what extent imagining the other differs from imagining oneself under different emotional intensity situations in both sexes. The present study investigated the regulatory effect of emotional intensity on perspective taking in men and women by event-related potentials. The participants were shown pictures of individuals in highly negative (HN), moderately negative, and neutral situations, and instructed to imagine the degree of pain perceived from either a self-perspective or an other-perspective. The results showed that there was no N2 differentiation between the self-perspective and other-perspective under all conditions. Nor was there late positive potential differentiation under moderately negative and neutral conditions in either sex. In contrast, late positive potential induced by HN pictures under the self-perspective was significantly larger than that under the other-perspective only in women. These results suggested that women tended to overestimate the pain of HN stimuli from a self-perspective than from an other-perspective.

The competing risks Cox model with auxiliary case covariates under weaker missing-at-random cause of failure.

PubMed

Nevo, Daniel; Nishihara, Reiko; Ogino, Shuji; Wang, Molin

2017-08-04

In the analysis of time-to-event data with multiple causes using a competing risks Cox model, often the cause of failure is unknown for some of the cases. The probability of a missing cause is typically assumed to be independent of the cause given the time of the event and covariates measured before the event occurred. In practice, however, the underlying missing-at-random assumption does not necessarily hold. Motivated by colorectal cancer molecular pathological epidemiology analysis, we develop a method to conduct valid analysis when additional auxiliary variables are available for cases only. We consider a weaker missing-at-random assumption, with missing pattern depending on the observed quantities, which include the auxiliary covariates. We use an informative likelihood approach that will yield consistent estimates even when the underlying model for missing cause of failure is misspecified. The superiority of our method over naive methods in finite samples is demonstrated by simulation study results. We illustrate the use of our method in an analysis of colorectal cancer data from the Nurses' Health Study cohort, where, apparently, the traditional missing-at-random assumption fails to hold.

48 CFR 833.213 - Obligation to continue performance.

Code of Federal Regulations, 2013 CFR

2013-10-01

... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...

48 CFR 833.213 - Obligation to continue performance.

Code of Federal Regulations, 2012 CFR

2012-10-01

... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...

48 CFR 833.213 - Obligation to continue performance.

Code of Federal Regulations, 2010 CFR

2010-10-01

... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...

48 CFR 833.213 - Obligation to continue performance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...

48 CFR 833.213 - Obligation to continue performance.

Code of Federal Regulations, 2011 CFR

2011-10-01

... in accordance with the contracting officer's decision in the event of a claim arising under a contract. Alternate I expands this authority, adding a requirement for the contractor to continue performance in the event of a claim relating to the contract. (b) In the event of a dispute not arising under...

Microscopic Evolution of Laboratory Volcanic Hybrid Earthquakes

PubMed Central

Ghaffari, H. O.; Griffith, W. A.; Benson, P. M.

2017-01-01

Characterizing the interaction between fluids and microscopic defects is one of the long-standing challenges in understanding a broad range of cracking processes, in part because they are so difficult to study experimentally. We address this issue by reexamining records of emitted acoustic phonon events during rock mechanics experiments under wet and dry conditions. The frequency spectrum of these events provides direct information regarding the state of the system. Such events are typically subdivided into high frequency (HF) and low frequency (LF) events, whereas intermediate “Hybrid” events, have HF onsets followed by LF ringing. At a larger scale in volcanic terranes, hybrid events are used empirically to predict eruptions, but their ambiguous physical origin limits their diagnostic use. By studying acoustic phonon emissions from individual microcracking events we show that the onset of a secondary instability–related to the transition from HF to LF–occurs during the fast equilibration phase of the system, leading to sudden increase of fluid pressure in the process zone. As a result of this squeezing process, a secondary instability akin to the LF event occurs. This mechanism is consistent with observations of hybrid earthquakes. PMID:28074878

Ocean Mixed Layer responses to intense meteorological events during HyMeX-SOP1 from a high-resolution ocean simulation

NASA Astrophysics Data System (ADS)

Lebeaupin Brossier, Cindy; Arsouze, Thomas; Béranger, Karine; Bouin, Marie-Noëlle; Bresson, Emilie; Ducrocq, Véronique; Giordani, Hervé; Nuret, Mathieu; Rainaud, Romain; Taupier-Letage, Isabelle

2014-12-01

The western Mediterranean Sea is a source of heat and humidity for the atmospheric low-levels in autumn. Large exchanges take place at the air-sea interface, especially during intense meteorological events, such as heavy precipitation and/or strong winds. The Ocean Mixed Layer (OML), which is quite thin at this time of year (∼ 20 m-depth), evolves rapidly under such intense fluxes. This study investigates the ocean responses under intense meteorological events that occurred during HyMeX SOP1 (5 September-6 November 2012). The OML conditions and tendencies are derived from a high-resolution ocean simulation using the sub-regional eddy-resolving NEMO-WMED36 model (1/36°-resolution), driven at the surface by hourly air-sea fluxes from the AROME-WMED forecasts (2.5 km-resolution). The high space-time resolution of the atmospheric forcing allows the highly variable surface fluxes, which induce rapid changes in the OML, to be well represented and linked to small-scale atmospheric processes. First, the simulation results are compared to ocean profiles from several platforms obtained during the campaign. Then, this study focuses on the short-term OML evolution during three events. In particular, we examine the OML cooling and mixing under strong wind events, potentially associated with upwelling, as well as the surface freshening under heavy precipitation events, producing low-salinity lenses. Tendencies demonstrate the major role of the surface forcing in the temperature and/or salinity anomaly formation. At the same time, mixing [restratification] rapidly occurs. As expected, the sign of this tendency term is very dependent on the local vertical stratification which varies at fine scale in the Mediterranean. It also controls [disables] the vertical propagation. In the Alboran Sea, the strong dynamics redistribute the OML anomalies, sometimes up to 7 days after their formation. Elsewhere, despite local amplitude modulations due to internal wave excitation by strong winds, the integrated effect of the horizontal advection is almost null on the anomalies' spread and decay. Finally, diffusion has a small contribution.

Effect of Oral Midazolam Premedication on Children's Co-operation Before General Anesthesia in Pediatric Dentistry.

PubMed

Kaviani, Nasser; Shahtusi, Mina; Haj Norousali Tehrani, Maryam; Nazari, Sara

2014-09-01

Premedication is expedient in reducing the psychological trauma from recalling the unpleasant pre-anesthetic phases, hence, inducing a trouble-free anesthesia. This study aimed to determine the effectiveness of oral midazolam in co-operation of the subjects before general anesthesia and in recalling the pre-anesthetic phases, performed on children candidate for dental treatment under general anesthesia. In this prospective clinical trial study, 62 healthy non-cooperative children, candidate for dental treatment under general anesthesia, were randomly divided into study and control groups. The children received 20ml orange juice, 20 minutes before starting the anesthesia. The juice of the test group contained 0.5mg/kg of midazolam and that of the control group included no medication. The induction and the maintenance process of anesthesia were similar in both groups. The manner of subjects when separated from parents, their cooperation during intravenous catheterization, and recalling the pre-anesthetic events were recorded. Data were analyzed by adopting chi-square and Mann-Whitney tests. Most of the children in the test group had a comfortable separation from parents, restful IV catheterization and 90% of the subjects did not recall the pre-anesthetic events. Under the circumstances of this study, it could be concluded that 0.5mg/kg oral midazolam premedication is effective for comfortable separation of children from parents and restful IV catheterization and also forgetting the pre-anesthetic events.

The stressed eyewitness: the interaction of thematic arousal and post-event stress in memory for central and peripheral event information

PubMed Central

Echterhoff, Gerald; Wolf, Oliver T.

2012-01-01

Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic) arousal and post-event stress interact to selectively enhance eyewitnesses' memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (1) the stimuli are encoded under arousal (vs. non-arousal), and (2) stress is experienced soon after the encoding episode. We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test (TSST). Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant post-event stress × thematic arousal × centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation. PMID:22936900

The stressed eyewitness: the interaction of thematic arousal and post-event stress in memory for central and peripheral event information.

PubMed

Echterhoff, Gerald; Wolf, Oliver T

2012-01-01

Both arousal during the encoding of stimuli and subsequent stress can affect memory, often by increasing memory for important or central information. We explored whether event-based (thematic) arousal and post-event stress interact to selectively enhance eyewitnesses' memory for the central aspects of an observed incident. Specifically, we argue that memory for stimuli should be enhanced when (1) the stimuli are encoded under arousal (vs. non-arousal), and (2) stress is experienced soon after the encoding episode. We designed an experiment that extended previous research by manipulating arousal without changing the stimulus material, distinguishing between central and peripheral event information, and using a dynamic, life-like event instead of static pictures. After watching a video depicting a burglary under high or low thematic arousal, psychosocial stress was induced or not induced by the Trier Social Stress Test (TSST). Salivary cortisol was measured at standard intervals. Consistent with our prediction, we found a significant post-event stress × thematic arousal × centrality interaction, indicating that the recognition advantage for central event items over peripheral event items was most pronounced under both high thematic arousal and post-event stress. Because stress was induced after encoding this interaction cannot be explained by possible differences at encoding, such as narrowed attention. The centrality effect of post-event stress under high thematic arousal was statistically mediated by the cortisol increase, which suggests a key role of the stress hormone. We discuss implications of our findings for psychological and neuroscientific theories of emotional memory formation.

Perceiving Control Over Aversive and Fearful Events Can Alter How We Experience Those Events: An Investigation of Time Perception in Spider-Fearful Individuals

PubMed Central

Buetti, Simona; Lleras, Alejandro

2012-01-01

We used a time perception task to study the effects of the subjective experience of control on emotion and cognitive processing. This task is uniquely sensitive to the emotionality of the stimuli: high-arousing negative stimuli are perceived as lasting longer than high-arousing positive events, while the opposite pattern is observed for low-arousing stimuli. We evaluated the temporal distortions of emotionally charged events in non-anxious (Experiments 1 and 5) and spider-fearful individuals (Experiments 2–4). Participants were shown images of varying durations between 400 and 1600 ms and were asked to report if the perceived duration of the image seemed closer to a short (400 ms) or to a long (1600 ms) standard duration. Our results replicate previous findings showing that the emotional content of the image modulated the perceived duration of that image. More importantly, we studied whether giving participants the illusion that they have some control over the emotional content of the images could eliminate this temporal distortion. Results confirmed this hypothesis, even though our participant population was composed of highly reactive emotional individuals (spider-fearful) facing fear-related images (spiders). Further, we also showed that under conditions of little-to-no control, spider-fearful individuals perceive temporal distortions in a distinct manner from non-anxious participants: the duration of events was entirely determined by the valence of the events, rather than by the typical valence × arousal interaction. That is, spider-fearful participants perceived negative events as lasting longer than positive events, regardless of their level of arousal. Finally, we also showed that under conditions of cognitive dissonance, control can eliminate temporal distortions of low arousal events, but not of high-arousing events, providing an important boundary condition to the otherwise positive effects of control on time estimation. PMID:23060824

Assessing exposure risk for dust storm events-associated lung function decrement in asthmatics and implications for control

NASA Astrophysics Data System (ADS)

Hsieh, Nan-Hung; Liao, Chung-Min

2013-04-01

Asian dust storms (ADS) events are seasonally-based meteorological phenomena that exacerbate chronic respiratory diseases. The purpose of this study was to assess human health risk from airborne dust exposure during ADS events in Taiwan. A probabilistic risk assessment framework was developed based on exposure and experimental data to quantify ADS events induced lung function decrement. The study reanalyzed experimental data from aerosol challenge in asthmatic individuals to construct the dose-response relationship between inhaled dust aerosol dose and decreasing percentage of forced expiratory volume in 1 s (%FEV1). An empirical lung deposition model was used to predict deposition fraction for size specific dust aerosols in pulmonary regions. The toxicokinetic and toxicodynamic models were used to simulate dust aerosols binding kinetics in lung airway in that %FEV1 change was also predicted. The mask respirators were applied to control the inhaled dose under dust aerosols exposure. Our results found that only 2% probability the mild ADS events were likely to cause %FEV1 decrement higher than 5%. There were 50% probability of decreasing %FEV1 exceeding 16.9, 18.9, and 7.1% in north, center, and south Taiwan under severe ADS events, respectively. Our result implicates that the use of activated carbon of mask respirators has the best efficacy for reducing inhaled dust aerosol dose, by which the %FEV1 decrement can be reduced up to less than 1%.

On Effort and Achievement of Business Undergraduate and Graduate Students under a Disastrous Event

ERIC Educational Resources Information Center

Mok, Wai Yin; Mok, Jonathan Rex; Cheung, Kit Yee

2016-01-01

The 2011 tornado event in Alabama left college students with a choice to be exempt of their final examinations or participate in an attempt to improve their overall grades. This incident provided an opportunity to conduct an observational study with the goal of measuring the academic effort of business undergraduate and graduate students. The…

Suggestibility under Pressure: Theory of Mind, Executive Function, and Suggestibility in Preschoolers

ERIC Educational Resources Information Center

Karpinski, Aryn C.; Scullin, Matthew H.

2009-01-01

Eighty preschoolers, ages 3 to 5 years old, completed a 4-phase study in which they experienced a live event and received a pressured, suggestive interview about the event a week later. Children were also administered batteries of theory of mind and executive function tasks, as well as the Video Suggestibility Scale for Children (VSSC), which…

Children's Representation and Imitation of Events: How Goal Organization Influences 3-Year-Old Children's Memory for Action Sequences

ERIC Educational Resources Information Center

Loucks, Jeff; Mutschler, Christina; Meltzoff, Andrew N.

2017-01-01

Children's imitation of adults plays a prominent role in human cognitive development. However, few studies have investigated how children represent the complex structure of observed actions which underlies their imitation. We integrate theories of action segmentation, memory, and imitation to investigate whether children's event representation is…

Operational momentum in large-number addition and subtraction by 9-month-olds.

PubMed

McCrink, Koleen; Wynn, Karen

2009-08-01

Recent studies on nonsymbolic arithmetic have illustrated that under conditions that prevent exact calculation, adults display a systematic tendency to overestimate the answers to addition problems and underestimate the answers to subtraction problems. It has been suggested that this operational momentum results from exposure to a culture-specific practice of representing numbers spatially; alternatively, the mind may represent numbers in spatial terms from early in development. In the current study, we asked whether operational momentum is present during infancy, prior to exposure to culture-specific representations of numbers. Infants (9-month-olds) were shown videos of events involving the addition or subtraction of objects with three different types of outcomes: numerically correct, too large, and too small. Infants looked significantly longer only at those incorrect outcomes that violated the momentum of the arithmetic operation (i.e., at too-large outcomes in subtraction events and too-small outcomes in addition events). The presence of operational momentum during infancy indicates developmental continuity in the underlying mechanisms used when operating over numerical representations.

Pediatric Admissions After Dental Care Under General Anesthesia: A Retrospective Study at a Tertiary Care Center.

PubMed

Lucy, Anna L; Gandhi, Roopa P; Gross, Lilyana; McNair, Bryan

2017-05-15

The purpose of this study was to identify factors associated with planned and unplanned pediatric hospital admissions following dental treatment under general anesthesia (DGA) in a tertiary care center. Dental and medical records of 100 subjects one to 20 years of age, with a known history of admission after DGA, were reviewed retrospectively for patient-, procedure-, and anesthesia-related factors as well as adverse events following DGA. During the review period (December 3, 2011 to June 30, 2015), 10,371 subjects underwent DGA, of which 100 subjects (less than one percent) required admission. A significant association was found between postoperative (PO) recovery time and unplanned admissions following DGA (P<0.001). Adverse post-operative events significantly associated with unplanned admissions included emesis (P=0.01) and hypoxia (P<0.001). Patients who were classified as having American Anesthesiology Association (ASA) III status were more frequently admitted following DGA. Adverse events such as emesis and hypoxia were significantly associated with patients with an unplanned admission.

Regression analysis of mixed recurrent-event and panel-count data.

PubMed

Zhu, Liang; Tong, Xinwei; Sun, Jianguo; Chen, Manhua; Srivastava, Deo Kumar; Leisenring, Wendy; Robison, Leslie L

2014-07-01

In event history studies concerning recurrent events, two types of data have been extensively discussed. One is recurrent-event data (Cook and Lawless, 2007. The Analysis of Recurrent Event Data. New York: Springer), and the other is panel-count data (Zhao and others, 2010. Nonparametric inference based on panel-count data. Test 20: , 1-42). In the former case, all study subjects are monitored continuously; thus, complete information is available for the underlying recurrent-event processes of interest. In the latter case, study subjects are monitored periodically; thus, only incomplete information is available for the processes of interest. In reality, however, a third type of data could occur in which some study subjects are monitored continuously, but others are monitored periodically. When this occurs, we have mixed recurrent-event and panel-count data. This paper discusses regression analysis of such mixed data and presents two estimation procedures for the problem. One is a maximum likelihood estimation procedure, and the other is an estimating equation procedure. The asymptotic properties of both resulting estimators of regression parameters are established. Also, the methods are applied to a set of mixed recurrent-event and panel-count data that arose from a Childhood Cancer Survivor Study and motivated this investigation. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Study of Photon Emission with the Fission Event Generator FREYA

NASA Astrophysics Data System (ADS)

Vogt, Ramona; Randrup, Jorgen

2017-09-01

The event-by-event fission model FREYA is employed to study photon observables. The model has been expanded beyond the simple statistical photon emission reported previously to include the discrete RIPL-3 lines. We update these prior results and discuss the sensitivity of the results to the FREYA input parameters sensitive to photon observables. The work of R.V. was performed under the auspices of the U.S. DOE by LLNL Contract DE-AC52-07NA27344, that of J.R. by LBNL Contract DE-AC02-05CH11231. The authors thank NNSA Defense Nuclear Nonproliferation R&D for support.

26 CFR 54.4980B-3 - Qualified beneficiaries.

Code of Federal Regulations, 2012 CFR

2012-04-01

... qualified beneficiary is— (i) Any individual who, on the day before a qualifying event, is covered under a... qualifying event that is the bankruptcy of the employer, a covered employee who had retired on or before the... bankruptcy qualifying event, the spouse, surviving spouse, or dependent child is a beneficiary under the plan...

26 CFR 54.4980B-3 - Qualified beneficiaries.

Code of Federal Regulations, 2013 CFR

2013-04-01

... qualified beneficiary is— (i) Any individual who, on the day before a qualifying event, is covered under a... qualifying event that is the bankruptcy of the employer, a covered employee who had retired on or before the... bankruptcy qualifying event, the spouse, surviving spouse, or dependent child is a beneficiary under the plan...

A study of the energy dependence of the underlying event in proton-antiproton collisions

DOE PAGES

Aaltonen, T.

2015-11-23

We study charged particle production (p T > 0.5 GeV/c, |η| < 0.8) in proton-antiproton collisions at 300 GeV, 900 GeV, and 1.96 TeV. We use the direction of the charged particle with the largest transverse momentum in each event to define three regions of η-Φspace; “toward”, “away”, and “transverse”. Furthermore, the average number and the average scalar p T sum of charged particles in the transverse region are sensitive to the modeling of the “underlying event”. The transverse region is divided into a MAX and MIN transverse region, which helps separate the “hard component” (initial and final-state radiation) frommore » the “beam-beam remnant” and multiple parton interaction components of the scattering. We found that the center-of-mass energy dependence of the various components of the event are studied in detail. The data presented here can be used to constrain and improve QCD Monte Carlo models, resulting in more precise predictions at the LHC energies of 13 and 14 TeV.« less

Visualizing Patterns of Drug Prescriptions with EventFlow: A Pilot Study of Asthma Medications in the Military Health System

DTIC Science & Technology

2013-06-01

1 Visualizing Patterns of Drug Prescriptions with EventFlow: A Pilot Study of Asthma Medications in the...asthmatics within the Military Health System (MHS). Visualizing the patterns of asthma medication use surrounding a LABA prescription is a quick way to...random sample of 100 asthma patients under age 65 with a new LABA prescription from January 1, 2006-March 1, 2010 in MHS healthcare claims. Analysis was

Stressful Life Events and Child Anxiety: Examining Parent and Child Mediators.

PubMed

Platt, Rheanna; Williams, Sarah R; Ginsburg, Golda S

2016-02-01

While a number of factors have been linked with excessive anxiety (e.g., parenting, child temperament), the impact of stressful life events remains under-studied. Moreover, much of this literature has examined bivariate associations rather than testing more complex theoretical models. The current study extends the literature on life events and child anxiety by testing a theory-driven meditational model. Specifically, one child factor (child cognitions/locus of control), two parent factors (parent psychopathology and parenting stress), and two parent-child relationship factors (parent-child dysfunctional interaction and parenting style) were examined as mediators in the relationship between stressful life events and severity of child anxiety. One hundred and thirty anxious parents and their nonanxious, high-risk children (ages ranged from 7 to 13 years) participated in this study. Results indicated that levels of parenting stress, parental anxious rearing, and dysfunctional parent-child interaction mediated the association between stressful life events and severity of anxiety symptoms. Child cognition and parent psychopathology factors failed to emerge as mediators. Findings provide support for more complex theoretical models linking life events and child anxiety and suggest potential targets of intervention.

Upsetting the apple cart: a community anticoagulation clinic survey of life event factors that undermine safe therapy.

PubMed

Edmundson, Sarah; Stuenkel, Diane L; Connolly, Phyllis M

2005-09-01

Anticoagulation therapy is a life-enhancing therapy for patients who are at risk for embolic events secondary to atrial fibrillation, valve replacement, and other comorbidities. Clinicians are motivated to decrease the amount of time that patients are either under- or over-anticoagulated, common conditions that decrease patient safety at either extreme. The primary purpose of this descriptive study was to examine the relationship between personal life event factors as measured by Norbeck's Life Events Questionnaire, core demographics such as age and income, and anticoagulation regulation. Although many factors affect anticoagulation therapy, the precise impact of life events, positive or negative, is unknown. The salient findings of this study (n = 202) showed a small, though statistically significant, inverse relationship (r = -0.184, P < .01) between negative life events and decreased time within therapeutic international normalized ratio. Total Life Event scores showed a statistically significant inverse relationship (r = -0.159, P < .05) to international normalized ratio time within therapeutic level. Lower income was inversely associated with higher negative Life Event scores (r = -0.192, P < .01). The findings demonstrate the need for strategies that address the potential impact of life events in conjunction with coexisting screening measures used in anticoagulation clinics. Implications for this study are limited by lack of methodology documenting concurrent social support factors and limitations of the research tool to reflect life event issues specific to outpatient seniors.

Internet addiction, adolescent depression, and the mediating role of life events: finding from a sample of Chinese adolescents.

PubMed

Yang, Linsheng; Sun, Liang; Zhang, Zhihua; Sun, Yehuan; Wu, Hongyan; Ye, Dongqing

2014-10-01

The aim of this study is to examine the mediating role of life events in the relation between Internet addiction and depression using an adolescent sample in China. A total of 3507 urban adolescent students were asked to complete the questionnaires including Young's Internet Addiction Scale, Adolescent Self-Rating Life Events Checklist, and Center for Epidemiologic Studies Depression Scale, Parent-Child Conflict Tactics Scales, and demographic characteristics. Path analyses demonstrated that life events fully mediated the relationship between Internet addiction and adolescent depression. Specificity for the mediating role of life events was demonstrated in comparison to alternative competing mediation models. The findings support our hypothesis that the effect of Internet addiction on adolescent depression is mediated by the life events. Further research is required to test the temporal relationship between Internet addiction and adolescent depression and explore mechanisms underlying the pathways leading to adolescent depression. © 2014 International Union of Psychological Science.

"It's a Bit like Flying": Developing Participatory Theatre with the Under-Twos--A Case Study of Oily Cart

ERIC Educational Resources Information Center

Young, Susan

2004-01-01

This article describes a case study of a new venture by the children's theatre company Oily Cart to develop a participatory theatre piece for carers and their under-two-year-olds, entitled Clouds. Given what little is known about how to design and conduct arts events with this age phase, a case study offered the opportunity to identify features…

Diagnosis of condensation-induced waterhammer: Case studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Izenson, M.G.; Rothe, P.H.; Wallis, G.B.

1988-10-01

This guidebook provides reference material and diagnostic procedures concerning condensation-induced waterhammer in nuclear power plants. Condensation-induced waterhammer is the most damaging form of waterhammer, and its diagnosis is complicated by the complex nature of the underlying phenomena. In Volume 1, the guidebook groups condensation-induced waterhammers into five event classes which have similar phenomena and levels of damage. Diagnostic guidelines focus on locating the event center where condensation and slug acceleration take place. Diagnosis is described in three stages: an initial assessment, detailed evaluation and final confirmation. Graphical scoping analyses are provided to evaluate whether an event from one of themore » event classes could have occurred at the event center. Examples are provided for each type of waterhammer. Special instructions are provided for walking down damaged piping and evaluating damage due to waterhammer. To illustrate the diagnostic methods and document past experience, six case studies have been compiled in Volume 2. These case studies, based on actual condensation-induced waterhammer events at nuclear plants, present detailed data and work through the event diagnosis using the tools introduced in the first volume. 20 refs., 21 figs., 6 tabs.« less

Sampled-data consensus in switching networks of integrators based on edge events

NASA Astrophysics Data System (ADS)

Xiao, Feng; Meng, Xiangyu; Chen, Tongwen

2015-02-01

This paper investigates the event-driven sampled-data consensus in switching networks of multiple integrators and studies both the bidirectional interaction and leader-following passive reaction topologies in a unified framework. In these topologies, each information link is modelled by an edge of the information graph and assigned a sequence of edge events, which activate the mutual data sampling and controller updates of the two linked agents. Two kinds of edge-event-detecting rules are proposed for the general asynchronous data-sampling case and the synchronous periodic event-detecting case. They are implemented in a distributed fashion, and their effectiveness in reducing communication costs and solving consensus problems under a jointly connected topology condition is shown by both theoretical analysis and simulation examples.

Efficacy, safety, and tolerance of the non-ergoline dopamine agonist pramipexole in the treatment of advanced Parkinson's disease: a double blind, placebo controlled, randomised, multicentre study.

PubMed

Pinter, M M; Pogarell, O; Oertel, W H

1999-04-01

Pramipexole, a non-ergot dopamine D2/D3 receptor agonist, was investigated as an add on drug in advanced parkinsonian patients with motor fluctuations to assess efficacy, safety, and tolerance. Seventy eight patients of either sex with advanced Parkinson's disease and treatment complications such as motor fluctuations were enrolled into a double blind, placebo controlled, randomised, multicentre study (phase II) and assigned to add on treatment with pramipexole (n=34) versus placebo (n=44) to a previously stabilised antiparkinsonian medication (7 week dose titration interval, 4 week maintenance period). The primary end point of efficacy was the change from baseline in the total score of the unified Parkinson's disease rating scale (UPDRS) in the on "period" (2 hours after intake of study medication). Safety and tolerability were assessed on the basis of adverse events, vital signs, laboratory measurements, and ECG recordings. There was a significant improvement of the pramipexole group in UPDRS total scores, subscores part II, III (activities of daily living and motor examination), and IV (complications of therapy). Mean UPDRS total score decreased by 37.3% under pramipexole compared with 12.2% under placebo (p<0.001). Patients under pramipexole reported an overall reduction in "off" periods of 12%--resulting in 1.7 more hours "on" time a day--compared with an increase in "off" periods of 2% under placebo. There were no unexpected safety results. The adverse event profile disclosed a high tolerability. The most important adverse events under pramipexole were fatigue, dyskinesia, and vivid dreams. Pramipexole administration is an efficacious and well tolerated add on therapy in patients with advanced Parkinson's disease with an improvement in activities of daily living, motor function, and treatment associated complications.

Magnetic storms and solar flares: can be analysed within similar mathematical framework with other extreme events?

NASA Astrophysics Data System (ADS)

Balasis, Georgios; Potirakis, Stelios M.; Papadimitriou, Constantinos; Zitis, Pavlos I.; Eftaxias, Konstantinos

2015-04-01

The field of study of complex systems considers that the dynamics of complex systems are founded on universal principles that may be used to describe a great variety of scientific and technological approaches of different types of natural, artificial, and social systems. We apply concepts of the nonextensive statistical physics, on time-series data of observable manifestations of the underlying complex processes ending up to different extreme events, in order to support the suggestion that a dynamical analogy characterizes the generation of a single magnetic storm, solar flare, earthquake (in terms of pre-seismic electromagnetic signals) , epileptic seizure, and economic crisis. The analysis reveals that all the above mentioned different extreme events can be analyzed within similar mathematical framework. More precisely, we show that the populations of magnitudes of fluctuations included in all the above mentioned pulse-like-type time series follow the traditional Gutenberg-Richter law as well as a nonextensive model for earthquake dynamics, with similar nonextensive q-parameter values. Moreover, based on a multidisciplinary statistical analysis we show that the extreme events are characterized by crucial common symptoms, namely: (i) high organization, high compressibility, low complexity, high information content; (ii) strong persistency; and (iii) existence of clear preferred direction of emerged activities. These symptoms clearly discriminate the appearance of the extreme events under study from the corresponding background noise.

Encoding negative events under stress: high subjective arousal is related to accurate emotional memory despite misinformation exposure.

PubMed

Hoscheidt, Siobhan M; LaBar, Kevin S; Ryan, Lee; Jacobs, W Jake; Nadel, Lynn

2014-07-01

Stress at encoding affects memory processes, typically enhancing, or preserving, memory for emotional information. These effects have interesting implications for eyewitness accounts, which in real-world contexts typically involve encoding an aversive event under stressful conditions followed by potential exposure to misinformation. The present study investigated memory for a negative event encoded under stress and subsequent misinformation endorsement. Healthy young adults participated in a between-groups design with three experimental sessions conducted 48 h apart. Session one consisted of a psychosocial stress induction (or control task) followed by incidental encoding of a negative slideshow. During session two, participants were asked questions about the slideshow, during which a random subgroup was exposed to misinformation. Memory for the slideshow was tested during the third session. Assessment of memory accuracy across stress and no-stress groups revealed that stress induced just prior to encoding led to significantly better memory for the slideshow overall. The classic misinformation effect was also observed - participants exposed to misinformation were significantly more likely to endorse false information during memory testing. In the stress group, however, memory accuracy and misinformation effects were moderated by arousal experienced during encoding of the negative event. Misinformed-stress group participants who reported that the negative slideshow elicited high arousal during encoding were less likely to endorse misinformation for the most aversive phase of the story. Furthermore, these individuals showed better memory for components of the aversive slideshow phase that had been directly misinformed. Results from the current study provide evidence that stress and high subjective arousal elicited by a negative event act concomitantly during encoding to enhance emotional memory such that the most aversive aspects of the event are well remembered and subsequently more resistant to misinformation effects. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Are precipitation-based intensity-duration-frequency curves appropriate for cost effective and resilient infrastructure design in snow-dominated regions? Next-generation curves with inclusion of rain-on-snow events

NASA Astrophysics Data System (ADS)

Yan, H.; Sun, N.; Wigmosta, M. S.; Hou, Z.

2017-12-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in the snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In this study, we examined next-generation IDF (NG-IDF) curves with inclusion of snowmelt and ROS events to improve infrastructure design in snow-dominated regions. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 377 Snowpack Telemetry (SNOTEL) stations across the western United States with at least 30 years of high quality record. We found 38% of the stations were subject to under-design, many with significant underestimation of 100-year extreme events, where the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 121% due to snowmelt and ROS events. The regions with the greatest potential for under-design were in the Pacific Northwest, the Sierra Nevada, and the Middle and Southern Rockies. We also found the potential for over-design at 27% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in development of IDF curves for engineering design procedures in snow-dominated regions.

Multi-spacecraft solar energetic particle analysis of FERMI gamma-ray flare events within the HESPERIA H2020 project

NASA Astrophysics Data System (ADS)

Tziotziou, Kostas; Malandraki, Olga; Valtonen, Eino; Heber, Bernd; Zucca, Pietro; Klein, Karl-Ludwig; Vainio, Rami; Tsiropoula, Georgia; Share, Gerald

2017-04-01

Multi-spacecraft observations of solar energetic particle (SEP) events are important for understanding the acceleration processes and the interplanetary propagation of particles released during eruptive events. In this work, we have carefully studied 25 gamma-ray flare events observed by FERMI and investigated possible associations with SEP-related events observed with STEREO and L1 spacecraft in the heliosphere. A data-driven velocity dispersion analysis (VDA) and Time-Shifting Analysis (TSA) are used for deriving the release times of protons and electrons at the Sun and for comparing them with the respective times stemming from the gamma-ray event analysis and their X-ray signatures, in an attempt to interconnect the SEPs and Fermi events and better understand the physics involved. Acknowledgements: This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 637324.

Modelling extreme climatic events in Guadalquivir Estuary ( Spain)

NASA Astrophysics Data System (ADS)

Delgado, Juan; Moreno-Navas, Juan; Pulido, Antoine; García-Lafuente, Juan; Calero Quesada, Maria C.; García, Rodrigo

2017-04-01

Extreme climatic events, such as heat waves and severe storms are predicted to increase in frequency and magnitude as a consequence of global warming but their socio-ecological effects are poorly understood, particularly in estuarine ecosystems. The Guadalquivir Estuary has been anthropologically modified several times, the original salt marshes have been transformed to grow rice and cotton and approximately one-fourth of the total surface of the estuary is now part of two protected areas, one of them is a UNESCO, MAB Biosphere Reserve. The climatic events are most likely to affect Europe in forthcoming decades and a further understanding how these climatic disturbances drive abrupt changes in the Guadalquivir estuary is needed. A barotropic model has been developed to study how severe storm events affects the estuary by conducting paired control and climate-events simulations. The changes in the local wind and atmospheric pressure conditions in the estuary have been studied in detail and several scenarios are obtained by running the model under control and real storm conditions. The model output has been validated with in situ water elevation and good agreement between modelled and real measurements have been obtained. Our preliminary results show that the model demonstrated the capability describe of the tide-surge levels in the estuary, opening the possibility to study the interaction between climatic events and the port operations and food production activities. The barotropic hydrodynamic model provide spatially explicit information on the key variables governing the tide dynamics of estuarine areas under severe climatic scenarios . The numerical model will be a powerful tool in future climate change mitigation and adaptation programs in a complex socio-ecological system.

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

PubMed

Chen, Andrew C H; Tang, Yongqiang; Rangaswamy, Madhavi; Wang, Jen C; Almasy, Laura; Foroud, Tatiana; Edenberg, Howard J; Hesselbrock, Victor; Nurnberger, John; Kuperman, Samuel; O'Connor, Sean J; Schuckit, Marc A; Bauer, Lance O; Tischfield, Jay; Rice, John P; Bierut, Laura; Goate, Alison; Porjesz, Bernice

2009-04-05

Evidence suggests the P3 amplitude of the event-related potential and its underlying superimposed event-related oscillations (EROs), primarily in the theta (4-5 Hz) and delta (1-3 Hz) frequencies, as endophenotypes for the risk of alcoholism and other disinhibitory disorders. Major neurochemical substrates contributing to theta and delta rhythms and P3 involve strong GABAergic, cholinergic and glutamatergic system interactions. The aim of this study was to test the potential associations between single nucleotide polymorphisms (SNPs) in glutamate receptor genes and ERO quantitative traits. GRM8 was selected because it maps at chromosome 7q31.3-q32.1 under the peak region where we previously identified significant linkage (peak LOD = 3.5) using a genome-wide linkage scan of the same phenotype (event-related theta band for the target visual stimuli). Neural activities recorded from scalp electrodes during a visual oddball task in which rare target elicited P3s were analyzed in a subset of the Collaborative Study on the Genetics of Alcoholism (COGA) sample comprising 1,049 Caucasian subjects from 209 families (with 472 DSM-IV alcohol dependent individuals). The family-based association test (FBAT) detected significant association (P < 0.05) with multiple SNPs in the GRM8 gene and event-related theta power to target visual stimuli, and also with alcohol dependence, even after correction for multiple comparisons by false discovery rate (FDR). Our results suggest that variation in GRM8 may be involved in modulating event-related theta oscillations during information processing and also in vulnerability to alcoholism. These findings underscore the utility of electrophysiology and the endophenotype approach in the genetic study of psychiatric disorders. (c) 2008 Wiley-Liss, Inc.

Economic Evaluations of the Health Impacts of Weather-Related Extreme Events: A Scoping Review

PubMed Central

Schmitt, Laetitia H. M.; Graham, Hilary M.; White, Piran C. L.

2016-01-01

The frequency and severity of extreme events is expected to increase under climate change. There is a need to understand the economic consequences of human exposure to these extreme events, to underpin decisions on risk reduction. We undertook a scoping review of economic evaluations of the adverse health effects from exposure to weather-related extreme events. We searched PubMed, Embase and Web of Science databases with no restrictions to the type of evaluations. Twenty studies were included, most of which were recently published. Most studies have been undertaken in the U.S. (nine studies) or Asia (seven studies), whereas we found no studies in Africa, Central and Latin America nor the Middle East. Extreme temperatures accounted for more than a third of the pool of studies (seven studies), closely followed by flooding (six studies). No economic study was found on drought. Whilst studies were heterogeneous in terms of objectives and methodology, they clearly indicate that extreme events will become a pressing public health issue with strong welfare and distributional implications. The current body of evidence, however, provides little information to support decisions on the allocation of scarce resources between risk reduction options. In particular, the review highlights a significant lack of research attention to the potential cost-effectiveness of interventions that exploit the capacity of natural ecosystems to reduce our exposure to, or ameliorate the consequences of, extreme events. PMID:27834843

Soil erosion under multiple time-varying rainfall events

NASA Astrophysics Data System (ADS)

Heng, B. C. Peter; Barry, D. Andrew; Jomaa, Seifeddine; Sander, Graham C.

2010-05-01

Soil erosion is a function of many factors and process interactions. An erosion event produces changes in surface soil properties such as texture and hydraulic conductivity. These changes in turn alter the erosion response to subsequent events. Laboratory-scale soil erosion studies have typically focused on single independent rainfall events with constant rainfall intensities. This study investigates the effect of multiple time-varying rainfall events on soil erosion using the EPFL erosion flume. The rainfall simulator comprises ten Veejet nozzles mounted on oscillating bars 3 m above a 6 m × 2 m flume. Spray from the nozzles is applied onto the soil surface in sweeps; rainfall intensity is thus controlled by varying the sweeping frequency. Freshly-prepared soil with a uniform slope was subjected to five rainfall events at daily intervals. In each 3-h event, rainfall intensity was ramped up linearly to a maximum of 60 mm/h and then stepped down to zero. Runoff samples were collected and analysed for particle size distribution (PSD) as well as total sediment concentration. We investigate whether there is a hysteretic relationship between sediment concentration and discharge within each event and how this relationship changes from event to event. Trends in the PSD of the eroded sediment are discussed and correlated with changes in sediment concentration. Close-up imagery of the soil surface following each event highlight changes in surface soil structure with time. This study enhances our understanding of erosion processes in the field, with corresponding implications for soil erosion modelling.

Effects of four-month handbike training under free-living conditions on physical fitness and health in wheelchair users.

PubMed

Hoekstra, Sven; Valent, Linda; Gobets, David; van der Woude, Lucas; de Groot, Sonja

2017-08-01

Recognizing the encouraging effect of challenging events, the HandbikeBattle (HBB) was created to promote exercise among wheelchair users. The purpose of this study was to reveal the effects on physical fitness and health outcomes of four-month handbike training under free-living conditions in preparation for the event. In this prospective cohort study, 59 relatively inexperienced handyclists participated in the HBB of 2013 or 2014. Incremental exercise tests were conducted, respiratory function was tested and anthropometrics were measured before and after the preparation period. Main outcome measures were peak power output (POpeak), peak oxygen uptake (VO2peak) and waist circumference, of which the changes were tested using repeated measures ANOVA. To detect possible determinants of changes in physical fitness, a linear regression analysis was conducted with personal characteristics, executed training volume and upper-extremity complaints during the training period as independent variables. POpeak, VO2peak and waist circumference improved significantly with 17%, 7% and 4.1%, respectively. None of the included variables were significant determinants for the changes in POpeak found as a result of the training. A challenging event such as the HBB provokes training regimes among participants of sufficient load to realize substantial improvements in physical fitness and health outcomes. Implications for Rehabilitation Due to the often impaired muscle function in the lower-limbs and an inactive lifestyle, wheelchair users generally show considerably lower levels of fitness compared to able-bodied individuals. This prospective cohort study showed that four months of handbike training under free-living conditions in preparation for this event resulted in substantial improvements in physical fitness and health outcomes in wheelchair users. The creation of a challenging event such as the HandbikeBattle as part of a follow-up rehabilitation practice can therefore be a useful tool to help wheelchair users initiate or keep training to improve their physical fitness and health.

The stressor criterion for posttraumatic stress disorder: Does it matter?

PubMed Central

Roberts, Andrea L.; Dohrenwend, Bruce P.; Aiello, Allison; Wright, Rosalind J.; Maercker, Andreas; Galea, Sandro; Koenen, Karestan C.

2013-01-01

Objective The definition of the stressor criterion for posttraumatic stress disorder (“Criterion A1”) is hotly debated with major revisions being considered for DSM-V. We examine whether symptoms, course, and consequences of PTSD vary predictably with the type of stressful event that precipitates symptoms. Method We used data from the 2009 PTSD diagnostic subsample (N=3,013) of the Nurses Health Study II. We asked respondents about exposure to stressful events qualifying under 1) DSM-III, 2) DSM-IV, or 3) not qualifying under DSM Criterion A1. Respondents selected the event they considered worst and reported subsequent PTSD symptoms. Among participants who met all other DSM-IV PTSD criteria, we compared distress, symptom severity, duration, impairment, receipt of professional help, and nine physical, behavioral, and psychiatric sequelae (e.g. physical functioning, unemployment, depression) by precipitating event group. Various assessment tools were used to determine fulfillment of PTSD Criteria B through F and to assess these 14 outcomes. Results Participants with PTSD from DSM-III events reported on average 1 more symptom (DSM-III mean=11.8 symptoms, DSM-IV=10.7, non-DSM=10.9) and more often reported symptoms lasted one year or longer compared to participants with PTSD from other groups. However, sequelae of PTSD did not vary systematically with precipitating event type. Conclusions Results indicate the stressor criterion as defined by the DSM may not be informative in characterizing PTSD symptoms and sequelae. In the context of ongoing DSM-V revision, these results suggest that Criterion A1 could be expanded in DSM-V without much consequence for our understanding of PTSD phenomenology. Events not considered qualifying stressors under the DSM produced PTSD as consequential as PTSD following DSM-III events, suggesting PTSD may be an aberrantly severe but nonspecific stress response syndrome. PMID:22401487

Coding of adverse events of suicidality in clinical study reports of duloxetine for the treatment of major depressive disorder: descriptive study

PubMed Central

Tendal, Britta; Hróbjartsson, Asbjørn; Lundh, Andreas; Gøtzsche, Peter C

2014-01-01

Objective To assess the effects of coding and coding conventions on summaries and tabulations of adverse events data on suicidality within clinical study reports. Design Systematic electronic search for adverse events of suicidality in tables, narratives, and listings of adverse events in individual patients within clinical study reports. Where possible, for each event we extracted the original term reported by the investigator, the term as coded by the medical coding dictionary, medical coding dictionary used, and the patient’s trial identification number. Using the patient’s trial identification number, we attempted to reconcile data on the same event between the different formats for presenting data on adverse events within the clinical study report. Setting 9 randomised placebo controlled trials of duloxetine for major depressive disorder submitted to the European Medicines Agency for marketing approval. Data sources Clinical study reports obtained from the EMA in 2011. Results Six trials used the medical coding dictionary COSTART (Coding Symbols for a Thesaurus of Adverse Reaction Terms) and three used MedDRA (Medical Dictionary for Regulatory Activities). Suicides were clearly identifiable in all formats of adverse event data in clinical study reports. Suicide attempts presented in tables included both definitive and provisional diagnoses. Suicidal ideation and preparatory behaviour were obscured in some tables owing to the lack of specificity of the medical coding dictionary, especially COSTART. Furthermore, we found one event of suicidal ideation described in narrative text that was absent from tables and adverse event listings of individual patients. The reason for this is unclear, but may be due to the coding conventions used. Conclusion Data on adverse events in tables in clinical study reports may not accurately represent the underlying patient data because of the medical dictionaries and coding conventions used. In clinical study reports, the listings of adverse events for individual patients and narratives of adverse events can provide additional information, including original investigator reported adverse event terms, which can enable a more accurate estimate of harms. PMID:24899651

An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imaging.

PubMed

Ellefsen, Kyle L; Settle, Brett; Parker, Ian; Smith, Ian F

2014-09-01

Local Ca(2+) transients such as puffs and sparks form the building blocks of cellular Ca(2+) signaling in numerous cell types. They have traditionally been studied by linescan confocal microscopy, but advances in TIRF microscopy together with improved electron-multiplied CCD (EMCCD) cameras now enable rapid (>500 frames s(-1)) imaging of subcellular Ca(2+) signals with high spatial resolution in two dimensions. This approach yields vastly more information (ca. 1 Gb min(-1)) than linescan imaging, rendering visual identification and analysis of local events imaged both laborious and subject to user bias. Here we describe a routine to rapidly automate identification and analysis of local Ca(2+) events. This features an intuitive graphical user-interfaces and runs under Matlab and the open-source Python software. The underlying algorithm features spatial and temporal noise filtering to reliably detect even small events in the presence of noisy and fluctuating baselines; localizes sites of Ca(2+) release with sub-pixel resolution; facilitates user review and editing of data; and outputs time-sequences of fluorescence ratio signals for identified event sites along with Excel-compatible tables listing amplitudes and kinetics of events. Copyright © 2014 Elsevier Ltd. All rights reserved.

Impaired theta phase-resetting underlying auditory N1 suppression in chronic alcoholism.

PubMed

Fuentemilla, Lluis; Marco-Pallarés, Josep; Gual, Antoni; Escera, Carles; Polo, Maria Dolores; Grau, Carles

2009-02-18

It has been suggested that chronic alcoholism may lead to altered neural mechanisms related to inhibitory processes. Here, we studied auditory N1 suppression phenomena (i.e. amplitude reduction with repetitive stimuli) in chronic alcoholic patients as an early-stage information-processing brain function involving inhibition by the analysis of the N1 event-related potential and time-frequency computation (spectral power and phase-resetting). Our results showed enhanced neural theta oscillatory phase-resetting underlying N1 generation in suppressed N1 event-related potential. The present findings suggest that chronic alcoholism alters neural oscillatory synchrony dynamics at very early stages of information processing.

Twenty-Four-Hour Central Pulse Pressure for Cardiovascular Events Prediction in a Low-Cardiovascular-Risk Population: Results From the Bordeaux Cohort.

PubMed

Cremer, Antoine; Boulestreau, Romain; Gaillard, Prune; Lainé, Marion; Papaioannou, Georgios; Gosse, Philippe

2018-02-23

Central blood pressure (BP) is a promising marker to identify subjects with higher cardiovascular risk than expected by traditional risk factors. Significant results have been obtained in populations with high cardiovascular risk, but little is known about low-cardiovascular-risk patients, although the differences between central and peripheral BP (amplification) are usually greater in this population. The study aim was to evaluate central BP over 24 hours for cardiovascular event prediction in hypertensive subjects with low cardiovascular risk. Peripheral and central BPs were recorded during clinical visits and over 24 hours in hypertensive patients with low cardiovascular risk (Systematic Coronary Risk Evaluation ≤5%). Our primary end point is the occurrence of a cardiovascular event during follow-up. To assess the potential interest in central pulse pressure over 24 hours, we performed Cox proportional hazard models analysis and comparison of area under the curves using the contrast test for peripheral and central BP. A cohort of 703 hypertensive subjects from Bordeaux were included. After the first 24 hours of BP measurement, the subjects were then followed up for an average of 112.5±70 months. We recorded 65 cardiovascular events during follow-up. Amplification was found to be significantly associated with cardiovascular events when added to peripheral 24-hour pulse pressure ( P =0.0259). The area under the curve of 24-hour central pulse pressure is significantly more important than area under the curve of office BP ( P =0.0296), and there is a trend of superiority with the area under the curve of peripheral 24-hour pulse pressure. Central pulse pressure over 24 hours improves the prediction of cardiovascular events for hypertensive patients with low cardiovascular risk compared to peripheral pulse pressure. © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

A Climatology of Nocturnal-Convection Initiation Over the Central Great Plains

NASA Astrophysics Data System (ADS)

Reif, D. W.; Bluestein, H. B.

2015-12-01

A nocturnal maximum in rainfall and thunderstorm activity over the central Great Plains is widely documented, but the mechanisms for understanding the development of thunderstorms over the region at night are still not well understood. Elevated convection, defined by Colman (1990) as storms formed through ascent above frontal surfaces, is one explanation, but our study shows that many thunderstorms can initiate at night without the presence of an elevated frontal inversion or nearby surface boundary. We address the following questions: Of all the events documented, what percentage fall under this definition of elevated convection, and what percentage fall outside of that definition? How do characteristics differ among the events that fall under that definition and the events that fall outside that definition? This study documents convection initiation (CI) events occurring at night over the central Great Plains from 1996 through 2014 during the months of April through July. Storm characteristics such as storm type (defined as linear, areal, or single cell), storm motion, initiation time and location, and others were documented. Once all of the cases were documented, surface data were examined to locate any nearby surface boundaries. The event's location relative to these boundaries (if they existed) was documented. Three main modes of CI were identified: formation on a surface boundary, formation on the cold side of a surface boundary, and formation without the presence of a surface boundary. A climatology of these events will be presented. There are many differences among the different modes of CI at night. One result is that there appears to be two main peaks of CI time at night: one early at night and one later at night. The later peak is likely due to the events that form in the absence of a nearby surface boundary.

Citizen sensors for SHM: use of accelerometer data from smartphones.

PubMed

Feng, Maria; Fukuda, Yoshio; Mizuta, Masato; Ozer, Ekin

2015-01-29

Ubiquitous smartphones have created a significant opportunity to form a low-cost wireless Citizen Sensor network and produce big data for monitoring structural integrity and safety under operational and extreme loads. Such data are particularly useful for rapid assessment of structural damage in a large urban setting after a major event such as an earthquake. This study explores the utilization of smartphone accelerometers for measuring structural vibration, from which structural health and post-event damage can be diagnosed. Widely available smartphones are tested under sinusoidal wave excitations with frequencies in the range relevant to civil engineering structures. Large-scale seismic shaking table tests, observing input ground motion and response of a structural model, are carried out to evaluate the accuracy of smartphone accelerometers under operational, white-noise and earthquake excitations of different intensity. Finally, the smartphone accelerometers are tested on a dynamically loaded bridge. The extensive experiments show satisfactory agreements between the reference and smartphone sensor measurements in both time and frequency domains, demonstrating the capability of the smartphone sensors to measure structural responses ranging from low-amplitude ambient vibration to high-amplitude seismic response. Encouraged by the results of this study, the authors are developing a citizen-engaging and data-analytics crowdsourcing platform towards a smartphone-based Citizen Sensor network for structural health monitoring and post-event damage assessment applications.

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2014 CFR

2014-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

29 CFR 4043.27 - Distribution to a substantial owner.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.27 Distribution to a substantial owner. (a) Reportable event. A reportable event occurs for... does not exceed the limitation (as of the date the reportable event occurs) under section 415(b)(1)(A...

Applications of computer-graphics animation for motion-perception research

NASA Technical Reports Server (NTRS)

Proffitt, D. R.; Kaiser, M. K.

1986-01-01

The advantages and limitations of using computer animated stimuli in studying motion perception are presented and discussed. Most current programs of motion perception research could not be pursued without the use of computer graphics animation. Computer generated displays afford latitudes of freedom and control that are almost impossible to attain through conventional methods. There are, however, limitations to this presentational medium. At present, computer generated displays present simplified approximations of the dynamics in natural events. Very little is known about how the differences between natural events and computer simulations influence perceptual processing. In practice, the differences are assumed to be irrelevant to the questions under study, and that findings with computer generated stimuli will generalize to natural events.

On extreme events for non-spatial and spatial branching Brownian motions

NASA Astrophysics Data System (ADS)

Avan, Jean; Grosjean, Nicolas; Huillet, Thierry

2015-04-01

We study the impact of having a non-spatial branching mechanism with infinite variance on some parameters (height, width and first hitting time) of an underlying Bienaymé-Galton-Watson branching process. Aiming at providing a comparative study of the spread of an epidemics whose dynamics is given by the modulus of a branching Brownian motion (BBM) we then consider spatial branching processes in dimension d, not necessarily integer. The underlying branching mechanism is either a binary branching model or one presenting infinite variance. In particular we evaluate the chance p(x) of being hit if the epidemics started away at distance x. We compute the large x tail probabilities of this event, both when the branching mechanism is regular and when it exhibits very large fluctuations.

The ancestral selection graph under strong directional selection.

PubMed

Pokalyuk, Cornelia; Pfaffelhuber, Peter

2013-08-01

The ancestral selection graph (ASG) was introduced by  Neuhauser and Krone (1997) in order to study populations of constant size which evolve under selection. Coalescence events, which occur at rate 1 for every pair of lines, lead to joint ancestry. In addition, splitting events in the ASG at rate α, the scaled selection coefficient, produce possible ancestors, such that the real ancestor depends on the ancestral alleles. Here, we use the ASG in the case without mutation in order to study fixation of a beneficial mutant. Using our main tool, a reversibility property of the ASG, we provide a new proof of the fact that a beneficial allele fixes roughly in time (2logα)/α if α is large. Copyright © 2012 Elsevier Inc. All rights reserved.

Impact Assessments and Projections in Microclimates: Working with End-Users

NASA Astrophysics Data System (ADS)

Outten, S.; Wolf, T.

2015-12-01

Local impacts of meteorological events are often shaped by the microclimates in which they occur and only by including understanding of these microclimates can robust assessments and projections of such events be made. However, co-production of knowledge with end users is also required in order to make the assessments useful for decision makers and for society as a whole. This work presents two studies working with end users around the European city of Bergen, Norway. The first study is on extreme winds assessment for larger-scale construction. While such an assessment is usually based on historical observations when the climate was more stationary, under a changing climate, infrastructure built to last for the next fifty years or more may experience events not seen in the observational period. The case study is presented for the newly completed Hardanger Bridge in Norway and demonstrates a novel method for incorporating estimates of future changes in extreme winds into the design process (figure 1). Given the close collaboration with the engineers involved in the bridge's construction, the method was tailored to fit with existing practices and standards. The second study focuses on air pollution events within the city that are favoured by persistent wintertime temperature inversions in the narrow Bergen valley. Using a temperature profile radiometer, these temperature inversions have been characterized and related to the local circulation in- and above the valley. There has been the assumption that the many large ships in Bergen harbour had a major contribution to high pollution events within the city. Results from this study however indicate that temperature inversions are mostly connected to down-valley winds. These should remove the ship-emissions from the city, giving the ships a much smaller impact on high air pollution events than previously assumed, something that is under further evaluation and of high interest for the local harbour authority. Figure 1. Extreme wind speed distributions at the Utsira meteorological station from observations (black), with future estimates based on multiple regional climate models (red and blue). Vertical lines indicate the 50-year return event.

On the characteristics of emulsion chamber family events produced in low heights

NASA Technical Reports Server (NTRS)

Jing, G.; Jing, C.; Zhu, Q.; Ding, L.

1985-01-01

The uncertainty of the primary cosmic ray composition at 10 to the 14th power -10 to the 16th power eV is well known to make the study of the nuclear interaction mechanism more difficult. Experimentally considering, if one can identify effectively the family events which are produced in low heights, then an event sample induced by primary protons might be able to be separated. It is undoubtedly very meaningful. In this paper an attempt is made to simulate the family events under the condition of mountain emulsion chamber experiments with a reasonable model. The aim is to search for the dependence of some experimentally observable quantities to the interaction height.

Study of the combinatorial impact of empathy and emotion on the processing of conflicts of interest with the event-related potential technique.

PubMed

He, Xiaoli; Zhang, Ni

2017-01-01

Studies have found that empathy is important in moral development and violence suppression, and emotion also affects empathy. However, the combinatorial effect of emotion and empathy on the processing of conflicts is not known. A total of 44 undergraduate students (23 in low-empathy group and 21 in high-empathy group) were enrolled in this study. They were subjected to positive, negative, and neutral emotion evoking, as well as conflicting or nonconflicting proposals. Event-related potential technology was used to study the combinatorial effects of empathy and emotion on the processing of conflict of interest. We found that under the influence of a positive emotion, both low- and high-empathy groups exhibited lower rejection rates. In the context of conflict, individuals in the high-empathy group showed fewer refusals under positive emotion. In the low-empathy group, there was no significant difference between responses to different emotions, but conflicting proposals induced more negative medial frontal negativity than nonconflicting proposals. Individuals in the low-empathy group showed different late positive potentials when responding to different types of proposals under both neutral and negative emotions, whereas those in the high-empathy group only showed different late positive potentials responding to different types of proposals under negative emotion. Our results indicate that under positive emotion, individuals with low empathy show less difference in processing either conflicting or nonconflicting proposals, whereas under negative emotion, individuals with high empathy show enhanced motivation toward nonconflicting proposals.

Extreme events of perceived temperature over Europe: a projected northward extension of dangerous areas

NASA Astrophysics Data System (ADS)

Scoccimarro, Enrico; Fogli, Pier Giuseppe; Gualdi, Silvio

2017-04-01

It is well known that an increase of temperature over Europe, both in terms of averages and extremes, is expected within the current century. In order to consider health impacts under warm conditions, it is important to take into account the combined effect of temperature and humidity on the human body. To this aim a basic index - the humindex - representative of the perceived temperature, under different scenarios and periods, has been investigated in this study. A very low concomitance of extreme temperature events and extreme humindex events is found over the present climate, reinforcing the importance to investigate not only extreme temperature and relative humidity future projections but also the combination of the two parameters. A set of 10-km resolution regional climate simulations provided within the EUR-11 EURO-CORDEX multi-model effort, demonstrates ability in representing the intense and extreme events of the humindex over the present climate and to be eligible as a tool to quantify future changes in geographical patterns of exposed areas over Europe. An enlargement of the domain subject to dangerous conditions is found since the middle of the current century, reaching 60 degrees North when considering really extreme events. The most significant increase in humindex extreme events is found when comparing the 2066-2095 projections under rcp8.5 scenario, to the 1966-2005 period: bearing in mind that changes in relative humidity may either amplify or offset the health effects of temperature extremes, a less pronounced projected reduction of relative humidity intensity in the Northern part of the European domain, associated to extreme temperature and humindex, makes Northern Europe the most prone region to a local increase of the humindex extremes.

Flood events across the North Atlantic region - past development and future perspectives

NASA Astrophysics Data System (ADS)

Matti, Bettina; Dieppois, Bastien; Lawler, Damian; Dahlke, Helen E.; Lyon, Steve W.

2016-04-01

Flood events have a large impact on humans, both socially and economically. An increase in winter and spring flooding across much of northern Europe in recent years opened up the question of changing underlying hydro-climatic drivers of flood events. Predicting the manifestation of such changes is difficult due to the natural variability and fluctuations in northern hydrological systems caused by large-scale atmospheric circulations, especially under altered climate conditions. Improving knowledge on the complexity of these hydrological systems and their interactions with climate is essential to be able to determine drivers of flood events and to predict changes in these drivers under altered climate conditions. This is particularly true for the North Atlantic region where both physical catchment properties and large-scale atmospheric circulations have a profound influence on floods. This study explores changes in streamflow across North Atlantic region catchments. An emphasis is placed on high-flow events, namely the timing and magnitude of past flood events, and selected flood percentiles were tested for stationarity by applying a flood frequency analysis. The issue of non-stationarity of flood return periods is important when linking streamflow to large-scale atmospheric circulations. Natural fluctuations in these circulations are found to have a strong influence on the outcome causing natural variability in streamflow records. Long time series and a multi-temporal approach allows for determining drivers of floods and linking streamflow to large-scale atmospheric circulations. Exploring changes in selected hydrological signatures consistency was found across much of the North Atlantic region suggesting a shift in flow regime. The lack of an overall regional pattern suggests that how catchments respond to changes in climatic drivers is strongly influenced by their physical characteristics. A better understanding of hydrological response to climate drivers is essential for example for forecasting purposes.

What the stories children tell can tell about their memory: narrative skill and young children's suggestibility.

PubMed

Kulkofsky, Sarah; Klemfuss, J Zoe

2008-09-01

The authors examined the relation between children's narrative ability, which has been identified as an important contributor to memory development, and suggestibility. Across 2 studies, a total of 112 preschool-aged children witnessed a staged event and were subsequently questioned suggestively. Results from Study 1 indicated that children's ability to provide a high-quality narrative of the event was related to resistance to suggestive questions, and narrative ability appeared to supersede age as a predictor of such resistance. In Study 2, children's general language and narrative abilities were measured in addition to their ability to produce a high-quality narrative about the target event. These results replicated Study 1's findings that children's ability to produce a high-quality narrative of a previously experienced event predicted resistance to suggestion. However, the quality of children's autobiographical memory narratives predicted shifting from denial to assent. Findings are considered in light of narrative's role in memory development and underlying mechanisms that may explain children's suggestibility.

More frequent showers and thunderstorm days under a warming climate: evidence observed over Northern Eurasia from 1966 to 2000

NASA Astrophysics Data System (ADS)

Ye, Hengchun; Fetzer, Eric J.; Wong, Sun; Lambrigtsen, Bjorn H.; Wang, Tao; Chen, Luke; Dang, Van

2017-09-01

This study uses 3-hourly synoptic observations at 547 stations to examine changes in convective and non-convective precipitation days and their associations with surface air temperature and specific humidity over Northern Eurasia. We found that convective days (showers and those associated with thunder and lightning) have become more frequent possibly at the expense of non-convective ones for all seasons during the study period of 1966-2000. The mean trends for convective day fraction (total convective precipitation events divided by all precipitation events for each season) are very similar among all four seasons at around 0.61-0.76% per year averaged over the study region. The temperature and humidity associated with convective events are on average 2.4-5.6 °C and 0.4-0.9 g/kg higher than those of non-convective events, respectively. This study suggests that surface warming and moistening lead to increased tropospheric static instability, contributing to the observed trends.

Extremely cold events and sudden air temperature drops during winter season in the Czech Republic

NASA Astrophysics Data System (ADS)

Crhová, Lenka; Valeriánová, Anna; Holtanová, Eva; Müller, Miloslav; Kašpar, Marek; Stříž, Martin

2014-05-01

Today a great attention is turned to analysis of extreme weather events and frequency of their occurrence under changing climate. In most cases, these studies are focused on extremely warm events in summer season. However, extremely low values of air temperature during winter can have serious impacts on many sectors as well (e.g. power engineering, transportation, industry, agriculture, human health). Therefore, in present contribution we focus on extremely and abnormally cold air temperature events in winter season in the Czech Republic. Besides the seasonal extremes of minimum air temperature determined from station data, the standardized data with removed annual cycle are used as well. Distribution of extremely cold events over the season and the temporal evolution of frequency of occurrence during the period 1961-2010 are analyzed. Furthermore, the connection of cold events with extreme sudden temperature drops is studied. The extreme air temperature events and events of extreme sudden temperature drop are assessed using the Weather Extremity Index, which evaluates the extremity (based on return periods) and spatial extent of the meteorological extreme event of interest. The generalized extreme value distribution parameters are used to estimate return periods of daily temperature values. The work has been supported by the grant P209/11/1990 funded by the Czech Science Foundation.

The Cognitive Processes Underlying Event-Based Prospective Memory in School-Age Children and Young Adults: A Formal Model-Based Study

ERIC Educational Resources Information Center

Smith, Rebekah E.; Bayen, Ute J.; Martin, Claudia

2010-01-01

Fifty children 7 years of age (29 girls, 21 boys), 53 children 10 years of age (29 girls, 24 boys), and 36 young adults (19 women, 17 men) performed a computerized event-based prospective memory task. All 3 groups differed significantly in prospective memory performance, with adults showing the best performance and with 7-year-olds showing the…

A Probabilistic Analysis of Surface Water Flood Risk in London.

PubMed

Jenkins, Katie; Hall, Jim; Glenis, Vassilis; Kilsby, Chris

2018-06-01

Flooding in urban areas during heavy rainfall, often characterized by short duration and high-intensity events, is known as "surface water flooding." Analyzing surface water flood risk is complex as it requires understanding of biophysical and human factors, such as the localized scale and nature of heavy precipitation events, characteristics of the urban area affected (including detailed topography and drainage networks), and the spatial distribution of economic and social vulnerability. Climate change is recognized as having the potential to enhance the intensity and frequency of heavy rainfall events. This study develops a methodology to link high spatial resolution probabilistic projections of hourly precipitation with detailed surface water flood depth maps and characterization of urban vulnerability to estimate surface water flood risk. It incorporates probabilistic information on the range of uncertainties in future precipitation in a changing climate. The method is applied to a case study of Greater London and highlights that both the frequency and spatial extent of surface water flood events are set to increase under future climate change. The expected annual damage from surface water flooding is estimated to be to be £171 million, £343 million, and £390 million/year under the baseline, 2030 high, and 2050 high climate change scenarios, respectively. © 2017 Society for Risk Analysis.

Importance of ABA homeostasis under terminal drought stress in regulating grain filling events

PubMed Central

Govind, Geetha; Seiler, Christiane; Wobus, Ulrich

2011-01-01

Recent studies suggest that abscisic acid (ABA) at its basal level plays an important role during seed set and grain filling events. Under drought stress ABA levels were found to be significantly enhanced in the developing seed. Until now we lacked an understanding of (1) ABA homeostasis in developing seeds under terminal drought and (2) the interactive role of ABA in regulating the starch biosynthesis pathway in developing grains under terminal drought. We have recently reported the possible regulation of ABA homeostasis in source (flag leaf) and sink (developing grains) tissues under post-anthesis drought stress in barley and concluded that significantly enhanced ABA levels in developing grains are due to strong activation of the ABA deconjugation pathway and fine regulation of the ABA biosynthesis-degradation pathway.1 Additionally, we provided evidence for the role of ABA in differential regulation of starch biosynthesis genes and a significant upregulation of starch degradation beta amylase genes under drought, i.e., ABA not only influences the rate of starch accumulation but also starch quality. PMID:21778825

A model of spreading of sudden events on social networks

NASA Astrophysics Data System (ADS)

Wu, Jiao; Zheng, Muhua; Zhang, Zi-Ke; Wang, Wei; Gu, Changgui; Liu, Zonghua

2018-03-01

Information spreading has been studied for decades, but its underlying mechanism is still under debate, especially for those ones spreading extremely fast through the Internet. By focusing on the information spreading data of six typical events on Sina Weibo, we surprisingly find that the spreading of modern information shows some new features, i.e., either extremely fast or slow, depending on the individual events. To understand its mechanism, we present a susceptible-accepted-recovered model with both information sensitivity and social reinforcement. Numerical simulations show that the model can reproduce the main spreading patterns of the six typical events. By this model, we further reveal that the spreading can be speeded up by increasing either the strength of information sensitivity or social reinforcement. Depending on the transmission probability and information sensitivity, the final accepted size can change from continuous to discontinuous transition when the strength of the social reinforcement is large. Moreover, an edge-based compartmental theory is presented to explain the numerical results. These findings may be of significance on the control of information spreading in modern society.

Playa Soil Moisture and Evaporation Dynamics During the MATERHORN Field Program

NASA Astrophysics Data System (ADS)

Hang, Chaoxun; Nadeau, Daniel F.; Jensen, Derek D.; Hoch, Sebastian W.; Pardyjak, Eric R.

2016-06-01

We present an analysis of field data collected over a desert playa in western Utah, USA in May 2013, the most synoptically active month of the year, as part of the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) program. The results show that decreasing surface albedo, decreasing Bowen ratio and increasing net radiation with increasing soil moisture sustained a powerful positive feedback mechanism promoting large evaporation rates immediately following rain events. Additionally, it was found that, while nocturnal evaporation was negligible during dry periods, it was quite significant (up to 30 % of the daily cumulative flux) during nights following rain events. Our results further show that the highest spatial variability in surface soil moisture is found under dry conditions. Finally, we report strong spatial heterogeneities in evaporation rates following a rain event. The cumulative evaporation for the different sampling sites over a five-day period varied from ≈ 0.1 to ≈ 6.6 mm. Overall, this study allows us to better understand the mechanisms underlying soil moisture dynamics of desert playas as well as evaporation following occasional rain events.

Stressful Life Events and Child Anxiety: Examining Parent and Child Mediators

PubMed Central

Platt, Rheanna; Williams, Sarah R.; Ginsburg, Golda S.

2015-01-01

While a number of factors have been linked with excessive anxiety (e.g., parenting, child temperament), the impact of stressful life events remains under-studied. Moreover, much of this literature has examined bivariate associations rather than testing more complex theoretical models. The current study extends the literature on life events and child anxiety by testing a theory-driven meditational model. Specifically, one child factor (child cognitions/locus of control), two parent factors (parent psychopathology and parenting stress), and two parent-child relationship factors (parent-child dysfunctional interaction and parenting style) were examined as mediators in the relationship between stressful life events and severity of child anxiety. One hundred and thirty anxious parents and their nonanxious, high-risk children (ages ranged from 7 to 13 years) participated in this study. Results indicated that levels of parenting stress, parental anxious rearing, and dysfunctional parent-child interaction mediated the association between stressful life events and severity of anxiety symptoms. Child cognition and parent psychopathology factors failed to emerge as mediators. Findings provide support for more complex theoretical models linking life events and child anxiety and suggest potential targets of intervention. PMID:25772523

[Adverse events of anesthesia in pediatric surgery scheduled at Gabriel Toure hospital].

PubMed

Samaké, B; Keita, M; Magalie, I M C; Diallo, G; Diallo, A

2010-01-01

The occurrence of an event planned or unplanned during anesthesia is a concern for staff. This event may jeopardize the success of surgery gesture. Pediatric Surgery therefore has its own specific complications that it requires anesthesia. To evaluate the incidence of adverse events during anesthesia in pediatric surgery scheduled. Descriptive non-randomized study. Descriptive non-randomized study on adverse events related to anesthesia in children over a period of seven months. It took place in the anesthesia and intensive care unit and the pediatric surgery unit of Gabriel Toure hospital in Bamako. It focused on patients aged 0 to 12 years scheduled for surgery under general anesthesia during the study period. Sixty six percent of patients selected was male gender with a sex ratio of 3 in favor of males. The average age was 2 years with extremes of 16 days and 12 years and a standard deviation of 2.93. The old history of premature was found in 36% of patients and 2% of asthmatic. The number of patients experiencing an adverse event is 42 on a total of 107 patients collected either 39.25%. When the children were younger than one year adverse events occurred with 30, 76%. The occurrence of adverse events was more frequent when the child was not intubated with P < 0.05. All adverse events have received support except tachycardia, late revival but all developed positively. This study estimates the incidence of adverse events in anesthesia during pediatric surgery. The overall rate of patients experiencing an adverse event is relatively high. Children age less than or equal to one year are most vulnerable.

Measurement of distributions sensitive to the underlying event in inclusive Z-boson production in [Formula: see text] collisions at [Formula: see text] TeV with the ATLAS detector.

PubMed

Aad, G; Abbott, B; Abdallah, J; Abdel Khalek, S; Abdinov, O; Aben, R; Abi, B; Abolins, M; AbouZeid, O S; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, B S; Adamczyk, L; Adams, D L; Adelman, J; Adomeit, S; Adye, T; Agatonovic-Jovin, T; Aguilar-Saavedra, J A; Agustoni, M; Ahlen, S P; Ahmadov, F; Aielli, G; Akerstedt, H; Åkesson, T P A; Akimoto, G; Akimov, A V; Alberghi, G L; Albert, J; Albrand, S; Alconada Verzini, M J; Aleksa, M; Aleksandrov, I N; Alexa, C; Alexander, G; Alexandre, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Allbrooke, B M M; Allison, L J; Allport, P P; Almond, J; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Alvarez Gonzalez, B; Alviggi, M G; Amako, K; Amaral Coutinho, Y; Amelung, C; Amidei, D; Amor Dos Santos, S P; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, L S; Andari, N; Andeen, T; Anders, C F; Anders, G; Anderson, K J; Andreazza, A; Andrei, V; Anduaga, X S; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, A V; Anjos, N; Annovi, A; Antonaki, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Aperio Bella, L; Apolle, R; Arabidze, G; Aracena, I; Arai, Y; Araque, J P; Arce, A T H; Arguin, J-F; Argyropoulos, S; Arik, M; Armbruster, A J; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Åsman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, N B; Auerbach, B; Augsten, K; Aurousseau, M; Avolio, G; Azuelos, G; Azuma, Y; Baak, M A; Baas, A; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Backus Mayes, J; Badescu, E; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, J T; Baker, O K; Balek, P; Balli, F; Banas, E; Banerjee, Sw; Bannoura, A A E; Bansal, V; Bansil, H S; Barak, L; Baranov, S P; Barberio, E L; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnett, B M; Barnett, R M; Barnovska, Z; Baroncelli, A; Barone, G; Barr, A J; Barreiro, F; Barreiro Guimarães da Costa, J; Bartoldus, R; Barton, A E; Bartos, P; Bartsch, V; Bassalat, A; Basye, A; Bates, R L; Batley, J R; Battaglia, M; Battistin, M; Bauer, F; Bawa, H S; Beattie, M D; Beau, T; Beauchemin, P H; Beccherle, R; Bechtle, P; Beck, H P; Becker, K; Becker, S; Beckingham, M; Becot, C; Beddall, A J; Beddall, A; Bedikian, S; Bednyakov, V A; Bee, C P; Beemster, L J; Beermann, T A; Begel, M; Behr, K; Belanger-Champagne, C; Bell, P J; Bell, W H; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bendtz, K; Benekos, N; Benhammou, Y; Benhar Noccioli, E; Benitez Garcia, J A; Benjamin, D P; Bensinger, J R; Benslama, K; Bentvelsen, S; Berge, D; Bergeaas Kuutmann, E; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernat, P; Bernius, C; Bernlochner, F U; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, M I; Besjes, G J; Bessidskaia, O; Bessner, M; Besson, N; Betancourt, C; Bethke, S; 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Yorita, K; Yoshida, R; Yoshihara, K; Young, C; Young, C J S; Youssef, S; Yu, D R; Yu, J; Yu, J M; Yu, J; Yuan, L; Yurkewicz, A; Yusuff, I; Zabinski, B; Zaidan, R; Zaitsev, A M; Zaman, A; Zambito, S; Zanello, L; Zanzi, D; Zeitnitz, C; Zeman, M; Zemla, A; Zengel, K; Zenin, O; Ženiš, T; Zerwas, D; Zevi Della Porta, G; Zhang, D; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, X; Zhang, Z; Zhao, Z; Zhemchugov, A; Zhong, J; Zhou, B; Zhou, L; Zhou, N; Zhu, C G; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zibell, A; Zieminska, D; Zimine, N I; Zimmermann, C; Zimmermann, R; Zimmermann, S; Zimmermann, S; Zinonos, Z; Ziolkowski, M; Zobernig, G; Zoccoli, A; Zur Nedden, M; Zurzolo, G; Zutshi, V; Zwalinski, L

A measurement of charged-particle distributions sensitive to the properties of the underlying event is presented for an inclusive sample of events containing a [Formula: see text]-boson, decaying to an electron or muon pair. The measurement is based on data collected using the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of [Formula: see text] TeV with an integrated luminosity of [Formula: see text] fb[Formula: see text]. Distributions of the charged particle multiplicity and of the charged particle transverse momentum are measured in regions of azimuthal angle defined with respect to the [Formula: see text]-boson direction. The measured distributions are compared to similar distributions measured in jet events, and to the predictions of various Monte Carlo generators implementing different underlying event models.

Measurement of the underlying event activity in inclusive Z boson production in proton-proton collisions at $$\\sqrt{s} = $$ 13 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirunyan, Albert M; et al.

This paper presents a measurement of the underlying event activity in proton-proton collisions at a center-of-mass energy of 13 TeV, performed using inclusive Z boson production events collected with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 2.1 fbmore » $$^{-1}$$. The underlying event activity is quantified in terms of the charged particle multiplicity, as well as of the scalar sum of the charged particles' transverse momenta in different topological regions defined with respect to the Z boson direction. The distributions are unfolded to the stable particle level and compared with predictions from various Monte Carlo event generators, as well as with similar CDF and CMS measurements at center-of-mass energies of 1.96 and 7 TeV respectively.« less

Measurement of distributions sensitive to the underlying event in inclusive Z-boson production in pp collisions at √s = 7 TeV with the ATLAS detector

DOE PAGES

Aad, G.

2014-12-10

A measurement of charged-particle distributions sensitive to the properties of the underlying event is presented for an inclusive sample of events containing a \\(Z\\)-boson, decaying to an electron or muon pair. The measurement is based on data collected using the ATLAS detector at the LHC in proton–proton collisions at a centre-of-mass energy of \\(7\\) TeV with an integrated luminosity of \\(4.6\\) fb\\(^{-1}\\). Distributions of the charged particle multiplicity and of the charged particle transverse momentum are measured in regions of azimuthal angle defined with respect to the \\(Z\\)-boson direction. As a result, the measured distributions are compared to similar distributionsmore » measured in jet events, and to the predictions of various Monte Carlo generators implementing different underlying event models.« less

Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma.

PubMed

Yamamoto, Yoshiaki; Tsunedomi, Ryouichi; Fujita, Yusuke; Otori, Toru; Ohba, Mitsuyoshi; Kawai, Yoshihisa; Hirata, Hiroshi; Matsumoto, Hiroaki; Haginaka, Jun; Suzuki, Shigeo; Dahiya, Rajvir; Hamamoto, Yoshihiko; Matsuyama, Kenji; Hazama, Shoichi; Nagano, Hiroaki; Matsuyama, Hideyasu

2018-03-30

We investigated the relationship between axitinib pharmacogenetics and clinical efficacy/adverse events in advanced renal cell carcinoma (RCC) and established a model to predict clinical efficacy and adverse events using pharmacokinetic and gene polymorphisms related to drug metabolism and efflux in a phase II trial. We prospectively evaluated the area under the plasma concentration-time curve (AUC) of axitinib, objective response rate, and adverse events in 44 consecutive advanced RCC patients treated with axitinib. To establish a model for predicting clinical efficacy and adverse events, polymorphisms in genes including ABC transporters ( ABCB1 and ABCG2 ), UGT1A , and OR2B11 were analyzed by whole-exome sequencing, Sanger sequencing, and DNA microarray. To validate this prediction model, calculated AUC by 6 gene polymorphisms was compared with actual AUC in 16 additional consecutive patients prospectively. Actual AUC significantly correlated with the objective response rate ( P = 0.0002) and adverse events (hand-foot syndrome, P = 0.0055; and hypothyroidism, P = 0.0381). Calculated AUC significantly correlated with actual AUC ( P < 0.0001), and correctly predicted objective response rate ( P = 0.0044) as well as adverse events ( P = 0.0191 and 0.0082, respectively). In the validation study, calculated AUC prior to axitinib treatment precisely predicted actual AUC after axitinib treatment ( P = 0.0066). Our pharmacogenetics-based AUC prediction model may determine the optimal initial dose of axitinib, and thus facilitate better treatment of patients with advanced RCC.

Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma

PubMed Central

Yamamoto, Yoshiaki; Tsunedomi, Ryouichi; Fujita, Yusuke; Otori, Toru; Ohba, Mitsuyoshi; Kawai, Yoshihisa; Hirata, Hiroshi; Matsumoto, Hiroaki; Haginaka, Jun; Suzuki, Shigeo; Dahiya, Rajvir; Hamamoto, Yoshihiko; Matsuyama, Kenji; Hazama, Shoichi; Nagano, Hiroaki; Matsuyama, Hideyasu

2018-01-01

We investigated the relationship between axitinib pharmacogenetics and clinical efficacy/adverse events in advanced renal cell carcinoma (RCC) and established a model to predict clinical efficacy and adverse events using pharmacokinetic and gene polymorphisms related to drug metabolism and efflux in a phase II trial. We prospectively evaluated the area under the plasma concentration–time curve (AUC) of axitinib, objective response rate, and adverse events in 44 consecutive advanced RCC patients treated with axitinib. To establish a model for predicting clinical efficacy and adverse events, polymorphisms in genes including ABC transporters (ABCB1 and ABCG2), UGT1A, and OR2B11 were analyzed by whole-exome sequencing, Sanger sequencing, and DNA microarray. To validate this prediction model, calculated AUC by 6 gene polymorphisms was compared with actual AUC in 16 additional consecutive patients prospectively. Actual AUC significantly correlated with the objective response rate (P = 0.0002) and adverse events (hand-foot syndrome, P = 0.0055; and hypothyroidism, P = 0.0381). Calculated AUC significantly correlated with actual AUC (P < 0.0001), and correctly predicted objective response rate (P = 0.0044) as well as adverse events (P = 0.0191 and 0.0082, respectively). In the validation study, calculated AUC prior to axitinib treatment precisely predicted actual AUC after axitinib treatment (P = 0.0066). Our pharmacogenetics-based AUC prediction model may determine the optimal initial dose of axitinib, and thus facilitate better treatment of patients with advanced RCC. PMID:29682213

Association of Progression of Carotid Artery Wall Volume and Recurrent Transient Ischemic Attack or Stroke: A Magnetic Resonance Imaging Study.

PubMed

Lu, Mingming; Peng, Peng; Cui, Yuanyuan; Qiao, Huiyu; Li, Dongye; Cai, Jianming; Zhao, Xihai

2018-03-01

This study aimed to investigate the association between carotid plaque progression and subsequent recurrent events using magnetic resonance imaging. Sixty-three symptomatic patients with ipsilateral carotid atherosclerotic stenosis (30%-69% stenosis) determined by ultrasound underwent first and second carotid artery magnetic resonance imaging for carotid artery at baseline and ≥6 months after the first scan, respectively. All the patients had clinical follow-up after the second magnetic resonance scan for ≤5 years until the onset of recurrent transient ischemic attack or stroke. Presence/absence of carotid plaque compositional features, particularly intraplaque hemorrhage and fibrous cap rupture was identified. The annual progression of carotid wall volume between 2 magnetic resonance scans was measured. Univariate and multivariate Cox regression was used to calculate the hazard ratio and corresponding 95% confidence interval of carotid plaque features in discriminating recurrent events. Receiver-operating-characteristic-curve analysis was conducted to determine the area-under-the-curve of carotid plaque features in predicting recurrent events. Sixty-three patients (mean age: 66.5±10.0 years old; 54 males) were eligible for final statistics analysis. During a mean follow-up duration of 55.1±13.6 months, 14.3% of patients (n=9) experienced ipsilateral recurrent transient ischemic attack/stroke. The annual progression of carotid wall volume was significantly associated with recurrent events before (hazard ratio, 1.14 per 10 mm 3 ; 95% confidence interval, 1.02-1.27; P =0.019) and after (hazard ratio, 1.19 per 10 mm3; 95% confidence interval, 1.03-1.37; P =0.022) adjusted for confounding factors. In discriminating the recurrence of transient ischemia attack/stroke, receiver-operator curve analysis indicated that combined with annual progression of wall volume, there was a significant incremental improvement in the area-under-the-curve of intraplaque hemorrhage (area-under-the-curve: 0.69-0.81) and fibrous cap rupture (area-under-the-curve: 0.73-0.84). The annual progression of carotid wall volume is independently associated with recurrent ischemic cerebrovascular events, and this measurement has added value for intraplaque hemorrhage and fibrous cap rupture in predicting future events. © 2018 American Heart Association, Inc.

Development of a Bayesian Belief Network Runway Incursion Model

NASA Technical Reports Server (NTRS)

Green, Lawrence L.

2014-01-01

In a previous paper, a statistical analysis of runway incursion (RI) events was conducted to ascertain their relevance to the top ten Technical Challenges (TC) of the National Aeronautics and Space Administration (NASA) Aviation Safety Program (AvSP). The study revealed connections to perhaps several of the AvSP top ten TC. That data also identified several primary causes and contributing factors for RI events that served as the basis for developing a system-level Bayesian Belief Network (BBN) model for RI events. The system-level BBN model will allow NASA to generically model the causes of RI events and to assess the effectiveness of technology products being developed under NASA funding. These products are intended to reduce the frequency of RI events in particular, and to improve runway safety in general. The development, structure and assessment of that BBN for RI events by a Subject Matter Expert panel are documented in this paper.

The predictive value of chronic kidney disease for assessing cardiovascular events under consideration of pretest probability for coronary artery disease in patients who underwent stress myocardial perfusion imaging.

PubMed

Furuhashi, Tatsuhiko; Moroi, Masao; Joki, Nobuhiko; Hase, Hiroki; Masai, Hirofumi; Kunimasa, Taeko; Fukuda, Hiroshi; Sugi, Kaoru

2013-02-01

Pretest probability of coronary artery disease (CAD) facilitates diagnosis and risk stratification of CAD. Stress myocardial perfusion imaging (MPI) and chronic kidney disease (CKD) are established major predictors of cardiovascular events. However, the role of CKD to assess pretest probability of CAD has been unclear. This study evaluates the role of CKD to assess the predictive value of cardiovascular events under consideration of pretest probability in patients who underwent stress MPI. Patients with no history of CAD underwent stress MPI (n = 310; male = 166; age = 70; CKD = 111; low/intermediate/high pretest probability = 17/194/99) and were followed for 24 months. Cardiovascular events included cardiac death and nonfatal acute coronary syndrome. Cardiovascular events occurred in 15 of the 310 patients (4.8 %), but not in those with low pretest probability which included 2 CKD patients. In patients with intermediate to high pretest probability (n = 293), multivariate Cox regression analysis identified only CKD [hazard ratio (HR) = 4.88; P = 0.022) and summed stress score of stress MPI (HR = 1.50; P < 0.001) as independent and significant predictors of cardiovascular events. Cardiovascular events were not observed in patients with low pretest probability. In patients with intermediate to high pretest probability, CKD and stress MPI are independent predictors of cardiovascular events considering the pretest probability of CAD in patients with no history of CAD. In assessing pretest probability of CAD, CKD might be an important factor for assessing future cardiovascular prognosis.

Data-Enabled Quantification of Aluminum Microstructural Damage Under Tensile Loading

NASA Astrophysics Data System (ADS)

Wayne, Steven F.; Qi, G.; Zhang, L.

2016-08-01

The study of material failure with digital analytics is in its infancy and offers a new perspective to advance our understanding of damage initiation and evolution in metals. In this article, we study the failure of aluminum using data-enabled methods, statistics and data mining. Through the use of tension tests, we establish a multivariate acoustic-data matrix of random damage events, which typically are not visible and are very difficult to measure due to their variability, diversity and interactivity during damage processes. Aluminium alloy 6061-T651 and single crystal aluminium with a (111) orientation were evaluated by comparing the collection of acoustic signals from damage events caused primarily by slip in the single crystal and multimode fracture of the alloy. We found the resulting acoustic damage-event data to be large semi-structured volumes of Big Data with the potential to be mined for information that describes the materials damage state under strain. Our data-enabled analyses has allowed us to determine statistical distributions of multiscale random damage that provide a means to quantify the material damage state.

Variables in psychology: a critique of quantitative psychology.

PubMed

Toomela, Aaro

2008-09-01

Mind is hidden from direct observation; it can be studied only by observing behavior. Variables encode information about behaviors. There is no one-to-one correspondence between behaviors and mental events underlying the behaviors, however. In order to understand mind it would be necessary to understand exactly what information is represented in variables. This aim cannot be reached after variables are already encoded. Therefore, statistical data analysis can be very misleading in studies aimed at understanding mind that underlies behavior. In this article different kinds of information that can be represented in variables are described. It is shown how informational ambiguity of variables leads to problems of theoretically meaningful interpretation of the results of statistical data analysis procedures in terms of hidden mental processes. Reasons are provided why presence of dependence between variables does not imply causal relationship between events represented by variables and absence of dependence between variables cannot rule out the causal dependence of events represented by variables. It is concluded that variable-psychology has a very limited range of application for the development of a theory of mind-psychology.

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells

PubMed Central

Nadler, André; Haberkant, Per; Kirkpatrick, Joanna; Schifferer, Martina; Stein, Frank; Hauke, Sebastian; Porter, Forbes D.; Schultz, Carsten

2017-01-01

Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid−protein interactions, and intracellular lipid localization with a single tool per target lipid. The probes are equipped with two photoreactive groups to allow photoliberation (uncaging) and photo–cross-linking in a sequential manner, as well as a click-handle for subsequent functionalization. We demonstrate the versatility of the design for the signaling lipids sphingosine and diacylglycerol; uncaging of the probe for these two species triggered calcium signaling and intracellular protein translocation events, respectively. We performed proteomic screens to map the lipid-interacting proteome for both lipids. Finally, we visualized a sphingosine transport deficiency in patient-derived Niemann−Pick disease type C fibroblasts by fluorescence as well as correlative light and electron microscopy, pointing toward the diagnostic potential of such tools. We envision that this type of probe will become important for analyzing and ultimately understanding lipid signaling events in a comprehensive manner. PMID:28154130

Systematic review on the prevalence, frequency and comparative value of adverse events data in social media

PubMed Central

Golder, Su; Norman, Gill; Loke, Yoon K

2015-01-01

Aim The aim of this review was to summarize the prevalence, frequency and comparative value of information on the adverse events of healthcare interventions from user comments and videos in social media. Methods A systematic review of assessments of the prevalence or type of information on adverse events in social media was undertaken. Sixteen databases and two internet search engines were searched in addition to handsearching, reference checking and contacting experts. The results were sifted independently by two researchers. Data extraction and quality assessment were carried out by one researcher and checked by a second. The quality assessment tool was devised in-house and a narrative synthesis of the results followed. Results From 3064 records, 51 studies met the inclusion criteria. The studies assessed over 174 social media sites with discussion forums (71%) being the most popular. The overall prevalence of adverse events reports in social media varied from 0.2% to 8% of posts. Twenty-nine studies compared the results from searching social media with using other data sources to identify adverse events. There was general agreement that a higher frequency of adverse events was found in social media and that this was particularly true for ‘symptom’ related and ‘mild’ adverse events. Those adverse events that were under-represented in social media were laboratory-based and serious adverse events. Conclusions Reports of adverse events are identifiable within social media. However, there is considerable heterogeneity in the frequency and type of events reported, and the reliability or validity of the data has not been thoroughly evaluated. PMID:26271492

Daily positive events and diurnal cortisol rhythms: Examination of between-person differences and within-person variation.

PubMed

Sin, Nancy L; Ong, Anthony D; Stawski, Robert S; Almeida, David M

2017-09-01

Growing evidence from field studies has linked daily stressors to dysregulated patterns of diurnal cortisol. Less is known about whether naturally-occurring positive events in everyday life are associated with diurnal cortisol. The objectives of this study were to evaluate daily positive events as predictors of between-person differences and within-person (day-to-day) variations in diurnal cortisol parameters, in addition to daily positive events as buffers against the associations between daily stressors and cortisol. In the National Study of Daily Experiences, 1657 adults ages 33-84 (57% female) reported daily experiences during telephone interviews on 8 consecutive evenings. Saliva samples were collected 4 times per day on 4 interview days and assayed for cortisol. Multilevel models were used to estimate associations of daily positive events with cortisol awakening response (CAR), diurnal cortisol slope, and area under the curve (AUC). At the between-person level, people who experienced more frequent positive events exhibited a steeper diurnal cortisol slope, controlling for daily stressors, daily affect, and other covariates. At the within-person level, positive events in the morning (but not prior-night or afternoon/evening events) predicted steeper decline in cortisol across that day; positive events were also marginally associated with lower same-day AUC. Associations were not mediated by daily positive affect, and positive events did not buffer against stressor-related cortisol alterations. These findings indicate that individual differences and day-to-day variations in daily positive events are associated with diurnal cortisol patterns, independent of stressors and affect. Copyright © 2017 Elsevier Ltd. All rights reserved.

Systematic review on the prevalence, frequency and comparative value of adverse events data in social media.

PubMed

Golder, Su; Norman, Gill; Loke, Yoon K

2015-10-01

The aim of this review was to summarize the prevalence, frequency and comparative value of information on the adverse events of healthcare interventions from user comments and videos in social media. A systematic review of assessments of the prevalence or type of information on adverse events in social media was undertaken. Sixteen databases and two internet search engines were searched in addition to handsearching, reference checking and contacting experts. The results were sifted independently by two researchers. Data extraction and quality assessment were carried out by one researcher and checked by a second. The quality assessment tool was devised in-house and a narrative synthesis of the results followed. From 3064 records, 51 studies met the inclusion criteria. The studies assessed over 174 social media sites with discussion forums (71%) being the most popular. The overall prevalence of adverse events reports in social media varied from 0.2% to 8% of posts. Twenty-nine studies compared the results from searching social media with using other data sources to identify adverse events. There was general agreement that a higher frequency of adverse events was found in social media and that this was particularly true for 'symptom' related and 'mild' adverse events. Those adverse events that were under-represented in social media were laboratory-based and serious adverse events. Reports of adverse events are identifiable within social media. However, there is considerable heterogeneity in the frequency and type of events reported, and the reliability or validity of the data has not been thoroughly evaluated. © 2015 The British Pharmacological Society.

Family-based risk factors for non-suicidal self-injury: Considering influences of maltreatment, adverse family-life experiences, and parent-child relational risk.

PubMed

Martin, Jodi; Bureau, Jean-François; Yurkowski, Kim; Fournier, Tania Renaud; Lafontaine, Marie-France; Cloutier, Paula

2016-06-01

The current investigation addressed the potential for unique influences of perceived childhood maltreatment, adverse family-life events, and parent-child relational trauma on the lifetime occurrence and addictive features of non-suicidal self-injury (NSSI). Participants included 957 undergraduate students (747 females; M = 20.14 years, SD = 3.88) who completed online questionnaires regarding the key variables under study. Although self-injuring youth reported more experiences with each family-based risk factor, different patterns of association were found when lifetime engagement in NSSI or its addictive features were under study. Perceived parent-child relational trauma was uniquely linked with NSSI behavior after accounting for perceived childhood maltreatment; adverse family-life events had an additional unique association. In contrast, perceived paternal maltreatment was uniquely related with NSSI's addictive features. Findings underline the importance of studying inter-related family-based risk factors of NSSI simultaneously for a comprehensive understanding of familial correlates of NSSI behavior and its underlying features. Copyright © 2016 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

76 FR 17727 - Self-Regulatory Organizations; The Options Clearing Corporation; Order Approving Proposed Rule...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-30

... options on certain indexes measuring the relative performance of one reference security or reference index... one underlying stock and one underlying ETF, which are also traded on the Phlx.\\5\\ An Alpha Index is...-settled, European-style options. In the event of a corporate event that eliminates one of the underlying...

The role of guessing and boundaries on date estimation biases.

PubMed

Lee, Peter James; Brown, Norman R

2004-08-01

This study investigates the causes of event-dating biases. Two hundred participants provided knowledge ratings and date estimates for 64 news events. Four independent groups dated the same events under different boundary constraints. Analysis across all responses showed that forward telescoping decreased with boundary age, concurring with the boundary-effects model. With guesses removed from the data set, backward telescoping was greatly reduced, but forward telescoping was unaffected by boundaries. This dissociation indicates that multiple factors (e.g., guessing and reconstructive strategies) are responsible for different dating biases and argue against a boundary explanation of forward telescoping.

Comparison of Event Detection Methods for Centralized Sensor Networks

NASA Technical Reports Server (NTRS)

Sauvageon, Julien; Agogiono, Alice M.; Farhang, Ali; Tumer, Irem Y.

2006-01-01

The development of an Integrated Vehicle Health Management (IVHM) for space vehicles has become a great concern. Smart Sensor Networks is one of the promising technologies that are catching a lot of attention. In this paper, we propose to a qualitative comparison of several local event (hot spot) detection algorithms in centralized redundant sensor networks. The algorithms are compared regarding their ability to locate and evaluate the event under noise and sensor failures. The purpose of this study is to check if the ratio performance/computational power of the Mote Fuzzy Validation and Fusion algorithm is relevant compare to simpler methods.

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2011 CFR

2011-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2012 CFR

2012-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2014 CFR

2014-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

29 CFR 4043.32 - Transfer of benefit liabilities.

Code of Federal Regulations, 2013 CFR

2013-07-01

... REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.32 Transfer of benefit liabilities. (a) Reportable event—(1) In general. A reportable event occurs... notice of a reportable event under this section. Notice by any other contributing sponsor or plan...

Differential Neural Activity during Search of Specific and General Autobiographical Memories elicited by Musical Cues

PubMed Central

Ford, Jaclyn Hennessey; Addis, Donna Rose; Giovanello, Kelly S.

2011-01-01

Previous neuroimaging studies that have examined autobiographical memory specificity have utilized retrieval cues associated with prior searches of the event, potentially changing the retrieval processes being investigated. In the current study, musical cues were used to naturally elicit memories from multiple levels of specificity (i.e., lifetime period, general event, and event-specific). Sixteen young adults participated in a neuroimaging study in which they retrieved autobiographical memories associated with musical cues. These musical cues led to the retrieval of highly emotional memories that had low levels of prior retrieval. Retrieval of all autobiographical memory levels was associated with activity in regions in the autobiographical memory network, specifically the ventromedial prefrontal cortex, posterior cingulate, and right medial temporal lobe. Owing to the use of music, memories from varying levels of specificity were retrieved, allowing for comparison of event memory and abstract personal knowledge, as well as comparison of specific and general event memory. Dorsolateral and dorsomedial prefrontal regions were engaged during event retrieval relative to personal knowledge retrieval, and retrieval of specific event memories was associated with increased activity in the bilateral medial temporal lobe and dorsomedial prefrontal cortex relative to retrieval of general event memories. These results suggest that the initial search processes for memories of different specificity levels preferentially engage different components of the autobiographical memory network. The potential underlying causes of these neural differences are discussed. PMID:21600227

Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema: The ALESSA Score Study.

PubMed

Paciaroni, Maurizio; Agnelli, Giancarlo; Caso, Valeria; Tsivgoulis, Georgios; Furie, Karen L; Tadi, Prasanna; Becattini, Cecilia; Falocci, Nicola; Zedde, Marialuisa; Abdul-Rahim, Azmil H; Lees, Kennedy R; Alberti, Andrea; Venti, Michele; Acciarresi, Monica; D'Amore, Cataldo; Mosconi, Maria Giulia; Cimini, Ludovica Anna; Procopio, Antonio; Bovi, Paolo; Carletti, Monica; Rigatelli, Alberto; Cappellari, Manuel; Putaala, Jukka; Tomppo, Liisa; Tatlisumak, Turgut; Bandini, Fabio; Marcheselli, Simona; Pezzini, Alessandro; Poli, Loris; Padovani, Alessandro; Masotti, Luca; Vannucchi, Vieri; Sohn, Sung-Il; Lorenzini, Gianni; Tassi, Rossana; Guideri, Francesca; Acampa, Maurizio; Martini, Giuseppe; Ntaios, George; Karagkiozi, Efstathia; Athanasakis, George; Makaritsis, Kostantinos; Vadikolias, Kostantinos; Liantinioti, Chrysoula; Chondrogianni, Maria; Mumoli, Nicola; Consoli, Domenico; Galati, Franco; Sacco, Simona; Carolei, Antonio; Tiseo, Cindy; Corea, Francesco; Ageno, Walter; Bellesini, Marta; Colombo, Giovanna; Silvestrelli, Giorgio; Ciccone, Alfonso; Scoditti, Umberto; Denti, Licia; Mancuso, Michelangelo; Maccarrone, Miriam; Orlandi, Giovanni; Giannini, Nicola; Gialdini, Gino; Tassinari, Tiziana; De Lodovici, Maria Luisa; Bono, Giorgio; Rueckert, Christina; Baldi, Antonio; D'Anna, Sebastiano; Toni, Danilo; Letteri, Federica; Giuntini, Martina; Lotti, Enrico Maria; Flomin, Yuriy; Pieroni, Alessio; Kargiotis, Odysseas; Karapanayiotides, Theodore; Monaco, Serena; Baronello, Mario Maimone; Csiba, Laszló; Szabó, Lilla; Chiti, Alberto; Giorli, Elisa; Del Sette, Massimo; Imberti, Davide; Zabzuni, Dorjan; Doronin, Boris; Volodina, Vera; Michel, Patrik; Vanacker, Peter; Barlinn, Kristian; Pallesen, Lars-Peder; Kepplinger, Jessica; Bodechtel, Ulf; Gerber, Johannes; Deleu, Dirk; Melikyan, Gayane; Ibrahim, Faisal; Akhtar, Naveed; Gourbali, Vanessa; Yaghi, Shadi

2017-03-01

This study was designed to derive and validate a score to predict early ischemic events and major bleedings after an acute ischemic stroke in patients with atrial fibrillation. The derivation cohort consisted of 854 patients with acute ischemic stroke and atrial fibrillation included in prospective series between January 2012 and March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) and severe atrial enlargement (hazard ratio, 2.05; 95% confidence interval, 1.08-2.87) were predictors for ischemic outcome events (stroke, transient ischemic attack, and systemic embolism) at 90 days from acute stroke. Small lesions (≤1.5 cm) were inversely correlated with both major bleeding (hazard ratio, 0.39; P =0.03) and ischemic outcome events (hazard ratio, 0.55; 95% confidence interval, 0.30-1.00). We assigned to age ≥80 years 2 points and between 70 and 79 years 1 point; ischemic index lesion >1.5 cm, 1 point; severe atrial enlargement, 1 point (ALESSA score). A logistic regression with the receiver-operating characteristic graph procedure (C statistic) showed an area under the curve of 0.697 (0.632-0.763; P =0.0001) for ischemic outcome events and 0.585 (0.493-0.678; P =0.10) for major bleedings. The validation cohort consisted of 994 patients included in prospective series between April 2014 and June 2016. Logistic regression with the receiver-operating characteristic graph procedure showed an area under the curve of 0.646 (0.529-0.763; P =0.009) for ischemic outcome events and 0.407 (0.275-0.540; P =0.14) for hemorrhagic outcome events. In acute stroke patients with atrial fibrillation, high ALESSA scores were associated with a high risk of ischemic events but not of major bleedings. © 2017 American Heart Association, Inc.

Stressful life events, sexual orientation, and cardiometabolic risk among young adults in the United States.

PubMed

Hatzenbuehler, Mark L; Slopen, Natalie; McLaughlin, Katie A; McLaughlin, Kate A

2014-10-01

The goal of the present study was to examine whether sexual minority young adults are more vulnerable to developing cardiometabolic risk following exposure to stressful life events than heterosexual young adults. Data came from the National Longitudinal Study for Adolescent Health (Shin, Edwards, & Heeren, 2009; Brummett et al., 2013), a prospective nationally representative study of U.S. adolescents followed into young adulthood. A total of 306 lesbian, gay, and bisexual (LGB) respondents and 6,667 heterosexual respondents met inclusion criteria for this analysis. Measures of cumulative stressful life events were drawn from all 4 waves of data collection; sexual orientation and cardiometabolic biomarkers were assessed at Wave 4 (2008-2009). Gay/bisexual men exposed to 1-2 (β = 0.71, p = .01) and 5+ (β = 0.87, p = .01) stressful life events had a statistically significant elevation in cardiometabolic risk, controlling for demographics, health behaviors, and socioeconomic status. Moreover, in models adjusted for all covariates, lesbian/bisexual (β = 0.52, p = .046) women with 5+ stressful life events had a statistically significant elevation in cardiometabolic risk. There was no relationship between stressful life events and cardiometabolic risk among heterosexual men or women. Stressful life events during childhood, adolescence, and young adulthood place LGB young adults at heightened risk for elevated cardiometabolic risk as early as young adulthood. The mechanisms underlying this relationship require future study.

Empirical study of a unidirectional dense crowd during a real mass event

NASA Astrophysics Data System (ADS)

Zhang, X. L.; Weng, W. G.; Yuan, H. Y.; Chen, J. G.

2013-06-01

Many tragic crowd disasters have happened across the world in recent years, such as the Phnom Penh stampede in Cambodia, crowd disaster in Mina/Makkah, and the Love Parade disaster in Germany, showing that management of mass events is a tough task for organizers. The study of unidirectional flow, one of the most common forms of motion in mass activities, is essential for safe organization of such events. In this paper, the properties of unidirectional flow in a crowded street during a real mass event in China are quantitatively investigated with sophisticated active infrared counters and an image processing method. A complete dataset of flow rates during the whole celebration is recorded, and a time series analysis gives new insight into such activities. The spatial analysis shows that the velocity and density of the crowd are inhomogeneous due to the boundary effect, whereas the flux is uniform. The estimated capacity of the street indicates that the maximum flow rate under normal condition should be between 1.73 and 1.98 /m/s, which is in good agreement with several field studies available in the existing literature. In consideration of the significant deviation among different studies, fundamental diagrams of dense crowds are also re-verified, and the results here are consistent with those from other field studies of unidirectional flow, but different from the bidirectional and experimental results. It is suggested that the data from multidirectional flow and experiments cannot be directly applied to unidirectional dense flow in a real mass event. The results also imply that the density of a similar unidirectional marching crowd should be controlled to be under 5 /m2, which can produce optimal efficiency and have more possibility to ensure safety. The field study data given here provide a good example of a database for crowd studies.

Measurement of dijet k T in p–Pb collisions at s NN = 5.02 TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adam, J.

A measurement of dijet correlations in p–Pb collisions at √s NN = 5.02 TeV with the ALICE detector is presented. Jets are reconstructed from charged particles measured in the central tracking detectors and neutral energy deposited in the electromagnetic calorimeter. The transverse momentum of the full jet (clustered from charged and neutral constituents) and charged jet (clustered from charged particles only) is corrected event-by-event for the contribution of the underlying event, while corrections for underlying event fluctuations and finite detector resolution are applied on an inclusive basis. A projection of the dijet transverse momentum, k Ty = p T,jet ch+nesin(Δmore » φdijet) with Δ φdijet the azimuthal angle between a full and charged jet and p T,jet ch+ne the transverse momentum of the full jet, is used to study nuclear matter effects in p–Pb collisions. This observable is sensitive to the acoplanarity of dijet production and its potential modification in p–Pb collisions with respect to pp collisions. Here, measurements of the dijet k Ty as a function of the transverse momentum of the full and recoil charged jet, and the event multiplicity are presented. No significant modification of k Ty due to nuclear matter effects in p–Pb collisions with respect to the event multiplicity or a PYTHIA8 reference is observed.« less

Measurement of dijet k T in p–Pb collisions at s NN = 5.02 TeV

DOE PAGES

Adam, J.

2015-05-19

A measurement of dijet correlations in p–Pb collisions at √s NN = 5.02 TeV with the ALICE detector is presented. Jets are reconstructed from charged particles measured in the central tracking detectors and neutral energy deposited in the electromagnetic calorimeter. The transverse momentum of the full jet (clustered from charged and neutral constituents) and charged jet (clustered from charged particles only) is corrected event-by-event for the contribution of the underlying event, while corrections for underlying event fluctuations and finite detector resolution are applied on an inclusive basis. A projection of the dijet transverse momentum, k Ty = p T,jet ch+nesin(Δmore » φdijet) with Δ φdijet the azimuthal angle between a full and charged jet and p T,jet ch+ne the transverse momentum of the full jet, is used to study nuclear matter effects in p–Pb collisions. This observable is sensitive to the acoplanarity of dijet production and its potential modification in p–Pb collisions with respect to pp collisions. Here, measurements of the dijet k Ty as a function of the transverse momentum of the full and recoil charged jet, and the event multiplicity are presented. No significant modification of k Ty due to nuclear matter effects in p–Pb collisions with respect to the event multiplicity or a PYTHIA8 reference is observed.« less

Measurement of the dependence of transverse energy production at large pseudorapidity on the hard-scattering kinematics of proton–proton collisions at √s = 2.76 TeV with ATLAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aad, G.

2016-03-02

The relationship between jet production in the central region and the underlying-event activity in a pseudorapidity-separated region is studied in 4.0 pb -1 of √s = 2.76 TeV pp collision data recorded with the ATLAS detector at the LHC. The underlying event is characterised through measurements of the average value of the sum of the transverse energy at large pseudorapidity downstream of one of the protons, which are reported here as a function of hard-scattering kinematic variables. The hard scattering is characterised by the average transverse momentum and pseudorapidity of the two highest transverse momentum jets in the event. Themore » dijet kinematics are used to estimate, on an event-by-event basis, the scaled longitudinal momenta of the hard-scattered partons in the target and projectile beam-protons moving toward and away from the region measuring transverse energy, respectively. Transverse energy production at large pseudorapidity is observed to decrease with a linear dependence on the longitudinal momentum fraction in the target proton and to depend only weakly on that in the projectile proton. Lastly, the results are compared to the predictions of various Monte Carlo event generators, which qualitatively reproduce the trends observed in data but generally underpredict the overall level of transverse energy at forward pseudorapidity.« less

Root cause analysis of serious adverse events among older patients in the Veterans Health Administration.

PubMed

Lee, Alexandra; Mills, Peter D; Neily, Julia; Hemphill, Robin R

2014-06-01

Preventable adverse events are more likely to occur among older patients because of the clinical complexity of their care. The Veterans Health Administration (VHA) National Center for Patient Safety (NCPS) stores data about serious adverse events when a root cause analysis (RCA) has been performed. A primary objective of this study was to describe the types of adverse events occurring among older patients (age > or = 65 years) in Department of Veterans Affairs (VA) hospitals. Secondary objectives were to determine the underlying reasons for the occurrence of these events and report on effective action plans that have been implemented in VA hospitals. In a retrospective, cross-sectional review, RCA reports were reviewed and outcomes reported using descriptive statistics for all VA hospitals that conducted an RCA for a serious geriatric adverse event from January 2010 to January 2011 that resulted in sustained injury or death. The search produced 325 RCA reports on VA patients (age > or = 65 years). Falls (34.8%), delays in diagnosis and/or treatment (11.7%), unexpected death (9.9%), and medication errors (9.0%) were the most commonly reported adverse events among older VA patients. Communication was the most common underlying reason for these events, representing 43.9% of reported root causes. Approximately 40% of implemented action plans were judged by local staff to be effective. The RCA process identified falls and communication as important themes in serious adverse events. Concrete actions, such as process standardization and changes to communication, were reported by teams to yield some improvement. However, fewer than half of the action plans were reported to be effective. Further research is needed to guide development and implementation of effective action plans.

Recovery process and determinants of adverse event occurrence in bronchoscopic procedures performed under general anaesthesia.

PubMed

Özden Omaygenç, Derya; Ünal, Nermin; Edipoğlu, Saadet İpek; Barca Şeker, Tuğçe; Özgül, Mehmet Akif; Turan, Demet; Özdemir, Cengiz; Karaca, İbrahim Oğuz; Çetinkaya, Erdoğan

2018-04-16

Regarding the fact that rigid bronchoscopy is generally performed under general anaesthesia and this patient subgroup is remarkably morbid, encountering procedure and/or anaesthesia related complications are highly likely. Here, we aimed to assess factors influencing recovery and detect possible determinants of adverse event occurrence during these operations performed in a tertiary referral centre. Eighty-one consecutive ASA I-IV patients were recruited for this investigation. In the operating theatre after induction of anaesthesia and advancement of the device, maintenance was provided with total intravenous anaesthesia. Neuromuscular blockage was invariably administered, and patients were ventilated manually. In addition to preoperative demographic and procedural characteristics, perioperative hemodynamic variables, recovery times and observed adverse events were noted. Basic demographic properties, ASA and Mallampati scores, and procedure specific variables as lesion localization, lesion and procedure type were comparable among groups assembled with reference to event occurrence. Patients who had experienced adverse event had higher heart rates. Recovery times were comparable between Event (-) and Event (+) groups. Relationship of recovery process were individually tested with all variables and only lesion type was detected to have an effect on respiration and extubation times. Among all parameters only procedural time seemed to be associated with adverse event occurrence (mins, 22.9 ± 11.9 vs 41.6 ± 28.8, P < .001). Recovery times related with return of spontaneous respiration were significantly lower in procedures performed for treatment of tumoral diseases in this study and procedure length was determined to be the ultimate factor which had an impact on adverse event occurrence. © 2018 John Wiley & Sons Ltd.

Citizens under Suspicion: Responsive Research with Community under Surveillance

ERIC Educational Resources Information Center

Ali, Arshad Imitaz

2016-01-01

In the 14 years since the 9/11 events, this nation as a whole, and New York City in particular, has escalated its state-sanctioned surveillance in the lives and activities of Muslims in the United States. This qualitative study examines the ramifications of police infiltration and monitoring of Muslim student and community-based organizations.…

Differential Effects of Aging on Processes Underlying Task Switching

ERIC Educational Resources Information Center

West, Robert; Travers, Stephanie

2008-01-01

In this study, we used event-related brain potentials (ERPs) to examine the effects of aging on processes underlying task switching. The response time data revealed an age-related increase in mixing costs before controlling for general slowing and no effect of aging on switching costs. In the cue-locked epoch, the ERP data revealed little effect…

Diagnosis of condensation-induced waterhammer: Methods and background

DOE Office of Scientific and Technical Information (OSTI.GOV)

Izenson, M.G.; Rothe, P.H.; Wallis, G.B.

This guidebook provides reference material and diagnostic procedures concerning condensation-induced waterhammer in nuclear power plants. Condensation-induced waterhammer is the most damaging form of waterhammer and its diagnosis is complicated by the complex nature of the underlying phenomena. In Volume 1, the guidebook groups condensation-induced waterhammers into five event classes which have similar phenomena and levels of damage. Diagnostic guidelines focus on locating the event center where condensation and slug acceleration take place. Diagnosis is described in three stages: an initial assessment, detailed evaluation and final confirmation. Graphical scoping analyses are provided to evaluate whether an event from one of themore » event classes could have occurred at the event center. Examples are provided for each type of waterhammer. Special instructions are provided for walking down damaged piping and evaluating damage due to waterhammer. To illustrate the diagnostic methods and document past experience, six case studies have been compiled in Volume 2. These case studies, based on actual condensation-induced waterhammer events at nuclear plants, present detailed data and work through the event diagnosis using the tools introduced in the first volume. 65 figs., 8 tabs.« less

Fatal and non-fatal cardiovascular events in a general population prescribed sibutramine in New Zealand: a prospective cohort study.

PubMed

Harrison-Woolrych, Mira; Ashton, Janelle; Herbison, Peter

2010-07-01

The cardiovascular safety of sibutramine is currently under review by medicines regulatory authorities worldwide after the SCOUT (Sibutramine Cardiovascular Outcome Trial) showed an increased risk of cardiovascular events in patients taking sibutramine. Further data regarding the cardiovascular safety of sibutramine in a general population are now required. To quantify the risk of fatal and non-fatal cardiovascular adverse events in a general population prescribed sibutramine in postmarketing use. Observational prospective cohort study of patients dispensed sibutramine during a 3-year period (2001-4) and followed up for at least 1 year after their last prescription. The study included record-linkage to national mortality datasets to identify fatal events. Postmarketing 'real-life' use of sibutramine in a general population in New Zealand. All New Zealand patients dispensed a prescription for sibutramine in a 3-year period (for whom a National Health Identification number could be validated). 15 686 patients were included in the record linkage study for fatal events. A subgroup of 9471 patients was followed up by intensive methods for non-fatal events. (i) Rate of death from all causes and from cardiovascular events; and (ii) rates of non-fatal cardiovascular adverse events. Total exposure to sibutramine for 15 686 patients in the validated cohort was 5431 treatment-years. The rate of death from all causes in this cohort was 0.13 (95% CI 0.05, 0.27) per 100 treatment-years exposure. The rate of death from a cardiovascular event was 0.07 (95% CI 0.02, 0.19) per 100 treatment-years exposure. The most frequent non-fatal cardiovascular events in the intensively followed up cohort were hypertension, palpitations, hypotensive events and tachycardia. Risk of death from a cardiovascular event in this general population of patients prescribed sibutramine was lower than has been reported in other overweight/obese populations. The results of this study suggest that further evaluation of the benefit-risk profile of sibutramine is now required.

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

29 CFR 4043.25 - Failure to make required minimum funding payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TERMINATIONS REPORTABLE EVENTS AND CERTAIN OTHER NOTIFICATION REQUIREMENTS Post-Event Notice of Reportable Events § 4043.25 Failure to make required minimum funding payment. (a) Reportable event. A reportable event occurs when a required installment or a payment required under section 302 of ERISA or section 412...

Dense cold baryonic matter

NASA Astrophysics Data System (ADS)

Stavinskiy, A. V.

2017-09-01

A possibility of studying cold nuclear matter on the Nuclotron-NICA facility at baryonic densities characteristic of and higher than at the center of a neutron star is considered based on the data from cumulative processes. A special rare-event kinematic trigger for collisions of relativistic ions is proposed for effective selection of events accompanied by production of dense baryonic systems. Possible manifestations of new matter states under these unusual conditions and an experimental program for their study are discussed. Various experimental setups are proposed for these studies, and a possibility of using experimental setups at the Nuclotron-NICA facility for this purpose is considered.

Hydrochemical responses among nested catchments of the Sleepers River Research Watershed.

NASA Astrophysics Data System (ADS)

Sebestyen, S. D.; Boyer, E. W.; Shanley, J. B.; Kendall, C.

2005-12-01

We are probing chemical and isotopic tracers of dissolved organic carbon (DOC) and nitrate over both space and time to determine how stream nutrient dynamics change with increasing basin size and differ with flow conditions. At the Sleepers River Research Watershed in northeastern Vermont, USA, 20 to 30 nested sub-basins that ranged in size from 3 to 11,000 ha were sampled repeatedly under baseflow conditions. These synoptic surveys showed a pattern of heterogeneity in headwaters that converged to a consistent response at larger basin sizes and is consistent with findings of other studies. In addition to characterizing spatial patterns under baseflow, we sampled rainfall and snowmelt events over a gradient of basin sizes to investigate scaling responses under different flow conditions. During high flow events, DOC and nitrate flushing responses varied among different basins where high-frequency event samples were collected. While the DOC and nitrate concentration patterns were similar at four headwater basins, the concentration responses of larger basins were markedly different in that the concentration patterns, flushing duration, and maximum concentrations were attenuated from headwaters to the largest basin. We are using these data to explore how flow paths and solute mixing aggregate. Overall, these results highlight the complexities of understanding spatial scaling issues in catchments and underscore the need to consider event responses of hydrology and chemistry among catchments.

Risk analysis for the flood control capacity of dikes under climate change

NASA Astrophysics Data System (ADS)

Wei, Hsiao Ping; Yeh, Keh-Chia; Hsiao, Yi-Hua

2017-04-01

Climate change is the major reason for many extreme disaster events. In recent years, scientists have revealed many findings and most of them agree that the frequency of extreme weather and its corresponding hydrological impact will increase due to climate change. In such situation, the current hydrologic designs based upon historical observation, which could be changed, are necessary to review again under the scenario of climate change. It is for this reason that this study uses Kao-Ping River Basin as an example, using high resolution dynamical downscaling data (base period, near future, and end of the century) to simulate changes in hourly flow rate of typhoon events in each of the three 25-year periods. Results are further compared with the design flow rate announced by the competent authority of water resources, as well as recorded river water levels of the most severe typhoon event in history and risk analysis basic on factors, to evaluate the risk and impact of river flooding under climate change.From the simulation results, the frequency of exceeding design discharge in Kao-ping river catchment will increase in the end of century. The water level at these LI-LIN BRIDGE and SAN-TI-MEN gauges could be obviously influenced due to the extreme rainfall events, so that their flood control capacity should be assessed and improved.

Probiotic and synbiotic safety in infants under two years of age.

PubMed

van den Nieuwboer, M; Claassen, E; Morelli, L; Guarner, F; Brummer, R J

2014-03-01

In this study, we systematically evaluated safety aspects in clinical trials with probiotics and synbiotics in young infants (0-2 years of age). This study is an update of earlier reports and covers the recent literature from 2008-2013. The safety evaluation is performed along the Common Terminology Clinical Adverse Events (CTCAE) version 4.0 scale, hereby also providing guidance for future studies. Safety aspects are represented and related to number of participants per probiotic strain/culture, study duration, dosage, clinical condition and selected afflictions. The results show a deficiency in the precise reporting and classification of adverse events in most studies. Analysis of 57 clinical trials with probiotics and synbiotics in combination with eight follow-up studies indicate that probiotic administration to infants between 0 and 24 months is safe with regard to the evaluated strains in infants with a particular health status or susceptibility. Most adverse events and serious adverse events were considered unrelated to the study product, and there were no major safety concerns. Almost all studies concluded that none of the adverse effects were related to the study product; the study products are generally well tolerated. Finally, inconsistent, imprecise and potentially incomplete reporting as well as the variation in probiotic strains, dosages, administration regimes, study populations and reported outcomes, greatly limit the generalizability of conclusions and argue convincingly for obligatory and standardised behaviour on adverse events (CTCAE) reporting in 'food' studies.

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.

PubMed

Machiela, Mitchell J; Zhou, Weiyin; Karlins, Eric; Sampson, Joshua N; Freedman, Neal D; Yang, Qi; Hicks, Belynda; Dagnall, Casey; Hautman, Christopher; Jacobs, Kevin B; Abnet, Christian C; Aldrich, Melinda C; Amos, Christopher; Amundadottir, Laufey T; Arslan, Alan A; Beane-Freeman, Laura E; Berndt, Sonja I; Black, Amanda; Blot, William J; Bock, Cathryn H; Bracci, Paige M; Brinton, Louise A; Bueno-de-Mesquita, H Bas; Burdett, Laurie; Buring, Julie E; Butler, Mary A; Canzian, Federico; Carreón, Tania; Chaffee, Kari G; Chang, I-Shou; Chatterjee, Nilanjan; Chen, Chu; Chen, Constance; Chen, Kexin; Chung, Charles C; Cook, Linda S; Crous Bou, Marta; Cullen, Michael; Davis, Faith G; De Vivo, Immaculata; Ding, Ti; Doherty, Jennifer; Duell, Eric J; Epstein, Caroline G; Fan, Jin-Hu; Figueroa, Jonine D; Fraumeni, Joseph F; Friedenreich, Christine M; Fuchs, Charles S; Gallinger, Steven; Gao, Yu-Tang; Gapstur, Susan M; Garcia-Closas, Montserrat; Gaudet, Mia M; Gaziano, J Michael; Giles, Graham G; Gillanders, Elizabeth M; Giovannucci, Edward L; Goldin, Lynn; Goldstein, Alisa M; Haiman, Christopher A; Hallmans, Goran; Hankinson, Susan E; Harris, Curtis C; Henriksson, Roger; Holly, Elizabeth A; Hong, Yun-Chul; Hoover, Robert N; Hsiung, Chao A; Hu, Nan; Hu, Wei; Hunter, David J; Hutchinson, Amy; Jenab, Mazda; Johansen, Christoffer; Khaw, Kay-Tee; Kim, Hee Nam; Kim, Yeul Hong; Kim, Young Tae; Klein, Alison P; Klein, Robert; Koh, Woon-Puay; Kolonel, Laurence N; Kooperberg, Charles; Kraft, Peter; Krogh, Vittorio; Kurtz, Robert C; LaCroix, Andrea; Lan, Qing; Landi, Maria Teresa; Marchand, Loic Le; Li, Donghui; Liang, Xiaolin; Liao, Linda M; Lin, Dongxin; Liu, Jianjun; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M; Malats, Nuria; Matsuo, Keitaro; McNeill, Lorna H; McWilliams, Robert R; Melin, Beatrice S; Mirabello, Lisa; Moore, Lee; Olson, Sara H; Orlow, Irene; Park, Jae Yong; Patiño-Garcia, Ana; Peplonska, Beata; Peters, Ulrike; Petersen, Gloria M; Pooler, Loreall; Prescott, Jennifer; Prokunina-Olsson, Ludmila; Purdue, Mark P; Qiao, You-Lin; Rajaraman, Preetha; Real, Francisco X; Riboli, Elio; Risch, Harvey A; Rodriguez-Santiago, Benjamin; Ruder, Avima M; Savage, Sharon A; Schumacher, Fredrick; Schwartz, Ann G; Schwartz, Kendra L; Seow, Adeline; Wendy Setiawan, Veronica; Severi, Gianluca; Shen, Hongbing; Sheng, Xin; Shin, Min-Ho; Shu, Xiao-Ou; Silverman, Debra T; Spitz, Margaret R; Stevens, Victoria L; Stolzenberg-Solomon, Rachael; Stram, Daniel; Tang, Ze-Zhong; Taylor, Philip R; Teras, Lauren R; Tobias, Geoffrey S; Van Den Berg, David; Visvanathan, Kala; Wacholder, Sholom; Wang, Jiu-Cun; Wang, Zhaoming; Wentzensen, Nicolas; Wheeler, William; White, Emily; Wiencke, John K; Wolpin, Brian M; Wong, Maria Pik; Wu, Chen; Wu, Tangchun; Wu, Xifeng; Wu, Yi-Long; Wunder, Jay S; Xia, Lucy; Yang, Hannah P; Yang, Pan-Chyr; Yu, Kai; Zanetti, Krista A; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Zhou, Baosen; Ziegler, Regina G; Perez-Jurado, Luis A; Caporaso, Neil E; Rothman, Nathaniel; Tucker, Margaret; Dean, Michael C; Yeager, Meredith; Chanock, Stephen J

2016-06-13

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases.

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

PubMed Central

Machiela, Mitchell J.; Zhou, Weiyin; Karlins, Eric; Sampson, Joshua N.; Freedman, Neal D.; Yang, Qi; Hicks, Belynda; Dagnall, Casey; Hautman, Christopher; Jacobs, Kevin B.; Abnet, Christian C.; Aldrich, Melinda C.; Amos, Christopher; Amundadottir, Laufey T.; Arslan, Alan A.; Beane-Freeman, Laura E.; Berndt, Sonja I.; Black, Amanda; Blot, William J.; Bock, Cathryn H.; Bracci, Paige M.; Brinton, Louise A.; Bueno-de-Mesquita, H Bas; Burdett, Laurie; Buring, Julie E.; Butler, Mary A.; Canzian, Federico; Carreón, Tania; Chaffee, Kari G.; Chang, I-Shou; Chatterjee, Nilanjan; Chen, Chu; Chen, Constance; Chen, Kexin; Chung, Charles C.; Cook, Linda S.; Crous Bou, Marta; Cullen, Michael; Davis, Faith G.; De Vivo, Immaculata; Ding, Ti; Doherty, Jennifer; Duell, Eric J.; Epstein, Caroline G.; Fan, Jin-Hu; Figueroa, Jonine D.; Fraumeni, Joseph F.; Friedenreich, Christine M.; Fuchs, Charles S.; Gallinger, Steven; Gao, Yu-Tang; Gapstur, Susan M.; Garcia-Closas, Montserrat; Gaudet, Mia M.; Gaziano, J. Michael; Giles, Graham G.; Gillanders, Elizabeth M.; Giovannucci, Edward L.; Goldin, Lynn; Goldstein, Alisa M.; Haiman, Christopher A.; Hallmans, Goran; Hankinson, Susan E.; Harris, Curtis C.; Henriksson, Roger; Holly, Elizabeth A.; Hong, Yun-Chul; Hoover, Robert N.; Hsiung, Chao A.; Hu, Nan; Hu, Wei; Hunter, David J.; Hutchinson, Amy; Jenab, Mazda; Johansen, Christoffer; Khaw, Kay-Tee; Kim, Hee Nam; Kim, Yeul Hong; Kim, Young Tae; Klein, Alison P.; Klein, Robert; Koh, Woon-Puay; Kolonel, Laurence N.; Kooperberg, Charles; Kraft, Peter; Krogh, Vittorio; Kurtz, Robert C.; LaCroix, Andrea; Lan, Qing; Landi, Maria Teresa; Marchand, Loic Le; Li, Donghui; Liang, Xiaolin; Liao, Linda M.; Lin, Dongxin; Liu, Jianjun; Lissowska, Jolanta; Lu, Lingeng; Magliocco, Anthony M.; Malats, Nuria; Matsuo, Keitaro; McNeill, Lorna H.; McWilliams, Robert R.; Melin, Beatrice S.; Mirabello, Lisa; Moore, Lee; Olson, Sara H.; Orlow, Irene; Park, Jae Yong; Patiño-Garcia, Ana; Peplonska, Beata; Peters, Ulrike; Petersen, Gloria M.; Pooler, Loreall; Prescott, Jennifer; Prokunina-Olsson, Ludmila; Purdue, Mark P.; Qiao, You-Lin; Rajaraman, Preetha; Real, Francisco X.; Riboli, Elio; Risch, Harvey A.; Rodriguez-Santiago, Benjamin; Ruder, Avima M.; Savage, Sharon A.; Schumacher, Fredrick; Schwartz, Ann G.; Schwartz, Kendra L.; Seow, Adeline; Wendy Setiawan, Veronica; Severi, Gianluca; Shen, Hongbing; Sheng, Xin; Shin, Min-Ho; Shu, Xiao-Ou; Silverman, Debra T.; Spitz, Margaret R.; Stevens, Victoria L.; Stolzenberg-Solomon, Rachael; Stram, Daniel; Tang, Ze-Zhong; Taylor, Philip R.; Teras, Lauren R.; Tobias, Geoffrey S.; Van Den Berg, David; Visvanathan, Kala; Wacholder, Sholom; Wang, Jiu-Cun; Wang, Zhaoming; Wentzensen, Nicolas; Wheeler, William; White, Emily; Wiencke, John K.; Wolpin, Brian M.; Wong, Maria Pik; Wu, Chen; Wu, Tangchun; Wu, Xifeng; Wu, Yi-Long; Wunder, Jay S.; Xia, Lucy; Yang, Hannah P.; Yang, Pan-Chyr; Yu, Kai; Zanetti, Krista A.; Zeleniuch-Jacquotte, Anne; Zheng, Wei; Zhou, Baosen; Ziegler, Regina G.; Perez-Jurado, Luis A.; Caporaso, Neil E.; Rothman, Nathaniel; Tucker, Margaret; Dean, Michael C.; Yeager, Meredith; Chanock, Stephen J.

2016-01-01

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases. PMID:27291797

Driving along the Road or Heading for the Village? Conceptual Differences Underlying Motion Event Encoding in French, German, and French-German L2 Users

ERIC Educational Resources Information Center

Flecken, Monique; Carroll, Mary; Weimar, Katja; Von Stutterheim, Christiane

2015-01-01

The typological contrast between verb- and satellite-framed languages (Talmy, 1985) has set the basis for many empirical studies on L2 acquisition. The current analysis goes beyond this typology by looking in detail at the conceptualization of the path of motion in a motion event. We take as a starting point the cognitive salience of specific…

An islanding detection methodology combining decision trees and Sandia frequency shift for inverter-based distributed generations

DOE PAGES

Azim, Riyasat; Li, Fangxing; Xue, Yaosuo; ...

2017-07-14

Distributed generations (DGs) for grid-connected applications require an accurate and reliable islanding detection methodology (IDM) for secure system operation. This paper presents an IDM for grid-connected inverter-based DGs. The proposed method is a combination of passive and active islanding detection techniques for aggregation of their advantages and elimination/minimisation of the drawbacks. In the proposed IDM, the passive method utilises critical system attributes extracted from local voltage measurements at target DG locations as well as employs decision tree-based classifiers for characterisation and detection of islanding events. The active method is based on Sandia frequency shift technique and is initiated only whenmore » the passive method is unable to differentiate islanding events from other system events. Thus, the power quality degradation introduced into the system by active islanding detection techniques can be minimised. Furthermore, a combination of active and passive techniques allows detection of islanding events under low power mismatch scenarios eliminating the disadvantage associated with the use of passive techniques alone. Finally, detailed case study results demonstrate the effectiveness of the proposed method in detection of islanding events under various power mismatch scenarios, load quality factors and in the presence of single or multiple grid-connected inverter-based DG units.« less

An islanding detection methodology combining decision trees and Sandia frequency shift for inverter-based distributed generations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azim, Riyasat; Li, Fangxing; Xue, Yaosuo

Distributed generations (DGs) for grid-connected applications require an accurate and reliable islanding detection methodology (IDM) for secure system operation. This paper presents an IDM for grid-connected inverter-based DGs. The proposed method is a combination of passive and active islanding detection techniques for aggregation of their advantages and elimination/minimisation of the drawbacks. In the proposed IDM, the passive method utilises critical system attributes extracted from local voltage measurements at target DG locations as well as employs decision tree-based classifiers for characterisation and detection of islanding events. The active method is based on Sandia frequency shift technique and is initiated only whenmore » the passive method is unable to differentiate islanding events from other system events. Thus, the power quality degradation introduced into the system by active islanding detection techniques can be minimised. Furthermore, a combination of active and passive techniques allows detection of islanding events under low power mismatch scenarios eliminating the disadvantage associated with the use of passive techniques alone. Finally, detailed case study results demonstrate the effectiveness of the proposed method in detection of islanding events under various power mismatch scenarios, load quality factors and in the presence of single or multiple grid-connected inverter-based DG units.« less

Faculty as Border Crossers: A Study of Fulbright Faculty

ERIC Educational Resources Information Center

Eddy, Pamela L.

2014-01-01

As adult learners, faculty members approach new experiences based on events of the past, but this underlying framework of understanding is challenged when they work abroad for an extended period of time.

Mining transportation information from social media for planned and unplanned events.

DOT National Transportation Integrated Search

2016-05-01

The objective of this project is on mining social media data to deduce useful travelers information with : a special emphasis under events, including both planned events (such as sporting games), and : unplanned events (such as traffic accidents)....

Fighting detection using interaction energy force

NASA Astrophysics Data System (ADS)

Wateosot, Chonthisa; Suvonvorn, Nikom

2017-02-01

Fighting detection is an important issue in security aimed to prevent criminal or undesirable events in public places. Many researches on computer vision techniques have studied to detect the specific event in crowded scenes. In this paper we focus on fighting detection using social-based Interaction Energy Force (IEF). The method uses low level features without object extraction and tracking. The interaction force is modeled using the magnitude and direction of optical flows. A fighting factor is developed under this model to detect fighting events using thresholding method. An energy map of interaction force is also presented to identify the corresponding events. The evaluation is performed using NUSHGA and BEHAVE datasets. The results show the efficiency with high accuracy regardless of various conditions.

Meta-Analysis of Rare Binary Adverse Event Data

PubMed Central

Bhaumik, Dulal K.; Amatya, Anup; Normand, Sharon-Lise; Greenhouse, Joel; Kaizar, Eloise; Neelon, Brian; Gibbons, Robert D.

2013-01-01

We examine the use of fixed-effects and random-effects moment-based meta-analytic methods for analysis of binary adverse event data. Special attention is paid to the case of rare adverse events which are commonly encountered in routine practice. We study estimation of model parameters and between-study heterogeneity. In addition, we examine traditional approaches to hypothesis testing of the average treatment effect and detection of the heterogeneity of treatment effect across studies. We derive three new methods, simple (unweighted) average treatment effect estimator, a new heterogeneity estimator, and a parametric bootstrapping test for heterogeneity. We then study the statistical properties of both the traditional and new methods via simulation. We find that in general, moment-based estimators of combined treatment effects and heterogeneity are biased and the degree of bias is proportional to the rarity of the event under study. The new methods eliminate much, but not all of this bias. The various estimators and hypothesis testing methods are then compared and contrasted using an example dataset on treatment of stable coronary artery disease. PMID:23734068

GIS-based rare events logistic regression for mineral prospectivity mapping

NASA Astrophysics Data System (ADS)

Xiong, Yihui; Zuo, Renguang

2018-02-01

Mineralization is a special type of singularity event, and can be considered as a rare event, because within a specific study area the number of prospective locations (1s) are considerably fewer than the number of non-prospective locations (0s). In this study, GIS-based rare events logistic regression (RELR) was used to map the mineral prospectivity in the southwestern Fujian Province, China. An odds ratio was used to measure the relative importance of the evidence variables with respect to mineralization. The results suggest that formations, granites, and skarn alterations, followed by faults and aeromagnetic anomaly are the most important indicators for the formation of Fe-related mineralization in the study area. The prediction rate and the area under the curve (AUC) values show that areas with higher probability have a strong spatial relationship with the known mineral deposits. Comparing the results with original logistic regression (OLR) demonstrates that the GIS-based RELR performs better than OLR. The prospectivity map obtained in this study benefits the search for skarn Fe-related mineralization in the study area.

Leaky synapses: Regulation of spontaneous neurotransmission in central synapses

PubMed Central

Wasser, Catherine R.; Kavalali, Ege T.

2009-01-01

The mechanisms underlying spontaneous neurotransmitter release are not well understood. Under physiological as well as pathophysiological circumstances, spontaneous fusion events can set the concentration of ambient levels of neurotransmitter within the synaptic cleft and in the extracellular milieu. In the brain, unregulated release of excitatory neurotransmitters, exacerbated during pathological conditions such as stroke, can lead to neuronal damage and death. In addition, recent findings suggest that under physiological circumstances spontaneous release events can trigger postsynaptic signaling events independent of evoked neurotransmitter release. Therefore, elucidation of mechanisms underlying spontaneous neurotransmission may help us better understand the functional significance of this form of release and provide tools for its selective manipulation. For instance, our recent investigations indicate that the level of cholesterol in the synapse plays a critical role in limiting spontaneous synaptic vesicle fusion. Therefore, alterations in synaptic cholesterol metabolism can be a critical determinant of glutamatergic neurotransmission at rest. This article aims to provide a closer look into our current understanding of the mechanisms underlying spontaneous neurotransmission and the signaling triggered by these unitary release events. PMID:18434032

Does increasing the size of bi-weekly samples of records influence results when using the Global Trigger Tool? An observational study of retrospective record reviews of two different sample sizes.

PubMed

Mevik, Kjersti; Griffin, Frances A; Hansen, Tonje E; Deilkås, Ellen T; Vonen, Barthold

2016-04-25

To investigate the impact of increasing sample of records reviewed bi-weekly with the Global Trigger Tool method to identify adverse events in hospitalised patients. Retrospective observational study. A Norwegian 524-bed general hospital trust. 1920 medical records selected from 1 January to 31 December 2010. Rate, type and severity of adverse events identified in two different samples sizes of records selected as 10 and 70 records, bi-weekly. In the large sample, 1.45 (95% CI 1.07 to 1.97) times more adverse events per 1000 patient days (39.3 adverse events/1000 patient days) were identified than in the small sample (27.2 adverse events/1000 patient days). Hospital-acquired infections were the most common category of adverse events in both the samples, and the distributions of the other categories of adverse events did not differ significantly between the samples. The distribution of severity level of adverse events did not differ between the samples. The findings suggest that while the distribution of categories and severity are not dependent on the sample size, the rate of adverse events is. Further studies are needed to conclude if the optimal sample size may need to be adjusted based on the hospital size in order to detect a more accurate rate of adverse events. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Exceptional Events Submissions Table (2016 Rule)

EPA Pesticide Factsheets

This table contains examples of air agency submitted exceptional events demonstrations and responsive EPA decision documents that have been prepared and/or acted upon under the 2016 Exceptional Events Rule

Attention during memory retrieval enhances future remembering.

PubMed

Dudukovic, Nicole M; Dubrow, Sarah; Wagner, Anthony D

2009-10-01

Memory retrieval is a powerful learning event that influences whether an experience will be remembered in the future. Although retrieval can succeed in the presence of distraction, dividing attention during retrieval may reduce the power of remembering as an encoding event. In the present experiments, participants studied pictures of objects under full attention and then engaged in item recognition and source memory retrieval under full or divided attention. Two days later, a second recognition and source recollection test assessed the impact of attention during initial retrieval on long-term retention. On this latter test, performance was superior for items that had been tested initially under full versus divided attention. More importantly, even when items were correctly recognized on the first test, divided attention reduced the likelihood of subsequent recognition on the second test. The same held true for source recollection. Additionally, foils presented during the first test were also less likely to be later recognized if they had been encountered initially under divided attention. These findings demonstrate that attentive retrieval is critical for learning through remembering.

14 CFR 91.146 - Passenger-carrying flights for the benefit of a charitable, nonprofit, or community event.

Code of Federal Regulations, 2014 CFR

2014-01-01

... benefit of a charitable, nonprofit, or community event. (a) Definitions. For purposes of this section, the following definitions apply: Charitable event means an event that raises funds for the benefit of a... under section 170 of the Internal Revenue Code (26 U.S.C. Section 170). Community event means an event...

14 CFR 91.146 - Passenger-carrying flights for the benefit of a charitable, nonprofit, or community event.

Code of Federal Regulations, 2012 CFR

2012-01-01

... benefit of a charitable, nonprofit, or community event. (a) Definitions. For purposes of this section, the following definitions apply: Charitable event means an event that raises funds for the benefit of a... under section 170 of the Internal Revenue Code (26 U.S.C. Section 170). Community event means an event...

14 CFR 91.146 - Passenger-carrying flights for the benefit of a charitable, nonprofit, or community event.

Code of Federal Regulations, 2013 CFR

2013-01-01

... benefit of a charitable, nonprofit, or community event. (a) Definitions. For purposes of this section, the following definitions apply: Charitable event means an event that raises funds for the benefit of a... under section 170 of the Internal Revenue Code (26 U.S.C. Section 170). Community event means an event...

14 CFR 91.146 - Passenger-carrying flights for the benefit of a charitable, nonprofit, or community event.

Code of Federal Regulations, 2011 CFR

2011-01-01

... benefit of a charitable, nonprofit, or community event. (a) Definitions. For purposes of this section, the following definitions apply: Charitable event means an event that raises funds for the benefit of a... under section 170 of the Internal Revenue Code (26 U.S.C. Section 170). Community event means an event...

Citizen Sensors for SHM: Use of Accelerometer Data from Smartphones

PubMed Central

Feng, Maria; Fukuda, Yoshio; Mizuta, Masato; Ozer, Ekin

2015-01-01

Ubiquitous smartphones have created a significant opportunity to form a low-cost wireless Citizen Sensor network and produce big data for monitoring structural integrity and safety under operational and extreme loads. Such data are particularly useful for rapid assessment of structural damage in a large urban setting after a major event such as an earthquake. This study explores the utilization of smartphone accelerometers for measuring structural vibration, from which structural health and post-event damage can be diagnosed. Widely available smartphones are tested under sinusoidal wave excitations with frequencies in the range relevant to civil engineering structures. Large-scale seismic shaking table tests, observing input ground motion and response of a structural model, are carried out to evaluate the accuracy of smartphone accelerometers under operational, white-noise and earthquake excitations of different intensity. Finally, the smartphone accelerometers are tested on a dynamically loaded bridge. The extensive experiments show satisfactory agreements between the reference and smartphone sensor measurements in both time and frequency domains, demonstrating the capability of the smartphone sensors to measure structural responses ranging from low-amplitude ambient vibration to high-amplitude seismic response. Encouraged by the results of this study, the authors are developing a citizen-engaging and data-analytics crowdsourcing platform towards a smartphone-based Citizen Sensor network for structural health monitoring and post-event damage assessment applications. PMID:25643056

An automatic microseismic or acoustic emission arrival identification scheme with deep recurrent neural networks

NASA Astrophysics Data System (ADS)

Zheng, Jing; Lu, Jiren; Peng, Suping; Jiang, Tianqi

2018-02-01

The conventional arrival pick-up algorithms cannot avoid the manual modification of the parameters for the simultaneous identification of multiple events under different signal-to-noise ratios (SNRs). Therefore, in order to automatically obtain the arrivals of multiple events with high precision under different SNRs, in this study an algorithm was proposed which had the ability to pick up the arrival of microseismic or acoustic emission events based on deep recurrent neural networks. The arrival identification was performed using two important steps, which included a training phase and a testing phase. The training process was mathematically modelled by deep recurrent neural networks using Long Short-Term Memory architecture. During the testing phase, the learned weights were utilized to identify the arrivals through the microseismic/acoustic emission data sets. The data sets were obtained by rock physics experiments of the acoustic emission. In order to obtain the data sets under different SNRs, this study added random noise to the raw experiments' data sets. The results showed that the outcome of the proposed method was able to attain an above 80 per cent hit-rate at SNR 0 dB, and an approximately 70 per cent hit-rate at SNR -5 dB, with an absolute error in 10 sampling points. These results indicated that the proposed method had high selection precision and robustness.

Global Seismic Cross-Correlation Results: Characterizing Repeating Seismic Events

NASA Astrophysics Data System (ADS)

Vieceli, R.; Dodge, D. A.; Walter, W. R.

2016-12-01

Increases in seismic instrument quality and coverage have led to increased knowledge of earthquakes, but have also revealed the complex and diverse nature of earthquake ruptures. Nonetheless, some earthquakes are sufficiently similar to each other that they produce correlated waveforms. Such repeating events have been used to investigate interplate coupling of subduction zones [e.g. Igarashi, 2010; Yu, 2013], study spatio-temporal changes in slip rate at plate boundaries [e.g. Igarashi et al., 2003], observe variations in seismic wave propagation velocities in the crust [e.g. Schaff and Beroza, 2004; Sawazaki et al., 2015], and assess inner core rotation [e.g. Yu, 2016]. The characterization of repeating events on a global scale remains a very challenging problem. An initial global seismic cross-correlation study used over 310 million waveforms from nearly 3.8 million events recorded between 1970 and 2013 to determine an initial look at global correlated seismicity [Dodge and Walter, 2015]. In this work, we analyze the spatial and temporal distribution of the most highly correlated event clusters or "multiplets" from the Dodge and Walter [2015] study. We examine how the distributions and characteristics of multiplets are effected by tectonic environment, source-station separation, and frequency band. Preliminary results suggest that the distribution of multiplets does not correspond to the tectonic environment in any obvious way, nor do they always coincide with the occurrence of large earthquakes. Future work will focus on clustering correlated pairs and working to reduce the bias introduced by non-uniform seismic station coverage and data availability. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Joint pattern of seasonal hydrological droughts and floods alternation in China's Huai River Basin using the multivariate L-moments

NASA Astrophysics Data System (ADS)

Wu, ShaoFei; Zhang, Xiang; She, DunXian

2017-06-01

Under the current condition of climate change, droughts and floods occur more frequently, and events in which flooding occurs after a prolonged drought or a drought occurs after an extreme flood may have a more severe impact on natural systems and human lives. This challenges the traditional approach wherein droughts and floods are considered separately, which may largely underestimate the risk of the disasters. In our study, the sudden alternation of droughts and flood events (ADFEs) between adjacent seasons is studied using the multivariate L-moments theory and the bivariate copula functions in the Huai River Basin (HRB) of China with monthly streamflow data at 32 hydrological stations from 1956 to 2012. The dry and wet conditions are characterized by the standardized streamflow index (SSI) at a 3-month time scale. The results show that: (1) The summer streamflow makes the largest contribution to the annual streamflow, followed by the autumn streamflow and spring streamflow. (2) The entire study area can be divided into five homogeneous sub-regions using the multivariate regional homogeneity test. The generalized logistic distribution (GLO) and log-normal distribution (LN3) are acceptable to be the optimal marginal distributions under most conditions, and the Frank copula is more appropriate for spring-summer and summer-autumn SSI series. Continuous flood events dominate at most sites both in spring-summer and summer-autumn (with an average frequency of 13.78% and 17.06%, respectively), while continuous drought events come second (with an average frequency of 11.27% and 13.79%, respectively). Moreover, seasonal ADFEs most probably occurred near the mainstream of HRB, and drought and flood events are more likely to occur in summer-autumn than in spring-summer.

Reasoning about conjunctive probabilistic concepts in childhood.

PubMed

Fisk, John E; Slattery, Rachel

2005-09-01

While adults are known to exhibit biases when making conjunctive probability judgments, little is known about childhood competencies in this area. Participants (aged between four and five years, eight and ten years, and a group of young adults) attempted to select the more likely of two events, a single event, and a conjunctive event containing, as one of its components, the single event. The problems were such that the objective probabilities of the component events were potentially available. Children in both age groups were generally successful when the single event was likely. However, when it was unlikely, a majority of children rejected it, choosing the conjunctive event instead, thereby committing the conjunction fallacy. A substantial minority of adults also committed the fallacy under equivalent conditions. It is concluded that under certain conditions children are capable of normative conjunctive judgments but that the mechanisms underpinning this capacity remain to be fully understood.

Seismic Characterization of EGS Reservoirs

NASA Astrophysics Data System (ADS)

Templeton, D. C.; Pyle, M. L.; Matzel, E.; Myers, S.; Johannesson, G.

2014-12-01

To aid in the seismic characterization of Engineered Geothermal Systems (EGS), we enhance the traditional microearthquake detection and location methodologies at two EGS systems. We apply the Matched Field Processing (MFP) seismic imaging technique to detect new seismic events using known discrete microearthquake sources. Events identified using MFP are typically smaller magnitude events or events that occur within the coda of a larger event. Additionally, we apply a Bayesian multiple-event seismic location algorithm, called MicroBayesLoc, to estimate the 95% probability ellipsoids for events with high signal-to-noise ratios (SNR). Such probability ellipsoid information can provide evidence for determining if a seismic lineation could be real or simply within the anticipated error range. We apply this methodology to the Basel EGS data set and compare it to another EGS dataset. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Effects of monsoon precipitation variability on the physiological response of two dominant C₄ grasses across a semiarid ecotone.

PubMed

Thomey, Michell L; Collins, Scott L; Friggens, Michael T; Brown, Renee F; Pockman, William T

2014-11-01

For the southwestern United States, climate models project an increase in extreme precipitation events and prolonged dry periods. While most studies emphasize plant functional type response to precipitation variability, it is also important to understand the physiological characteristics of dominant plant species that define plant community composition and, in part, regulate ecosystem response to climate change. We utilized rainout shelters to alter the magnitude and frequency of rainfall and measured the physiological response of the dominant C4 grasses, Bouteloua eriopoda and Bouteloua gracilis. We hypothesized that: (1) the more drought-adapted B. eriopoda would exhibit faster recovery and higher rates of leaf-level photosynthesis (A(net)) than B. gracilis, (2) A(net) would be greater under the higher average soil water content in plots receiving 30-mm rainfall events, (3) co-dominance of B. eriopoda and B. gracilis in the ecotone would lead to intra-specific differences from the performance of each species at the site where it was dominant. Throughout the study, soil moisture explained 40-70% of the variation in A(net). Consequently, differences in rainfall treatments were not evident from intra-specific physiological function without sufficient divergence in soil moisture. Under low frequency, larger rainfall events B. gracilis exhibited improved water status and longer periods of C gain than B. eriopoda. Results from this study indicate that less frequent and larger rainfall events could provide a competitive advantage to B. gracilis and influence species composition across this arid-semiarid grassland ecotone.

Role of multiparton interactions on J /ψ production in p +p collisions at LHC energies

NASA Astrophysics Data System (ADS)

Thakur, Dhananjaya; De, Sudipan; Sahoo, Raghunath; Dansana, Soumya

2018-05-01

The production mechanism of quarkonia states in hadronic collisions is still to be understood by the scientific community. In high-multiplicity p +p collisions, underlying event observables are of major interest. The multiparton interactions (MPIs) are underlying event observables, in which several interactions occur at the partonic level in a single p +p event. This leads to dependence of particle production on event multiplicity. If the MPI occurs in a harder scale, there will be a correlation between the yield of quarkonia and total charged-particle multiplicity. The ALICE experiment at the LHC in p +p collisions at √{s }=7 and 13 TeV has observed an approximate linear increase of relative J /ψ yield, (d/NJ /ψ/d y ⟨d NJ /ψ/d y ⟩ ), with relative charged-particle multiplicity density, (d/Nch/d y ⟨d Nch/d y ⟩ ). In our present work, we have performed a comprehensive study of the production of charmonia as a function of charged-particle multiplicity in p +p collisions at LHC energies using the perturbative QCD-inspired multiparton interaction model, pythia8 tune 4C, with and without the color reconnection scheme. A detailed multiplicity and energy-dependent study is performed to understand the effects of MPI on J /ψ production. The ratio of ψ (2 S ) to J /ψ is also studied as a function of charged-particle multiplicity at LHC energies.

Prolonged warm ischemia time is associated with graft failure and mortality after kidney transplantation.

PubMed

Tennankore, Karthik K; Kim, S Joseph; Alwayn, Ian P J; Kiberd, Bryce A

2016-03-01

Warm ischemia time is a potentially modifiable insult to transplanted kidneys, but little is known about its effect on long-term outcomes. Here we conducted a study of United States kidney transplant recipients (years 2000-2013) to determine the association between warm ischemia time (the time from organ removal from cold storage to reperfusion with warm blood) and death/graft failure. Times under 10 minutes were potentially attributed to coding error. Therefore, the 10-to-under-20-minute interval was chosen as the reference group. The primary outcome was mortality and graft failure (return to chronic dialysis or preemptive retransplantation) adjusted for recipient, donor, immunologic, and surgical factors. The study included 131,677 patients with 35,901 events. Relative to the reference patients, times of 10 to under 20, 20 to under 30, 30 to under 40, 40 to under 50, 50 to under 60, and 60 and more minutes were associated with hazard ratios of 1.07 (95% confidence interval, 0.99-1.15), 1.13 (1.06-1.22), 1.17 (1.09-1.26), 1.20 (1.12-1.30), and 1.23 (1.15-1.33) for the composite event, respectively. Association between prolonged warm ischemia time and death/graft failure persisted after stratification by donor type (living vs. deceased donor) and delayed graft function status. Thus, warm ischemia time is associated with adverse long-term patient and graft survival after kidney transplantation. Identifying strategies to reduce warm ischemia time is an important consideration for future study. Copyright © 2015 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Apportionment of the sources of high fine particulate matter concentration events in a developing aerotropolis in Taoyuan, Taiwan.

PubMed

Chuang, Ming-Tung; Chen, Yu-Chieh; Lee, Chung-Te; Cheng, Chung-Hao; Tsai, Yu-Jen; Chang, Shih-Yu; Su, Zhen-Sen

2016-07-01

To investigate the characteristics and contributions of the sources of fine particulate matter with a size of up to 2.5 μm (PM2.5) during the period when pollution events could easily occur in Taoyuan aerotropolis, Taiwan, this study conducted sampling at three-day intervals from September 2014 to January 2015. Based on the mass concentration of PM2.5, the sampling days were classified into high PM2.5 concentration event days (PM2.5>35 μg m(-3)) and non-event days (PM2.5<35 μg m(-3)). In addition, the chemical species, including water-soluble inorganic ions, carbonaceous components, and metal elements, were analyzed. The sources of pollution and their contributions were estimated using the positive matrix factorization (PMF) model. Furthermore, the effect of the weather type on the measurement results was also explored based on wind field conditions. The mass fractions of Cl(-) and NO3(-) increased when a high PM2.5 concentration event occurred, and they were also higher under local emitted conditions than under long range transported conditions, indicating that secondary nitrate aerosols were the major increasing local species that caused high PM2.5 concentration events. Seven sources of pollution could be distinguished using the PMF model on the basis of the characteristics of the species. Industrial emissions, coal combustion/urban waste incineration, and local emissions from diesel/gasoline vehicles were the main sources that contributed to pollution on high PM2.5 concentration event days. In order to reduction of high PM2.5 concentration events, the control of diesel and gasoline vehicle emission is important and should be given priority. Copyright © 2016 Elsevier Ltd. All rights reserved.

Characterizing Future El Niño Impacts to the Lower Colorado River Basin

NASA Astrophysics Data System (ADS)

Santos, N. I.; Miller, W. P.; Piechota, T. C.; Lakshmi, V.

2015-12-01

Past El Niño events in the Colorado River Basin, such as the 1982-1983 event, resulted in one of the basin's wettest years on record. Looking at past events and the current forecasts, which indicate Pacific Ocean conditions could lead to one of the strongest El Niño events on record this winter, it is no wonder that many water management agencies and their customers are expecting a relief in the southwestern United States (US) drought intensity as the probability of a strong El Niño becomes more significant. Despite the conditions in the Pacific Ocean, a strong El Niño is not a guarantee for wet conditions in the Colorado River basin - as can be seen from the 2002 event in which basin conditions were one of the driest on record. There is a great need to understand the range of possible conditions that could be observed under an El Niño event to better inform southwestern US water management agencies so that they may make well-guided decisions regarding their most valuable resource - the Colorado River. This study builds upon past research based on the Coupled Model Intercomparison Project 5 (CMIP5) climatology and hydrology projections and the analysis performed with singular variable decomposition (SVD) to identify climate models with high correlation between historical climate/hydrology in the CRB and sea surface temperature conditions in the Pacific Ocean. Past research methods were able to identify climate models which performed well using the SVD methodology. This current project seeks to analyze the well-performing climate models and identify future El Niño conditions in the Pacific Ocean and the resultant precipitation and temperature impacts in the lower CRB. This analysis will provide an objective, ensemble based outlook for potential climate change impacts under El Niño events.The results of the study can potentially assist lower CRB water management agencies in characterizing the range of future El Niño impacts, under climate change conditions. It is expected that this information could be beneficial in understanding the range of potential El Niño impacts and their effect on drought in the southwestern US.

Differences in Meteorological Conditions between Days with Persistent and Non-Persistent Pollution in Beijing, China

NASA Astrophysics Data System (ADS)

You, Ting; Wu, Renguang; Huang, Gang

2018-02-01

We compared the regional synoptic patterns and local meteorological conditions during persistent and non-persistent pollution events in Beijing using US NCEP-Department of Energy reanalysis outputs and observations from meteorological stations. The analysis focused on the impacts of high-frequency (period < 90 days) variations in meteorological conditions on persistent pollution events (those lasting for at least 3 days). Persistent pollution events tended to occur in association with slow-moving weather systems producing stagnant weather conditions, whereas rapidly moving weather systems caused a dramatic change in the local weather conditions so that the pollution event was short-lived. Although Beijing was under the influence of anomalous southerly winds in all four seasons during pollution events, notable differences were identified in the regional patterns of sea-level pressure and local anomalies in relative humidity among persistent pollution events in different seasons. A region of lower pressure was present to the north of Beijing in spring, fall, and winter, whereas regions of lower and higher pressures were observed northwest and southeast of Beijing, respectively, in summer. The relative humidity near Beijing was higher in fall and winter, but lower in spring and summer. These differences may explain the seasonal dependence of the relationship between air pollution and the local meteorological variables. Our analysis showed that the temperature inversion in the lower troposphere played an important part in the occurrence of air pollution under stagnant weather conditions. Some results from this study are based on a limited number of events and thus require validation using more data.

Time-linked concurrence of sleep bruxism, periodic limb movements, and EEG arousals in sleep bruxers and healthy controls.

PubMed

van der Zaag, Jacques; Naeije, Machiel; Wicks, Darrel J; Hamburger, Hans L; Lobbezoo, Frank

2014-01-01

Sleep bruxism (SB) and periodic limb movements during sleep (PLMS) may have a common underlying neurophysiologic mechanism, especially in relation to the occurrence of sleep-related electroencephalographic (EEG) arousals. To test this hypothesis, three research questions were assessed. First, it was assessed whether PLMS events occur more frequently in SB patients than in individuals without SB. Second, the question was put forward whether the combined presence of SB and PLMS events is more common than that of isolated SB or PLMS events in a group of SB patients. Third, as to further unravel the possible role of EEG arousals in the underlying neurophysiologic mechanism of SB and PLMS, it was assessed in a group of SB patients whether combined SB/PLMS events with associated EEG arousals are more common than those without associated EEG arousals. Positive answers to these questions could suggest a common neurophysiological basis for both movement disorders. Seventeen SB patients and 11 healthy controls were polysomnographically studied. SB, PLMS, and EEG arousals were scored. An association was noted when the occurrence was within a 3-s association zone. The PLMS index was higher in SB patients than in healthy controls (P < 0.001). Within the group of SB patients, the combined SB/PLMS index was higher than the isolated SB index (P < 0.001) and the isolated PLMS index (P = 0.018). Similarly, the combined SB/PLMS index with EEG arousal was higher than the combined SB/PLMS index without EEG arousal in SB patients (P < 0.001). The results of this study indicate that SB, PLMS, and EEG arousals commonly concur during sleep in a time-linked manner. SB and PLMS probably have a common underlying neurophysiological mechanism.

Rationale, design, and baseline characteristics of a study to evaluate the effect of febuxostat in preventing cerebral, cardiovascular, and renal events in patients with hyperuricemia.

PubMed

Kojima, Sunao; Matsui, Kunihiko; Ogawa, Hisao; Jinnouchi, Hideaki; Hiramitsu, Shinya; Hayashi, Takahiro; Yokota, Naoto; Kawai, Naoki; Tokutake, Eiichi; Uchiyama, Kazuaki; Sugawara, Masahiro; Kakuda, Hirokazu; Wakasa, Yutaka; Mori, Hisao; Hisatome, Ichiro; Waki, Masako; Ohya, Yusuke; Kimura, Kazuo; Saito, Yoshihiko

2017-01-01

Since uric acid is associated with cardiovascular and renal disease, a treatment to maintain blood uric acid level may be required in patients with hyperuricemia. This study aims to evaluate preventive effects of febuxostat, a selective xanthine oxidase inhibitor, on cerebral, cardiovascular, and renal events in patients with hyperuricemia compared to conventional treatment. This study is a prospective randomized open-label blinded endpoint study. Patient enrolment was started in November 2013 and was completed in October 2014. The patients will be followed for at least 3 years. The primary endpoint is a composite of cerebral, cardiovascular, and renal events, and all deaths including death due to cerebral, cardiovascular, and renal disease, new or recurring cerebrovascular disease, new or recurring non-fatal coronary artery disease, cardiac failure requiring hospitalization, arteriosclerotic disease requiring treatment, renal impairment, new atrial fibrillation, and all deaths other than cerebral or cardiovascular or renal disease. These events will be independently evaluated by the Event Assessment Committee under blinded information regarding the treatment group. The study was registered at ClinicalTrials.gov with the identifier NCT01984749. Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Anxiety, depression, suicidal ideation, and stressful life events in non-cardiac adolescent chest pain: a comparative study about the hidden part of the iceberg.

PubMed

Eliacik, Kayi; Kanik, Ali; Bolat, Nurullah; Mertek, Hilal; Guven, Baris; Karadas, Ulas; Dogrusoz, Buket; Bakiler, Ali Rahmi

2017-08-01

Chest pain in adolescents is rarely associated with cardiac disease. Adolescents with medically unexplained chest pain usually have high levels of anxiety and depression. Psychological stress may trigger non-cardiac chest pain. This study evaluated risk factors that particularly characterise adolescence, such as major stressful events, in a clinical population. The present study was conducted on 100 adolescents with non-cardiac chest pain and 76 control subjects. Stressful life events were assessed by interviewing patients using a 36-item checklist, along with the Children's Depression Inventory and Spielberger's State-Trait Anxiety Inventory for children, in both groups. Certain stressful life events, suicidal thoughts, depression, and anxiety were more commonly observed in adolescents with non-cardiac chest pain compared with the control group. Moreover, binary logistic regression analysis showed that trouble with bullies, school-related problems, and depression may trigger non-cardiac chest pain in adolescents. Non-cardiac chest pain on the surface may point to the underlying psychosocial health problems such as depression, suicidal ideas, or important life events such as academic difficulties or trouble with bullies. The need for a psychosocial evaluation that includes assessment of negative life events and a better management have been discussed in light of the results.

Stressful Life Events, Sexual Orientation, and Cardiometabolic Risk Among Young Adults in the United States

PubMed Central

Hatzenbuehler, Mark L.; Slopen, Natalie; McLaughlin, Kate A.

2015-01-01

Objective The goal of the present study was to examine whether sexual minority young adults are more vulnerable to developing cardiometabolic risk following exposure to stressful life events than heterosexual young adults. Method Data came from the National Longitudinal Study for Adolescent Health (Shin, Edwards, & Heeren, 2009; Brummett et al., 2013), a prospective nationally representative study of U.S. adolescents followed into young adulthood. A total of 306 lesbian, gay, and bisexual (LGB) respondents and 6,667 heterosexual respondents met inclusion criteria for this analysis. Measures of cumulative stressful life events were drawn from all 4 waves of data collection; sexual orientation and cardiometabolic biomarkers were assessed at Wave 4 (2008–2009). Results Gay/bisexual men exposed to 1–2 (β = 0.71, p = .01) and 5 + (β = 0.87, p = .01) stressful life events had a statistically significant elevation in cardiometabolic risk, controlling for demographics, health behaviors, and socioeconomic status. Moreover, in models adjusted for all covariates, lesbian/bisexual (β = 0.52, p = .046) women with 5 + stressful life events had a statistically significant elevation in cardiometabolic risk. There was no relationship between stressful life events and cardiometabolic risk among heterosexual men or women. Conclusion Stressful life events during childhood, adolescence, and young adulthood place LGB young adults at heightened risk for elevated cardiometabolic risk as early as young adulthood. The mechanisms underlying this relationship require future study. PMID:25133830

Prescription-event monitoring: developments in signal detection.

PubMed

Ferreira, Germano

2007-01-01

Prescription-event monitoring (PEM) is a non-interventional intensive method for post-marketing drug safety monitoring of newly licensed medicines. PEM studies are cohort studies where exposure is obtained from a centralised service and outcomes from simple questionnaires completed by general practitioners. Follow-up forms are sent for selected events. Because PEM captures all events and not only the suspected adverse drug reactions, PEM cohorts potentially differ in respect to the distribution of number of events per person depending on the nature of the drug under study. This variance can be related either with the condition for which the drug is prescribed (e.g. a condition causing high morbidity will have, in average, a higher number of events per person compared with a condition with lower morbidity) or with the drug effect itself. This paper describes an exploratory investigation of the distortion caused by product-related variations of the number of events to the interpretation of the proportional reporting ratio (PRR) values ("the higher the PRR, the greater the strength of the signal") computed using drug-cohort data. We studied this effect by assessing the agreement between the PRR based on events (event of interest vs all other events) and PRR based on cases (cases with the event of interest vs cases with any other events). PRR were calculated for all combinations reported to ten selected drugs against a comparator of 81 other drugs. Three of the ten drugs had a cohort with an apparent higher proportion of patients with lower number of events. The PRRs based on events were systematically higher than the PRR based on cases for the combinations reported to these three drugs. Additionally, when applying the threshold criteria for signal screening (n > or =3, PRR > or =1.5 and Chi-squared > or =4), the binary agreement was generally high but apparently lower for these three drugs. In conclusion, the distribution of events per patient in drug cohorts shall be examined when comparing the 'strength of the signals' across drugs using PRR values. Further research will be required to address the sensitivity and specificity of the two ways of calculating PRR using data derived from drug cohorts.

The effectiveness of airline pilot training for abnormal events.

PubMed

Casner, Stephen M; Geven, Richard W; Williams, Kent T

2013-06-01

To evaluate the effectiveness of airline pilot training for abnormal in-flight events. Numerous accident reports describe situations in which pilots responded to abnormal events in ways that were different from what they had practiced many times before. One explanation for these missteps is that training and testing for these skills have become a highly predictable routine for pilots who arrive to the training environment well aware of what to expect. Under these circumstances, pilots get plentiful practice in responding to abnormal events but may get little practice in recognizing them and deciding which responses to offer. We presented 18 airline pilots with three abnormal events that are required during periodic training and testing. Pilots were presented with each event under the familiar circumstances used during training and also under less predictable circumstances as they might occur during flight. When presented in the routine ways seen during training, pilots gave appropriate responses and showed little variability. However, when the abnormal events were presented unexpectedly, pilots' responses were less appropriate and showed great variability from pilot to pilot. The results suggest that the training and testing practices used in airline training may result in rote-memorized skills that are specific to the training situation and that offer modest generalizability to other situations. We recommend a more complete treatment of abnormal events that allows pilots to practice recognizing the event and choosing and recalling the appropriate response. The results will aid the improvement of existing airline training practices.

Understanding Uncertainties and Biases in Jet Quenching in High-Energy Nucleus-Nucleus Collisions

NASA Astrophysics Data System (ADS)

Heinz, Matthias

2017-09-01

Jets are the collimated streams of particles resulting from hard scattering in the initial state of high-energy collisions. In heavy-ion collisions, jets interact with the quark-gluon plasma (QGP) before freezeout, providing a probe into the internal structure and properties of the QGP. In order to study jets, background must be subtracted from the measured event, potentially introducing a bias. We aim to understand quantify this subtraction bias. PYTHIA, a library to simulate pure jet events, is used to simulate a model for a signature with one pure jet (a photon) and one quenched jet, where all quenched particle momenta are reduced by the same fraction. Background for the event is simulated using multiplicity values generated by the TRENTO initial state model of heavy-ion collisions fed into a thermal model from which to sample particle types and a 3-dimensional Boltzmann distribution from which to sample particle momenta. Data from the simulated events is used to train a statistical model, which computes a posterior distribution of the quench factor for a data set. The model was tested first on pure jet events and later on full events including the background. This model will allow for a quantitative determination of biases induced by various methods of background subtraction. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Reliability of Memories Protected by Multibit Error Correction Codes Against MBUs

NASA Astrophysics Data System (ADS)

Ming, Zhu; Yi, Xiao Li; Chang, Liu; Wei, Zhang Jian

2011-02-01

As technology scales, more and more memory cells can be placed in a die. Therefore, the probability that a single event induces multiple bit upsets (MBUs) in adjacent memory cells gets greater. Generally, multibit error correction codes (MECCs) are effective approaches to mitigate MBUs in memories. In order to evaluate the robustness of protected memories, reliability models have been widely studied nowadays. Instead of irradiation experiments, the models can be used to quickly evaluate the reliability of memories in the early design. To build an accurate model, some situations should be considered. Firstly, when MBUs are presented in memories, the errors induced by several events may overlap each other, which is more frequent than single event upset (SEU) case. Furthermore, radiation experiments show that the probability of MBUs strongly depends on angles of the radiation event. However, reliability models which consider the overlap of multiple bit errors and angles of radiation event have not been proposed in the present literature. In this paper, a more accurate model of memories with MECCs is presented. Both the overlap of multiple bit errors and angles of event are considered in the model, which produces a more precise analysis in the calculation of mean time to failure (MTTF) for memory systems under MBUs. In addition, memories with scrubbing and nonscrubbing are analyzed in the proposed model. Finally, we evaluate the reliability of memories under MBUs in Matlab. The simulation results verify the validity of the proposed model.

Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.

PubMed

Baxi, Shrujal; Yang, Annie; Gennarelli, Renee L; Khan, Niloufer; Wang, Ziwei; Boyce, Lindsay; Korenstein, Deborah

2018-03-14

To evaluate rates of serious organ specific immune-related adverse events, general adverse events related to immune activation, and adverse events consistent with musculoskeletal problems for anti-programmed cell death 1 (PD-1) drugs overall and compared with control treatments. Systematic review and meta-analysis. Medline, Embase, Cochrane Library, Web of Science, and Scopus searched to 16 March 2017 and combined with data from ClinicalTrials.gov. Eligible studies included primary clinical trial data on patients with cancer with recurrent or metastatic disease. Three independent investigators extracted data on adverse events from ClinicalTrials.gov and the published studies. Risk of bias was assessed using the Cochrane tool by three independent investigators. 13 relevant studies were included; adverse event data were available on ClinicalTrials.gov for eight. Studies compared nivolumab (n=6), pembrolizumab (5), or atezolizumab (2) with chemotherapy (11), targeted drugs (1), or both (1). Serious organ specific immune-related adverse events were rare, but compared with standard treatment, rates of hypothyroidism (odds ratio 7.56, 95% confidence interval 4.53 to 12.61), pneumonitis (5.37, 2.73 to 10.56), colitis (2.88, 1.30 to 6.37), and hypophysitis (3.38, 1.02 to 11.08) were increased with anti-PD-1 drugs. Of the general adverse events related to immune activation, only the rate of rash (2.34, 2.73 to 10.56) increased. Incidence of fatigue (32%) and diarrhea (19%) were high but similar to control. Reporting of adverse events consistent with musculoskeletal problems was inconsistent; rates varied but were over 20% in some studies for arthraligia and back pain. Organ specific immune-related adverse events are uncommon with anti-PD-1 drugs but the risk is increased compared with control treatments. General adverse events related to immune activation are largely similar. Adverse events consistent with musculoskeletal problems are inconsistently reported but adverse events may be common. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Brain Correlates of Phasic Autonomic Response to Acupuncture Stimulation: An Event-Related fMRI Study

PubMed Central

Napadow, Vitaly; Lee, Jeungchan; Kim, Jieun; Cina, Stephen; Maeda, Yumi; Barbieri, Riccardo; Harris, Richard E.; Kettner, Norman; Park, Kyungmo

2013-01-01

Autonomic nervous system (ANS) response to acupuncture has been investigated by multiple studies; however, the brain circuitry underlying this response is not well understood. We applied event-related fMRI (er-fMRI) in conjunction with ANS recording (heart rate, HR; skin conductance response, SCR). Brief manual acupuncture stimuli were delivered at acupoints ST36 and SP9, while sham stimuli were delivered at control location, SH1. Acupuncture produced activation in S2, insula, and mid-cingulate cortex, and deactivation in default mode network (DMN) areas. On average, HR deceleration (HR–) and SCR were noted following both real and sham acupuncture, though magnitude of response was greater following real acupuncture and inter-subject magnitude of response correlated with evoked sensation intensity. Acupuncture events with strong SCR also produced greater anterior insula activation than without SCR. Moreover, acupuncture at SP9, which produced greater SCR, also produced stronger sharp pain sensation, and greater anterior insula activation. Conversely, acupuncture-induced HR– was associated with greater DMN deactivation. Between-event correlation demonstrated that this association was strongest for ST36, which also produced more robust HR–. In fact, DMN deactivation was significantly more pronounced across acupuncture stimuli producing HR–, versus those events characterized by acceleration (HR+). Thus, differential brain response underlying acupuncture stimuli may be related to differential autonomic outflows and may result from heterogeneity in evoked sensations. Our er-fMRI approach suggests that ANS response to acupuncture, consistent with previously characterized orienting and startle/defense responses, arises from activity within distinct subregions of the more general brain circuitry responding to acupuncture stimuli. PMID:22504841

General practitioners' attitudes toward reporting and learning from adverse events: results from a survey.

PubMed

Mikkelsen, Thorbjørn H; Sokolowski, Ineta; Olesen, Frede

2006-03-01

To investigate GPs' attitudes to and willingness to report and learn from adverse events and to study how a reporting system should function. Survey. General practice in Denmark. GPs' attitudes to exchange of experience with colleagues and others, and circumstances under which such exchange is accepted. A structured questionnaire sent to 1198 GPs of whom 61% responded. RESULTS. GPs had a positive attitude towards discussing adverse events in the clinic with colleagues and staff and in their continuing medical education groups. The GPs had a positive attitude to reporting adverse events to a database if the system granted legal and administrative immunity to reporters. The majority preferred a reporting system located at a research institute. GPs have a very positive attitude towards discussing and reporting adverse events. This project encourages further research and pilot projects testing concrete reporting systems.

Producing physically consistent and bias free extreme precipitation events over the Switzerland: Bridging gaps between meteorology and impact models

NASA Astrophysics Data System (ADS)

José Gómez-Navarro, Juan; Raible, Christoph C.; Blumer, Sandro; Martius, Olivia; Felder, Guido

2016-04-01

Extreme precipitation episodes, although rare, are natural phenomena that can threat human activities, especially in areas densely populated such as Switzerland. Their relevance demands the design of public policies that protect public assets and private property. Therefore, increasing the current understanding of such exceptional situations is required, i.e. the climatic characterisation of their triggering circumstances, severity, frequency, and spatial distribution. Such increased knowledge shall eventually lead us to produce more reliable projections about the behaviour of these events under ongoing climate change. Unfortunately, the study of extreme situations is hampered by the short instrumental record, which precludes a proper characterization of events with return period exceeding few decades. This study proposes a new approach that allows studying storms based on a synthetic, but physically consistent database of weather situations obtained from a long climate simulation. Our starting point is a 500-yr control simulation carried out with the Community Earth System Model (CESM). In a second step, this dataset is dynamically downscaled with the Weather Research and Forecasting model (WRF) to a final resolution of 2 km over the Alpine area. However, downscaling the full CESM simulation at such high resolution is infeasible nowadays. Hence, a number of case studies are previously selected. This selection is carried out examining the precipitation averaged in an area encompassing Switzerland in the ESM. Using a hydrological criterion, precipitation is accumulated in several temporal windows: 1 day, 2 days, 3 days, 5 days and 10 days. The 4 most extreme events in each category and season are selected, leading to a total of 336 days to be simulated. The simulated events are affected by systematic biases that have to be accounted before this data set can be used as input in hydrological models. Thus, quantile mapping is used to remove such biases. For this task, a 20-yr high-resolution control simulation is carried out. The extreme events belong to this distribution, and can be mapped onto the distribution of precipitation obtained from a gridded product of precipitation provided by MeteoSwiss. This procedure yields bias-free extreme precipitation events which serve as input by hydrological models that eventually produce a simulated, yet physically consistent flooding event. Thereby, the proposed methodology guarantees consistency with the underlying physics of extreme events, and reproduces plausible impacts of up to one-in-five-centuries situations.

Evaluation of Probable Maximum Precipitation and Flood under Climate Change in the 21st Century

NASA Astrophysics Data System (ADS)

Gangrade, S.; Kao, S. C.; Rastogi, D.; Ashfaq, M.; Naz, B. S.; Kabela, E.; Anantharaj, V. G.; Singh, N.; Preston, B. L.; Mei, R.

2016-12-01

Critical infrastructures are potentially vulnerable to extreme hydro-climatic events. Under a warming environment, the magnitude and frequency of extreme precipitation and flood are likely to increase enhancing the needs to more accurately quantify the risks due to climate change. In this study, we utilized an integrated modeling framework that includes the Weather Research Forecasting (WRF) model and a high resolution distributed hydrology soil vegetation model (DHSVM) to simulate probable maximum precipitation (PMP) and flood (PMF) events over Alabama-Coosa-Tallapoosa River Basin. A total of 120 storms were selected to simulate moisture maximized PMP under different meteorological forcings, including historical storms driven by Climate Forecast System Reanalysis (CFSR) and baseline (1981-2010), near term future (2021-2050) and long term future (2071-2100) storms driven by Community Climate System Model version 4 (CCSM4) under Representative Concentrations Pathway 8.5 emission scenario. We also analyzed the sensitivity of PMF to various antecedent hydrologic conditions such as initial soil moisture conditions and tested different compulsive approaches. Overall, a statistical significant increase is projected for future PMP and PMF, mainly attributed to the increase of background air temperature. The ensemble of simulated PMP and PMF along with their sensitivity allows us to better quantify the potential risks associated with hydro-climatic extreme events on critical energy-water infrastructures such as major hydropower dams and nuclear power plants.

A Regional-Scale Evaluation on Environmental Stability Conditions for Convective Rain under Climate Change from Super-High-Resolution GCM Simulations

NASA Astrophysics Data System (ADS)

Takemi, T.; Nomura, S.; Oku, Y.; Ishikawa, H.

2011-12-01

Understanding and forecasting of convective rain due to intense thunderstorms, which develop under conditions both with and without significant synoptic-scale and/or mesoscale forcings, are critical in dealing with disaster prevention/mitigation and developing urban planning appropriate for disaster management. Thunderstorms rapidly develop even during the daytimes of fair weather conditions without any external forcings, and sometimes become strong enough to induce local-scale meteorological disasters such as torrential rain, flush flooding, high winds, and tornadoes/gusts. With the growing interests in climate change, future changes in the behavior of such convectively generated extreme events have gained scientific and societal interests. This study conducted the regional-scale evaluations on the environmental stability conditions for convective rain that develops under synoptically undisturbed, summertime conditions by using the outputs of super-high-resolution AGCM simulations, at a 20-km resolution, for the present, the near-future, and the future climates under global warming with IPCC A1B emission scenario. The GCM, MRI-AGCM3.2S, was developed by Meteorological Research Institute of Japan Meteorological Agency under the KAKUSHIN program funded by the Ministry of Education, Culture, Sports, Science, and Technology of Japan. The climate simulation outputs that were used in this study corresponded to three 25-year periods: 1980-2004 for the present climate; 2020-2044 for the near-future climate; and 2075-2099 for the future climate. The Kanto Plain that includes the Tokyo metropolitan area was chosen as the study area, since the Tokyo metropolitan area is one of the largest metropolises in the world and is vulnerable to extreme weather events. Therefore, one of the purposes of this study was to examine how regional-scale evaluations are performed from the super-high-resolution GCM outputs. After verifying the usefulness of the GCM present-climate outputs with observations and operational mesoscale analyses, we examined, as another purpose of this study, the future changes in the environmental stability for convective rain. To diagnose the environmental conditions, some of the commonly used stability parameters and indices were examined. In the future climates, temperature lapse rate decreased in the lower troposphere, while water vapor mixing ratio increased throughout the deep troposphere. The changes in the temperature and moisture profiles resulted in the increase in both precipitable water vapor and convective available potential energy. These projected changes will be enhanced with the future period. Furthermore, the statistical analyses for the differences of the stability parameters between no-rain and rain days under the synoptically undisturbed condition in each simulated climate period indicated that the environmental conditions in terms of the stability parameters that distinguish no-rain and rain events are basically unchanged between the present and the future climates. This result suggests that the environmental characteristics favorable for afternoon rain events in the synoptically undisturbed environments will not change under global warming.

Characteristics of extreme dust events observed over two urban areas in Iran

NASA Astrophysics Data System (ADS)

Bidokhti, Abbas-Ali A.; Gharaylou, Maryam; Pegahfar, Nafiseh; Sabetghadam, Samaneh; Rezazadeh, Maryam

2016-03-01

Determination of dust loading in the atmosphere is important not only from the public health point of view, but also for regional climate changes. The present study focuses on the characteristics of two major dust events for two urban areas in Iran, Kermanshah and Tehran, over the period of 4 years from 2006 to 2009. To detect extreme dust outbreaks, various datasets including synoptic data, dust concentration, reanalysis data and numerical results of WRF and HYSPLIT models were used. The weather maps demonstrate that for these events dusts are mainly generated when wind velocity is high and humidity is low in the lower troposphere and the region is under the influence of a thermal low. The event lasts until the atmospheric stability prevails and the surface wind speed weakens. The thermal low nature of the synoptic conditions of these major events is also responsible for deep boundary layer development with its thermals affecting the vertical dust flux over the region. Trajectory studies show that the dust events originated from deserts in Iraq and Syria and transported towards Iran. The main distinction between the two types of mobilizations seems to affect the dust concentrations in the Tehran urban area.

The Neural Representations Underlying Human Episodic Memory.

PubMed

Xue, Gui

2018-06-01

A fundamental question of human episodic memory concerns the cognitive and neural representations and processes that give rise to the neural signals of memory. By integrating behavioral tests, formal computational models, and neural measures of brain activity patterns, recent studies suggest that memory signals not only depend on the neural processes and representations during encoding and retrieval, but also on the interaction between encoding and retrieval (e.g., transfer-appropriate processing), as well as on the interaction between the tested events and all other events in the episodic memory space (e.g., global matching). In addition, memory signals are also influenced by the compatibility of the event with the existing long-term knowledge (e.g., schema matching). These studies highlight the interactive nature of human episodic memory. Copyright © 2018 Elsevier Ltd. All rights reserved.

Early/fast VLF events produced by the quiescent heating of the lower ionosphere by thunderstorms

NASA Astrophysics Data System (ADS)

Kabirzadeh, R.; Marshall, R. A.; Inan, U. S.

2017-06-01

Large and easily distinguishable perturbations of the VLF transmitter signals due to interactions with thundercloud-driven ionospheric modifications have been observed and studied for about three decades. These events are called "early/fast VLF" or "early VLF" events due to their immediate detection (˜20 ms) after the causative lightning flash on the ground and the fast rise time of the perturbed signal. Despite many years of study, the physical mechanisms responsible for these perturbations are still under investigation. Modifications of the sustained heating level of the ionosphere due to a lightning flash has been previously proposed as the causative mechanism of early/fast VLF events. The perturbations predicted by this mechanism, however, have been much smaller than experimental observations of 0.2-1 dB or higher. In this study, by using an improved 3-D thundercloud electrostatic upward coupling model which uses a realistic geomagnetic field, we find that the sustained heating model can predict perturbations that are consistent with reported experimental observations. Modifications in the quiescent heating of the lower ionosphere by thundercloud fields by individual lightning flashes may thus account for some observations of early/fast VLF events.

Evaluation of adverse drug event information in US manufacturer labels.

PubMed

Harrington, Catherine A; Garcia, Angela S; Sircar-Ramsewak, Feroza

2011-02-01

Pharmaceutical manufacturer labels are an important source of adverse drug event (ADE) information. The study objective was to determine the sufficiency of ADE reporting in US drug labels. A sample of 50 labels was evaluated from the top 200 drugs dispensed in the US. Electronic copies of labels were obtained and reviewed by 2 pharmacists for ADE incidence and discontinuation data. ADE incidence data were provided in 86% of labels. However, discontinuation rates due to ADEs and ADE incidence by dose were only reported in 60%. ADE incidence reporting by age (46%) or gender (18%) was also low. ADEs that occurred in less than 2% of the population were rarely reported. Incidence rates were based on small populations (median of 794) and short term studies (median of 84 days for chronic conditions). Labels for 19 drugs used chronically had no long term study data. Methods for collecting ADE data were stated in only 12% of labels. Adverse drug event and drug discontinuation data is under-reported in US labels. More information on adverse events causing discontinuation (especially serious events) and those related to dose, age, and gender is needed in labels to ensure safe prescribing and dispensing of drugs.

Microfluidics and Coagulation Biology

PubMed Central

Colace, Thomas V.; Tormoen, Garth W.

2014-01-01

The study of blood ex vivo can occur in closed or open systems, with or without flow. Microfluidic devices facilitate measurements of platelet function, coagulation biology, cellular biorheology, adhesion dynamics, pharmacology, and clinical diagnostics. An experimental session can accommodate 100s to 1000s of unique clotting events. Using microfluidics, thrombotic events can be studied on defined surfaces of biopolymers, matrix proteins, and tissue factor under constant flow rate or constant pressure drop conditions. Distinct shear rates can be created on a device with a single perfusion pump. Microfluidic devices facilitated the determination of intraluminal thrombus permeability and the discovery that platelet contractility can be activated by a sudden decrease in flow. Microfluidics are ideal for multicolor imaging of platelets, fibrin, and phosphatidylserine and provide a human blood analog to the mouse injury models. Overall, microfluidic advances offer many opportunities for research, drug testing under relevant hemodynamic conditions, and clinical diagnostics. PMID:23642241

Integration of UAV photogrammetry and SPH modelling of fluids to study runoff on real terrains.

PubMed

Barreiro, Anxo; Domínguez, Jose M; C Crespo, Alejandro J; González-Jorge, Higinio; Roca, David; Gómez-Gesteira, Moncho

2014-01-01

Roads can experience runoff problems due to the intense rain discharge associated to severe storms. Two advanced tools are combined to analyse the interaction of complex water flows with real terrains. UAV (Unmanned Aerial Vehicle) photogrammetry is employed to obtain accurate topographic information on small areas, typically on the order of a few hectares. The Smoothed Particle Hydrodynamics (SPH) technique is applied by means of the DualSPHysics model to compute the trajectory of the water flow during extreme rain events. The use of engineering solutions to palliate flood events is also analysed. The study case simulates how the collected water can flow into a close road and how precautionary measures can be effective to drain water under extreme conditions. The amount of water arriving at the road is calculated under different protection scenarios and the efficiency of a ditch is observed to decrease when sedimentation reduces its depth.

Integration of UAV Photogrammetry and SPH Modelling of Fluids to Study Runoff on Real Terrains

PubMed Central

Barreiro, Anxo; Domínguez, Jose M.; C. Crespo, Alejandro J.; González-Jorge, Higinio; Roca, David; Gómez-Gesteira, Moncho

2014-01-01

Roads can experience runoff problems due to the intense rain discharge associated to severe storms. Two advanced tools are combined to analyse the interaction of complex water flows with real terrains. UAV (Unmanned Aerial Vehicle) photogrammetry is employed to obtain accurate topographic information on small areas, typically on the order of a few hectares. The Smoothed Particle Hydrodynamics (SPH) technique is applied by means of the DualSPHysics model to compute the trajectory of the water flow during extreme rain events. The use of engineering solutions to palliate flood events is also analysed. The study case simulates how the collected water can flow into a close road and how precautionary measures can be effective to drain water under extreme conditions. The amount of water arriving at the road is calculated under different protection scenarios and the efficiency of a ditch is observed to decrease when sedimentation reduces its depth. PMID:25372035

Perceiving goals and actions in individuals with autism spectrum disorders.

PubMed

Zalla, Tiziana; Labruyère, Nelly; Georgieff, Nicolas

2013-10-01

In the present study, we investigated the ability to parse familiar sequences of action into meaningful events in young individuals with autism spectrum disorders (ASDs), as compared to young individuals with typical development (TD) and young individuals with moderate mental retardation or learning disabilities (MLDs). While viewing two videotaped movies, participants were requested to detect the boundary transitions between component events at both fine and coarse levels of the action hierarchical structure. Overall, reduced accuracy for event detection was found in participants with ASDs, relative to participants with TD, at both levels of action segmentation. The performance was, however, equally diminished in participants with ASDs and MLDs under the course-grained segmentation suggesting that difficulties to detect fine-grained events in ASDs cannot be explained by a general intellectual dysfunction. Reduced accuracy for event detection was related to diminished event recall, memory for event sequence and Theory of Mind abilities. We hypothesized that difficulties with event detection result from a deficit disrupting the on-line processing of kinematic features and physical changes of dynamic human actions. An impairment at the earlier stages of the event encoding process might contribute to deficits in episodic memory and social functioning in individuals with ASDs.

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains.

PubMed

Wang, Chong; Long, Wenying; Peng, Chao; Hu, Lin; Zhang, Qiong; Wu, Ailing; Zhang, Xiaoqing; Duan, Xiaotao; Wong, Catherine C L; Tanaka, Yuetsu; Xia, Zongping

2016-04-01

The HTLV-1 oncoprotein Tax plays a key role in CD4+ T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in understanding HTLV-1-mediated transformation. Current studies have suggested multiple but controversial mechanisms regarding Tax-induced IKK activation mainly due to blending of primary Tax-induced IKK activation events and secondary IKK activation events induced by cytokines secreted by the primary Tax-induced IKK-NF-κB activation events. We reconstituted Tax-stimulated IKK activation in a cell-free system to dissect the essential cellular components for primary IKK activation by Tax and studied the underlying biochemical mechanism. We found that Tax is a putative E3 ubiquitin ligase, which, together with UbcH2, UhcH5c, or UbcH7, catalyzes the assembly of free mixed-linkage polyubiquitin chains. These free mixed-linkage polyubiquitin chains are then responsible for direct IKK activation by binding to the NEMO subunit of IKK. Our studies revealed the biochemical function of Tax in the process of IKK activation, which utilizes the minimal cellular ubiquitination components for NF-κB activation.

HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains

PubMed Central

Wang, Chong; Long, Wenying; Peng, Chao; Hu, Lin; Zhang, Qiong; Wu, Ailing; Zhang, Xiaoqing; Duan, Xiaotao; Wong, Catherine C. L.; Tanaka, Yuetsu; Xia, Zongping

2016-01-01

The HTLV-1 oncoprotein Tax plays a key role in CD4+ T cell transformation by promoting cell proliferation and survival, mainly through permanent activation of the NK-κB pathway and induction of many NF-κB target genes. Elucidating the underlying molecular mechanism is therefore critical in understanding HTLV-1-mediated transformation. Current studies have suggested multiple but controversial mechanisms regarding Tax-induced IKK activation mainly due to blending of primary Tax-induced IKK activation events and secondary IKK activation events induced by cytokines secreted by the primary Tax-induced IKK-NF-κB activation events. We reconstituted Tax-stimulated IKK activation in a cell-free system to dissect the essential cellular components for primary IKK activation by Tax and studied the underlying biochemical mechanism. We found that Tax is a putative E3 ubiquitin ligase, which, together with UbcH2, UhcH5c, or UbcH7, catalyzes the assembly of free mixed-linkage polyubiquitin chains. These free mixed-linkage polyubiquitin chains are then responsible for direct IKK activation by binding to the NEMO subunit of IKK. Our studies revealed the biochemical function of Tax in the process of IKK activation, which utilizes the minimal cellular ubiquitination components for NF-κB activation. PMID:27082114

Episodic and semantic content of memory and imagination: A multilevel analysis.

PubMed

Devitt, Aleea L; Addis, Donna Rose; Schacter, Daniel L

2017-10-01

Autobiographical memories of past events and imaginations of future scenarios comprise both episodic and semantic content. Correlating the amount of "internal" (episodic) and "external" (semantic) details generated when describing autobiographical events can illuminate the relationship between the processes supporting these constructs. Yet previous studies performing such correlations were limited by aggregating data across all events generated by an individual, potentially obscuring the underlying relationship within the events themselves. In the current article, we reanalyzed datasets from eight studies using a multilevel approach, allowing us to explore the relationship between internal and external details within events. We also examined whether this relationship changes with healthy aging. Our reanalyses demonstrated a largely negative relationship between the internal and external details produced when describing autobiographical memories and future imaginations. This negative relationship was stronger and more consistent for older adults and was evident both in direct and indirect measures of semantic content. Moreover, this relationship appears to be specific to episodic tasks, as no relationship was observed for a nonepisodic picture description task. This negative association suggests that people do not generate semantic information indiscriminately, but do so in a compensatory manner, to embellish episodically impoverished events. Our reanalysis further lends support for dissociable processes underpinning episodic and semantic information generation when remembering and imagining autobiographical events.

On the estimation of intracluster correlation for time-to-event outcomes in cluster randomized trials.

PubMed

Kalia, Sumeet; Klar, Neil; Donner, Allan

2016-12-30

Cluster randomized trials (CRTs) involve the random assignment of intact social units rather than independent subjects to intervention groups. Time-to-event outcomes often are endpoints in CRTs. Analyses of such data need to account for the correlation among cluster members. The intracluster correlation coefficient (ICC) is used to assess the similarity among binary and continuous outcomes that belong to the same cluster. However, estimating the ICC in CRTs with time-to-event outcomes is a challenge because of the presence of censored observations. The literature suggests that the ICC may be estimated using either censoring indicators or observed event times. A simulation study explores the effect of administrative censoring on estimating the ICC. Results show that ICC estimators derived from censoring indicators or observed event times are negatively biased. Analytic work further supports these results. Observed event times are preferred to estimate the ICC under minimum frequency of administrative censoring. To our knowledge, the existing literature provides no practical guidance on the estimation of ICC when substantial amount of administrative censoring is present. The results from this study corroborate the need for further methodological research on estimating the ICC for correlated time-to-event outcomes. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice.

PubMed

Lanas, Angel; Boers, Maarten; Nuevo, Javier

2015-04-01

Data concerning rates of gastrointestinal (GI) events in non-steroidal anti-inflammatory drug (NSAID) users derive mainly from clinical trials. The EVIDENCE study quantified the incidence of symptomatic uncomplicated and/or complicated GI events in at-risk European patients treated with NSAIDs in real-life practice. This non-interventional study assessed 4144 adults with at least one GI risk factor who recently initiated NSAID therapy for osteoarthritis (85%), rheumatoid arthritis (11%), ankylosing spondylitis (3%) or a combination (1%). Patient characteristics and medical history were collected from medical records. GI events (upper and lower) were recorded at in-clinic visits during 6 months' follow-up. Mean time on index NSAID at enrolment was 33 days. The incidence (per 100 person-years) was 18.5 per 100 person-years for uncomplicated GI events and 0.7 per 100 person-years for complicated GI events. Upper GI events were far more common (12%) than lower GI events (1%) during study follow-up (median 182 days (range 61-320)). Other reported rates for cardiovascular, anaemia or non-GI events were much less frequent. A minority (28%) of patients had ongoing proton pump inhibitor use at enrolment, with strong variation by practice and country. EVIDENCE is the largest prospective study of the real-life management of European patients treated with NSAIDs for rheumatic diseases and at increased GI risk. It shows that GI events from the upper GI tract are far more common than those from the lower GI tract. It also shows adherence to guidelines for gastroprotection is generally low. NCT01176682. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Soft Water Level Sensors for Characterizing the Hydrological Behaviour of Agricultural Catchments

PubMed Central

Crabit, Armand; Colin, François; Bailly, Jean Stéphane; Ayroles, Hervé; Garnier, François

2011-01-01

An innovative soft water level sensor is proposed to characterize the hydrological behaviour of agricultural catchments by measuring rainfall and stream flows. This sensor works as a capacitor coupled with a capacitance to frequency converter and measures water level at an adjustable time step acquisition. It was designed to be handy, minimally invasive and optimized in terms of energy consumption and low-cost fabrication so as to multiply its use on several catchments under natural conditions. It was used as a stage recorder to measure water level dynamics in a channel during a runoff event and as a rain gauge to measure rainfall amount and intensity. Based on the Manning equation, a method allowed estimation of water discharge with a given uncertainty and hence runoff volume at an event or annual scale. The sensor was tested under controlled conditions in the laboratory and under real conditions in the field. Comparisons of the sensor to reference devices (tipping bucket rain gauge, hydrostatic pressure transmitter limnimeter, Venturi channels…) showed accurate results: rainfall intensities and dynamic responses were accurately reproduced and discharges were estimated with an uncertainty usually acceptable in hydrology. Hence, it was used to monitor eleven small agricultural catchments located in the Mediterranean region. Both catchment reactivity and water budget have been calculated. Dynamic response of the catchments has been studied at the event scale through the rising time determination and at the annual scale by calculating the frequency of occurrence of runoff events. It provided significant insight into catchment hydrological behaviour which could be useful for agricultural management perspectives involving pollutant transport, flooding event and global water balance. PMID:22163868

Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors.

PubMed

Eberwein, Philipp; Laird, Dougal; Schulz, Simon; Reinhard, Thomas; Steinberg, Thorsten; Tomakidi, Pascal

2015-10-01

Within the concept of integrin growth factor receptor (GFR) cross-talk, little is known about the effects of GFRs on focal adhesions (FAs). Therefore, we tested the hypothesis whether EGF can modulate constituents of FAs and subsequent down-stream events. To this end, EGF-treated keratinocytes were subjected to combined fluorescence imaging and western blotting, to quantify expression and/or activation of molecules, involved in integrin GFR cross-talk, and receptor proximal and distal signaling events. Generally, EGF response revealed an amplified redistribution or activation of molecules under study, which will be explained in detail from the plasma membrane to the cell interior. In addition to significant activation of EGF receptor (EGFR) at tyrosine Tyr845, a remarkable redistribution was detectable for the focal adhesion constituents, integrin ß1 and ß3, and zyxin. Increased activation also applied to focal adhesion kinase (FAK) by phosphorylation at Tyr397, Tyr576, and Src at Tyr418, while total FAK remained unchanged. Risen activity was seen as well for the analyzed distal down-stream events, p190RhoGAP and MAP kinases p42/44. Intriguingly, Src-specific inhibitor Herbimycin A abrogated the entire EGF response except FAK Tyr397 phosphorylation, independent of EGF presence. Mechanistically, our results show that EGF modulates adhesion in a dual fashion, by firstly redistributing focal adhesion constituents to adhesion sites, but also by amplifying levels of activated RhoA antagonist p190RhoGAP, important for cell motility. Further, the findings suggest that the observed EGF response underlies an EGFR integrin cross-talk under recruitment of receptor proximal FAK and Src, and MAP kinase and p190RhoGAP as receptor distal events. Copyright © 2015 Elsevier B.V. All rights reserved.

Extreme European heat waves since 1950 with Heat Wave Magnitude Index and their occurrence in the future

NASA Astrophysics Data System (ADS)

Russo, Simone; Dosio, Alessandro; Sillmann, Jana

2015-04-01

Heat waves are defined as prolonged periods of extremely hot weather and their magnitude and frequency are expected to increase in the future under climate change. Here we grade the heat waves occurred in Europe since 1950, by means of the Heat Wave Magnitude Index (HWMI) applied to daily maximum temperature from European Observation dataset (E-OBS). As shown in many studies the worst event in the last decades occurred in Russia in 2010. However many other heat waves, as shown here and documented in literature and also in newspapers, occurred in different European regions in the past 64 years. In addition, predictions from ten models from the COordinated Regional climate Downscaling EXperiment (CORDEX) under different IPCC AR5 scenarios, suggest an increased probability of occurrence of extreme heat waves by the end of the century. In particular, under the most severe scenario, events of the same severity, as the 2010 Russian heat wave, will become the norm and are projected to occur as often as every two years in the studied region.

A numerical study of diurnally varying surface temperature on flow patterns and pollutant dispersion in street canyons

NASA Astrophysics Data System (ADS)

Tan, Zijing; Dong, Jingliang; Xiao, Yimin; Tu, Jiyuan

2015-03-01

The impacts of the diurnal variation of surface temperature on street canyon flow pattern and pollutant dispersion are investigated based on a two-dimensional street canyon model under different thermal stratifications. Uneven distributed street temperature conditions and a user-defined wall function representing the heat transfer between the air and the street canyon are integrated into the current numerical model. The prediction accuracy of this model is successfully validated against a published wind tunnel experiment. Then, a series of numerical simulations representing four time scenarios (Morning, Afternoon, Noon and Night) are performed at different Bulk Richardson number (Rb). The results demonstrate that uneven distributed street temperature conditions significantly alters street canyon flow structure and pollutant dispersion characteristics compared with conventional uniform street temperature assumption, especially for the morning event. Moreover, air flow patterns and pollutant dispersion are greatly influenced by diurnal variation of surface temperature under unstable stratification conditions. Furthermore, the residual pollutant in near-ground-zone decreases as Rb increases in noon, afternoon and night events under all studied stability conditions.

Event-Related Oscillations in Alcoholism Research: A Review

PubMed Central

Pandey, Ashwini K; Kamarajan, Chella; Rangaswamy, Madhavi; Porjesz, Bernice

2013-01-01

Alcohol dependence is characterized as a multi-factorial disorder caused by a complex interaction between genetic and environmental liabilities across development. A variety of neurocognitive deficits/dysfunctions involving impairments in different brain regions and/or neural circuitries have been associated with chronic alcoholism, as well as with a predisposition to develop alcoholism. Several neurobiological and neurobehavioral approaches and methods of analyses have been used to understand the nature of these neurocognitive impairments/deficits in alcoholism. In the present review, we have examined relatively novel methods of analyses of the brain signals that are collectively referred to as event-related oscillations (EROs) and show promise to further our understanding of human brain dynamics while performing various tasks. These new measures of dynamic brain processes have exquisite temporal resolution and allow the study of neural networks underlying responses to sensory and cognitive events, thus providing a closer link to the physiology underlying them. Here, we have reviewed EROs in the study of alcoholism, their usefulness in understanding dynamical brain functions/dysfunctions associated with alcoholism as well as their utility as effective endophenotypes to identify and understand genes associated with both brain oscillations and alcoholism. PMID:24273686

Gender differences in the impact of stressful life events on changes in body mass index.

PubMed

Udo, Tomoko; Grilo, Carlos M; McKee, Sherry A

2014-12-01

The positive association between stress and weight has been consistently demonstrated, particularly in women. The effect of stress on changes in weight, however, is less clear. A total of 33,425 participants in Wave 1 and Wave 2 surveys of the National Epidemiologic Survey on Alcohol and Related Condition (NESARC) were included in this study. The study examined the relationship between stressful life events during the 12months prior to the Wave 2 interview and changes in body mass index (BMI) between Wave 1 and Wave 2 interviews. Women reported significantly greater increases in BMI than men. Stressful life events, particularly job-related changes, legal problems, and death of family or friends, were associated significantly with increases in BMI among women but not men. In a nationally representative sample, stressful life events were associated with greater weight gain in women. Prevention of weight gain in women should focus on the behavioral and physiological mechanisms underlying female-specific effects of stressful life events on weight gain. Copyright © 2014 Elsevier Inc. All rights reserved.

48 CFR 1553.216-71 - EPA Form 1900-41B, CPAF Contract Individual Performance Event.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Contract Individual Performance Event. 1553.216-71 Section 1553.216-71 Federal Acquisition Regulations... 1900-41B, CPAF Contract Individual Performance Event. As prescribed in 1516.404-278, EPA Form 1900-41B shall be used to document individual performance events under CPAF contracts. ...

78 FR 41125 - Interim Enforcement Policy for Permanent Implant Brachytherapy Medical Event Reporting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... Brachytherapy Medical Event Reporting AGENCY: Nuclear Regulatory Commission. ACTION: Policy statement; revision... medical events occurring under an NRC licensee's permanent implant brachytherapy program. This interim..., ``Adequacy of Medical Event Definitions in 10 CFR [Title 10 of the Code of Federal Regulations] 35.3045, and...

Cell cycle gene expression under clinorotation

NASA Astrophysics Data System (ADS)

Artemenko, Olga

2016-07-01

Cyclins and cyclin-dependent kinase (CDK) are main regulators of the cell cycle of eukaryotes. It's assumes a significant change of their level in cells under microgravity conditions and by other physical factors actions. The clinorotation use enables to determine the influence of gravity on simulated events in the cell during the cell cycle - exit from the state of quiet stage and promotion presynthetic phase (G1) and DNA synthesis phase (S) of the cell cycle. For the clinorotation effect study on cell proliferation activity is the necessary studies of molecular mechanisms of cell cycle regulation and development of plants under altered gravity condition. The activity of cyclin D, which is responsible for the events of the cell cycle in presynthetic phase can be controlled by the action of endogenous as well as exogenous factors, but clinorotation is one of the factors that influence on genes expression that regulate the cell cycle.These data can be used as a model for further research of cyclin - CDK complex for study of molecular mechanisms regulation of growth and proliferation. In this investigation we tried to summarize and analyze known literature and own data we obtained relatively the main regulators of the cell cycle in altered gravity condition.

Pain Now or Later: An Outgrowth Account of Pain-Minimization

PubMed Central

Chen, Shuai; Zhao, Dan; Rao, Li-Lin; Liang, Zhu-Yuan; Li, Shu

2015-01-01

The preference for immediate negative events contradicts the minimizing loss principle given that the value of a delayed negative event is discounted by the amount of time it is delayed. However, this preference is understandable if we assume that the value of a future outcome is not restricted to the discounted utility of the outcome per se but is complemented by an anticipated negative utility assigned to an unoffered dimension, which we termed the “outgrowth.” We conducted three studies to establish the existence of the outgrowth and empirically investigated the mechanism underlying the preference for immediate negative outcomes. Study 1 used a content analysis method to examine whether the outgrowth was generated in accompaniment with the delayed negative events. The results revealed that the investigated outgrowth was composed of two elements. The first component is the anticipated negative emotions elicited by the delayed negative event, and the other is the anticipated rumination during the waiting process, in which one cannot stop thinking about the negative event. Study 2 used a follow-up investigation to examine whether people actually experienced the negative emotions they anticipated in a real situation of waiting for a delayed negative event. The results showed that the participants actually experienced a number of negative emotions when waiting for a negative event. Study 3 examined whether the existence of the outgrowth could make the minimizing loss principle work. The results showed that the difference in pain anticipation between the immediate event and the delayed event could significantly predict the timing preference of the negative event. Our findings suggest that people’s preference for experiencing negative events sooner serves to minimize the overall negative utility, which is divided into two parts: the discounted utility of the outcome itself and an anticipated negative utility assigned to the outgrowth. PMID:25747461

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bozoki, G.E.; Fitzpatrick, R.G.; Bohn, M.P.

This report details the review of the Diablo Canyon Probabilistic Risk Assessment (DCPRA). The study was performed under contract from the Probabilistic Risk Analysis Branch, Office of Nuclear Reactor Research, USNRC by Brookhaven National Laboratory. The DCPRA is a full scope Level I effort and although the review touched on all aspects of the PRA, the internal events and seismic events received the vast majority of the review effort. The report includes a number of independent systems analyses sensitivity studies, importance analyses as well as conclusions on the adequacy of the DCPRA for use in the Diablo Canyon Long Termmore » Seismic Program.« less

Phase II Trials for Heterogeneous Patient Populations with a Time-to-Event Endpoint.

PubMed

Jung, Sin-Ho

2017-07-01

In this paper, we consider a single-arm phase II trial with a time-to-event end-point. We assume that the study population has multiple subpopulations with different prognosis, but the study treatment is expected to be similarly efficacious across the subpopulations. We review a stratified one-sample log-rank test and present its sample size calculation method under some practical design settings. Our sample size method requires specification of the prevalence of subpopulations. We observe that the power of the resulting sample size is not very sensitive to misspecification of the prevalence.

? PID output-feedback control under event-triggered protocol

NASA Astrophysics Data System (ADS)

Zhao, Di; Wang, Zidong; Ding, Derui; Wei, Guoliang; Alsaadi, Fuad E.

2018-07-01

This paper is concerned with the ? proportional-integral-derivative (PID) output-feedback control problem for a class of linear discrete-time systems under event-triggered protocols. The controller and the actuators are connected through a communication network of limited bandwidth, and an event-triggered communication mechanism is adopted to decide when a certain control signal should be transmitted to the respective actuator. Furthermore, a novel PID output-feedback controller is designed where the accumulative sum-loop (the counterpart to the integral-loop in the continues-time setting) operates on a limited time-window with hope to mitigate the effect from the past measurement data. The main objective of the problem under consideration is to design a desired PID controller such that the closed-loop system is exponentially stable and the prescribed ? disturbance rejection attenuation level is guaranteed under event-triggered protocols. By means of the Lyapunov stability theory combined with the orthogonal decomposition, sufficient conditions are established under which the addressed PID controller design problem is recast into a linear convex optimization one that can be easily solved via available software packages. Finally, a simulation example is exploited to illustrate the usefulness and effectiveness of the established control scheme.

Simulating Heinrich events in a coupled atmosphere-ocean-ice sheet model

NASA Astrophysics Data System (ADS)

Mikolajewicz, Uwe; Ziemen, Florian

2016-04-01

Heinrich events are among the most prominent events of long-term climate variability recorded in proxies across the northern hemisphere. They are the archetype of ice sheet - climate interactions on millennial time scales. Nevertheless, the exact mechanisms that cause Heinrich events are still under discussion, and their climatic consequences are far from being fully understood. We contribute to answering the open questions by studying Heinrich events in a coupled ice sheet model (ISM) atmosphere-ocean-vegetation general circulation model (AOVGCM) framework, where this variability occurs as part of the model generated internal variability without the need to prescribe external perturbations, as was the standard approach in almost all model studies so far. The setup consists of a northern hemisphere setup of the modified Parallel Ice Sheet Model (mPISM) coupled to the global coarse resolution AOVGCM ECHAM5/MPIOM/LPJ. The simulations used for this analysis were an ensemble covering substantial parts of the late Glacial forced with transient insolation and prescribed atmospheric greenhouse gas concentrations. The modeled Heinrich events show a marked influence of the ice discharge on the Atlantic circulation and heat transport, but none of the Heinrich events during the Glacial did show a complete collapse of the North Atlantic meridional overturning circulation. The simulated main consequences of the Heinrich events are a freshening and cooling over the North Atlantic and a drying over northern Europe.

Picture Superiority Doubly Dissociates the ERP Correlates of Recollection and Familiarity

ERIC Educational Resources Information Center

Curran, Tim; Doyle, Jeanne

2011-01-01

Two experiments investigated the processes underlying the picture superiority effect on recognition memory. Studied pictures were associated with higher accuracy than studied words, regardless of whether test stimuli were words (Experiment 1) or pictures (Experiment 2). Event-related brain potentials (ERPs) recorded during test suggested that the…

Neural Correlates of Working Memory Performance in Adolescents and Young Adults with Dyslexia

ERIC Educational Resources Information Center

Vasic, Nenad; Lohr, Christina; Steinbrink, Claudia; Martin, Claudia; Wolf, Robert Christian

2008-01-01

Behavioral studies indicate deficits in phonological working memory (WM) and executive functioning in dyslexics. However, little is known about the underlying functional neuroanatomy. In the present study, neural correlates of WM in adolescents and young adults with dyslexia were investigated using event-related functional magnetic resonance…

Weather radar data correlate to hail-induced mortality in grassland birds

USDA-ARS?s Scientific Manuscript database

Large hail can kill animals, but its contribution to annual mortality is under-studied and difficult to quantify. Hail events are challenging to predict, and they often occur in locations where populations are not being studied. Small-bodied terrestrial animals such as songbirds (Order Passeriformes...

Pyranometer offsets triggered by ambient meteorology: insights from laboratory and field experiments

NASA Astrophysics Data System (ADS)

Oswald, Sandro M.; Pietsch, Helga; Baumgartner, Dietmar J.; Weihs, Philipp; Rieder, Harald E.

2017-03-01

This study investigates the effects of ambient meteorology on the accuracy of radiation (R) measurements performed with pyranometers contained in various heating and ventilation systems (HV-systems). It focuses particularly on instrument offsets observed following precipitation events. To quantify pyranometer responses to precipitation, a series of controlled laboratory experiments as well as two targeted field campaigns were performed in 2016. The results indicate that precipitation (as simulated by spray tests or observed under ambient conditions) significantly affects the thermal environment of the instruments and thus their stability. Statistical analyses of laboratory experiments showed that precipitation triggers zero offsets of -4 W m-2 or more, independent of the HV-system. Similar offsets were observed in field experiments under ambient environmental conditions, indicating a clear exceedance of BSRN (Baseline Surface Radiation Network) targets following precipitation events. All pyranometers required substantial time to return to their initial signal states after the simulated precipitation events. Therefore, for BSRN-class measurements, the recommendation would be to flag the radiation measurements during a natural precipitation event and 90 min after it in nighttime conditions. Further daytime experiments show pyranometer offsets of 50 W m-2 or more in comparison to the reference system. As they show a substantially faster recovery, the recommendation would be to flag the radiation measurements within a natural precipitation event and 10 min after it in daytime conditions.

Psychiatric adverse events during treatment with brodalumab: Analysis of psoriasis clinical trials.

PubMed

Lebwohl, Mark G; Papp, Kim A; Marangell, Lauren B; Koo, John; Blauvelt, Andrew; Gooderham, Melinda; Wu, Jashin J; Rastogi, Shipra; Harris, Susan; Pillai, Radhakrishnan; Israel, Robert J

2018-01-01

Individuals with psoriasis are at increased risk for psychiatric comorbidities, including suicidal ideation and behavior (SIB). To distinguish between the underlying risk and potential for treatment-induced psychiatric adverse events in patients with psoriasis being treated with brodalumab, a fully human anti-interleukin 17 receptor A monoclonal antibody. Data were evaluated from a placebo-controlled, phase 2 clinical trial; the open-label, long-term extension of the phase 2 clinical trial; and three phase 3, randomized, double-blind, controlled clinical trials (AMAGINE-1, AMAGINE-2, and AMAGINE-3) and their open-label, long-term extensions of patients with moderate-to-severe psoriasis. The analysis included 4464 patients with 9161.8 patient-years of brodalumab exposure. The follow-up time-adjusted incidence rates of SIB events were comparable between the brodalumab and ustekinumab groups throughout the 52-week controlled phases (0.20 vs 0.60 per 100 patient-years). In the brodalumab group, 4 completed suicides were reported, 1 of which was later adjudicated as indeterminate; all patients had underlying psychiatric disorders or stressors. There was no comparator arm past week 52. Controlled study periods were not powered to detect differences in rare events such as suicide. Comparison with controls and the timing of events do not indicate a causal relationship between SIB and brodalumab treatment. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Transition model for ricin-aptamer interactions with multiple pathways and energy barriers

NASA Astrophysics Data System (ADS)

Wang, Bin; Xu, Bingqian

2014-02-01

We develop a transition model to interpret single-molecule ricin-aptamer interactions with multiple unbinding pathways and energy barriers measured by atomic force microscopy dynamic force spectroscopy. Molecular simulations establish the relationship between binding conformations and the corresponding unbinding pathways. Each unbinding pathway follows a Bell-Evans multiple-barrier model. Markov-type transition matrices are developed to analyze the redistribution of unbinding events among the pathways under different loading rates. Our study provides detailed information about complex behaviors in ricin-aptamer unbinding events.

ASRS Reports on Wake Vortex Encounters

NASA Technical Reports Server (NTRS)

Connell, Linda J.; Taube, Elisa Ann; Drew, Charles Robert; Barclay, Tommy Earl

2010-01-01

ASRS is conducting a structured callback research project of wake vortex incidents reported to the ASRS at all US airports, as well as wake encounters in the enroute environment. This study has three objectives: (1) Utilize the established ASRS supplemental data collection methodology and provide ongoing analysis of wake vortex encounter reports; (2) Document event dynamics and contributing factors underlying wake vortex encounter events; and (3) Support ongoing FAA efforts to address pre-emptive wake vortex risk reduction by utilizing ASRS reporting contributions.

Event Structure and Cognitive Control

PubMed Central

Reimer, Jason F.; Radvansky, Gabriel A.; Lorsbach, Thomas C.; Armendarez, Joseph J.

2017-01-01

Recently, a great deal of research has demonstrated that although everyday experience is continuous in nature, it is parsed into separate events. The aim of the present study was to examine whether event structure can influence the effectiveness of cognitive control. Across five experiments we varied the structure of events within the AX-CPT by shifting the spatial location of cues and probes on a computer screen. When location shifts were present, a pattern of AX-CPT performance consistent with enhanced cognitive control was found. To test whether the location shift effects were caused by the presence of event boundaries per se, other aspects of the AX-CPT were manipulated, such as the color of cues and probes and the inclusion of a distractor task during the cue-probe delay. Changes in cognitive control were not found under these conditions, suggesting that the location shift effects were specifically related to the formation of separate event models. Together, these results can be accounted for by the Event Horizon Model and a representation-based theory of cognitive control, and suggest that cognitive control can be influenced by the surrounding environmental structure. PMID:25603168

Managing the risks of extreme events and disasters to advance climate change adaptation. Special report of the Intergovernmental Panel on Climate Change (IPCC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, C.B.; Barros, V.; Stocker, T.F.

2012-07-01

This Special Report on Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation (SREX) has been jointly coordinated by Working Groups I (WGI) and II (WGII) of the Intergovernmental Panel on Climate Change (IPCC). The report focuses on the relationship between climate change and extreme weather and climate events, the impacts of such events, and the strategies to manage the associated risks. This Special Report, in particular, contributes to frame the challenge of dealing with extreme weather and climate events as an issue in decision making under uncertainty, analyzing response in the context of risk management.more » The report consists of nine chapters, covering risk management; observed and projected changes in extreme weather and climate events; exposure and vulnerability to as well as losses resulting from such events; adaptation options from the local to the international scale; the role of sustainable development in modulating risks; and insights from specific case studies. (LN)« less

Variation of rain intensity and drop size distribution with General Weather Patterns (GWL)

NASA Astrophysics Data System (ADS)

Ghada, Wael; Buras, Allan; Lüpke, Marvin; Menzel, Annette

2017-04-01

Short-duration rainfall extremes may cause flash floods in certain catchments (e.g. cities or fast responding watersheds) and pose a great risk to affected communities. In order to predict their occurrence under future climate change scenarios, their link to atmospheric circulation patterns needs to be well understood. We used a comprehensive data set of meteorological data (temperature, rain gauge precipitation) and precipitation spectra measured by a disdrometer (OTT PARSIVEL) between October 2008 and June 2010 at Freising, southern Germany. For the 21 months of the study period, we integrated the disdrometer spectra over intervals of 10 minutes to correspond to the temporal resolution of the weather station data and discarded measurements with air temperatures below 0°C. Daily General Weather Patterns ("Großwetterlagen", GWL) were downloaded from the website of the German Meteorological Service. Out of the 29 GWL, 14 were included in the analysis for which we had at least 12 rain events during our study period. For the definition of a rain event, we tested different lengths of minimum inter-event times and chose 30 min as a good compromise between number and length of resulting events; rain events started when more than 0.001 mm/h (sensitivity of the disdrometer) were recorded. The length of the rain events ranged between 10 min and 28 h (median 130 min) with the maximum rain intensity recorded being 134 mm/h on 24-07-2009. Seasonal differences were identified for rain event average intensities and maximum intensities per event. The influence of GWL on rain properties such as rain intensity and drop size distribution per time step and per event was investigated based on the above mentioned rain event definition. Pairwise Wilcoxon-tests revealed that higher rain intensity and larger drops were associated with the GWL "Low over the British Isles" (TB), whereas low rain intensities and less drops per interval were associated with the GWL "High over Central Europe" (HM). "Trough over Central Europe" (TRM) was linked to smaller drops and "High Scandinavia-Iceland, Trough C. Europe" (HNFZ) had fewer drops per time step when compared to other GWL types. We also investigated the intra-event behavior regarding fluctuations in rain intensity, rain drop counts, and drop size distribution with time. When combined with predictions of circulation patterns, our analysis provides a detailed insight into the characteristics of rain events under different future climate scenarios, but definitively an extended measurement period and more measurement locations are needed for validation.

Compound Event Barrier Coverage in Wireless Sensor Networks under Multi-Constraint Conditions.

PubMed

Zhuang, Yaoming; Wu, Chengdong; Zhang, Yunzhou; Jia, Zixi

2016-12-24

It is important to monitor compound event by barrier coverage issues in wireless sensor networks (WSNs). Compound event barrier coverage (CEBC) is a novel coverage problem. Unlike traditional ones, the data of compound event barrier coverage comes from different types of sensors. It will be subject to multiple constraints under complex conditions in real-world applications. The main objective of this paper is to design an efficient algorithm for complex conditions that can combine the compound event confidence. Moreover, a multiplier method based on an active-set strategy (ASMP) is proposed to optimize the multiple constraints in compound event barrier coverage. The algorithm can calculate the coverage ratio efficiently and allocate the sensor resources reasonably in compound event barrier coverage. The proposed algorithm can simplify complex problems to reduce the computational load of the network and improve the network efficiency. The simulation results demonstrate that the proposed algorithm is more effective and efficient than existing methods, especially in the allocation of sensor resources.

Compound Event Barrier Coverage in Wireless Sensor Networks under Multi-Constraint Conditions

PubMed Central

Zhuang, Yaoming; Wu, Chengdong; Zhang, Yunzhou; Jia, Zixi

2016-01-01

It is important to monitor compound event by barrier coverage issues in wireless sensor networks (WSNs). Compound event barrier coverage (CEBC) is a novel coverage problem. Unlike traditional ones, the data of compound event barrier coverage comes from different types of sensors. It will be subject to multiple constraints under complex conditions in real-world applications. The main objective of this paper is to design an efficient algorithm for complex conditions that can combine the compound event confidence. Moreover, a multiplier method based on an active-set strategy (ASMP) is proposed to optimize the multiple constraints in compound event barrier coverage. The algorithm can calculate the coverage ratio efficiently and allocate the sensor resources reasonably in compound event barrier coverage. The proposed algorithm can simplify complex problems to reduce the computational load of the network and improve the network efficiency. The simulation results demonstrate that the proposed algorithm is more effective and efficient than existing methods, especially in the allocation of sensor resources. PMID:28029118

The deep Peru 2015 doublet earthquakes

NASA Astrophysics Data System (ADS)

Ruiz, S.; Tavera, H.; Poli, P.; Herrera, C.; Flores, C.; Rivera, E.; Madariaga, R.

2017-11-01

On 24 November 2015 two events of magnitude Mw 7.5 and Mw 7.6 occurred at 600 km depth under the Peru-Brazil boundary. These two events were separated in time by 300 s. Deep event doublets occur often under South America. The characteristics that control these events and the dynamic interaction between them are an unresolved problem. We used teleseismic and regional data, situated above the doublet, to perform source inversion in order to characterize their ruptures. The overall resemblance between these two events suggests that they share similar rupture process. They are not identical but occur on the same fault surface dipping westward. Using a P-wave stripping and stretching method we determine rupture speed of 2.25 km/s. From regional body wave inversion we find that stress drop is similar for both events, they differ by a factor of two. The similarity in geometry, rupture velocity, stress drop and radiated energy, suggests that these two events looked like simple elliptical ruptures that propagated like classical sub-shear brittle cracks.

Development and validation of Aviation Causal Contributors for Error Reporting Systems (ACCERS).

PubMed

Baker, David P; Krokos, Kelley J

2007-04-01

This investigation sought to develop a reliable and valid classification system for identifying and classifying the underlying causes of pilot errors reported under the Aviation Safety Action Program (ASAP). ASAP is a voluntary safety program that air carriers may establish to study pilot and crew performance on the line. In ASAP programs, similar to the Aviation Safety Reporting System, pilots self-report incidents by filing a short text description of the event. The identification of contributors to errors is critical if organizations are to improve human performance, yet it is difficult for analysts to extract this information from text narratives. A taxonomy was needed that could be used by pilots to classify the causes of errors. After completing a thorough literature review, pilot interviews and a card-sorting task were conducted in Studies 1 and 2 to develop the initial structure of the Aviation Causal Contributors for Event Reporting Systems (ACCERS) taxonomy. The reliability and utility of ACCERS was then tested in studies 3a and 3b by having pilots independently classify the primary and secondary causes of ASAP reports. The results provided initial evidence for the internal and external validity of ACCERS. Pilots were found to demonstrate adequate levels of agreement with respect to their category classifications. ACCERS appears to be a useful system for studying human error captured under pilot ASAP reports. Future work should focus on how ACCERS is organized and whether it can be used or modified to classify human error in ASAP programs for other aviation-related job categories such as dispatchers. Potential applications of this research include systems in which individuals self-report errors and that attempt to extract and classify the causes of those events.

Comparison of prediction models for use of medical resources at urban auto-racing events.

PubMed

Nable, Jose V; Margolis, Asa M; Lawner, Benjamin J; Hirshon, Jon Mark; Perricone, Alexander J; Galvagno, Samuel M; Lee, Debra; Millin, Michael G; Bissell, Richard A; Alcorta, Richard L

2014-12-01

INTRODUCTION Predicting the number of patient encounters and transports during mass gatherings can be challenging. The nature of these events necessitates that proper resources are available to meet the needs that arise. Several prediction models to assist event planners in forecasting medical utilization have been proposed in the literature. The objective of this study was to determine the accuracy of the Arbon and Hartman models in predicting the number of patient encounters and transportations from the Baltimore Grand Prix (BGP), held in 2011 and 2012. It was hypothesized that the Arbon method, which utilizes regression model-derived equations to estimate, would be more accurate than the Hartman model, which categorizes events into only three discreet severity types. This retrospective analysis of the BGP utilized data collected from an electronic patient tracker system. The actual number of patients evaluated and transported at the BGP was tabulated and compared to the numbers predicted by the two studied models. Several environmental features including weather, crowd attendance, and presence of alcohol were used in the Arbon and Hartman models. Approximately 130,000 spectators attended the first event, and approximately 131,000 attended the second. The number of patient encounters per day ranged from 19 to 57 in 2011, and the number of transports from the scene ranged from two to nine. In 2012, the number of patients ranged from 19 to 44 per day, and the number of transports to emergency departments ranged from four to nine. With the exception of one day in 2011, the Arbon model over predicted the number of encounters. For both events, the Hartman model over predicted the number of patient encounters. In regard to hospital transports, the Arbon model under predicted the actual numbers whereas the Hartman model both over predicted and under predicted the number of transports from both events, varying by day. These findings call attention to the need for the development of a versatile and accurate model that can more accurately predict the number of patient encounters and transports associated with mass-gathering events so that medical needs can be anticipated and sufficient resources can be provided.

Beyond Framingham risk factors and coronary calcification: does aortic valve calcification improve risk prediction? The Heinz Nixdorf Recall Study.

PubMed

Kälsch, Hagen; Lehmann, Nils; Mahabadi, Amir A; Bauer, Marcus; Kara, Kaffer; Hüppe, Patricia; Moebus, Susanne; Möhlenkamp, Stefan; Dragano, Nico; Schmermund, Axel; Stang, Andreas; Jöckel, Karl-Heinz; Erbel, Raimund

2014-06-01

Aortic valve calcification (AVC) is considered a manifestation of atherosclerosis. In this study, we investigated whether AVC adds to cardiovascular risk prediction beyond Framingham risk factors and coronary artery calcification (CAC). A total of 3944 subjects from the population based Heinz Nixdorf Recall Study (59.3±7.7 years; 53% females) were evaluated for coronary events, stroke, and cardiovascular disease (CVD) events (including all plus CV death) over 9.1±1.9 years. CT scans were performed to quantify AVC. Cox proportional hazards regressions and Harrell's C were used to examine AVC as event predictor in addition to risk factors and CAC. During follow-up, 138 (3.5%) subjects experienced coronary events, 101 (2.6%) had a stroke, and 257 (6.5%) experienced CVD events. In subjects with AVC>0 versus AVC=0 the incidence of coronary events was 8.0% versus 3.0% (p<0.001) and the incidence of CVD events was 13.0% versus 5.7% (p<0.001). The frequency of events increased significantly with increasing AVC scores (p<0.001). After adjustment for Framingham risk factors, high AVC scores (3rd tertile) remained independently associated with coronary events (HR 2.21, 95% CI 1.28 to 3.81) and CVD events (HR 1.67, 95% CI 1.08 to 2.58). After further adjustment for CAC score, HRs were attenuated (coronary events 1.55, 95% CI 0.89 to 2.69; CVD events 1.29, 95% CI 0.83 to 2.00). When adding AVC to the model containing traditional risk factors and CAC, Harrell's C indices did not increase for coronary events (from 0.744 to 0.744) or CVD events (from 0.759 to 0.759). AVC is associated with incident coronary and CVD events independent of Framingham risk factors. However, AVC fails to improve cardiovascular event prediction over Framingham risk factors and CAC. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, Hongxiang; Sun, Ning; Wigmosta, Mark

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial over-/under-estimation of design basis events and subsequent over-/under-design of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme eventsmore » at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to under-design, many with significant under-estimation of 100-year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for under-design were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for over-design at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.« less

A class of temporal boundaries derived by quantifying the sense of separation.

PubMed

Paine, Llewyn Elise; Gilden, David L

2013-12-01

The perception of moment-to-moment environmental flux as being composed of meaningful events requires that memory processes coordinate with cues that signify beginnings and endings. We have constructed a technique that allows this coordination to be monitored indirectly. This technique works by embedding a sequential priming task into the event under study. Memory and perception must be coordinated to resolve temporal flux into scenes. The implicit memory processes inherent in sequential priming are able to effectively shadow then mirror scene-forming processes. Certain temporal boundaries are found to weaken the strength of irrelevant feature priming, a signal which can then be used in more ambiguous cases to infer how people segment time. Over the course of 13 independent studies, we were able to calibrate the technique and then use it to measure the strength of event segmentation in several instructive contexts that involved both visual and auditory modalities. The signal generated by sequential priming may permit the sense of separation between events to be measured as an extensive psychophysical quantity.

Joint model-based clustering of nonlinear longitudinal trajectories and associated time-to-event data analysis, linked by latent class membership: with application to AIDS clinical studies.

PubMed

Huang, Yangxin; Lu, Xiaosun; Chen, Jiaqing; Liang, Juan; Zangmeister, Miriam

2017-10-27

Longitudinal and time-to-event data are often observed together. Finite mixture models are currently used to analyze nonlinear heterogeneous longitudinal data, which, by releasing the homogeneity restriction of nonlinear mixed-effects (NLME) models, can cluster individuals into one of the pre-specified classes with class membership probabilities. This clustering may have clinical significance, and be associated with clinically important time-to-event data. This article develops a joint modeling approach to a finite mixture of NLME models for longitudinal data and proportional hazard Cox model for time-to-event data, linked by individual latent class indicators, under a Bayesian framework. The proposed joint models and method are applied to a real AIDS clinical trial data set, followed by simulation studies to assess the performance of the proposed joint model and a naive two-step model, in which finite mixture model and Cox model are fitted separately.

40 CFR 72.11 - Computation of time.

Code of Federal Regulations, 2014 CFR

2014-07-01

... event shall begin on the day the act or event occurs. (b) Unless otherwise stated, any time period scheduled, under the Acid Rain Program, to begin before the occurrence of an act or event shall be computed so that the period ends on the day before the act or event occurs. (c) Unless otherwise stated, if...

40 CFR 72.11 - Computation of time.

Code of Federal Regulations, 2010 CFR

2010-07-01

... event shall begin on the day the act or event occurs. (b) Unless otherwise stated, any time period scheduled, under the Acid Rain Program, to begin before the occurrence of an act or event shall be computed so that the period ends on the day before the act or event occurs. (c) Unless otherwise stated, if...

40 CFR 72.11 - Computation of time.

Code of Federal Regulations, 2011 CFR

2011-07-01

... event shall begin on the day the act or event occurs. (b) Unless otherwise stated, any time period scheduled, under the Acid Rain Program, to begin before the occurrence of an act or event shall be computed so that the period ends on the day before the act or event occurs. (c) Unless otherwise stated, if...

40 CFR 72.11 - Computation of time.

Code of Federal Regulations, 2013 CFR

2013-07-01

... event shall begin on the day the act or event occurs. (b) Unless otherwise stated, any time period scheduled, under the Acid Rain Program, to begin before the occurrence of an act or event shall be computed so that the period ends on the day before the act or event occurs. (c) Unless otherwise stated, if...

Enhancing Young Infants' Representations of Physical Events through Improved Retrieval (Not Encoding) of Information

ERIC Educational Resources Information Center

Wang, Su-hua; Onishi, Kristine H.

2017-01-01

Infants' representations of physical events are surprisingly flexible. Brief exposure to one event can immediately enhance infants' representations of another event. The present experiments tested two potential mechanisms underlying this priming: enhanced encoding or improved retrieval. Five-month-olds saw a target block become hidden inside a…

40 CFR 72.11 - Computation of time.

Code of Federal Regulations, 2012 CFR

2012-07-01

... event shall begin on the day the act or event occurs. (b) Unless otherwise stated, any time period scheduled, under the Acid Rain Program, to begin before the occurrence of an act or event shall be computed so that the period ends on the day before the act or event occurs. (c) Unless otherwise stated, if...

40 CFR 86.1370-2007 - Not-To-Exceed test procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., BFSC must be calculated under the general test cell conditions specified in § 86.1330. The manufacturer... regeneration events, if a regeneration event occurs during the NTE test, then the averaging period must be at least as long as the time between the events multiplied by the number of full regeneration events within...

78 FR 29519 - Physical Protection of Irradiated Reactor Fuel in Transit

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... to the appropriate response forces of any sabotage events, and (3) impede attempts at radiological... personnel so that they could properly respond to a safety or safeguards event. The State of Nevada concluded... destination, and must immediately notify the appropriate agencies in the event of a safeguards event under the...

Effects of natural and simulated rainfall on indicators of ensilability and nutritive value for wilting alfalfa forages sampled before preservation as silage.

PubMed

Coblentz, W K; Muck, R E

2012-11-01

The frustrations of forage producers attempting to conserve high-quality alfalfa (Medicago sativa L.) silage during periods of unstable or inclement weather are widely known. Our objectives for this series of studies were to (1) assess indicators of ensilability, such as pH, buffering capacity, water-soluble carbohydrates (WSC), and starch for wilting alfalfa forages receiving no rainfall or damaged by simulated or natural rainfall events; (2) use these data as inputs to calculate the threshold moisture concentration that would prohibit a clostridially dominated fermentation; and (3) further evaluate the effects of rain damage or no rain damage on measures of forage nutritive value. Rainfall events were applied to wilting forages by both simulated and natural methods over multiple studies distributed across 4 independent forage harvests. Generally, simulated rainfall was applied to alfalfa under controlled conditions in which forages were relatively wet at the time of application, and subsequently were dried to final moisture endpoints under near ideal conditions within a constant temperature/humidity environmental chamber, thereby limiting postwetting wilting time to ≤21 h. As a result, indicators of ensilability, as well as measures of nutritive value, changed only marginally as a result of treatment. Consistently, reductions in concentrations of WSC and starch occurred, but changes in WSC were relatively modest, and postwetting concentrations of WSC may have been buoyed by hydrolysis of starch. When forages were subjected to natural rainfall events followed by prolonged exposure under field conditions, indicators of ensilability were much less desirable. In one study in which alfalfa received 49.3mm of natural rainfall over a prolonged (8-d) field-exposure period, fresh pH increased from 6.48 to 7.43 within all forages exposed to these extended, moist wilting conditions. Furthermore, sharp reductions were observed in buffering capacity (410 vs. 337 meq/kg of DM), WSC (6.13 vs. 2.90%), starch (2.28 vs. 0.45%), and clostridially dominated fermentation (62.7 vs. 59.4%). Based on these experiments, the potential for good fermentation is affected only minimally by single rainfall events applied to relatively wet forages, provided these events are followed by rapid dehydration; however, attaining acceptable silage fermentations with forages subjected to prolonged exposure under poor drying conditions is likely to be far more problematic. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Effects of expectation congruency on event-related potentials (ERPs) to facial expressions depend on cognitive load during the expectation phase.

PubMed

Lin, Huiyan; Schulz, Claudia; Straube, Thomas

2016-10-01

Previous studies have shown that event-related potentials (ERPs) to facial expressions are modulated by expectation (congruency) and that the ERP effects of expectation congruency are altered by cognitive tasks during the expectation phase. However, it is as yet unknown whether the congruency ERP effects can be modulated by the amount of cognitive load during the expectation phase. To address this question, electroencephalogram (EEG) was acquired when participants viewed fearful and neutral facial expressions. Before the presentation of facial expressions, a cue indicating the expression of a face and subsequently, an expectation interval without any cues were presented. Facial expressions were congruent with the cues in 75% of all trials. During the expectation interval, participants had to solve a cognitive task, in which several letters were presented for target letter detection. The letters were all the same under low load, but differed under high load. Event-related potential (ERP) results showed that the amount of cognitive load during the expectation phase altered the congruency effect in N2 and EPN amplitudes for fearful faces. Congruent as compared to incongruent fearful expressions elicited larger N2 and smaller EPN amplitudes under low load, but these congruency effects were not observed under high load. For neutral faces, a congruency effect in late positive potential (LPP) amplitudes was modulated by cognitive load during the expectation phase. The LPP was more positive for incongruent as compared to congruent faces under low load, but the congruency effect was not evident under high load. The findings indicate that congruency effects on ERPs are modulated by the amount of cognitive load the expectation phase and that this modulation is altered by facial expression. Copyright © 2016 Elsevier B.V. All rights reserved.

Best Communication Practices for Preparation of Exceptional Event Demonstrations

EPA Pesticide Factsheets

OAQPS developed this document of Best Practices based on input received from EPA regional offices and selected state/local air agencies who submitted Exceptional Event Demonstrations under the 2007 version of the Exceptional Events Rule (EE Rule).

Ticagrelor vs prasugrel one-month maintenance therapy: impact on platelet reactivity and bleeding events.

PubMed

Alexopoulos, D; Stavrou, K; Koniari, I; Gkizas, V; Perperis, A; Kontoprias, K; Vogiatzi, C; Bampouri, T; Xanthopoulou, I

2014-09-02

Platelet reactivity (PR) and bleeding events following therapy with ticagrelor vs prasugrel have not been adequately studied. We aimed to compare PR and bleeding events in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) while on ticagrelor vs prasugrel for one month. Consecutive patients who were discharged either on ticagrelor 90 mg bid maintenance dose (MD) or prasugrel 10 mg MD were invited for PR assessment (VerifyNow, in PRU) at one month. High PR (HPR) was defined as >208 PRU. Bleeding events [Bleeding Academic Research Consortium (BARC) classification] were monitored. Out of 937 screened patients, 512 were analysed, 278 under ticagrelor MD and 234 under prasugrel MD. PR at 30 days (C-statistic of the propensity score model 0.63, 0.58-0.67 95% CI, p<0.001) was lower when on ticagrelor compared with prasugrel (33.3, 95% CI 29.3-37.3 vs 84.6, 95% CI 73.6-95.6, p<0.001). In the analysed population more BARC type 1 bleeding events were observed with ticagrelor compared to prasugrel (36.7% vs 28.2%, p=0.047). In 221 propensity score matched pairs, BARC type 1 bleeding rate was marginally higher in ticagrelor vs prasugrel treated patients (35.7% vs 27.1%, p=0.05). BARC type ≥2 events did not differ between groups 5 (2.3%) vs 5 (2.3%). HPR rate was higher for prasugrel-treated patients (5.4% vs 0%, p<0.001). In conclusion, in patients with ACS undergoing PCI, ticagrelor MD produces a significantly higher platelet inhibition compared to prasugrel MD. This pharmacodynamic difference might be associated with more nuisance bleeding events with ticagrelor use.

A systematic comparison of recurrent event models for application to composite endpoints.

PubMed

Ozga, Ann-Kathrin; Kieser, Meinhard; Rauch, Geraldine

2018-01-04

Many clinical trials focus on the comparison of the treatment effect between two or more groups concerning a rarely occurring event. In this situation, showing a relevant effect with an acceptable power requires the observation of a large number of patients over a long period of time. For feasibility issues, it is therefore often considered to include several event types of interest, non-fatal or fatal, and to combine them within a composite endpoint. Commonly, a composite endpoint is analyzed with standard survival analysis techniques by assessing the time to the first occurring event. This approach neglects that an individual may experience more than one event which leads to a loss of information. As an alternative, composite endpoints could be analyzed by models for recurrent events. There exists a number of such models, e.g. regression models based on count data or Cox-based models such as the approaches of Andersen and Gill, Prentice, Williams and Peterson or, Wei, Lin and Weissfeld. Although some of the methods were already compared within the literature there exists no systematic investigation for the special requirements regarding composite endpoints. Within this work a simulation-based comparison of recurrent event models applied to composite endpoints is provided for different realistic clinical trial scenarios. We demonstrate that the Andersen-Gill model and the Prentice- Williams-Petersen models show similar results under various data scenarios whereas the Wei-Lin-Weissfeld model delivers effect estimators which can considerably deviate under commonly met data scenarios. Based on the conducted simulation study, this paper helps to understand the pros and cons of the investigated methods in the context of composite endpoints and provides therefore recommendations for an adequate statistical analysis strategy and a meaningful interpretation of results.

Children's Representation and Imitation of Events: How Goal Organization Influences 3-Year-Old Children's Memory for Action Sequences.

PubMed

Loucks, Jeff; Mutschler, Christina; Meltzoff, Andrew N

2017-09-01

Children's imitation of adults plays a prominent role in human cognitive development. However, few studies have investigated how children represent the complex structure of observed actions which underlies their imitation. We integrate theories of action segmentation, memory, and imitation to investigate whether children's event representation is organized according to veridical serial order or a higher level goal structure. Children were randomly assigned to learn novel event sequences either through interactive hands-on experience (Study 1) or via storybook (Study 2). Results demonstrate that children's representation of observed actions is organized according to higher level goals, even at the cost of representing the veridical temporal ordering of the sequence. We argue that prioritizing goal structure enhances event memory, and that this mental organization is a key mechanism of social-cognitive development in real-world, dynamic environments. It supports cultural learning and imitation in ecologically valid settings when social agents are multitasking and not demonstrating one isolated goal at a time. Copyright © 2016 Cognitive Science Society, Inc.

Stress-inducible expression of At DREB1A in transgenic peanut (Arachis hypogaea L.) increases transpiration efficiency under water-limiting conditions.

PubMed

Bhatnagar-Mathur, Pooja; Devi, M Jyostna; Reddy, D Srinivas; Lavanya, M; Vadez, Vincent; Serraj, R; Yamaguchi-Shinozaki, K; Sharma, Kiran K

2007-12-01

Water deficit is the major abiotic constraint affecting crop productivity in peanut (Arachis hypogaea L.). Water use efficiency under drought conditions is thought to be one of the most promising traits to improve and stabilize crop yields under intermittent water deficit. A transcription factor DREB1A from Arabidopsis thaliana, driven by the stress inducible promoter from the rd29A gene, was introduced in a drought-sensitive peanut cultivar JL 24 through Agrobacterium tumefaciens-mediated gene transfer. The stress inducible expression of DREB1A in these transgenic plants did not result in growth retardation or visible phenotypic alterations. T3 progeny of fourteen transgenic events were exposed to progressive soil drying in pot culture. The soil moisture threshold where their transpiration rate begins to decline relative to control well-watered (WW) plants and the number of days needed to deplete the soil water was used to rank the genotypes using the average linkage cluster analysis. Five diverse events were selected from the different clusters and further tested. All the selected transgenic events were able to maintain a transpiration rate equivalent to the WW control in soils dry enough to reduce transpiration rate in wild type JL 24. All transgenic events except one achieved higher transpiration efficiency (TE) under WW conditions and this appeared to be explained by a lower stomatal conductance. Under water limiting conditions, one of the selected transgenic events showed 40% higher TE than the untransformed control.

The experience of traumatic events disrupts the measurement invariance of a posttraumatic stress scale.

PubMed

Lommen, Miriam J J; van de Schoot, Rens; Engelhard, Iris M

2014-01-01

Studies that include multiple assessments of a particular instrument within the same population are based on the presumption that this instrument measures the same construct over time. But what if the meaning of the construct changes over time due to one's experiences? For example, the experience of a traumatic event can influence one's view of the world, others, and self, and may disrupt the stability of a questionnaire measuring posttraumatic stress symptoms (i.e., it may affect the interpretation of items). Nevertheless, assessments before and after such a traumatic event are crucial to study longitudinal development of posttraumatic stress symptoms. In this study, we examined measurement invariance of posttraumatic stress symptoms in a sample of Dutch soldiers before and after they went on deployment to Afghanistan (N = 249). Results showed that the underlying measurement model before deployment was different from the measurement model after deployment due to invariant item thresholds. These results were replicated in a sample of soldiers deployed to Iraq (N = 305). Since the lack of measurement invariance was due to instability of the majority of the items, it seems reasonable to conclude that the underlying construct of PSS is unstable over time if war-zone related traumatic events occur in between measurements. From a statistical point of view, the scores over time cannot be compared when there is a lack of measurement invariance. The main message of this paper is that researchers working with posttraumatic stress questionnaires in longitudinal studies should not take measurement invariance for granted, but should use pre- and post-symptom scores as different constructs for each time point in the analysis.

Lessons from non-canonical splicing

PubMed Central

Ule, Jernej

2016-01-01

Recent improvements in experimental and computational techniques used to study the transcriptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-canonical splicing events. This includes cryptic events located far from the currently annotated exons, and unconventional splicing mechanisms that have important roles in regulating gene expression. These non-canonical splicing events are a major source of newly emerging transcripts during evolution, especially when they involve sequences derived from transposable elements. They are therefore under precise regulation and quality control, which minimises their potential to disrupt gene expression. While non-canonical splicing can lead to aberrant transcripts that cause many diseases, we also explain how it can be exploited for new therapeutic strategies. PMID:27240813

Swimming against the tide: resilience of a riverine turtle to recurrent extreme environmental events.

PubMed

Jergenson, Abigail M; Miller, David A W; Neuman-Lee, Lorin A; Warner, Daniel A; Janzen, Fredric J

2014-03-01

Extreme environmental events (EEEs) are likely to exert deleterious effects on populations. From 1996 to 2012 we studied the nesting dynamics of a riverine population of painted turtles (Chrysemys picta) that experienced seven years with significantly definable spring floods. We used capture-mark-recapture methods to estimate the relationships between more than 5 m and more than 6 m flood events and population parameters. Contrary to expectations, flooding was not associated with annual differences in survival, recruitment or annual population growth rates of the adult female segment of the population. These findings suggest that female C. picta exhibit resiliency to key EEE, which are expected to increase in frequency under climate change.

Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence

NASA Technical Reports Server (NTRS)

Tlsty, T. D.; Romanov, S. R.; Kozakiewicz, B. K.; Holst, C. R.; Haupt, L. M.; Crawford, Y. G.

2001-01-01

The genomic changes that foster cancer can be either genetic or epigenetic in nature. Early studies focused on genetic changes and how mutational events contribute to changes in gene expression. These point mutations, deletions and amplifications are known to activate oncogenes and inactivate tumor suppressor genes. More recently, multiple epigenetic changes that can have a profound effect on carcinogenesis have been identified. These epigenetic events, such as the methylation of promoter sequences in genes, are under active investigation. In this review we will describe a methylation event that occurs during the propagation of human mammary epithelial cells (HMEC) in culture and detail the accompanying genetic alterations that have been observed.

Development of a Bayesian Belief Network Runway Incursion and Excursion Model

NASA Technical Reports Server (NTRS)

Green, Lawrence L.

2014-01-01

In a previous work, a statistical analysis of runway incursion (RI) event data was conducted to ascertain the relevance of this data to the top ten Technical Challenges (TC) of the National Aeronautics and Space Administration (NASA) Aviation Safety Program (AvSP). The study revealed connections to several of the AvSP top ten TC and identified numerous primary causes and contributing factors of RI events. The statistical analysis served as the basis for developing a system-level Bayesian Belief Network (BBN) model for RI events, also previously reported. Through literature searches and data analysis, this RI event network has now been extended to also model runway excursion (RE) events. These RI and RE event networks have been further modified and vetted by a Subject Matter Expert (SME) panel. The combined system-level BBN model will allow NASA to generically model the causes of RI and RE events and to assess the effectiveness of technology products being developed under NASA funding. These products are intended to reduce the frequency of runway safety incidents/accidents, and to improve runway safety in general. The development and structure of the BBN for both RI and RE events are documented in this paper.

Re-Evaluating Dissociations between Implicit and Explicit Category Learning: An Event-Related fMRI Study

ERIC Educational Resources Information Center

Gureckis, Todd M.; James, Thomas W.; Nosofsky, Robert M.

2011-01-01

Recent fMRI studies have found that distinct neural systems may mediate perceptual category learning under implicit and explicit learning conditions. In these previous studies, however, different stimulus-encoding processes may have been associated with implicit versus explicit learning. The present design was aimed at decoupling the influence of…

Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study.

PubMed

Generaal, Ellen; Vogelzangs, Nicole; Macfarlane, Gary J; Geenen, Rinie; Smit, Johannes H; de Geus, Eco J C N; Penninx, Brenda W J H; Dekker, Joost

2016-05-01

Dysregulated biological stress systems and adverse life events, independently and in interaction, have been hypothesised to initiate chronic pain. We examine whether (1) function of biological stress systems, (2) adverse life events, and (3) their combination predict the onset of chronic multisite musculoskeletal pain. Subjects (n=2039) of the Netherlands Study of Depression and Anxiety, free from chronic multisite musculoskeletal pain at baseline, were identified using the Chronic Pain Grade Questionnaire and followed up for the onset of chronic multisite musculoskeletal pain over 6 years. Baseline assessment of biological stress systems comprised function of the hypothalamic-pituitary-adrenal axis (1-h cortisol awakening response, evening levels, postdexamethasone levels), the immune system (basal and lipopolysaccharide-stimulated inflammation) and the autonomic nervous system (heart rate, pre-ejection period, SD of the normal-to-normal interval, respiratory sinus arrhythmia). The number of recent adverse life events was assessed at baseline using the List of Threatening Events Questionnaire. Hypothalamic-pituitary-adrenal axis, immune system and autonomic nervous system functioning was not associated with onset of chronic multisite musculoskeletal pain, either by itself or in interaction with adverse life events. Adverse life events did predict onset of chronic multisite musculoskeletal pain (HR per event=1.14, 95% CI 1.04 to 1.24, p=0.005). This longitudinal study could not confirm that dysregulated biological stress systems increase the risk of developing chronic multisite musculoskeletal pain. Adverse life events were a risk factor for the onset of chronic multisite musculoskeletal pain, suggesting that psychosocial factors play a role in triggering the development of this condition. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Life events and borderline personality features: the influence of gene-environment interaction and gene-environment correlation.

PubMed

Distel, M A; Middeldorp, C M; Trull, T J; Derom, C A; Willemsen, G; Boomsma, D I

2011-04-01

Traumatic life events are generally more common in patients with borderline personality disorder (BPD) than in non-patients or patients with other personality disorders. This study investigates whether exposure to life events moderates the genetic architecture of BPD features. As the presence of genotype-environment correlation (rGE) can lead to spurious findings of genotype-environment interaction (G × E), we also test whether BPD features increase the likelihood of exposure to life events. The extent to which an individual is at risk to develop BPD was assessed with the Personality Assessment Inventory - Borderline features scale (PAI-BOR). Life events under study were a divorce/break-up, traffic accident, violent assault, sexual assault, robbery and job loss. Data were available for 5083 twins and 1285 non-twin siblings. Gene-environment interaction and correlation were assessed by using structural equation modelling (SEM) and the co-twin control design. There was evidence for both gene-environment interaction and correlation. Additive genetic influences on BPD features interacted with the exposure to sexual assault, with genetic variance being lower in exposed individuals. In individuals who had experienced a divorce/break-up, violent assault, sexual assault or job loss, environmental variance for BPD features was higher, leading to a lower heritability of BPD features in exposed individuals. Gene-environment correlation was present for some life events. The genes that influence BPD features thus also increased the likelihood of being exposed to certain life events. To our knowledge, this study is the first to test the joint effect of genetic and environmental influences and the exposure to life events on BPD features in the general population. Our results indicate the importance of both genetic vulnerability and life events.

False memory and level of processing effect: an event-related potential study.

PubMed

Beato, Maria Soledad; Boldini, Angela; Cadavid, Sara

2012-09-12

Event-related potentials (ERPs) were used to determine the effects of level of processing on true and false memory, using the Deese-Roediger-McDermott (DRM) paradigm. In the DRM paradigm, lists of words highly associated to a single nonpresented word (the 'critical lure') are studied and, in a subsequent memory test, critical lures are often falsely remembered. Lists with three critical lures per list were auditorily presented here to participants who studied them with either a shallow (saying whether the word contained the letter 'o') or a deep (creating a mental image of the word) processing task. Visual presentation modality was used on a final recognition test. True recognition of studied words was significantly higher after deep encoding, whereas false recognition of nonpresented critical lures was similar in both experimental groups. At the ERP level, true and false recognition showed similar patterns: no FN400 effect was found, whereas comparable left parietal and late right frontal old/new effects were found for true and false recognition in both experimental conditions. Items studied under shallow encoding conditions elicited more positive ERP than items studied under deep encoding conditions at a 1000-1500 ms interval. These ERP results suggest that true and false recognition share some common underlying processes. Differential effects of level of processing on true and false memory were found only at the behavioral level but not at the ERP level.

Seismic Characterization of the Newberry and Cooper Basin EGS Sites

NASA Astrophysics Data System (ADS)

Templeton, D. C.; Wang, J.; Goebel, M.; Johannesson, G.; Myers, S. C.; Harris, D.; Cladouhos, T. T.

2015-12-01

To aid in the seismic characterization of Engineered Geothermal Systems (EGS), we enhance traditional microearthquake detection and location methodologies at two EGS systems: the Newberry EGS site and the Habanero EGS site in the Cooper Basin of South Australia. We apply the Matched Field Processing (MFP) seismic imaging technique to detect new seismic events using known discrete microearthquake sources. Events identified using MFP typically have smaller magnitudes or occur within the coda of a larger event. Additionally, we apply a Bayesian multiple-event location algorithm, called MicroBayesLoc, to estimate the 95% probability ellipsoids for events with high signal-to-noise ratios (SNR). Such probability ellipsoid information can provide evidence for determining if a seismic lineation is real, or simply within the anticipated error range. At the Newberry EGS site, 235 events were reported in the original catalog. MFP identified 164 additional events (an increase of over 70% more events). For the relocated events in the Newberry catalog, we can distinguish two distinct seismic swarms that fall outside of one another's 95% probability error ellipsoids.This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

Analysis of Phase-Type Stochastic Petri Nets With Discrete and Continuous Timing

NASA Technical Reports Server (NTRS)

Jones, Robert L.; Goode, Plesent W. (Technical Monitor)

2000-01-01

The Petri net formalism is useful in studying many discrete-state, discrete-event systems exhibiting concurrency, synchronization, and other complex behavior. As a bipartite graph, the net can conveniently capture salient aspects of the system. As a mathematical tool, the net can specify an analyzable state space. Indeed, one can reason about certain qualitative properties (from state occupancies) and how they arise (the sequence of events leading there). By introducing deterministic or random delays, the model is forced to sojourn in states some amount of time, giving rise to an underlying stochastic process, one that can be specified in a compact way and capable of providing quantitative, probabilistic measures. We formalize a new non-Markovian extension to the Petri net that captures both discrete and continuous timing in the same model. The approach affords efficient, stationary analysis in most cases and efficient transient analysis under certain restrictions. Moreover, this new formalism has the added benefit in modeling fidelity stemming from the simultaneous capture of discrete- and continuous-time events (as opposed to capturing only one and approximating the other). We show how the underlying stochastic process, which is non-Markovian, can be resolved into simpler Markovian problems that enjoy efficient solutions. Solution algorithms are provided that can be easily programmed.

The detection and analysis of point processes in biological signals

NASA Technical Reports Server (NTRS)

Anderson, D. J.; Correia, M. J.

1977-01-01

A pragmatic approach to the detection and analysis of discrete events in biomedical signals is taken. Examples from both clinical and basic research are provided. Introductory sections discuss not only discrete events which are easily extracted from recordings by conventional threshold detectors but also events embedded in other information carrying signals. The primary considerations are factors governing event-time resolution and the effects limits to this resolution have on the subsequent analysis of the underlying process. The analysis portion describes tests for qualifying the records as stationary point processes and procedures for providing meaningful information about the biological signals under investigation. All of these procedures are designed to be implemented on laboratory computers of modest computational capacity.

A Metaphor-Enriched Social Cognition

ERIC Educational Resources Information Center

Landau, Mark J.; Meier, Brian P.; Keefer, Lucas A.

2010-01-01

Social cognition is the scientific study of the cognitive events underlying social thought and attitudes. Currently, the field's prevailing theoretical perspectives are the traditional schema view and embodied cognition theories. Despite important differences, these perspectives share the seemingly uncontroversial notion that people interpret and…

Optimal bridge retrofit strategy to enhance disaster resilience of highway transportation systems.

DOT National Transportation Integrated Search

2014-07-01

This study evaluated the resilience of highway bridges under the multihazard scenario of earthquake in the presence of : flood-induced scour. To mitigate losses incurred from bridge damage during extreme events, bridge retrofit strategies are : selec...

Under the hood of statistical learning: A statistical MMN reflects the magnitude of transitional probabilities in auditory sequences.

PubMed

Koelsch, Stefan; Busch, Tobias; Jentschke, Sebastian; Rohrmeier, Martin

2016-02-02

Within the framework of statistical learning, many behavioural studies investigated the processing of unpredicted events. However, surprisingly few neurophysiological studies are available on this topic, and no statistical learning experiment has investigated electroencephalographic (EEG) correlates of processing events with different transition probabilities. We carried out an EEG study with a novel variant of the established statistical learning paradigm. Timbres were presented in isochronous sequences of triplets. The first two sounds of all triplets were equiprobable, while the third sound occurred with either low (10%), intermediate (30%), or high (60%) probability. Thus, the occurrence probability of the third item of each triplet (given the first two items) was varied. Compared to high-probability triplet endings, endings with low and intermediate probability elicited an early anterior negativity that had an onset around 100 ms and was maximal at around 180 ms. This effect was larger for events with low than for events with intermediate probability. Our results reveal that, when predictions are based on statistical learning, events that do not match a prediction evoke an early anterior negativity, with the amplitude of this mismatch response being inversely related to the probability of such events. Thus, we report a statistical mismatch negativity (sMMN) that reflects statistical learning of transitional probability distributions that go beyond auditory sensory memory capabilities.

Flow performance in MPD at NICA

NASA Astrophysics Data System (ADS)

Svintsov, I. A.; Parfenov, P. E.; Selyuzhenkov, I. V.; Taranenko, A. V.

2017-01-01

The Nuclotron-based Ion Collider facility (NICA) in Dubna, Russia is currently under construction at the Joint Institute for Nuclear Research (JINR). A Multi Purpose Detector (MPD) at NICA is designed to study properties of baryonic dense matter in the range of center of mass collision energy from 4 to 11 GeV. We present a performance study for anisotropic transverse flow measurement in Au+Au collisions using the UrQMD event generator and Geant4 simulation of the MPD response. The collision symmetry plane is estimated from event-by-event transverse energy distribution in Forward Hadron Calorimeters (FHCal’s). Performance of the MPD for a measurement of the directed (v 1) and elliptic (v 2) flow of identified charged hadrons is evaluated based on comparison between reconstructed v 1 and v 2 values and the input one from the UrQMD model.

Episodic inputs of atmospheric nitrogen to the Sargasso Sea: Contributions to new production and phytoplankton blooms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michaels, A.F.; Johnson, R.J.; Siegel, D.A.

1993-06-01

This paper compares a recent atmospheric wet deposition record (including all measurable daily rainfall events between October 1988 and June 1991) with concurrent measurements of nitrogen cycling and biomass at the U.S. Joint Global Ocean Flux Study Bermuda Atlantic Time Series Study station. The two data sets, among the most complete synoptic records of atmospheric nitrogen deposition and ocean nitrogen cycling, provide an opportunity to directly assess the importance of nitrogen deposition in the ocean. The results indicate that individual nitrogen wet deposition events are usually small compared to the ambient nitrogen cycle and that only under sustained calm conditionsmore » following large deposition events will nitrogen deposition processes be an important signal for the understanding of ocean biochemistry. 46 refs., 7 figs.« less

Using multiple cause-of-death data to investigate associations and causality between conditions listed on the death certificate.

PubMed

Redelings, Matthew D; Wise, Matthew; Sorvillo, Frank

2007-07-01

Death rarely results from only one cause, and it can be caused by a variety of factors. Multiple cause-of-death data files can list as many as 20 contributing causes of death in addition to the reported underlying cause of death. Analysis of multiple cause-of-death data can provide information on associations between causes of death, revealing common combinations of events or conditions which lead to death. Additionally, physicians report the causal train of events through which they believe that different conditions or events may have led to each other and ultimately caused death. In this paper, the authors discuss methods used in studying associations between reported causes of death and in investigating commonly reported causal pathways between events or conditions listed on the death certificate.

Study of non-thermal photon production under different scenarios in solar flares. 2: The Compton inverse and Bremsstrahlung models and fittings

NASA Technical Reports Server (NTRS)

Perez-Peraza, J.; Alvarez, M.; Laville, A.; Gallegos, A.

1985-01-01

Energy spectra of photons emitted from Bremsstrahlung (BR) of energetic electrons with matter, is obtained from the deconvolution of the electron energy spectra. It can be inferred that the scenario for the production of X-rays and gamma rays in solar flares may vary from event to event. However, it is possible in many cases to associated low energy events to impulsive acceleration, and the high energy phase of some events to stochastic acceleration. In both cases, flare particles seem to be strongly modulated by local energy losses. Electric field acceleration, associated to neutral current sheets is a suitable candidate for impulsive acceleration. Finally, that the predominant radiation process of this radiation is the inverse Compton effect due to the local flare photon field.

Runoff and soil erosion of field plots in a subtropical mountainous region of China

NASA Astrophysics Data System (ADS)

Fang, N. F.; Wang, L.; Shi, Z. H.

2017-09-01

Anthropogenic pressure coupled with strong precipitation events and a mountainous landscape have led to serious soil erosion and associated problems in the subtropical climate zone of China. This study analyzes 1576 rainfall-runoff-soil loss events at 36 experimental plots (a total of 148 plot-years of data) under a wide range of conditions in subtropical mountainous areas of China where slope farming is commonly practiced. The plots, which have standardized dimensions, represent five common types of land use and have four different slopes. Event-based analyses show that almost half of the total rainfall caused soil erosion in the study area. The dominant factor controlling the runoff coefficient is the slope gradient rather than the land use type. The maximum soil lossfor crop plots under steep tillage (35°) is 5004 t km-2 for a single event. Among the common local crops, the average soil loss values increase in the following order: buckwheat < mung bean < sesame. Among the most widespread grasses, orchards and crops, the soil loss increase in the following order: red clover < nectarine < orange < maize. A large proportion of the soil loss is caused by a small number of extreme events. The annual average soil loss of the 44 plots ranges from 19 to 4090 t km-2 year-1. The annual soil loss of plots of different land use types decrease in the following order: bare land (1533 t km-2 year-1) > cropland (1179 t km-2 year-1) > terraced cropland (1083 t km-2 year-1) > orchard land (1020 t km-2 year-1) > grassland (762 t km-2 year-1) > terraced orchard land (297 t km-2 year-1) > forest and grassland (281 t km-2 year-1).

Estradiol enhances retention but not organization of hippocampus-dependent memory in intact male mice.

PubMed

Al Abed, Alice Shaam; Sellami, Azza; Brayda-Bruno, Laurent; Lamothe, Valérie; Noguès, Xavier; Potier, Mylène; Bennetau-Pelissero, Catherine; Marighetto, Aline

2016-07-01

Because estrogens have mostly been studied in gonadectomized females, effects of chronic exposure to environmental estrogens in the general population are underestimated. Estrogens can enhance hippocampus-dependent memory through the modulation of information storage. However, declarative memory, the hippocampus-dependent memory of facts and events, demands more than abilities to retain information. Specifically, memory of repetitive events of everyday life such as "where I parked" requires abilities to organize/update memories to prevent proactive interference from similar memories of previous "parking events". Whether such organizational processes are estrogen-sensitive is unknown. We here studied, in intact young and aged adult mice, drinking-water (1μM) estradiol effects on both retention and organizational components of hippocampus-dependent memory, using a radial-maze task of everyday-like memory. Demand on retention vs organization was manipulated by varying the time-interval separating repetitions of similar events. Estradiol increased performance in young and aged mice under minimized organizational demand, but failed to improve the age-associated memory impairment and diminished performance in young mice under high organizational demand. In fact, estradiol prolonged mnemonic retention of successive events without improving organization abilities, hence resulted in more proactive interference from irrelevant memories. c-Fos imaging of testing-induced brain activations showed that the deterioration of young memory was associated with dentate gyrus dysconnectivity, reminiscent of that seen in aged mice. Our findings support the view that estradiol is promnesic but also reveal that such property can paradoxically impair memory. These findings have important outcomes regarding health issues relative to the impact of environmental estrogens in the general population. Copyright © 2016 Elsevier Ltd. All rights reserved.

Method and apparatus for single-stepping coherence events in a multiprocessor system under software control

DOEpatents

Blumrich, Matthias A.; Salapura, Valentina

2010-11-02

An apparatus and method are disclosed for single-stepping coherence events in a multiprocessor system under software control in order to monitor the behavior of a memory coherence mechanism. Single-stepping coherence events in a multiprocessor system is made possible by adding one or more step registers. By accessing these step registers, one or more coherence requests are processed by the multiprocessor system. The step registers determine if the snoop unit will operate by proceeding in a normal execution mode, or operate in a single-step mode.

Bias correction of risk estimates in vaccine safety studies with rare adverse events using a self-controlled case series design.

PubMed

Zeng, Chan; Newcomer, Sophia R; Glanz, Jason M; Shoup, Jo Ann; Daley, Matthew F; Hambidge, Simon J; Xu, Stanley

2013-12-15

The self-controlled case series (SCCS) method is often used to examine the temporal association between vaccination and adverse events using only data from patients who experienced such events. Conditional Poisson regression models are used to estimate incidence rate ratios, and these models perform well with large or medium-sized case samples. However, in some vaccine safety studies, the adverse events studied are rare and the maximum likelihood estimates may be biased. Several bias correction methods have been examined in case-control studies using conditional logistic regression, but none of these methods have been evaluated in studies using the SCCS design. In this study, we used simulations to evaluate 2 bias correction approaches-the Firth penalized maximum likelihood method and Cordeiro and McCullagh's bias reduction after maximum likelihood estimation-with small sample sizes in studies using the SCCS design. The simulations showed that the bias under the SCCS design with a small number of cases can be large and is also sensitive to a short risk period. The Firth correction method provides finite and less biased estimates than the maximum likelihood method and Cordeiro and McCullagh's method. However, limitations still exist when the risk period in the SCCS design is short relative to the entire observation period.

Specialist Cohort Event Monitoring studies: a new study method for risk management in pharmacovigilance.

PubMed

Layton, Deborah; Shakir, Saad A W

2015-02-01

The evolving regulatory landscape has heightened the need for innovative, proactive, efficient and more meaningful solutions for 'real-world' post-authorization safety studies (PASS) that not only align with risk management objectives to gather additional safety monitoring information or assess a pattern of drug utilization, but also satisfy key regulatory requirements for marketing authorization holder risk management planning and execution needs. There is a need for data capture across the primary care and secondary care interface, or for exploring use of new medicines in secondary care to support conducting PASS. To fulfil this need, event monitoring has evolved. The Specialist Cohort Event Monitoring (SCEM) study is a new application that enables a cohort of patients prescribed a medicine in the hospital and secondary care settings to be monitored. The method also permits the inclusion of a comparator cohort of patients receiving standard care, or another counterfactual comparator group, to be monitored concurrently, depending on the study question. The approach has been developed in parallel with the new legislative requirement for pharmaceutical companies to undertake a risk management plan as part of post-authorization safety monitoring. SCEM studies recognize that the study population comprises those patients who may have treatment initiated under the care of specialist health care professionals and who are more complex in terms of underlying disease, co-morbidities and concomitant medications than the general disease population treated in primary care. The aims of this paper are to discuss the SCEM new-user study design, rationale and features that aim to address possible bias (such as selection bias) and current applications.

10 CFR 950.14 - Standby Support Contract: Covered events, exclusions, covered delay and covered cost provisions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... include a provision setting forth the type of events that are covered events under the contract. The type...) Litigation in State, Federal, local, or tribal courts, including appeals of Commission decisions related to..., including but not limited to the following types of events: (i) The sponsor's failure to comply with...

10 CFR 73.71 - Reporting of safeguards events.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 2 2014-01-01 2014-01-01 false Reporting of safeguards events. 73.71 Section 73.71 Energy... § 73.71 Reporting of safeguards events. (a)(1) Each licensee subject to the provisions of §§ 73.25, 73... revised information. Each licensee shall maintain a copy of the written report of an event submitted under...

30 CFR 773.13 - Unanticipated events or conditions at remining sites.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Unanticipated events or conditions at remining... events or conditions at remining sites. (a) You, the applicant, are eligible for a permit under § 773.12... event or condition at a surface coal mining and reclamation operation on lands that are eligible for...

30 CFR 773.13 - Unanticipated events or conditions at remining sites.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Unanticipated events or conditions at remining... events or conditions at remining sites. (a) You, the applicant, are eligible for a permit under § 773.12... event or condition at a surface coal mining and reclamation operation on lands that are eligible for...

30 CFR 773.13 - Unanticipated events or conditions at remining sites.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 3 2012-07-01 2012-07-01 false Unanticipated events or conditions at remining... events or conditions at remining sites. (a) You, the applicant, are eligible for a permit under § 773.12... event or condition at a surface coal mining and reclamation operation on lands that are eligible for...

10 CFR 73.71 - Reporting of safeguards events.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 2 2012-01-01 2012-01-01 false Reporting of safeguards events. 73.71 Section 73.71 Energy... § 73.71 Reporting of safeguards events. (a)(1) Each licensee subject to the provisions of §§ 73.25, 73... revised information. Each licensee shall maintain a copy of the written report of an event submitted under...

10 CFR 73.71 - Reporting of safeguards events.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 2 2013-01-01 2013-01-01 false Reporting of safeguards events. 73.71 Section 73.71 Energy... § 73.71 Reporting of safeguards events. (a)(1) Each licensee subject to the provisions of §§ 73.25, 73... revised information. Each licensee shall maintain a copy of the written report of an event submitted under...

30 CFR 773.13 - Unanticipated events or conditions at remining sites.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Unanticipated events or conditions at remining... events or conditions at remining sites. (a) You, the applicant, are eligible for a permit under § 773.12... event or condition at a surface coal mining and reclamation operation on lands that are eligible for...

30 CFR 773.13 - Unanticipated events or conditions at remining sites.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 3 2013-07-01 2013-07-01 false Unanticipated events or conditions at remining... events or conditions at remining sites. (a) You, the applicant, are eligible for a permit under § 773.12... event or condition at a surface coal mining and reclamation operation on lands that are eligible for...

78 FR 62719 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing of Advance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... Article VIII of its By-Laws and Rule 1104(b). The amount available under the New Facility at any given.... Events of default by OCC under the New Facility include, but are not limited to, non-payment of principal... outstanding; material inaccuracy of representations and warranties; bankruptcy events; fundamental changes...

75 FR 30036 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

....282(a)(1)(i) through (a)(1)(iii)). In the event that an article of food has been refused admission... in a request for review. In the event that an article of food has been placed under hold under...] Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment...

Measurement of charged-particle distributions sensitive to the underlying event in $$ \\sqrt{s}=13 $$ TeV proton-proton collisions with the ATLAS detector at the LHC

DOE PAGES

Aaboud, M.; Aad, G.; Abbott, B.; ...

2017-03-29

We present charged-particle distributions sensitive to the underlying event, measured by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV, in low-luminosity Large Hadron Collider fills corresponding to an integrated luminosity of 1.6 nb –1. The distributions were constructed using charged particles with absolute pseudorapidity less than 2.5 and with transverse momentum greater than 500 MeV, in events with at least one such charged particle with transverse momentum above 1 GeV. These distributions characterise the angular distribution of energy and particle flows with respect to the charged particle with highest transverse momentum, as a function ofmore » both that momentum and of charged-particle multiplicity. The results have been corrected for detector effects and are compared to the predictions of various Monte Carlo event generators, experimentally establishing the level of underlying-event activity at LHC Run 2 energies and providing inputs for the development of event generator modelling. The current models in use for UE modelling typically describe this data to 5% accuracy, compared with data uncertainties of less than 1%.« less

Measurement of charged-particle distributions sensitive to the underlying event in $$ \\sqrt{s}=13 $$ TeV proton-proton collisions with the ATLAS detector at the LHC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaboud, M.; Aad, G.; Abbott, B.

We present charged-particle distributions sensitive to the underlying event, measured by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV, in low-luminosity Large Hadron Collider fills corresponding to an integrated luminosity of 1.6 nb –1. The distributions were constructed using charged particles with absolute pseudorapidity less than 2.5 and with transverse momentum greater than 500 MeV, in events with at least one such charged particle with transverse momentum above 1 GeV. These distributions characterise the angular distribution of energy and particle flows with respect to the charged particle with highest transverse momentum, as a function ofmore » both that momentum and of charged-particle multiplicity. The results have been corrected for detector effects and are compared to the predictions of various Monte Carlo event generators, experimentally establishing the level of underlying-event activity at LHC Run 2 energies and providing inputs for the development of event generator modelling. The current models in use for UE modelling typically describe this data to 5% accuracy, compared with data uncertainties of less than 1%.« less

How Brooding Minds Inhibit Negative Material: An Event-Related fMRI Study

ERIC Educational Resources Information Center

Vanderhasselt, Marie-Anne; Baeken, Chris; Van Schuerbeek, Peter; Luypaert, Rob; De Mey, Johan; De Raedt, Rudi

2013-01-01

Depressive brooding--a passive ruminative focus on one's problems, negative mood and their consequences--is a thinking style that places individuals at a greater risk to develop future psychopathology. In this study, we investigated whether inter-individual differences in depressive brooding are related to neural differences underlying the…

Behavioral responses of freshwater mussels to experimental dewatering

USGS Publications Warehouse

Galbraith, Heather S.; Blakeslee, Carrie J.; Lellis, William A.

2015-01-01

Understanding the effects of flow alteration on freshwater ecosystems is critical for predicting species responses and restoring appropriate flow regimes. We experimentally evaluated the effects of 3 dewatering rates on behavior of 6 freshwater mussel species in the context of water-removal rates observed in 21 Atlantic Coast rivers. Horizontal movement differed significantly among species and dewatering rates, but a significant species × dewatering interaction suggested that these factors influence movement in complex ways. Species differences in movement were evident only in controls and under slow dewatering rates, but these differences disappeared at moderate and fast dewatering rates. Burrowing behavior did not differ with respect to species identity or dewatering rate. The proportion of individuals that became stranded did not differ among species, but most individuals became stranded under low and moderate dewatering, and all individuals became stranded under fast dewatering. Mortality after stranding differed strongly among species along a gradient from 25% inPyganodon cataracta to 92% in Alasmidonta marginata. Together, these results suggest that species behavior may differ under gradual dewatering, but all species in our study are poorly adapted for rapid dewatering. Most of the 21 rivers we assessed experienced dewatering events comparable to our moderate rate, and several experienced events comparable to our fast rate. Dewatering events that exceed the movement or survival capability of most mussel species can be expected to result in assemblage-wide impacts. Consequently, the rate of water level change may be important in refining target flow conditions for restoration.

Local instability driving extreme events in a pair of coupled chaotic electronic circuits

NASA Astrophysics Data System (ADS)

de Oliveira, Gilson F.; Di Lorenzo, Orlando; de Silans, Thierry Passerat; Chevrollier, Martine; Oriá, Marcos; Cavalcante, Hugo L. D. de Souza

2016-06-01

For a long time, extreme events happening in complex systems, such as financial markets, earthquakes, and neurological networks, were thought to follow power-law size distributions. More recently, evidence suggests that in many systems the largest and rarest events differ from the other ones. They are dragon kings, outliers that make the distribution deviate from a power law in the tail. Understanding the processes of formation of extreme events and what circumstances lead to dragon kings or to a power-law distribution is an open question and it is a very important one to assess whether extreme events will occur too often in a specific system. In the particular system studied in this paper, we show that the rate of occurrence of dragon kings is controlled by the value of a parameter. The system under study here is composed of two nearly identical chaotic oscillators which fail to remain in a permanently synchronized state when coupled. We analyze the statistics of the desynchronization events in this specific example of two coupled chaotic electronic circuits and find that modifying a parameter associated to the local instability responsible for the loss of synchronization reduces the occurrence of dragon kings, while preserving the power-law distribution of small- to intermediate-size events with the same scaling exponent. Our results support the hypothesis that the dragon kings are caused by local instabilities in the phase space.

A model for the perception of environmental sound based on notice-events.

PubMed

De Coensel, Bert; Botteldooren, Dick; De Muer, Tom; Berglund, Birgitta; Nilsson, Mats E; Lercher, Peter

2009-08-01

An approach is proposed to shed light on the mechanisms underlying human perception of environmental sound that intrudes in everyday living. Most research on exposure-effect relationships aims at relating overall effects to overall exposure indicators in an epidemiological fashion, without including available knowledge on the possible underlying mechanisms. Here, it is proposed to start from available knowledge on audition and perception to construct a computational framework for the effect of environmental sound on individuals. Obviously, at the individual level additional mechanisms (inter-sensory, attentional, cognitive, emotional) play a role in the perception of environmental sound. As a first step, current knowledge is made explicit by building a model mimicking some aspects of human auditory perception. This model is grounded in the hypothesis that long-term perception of environmental sound is determined primarily by short notice-events. The applicability of the notice-event model is illustrated by simulating a synthetic population exposed to typical Flemish environmental noise. From these simulation results, it is demonstrated that the notice-event model is able to mimic the differences between the annoyance caused by road traffic noise exposure and railway traffic noise exposure that are also observed empirically in other studies and thus could provide an explanation for these differences.

A Single Hot Event That Does Not Affect Survival but Decreases Reproduction in the Diamondback Moth, Plutella xylostella

PubMed Central

Zhang, Wei; Zhao, Fei; Hoffmann, Ary A.; Ma, Chun-Sen

2013-01-01

Extremely hot events (usually involving a few hours at extreme high temperatures in summer) are expected to increase in frequency in temperate regions under global warming. The impact of these events is generally overlooked in insect population prediction, since they are unlikely to cause widespread mortality, however reproduction may be affected by them. In this study, we examined such stress effects in the diamondback moth, Plutella xylostella. We simulated a single extreme hot day (maximum of 40°C lasting for 3, 4 or 5 h) increasingly experienced under field conditions. This event had no detrimental effects on immediate mortality, copulation duration, mating success, longevity or lifetime fecundity, but stressed females produced 21% (after 3 or 4 h) fewer hatched eggs because of a decline in the number and hatching success of eggs laid on the first two days. These negative effects on reproduction were no longer evident in the following days. Male heat exposure led to a similar but smaller effect on fertile egg production, and exposure extended pre-mating period in both sexes. Our results indicate that a single hot day can have detrimental effects on reproduction, particularly through maternal effects on egg hatching, and thereby influence the population dynamics of diamondback moth. PMID:24116081

Impact of repeated single-metal and multi-metal pollution events on soil quality.

PubMed

Burges, Aritz; Epelde, Lur; Garbisu, Carlos

2015-02-01

Most frequently, soil metal pollution results from the occurrence of repeated single-metal and, above all, multi-metal pollution events, with concomitant adverse consequences for soil quality. Therefore, in this study, we evaluated the impact of repeated single-metal and multi-metal (Cd, Pb, Cu, Zn) pollution events on soil quality, as reflected by the values of a variety of soil microbial parameters with potential as bioindicators of soil functioning. Specifically, parameters of microbial activity (potentially mineralizable nitrogen, β-glucosidase and acid phosphatase activity) and biomass (fungal and bacterial gene abundance by RT-qPCR) were determined, in the artificially metal-polluted soil samples, at regular intervals over a period of 26 weeks. Similarly, we studied the evolution over time of CaCl2-extractable metal fractions, in order to estimate metal bioavailability in soil. Different metals showed different values of bioavailability and relative bioavailability ([metal]bio/[metal]tot) in soil throughout the experiment, under both repeated single-metal and multi-metal pollution events. Both repeated Zn-pollution and multi-metal pollution events led to a significant reduction in the values of acid phosphatase activity, and bacterial and fungal gene abundance, reflecting the negative impact of these repeated events on soil microbial activity and biomass, and, hence, soil quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

Safety and utility of magnetic resonance imaging in patients with cardiac implantable electronic devices.

PubMed

Strom, Jordan B; Whelan, Jill B; Shen, Changyu; Zheng, Shuang Qi; Mortele, Koenraad J; Kramer, Daniel B

2017-08-01

Off-label magnetic resonance imaging (MRI) for patients with cardiac implantable electrical devices has been limited owing to concerns about safety and unclear diagnostic and prognostic utility. The purpose of this study was to define major and minor adverse events with off-label MRI scans. We prospectively evaluated patients with non-MRI-conditional cardiac implantable electrical devices referred for MRI scans under a strict clinical protocol. The primary safety outcome was incidence of major adverse events (loss of pacing, inappropriate shock or antitachycardia pacing, need for system revision, or death) or minor adverse events (inappropriate pacing, arrhythmias, power-on-reset events, heating at the generator site, or changes in device parameters at baseline or at 6 months). A total of 189 MRI scans were performed in 123 patients (63.1% [78] men; median age 70 ± 18.5 years; 56.9% [70] patients with implantable cardioverter-defibrillators; 33.3% [41] pacemaker-dependent patients) predominantly for brain or spinal conditions. A minority of scans (22.7% [43]) were performed for urgent or emergent indications. Major adverse events were rare: 1 patient with loss of pacing, no deaths, or system revisions (overall rate 0.5%; 95% confidence interval 0.01-2.91). Minor adverse events were similarly rare (overall rate 1.6%; 95% confidence interval 0.3-4.6). Nearly all studies (98.4% [186]) were interpretable, while 75.1% [142] were determined to change management according to the prespecified criteria. No clinically significant changes were observed in device parameters acutely after MRI or at 6 months as compared with baseline across all patient and device categories. Off-label MRI scans performed under a strict protocol demonstrated excellent short- and medium-term safety while providing interpretable imaging that frequently influenced clinical care. Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Event Rate for LISA Gravitational Wave Signals from Black Hole-Massive Black Hole Coalescences

NASA Technical Reports Server (NTRS)

Bender, Peter L.

2002-01-01

Earlier work under a previous grant had been mainly on investigating the event rate for coalescences of white dwarfs or neutron stars with massive black holes (MBHs) in galactic nuclei. Under the new grant, two studies were undertaken. One was an approximate extension of the earlier study to stellar mass black holes as the lighter object, with masses in the range of roughly 3 to 20 solar mass rather than about 1 solar mass. The other was an improved estimate of the confusion noise due to galactic binaries against which the signals from BH-MBH coalescences would have to be detected. In the earlier work, the mass of the white dwarfs (WDs) and neutron stars (NSs) was assumed to be about the same as that of the evolved stars in the density cusp around the galactic center MBH. However, with the BH mass being substantially larger, the sinking down of pHs toward the center (mass segregation) became important, and was included in the model. A single representative mass of 7 solar mass was used. The other main difference involved what happened after the compact object got scattered in close enough to the MBH to start losing appreciable energy and angular momentum by gravitational radiation. For WDs or NSs, it had been found in most cases that the object would be perturbed considerably by other stars in the cusp before much energy had been lost. Thus the angular momentum would either increase enough so that gravitational radiation would be cut off, or would decrease enough so that the WD or NS would plunge into the MBH in just a few revolutions. The latter event would mean that the signal-to noise ratio would not have time to build up, and the event would not be detectable. The ratio of gradual energy loss events to plunges was found to be roughly one to a few percent, and thus substantially decreased the expected rate of detectable events.

Safety and utility of magnetic resonance imaging in patients with cardiac implantable electronic devices

PubMed Central

Strom, Jordan B.; Whelan, Jill B.; Shen, Changyu; Zheng, Shuang Qi; Mortele, Koenraad J.; Kramer, Daniel B.

2017-01-01

BACKGROUND Off-label magnetic resonance imaging (MRI) for patients with cardiac implantable electrical devices has been limited owing to concerns about safety and unclear diagnostic and prognostic utility. OBJECTIVE The purpose of this study was to define major and minor adverse events with off-label MRI scans. METHODS We prospectively evaluated patients with non–MRI-conditional cardiac implantable electrical devices referred for MRI scans under a strict clinical protocol. The primary safety outcome was incidence of major adverse events (loss of pacing, inappropriate shock or antitachycardia pacing, need for system revision, or death) or minor adverse events (inappropriate pacing, arrhythmias, power-on-reset events, heating at the generator site, or changes in device parameters at baseline or at 6 months). RESULTS A total of 189 MRI scans were performed in 123 patients (63.1% [78] men; median age 70 ± 18.5 years; 37.0% [70] patients with implantable cardioverter-defibrillators; 21.8% [41] pacemaker-dependent patients) predominantly for brain or spinal conditions. A minority of scans (22.7% [43]) were performed for urgent or emergent indications. Major adverse events were rare: 1 patient with loss of pacing, no deaths, or system revisions (overall rate 0.5%; 95% confidence interval 0.01–2.91). Minor adverse events were similarly rare (overall rate 1.6%; 95% confidence interval 0.3–4.6). Nearly all studies (98.4% [186]) were interpretable, while 74.9% [142] were determined to change management according to the prespecified criteria. No clinically significant changes were observed in device parameters acutely after MRI or at 6 months as compared with baseline across all patient and device categories. CONCLUSION Off-label MRI scans performed under a strict protocol demonstrated excellent short- and medium-term safety while providing interpretable imaging that frequently influenced clinical care. PMID:28385671

Limiting global warming to 2°C is unlikely to save most coral reefs

NASA Astrophysics Data System (ADS)

Frieler, K.; Meinshausen, M.; Golly, A.; Mengel, M.; Lebek, K.; Donner, S. D.; Hoegh-Guldberg, O.

2013-02-01

Mass coral bleaching events have become a widespread phenomenon causing serious concerns with regard to the survival of corals. Triggered by high ocean temperatures, bleaching events are projected to increase in frequency and intensity. Here, we provide a comprehensive global study of coral bleaching in terms of global mean temperature change, based on an extended set of emissions scenarios and models. We show that preserving >10% of coral reefs worldwide would require limiting warming to below 1.5°C (atmosphere-ocean general circulation models (AOGCMs) range: 1.3-1.8°C) relative to pre-industrial levels. Even under optimistic assumptions regarding corals' thermal adaptation, one-third (9-60%, 68% uncertainty range) of the world's coral reefs are projected to be subject to long-term degradation under the most optimistic new IPCC emissions scenario, RCP3-PD. Under RCP4.5 this fraction increases to two-thirds (30-88%, 68% uncertainty range). Possible effects of ocean acidification reducing thermal tolerance are assessed within a sensitivity experiment.

Measuring Aggregation of Events about a Mass Using Spatial Point Pattern Methods

PubMed Central

Smith, Michael O.; Ball, Jackson; Holloway, Benjamin B.; Erdelyi, Ferenc; Szabo, Gabor; Stone, Emily; Graham, Jonathan; Lawrence, J. Josh

2017-01-01

We present a methodology that detects event aggregation about a mass surface using 3-dimensional study regions with a point pattern and a mass present. The Aggregation about a Mass function determines aggregation, randomness, or repulsion of events with respect to the mass surface. Our method closely resembles Ripley’s K function but is modified to discern the pattern about the mass surface. We briefly state the definition and derivation of Ripley’s K function and explain how the Aggregation about a Mass function is different. We develop the novel function according to the definition: the Aggregation about a Mass function times the intensity is the expected number of events within a distance h of a mass. Special consideration of edge effects is taken in order to make the function invariant to the location of the mass within the study region. Significance of aggregation or repulsion is determined using simulation envelopes. A simulation study is performed to inform researchers how the Aggregation about a Mass function performs under different types of aggregation. Finally, we apply the Aggregation about a Mass function to neuroscience as a novel analysis tool by examining the spatial pattern of neurotransmitter release sites as events about a neuron. PMID:29046865

Nogales flood detention study

USGS Publications Warehouse

Norman, Laura M.; Levick, Lainie; Guertin, D. Phillip; Callegary, James; Guadarrama, Jesus Quintanar; Anaya, Claudia Zulema Gil; Prichard, Andrea; Gray, Floyd; Castellanos, Edgar; Tepezano, Edgar; Huth, Hans; Vandervoet, Prescott; Rodriguez, Saul; Nunez, Jose; Atwood, Donald; Granillo, Gilberto Patricio Olivero; Ceballos, Francisco Octavio Gastellum

2010-01-01

Flooding in Ambos Nogales often exceeds the capacity of the channel and adjacent land areas, endangering many people. The Nogales Wash is being studied to prevent future flood disasters and detention features are being installed in tributaries of the wash. This paper describes the application of the KINEROS2 model and efforts to understand the capacity of these detention features under various flood and urbanization scenarios. Results depict a reduction in peak flow for the 10-year, 1-hour event based on current land use in tributaries with detention features. However, model results also demonstrate that larger storm events and increasing urbanization will put a strain on the features and limit their effectiveness.

Modelling the occurrence of heat waves in maximum and minimum temperatures over Spain and projections for the period 2031-60

NASA Astrophysics Data System (ADS)

Abaurrea, J.; Asín, J.; Cebrián, A. C.

2018-02-01

The occurrence of extreme heat events in maximum and minimum daily temperatures is modelled using a non-homogeneous common Poisson shock process. It is applied to five Spanish locations, representative of the most common climates over the Iberian Peninsula. The model is based on an excess over threshold approach and distinguishes three types of extreme events: only in maximum temperature, only in minimum temperature and in both of them (simultaneous events). It takes into account the dependence between the occurrence of extreme events in both temperatures and its parameters are expressed as functions of time and temperature related covariates. The fitted models allow us to characterize the occurrence of extreme heat events and to compare their evolution in the different climates during the observed period. This model is also a useful tool for obtaining local projections of the occurrence rate of extreme heat events under climate change conditions, using the future downscaled temperature trajectories generated by Earth System Models. The projections for 2031-60 under scenarios RCP4.5, RCP6.0 and RCP8.5 are obtained and analysed using the trajectories from four earth system models which have successfully passed a preliminary control analysis. Different graphical tools and summary measures of the projected daily intensities are used to quantify the climate change on a local scale. A high increase in the occurrence of extreme heat events, mainly in July and August, is projected in all the locations, all types of event and in the three scenarios, although in 2051-60 the increase is higher under RCP8.5. However, relevant differences are found between the evolution in the different climates and the types of event, with a specially high increase in the simultaneous ones.

Fatigue Is a Predictor for Cardiovascular Outcomes in Patients Undergoing Hemodialysis

PubMed Central

Fukuda, Sanae; Shoji, Tetsuo; Inaba, Masaaki; Tsujimoto, Yoshihiro; Tabata, Tsutomu; Okuno, Senji; Yamakawa, Tomoyuki; Okada, Shigeki; Okamura, Mikio; Kuratsune, Hirohiko; Fujii, Hisako; Hirayama, Yoshinobu; Watanabe, Yasuyoshi; Nishizawa, Yoshiki

2010-01-01

Background and objectives: Despite potential significance of fatigue and its underlying components in the occurrence of cardiovascular diseases, epidemiologic data showing the link are virtually limited. This study was designed to examine whether fatigue symptoms or fatigue's underlying components are a predictor for cardiovascular diseases in high-risk subjects with ESRD. Design, setting, participants, & measurements: 788 volunteer patients under hemodialysis therapy (506 male, 282 female) completed the survey between October and November 2005, with the follow-up period up to 26 months to monitor occurrence of fatal or nonfatal cardiovascular events. The questionnaire consisted of 64 questions, and promax rotation analysis of the principal component method conceptualized eight fatigue-related factors: fatigue itself, anxiety and depression, loss of attention and memory, pain, overwork, autonomic imbalance, sleep problems, and infection. Results: 14.7% of the patients showed fatigue scores higher than twice the SD of the mean for healthy volunteers. These highly fatigued patients exhibited a significantly higher risk for cardiovascular events (hazard ratio: 2.17; P < 0.01), with the relationship independent of the well-known risk factors, including age, diabetes, cardiovascular disease history, and inflammation and malnutrition markers. Moreover, comparisons of the risk in key subgroups showed that the risk of high fatigue score for cardiovascular events was more prominent in well-nourished patients, including lower age, absence of past cardiovascular diseases, higher serum albumin, and high non-HDL cholesterol. Conclusions: Fatigue can be an important predictor for cardiovascular events in patients with ESRD, with the relationship independent of the nutritional or inflammatory status. PMID:20185601

Rule-Based Event Processing and Reaction Rules

NASA Astrophysics Data System (ADS)

Paschke, Adrian; Kozlenkov, Alexander

Reaction rules and event processing technologies play a key role in making business and IT / Internet infrastructures more agile and active. While event processing is concerned with detecting events from large event clouds or streams in almost real-time, reaction rules are concerned with the invocation of actions in response to events and actionable situations. They state the conditions under which actions must be taken. In the last decades various reaction rule and event processing approaches have been developed, which for the most part have been advanced separately. In this paper we survey reaction rule approaches and rule-based event processing systems and languages.

Early disrupted neurovascular coupling and changed event level hemodynamic response function in type 2 diabetes: an fMRI study.

PubMed

Duarte, João V; Pereira, João M S; Quendera, Bruno; Raimundo, Miguel; Moreno, Carolina; Gomes, Leonor; Carrilho, Francisco; Castelo-Branco, Miguel

2015-10-01

Type 2 diabetes (T2DM) patients develop vascular complications and have increased risk for neurophysiological impairment. Vascular pathophysiology may alter the blood flow regulation in cerebral microvasculature, affecting neurovascular coupling. Reduced fMRI signal can result from decreased neuronal activation or disrupted neurovascular coupling. The uncertainty about pathophysiological mechanisms (neurodegenerative, vascular, or both) underlying brain function impairments remains. In this cross-sectional study, we investigated if the hemodynamic response function (HRF) in lesion-free brains of patients is altered by measuring BOLD (Blood Oxygenation Level-Dependent) response to visual motion stimuli. We used a standard block design to examine the BOLD response and an event-related deconvolution approach. Importantly, the latter allowed for the first time to directly extract the true shape of HRF without any assumption and probe neurovascular coupling, using performance-matched stimuli. We discovered a change in HRF in early stages of diabetes. T2DM patients show significantly different fMRI response profiles. Our visual paradigm therefore demonstrated impaired neurovascular coupling in intact brain tissue. This implies that functional studies in T2DM require the definition of HRF, only achievable with deconvolution in event-related experiments. Further investigation of the mechanisms underlying impaired neurovascular coupling is needed to understand and potentially prevent the progression of brain function decrements in diabetes.

Plasticity of Total and Intracellular Phosphorus Quotas in Microcystis aeruginosa Cultures and Lake Erie Algal Assemblages

PubMed Central

Saxton, Matthew A.; Arnold, Robert J.; Bourbonniere, Richard A.; McKay, Robert Michael L.; Wilhelm, Steven W.

2011-01-01

Blooms of the potentially toxic cyanobacterium Microcystis are common events globally, and as a result significant resources continue to be dedicated to monitoring and controlling these events. Recent studies have shown that a significant proportion of total cell-associated phosphorus (P) in marine phytoplankton can be surface adsorbed; as a result studies completed to date do not accurately report the P demands of these organisms. In this study we measure the total cell-associated and intracellular P as well as growth rates of two toxic strains of Microcystis aeruginosa Kütz grown under a range of P concentrations. The results show that the intracellular P pool in Microcystis represents a percentage of total cell-associated P (50–90%) similar to what has been reported for actively growing algae in marine systems. Intracellular P concentrations (39–147 fg cell−1) generally increased with increasing P concentrations in the growth medium, but growth rate and the ratio of total cell-associated to intracellular P remained generally stable. Intracellular P quotas and growth rates in cells grown under the different P treatments illustrate the ability of this organism to successfully respond to changes in ambient P loads, and thus have implications for ecosystem scale productivity models employing P concentrations to predict algal bloom events. PMID:22279445

Shear Behaviour and Acoustic Emission Characteristics of Bolted Rock Joints with Different Roughnesses

NASA Astrophysics Data System (ADS)

Wang, Gang; Zhang, Yongzheng; Jiang, Yujing; Liu, Peixun; Guo, Yanshuang; Liu, Jiankang; Ma, Ming; Wang, Ke; Wang, Shugang

2018-06-01

To study shear failure, acoustic emission counts and characteristics of bolted jointed rock-like specimens are evaluated under compressive shear loading. Model joint surfaces with different roughnesses are made of rock-like material (i.e. cement). The jointed rock masses are anchored with bolts with different elongation rates. The characteristics of the shear mechanical properties, the failure mechanism, and the acoustic emission parameters of the anchored joints are studied under different surface roughnesses and anchorage conditions. The shear strength and residual strength increase with the roughness of the anchored joint surface. With an increase in bolt elongation, the shear strength of the anchored joint surface gradually decreases. When the anchored structural plane is sheared, the ideal cumulative impact curve can be divided into four stages: initial emission, critical instability, cumulative energy, and failure. With an increase in the roughness of the anchored joint surface, the peak energy rate and the cumulative number of events will also increase during macro-scale shear failure. With an increase in the bolt elongation, the energy rate and the event number increase during the shearing process. Furthermore, the peak energy rate, peak number of events and cumulative energy will all increase with the bolt elongation. The results of this study can provide guidance for the use of the acoustic emission technique in monitoring and predicting the static shear failure of anchored rock masses.

Updated Intensity - Duration - Frequency Curves Under Different Future Climate Scenarios

NASA Astrophysics Data System (ADS)

Ragno, E.; AghaKouchak, A.

2016-12-01

Current infrastructure design procedures rely on the use of Intensity - Duration - Frequency (IDF) curves retrieved under the assumption of temporal stationarity, meaning that occurrences of extreme events are expected to be time invariant. However, numerous studies have observed more severe extreme events over time. Hence, the stationarity assumption for extreme analysis may not be appropriate in a warming climate. This issue raises concerns regarding the safety and resilience of the existing and future infrastructures. Here we employ historical and projected (RCP 8.5) CMIP5 runs to investigate IDF curves of 14 urban areas across the United States. We first statistically assess changes in precipitation extremes using an energy-based test for equal distributions. Then, through a Bayesian inference approach for stationary and non-stationary extreme value analysis, we provide updated IDF curves based on climatic model projections. This presentation summarizes the projected changes in statistics of extremes. We show that, based on CMIP5 simulations, extreme precipitation events in some urban areas can be 20% more severe in the future, even when projected annual mean precipitation is expected to remain similar to the ground-based climatology.

Exploiting Language Models to Classify Events from Twitter

PubMed Central

Vo, Duc-Thuan; Hai, Vo Thuan; Ock, Cheol-Young

2015-01-01

Classifying events is challenging in Twitter because tweets texts have a large amount of temporal data with a lot of noise and various kinds of topics. In this paper, we propose a method to classify events from Twitter. We firstly find the distinguishing terms between tweets in events and measure their similarities with learning language models such as ConceptNet and a latent Dirichlet allocation method for selectional preferences (LDA-SP), which have been widely studied based on large text corpora within computational linguistic relations. The relationship of term words in tweets will be discovered by checking them under each model. We then proposed a method to compute the similarity between tweets based on tweets' features including common term words and relationships among their distinguishing term words. It will be explicit and convenient for applying to k-nearest neighbor techniques for classification. We carefully applied experiments on the Edinburgh Twitter Corpus to show that our method achieves competitive results for classifying events. PMID:26451139

Kelvin-Helmholtz instability: the ``atom'' of geophysical turbulence?

NASA Astrophysics Data System (ADS)

Smyth, William

2017-11-01

Observations of small-scale turbulence in Earth's atmosphere and oceans have most commonly been interpreted in terms of the Kolmogorov theory of isotropic turbulence, despite the fact that the observed turbulence is significantly anisotropic due to density stratification and sheared large-scale flows. I will describe an alternative picture in which turbulence consists of distinct events that occur sporadically in space and time. The simplest model for an individual event is the ``Kelvin-Helmholtz (KH) ansatz'', in which turbulence relieves the dynamic instability of a localized shear layer. I will summarize evidence that the KH ansatz is a valid description of observed turbulence events, using microstructure measurements from the equatorial Pacific ocean as an example. While the KH ansatz has been under study for many decades and is reasonably well understood, the bigger picture is much less clear. How are the KH events distributed in space and time? How do different events interact with each other? I will describe some tentative steps toward a more thorough understanding.

Emotional stressors trigger cardiovascular events.

PubMed

Schwartz, B G; French, W J; Mayeda, G S; Burstein, S; Economides, C; Bhandari, A K; Cannom, D S; Kloner, R A

2012-07-01

To describe the relation between emotional stress and cardiovascular events, and review the literature on the cardiovascular effects of emotional stress, in order to describe the relation, the underlying pathophysiology, and potential therapeutic implications. Targeted PUBMED searches were conducted to supplement the authors' existing database on this topic. Cardiovascular events are a major cause of morbidity and mortality in the developed world. Cardiovascular events can be triggered by acute mental stress caused by events such as an earthquake, a televised high-drama soccer game, job strain or the death of a loved one. Acute mental stress increases sympathetic output, impairs endothelial function and creates a hypercoagulable state. These changes have the potential to rupture vulnerable plaque and precipitate intraluminal thrombosis, resulting in myocardial infarction or sudden death. Therapies targeting this pathway can potentially prevent acute mental stressors from initiating plaque rupture. Limited evidence suggests that appropriately timed administration of beta-blockers, statins and aspirin might reduce the incidence of triggered myocardial infarctions. Stress management and transcendental meditation warrant further study. © 2012 Blackwell Publishing Ltd.

Analysis and Prediction of Exon Skipping Events from RNA-Seq with Sequence Information Using Rotation Forest.

PubMed

Du, Xiuquan; Hu, Changlin; Yao, Yu; Sun, Shiwei; Zhang, Yanping

2017-12-12

In bioinformatics, exon skipping (ES) event prediction is an essential part of alternative splicing (AS) event analysis. Although many methods have been developed to predict ES events, a solution has yet to be found. In this study, given the limitations of machine learning algorithms with RNA-Seq data or genome sequences, a new feature, called RS (RNA-seq and sequence) features, was constructed. These features include RNA-Seq features derived from the RNA-Seq data and sequence features derived from genome sequences. We propose a novel Rotation Forest classifier to predict ES events with the RS features (RotaF-RSES). To validate the efficacy of RotaF-RSES, a dataset from two human tissues was used, and RotaF-RSES achieved an accuracy of 98.4%, a specificity of 99.2%, a sensitivity of 94.1%, and an area under the curve (AUC) of 98.6%. When compared to the other available methods, the results indicate that RotaF-RSES is efficient and can predict ES events with RS features.

Synthetic drought event sets: thousands of meteorological drought events for risk-based management under present and future conditions

NASA Astrophysics Data System (ADS)

Guillod, Benoit P.; Massey, Neil; Otto, Friederike E. L.; Allen, Myles R.; Jones, Richard; Hall, Jim W.

2016-04-01

Droughts and related water scarcity can have large impacts on societies and consist of interactions between a number of natural and human factors. Meteorological conditions are usually the first natural trigger of droughts, and climate change is expected to impact these and thereby the frequency and intensity of the events. However, extreme events such as droughts are, by definition, rare, and accurately quantifying the risk related to such events is therefore difficult. The MaRIUS project (Managing the Risks, Impacts and Uncertainties of drought and water Scarcity) aims at quantifying the risks associated with droughts in the UK under present and future conditions. To do so, a large number of drought events, from climate model simulations downscaled at 25km over Europe, are being fed into hydrological models of various complexity and used for the estimation of drought risk associated with human and natural systems, including impacts on the economy, industry, agriculture, terrestrial and aquatic ecosystems, and socio-cultural aspects. Here, we present the hydro-meteorological drought event set that has been produced by weather@home [1] for MaRIUS. Using idle processor time on volunteers' computers around the world, we have run a very large number (10'000s) of Global Climate Model (GCM) simulations, downscaled at 25km over Europe by a nested Regional Climate Model (RCM). Simulations include the past 100 years as well as two future horizons (2030s and 2080s), and provide a large number of sequences of spatio-temporally consistent weather, which are consistent with the boundary forcing such as the ocean, greenhouse gases and solar forcing. The drought event set for use in impact studies is constructed by extracting sequences of dry conditions from these model runs, leading to several thousand drought events. In addition to describing methodological and validation aspects of the synthetic drought event sets, we provide insights into drought risk in the UK, its meteorological drivers, and how it can be expected to change in the future. Finally, we assess the applicability of this methodology to other regions. [1] Massey, N. et al., 2014, Q. J. R. Meteorol. Soc.

Event Water Balance and Recharge at the Panola Mountain Research Watershed, Georgia, U.S.A.

NASA Astrophysics Data System (ADS)

Riley, J. W.; Aulenbach, B. T.

2016-12-01

Investigating catchment storage and runoff pathways allows a better mechanistic understanding of stream flow generation processes. This information can be used to elucidate processes such as those influencing baseflow that support human consumption and ecological needs. Here we describe storm runoff water budgets from 483 rain events to determine the conditions under which precipitation infiltrates to deeper storage that supports baseflow. Further, we examine the storage and recharge behavior of different storm characteristics and antecedent conditions. We use a simple water budget approach to achieve this in which Deep Recharge = (Precipitation) - (Storm Runoff) - (Event Change in Soil Storage). Hydrograph separation was used to determine the storm periods and split storm runoff into baseflow and quickflow. Quickflow was assumed to account for the event water lost to the stream. Data from volumetric water content sensors were used to calculate the soil profile water storage and the change in water storage over the course of an event. The remaining water after these two components was assumed to represent water available for deeper recharge. The median event quickflow:precipitation ratio was 11.8%. Event soil moisture recharge in the top one meter of soil accounted for a median of 65.3% of precipitation. Quickflow and shallow soil moisture recharge accounted for a median of 77.1% of the precipitation delivered to the watershed. Water budgets indicated that 43% of the events provided water for deeper recharge. Of these events, however, only 28% provided 50 mm or more of deep recharge. Because the focus was on events, when humidity was high and the vapor pressure deficit (VPD) was low, we ignored the role of evapotranspiration. However, interception, which was not accounted for, would have resulted in less storm precipitation than was measured at the watershed rain gage. Furthermore, transpiration may have altered the post-storm water balance when VPD increased and before excess water was able to infiltrate to deeper storage. While uncertainty remains, this study provided insight into the partitioning of incoming precipitation and the conditions under which water was likely available for deeper recharge.

Maximizing Statistical Power When Verifying Probabilistic Forecasts of Hydrometeorological Events

NASA Astrophysics Data System (ADS)

DeChant, C. M.; Moradkhani, H.

2014-12-01

Hydrometeorological events (i.e. floods, droughts, precipitation) are increasingly being forecasted probabilistically, owing to the uncertainties in the underlying causes of the phenomenon. In these forecasts, the probability of the event, over some lead time, is estimated based on some model simulations or predictive indicators. By issuing probabilistic forecasts, agencies may communicate the uncertainty in the event occurring. Assuming that the assigned probability of the event is correct, which is referred to as a reliable forecast, the end user may perform some risk management based on the potential damages resulting from the event. Alternatively, an unreliable forecast may give false impressions of the actual risk, leading to improper decision making when protecting resources from extreme events. Due to this requisite for reliable forecasts to perform effective risk management, this study takes a renewed look at reliability assessment in event forecasts. Illustrative experiments will be presented, showing deficiencies in the commonly available approaches (Brier Score, Reliability Diagram). Overall, it is shown that the conventional reliability assessment techniques do not maximize the ability to distinguish between a reliable and unreliable forecast. In this regard, a theoretical formulation of the probabilistic event forecast verification framework will be presented. From this analysis, hypothesis testing with the Poisson-Binomial distribution is the most exact model available for the verification framework, and therefore maximizes one's ability to distinguish between a reliable and unreliable forecast. Application of this verification system was also examined within a real forecasting case study, highlighting the additional statistical power provided with the use of the Poisson-Binomial distribution.

Space Environment Effects: Model for Emission of Solar Protons (ESP): Cumulative and Worst Case Event Fluences

NASA Technical Reports Server (NTRS)

Xapsos, M. A.; Barth, J. L.; Stassinopoulos, E. G.; Burke, E. A.; Gee, G. B.

1999-01-01

The effects that solar proton events have on microelectronics and solar arrays are important considerations for spacecraft in geostationary and polar orbits and for interplanetary missions. Designers of spacecraft and mission planners are required to assess the performance of microelectronic systems under a variety of conditions. A number of useful approaches exist for predicting information about solar proton event fluences and, to a lesser extent, peak fluxes. This includes the cumulative fluence over the course of a mission, the fluence of a worst-case event during a mission, the frequency distribution of event fluences, and the frequency distribution of large peak fluxes. Naval Research Laboratory (NRL) and NASA Goddard Space Flight Center, under the sponsorship of NASA's Space Environments and Effects (SEE) Program, have developed a new model for predicting cumulative solar proton fluences and worst-case solar proton events as functions of mission duration and user confidence level. This model is called the Emission of Solar Protons (ESP) model.

Space Environment Effects: Model for Emission of Solar Protons (ESP)--Cumulative and Worst-Case Event Fluences

NASA Technical Reports Server (NTRS)

Xapsos, M. A.; Barth, J. L.; Stassinopoulos, E. G.; Burke, Edward A.; Gee, G. B.

1999-01-01

The effects that solar proton events have on microelectronics and solar arrays are important considerations for spacecraft in geostationary and polar orbits and for interplanetary missions. Designers of spacecraft and mission planners are required to assess the performance of microelectronic systems under a variety of conditions. A number of useful approaches exist for predicting information about solar proton event fluences and, to a lesser extent, peak fluxes. This includes the cumulative fluence over the course of a mission, the fluence of a worst-case event during a mission, the frequency distribution of event fluences, and the frequency distribution of large peak fluxes. Naval Research Laboratory (NRL) and NASA Goddard Space Flight Center, under the sponsorship of NASA's Space Environments and Effects (SEE) Program, have developed a new model for predicting cumulative solar proton fluences and worst-case solar proton events as functions of mission duration and user confidence level. This model is called the Emission of Solar Protons (ESP) model.

Polar Cap Energy Deposition Events During the 5-6 August 2011 Magnetic Storm

NASA Astrophysics Data System (ADS)

Horvath, Ildiko; Lovell, Brian C.

2018-03-01

We study the 5-6 August 2011 storm for its energy deposition events occurring deep in the polar cap region, where the consequential localized intensifications of earthward directed Poynting flux led to the development of their related localized neutral density increases. For unraveling the underlying physical processes, we investigate the relations among Poynting flux intensifications, flow channels (FCs), and localized neutral density enhancements plus the nature of the underlying reconnection events. Observational results demonstrate Poynting flux increase deep in the polar cap in a FC-2 type FC during magnetopause reconnections and in a FC-4 type FC during lobe reconnections. During the latter stages of these different types of reconnection events, energy/momentum transfer occurred along old-open field lines and commonly led to the development of localized neutral density increases during their respective upwelling events fueled by field-aligned currents and above/within these polar FCs. The prevailing BY domination and the pulsed nature of this storm created favorable conditions for the development of these FC-2 and FC-4 types in the sunlit northern summer hemisphere and caused the observed Poynting flux intensifications deep in the polar cap. The solar wind source of these reconnections taking place along old-open field lines was situated in the high-latitude boundary layer. Thus, the high-latitude boundary layer dynamo provided a vigorous source of energy/momentum transfer during the latter-stage reconnections unfolding along old-open field lines.

Physical and Economic Impacts of Sea-Level Rise and Low Probability Flooding Events on Coastal Communities

PubMed Central

Prime, Thomas; Brown, Jennifer M.; Plater, Andrew J.

2015-01-01

Conventionally flood mapping typically includes only a static water level (e.g. peak of a storm tide) in coastal flood inundation events. Additional factors become increasingly important when increased water-level thresholds are met during the combination of a storm tide and increased mean sea level. This research incorporates factors such as wave overtopping and river flow in a range of flood inundation scenarios of future sea-level projections for a UK case study of Fleetwood, northwest England. With increasing mean sea level it is shown that wave overtopping and river forcing have an important bearing on the cost of coastal flood events. The method presented converts inundation maps into monetary cost. This research demonstrates that under scenarios of joint extreme surge-wave-river events the cost of flooding can be increased by up to a factor of 8 compared with an increase in extent of up to a factor of 3 relative to “surge alone” event. This is due to different areas being exposed to different flood hazards and areas with common hazard where flood waters combine non-linearly. This shows that relying simply on flood extent and volume can under-predict the actual economic impact felt by a coastal community. Additionally, the scenario inundation depths have been presented as “brick course” maps, which represent a new way of interpreting flood maps. This is primarily aimed at stakeholders to increase levels of engagement within the coastal community. PMID:25710497

Physical and economic impacts of sea-level rise and low probability flooding events on coastal communities.

PubMed

Prime, Thomas; Brown, Jennifer M; Plater, Andrew J

2015-01-01

Conventionally flood mapping typically includes only a static water level (e.g. peak of a storm tide) in coastal flood inundation events. Additional factors become increasingly important when increased water-level thresholds are met during the combination of a storm tide and increased mean sea level. This research incorporates factors such as wave overtopping and river flow in a range of flood inundation scenarios of future sea-level projections for a UK case study of Fleetwood, northwest England. With increasing mean sea level it is shown that wave overtopping and river forcing have an important bearing on the cost of coastal flood events. The method presented converts inundation maps into monetary cost. This research demonstrates that under scenarios of joint extreme surge-wave-river events the cost of flooding can be increased by up to a factor of 8 compared with an increase in extent of up to a factor of 3 relative to "surge alone" event. This is due to different areas being exposed to different flood hazards and areas with common hazard where flood waters combine non-linearly. This shows that relying simply on flood extent and volume can under-predict the actual economic impact felt by a coastal community. Additionally, the scenario inundation depths have been presented as "brick course" maps, which represent a new way of interpreting flood maps. This is primarily aimed at stakeholders to increase levels of engagement within the coastal community.

Distributions of observed death tolls govern sensitivity to human fatalities

PubMed Central

Olivola, Christopher Y.; Sagara, Namika

2009-01-01

How we react to humanitarian crises, epidemics, and other tragic events involving the loss of human lives depends largely on the extent to which we are moved by the size of their associated death tolls. Many studies have demonstrated that people generally exhibit a diminishing sensitivity to the number of human fatalities and, equivalently, a preference for risky (vs. sure) alternatives in decisions under risk involving human losses. However, the reason for this tendency remains unknown. Here we show that the distributions of event-related death tolls that people observe govern their evaluations of, and risk preferences concerning, human fatalities. In particular, we show that our diminishing sensitivity to human fatalities follows from the fact that these death tolls are approximately power-law distributed. We further show that, by manipulating the distribution of mortality-related events that people observe, we can alter their risk preferences in decisions involving fatalities. Finally, we show that the tendency to be risk-seeking in mortality-related decisions is lower in countries in which high-mortality events are more frequently observed. Our results support a model of magnitude evaluation based on memory sampling and relative judgment. This model departs from the utility-based approaches typically encountered in psychology and economics in that it does not rely on stable, underlying value representations to explain valuation and choice, or on choice behavior to derive value functions. Instead, preferences concerning human fatalities emerge spontaneously from the distributions of sampled events and the relative nature of the evaluation process. PMID:20018778

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke.

PubMed

Talley Watts, Lora; Zheng, Wei; Garling, R Justin; Frohlich, Victoria C; Lechleiter, James Donald

2015-06-23

In vivo imaging techniques have increased in utilization due to recent advances in imaging dyes and optical technologies, allowing for the ability to image cellular events in an intact animal. Additionally, the ability to induce physiological disease states such as stroke in vivo increases its utility. The technique described herein allows for physiological assessment of cellular responses within the CNS following a stroke and can be adapted for other pathological conditions being studied. The technique presented uses laser excitation of the photosensitive dye Rose Bengal in vivo to induce a focal ischemic event in a single blood vessel. The video protocol demonstrates the preparation of a thin-skulled cranial window over the somatosensory cortex in a mouse for the induction of a Rose Bengal photothrombotic event keeping injury to the underlying dura matter and brain at a minimum. Surgical preparation is initially performed under a dissecting microscope with a custom-made surgical/imaging platform, which is then transferred to a confocal microscope equipped with an inverted objective adaptor. Representative images acquired utilizing this protocol are presented as well as time-lapse sequences of stroke induction. This technique is powerful in that the same area can be imaged repeatedly on subsequent days facilitating longitudinal in vivo studies of pathological processes following stroke.

United States Air Force Statistical Digest, Fiscal Year 1965, Twentieth Edition

DTIC Science & Technology

1965-09-30

prOVided by the USAF under Military Assistance Program . MAP EMPLOYEES - Category of civilian personnel engaged in activities reqUired in carrying out the...92 - USAF CIVIUAN EMPLOYEES IN SALARIED AND WAGE BOARD GROUPS EMPLOYED UNDER MILITARY ASSISTANCE PROGRAM (MAP), WORLO-WIDE, AT END OF QUARTER - FY...statistical material for tary Assistance Program (MAP), and re- the digest. AFCHO will furnish a chronology lated studies and historical events. of

Taking transgenic rice drought screening to the field.

PubMed

Gaudin, Amélie C M; Henry, Amelia; Sparks, Adam H; Slamet-Loedin, Inez H

2013-01-01

Numerous transgenes have been reported to increase rice drought resistance, mostly in small-scale experiments under vegetative-stage drought stress, but few studies have included grain yield or field evaluations. Different definitions of drought resistance are currently in use for field-based and laboratory evaluations of transgenics, the former emphasizing plant responses that may not be linked to yield under drought. Although those fundamental studies use efficient protocols to uncover and validate gene functions, screening conditions differ greatly from field drought environments where the onset of drought stress symptoms is slow (2-3 weeks). Simplified screening methods, including severely stressed survival studies, are therefore not likely to identify transgenic events with better yield performance under drought in the target environment. As biosafety regulations are becoming established to allow field trials in some rice-producing countries, there is a need to develop relevant screening procedures that scale from preliminary event selection to greenhouse and field trials. Multilocation testing in a range of drought environments may reveal that different transgenes are necessary for different types of drought-prone field conditions. We describe here a pipeline to improve the selection efficiency and reproducibility of results across drought treatments and test the potential of transgenic rice for the development of drought-resistant material for agricultural purposes.

75 FR 11589 - Order Extending Temporary Exemptions Under the Securities Exchange Act of 1934 in Connection with...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... make payments under a CDS contract is triggered by a default or other credit event as to such entity or... CDS clearing by ICE Trust. We recognize, however, that there could be legal uncertainty in the event..., and the access to clearing services by independent CDS exchanges or CDS trading platforms.\\15\\ \\15...

5 CFR 847.604 - Methodology for determining deficiency.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Methodology for determining deficiency. (a) When an event listed in the left column of the table in Appendix A... transfer to the Fund under subpart E of this part including earnings under § 847.507. (2) OPM will add the... (a)(2) of this section is greater than zero, the deficiency is equal to that amount. (c) If no event...

5 CFR 847.604 - Methodology for determining deficiency.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Methodology for determining deficiency. (a) When an event listed in the left column of the table in Appendix A... transfer to the Fund under subpart E of this part including earnings under § 847.507. (2) OPM will add the... (a)(2) of this section is greater than zero, the deficiency is equal to that amount. (c) If no event...

5 CFR 847.604 - Methodology for determining deficiency.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Methodology for determining deficiency. (a) When an event listed in the left column of the table in Appendix A... transfer to the Fund under subpart E of this part including earnings under § 847.507. (2) OPM will add the... (a)(2) of this section is greater than zero, the deficiency is equal to that amount. (c) If no event...

A novel approach for analyzing data on recurrent events with duration to estimate the combined cumulative rate of both variables over time.

PubMed

Bhattacharya, Sudipta

2018-06-01

Recurrent adverse events, once occur often continue for some duration of time in clinical trials; and the number of events along with their durations is clinically considered as a measure of severity of a disease under study. While there are methods available for analyzing recurrent events or durations or for analyzing both side by side, no effort has been made so far to combine them and present as a single measure. However, this single-valued combined measure may help clinicians assess the wholesome effect of recurrence of incident comprising events and durations. Non-parametric approach is adapted here to develop an estimator for estimating the combined rate of both, the recurrence of events as well as the event-continuation, that is the duration per event. The proposed estimator produces a single numerical value, the interpretation and meaningfulness of which are discussed through the analysis of a real-life clinical dataset. The algebraic expression of variance is derived, asymptotic normality of the estimator is noted, and demonstration is provided on how the estimator can be used in the setup of testing of statistical hypothesis. Further possible development of the estimator is also noted, to adjust for the dependence of event occurrences on the history of the process generating recurrent events through covariates and for the case of dependent censoring.

Effects of climate change adaptation scenarios on perceived spatio-temporal characteristics of drought events

NASA Astrophysics Data System (ADS)

Vidal, J.-P.; Martin, E.; Kitova, N.; Najac, J.; Soubeyroux, J.-M.

2012-04-01

Drought events develop in both space and time and they are therefore best described through summary joint spatio-temporal characteristics, like mean duration, mean affected area and total magnitude. This study addresses the issue of future projections of such characteristics of drought events over France through three main research questions: (1) Are downscaled climate projections able to reproduce spatio-temporal characteristics of meteorological and agricultural droughts in France over a present-day period? (2) How such characteristics will evolve over the 21st century under different emissions scenarios? (3) How would perceived drought characteristics evolve under theoretical adaptation scenarios? These questions are addressed using the Isba land surface model, downscaled climate projections from the ARPEGE General Circulation Model under three emissions scenarios, as well as results from a previously performed 50-year multilevel and multiscale drought reanalysis over France (Vidal et al., 2010). Spatio-temporal characteristics of meteorological and agricultural drought events are computed using the Standardized Precipitation Index (SPI) and the Standardized Soil Wetness Index (SSWI), respectively, and for time scales of 3 and 12 months. Results first show that the distributions of joint spatio-temporal characteristics of observed events are well reproduced by the downscaled hydroclimate projections over a present-day period. All spatio-temporal characteristics of drought events are then found to dramatically increase over the 21st century under all considered emissions scenarios, with stronger changes for agricultural droughts. Two theoretical adaptation scenarios are eventually built based on hypotheses of adaptation to evolving climate and hydrological normals. The two scenarios differ by the way the transient adaptation is performed for a given date in the future, with reference to the normals over either the previous 30-year window ("retrospective" adaptation) or over a 30-year period centred around the date considered ("prospective" adaptation). These adaptation scenarios are translated into local-scale transient drought thresholds, as opposed to a non-adaptation scenario where the drought threshold remains constant. The perceived spatio-temporal characteristics derived from the theoretical adaptation scenarios show much reduced changes, but they call for more realistic scenarios at both the catchment and national scale in order to accurately assess the combined effect of local-scale adaptation and global-scale mitigation. This study thus proposes a proof of concept for using standardized drought indices for (1) assessing projections of spatio-temporal drought characteristics and (2) building theoretical adaptation scenarios and associated perceived changes in hydrological impact studies (Vidal et al., submitted). Vidal J.-P., Martin E., Franchistéguy L., Habets F., Soubeyroux J.-M., Blanchard M. & Baillon M. (2010) Multilevel and multiscale drought reanalysis over France with the Safran-Isba-Modcou hydrometeorological suite. Hydrology and Earth System Sciences, 14, 459-478.doi: 10.5194/hess-14-459-2010 Vidal J.-P., Martin E., Kitova N., Najac J. & Soubeyroux, J. M. (submitted) Evolution of spatio-temporal drought characteristics: validation, projections and effect of adaptation scenarios. Submitted to Hydrology and earth System Sciences

Event structure and cognitive control.

PubMed

Reimer, Jason F; Radvansky, Gabriel A; Lorsbach, Thomas C; Armendarez, Joseph J

2015-09-01

Recently, a great deal of research has demonstrated that although everyday experience is continuous in nature, it is parsed into separate events. The aim of the present study was to examine whether event structure can influence the effectiveness of cognitive control. Across 5 experiments we varied the structure of events within the AX-CPT by shifting the spatial location of cues and probes on a computer screen. When location shifts were present, a pattern of AX-CPT performance consistent with enhanced cognitive control was found. To test whether the location shift effects were caused by the presence of event boundaries per se, other aspects of the AX-CPT were manipulated, such as the color of cues and probes and the inclusion of a distractor task during the cue-probe delay. Changes in cognitive control were not found under these conditions, suggesting that the location shift effects were specifically related to the formation of separate event models. Together, these results can be accounted for by the Event Horizon Model and a representation-based theory of cognitive control, and suggest that cognitive control can be influenced by the surrounding environmental structure. (c) 2015 APA, all rights reserved).

Characteristics of pulsed runoff-erosion events under typical rainstorms in a small watershed on the Loess Plateau of China.

PubMed

Wu, Lei; Jiang, Jun; Li, Gou-Xia; Ma, Xiao-Yi

2018-02-27

The pulsed events of rainstorm erosion on the Loess Plateau are well-known, but little information is available concerning the characteristics of superficial soil erosion processes caused by heavy rainstorms at the watershed scale. This study statistically evaluated characteristics of pulsed runoff-erosion events based on 17 observed rainstorms from 1997-2010 in a small loess watershed on the Loess Plateau of China. Results show that: 1) Rainfall is the fundamental driving force of soil erosion on hillslopes, but the correlations of rainfall-runoff and rainfall-sediment in different rainstorms are often scattered due to infiltration-excess runoff and soil conservation measures. 2) Relationships between runoff and sediment for each rainstorm event can be regressed by linear, power, logarithmic and exponential functions. Cluster Analysis is helpful in classifying runoff-erosion events and formulating soil conservation strategies for rainstorm erosion. 3) Response characteristics of sediment yield are different in different levels of pulsed runoff-erosion events. Affected by rainfall intensity and duration, large changes may occur in the interactions between flow and sediment for different flood events. Results provide new insights into runoff-erosion processes and will assist soil conservation planning in the loess hilly region.

The reminiscence bump in autobiographical memory and for public events: A comparison across different cueing methods.

PubMed

Koppel, Jonathan; Berntsen, Dorthe

2016-01-01

The reminiscence bump has been found for both autobiographical memories and memories of public events. However, there have been few comparisons of the bump across each type of event. In the current study, therefore, we compared the bump for autobiographical memories versus the bump for memories of public events. We did so between-subjects, through two cueing methods administered within-subjects, the cue word method and the important memories method. For word-cued memories, we found a similar bump from ages 5 to 19 for both types of memories. However, the bump was more pronounced for autobiographical memories. For most important memories, we found a bump from ages 20 to 29 in autobiographical memory, but little discernible age pattern for public events. Rather, specific public events (e.g., the Fall of the Berlin Wall) dominated recall, producing a chronological distribution characterised by spikes in citations according to the years these events occurred. Follow-up analyses suggested that the bump in most important autobiographical memories was a function of the cultural life script. Our findings did not yield support for any of the dominant existing accounts of the bump as underlying the bump in word-cued memories.

Extreme High-Temperature Events Over East Asia in 1.5°C and 2°C Warmer Futures: Analysis of NCAR CESM Low-Warming Experiments

NASA Astrophysics Data System (ADS)

Li, Donghuan; Zhou, Tianjun; Zou, Liwei; Zhang, Wenxia; Zhang, Lixia

2018-02-01

Extreme high-temperature events have large socioeconomic and human health impacts. East Asia (EA) is a populous region, and it is crucial to assess the changes in extreme high-temperature events in this region under different climate change scenarios. The Community Earth System Model low-warming experiment data were applied to investigate the changes in the mean and extreme high temperatures in EA under 1.5°C and 2°C warming conditions above preindustrial levels. The results show that the magnitude of warming in EA is approximately 0.2°C higher than the global mean. Most populous subregions, including eastern China, the Korean Peninsula, and Japan, will see more intense, more frequent, and longer-lasting extreme temperature events under 1.5°C and 2°C warming. The 0.5°C lower warming will help avoid 35%-46% of the increases in extreme high-temperature events in terms of intensity, frequency, and duration in EA with maximal avoidance values (37%-49%) occurring in Mongolia. Thus, it is beneficial for EA to limit the warming target to 1.5°C rather than 2°C.

PS1-41: Just Add Data: Implementing an Event-Based Data Model for Clinical Trial Tracking

PubMed Central

Fuller, Sharon; Carrell, David; Pardee, Roy

2012-01-01

Background/Aims Clinical research trials often have similar fundamental tracking needs, despite being quite variable in their specific logic and activities. A model tracking database that can be quickly adapted by a variety of studies has the potential to achieve significant efficiencies in database development and maintenance. Methods Over the course of several different clinical trials, we have developed a database model that is highly adaptable to a variety of projects. Rather than hard-coding each specific event that might occur in a trial, along with its logical consequences, this model considers each event and its parameters to be a data record in its own right. Each event may have related variables (metadata) describing its prerequisites, subsequent events due, associated mailings, or events that it overrides. The metadata for each event is stored in the same record with the event name. When changes are made to the study protocol, no structural changes to the database are needed. One has only to add or edit events and their metadata. Changes in the event metadata automatically determine any related logic changes. In addition to streamlining application code, this model simplifies communication between the programmer and other team members. Database requirements can be phrased as changes to the underlying data, rather than to the application code. The project team can review a single report of events and metadata and easily see where changes might be needed. In addition to benefitting from streamlined code, the front end database application can also implement useful standard features such as automated mail merges and to do lists. Results The event-based data model has proven itself to be robust, adaptable and user-friendly in a variety of study contexts. We have chosen to implement it as a SQL Server back end and distributed Access front end. Interested readers may request a copy of the Access front end and scripts for creating the back end database. Discussion An event-based database with a consistent, robust set of features has the potential to significantly reduce development time and maintenance expense for clinical trial tracking databases.

Forecasting Significant Societal Events Using The Embers Streaming Predictive Analytics System

PubMed Central

Katz, Graham; Summers, Kristen; Ackermann, Chris; Zavorin, Ilya; Lim, Zunsik; Muthiah, Sathappan; Butler, Patrick; Self, Nathan; Zhao, Liang; Lu, Chang-Tien; Khandpur, Rupinder Paul; Fayed, Youssef; Ramakrishnan, Naren

2014-01-01

Abstract Developed under the Intelligence Advanced Research Project Activity Open Source Indicators program, Early Model Based Event Recognition using Surrogates (EMBERS) is a large-scale big data analytics system for forecasting significant societal events, such as civil unrest events on the basis of continuous, automated analysis of large volumes of publicly available data. It has been operational since November 2012 and delivers approximately 50 predictions each day for countries of Latin America. EMBERS is built on a streaming, scalable, loosely coupled, shared-nothing architecture using ZeroMQ as its messaging backbone and JSON as its wire data format. It is deployed on Amazon Web Services using an entirely automated deployment process. We describe the architecture of the system, some of the design tradeoffs encountered during development, and specifics of the machine learning models underlying EMBERS. We also present a detailed prospective evaluation of EMBERS in forecasting significant societal events in the past 2 years. PMID:25553271

Probing collective effects in hadronisation with the extremes of the underlying event

NASA Astrophysics Data System (ADS)

Martin, T.; Skands, P.; Farrington, S.

2016-05-01

We define a new set of observables to probe the structure of the underlying event in hadron collisions. We use the conventional definition of the "transverse region" in jet events and, for a fixed window in jet p_perp , propose to measure several discriminating quantities as a function of the level of activity in the transverse region. The measurement of these observables in LHC data would reveal whether, e.g., the properties of "low-UE" events are compatible with equivalent measurements in e^+e^- collisions (jet universality), and whether the scaling behaviour towards "high-UE" events exhibits properties of non-trivial soft-QCD dynamics, such as colour reconnections or other collective phenomena. We illustrate at √{s} = 13 {TeV} that significant discriminatory power is obtained in comparisons between MC models with varying treatments of collective effects, including Pythia 8, epos, and Dipsy.

Forecasting Significant Societal Events Using The Embers Streaming Predictive Analytics System.

PubMed

Doyle, Andy; Katz, Graham; Summers, Kristen; Ackermann, Chris; Zavorin, Ilya; Lim, Zunsik; Muthiah, Sathappan; Butler, Patrick; Self, Nathan; Zhao, Liang; Lu, Chang-Tien; Khandpur, Rupinder Paul; Fayed, Youssef; Ramakrishnan, Naren

2014-12-01

Developed under the Intelligence Advanced Research Project Activity Open Source Indicators program, Early Model Based Event Recognition using Surrogates (EMBERS) is a large-scale big data analytics system for forecasting significant societal events, such as civil unrest events on the basis of continuous, automated analysis of large volumes of publicly available data. It has been operational since November 2012 and delivers approximately 50 predictions each day for countries of Latin America. EMBERS is built on a streaming, scalable, loosely coupled, shared-nothing architecture using ZeroMQ as its messaging backbone and JSON as its wire data format. It is deployed on Amazon Web Services using an entirely automated deployment process. We describe the architecture of the system, some of the design tradeoffs encountered during development, and specifics of the machine learning models underlying EMBERS. We also present a detailed prospective evaluation of EMBERS in forecasting significant societal events in the past 2 years.

Evaluation of estimation methods and power of tests of discrete covariates in repeated time-to-event parametric models: application to Gaucher patients treated by imiglucerase.

PubMed

Vigan, Marie; Stirnemann, Jérôme; Mentré, France

2014-05-01

Analysis of repeated time-to-event data is increasingly performed in pharmacometrics using parametric frailty models. The aims of this simulation study were (1) to assess estimation performance of Stochastic Approximation Expectation Maximization (SAEM) algorithm in MONOLIX, Adaptive Gaussian Quadrature (AGQ), and Laplace algorithm in PROC NLMIXED of SAS and (2) to evaluate properties of test of a dichotomous covariate on occurrence of events. The simulation setting is inspired from an analysis of occurrence of bone events after the initiation of treatment by imiglucerase in patients with Gaucher Disease (GD). We simulated repeated events with an exponential model and various dropout rates: no, low, or high. Several values of baseline hazard model, variability, number of subject, and effect of covariate were studied. For each scenario, 100 datasets were simulated for estimation performance and 500 for test performance. We evaluated estimation performance through relative bias and relative root mean square error (RRMSE). We studied properties of Wald and likelihood ratio test (LRT). We used these methods to analyze occurrence of bone events in patients with GD after starting an enzyme replacement therapy. SAEM with three chains and AGQ algorithms provided good estimates of parameters much better than SAEM with one chain and Laplace which often provided poor estimates. Despite a small number of repeated events, SAEM with three chains and AGQ gave small biases and RRMSE. Type I errors were closed to 5%, and power varied as expected for SAEM with three chains and AGQ. Probability of having at least one event under treatment was 19.1%.

Polygraphic respiratory events during sleep with noninvasive ventilation in children: description, prevalence, and clinical consequences.

PubMed

Caldarelli, Valeria; Borel, Jean Christian; Khirani, Sonia; Ramirez, Adriana; Cutrera, Renato; Pépin, Jean-Louis; Fauroux, Brigitte

2013-04-01

The optimal monitoring during sleep with noninvasive positive pressure ventilation (NPPV) has not been validated in children. The aim of the study was to describe on polygraphic (PG) recordings the respiratory events and associated autonomic arousals (AA) and/or 3 % desaturations (DS3%) during nocturnal NPPV. This was a prospective descriptive study performed in the pulmonology unit of a pediatric university hospital. Consecutive patients admitted for routine follow-up of long-term NPPV were enrolled. Nocturnal PG during sleep with NPPV was performed. A second PG was performed after adjustment of the ventilatory settings when a respiratory event occurred more than 50 times/h. The PG tracings of 39 patients (age range 1-18 years) were analyzed. Underlying diagnoses included neuromuscular disease (n = 13), obstructive sleep apnea (n = 15), and lung disease (n = 11). Unintentional leaks, patient-ventilator asynchronies, decrease in ventilatory drive, upper airway obstruction with or without reduction of ventilatory drive, and mixed events were observed in 27, 33, 10, 11, 12, and 3 % of the patients, respectively. A predominant respiratory event was observed in all patients. The mean duration spent with respiratory events was 32 ± 30 % (range 3-96 %) of total recording time. Unintentional leaks were the most frequently associated with AA, whereas patient-ventilator asynchronies were rarely associated with AA or DS3%. In eight re-evaluated patients, a decrease in the main event was observed (p = 0.005). Respiratory events during sleep with NPPV are common in children treated with long-term NPPV. Consequences of respiratory events vary according to the type of event with unintentional leaks being associated preferentially with AA.

Precision searches in dijets at the HL-LHC and HE-LHC

NASA Astrophysics Data System (ADS)

Chekanov, S. V.; Childers, J. T.; Proudfoot, J.; Wang, R.; Frizzell, D.

2018-05-01

This paper explores the physics reach of the High-Luminosity Large Hadron Collider (HL-LHC) for searches of new particles decaying to two jets. We discuss inclusive searches in dijets and b-jets, as well as searches in semi-inclusive events by requiring an additional lepton that increases sensitivity to different aspects of the underlying processes. We discuss the expected exclusion limits for generic models predicting new massive particles that result in resonant structures in the dijet mass. Prospects of the Higher-Energy LHC (HE-LHC) collider are also discussed. The study is based on the Pythia8 Monte Carlo generator using representative event statistics for the HL-LHC and HE-LHC running conditions. The event samples were created using supercomputers at NERSC.

A methodology to select a wire insulation for use in habitable spacecraft.

PubMed

Paulos, T; Apostolakis, G

1998-08-01

This paper investigates electrical overheating events aboard a habitable spacecraft. The wire insulation involved in these failures plays a major role in the entire event scenario from threat development to detection and damage assessment. Ideally, if models of wire overheating events in microgravity existed, the various wire insulations under consideration could be quantitatively compared. However, these models do not exist. In this paper, a methodology is developed that can be used to select a wire insulation that is best suited for use in a habitable spacecraft. The results of this study show that, based upon the Analytic Hierarchy Process and simplifying assumptions, the criteria selected, and data used in the analysis, Tefzel is better than Teflon for use in a habitable spacecraft.

Swimming against the tide: resilience of a riverine turtle to recurrent extreme environmental events

PubMed Central

Jergenson, Abigail M.; Miller, David A. W.; Neuman-Lee, Lorin A.; Warner, Daniel A.; Janzen, Fredric J.

2014-01-01

Extreme environmental events (EEEs) are likely to exert deleterious effects on populations. From 1996 to 2012 we studied the nesting dynamics of a riverine population of painted turtles (Chrysemys picta) that experienced seven years with significantly definable spring floods. We used capture–mark–recapture methods to estimate the relationships between more than 5 m and more than 6 m flood events and population parameters. Contrary to expectations, flooding was not associated with annual differences in survival, recruitment or annual population growth rates of the adult female segment of the population. These findings suggest that female C. picta exhibit resiliency to key EEE, which are expected to increase in frequency under climate change. PMID:24621555

Multicenter, open-label study of recombinant human DNase in cystic fibrosis patients with moderate lung disease. DNase International Study Group.

PubMed

Harms, H K; Matouk, E; Tournier, G; von der Hardt, H; Weller, P H; Romano, L; Heijerman, H G; FitzGerald, M X; Richard, D; Strandvik, B; Kolbe, J; Kraemer, R; Michalsen, H

1998-09-01

Cystic fibrosis is characterized by the accumulation of thick viscous purulent secretions. Recombinant human deoxyribonuclease I (rhDNase) breaks down extracellular DNA, which contributes to the increased viscosity of sputum. A multinational, open-label study was conducted in 974 cystic fibrosis patients with moderate lung disease [forced vital capacity (FVC) 40-70% of predicted values] to examine the safety and efficacy of aerosolized rhDNase, 2.5 mg, once daily over a period of at least 12 weeks. Patients were assessed under conditions reflecting routine clinical practice. During rhDNase therapy, at least one respiratory tract infection (RTI) requiring intravenous antibiotics was experienced by 29.5% of patients. Forced expiratory volume in 1 second (FEV1) and FVC were significantly improved from baseline by a mean of 10.5% and 7.2%, respectively. Voice alteration and pharyngitis were the most frequent rhDNase-related adverse events, but only 2% of all patients discontinued treatment due to adverse events. The results obtained were similar to a subanalysis of data from the first 3 months of a placebo-controlled U.S. study. The patients in the present study had a similar frequency of RTIs and improvement in pulmonary function, and reported fewer rhDNase-related and cystic fibrosis-related adverse events than patients in the U.S. study. We conclude that administration of rhDNase is safe, well tolerated, and effective under conditions reflecting routine clinical practice in patients with cystic fibrosis and moderate lung disease.

Crude incidence in two-phase designs in the presence of competing risks.

PubMed

Rebora, Paola; Antolini, Laura; Glidden, David V; Valsecchi, Maria Grazia

2016-01-11

In many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies. Common examples include the nested case-control and the case-cohort designs. For two-phase studies, appropriate weighted survival estimates have been derived; however, no estimator of cumulative incidence accounting for competing events has been proposed. This is relevant in the presence of multiple types of events, where estimation of event type specific quantities are needed for evaluating outcome. We develop a non parametric estimator of the cumulative incidence function of events accounting for possible competing events. It handles a general sampling design by weights derived from the sampling probabilities. The variance is derived from the influence function of the subdistribution hazard. The proposed method shows good performance in simulations. It is applied to estimate the crude incidence of relapse in childhood acute lymphoblastic leukemia in groups defined by a genotype not available for everyone in a cohort of nearly 2000 patients, where death due to toxicity acted as a competing event. In a second example the aim was to estimate engagement in care of a cohort of HIV patients in resource limited setting, where for some patients the outcome itself was missing due to lost to follow-up. A sampling based approach was used to identify outcome in a subsample of lost patients and to obtain a valid estimate of connection to care. A valid estimator for cumulative incidence of events accounting for competing risks under a general sampling design from an infinite target population is derived.

Spatial and Temporal Energy Characterization of Precipitating Electrons for the January 10th, 1997 Magnetic Cloud Event

NASA Technical Reports Server (NTRS)

Spann, J. F., Jr.; Germany, G. A.; Brittnacher, M. J.; Parks, G. K.; Elsen, R.

1997-01-01

The January 10-11, 1997 magnetic cloud event provided a rare opportunity to study auroral energy deposition under varying but intense IMF conditions. The Wind spacecraft located about 100 RE upstream monitored the IMF and plasma parameters during the passing of the cloud. The Polar Ultraviolet Imager (UVI) observed the aurora[ precipitation during the first encounter of the cloud with Earth's magnetosphere and during several subsequent substorm events. The UVI has the unique capability of measuring the energy flux and characteristic energy of the precipitating electrons through the use of narrow band filters that distinguish short and long wavelength molecular nitrogen emissions. The spatial and temporal characteristics of the precipitating electron energy will be discussed beginning with the inception of the event at the Earth early January 1 Oth and continuing through the subsidence of auroral activity on January 11th.

On the significance of future trends in flood frequencies

NASA Astrophysics Data System (ADS)

Bernhardt, M.; Schulz, K.; Wieder, O.

2015-12-01

Floods are a significant threat for alpine headwater catchments and for the forelands. The formation of significant flood events is thereby often coupled on processes occurring in the alpine zone. Rain on snow events are just one example. The prediction of flood risks or trends of flood risks is of major interest to people under direct threat, policy and decision makers as well as for insurance companies. A lot of research was and is currently done in view of detecting future trends in flood extremes or return periods. From a pure physically based point of view, there is strong evidence that those trends exist. But, the central point question is if trends in flood events or other extreme events could be detected from a statistical point of view and on the basis of the available data. This study will investigate this question on the basis of different target parameters and by using long term measurements.

Competency Based Competitive Events. Integrating DECA into the DE Instructional Program.

ERIC Educational Resources Information Center

Cosgrove, Glenna; Moore, Harold W.

Designed to be integrated into a competency-based distributive education program, these competitive DECA (Distributive Education Clubs of America) events were developed, utilized, and evaluated by distributive education and cooperative education coordinators in Arkansas. These events are organized under the following occupational categories: food…

29 CFR 4043.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the Code. Subpart A contains definitions and general rules. Subpart B contains rules for post-event... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND... prescribes the requirements for notifying the PBGC of a reportable event under section 4043 of ERISA or of a...

29 CFR 4043.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the Code. Subpart A contains definitions and general rules. Subpart B contains rules for post-event... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND... prescribes the requirements for notifying the PBGC of a reportable event under section 4043 of ERISA or of a...

29 CFR 4043.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the Code. Subpart A contains definitions and general rules. Subpart B contains rules for post-event... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND... prescribes the requirements for notifying the PBGC of a reportable event under section 4043 of ERISA or of a...

29 CFR 4043.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the Code. Subpart A contains definitions and general rules. Subpart B contains rules for post-event... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND... prescribes the requirements for notifying the PBGC of a reportable event under section 4043 of ERISA or of a...

29 CFR 4043.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Code. Subpart A contains definitions and general rules. Subpart B contains rules for post-event... Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION PLAN TERMINATIONS REPORTABLE EVENTS AND... prescribes the requirements for notifying the PBGC of a reportable event under section 4043 of ERISA or of a...

Flood risk analysis for flood control and sediment transportation in sandy regions: A case study in the Loess Plateau, China

NASA Astrophysics Data System (ADS)

Guo, Aijun; Chang, Jianxia; Wang, Yimin; Huang, Qiang; Zhou, Shuai

2018-05-01

Traditional flood risk analysis focuses on the probability of flood events exceeding the design flood of downstream hydraulic structures while neglecting the influence of sedimentation in river channels on regional flood control systems. This work advances traditional flood risk analysis by proposing a univariate and copula-based bivariate hydrological risk framework which incorporates both flood control and sediment transport. In developing the framework, the conditional probabilities of different flood events under various extreme precipitation scenarios are estimated by exploiting the copula-based model. Moreover, a Monte Carlo-based algorithm is designed to quantify the sampling uncertainty associated with univariate and bivariate hydrological risk analyses. Two catchments located on the Loess plateau are selected as study regions: the upper catchments of the Xianyang and Huaxian stations (denoted as UCX and UCH, respectively). The univariate and bivariate return periods, risk and reliability in the context of uncertainty for the purposes of flood control and sediment transport are assessed for the study regions. The results indicate that sedimentation triggers higher risks of damaging the safety of local flood control systems compared with the event that AMF exceeds the design flood of downstream hydraulic structures in the UCX and UCH. Moreover, there is considerable sampling uncertainty affecting the univariate and bivariate hydrologic risk evaluation, which greatly challenges measures of future flood mitigation. In addition, results also confirm that the developed framework can estimate conditional probabilities associated with different flood events under various extreme precipitation scenarios aiming for flood control and sediment transport. The proposed hydrological risk framework offers a promising technical reference for flood risk analysis in sandy regions worldwide.

Cost-effectiveness of dabigatran compared with warfarin for stroke prevention in patients with atrial fibrillation--a real patient data analysis in a Hong Kong teaching hospital.

PubMed

Chang, Andy M; Ho, Jason C S; Yan, Bryan P; Yu, Cheuk Man; Lam, Yat Yin; Lee, Vivian W Y

2013-05-01

To compare the management cost and cost-effectiveness of dabigatran with warfarin in patients with nonvalvular atrial fibrillation (AF) from the hospital's and patients' perspectives. Dabigatran is more cost-effective than warfarin for stroke prevention of AF in Hong Kong. The analysis was performed in conjunction with a drug utilization evaluation of dabigatran study in a teaching hospital in Hong Kong. The study recruited 244 patients who received either dabigatran or warfarin for stroke prevention of AF. A cost-effectiveness analysis was performed and was expressed as an incremental cost-effectiveness ratio (ICER) in averting a cardiac event or a bleeding event. A sensitivity analysis was used on all relevant variables to test the robustness. From the hospital's perspective, the dabigatran group had a lower total cost of management than that of the warfarin group (median: US$421 vs US$1306, P < 0.001) (US$1 = HK$7.75) and was dominant over warfarin. From the patients' perspective, the total cost of management in the dabigatran group was higher than that in warfarin group (median: US$1751 vs US$70, P < 0.001), and the ICER in preventing a cardiac or bleeding event of dabigatran vs warfarin was estimated at US$68,333 and US$20,500, respectively. If dabigatran was subsidized by the hospital, a higher cost would be incurred by the hospital (median: US$1679 vs US$1306, ICER (cardiac and bleeding events): US$15,163 and US$4549, respectively). The study favored dabigatran for stroke prophylaxis in patients with nonvalvular AF in Hong Kong under the current hospital's perspective and provided a reference for further comparisons under patient and subsidization perspectives. © 2013 Wiley Periodicals, Inc.

Amplitude modulation of steady-state visual evoked potentials by event-related potentials in a working memory task

PubMed Central

Yao, Dezhong; Tang, Yu; Huang, Yilan; Su, Sheng

2009-01-01

Previous studies have shown that the amplitude and phase of the steady-state visual-evoked potential (SSVEP) can be influenced by a cognitive task, yet the mechanism of this influence has not been understood. As the event-related potential (ERP) is the direct neural electric response to a cognitive task, studying the relationship between the SSVEP and ERP would be meaningful in understanding this underlying mechanism. In this work, the traditional average method was applied to extract the ERP directly, following the stimulus of a working memory task, while a technique named steady-state probe topography was utilized to estimate the SSVEP under the simultaneous stimulus of an 8.3-Hz flicker and a working memory task; a comparison between the ERP and SSVEP was completed. The results show that the ERP can modulate the SSVEP amplitude, and for regions where both SSVEP and ERP are strong, the modulation depth is large. PMID:19960240

Total electron content responses to HILDCAAs and geomagnetic storms over South America

NASA Astrophysics Data System (ADS)

Mara de Siqueira Negreti, Patricia; Rodrigues de Paula, Eurico; Nicoli Candido, Claudia Maria

2017-12-01

Total electron content (TEC) is extensively used to monitor the ionospheric behavior under geomagnetically quiet and disturbed conditions. This subject is of greatest importance for space weather applications. Under disturbed conditions the two main sources of electric fields, which are responsible for changes in the plasma drifts and for current perturbations, are the short-lived prompt penetration electric fields (PPEFs) and the longer-lasting ionospheric disturbance dynamo (DD) electric fields. Both mechanisms modulate the TEC around the globe and the equatorial ionization anomaly (EIA) at low latitudes. In this work we computed vertical absolute TEC over the low latitude of South America. The analysis was performed considering HILDCAA (high-intensity, long-duration, continuous auroral electrojet (AE) activity) events and geomagnetic storms. The characteristics of storm-time TEC and HILDCAA-associated TEC will be presented and discussed. For both case studies presented in this work (March and August 2013) the HILDCAA event follows a geomagnetic storm, and then a global scenario of geomagnetic disturbances will be discussed. Solar wind parameters, geomagnetic indices, O / N2 ratios retrieved by GUVI instrument onboard the TIMED satellite and TEC observations will be analyzed and discussed. Data from the RBMC/IBGE (Brazil) and IGS GNSS networks were used to calculate TEC over South America. We show that a HILDCAA event may generate larger TEC differences compared to the TEC observed during the main phase of the precedent geomagnetic storm; thus, a HILDCAA event may be more effective for ionospheric response in comparison to moderate geomagnetic storms, considering the seasonal conditions. During the August HILDCAA event, TEC enhancements from ˜ 25 to 80 % (compared to quiet time) were observed. These enhancements are much higher than the quiet-time variability observed in the ionosphere. We show that ionosphere is quite sensitive to solar wind forcing and considering the events studied here, this was the most important source of ionospheric responses. Furthermore, the most important source of TEC changes were the long-lasting PPEFs observed on August 2013, during the HILDCAA event. The importance of this study relies on the peculiarity of the region analyzed characterized by high declination angle and ionospheric gradients which are responsible for creating a complex response during disturbed periods.

A study of various methods for calculating locations of lightning events

NASA Technical Reports Server (NTRS)

Cannon, John R.

1995-01-01

This article reports on the results of numerical experiments on finding the location of lightning events using different numerical methods. The methods include linear least squares, nonlinear least squares, statistical estimations, cluster analysis and angular filters and combinations of such techniques. The experiments involved investigations of methods for excluding fake solutions which are solutions that appear to be reasonable but are in fact several kilometers distant from the actual location. Some of the conclusions derived from the study are that bad data produces fakes, that no fool-proof method of excluding fakes was found, that a short base-line interferometer under development at Kennedy Space Center to measure the direction cosines of an event shows promise as a filter for excluding fakes. The experiments generated a number of open questions, some of which are discussed at the end of the report.

On the micromechanics of slip events in sheared, fluid-saturated fault gouge

NASA Astrophysics Data System (ADS)

Dorostkar, Omid; Guyer, Robert A.; Johnson, Paul A.; Marone, Chris; Carmeliet, Jan

2017-06-01

We used a three-dimensional discrete element method coupled with computational fluid dynamics to study the poromechanical properties of dry and fluid-saturated granular fault gouge. The granular layer was sheared under dry conditions to establish a steady state condition of stick-slip dynamic failure, and then fluid was introduced to study its effect on subsequent failure events. The fluid-saturated case showed increased stick-slip recurrence time and larger slip events compared to the dry case. Particle motion induces fluid flow with local pressure variation, which in turn leads to high particle kinetic energy during slip due to increased drag forces from fluid on particles. The presence of fluid during the stick phase of loading promotes a more stable configuration evidenced by higher particle coordination number. Our coupled fluid-particle simulations provide grain-scale information that improves understanding of slip instabilities and illuminates details of phenomenological, macroscale observations.

Someone to watch over me: exposure to war events and trust in the armed forces in Israel as factors in war-related stress.

PubMed

Zysberg, Leehu; Kimhi, Shaul; Eshel, Yochanan

2013-01-01

This study examined the role of trust in the national armed and security forces in Israel as a potential protective factor in post-war stress symptoms, alongside other known correlates such as exposure to war events, sense of danger, and demographics. A cluster sample of 870 residents of the town of Kiryat-Shemona in Israel participated in this correlational study. The town was under heavy bombing during the second Lebanon war, and data collection took place about a year after the end of the war. Our results suggest that while sense of danger and exposure to war events are the strongest correlates of stress related symptoms, trust in the armed forces was negatively correlated with stress, even after controlling for demographics; therefore supporting our hypothesis. Theoretical, methodological and practical implications are discussed in light of our findings.

The influence of the mining operation on the mine seismicity of Vorkuta coal deposit

NASA Astrophysics Data System (ADS)

Zmushko, T.; Turuntaev, S. B.; Kulikov, V. I.

2012-04-01

The mine seismicity of Vorkuta coal deposit was analyzed. Seismic network consisting of 24 seismic sensors (accelerometers) cover the area of "Komsomolskaya" and "North" mines of Vorkuta deposit. Also there is seismic station of IDG RAS with three-component seismometer near this mines for better defining energy of the seismic events. The catalogs of seismic events contain 9000 and 7000 events with maximum magnitude M=2.3 for "Komsomolskaya" and "North" mines respectively and include the period from 01.09.2008 to 01.09.2011. The b-value of the magnitude-frequency relation was -1.0 and -1.15 respectively for the mines, meanwhile b-value for the nature seismicity was -0,9. It was found, that the number of seismic events per hour during mine combine operation is higher in 2.5 times than the number of seismic events during the break in the operation. Also, the total energy of the events per hour during the operation is higher in 3-5 times than during the break. The study showed, that the number and the energy of the seismic events relate with the hours of mine combine operation. The spatial distribution of the seismic events showed, that 80% of all events and 85% of strong events (M>1.6) were located in and near the longwall under development during the mine combine operations as well asduring the breaks. The isoclines of seismic event numbers proved that the direction of motion of the boundary of seismic events extension coincides with the direction of development, the maximum number of events for any period lies within the wall under operation. The rockburst with M=2.3 occurring at the North mine at July 16, 2011 was considered. The dependences of the energy and of the number of events with different magnitudes on the time showed that the number of events with M=1 and especially M=0.5 before the rockburst decreased, which corresponds to the prognostic seismic quietness, described in the research works. The spatial distribution of the events for the 6 month before the rockburst showed that the rockbust occurred at some distance from the main group of seismic events, in an area where the vent brake slope was made at that time. It was found that there is an area where the coal was not developed, but the seismic events occured. Such area could be noticed before the moment of the rockburst. The spatial distribution of the seismic events during the "seismic quietness" showed that for events with M = 1, and especially for the events with M = 0.5, the analogue of "seismic gap" (the area without events between the seismically active areas) can be noticed. The rockburst occurred at the boundary of the "seismic gap". Obtained results (which are in correspondence with known natural earthquake prediction phenomena) could be used for forecast of the considered rockburst in a 1 month before it occurred.

Multi-model ensemble projections of European river floods and high flows at 1.5, 2, and 3 degree global warming

NASA Astrophysics Data System (ADS)

Thober, S.; Kumar, R.; Wanders, N.; Marx, A.; Pan, M.; Rakovec, O.; Samaniego, L. E.; Sheffield, J.; Wood, E. F.; Zink, M.

2017-12-01

Severe river floods often result in huge economic losses and fatalities. Since 1980, almost 1500 such events have been reported in Europe. This study investigates climate change impacts on European floods under 1.5, 2, and 3 K global warming. The impacts are assessed employing a multi-model ensemble containing three hydrologic models (HMs: mHM, Noah-MP, PCR-GLOBWB) forced by five CMIP5 General Circulation Models (GCMs) under three Representative Concentration Pathways (RCPs 2.6, 6.0, and 8.5). This multi-model ensemble is unprecedented with respect to the combination of its size (45 realisations) and its spatial resolution, which is 5 km over entire Europe. Climate change impacts are quantified for high flows and flood events, represented by 10% exceedance probability and annual maxima of daily streamflow, respectively. The multi-model ensemble points to the Mediterranean region as a hotspot of changes with significant decrements in high flows from -11% at 1.5 K up to -30% at 3 K global warming mainly resulting from reduced precipitation. Small changes (< ±10%) are observed for river basins in Central Europe and the British Isles under different levels of warming. Projected higher annual precipitation increases high flows in Scandinavia, but reduced snow water equivalent decreases flood events in this region. The contribution by the GCMs to the overall uncertainties of the ensemble is in general higher than that by the HMs. The latter, however, have a substantial share of the overall uncertainty and exceed GCM uncertainty in the Mediterranean and Scandinavia. Adaptation measures for limiting the impacts of global warming could be similar under 1.5 K and 2 K global warming, but has to account for significantly higher changes under 3 K global warming.

Anesthesia in per-oral endoscopic myotomy: A large tertiary care centre experience.

PubMed

Darisetty, Santosh; Nabi, Zaheer; Ramchandani, Mohan; Chavan, Radhika; Kotla, Rama; Nageshwar Reddy, D

2017-07-01

Per-oral endoscopic myotomy (POEM) is safe and efficacious for the management of achalasia cardia (AC). POEM is usually performed under general anesthesia in an endoscopy suite or operating theatre. The current study was conducted with the aim to analyse anesthetic management of patients with AC who underwent POEM at our institution. We retrospectively analysed the data of patients with AC who underwent POEM at our institution from January 2013 to September 2016. All cases were performed in an endoscopy suite under supervision of an anesthesia management team. Pre-procedure endoscopic evacuation of esophagogastric contents was done in all cases. Management strategies used for gas-related adverse events and outcomes were assessed. Four hundred and eighty patients (median age 40 years, range 4-77 years) underwent POEM during the study period. The sub-types of AC were type I (163), type II (297), and type III (20). POEM was successfully completed in 97.5% patients. Gas-related events were noted in 30.6% cases including-capno-thorax in 1%, capno-peritoneum in 12.3%, retroperitoneal air in 16.5%, capno-mediastinum in 0.2%, and capno-pericardium in 0.4% patients. Significant rise in end tidal CO2 (> 45) and peak airway pressure were observed in 8.1% and 5.4% cases, respectively. Drainage was required in 12.3% patients. There was no occurrence of aspiration during or after POEM. POEM could be safely performed in an endoscopy suite under supervision of an expert anesthesia management team. Gas-related adverse events were common during POEM and could be managed with a standardized approach.

Sensitive indicators of Stipa bungeana response to precipitation under ambient and elevated CO2 concentration

NASA Astrophysics Data System (ADS)

Shi, Yaohui; Zhou, Guangsheng; Jiang, Yanling; Wang, Hui; Xu, Zhenzhu

2018-02-01

Precipitation is a primary environmental factor in the semiarid grasslands of northern China. With increased concentrations of atmospheric greenhouse gases, precipitation regimes will change, and high-impact weather events may be more common. Currently, many ecophysiological indicators are known to reflect drought conditions, but these indicators vary greatly among species, and few studies focus on the applicability of these drought indicators under high CO2 conditions. In this study, five precipitation levels (- 30%, - 15%, control, + 15%, and + 30%) were used to simulate the effects of precipitation change on 18 ecophysiological characteristics in Stipa bungeana, including leaf area, plant height, leaf nitrogen (N), and chlorophyll content, among others. Two levels of CO2 concentration (ambient, 390 ppm; 550 ppm) were used to simulate the effects of elevated CO2 on these drought indicators. Using gray relational analysis and phenotypic plasticity analysis, we found that total leaf area or leaf number (morphology), leaf water potential or leaf water content (physiology), and aboveground biomass better reflected the water status of S. bungeana under ambient and elevated CO2 than the 13 other analyzed variables. The sensitivity of drought indicators changed under the elevated CO2 condition. By quantifying the relationship between precipitation and the five most sensitive indicators, we found that the thresholds of precipitation decreased under elevated CO2 concentration. These results will be useful for objective monitoring and assessment of the occurrence and development of drought events in S. bungeana grasslands.

Real-time measurements, rare events and photon economics

NASA Astrophysics Data System (ADS)

Jalali, B.; Solli, D. R.; Goda, K.; Tsia, K.; Ropers, C.

2010-07-01

Rogue events otherwise known as outliers and black swans are singular, rare, events that carry dramatic impact. They appear in seemingly unconnected systems in the form of oceanic rogue waves, stock market crashes, evolution, and communication systems. Attempts to understand the underlying dynamics of such complex systems that lead to spectacular and often cataclysmic outcomes have been frustrated by the scarcity of events, resulting in insufficient statistical data, and by the inability to perform experiments under controlled conditions. Extreme rare events also occur in ultrafast physical sciences where it is possible to collect large data sets, even for rare events, in a short time period. The knowledge gained from observing rare events in ultrafast systems may provide valuable insight into extreme value phenomena that occur over a much slower timescale and that have a closer connection with human experience. One solution is a real-time ultrafast instrument that is capable of capturing singular and randomly occurring non-repetitive events. The time stretch technology developed during the past 13 years is providing a powerful tool box for reaching this goal. This paper reviews this technology and discusses its use in capturing rogue events in electronic signals, spectroscopy, and imaging. We show an example in nonlinear optics where it was possible to capture rare and random solitons whose unusual statistical distribution resemble those observed in financial markets. The ability to observe the true spectrum of each event in real time has led to important insight in understanding the underlying process, which in turn has made it possible to control soliton generation leading to improvement in the coherence of supercontinuum light. We also show a new class of fast imagers which are being considered for early detection of cancer because of their potential ability to detect rare diseased cells (so called rogue cells) in a large population of healthy cells.

Multilevel joint competing risk models

NASA Astrophysics Data System (ADS)

Karunarathna, G. H. S.; Sooriyarachchi, M. R.

2017-09-01

Joint modeling approaches are often encountered for different outcomes of competing risk time to event and count in many biomedical and epidemiology studies in the presence of cluster effect. Hospital length of stay (LOS) has been the widely used outcome measure in hospital utilization due to the benchmark measurement for measuring multiple terminations such as discharge, transferred, dead and patients who have not completed the event of interest at the follow up period (censored) during hospitalizations. Competing risk models provide a method of addressing such multiple destinations since classical time to event models yield biased results when there are multiple events. In this study, the concept of joint modeling has been applied to the dengue epidemiology in Sri Lanka, 2006-2008 to assess the relationship between different outcomes of LOS and platelet count of dengue patients with the district cluster effect. Two key approaches have been applied to build up the joint scenario. In the first approach, modeling each competing risk separately using the binary logistic model, treating all other events as censored under the multilevel discrete time to event model, while the platelet counts are assumed to follow a lognormal regression model. The second approach is based on the endogeneity effect in the multilevel competing risks and count model. Model parameters were estimated using maximum likelihood based on the Laplace approximation. Moreover, the study reveals that joint modeling approach yield more precise results compared to fitting two separate univariate models, in terms of AIC (Akaike Information Criterion).

Intra-seasonal variability of extreme boreal stratospheric polar vortex events and their precursors

NASA Astrophysics Data System (ADS)

Díaz-Durán, Adelaida; Serrano, Encarna; Ayarzagüena, Blanca; Abalos, Marta; de la Cámara, Alvaro

2017-11-01

The dynamical variability of the boreal stratospheric polar vortex has been usually analysed considering the extended winter as a whole or only focusing on December, January and February. Yet recent studies have found intra-seasonal differences in the boreal stratospheric dynamics. In this study, the intra-seasonal variability of anomalous wave activity preceding polar vortex extremes in the Northern Hemisphere is examined using ERA-Interim reanalysis data. Weak (WPV) and strong (SPV) polar vortex events are grouped into early, mid- or late winter sub-periods depending on the onset date. Overall, the strongest (weakest) wave-activity anomalies preceding polar vortex extremes are found in mid- (early) winter. Most of WPV (SPV) events in early winter occur under the influence of east (west) phase of the Quasi-Biennial Oscillation (QBO) and an enhancement (inhibition) of wavenumber-1 wave activity (WN1). Mid- and late winter WPV events are preceded by a strong vortex and an enhancement of WN1 and WN2, but the spatial structure of the anomalous wave activity and the phase of the QBO are different. Prior to mid-winter WPVs the enhancement of WN2 is related to the predominance of La Niña and linked to blockings over Siberia. Mid-winter SPV events show a negative phase of the Pacific-North America pattern that inhibits WN1 injected into the stratosphere. This study suggests that dynamical features preceding extreme polar vortex events in mid-winter should not be generalized to other winter sub-periods.

Analysis of the adverse events reported to the office of the clinical director at a dental school in Bogotá, Colombia.

PubMed

Huertas, María F; Gonzalez, Juliana; Camacho, Sandra; Sarralde, Ana L; Rodríguez, Adriana

2017-04-01

Dentistry is interested in identifying and controlling adverse events, understood as involuntary injuries to the patient during dental care. The aim of this study was to analyze the adverse events reported to the Office of the Clinical Director at the School of Dentistry at Pontificia Universidad Javeriana (Colombia) during 2011-2012. It was an observational, descriptive study that evaluated 227 dental clinical records of patients who filed a complaint with the Office of the Clinical Director. Of these, 43 were adverse events and were used as the basis for this study. Of the 16,060 patients who received care during 2011 - 2012, 0.26% (43) filed a complaint involving an adverse event, of which 97.7 % were considered preventable. Most of these (76.18%, n= 32) occurred during clinical management of treatments in different specialties, 9.5% (4) were the result of deficient external dental laboratory quality, and 14.32% (6) were due to failure in document management, soft tissue injury, misdiagnosis and swallowing foreign objects. Of the patients involved, 65.2% (28) received care from postgraduate students, with the highest number of cases in the Oral Rehabilitation speciality. The occurrence of adverse events during dental care, indicates the need for information about their origin in order to establish protection barriers and prevent their incidence, particularly in the educational area under the student dental clinic service model. Sociedad Argentina de Investigación Odontológica.

Acute neurovascular events in cancer patients receiving anti-vascular endothelial growth factor agents: Clinical experience in Paris University Hospitals.

PubMed

Tlemsani, Camille; Mir, Olivier; Psimaras, Dimitri; Vano, Yann-Alexandre; Ducreux, Michel; Escudier, Bernard; Rousseau, Benoit; Loirat, Delphine; Ceccaldi, Bernard; André, Thierry; Goldwasser, François; Ricard, Damien

2016-10-01

Despite the increasing and broadening use of agents targeting the vascular endothelial growth factor (VEGF) pathway, little is known on their acute neurovascular toxicities. This retrospective, multi-centre study examined the characteristics of patients with solid tumours who experienced an ischaemic or haemorrhagic stroke, a transient ischaemic accident (TIA) or a posterior reversible encephalopathy syndrome (PRES) while under anti-VEGF and until 8 weeks after termination of treatment and evaluated their management in our institutions from 2004 to 2014. Patients with newly diagnosed or progressive cerebral metastases at the time of the acute neurovascular event were excluded. Thirty-four patients (55.9% men) were identified, and experienced either ischaemic stroke (n = 18), PRES (n = 9), TIA (n = 6) or haemorrhagic stroke (n = 1). At initiation of anti-VEGF agents, 64.7% of patients had previous cardiovascular risk factors, and 52.9% had hypertension. Eight patients (23.5%) had received cerebral radiotherapy, five of which concomitantly to anti-VEGF treatment. Six (17%) patients died in the 8 weeks following the acute neurovascular event, and only 55.9% recovered their initial neurological status. Overall, 1-year and 2-year survival rates after the acute neurovascular event were 67.9% and 50%, respectively. When anti-VEGF agents were reintroduced (n = 6), severe vascular toxicity recurred in two patients. Neurovascular events under VEGF treatments are potentially severe, and the management of comorbid conditions has to be improved. A prospective collection of data and standardised management of such events is therefore being structured in our institutions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Answering Questions about Complex Events

DTIC Science & Technology

2008-12-19

in their environment. To reason about events requires a means of describing, simulating, and analyzing their underlying dynamic processes . For our...that are relevant to our goal of connecting inference and reasoning about processes to answering questions about events. 11 We start with a...different event and process descriptions, ontologies, and models. 2.1.1 Logical AI In AI, formal approaches to model the ability to reason about

40 CFR 270.235 - Options for incinerators, cement kilns, lightweight aggregate kilns, solid fuel boilers, liquid...

Code of Federal Regulations, 2014 CFR

2014-07-01

... to minimize emissions from startup, shutdown, and malfunction events. 270.235 Section 270.235... from startup, shutdown, and malfunction events. (a) Facilities with existing permits—(1) Revisions to... from startup, shutdown, and malfunction events under any of the following options when requesting...

40 CFR 270.235 - Options for incinerators, cement kilns, lightweight aggregate kilns, solid fuel boilers, liquid...

Code of Federal Regulations, 2012 CFR

2012-07-01

... to minimize emissions from startup, shutdown, and malfunction events. 270.235 Section 270.235... from startup, shutdown, and malfunction events. (a) Facilities with existing permits—(1) Revisions to... from startup, shutdown, and malfunction events under any of the following options when requesting...

40 CFR 270.235 - Options for incinerators, cement kilns, lightweight aggregate kilns, solid fuel boilers, liquid...

Code of Federal Regulations, 2011 CFR

2011-07-01

... to minimize emissions from startup, shutdown, and malfunction events. 270.235 Section 270.235... from startup, shutdown, and malfunction events. (a) Facilities with existing permits—(1) Revisions to... from startup, shutdown, and malfunction events under any of the following options when requesting...

40 CFR 270.235 - Options for incinerators, cement kilns, lightweight aggregate kilns, solid fuel boilers, liquid...

Code of Federal Regulations, 2013 CFR

2013-07-01

... to minimize emissions from startup, shutdown, and malfunction events. 270.235 Section 270.235... from startup, shutdown, and malfunction events. (a) Facilities with existing permits—(1) Revisions to... from startup, shutdown, and malfunction events under any of the following options when requesting...

14 CFR 381.9 - Sales.

Code of Federal Regulations, 2010 CFR

2010-01-01

... agent to accept such money, unless the operator has physical possession of, or written contracts (in the... possession of or written contracts for a ticket for admission to the event, any payment accompanying that... it has event tickets in hand or under contract. (An operator need not continue to reserve an event...

Age Regression in the Treatment of Anger in a Prison Setting.

ERIC Educational Resources Information Center

Eisel, Harry E.

1988-01-01

Incorporated hypnotherapy with age regression into cognitive therapeutic approach with prisoners having history of anger. Technique involved age regression to establish first significant event causing current anger, catharsis of feelings for original event, and reorientation of event while under hypnosis. Results indicated decrease in acting-out…

Monitoring potential adverse event rate differences using data from blinded trials: the canary in the coal mine.

PubMed

Gould, A Lawrence; Wang, William B

2017-01-15

The development of drugs and biologicals whose mechanisms of action may extend beyond their target indications has led to a need to identify unexpected potential toxicities promptly even while blinded clinical trials are under way. One component of recently issued FDA rules regarding safety reporting requirements raises the possibility of breaking the blind for pre-identified serious adverse events that are not the clinical endpoints of a blinded study. Concern has been expressed that unblinding individual cases of frequently occurring adverse events could compromise the overall validity of the study. However, if external information is available about adverse event rates among patients not receiving the test product in populations similar to the study population, then it may be possible to address the potential for elevated risk without unblinding the trial. This article describes a Bayesian approach for determining the likelihood of elevated risk suitable binomial or Poisson likelihoods that applies regardless of the metric used to express the difference. The method appears to be particularly appropriate for routine monitoring of safety information for project development programs that include large blinded trials. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Flood evolution assessment and monitoring using hydrological modelling techniques: analysis of the inundation areas at a regional scale

NASA Astrophysics Data System (ADS)

Podhoranyi, M.; Kuchar, S.; Portero, A.

2016-08-01

The primary objective of this study is to present techniques that cover usage of a hydrodynamic model as the main tool for monitoring and assessment of flood events while focusing on modelling of inundation areas. We analyzed the 2010 flood event (14th May - 20th May) that occurred in the Moravian-Silesian region (Czech Republic). Under investigation were four main catchments: Opava, Odra, Olše and Ostravice. Four hydrodynamic models were created and implemented into the Floreon+ platform in order to map inundation areas that arose during the flood event. In order to study the dynamics of the water, we applied an unsteady flow simulation for the entire area (HEC-RAS 4.1). The inundation areas were monitored, evaluated and recorded semi-automatically by means of the Floreon+ platform. We focused on information about the extent and presence of the flood areas. The modeled flooded areas were verified by comparing them with real data from different sources (official reports, aerial photos and hydrological networks). The study confirmed that hydrodynamic modeling is a very useful tool for mapping and monitoring of inundation areas. Overall, our models detected 48 inundation areas during the 2010 flood event.

Episodic and semantic components of autobiographical memories and imagined future events in post-traumatic stress disorder.

PubMed

Brown, Adam D; Addis, Donna Rose; Romano, Tracy A; Marmar, Charles R; Bryant, Richard A; Hirst, William; Schacter, Daniel L

2014-01-01

Individuals with post-traumatic stress disorder (PTSD) tend to retrieve autobiographical memories with less episodic specificity, referred to as overgeneralised autobiographical memory. In line with evidence that autobiographical memory overlaps with one's capacity to imagine the future, recent work has also shown that individuals with PTSD also imagine themselves in the future with less episodic specificity. To date most studies quantify episodic specificity by the presence of a distinct event. However, this method does not distinguish between the numbers of internal (episodic) and external (semantic) details, which can provide additional insights into remembering the past and imagining the future. This study employed the Autobiographical Interview (AI) coding scheme to the autobiographical memory and imagined future event narratives generated by combat veterans with and without PTSD. Responses were coded for the number of internal and external details. Compared to combat veterans without PTSD, those with PTSD generated more external than internal details when recalling past or imagining future events, and fewer internal details were associated with greater symptom severity. The potential mechanisms underlying these bidirectional deficits and clinical implications are discussed.

Post-event processing in social anxiety disorder after real-life social situations - An ambulatory assessment study.

PubMed

Helbig-Lang, Sylvia; von Auer, Maxie; Neubauer, Karolin; Murray, Eileen; Gerlach, Alexander L

2016-09-01

Excessive post-mortem processing after social situations, a core symptom of social anxiety disorder (SAD), is thought to contribute to the perpetuation of social anxiety by consolidating negative self-schemata. Empirical findings on actual mechanisms underlying this so-called Post-Event Processing (PEP) are still scarce. The present study sought to identify variables associated with the experience of PEP after real-life social situations in a sample of 49 individuals diagnosed with SAD. Using an ambulatory assessment approach, individuals were asked to report on each distressing social event experienced during one week. A total of 192 events were captured. Hierarchical linear modeling indicated that next to trait social anxiety, the type of social situation (performance vs. interaction situations), self-focused attention, safety behavior use, and negative affect predicted levels of PEP after social situations. These findings add to the growing literature that emphasizes the importance of situational factors for the experience of PEP, and highlight potential venues to prevent it. Copyright © 2016 Elsevier Ltd. All rights reserved.

An experimental overview of the seismic cycle

NASA Astrophysics Data System (ADS)

Spagnuolo, E.; Violay, M.; Passelegue, F. X.; Nielsen, S. B.; Di Toro, G.

2017-12-01

Earthquake nucleation is the last stage of the inter-seismic cycle where the fault surface evolves through the interplay of friction, healing, stress perturbations and strain events. Slip stability under rate-and state friction has been extensively discussed in terms of loading point velocity and equivalent fault stiffness, but fault evolution towards seismic runaway under complex loading histories (e.g. slow variations of tectonic stress, stress transfer from impulsive nearby seismic events) is not yet fully investigated. Nevertheless, the short term earthquake forecasting is based precisely on a relation between seismic productivity and loading history which remains up to date still largely unresolved. To this end we propose a novel experimental approach which avails of a closed loop control of the shear stress, a nominally infinite equivalent slip and transducers for continuous monitoring of acoustic emissions. This experimental simulation allows us to study the stress dependency and temporal evolution of spontaneous slip events occurring on a pre-existing fault subjected to different loading histories. The experimental fault has an initial roughness which mimic a population of randomly distributed asperities, which here are used as a proxy for patches which are either far or close to failure on an extended fault. Our observations suggest that the increase of shear stress may trigger either spontaneous slow slip (creep) or short-lived stick-slip bursts, eventually leading to a fast slip instability (seismic runaway) when slip rates are larger than a few cm/s. The event type and the slip rate are regulated at first order by the background shear stress whereas the ultimate strength of the entire fault is dominated by the number of asperities close to failure under a stress step. The extrapolation of these results to natural conditions might explain the plethora of events that often characterize seismic sequences. Nonetheless this experimental approach helps the definition of a scaling relation between the loading rate and cumulated slip which is relevant to the definition of a recurrence model for the seismic cycle.

Biodegradable stent or balloon dilatation for benign oesophageal stricture: pilot randomised controlled trial.

PubMed

Dhar, Anjan; Close, Helen; Viswanath, Yirupaiahgari K; Rees, Colin J; Hancock, Helen C; Dwarakanath, A Deepak; Maier, Rebecca H; Wilson, Douglas; Mason, James M

2014-12-28

To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures. This British multi-site study recruited seventeen symptomatic adult patients with refractory strictures. Patients were randomised using a multicentre, blinded assessor design, comparing a biodegradable stent (BS) with endoscopic dilatation (ED). The primary endpoint was the average dysphagia score during the first 6 mo. Secondary endpoints included repeat endoscopic procedures, quality of life, and adverse events. Secondary analysis included follow-up to 12 mo. Sensitivity analyses explored alternative estimation methods for dysphagia and multiple imputation of missing values. Nonparametric tests were used. Although both groups improved, the average dysphagia scores for patients receiving stents were higher after 6 mo: BS-ED 1.17 (95%CI: 0.63-1.78) P = 0.029. The finding was robust under different estimation methods. Use of additional endoscopic procedures and quality of life (QALY) estimates were similar for BS and ED patients at 6 and 12 mo. Concomitant use of gastrointestinal prescribed medication was greater in the stent group (BS 5.1, ED 2.0 prescriptions; P < 0.001), as were related adverse events (BS 1.4, ED 0.0 events; P = 0.024). Groups were comparable at baseline and findings were statistically significant but numbers were small due to under-recruitment. The oesophageal tract has somatic sensitivity and the process of the stent dissolving, possibly unevenly, might promote discomfort or reflux. Stenting was associated with greater dysphagia, co-medication and adverse events. Rigorously conducted and adequately powered trials are needed before widespread adoption of this technology.

Biodegradable stent or balloon dilatation for benign oesophageal stricture: Pilot randomised controlled trial

PubMed Central

Dhar, Anjan; Close, Helen; Viswanath, Yirupaiahgari K; Rees, Colin J; Hancock, Helen C; Dwarakanath, A Deepak; Maier, Rebecca H; Wilson, Douglas; Mason, James M

2014-01-01

AIM: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures. METHODS: This British multi-site study recruited seventeen symptomatic adult patients with refractory strictures. Patients were randomised using a multicentre, blinded assessor design, comparing a biodegradable stent (BS) with endoscopic dilatation (ED). The primary endpoint was the average dysphagia score during the first 6 mo. Secondary endpoints included repeat endoscopic procedures, quality of life, and adverse events. Secondary analysis included follow-up to 12 mo. Sensitivity analyses explored alternative estimation methods for dysphagia and multiple imputation of missing values. Nonparametric tests were used. RESULTS: Although both groups improved, the average dysphagia scores for patients receiving stents were higher after 6 mo: BS-ED 1.17 (95%CI: 0.63-1.78) P = 0.029. The finding was robust under different estimation methods. Use of additional endoscopic procedures and quality of life (QALY) estimates were similar for BS and ED patients at 6 and 12 mo. Concomitant use of gastrointestinal prescribed medication was greater in the stent group (BS 5.1, ED 2.0 prescriptions; P < 0.001), as were related adverse events (BS 1.4, ED 0.0 events; P = 0.024). Groups were comparable at baseline and findings were statistically significant but numbers were small due to under-recruitment. The oesophageal tract has somatic sensitivity and the process of the stent dissolving, possibly unevenly, might promote discomfort or reflux. CONCLUSION: Stenting was associated with greater dysphagia, co-medication and adverse events. Rigorously conducted and adequately powered trials are needed before widespread adoption of this technology. PMID:25561787

Optimizing preplant irrigation for maize under limited water in the High Plains

USDA-ARS?s Scientific Manuscript database

Due to inadequate well capacities, many farmers cannot meet inseason crop evapotranspiration demands. Some farmers apply preplant (preseason) irrigation to buffer the crop between irrigation or rainfall events during the season. A simulation study was conducted to assess the effect of preplant irrig...

Music Training and Working Memory: An ERP Study

ERIC Educational Resources Information Center

George, Elyse M.; Coch, Donna

2011-01-01

While previous research has suggested that music training is associated with improvements in various cognitive and linguistic skills, the mechanisms mediating or underlying these associations are mostly unknown. Here, we addressed the hypothesis that previous music training is related to improved working memory. Using event-related potentials…

Utility of social media and crowd-sourced data for pharmacovigilance: a scoping review protocol.

PubMed

Tricco, Andrea C; Zarin, Wasifa; Lillie, Erin; Pham, Ba; Straus, Sharon E

2017-01-19

Adverse events associated with medications are under-reported in postmarketing surveillance systems. A systematic review of published data from 37 studies worldwide (including Canada) found the median under-reporting rate of adverse events to be 94% in spontaneous reporting systems. This scoping review aims to assess the utility of social media and crowd-sourced data to detect and monitor adverse events related to health products including pharmaceuticals, medical devices, biologics and natural health products. Our review conduct will follow the Joanna Briggs Institute scoping review methods manual. Literature searches were conducted in MEDLINE, EMBASE and the Cochrane Library from inception to 13 May 2016. Additional sources included searches of study registries, conference abstracts, dissertations, as well as websites of international regulatory authorities (eg, Food and Drug Administration (FDA), the WHO, European Medicines Agency). Search results will be supplemented by scanning the references of relevant reviews. We will include all publication types including published articles, editorials, websites and book sections that describe use of social media and crowd-sourced data for surveillance of adverse events associated with health products. Two reviewers will perform study selection and data abstraction independently, and discrepancies will be resolved through discussion. Data analysis will involve quantitative (eg, frequencies) and qualitative (eg, content analysis) methods. The summary of results will be sent to Health Canada, who commissioned the review, and other relevant policymakers involved with the Drug Safety and Effectiveness Network. We will compile and circulate a 1-page policy brief and host a 1-day stakeholder meeting to discuss the implications, key messages and finalise the knowledge translation strategy. Findings from this review will ultimately inform the design and development of a data analytics platform for social media and crowd-sourced data for pharmacovigilance in Canada and internationally. Our protocol was registered prospectively with the Open Science Framework (https://osf.io/kv9hu/). Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Characterization of extreme precipitation within atmospheric river events over California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeon, S.; Prabhat,; Byna, S.

Atmospheric rivers (ARs) are large, spatially coherent weather systems with high concentrations of elevated water vapor. These systems often cause severe downpours and flooding over the western coastal United States – and with the availability of more atmospheric moisture in the future under global warming we expect ARs to play an important role as potential causes of extreme precipitation changes. Therefore, we aim to investigate changes in extreme precipitation properties correlated with AR events in a warmer climate, which are large-scale meteorological patterns affecting the weather and climate of California. We have recently developed the TECA (Toolkit for Extreme Climatemore » Analysis) software for automatically identifying and tracking features in climate data sets. Specifically, we can now identify ARs that make landfall on the western coast of North America. Based on this detection procedure, we can investigate the impact of ARs by exploring the spatial extent of AR precipitation using climate model (CMIP5) simulations and characterize spatial patterns of dependence for future projections between AR precipitation extremes under climate change within the statistical framework. Our results show that AR events in the future RCP (Representative Concentration Pathway)8.5 scenario (2076–2100) tend to produce heavier rainfall with higher frequency and longer days than events from the historical run (1981–2005). We also find that the dependence between extreme precipitation events has a shorter spatial range, within localized areas in California, under the high future emissions scenario than under the historical run.« less

Characterization of extreme precipitation within atmospheric river events over California

DOE PAGES

Jeon, S.; Prabhat,; Byna, S.; ...

2015-11-17

Atmospheric rivers (ARs) are large, spatially coherent weather systems with high concentrations of elevated water vapor. These systems often cause severe downpours and flooding over the western coastal United States – and with the availability of more atmospheric moisture in the future under global warming we expect ARs to play an important role as potential causes of extreme precipitation changes. Therefore, we aim to investigate changes in extreme precipitation properties correlated with AR events in a warmer climate, which are large-scale meteorological patterns affecting the weather and climate of California. We have recently developed the TECA (Toolkit for Extreme Climatemore » Analysis) software for automatically identifying and tracking features in climate data sets. Specifically, we can now identify ARs that make landfall on the western coast of North America. Based on this detection procedure, we can investigate the impact of ARs by exploring the spatial extent of AR precipitation using climate model (CMIP5) simulations and characterize spatial patterns of dependence for future projections between AR precipitation extremes under climate change within the statistical framework. Our results show that AR events in the future RCP (Representative Concentration Pathway)8.5 scenario (2076–2100) tend to produce heavier rainfall with higher frequency and longer days than events from the historical run (1981–2005). We also find that the dependence between extreme precipitation events has a shorter spatial range, within localized areas in California, under the high future emissions scenario than under the historical run.« less

Single Intravenous Dose of Oritavancin for Treatment of Acute Skin and Skin Structure Infections Caused by Gram-Positive Bacteria: Summary of Safety Analysis from the Phase 3 SOLO Studies.

PubMed

Corey, G Ralph; Loutit, Jeffery; Moeck, Greg; Wikler, Matthew; Dudley, Michael N; O'Riordan, William

2018-04-01

Oritavancin is a lipoglycopeptide with bactericidal activity against Gram-positive organisms. Its rapid concentration-dependent bactericidal activity and long elimination half-life allow single-dose treatment of acute bacterial skin and skin structure infections (ABSSSI). SOLO I and SOLO II were randomized, double-blind studies evaluating the efficacy and safety of a single 1,200-mg intravenous (i.v.) dose of oritavancin versus twice-daily i.v. vancomycin for 7 to 10 days in ABSSSI patients. Safety data from both studies were pooled for safety analysis. The database comprised pooled safety data for 976 oritavancin-treated patients and 983 vancomycin-treated patients. The incidences of adverse events, serious adverse events, and discontinuations due to adverse events were similar for oritavancin (55.3, 5.8, and 3.7%, respectively) and vancomycin (56.9, 5.9, and 4.2%, respectively). The median time to onset (3.8 days versus 3.1 days, respectively) and the duration (3.0 days for both groups) of adverse events were also similar between the two groups. The most frequently reported events were nausea, headache, and vomiting. Greater than 90% of all events were mild or moderate in severity. There were slightly more infections and infestations, abscesses or cellulitis, and hepatic and cardiac adverse events in the oritavancin group; however, more than 80% of these events were mild or moderate. Subgroup analyses did not identify clinically meaningful differences in the incidence of adverse events attributed to oritavancin. A single 1,200-mg dose of oritavancin was well tolerated and had a safety profile similar to that of twice-daily vancomycin. The long elimination half-life of oritavancin compared to that of vancomycin did not result in a clinically meaningful delay to the onset or prolongation of adverse events. (This study has been registered at ClinicalTrials.gov under registration no. NCT01252719 and NCT01252732.). Copyright © 2018 American Society for Microbiology.

Estimating drought induced tree mortality in the Amazon rainforest: A simulation study with a focus on plant hydraulic processes

NASA Astrophysics Data System (ADS)

Papastefanou, P.; Fleischer, K.; Hickler, T.; Grams, T.; Lapola, D.; Quesada, C. A.; Zang, C.; Rammig, A.

2017-12-01

The Amazon basin was recently hit by severe drought events that were unprecedented in their severity and spatial extent, e.g. during 2005, 2010 and 2015/2016. Significant amounts of biomass were lost, turning large parts of the rainforest from a carbon sink into a carbon source. It is assumed that drought-induced tree mortality from hydraulic failure played an important role during these events and may become more frequent in the Amazon region in the future. Many state-of-the-art dynamic vegetation models do not include plant hydraulic processes and fail to reproduce observed rainforest responses to drought events, such as e.g. increased tree mortality. We address this research gap by developing a simple plant-hydraulic module for the dynamic vegetation model LPJ-GUESS. This plant-hydraulic module uses leaf water potential and cavitation as baseline processes to simulate tree mortality under drought stress. Furthermore, we introduce different plant strategies in the model, which describe e.g. differences in the stomatal regulation under drought stress. To parameterize and evaluate our hydraulic module, we use a set of available observational data from the Amazon region. We apply our model to the Amazon Basin and highlight similarities and differences across other measured and predicted drought responses, e.g. extrapolated observations and data derived from satellite measurements. Our results highlight the importance of including plant hydraulic processes in dynamic vegetation models to correctly predict vegetation dynamics under drought stress and show major differences on the vegetation dynamics depending on the selected plant strategies. We also identify gaps in process understanding of the triggering factors, the extent and the consequences of drought responses that hampers our ability to predict potential impact of future drought events on the Amazon rainforest.

A Fusion Model of Seismic and Hydro-Acoustic Propagation for Treaty Monitoring

NASA Astrophysics Data System (ADS)

Arora, Nimar; Prior, Mark

2014-05-01

We present an extension to NET-VISA (Network Processing Vertically Integrated Seismic Analysis), which is a probabilistic generative model of the propagation of seismic waves and their detection on a global scale, to incorporate hydro-acoustic data from the IMS (International Monitoring System) network. The new model includes the coupling of seismic waves into the ocean's SOFAR channel, as well as the propagation of hydro-acoustic waves from underwater explosions. The generative model is described in terms of multiple possible hypotheses -- seismic-to-hydro-acoustic, under-water explosion, other noise sources such as whales singing or icebergs breaking up -- that could lead to signal detections. We decompose each hypothesis into conditional probability distributions that are carefully analyzed and calibrated. These distributions include ones for detection probabilities, blockage in the SOFAR channel (including diffraction, refraction, and reflection around obstacles), energy attenuation, and other features of the resulting waveforms. We present a study of the various features that are extracted from the hydro-acoustic waveforms, and their correlations with each other as well the source of the energy. Additionally, an inference algorithm is presented that concurrently infers the seismic and under-water events, and associates all arrivals (aka triggers), both from seismic and hydro-acoustic stations, to the appropriate event, and labels the path taken by the wave. Finally, our results demonstrate that this fusion of seismic and hydro-acoustic data leads to very good performance. A majority of the under-water events that IDC (International Data Center) analysts built in 2010 are correctly located, and the arrivals that correspond to seismic-to-hydroacoustic coupling, the T phases, are mostly correctly identified. There is no loss in the accuracy of seismic events, in fact, there is a slight overall improvement.

Impact of Extreme Heat Events on Emergency Department Visits in North Carolina (2007-2011).

PubMed

Fuhrmann, Christopher M; Sugg, Margaret M; Konrad, Charles E; Waller, Anna

2016-02-01

Extreme heat is the leading cause of weather-related mortality in the U.S. Extreme heat also affects human health through heat stress and can exacerbate underlying medical conditions that lead to increased morbidity and mortality. In this study, data on emergency department (ED) visits for heat-related illness (HRI) and other selected diseases were analyzed during three heat events across North Carolina from 2007 to 2011. These heat events were identified based on the issuance and verification of heat products from local National Weather Service forecast offices (i.e. Heat Advisory, Heat Watch, and Excessive Heat Warning). The observed number of ED visits during these events were compared to the expected number of ED visits during several control periods to determine excess morbidity resulting from extreme heat. All recorded diagnoses were analyzed for each ED visit, thereby providing insight into the specific pathophysiological mechanisms and underlying health conditions associated with exposure to extreme heat. The most common form of HRI was heat exhaustion, while the percentage of visits with heat stroke was relatively low (<10%). The elderly (>65 years of age) were at greatest risk for HRI during the early summer heat event (8.9 visits per 100,000), while young and middle age adults (18-44 years of age) were at greatest risk during the mid-summer event (6.3 visits per 100,000). Many of these visits were likely due to work-related exposure. The most vulnerable demographic during the late summer heat event was adolescents (15-17 years of age), which may relate to the timing of organized sports. This demographic also exhibited the highest visit rate for HRI among all three heat events (10.5 visits per 100,000). Significant increases (p < 0.05) in visits with cardiovascular and cerebrovascular diseases were noted during the three heat events (3-8%). The greatest increases were found in visits with hypotension during the late summer event (23%) and sequelae during the early summer event (30%), while decreases were noted for visits with hemorrhagic stroke during the middle and late summer events (13-24%) and for visits with aneurysm during the early summer event (15%). Significant increases were also noted in visits with respiratory diseases (5-7%). The greatest increases in this category were found in visits with pneumonia and influenza (16%), bronchitis and emphysema (12%), and COPD (14%) during the early summer event. Significant increases in visits with nervous system disorders were also found during the early summer event (16%), while increases in visits with diabetes were noted during the mid-summer event (10%).

Sex under the influence of drugs or alcohol: common for men in substance abuse treatment and associated with high-risk sexual behavior.

PubMed

Calsyn, Donald A; Cousins, Sarah J; Hatch-Maillette, Mary A; Forcehimes, Alyssa; Mandler, Raul; Doyle, Suzanne R; Woody, George

2010-01-01

Sex under the influence of drugs or alcohol is associated with high-risk sexual behavior. Heterosexual men (n = 505) in substance abuse treatment completed a computer-administered interview assessing sexual risk behaviors. Most men (73.3%) endorsed sex under the influence in the prior 90 days, and 39.1% endorsed sex under the influence during their most recent sexual event. Sex under the influence at the most recent event was more likely to involve anal intercourse, sex with a casual partner, and less condom use. Patients might benefit from interventions targeting sexual behavior and substance use as mutual triggers. (Am J Addict 2010;00:1-9).

Hypoglycemia Reduction and Changes in Hemoglobin A1c in the ASPIRE In-Home Study.

PubMed

Weiss, Ram; Garg, Satish K; Bode, Bruce W; Bailey, Timothy S; Ahmann, Andrew J; Schultz, Kenneth A; Welsh, John B; Shin, John J

2015-08-01

ASPIRE In-Home randomized 247 subjects with type 1 diabetes to sensor-augmented pump therapy with or without the Threshold Suspend (TS) feature, which interrupts insulin delivery at a preset sensor glucose value. We studied the effects of TS on nocturnal hypoglycemia (NH) in relation to baseline hemoglobin A1c (A1C) and change in A1C during the study. NH event rates and mean area under curve (AUC) of NH events were evaluated at different levels of baseline A1C (<7%, 7-8%, and >8%) and at different levels of changes in A1C (less than -0.3% [decreased], -0.3% to 0.3% [stable], and >0.3% [increased]), in the TS Group compared with the Control Group (sensor-augmented pump only). In the TS Group, 27.9% of the NH events were accompanied by a confirmatory blood glucose value, compared with 39.3% in the Control Group. Among subjects with baseline A1C levels of <7% or 7-8%, those in the TS Group had significantly lower NH event rates than those in the Control Group (P=0.001 and P=0.004, respectively). Among subjects with decreased or stable A1C levels, those in the TS Group had significantly lower NH event rates, and the events had lower AUCs (P≤0.001 for each). Among subjects with increased A1C levels, those in the TS Group had NH events with significantly lower AUCs (P<0.001). Use of the TS feature was associated with decreases in the rate and severity (as measured by AUC) of NH events in many subjects, including those with low baseline A1C levels and those whose A1C values decreased during the study period. Use of the TS feature can help protect against hypoglycemia in those wishing to intensify diabetes management to achieve target glucose levels.

Hypoglycemia Reduction and Changes in Hemoglobin A1c in the ASPIRE In-Home Study

PubMed Central

Weiss, Ram; Garg, Satish K.; Bode, Bruce W.; Bailey, Timothy S.; Ahmann, Andrew J.; Schultz, Kenneth A.; Welsh, John B.

2015-01-01

Abstract Background: ASPIRE In-Home randomized 247 subjects with type 1 diabetes to sensor-augmented pump therapy with or without the Threshold Suspend (TS) feature, which interrupts insulin delivery at a preset sensor glucose value. We studied the effects of TS on nocturnal hypoglycemia (NH) in relation to baseline hemoglobin A1c (A1C) and change in A1C during the study. Materials and Methods: NH event rates and mean area under curve (AUC) of NH events were evaluated at different levels of baseline A1C (<7%, 7–8%, and >8%) and at different levels of changes in A1C (less than −0.3% [decreased], −0.3% to 0.3% [stable], and >0.3% [increased]), in the TS Group compared with the Control Group (sensor-augmented pump only). Results: In the TS Group, 27.9% of the NH events were accompanied by a confirmatory blood glucose value, compared with 39.3% in the Control Group. Among subjects with baseline A1C levels of <7% or 7–8%, those in the TS Group had significantly lower NH event rates than those in the Control Group (P=0.001 and P=0.004, respectively). Among subjects with decreased or stable A1C levels, those in the TS Group had significantly lower NH event rates, and the events had lower AUCs (P≤0.001 for each). Among subjects with increased A1C levels, those in the TS Group had NH events with significantly lower AUCs (P<0.001). Conclusions: Use of the TS feature was associated with decreases in the rate and severity (as measured by AUC) of NH events in many subjects, including those with low baseline A1C levels and those whose A1C values decreased during the study period. Use of the TS feature can help protect against hypoglycemia in those wishing to intensify diabetes management to achieve target glucose levels. PMID:26237308

A Numerical Study of Convection in a Condensing CO2 Atmosphere under Early Mars-Like Conditions

NASA Astrophysics Data System (ADS)

Nakajima, Kensuke; Yamashita, Tatsuya; Odaka, Masatsugu; Sugiyama, Ko-ichiro; Ishiwatari, Masaki; Nishizawa, Seiya; Takahashi, Yoshiyuki O.; Hayashi, Yoshi-Yuki

2017-10-01

Cloud convection of a CO2 atmosphere where the major constituent condenses is numerically investigated under a setup idealizing a possible warm atmosphere of early Mars, utilizing a two-dimensional cloud-resolving model forced by a fixed cooling profile as a substitute for a radiative process. The authors compare two cases with different critical saturation ratios as condensation criteria and also examine sensitivity to number mixing ratio of condensed particles given externally.When supersaturation is not necessary for condensation, the entire horizontal domain above the condensation level is continuously covered by clouds irrespective of number mixing ratio of condensed particles. Horizontal-mean cloud mass density decreases exponentially with height. The circulations below and above the condensation level are dominated by dry cellular convection and buoyancy waves, respectively.When 1.35 is adopted as the critical saturation ratio, clouds appear exclusively as intense, short-lived, quasi-periodic events. Clouds start just above the condensation level and develop upward, but intense updrafts exist only around the cloud top; they do not extend to the bottom of the condensation layer. The cloud layer is rapidly warmed by latent heat during the cloud events, and then the layer is slowly cooled by the specified thermal forcing, and supersaturation gradually develops leading to the next cloud event. The periodic appearance of cloud events does not occur when number mixing ratio of condensed particles is large.

Drought, flood and rainfall analysis under climate change in Crete, Greece

NASA Astrophysics Data System (ADS)

Tapoglou, Evdokia; Vozinaki, Anthi-Eirini; Tsanis, Ioannis; Nerantzaki, Sofia; Nikolaidis, Nikolaos

2017-04-01

In this study an analysis on the drought frequency and magnitude under climate change in Crete, Greece is performed. The analysis was performed for the time period from 1983-2100, divided into three sub-periods (1983-1999, 2000-2049 and 2050-2099) for inter-comparison. Two climate models were studied MPI-ESM-LR-r1-CSC-REMO and EC-EARTH-r12-SMHI-RCA4, following three possible representative concentration pathways (+2.6, +4.5 and +8.5 W/m2). In order to perform the analysis the results of a SWAT simulation which covered the entity of Crete using 352 subbasins, was used. Drought events are recognized by using the Standardized Precipitation Index (SPI) to identify the meteorological drought events and Standardized Runoff Index (SRI) for hydrological droughts. SPI and SRI drought indices, were used in order to identify the number of drought events for each climate model and scenario. In all cases, an increase in both severity and number of drought events was calculated for the future periods, compared to the baseline period 1983-1999. This increase was smaller for the +2.6 W/m2 scenario and largest for the +8.5 W/m2. The magnitude of events with 10 and 100 years return period was calculated for the subbasins of Crete and the most vulnerable were identified, both in terms of severity and the change throughout the years in index magnitude. Next a flood frequency analysis was performed for the entity of Crete Island in order to calculate the magnitude of events with 10 and 100 years return period. In order to perform the flood frequency analysis, the results of the SWAT simulation in terms of runoff in each subbasin are used. By calculating the magnitude of flood events with 10 and 100 years return period and the change in the magnitude throughout the time periods the most vulnerable subbasins are identified. The same frequency analysis was performed for the precipitation at each subbasin, and the magnitude of extreme precipitation events with 10 and 100 years return period was calculated. In this case the most significant changes appeared in Chania prefecture, having a 25-50% increase in extreme precipitation magnitude for the 10 years and the 100 years return period until the end of the third study period. Drought and flood frequency analysis can be proved a valuable tool in water management and infrastructure projects planning providing an integrated analysis for extreme event magnitude anticipation in Crete. The research reported in this paper was fully supported by the Project "Innovative solutions to climate change adaptation and governance in the water management of the Region of Crete - AQUAMAN" funded within the framework of the EEA Financial Mechanism 2009-2014.

Credible occurrence probabilities for extreme geophysical events: earthquakes, volcanic eruptions, magnetic storms

USGS Publications Warehouse

Love, Jeffrey J.

2012-01-01

Statistical analysis is made of rare, extreme geophysical events recorded in historical data -- counting the number of events $k$ with sizes that exceed chosen thresholds during specific durations of time $\\tau$. Under transformations that stabilize data and model-parameter variances, the most likely Poisson-event occurrence rate, $k/\\tau$, applies for frequentist inference and, also, for Bayesian inference with a Jeffreys prior that ensures posterior invariance under changes of variables. Frequentist confidence intervals and Bayesian (Jeffreys) credibility intervals are approximately the same and easy to calculate: $(1/\\tau)[(\\sqrt{k} - z/2)^{2},(\\sqrt{k} + z/2)^{2}]$, where $z$ is a parameter that specifies the width, $z=1$ ($z=2$) corresponding to $1\\sigma$, $68.3\\%$ ($2\\sigma$, $95.4\\%$). If only a few events have been observed, as is usually the case for extreme events, then these "error-bar" intervals might be considered to be relatively wide. From historical records, we estimate most likely long-term occurrence rates, 10-yr occurrence probabilities, and intervals of frequentist confidence and Bayesian credibility for large earthquakes, explosive volcanic eruptions, and magnetic storms.

Extreme event statistics in a drifting Markov chain

NASA Astrophysics Data System (ADS)

Kindermann, Farina; Hohmann, Michael; Lausch, Tobias; Mayer, Daniel; Schmidt, Felix; Widera, Artur

2017-07-01

We analyze extreme event statistics of experimentally realized Markov chains with various drifts. Our Markov chains are individual trajectories of a single atom diffusing in a one-dimensional periodic potential. Based on more than 500 individual atomic traces we verify the applicability of the Sparre Andersen theorem to our system despite the presence of a drift. We present detailed analysis of four different rare-event statistics for our system: the distributions of extreme values, of record values, of extreme value occurrence in the chain, and of the number of records in the chain. We observe that, for our data, the shape of the extreme event distributions is dominated by the underlying exponential distance distribution extracted from the atomic traces. Furthermore, we find that even small drifts influence the statistics of extreme events and record values, which is supported by numerical simulations, and we identify cases in which the drift can be determined without information about the underlying random variable distributions. Our results facilitate the use of extreme event statistics as a signal for small drifts in correlated trajectories.

Optimizing SIEM Throughput on the Cloud Using Parallelization.

PubMed

Alam, Masoom; Ihsan, Asif; Khan, Muazzam A; Javaid, Qaisar; Khan, Abid; Manzoor, Jawad; Akhundzada, Adnan; Khan, Muhammad Khurram; Farooq, Sajid

2016-01-01

Processing large amounts of data in real time for identifying security issues pose several performance challenges, especially when hardware infrastructure is limited. Managed Security Service Providers (MSSP), mostly hosting their applications on the Cloud, receive events at a very high rate that varies from a few hundred to a couple of thousand events per second (EPS). It is critical to process this data efficiently, so that attacks could be identified quickly and necessary response could be initiated. This paper evaluates the performance of a security framework OSTROM built on the Esper complex event processing (CEP) engine under a parallel and non-parallel computational framework. We explain three architectures under which Esper can be used to process events. We investigated the effect on throughput, memory and CPU usage in each configuration setting. The results indicate that the performance of the engine is limited by the number of events coming in rather than the queries being processed. The architecture where 1/4th of the total events are submitted to each instance and all the queries are processed by all the units shows best results in terms of throughput, memory and CPU usage.

Colleges Under Pressure: Budgeting, Presidential Competence, and Faculty Uncertainty.

ERIC Educational Resources Information Center

Neumann, Anna

A comparative case study examining selected aspects of internal college leadership during financially troubled times is discussed. Continuous negotiation between university presidents and faculty members is explained. Presentation of the budget to the college community is examined, noting how the president may use the event to define hard times…

Stress, Coping, and Internet Use of College Students

ERIC Educational Resources Information Center

Deatherage, Scott; Servaty-Seib, Heather L.; Aksoz, Idil

2014-01-01

College students experience stressful life events and little research exists on the role the Internet may play in students' coping. Objective: The purpose of the present study was to examine associations among perceived stress, time spent on the Internet, underlying motives for utilizing the Internet, problematic Internet use, and traditional…

Comparing Nitrous Oxide Emissions from Three Residential Landscapes under Different Management Schemes Following Natural Rainfall Events

EPA Science Inventory

Cultural lawn management practices that produce aesthetically appealing landscapes may also create environmental conditions that stimulate soil nitrous oxide (N2O) emissions. The purpose of this study is to investigate the effects of lawn management practices on N2O fluxes from ...

Analysis of U.S. Propane Markets Winter 1996-97, An

EIA Publications

1997-01-01

This study constitutes an examination of propane supply, demand, and price developments and trends. The Energy Information Administration's approach focused on identifying the underlying reasons for the tight supply/demand balance in the fall of 1996, and on examining the potential for a recurrence of these events next year.

The Tactile Continuity Illusion

ERIC Educational Resources Information Center

Kitagawa, Norimichi; Igarashi, Yuka; Kashino, Makio

2009-01-01

We can perceive the continuity of an object or event by integrating spatially/temporally discrete sensory inputs. The mechanism underlying this perception of continuity has intrigued many researchers and has been well documented in both the visual and auditory modalities. The present study shows for the first time to our knowledge that an illusion…

Optimizing preplant irrigation for maize under limited water in the high plains

USDA-ARS?s Scientific Manuscript database

Due to inadequate irrigation capacity, some farmers in the United States High Plains apply preplant irrigation to buffer the crop between irrigation events during the cropping season. The purpose of the study was to determine preplant irrigation amount and irrigation capacity combinations that optim...

Are We Alone in the Universe?

ERIC Educational Resources Information Center

Waring, Scott M.; Herlihy, Christine

2015-01-01

Primary sources, as defined by the Library of Congress, are the "raw materials of history--original documents and objects which were created at the time under study" (Library of Congress, 2014, p. 1). Primary sources differ from secondary sources, which interpret events without the benefit of firsthand experience. While often employed in…

A classification of event sequences in the influence network

NASA Astrophysics Data System (ADS)

Walsh, James Lyons; Knuth, Kevin H.

2017-06-01

We build on the classification in [1] of event sequences in the influence network as respecting collinearity or not, so as to determine in future work what phenomena arise in each case. Collinearity enables each observer to uniquely associate each particle event of influencing with one of the observer's own events, even in the case of events of influencing the other observer. We further classify events as to whether they are spacetime events that obey in the fine-grained case the coarse-grained conditions of [2], finding that Newton's First and Second Laws of motion are obeyed at spacetime events. A proof of Newton's Third Law under particular circumstances is also presented.

Time-Constrained Functional Connectivity Analysis of Cortical Networks Underlying Phonological Decoding in Typically Developing School-Aged Children: A Magnetoencephalography Study

ERIC Educational Resources Information Center

Simos, Panagiotis G.; Rezaie, Roozbeh; Fletcher, Jack M.; Papanicolaou, Andrew C.

2013-01-01

The study investigated functional associations between left hemisphere occipitotemporal, temporoparietal, and inferior frontal regions during oral pseudoword reading in 58 school-aged children with typical reading skills (aged 10.4 [plus or minus] 1.6, range 7.5-12.5 years). Event-related neuromagnetic data were used to compute source-current…

How the Timing and Quality of Early Experiences Influence the Development of Brain Architecture

ERIC Educational Resources Information Center

Fox, Sharon E.; Levitt, Pat; Nelson, Charles A., III.

2010-01-01

Early life events can exert a powerful influence on both the pattern of brain architecture and behavioral development. In this study a conceptual framework is provided for considering how the structure of early experience gets "under the skin." The study begins with a description of the genetic framework that lays the foundation for brain…

A novel high performance ESD power clamp circuit with a small area

NASA Astrophysics Data System (ADS)

Zhaonian, Yang; Hongxia, Liu; Li, Li; Qingqing, Zhuo

2012-09-01

A MOSFET-based electrostatic discharge (ESD) power clamp circuit with only a 10 ns RC time constant for a 0.18-μm process is proposed. A diode-connected NMOSFET is used to maintain a long delay time and save area. The special structure overcomes other shortcomings in this clamp circuit. Under fast power-up events, the gate voltage of the clamp MOSFET does not rise as quickly as under ESD events, the special structure can keep the clamp MOSFET thoroughly off. Under a falsely triggered event, the special structure can turn off the clamp MOSFET in a short time. The clamp circuit can also reject the power supply noise effectively. Simulation results show that the clamp circuit avoids fast false triggering events such as a 30 ns/1.8 V power-up, maintains a 1.2 μs delay time and a 2.14 μs turn-off time, and reduces to about 70% of the RC time constant. It is believed that the proposed clamp circuit can be widely used in high-speed integrated circuits.

A new index for identifying socioeconomic drought events under climate change over the East River basin in China

NASA Astrophysics Data System (ADS)

Shi, H.; Chen, J.; Wang, K.; Niu, J.

2017-12-01

Drought, which means severe water deficiencies, is a complex natural hazard that may have destructive damages on societal properties and lives. Generally, socioeconomic drought occurs when the water resources systems cannot meet the water demands due to a weather-related shortfall in water supply to societies. This paper aims to propose a new index (i.e., socioeconomic drought index (SEDI)) for identifying socioeconomic drought events on different levels (i.e., slight, moderate, severe and extreme) under climate change through considering the gap between water supply and demand. First, the minimum in-stream water requirement (MWR) is determined through comprehensively considering the requirements of water quality, ecology, navigation and water supply. Second, according to the monthly water deficit calculated as the monthly streamflow data minus the MWR, drought month can be identified. Third, according to the cumulative water deficit derived from the monthly water deficit, drought duration (i.e., the number of continuous drought months) can be detected. Fourth, the SEDI of each socioeconomic drought event can be calculated through integrating the impacts of the cumulative water deficit and drought duration. The study area is the East River basin in South China, and the impact of a multi-year reservoir (i.e., the Xinfengjiang Reservoir) on drought is also analyzed. For historical and future drought analysis, it is concluded that the proposed SEDI is feasible to identify socioeconomic drought events. The results show that a number of socioeconomic drought events (including some extreme ones) may occur during 2020-2099, and the appropriate reservoir operation can significantly ease such situation.

Transformation of soil organics under extreme climate events: a project description

NASA Astrophysics Data System (ADS)

Blagodatskaya, Evgenia

2017-04-01

Recent climate scenarios predict not only continued global warming but also an increased frequency and intensity of extreme climatic events such as strong changes in temperature and precipitation with unusual regional dynamics. Weather anomalies at European territory of Russia are currently revealed as long-term drought and strong showers in summer and as an increased frequency of soil freezing-thawing cycles. Climate extremes totally change biogeochemical processes and elements cycling both at the ecosystem level and at the level of soil profile mainly affecting soil biota. Misbalance in these processes can cause a reduction of soil carbon stock and an increase of greenhouse gases emission. Our project aims to reveal the transformation mechanisms of soil organic matter caused by extreme weather events taking into consideration the role of biotic-abiotic interactions in regulation of formation, maintenance and turnover of soil carbon stock. Our research strategy is based on the novel concept considering extreme climatic events (showers after long-term droughts, soil flooding, freezing-thawing) as abiotic factors initiating a microbial succession. Study on stoichiometric flexibility of plants under climate extremes as well as on resulting response of soil heterotrophs on stoichiometric changes in substrate will be used for experimental prove and further development of the theory of ecological stoichiometry. The results enable us to reveal the mechanisms of biotic - abiotic interactions responsible for the balance between mobilization and stabilization of soil organic matter. Identified mechanisms will form the basis of an ecosystem model enabled to predict the effects of extreme climatic events on biogenic carbon cycle in the biosphere.

Extreme climate events counteract the effects of climate and land-use changes in Alpine treelines

PubMed Central

Barros, Ceres; Guéguen, Maya; Douzet, Rolland; Carboni, Marta; Boulangeat, Isabelle; Zimmermann, Niklaus E.; Münkemüller, Tamara; Thuiller, Wilfried

2017-01-01

Summary 1. Climate change and extreme events, such as drought, threaten ecosystems worldwide and in particular mountain ecosystems, where species often live at their environmental tolerance limits. In the European Alps, plant communities are also influenced by land-use abandonment leading to woody encroachment of subalpine and alpine grasslands. 2. In this study, we explored how the forest–grassland ecotone of Alpine treelines will respond to gradual climate warming, drought events and land-use change in terms of forest expansion rates, taxonomic diversity and functional composition. We used a previously validated dynamic vegetation model, FATE-HD, parameterised for plant communities in the Ecrins National Park in the French Alps. 3. Our results showed that intense drought counteracted the forest expansion at higher elevations driven by land-use abandonment and climate change, especially when combined with high drought frequency (occurring every 2 or less than 2 years). 4. Furthermore, intense and frequent drought accelerated the rates of taxonomic change and resulted in overall higher taxonomic spatial heterogeneity of the ecotone than would be expected under gradual climate and land-use changes only. 5. Synthesis and applications. The results from our model show that intense and frequent drought counteracts forest expansion driven by climate and land-use changes in the forest–grassland ecotone of Alpine treelines. We argue that land-use planning must consider the effects of extreme events, such as drought, as well as climate and land-use changes, since extreme events might interfere with trends predicted under gradual climate warming and agricultural abandonment. PMID:28670002

The promise of disease gene discovery in South Asia

PubMed Central

Nakatsuka, Nathan; Moorjani, Priya; Rai, Niraj; Sarkar, Biswanath; Tandon, Arti; Patterson, Nick; Bhavani, Gandham SriLakshmi; Girisha, Katta Mohan; Mustak, Mohammed S; Srinivasan, Sudha; Kaushik, Amit; Vahab, Saadi Abdul; Jagadeesh, Sujatha M.; Satyamoorthy, Kapaettu; Singh, Lalji; Reich, David; Thangaraj, Kumarasamy

2017-01-01

The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population, but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identify 81 unique groups, of which 14 have estimated census sizes of more than a million, that descend from founder events more extreme than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due to founder events. We identify multiple examples of recessive diseases in South Asia that are the result of such founder events. This study highlights an under-appreciated opportunity for reducing disease burden among South Asians through the discovery of and testing for recessive disease genes. PMID:28714977

Facial Cosmetics Exert a Greater Influence on Processing of the Mouth Relative to the Eyes: Evidence from the N170 Event-Related Potential Component.

PubMed

Tanaka, Hideaki

2016-01-01

Cosmetic makeup significantly influences facial perception. Because faces consist of similar physical structures, cosmetic makeup is typically used to highlight individual features, particularly those of the eyes (i.e., eye shadow) and mouth (i.e., lipstick). Though event-related potentials have been utilized to study various aspects of facial processing, the influence of cosmetics on specific ERP components remains unclear. The present study aimed to investigate the relationship between the application of cosmetic makeup and the amplitudes of the P1 and N170 event-related potential components during facial perception tasks. Moreover, the influence of visual perception on N170 amplitude, was evaluated under three makeup conditions: Eye Shadow, Lipstick, and No Makeup. Electroencephalography was used to monitor 17 participants who were exposed to visual stimuli under each these three makeup conditions. The results of the present study subsequently demonstrated that the Lipstick condition elicited a significantly greater N170 amplitude than the No Makeup condition, while P1 amplitude was unaffected by any of the conditions. Such findings indicate that the application of cosmetic makeup alters general facial perception but exerts no influence on the perception of low-level visual features. Collectively, these results support the notion that the application of makeup induces subtle alterations in the processing of facial stimuli, with a particular effect on the processing of specific facial components (i.e., the mouth), as reflected by changes in N170 amplitude.

Facial Cosmetics Exert a Greater Influence on Processing of the Mouth Relative to the Eyes: Evidence from the N170 Event-Related Potential Component

PubMed Central

Tanaka, Hideaki

2016-01-01

Cosmetic makeup significantly influences facial perception. Because faces consist of similar physical structures, cosmetic makeup is typically used to highlight individual features, particularly those of the eyes (i.e., eye shadow) and mouth (i.e., lipstick). Though event-related potentials have been utilized to study various aspects of facial processing, the influence of cosmetics on specific ERP components remains unclear. The present study aimed to investigate the relationship between the application of cosmetic makeup and the amplitudes of the P1 and N170 event-related potential components during facial perception tasks. Moreover, the influence of visual perception on N170 amplitude, was evaluated under three makeup conditions: Eye Shadow, Lipstick, and No Makeup. Electroencephalography was used to monitor 17 participants who were exposed to visual stimuli under each these three makeup conditions. The results of the present study subsequently demonstrated that the Lipstick condition elicited a significantly greater N170 amplitude than the No Makeup condition, while P1 amplitude was unaffected by any of the conditions. Such findings indicate that the application of cosmetic makeup alters general facial perception but exerts no influence on the perception of low-level visual features. Collectively, these results support the notion that the application of makeup induces subtle alterations in the processing of facial stimuli, with a particular effect on the processing of specific facial components (i.e., the mouth), as reflected by changes in N170 amplitude. PMID:27656161

Inhibition of VEGF Signaling Reduces Diabetes-Exacerbated Brain Swelling, but Not Infarct Size, in Large Cerebral Infarction in Mice.

PubMed

Kim, Eunhee; Yang, Jiwon; Park, Keun Woo; Cho, Sunghee

2017-12-30

In light of repeated translational failures with preclinical neuroprotection-based strategies, this preclinical study reevaluates brain swelling as an important pathological event in diabetic stroke and investigates underlying mechanism of the comorbidity-enhanced brain edema formation. Type 2 (mild), type 1 (moderate), and mixed type 1/2 (severe) diabetic mice were subjected to transient focal ischemia. Infarct volume, brain swelling, and IgG extravasation were assessed at 3 days post-stroke. Expression of vascular endothelial growth factor (VEGF)-A, endothelial-specific molecule-1 (Esm1), and the VEGF receptor 2 (VEGFR2) was determined in the ischemic brain. Additionally, SU5416, a VEGFR2 inhibitor, was treated in the type 1/2 diabetic mice, and stroke outcomes were determined. All diabetic groups displayed bigger infarct volume and brain swelling compared to nondiabetic mice, and the increased swelling was disproportionately larger relative to infarct enlargement. Diabetic conditions significantly increased VEGF-A, Esm1, and VEGFR2 expressions in the ischemic brain compared to nondiabetic mice. Notably, in diabetic mice, VEGFR2 mRNA levels were positively correlated with brain swelling, but not with infarct volume. Treatment with SU5416 in diabetic mice significantly reduced brain swelling. The study shows that brain swelling is a predominant pathological event in diabetic stroke and that an underlying event for diabetes-enhanced brain swelling includes the activation of VEGF signaling. This study suggests consideration of stroke therapies aiming at primarily reducing brain swelling for subjects with diabetes.

Impacts of short-term heatwaves on sun-induced chlorophyll fluorescence(SiF) in temperate tree species

NASA Astrophysics Data System (ADS)

Wang, F.; Gu, L.; Guha, A.; Han, J.; Warren, J.

2017-12-01

The current projections for global climate change forecast an increase in the intensity and frequency of extreme climatic events, such as droughts and short-term heat waves. Understanding the effects of short-term heat wave on photosynthesis process is of critical importance to predict global impacts of extreme weather event on vegetation. The diurnal and seasonal characteristics of SIF emitted from natural vegetation, e.g., forest and crop, have been studied at the ecosystem-scale, regional-scale and global-scale. However, the detailed response of SIF from different plant species under extremely weather event, especially short-term heat wave, have not been reported. The purpose of this study was to study the response of solar-induced chlorophyll fluorescence, gas exchange and continuous fluorescence at leaf scale for different temperate tree species. The short-term heatwave experiment was conducted using plant growth chamber (CMP6050, Conviron Inc., Canada). We developed an advanced spectral fitting method to obtain the plant SIF in the plant growth chamber. We compared SIF variation among different wavelength and chlorophyll difference among four temperate tree species. The diurnal variation of SIF signals at leaf-scales for temperate tree species are different under heat stress. The SIF response at leaf-scales and their difference for four temperate tree species are different during a cycle of short-term heatwave stress. We infer that SIF be used as a measure of heat tolerance for temperate tree species.

An event-related brain potential study of visual selective attention to conjunctions of color and shape.

PubMed

Smid, H G; Jakob, A; Heinze, H J

1999-03-01

What cognitive processes underlie event-related brain potential (ERP) effects related to visual multidimensional selective attention and how are these processes organized? We recorded ERPs when participants attended to one conjunction of color, global shape and local shape and ignored other conjunctions of these attributes in three discriminability conditions. Attending to color and shape produced three ERP effects: frontal selection positivity (FSP), central negativity (N2b), and posterior selection negativity (SN). The results suggested that the processes underlying SN and N2b perform independent within-dimension selections, whereas the process underlying the FSP performs hierarchical between-dimension selections. At posterior electrodes, manipulation of discriminability changed the ERPs to the relevant but not to the irrelevant stimuli, suggesting that the SN does not concern the selection process itself but rather a cognitive process initiated after selection is finished. Other findings suggested that selection of multiple visual attributes occurs in parallel.

[Influence of early childhood stress exposure and traumatic life events on pain perception].

PubMed

Tesarz, J; Gerhardt, A; Eich, W

2018-06-05

Adult pain perception is influenced substantially by interactions between mind, body, and social environment during early life. Early stress exposure and traumatic life events induce powerful psychophysical stress reactions that exert multiple neurofunctional processes. This has significant implications for pain perception and pain processing. As part of this review, the complex relationships between traumatic stress experiences and associated psychobiological mechanisms of chronic pain will be discussed. Based on selected studies, psychophysiological findings are presented and possible underlying mechanisms are discussed. The article concludes with a discussion of potential implications for treatment.

The Study of the Relationship between Probabilistic Design and Axiomatic Design Methodology. Volume 3

NASA Technical Reports Server (NTRS)

Onwubiko, Chin-Yere; Onyebueke, Landon

1996-01-01

Structural failure is rarely a "sudden death" type of event, such sudden failures may occur only under abnormal loadings like bomb or gas explosions and very strong earthquakes. In most cases, structures fail due to damage accumulated under normal loadings such as wind loads, dead and live loads. The consequence of cumulative damage will affect the reliability of surviving components and finally causes collapse of the system. The cumulative damage effects on system reliability under time-invariant loadings are of practical interest in structural design and therefore will be investigated in this study. The scope of this study is, however, restricted to the consideration of damage accumulation as the increase in the number of failed components due to the violation of their strength limits.

Regional variations in definitions and rates of hypoglycaemia: findings from the global HAT observational study of 27 585 people with Type 1 and insulin-treated Type 2 diabetes mellitus.

PubMed

Khunti, K; Cigrovski Berković, M; Ludvik, B; Moberg, E; Barner Lekdorf, J; Gydesen, H; Pedersen-Bjergaard, U

2018-05-05

To determine participant knowledge and reporting of hypoglycaemia in the non-interventional Hypoglycaemia Assessment Tool (HAT) study. HAT was conducted in 24 countries over a 6-month retrospective/4-week prospective period in 27 585 adults with Type 1 or insulin-treated Type 2 diabetes mellitus. Participants recorded whether hypoglycaemia was based on blood glucose levels, symptoms or both. Hypoglycaemia rates were consistently higher in the prospective compared with the retrospective period. Most respondents (96.8% Type 1 diabetes; 85.6% Type 2 diabetes) knew the American Diabetes Association/European Association for the Study of Diabetes hypoglycaemia definition, but there were regional differences in the use of blood glucose measurements and/or symptoms to define events. Confirmed symptomatic hypoglycaemia rates were highest in Northern Europe/Canada for Type 1 diabetes (63.9 events/year) and in Eastern Europe for Type 2 diabetes (19.4 events/year), and lowest in South East Asia (Type 1 diabetes: 6.0 events/year; Type 2 diabetes: 3.2 events/year). Unconfirmed symptomatic hypoglycaemia rates were highest in Eastern Europe for Type 1 diabetes (5.6 events/year) and South East Asia for Type 2 diabetes (4.7 events/year), and lowest for both in Russia (Type 1 diabetes: 2.1 events/year; Type 2 diabetes: 0.4 events/year). Participants in Latin America reported the highest rates of severe hypoglycaemia (Type 1 diabetes: 10.8 events/year; Type 2 diabetes 3.7 events/year) and severe hypoglycaemia requiring hospitalization (Type 1 diabetes: 0.56 events/year; Type 2 diabetes: 0.44 events/year). The lowest rates of severe hypoglycaemia were reported in South East Asia (Type 1 diabetes: 2.0 events/year) and Northern Europe/Canada (Type 2 diabetes: 1.3 events/year), and the lowest rates of severe hypoglycaemia requiring hospitalization were in Russia (Type 1 diabetes: 0.15 events/year; Type 2 diabetes: 0.09 events/year). The blood glucose cut-off used to define hypoglycaemia varied between regions (Type 1 diabetes: 3.1-3.6 mmol/l; Type 2 diabetes: 3.5-3.8 mmol/l). Under-reporting of hypoglycaemia rates in retrospective recall and regional variations in participant definitions of hypoglycaemia may contribute to the global differences in reported rates. Discrepancies between participant definitions and guidelines may highlight a need to redefine hypoglycaemia criteria. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

An investigation into the two-stage meta-analytic copula modelling approach for evaluating time-to-event surrogate endpoints which comprise of one or more events of interest.

PubMed

Dimier, Natalie; Todd, Susan

2017-09-01

Clinical trials of experimental treatments must be designed with primary endpoints that directly measure clinical benefit for patients. In many disease areas, the recognised gold standard primary endpoint can take many years to mature, leading to challenges in the conduct and quality of clinical studies. There is increasing interest in using shorter-term surrogate endpoints as substitutes for costly long-term clinical trial endpoints; such surrogates need to be selected according to biological plausibility, as well as the ability to reliably predict the unobserved treatment effect on the long-term endpoint. A number of statistical methods to evaluate this prediction have been proposed; this paper uses a simulation study to explore one such method in the context of time-to-event surrogates for a time-to-event true endpoint. This two-stage meta-analytic copula method has been extensively studied for time-to-event surrogate endpoints with one event of interest, but thus far has not been explored for the assessment of surrogates which have multiple events of interest, such as those incorporating information directly from the true clinical endpoint. We assess the sensitivity of the method to various factors including strength of association between endpoints, the quantity of data available, and the effect of censoring. In particular, we consider scenarios where there exist very little data on which to assess surrogacy. Results show that the two-stage meta-analytic copula method performs well under certain circumstances and could be considered useful in practice, but demonstrates limitations that may prevent universal use. Copyright © 2017 John Wiley & Sons, Ltd.

Exercise-induced hypertension, cardiovascular events, and mortality in patients undergoing exercise stress testing: a systematic review and meta-analysis.

PubMed

Schultz, Martin G; Otahal, Petr; Cleland, Verity J; Blizzard, Leigh; Marwick, Thomas H; Sharman, James E

2013-03-01

The prognostic relevance of a hypertensive response to exercise (HRE) is ill-defined in individuals undergoing exercise stress testing. The study described here was intended to provide a systematic review and meta-analysis of published literature to determine the value of exercise-related blood pressure (BP) (independent of office BP) for predicting cardiovascular (CV) events and mortality. Online databases were searched for published longitudinal studies reporting exercise-related BP and CV events and mortality rates. We identified for review 12 longitudinal studies with a total of 46,314 individuals without significant coronary artery disease, with total CV event and mortality rates recorded over a mean follow-up of 15.2±4.0 years. After adjustment for age, office BP, and CV risk factors, an HRE at moderate exercise intensity carried a 36% greater rate of CV events and mortality (95% CI, 1.02-1.83, P = 0.039) than that of subjects without an HRE. Additionally, each 10mm Hg increase in systolic BP during exercise at moderate intensity was accompanied by a 4% increase in CV events and mortality, independent of office BP, age, or CV risk factors (95% CI, 1.01-1.07, P = 0.02). Systolic BP at maximal workload was not significantly associated with the outcome of an increased rate of CV, whether analyzed as a categorical (HR=1.49, 95% CI, 0.90-2.46, P = 0.12) or a continuous (HR=1.01, 95% CI, 0.98-1.04, P = 0.53) variable. An HRE at moderate exercise intensity during exercise stress testing is an independent risk factor for CV events and mortality. This highlights the need to determine underlying pathophysiological mechanisms of exercise-induced hypertension.

Are schools and alcohol a good mix? A qualitative study of school principals' experiences of adults' alcohol use in Australian secondary schools.

PubMed

Ward, Bernadette M; Buykx, Penny; Munro, Geoffrey; Wiggers, John

2016-08-01

Parents, schools and the broader community influence children's socialisation to alcohol. In Australia, the UK and the USA, there have been media reports of adults consuming alcohol at family-focused school events such as fairs and graduations. The aim of this qualitative study was to describe school principals' experiences of adults' use of alcohol at school events, when children are present. A qualitative study was undertaken. Publicly available lists were used to invite 60 principals from government and Catholic secondary schools in Victoria, Australia. In-depth interviews were conducted and analysed thematically and reported using the Consolidated Criteria for Reporting Qualitative Research guidelines. 14 principals (5 female, 9 male) participated. Most (10) of the participating principals reported adults' use of alcohol at events when students were present. Regarding these events, most principals reported concerns regarding potential harms and responsibility for decision-making about alcohol availability in schools. Some (4) principals believed alcohol should not be present at such events and this was their practice. Half of the participating schools had recently made changes to reduce the availability or management of alcohol at school functions. The findings confirm the common use of alcohol by adults at school events, the challenges this poses for school principals and suggests consideration needs to be given to identifying strategies for supporting schools and school principals in decision-making regarding the conduct of such events. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Unconscious symmetrical inferences: A role of consciousness in event integration.

PubMed

Alonso, Diego; Fuentes, Luis J; Hommel, Bernhard

2006-06-01

Explicit and implicit learning have been attributed to different learning processes that create different types of knowledge structures. Consistent with that claim, our study provides evidence that people integrate stimulus events differently when consciously aware versus unaware of the relationship between the events. In a first, acquisition phase participants sorted words into two categories (A and B), which were fully predicted by task-irrelevant primes-the labels of two other, semantically unrelated categories (C and D). In a second, test phase participants performed a lexical decision task, in which all word stimuli stemmed from the previous prime categories (C and D) and the (now nonpredictive) primes were the labels of the previous target categories (A and B). Reliable priming effects in the second phase demonstrated that bidirectional associations between the respective categories had been formed in the acquisition phase (A<-->C and B<-->D), but these effects were found only in participants that were unaware of the relationship between the categories! We suggest that unconscious, implicit learning of event relationships results in the rather unsophisticated integration (i.e., bidirectional association) of the underlying event representations, whereas explicit learning takes the meaning of the order of the events into account, and thus creates unidirectional associations.