understanding common psychocutaneous: Topics by Science.gov

Sample records for understanding common psychocutaneous

Psychodermatology: A Guide to Understanding Common Psychocutaneous Disorders

PubMed Central

Jafferany, Mohammad

2007-01-01

Objective: This review focuses on classification and description of and current treatment recommendations for psychocutaneous disorders. Medication side effects of both psychotropic and dermatologic drugs are also considered. Data Sources: A search of the literature from 1951 to 2004 was performed using the MEDLINE search engine. English-language articles were identified using the following search terms: skin and psyche, psychiatry and dermatology, mind and skin, psychocutaneous, and stress and skin. Data Synthesis: The psychotropic agents most frequently used in patients with psychocutaneous disorders are those that target anxiety, depression, and psychosis. Psychiatric side effects of dermatologic drugs can be significant but can occur less frequently than the cutaneous side effects of psychiatric medications. In a majority of patients presenting to dermatologists, effective management of skin conditions requires consideration of associated psychosocial factors. For some dermatologic conditions, there are specific demographic and personality features that commonly associate with disease onset or exacerbation. Conclusions: More than just a cosmetic disfigurement, dermatologic disorders are associated with a variety of psychopathologic problems that can affect the patient, his or her family, and society together. Increased understanding of biopsychosocial approaches and liaison among primary care physicians, psychiatrists, and dermatologists could be very useful and highly beneficial. PMID:17632653
Pyschodermatology: a trip through history*

PubMed Central

França, Katlein; Chacon, Anna; Ledon, Jennifer; Savas, Jessica; Nouri, Keyvan

2013-01-01

The interaction between the mind and diseases of the skin has been the study focus for many researchers worldwide. The field of Psychodermatology, or Psychocutaneous Medicine, is the result of the merging of two major medical specialties, psychiatry and dermatology. Although the history of Psychodermatology is rather old and interesting, the field has only recently gained popularity. Since ancient times, philosophers, surgeons, dermatologists and psychiatrists have reported the presence of psychocutaneous diseases in various scenarios. In this article, the authors describe curious and remarkable facts in the history of Psychodermatology. PMID:24173201
Nonpharmacologic treatments in psychodermatology.

PubMed

Fried, Richard G

2002-01-01

The author believes that psychocutaneous medicine has indeed come of age and is being incorporated into mainstream medical practice. Patients presenting to dermatologists today are more sophisticated and are frequently dissatisfied with traditional medical therapies. They actively seek alternative approaches and adjuncts to standard treatments. In contrast to many other "alternative" (or) "holistic" treatments offered through non-medical venues, dermatologists can assure their patients that controlled studies support the efficacy of psychocutaneous techniques in improving many dermatologic conditions. Psoriasis, rosacea, herpes simplex, body dysmorphic disorder, acne, eczema, urticaria, neurotic excoriations, excoriated acne, trichotillomania, dysesthetic syndromes, and delusions parasitosis are included in this incomplete list. The author believes it is helpful for both the patient and therapist to define concrete and realistic goals for psychocutaneous intervention. Concrete observable or measurable goals can help the patient and clinician gauge therapeutic progress and success. Specifically, goals can include reduction in pruritus (rating severity from 1-10), decreased scratching activity, decreased plaque extent or thickness, decreased number of urticarial plaques, decreased flushing, decreased anxiety, decreased anger, decreased social embarrassment, decreased social withdrawal, and improved sleep. More global goals can include an improved sense of well-being, increased sense of control, and enhanced acceptance of some of the inevitable aspects of a given skin disease. Cure should never be a goal, because most disorders amenable to psychocutaneous techniques are chronic in nature; thus, cure as an endpoint would only lead to disappointment. The author encourages dermatologists to align themselves with what he euphemistically calls "a skin-emotion specialist." The skin-emotion specialist may be a psychiatrist, psychologist, social worker, biofeedback therapist, or other mental health or behavioral specialist. Patients are more likely to accept a referral to a "skin-emotion specialist," because this term destigmatizes psychologic interventions. Incorporating these techniques and specialists into a clinical practice will expand therapeutic horizons and improve the quality of life of many of the patients afflicted with chronic skin disease. A final caveat must be offered about attempting to make prognostic statements regarding the likelihood of therapeutic success. Although all patients can potentially benefit from psychocutaneous interventions, those with severe psychopathology and poor pretreatment functional status are likely to be more difficult to treat and to achieve less optimal outcomes. Patients with personality disorders such as borderline, narcissistic, and schizotypal disorders, and patients with any active psychotic process certainly constitute a more resistant and difficult population with whom therapeutic success is less likely. These patients, however, are often the ones in the greatest subjective distress and certainly can profit from any of the described interventions. Quoting W. Mitchell Sams, Jr., "although the physician is a scientist and clinician, he or she is and must be something more. A doctor is a caretaker of the patient's person--a professional advisor, guiding the patient through some of life's most difficult journeys. Only the clergy share this responsibility with us." This commitment is and must always be the guiding force in the provision of comprehensive and compatient patient care.
Artefactual skin lesions in children and adolescents: review of the literature and two cases of factitious purpura.

PubMed

Ring, Hans Christian; Miller, Iben M; Benfeldt, Eva; Jemec, Gregor B E

2015-01-01

Self harm is a great diagnostic and treatment challenge. In addition, psychocutaneous conditions are rare in the pediatric population and may therefore be misdiagnosed. Dermatitis artefacta is a psychocutaneous syndrome, which is a subgroup of the general spectrum of self-inflicted skin lesions. Dermatitis artefacta encompasses an array of different clinical manifestations, including purpura. Factitious purpura has rarely been reported in children. Case report and review of the literature. We describe two Caucasian patients (9-year-old boy and 10-year-old girl) with striking purpuric lesions diagnosed as factitious purpura. The clinical lesions were similar, but the underlying psychological problems differed significantly (depression and stress). The current state of knowledge of dermatitis artefacta in children and adolescents was reviewed. The presence of purpura in children and adolescents typically causes extensive intervention programs due to the possible serious pathological consequences. The two cases demonstrate a need for a high degree of attention to psychological disturbances, lesional evolution, and distribution once the suspicion is established. © 2014 The International Society of Dermatology.
Folie a deux and delusional disorder by proxy: an atypical presentation.

PubMed

Daulatabad, Deepashree; Sonthalia, Sidharth; Srivastava, Ankur; Bhattacharya, Sambit Nath; Kaul, Subuhi; Moyal, Deepak

2017-08-01

Delusion of parasitosis is a rare condition characterised by an individual harbouring the delusion of being infested with insects or parasites. We report a rare and interesting case of delusion of parasitosis presenting as folie a deux, that is, the delusion is shared by both the parents of an 18-month-old child, with proxy projection of parental delusion on the child. The case highlights the rare concomitant occurrence of two psychocutaneous disorders and emphasizes the importance of early recognition and appropriate intervention to safeguard the well-being of the child. © 2016 The Australasian College of Dermatologists.
A Study of Depression and Quality of Life in Patients of Lichen Planus

PubMed Central

Sawant, Neena S.; Vanjari, Nakul A.; Khopkar, Uday; Adulkar, Satish

2015-01-01

The precise cause of lichen planus is unknown, but the disease seems to be immunologically mediated. It is a psychocutaneous disorder. Due to scarcity of Indian studies in this field, we decided to study in patients of lichen planus the prevalence of depression and quality of life with comparison of the same in both the genders. Patients diagnosed as having lichen planus by consultant dermatologist were enrolled after informed consent and ethics approval. 45 patients were screened, of which 35 who satisfied the criteria were taken up for the study. A semistructured proforma was designed to collect the necessary information with administration of dermatology life quality index and Beck's depression inventory. While 25% were depressed with females being more affected than males, quality of life was impaired in more than 90% patients. Impairment was maximum due to symptoms and illness feelings, disturbed daily activities, or work and time consumption in treatment. There was a strong association between depression and impairment in quality of life in both the genders. This study helps in early identification of psychological problems in lichen planus patients and in planning their future course of management, hence reducing the lack of productivity and improving the prognosis and quality of life. PMID:25802892
Epidermal multinucleated keratinocytes: a histopathologic clue to dermatitis artefacta.

PubMed

Gutierrez, Daniel; Schowalter, Michael K; Piliang, Melissa P; Fernandez, Anthony P

2016-10-01

Dermatitis artefacta is a psycho-cutaneous disorder characterized by self-inflicted cutaneous injuries, often in association with an underlying psychiatric disorder or as a response to external stressors. Cutaneous lesions suggestive of dermatitis artefacta are dependent on the means of injury and thus may be morphologically variable, but typically have geometric shapes, spare hard-to-reach anatomic areas, and are present in variable stages of evolution at any specific time. Although a dermatologist may be suspicious of dermatitis artefacta in a given patient, making a definitive diagnosis is extremely challenging. Patients often clinically evade questioning and deny creating skin lesions, and histopathologic evaluation of lesional biopsies usually reveals non-specific epidermal and dermal changes and inflammation. Thus, identification of clues that lend support to a diagnosis of dermatitis artefacta would be welcomed by both clinicians and pathologists. Here we present a case of dermatitis artefacta with a unique, yet previously reported, histopathological finding of multinucleated keratinocytes within the epidermis. Although probably uncommon and dependent on the etiology of cutaneous injury, we believe this finding is important for dermatopathologists to be aware of as a potential diagnostic clue when evaluating biopsies in patients suspected to have dermatitis artefacta. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
The Call to Critique "Common Sense" Understandings about Boys and Masculinity(ies)

ERIC Educational Resources Information Center

Dalley-Trim, Leanne

2009-01-01

This paper is founded upon the premise that "common sense" understandings about boys persist within schools and, given this continuing circulation of such understandings, advocates the need to critique such conceptualising. It does so on the grounds that such understandings, and the essentialist discursive knowledges informing these, fail to take…
Understanding the Skills in the Common Core State Standards

ERIC Educational Resources Information Center

Blosveren, Kate

2012-01-01

As defined on the Common Core State Standards (CCSS) website, "the Common Core State Standards provide a consistent, clear understanding of what students are expected to learn... reflecting the "knowledge" and "skills" that our young people need for success in college and careers." While the "knowledge" defined within the CCSS is apparent--the…
A model of collaborative agency and common ground.

PubMed

Kuziemsky, Craig E; Cornett, Janet Alexandra

2013-01-01

As more healthcare delivery is provided via collaborative means there is a need to understand how to design information and communication technologies (ICTs) to support collaboration. Existing research has largely focused on individual aspects of ICT usage and not how they can support the coordination of collaborative activities. In order to understand how we can design ICTs to support collaboration we need to understand how agents, technologies, information and processes integrate while providing collaborative care delivery. Co-agency and common ground have both provided insight about the integration of different entities as part of collaboration practices. However there is still a lack of understanding about how to coordinate the integration of agents, processes and technologies to support collaboration. This paper combines co-agency and common ground to develop a model of collaborative agency and specific categories of common ground to facilitate its coordination.
Understanding Expenditure Data.

ERIC Educational Resources Information Center

Dyke, Frances L.

2000-01-01

Stresses the importance of common understandings of cost definitions and data collection in order to create reliable databases with optimal utility for inter-institutional analysis. Examines definitions of common expenditure categories, discusses cost-accumulation rules governing financial reporting, and explains differences between direct costs…
Expanding the MEU(SOC) Joint Task Force Enabler Concept

DTIC Science & Technology

1998-05-28

concept. 2 The influential twentieth-century linguistic philosopher Ludwig Wittgenstein argued that real understanding rests on the precise use...of language and universally agreed upon meanings. Without clarity and common understanding, Wittgenstein observed, we can never really communicate... Wittgenstein anticipated when we don’t share a common understanding of what a term means. The Joint Task Force Enabler is potentially a critical concept, both
Common NICU Equipment

MedlinePlus

... care unit (NICU) > Common NICU equipment Common NICU equipment E-mail to a friend Please fill in ... understand how they can help your baby. What equipment is commonly used in the NICU? Providers use ...
What Should Common Core Assessments Measure?

ERIC Educational Resources Information Center

Chandler, Kayla; Fortune, Nicholas; Lovett, Jennifer N.; Scherrer, Jimmy

2016-01-01

The Common Core State Standards for mathematics promote ideals about learning mathematics by providing specific standards focused on conceptual understanding and incorporating practices in which students must participate to develop conceptual understanding. Thus, how we define learning is pivotal because our current definition isn't aligned with…
Understanding common statistical methods, Part I: descriptive methods, probability, and continuous data.

PubMed

Skinner, Carl G; Patel, Manish M; Thomas, Jerry D; Miller, Michael A

2011-01-01

Statistical methods are pervasive in medical research and general medical literature. Understanding general statistical concepts will enhance our ability to critically appraise the current literature and ultimately improve the delivery of patient care. This article intends to provide an overview of the common statistical methods relevant to medicine.
Early Word Comprehension in Infants: Replication and Extension

PubMed Central

Bergelson, Elika; Swingley, Daniel

2014-01-01

A handful of recent experimental reports have shown that infants of 6 to 9 months know the meanings of some common words. Here, we replicate and extend these findings. With a new set of items, we show that when young infants (age 6-16 months, n=49) are presented with side-by-side video clips depicting various common early words, and one clip is named in a sentence, they look at the named video at above-chance rates. We demonstrate anew that infants understand common words by 6-9 months, and that performance increases substantially around 14 months. The results imply that 6-9 month olds’ failure to understand words not referring to objects (verbs, adjectives, performatives) in a similar prior study is not attributable to the use of dynamic video depictions. Thus, 6-9 month olds’ experience of spoken language includes some understanding of common words for concrete objects, but relatively impoverished comprehension of other words. PMID:26664329
Finding Common Ground Between Earth Scientists and Evangelical Christians

NASA Astrophysics Data System (ADS)

Grant Ludwig, L.

2015-12-01

In recent decades there has been some tension between earth scientists and evangelical Christians in the U.S., and this tension has spilled over into the political arena and policymaking on important issues such as climate change. From my personal and professional experience engaging with both groups, I find there is much common ground for increasing understanding and communicating the societal relevance of earth science. Fruitful discussions can arise from shared values and principles, and common approaches to understanding the world. For example, scientists and Christians are engaged in the pursuit of truth, and they value moral/ethical decision-making based on established principles. Scientists emphasize the benefits of research "for the common good" while Christians emphasize the value of doing "good works". Both groups maintain a longterm perspective: Christians talk about "the eternal" and geologists discuss "deep time". Both groups understand the importance of placing new observations in context of prior understanding: scientists diligently reference "the literature" while Christians quote "chapter and verse". And members of each group engage with each other in "fellowship" or "meetings" to create a sense of community and reinforce shared values. From my perspective, earth scientists can learn to communicate the importance and relevance of science more effectively by engaging with Christians in areas of common ground, rather than by trying to win arguments or debates.
A Reasoning Hardware Platform for Real-Time Common-Sense Inference

PubMed Central

Barba, Jesús; Santofimia, Maria J.; Dondo, Julio; Rincón, Fernando; Sánchez, Francisco; López, Juan Carlos

2012-01-01

Enabling Ambient Intelligence systems to understand the activities that are taking place in a supervised context is a rather complicated task. Moreover, this task cannot be successfully addressed while overlooking the mechanisms (common-sense knowledge and reasoning) that entitle us, as humans beings, to successfully undertake it. This work is based on the premise that Ambient Intelligence systems will be able to understand and react to context events if common-sense capabilities are embodied in them. However, there are some difficulties that need to be resolved before common-sense capabilities can be fully deployed to Ambient Intelligence. This work presents a hardware accelerated implementation of a common-sense knowledge-base system intended to improve response time and efficiency. PMID:23012540
Common Core Implementation Decisions Made by Principals in Elementary Schools

ERIC Educational Resources Information Center

Norman, Alexis Cienfuegos

2016-01-01

The purpose of this study was to understand the decisions elementary principals have made during the Common Core State Standards reform. Specifically, (a) what decisions principals have made to support Common Core implementation, (b) what strategies elementary principals have employed to communicate with stakeholders about Common Core State…
Using Pre-Assessment and In-Class Questions to Change Student Understanding of Molecular Movements †

PubMed Central

Shi, J.; Knight, Jennifer K.; Chun, Hyonho; Guild, Nancy A.; Martin, Jennifer M.

2017-01-01

Understanding how different types of molecules move through cell membranes is a fundamental part of cell biology. To identify and address student misconceptions surrounding molecular movement through cell membranes, we surveyed student understanding on this topic using pre-class questions, in-class clicker questions, and subsequent exam questions in a large introductory biology course. Common misconceptions identified in student responses to the pre-class assessment questions were used to generate distractors for clicker questions. Two-tier diagnostic clicker questions were used to probe incoming common student misconceptions (first tier) and their reasoning (second tier). Two subsequent lectures with assessment clicker questions were used to help students construct a new framework to understand molecular movement through cell membranes. Comparison of pre-assessment and post-assessment (exam) performance showed dramatic improvement in students’ understanding of molecular movement: student answers to exam questions were 74.6% correct with correct reasoning while only 1.3% of the student answers were correct with correct reasoning on the pre-class assessment. Our results show that students’ conceptual understanding of molecular movement through cell membranes progressively increases through discussions of a series of clicker questions and suggest that this clicker-based teaching strategy was highly effective in correcting common student misconceptions on this topic. PMID:28512521

An anthropological exploration of contemporary bioethics: the varieties of common sense.

PubMed

Turner, L

1998-04-01

Patients and physicians can inhabit distinctive social worlds where they are guided by diverse understandings of moral practice. Despite the contemporary presence of multiple moral traditions, religious communities and ethnic backgrounds, two of the major methodological approaches in bioethics, casuistry and principlism, rely upon the notion of a common morality. However, the heterogeneity of ethnic, moral, and religious traditions raises questions concerning the singularity of common sense. Indeed, it might be more appropriate to consider plural traditions of moral reasoning. This poses a considerable challenge for bioethicists because the existence of plural moral traditions can lead to difficulties regarding "closure" in moral reasoning. The topics of truth-telling, informed consent, euthanasia, and brain death and organ transplantation reveal the presence of different understandings of common sense. With regard to these subjects, plural accounts of "common sense" moral reasoning exist.
Children's Understandings of Rurality: Exploring the Interrelationship between Experience and Understanding.

ERIC Educational Resources Information Center

McCormack, Jaleh

2002-01-01

Explores children's material and discursive experiences of rurality in New Zealand and how they contribute to children's understandings of rurality. Highlights common constructions of reality based on experiences of agriculture, nature, and recreation, as well as children's understandings of rurality from discourse with peers and adults. (Contains…
Common Core: Teaching Optimum Topic Exploration (TOTE)

ERIC Educational Resources Information Center

Karge, Belinda Dunnick; Moore, Roxane Kushner

2015-01-01

The Common Core has become a household term and yet many educators do not understand what it means. This article explains the historical perspectives of the Common Core and gives guidance to teachers in application of Teaching Optimum Topic Exploration (TOTE) necessary for full implementation of the Common Core State Standards. An effective…
Experimenting with C2 Applications and Federated Infrastructures for Integrated Full-Spectrum Operational Environments in Support of Collaborative Planning and Interoperable Execution

DTIC Science & Technology

2004-06-01

Situation Understanding) Common Operational Pictures Planning & Decision Support Capabilities Message & Order Processing Common Operational...Pictures Planning & Decision Support Capabilities Message & Order Processing Common Languages & Data Models Modeling & Simulation Domain
Relating spatial perspective taking to the perception of other's affordances: providing a foundation for predicting the future behavior of others

PubMed Central

Creem-Regehr, Sarah H.; Gagnon, Kyle T.; Geuss, Michael N.; Stefanucci, Jeanine K.

2013-01-01

Understanding what another agent can see relates functionally to the understanding of what they can do. We propose that spatial perspective taking and perceiving other's affordances, while two separate spatial processes, together share the common social function of predicting the behavior of others. Perceiving the action capabilities of others allows for a common understanding of how agents may act together. The ability to take another's perspective focuses an understanding of action goals so that more precise understanding of intentions may result. This review presents an analysis of these complementary abilities, both in terms of the frames of reference and the proposed sensorimotor mechanisms involved. Together, we argue for the importance of reconsidering the role of basic spatial processes to explain more complex behaviors. PMID:24068992
Memorandum of Understanding on Long-Term Stewardship at Federal Facilities in the United States

EPA Pesticide Factsheets

The purpose of this Memorandum of Understanding is to provide a common understanding and basis for discussion and coordination between the Environmental Council of the States and relevant federal agencies regarding Long-Term Stewardship.
Probing Student Understanding of Scientific Thinking in the Context of Introductory Astrophysics

ERIC Educational Resources Information Center

Steinberg, Richard N.; Cormier, Sebastien; Fernandez, Adiel

2009-01-01

Common forms of testing of student understanding of science content can be misleading about their understanding of the nature of scientific thinking. Observational astronomy integrated with related ideas of force and motion is a rich context to explore the correlation between student content knowledge and student understanding of the scientific…
Prediction of missing common genes for disease pairs using network based module separation on incomplete human interactome.

PubMed

Akram, Pakeeza; Liao, Li

2017-12-06

Identification of common genes associated with comorbid diseases can be critical in understanding their pathobiological mechanism. This work presents a novel method to predict missing common genes associated with a disease pair. Searching for missing common genes is formulated as an optimization problem to minimize network based module separation from two subgraphs produced by mapping genes associated with disease onto the interactome. Using cross validation on more than 600 disease pairs, our method achieves significantly higher average receiver operating characteristic ROC Score of 0.95 compared to a baseline ROC score 0.60 using randomized data. Missing common genes prediction is aimed to complete gene set associated with comorbid disease for better understanding of biological intervention. It will also be useful for gene targeted therapeutics related to comorbid diseases. This method can be further considered for prediction of missing edges to complete the subgraph associated with disease pair.
An anthropological exploration of contemporary bioethics: the varieties of common sense.

PubMed Central

Turner, L

1998-01-01

Patients and physicians can inhabit distinctive social worlds where they are guided by diverse understandings of moral practice. Despite the contemporary presence of multiple moral traditions, religious communities and ethnic backgrounds, two of the major methodological approaches in bioethics, casuistry and principlism, rely upon the notion of a common morality. However, the heterogeneity of ethnic, moral, and religious traditions raises questions concerning the singularity of common sense. Indeed, it might be more appropriate to consider plural traditions of moral reasoning. This poses a considerable challenge for bioethicists because the existence of plural moral traditions can lead to difficulties regarding "closure" in moral reasoning. The topics of truth-telling, informed consent, euthanasia, and brain death and organ transplantation reveal the presence of different understandings of common sense. With regard to these subjects, plural accounts of "common sense" moral reasoning exist. PMID:9603001
Pavlovian Fear Conditioning Activates a Common Pattern of Neurons in the Lateral Amygdala of Individual Brains

DTIC Science & Technology

2011-01-12

Abstract Understanding the physical encoding of a memory (the engram ) is a fundamental question in neuroscience. Although it has been established...assembly constitutes a spatial dimension of the engram . Citation: Bergstrom HC, McDonald CG, Johnson LR (2011) Pavlovian Fear Conditioning Activates a Common...competing interests exist. * E-mail: LukeJohnsonPhD@gmail.com Introduction Understanding the physical encoding of a memory (the engram ) in neuronal
Common bean proteomics: Present status and future strategies.

PubMed

Zargar, Sajad Majeed; Mahajan, Reetika; Nazir, Muslima; Nagar, Preeti; Kim, Sun Tae; Rai, Vandna; Masi, Antonio; Ahmad, Syed Mudasir; Shah, Riaz Ahmad; Ganai, Nazir Ahmad; Agrawal, Ganesh K; Rakwal, Randeep

2017-10-03

Common bean (Phaseolus vulgaris L.) is a legume of appreciable importance and usefulness worldwide to the human population providing food and feed. It is rich in high-quality protein, energy, fiber and micronutrients especially iron, zinc, and pro-vitamin A; and possesses potentially disease-preventing and health-promoting compounds. The recently published genome sequence of common bean is an important landmark in common bean research, opening new avenues for understanding its genetics in depth. This legume crop is affected by diverse biotic and abiotic stresses severely limiting its productivity. Looking at the trend of increasing world population and the need for food crops best suited to the health of humankind, the legumes will be in great demand, including the common bean mostly for its nutritive values. Hence the need for new research in understanding the biology of this crop brings us to utilize and apply high-throughput omics approaches. In this mini-review our focus will be on the need for proteomics studies in common bean, potential of proteomics for understanding genetic regulation under abiotic and biotic stresses and how proteogenomics will lead to nutritional improvement. We will also discuss future proteomics-based strategies that must be adopted to mine new genomic resources by identifying molecular switches regulating various biological processes. Common bean is regarded as "grain of hope" for the poor, being rich in high-quality protein, energy, fiber and micronutrients (iron, zinc, pro-vitamin A); and possesses potentially disease-preventing and health-promoting compounds. Increasing world population and the need for food crops best suited to the health of humankind, puts legumes into great demand, which includes the common bean mostly. An important landmark in common bean research was the recent publication of its genome sequence, opening new avenues for understanding its genetics in depth. This legume crop is affected by diverse biotic and abiotic stresses severely limiting its productivity. Therefore, the need for new research in understanding the biology of this crop brings us to utilize and apply high-throughput omics approaches. Proteomics can be used to track all the candidate proteins/genes responsible for a biological process under specific conditions in a particular tissue. The potential of proteomics will not only help in determining the functions of a large number of genes in a single experiment but will also be a useful tool to mine new genes that can provide solution to various problems (abiotic stress, biotic stress, nutritional improvement, etc). We believe that a combined approach including breeding along with omics tools will lead towards attaining sustainability in legumes, including common bean. Copyright © 2017 Elsevier B.V. All rights reserved.
Improving Students' Understanding of Electricity and Magnetism

ERIC Educational Resources Information Center

Li, Jing

2012-01-01

Electricity and magnetism are important topics in physics. Research shows that students have many common difficulties in understanding concepts related to electricity and magnetism. However, research to improve students' understanding of electricity and magnetism is limited compared to introductory mechanics. This thesis explores issues…
The Whole Story: Understanding Fraction Computation

ERIC Educational Resources Information Center

Dixon, Juli K.; Tobias, Jennifer M.

2013-01-01

What does it look like to "understand" operations with fractions? The Common Core State Standards for Mathematics (CCSSM) uses the term "understand" when describing expectations for students' knowledge related to each of the fraction operations within grades 4 through 6 (CCSSI 2010). Furthermore, CCSSM elaborates that…
Finding Common Ground with the Common Core

ERIC Educational Resources Information Center

Moisan, Heidi

2015-01-01

This article examines the journey of museum educators at the Chicago History Museum in understanding the Common Core State Standards and implementing them in our work with the school audience. The process raised questions about our teaching philosophy and our responsibility to our audience. Working with colleagues inside and outside of our…
Why Do We Keep Catching the Common Cold?

ERIC Educational Resources Information Center

Gillen, Alan L.; Mayor, Heather D.

1995-01-01

Describes activities for biology teachers that will stimulate discussions on virus structure, cell biology, rhino viruses, and new trends in treating the common cold. Provides opportunity for inquiry and problem solving in exercises that emphasize an understanding of how common cold viruses might pack inside nasal epithelial cells. (14 references)…
Helping Families Understand and Manage Pediatric Gastroesophageal Reflux

ERIC Educational Resources Information Center

Pulsifer-Anderson, Elizabeth

2009-01-01

Gastroesophageal reflux is a common medical problem affecting about 5% of otherwise healthy children. It is extremely common among children with special needs and affects more than half of children with cerebral palsy, Down syndrome, premature birth, and several other common conditions. The disease is becoming more widely recognized, but children…
Common Core in the Real World

ERIC Educational Resources Information Center

Hess, Frederick M.; McShane, Michael Q.

2013-01-01

There are at least four key places where the Common Core intersects with current efforts to improve education in the United States--testing, professional development, expectations, and accountability. Understanding them can help educators, parents, and policymakers maximize the chance that the Common Core is helpful to these efforts and, perhaps…
Transcriptome analysis of two recombinant inbred lines of common bean contrasting for symbiotic nitrogen fixation

USDA-ARS?s Scientific Manuscript database

Common bean (Phaseolus vulgaris L.) is able to fix atmospheric nitrogen (N2) through symbiotic nitrogen fixation (SNF). Effective utilization of existing variability for SNF in common bean for genetic improvement requires an understanding of underlying genes and molecular mechanisms. The utility of ...
Understanding Medical Students' Experience with Stress and Its Related Constructs: A Focus Group Study from Singapore.

PubMed

Farquhar, Julia; Lie, Desiree; Chan, Angelique; Ow, Mandy; Vidyarthi, Arpana

2018-02-01

In order to protect medical students from burnout and its untoward psychiatric effects, it is imperative to understand their stress, burnout, coping, and resilience experiences. This study aimed to derive collective definitions from the medical student perspective, to identify common themes of students' experiences, and to distinguish pre-clinical and clinical year students' experiences relating to these four constructs. The authors conducted focus groups of medical students in Singapore across 4 years using a semi-structured question guide. Participants shared their understanding, experiences, and the relationships between stress, burnout, coping, and resilience. Coders independently evaluated construct definitions and derived common themes through an iterative process, and compared transcripts of pre-clinical and clinical year students to determine differences in experience over time. Nine focus groups (54 students, 28 females, mean age 24.3) were conducted. Students identified common definitions for each construct. Nine themes emerged within three domains: (1) relating constructs to personal experience, (2) interrelating stress, burnout, coping, and resilience, and (3) understanding the necessity of stress. Compared to clinical students, pre-clinical students reported theory-based rather than reality-based experiences and exam-induced stress, defined constructs using present rather than future situations, and described constructs as independent rather than interrelated. This sample of medical students in Singapore shares a common understanding of stress, burnout, coping, and resilience, but experiences these uniquely. They perceive a positive role for stress. These findings build upon prior literature, suggesting an interrelationship between stress and its related constructs and adding the novel perspective of students from an Asian country.
Perspectives on seizure clusters: Gaps in lexicon, awareness, and treatment.

PubMed

Buelow, Janice M; Shafer, Patricia; Shinnar, Ruth; Austin, Joan; Dewar, Sandra; Long, Lucretia; O'Hara, Kathryn; Santilli, Nancy

2016-04-01

Seizure clusters in epilepsy can result in serious outcomes such as missed work or school, postictal psychosis, emergency room visits, or hospitalizations, and yet they are often not included in discussions between health-care professionals (HCPs) and their patients. The purpose of this paper was to describe and compare consumer (patient and caregivers) and professional understanding of seizure clusters and to describe how consumers and HCPs communicate regarding seizure clusters. We reviewed social media discussion sites to explore consumers' understanding of seizure clusters. We analyzed professional (medical) literature to explore the HCPs' understanding of seizure clusters. Major themes were revealed in one or both groups, including: communication about diagnosis; frequency, duration, and time frame; seizure type and pattern; severity; and self-management. When comparing discussions of professionals and consumers, both consumers and clinicians discussed the definition of seizure clusters. Discussions of HCPs were understandably clinically focused, and consumer discussions reflected the experience of seizure clusters; however, both groups struggled with a common lexicon. Seizure cluster events remain a problem associated with serious outcomes. Herein, we outline the lack of a common understanding and recommend the development of a common lexicon to improve communication regarding seizure clusters. Copyright © 2016 Upsher-Smith Laboratories, Inc. Published by Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Labby, Z.

Physicists are often expected to have a solid grounding in experimental design and statistical analysis, sometimes filling in when biostatisticians or other experts are not available for consultation. Unfortunately, graduate education on these topics is seldom emphasized and few opportunities for continuing education exist. Clinical physicists incorporate new technology and methods into their practice based on published literature. A poor understanding of experimental design and analysis could Result in inappropriate use of new techniques. Clinical physicists also improve current practice through quality initiatives that require sound experimental design and analysis. Academic physicists with a poor understanding of design and analysismore » may produce ambiguous (or misleading) results. This can Result in unnecessary rewrites, publication rejection, and experimental redesign (wasting time, money, and effort). This symposium will provide a practical review of error and uncertainty, common study designs, and statistical tests. Instruction will primarily focus on practical implementation through examples and answer questions such as: where would you typically apply the test/design and where is the test/design typically misapplied (i.e., common pitfalls)? An analysis of error and uncertainty will also be explored using biological studies and associated modeling as a specific use case. Learning Objectives: Understand common experimental testing and clinical trial designs, what questions they can answer, and how to interpret the results Determine where specific statistical tests are appropriate and identify common pitfalls Understand the how uncertainty and error are addressed in biological testing and associated biological modeling.« less
Math in Common. Taking Stock of Common Core Math Implementation: Supporting Teachers to Shift Instruction. Insights from the Math in Common 2015 Baseline Survey of Teachers and Administrators. Formative Evaluation Cycle Report for the Math in Common Initiative: Volume 3

ERIC Educational Resources Information Center

Perry, Rebecca R.; Finkelstein, Neal D.; Seago, Nanette; Heredia, Alberto; Sobolew-Shubin, Sandy; Carroll, Cathy

2015-01-01

Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in Mathematics (CCSS-M) across grades K-8. In spring 2015, WestEd administered surveys to understand the perspectives on Common Core State Standards-Mathematics (CCSS-M) implementation…
Insights into Students' Conceptual Understanding Using Textual Analysis: A Case Study in Signal Processing

ERIC Educational Resources Information Center

Goncher, Andrea M.; Jayalath, Dhammika; Boles, Wageeh

2016-01-01

Concept inventory tests are one method to evaluate conceptual understanding and identify possible misconceptions. The multiple-choice question format, offering a choice between a correct selection and common misconceptions, can provide an assessment of students' conceptual understanding in various dimensions. Misconceptions of some engineering…
The Language of Information Literacy: Do Students Understand?

ERIC Educational Resources Information Center

Schaub, Gayle; Cadena, Cara; Bravender, Patricia; Kierkus, Christopher

2017-01-01

To effectively access and use the resources of the academic library and to become information-literate, students must understand the language of information literacy. This study analyzes undergraduate students' understanding of fourteen commonly used information-literacy terms. It was found that some of the terms least understood by students are…
An Investigation into Post-Secondary Students' Understanding of Combinatorial Questions

ERIC Educational Resources Information Center

Bulone, Vincent William

2017-01-01

The purpose of this dissertation was to study aspects of how post-secondary students understand combinatorial problems. Within this dissertation, I considered understanding through two different lenses: i) student connections to previous problems; and ii) common combinatorial distinctions such as ordered versus unordered and repetitive versus…
Science + Maths = A Better Understanding of Science!

ERIC Educational Resources Information Center

Markwick, Andy; Clark, Kris

2016-01-01

Science and mathematics share a common purpose: to explore, understand and explain the pure beauty of our universe and how it works. Using mathematics in science enquiry can enhance children's understanding of science and also provide opportunities for children to apply their mathematical knowledge to "real" contexts. The authors…
The Role of the Sampling Distribution in Understanding Statistical Inference

ERIC Educational Resources Information Center

Lipson, Kay

2003-01-01

Many statistics educators believe that few students develop the level of conceptual understanding essential for them to apply correctly the statistical techniques at their disposal and to interpret their outcomes appropriately. It is also commonly believed that the sampling distribution plays an important role in developing this understanding.…
Understanding cardiovascular disease

MedlinePlus

... page: //medlineplus.gov/ency/patientinstructions/000759.htm Understanding cardiovascular disease To use the sharing features on this page, ... lead to heart attack or stroke. Types of Cardiovascular Disease Coronary heart disease (CHD) is the most common ...
Understanding Common Core State Standards

ERIC Educational Resources Information Center

Kendall, John S.

2011-01-01

Now that the Common Core standards are coming to just about every school, what every school leader needs is a straightforward explanation that lays out the benefits of the Common Core in plain English, provides a succinct overview, and gets everyone thinking about how to transition to this promising new paradigm. This handy, inexpensive booklet…
Information Is a Common Core Dish Best Served First

ERIC Educational Resources Information Center

Walkowiak, Temple A.

2015-01-01

There has been a spike in negative comments about mathematics and standards since the implementation of the Common Core State Standards. Regardless of whether the comments are fueled by social media or traditional media, educators need to be armed with strategies for helping parents understand, navigate, and embrace the Common Core's mathematics…
Professional Development. State Implementation of Common Core State Standards

ERIC Educational Resources Information Center

Anderson, Kimberly; Mira, Mary Elizabeth

2014-01-01

The following profiles address how the state departments of education are helping educators prepare for and implement the Common Core and aligned assessments through professional learning. The major professional development efforts around the Common Core were examined in order to understand the overall efforts of each state. An exhaustive list of…
Understanding Forces: What's the Problem?

ERIC Educational Resources Information Center

Kibble, Bob

2006-01-01

Misconceptions about forces are very common and seem to arise from everyday experience and use of words. Ways to improve students' understanding of forces, as used in recent a IOP CD-Rom, are discussed here.
What Is an Image?

ERIC Educational Resources Information Center

Gerber, Andrew J.; Peterson, Bradley S.

2008-01-01

The article helps to understand the interpretation of an image by presenting as to what constitutes an image. A common feature in all images is the basic physical structure that can be described with a common set of terms.
An RNA-Seq based gene expression atlas of the common bean.

PubMed

O'Rourke, Jamie A; Iniguez, Luis P; Fu, Fengli; Bucciarelli, Bruna; Miller, Susan S; Jackson, Scott A; McClean, Philip E; Li, Jun; Dai, Xinbin; Zhao, Patrick X; Hernandez, Georgina; Vance, Carroll P

2014-10-06

Common bean (Phaseolus vulgaris) is grown throughout the world and comprises roughly 50% of the grain legumes consumed worldwide. Despite this, genetic resources for common beans have been lacking. Next generation sequencing, has facilitated our investigation of the gene expression profiles associated with biologically important traits in common bean. An increased understanding of gene expression in common bean will improve our understanding of gene expression patterns in other legume species. Combining recently developed genomic resources for Phaseolus vulgaris, including predicted gene calls, with RNA-Seq technology, we measured the gene expression patterns from 24 samples collected from seven tissues at developmentally important stages and from three nitrogen treatments. Gene expression patterns throughout the plant were analyzed to better understand changes due to nodulation, seed development, and nitrogen utilization. We have identified 11,010 genes differentially expressed with a fold change ≥ 2 and a P-value < 0.05 between different tissues at the same time point, 15,752 genes differentially expressed within a tissue due to changes in development, and 2,315 genes expressed only in a single tissue. These analyses identified 2,970 genes with expression patterns that appear to be directly dependent on the source of available nitrogen. Finally, we have assembled this data in a publicly available database, The Phaseolus vulgaris Gene Expression Atlas (Pv GEA), http://plantgrn.noble.org/PvGEA/ . Using the website, researchers can query gene expression profiles of their gene of interest, search for genes expressed in different tissues, or download the dataset in a tabular form. These data provide the basis for a gene expression atlas, which will facilitate functional genomic studies in common bean. Analysis of this dataset has identified genes important in regulating seed composition and has increased our understanding of nodulation and impact of the nitrogen source on assimilation and distribution throughout the plant.
The Value of Friction, Tension, and Disparity in Global Collaboration (Invited)

NASA Astrophysics Data System (ADS)

Parsons, M. A.

2013-12-01

Misunderstandings; conflicting goals; competition for limited funds; differing worldviews, agendas, ideals... These types of 'friction' are inevitable in national and global collaboration. And while friction can create tension and conflict, it is not inherently bad. It is at these points of interaction and tension where we can sometimes gain the most insight. Common understanding comes not only through agreed universal principles but also through multiple lines of evidence that wind through disparate views and describe a greater story. Collaboration is not straightforward in an environment of friction, tension, and disparity. Collaborators do not necessarily have common goals. Dynamic, coalition-style politics emerge. How can we align these disparities to achieve standards and common knowledge while still valuing and understanding differing perspectives? Achieving the understanding that comes through both unity and disparity is a central goal of the Research Data Alliance. RDA is emerging as a "neutral place" or "social gateway" where frictions can be identified, addressed, and understood but not necessarily removed.
Contributions of team climate in the study of interprofessional collaboration: A conceptual analysis.

PubMed

Agreli, Heloise F; Peduzzi, Marina; Bailey, Christopher

2017-11-01

The concept of team climate is widely used to understand and evaluate working environments. It shares some important features with Interprofessional Collaboration (IPC). The four-factor theory of climate for work group innovation, which underpins team climate, could provide a better basis for understanding both teamwork and IPC. This article examines in detail the common ground between team climate and IPC, and assesses the relevance of team climate as a theoretical approach to understanding IPC. There are important potential areas of overlap between team climate and IPC that we have grouped under four headings: (1) interaction and communication between team members; (2) common objectives around which collective work is organised; (3) responsibility for performing work to a high standard; and (4) promoting innovation in working practices. These overlapping areas suggest common characteristics that could provide elements of a framework for considering the contribution of team climate to collaborative working, both from a conceptual perspective and, potentially, in operational terms as, for example, a diagnostic tool.
Memory and Common Ground Processes in Language Use

PubMed Central

Brown-Schmidt, Sarah; Duff, Melissa C.

2018-01-01

During communication, we form assumptions about what our communication partners know and believe. Information that is mutually known between the discourse partners—their common ground—serves as a backdrop for successful communication. Here we present an introduction to the focus of this topic, which is the role of memory in common ground and language use. Two types of questions emerge as central to understanding the relationship between memory and common ground, specifically questions having to do with the representation of common ground in memory, and the use of common ground during language processing. PMID:27797165
Ethics and transparent risk communication start with proper risk assessment methodologies

NASA Astrophysics Data System (ADS)

Oboni, Franco; Oboni, Cesar

2014-05-01

We will use throught this paper a "dialogue" between two professionals. One is aware of the misleading character of many risk assessments and wants to foster better approaches. A discomforting set of statements sets the background of the "story": public reactions to risk assessments are generally negative, the developer find it difficult to understand the reasons for general public negative reactions, many projects get often rejected without valid reasons by the public, anywhere in the world. Common practice approaches in Risk Assessment are discussed from the angle of public rejection, taking into account various studies that explicitly expose common practices limitations and voids. The hiatus between rational and well-balanced risk assessments and common practices is explored. Finally solutions to overcome the limitations of common practices and deliver to the public more realistic risk assessment on which to build a widespread consensus are reviewed. The paper conclusions relate to the need of: properly communicating risk throughout the life of a project, from cradle to grave, avoiding conflict of interest, having estimates that are understandable to foster good understanding of what a risk assessment can bring to better Human existence, in an ethical and fair way. The paper delivers a list of possible remedies and shows that "Common Practices" do not equate to "Best Practices": common practices are not to be proposed/used any longer if we want to avoid public distrust and misrepresentations. Many of the "modern" issues ranging from public distrust to insurance denial could be relieved or mitigated ahead of time if misrepresentation was kept at bay using five simple rules. Common practice Risk Assessments, especially those developed under conflict of interest situations, generally misrepresent risks and fail to give the "big picture", hence do not help taking valid decision and are prone to generating/fostering public distrust.
Working across Disciplines to Understand Playful Learning in Educational Settings

ERIC Educational Resources Information Center

van der Aalsvoort, Geerdina; Broadhead, Pat

2016-01-01

Educators stress the importance of play for children's cognitive, social, physical, and emotional development. In order to effectively advocate for the inclusion of play in education settings, it is important to fully understand it. Two researchers, one from England and one from the Netherlands, sought common ground for understanding what children…
Commonalities between Disaster and Climate Change Risks for Health: A Theoretical Framework.

PubMed

Banwell, Nicola; Rutherford, Shannon; Mackey, Brendan; Street, Roger; Chu, Cordia

2018-03-16

Disasters and climate change have significant implications for human health worldwide. Both climate change and the climate-sensitive hazards that result in disasters, are discussed in terms of direct and indirect impacts on health. A growing body of literature has argued for the need to link disaster risk reduction and climate change adaptation. However, there is limited articulation of the commonalities between these health impacts. Understanding the shared risk pathways is an important starting point for developing joint strategies for adapting to, and reducing, health risks. Therefore, this article discusses the common aspects of direct and indirect health risks of climate change and climate-sensitive disasters. Based on this discussion a theoretical framework is presented for understanding these commonalities. As such, this article hopes to extend the current health impact frameworks and provide a platform for further research exploring opportunities for linked adaptation and risk reduction strategies.

Commonalities between Disaster and Climate Change Risks for Health: A Theoretical Framework

PubMed Central

Banwell, Nicola; Rutherford, Shannon; Mackey, Brendan; Street, Roger; Chu, Cordia

2018-01-01

Disasters and climate change have significant implications for human health worldwide. Both climate change and the climate-sensitive hazards that result in disasters, are discussed in terms of direct and indirect impacts on health. A growing body of literature has argued for the need to link disaster risk reduction and climate change adaptation. However, there is limited articulation of the commonalities between these health impacts. Understanding the shared risk pathways is an important starting point for developing joint strategies for adapting to, and reducing, health risks. Therefore, this article discusses the common aspects of direct and indirect health risks of climate change and climate-sensitive disasters. Based on this discussion a theoretical framework is presented for understanding these commonalities. As such, this article hopes to extend the current health impact frameworks and provide a platform for further research exploring opportunities for linked adaptation and risk reduction strategies. PMID:29547592
Improved understanding of the pathophysiology of atrial fibrillation through the lens of discrete pathological pathways

PubMed Central

Balouch, Muhammad A.; Kolek, Matthew J.; Darbar, Dawood

2014-01-01

Atrial fibrillation (AF) is a common disorder with a complex and incompletely understood pathophysiology. Genetic approaches to understanding the pathophysiology of AF have led to the identification of several biological pathways important in the pathogenesis of the arrhythmia. These include pathways important for cardiac development, generation and propagation of atrial electrical impulses, and atrial remodeling and fibrosis. While common and rare genetic variants in these pathways are associated with increased susceptibility to AF, they differ substantially among patients with lone versus typical AF. Furthermore, how these pathways converge to a final common clinical phenotype of AF is unclear and might also vary among different patient populations. Here, we review the contemporary knowledge of AF pathogenesis and discuss how derangement in cardiac development, ion channel dysfunction, and promotion of atrial fibrosis may contribute to this common and important clinical disorder. PMID:25054116
Calculating and Understanding: Formal Models and Causal Explanations in Science, Common Reasoning and Physics Teaching

ERIC Educational Resources Information Center

Besson, Ugo

2010-01-01

This paper presents an analysis of the different types of reasoning and physical explanation used in science, common thought, and physics teaching. It then reflects on the learning difficulties connected with these various approaches, and suggests some possible didactic strategies. Although causal reasoning occurs very frequently in common thought…
Conflict and the Common Good. Studies in Third World Societies, Publication Number Twenty-Four.

ERIC Educational Resources Information Center

Merrill, Robert S., Ed.; Willner, Dorothy, Ed.

The fundamental theme of these papers is what constitutes the common good and the issues and problems related to the understanding of that common good. Several anthropologists and a political scientist explore this theme in various geographic settings and from many theoretical and methodological perspectives. Among the countries and cultures…
Putting Political Spectacle to Work: Understanding Local Resistance to the Common Core

ERIC Educational Resources Information Center

Szolowicz, Michael

2016-01-01

In the fall of 2013, a parents' group formed to protest the new Common Core based mathematics textbook recently adopted by their school district. Quickly allying with teachers, the new coalition began to, "hammer," the district to drop the Common Core and return to more traditional texts and pedagogies. They did so by speaking at…
Young Children's Understanding of Cultural Common Ground

ERIC Educational Resources Information Center

Liebal, Kristin; Carpenter, Malinda; Tomasello, Michael

2013-01-01

Human social interaction depends on individuals identifying the common ground they have with others, based both on personally shared experiences and on cultural common ground that all members of the group share. We introduced 3- and 5-year-old children to a culturally well-known object and a novel object. An experimenter then entered and asked,…
A Methodology to Improving Unity of Effort for Mission Partner Planning

DTIC Science & Technology

2014-06-01

REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE A Methodology to Improving Unity of Effort for Mission Partner... language , or better yet, use a common lexicon (common definitions and terms for greater understanding). One fundamental step toward developing...to attempt to develop strong relationships while learning to speak each other’s language , or better yet, use a common lexicon (common definitions and
Tools of the Trade

ERIC Educational Resources Information Center

Arnold, Kathy

2012-01-01

This article outlines the author's efforts to build her knowledge of students' understandings of mathematics whilst catering for different abilities within a Year 1 classroom, using the freely available "Assessment for Common Misunderstandings tools." "The Assessment for Common Misunderstandings" materials have been…
QTL variations for growth-related traits in eight distinct families of common carp (Cyprinus carpio).

PubMed

Lv, Weihua; Zheng, Xianhu; Kuang, Youyi; Cao, Dingchen; Yan, Yunqin; Sun, Xiaowen

2016-05-05

Comparing QTL analyses of multiple pair-mating families can provide a better understanding of important allelic variations and distributions. However, most QTL mapping studies in common carp have been based on analyses of individual families. In order to improve our understanding of heredity and variation of QTLs in different families and identify important QTLs, we performed QTL analysis of growth-related traits in multiple segregating families. We completed a genome scan for QTLs that affect body weight (BW), total length (TL), and body thickness (BT) of 522 individuals from eight full-sib families using 250 microsatellites evenly distributed across 50 chromosomes. Sib-pair and half-sib model mapping identified 165 QTLs on 30 linkage groups. Among them, 10 (genome-wide P <0.01 or P < 0.05) and 28 (chromosome-wide P < 0.01) QTLs exhibited significant evidence of linkage, while the remaining 127 exhibited a suggestive effect on the above three traits at a chromosome-wide (P < 0.05) level. Multiple QTLs obtained from different families affect BW, TL, and BT and locate at close or identical positions. It suggests that same genetic factors may control variability in these traits. Furthermore, the results of the comparative QTL analysis of multiple families showed that one QTL was common in four of the eight families, nine QTLs were detected in three of the eight families, and 26 QTLs were found common to two of the eight families. These common QTLs are valuable candidates in marker-assisted selection. A large number of QTLs were detected in the common carp genome and associated with growth-related traits. Some of the QTLs of different growth-related traits were identified at similar chromosomal regions, suggesting a role for pleiotropy and/or tight linkage and demonstrating a common genetic basis of growth trait variations. The results have set up an example for comparing QTLs in common carp and provided insights into variations in the identified QTLs affecting body growth. Discovery of these common QTLs between families and growth-related traits represents an important step towards understanding of quantitative genetic variation in common carp.
Self-reported acute health symptoms and exposure to companion animals

EPA Science Inventory

Background: In order to understand the etiological burden of disease associated with acute health symptoms (e.g. gastrointestinal [GI], respiratory, dermatological), it is important to understand how common exposures influence these symptoms. Exposures to familiar and unfamiliar ...
Why media relations matter.

PubMed

Kureczka, Joan E

2006-04-01

There is a common misperception that only medium- and large-cap biotechs need to understand and interact with the media. As investor demands increase and partnering dynamics evolve, startups need to understand the art of media relations more now than ever before.
A Study of Nigerian Pupils' Understanding of Selected Biological Concepts.

ERIC Educational Resources Information Center

Okeke, Eunice A. C.; Wood-Robinson, Colin

1980-01-01

Describes results of a study investigating the nature of Nigerian secondary school pupils' (N=120) difficulties in understanding the biological concepts of growth, reproduction, and transport mechanisms within living organisms. Identifies examples of common misconceptions. (CS)
Teaching to the Core: Integrating Implementation of Common Core and Teacher Effectiveness Policies

ERIC Educational Resources Information Center

Wiener, Ross

2013-01-01

The purpose of the Common Core State Standards is to prepare students to succeed in college and career pursuits. To that end, the Common Core calls on teachers to focus on deepening students' understanding of what they're learning, enhancing their problem-solving skills, and improving their ability to communicate ideas. At the same time, states…
Management of common head and neck masses.

PubMed

Tracy, Thomas F; Muratore, Christopher S

2007-02-01

Head and neck masses are a common clinical concern in infants, children, and adolescents. The differential diagnosis for a head or neck mass includes congenital, inflammatory, and neoplastic lesions. An orderly and thorough examination of the head and neck with an appropriate directed workup will facilitate the diagnosis. The most common entities occur repeatedly within the various age groups and can be differentiated with a clear understanding of embryology and anatomy of the region, and an understanding of the natural history of a specific lesion. Congenital lesions most commonly found in the pediatric population include the thyroglossal duct cyst and the branchial cleft and arch anomalies. The inflammatory masses are secondary to local or systemic infections. The most common etiology for cervical adenopathy in children is reactive lymphadenopathy following a viral or bacterial illness. Persistent adenopathy raises more concerns, especially enlarged lymph nodes within the posterior triangle or supraclavicular space, nodes that are painless, firm, and not mobile, or a single dominant node that persists for more than 6 weeks should all heighten concern for malignancy. In this review, we discuss the current principles of surgical management of the most common head and neck masses that present to pediatricians and pediatric surgeons.
Memory and Common Ground Processes in Language Use.

PubMed

Brown-Schmidt, Sarah; Duff, Melissa C

2016-10-01

During communication, we form assumptions about what our communication partners know and believe. Information that is mutually known between the discourse partners-their common ground-serves as a backdrop for successful communication. Here we present an introduction to the focus of this topic, which is the role of memory in common ground and language use. Two types of questions emerge as central to understanding the relationship between memory and common ground, specifically questions having to do with the representation of common ground in memory, and the use of common ground during language processing. Copyright © 2016 Cognitive Science Society, Inc.
Diagnosis and management of common gastrointestinal tract infectious diseases in ulcerative colitis and Crohn's disease patients.

PubMed

Landsman, Marc J; Sultan, Mohamed; Stevens, Michael; Charabaty, Aline; Mattar, Mark C

2014-12-01

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, stretches beyond control of flares. Some infections of the gastrointestinal tract are more commonly seen in patients with IBD. Work from the Human Microbiome Project has been instrumental in our understanding of the interplay between the vast gut microbiota and host immune responses. Patients with IBD may be more prone to infectious complications based on their underlying inflammatory disease and variations in their microbiome. Immunosuppressant medications commonly used to treat patients with Crohn's and colitis also play a role in predisposing these patients to acquire these infections. Here, we present a detailed review of the data focusing on the most common infections of the gastrointestinal tract in patients with IBD: Clostridium difficile infections (CDI) and cytomegalovirus (CMV). We will discuss appropriate diagnostic tools and treatment options for these infections. Other less common infections will also be reviewed briefly. Studying the various infections of the gastrointestinal tract in these patients could enhance our understanding of the pathophysiology of IBD.
Infectious mononucleosis and the spleen.

PubMed

Kinderknecht, James J

2002-04-01

Infectious mononucleosis is an extremely common problem in the athletic population. "Mono" occurs in 3% of college students. Diagnosing infectious mononucleosis requires an understanding of the clinical features such as fever, lymphadenopathy, pharyngitis, and splenomegaly, as well as laboratory findings. The time at which these clinical features and laboratory abnormalities develop is also important to understand. Splenomegaly is common, but splenic rupture is very rare. Whether an athlete may return to activity usually relates to the presence of splenomegaly and the duration of the illness. Splenic rupture has not been reported after an individual has been ill for more than 3 weeks. This article provides an overview of infectious mononucleosis. The most common complications are reviewed and the management of these problems discussed. A practical approach to determining when an athlete may return to activity is presented.
Improving the cost effectiveness of financial incentives in managing travel demand management (TDM) : [technical summary].

DOT National Transportation Integrated Search

2013-10-01

During the last two decades, financial incentives : have become common in efforts to reduce : demand on roadways by motivating commuters to : use alternative modes of transportation. Despite : common use, limited effort has been made to : understand ...
Building a Values-Informed Mental Model for New Orleans Climate Risk Management.

PubMed

Bessette, Douglas L; Mayer, Lauren A; Cwik, Bryan; Vezér, Martin; Keller, Klaus; Lempert, Robert J; Tuana, Nancy

2017-10-01

Individuals use values to frame their beliefs and simplify their understanding when confronted with complex and uncertain situations. The high complexity and deep uncertainty involved in climate risk management (CRM) lead to individuals' values likely being coupled to and contributing to their understanding of specific climate risk factors and management strategies. Most mental model approaches, however, which are commonly used to inform our understanding of people's beliefs, ignore values. In response, we developed a "Values-informed Mental Model" research approach, or ViMM, to elicit individuals' values alongside their beliefs and determine which values people use to understand and assess specific climate risk factors and CRM strategies. Our results show that participants consistently used one of three values to frame their understanding of risk factors and CRM strategies in New Orleans: (1) fostering a healthy economy, wealth, and job creation, (2) protecting and promoting healthy ecosystems and biodiversity, and (3) preserving New Orleans' unique culture, traditions, and historically significant neighborhoods. While the first value frame is common in analyses of CRM strategies, the latter two are often ignored, despite their mirroring commonly accepted pillars of sustainability. Other values like distributive justice and fairness were prioritized differently depending on the risk factor or strategy being discussed. These results suggest that the ViMM method could be a critical first step in CRM decision-support processes and may encourage adoption of CRM strategies more in line with stakeholders' values. © 2017 Society for Risk Analysis.
Framework for Understanding Intercultural Perspective Taking in Operational Settings

DTIC Science & Technology

2016-02-01

Child Development , 42, 1721-1734. Selmeski, B. R. (2007). Military cross-cultural competence: Core concepts and individual development . Centre for...community and can also serve as a common reference for the development community to direct training and assessment initiatives. 15. SUBJECT TERMS...research effort was to develop an understanding of intercultural perspective taking (IPT) in operational settings. To represent this understanding, a

Applying the Common Sense Model to Understand Representations of Arsenic Contaminated Well Water

PubMed Central

Severtson, Dolores J.; Baumann, Linda C.; Brown, Roger L.

2015-01-01

Theory-based research is needed to understand how people respond to environmental health risk information. The common sense model of self-regulation and the mental models approach propose that information shapes individual’s personal understandings that influence their decisions and actions. We compare these frameworks and explain how the common sense model (CSM) was applied to describe and measure mental representations of arsenic contaminated well water. Educational information, key informant interviews, and environmental risk literature were used to develop survey items to measure dimensions of cognitive representations (identity, cause, timeline, consequences, control) and emotional representations. Surveys mailed to 1067 private well users with moderate and elevated arsenic levels yielded an 84% response rate (n=897). Exploratory and confirmatory factor analyses of data from the elevated arsenic group identified a factor structure that retained the CSM representational structure and was consistent across moderate and elevated arsenic groups. The CSM has utility for describing and measuring representations of environmental health risks thus supporting its application to environmental health risk communication research. PMID:18726811
Modeling a Common-Source Amplifier Using a Ferroelectric Transistor

NASA Technical Reports Server (NTRS)

Sayyah, Rana; Hunt, Mitchell; MacLeond, Todd C.; Ho, Fat D.

2010-01-01

This paper presents a mathematical model characterizing the behavior of a common-source amplifier using a FeFET. The model is based on empirical data and incorporates several variables that affect the output, including frequency, load resistance, and gate-to-source voltage. Since the common-source amplifier is the most widely used amplifier in MOS technology, understanding and modeling the behavior of the FeFET-based common-source amplifier will help in the integration of FeFETs into many circuits.
Advancing our understanding of charcoal rot in soybeans

USDA-ARS?s Scientific Manuscript database

Charcoal rot (Macrophomina phaseolina (Tassi) Goid ) of soybean [Glycine max (L.) Merr.], is an important but commonly misidentified disease, and very few summary articles exist on this pathosystem. Research conducted over the last 10 years has improved our understanding of the environment conducive...
Preparation for Careers--Not Jobs

ERIC Educational Resources Information Center

Worthy, James C.

1977-01-01

Sangamon State University's experimental management program has demonstrated the fundamental soundness of the generic approach. Application of common principles to a variety of organizational situations contributes to a better understanding of those principles and helps students understand the differences between organizations and how to adapt to…
Professional Noticing: Developing Responsive Mathematics Teaching

ERIC Educational Resources Information Center

Thomas, Jonathan N.; Eisenhardt, Sara; Fisher, Molly H.; Schack, Edna O.; Tassell, Janet; Yoder, Margaret

2014-01-01

Thoughtful implementation of the Common Core State Standards for Mathematics (CCSSM) (CCSSI 2010) presents an opportunity for increased emphasis on the development of mathematical understanding among students. Granted, ascertaining the mathematical understanding of an individual student is highly complex work and often exceedingly difficult.…
Common Student Misconceptions in Exercise Physiology and Biochemistry

ERIC Educational Resources Information Center

Morton, James P.; Doran, Dominic A.; MacLaren, Don P. M.

2008-01-01

The present study represents a preliminary investigation designed to identify common misconceptions in students' understanding of physiological and biochemical topics within the academic domain of sport and exercise sciences. A specifically designed misconception inventory (consisting of 10 multiple-choice questions) was administered to a cohort…
Ethical concerns: comparison of values from two cultures.

PubMed

Wros, Peggy L; Doutrich, Dawn; Izumi, Shigeko

2004-06-01

The present study was a secondary analysis of data from two phenomenological studies of nurses in the USA and Japan. The study incorporated hermeneutics and feminist methodologies to answer the following questions. Are there common values and ethical concerns and values within the nursing cultures of Japan and the USA? What are some commonalities and differences between Japanese nurses' ethical concerns and those of American nurses? Findings indicated that nurses from the USA and Japan share common values and ethical concerns as professional nurses, including competence, respect for the patient as a person, responsibility, relationship and connection, importance of the family, caring, good death, comfort, truth-telling, understanding the patient/situation, and anticipatory care. Although ethical concerns are similar, related background meanings and actions often look different between cultures; truth-telling is described as an example. Nurses in each country also hold unique values not found in the nursing practice of the other country. Understanding these commonalities and differences is critical for the development of global nursing ethics.
Ventromedial prefrontal cortex damage does not impair the development and use of common ground in social interaction: Implications for cognitive theory of mind

PubMed Central

Gupta, Rupa; Tranel, Daniel; Duff, Melissa C.

2011-01-01

During conversation, interactants draw on their shared communicative context and history (“common ground”) to help decide what to say next, tailoring utterances based on their knowledge of what the listener knows. The use of common ground draws on an understanding of the thoughts and feelings of others to create and update a model of what is known by the other person, employing cognitive processes such as theory of mind. We tested the hypothesis that the ventromedial prefrontal cortex (vmPFC), a neural region involved in processing and interpreting social and emotional information, would be critical for the development and use of common ground. We studied seven patients with bilateral vmPFC damage and seven age-, sex-, and education-matched healthy comparison participants, each interacting with a familiar partner. Across 24 trials, participants verbally directed their partners how to arrange a set of 12 abstract tangram cards. Our hypothesis was not supported: the vmPFC and healthy comparison groups showed similar development and use of common ground, evident in reduction in time and words used to describe the cards, similar increases in the use of definite references (e.g., the horse), and comparable use of verbal play (playful language) in their interactions. These results argue against the idea that the vmPFC is critical for the development and use of common ground in social interaction. We propose that a cognitive and neuroanatomical bifurcation in theory of mind processes may explain this outcome. The vmPFC may be important for affective theory of mind (the ability to understand another’s feelings); however, the development and use of common ground in social interaction may place higher demands on the ability to understand another’s knowledge, or cognitive theory of mind, which may not require the vmPFC. PMID:22120006
Characterization of Medicago truncatula reduced calcium oxalate crystal mutant alleles

USDA-ARS?s Scientific Manuscript database

Calcium oxalate crystal formation is common in plants. Formation of these crystals has been shown to function in plant defense, calcium regulation, and aluminum tolerance. Although calcium oxalate is common and plays important roles in plant development, our understanding of how these crystals form ...
Rainwater harvesting in the United States: a survey of common system practices

EPA Science Inventory

Rainwater harvesting (RWH) systems in the United States vary in terms of design and operation. To better understand common practices in the RWH community and motivation for collecting harvested rainwater, an electronic survey was used to poll members of the American Rainwater Cat...
Transition Framingham: The Cultural Commons in Action

ERIC Educational Resources Information Center

Burke, Emily Kearns

2017-01-01

This chapter examines the revitalization of the cultural commons in one Massachusetts community. The adult learning theory of situated cognition, specifically communities of practice and cognitive apprenticeship, provides a lens through which to better understand how knowledge sharing can effectively promote localization in an effort to mitigate…
Revisiting the Common Myths about Homeschooling

ERIC Educational Resources Information Center

Romanowski, Michael H.

2006-01-01

The author examines four common myths that still influence individuals regarding their perspective and understanding of the role homeschooling plays in the education of American children. Myth 1 is that homeschooling produces social misfits, stemming from the belief that homeschooled students lack the socialization skills necessary for normal…
School Counseling Principles: Foundations and Basics

ERIC Educational Resources Information Center

American School Counselor Association (Bks), 2006

2006-01-01

This book serves as a ready reference for advancing a common understanding of the rapidly evolving school counseling profession. Its purpose is to help school counselors, school counseling students, educators, administrators and other school counseling stakeholders best converge on the most highly agreed upon responses to common professional…
Common Topics and Commonplaces of Environmental Rhetoric

ERIC Educational Resources Information Center

Ross, Derek G.

2013-01-01

Common topics are words or phrases used to develop argument, and commonplaces aid memory or catalyze frames of understanding. When used in argumentation, each may help interested parties more effectively communicate valuable scientific and environment-related information. This article describes 12 modern topics of environmental rhetoric,…
Pooling the ground: understanding and coordination in collective sense making

PubMed Central

Rączaszek-Leonardi, Joanna; Dębska, Agnieszka; Sochanowicz, Adam

2014-01-01

Common ground is most often understood as the sum of mutually known beliefs, knowledge, and suppositions among the participants in a conversation. It explains why participants do not mention things that should be obvious to both. In some accounts of communication, reaching a mutual understanding, i.e., broadening the common ground, is posed as the ultimate goal of linguistic interactions. Yet, congruent with the more pragmatic views of linguistic behavior, in which language is treated as social coordination, understanding each other is not the purpose (or not the sole purpose) of linguistic interactions. This purpose is seen as at least twofold (e.g., Fusaroli et al., 2014): to maintain the systemic character of a conversing dyad and to organize it into a functional synergy in the face of tasks posed for a dyadic system as a whole. It seems that the notion of common ground is not sufficient to address the latter character of interaction. In situated communication, in which meaning is created in a distributed way in the very process of interaction, both common (sameness) and privileged (diversity) information must be pooled task-dependently across participants. In this paper, we analyze the definitions of common and privileged ground and propose a conceptual extension that may facilitate a theoretical account of agents that coordinate via linguistic communication. To illustrate the usefulness of this augmented framework, we apply it to one of the recurrent issues in psycholinguistic research, namely the problem of perspective-taking in dialog, and draw conclusions for the broader problem of audience design. PMID:25426087
The molecular genetics of holoprosencephaly

PubMed Central

Roessler, Erich; Muenke, Maximilian

2009-01-01

Holoprosencephaly (or HPE) has captivated the imagination of Man for millennia because its most extreme manifestation, the single-eyed cyclopic newborn infant, brings to mind the fantastical creature Cyclops from Greek mythology. Attempting to understand this common malformation of the forebrain in modern medical terms requires a systematic synthesis of genetic, cytogenetic and environmental information typical for studies of a complex disorder. However, even with the advances in our understanding of HPE in recent years, there are significant obstacles remaining to fully understand its heterogeneity and extensive variability in phenotype. General lessons learned from HPE will likely be applicable to other malformation syndromes. Here we outline the common, and rare, genetic and environmental influences on this conserved developmental program of forebrain development and illustrate the similarities and differences between these malformations in humans and those of animal models. PMID:20104595
The molecular genetics of holoprosencephaly.

PubMed

Roessler, Erich; Muenke, Maximilian

2010-02-15

Holoprosencephaly (HPE) has captivated the imagination of Man for millennia because its most extreme manifestation, the single-eyed cyclopic newborn infant, brings to mind the fantastical creature Cyclops from Greek mythology. Attempting to understand this common malformation of the forebrain in modern medical terms requires a systematic synthesis of genetic, cytogenetic, and environmental information typical for studies of a complex disorder. However, even with the advances in our understanding of HPE in recent years, there are significant obstacles remaining to fully understand its heterogeneity and extensive variability in phenotype. General lessons learned from HPE will likely be applicable to other malformation syndromes. Here we outline the common, and rare, genetic and environmental influences on this conserved developmental program of forebrain development and illustrate the similarities and differences between these malformations in humans and those of animal models. 2010 Wiley-Liss, Inc.
Anticipation Guides: Reading for Mathematics Understanding

ERIC Educational Resources Information Center

Adams, Anne E.; Pegg, Jerine; Case, Melissa

2015-01-01

With the acceptance by many states of the Common Core State Standards for Mathematics, new emphasis is being placed on students' ability to engage in mathematical practices such as understanding problems (including word problems), reading and critiquing arguments, and making explicit use of definitions (CCSSI 2010). Engaging students in…
Asking the Right Questions: Helping Mainstream Students Understand Other Cultures.

ERIC Educational Resources Information Center

Taylor, Jefferey H.

Two common tendencies that lead many mainstream students to misinterpret other cultures are the combative response and the exoticizing response. These misinterpretations, however, can be excellent learning moments for helping students understand the constructed nature of culture and the contextual nature of learning. Transformational multicultural…
29 CFR 779.324 - Recognition “in.”

Code of Federal Regulations, 2010 CFR

2010-07-01

... in any particular industry the power to exempt themselves from the requirements of the Act. It was..., traditional understanding and common knowledge. These involve the understanding and knowledge of the purchaser... and others who have knowledge of recognized classifications in an industry, would all be relevant in...

Toward understanding mechanisms controlling urea delivery in a coastal plain watershed

USDA-ARS?s Scientific Manuscript database

Improved understanding of nutrient mobilization and delivery to surface waters is critical to protecting water quality in agricultural watersheds. Urea, a form of organic nitrogen, is a common nutrient found in fertilizers, manures, and human waste, and is gaining recognition as an important driver ...
Critical Theory and Teaching Literacy.

ERIC Educational Resources Information Center

King, James R.

A broad base for understanding what critical literacy is can be created by understanding three views of critical theory: critical social theory, feminist theory, and child advocacy. When each is brought to bear on the schooling rituals associated with literacy instruction, interesting commonalities among the three views emerge. Critical approaches…
Scaling of Advanced Theory-of-Mind Tasks

ERIC Educational Resources Information Center

Osterhaus, Christopher; Koerber, Susanne; Sodian, Beate

2016-01-01

Advanced theory-of-mind (AToM) development was investigated in three separate studies involving 82, 466, and 402 elementary school children (8-, 9-, and 10-year-olds). Rasch and factor analyses assessed whether common conceptual development underlies higher-order false-belief understanding, social understanding, emotion recognition, and…
Enhancing Understanding of Transformation Matrices

ERIC Educational Resources Information Center

Dick, Jonathan; Childrey, Maria

2012-01-01

With the Common Core State Standards' emphasis on transformations, teachers need a variety of approaches to increase student understanding. Teaching matrix transformations by focusing on row vectors gives students tools to create matrices to perform transformations. This empowerment opens many doors: Students are able to create the matrices for…
A mechanist understanding of tree responses to thinning and fertilization from stable isotopes in tree rings

EPA Science Inventory

Carbon sequestration and the possible associated economic credits have focused renewed interest in understanding how forest management affects forest growth over timescales of decades. Two of the most common forest management tools are thinning and fertilization, and yet details ...
Provocative Opinion: Can Chemistry be Learned Without Understanding?

ERIC Educational Resources Information Center

Sanderson, R. T.

1974-01-01

Voices the opinion that clearer and more useful explanations of common chemistry are needed to facilitate understanding. Presents examples from the realms of atomic structure, periodic table, history of chemistry, valence, electronegativity, electrode potentials, covalent bonds, polar covalence, bond energy, and causes of chemical change. (GS)
Null Element Restoration

ERIC Educational Resources Information Center

Gabbard, Ryan

2010-01-01

Understanding the syntactic structure of a sentence is a necessary preliminary to understanding its semantics and therefore for many practical applications. The field of natural language processing has achieved a high degree of accuracy in parsing, at least in English. However, the syntactic structures produced by the most commonly used parsers…
Understanding the Complexities of Student Motivations in Mathematics Learning

ERIC Educational Resources Information Center

Walter, Janet G.; Hart, Janelle

2009-01-01

Student motivation has long been a concern of mathematics educators. However, commonly held distinctions between intrinsic and extrinsic motivations may be insufficient to inform our understandings of student motivations in learning mathematics or to appropriately shape pedagogical decisions. Here, motivation is defined, in general, as an…
Starting Over: Current Issues in Online Catalog User Interface Design.

ERIC Educational Resources Information Center

Crawford, Walt

1992-01-01

Discussion of online catalogs focuses on issues in interface design. Issues addressed include understanding the user base; common user access (CUA) with personal computers; common command language (CCL); hyperlinks; screen design issues; differences from card catalogs; indexes; graphic user interfaces (GUIs); color; online help; and remote users.…
Common-Sense Chemistry: The Use of Assumptions and Heuristics in Problem Solving

ERIC Educational Resources Information Center

Maeyer, Jenine Rachel

2013-01-01

Students experience difficulty learning and understanding chemistry at higher levels, often because of cognitive biases stemming from common sense reasoning constraints. These constraints can be divided into two categories: assumptions (beliefs held about the world around us) and heuristics (the reasoning strategies or rules used to build…
Clear Skies Ahead! Clearing up Confusion about Clouds

ERIC Educational Resources Information Center

Cartwright, Tina J.; Miranda, Rommel J.; Hermann, Ronald S.; Hemler, Deb

2012-01-01

In this article, the authors present an inquiry-based approach to facilitate student understanding of the differences among common cloud descriptive characteristics through the use of a semi-dichotomous key developed by a former West Virginia state climatologist. The authors also demonstrate how students can analyze common class data sets that…
Identifying and Reconstructing Common Cold Misconceptions among Developing K-12 Educators

ERIC Educational Resources Information Center

Johnson, Marcus Lee; Bungum, Timothy

2013-01-01

Background: Common cold misconceptions may contribute to ill-informed decisions and recommendations made by K-12 educators who often encounter infected students. Understanding the structure of educators' misconceptions can be used to improve health instruction in teacher professional preparation programs. Purpose: The purposes of this project were…
Sports-specific injuries.

PubMed

Plancher, K D; Minnich, J M

1996-04-01

Injuries to the upper extremities can happen in any sport. Injury patterns are common to specific sports. Understanding which injuries occur with these sports allows the examiner to diagnose and treat the athlete easily. This article reviews some of the injuries common in sports such as bicycling, golf, gymnastics, martial arts, racquet sports, and weightlifting.
Working Together Toward a Common Goal: A Grounded Theory of Nurse-Physician Collaboration.

PubMed

Fewster-Thuente, Lori

2015-01-01

Working together toward a common goal is an empirically derived theory that can guide education and practice to improve patient outcomes while saving money and lives. Grounded theory was used to explore nurses' and physicians' experiences with collaboration in order to understand the process intrinsically.
A Psychometric Framework for the Evaluation of Instructional Sensitivity

ERIC Educational Resources Information Center

Naumann, Alexander; Hochweber, Jan; Klieme, Eckhard

2016-01-01

Although there is a common understanding of instructional sensitivity, it lacks a common operationalization. Various approaches have been proposed, some focusing on item responses, others on test scores. As approaches often do not produce consistent results, previous research has created the impression that approaches to instructional sensitivity…
Founding concepts for tree breeding and research

Treesearch

Hyun Kang

1983-01-01

Forestry research is a multidisciplinary venture and is typically a long-term effort with relatively low funding. The success of forestry research and tree breeding depends greatly on the coordination among forestry practitioners, research managers, and researchers. To coordinate they must have a common understanding of the research process. Therefore, the common...
Beyond Multiple Regression: Using Commonality Analysis to Better Understand R[superscript 2] Results

ERIC Educational Resources Information Center

Warne, Russell T.

2011-01-01

Multiple regression is one of the most common statistical methods used in quantitative educational research. Despite the versatility and easy interpretability of multiple regression, it has some shortcomings in the detection of suppressor variables and for somewhat arbitrarily assigning values to the structure coefficients of correlated…
Pre-epidemic mortality rates for common Phytophthora ramorum host tree species in California

Treesearch

T.M. Barrett

2006-01-01

Understanding the impacts of Phytophthora ramorum on forests will require knowledge of pre-disease distribution, abundance, and rates of change for affected species. This study estimated pre-epidemic mortality rates for nine common host tree species: bigleaf maple (Acer macrophyllum), California bay laurel (Umbellularia...
Performance Analysis of Saturated Induction Motors by Virtual Tests

ERIC Educational Resources Information Center

Ojaghi, M.; Faiz, J.; Kazemi, M.; Rezaei, M.

2012-01-01

Many undergraduate-level electrical machines textbooks give detailed treatments of the performance of induction motors. Students can deepen this understanding of motor performance by performing the appropriate practical work in laboratories or in simulation using proper software packages. This paper considers various common and less-common tests…
Economic Issues in Mass Communication Industries.

ERIC Educational Resources Information Center

Rosse, James N.; Dertouzos, James N.

A general discussion covering both the common problems and features of the full range of the mass media industries, and some economic notions central to understanding them, opens this report, followed by introductory essays for individual industries and consideration of public policy issues. The basic economic considerations common to the field…

Making Sense of Fear Testing - Validating Common Behavioral Tests used in Swine

USDA-ARS?s Scientific Manuscript database

Tests to assess fear are commonly used in laboratory animals, such as mice and rats, when researchers wish to understand the implications of specific drugs, such as anxiolytics, or specific environments which may be used to house experimental animals. Researchers who study the welfare of livestock ...
Natural Learning Case Study Archives

ERIC Educational Resources Information Center

Lawler, Robert W.

2015-01-01

Natural Learning Case Study Archives (NLCSA) is a research facility for those interested in using case study analysis to deepen their understanding of common sense knowledge and natural learning (how the mind interacts with everyday experiences to develop common sense knowledge). The database comprises three case study corpora based on experiences…
A Molecular Framework for Understanding DCIS

DTIC Science & Technology

2017-10-01

common form of breast cancer. IDC accounts for 80% of all breast cancers, predominantly affecting women aged 55 and older; however, at least a third of...Carcinoma (IDC), the most common form of breast cancer. IDC accounts for 80% of all breast cancers, predominantly affecting women aged 55 and older
In Search of Common Threads: Linking Multicultural, Feminist, and Social Justice Counseling Paradigms

ERIC Educational Resources Information Center

Crethar, Hugh C.; Rivera, Edil Torres; Nash, Sara

2008-01-01

Multicultural, feminist, and social justice counseling theories are often viewed as disparate helping models. This article examines the complementary nature of these models and discusses the need to promote a clearer understanding of the ways in which these common threads can be used in counseling practice.
Data Safe Havens and Trust: Toward a Common Understanding of Trusted Research Platforms for Governing Secure and Ethical Health Research

PubMed Central

Nicholls, Jacqueline; Dobbs, Christine; Sethi, Nayha; Cunningham, James; Ainsworth, John; Heaven, Martin; Peacock, Trevor; Peacock, Anthony; Jones, Kerina; Laurie, Graeme; Kalra, Dipak

2016-01-01

In parallel with the advances in big data-driven clinical research, the data safe haven concept has evolved over the last decade. It has led to the development of a framework to support the secure handling of health care information used for clinical research that balances compliance with legal and regulatory controls and ethical requirements while engaging with the public as a partner in its governance. We describe the evolution of 4 separately developed clinical research platforms into services throughout the United Kingdom-wide Farr Institute and their common deployment features in practice. The Farr Institute is a case study from which we propose a common definition of data safe havens as trusted platforms for clinical academic research. We use this common definition to discuss the challenges and dilemmas faced by the clinical academic research community, to help promote a consistent understanding of them and how they might best be handled in practice. We conclude by questioning whether the common definition represents a safe and trustworthy model for conducting clinical research that can stand the test of time and ongoing technical advances while paying heed to evolving public and professional concerns. PMID:27329087
Understanding Copyright and Fair Use in the Music Classroom

ERIC Educational Resources Information Center

Drummond, Tim

2015-01-01

Many music educators do not sufficiently understand the complicated system of U.S. copyright law or what constitutes "fair use," resulting in both illegal and overly conservative practices. Increasingly accessible recording and distribution technology has also led to common practices such as posting performances on YouTube, creating…
Explaining the Significance of Participationist Approaches for Understanding Students' Knowledge Acquisition

ERIC Educational Resources Information Center

Dohn, Nina Bonderup

2016-01-01

This article aims to appraise insights from participationist approaches to learning for understanding students' knowledge acquisition. The first part explicates the concepts of positioning, recognition, and identity through presenting a common ground for participationists and discussing different views on (a) the relationship between learning the…
Phonetics and Phonology of Thematic Contrast in German

ERIC Educational Resources Information Center

Braun, Bettina

2006-01-01

It is acknowledged that contrast plays an important role in understanding discourse and information structure. While it is commonly assumed that contrast can be marked by intonation only, our understanding of the intonational realization of contrast is limited. For German there is mainly introspective evidence that the rising theme accent (or…
Understanding Economic Abuse in the Lives of Survivors

ERIC Educational Resources Information Center

Postmus, Judy L.; Plummer, Sara-Beth; McMahon, Sarah; Murshid, N. Shaanta; Kim, Mi Sung

2012-01-01

Intimate partner violence (IPV) often includes economic abuse as one tactic commonly used by an abuser; unfortunately, there is a lack of empirical understanding of economic abuse. Additionally, research is limited on the predictors of economic self-sufficiency in the lives of women experiencing IPV. This paper furthers our knowledge about…
Understanding Place Value

ERIC Educational Resources Information Center

Cooper, Linda L.; Tomayko, Ming C.

2011-01-01

Developing an understanding of place value and the base-ten number system is considered a fundamental goal of the early primary grades. For years, teachers have anecdotally reported that students struggle with place-value concepts. Among the common errors cited are misreading such numbers as 26 and 62 by seeing them as identical in meaning,…
Science 20-30: Program of Studies.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Curriculum Branch.

Presented in both English and French, Science 20-30 is an integrated academic program in Alberta, Canada that helps students better understand and apply fundamental concepts and skills common to biology, chemistry, physics, and the Earth sciences. The major goals of the program are: (1) to develop in students an understanding of the…
Science 10: Course of Studies.

ERIC Educational Resources Information Center

Alberta Dept. of Education, Edmonton. Curriculum Branch.

Presented in both English and French, Science 10 is an integrated academic course that helps students in Alberta, Canada better understand and apply fundamental concepts and skills common to biology, chemistry, physics, and the Earth sciences. The major goals of the program are: (1) to develop in students an understanding of the interconnecting…
Supporting Mathematical Discussions: The Roles of Comparison and Cognitive Load

ERIC Educational Resources Information Center

Richland, Lindsey E.; Begolli, Kreshnik Nasi; Simms, Nina; Frausel, Rebecca R.; Lyons, Emily A.

2016-01-01

Mathematical discussions in which students compare alternative solutions to a problem can be powerful modes for students to engage and refine their misconceptions into conceptual understanding, as well as to develop understanding of the mathematics underlying common algorithms. At the same time, these discussions are challenging to lead…
Supporting Mathematical Discussions: The Roles of Comparison and Cognitive Load

ERIC Educational Resources Information Center

Richland, Lindsey E.; Begolli, Kreshnik Nasi; Simms, Nina; Frausel, Rebecca R.; Lyons, Emily A.

2017-01-01

Mathematical discussions in which students compare alternative solutions to a problem can be powerful modes for students to engage and refine their misconceptions into conceptual understanding, as well as to develop understanding of the mathematics underlying common algorithms. At the same time, these discussions are challenging to lead…
Creating 3D Physical Models to Probe Student Understanding of Macromolecular Structure

ERIC Educational Resources Information Center

Cooper, A. Kat; Oliver-Hoyo, M. T.

2017-01-01

The high degree of complexity of macromolecular structure is extremely difficult for students to process. Students struggle to translate the simplified two-dimensional representations commonly used in biochemistry instruction to three-dimensional aspects crucial in understanding structure-property relationships. We designed four different physical…
The shared landscape: what does aesthetics have to do with ecology?

Treesearch

Paul H. Gobster; Joan I. Nassauer; Terry C. Daniel; Gary Fry

2007-01-01

This collaborative essay grows out of a debate about the relationship between aesthetics and ecology and the possibility of an "ecological aesthetic" that affects landscape planning, design, and management. We describe our common understandings and unresolved questions about this relationship, including the importance of aesthetics in understanding and...
Visuals and Visualisation of Human Body Systems

ERIC Educational Resources Information Center

Mathai, Sindhu; Ramadas, Jayashree

2009-01-01

This paper explores the role of diagrams and text in middle school students' understanding and visualisation of human body systems. We develop a common framework based on structure and function to assess students' responses across diagram and verbal modes. Visualisation is defined in terms of understanding transformations on structure and relating…
Using Concept Maps to Show "Connections" in Measurement: An Example from the Australian Curriculum

ERIC Educational Resources Information Center

Marshman, Margaret

2014-01-01

Within the "Australian Curriculum: Mathematics" the Understanding proficiency strand states, "Students build understanding when they connect related ideas, when they represent concepts in different ways, when they identify commonalities and differences between aspects of content, when they describe their thinking mathematically and…
Intuitive Analysis of Variance-- A Formative Assessment Approach

ERIC Educational Resources Information Center

Trumpower, David

2013-01-01

This article describes an assessment activity that can show students how much they intuitively understand about statistics, but also alert them to common misunderstandings. How the activity can be used formatively to help improve students' conceptual understanding of analysis of variance is discussed. (Contains 1 figure and 1 table.)
Molecular understanding of lung cancers-A review

PubMed Central

Singh, Chinnappan Ravinder; Kathiresan, Kandasamy

2014-01-01

Lung cancer is considered to be the most common cancer in the world. The purpose of this paper is to review scientific evidence, particularly epidemiologic evidence of overall lung cancer burden in the world. And molecular understanding of lung cancer at various levels by dominant and suppressor oncogenes. PMID:25183110

Academic Social Cohesion within Higher Education

ERIC Educational Resources Information Center

Heuser, Brian L.

2007-01-01

This article explores the theoretical foundations of "social cohesion" as it relates to higher education institutions. In so doing it seeks (a) to understand the core elements of social cohesion--social capital, human capital and ethical behavioral norms that serve a common good--and (b) to establish a flexible framework for understanding the…
Student Teacher Understanding of the Greenhouse Effect, Ozone Layer Depletion, and Acid Rain.

ERIC Educational Resources Information Center

Dove, Jane

1996-01-01

Describes the results of a survey designed to ascertain details of student teachers' knowledge and misconceptions about the greenhouse effect, acid rain, and ozone layer depletion. Results indicate familiarity with the issues but little understanding of the concepts involved and many commonly held misconceptions. (JRH)
A mechanistic understanding of tree responses to hinning and fertilization from stable isotopes in tree rings

EPA Science Inventory

Carbon sequestration has focused renewed interest in understanding how forest management affects forest carbon gain over timescales of decades. Two of the most common forest management tools are thinning and fertilization, and yet details on physiological responses to these tools...
Darwin and Mendel: Evolution and Genetics

ERIC Educational Resources Information Center

Bizzo, Nelio; El-Hani, Charbel N.

2009-01-01

Many studies have shown that students' understanding of evolution is low and some sort of historical approach would be necessary in order to allow students to understand the theory of evolution. It is common to present Mendelian genetics to high school students prior to Biological Evolution, having in mind historical and epistemological…
Expanding the Understanding of Evolution

ERIC Educational Resources Information Center

Musante, Susan

2011-01-01

Originally designed for K-12 teachers, the Understanding Evolution (UE) Web site ("www.understandingevolution.org") is a one-stop shop for all of a teacher's evolution education needs, with lesson plans, teaching tips, lists of common evolution misconceptions, and much more. However, during the past five years, the UE project team learned that…
75 FR 52951 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

.... Toxicity from acetaminophen has been on the rise in the past 3 decades, and is now the most common cause of... proposed information collection project: ``Understanding Patients' Knowledge and Use of Acetaminophen...: Proposed Project Understanding Patients' Knowledge and Use of Acetaminophen--Phase 2 AHRQ proposes a cross...
75 FR 67372 - Agency Information Collection Activities: Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

.... Toxicity from acetaminophen has been on the rise in the past 3 decades, and is now the most common cause of... proposed information collection project: ``Understanding Patients' Knowledge and Use of Acetaminophen...: Proposed Project Understanding Patients' Knowledge and Use of Acetaminophen--Phase 2 AHRQ proposes a cross...
Evolution of reproductive proteins from animals and plants.

PubMed

Clark, Nathaniel L; Aagaard, Jan E; Swanson, Willie J

2006-01-01

Sexual reproduction is a fundamental biological process common among eukaryotes. Because of the significance of reproductive proteins to fitness, the diversity and rapid divergence of proteins acting at many stages of reproduction is surprising and suggests a role of adaptive diversification in reproductive protein evolution. Here we review the evolution of reproductive proteins acting at different stages of reproduction among animals and plants, emphasizing common patterns. Although we are just beginning to understand these patterns, by making comparisons among stages of reproduction for diverse organisms we can begin to understand the selective forces driving reproductive protein diversity and the functional consequences of reproductive protein evolution.
Beyond attributions: Understanding public stigma of mental illness with the common sense model.

PubMed

Mak, Winnie W S; Chong, Eddie S K; Wong, Celia C Y

2014-03-01

The present study applied the common sense model (i.e., cause, controllability, timeline, consequences, and illness coherence) to understand public attitudes toward mental illness and help-seeking intention and to examine the mediating role of perceived controllability between causal attributions with public attitudes and help seeking. Based on a randomized household sample of 941 Chinese community adults in Hong Kong, results of the structural equation modeling demonstrated that people who endorsed cultural lay beliefs tended to perceive the course of mental illness as less controllable, whereas those with psychosocial attributions see its course as more controllable. The more people perceived the course of mental illness as less controllable, more chronic, and incomprehensible, the lower was their acceptance and the greater was mental illness stigma. Furthermore, those who perceived mental illness with dire consequences were more likely to feel greater stigma and social distance. Conversely, when people were more accepting, they were more likely to seek help for psychological services and felt a shorter social distance. The common sense model provides a multidimensional framework in understanding public's mental illness perceptions and stigma. Not only should biopsychosocial determinants of mental illness be advocated to the public, cultural myths toward mental illness must be debunked.
Knowledge and practices related to plague in an endemic area of Uganda.

PubMed

Kugeler, Kiersten J; Apangu, Titus; Forrester, Joseph D; Griffith, Kevin S; Candini, Gordian; Abaru, Janet; Okoth, Jimmy F; Apio, Harriet; Ezama, Geoffrey; Okello, Robert; Brett, Meghan; Mead, Paul

2017-11-01

Plague is a virulent zoonosis reported most commonly from Sub-Saharan Africa. Early treatment with antibiotics is important to prevent mortality. Understanding knowledge gaps and common behaviors informs the development of educational efforts to reduce plague mortality. A multi-stage cluster-sampled survey of 420 households was conducted in the plague-endemic West Nile region of Uganda to assess knowledge of symptoms and causes of plague and health care-seeking practices. Most (84%) respondents were able to correctly describe plague symptoms; approximately 75% linked plague with fleas and dead rats. Most respondents indicated that they would seek health care at a clinic for possible plague; however plague-like symptoms were reportedly common, and in practice, persons sought care for those symptoms at a health clinic infrequently. Persons in the plague-endemic region of Uganda have a high level of understanding of plague, yet topics for targeted educational messages are apparent. Published by Elsevier Ltd.
Sleep and circadian rhythm disruption in neuropsychiatric illness.

PubMed

Jagannath, Aarti; Peirson, Stuart N; Foster, Russell G

2013-10-01

Sleep and circadian rhythm disruption (SCRD) is a common feature in many neuropsychiatric diseases including schizophrenia, bipolar disorder and depression. Although the precise mechanisms remain unclear, recent evidence suggests that this comorbidity is not simply a product of medication or an absence of social routine, but instead reflects commonly affected underlying pathways and mechanisms. For example, several genes intimately involved in the generation and regulation of circadian rhythms and sleep have been linked to psychiatric illness. Further, several genes linked to mental illness have recently been shown to also play a role in normal sleep and circadian behaviour. Here we describe some of the emerging common mechanisms that link circadian rhythms, sleep and SCRD in severe mental illnesses. A deeper understanding of these links will provide not only a greater understanding of disease mechanisms, but also holds the promise of novel avenues for therapeutic intervention. Copyright © 2013. Published by Elsevier Ltd.
Skin damage associated with intravenous therapy: common problems and strategies for prevention.

PubMed

Thayer, Debra

2012-01-01

Infusion therapy is among the most common health care interventions, with approximately 90% of hospitalized patients receiving vascular access and an estimated 1.3 million home infusion therapies delivered annually. Whereas most individuals complete their therapy uneventfully, others experience alterations in skin integrity, some significant enough to disrupt therapy. There are limited published data on the incidence of skin damage associated with infusion therapy, and the etiology of damage has not been previously described in detail. Wound, ostomy, and continence (WOC) nurses have developed a significant understanding of skin-related problems and effective prevention strategies from over 40 years of experience with ostomy patients--another population in which adhesive wear is a constant and localized, superficial skin damage is common. This article will offer a WOC nursing perspective of skin damage and seek to provide a context for understanding and preventing skin damage in the infusion therapy patient.
Understanding Children with Asthma: Trouble and Triggers

ERIC Educational Resources Information Center

Lim, JungHa; Wood, Beatrice L.; Cheah, PoAnn

2009-01-01

Asthma is one of the most common illnesses of childhood; in the United States, nearly 9% of children have the condition (Federal Interagency Forum on Child and Family Statistics, 2006). Among children with chronic illnesses, asthma is the most common cause for school absence and hospitalization (Akinbami, 2006). Asthma is a chronic disorder of the…
Global Conceptualization of the Professional Learning Community Process: Transitioning from Country Perspectives to International Commonalities

ERIC Educational Resources Information Center

Huffman, Jane B.; Olivier, Dianne F.; Wang, Ting; Chen, Peiying; Hairon, Salleh; Pang, Nicholas

2016-01-01

The authors seek to find common PLC structures and actions among global educational systems to enhance understanding and practice. Six international researchers formed the Global Professional Learning Community Network (GloPLCNet), conducted literature reviews of each country's involvement with PLC actions, and noted similarities and common…
Addressing the Standards for Mathematical Practice in a Calculus Class

ERIC Educational Resources Information Center

Pilgrim, Mary E.

2014-01-01

The Common Core State Standards (CCSS) provide teachers with the expectations and requirements that are meant to prepare K-12 students for college and the workforce (CCSSI 2010b). The Common Core State Standards for Mathematical Practice (SMPs) emphasize the development of skills and conceptual understanding for students to become proficient in…
Poststroke Depression: Social Workers' Role in Addressing an Underrecognized Psychological Problem for Couples Who Have Experienced Stroke

ERIC Educational Resources Information Center

McCarthy, Michael J.; Powers, Laurie E.; Lyons, Karen S.

2011-01-01

Depression is the most common psychological challenge faced by many individuals and families following stroke. Fortunately, poststroke depression is treatable, and even preventable, if social work and other rehabilitation practitioners understand the most common risk factors and become familiar with measures for assessing for depression among…
Federal Overreach and Common Core. White Paper No. 133

ERIC Educational Resources Information Center

Evers, Williamson M.

2015-01-01

This report provides the historical background and interpretive analysis needed to understand controversies surrounding Common Core and its associated tests. In this report, Williamson M. Evers presents a revised and expanded version of his expert report for "Jindal v. United States Department of Education et al.," No. 14-CV- 534 (M.D.…
A Cognitive Core for Common State Standards

ERIC Educational Resources Information Center

Norton, Anderson; Boyce, Steven

2013-01-01

The purpose of this paper is to illustrate cognitive challenges introduced by Common Core State Standards for Mathematics (2010) with regard to conceptualizing fractions. We focus on a strand of standards that appear across grades three through five, which is best represented in grade four, by standard 4.NF.4a: "[Students should] understand a…
Understanding and Accommodating Online Social Communities: A Common Sense Approach

ERIC Educational Resources Information Center

Lennon, Sean M.

2013-01-01

Online social networks such as Facebook have changed the context and definitions of socialization. Focusing on teacher use, this article considers the size and impact of these forums and the importance many young professionals feel toward them. Themed as a common sense approach, the author uses anecdotal points and discussions with…
Common Ground of Two Paradigms: Incorporating Critical Theory into Current Art Therapy Practices

ERIC Educational Resources Information Center

Nolan, Emily

2013-01-01

Clinical art therapy and studio-based community art therapy represent two major paradigms in art therapy practice. This viewpoint explores how critical theory can be incorporated into both paradigms and result in common ground between them. Critical theory encompasses an understanding of oppression in psychological, social, and cultural contexts…

The Energy Crisis in the Public Schools; Alternative Solutions.

ERIC Educational Resources Information Center

Grossbach, Wilmar; Shaffer, William

One hundred and eighty school personnel held a workshop with representatives of the petroleum, natural gas, and electrical power industries. The objectives of the workshop were (1) to provide participants with a common body of knowledge and a common understanding of the energy crisis and its implications for the public schools, (2) to delineate…
Precipitation in the Solar System

ERIC Educational Resources Information Center

McIntosh, Gordon

2007-01-01

As an astronomy instructor, I am always looking for commonly observed Earthly experiences to help my students and me understand and appreciate similar occurrences elsewhere in the solar system. Recently I wrote a short TPT article on frost. This paper is on the related phenomena of precipitation. Precipitation, so common on most of the Earth's…
Third Grade Written Narratives: A Cross-Linguistic Study.

ERIC Educational Resources Information Center

Gregory, George Ann

A study examined what a third grader might understand about composing a common genre like the narrative, given the degree of variance among approaches and experience. Data were collected from different school sites over a period of several years. These sites shared common geographical areas: three schools were located in the Sonoran desert shared…
Understanding Cybercrime: A Phenomenological Study

ERIC Educational Resources Information Center

Sine, Lori M.

2010-01-01

Research done over the last 15 years has promoted the need for a concise, common definition of cybercrime. Hardesty and Ball (NW3C, 1996) contended that once a universal definition was agreed upon, common procedures for investigation could be established. Cybercrime training is also essential in the investigation of this type of crime. This…
Common Standards Ignite Debate over Student "Prereading" Exercises

ERIC Educational Resources Information Center

Gewertz, Catherine

2012-01-01

Sparked by the Common Core State Standards, teachers and literacy experts are arguing about the role of a time-honored pillar of English/language arts instruction: classroom activities designed to help students understand what they are about to read. The attacks on--and defenses of--"prereading" are unfolding largely in cyberspace, through online…
The cutaneous manifestations and common mimickers of physical child abuse.

PubMed

Mudd, Shawna S; Findlay, Jeanne S

2004-01-01

The cutaneous manifestations of physical child abuse are some of the most common and easily recognized forms of injury. To make an accurate assessment and diagnosis, it is important to differentiate between inflicted cutaneous injuries and mimickers of physical abuse. Likewise, an understanding of reporting guidelines helps guide practitioners in their decision making.
Queering Constructs: Proposing a Dynamic Gender and Sexuality Model

ERIC Educational Resources Information Center

Jourian, T. J.

2015-01-01

Higher education educators commonly understand social identities, including gender, to be fluid and dynamic. Lev's (2004) model of four components of sexual identity is commonly used to demonstrate the fluidity of sex, gender, and sexuality for individuals, but it does little to address the fixedness of those constructs. Through a multipronged…
An Alternative Route to Teaching Fraction Division: Abstraction of Common Denominator Algorithm

ERIC Educational Resources Information Center

Zembat, Ismail Özgür

2015-01-01

From a curricular stand point, the traditional invert and multiply algorithm for division of fractions provides few affordances for linking to a rich understanding of fractions. On the other hand, an alternative algorithm, called common denominator algorithm, has many such affordances. The current study serves as an argument for shifting…
Public Conceptions of Algorithms and Representations in the Common Core State Standards for Mathematics

ERIC Educational Resources Information Center

Nanna, Robert J.

2016-01-01

Algorithms and representations have been an important aspect of the work of mathematics, especially for understanding concepts and communicating ideas about concepts and mathematical relationships. They have played a key role in various mathematics standards documents, including the Common Core State Standards for Mathematics. However, there have…
Helping Children Become More Knowledgeable through Text

ERIC Educational Resources Information Center

Neuman, Susan B.; Roskos, Kathleen

2012-01-01

With the adoption of the Common Core State Standards, curriculum resources are shifting from an emphasis on literary texts to a greater focus on informational texts. Although we need to understand the intention of these new Common Core State Standards, and the important drive toward greater content knowledge for all students, we must be wary of…
Common Factors of High Performance Teams

ERIC Educational Resources Information Center

Jackson, Bruce; Madsen, Susan R.

2005-01-01

Utilization of work teams is now wide spread in all types of organizations throughout the world. However, an understanding of the important factors common to high performance teams is rare. The purpose of this content analysis is to explore the literature and propose findings related to high performance teams. These include definition and types,…
The Execution and Evaluation of an Integrated Business Common Core Curriculum.

ERIC Educational Resources Information Center

Pharr, Steven W.; Morris, John S.; Stover, Dana; Byers, C. Randall; Reyes, Mario G.

1998-01-01

Describes the rationale, process, and organization of an integrated, cross-disciplinary undergraduate program known as the Integrated Business Common Core (IBC) at the University of Idaho. Indicates that IBC's goal is to provide students with an understanding of key business issues, with emphasis on processes. (2 tables and 11 references) (JDI)
Making the Common Core Text Exemplars Accessible to Middle Graders

ERIC Educational Resources Information Center

Moss, Barbara, Ed.

2013-01-01

This column provides an overview of the Common Core text exemplars and gives examples of ways teachers can group text exemplars and other trade books in ways that will support middle graders' understanding of complex texts. Building background by supplementing text exemplars with other titles is particularly emphasized. Suggestions for grouping…
How ASCD Supports the Common Core

ERIC Educational Resources Information Center

Mercado, Efrain; Britt, Sherida

2013-01-01

As the Common Core State Standards Initiative moved from the development and adoption of the standards to their implementation, ASCD embarked on a multifaceted program to help educators understand and implement the new standards. With support from a $3 million grant from the Bill and Melinda Gates Foundation, ASCD has enacted a three-pronged…
Rx for OTC Users: Improved Health Education.

ERIC Educational Resources Information Center

Shands, Virginia P.; And Others

A self-administered survey was given to 152 college students to test their knowledge and understanding of some basic health facts and terminology commonly found in printed materials affixed to or accompanying common over-the-counter (OTC) drug preparations. The results indicated that 96% of the sample had used OTC medications as college students.…
Sex Differences in Common Sports Injuries.

PubMed

Lin, Cindy; Casey, Ellen; Herman, Daniel; Katz, Nicole; Tenforde, Adam

2018-03-14

Common sports injuries include bone stress injuries (BSIs), anterior cruciate ligament (ACL) injuries, and concussions. Less commonly recognized are the specific sex differences in epidemiology, risk factors, and outcomes of these conditions by sex. An understanding of these factors can improve their clinical management, from prescribing appropriate prehabilitation to guiding postinjury rehabilitation and return to play. This narrative review summarizes the sex differences in the diagnosis and management of BSIs, ACL injuries, and concussions. Although BSIs are more common in female athletes, risk factors for both sexes include prior injury and relative energy deficiency in sport (RED-S). Risk factors in female athletes include smaller calf girth, femoral adduction, and higher rates of loading. Female athletes are also at greater risk for developing ACL injuries in high school and college, but their injury rate is similar in professional sports. Increased lateral tibial slope, smaller ACL size, and suboptimal landing mechanics are additional risk factors more often present in female athletes. Male athletes are more likely to have ACL surgery and have a higher rate of return to sport. Concussions occur more commonly in female athletes; however, female athletes are also more likely to report concussions. Male athletes more commonly sustain concussion through contact with another player. Female athletes more commonly sustain injury from contact with playing equipment. Managing post-concussion symptoms is important, and female athletes may have prolonged symptoms. An understanding of the sex-specific differences in these common sports injuries can help optimize their prehabilitation and rehabilitation. Copyright © 2018 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.
A next generation multiscale view of inborn errors of metabolism

PubMed Central

Argmann, Carmen A.; Houten, Sander M.; Zhu, Jun; Schadt, Eric E.

2015-01-01

Inborn errors of metabolism (IEM) are not unlike common diseases. They often present as a spectrum of disease phenotypes that correlates poorly with the severity of the disease-causing mutations. This greatly impacts patient care and reveals fundamental gaps in our knowledge of disease modifying biology. Systems biology approaches that integrate multi-omics data into molecular networks have significantly improved our understanding of complex diseases. Similar approaches to study IEM are rare despite their complex nature. We highlight that existing common disease-derived datasets and networks can be repurposed to generate novel mechanistic insight in IEM and potentially identify candidate modifiers. While understanding disease pathophysiology will advance the IEM field, the ultimate goal should be to understand per individual how their phenotype emerges given their primary mutation on the background of their whole genome, not unlike personalized medicine. We foresee that panomics and network strategies combined with recent experimental innovations will facilitate this. PMID:26712461
Pathways to psychosis in cannabis abuse.

PubMed

Shrivastava, Amresh; Johnston, Megan; Terpstra, Kristen; Bureau, Yves

2015-04-01

Cannabis has been implicated as a risk factor for the development of schizophrenia, but the exact biological mechanisms remain unclear. In this review, we attempt to understand the neurobiological pathways that link cannabis use to schizophrenia. This has been an area of great debate; despite similarities between cannabis users and schizophrenia patients, the evidence is not sufficient to establish cause-and-effect. There have been advances in the understanding of the mechanisms of cannabis dependence as well as the role of the cannabinoid system in the development of psychosis and schizophrenia. The neurobiological mechanisms associated with the development of psychosis and effects from cannabis use may be similar but remain elusive. In order to better understand these associations, this paper will show common neurobiological and neuroanatomical changes as well as common cognitive dysfunction in cannabis users and patients of schizophrenia. We conclude that epidemiologic evidence highlights potential causal links; however, neurobiological evidence for causality remains weak.
People Use their Knowledge of Common Events to Understand Language, and Do So as Quickly as Possible

PubMed Central

McRae, Ken; Matsuki, Kazunaga

2011-01-01

People possess a great deal of knowledge about how the world works, and it is undoubtedly true that adults use this knowledge when understanding and producing language. However, psycholinguistic theories differ regarding whether this extra-linguistic pragmatic knowledge can be activated and used immediately, or only after a delay. The authors present research that investigates whether people immediately use their generalized knowledge of common events when understanding language. This research demonstrates that (i) individual isolated words immediately activate event-based knowledge; (ii) combinations of words in sentences immediately constrain people’s event-based expectations for concepts that are upcoming in language; (iii) syntax modulates people’s expectations for ensuing concepts; and (iv) event-based knowledge can produce expectations for ensuing syntactic structures. It is concluded that theories of sentence comprehension must allow for the rapid dynamic interplay among these sources of information. PMID:22125574
Gene Ontology: Pitfalls, Biases, and Remedies.

PubMed

Gaudet, Pascale; Dessimoz, Christophe

2017-01-01

The Gene Ontology (GO) is a formidable resource, but there are several considerations about it that are essential to understand the data and interpret it correctly. The GO is sufficiently simple that it can be used without deep understanding of its structure or how it is developed, which is both a strength and a weakness. In this chapter, we discuss some common misinterpretations of the ontology and the annotations. A better understanding of the pitfalls and the biases in the GO should help users make the most of this very rich resource. We also review some of the misconceptions and misleading assumptions commonly made about GO, including the effect of data incompleteness, the importance of annotation qualifiers, and the transitivity or lack thereof associated with different ontology relations. We also discuss several biases that can confound aggregate analyses such as gene enrichment analyses. For each of these pitfalls and biases, we suggest remedies and best practices.

Psychopathy: Developmental Perspectives and their Implications for Treatment

PubMed Central

Anderson, Nathaniel E.; Kiehl, Kent A.

2015-01-01

Psychopathy is a neuropsychiatric disorder marked by deficient emotional responses, lack of empathy, and poor behavioral controls, commonly resulting in persistent antisocial deviance and criminal behavior. Accumulating research suggests that psychopathy follows a developmental trajectory with strong genetic influences, and which precipitates deleterious effects on widespread functional networks, particularly within paralimbic regions of the brain. While traditional therapeutic interventions commonly administered in prisons and forensic institutions have been notoriously ineffective at combating these outcomes, alternative strategies informed by an understanding of these specific neuropsychological obstacles to healthy development, and which target younger individuals with nascent symptoms of psychopathy are more promising. Here we review recent neuropsychiatric and neuroimaging literature that informs our understanding of the brain systems compromised in psychopathy, and apply these data to a broader understanding of its developmental course, ultimately promoting more proactive intervention strategies profiting from adaptive neuroplasticity in youth. PMID:23542910
Hospitalized for fever? Understanding hospitalization for common illnesses among insured women in a low-income setting.

PubMed

Sinha, Tara; Desai, Sapna; Mahal, Ajay

2014-07-01

Health microinsurance is a financial tool that increases utilization of health care services among low-income persons. There is limited understanding of the illnesses for which insured persons are hospitalized. Analysis of health claims at VimoSEWA, an Indian microinsurance scheme, shows that a significant proportion of hospitalization among insured adult women is for common illnesses—fever, diarrhoea and malaria—that are amenable to outpatient treatment. This study aims to understand the factors that result in hospitalization for common illnesses. The article uses a mixed methods approach. Quantitative data were collected from a household survey of 816 urban low-income households in Gujarat, India. The qualitative data are based on 10 in-depth case studies of insured women hospitalized for common illnesses and interviews with five providers. Quantitative and qualitative data were supplemented with data from the insurance scheme’s administrative records. Socioeconomic characteristics and morbidity patterns among insured and uninsured women were similar with fever the most commonly reported illness. While fever was the leading cause for hospitalization among insured women, no uninsured women were hospitalized for fever. Qualitative investigation indicates that 9 of 10 hospitalized women first sought outpatient treatment. Precipitating factors for hospitalization were either the persistence or worsening of symptoms. Factors that facilitated hospitalization included having insurance and the perceptions of doctors regarding the need for hospitalization. In the absence of quality primary care, health insurance can lead to hospitalization for non-serious illnesses. Deterrents to hospitalization point away from member moral hazard; provider moral hazard cannot be ruled out. This study underscores the need for quality primary health care and its better integration with health microinsurance schemes.
Cross-Grade Comparison of Students' Conceptual Understanding with Lenses in Geometric Optics

ERIC Educational Resources Information Center

Tural, G.

2015-01-01

Students commonly find the field of physics difficult. Therefore, they generally have learning problems. One of the subjects with which they have difficulties is optics within a physics discipline. This study aims to determine students' conceptual understanding levels at different education levels relating to lenses in geometric optics. A…
The Elusiveness of Equity: Evolution of Instructional Rounds in a Superintendent's Network

ERIC Educational Resources Information Center

Roegman, Rachel; Allen, David; Hatch, Thomas

2017-01-01

The practice of instructional rounds is a recent innovation in educational administration, intended to support administrators' understanding of instruction through the development of common language. This longitudinal study examines the rounds practice of a network of superintendents over 6 years to understand how rounds serves as a vehicle for…
Transforming Energy Instruction in Middle School to Support Integrated Understanding and Future Learning

ERIC Educational Resources Information Center

Nordine, Jeffrey; Krajcik, Joseph; Fortus, David

2011-01-01

Energy is a fundamental unifying concept of science, yet common approaches to energy instruction in middle school have shown little success with helping students develop their naive ideas about energy into more sophisticated understandings that are useful for making sense of their experiences. While traditional energy instruction often focuses on…
Common Themes in Teaching Reading for Understanding: Lessons from Three Projects

ERIC Educational Resources Information Center

Goldman, Susan R.; Snow, Catherine; Vaughn, Sharon

2016-01-01

This article reflects a metaview of the work of the three research projects funded through the Institute for Education Sciences under the Reading for Understanding competition that addressed middle-grade through high school readers (grades 4-12). All three projects shared the assumption that instruction is necessary for successful reading to learn…
Promoting the Understanding of Mathematics in Physics at Secondary Level

ERIC Educational Resources Information Center

Thompson, Alaric

2016-01-01

This article explores some of the common mathematical difficulties that 11- to 16-year-old students experience with respect to their learning of physics. The definition of "understanding" expressed in the article is in the sense of transferability of mathematical skills from topic to topic within physics as well as between the separate…
Developing Preservice Teachers' Understanding of Function Using a Vending Machine Metaphor Applet

ERIC Educational Resources Information Center

McCulloch, Allison; Lovett, Jennifer; Edgington, Cyndi

2017-01-01

The purpose of this study is to examine the use of a Vending Machine applet as a cognitive root for the development of preservice teachers understanding of function. The applet was designed to purposefully problematize common misconceptions associated with the algebraic nature of typical function machines. Findings indicated affordances and…
Understanding Listening Competency: A Systematic Review of Research Scales

ERIC Educational Resources Information Center

Fontana, Peter C.; Cohen, Steven D.; Wolvin, Andrew D.

2015-01-01

To better understand what constitutes listening competency, we perform a systematic review of listening scales. Our goal was twofold: to determine the most commonly appearing listening traits and to determine if listening scales are similar to one other. As part of our analysis, we identified 53 relevant scales and analyzed the scales…
How the Television Show "Mythbusters" Communicates the Scientific Method

ERIC Educational Resources Information Center

Zavrel, Erik; Sharpsteen, Eric

2016-01-01

The importance of understanding and internalizing the scientific method can hardly be exaggerated. Unfortunately, it is all too common for high school--and even university--students to graduate with only a partial or oversimplified understanding of what the scientific method is and how to actually employ it. Help in remedying this situation may…
The Metadiscourse Component: Understanding Writing about Reading Directives.

ERIC Educational Resources Information Center

Crismore, Avon

One of the most important functions for metadiscourse (reading directives) is to serve as textual relevance cues. Readers must use metadiscourse to determine the specific task or communicative context for understanding the total meaning of a text. Some of the more common types of metadiscourse include (1) hedges--words used to convey a note of…
Peer Assisted Learning in the Clinical Setting: An Activity Systems Analysis

ERIC Educational Resources Information Center

Bennett, Deirdre; O'Flynn, Siun; Kelly, Martina

2015-01-01

Peer assisted learning (PAL) is a common feature of medical education. Understanding of PAL has been based on processes and outcomes in controlled settings, such as clinical skills labs. PAL in the clinical setting, a complex learning environment, requires fresh evaluation. Socio-cultural theory is proposed as a means to understand educational…
Health Instruction Packages: Consumer--Understanding Your Condition.

ERIC Educational Resources Information Center

Kidd, Audrey E.; And Others

Text, illustrations, and exercises are utilized in this set of three learning modules to inform members of the general public about the causes and treatments of the common medical ailments that they may have. The first module, "Understanding Ligation of Hemorrhoids as an Office Procedure" by Audrey E. Kidd, lists the symptoms of…
Bridging Identities and Disciplines: Advances and Challenges in Understanding Multiple Identities

ERIC Educational Resources Information Center

Phinney, Jean S.

2008-01-01

The chapters in this volume address the need for a better understanding of the development of intersecting identities over age and context. The chapters provide valuable insights into the development of identities, particularly group identities. They highlight common processes across identities, such as the role of contrast and comparison and the…
Probing Student Teachers' Subject Content Knowledge in Chemistry: Case Studies Using Dynamic Computer Models

ERIC Educational Resources Information Center

Toplis, Rob

2008-01-01

This paper reports case study research into the knowledge and understanding of chemistry for six secondary science student teachers. It combines innovative student-generated computer animations, using "ChemSense" software, with interviews to probe understanding of four common chemical processes used in the secondary school curriculum. Findings…
Different Approaches to Understanding Patients in General Practice in Denmark: A Qualitative Study

ERIC Educational Resources Information Center

Davidsen, Annette Sofie; Reventlow, Susanne

2011-01-01

General practitioners (GPs) treat more than 90% of common mental disorders. Their approaches to psychological interventions have been little studied and their process of understanding patients remains unexplored. This qualitative interview and observation study aimed to explore Danish GPs' approaches to emotional problems and mental disorders in…
Clock Work: How Tools for Time Mediate Problem Solving and Reveal Understanding

ERIC Educational Resources Information Center

Earnest, Darrell

2017-01-01

This article reports on elementary students' understanding of time in the context of common classroom manipulatives and notational systems. Students in Grades 2 (n = 72) and 4 (n = 72) participated in problem-solving interviews involving different clocks. Quantitative results revealed that students' performances were significantly different as a…
Frameworks for Understanding Challenging Behaviour in Out-of-Home Care

ERIC Educational Resources Information Center

McLean, Sara; Kettler, Lisa; Delfabbro, Paul; Riggs, Damien

2012-01-01

Background: Challenging and disruptive behaviour is commonly reported among children placed in the out-of-home care sector. Little is known about how stakeholders in this sector understand or manage challenging behaviour. Method: Ninety-two stakeholders in the South Australian out-of-home care sector were interviewed about their approach to…
Using Spreadsheets to Discover Meaning for Parameters in Nonlinear Models

ERIC Educational Resources Information Center

Green, Kris H.

2008-01-01

This paper explores the use of spreadsheets to develop an exploratory environment where mathematics students can develop their own understanding of the parameters of commonly encountered families of functions: linear, logarithmic, exponential and power. The key to this understanding involves opening up the definition of rate of change from the…
Children with Autism Are Impaired in the Understanding of Teaching

ERIC Educational Resources Information Center

Knutsen, John; Mandell, David S.; Frye, Douglas

2017-01-01

Children learn novel information using various methods, and one of the most common is human pedagogical communication or teaching--the purposeful imparting of information from one person to another. Neuro-typically developing (TD) children gain the ability to recognize and understand teaching as a core method for acquiring knowledge from others.…

Mathematics, Thermodynamics, and Modeling to Address Ten Common Misconceptions about Protein Structure, Folding, and Stability

ERIC Educational Resources Information Center

Robic, Srebrenka

2010-01-01

To fully understand the roles proteins play in cellular processes, students need to grasp complex ideas about protein structure, folding, and stability. Our current understanding of these topics is based on mathematical models and experimental data. However, protein structure, folding, and stability are often introduced as descriptive, qualitative…
Sociology and a General Understanding of Social Life

ERIC Educational Resources Information Center

Wagenaar, Theodore C.; Keith, Bruce; Ender, Morten G.

2004-01-01

Beginning at the introductory level, the authors believe students ought to experience a common framework for approaching a general understanding of social life. At a minimum, this requires going back to the discipline's history--back to the journals and books that provide the foundational context for the discipline's framework and, therefore, its…
Unique and common mechanisms of change across cognitive and dynamic psychotherapies.

PubMed

Gibbons, Mary Beth Connolly; Crits-Christoph, Paul; Barber, Jacques P; Wiltsey Stirman, Shannon; Gallop, Robert; Goldstein, Lizabeth A; Temes, Christina M; Ring-Kurtz, Sarah

2009-10-01

The goal of this article was to examine theoretically important mechanisms of change in psychotherapy outcome across different types of treatment. Specifically, the role of gains in self-understanding, acquisition of compensatory skills, and improvements in views of the self were examined. A pooled study database collected at the University of Pennsylvania Center for Psychotherapy Research, which includes studies conducted from 1995 to 2002 evaluating the efficacy of cognitive and psychodynamic therapies for a variety of disorders, was used. Patient samples included major depressive disorder, generalized anxiety disorder, panic disorder, borderline personality disorder, and adolescent anxiety disorders. A common assessment battery of mechanism and outcome measures was given at treatment intake, termination, and 6-month follow-up for all 184 patients. Improvements in self-understanding, compensatory skills, and views of the self were all associated with symptom change across the diverse psychotherapies. Changes in self-understanding and compensatory skills across treatment were predictive of follow-up symptom course. Changes in self-understanding demonstrated specificity of change to dynamic psychotherapy. (c) 2009 APA, all rights reserved.
Hermeneutic application research - finding a common understanding and consensus on care and caring.

PubMed

Koskinen, Camilla; Nyström, Lisbet

2017-03-01

To clinically and contextually implement the theoretical and factual knowledge of care and caring that has been developed in the last 30 years is seen as a great challenge in caring science research. Emphasis has been put on problem-solving research methodologies and action research in hopes of narrowing the divide between caring theory and clinical practice. Thus, the intention is now to further action research towards a hermeneutic approach and to put emphasis on hermeneutic application where theory and praxis become one through human dialogue. This article highlights hermeneutic application research as an alternative methodology within participatory-oriented research which presents a new opportunity to unite clinical practice and caring theory. The aim is to contribute to the development of the hermeneutical application research design in its epistemological, ontological and ethical perspective, by articulating and clarifying the central foundations in the application. On the basis of Gadamer's hermeneutical thinking and Levinas ethical thinking, the central foundations in the application research are ethics, creation of a hermeneutical room, dialogue and common understanding and appropriation and action. When theoretical understanding turns into praxis, knowledge also becomes activity and theory and practice become one. Application thus realises the basic idea that praxis and theory are one, and thus, theory of caring can only become evident and implemented in a clinical practice through moments when the participants find a common understanding and consensus on the knowledge of care and caring. © 2015 Nordic College of Caring Science.
A pilot study on understanding the journey of advanced prostate cancer patients.

PubMed

Wagholikar, Amol; Fung, Maggie; Nelson, Colleen

2011-01-01

To understand the journey of advanced prostate cancer patients for supporting development of an innovative patient journey browser. Prostate cancer is one of the common cancers in Australia. Due to the chronic nature of the disease, it is important to have effective disease management strategy and care model. Multi-disciplinary care is a well-proven approach for chronic disease management. The Multi-disciplinary team (MDT) can function more effectively if all the required information is available for the clinical decision support. The development of innovative technology relies on an accurate understanding of the advanced prostate cancer patient's journey over a prolonged period. This need arises from the fact that advanced prostate cancer patients may follow various treatment paths and change their care providers. As a result of this, it is difficult to understand the actual sources of patient's clinical records and their treatment patterns. The aim of the research is to understand variable sources of clinical records, treatment patterns, alternative therapies, over the counter (OTC) medications of advanced prostate cancer patients. This study provides better and holistic understanding of advanced prostate cancer journey. The study was conducted through an on-line survey developed to seek and analyse the responses from the participants. The on-line questionnaire was carefully developed through consultations with the clinical researchers at the Australian Prostate Cancer Research Centre-Queensland, prostate cancer support group representatives and health informaticians at the Australian E-Health Research Centre. The non-identifying questionnaire was distributed to the patients through prostate cancer support groups in Queensland, Australia. The pilot study was carried out between August 2010 and December 2010. The research made important observations about the advanced prostate cancer journey. It showed that General Practitioner (GP) was the common source of patient's clinical records (41%) followed by Urologist (14%) and other clinicians (14%). The data analysis also showed that selenium was the common complementary supplement (55%) used by the patients and about 48% patients did not use any OTC drugs. The most common OTC used by the patients was Paracetamol (about 45%). The results have provided a foundation to the architecture of the proposed technology solution. The outcomes of this study are incorporated in design of the proposed patient journey browser system. A basic version of the system is currently being used at the advanced prostate cancer MDT meetings.
Text mining of rheumatoid arthritis and diabetes mellitus to understand the mechanisms of Chinese medicine in different diseases with same treatment.

PubMed

Zhao, Ning; Zheng, Guang; Li, Jian; Zhao, Hong-Yan; Lu, Cheng; Jiang, Miao; Zhang, Chi; Guo, Hong-Tao; Lu, Ai-Ping

2018-01-09

To identify the commonalities between rheumatoid arthritis (RA) and diabetes mellitus (DM) to understand the mechanisms of Chinese medicine (CM) in different diseases with the same treatment. A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verifified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identifified via text mining was used as the intervention. Similarities were identifified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflfl ammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflfl ammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Commonalities between the biological activities involved in RA and DM were identifified through text mining, and both RA and DM might be responsive to the same intervention at a specifific stage.
Transcriptome analysis of two recombinant inbred lines of common bean contrasting for symbiotic nitrogen fixation

PubMed Central

Kamfwa, Kelvin; Zhao, Dongyan; Kelly, James D.

2017-01-01

Common bean (Phaseolus vulgaris L.) fixes atmospheric nitrogen (N2) through symbiotic nitrogen fixation (SNF) at levels lower than other grain legume crops. An understanding of the genes and molecular mechanisms underlying SNF will enable more effective strategies for the genetic improvement of SNF traits in common bean. In this study, transcriptome profiling was used to identify genes and molecular mechanisms underlying SNF differences between two common bean recombinant inbred lines that differed in their N-fixing abilities. Differential gene expression and functional enrichment analyses were performed on leaves, nodules and roots of the two lines when grown under N-fixing and non-fixing conditions. Receptor kinases, transmembrane transporters, and transcription factors were among the differentially expressed genes identified under N-fixing conditions, but not under non-fixing conditions. Genes up-regulated in the stronger nitrogen fixer, SA36, included those involved in molecular functions such as purine nucleoside binding, oxidoreductase and transmembrane receptor activities in nodules, and transport activity in roots. Transcription factors identified in this study are candidates for future work aimed at understanding the functional role of these genes in SNF. Information generated in this study will support the development of gene-based markers to accelerate genetic improvement of SNF in common bean. PMID:28192540
Genetics and Common Disorders: Implications for Primary Care and Public Health Providers

DOE Office of Scientific and Technical Information (OSTI.GOV)

McInerney, Joseph D.; Greendale, Karen; Peay, Holly L.

We developed this program for primary care providers (PCPs) and public health professionals (PHPs) who are interested in increasing their understanding of the genetics of common chronic diseases and of the implications of genetics and genomics for their fields. The program differs from virtually all previous educational efforts in genetics for health professionals in that it focuses on the genetics of common chronic disease and on the broad principles that emerge when one views disease from the perspectives of variation and individuality, which are at the heart of thinking genetically. The CD-ROM introduces users to content that will improve theirmore » understanding of topics such as: • A framework for genetics and common disease; • Basic information on genetics, genomics, genetic medicine, and public health genetics, all in the context of common chronic disease; • The status of research on genetic contributions to specific common diseases, including a review of research methods; • Genetic/environmental interaction as the new “central dogma” of public health genetics; • The importance of taking and analyzing a family history; • The likely impact of potential gene discovery and genetic testing on genetic counseling and risk assessment and on the practices of PCPs and PHPs; • Stratification of populations into low-, moderate-, and high-risk categories; • The potential role of PCPs and PHPs in identifying high-risk individuals and families, in providing limited genetics services, and in referring to clinical genetics specialists; the potential for standard referral algorithms; • Implications of genetic insights for diagnosis and treatment; • Ethical, legal, and social issues that arise from genetic testing for common chronic diseases; and • Specific prevention strategies based on understanding of genetics and genetic/ environmental interactions. The interactive content – developed by experts in genetics, primary care, and public health – is organized around two case studies designed to appeal to primary care providers (thrombophilia) and public health professionals (development of a screening grogram for colorectal cancer). NCHPEG has distributed more than 0000 copies of the CD-ROM to NCHPEG member organizations and to other organizations and individuals in response to requests. The program also is available at www.nchpeg.org.« less
Text and Truth: Reading, Student Experience, and the Common Core

ERIC Educational Resources Information Center

Sandler, Susan; Hammond, Zaretta

2012-01-01

One of the rumors making the rounds of K-12 educators goes something like this: The Common Core State Standards do not allow "prereading"--the pedagogical practice meant to help students better understand a text they are about to read--or for that matter any classroom activities that contextualize a text through outside sources. The interesting…
Reaching Future Scientists, Consumers, & Citizens: What Do Secondary School Textbooks Say about Genomics & Its Impact on Health?

ERIC Educational Resources Information Center

Hicks, Melissa A.; Cline, Rebecca J.; Trepanier, Angela M.

2014-01-01

An understanding of how genomics information, including information about risk for common, multifactorial disease, can be used to promote personal health (personalized medicine) is becoming increasingly important for the American public. We undertook a quantitative content analysis of commonly used high school textbooks to assess how frequently…
The Responsibilities of the Scientist in International Understanding, Co-Operation, Peace, and Human Rights.

ERIC Educational Resources Information Center

Voinea, Radu; Pascu, Ioan Mircea

1984-01-01

A discussion of the responsibility of scientists as repositories of knowledge, as educators, and as citizens outlines some concerns of the scientific community for problems of peace and disarmament. It is noted that a recent common awareness of a common responsibility for society is evident in the intensity of scientific contacts. (MSE)
A conceptual model for megaprogramming

NASA Technical Reports Server (NTRS)

Tracz, Will

1990-01-01

Megaprogramming is component-based software engineering and life-cycle management. Magaprogramming and its relationship to other research initiatives (common prototyping system/common prototyping language, domain specific software architectures, and software understanding) are analyzed. The desirable attributes of megaprogramming software components are identified and a software development model and resulting prototype megaprogramming system (library interconnection language extended by annotated Ada) are described.
Applying Symmetries of Common Objects to Help Students Understand Stereoselectivity for Apparently Symmetric Substrates

ERIC Educational Resources Information Center

Jittam, Piyachat; Ruenwongsa, Pintip; Panijpan, Bhinyo

2008-01-01

We have found it an effective way of teaching symmetry in the context of stereoselectivity, to use common everyday objects with the same point groups as the substrates involved. This has helped students to distinguish between those symmetry elements which allow for stereospecificity and those which preclude it. Two symmetry elements, the simple…
Reframing a Social Studies Methods Course: Preparing Elementary Teacher Candidates for the Common Core

ERIC Educational Resources Information Center

Gleeson, Ann Marie; D'Souza, Lisa Andries

2016-01-01

The emphasis on disciplinary literacy skills embedded within the Common Core State Standards requires a shift in preparing teachers to explicitly address the craft of reading and writing within social studies instruction. As teacher educators, we think it is imperative to understand the ways in which our teacher candidates integrate literacy…
"My Understanding Has Grown, My Perspective Has Switched": Linking Informal Writing to Learning Goals

ERIC Educational Resources Information Center

Hudd, Suzanne S.; Smart, Robert A.; Delohery, Andrew W.

2011-01-01

The use of informal writing is common in sociology. This article presents one model for integrating informal written work with learning goals through a theoretical framework known as concentric thinking. More commonly referred to as "the PTA model" because of the series of cognitive tasks it promotes--prioritization, translation, and analogy…
What Digital Games and Literacy Have in Common: A Heuristic for Understanding Pupils' Gaming Literacy

ERIC Educational Resources Information Center

Apperley, Thomas; Walsh, Christopher

2012-01-01

This article argues that digital games and school-based literacy practices have much more in common than is reported in the research literature. We describe the role digital game paratexts--ancillary print and multimodal texts about digital games--can play in connecting pupils' gaming literacy practices to "traditional" school-based literacies…
Crosswalk Analysis of Deeper Learning Skills to Common Core State Standards

ERIC Educational Resources Information Center

Conley, David T.

2011-01-01

The Educational Policy Improvement Center (EPIC) conducted a crosswalk between the Deeper Learning Skills (DLS) and the Common Core State Standards (CCSS). The purpose of the crosswalk was to understand the ways in which strategies for deeper learning relate to the CCSS. This comparison was not solely or simply an alignment study, although some…
Critical Multimodal Literacy and the Common Core: Subversive Curriculum in the Age of Accountability

ERIC Educational Resources Information Center

Perttula, Jill

2017-01-01

The purpose of this case study research was to understand the ways in which an innovative, urban secondary English teacher (Ms. B) approached English Language Arts, when a set, standardized curriculum and testing were in place. The Common Core standards were prescribed within a required module-based presentation format. New literacies pedagogy…
Teachers' Understanding of and Concerns about Mathematical Modeling in the Common Core Standards

ERIC Educational Resources Information Center

Wolf, Nancy Butler

2013-01-01

Educational reform is most likely to be successful when teachers are knowledgeable about the intended reform, and when their concerns about the reform are understood and addressed. The Common Core State Standards (CCSS) is an effort to establish a set of nationwide expectations for students and teachers. This study examined teacher understanding…
Understanding the Common Elements of Evidence-Based Practice: Misconceptions and Clinical Examples

ERIC Educational Resources Information Center

Chorpita, Bruce F.; Becker, Kimberly D.; Daleiden, Eric L.

2007-01-01

In this article, the authors proposed a distillation and matching model (DMM) that describes how evidence-based treatment operations can be conceptualized at a lower order level of analysis than simply by their manuals. Also referred to as the "common elements" approach, this model demonstrates the feasibility of coding and identifying the…

Teacher Concerns and the Enacted Curriculum of the Common Core State Standards in High School Mathematics

ERIC Educational Resources Information Center

Diletti, Jeri S.

2017-01-01

The Common Core State Standards for Mathematics (CCSSM) highlight the importance of students' conceptual understanding, mathematical reasoning, and problem solving in order to prepare students for college and careers. However, the success of this reform effort largely depends on how teachers actually design and implement instruction based on the…
The Threat of Common Method Variance Bias to Theory Building

ERIC Educational Resources Information Center

Reio, Thomas G., Jr.

2010-01-01

The need for more theory building scholarship remains one of the pressing issues in the field of HRD. Researchers can employ quantitative, qualitative, and/or mixed methods to support vital theory-building efforts, understanding however that each approach has its limitations. The purpose of this article is to explore common method variance bias as…
Causal Systems Categories: Differences in Novice and Expert Categorization of Causal Phenomena

ERIC Educational Resources Information Center

Rottman, Benjamin M.; Gentner, Dedre; Goldwater, Micah B.

2012-01-01

We investigated the understanding of causal systems categories--categories defined by common causal structure rather than by common domain content--among college students. We asked students who were either novices or experts in the physical sciences to sort descriptions of real-world phenomena that varied in their causal structure (e.g., negative…
How To Avoid Crossfire and Seek Common Ground: A Journey for the Sake of Children.

ERIC Educational Resources Information Center

Ledell, Marjorie

A democracy must tolerate many points of view without becoming divided. Therefore, public educators and the communities they serve are challenged to help students understand political and religious issues without proselytizing. This handbook provides guidelines for beginning the journey toward common ground, for moving from a climate of antagonism…
Elderly adults and skin disorders: common problems for nondermatologists.

PubMed

Na, Chang R; Wang, Steven; Kirsner, Robert S; Federman, Daniel G

2012-11-01

Diseases of elderly adults are becoming increasingly important as life expectancy gradually rises worldwide. To promote healthy aging, it is important to understand the skin changes associated with aging. This review focuses on the special considerations for some of the more common dermatological disorders in elderly adults and examines presentation, contributing factors, and association with systemic diseases.
Complicated Politics to the Core

ERIC Educational Resources Information Center

McGuinn, Patrick

2015-01-01

People dislike the Common Core for several different reasons, and so it is important to disaggregate the sources of opposition and to assess and then to dispel some of the myths that have built up around it. It also is important to understand the unusual political alliances that have emerged in opposition to Common Core implementation and how they…
Teachers' Perceptions of Preparedness Related to National Common Core State Standards for Mathematics

ERIC Educational Resources Information Center

Brown, Tykier

2016-01-01

With the adoption of the National Common Core State Standards in Mathematics (CCSSM) in many states and the lack of understanding and strategies to implement the new standards by classroom teachers, implementing effective professional development is vital. The focus of this qualitative case study was to provide insight into elementary school…
Impacts of Professional Development on High School Mathematics Teachers as They Implement Common Core State Standards

ERIC Educational Resources Information Center

Saucedo, Ana A.

2017-01-01

The purpose of this qualitative study was to understand the perceptions of high school mathematics teachers regarding the support provided through professional development (PD) as they engage in the implementation of the Common Core State Standards (CCSS). By means of a qualitative instrumental case study, eight high school mathematics teachers…
English Learners, Writing, and the Common Core

ERIC Educational Resources Information Center

Olson, Carol Booth; Scarcella, Robin; Matuchniak, Tina

2015-01-01

Adopted by 46 states, the Common Core State Standards (CCSS) present a vision of what it means to be literate in the twenty-first century and call for all students, including English learners, to develop critical reading skills necessary for a deep understanding of complex texts, and critical writing skills to write about those texts. This article…
Air Pollution: The Knowledge and Attitudes of Secondary School Students in Hong Kong

ERIC Educational Resources Information Center

Boyes, Edward; Stanisstreet, Martin; Yeung, Stephen Pui-ming

2004-01-01

This paper examines the knowledge and understanding of Hong Kong secondary school students about the composition of unpolluted and polluted air, and the nature and effects of air pollutants. A number of misconceptions are highlighted, including the common belief amongst younger students that oxygen was more common in unpolluted air than nitrogen.…
Common pitfalls in statistical analysis: Understanding the properties of diagnostic tests - Part 1.

PubMed

Ranganathan, Priya; Aggarwal, Rakesh

2018-01-01

In this article in our series on common pitfalls in statistical analysis, we look at some of the attributes of diagnostic tests (i.e., tests which are used to determine whether an individual does or does not have disease). The next article in this series will focus on further issues related to diagnostic tests.
Using Reference Materials: An Activity that Works

ERIC Educational Resources Information Center

Curriculum Review, 2009

2009-01-01

A common complaint of employers of entry-level workers is that those workers have no understanding of how to work as a member of a team. Cooperative learning is a step in that direction. Working together toward a common goal is an admirable quest: however, within this system the wayward student occasionally is allowed to "coast" while the…
The Unified Classification System (UCS): improving our understanding of periprosthetic fractures.

PubMed

Duncan, C P; Haddad, F S

2014-06-01

Periprosthetic fractures are an increasingly common complication following joint replacement. The principles which underpin their evaluation and treatment are common across the musculoskeletal system. The Unified Classification System proposes a rational approach to treatment, regardless of the bone that is broken or the joint involved. ©2014 The British Editorial Society of Bone & Joint Surgery.
ED breast cases and other breast emergencies.

PubMed

Khadem, Nasim; Reddy, Sravanthi; Lee, Sandy; Larsen, Linda; Walker, Daphne

2016-02-01

Patients with pathologic processes of the breast commonly present in the Emergency Department (ED). Familiarity with the imaging and management of the most common entities is essential for the radiologist. Additionally, it is important to understand the limitations of ED imaging and management in the acute setting and to recognize when referrals to a specialty breast center are necessary. The goal of this article is to review the clinical presentations, pathophysiology, imaging, and management of emergency breast cases and common breast pathology seen in the ED.
[Jaspers and the problem of understanding: a plea for revision].

PubMed

Brücher, K

2012-04-01

Understanding (Verstehen), as far as it is discussed explicitly in psychiatry, is based on Dilthey's dichotomy "nature we explain, the life of the soul we understand ( , 144). According to this doctrine, understanding is concerned with a person's inner life and consequently, its method consists in putting oneself in the other's position and reliving their experience. Jaspers' concept of understanding - which is regarded as definitive for psychiatry by advocates and opponents alike - is commonly interpreted according to this tradition as well. I shall argue here that this position does not stand up to scrutiny. It is a mistake to simplify Dilthey's concept of understanding to a form of mere psychologism. In fact, Jaspers practically tore this position down. In his own account, by contrast, he utilises Max Weber and Rickert to established a third realm in addition to a person's inner life on the one hand and their bodily nature on the other: the realm of the objective products of the human mind. It is this dimension that is essential for understanding. Such a transition from the dichotomy of explaining and understanding to a three-valued logic requires a radical rethinking of the traditional notion of understanding. Jaspers meets this demand but he does so only implicitly and not always consistently so that it might easily be missed. It is nonetheless crucial to see that Jaspers in fact rejects the hermeneutics of empathy which are commonly attributed to him and for which he is often criticised. In conclusion of this essay, I will suggest some implications of this - often overlooked - distinction for psychiatry and psychology. © Georg Thieme Verlag KG Stuttgart · New York.
Model-Based Knowing: How Do Students Ground Their Understanding About Climate Systems in Agent-Based Computer Models?

NASA Astrophysics Data System (ADS)

Markauskaite, Lina; Kelly, Nick; Jacobson, Michael J.

2017-12-01

This paper gives a grounded cognition account of model-based learning of complex scientific knowledge related to socio-scientific issues, such as climate change. It draws on the results from a study of high school students learning about the carbon cycle through computational agent-based models and investigates two questions: First, how do students ground their understanding about the phenomenon when they learn and solve problems with computer models? Second, what are common sources of mistakes in students' reasoning with computer models? Results show that students ground their understanding in computer models in five ways: direct observation, straight abstraction, generalisation, conceptualisation, and extension. Students also incorporate into their reasoning their knowledge and experiences that extend beyond phenomena represented in the models, such as attitudes about unsustainable carbon emission rates, human agency, external events, and the nature of computational models. The most common difficulties of the students relate to seeing the modelled scientific phenomenon and connecting results from the observations with other experiences and understandings about the phenomenon in the outside world. An important contribution of this study is the constructed coding scheme for establishing different ways of grounding, which helps to understand some challenges that students encounter when they learn about complex phenomena with agent-based computer models.
Understanding Work and Literacy: (E)merging Discourses at Work. Research into Practice Series Number 7.

ERIC Educational Resources Information Center

Castleton, Geraldine; Ovens, Carolyn; Ralston, Deborah

The nature and effects of current common understandings of the relationship between work and literacy were examined along with the typical design and objectives of workplace literacy programs for members of Australia's work force. Special attention was paid to the following topics: changing demands of work and literacy at work; discourses of…
11-12 Year Old Children's Informal Knowledge and Its Influence on their Formal Probabilistic Reasoning.

ERIC Educational Resources Information Center

Williams, J. S.; Amir, G. S.

This study sought to determine: (1) what children understand about "chance" when they begin secondary school?; and (2) how common and how influential the use of informal heuristics, approaches, and biases is in their thinking about probability in the school context. Children's understanding of chance, attributions of events to…
Development of Body-Part Vocabulary in Toddlers in Relation to Self-Understanding

ERIC Educational Resources Information Center

Waugh, Whitney E.; Brownell, Celia A.

2015-01-01

To better understand young children's ability to communicate about their bodies, toddlers' comprehension and production of 27 common body-part words was assessed using parental report at 20 and 30 months (n?=?64), and self-awareness was assessed using mirror self-recognition. Children at both ages comprehended more body-part words that referred to…
Return on Investment and Grants: A Review of Present Understandings and Recommendations for Change

ERIC Educational Resources Information Center

Preuss, Michael

2016-01-01

The need to understand efficacy and outcomes from grant-funded activity is common to funders, the academic community, and the public. Yet, few articles in the research administration corpus offer details on and considerations of applying the concept of return on investment (ROI) to grant activity. To determine the volume of material available…

Teaching with External Representations: The Case of a Common Energy-Level Diagram in Chemistry

ERIC Educational Resources Information Center

Orgill, MaryKay; Crippen, Kent

2010-01-01

Diagrams and figures play a central role in science and science education. Research has indicated that, when presented and used properly in a classroom setting, these external representations can contribute to students' understanding of scientific concepts; however, it is apparent that students do not always use, understand, interpret, or value…
Evaluating the Effectiveness of Organic Chemistry Textbooks in Promoting Representational Fluency and Understanding of 2D-3D Diagrammatic Relationships

ERIC Educational Resources Information Center

Kumi, Bryna C.; Olimpo, Jeffrey T.; Bartlett, Felicia; Dixon, Bonnie L.

2013-01-01

The use of two-dimensional (2D) representations to communicate and reason about micromolecular phenomena is common practice in chemistry. While experts are adept at using such representations, research suggests that novices often exhibit great difficulty in understanding, manipulating, and translating between various representational forms. When…
"Girls Are Worse": Drama Queens, Ghetto Girls, Tomboys, and the Meaning of Girl Fights

ERIC Educational Resources Information Center

Waldron, Linda M.

2011-01-01

This article uses a race-class-gender intersectional approach to analyze qualitative interviews with girls at two public high schools to better understand a common perception that "girls are worse" when it comes to school fights. Several different understandings of why girls fight emerged from the data. On one hand, girls' perception of…
Injury and Inclusion: Understanding Common Legal Concerns in Physical Education

ERIC Educational Resources Information Center

McCoy, Lauren; Esslinger, Keri; Baghurst, Timothy

2017-01-01

Physical education teachers are often focused on the many benefits of physical education to students, but there must also be a consideration of risk. How can the risks in physical education be minimized to maximize the benefits? One way to accomplish this goal is to increase physical educators' understanding of the legal risks related to…
Code Switching among Bilingual and Limited English Proficient Students: Possible Indicators of Giftedness

ERIC Educational Resources Information Center

Hughes, Claire E.; Shaunessy, Elizabeth S.; Brice, Alejandro R.; Ratliff, Mary Anne; McHatton, Patricia Alvarez

2006-01-01

Code switching includes the use of complete sentences, phrases, and borrowed words from another language (Brice & Brice, 2000). It is a common linguistic phenomenon noted among bilingual populations. In order to code switch effectively, students must possess a high level of understanding of the 2 cultures, as well as a deep understanding of the…
Teaching Multiplication with Regrouping Using the Concrete-Representational-Abstract Sequence and the Strategic Instruction Model

ERIC Educational Resources Information Center

Flores, Margaret M.; Franklin, Toni M.

2014-01-01

The Common Core State Standards (2010) involve the demonstration of conceptual knowledge of numbers and operations. For students who struggle with mathematics and have not responded to instruction, it is important that interventions emphasize this understanding. In order to address conceptual understanding of numbers and operations in meeting the…
Risk terminology primer: Basic principles and a glossary for the wildland fire management community

Treesearch

Matthew P. Thompson; Tom Zimmerman; Dan Mindar; Mary Taber

2016-01-01

Risk management is being increasingly promoted as an appropriate method for addressing wildland fire management challenges. However, a lack of a common understanding of risk concepts and terminology is hindering effective application. In response, this General Technical Report provides a set of clear, consistent, understandable, and usable definitions for terms...
Bridging the Gap: Fraction Understanding Is Central to Mathematics Achievement in Students from Three Different Continents

ERIC Educational Resources Information Center

Torbeyns, Joke; Schneider, Michael; Xin, Ziqiang; Siegler, Robert S.

2015-01-01

Numerical understanding and arithmetic skills are easier to acquire for whole numbers than fractions. The "integrated theory of numerical development" posits that, in addition to these differences, whole numbers and fractions also have important commonalities. In both, students need to learn how to interpret number symbols in terms of…
Gagne's DMGT 2.0: A Possible Model of Unification and Shared Understandings

ERIC Educational Resources Information Center

Bannister-Tyrrell, Michelle

2017-01-01

Gagne's (1985, 2004, 2008, 2010, 2013) Differentiated Model of Giftedness and Talent (DMGT) has evolved in response to findings from the research in cognitive and developmental psychology and neuroscience. As the DMGT is commonly used in Australia, it is important that the model reflects our understanding of intelligence, what high potential is…
Evaluating Structural Change Approaches to Health Promotion: An Exploratory Scoping Review of a Decade of U.S. Progress

ERIC Educational Resources Information Center

Asada, Yuka; Lieberman, Lisa D.; Neubauer, Leah C.; Hanneke, Rosie; Fagen, Michael C.

2018-01-01

Structural change approaches--also known as policy and environmental changes--are becoming increasingly common in health promotion, yet our understanding of how to evaluate them is still limited. An exploratory scoping review of the literature was conducted to understand approaches and methods used to evaluate structural change interventions in…
Mathematical Self-Efficacy and Understanding: Using Geographic Information Systems to Mediate Urban High School Students' Real-World Problem Solving

ERIC Educational Resources Information Center

DeBay, Dennis J.

2013-01-01

To explore student mathematical self-efficacy and understanding of graphical data, this dissertation examines students solving real-world problems in their neighborhood, mediated by professional urban planning technologies. As states and schools are working on the alignment of the Common Core State Standards for Mathematics (CCSSM), traditional…
Feeling as a Way of Knowing: A Practical Guide for Working with Emotional Experience.

ERIC Educational Resources Information Center

Artz, Sibylle

Feeling, emotion, and passion are the "stuff" of everyday experience. This guidebook helps the reader understand emotions in a two-step approach. First, common assumptions about emotion are examined in order to arrive at a deeper understanding of current approaches to emotion, especially as these exist in the fields of psychology and…
Descriptive Understandings of the Nature of Science: Examining the Consensual and Family Resemblance Approaches

ERIC Educational Resources Information Center

do Nascimento Rocha, Maristela; Gurgel, Ivã

2017-01-01

This paper performs a critical analysis of the consensual and family resemblance approaches to the nature of science. Despite the debate that surrounds them, between a pragmatic consensus and a more comprehensive understanding, both approaches have in common the goal of helping students to "internalize" knowledge about science in a…
All about Waves. Physical Science for Children[TM]. Schlessinger Science Library. [Videotape].

ERIC Educational Resources Information Center

2000

Sound. Light. Heat. Even earthquakes! They all travel in waves. Waves are a transfer of energy and understanding them allows us to better understand the world around us. Discover the two ways in which waves move, and learn about the characteristics of waves; wavelength, amplitude and frequency. Students learn about the common characteristics of…
Toward a Better Understanding of Culture: Wikis in the Beginning German Classroom

ERIC Educational Resources Information Center

Ducate, Lara; Steckenbiller, Christiane

2017-01-01

The questions of how to teach culture, which culture(s) to teach and how to lead students to intercultural competence and understanding are common questions for language teachers. The current project employed wikis to systematically integrate culture and authentic texts into beginning German courses at a large south-eastern university in the…
Getting around the Impasse: A Grounded Approach to Teaching Ethics and Social Responsibility in International Business Education.

ERIC Educational Resources Information Center

Jones, Marc T.; Lok, Peter

1999-01-01

Considers the dilemma of teaching ethics and social responsibility in international business courses with either an ethnocentric absolutist or an unengaged relativistic approach. Suggests a strategy that focuses on a grounded understanding of the elements, processes, and properties of capitalism that would serve as a common understanding upon…
Indian Education for All: Essential Understandings Regarding Montana Indians. Revised

ERIC Educational Resources Information Center

Montana Office of Public Instruction, 2010

2010-01-01

In the year 1999, OPI [Montana Office of Public Instruction] brought together representatives from all the tribes in Montana and created 7 Essential Understandings. These are some of the major issues all tribes have in common. They form the basis for all of our curriculum efforts and initiatives. There is great diversity among the 12 tribal…
Principal Leadership and Reading Specialist Role Understanding in the Era of Test-Based Accountability Policies

ERIC Educational Resources Information Center

Prezyna, Dolores Marie; Garrison, Mark J.; Lockte, Hilary A.; Gold, Carol P.

2017-01-01

This study investigates how the role of the reading specialist (RS) is defined and communicated by principals, and examines to what degree a common understanding of this role exists among teachers, building administrators and reading specialists. The principal's responsibility in defining and communicating role, and the effect these efforts have…
[Partnership around difficult teenagers in Brest].

PubMed

Saint-André, Stéphane; Botbol, Michel

2013-01-01

The issues surrounding difficult teenagers results in professionals formalising a partnership. Certain areas of focus are identified such as getting to know each other better in order to understand each other better, working in a "common language", understanding professional identities, or embracing long term partnership. Pressure to assess and rationalise spending, as well as political challenges, must be taken into consideration.
Compounding Confusion? When Illustrative Practical Work Falls Short of Its Purpose--A Case Study

ERIC Educational Resources Information Center

Haigh, Mavis; France, Beverley; Gounder, Roshni

2012-01-01

Illustrative practical work is commonly used in chemistry education to enrich students' understandings of chemical phenomena. However, it is possible that such practical work may not serve to foster understanding but rather cause further confusion. This paper reports the struggles experienced by a group of senior (Year 12) secondary chemistry…

Effect of Two-Tier Diagnostic Tests on Promoting Learners' Conceptual Understanding of Variables in Conducting Scientific Experiments

ERIC Educational Resources Information Center

Çil, Emine

2015-01-01

Taking a test generally improves the retention of the material tested. This is a phenomenon commonly referred to as testing effect. The present research investigated whether two-tier diagnostic tests promoted student teachers' conceptual understanding of variables in conducting scientific experiments, which is a scientific process skill. In this…
Marriage and Family Therapy Students' Experience with Common Factors Training.

PubMed

Fife, Stephen T; D'Aniello, Carissa; Scott, Sarah; Sullivan, Erin

2018-04-27

With the increased empirical and theoretical support for common factors in the psychotherapy literature, marriage and family therapy (MFT) scholars have begun discussing the inclusion of common factors in MFT training. However, there is very little empirical research on common factors training or how to include common factors in MFT curricula. The purpose of this phenomenological study was to investigate MFT students' experience with common factors training. Seventeen master's degree students who received training in common factors participated in the study. Data was comprised of participants' journal reflections and focus group interviews on their experience learning about common factors and how this influenced their work with clients. Participants' responses to the training were overwhelmingly positive and highlighted the ways in which studying common factors enhanced their confidence, understanding of MFT models, conceptual abilities, and clinical practice. Additional results and discussion about incorporating common factors in MFT training are presented. © 2018 American Association for Marriage and Family Therapy.
Guide to Understanding Lymphedema

MedlinePlus

... Therapy Expressive Writing Guided Imagery Hypnosis Massage Therapy Medical Marijuana Mindfulness-Based Stress Reduction Yoga and Breast Cancer Getting Started With Yoga Popular Yoga Styles Common ...
Common Core State Standards for Mathematics: Love It or Hate It, Understand Those Who Don't

ERIC Educational Resources Information Center

Wagner, Patty Anne

2016-01-01

In this commentary, Wagner points out that the Common Core State Standards for Mathematics (CCSSM) has fueled strong reactions on either end of the spectrum, compelling its supporters and critics to argue their positions. Naturally neither side have interest in entertaining the arguments of the other. Wagner claims, however, that you develop the…
Growing Awareness, Growing Support: Teacher and Voter Understanding of the Common Core State Standards & Assessments

ERIC Educational Resources Information Center

Achieve, Inc., 2012

2012-01-01

Since June 2010, 46 states and Washington DC have chosen to adopt the Common Core State Standards (CCSS)--K-12 standards in mathematics and English language arts/literacy developed through a multi-state initiative led by the National Governors Association and the Council of Chief State School Officers. As implementation of the standards is…
The Advantages of Repeat Interviews in a Study with Pregnant Schoolgirls and Schoolgirl Mothers: Piecing Together the Jigsaw

ERIC Educational Resources Information Center

Vincent, Kerry Anne

2013-01-01

Qualitative interviewing is a commonly used approach in the social sciences and is generally regarded as an effective way of developing understandings about everyday experiences and the meanings people attach to them. Where fieldwork time-frames are relatively short, a single interview with each participant is common. This paper explores the…
Opportunism in Buyer-Supplier Relations: New Insights From Quantitative Synthesis

DTIC Science & Technology

2006-03-20

the variance in the opportunism relationships. This 4 is highly functional. Academicians and practitioners would each benefit from understanding, with...1999) also support the theory. In a franchisor- franchisee relationship, opportunism is reduced by the use of written contracts and explicit procedures...commonly operationalized as solidarity (common responsibilities and interests), mutuality (mutual benefit and trust), flexibility (good faith
"Better to Be a Pessimist": A Narrative Inquiry into Mathematics Teachers' Experience of the Transition to the Common Core

ERIC Educational Resources Information Center

Martinie, Sherri L.; Kim, Jeong-Hee; Abernathy, Deborah

2016-01-01

The Common Core State Standards (CCSS) are a focus of state education policy today influencing curriculum implementation and assessment in public schools. The purpose of this narrative inquiry is to understand how high school mathematics teachers experience the transition period. Based on interviews with mathematics teachers in a high school in…
Common Metaphors and Their Impact on Distance Education: What They Tell Us and What They Hide

ERIC Educational Resources Information Center

Meyer, Katrina A.

2005-01-01

This article explores some of the common metaphors used to illuminate the Web and its application to distance education. Using the work of Lakoff and Johnson (1980) as a foundation for understanding and categorizing metaphors, the advantages and disadvantages for our future of such metaphors as the "Web", "Information Highway", "virtual",…
The CORE Community: Career and Technical Education Teachers' Perceptions of the Common Core State Standards

ERIC Educational Resources Information Center

Stair, Kristin S.; Warner, Wendy J; Hock, Gaea; Conrad, Michelle; Levy, Natalie

2016-01-01

The Common Core State Standards (CCSS) have been adopted in 43 states within the U.S. However, Career and Technical Education (CTE) teachers are often unsure how their programs can successfully integrate CCSS. The purpose of this study was to understand how participants in a CCSS professional development project perceive the CCSS and how they are…
The Pediatric Urinary Tract and Medical Imaging.

PubMed

Penny, Steven M

2016-01-01

The pediatric urinary tract often is assessed with medical imaging. Consequently, it is essential for medical imaging professionals to have a fundamental understanding of pediatric anatomy, physiology, and common pathology of the urinary tract to provide optimal patient care. This article provides an overview of fetal development, pediatric urinary anatomy and physiology, and common diseases and conditions of the pediatric urinary tract.
A Study of General Education Astronomy Students' Understandings of Cosmology. Part IV. Common Difficulties Students Experience with Cosmology

ERIC Educational Resources Information Center

Wallace, Colin S.; Prather, Edward E.; Duncan, Douglas K.

2012-01-01

This is our fourth paper in our five paper series describing our national study of general education astronomy students' conceptual and reasoning difficulties with cosmology. While previous papers in this series focused on the processes by which we collected and quantitatively analyzed our data, this paper presents the most common pre-instruction…
Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification.

PubMed

Maixner, William; Fillingim, Roger B; Williams, David A; Smith, Shad B; Slade, Gary D

2016-09-01

There is increasing recognition that many if not most common chronic pain conditions are heterogeneous with a high degree of overlap or coprevalence of other common pain conditions along with influences from biopsychosocial factors. At present, very little attention is given to the high degree of overlap of many common pain conditions when recruiting for clinical trials. As such, many if not most patients enrolled into clinical studies are not representative of most chronic pain patients. The failure to account for the heterogeneous and overlapping nature of most common pain conditions may result in treatment responses of small effect size when these treatments are administered to patients with chronic overlapping pain conditions (COPCs) represented in the general population. In this brief review we describe the concept of COPCs and the putative mechanisms underlying COPCs. Finally, we present a series of recommendations that will advance our understanding of COPCs. This brief review describes the concept of COPCs. A mechanism-based heuristic model is presented and current knowledge and evidence for COPCs are presented. Finally, a set of recommendations is provided to advance our understanding of COPCs. Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.
Mortality patterns in endangered Hawaiian geese (Nene; Branta sandvicensis)

USGS Publications Warehouse

Work, Thierry M.; Dagenais, Julie; Rameyer, Robert; Breeden, Renee

2015-01-01

Understanding causes of death can aid management and recovery of endangered bird populations. Toward those ends, we systematically examined 300 carcasses of endangered Hawaiian Geese (Nene; Branta sandvicensis) from Hawaii, Maui, Molokai, and Kauai between 1992 and 2013. The most common cause of death was emaciation, followed by trauma (vehicular strikes and predation), and infectious/inflammatory diseases of which toxoplasmosis (infection with Toxoplasma gondii) predominated. Toxicoses were less common and were dominated by lead poisoning or botulism. For captive birds, inflammatory conditions predominated, whereas emaciation, trauma, and inflammation were common in free-ranging birds. Mortality patterns were similar for males and females. Trauma predominated for adults, whereas emaciation was more common for goslings. Causes of death varied among islands, with trauma dominating on Molokai, emaciation and inflammation on Kauai, emaciation on Hawaii, and inflammation and trauma on Maui. Understanding habitat or genetic-related factors that predispose Nene (particularly goslings) to emaciation might reduce the impact of this finding. In addition, trauma and infection with T. gondii are human-related problems that may be attenuated if effectively managed (e.g., road signs, enforcement of speed limits, feral cat [Felis catus] control). Such management actions might serve to enhance recovery of this endangered species.
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models

PubMed Central

Samsom, James N.; Wong, Albert H. C.

2015-01-01

Patients with schizophrenia are at an increased risk for the development of depression. Overlap in the symptoms and genetic risk factors between the two disorders suggests a common etiological mechanism may underlie the presentation of comorbid depression in schizophrenia. Understanding these shared mechanisms will be important in informing the development of new treatments. Rodent models are powerful tools for understanding gene function as it relates to behavior. Examining rodent models relevant to both schizophrenia and depression reveals a number of common mechanisms. Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation. Neurotransmission, brain connectivity, the immune system, the environment, and metabolism emerge as potential common mechanisms linking these models and potentially explaining comorbid depression in schizophrenia. PMID:25762938
The application of systems thinking in health: why use systems thinking?

PubMed

Peters, David H

2014-08-26

This paper explores the question of what systems thinking adds to the field of global health. Observing that elements of systems thinking are already common in public health research, the article discusses which of the large body of theories, methods, and tools associated with systems thinking are more useful. The paper reviews the origins of systems thinking, describing a range of the theories, methods, and tools. A common thread is the idea that the behavior of systems is governed by common principles that can be discovered and expressed. They each address problems of complexity, which is a frequent challenge in global health. The different methods and tools are suited to different types of inquiry and involve both qualitative and quantitative techniques. The paper concludes by emphasizing that explicit models used in systems thinking provide new opportunities to understand and continuously test and revise our understanding of the nature of things, including how to intervene to improve people's health.
[Common sense, science and philosophy: the links of knowledge necessary for promoting health care].

PubMed

Rios, Ediara Rabello Girão; Franchi, Kristiane Mesquita Barros; da Silva, Raimunda Magalhães; de Amorim, Rosendo Freitas; Costa, Nhandeyjara de Carvalho

2007-01-01

In its evolution, humanity has accumulated data which were systematized as knowledge. Philosophy through self examination helps us in its practical and theoretical functions to reach a concept of the universe. Common sense helps science evolve. People's daily difficulties stir up the need for research, for deepening data interpretation and to propose solutions to overcome the population's problems. Science exists to explain difficult aspects of common sense, to support questions, as well as to substantiate knowledge produced as a response to demands. Thus, knowledge involved in this reflection sets out to foster an articulation between basic forms of knowledge and to develop a satisfactory understanding of the health care process, through a shared and critically consciousness view of the changes in the health system's paradigm. We understand that health education is an essential component within this process, provided that it is focused primarily on an individual belonging to a community with its multiple relationships, especially between the community context and the subjective dimension, which can provide citizenship empowerment redemption.
Evaluation of Students' Conceptual Understanding of Malaria

NASA Astrophysics Data System (ADS)

Poh-Ai Cheong, Irene; Treagust, David; Kyeleve, Iorhemen J.; Oh, Peck-Yoke

2010-12-01

In this study, a two-tier diagnostic test for understanding malaria was developed and administered to 314 Bruneian students in Year 12 and in a nursing diploma course. The validity, reliability, difficulty level, discriminant indices, and reading ability of the test were examined and found to be acceptable in terms of measuring students' understanding and identifying alternative conceptions with respect to malaria. Results showed that students' understanding of malaria was high for content, low for reasons, and limited and superficial for both content and reasons. The instrument revealed several common alternative conceptual understandings students' hold about malaria. The MalariaTT2 instrument developed could be used in classroom lessons for challenging alternative conceptions and enhancing conceptions of malaria.
Lightness Constancy in Surface Visualization

PubMed Central

Szafir, Danielle Albers; Sarikaya, Alper; Gleicher, Michael

2016-01-01

Color is a common channel for displaying data in surface visualization, but is affected by the shadows and shading used to convey surface depth and shape. Understanding encoded data in the context of surface structure is critical for effective analysis in a variety of domains, such as in molecular biology. In the physical world, lightness constancy allows people to accurately perceive shadowed colors; however, its effectiveness in complex synthetic environments such as surface visualizations is not well understood. We report a series of crowdsourced and laboratory studies that confirm the existence of lightness constancy effects for molecular surface visualizations using ambient occlusion. We provide empirical evidence of how common visualization design decisions can impact viewers’ abilities to accurately identify encoded surface colors. These findings suggest that lightness constancy aids in understanding color encodings in surface visualization and reveal a correlation between visualization techniques that improve color interpretation in shadow and those that enhance perceptions of surface depth. These results collectively suggest that understanding constancy in practice can inform effective visualization design. PMID:26584495
Understanding and preventing contrast-induced acute kidney injury.

PubMed

Fähling, Michael; Seeliger, Erdmann; Patzak, Andreas; Persson, Pontus B

2017-03-01

Contrast-induced acute kidney injury (CIAKI) occurs in up to 30% of patients who receive iodinated contrast media and is generally considered to be the third most common cause of hospital-acquired AKI. Accurate assessment of the incidence of CIAKI is obscured, however, by the use of various definitions for diagnosis, the different populations studied and the prophylactic measures put in place. A deeper understanding of the mechanisms that underlie CIAKI is required to enable reliable risk assessment for individual patients, as their medical histories will determine the specific pathways by which contrast media administration might lead to kidney damage. Here, we highlight common triggers that prompt the development of CIAKI and the subsequent mechanisms that ultimately cause kidney damage. We also discuss effective protective measures, such as rapidly acting oral hydration schemes and loop diuretics, in the context of CIAKI pathophysiology. Understanding of how CIAKI arises in different patient groups could enable a marked reduction in incidence and improved outcomes. The ultimate goal is to shape CIAKI prevention strategies for individual patients.

Cardiac Hemodynamics in the Pathogenesis of Congenital Heart Disease and Aortic Valve Calcification

NASA Astrophysics Data System (ADS)

Nigam, Vishal

2011-11-01

An improved understanding of the roles of hemodynamic forces play in cardiac development and the pathogenesis of cardiac disease will have significant scientific and clinical impact. I will focus on the role of fluid dynamics in congenital heart disease and aortic valve calcification. Congenital heart defects are the most common form of birth defect. Aortic valve calcification/stenosis is the third leading cause of adult heart disease and the most common form of acquired valvular disease in developed countries. Given the high incidence of these diseases and their associated morbidity and mortality, the potential translational impact of an improved understanding of cardiac hemodynamic forces is very large. Division of Pediatric Cardiology, Rady Children's Hospital, San Diego
Health economic evaluation: important principles and methodology.

PubMed

Rudmik, Luke; Drummond, Michael

2013-06-01

To discuss health economic evaluation and improve the understanding of common methodology. This article discusses the methodology for the following types of economic evaluations: cost-minimization, cost-effectiveness, cost-utility, cost-benefit, and economic modeling. Topics include health-state utility measures, the quality-adjusted life year (QALY), uncertainty analysis, discounting, decision tree analysis, and Markov modeling. Economic evaluation is the comparative analysis of alternative courses of action in terms of both their costs and consequences. With increasing health care expenditure and limited resources, it is important for physicians to consider the economic impact of their interventions. Understanding common methodology involved in health economic evaluation will improve critical appraisal of the literature and optimize future economic evaluations. Copyright © 2012 The American Laryngological, Rhinological and Otological Society, Inc.
Orbital Noise in the Earth System is a Common Cause of Climate and Greenhouse-Gas Fluctuation

NASA Technical Reports Server (NTRS)

Liu, H. S.; Kolenkiewicz, R.; Wade, C., Jr.; Smith, David E. (Technical Monitor)

2002-01-01

The mismatch between fossil isotopic data and climate models known as the cool-tropic paradox implies that either the data are flawed or we understand very little about the climate models of greenhouse warming. Here we question the validity of the climate models on the scientific background of orbital noise in the Earth system. Our study shows that the insolation pulsation induced by orbital noise is the common cause of climate change and atmospheric concentrations of carbon dioxide and methane. In addition, we find that the intensity of the insolation pulses is dependent on the latitude of the Earth. Thus, orbital noise is the key to understanding the troubling paradox in climate models.
Spirituality and Religion among the General Public: Implications for Social Work Discourse.

PubMed

Hodge, David R

2015-07-01

Conceptualizations play a central role in social work discourse, shaping actions in the areas of practice, research, and education. Although many formulations of spirituality and religion have been advanced by social work scholars, the views of members of the general public have been largely absent from the professional conversation. The present article adds to the profession's evolving discussion on spirituality and religion by describing common understandings of spirituality and religion among the general population and by discussing the implication of these views for social work discourse on spirituality and religion. By understanding common views among the public, the social work profession is better positioned to provide ethical and professional services that respect clients' spiritual beliefs and values.
Proceedings of the 11th United States-Japan natural resources panel for earthquake research, Napa Valley, California, November 16–18, 2016

USGS Publications Warehouse

Detweiler, Shane; Pollitz, Fred

2017-10-18

The UJNR Panel on Earthquake Research promotes advanced research toward a more fundamental understanding of the earthquake process and hazard estimation. The Eleventh Joint meeting was extremely beneficial in furthering cooperation and deepening understanding of problems common to both Japan and the United States.The meeting included productive exchanges of information on approaches to systematic observation and modeling of earthquake processes. Regarding the earthquake and tsunami of March 2011 off the Pacific coast of Tohoku and the 2016 Kumamoto earthquake sequence, the Panel recognizes that further efforts are necessary to achieve our common goal of reducing earthquake risk through close collaboration and focused discussions at the 12th UJNR meeting.
Learning and Literacy in an Online Gaming Community: Examples of Participatory Practices in a Sims Affinity Space

ERIC Educational Resources Information Center

Lee, Yoonhee Naseef

2012-01-01

The goal of this research was to understand the different kinds of learning that take place in "Mod The Sims" (MTS), an online "Sims" gaming community. The study aimed to explore users' experiences and to understand learning practices that are not commonly observed in formal educational settings. To achieve this goal, the…
A Tangled Web of Terms: The Overlap and Unique Contribution of Involvement, Engagement, and Integration to Understanding College Student Success

ERIC Educational Resources Information Center

Wolf-Wendel, Lisa; Ward, Kelly; Kinzie, Jillian

2009-01-01

Established theories and constructs long associated with student success, including involvement, engagement, and integration, provide common language and a body of knowledge to inform understanding of the challenges currently facing higher education. This paper examines how the theories and terms have evolved, explores how the terms are currently…
Correlation, Necessity, and Sufficiency: Common Errors in the Scientific Reasoning of Undergraduate Students for Interpreting Experiments

ERIC Educational Resources Information Center

Coleman, Aaron B.; Lam, Diane P.; Soowal, Lara N.

2015-01-01

Gaining an understanding of how science works is central to an undergraduate education in biology and biochemistry. The reasoning required to design or interpret experiments that ask specific questions does not come naturally, and is an essential part of the science process skills that must be learned for an understanding of how scientists conduct…
Learner-Centred Teaching Contributes in Promising Results in Improving Learner Understanding and Motivation: A Case Study at Malaysia Tertiary Education

ERIC Educational Resources Information Center

Yap, Wei-Li; Neo, Mai; Neo, Tse-Kian

2016-01-01

In Malaysia, traditional teaching is still a common approach among many lecturers. There have been many studies that have reported its limitations and many lecturers have started to adopt a more learner-centred teaching approach to promote better learner understanding and learner motivation. Throughout this effort, it is noticed there are…
A Case Study Exploring the Perceptions of Educational Technology Leadership in a Rural School District

ERIC Educational Resources Information Center

Lichucki, Michael

2013-01-01

Although technology is common in our society, it has not universally become an expected practice in our schools. The problem that was addressed by the qualitative, case study design is that teachers and administrators do not share an understanding of educational technology leadership. School leaders that do not understand the needs of classroom…
Going beyond the Mean: Using Variances to Enhance Understanding of the Impact of Educational Interventions for Multilevel Models

ERIC Educational Resources Information Center

Peralta, Yadira; Moreno, Mario; Harwell, Michael; Guzey, S. Selcen; Moore, Tamara J.

2018-01-01

Variance heterogeneity is a common feature of educational data when treatment differences expressed through means are present, and often reflects a treatment by subject interaction with respect to an outcome variable. Identifying variables that account for this interaction can enhance understanding of whom a treatment does and does not benefit in…
Root-Metaphors for Understanding: A Framework for Teachers and Teacher Educators of Information and Communication Technologies

ERIC Educational Resources Information Center

Kilbourn, Brent; Alvarez, Isabel

2008-01-01

This paper argues for understanding ICT from the standpoint of philosophical world views. We present a framework, based on Pepper's root-metaphors (Formism, Contextualism, Mechanism, Organicism, and Animism/Mysticism) and we illustrate the use of the framework by looking at a common example of ICT: e-mail. It is argued that such a framework is…
Understanding social complexity within the wildland urban interface: A new species of human habitation? Environmental Management

Treesearch

Travis B. Paveglio; Pamela J. Jakes; Matthew S. Carroll; Daniel R. Williams

2009-01-01

The lack of knowledge regarding social diversity in the Wildland Urban Interface (WUI) or an in-depth understanding of the ways people living there interact to address common problems is concerning, perhaps even dangerous, given that community action is necessary for successful wildland fire preparedness and natural resource management activities. In this article, we...
The Use of Applets for Developing Understanding in Mathematics: A Case Study Using Maplets for Calculus with Continuity Concepts

ERIC Educational Resources Information Center

Patenaude, Raymond E.

2013-01-01

The Common Core State Standards for Mathematics (CCSSM) are founded on a long history of mathematics education research emphasizing the importance of teaching mathematics for understanding. The CCSSM along with the National Council of Teachers of Mathematics (NCTM) recommend the use of technology in the teaching of mathematics. New mobile…
Seventh Grade Students' Conceptual Understanding about Citizenship: Does a Constructivist Social Studies Program Make a Difference?

ERIC Educational Resources Information Center

Sabanci, Osman; Kurnaz, Sefika; Yürük, Nejla

2016-01-01

Many studies have shown that students at different age levels come into classrooms with a variety of alternative conceptions. Commonly held alternative conceptions are the main source of the difficulties that students and teachers face in learning and teaching. The aim of this study was to compare the conceptual understanding of students who were…
A Framework for Mathematics Graphical Tasks: The Influence of the Graphic Element on Student Sense Making

ERIC Educational Resources Information Center

Lowrie, Tom; Diezmann, Carmel M.; Logan, Tracy

2012-01-01

Graphical tasks have become a prominent aspect of mathematics assessment. From a conceptual stance, the purpose of this study was to better understand the composition of graphical tasks commonly used to assess students' mathematics understandings. Through an iterative design, the investigation described the sense making of 11-12-year-olds as they…
Pre-College Deaf Students' Understanding of Fractional Concepts: What We Know and What We Do Not Know

ERIC Educational Resources Information Center

Mousley, Keith; Kurz, Christopher

2015-01-01

Mathematical knowledge and skills are crucial to success in academics and the workplace. The Common Core State Standards emphasizes fraction teaching and learning in elementary school. This mixed-method study explores fraction concept understanding among 14 deaf and hard of hearing participants between the ages of 8 and 16, as quantitatively…
Understanding Subgroups in Common State Assessments: Special Education Students and ELLs. NCEO Brief. Number 4

ERIC Educational Resources Information Center

National Center on Educational Outcomes, University of Minnesota, 2011

2011-01-01

Although most assessment developers have a sense of the nature of the general student population, they often lack an understanding of the characteristics of special education students and English Language Learners (ELLs) who will participate in the assessment. The Race-to-the-Top Assessment Consortia have the rare opportunity to know who these…
Earthquake Potential of the St. Louis District

DTIC Science & Technology

1981-02-01

The trends of the fault plane solutions strike northwest, northeast, and north-south indicating a complex generating mechanism . The focal depth for...thrust, strike-slip, oblique) is of prime importance in understanding seismic activity. Focal Mechanism Studies: A common method of obtaining regional... focal mechanisms , and to better understand magnitude-recurrence relations. Gravity and Magnetics: Gravity and magnetic contours may be used to
Simulating the Composite Propellant Manufacturing Process

NASA Technical Reports Server (NTRS)

Williamson, Suzanne; Love, Gregory

2000-01-01

There is a strategic interest in understanding how the propellant manufacturing process contributes to military capabilities outside the United States. The paper will discuss how system dynamics (SD) has been applied to rapidly assess the capabilities and vulnerabilities of a specific composite propellant production complex. These facilities produce a commonly used solid propellant with military applications. The authors will explain how an SD model can be configured to match a specific production facility followed by a series of scenarios designed to analyze operational vulnerabilities. By using the simulation model to rapidly analyze operational risks, the analyst gains a better understanding of production complexities. There are several benefits of developing SD models to simulate chemical production. SD is an effective tool for characterizing complex problems, especially the production process where the cascading effect of outages quickly taxes common understanding. By programming expert knowledge into an SD application, these tools are transformed into a knowledge management resource that facilitates rapid learning without requiring years of experience in production operations. It also permits the analyst to rapidly respond to crisis situations and other time-sensitive missions. Most importantly, the quantitative understanding gained from applying the SD model lends itself to strategic analysis and planning.

Acute poisoning: understanding 90% of cases in a nutshell

PubMed Central

Greene, S; Dargan, P; Jones, A

2005-01-01

The acutely poisoned patient remains a common problem facing doctors working in acute medicine in the United Kingdom and worldwide. This review examines the initial management of the acutely poisoned patient. Aspects of general management are reviewed including immediate interventions, investigations, gastrointestinal decontamination techniques, use of antidotes, methods to increase poison elimination, and psychological assessment. More common and serious poisonings caused by paracetamol, salicylates, opioids, tricyclic antidepressants, selective serotonin reuptake inhibitors, benzodiazepines, non-steroidal anti-inflammatory drugs, and cocaine are discussed in detail. Specific aspects of common paediatric poisonings are reviewed. PMID:15811881
Acute poisoning: understanding 90% of cases in a nutshell.

PubMed

Greene, S L; Dargan, P I; Jones, A L

2005-04-01

The acutely poisoned patient remains a common problem facing doctors working in acute medicine in the United Kingdom and worldwide. This review examines the initial management of the acutely poisoned patient. Aspects of general management are reviewed including immediate interventions, investigations, gastrointestinal decontamination techniques, use of antidotes, methods to increase poison elimination, and psychological assessment. More common and serious poisonings caused by paracetamol, salicylates, opioids, tricyclic antidepressants, selective serotonin reuptake inhibitors, benzodiazepines, non-steroidal anti-inflammatory drugs, and cocaine are discussed in detail. Specific aspects of common paediatric poisonings are reviewed.
Sex-based Differences in Common Sports Injuries.

PubMed

Carter, Cordelia W; Ireland, Mary Lloyd; Johnson, Anthony E; Levine, William N; Martin, Scott; Bedi, Asheesh; Matzkin, Elizabeth G

2018-05-28

The patient's sex plays an important role in mediating the risk for, and experience of, disease. Injuries of the musculoskeletal system are no exception to this phenomenon. Increasing evidence shows that the incidence, clinical presentation, and treatment outcomes for male and female patients with common sports injuries may vary widely. Stress fracture, which is associated with the female athlete triad, is a sports injury with known sex-based differences. Other common sports-related injuries may also have distinct sex-based differences. Understanding these differences is important to optimize each patient's musculoskeletal care.
Guide to Understanding Triple-Negative Breast Cancer

MedlinePlus

... Therapy Expressive Writing Guided Imagery Hypnosis Massage Therapy Medical Marijuana Mindfulness-Based Stress Reduction Yoga and Breast Cancer Getting Started With Yoga Popular Yoga Styles Common ...
De novo assembly and characterization of the spleen transcriptome of common carp (Cyprinus carpio) using Illumina paired-end sequencing.

PubMed

Li, Guoxi; Zhao, Yinli; Liu, Zhonghu; Gao, Chunsheng; Yan, Fengbin; Liu, Bianzhi; Feng, Jianxin

2015-06-01

Common carp (Cyprinus carpio) is one of the most important aquacultured species of the family Cyprinidae, and breeding this species for disease resistance is becoming more and more important. However, at the genome or transcriptome levels, study of the immunogenetics of disease resistance in the common carp is lacking. In this study, 60,316,906 and 75,200,328 paired-end clean reads were obtained from two cDNA libraries of the common carp spleen by Illumina paired-end sequencing technology. Totally, 130,293 unique transcript fragments (unigenes) were assembled, with an average length of 1400.57 bp. Approximately 105,612 (81.06%) unigenes could be annotated according to their homology with matches in the Nr, Nt, Swiss-Prot, COG, GO, or KEGG databases, and they were found to represent 46,747 non-redundant genes. Comparative analysis showed that 59.82% of the unigenes have significant similarity to zebrafish Refseq proteins. Gene expression comparison revealed that 10,432 and 6889 annotated unigenes were, respectively, up- and down-regulated with at least twofold changes between two developmental stages of the common carp spleen. Gene ontology and KEGG analysis were performed to classify all unigenes into functional categories for understanding gene functions and regulation pathways. In addition, 46,847 simple sequence repeats (SSRs) were detected from 35,618 unigenes, and a large number of single nucleotide polymorphism (SNP) and insertion/deletion (INDEL) sites were identified in the spleen transcriptome of common carp. This study has characterized the spleen transcriptome of the common carp for the first time, providing a valuable resource for a better understanding of the common carp immune system and defense mechanisms. This knowledge will also facilitate future functional studies on common carp immunogenetics that may eventually be applied in breeding programs. Copyright © 2015 Elsevier Ltd. All rights reserved.
The Language of Scholarship: How to Rapidly Locate and Avoid Common APA Errors.

PubMed

Freysteinson, Wyona M; Krepper, Rebecca; Mellott, Susan

2015-10-01

This article is relevant for nurses and nursing students who are writing scholarly documents for work, school, or publication and who have a basic understanding of American Psychological Association (APA) style. Common APA errors on the reference list and in citations within the text are reviewed. Methods to quickly find and reduce those errors are shared. Copyright 2015, SLACK Incorporated.
Review for the generalist: evaluation of pediatric foot and ankle pain

PubMed Central

Houghton, Kristin M

2008-01-01

Foot and ankle pain is common in children and adolescents. Problems are usually related to skeletal maturity and are fairly specific to the age of the child. Evaluation and management is challenging and requires a thorough history and physical exam, and understanding of the pediatric skeleton. This article will review common causes of foot and ankle pain in the pediatric population. PMID:18400098
Consequences of data reduction in the FIA database: a case study with southern yellow pine

Treesearch

Anita K. Rose; James F. Rosson Jr.; Helen Beresford

2015-01-01

The Forest Inventory and Analysis Program strives to make its data publicly available in a format that is easy to use and understand most commonly accessed through online tools such as EVALIDator and Forest Inventory Data Online. This requires a certain amount of data reduction. Using a common data request concerning the resource of southern yellow pine (SYP), we...
Universal Declaration of Human Rights, A Lay Version for the Common Man, Woman and Child.

ERIC Educational Resources Information Center

Tankard, Alice Doumanian

This lay version of the Universal Declaration of Human Rights (the original version was adopted by the General Assembly of the United Nations in 1948) has been written in simplified vocabulary to make it understandable to a wider range of ages and reading abilities. The declaration consists of a preamble followed by a listing of 30 goals common to…
Common pitfalls in statistical analysis: Absolute risk reduction, relative risk reduction, and number needed to treat

PubMed Central

Ranganathan, Priya; Pramesh, C. S.; Aggarwal, Rakesh

2016-01-01

In the previous article in this series on common pitfalls in statistical analysis, we looked at the difference between risk and odds. Risk, which refers to the probability of occurrence of an event or outcome, can be defined in absolute or relative terms. Understanding what these measures represent is essential for the accurate interpretation of study results. PMID:26952180
Conceptualizing Rigor and Its Implications for Education in the Era of the Common Core

ERIC Educational Resources Information Center

Paige, David D.; Smith, Grant S.; Sizemore, John M.

2015-01-01

The adoption of Common Core State Standards in the USA by 46 states and the District of Columbia has provided several new foci for K-12 instruction, not the least of which is the reading and understanding of complex text, a higher order thinking process. Closely associated with this is the notion of rigor, the focus of the present study. As…
A food web modeling analysis of a Midwestern, USA eutrophic lake dominated by non-native Common Carp and Zebra Mussels

USGS Publications Warehouse

Colvin, Michael E.; Pierce, Clay; Stewart, Timothy W.

2015-01-01

Food web modeling is recognized as fundamental to understanding the complexities of aquatic systems. Ecopath is the most common mass-balance model used to represent food webs and quantify trophic interactions among groups. We constructed annual Ecopath models for four consecutive years during the first half-decade of a zebra mussel invasion in shallow, eutrophic Clear Lake, Iowa, USA, to evaluate changes in relative biomass and total system consumption among food web groups, evaluate food web impacts of non-native common carp and zebra mussels on food web groups, and to interpret food web impacts in light of on-going lake restoration. Total living biomass increased each year of the study; the majority of the increase due to a doubling in planktonic blue green algae, but several other taxa also increased including a more than two-order of magnitude increase in zebra mussels. Common carp accounted for the largest percentage of total fish biomass throughout the study even with on-going harvest. Chironomids, common carp, and zebra mussels were the top-three ranking consumer groups. Non-native common carp and zebra mussels accounted for an average of 42% of the total system consumption. Despite the relatively high biomass densities of common carp and zebra mussel, food web impacts was minimal due to excessive benthic and primary production in this eutrophic system. Consumption occurring via benthic pathways dominated system consumption in Clear Lake throughout our study, supporting the argument that benthic food webs are significant in shallow, eutrophic lake ecosystems and must be considered if ecosystem-level understanding is to be obtained.
Narratives Reflecting the Lived Experiences of People with Brain Disorders: Common Psychosocial Difficulties and Determinants

PubMed Central

Hartley, Sally; McArthur, Maggie; Coenen, Michaela; Cabello, Maria; Covelli, Venusia; Roszczynska-Michta, Joanna; Pitkänen, Tuuli; Bickenbach, Jerome; Cieza, Alarcos

2014-01-01

Background People with brain disorders - defined as both, mental disorders and neurological disorders experience a wide range of psychosocial difficulties (PSDs) (e.g., concentrating, maintaining energy levels, and maintaining relationships). Research evidence is required to show that these PSDs are common across brain disorders. Objectives To explore and gain deeper understanding of the experiences of people with seven brain disorders (alcohol dependency, depression, epilepsy, multiple sclerosis, Parkinson’s disease, schizophrenia, stroke). It examines the common PSDs and their influencing factors. Methods Seventy seven qualitative studies identified in a systematic literature review and qualitative data derived from six focus groups are used to generate first-person narratives representing seven brain disorders. A theory-driven thematic analysis of these narratives identifies the PSDs and their influencing factors for comparison between the seven disorders. Results First-person narratives illustrate realities for people with brain disorders facilitating a deeper understanding of their every-day life experiences. Thematic analysis serves to highlight the commonalities, both of PSDs, such as loneliness, anger, uncertainty about the future and problems with work activities, and their determinants, such as work opportunities, trusting relationships and access to self-help groups. Conclusions The strength of the methodology and the narratives is that they provide the opportunity for the reader to empathise with people with brain disorders and facilitate deeper levels of understanding of the complexity of the relationship of PSDs, determinants and facilitators. The latter reflect positive aspects of the lives of people with brain disorders. The result that many PSDs and their influencing factors are common to people with different brain disorders opens up the door to the possibility of using cross-cutting interventions involving different sectors. This strengthens the message that ‘a great deal can be done’ to improve the lived experience of persons with brain disorders when medical interventions are exhausted. PMID:24805128
Integrated Data & Analysis in Support of Informed and Transparent Decision Making

NASA Astrophysics Data System (ADS)

Guivetchi, K.

2012-12-01

The California Water Plan includes a framework for improving water reliability, environmental stewardship, and economic stability through two initiatives - integrated regional water management to make better use of local water sources by integrating multiple aspects of managing water and related resources; and maintaining and improving statewide water management systems. The Water Plan promotes ways to develop a common approach for data standards and for understanding, evaluating, and improving regional and statewide water management systems, and for common ways to evaluate and select from alternative management strategies and projects. The California Water Plan acknowledges that planning for the future is uncertain and that change will continue to occur. It is not possible to know for certain how population growth, land use decisions, water demand patterns, environmental conditions, the climate, and many other factors that affect water use and supply may change by 2050. To anticipate change, our approach to water management and planning for the future needs to consider and quantify uncertainty, risk, and sustainability. There is a critical need for information sharing and information management to support over-arching and long-term water policy decisions that cross-cut multiple programs across many organizations and provide a common and transparent understanding of water problems and solutions. Achieving integrated water management with multiple benefits requires a transparent description of dynamic linkages between water supply, flood management, water quality, land use, environmental water, and many other factors. Water Plan Update 2013 will include an analytical roadmap for improving data, analytical tools, and decision-support to advance integrated water management at statewide and regional scales. It will include recommendations for linking collaborative processes with technical enhancements, providing effective analytical tools, and improving and sharing data and information. Specifically, this includes achieving better integration and consistency with other planning activities; obtaining consensus on quantitative deliverables; building a common conceptual understanding of the water management system; developing common schematics of the water management system; establishing modeling protocols and standards; and improving transparency and exchange of Water Plan information.
Teamwork: a concept analysis.

PubMed

Xyrichis, Andreas; Ream, Emma

2008-01-01

This paper is a report of an analysis of the concept of teamwork. Teamwork is seen as an important facilitator in delivering quality healthcare services internationally. However, research studies of teamwork in health care are criticized for lacking a basic conceptual understanding of what this concept represents. A universal definition for healthcare settings and professionals is missing from published literature. Walker and Avant's approach was used to guide this concept analysis. Literature searches used bibliographic databases (Medline, CINAHL, Web of Science, Proquest CSA), internet search engines (GoogleScholar), and hand searches. Literature published between 1976 and 2006 was reviewed but only material in English was included. Based on the analysis undertaken, teamwork is proposed as a dynamic process involving two or more healthcare professionals with complementary backgrounds and skills, sharing common health goals and exercising concerted physical and mental effort in assessing, planning, or evaluating patient care. This is accomplished through interdependent collaboration, open communication and shared decision-making, and generates value-added patient, organizational and staff outcomes. Praising the value of teamwork without a common understanding of what this concept represents endangers both research into this way of working and its effective utilization in practice. The proposed definition helps reconcile discrepancies between how this concept is understood by nurses and doctors, as well as allied health professionals. A common understanding can facilitate communication in educational, research and clinical settings and is imperative for improving clarity and validity of future research.
Health information technology adoption: Understanding research protocols and outcome measurements for IT interventions in health care.

PubMed

Colicchio, Tiago K; Facelli, Julio C; Del Fiol, Guilherme; Scammon, Debra L; Bowes, Watson A; Narus, Scott P

2016-10-01

To classify and characterize the variables commonly used to measure the impact of Information Technology (IT) adoption in health care, as well as settings and IT interventions tested, and to guide future research. We conducted a descriptive study screening a sample of 236 studies from a previous systematic review to identify outcome measures used and the availability of data to calculate these measures. We also developed a taxonomy of commonly used measures and explored setting characteristics and IT interventions. Clinical decision support is the most common intervention tested, primarily in non-hospital-based clinics and large academic hospitals. We identified 15 taxa representing the 79 most commonly used measures. Quality of care was the most common category of these measurements with 62 instances, followed by productivity (11 instances) and patient safety (6 instances). Measures used varied according to type of setting, IT intervention and targeted population. This study provides an inventory and a taxonomy of commonly used measures that will help researchers select measures in future studies as well as identify gaps in their measurement approaches. The classification of the other protocol components such as settings and interventions will also help researchers identify underexplored areas of research on the impact of IT interventions in health care. A more robust and standardized measurement system and more detailed descriptions of interventions and settings are necessary to enable comparison between studies and a better understanding of the impact of IT adoption in health care settings. Copyright © 2016 Elsevier Inc. All rights reserved.
Importance of Applying Condiments in a Commonly Consumed Food System for Understanding the Association Between Familiarity and Sensory Drivers of Liking: A Study Focused on Doenjang.

PubMed

Roh, Soo Hyun; Lee, Soh Min; Kim, Sang Sook; Kim, Kwang-Ok

2018-02-01

Doenjang, a Korean traditional fermented soybean paste, is one of the most essential condiments in Korean cuisine. Condiments are rarely consumed as it is, and are generally applied to other foods. The objective of this study was to understand how sensory drivers of liking of Doenjang would be affected according to food forms in which it is evaluated: the original paste form compared with a normally consumed soup form, and to understand the association of familiarity of evaluated food form. Descriptive analysis and consumer acceptability test was performed in 2 consumption forms: the original paste form and the Doenjang soup from. For consumer liking test, elderly consumers who have more experience to traditional Deonjang were compared to the young in their response to Doenjang paste and soup. The descriptive analysis results showed that the characteristic sensory features of the Deonjang samples were little affected based on the food system in which it was evaluated. However, when the paste was applied in soup, the intensities of the characteristic sensory features were reduced. Acceptability and familiarity of traditional type Doenjang samples for the young and for the elderly consumers were very similar in paste, but it differed when the samples were evaluated in soup. Thus, expectation difference between the young and the elderly was better revealed in soup, a more common food form consumed in practice. The results of this study indicate the importance of understanding sensory drivers of liking for a condiment such as Doenjang in their commonly consumed forms. Compared to the original condiment form, expectation difference between the young and the elderly were better revealed in Deonjang soup, a food form normally consumed in practice. Thus, the results of this study reinforced the importance of investigating sensory drivers of liking for a condiment in a food form that is normally consumed in practice for accurate understanding on consumer preference. © 2018 Institute of Food Technologists®.
Intravascular ultrasound

MedlinePlus

... heart attack. IVUS has helped providers understand how stents become clogged. This is called stent restenosis. ... IVUS is commonly done to make sure a stent is correctly placed during angioplasty. It may also ...
Recognising and understanding Lyme disease.

PubMed

Pearson, Sandra

2014-09-09

Lyme disease is the most common vector-borne disease in the northern hemisphere and its incidence is rising, leading to increased public health concerns. It is important to understand the nature of the disease because this defines the limitations of current understanding and knowledge. Significant uncertainties in diagnostics and treatment remain. There is an important role for the nurse in raising awareness, giving advice on prevention and correct tick removal, and in recognising signs of Lyme disease to assist access to prompt medical attention. Increased awareness, further research, improved diagnostics and advances in therapeutics are urgently required.
Understanding quantitative research: part 1.

PubMed

Hoe, Juanita; Hoare, Zoë

This article, which is the first in a two-part series, provides an introduction to understanding quantitative research, basic statistics and terminology used in research articles. Critical appraisal of research articles is essential to ensure that nurses remain up to date with evidence-based practice to provide consistent and high-quality nursing care. This article focuses on developing critical appraisal skills and understanding the use and implications of different quantitative approaches to research. Part two of this article will focus on explaining common statistical terms and the presentation of statistical data in quantitative research.

EMB history to increase health technology literacy in the general public for improved health worldwide.

PubMed

Leder, Ron S

2009-01-01

History provides common access to technology for both technical and non technical persons and for youngsters. Placed in an historical context complex health technology and health care can be more understandable and therefore more accessible to the general public; technical persons can understand past health technology advances to help propel the field. History is a reference for experts disguised as a story that anyone can understand and enjoy. This can be useful and effective at improving self advocate based health care.
Approaching Authentic Assessment: Using Virtual School Teachers' Expertise to Develop an Understanding of Full Time K-8 Virtual School Teacher Practices

ERIC Educational Resources Information Center

Seamster, Christina Lambert

2016-01-01

According to Molnar (2014), full time virtual school education lacks a measurement tool that accurately measures effective virtual teacher practice. Using both qualitative and quantitative methods, the current study sought to understand the common practices among full time K-8 virtual school teachers, the extent to which teachers believed such…
Marr: Magpie or Marsh Harrier? The Quest for the Common Characteristics of the Genus "Historian" with 16- to 19-Year-Olds

ERIC Educational Resources Information Center

Laffin, Diana

2012-01-01

Diana Laffin writes about historical language and explores how understanding different historians' use of language can help sixth form students refine and deepen both their understanding of the discipline of history and their abilities to practise the discipline in their own writing. What does close study of the textual habits and practices of…
Climate modeling. [for use in understanding earth's radiation budget

NASA Technical Reports Server (NTRS)

1978-01-01

The requirements for radiation measurements suitable for the understanding, improvement, and verification of models used in performing climate research are considered. Both zonal energy balance models and three dimensional general circulation models are considered, and certain problems are identified as common to all models. Areas of emphasis include regional energy balance observations, spectral band observations, cloud-radiation interaction, and the radiative properties of the earth's surface.
Using Surveillance of Mental Health to Increase Understanding of Youth Involvement in High-Risk Behaviors: A Value-Added Analysis

ERIC Educational Resources Information Center

Dowdy, Erin; Furlong, Michael J.; Sharkey, Jill D.

2013-01-01

This study examined the potential utility of adding items that assessed youths' emotional and behavioral disorders to a commonly used surveillance survey. The goal was to evaluate whether the added items could enhance understanding of youths' involvement in high-risk behaviors. A sample of 3,331 adolescents in Grades 8, 10, and 12 from four…
An Examination of Teacher Understanding of Project Based Science as a Result of Participating in an Extended Professional Development Program: Implications for Implementation

ERIC Educational Resources Information Center

Mentzer, Gale A.; Czerniak, Charlene M.; Brooks, Lisa

2017-01-01

Project-based science (PBS) aligns with national standards that assert children should learn science by actively engaging in the practices of science. Understanding and implementing PBS requires a shift in teaching practices away from one that covers primarily content to one that prompts children to conduct investigations. A common challenge to…
Making Sense of Low Back Pain and Pain-Related Fear.

PubMed

Bunzli, Samantha; Smith, Anne; Schütze, Robert; Lin, Ivan; O'Sullivan, Peter

2017-09-01

Synopsis Pain-related fear is implicated in the transition from acute to chronic low back pain and the persistence of disabling low back pain, making it a key target for physical therapy intervention. The current understanding of pain-related fear is that it is a psychopathological problem, whereby people who catastrophize about the meaning of pain become trapped in a vicious cycle of avoidance behavior, pain, and disability, as recognized in the fear-avoidance model. However, there is evidence that pain-related fear can also be seen as a common-sense response to deal with low back pain, for example, when one is told that one's back is vulnerable, degenerating, or damaged. In this instance, avoidance is a common-sense response to protect a "damaged" back. While the fear-avoidance model proposes that when someone first develops low back pain, the confrontation of normal activity in the absence of catastrophizing leads to recovery, the pathway to recovery for individuals trapped in the fear-avoidance cycle is less clear. Understanding pain-related fear from a common-sense perspective enables physical therapists to offer individuals with low back pain and high fear a pathway to recovery by altering how they make sense of their pain. Drawing on a body of published work exploring the lived experience of pain-related fear in people with low back pain, this clinical commentary illustrates how Leventhal's common-sense model may assist physical therapists to understand the broader sense-making processes involved in the fear-avoidance cycle, and how they can be altered to facilitate fear reduction by applying strategies established in the behavioral medicine literature. J Orthop Sports Phys Ther 2017;47(9):628-636. Epub 13 Jul 2017. doi:10.2519/jospt.2017.7434.
Understanding Statistics - Cancer Statistics

Cancer.gov

Annual reports of U.S. cancer statistics including new cases, deaths, trends, survival, prevalence, lifetime risk, and progress toward Healthy People targets, plus statistical summaries for a number of common cancer types.
Characterizing Touch Using Pressure Data and Auto Regressive Models

PubMed Central

Laufer, Shlomi; Pugh, Carla M.; Van Veen, Barry D.

2014-01-01

Palpation plays a critical role in medical physical exams. Despite the wide range of exams, there are several reproducible and subconscious sets of maneuvers that are common to examination by palpation. Previous studies by our group demonstrated the use of manikins and pressure sensors for measuring and quantifying how physicians palpate during different physical exams. In this study we develop mathematical models that describe some of these common maneuvers. Dynamic pressure data was measured using a simplified testbed and different autoregressive models were used to describe the motion of interest. The frequency, direction and type of motion used were identified from the models. We believe these models can a provide better understanding of how humans explore objects in general and more specifically give insights to understand medical physical exams. PMID:25570335
A Unified Pathophysiological Construct of Diabetes and its Complications.

PubMed

Schwartz, Stanley S; Epstein, Solomon; Corkey, Barbara E; Grant, Struan F A; Gavin Iii, James R; Aguilar, Richard B; Herman, Mary E

2017-09-01

Advances in understanding diabetes mellitus (DM) through basic and clinical research have helped clarify and reunify a disease state fragmented into numerous etiologies and subtypes. It is now understood that a common pathophysiology drives the diabetic state throughout its natural history and across its varied clinical presentations, a pathophysiology involving metabolic insults, oxidative damage, and vicious cycles that aggravate and intensify organ dysfunction and damage. This new understanding of the disease requires that we revisit existing diagnostics and treatment approaches, which were built upon outmoded assumptions. 'The Common Pathophysiologic Origins of Diabetes Mellitus and its Complications Construct' is presented as a more accurate, foundational, and translatable construct of DM that helps make sense of the hitherto ambiguous findings of long-term outcome studies. Copyright © 2017 Elsevier Ltd. All rights reserved.
Novel Paradigms for Dialysis Vascular Access: Downstream Vascular Biology–Is There a Final Common Pathway?

PubMed Central

2013-01-01

Summary Vascular access dysfunction is a major cause of morbidity and mortality in hemodialysis patients. The most common cause of vascular access dysfunction is venous stenosis from neointimal hyperplasia within the perianastomotic region of an arteriovenous fistula and at the graft-vein anastomosis of an arteriovenous graft. There have been few, if any, effective treatments for vascular access dysfunction because of the limited understanding of the pathophysiology of venous neointimal hyperplasia formation. This review will (1) describe the histopathologic features of hemodialysis access stenosis; (2) discuss novel concepts in the pathogenesis of neointimal hyperplasia development, focusing on downstream vascular biology; (3) highlight future novel therapies for treating downstream biology; and (4) discuss future research areas to improve our understanding of downstream biology and neointimal hyperplasia development. PMID:23990166
Thermodynamics, ecology and evolutionary biology: A bridge over troubled water or common ground?

NASA Astrophysics Data System (ADS)

Skene, Keith R.

2017-11-01

This paper addresses a key issue confronting ecological and evolutionary biology, namely the challenge of a cohesive approach to these fields given significant differences in the concepts and foundations of their study. Yet these two areas of scientific research are paramount in terms addressing the spatial and temporal dynamics and distribution of diversity, an understanding of which is needed if we are to resolve the current crisis facing the biosphere. The importance of understanding how nature responds to change is now of essential rather than of metaphysical interest as our planet struggles with increasing anthropogenic damage. Ecology and evolutionary biology can no longer remain disjointed. While some progress has been made in terms of synthetic thinking across these areas, this has often been in terms of bridge building, where thinking in one aspect is extended over to the other side. We review these bridges and the success or otherwise of such efforts. This paper then suggests that in order to move from a descriptive to a mechanistic understanding of the biosphere, we may need to re-evaluate our approach to the studies of ecology and evolutionary biology, finding a common denominator that will enable us to address the critical issues facing us, particularly in terms of understanding what drives change, what determines tempo and how communities function. Common ground, we argue, is essential if we are to comprehend how resilience operates in the natural world and how diversification can counter increasing extinction rates. This paper suggests that thermodynamics may provide a bridge between ecology and evolutionary biology, and that this will enable us to move forward with otherwise intractable problems.
Qualitative investigation of students' views about experimental physics

NASA Astrophysics Data System (ADS)

Hu, Dehui; Zwickl, Benjamin M.; Wilcox, Bethany R.; Lewandowski, H. J.

2017-12-01

This study examines students' reasoning surrounding seemingly contradictory Likert-scale responses within five items in the Colorado Learning Attitudes About Science Survey for Experimental Physics (E-CLASS). We administered the E-CLASS with embedded open-ended prompts, which asked students to provide explanations after making a Likert-scale selection. The quantitative scores on those items showed that our sample of the 216 students enrolled in first year and beyond first year physics courses demonstrated the same trends as previous national data. A qualitative analysis of students' open-ended responses was used to examine common reasoning patterns related to particular Likert-scale responses. When explaining responses to items regarding the role of experiments in confirming known results and also contributing to the growth of scientific knowledge, a common reasoning pattern suggested that confirming known results in a classroom experiment can help with understanding concepts. Thus, physics experiments contribute to students' personal scientific knowledge growth, while also confirming widely known results. Many students agreed that having correct formatting and making well-reasoned conclusions are the main goal for communicating experimental results. Students who focused on sections and formatting emphasized how it enables clear and efficient communication. However, very few students discussed the link between well-reasoned conclusions and effective scientific communication. Lastly, many students argued it was possible to complete experiments without understanding equations and physics concepts. The most common justification was that they could simply follow instructions to finish the lab without understanding. The findings suggest several implications for teaching physics laboratory courses, for example, incorporating some lab activities with outcomes that are unknown to the students might have a significant impact on students' understanding of experiments as an important approach for developing scientific knowledge.
Rock Climbing Injuries: Acute and Chronic Repetitive Trauma.

PubMed

Chang, Connie Y; Torriani, Martin; Huang, Ambrose J

2016-01-01

Rock climbing has increased in popularity as a sport, and specific injuries related to its practice are becoming more common. Chronic repetitive injuries are more common than acute injuries, although acute injuries tend to be more severe. We review both acute and chronic upper and lower extremity injuries. Understanding the injury pattern in rock climbers is important for accurate diagnosis. Copyright © 2015 Mosby, Inc. All rights reserved.
Overhead throwing injuries of the shoulder and elbow.

PubMed

Anderson, Mark W; Alford, Bennett A

2010-11-01

Injuries to the shoulder and elbow are common in athletes involved in sporting activities that require overhead motion of the arm. An understanding of the forces involved in the throwing motion, the anatomic structures most at risk, and the magnetic resonance imaging appearances of the most common associated injuries can help to improve diagnostic accuracy when interpreting imaging studies in these patients. Copyright © 2010 Elsevier Inc. All rights reserved.
CrossTalk: The Journal of Defense Software Engineering. Volume 23, Number 2, March/April 2010

DTIC Science & Technology

2010-04-01

SDLC phase. 4. Developing secure software depends on understanding the operational con- text in which it will be used. This con- text includes... its development . BSI leverages the Common Weakness Enumeration (CWE) and the Common Attack Pattern Enumeration and Classification (CAPEC) efforts. To...system integrators providing sys- tems (both IT and warfighting) to the Concept Refinement Technology Development System Development and
Pain management in older adults.

PubMed

Tracy, Bridget; Sean Morrison, R

2013-11-01

Chronic pain is prevalent among older adults but is underrecognized and undertreated. The approach to pain assessment and management in older adults requires an understanding of the physiology of aging, validated assessment tools, and common pain presentations among older adults. To identify the overall principles of pain management in older adults with a specific focus on common painful conditions and approaches to pharmacologic treatment. We searched PubMed for common pain presentations in older adults with heart failure, end-stage renal disease, dementia, frailty, and cancer. We also reviewed guidelines for pain management. Our review encompassed 2 guidelines, 10 original studies, and 22 review articles published from 2000 to the present. This review does not discuss nonpharmacologic treatments of pain. Clinical guidelines support the use of opioids in persistent nonmalignant pain. Opioids should be used in patients with moderate or severe pain or pain not otherwise controlled but with careful attention to potential toxic effects and half-life. In addition, clinical practice guidelines recommend use of oral nonsteroidal anti-inflammatory drugs with extreme caution and for defined, limited periods. An understanding of the basics of pain pathophysiology, assessment, pharmacologic management, and a familiarity with common pain presentations will allow clinicians to effectively manage pain for older adults. © 2013 Elsevier HS Journals, Inc. All rights reserved.
The dual impact of ecology and management on social incentives in marine common-pool resource systems.

PubMed

Klein, E S; Barbier, M R; Watson, J R

2017-08-01

Understanding how and when cooperative human behaviour forms in common-pool resource systems is critical to illuminating social-ecological systems and designing governance institutions that promote sustainable resource use. Before assessing the full complexity of social dynamics, it is essential to understand, concretely and mechanistically, how resource dynamics and human actions interact to create incentives and pay-offs for social behaviours. Here, we investigated how such incentives for information sharing are affected by spatial dynamics and management in a common-pool resource system. Using interviews with fishermen to inform an agent-based model, we reveal generic mechanisms through which, for a given ecological setting characterized by the spatial dynamics of the resource, the two 'human factors' of information sharing and management may heterogeneously impact various members of a group for whom theory would otherwise predict the same strategy. When users can deplete the resource, these interactions are further affected by the management approach. Finally, we discuss the implications of alternative motivations, such as equity among fishermen and consistency of the fleet's output. Our results indicate that resource spatial dynamics, form of management and level of depletion can interact to alter the sociality of people in common-pool resource systems, providing necessary insight for future study of strategic decision processes.
Genetic basis of hearing loss in Spanish, Hispanic and Latino populations.

PubMed

Mittal, Rahul; Patel, Amit P; Nguyen, Desiree; Pan, Debbie R; Jhaveri, Vasanti M; Rudman, Jason R; Dharmaraja, Arjuna; Yan, Denise; Feng, Yong; Chapagain, Prem; Lee, David J; Blanton, Susan H; Liu, Xue Zhong

2018-03-20

Hearing loss (HL) is the most common neurosensory disorder affecting humans. The screening, prevention and treatment of HL require a better understanding of the underlying molecular mechanisms. Genetic predisposition is one of the most common factors that leads to HL. Most HL studies include few Spanish, Hispanic and Latino participants, leaving a critical gap in our understanding about the prevalence, impact, unmet health care needs, and genetic factors associated with hearing impairment among Spanish, Hispanic and Latino populations. The few studies which have been performed show that the gene variants commonly associated with HL in non-Spanish and non-Hispanic populations are infrequently responsible for hearing impairment in Spanish as well as Hispanic and Latino populations (hereafter referred to as Hispanic). To design effective screening tools to detect HL in Spanish and Hispanic populations, studies must be conducted to determine the gene variants that are most commonly associated with hearing impairment in this racial/ethnic group. In this review article, we summarize gene variants and loci associated with HL in Spanish and Hispanic populations. Identifying new genetic variants associated with HL in Spanish and Hispanic populations will pave the way to develop effective screening tools and therapeutic strategies for HL. Copyright © 2018 Elsevier B.V. All rights reserved.
Understanding cancer staging

MedlinePlus

... detailed information about the cancer stage. TNM Staging System The most common system for staging cancer in ... urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows ...

Writing Research Reports.

PubMed

Sessler, Daniel I; Shafer, Steven

2018-01-01

Clear writing makes manuscripts easier to understand. Clear writing enhances research reports, increasing clinical adoption and scientific impact. We discuss styles and organization to help junior investigators present their findings and avoid common errors.
Pollen

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Ozone

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Guide to Understanding Pfeiffer Syndrome

MedlinePlus

... sockets (orbits). Approximately 50% of children with Pfeiffer syndrome have some form of hearing loss secondary to an abnormally small ear canal and middle ear. Dental problems are also common. Visual problems ...
Cardiometabolic Risks in Polycystic Ovary Syndrome: Non-Traditional Risk Factors and the Impact of Obesity.

PubMed

Chiu, Wei-Ling; Boyle, Jacqueline; Vincent, Amanda; Teede, Helena; Moran, Lisa J

2017-01-01

Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the pathophysiology, exacerbating hyperinsulinaemia and hyperandrogenism, leading to recommended first-line lifestyle intervention. Significant traditional and non-traditional risk factors are implicated in PCOS in addition to obesity-exacerbated cardiometabolic risks and are explored in this review to promote the understanding of this common metabolic and reproductive condition. © 2016 S. Karger AG, Basel.
Network geometry inference using common neighbors

NASA Astrophysics Data System (ADS)

Papadopoulos, Fragkiskos; Aldecoa, Rodrigo; Krioukov, Dmitri

2015-08-01

We introduce and explore a method for inferring hidden geometric coordinates of nodes in complex networks based on the number of common neighbors between the nodes. We compare this approach to the HyperMap method, which is based only on the connections (and disconnections) between the nodes, i.e., on the links that the nodes have (or do not have). We find that for high degree nodes, the common-neighbors approach yields a more accurate inference than the link-based method, unless heuristic periodic adjustments (or "correction steps") are used in the latter. The common-neighbors approach is computationally intensive, requiring O (t4) running time to map a network of t nodes, versus O (t3) in the link-based method. But we also develop a hybrid method with O (t3) running time, which combines the common-neighbors and link-based approaches, and we explore a heuristic that reduces its running time further to O (t2) , without significant reduction in the mapping accuracy. We apply this method to the autonomous systems (ASs) Internet, and we reveal how soft communities of ASs evolve over time in the similarity space. We further demonstrate the method's predictive power by forecasting future links between ASs. Taken altogether, our results advance our understanding of how to efficiently and accurately map real networks to their latent geometric spaces, which is an important necessary step toward understanding the laws that govern the dynamics of nodes in these spaces, and the fine-grained dynamics of network connections.
Alkaptonuria: An example of a "fundamental disease"--A rare disease with important lessons for more common disorders.

PubMed

Gallagher, James A; Dillon, Jane P; Sireau, Nicolas; Timmis, Oliver; Ranganath, Lakshminarayan R

2016-04-01

"Fundamental diseases" is a term introduced by the charity Findacure to describe rare genetic disorders that are gateways to understanding common conditions and human physiology. The concept that rare diseases have important lessons for biomedical science has been recognised by some of the great figures in the history of medical research, including Harvey, Bateson and Garrod. Here we describe some of the recently discovered lessons from the study of the iconic genetic disease alkaptonuria (AKU), which have shed new light on understanding the pathogenesis of osteoarthritis. In AKU, ochronotic pigment is deposited in cartilage when collagen fibrils become susceptible to attack by homogentisic acid (HGA). When HGA binds to collagen, cartilage matrix becomes stiffened, resulting in the aberrant transmission of loading to underlying subchondral bone. Aberrant loading leads to the formation of pathophysiological structures including trabecular excrescences and high density mineralised protrusions (HDMPs). These structures initially identified in AKU have subsequently been found in more common osteoarthritis and appear to play a role in joint destruction in both diseases. Copyright © 2016 Elsevier Ltd. All rights reserved.
Magnitude knowledge: the common core of numerical development.

PubMed

Siegler, Robert S

2016-05-01

The integrated theory of numerical development posits that a central theme of numerical development from infancy to adulthood is progressive broadening of the types and ranges of numbers whose magnitudes are accurately represented. The process includes four overlapping trends: (1) representing increasingly precisely the magnitudes of non-symbolic numbers, (2) connecting small symbolic numbers to their non-symbolic referents, (3) extending understanding from smaller to larger whole numbers, and (4) accurately representing the magnitudes of rational numbers. The present review identifies substantial commonalities, as well as differences, in these four aspects of numerical development. With both whole and rational numbers, numerical magnitude knowledge is concurrently correlated with, longitudinally predictive of, and causally related to multiple aspects of mathematical understanding, including arithmetic and overall math achievement. Moreover, interventions focused on increasing numerical magnitude knowledge often generalize to other aspects of mathematics. The cognitive processes of association and analogy seem to play especially large roles in this development. Thus, acquisition of numerical magnitude knowledge can be seen as the common core of numerical development. © 2016 John Wiley & Sons Ltd.
Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

PubMed Central

Goedert, Michel; Ghetti, Bernardino; Spillantini, Maria Grazia

2012-01-01

Frontotemporal dementia (FTD) comprises a group of behavioral, language, and movement disorders. On the basis of the nature of the characteristic protein inclusions, frontotemporal lobar degeneration (FTLD) can be subdivided into the common FTLD-tau and FTLD-TDP as well as the less common FTLD-FUS and FTLD-UPS. Approximately 10% of cases of FTD are inherited in an autosomal-dominant manner. Mutations in seven genes cause FTD, with those in tau (MAPT), chromosome 9 open reading frame 72 (C9ORF72), and progranulin (GRN) being the most common. Mutations in MAPT give rise to FTLD-tau and mutations in C9ORF72 and GRN to FTLD-TDP. The other four genes are transactive response–DNA binding protein-43 (TARDBP), fused in sarcoma (FUS), valosin-containing protein (VCP), and charged multivesicular body protein 2B (CHMP2B). Mutations in TARDBP and VCP give rise to FTLD-TDP, mutations in FUS to FTLD-FUS, and mutations in CHMP2B to FTLD-UPS. The discovery that mutations in MAPT cause neurodegeneration and dementia has important implications for understanding Alzheimer disease. PMID:22355793
Impact of excipient interactions on solid dosage form stability.

PubMed

Narang, Ajit S; Desai, Divyakant; Badawy, Sherif

2012-10-01

Drug-excipient interactions in solid dosage forms can affect drug product stability in physical aspects such as organoleptic changes and dissolution slowdown, or chemically by causing drug degradation. Recent research has allowed the distinction in chemical instability resulting from direct drug-excipient interactions and from drug interactions with excipient impurities. A review of chemical instability in solid dosage forms highlights common mechanistic themes applicable to multiple degradation pathways. These common themes include the role of water and microenvironmental pH. In addition, special aspects of solid-state reactions with excipients and/or excipient impurities add to the complexity in understanding and modeling reaction pathways. This paper discusses mechanistic basis of known drug-excipient interactions with case studies and provides an overview of common underlying themes. Recent developments in the understanding of degradation pathways further impact methodologies used in the pharmaceutical industry for prospective stability assessment. This paper discusses these emerging aspects in terms of limitations of drug-excipient compatibility studies, emerging paradigms in accelerated stability testing, and application of mathematical modeling for prediction of drug product stability.
Case Study Research Methodology in Nursing Research.

PubMed

Cope, Diane G

2015-11-01

Through data collection methods using a holistic approach that focuses on variables in a natural setting, qualitative research methods seek to understand participants' perceptions and interpretations. Common qualitative research methods include ethnography, phenomenology, grounded theory, and historic research. Another type of methodology that has a similar qualitative approach is case study research, which seeks to understand a phenomenon or case from multiple perspectives within a given real-world context.
Muscle fatigue: general understanding and treatment

PubMed Central

Wan, Jing-jing; Qin, Zhen; Wang, Peng-yuan; Sun, Yang; Liu, Xia

2017-01-01

Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and describe potential therapies for muscle fatigue, we summarize studies on muscle fatigue, including topics such as the sequence of events observed during force production, in vivo fatigue-site evaluation techniques, diagnostic markers and non-specific but effective treatments. PMID:28983090
Causes of the "I Can Understand English but I Can't Speak" Syndrome in Turkey

ERIC Educational Resources Information Center

Coskun, Abdullah

2016-01-01

The saying "I can understand English but I can't speak" is so commonly used by Turkish people that it would be fair to state that not being able to speak English has almost become a syndrome in society. This study delves into the causes of this syndrome. In two state high schools, 293 high school students filled out a questionnaire…
"My Papa's Waltz" as a Problem in Pedagogy.

ERIC Educational Resources Information Center

Barnard, Ann

1991-01-01

Maintains that, when students interpret a poem differently from their teachers, an opportunity opens for a common ground of understanding that can enrich the relationship between text and reader. (RS)
Parkinson's Disease

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Airway Clearance Techniques (ACTs)

MedlinePlus Videos and Cool Tools

... What Are Germs? Traveling With CF Preparing to Travel In Transit and at the Destination Special Considerations ... Appeals Glossary of Common Health Insurance Terms Understanding Travel Insurance Research X close About Our Research The ...
18 CFR 385.1303 - Conferences (Rule 1303).

Code of Federal Regulations, 2010 CFR

2010-04-01

... conferences are the means most often used to enable commissions to work together to promote good regulation, affording means whereby common understandings may be reached, and the imposition of inconsistent or...
18 CFR 385.1303 - Conferences (Rule 1303).

Code of Federal Regulations, 2011 CFR

2011-04-01

... conferences are the means most often used to enable commissions to work together to promote good regulation, affording means whereby common understandings may be reached, and the imposition of inconsistent or...
Understanding the cost of dermatologic care: A survey study of dermatology providers, residents, and patients.

PubMed

Steen, Aaron J; Mann, Julianne A; Carlberg, Valerie M; Kimball, Alexa B; Musty, Michael J; Simpson, Eric L

2017-04-01

The American Academy of Dermatology recommends dermatologists understand the costs of dermatologic care. This study sought to measure dermatology providers' understanding of the cost of dermatologic care and how those costs are communicated to patients. We also aimed to understand the perspectives of patients and dermatological trainees on how cost information enters into the care they receive or provide. Surveys were systematically developed and distributed to 3 study populations: dermatology providers, residents, and patients. Response rates were over 95% in all 3 populations. Dermatology providers and residents consistently underestimated the costs of commonly recommended dermatologic medications but accurately predicted the cost of common dermatologic procedures. Dermatology patients preferred to know the cost of procedures and medications, even when covered by insurance. In this population, the costs of dermatologic medications frequently interfered with patients' ability to properly adhere to prescribed regimens. The surveyed population was limited to the northwestern United States and findings may not be generalizable. Cost estimations were based on average reimbursement rates, which vary by insurer. Improving dermatology providers' awareness and communication of the costs of dermatologic care might enhance medical decision-making, improve adherence and outcomes, and potentially reduce overall health care expenditures. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Numbers, scale and symbols: the public understanding of nanotechnology

NASA Astrophysics Data System (ADS)

Batt, Carl A.; Waldron, Anna M.; Broadwater, Natalie

2008-10-01

Nanotechnology will be an increasing part of the everyday lives of most people in the world. There is a general recognition that few people understand the implications of the technology, the technology itself or even the definition of the word. This lack of understanding stems from a lack of knowledge about science in general but more specifically difficulty in grasping the size scale and symbolism of nanotechnology. A potential key to informing the general public is establishing the ability to comprehend the scale of nanotechnology. Transitioning from the macro to the nanoscale seems to require an ability to comprehend scales of one-billion. Scaling is a skill not common in most individuals and tests of their ability to extrapolate size based upon scaling a common object demonstrates that most individuals cannot scale to the extent needed to make the transition to nanoscale. Symbolism is another important vehicle to providing the general public with a basis to understand the concepts of nanotechnology. With increasing age, individuals are able to draw representations of atomic scale objects, but these tend to be iconic and the different representations not easily translated. Ball and stick models are most recognized by the public, which provides an opportunity to present not only useful symbolism but also a reference point for the atomic scale.

Understanding Motivations to Participate in an Observational Research Study: Why do Patients Enroll?

PubMed Central

Soule, Michael C.; Beale, Eleanor E.; Suarez, Laura; Beach, Scott R.; Mastromauro, Carol A.; Celano, Christopher M; Moore, Shannon V; Huffman, Jeff C.

2016-01-01

By understanding common motivations for participating in observational research studies, clinicians may better understand the perceived benefits of research participation from their clients’ perspective. We enrolled 164 cardiac patients in a study about the effects of gratitude and optimism. Two weeks post-enrollment, participants completed a four-item questionnaire regarding motivations for study enrollment. Altruistic motivation ranked highest, while intellectual, health-related, and financial motivations rated lower. Four subgroups of participants emerged, each with distinct characteristics and different priorities for participating. These findings may help front-line clinicians to understand which motivations for participation apply to their clients who enroll in non-treatment-based research projects. PMID:26933943
Scaling of theory-of-mind understandings in Chinese children.

PubMed

Wellman, Henry M; Fang, Fuxi; Liu, David; Zhu, Liqi; Liu, Guoxiong

2006-12-01

Prior research demonstrates that understanding of theory of mind develops at different paces in children raised in different cultures. Are these differences simply differences in timing, or do they represent different patterns of cultural learning? That is, to what extent are sequences of theory-of-mind understanding universal, and to what extent are they culture-specific? We addressed these questions by using a theory-of-mind scale to examine performance of 140 Chinese children living in Beijing and to compare their performance with that of 135 English-speaking children living in the United States and Australia. Results reveal a common sequence of understanding, as well as sociocultural differences in children's developing theories of mind.
Systems genetics approaches to understand complex traits

PubMed Central

Civelek, Mete; Lusis, Aldons J.

2014-01-01

Systems genetics is an approach to understand the flow of biological information that underlies complex traits. It uses a range of experimental and statistical methods to quantitate and integrate intermediate phenotypes, such as transcript, protein or metabolite levels, in populations that vary for traits of interest. Systems genetics studies have provided the first global view of the molecular architecture of complex traits and are useful for the identification of genes, pathways and networks that underlie common human diseases. Given the urgent need to understand how the thousands of loci that have been identified in genome-wide association studies contribute to disease susceptibility, systems genetics is likely to become an increasingly important approach to understanding both biology and disease. PMID:24296534
Racial Influences of Uveitic Glaucoma: Consolidation of Current Knowledge of Diagnosis and Treatment.

PubMed

Gregory, Anthony C; Zhang, Matthew M; Rapoport, Yuna; Ling, Jeanie D; Kuchtey, Rachel W

2016-01-01

The etiology, frequency, manifestation, and treatment of uveitis and uveitic glaucoma are commonly influenced by race. This study aims to review the effect of race on the diagnosis and treatment of patients with common diseases of uveitis that may develop into glaucoma. Race affects the presentation and prevalence of uveitis. Sarcoidosis, for example, is more common in Blacks than in Whites in the United States. Furthermore, Blacks more commonly have anterior segment involvement, while Whites more commonly have posterior segment involvement. In addition, treatments-such as steroid implants and trabeculectomy-in the setting of uveitis and uveitic glaucoma may have higher risk of failure in Black patients. Over the last half-century, we have increased our understanding of the role of race in uveitis and uveitic glaucoma. Major gaps remain and further study is needed.
The advance of technology and the scientific commons.

PubMed

Nelson, Richard R

2003-08-15

The advance of technology proceeds through an evolutionary process, with many different new departures in competition with each other and with prevailing practice, and with ex-post selection determining the winners and losers. In modern times what gives power to the process is the strong base of scientific and technological understanding and technique that guides the efforts of those seeking to advance the technology. Most of that base is part of a commons open to all who have expertise in a field. The proprietary aspects of technology traditionally have comprised a small topping on the commons. But recently parts of the commons have become privatized. While the justification for the policies and actions that have spurred privatization of the commons is that this will spur technological progress, the argument here is that the result can be just the opposite.
The quasiparticle zoo

NASA Astrophysics Data System (ADS)

Venema, Liesbeth; Verberck, Bart; Georgescu, Iulia; Prando, Giacomo; Couderc, Elsa; Milana, Silvia; Maragkou, Maria; Persechini, Lina; Pacchioni, Giulia; Fleet, Luke

2016-12-01

Quasiparticles are an extremely useful concept that provides a more intuitive understanding of complex phenomena in many-body physics. As such, they appear in various contexts, linking ideas across different fields and supplying a common language.
Genetics Home Reference: bipolar disorder

MedlinePlus

... with other common mental health disorders, such as schizophrenia . Understanding the genetics of bipolar disorder and other ... anxiety, and psychotic disorders (such as depression or schizophrenia ). These disorders may run in families in part ...
Electric & Magnetic Fields

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Allergens and Irritants

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Bisphenol A (BPA)

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
College Depression: What Parents Need to Know

MedlinePlus

Healthy Lifestyle Tween and teen health College depression is a common problem. Understand why the transition to college makes young adults vulnerable to depression — and what you can do about it. ...
Documentation to the NCES Common Core of Data Local Education Agency Universe Survey: School Year 2011-12. Provisional Version 1a. NCES 2014-035

ERIC Educational Resources Information Center

Keaton, Patrick

2014-01-01

This documentation is for the provisional version 1a file of the National Center for Education Statistics' (NCES) Common Core of Data (CCD) Local Education Agency (LEA) Universe Survey for SY 2011-12. It contains a brief description of the data collection, along with information required to understand and access the data file. The CCD is a…
Documentation to the NCES Common Core of Data Public Elementary/Secondary School Universe Survey: School Year 2011-12. Provisional Version 1a. NCES 2014-100

ERIC Educational Resources Information Center

Keaton, Patrick

2013-01-01

The documentation for this provisional version 1a file of the National Center for Education Statistics' (NCES) Common Core of Data (CCD) Public Elementary/Secondary School Universe Survey for SY 2011-12, contains a brief description of the data collection, along with information required to understand and access the data file. The SY 2011-12…
Auricular Therapy for Treatment of Musculoskeletal Pain in the Setting of Deployed Military Personnel: A Randomized Trial

DTIC Science & Technology

2016-12-01

unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Musculoskeletal injuries resulting in pain are one of the most common reasons for disability and missed...Musculoskeletal injuries resulting in pain are one of the most common reasons for disability and missed duty among military personnel. Preliminary research...activities, for the purpose of enhancing public understanding and increasing interest in learning and careers in science, technology, and the
Motivations for adolescent self-harm and the implications for mental health nurses.

PubMed

Doyle, L; Sheridan, A; Treacy, M P

2017-03-01

WHAT IS KNOWN ON THE SUBJECT?: Self-harm is a relatively common occurrence in adolescents; however, there remains a lack of understanding about the motivations behind adolescent self-harm, and this poor understanding can have a negative impact on how mental health professionals respond to young people who self-harm. WHAT DOES THIS PAPER ADD TO EXISTING KNOWLEDGE?: This paper identifies the reasons for self-harm in a community sample of young people and finds that the functions of self-harm differ for different people and that there may be multiple reasons for self-harm. Findings provide support for the affect-regulation model of self-harm which states that young people self-harm to regulate how they are feeling, but provides little support for the interpersonal influence model which proposes that self-harm is an attempt to influence how other people respond to them. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: Self-harm for most young people serves at least one specific function and is an indication of distress. There is a requirement for a non-pathologizing response towards young people who self-harm; self-harm should be understood as a meaningful behaviour rather than a symptom of an illness. Mental health nurses need to understand the multiple functions of self-harm. A better understanding of the individualized meaning behind self-harm can positively impact on attitudes towards young people who self-harm and provide for improved mental health service provision. Introduction Although self-harm is a relatively common occurrence in adolescents, there is a lack of understanding about the motivations behind it. A poor understanding of self-harm contributes to negative perceptions about those who self-harm and a poor healthcare experience. Aim & Methods This study identifies motivations behind self-harm in school-based adolescents using a cross-sectional survey. Motivations behind self-harm were elicited using a scale and open-ended responses. Results Of the 856 adolescents who completed the survey across 11 postprimary schools, 103 reported a history of self-harm. The most commonly endorsed reason for self-harm was to 'get relief from a terrible state of mind' (79%). Open-ended responses were consistent with scale responses with most reporting that they self-harmed to relieve distressing emotions. Discussion Findings provide support for the affect-regulation model of self-harm with support also demonstrated for the self-punishment and antidissociation models. There was little support for the interpersonal influence model suggesting that the commonly held belief that self-harm is attention-seeking is one attributed by others to young people, and not widely reported by young people themselves. Implications for practice Mental health services need to be responsive to the needs of young people who self-harm which requires eliciting and understanding the individual and multiple meanings behind self-harm to best inform treatment options. © 2017 John Wiley & Sons Ltd.
Research philosophy: towards an understanding.

PubMed

Crossan, Frank

2003-01-01

In this paper, Frank Crossan argues that the distinction between quantitative and qualitative philosophies and research methods is sometimes overstated, and that triangulation of methods in contemporary research is common. It is, therefore, important to understand the strengths and weaknesses of each approach, and this paper aims to provide the novice researcher with a basis for developing that understanding. A descriptive analysis of the philosophies of positivism and post-positivist thinking in relation to research methodology is presented both as an introduction to the philosophical basis of research, and as a sound basis from which to discuss the 'quantitative-qualitative' debate.
Educational Stress: Sources, Reactions, Preventions.

ERIC Educational Resources Information Center

Kaiser, Jeffrey S.; Polczynski, James J.

1982-01-01

Effects of stress on educators and efforts to understand and cope with stress are discussed. Sources of stress, common reactions to stress, the effects of stress on educator performance, and suggested preventive methods are examined. (JN)
Cough Medicine: Understanding Your OTC Options

MedlinePlus

... and expectorants. A common antitussive is dextromethorphan (some brand names: Triaminic Cold and Cough, Robitussin Cough, Vicks ... expectorant available in OTC products is guaifenesin (2 brand names: Mucinex, Robitussin Chest Congestion). How do OTC ...
Transit performance measures in California.

DOT National Transportation Integrated Search

2016-04-01

This research is the result of a California Department of Transportation (Caltrans) request to assess the most commonly : available transit performance measures in California. Caltrans wanted to understand performance measures and data used by : Metr...
Understanding Carbohydrates

MedlinePlus

... Honor Donation Donate by phone at 1-800-DIABETES (1-800-342-2383) Donate by mail Why Give? ... My Health Advisor Tools to Know Your Risk Diabetes Basics Symptoms Type 1 Type 2 Gestational Myths Statistics Common Terms Genetics ...

Incorporating Quality of Life Metrics in Interventional Oncology Practice.

PubMed

Li, David; Madoff, David C

2017-12-01

Interventional radiologists care for a large number of cancer patients with the breadth of palliative intent minimally invasive procedures that we provide. Understanding our meaningful impact on patients' quality of life is essential toward validating our role in the palliation of cancer patients. As such, it is critically important for interventional radiologists to understand common instruments used for the reporting of patient's quality of life measures. Common instruments used to measure pain and quality of life for cancer patients include the numerical rating scale, visual analog scale, brief pain inventory, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, and the Functional Assessment of Cancer Therapy. An ideal quality of life instrument should be a patient reported outcome measure across multiple domains (e.g., physical health, psychological, social), and be both validated and reliable.
Cystic Fibrosis and Its Management Through Established and Emerging Therapies.

PubMed

Spielberg, David R; Clancy, John P

2016-08-31

Cystic fibrosis (CF) is the most common life-shortening autosomal recessive disorder in the Caucasian population and occurs in many other ethnicities worldwide. The daily treatment burden is substantial for CF patients even when they are well, with numerous pharmacologic and physical therapies targeting lung disease requiring the greatest time commitment. CF treatments continue to advance with greater understanding of factors influencing long-term morbidity and mortality. In recent years, in-depth understanding of genetic and protein structure-function relationships has led to the introduction of targeted therapies for patients with specific CF genotypes. With these advances, CF has become a model of personalized or precision medicine. The near future will see greater access to targeted therapies for most patients carrying common mutations, which will mandate individualized bench-to-bedside methodologies for those with rare genotypes.
Shared vision and autonomous motivation vs. financial incentives driving success in corporate acquisitions

PubMed Central

Clayton, Byron C.

2015-01-01

Successful corporate acquisitions require its managers to achieve substantial performance improvements in order to sufficiently cover acquisition premiums, the expected return of debt and equity investors, and the additional resources needed to capture synergies and accelerate growth. Acquirers understand that achieving the performance improvements necessary to cover these costs and create value for investors will most likely require a significant effort from mergers and acquisitions (M&A) management teams. This understanding drives the common and longstanding practice of offering hefty performance incentive packages to key managers, assuming that financial incentives will induce in-role and extra-role behaviors that drive organizational change and growth. The present study debunks the assumptions of this common M&A practice, providing quantitative evidence that shared vision and autonomous motivation are far more effective drivers of managerial performance than financial incentives. PMID:25610406
Shared vision and autonomous motivation vs. financial incentives driving success in corporate acquisitions.

PubMed

Clayton, Byron C

2014-01-01

Successful corporate acquisitions require its managers to achieve substantial performance improvements in order to sufficiently cover acquisition premiums, the expected return of debt and equity investors, and the additional resources needed to capture synergies and accelerate growth. Acquirers understand that achieving the performance improvements necessary to cover these costs and create value for investors will most likely require a significant effort from mergers and acquisitions (M&A) management teams. This understanding drives the common and longstanding practice of offering hefty performance incentive packages to key managers, assuming that financial incentives will induce in-role and extra-role behaviors that drive organizational change and growth. The present study debunks the assumptions of this common M&A practice, providing quantitative evidence that shared vision and autonomous motivation are far more effective drivers of managerial performance than financial incentives.
The role of ethical principles in health care and the implications for ethical codes.

PubMed Central

Limentani, A E

1999-01-01

A common ethical code for everybody involved in health care is desirable, but there are important limitations to the role such a code could play. In order to understand these limitations the approach to ethics using principles and their application to medicine is discussed, and in particular the implications of their being prima facie. The expectation of what an ethical code can do changes depending on how ethical properties in general are understood. The difficulties encountered when ethical values are applied reactively to an objective world can be avoided by seeing them as a more integral part of our understanding of the world. It is concluded that an ethical code can establish important values and describe a common ethical context for health care but is of limited use in solving new and complex ethical problems. PMID:10536764
Consensus Paper: Pathological Mechanisms Underlying Neurodegeneration in Spinocerebellar Ataxias

PubMed Central

Matilla-Dueñas, A.; Ashizawa, T.; Brice, A.; Magri, S.; McFarland, K. N.; Pandolfo, M.; Pulst, S. M.; Riess, O.; Rubinsztein, D. C.; Schmidt, J.; Schmidt, T.; Scoles, D. R.; Stevanin, G.; Taroni, F.; Underwood, B. R.; Sánchez, I.

2014-01-01

Intensive scientific research devoted in the recent years to understand the molecular mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new pathways and targets providing new insights and a better understanding of the molecular pathogenesis in these diseases. In this consensus manuscript, the authors discuss their current views on the identified molecular processes causing or modulating the neurodegenerative phenotype in spinocerebellar ataxias with the common opinion of translating the new knowledge acquired into candidate targets for therapy. The following topics are discussed: transcription dysregulation, protein aggregation, autophagy, ion channels, the role of mitochondria, RNA toxicity, modulators of neurodegeneration and current therapeutic approaches. Overall point of consensus includes the common vision of neurodegeneration in SCAs as a multifactorial, progressive and reversible process, at least in early stages. Specific points of consensus include the role of the dysregulation of protein folding, transcription, bioenergetics, calcium handling and eventual cell death with apoptotic features of neurons during SCA disease progression. Unresolved questions include how the dysregulation of these pathways triggers the onset of symptoms and mediates disease progression since this understanding may allow effective treatments of SCAs within the window of reversibility to prevent early neuronal damage. Common opinions also include the need for clinical detection of early neuronal dysfunction, for more basic research to decipher the early neurodegenerative process in SCAs in order to give rise to new concepts for treatment strategies and for the translation of the results to preclinical studies and, thereafter, in clinical practice. PMID:24307138
Evolutionary tree design: An exploratory study of the influence of linear versus branching format on visitors' interpretation and understanding across age groups

NASA Astrophysics Data System (ADS)

MacDonald, Teresa Elise

This exploratory study sought to investigate the influence of tree graphic design---specifically linear versus branching depictions of taxa---on visitors in three different age groups (aged 11-13, 14-18, adults) interpretation and understanding using a multiple-case study strategy. The findings from this research indicate that linear and branched depictions elicit qualitatively different narratives and explanations about the relationships between the taxa in all age groups. Branched tree graphics support scientifically appropriate explanations of evolutionary relationships, i.e. that taxa are related via shared or common ancestry; while linear representations reinforce intuitive interpretations of ancestor-descendant or anagenic relationships. Furthermore, differences in the language used for linear and branched trees suggests that there is a spectrum within an analogy of developmental change that is thought to serve as a transitional concept between intuitive and scientific understanding--with 'evolved from' for branched depictions of taxa representing a shift towards an interpretation of shared ancestry rather than an individual transformation from one thing into another. In addition, branched graphics appear to support the correct reading and interpretation of shared or common ancestry in tree diagrams. Mixed reasoning was common and overall reasoning patterns were broadly similar among participants in all age groups, however, older youth (aged 14 to 18) and adults often provided more detail in their explanations and sometimes included references to evolutionary ideas such as variation, inheritance and selection.
Mapping Common Aphasia Assessments to Underlying Cognitive Processes and Their Neural Substrates.

PubMed

Lacey, Elizabeth H; Skipper-Kallal, Laura M; Xing, Shihui; Fama, Mackenzie E; Turkeltaub, Peter E

2017-05-01

Understanding the relationships between clinical tests, the processes they measure, and the brain networks underlying them, is critical in order for clinicians to move beyond aphasia syndrome classification toward specification of individual language process impairments. To understand the cognitive, language, and neuroanatomical factors underlying scores of commonly used aphasia tests. Twenty-five behavioral tests were administered to a group of 38 chronic left hemisphere stroke survivors and a high-resolution magnetic resonance image was obtained. Test scores were entered into a principal components analysis to extract the latent variables (factors) measured by the tests. Multivariate lesion-symptom mapping was used to localize lesions associated with the factor scores. The principal components analysis yielded 4 dissociable factors, which we labeled Word Finding/Fluency, Comprehension, Phonology/Working Memory Capacity, and Executive Function. While many tests loaded onto the factors in predictable ways, some relied heavily on factors not commonly associated with the tests. Lesion symptom mapping demonstrated discrete brain structures associated with each factor, including frontal, temporal, and parietal areas extending beyond the classical language network. Specific functions mapped onto brain anatomy largely in correspondence with modern neural models of language processing. An extensive clinical aphasia assessment identifies 4 independent language functions, relying on discrete parts of the left middle cerebral artery territory. A better understanding of the processes underlying cognitive tests and the link between lesion and behavior may lead to improved aphasia diagnosis, and may yield treatments better targeted to an individual's specific pattern of deficits and preserved abilities.
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cieri, Domenico; Brini, Marisa; Calì, Tito

The selective cell loss in the ventral component of the substantia nigra pars compacta and the presence of alpha-synuclein (α-syn)-rich intraneuronal inclusions called Lewy bodies are the pathological hallmarks of Parkinson's disease (PD), the most common motor system disorder whose aetiology remains largely elusive. Although most cases of PD are idiopathic, there are rare familial forms of the disease that can be traced to single gene mutations that follow Mendelian inheritance pattern. The study of several nuclear encoded proteins whose mutations are linked to the development of autosomal recessive and dominant forms of familial PD enhanced our understanding of biochemicalmore » and cellular mechanisms contributing to the disease and suggested that many signs of neurodegeneration result from compromised mitochondrial function. Here we present an overview of the current understanding of PD-related mitochondrial dysfunction including defects in bioenergetics and Ca{sup 2+} homeostasis, mitochondrial DNA mutations, altered mitochondrial dynamics and autophagy. We emphasize, in particular, the convergence of many “apparently” different pathways towards a common route involving mitochondria. Understanding whether mitochondrial dysfunction in PD represents the cause or the consequence of the disease is challenging and will help to define the pathogenic processes at the basis of the PD onset and progression. - Highlights: • Mitochondrial dysfunctions are a common feature of neurodegenerative diseases. • Many familial PD related proteins ensure mitochondrial function. • Mutations in PD genes differently affect mitochondria related activities.« less
The genome revolution and its role in understanding complex diseases.

PubMed

Hofker, Marten H; Fu, Jingyuan; Wijmenga, Cisca

2014-10-01

The completion of the human genome sequence in 2003 clearly marked the beginning of a new era for biomedical research. It spurred technological progress that was unprecedented in the life sciences, including the development of high-throughput technologies to detect genetic variation and gene expression. The study of genetics has become "big data science". One of the current goals of genetic research is to use genomic information to further our understanding of common complex diseases. An essential first step made towards this goal was by the identification of thousands of single nucleotide polymorphisms showing robust association with hundreds of different traits and diseases. As insight into common genetic variation has expanded enormously and the technology to identify more rare variation has become available, we can utilize these advances to gain a better understanding of disease etiology. This will lead to developments in personalized medicine and P4 healthcare. Here, we review some of the historical events and perspectives before and after the completion of the human genome sequence. We also describe the success of large-scale genetic association studies and how these are expected to yield more insight into complex disorders. We show how we can now combine gene-oriented research and systems-based approaches to develop more complex models to help explain the etiology of common diseases. This article is part of a Special Issue entitled: From Genome to Function. Copyright © 2014 Elsevier B.V. All rights reserved.
Emerging concepts in effector biology of plant-associated organisms.

PubMed

Hogenhout, Saskia A; Van der Hoorn, Renier A L; Terauchi, Ryohei; Kamoun, Sophien

2009-02-01

Plant-associated organisms secrete proteins and other molecules to modulate plant defense circuitry and enable colonization of plant tissue. Understanding the molecular function of these secreted molecules, collectively known as effectors, became widely accepted as essential for a mechanistic understanding of the processes underlying plant colonization. This review summarizes recent findings in the field of effector biology and highlights the common concepts that have emerged from the study of cellular plant pathogen effectors.
Recent advances in understanding and managing cystic fibrosis transmembrane conductance regulator dysfunction

PubMed Central

Alton, Eric W.F.W.

2015-01-01

Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians and has been extensively studied for many decades. The cystic fibrosis transmembrane conductance regulator gene was identified in 1989. It encodes a complex protein which has numerous cellular functions. Our understanding of cystic fibrosis pathophysiology and genetics is constantly expanding and being refined, leading to improved management of the disease and increased life expectancy in affected individuals. PMID:26097737
Common themes and differences in SAM recognition among SAM riboswitches

PubMed Central

Price, Ian R.; Grigg, Jason C.; Ke, Ailong

2014-01-01

The recent discovery of short cis-acting RNA elements termed riboswitches has caused a paradigm shift in our understanding of genetic regulatory mechanisms. The three distinct superfamilies of S-adenosyl-L-methionine (SAM) riboswitches are the most commonly found riboswitch classes in nature. These RNAs represent three independent evolutionary solutions to achieve specific SAM recognition. This review summarizes research on 1) modes of gene regulatory mechanisms, 2) common themes and differences in ligand recognition, and 3) ligand-induced conformational dynamics among SAM riboswitch families. The body of work on the SAM riboswitch families constitutes a useful primer to the topic of gene regulatory RNAs as a whole. PMID:24863160
Mapping rare and common causal alleles for complex human diseases

PubMed Central

Raychaudhuri, Soumya

2011-01-01

Advances in genotyping and sequencing technologies have revolutionized the genetics of complex disease by locating rare and common variants that influence an individual’s risk for diseases, such as diabetes, cancers, and psychiatric disorders. However, to capitalize on this data for prevention and therapies requires the identification of causal alleles and a mechanistic understanding for how these variants contribute to the disease. After discussing the strategies currently used to map variants for complex diseases, this Primer explores how variants may be prioritized for follow-up functional studies and the challenges and approaches for assessing the contributions of rare and common variants to disease phenotypes. PMID:21962507
Differential proteomics reveals the hallmarks of seed development in common bean (Phaseolus vulgaris L.).

PubMed

Parreira, J R; Bouraada, J; Fitzpatrick, M A; Silvestre, S; Bernardes da Silva, A; Marques da Silva, J; Almeida, A M; Fevereiro, P; Altelaar, A F M; Araújo, S S

2016-06-30

Common bean (Phaseolus vulgaris L.) is one of the most consumed staple foods worldwide. Little is known about the molecular mechanisms controlling seed development. This study aims to comprehensively describe proteome dynamics during seed development of common bean. A high-throughput gel-free proteomics approach (LC-MS/MS) was conducted on seeds at 10, 20, 30 and 40days after anthesis, spanning from late embryogenesis until desiccation. Of the 418 differentially accumulated proteins identified, 255 were characterized, most belonging to protein metabolism. An accumulation of proteins belonging to the MapMan functional categories of "protein", "glycolysis", "TCA", "DNA", "RNA", "cell" and "stress" were found at early seed development stages, reflecting an extensive metabolic activity. In the mid stages, accumulation of storage, signaling, starch synthesis and cell wall-related proteins stood out. In the later stages, an increase in proteins related to redox, protein degradation/modification/folding and nucleic acid metabolisms reflect that seed desiccation-resistance mechanisms were activated. Our study unveils new clues to understand the regulation of seed development mediated by post-translational modifications and maintenance of genome integrity. This knowledge enhances the understanding on seed development molecular mechanisms that may be used in the design and selection of common bean seeds with desired quality traits. Common bean (P. vulgaris) is an important source of proteins and carbohydrates worldwide. Despite the agronomic and economic importance of this pulse, knowledge on common bean seed development is limited. Herein, a gel-free high throughput methodology was used to describe the proteome changes during P. vulgaris seed development. Data obtained will enhance the knowledge on the molecular mechanisms controlling this grain legume seed development and may be used in the design and selection of common bean seeds with desired quality traits. Results may be extrapolated to other pulses. Copyright © 2016 Elsevier B.V. All rights reserved.
Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions

PubMed Central

Williams, Emily C.; Hahn, Judith A.; Saitz, Richard; Bryant, Kendall; Lira, Marlene C.; Samet, Jeffrey H.

2016-01-01

Alcohol use is common among people living with human immunodeficiency virus (HIV). In this narrative review, we describe literature regarding alcohol’s impact on transmission, care, co-infections and comorbidities that are common among people living with HIV (PLWH), as well as literature regarding interventions to address alcohol use and its influences among PLWH. This narrative review identifies alcohol use as a risk factor for HIV transmission, as well as a factor impacting the clinical manifestations and management of HIV. Alcohol use appears to have additive and potentially synergistic effects on common HIV-related comorbidities. We find that interventions to modify drinking and improve HIV-related risks and outcomes have had limited success to date, and we recommend research in several areas. Consistent with Office of AIDS Research/National Institutes of Health priorities, we suggest research to better understand how and at what levels alcohol influences comorbid conditions among PLWH, to elucidate the mechanisms by which alcohol use is impacting comorbidities, and to understand whether decreases in alcohol use improve HIV-relevant outcomes. This should include studies regarding whether state-of-the-art medications used to treat common co-infections are safe for PLWH who drink alcohol. We recommend that future research among PLWH include validated self-report measures of alcohol use and/or biological measurements, ideally both. Additionally, subgroup variation in associations should be identified to ensure that the risks of particularly vulnerable populations are understood. This body of research should serve as a foundation for a next generation of intervention studies to address alcohol use from transmission to treatment of HIV. Intervention studies should inform implementation efforts to improve provision of alcohol-related interventions and treatments for PLWH in healthcare settings. By making further progress on understanding how alcohol use affects PLWH in the era of HIV as a chronic condition, this research should inform how we can mitigate transmission, achieve viral suppression, avoid exacerbating common comorbidities of HIV and alcohol use and make progress toward the 90-90-90 goals for engagement in the HIV treatment cascade. PMID:27696523
Clinical coordination in accountable care organizations: A qualitative study.

PubMed

Lewis, Valerie A; Schoenherr, Karen; Fraze, Taressa; Cunningham, Aleen

2016-12-06

Accountable care organizations (ACOs) are becoming a common payment and delivery model. Despite widespread interest, little empirical research has examined what efforts or strategies ACOs are using to change care and reduce costs. Knowledge of ACOs' clinical efforts can provide important context for understanding ACO performance, particularly to distinguish arenas where ACOs have and have not attempted care transformation. The aim of the study was to understand ACOs' efforts to change clinical care during the first 18 months of ACO contracts. We conducted semistructured interviews between July and December 2013. Our sample includes ACOs that began performance contracts in 2012, including Medicare Shared Savings Program and Pioneer participants, stratified across key factors. In total, we conducted interviews with executives from 30 ACOs. Iterative qualitative analysis identified common patterns and themes. ACOs in the first year of performance contracts are commonly focusing on four areas: first, transforming primary care through increased access and team-based care; second, reducing avoidable emergency department use; third, strengthening practice-based care management; and fourth, developing new boundary spanner roles and activities. ACOs were doing little around transforming specialty care, acute and postacute care, or standardizing care across practices during the first 18 months of ACO performance contracts. Results suggest that cost reductions associated with ACOs in the first years of contracts may be related to primary care. Although in the long term many hope ACOs will achieve coordination across a wide array of care settings and providers, in the short term providers under ACO contracts are focused largely on primary care-related strategies. Our work provides a template of the common areas of clinical activity in the first years of ACO contracts, which may be informative to providers considering becoming an ACO. Further research will be needed to understand how these strategies are associated with performance.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
A practical review of the muscles of facial mimicry with special emphasis on the superficial musculoaponeurotic system.

PubMed

Hutto, Justin R; Vattoth, Surjith

2015-01-01

In this article, we elaborate a practical approach to superficial facial anatomy enabling easy identification of the facial mimic muscles by classifying them according to their shared common insertion sites. The facial mimic muscles are often difficult to identify on imaging. By tracing them from their common group insertion sites back to their individual origins as well as understanding key anatomic relationships, radiologists can more accurately identify these muscles.
From Data to Knowledge in Earth Science, Planetary Science, and Astronomy

NASA Technical Reports Server (NTRS)

Dobinson, Elaine R.; Jacob, Joseph C.; Yunck, Thomas P.

2004-01-01

This paper examines three NASA science data archive systems from the Earth, planetary, and astronomy domains, and discusses the various efforts underway to provide their science communities with not only better access to their holdings, but also with the services they need to interpret the data and understand their physical meaning. The paper identifies problems common to all three domains and suggests ways that common standards, technologies, and even implementations be leveraged to benefit each other.
Documentation for the NCES Common Core of Data National Public Education Financial Survey (NPEFS), School Year 2008-09 (Fiscal Year 2009). Revised File Version 1b. NCES 2011-330rev

ERIC Educational Resources Information Center

Cornman, Stephen Q.; Zhou, Lei; Nakamoto, Nanae

2012-01-01

This documentation is for the revised file (Version 1b) of the National Center for Education Statistics' (NCES) Common Core of Data (CCD) National Public Education Financial Survey (NPEFS) for school year 2008-2009, fiscal year 2009 (FY 09). It contains a brief description of the data collection along with information required to understand and…

77 FR 60910 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Streamlining...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-05

..., the Commenter asserts that, ``It defies common understanding of fairness to push burdens away from the... as establishing deadlines on both parties eliminates potentially open ended, back-and-forth...
Intercultural differences and communication at the end of life.

PubMed

Hallenbeck, J L

2001-06-01

Cross-cultural encounters at the end of life are common and can result in misunderstandings and conflicts. The primary care physician is ideally suited to facilitate communication that can promote understanding and conflict resolution.
Extracting geography from trade data

NASA Astrophysics Data System (ADS)

Li, Yuke; Wu, Tianhao; Marshall, Nicholas; Steinerberger, Stefan

2017-05-01

Understanding international trade is a fundamental problem in economics-one standard approach is via what is commonly called the "gravity equation", which predicts the total amount of trade Fi j between two countries i and j as
Environmental Health Topics from A to Z

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Understanding Collaborative Leadership in Theory and Practice

ERIC Educational Resources Information Center

Lawrence, Randee Lipson

2017-01-01

This final chapter provides a synthesis and analysis of the major themes in the previous chapters. Definitions of collaborative leadership are explored along with theoretical underpinnings, characteristics, and common themes. Implications for adult education are discussed.
Peer exchange for Southwestern states, May 7-10, 2013.

DOT National Transportation Integrated Search

2013-05-01

The objectives of the peer exchange were the following: : Create networks and open lines of communication. : Develop an understanding of product evaluation programs in other states. : Seek commonalities in research being done and challeng...
The Continuing Quest for Rationality in Curriculum Practice.

ERIC Educational Resources Information Center

Gay, Geneva

1979-01-01

Suggests that understanding different conceptual models of curriculum making will increase the effectiveness and rationality of the development process. Presents four commonly used models of curriculum development: empiricism, rationalism, pragmatism, and humanism. (Author/JM)
Ischemic Stroke: From Next Generation Sequencing and GWAS to Community Genomics?

PubMed

Black, Michael; Wang, Wenzhi; Wang, Wei

2015-08-01

Stroke is a major cause of mortality and morbidity in both the developed and developing world. Next generation sequencing (NGS) and multi-omics integrative biology research offer new opportunities in the way we research and understand stroke. These biotechnologies also signal a shift from genetics to genomics of stroke, which is highlighted in this review. Stroke is a focal neurological deficit resulting from disruption of the cerebral blood supply. There are two main types of common stroke, ischemic stroke (IS), which comprises 80% of cases, and hemorrhagic stroke (HS) that accounts for about 20% of cases. IS is a complex multi-factorial disease with multiple environmental and genomic determinants. We discuss here IS from genomics and bioinformatics perspectives, including the highlights of the genome wide association studies (GWAS), NGS progress to date, and exome studies. While both 'common variant, common disease' and 'rare variant, common disease' approaches need to be assessed in tandem, future studies into IS omics should also consider pedigree and/or community based sampling to take account of the complex diversity of IS genetics. We conclude by presenting an example of such community genomics research from China in an extended pedigree sample, and the ways in which the intersection of genomics and global society can usefully inform our understanding of IS pathophysiology and potential preventive medicine interventions in the future.
A Review of the Differences in Developmental, Psychiatric, and Medical Endophenotypes Between Males and Females with Autism Spectrum Disorder

PubMed Central

Rubenstein, Eric; Wiggins, Lisa D.; Lee, Li-Ching

2015-01-01

Autism spectrum disorder (ASD) is over four times more prevalent in males compared to females. Increased understanding of sex differences in ASD endophenotypes could add insight into possible etiologies and the assessment and management of the disorder. Consequently, the purpose of this review is to describe current literature regarding sex differences in the developmental, psychiatric, and medical endophenotypes of ASD in order to illustrate current knowledge and areas in need of further research. Our review found that repetitive behaviors and restricted interests are more common in males than females with ASD. Intellectual disability is more common in females than males with ASD. Attention to detail may be more common in males than females with ASD and epilepsy may be more common in females than males with ASD, although limited research in these areas prevent definitive conclusions from being drawn. There does not appear to be a sex difference in other developmental, psychiatric, and medical symptoms associated with ASD, or the research was contradictory or too sparse to establish a sex difference. Our review is unique in that it offers detailed discussion of sex differences in three major endophenotypes of ASD. Further research is needed to better understand why sex differences exist in certain ASD traits and to evaluate whether phenotypic sex differences are related to different pathways of development, assessment, and treatment of the disorder. PMID:26146472
Cancer understanding among Japanese students based on a nationwide survey.

PubMed

Sugisaki, Koshu; Ueda, Seiji; Monobe, Hirofumi; Yako-Suketomo, Hiroko; Eto, Takashi; Watanabe, Masaki; Mori, Ryoichi

2014-11-01

The objective of this study was to determine cancer understanding among Japanese primary and secondary school students. The study design was a cross-sectional nationwide survey using a self-administered questionnaire. The prefecture with the lowest student population was set to 1, and that with the highest student population was set to 18 for elementary schools and 19 for junior high and high schools based on the ratio of the student population. In this way, 213 elementary schools, 222 junior high schools, and 208 high schools were selected from all 47 prefectures in Japan, and questionnaires were sent to each school. The questionnaire listed the names of 15 cancers and asked respondents to choose one answer from three: "Never heard of," "Heard of/Don't understand," or "Heard of/Understand." Response rates for schools were 44.1 % (n = 94) for elementary schools, 46.4 % (n = 103) for junior high schools, and 55.8 % (n = 116) for high schools. A total of 8,876 questionnaires were used for the analysis. Our survey suggests that the most commonly understood types of cancer differed by grade, with lung cancer the most commonly understood in elementary school, leukemia in junior high schools, and breast cancer in high schools. Girls tended to demonstrate greater cancer understanding than boys, with particularly large differences by gender in rates of understanding of breast and uterine cancer at each assessed grade level. Here, we examined Japanese primary and secondary school students. Marked differences in cancer recognition by grade and gender suggest that educational efforts are needed at various grade levels and gender-specific cancer education. Further, more than 50 % of students at any school level were not familiar with most cancers. It suggests that cancer education is deficient.
Understanding novel language

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dejong, G.F.; Waltz, D.L.

1983-01-01

This paper treats in some detail the problem of designing mechanisms that will allow one to deal with two types of novel language: (1) text requiring scheme learning; and (2) the understanding of novel metaphorical use of verbs. Schema learning is addressed by four types of processes: scheme composition, secondary effect elevation, schema alteration, and volitionalization. The processing of novel metaphors depends on a decompositional analysis of verbs into event shape diagrams, along with a matching process that uses semantic marker-like information, to construct novel meaning structures. The examples described have been chosen to be types that occur commonly, somore » that rules that are needed to understand them can also be used to understand a much wider range of novel language. 38 references.« less
The theoretical root of Karl Jaspers’ General Psychopathology. Part 1: Reconsidering the influence of phenomenology and hermeneutics

PubMed Central

2013-01-01

The present paper investigates the methodology involved in Jaspers’ psychopathology and compares it with Husserl’s phenomenology and with Dilthey’s cultural science. Allgemeine Psychopathologie and other methodological works by Jaspers, the works of Husserl and Dilthey that Jaspers cited, and previous research papers on Jaspers are reviewed. Jaspers had conflicting views on understanding, which were comprised of both empathic understanding and rational, ideal-typical understanding. Such a standpoint on understanding is considerably different from Dilthey’s. Additionally, the present paper reconfirms that Jaspers’ ‘phenomenology’ as a form of descriptive psychology for the understanding of empirical psychic states is different from Husserl’s phenomenology. Thus, this paper casts doubt on the common opinion that Jaspers was under the profound influence of Husserl or Dilthey. PMID:24573260
Calculating and Understanding: Formal Models and Causal Explanations in Science, Common Reasoning and Physics Teaching

NASA Astrophysics Data System (ADS)

Besson, Ugo

2010-03-01

This paper presents an analysis of the different types of reasoning and physical explanation used in science, common thought, and physics teaching. It then reflects on the learning difficulties connected with these various approaches, and suggests some possible didactic strategies. Although causal reasoning occurs very frequently in common thought and daily life, it has long been the subject of debate and criticism among philosophers and scientists. In this paper, I begin by providing a description of some general tendencies of common reasoning that have been identified by didactic research. Thereafter, I briefly discuss the role of causality in science, as well as some different types of explanation employed in the field of physics. I then present some results of a study examining the causal reasoning used by students in solid and fluid mechanics. The differences found between the types of reasoning typical of common thought and those usually proposed during instruction can create learning difficulties and impede student motivation. Many students do not seem satisfied by the mere application of formal laws and functional relations. Instead, they express the need for a causal explanation, a mechanism that allows them to understand how a state of affairs has come about. I discuss few didactic strategies aimed at overcoming these problems, and describe, in general terms, two examples of mechanics teaching sequences which were developed and tested in different contexts. The paper ends with a reflection on the possible role to be played in physics learning by intuitive and imaginative thought, and the use of simple explanatory models based on physical analogies and causal mechanisms.
Seasonal food habits of the coyote in the South Carolina coastal plain.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schrecengost, J. D.; Kilgo, J. C.; Mallard, D.

2008-07-01

Abstract - Spatial and temporal plasticity in Canis latrans (coyote) diets require regional studies to understand the ecological role of this omnivorous canid. Because coyotes have recently become established in South Carolina, we investigated their food habits by collecting 415 coyote scats on the Savannah River Site in western South Carolina from May 2005-July 2006. Seasonally available soft mast was the most common food item in 12 of the 15 months we sampled. Odocoileus virginianus (white-tailed deer) was the most common food item during December (40%) and March (37%). During May-June, fruits of Prunus spp. and Rubus spp. were themore » most commonly occurring food items. Fawns were the most common mammalian food item during May and June of both years despite low deer density.« less
Centers for Oceans and Human Health: a unified approach to the challenge of harmful algal blooms

PubMed Central

Erdner, Deana L; Dyble, Julianne; Parsons, Michael L; Stevens, Richard C; Hubbard, Katherine A; Wrabel, Michele L; Moore, Stephanie K; Lefebvre, Kathi A; Anderson, Donald M; Bienfang, Paul; Bidigare, Robert R; Parker, Micaela S; Moeller, Peter; Brand, Larry E; Trainer, Vera L

2008-01-01

Background Harmful algal blooms (HABs) are one focus of the national research initiatives on Oceans and Human Health (OHH) at NIEHS, NOAA and NSF. All of the OHH Centers, from the east coast to Hawaii, include one or more research projects devoted to studying HAB problems and their relationship to human health. The research shares common goals for understanding, monitoring and predicting HAB events to protect and improve human health: understanding the basic biology of the organisms; identifying how chemistry, hydrography and genetic diversity influence blooms; developing analytical methods and sensors for cells and toxins; understanding health effects of toxin exposure; and developing conceptual, empirical and numerical models of bloom dynamics. Results In the past several years, there has been significant progress toward all of the common goals. Several studies have elucidated the effects of environmental conditions and genetic heterogeneity on bloom dynamics. New methods have been developed or implemented for the detection of HAB cells and toxins, including genetic assays for Pseudo-nitzschia and Microcystis, and a biosensor for domoic acid. There have been advances in predictive models of blooms, most notably for the toxic dinoflagellates Alexandrium and Karenia. Other work is focused on the future, studying the ways in which climate change may affect HAB incidence, and assessing the threat from emerging HABs and toxins, such as the cyanobacterial neurotoxin β-N-methylamino-L-alanine. Conclusion Along the way, many challenges have been encountered that are common to the OHH Centers and also echo those of the wider HAB community. Long-term field data and basic biological information are needed to develop accurate models. Sensor development is hindered by the lack of simple and rapid assays for algal cells and especially toxins. It is also critical to adequately understand the human health effects of HAB toxins. Currently, we understand best the effects of acute toxicity, but almost nothing is known about the effects of chronic, subacute toxin exposure. The OHH initiatives have brought scientists together to work collectively on HAB issues, within and across regions. The successes that have been achieved highlight the value of collaboration and cooperation across disciplines, if we are to continue to advance our understanding of HABs and their relationship to human health. PMID:19025673
Making Scientific Data Usable and Useful

NASA Astrophysics Data System (ADS)

Satwicz, T.; Bharadwaj, A.; Evans, J.; Dirks, J.; Clark Cole, K.

2017-12-01

Transforming geological data into information that has broad scientific and societal impact is a process fraught with barriers. Data sets and tools are often reported to have poor user experiences (UX) that make scientific work more challenging than it needs be. While many other technical fields have benefited from ongoing improvements to the UX of their tools (e.g., healthcare and financial services) scientists are faced with using tools that are labor intensive and not intuitive. Our research team has been involved in a multi-year effort to understand and improve the UX of scientific tools and data sets. We use a User-Centered Design (UCD) process that involves naturalistic behavioral observation and other qualitative research methods adopted from Human-Computer Interaction (HCI) and related fields. Behavioral observation involves having users complete common tasks on data sets, tools, and websites to identify usability issues and understand the severity of the issues. We measure how successfully they complete tasks and diagnosis the cause of any failures. Behavioral observation is paired with in-depth interviews where users describe their process for generating results (from initial inquiry to final results). By asking detailed questions we unpack common patterns and challenges scientists experience while working with data. We've found that tools built using the UCD process can have a large impact on scientist work flows and greatly reduce the time it takes to process data before analysis. It is often challenging to understand the organization and nuances of data across scientific fields. By better understanding how scientists work we can create tools that make routine tasks less-labor intensive, data easier to find, and solve common issues with discovering new data sets and engaging in interdisciplinary research. There is a tremendous opportunity for advancing scientific knowledge and helping the public benefit from that work by creating intuitive, interactive, and powerful tools and resources for generating knowledge. The pathway to achieving that is through building a detailed understanding of users and their needs, then using this knowledge to inform the design of the data products, tools, and services scientists and non-scientists use to do their work.
Rewriting the future? Biomedical advances and legal dilemmas.

PubMed

Bennett, Belinda

2006-02-01

Developments in medical science have sparked public debate about the legal and ethical implications of new technologies. Within these debates a number of distinct discourses are evident, including discourses about the positive and negative implications of technological advances, the influence of globalisation on regulatory choice, and the challenges of articulating common values in a pluralistic society. This article argues that an understanding of these discourses is an essential part of understanding the nature of contemporary regulatory dilemmas.
Observing and understanding the ultrafast photochemistry in small molecules: applications to sunscreens.

PubMed

Baker, Lewis A; Stavros, Vasilios G

2016-09-01

In this review, we discuss the importance of biological and artificial photoprotection against overexposure to harmful ultraviolet radiation. Transient electronic and transient vibrational absorption spectroscopies are highlighted as important tools in understanding the energy transfer in small molecules, with a focus on the application to commercial sunscreens with representative examples given. Oxybenzone, a common ingredient in commercial sunscreens and sinapoyl malate, a biological sunscreen in plant leaves are presented as case studies.
New paradigms in understanding chronic pelvic pain syndrome.

PubMed

Konkle, Katy S; Clemens, J Quentin

2011-08-01

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common male pain condition that is associated with significant discomfort and disability. Despite significant efforts, there remains no definitive etiology or treatment of the spectrum of pelvic symptoms reported by these patients. The purpose of this review is to summarize important clinical and scientific findings related to CP/CPPS from the previous 2 years, and to evaluate their impact on our understanding of, and approach to, the disease.
Immune-mediated hemolytic anemia: understanding the nemesis.

PubMed

McCullough, Sheila

2003-11-01

IMHA is one of the most common causes of anemia in small animals. Although treatment may be rewarding, many patients do not respond adequately to glucocorticoids alone and require additional immunosuppressive therapy. Some patients may succumb to acute severe anemia and die within the first few weeks of treatment; even if they survive, relapses may occur. IMHA is the nemesis; as our understanding of this disease increases and treatment options expand, it is hoped that survival rates will finally improve.

Skeletal effects of carcinoma of the breast and prostate.

PubMed Central

Percival, R. C.

1986-01-01

Recent research has led to improved understanding of the pathology of skeletal metastases in carcinoma of the breast and prostate. Several humoral mechanisms have been identified which have both primary and secondary consequences on skeletal metabolism and probably depend on the complex interplay of a number of factors derived from tumour tissues. An improved understanding of these interactions may lead to new approaches in the management of these common disorders. Images Fig. 1 PMID:3789624
Working Toward An Informed Society

NASA Astrophysics Data System (ADS)

Hill, R. L.

2006-12-01

Despite major differences in the nature of their jobs, scientists and journalists are alike in many ways: a curiosity about the world, a healthy skepticism, a continuing reexamination of their work and professions. Reporters and researchers need to understand better how their disparate worlds function in order to close the gap between science and journalism. They both need to actively participate in a common goal of communicating science and making complex scientific topics understandable and interesting to the public.
Improvements In AF Ablation Outcome Will Be Based More On Technological Advancement Versus Mechanistic Understanding.

PubMed

Jiang Md, Chen-Yang; Jiang Ms, Ru-Hong

2014-01-01

Atrial fibrillation (AF) is one of the most common cardiac arrhythmias. Catheter ablation has proven more effective than antiarrhythmic drugs in preventing clinical recurrence of AF, however long-term outcome remains unsatisfactory. Ablation strategies have evolved based on progress in mechanistic understanding, and technologies have advanced continuously. This article reviews current mechanistic concepts and technological advancements in AF treatment, and summarizes their impact on improvement of AF ablation outcome.
The EvoDevoCI: A Concept Inventory for Gauging Students’ Understanding of Evolutionary Developmental Biology

PubMed Central

Perez, Kathryn E.; Hiatt, Anna; Davis, Gregory K.; Trujillo, Caleb; French, Donald P.; Terry, Mark; Price, Rebecca M.

2013-01-01

The American Association for the Advancement of Science 2011 report Vision and Change in Undergraduate Biology Education encourages the teaching of developmental biology as an important part of teaching evolution. Recently, however, we found that biology majors often lack the developmental knowledge needed to understand evolutionary developmental biology, or “evo-devo.” To assist in efforts to improve evo-devo instruction among undergraduate biology majors, we designed a concept inventory (CI) for evolutionary developmental biology, the EvoDevoCI. The CI measures student understanding of six core evo-devo concepts using four scenarios and 11 multiple-choice items, all inspired by authentic scientific examples. Distracters were designed to represent the common conceptual difficulties students have with each evo-devo concept. The tool was validated by experts and administered at four institutions to 1191 students during preliminary (n = 652) and final (n = 539) field trials. We used student responses to evaluate the readability, difficulty, discriminability, validity, and reliability of the EvoDevoCI, which included items ranging in difficulty from 0.22–0.55 and in discriminability from 0.19–0.38. Such measures suggest the EvoDevoCI is an effective tool for assessing student understanding of evo-devo concepts and the prevalence of associated common conceptual difficulties among both novice and advanced undergraduate biology majors. PMID:24297293
Bottom's Semiology: The Duck-Rabbit and Magritte's Pipe.

ERIC Educational Resources Information Center

Berthoff, Ann E.

1993-01-01

Explores how a dyadic understanding of perception cancels the validity it might have as a model for the linguistic process. Discusses commonly misunderstood exhibits in the gallery of perception studies--the duck-rabbit and Magritte's pipe. (RS)
Distracted driving and associated crash risks.

DOT National Transportation Integrated Search

2014-10-01

Distracted driving is a dangerous epidemic that has resulted in deaths and injuries in crashes throughout the U.S. Research is : needed to understand whether common cognitive tasks such as texting, handheld cell phone conversation, and front-seat : p...
Understanding Resource Allocation in High Schools.

ERIC Educational Resources Information Center

Hartman, William T.

Despite commonly held views concerning educators' rational decision-making behavior, there are competing interpretations of school personnels' objective, actions, and decision-making processes. Alternative explanations emphasize bureaucratic routine, administrative convenience, educator self-interest, and political motivations, rather than…
The Greekless Reader and Aristotle's "Rhetoric."

ERIC Educational Resources Information Center

Conley, Thomas M.

1979-01-01

Discusses the inadequacy of translations of Aristotle's "Rhetoric," particularly three passages from the commonly used translation by Lane Cooper. The misleading nature of these passages is cited as a major cause for the lack of understanding of Aristotle. (JMF)
The RAS Problem: Turning Off a Broken Switch

Cancer.gov

The RAS gene is commonly mutated in cancer and researchers are working to better understand how to develop drugs that can target the RAS protein, which for many years has been considered to be “undruggable.”
Generalized anxiety disorder - self-care

MedlinePlus

... helpful for GAD. One common and effective talk therapy is cognitive-behavioral therapy (CBT). CBT can help you understand ... MW, Rosenfield E, Wilhelm S. Cognitive-behavioral therapy, behavioral therapy, and cognitive therapy. In: Stern TA, Fava M, Wilens TE, ...
Understanding a Normal Distribution of Data.

PubMed

Maltenfort, Mitchell G

2015-12-01

Assuming data follow a normal distribution is essential for many common statistical tests. However, what are normal data and when can we assume that a data set follows this distribution? What can be done to analyze non-normal data?
Medical marijuana use for chronic pain: risks and benefits.

PubMed

Greenwell, Garth T

2012-01-01

Questions from patients about medical marijuana use for chronic pain are becoming more common. The information in this report will help patients understand the potential risks and benefits of using this substance for painful conditions.
Understanding and Developing Controversial Issues in College Courses.

ERIC Educational Resources Information Center

Payne, Brian K.; Gainey, Randy R.

2003-01-01

Discusses common controversial issues in different college disciplines, such as the death penalty and drug legalization. Also suggests useful methods for encouraging enlightening discussions, such as verbal and physical cues, student-centered activities, and text selection. (SLD)
Understanding Pennsylvania living wills: the 5 Ws.

PubMed

Pina, Linda L

2009-12-01

The working world of nurses is often filled with deep-running emotions and physical exhaustion as we care for our dying patients. We feel the need to step back and gain perspective when faced with a dying patient, or more appropriately, a dying person. We must also keep in mind the family of the dying who may have similar feelings. It is nearly impossible to be a nurse and not have to care for a dying patient; thus, we often find ourselves dealing with living wills. The living will is the more common of the two forms of an advance directive; the other is the durable power of attorney for healthcare. Since living wills are so common, and laws about them vary from state-to-state, it is important for the professional nurse in Pennsylvania to understand how living wills work in our state. This may best be approached by considering the 5 Ws related to living wills.
Molecular simulations of heterogeneous ice nucleation. I. Controlling ice nucleation through surface hydrophilicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cox, Stephen J.; Kathmann, Shawn M.; Slater, B.

2015-05-14

Ice formation is one of the most common and important processes on earth and almost always occurs at the surface of a material. A basic understanding of how the physicochemical properties of a material’s surface affect its ability to form ice has remained elusive. Here, we use molecular dynamics simulations to directly probe heterogeneous ice nucleation at a hexagonal surface of a nanoparticle of varying hydrophilicity. Surprisingly, we find that structurally identical surfaces can both inhibit and promote ice formation and analogous to a chemical catalyst, it is found that an optimal interaction between the surface and the water existsmore » for promoting ice nucleation.We use our microscopic understanding of the mechanism to design a modified surface in silico with enhanced ice nucleating ability. C 2015 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.« less
First order error corrections in common introductory physics experiments

NASA Astrophysics Data System (ADS)

Beckey, Jacob; Baker, Andrew; Aravind, Vasudeva; Clarion Team

As a part of introductory physics courses, students perform different standard lab experiments. Almost all of these experiments are prone to errors owing to factors like friction, misalignment of equipment, air drag, etc. Usually these types of errors are ignored by students and not much thought is paid to the source of these errors. However, paying attention to these factors that give rise to errors help students make better physics models and understand physical phenomena behind experiments in more detail. In this work, we explore common causes of errors in introductory physics experiment and suggest changes that will mitigate the errors, or suggest models that take the sources of these errors into consideration. This work helps students build better and refined physical models and understand physics concepts in greater detail. We thank Clarion University undergraduate student grant for financial support involving this project.
Animal Abuse and Interpersonal Violence: The Cruelty Connection and Its Implications for Veterinary Pathology.

PubMed

Lockwood, R; Arkow, P

2016-09-01

The role of the veterinary forensic pathologist in the investigation of animal abuse or neglect can go beyond documenting the condition of animals presented as evidence. Although animal cruelty is a moral concern and a crime in itself, law enforcement response to such crimes is often enhanced by the recognition that crimes against animals can be both indicators of other ongoing crimes against people and predictors of the potential for interpersonal violence. An understanding of common motives underlying animal cruelty can aid the pathologist in asking appropriate questions. The authors review the forms of pathology evidence commonly seen in various presentations of animal cruelty. Understanding these forms of evidence can help the pathologist describe findings that can be significant for assessing the potential risks the alleged perpetrator may pose to other animals and humans. © The Author(s) 2016.
Quantum-coherent mixtures of causal relations

NASA Astrophysics Data System (ADS)

Maclean, Jean-Philippe W.; Ried, Katja; Spekkens, Robert W.; Resch, Kevin J.

2017-05-01

Understanding the causal influences that hold among parts of a system is critical both to explaining that system's natural behaviour and to controlling it through targeted interventions. In a quantum world, understanding causal relations is equally important, but the set of possibilities is far richer. The two basic ways in which a pair of time-ordered quantum systems may be causally related are by a cause-effect mechanism or by a common-cause acting on both. Here we show a coherent mixture of these two possibilities. We realize this nonclassical causal relation in a quantum optics experiment and derive a set of criteria for witnessing the coherence based on a quantum version of Berkson's effect, whereby two independent causes can become correlated on observation of their common effect. The interplay of causality and quantum theory lies at the heart of challenging foundational puzzles, including Bell's theorem and the search for quantum gravity.
About being pure and natural: understandings of pre-service primary teachers

NASA Astrophysics Data System (ADS)

Lake, David

2005-04-01

In an investigation of 149 pre-service primary teachers' understanding of the terms pure and natural, the participants were asked to provide definitions of the two words, and classify various substances including drugs of abuse, pharmaceuticals, nutriceuticals, and household substances as either natural or not natural, and as pure or not pure. A common scale of purity and naturalness could be constructed consistent with the Rasch model, suggesting that the participants conflate the two terms. This conflation is consistent with the qualitative data that suggested participants associated both concepts within a common spiritual metaphor, heavily laden with emotive content. Purity was not seen as relating to the composition of a substance, but to its history. The findings may help explain the development of persistent non-scientific chemical taxonomies observed in secondary students. Furthermore, as health educators, the participants may become the source of inappropriate messages about the use of medicines, or the abuse of drugs.
A Qualitative Study on Incentives and Disincentives for Care of Common Mental Disorders in Ontario Family Health Teams

PubMed Central

Silveira, Jose; Mckenzie, Kwame

2016-01-01

Background: An opportunity to address the needs of patients with common mental disorders (CMDs) resides in primary care. Barriers are restricting availability of treatment for CMDs in primary care. By understanding the incentives that promote and the disincentives that deter treatment for CMDs in a collaborative primary care context, this study aims to help contribute to goals of greater access to mental healthcare. Method: A qualitative pilot study using semi-structured interviews with thematic analysis. Results: Participants identified 10 themes of incentives and disincentives influencing quality treatment of CMDs in a collaborative primary care setting: high service demands, clinical presentation, patient-centred care, patient attributes, education, physician attributes, organizational, access to mental health resources, psychiatry and physician payment model. Conclusion: An understanding of the incentives and disincentives influencing care is essential to achieve greater integration and capacity for care for the treatment of CMDs in primary care. PMID:27585029

Quantum-coherent mixtures of causal relations

PubMed Central

MacLean, Jean-Philippe W.; Ried, Katja; Spekkens, Robert W.; Resch, Kevin J.

2017-01-01

Understanding the causal influences that hold among parts of a system is critical both to explaining that system's natural behaviour and to controlling it through targeted interventions. In a quantum world, understanding causal relations is equally important, but the set of possibilities is far richer. The two basic ways in which a pair of time-ordered quantum systems may be causally related are by a cause-effect mechanism or by a common-cause acting on both. Here we show a coherent mixture of these two possibilities. We realize this nonclassical causal relation in a quantum optics experiment and derive a set of criteria for witnessing the coherence based on a quantum version of Berkson's effect, whereby two independent causes can become correlated on observation of their common effect. The interplay of causality and quantum theory lies at the heart of challenging foundational puzzles, including Bell's theorem and the search for quantum gravity. PMID:28485394
The Use of Animal Models for Stroke Research: A Review

PubMed Central

Casals, Juliana B; Pieri, Naira CG; Feitosa, Matheus LT; Ercolin, Anna CM; Roballo, Kelly CS; Barreto, Rodrigo SN; Bressan, Fabiana F; Martins, Daniele S; Miglino, Maria A; Ambrósio, Carlos E

2011-01-01

Stroke has been identified as the second leading cause of death worldwide. Stroke is a focal neurologic deficit caused by a change in cerebral circulation. The use of animal models in recent years has improved our understanding of the physiopathology of this disease. Rats and mice are the most commonly used stroke models, but the demand for larger models, such as rabbits and even nonhuman primates, is increasing so as to better understand the disease and its treatment. Although the basic mechanisms of stroke are nearly identical among mammals, we here discuss the differences between the human encephalon and various animals. In addition, we compare common surgical techniques used to induce animal models of stroke. A more complete anatomic knowledge of the cerebral vessels of various model species is needed to develop more reliable models for objective results that improve knowledge of the pathology of stroke in both human and veterinary medicine. PMID:22330245
Quantum-coherent mixtures of causal relations.

PubMed

MacLean, Jean-Philippe W; Ried, Katja; Spekkens, Robert W; Resch, Kevin J

2017-05-09

Understanding the causal influences that hold among parts of a system is critical both to explaining that system's natural behaviour and to controlling it through targeted interventions. In a quantum world, understanding causal relations is equally important, but the set of possibilities is far richer. The two basic ways in which a pair of time-ordered quantum systems may be causally related are by a cause-effect mechanism or by a common-cause acting on both. Here we show a coherent mixture of these two possibilities. We realize this nonclassical causal relation in a quantum optics experiment and derive a set of criteria for witnessing the coherence based on a quantum version of Berkson's effect, whereby two independent causes can become correlated on observation of their common effect. The interplay of causality and quantum theory lies at the heart of challenging foundational puzzles, including Bell's theorem and the search for quantum gravity.
Genetics of impulsive behaviour

PubMed Central

Bevilacqua, Laura; Goldman, David

2013-01-01

Impulsivity, defined as the tendency to act without foresight, comprises a multitude of constructs and is associated with a variety of psychiatric disorders. Dissecting different aspects of impulsive behaviour and relating these to specific neurobiological circuits would improve our understanding of the etiology of complex behaviours for which impulsivity is key, and advance genetic studies in this behavioural domain. In this review, we will discuss the heritability of some impulsivity constructs and their possible use as endophenotypes (heritable, disease-associated intermediate phenotypes). Several functional genetic variants associated with impulsive behaviour have been identified by the candidate gene approach and re-sequencing, and whole genome strategies can be implemented for discovery of novel rare and common alleles influencing impulsivity. Via deep sequencing an uncommon HTR2B stop codon, common in one population, was discovered, with implications for understanding impulsive behaviour in both humans and rodents and for future gene discovery. PMID:23440466
Atopic Dermatitis in Animals and People: An Update and Comparative Review

PubMed Central

Marsella, Rosanna; De Benedetto, Anna

2017-01-01

Atopic dermatitis is an extremely common, pruritic, and frustrating disease to treat in both people and animals. Atopic dermatitis is multifactorial and results from complex interactions between genetic and environmental factors. Much progress has been done in recent years in terms of understanding the complex pathogenesis of this clinical syndrome and the identification of new treatments. As we learn more about it, we appreciate the striking similarities that exist in the clinical manifestations of this disease across species. Both in animals and people, atopic disease is becoming increasingly common and important similarities exist in terms of immunologic aberrations and the propensity for allergic sensitization. The purpose of this review is to highlight the most recent views on atopic dermatitis in both domestic species and in people emphasizing the similarities and the differences. A comparative approach can be beneficial in understanding the natural course of this disease and the variable response to existing therapies. PMID:29056696
Atopic Dermatitis in Animals and People: An Update and Comparative Review.

PubMed

Marsella, Rosanna; De Benedetto, Anna

2017-07-26

Atopic dermatitis is an extremely common, pruritic, and frustrating disease to treat in both people and animals. Atopic dermatitis is multifactorial and results from complex interactions between genetic and environmental factors. Much progress has been done in recent years in terms of understanding the complex pathogenesis of this clinical syndrome and the identification of new treatments. As we learn more about it, we appreciate the striking similarities that exist in the clinical manifestations of this disease across species. Both in animals and people, atopic disease is becoming increasingly common and important similarities exist in terms of immunologic aberrations and the propensity for allergic sensitization. The purpose of this review is to highlight the most recent views on atopic dermatitis in both domestic species and in people emphasizing the similarities and the differences. A comparative approach can be beneficial in understanding the natural course of this disease and the variable response to existing therapies.
The caBIG® Life Science Business Architecture Model.

PubMed

Boyd, Lauren Becnel; Hunicke-Smith, Scott P; Stafford, Grace A; Freund, Elaine T; Ehlman, Michele; Chandran, Uma; Dennis, Robert; Fernandez, Anna T; Goldstein, Stephen; Steffen, David; Tycko, Benjamin; Klemm, Juli D

2011-05-15

Business Architecture Models (BAMs) describe what a business does, who performs the activities, where and when activities are performed, how activities are accomplished and which data are present. The purpose of a BAM is to provide a common resource for understanding business functions and requirements and to guide software development. The cancer Biomedical Informatics Grid (caBIG®) Life Science BAM (LS BAM) provides a shared understanding of the vocabulary, goals and processes that are common in the business of LS research. LS BAM 1.1 includes 90 goals and 61 people and groups within Use Case and Activity Unified Modeling Language (UML) Diagrams. Here we report on the model's current release, LS BAM 1.1, its utility and usage, and plans for future use and continuing development for future releases. The LS BAM is freely available as UML, PDF and HTML (https://wiki.nci.nih.gov/x/OFNyAQ).
A Life Below the Threshold?: Examining Conflict Between Ethical Principles and Parental Values in Neonatal Treatment Decision Making.

PubMed

Cunningham, Thomas V

2016-01-01

Three common ethical principles for establishing the limits of parental authority in pediatric treatment decision-making are the harm principle, the principle of best interest, and the threshold view. This paper considers how these principles apply to a case of a premature neonate with multiple significant co-morbidities whose mother wanted all possible treatments, and whose health care providers wondered whether it would be ethically permissible to allow him to die comfortably despite her wishes. Whether and how these principles help in understanding what was morally right for the child is questioned. The paper concludes that the principles were of some value in understanding the moral geography of the case; however, this case reveals that common bioethical principles for medical decision-making are problematically value-laden because they are inconsistent with the widespread moral value of medical vitalism.
When mechanism matters: Bayesian forecasting using models of ecological diffusion

USGS Publications Warehouse

Hefley, Trevor J.; Hooten, Mevin B.; Russell, Robin E.; Walsh, Daniel P.; Powell, James A.

2017-01-01

Ecological diffusion is a theory that can be used to understand and forecast spatio-temporal processes such as dispersal, invasion, and the spread of disease. Hierarchical Bayesian modelling provides a framework to make statistical inference and probabilistic forecasts, using mechanistic ecological models. To illustrate, we show how hierarchical Bayesian models of ecological diffusion can be implemented for large data sets that are distributed densely across space and time. The hierarchical Bayesian approach is used to understand and forecast the growth and geographic spread in the prevalence of chronic wasting disease in white-tailed deer (Odocoileus virginianus). We compare statistical inference and forecasts from our hierarchical Bayesian model to phenomenological regression-based methods that are commonly used to analyse spatial occurrence data. The mechanistic statistical model based on ecological diffusion led to important ecological insights, obviated a commonly ignored type of collinearity, and was the most accurate method for forecasting.
The epidemiology of supernumerary teeth and the associated molecular mechanism

PubMed Central

Lu, Xi; Yu, Fang; Liu, Junjun; Cai, Wenping; Zhao, Yumei; Zhao, Shouliang; Liu, Shangfeng

2017-01-01

ABSTRACT Supernumerary teeth are common clinical dental anomalies. Although various studies have provided abundant information regarding genes and signaling pathways involved in tooth morphogenesis, which include Wnt, FGF, BMP, and Shh, the molecular mechanism of tooth formation, especially for supernumerary teeth, is still unclear. In the population, some cases of supernumerary teeth are sporadic, while others are syndrome-related with familial hereditary. The prompt and accurate diagnosis of syndrome related supernumerary teeth is quite important for some distinctive disorders. Mice are the most commonly used model system for investigating supernumerary teeth. The upregulation of Wnt and Shh signaling in the dental epithelium results in the formation of multiple supernumerary teeth in mice. Understanding the molecular mechanism of supernumerary teeth is also a component of understanding tooth formation in general and provides clinical guidance for early diagnosis and treatment in the future. PMID:28598258
The Genetics of Asthma and Allergic Disease: A 21st Century Perspective

PubMed Central

Ober, Carole; Yao, Tsung-Chieh

2011-01-01

Summary Asthma and allergy are common conditions with complex etiologies involving both genetic and environmental contributions. Recent genome-wide association studies (GWAS) and meta-analyses of GWAS have begun to shed light on both common and distinct pathways that contribute to asthma and allergic diseases. Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 (Th2) cells in the pathogenesis of both asthma and allergic diseases. In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma. These and other genetic findings are providing a list of well-validated asthma and allergy susceptibility genes that are expanding our understanding of the common and unique biological pathways that are dysregulated in these related conditions. Ongoing studies will continue to broaden our understanding of asthma and allergy and unravel the mechanisms for the development of these complex traits. PMID:21682736
Mitochondrial Disorders of DNA Polymerase γ Dysfunction

PubMed Central

Zhang, Linsheng; Chan, Sherine S. L.; Wolff, Daynna J.

2011-01-01

Context Primary mitochondrial dysfunction is one of the most common causes of inherited disorders predominantly involving the neuromuscular system. Advances in the molecular study of mitochondrial DNA have changed our vision and our approach to primary mitochondrial disorders. Many of the mitochondrial disorders are caused by mutations in nuclear genes and are inherited in an autosomal recessive pattern. Among the autosomal inherited mitochondrial disorders, those related to DNA polymerase γ dysfunction are the most common and the best studied. Understanding the molecular mechanisms and being familiar with the recent advances in laboratory diagnosis of this group of mitochondrial disorders are essential for pathologists to interpret abnormal histopathology and laboratory results and to suggest further studies for a definitive diagnosis. Objectives To help pathologists better understand the common clinical syndromes originating from mutations in DNA polymerase γ and its associated proteins and use the stepwise approach of clinical, laboratory, and pathologic diagnosis of these syndromes. Data Sources Review of pertinent published literature and relevant Internet databases. Conclusions Mitochondrial disorders are now better recognized with the development of molecular tests for clinical diagnosis. A cooperative effort among primary physicians, diagnostic pathologists, geneticists, and molecular biologists with expertise in mitochondrial disorders is required to reach a definitive diagnosis. PMID:21732785
Methodology Series Module 10: Qualitative Health Research

PubMed Central

Setia, Maninder Singh

2017-01-01

Although quantitative designs are commonly used in clinical research, some studies require qualitative methods. These designs are different from quantitative methods; thus, researchers should be aware of data collection methods and analyses for qualitative research. Qualitative methods are particularly useful to understand patient experiences with the treatment or new methods of management or to explore issues in detail. These methods are useful in social and behavioral research. In qualitative research, often, the main focus is to understand the issue in detail rather than generalizability; thus, the sampling methods commonly used are purposive sampling; quota sampling; and snowball sampling (for hard to reach groups). Data can be collected using in-depth interviews (IDIs) or focus group discussions (FGDs). IDI is a one-to-one interview with the participant. FGD is a method of group interview or discussion, in which more than one participant is interviewed at the same time and is usually led by a facilitator. The commonly used methods for data analysis are: thematic analysis; grounded theory analysis; and framework analysis. Qualitative data collection and analysis require special expertise. Hence, if the reader plans to conduct qualitative research, they should team up with a qualitative researcher. PMID:28794545
Methodology Series Module 10: Qualitative Health Research.

PubMed

Setia, Maninder Singh

2017-01-01

Although quantitative designs are commonly used in clinical research, some studies require qualitative methods. These designs are different from quantitative methods; thus, researchers should be aware of data collection methods and analyses for qualitative research. Qualitative methods are particularly useful to understand patient experiences with the treatment or new methods of management or to explore issues in detail. These methods are useful in social and behavioral research. In qualitative research, often, the main focus is to understand the issue in detail rather than generalizability; thus, the sampling methods commonly used are purposive sampling; quota sampling; and snowball sampling (for hard to reach groups). Data can be collected using in-depth interviews (IDIs) or focus group discussions (FGDs). IDI is a one-to-one interview with the participant. FGD is a method of group interview or discussion, in which more than one participant is interviewed at the same time and is usually led by a facilitator. The commonly used methods for data analysis are: thematic analysis; grounded theory analysis; and framework analysis. Qualitative data collection and analysis require special expertise. Hence, if the reader plans to conduct qualitative research, they should team up with a qualitative researcher.
Genetics of nonsyndromic obesity.

PubMed

Lee, Yung Seng

2013-12-01

Common obesity is widely regarded as a complex, multifactorial trait influenced by the 'obesogenic' environment, sedentary behavior, and genetic susceptibility contributed by common and rare genetic variants. This review describes the recent advances in understanding the role of genetics in obesity. New susceptibility loci and genetic variants are being uncovered, but the collective effect is relatively small and could not explain most of the BMI heritability. Yet-to-be identified common and rare variants, epistasis, and heritable epigenetic changes may account for part of the 'missing heritability'. Evidence is emerging about the role of epigenetics in determining obesity susceptibility, mediating developmental plasticity, which confers obesity risk from early life experiences. Genetic prediction scores derived from selected genetic variants, and also differential DNA methylation levels and methylation scores, have been shown to correlate with measures of obesity and response to weight loss intervention. Genetic variants, which confer susceptibility to obesity-related morbidities like nonalcoholic fatty liver disease, were also discovered recently. We can expect discovery of more rare genetic variants with the advent of whole exome and genome sequencing, and also greater understanding of epigenetic mechanisms by which environment influences genetic expression and which mediate the gene-environment interaction.
2016 International Orthoptic Congress Burian Lecture: Folklore or Evidence?

PubMed

Horwood, Anna M

2017-09-01

The theme of the 2016 Burian Lecture is how our understanding of strabismus has been changed by the research carried out in our laboratory in Reading over the years. Accommodation and convergence are fundamental to orthoptics, but actual responses have often been very different compared to what we had expected. This paper outlines how our laboratory's understanding of common issues such as normal development of accommodation and convergence, their linkage, intermittent strabismus, anisometropia, orthoptic exercises, and risk factors for strabismus have changed. A new model of thinking about convergence and accommodation may help us to better understand and predict responses in our patients.
2016 International Orthoptic Congress Burian Lecture: Folklore or Evidence?

PubMed Central

Horwood, Anna M

2017-01-01

The theme of the 2016 Burian Lecture is how our understanding of strabismus has been changed by the research carried out in our laboratory in Reading over the years. Accommodation and convergence are fundamental to Orthoptics, but actual responses have often been very different to what we had expected. This paper outlines how our laboratory’s understanding of common issues such as normal development of accommodation and convergence, their linkage, intermittent strabismus, anisometropia, orthoptic exercises and risk factors for strabismus have changed. A new model of thinking about convergence and accommodation may help us to better understand and predict responses in our patients. PMID:28426269
Overview of exocrine pancreatic pathobiology.

PubMed

Pandiri, Arun R

2014-01-01

Exocrine pancreas is a source of several enzymes that are essential for the digestive process. The exocrine pancreatic secretion is tightly regulated by the neuroendocrine system. The endocrine pancreas is tightly integrated anatomically and physiologically with the exocrine pancreas and modulates its function. Compound-induced pancreatitis is not a common event in toxicology or drug development, but it becomes a significant liability when encountered. Understanding the species-specific differences in physiology is essential to understand the underlying pathobiology of pancreatic disease in animal models and its relevance to human disease. This review will mainly focus on understanding the morphology and physiology of the pancreas, unique islet-exocrine interactions, and pancreatitis.
Cellular metabolism and disease: what do metabolic outliers teach us?

PubMed Central

DeBerardinis, Ralph J.; Thompson, Craig B.

2012-01-01

An understanding of metabolic pathways based solely on biochemistry textbooks would underestimate the pervasive role of metabolism in essentially every aspect of biology. It is evident from recent work that many human diseases involve abnormal metabolic states – often genetically programmed – that perturb normal physiology and lead to severe tissue dysfunction. Understanding these metabolic outliers is now a crucial frontier in disease-oriented research. This review discusses the broad impact of metabolism in cellular function, how modern concepts of metabolism can inform our understanding of common diseases like cancer, and considers the prospects of developing new metabolic approaches to disease treatment. PMID:22424225
A framework for understanding and advancing intertemporal choice research using rodent models

PubMed Central

Fobbs, Wambura C.; Mizumori, Sheri J. Y.

2017-01-01

Intertemporal choices are common and consequential to private and public life. Thus, there is considerable interest in understanding the neural basis of intertemporal decision making. In this minireview, we briefly describe conceptual and psychological perspectives on intertemporal choice and then provide a comprehensive evaluation of the neural structures and signals that comprise the underlying cortico-limbic-striatal circuit. Even though great advances have been made, our understanding of the neurobiology of intertemporal choice is still in its infancy because of the complex and dynamic nature of this form of decision making. We close by briefly discussing recommendations for the future study of intertemporal choice research. PMID:28065715

Reconstructing Student Conceptions of Climate Change; An Inquiry Approach

NASA Astrophysics Data System (ADS)

McClelland, J. Collin

No other environmental issue today has as much potential to alter life on Earth as does global climate change. Scientific evidence continues to grow; indicating that climate change is occurring now, and that change is a result of human activities (National Research Council [NRC], 2010). The need for climate literacy in society has become increasingly urgent. Unfortunately, understanding the concepts necessary for climate literacy remains a challenge for most individuals. A growing research base has identified a number of common misconceptions people have about climate literacy concepts (Leiserowitz, Smith, & Marlon 2011; Shepardson, Niyogi, Choi, & Charusombat, 2009). However, few have explored this understanding in high school students. This sequential mixed methods study explored the changing conceptions of global climate change in 90 sophomore biology students through the course of their participation in an eight-week inquiry-based global climate change unit. The study also explored changes in students' attitudes over the course of the study unit, contemplating possible relationships between students' conceptual understanding of and attitudes toward global climate change. Phase I of the mixed methods study included quantitative analysis of pre-post content knowledge and attitude assessment data. Content knowledge gains were statistically significant and over 25% of students in the study shifted from an expressed belief of denial or uncertainty about global warming to one of belief in it. Phase II used an inductive approach to explore student attitudes and conceptions. Conceptually, very few students grew to a scientifically accurate understanding of the greenhouse effect or the relationship between global warming and climate change. However, they generally made progress in their conceptual understanding by adding more specific detail to explain their understanding. Phase III employed a case study approach with eight purposefully selected student cases, identifying five common conceptual and five common attitudebased themes. Findings suggest similar misconceptions revealed in prior research also occurred in this study group. Some examples include; connecting global warming to the hole in the ozone layer, and falsely linking unrelated environmental issues like littering to climate change. Data about students' conceptual understanding of energy may also have implications for education research curriculum development. Similar to Driver & While no statistical relationship between students' attitudes about global climate change and overall conceptual understanding emerged, some data suggested that climate change skeptics may perceive the concept of evidence differently than non-skeptics. One-way ANOVA data comparing skeptics with other students on evidence-based assessment items was significant. This study offers insights to teachers of potential barriers students face when trying to conceptualize global climate change concepts. More importantly it reinforces the idea that students generally find value in learning about global climate change in the classroom.
Communicating Genetic and Genomic Information: Health Literacy and Numeracy Considerations

PubMed Central

Lea, D.H.; Kaphingst, K.A.; Bowen, D.; Lipkus, I.; Hadley, D.W.

2011-01-01

Genomic research is transforming our understanding of the role of genes in health and disease. These advances, and their application to common diseases that affect large segments of the general population, suggest that researchers and practitioners in public health genomics will increasingly be called upon to translate genomic information to individuals with varying levels of health literacy and numeracy. This paper discusses the current state of research regarding public understanding of genetics and genomics, the influence of health literacy and numeracy on genetic communication, and behavioral responses to genetic and genomic information. The existing research suggests that members of the general public have some familiarity with genetic and genomic terms but have gaps in understanding of underlying concepts. Findings from the limited research base to date indicate that health literacy affects understanding of print and oral communications about genetic and genomic information. Numeracy is also likely to be an important predictor of being able to understand and apply this information, although little research has been conducted in this area to date. In addition, although some research has examined behavior change in response to the receipt of information about genetic risk for familial disorders and genomic susceptibility to common, complex diseases, the effects of health literacy and numeracy on these responses have not been examined. Potential areas in which additional research is needed are identified and practical suggestions for presenting numeric risk information are outlined. Public health genomics researchers and practitioners are uniquely positioned to engage in research that explores how different audiences react to and use genomic risk information. PMID:20407217
Features of resilience

DOE PAGES

Connelly, Elizabeth B.; Allen, Craig R.; Hatfield, Kirk; ...

2017-02-20

The National Academy of Sciences (NAS) definition of resilience is used here to organize common concepts and synthesize a set of key features of resilience that can be used across diverse application domains. The features in common include critical functions (services), thresholds, cross-scale (both space and time) interactions, and memory and adaptive management. We propose a framework for linking these features to the planning, absorbing, recovering, and adapting phases identified in the NAS definition. As a result, the proposed delineation of resilience can be important in understanding and communicating resilience concepts.
Features of resilience

USGS Publications Warehouse

Connelly, Elizabeth B.; Allen, Craig R.; Hatfield, Kirk; Palma-Oliveira, José M.; Woods, David D.; Linkov, Igor

2017-01-01

The National Academy of Sciences (NAS) definition of resilience is used here to organize common concepts and synthesize a set of key features of resilience that can be used across diverse application domains. The features in common include critical functions (services), thresholds, cross-scale (both space and time) interactions, and memory and adaptive management. We propose a framework for linking these features to the planning, absorbing, recovering, and adapting phases identified in the NAS definition. The proposed delineation of resilience can be important in understanding and communicating resilience concepts.
Business ethics and health care: a stakeholder perspective.

PubMed

Gilmartin, Mattia J; Freeman, R Edward

2002-01-01

This article examines the recent controversy in health care delivery about whether it should be conceptualized as a business. The current debate implicitly appeals to a common understanding of business and business practices that is no longer very useful. This common notion, which the authors call "cowboy capitalism," conceptualizes business as a competitive jungle resting on self-interest and an urge for competition in order to survive. The authors suggest that stakeholder capitalism offers a more useful framework for the dialogue about health care reform.
Hip Arthroscopy: Common Problems and Solutions.

PubMed

Casp, Aaron; Gwathmey, Frank Winston

2018-04-01

The use of hip arthroscopy continues to expand. Understanding potential pitfalls and complications associated with hip arthroscopy is paramount to optimizing clinical outcomes and minimizing unfavorable results. Potential pitfalls and complications are associated with preoperative factors such as patient selection, intraoperative factors such as iatrogenic damage, traction-related complications, inadequate correction of deformity, and nerve injury, or postoperative factors such as poor rehabilitation. This article outlines common factors that contribute to less-than-favorable outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.
Ultrasound-Guided Foot and Ankle Procedures.

PubMed

Henning, P Troy

2016-08-01

This article reviews commonly performed injections about the foot and ankle region. Although not exhaustive in its description of available techniques, general approaches to these procedures are applicable to any injection about the foot and ankle. As much as possible, the procedures described are based on commonly used or published techniques. An in-depth knowledge of the regional anatomy and understanding of different approaches when performing ultrasonography-guided procedures allows clinicians to adapt to any clinical scenario. Copyright © 2016 Elsevier Inc. All rights reserved.
The Search for Peace in Europe: Perspectives from NATO and Eastern Europe

DTIC Science & Technology

1993-01-01

U.S.S.R. and its satellites, cemented by the confrontation between the U.S. and the U.S.S.R. Since 1991, however, the political-territorial dimension of the...the same, it would be excessively optimistic to say that .the crumbling "old" Eurasian space has been cemented according to new rules as effectively and...Europe, and the German language, paradoxically, has been a common instrument for understanding among Slavic peoples. Fluency in German is common for
Vascular dementia: Pharmacological treatment approaches and perspectives

PubMed Central

Baskys, Andrius; Hou, Anthony C

2007-01-01

Vascular dementia is a common condition for which there are no effective approved pharmacological treatments available. Absence of effective treatments creates a difficult situation for those suffering from the disease, their caregivers, and healthcare providers. This review will address our current understanding of the mechanisms of nerve cell damage due to ischemia and summarize available clinical trial data on several commonly used compounds including memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDP-choline, folic acid, as well as such nonpharmacological approaches as validation therapy. PMID:18044183
Mathematics, thermodynamics, and modeling to address ten common misconceptions about protein structure, folding, and stability.

PubMed

Robic, Srebrenka

2010-01-01

To fully understand the roles proteins play in cellular processes, students need to grasp complex ideas about protein structure, folding, and stability. Our current understanding of these topics is based on mathematical models and experimental data. However, protein structure, folding, and stability are often introduced as descriptive, qualitative phenomena in undergraduate classes. In the process of learning about these topics, students often form incorrect ideas. For example, by learning about protein folding in the context of protein synthesis, students may come to an incorrect conclusion that once synthesized on the ribosome, a protein spends its entire cellular life time in its fully folded native confirmation. This is clearly not true; proteins are dynamic structures that undergo both local fluctuations and global unfolding events. To prevent and address such misconceptions, basic concepts of protein science can be introduced in the context of simple mathematical models and hands-on explorations of publicly available data sets. Ten common misconceptions about proteins are presented, along with suggestions for using equations, models, sequence, structure, and thermodynamic data to help students gain a deeper understanding of basic concepts relating to protein structure, folding, and stability.
Staff nurse clinical leadership: a concept analysis.

PubMed

Chávez, Eduardo C; Yoder, Linda H

2015-01-01

The purpose of this article is to provide a concept analysis of staff nurse clinical leadership (SNCL). A clear delineation of SNCL will promote understanding and encourage communication of the phenomenon. Clarification of the concept will establish a common understanding of the concept, and advance the practice, education, and research of this phenomenon. A review of the literature was conducted using several databases. The databases were searched using the following keywords: clinical leadership, nursing, bedside, staff nurse, front-line, front line, and leadership. The search yielded several sources; however, only those that focused on clinical leadership demonstrated by staff nurses in acute care hospital settings were selected for review. SNCL is defined as staff nurses who exert significant influence over other individuals in the healthcare team, and although no formal authority has been vested in them facilitates individual and collective efforts to accomplish shared clinical objectives. The theoretical definition for SNCL within the team context will provide a common understanding of this concept and differentiate it from other types of leadership in the nursing profession. This clarification and conceptualization of the concept will assist further research of the concept and advance its practical application in acute care hospital settings. © 2014 Wiley Periodicals, Inc.
The Virtual Learning Commons (VLC): Enabling Co-Innovation Across Disciplines

NASA Astrophysics Data System (ADS)

Pennington, D. D.; Gandara, A.; Del Rio, N.

2014-12-01

A key challenge for scientists addressing grand-challenge problems is identifying, understanding, and integrating potentially relevant methods, models and tools that that are rapidly evolving in the informatics community. Such tools are essential for effectively integrating data and models in complex research projects, yet it is often difficult to know what tools are available and it is not easy to understand or evaluate how they might be used in a given research context. The goal of the National Science Foundation-funded Virtual Learning Commons (VLC) is to improve awareness and understanding of emerging methodologies and technologies, facilitate individual and group evaluation of these, and trace the impact of innovations within and across teams, disciplines, and communities. The VLC is a Web-based social bookmarking site designed specifically to support knowledge exchange in research communities. It is founded on well-developed models of technology adoption, diffusion of innovation, and experiential learning. The VLC makes use of Web 2.0 (Social Web) and Web 3.0 (Semantic Web) approaches. Semantic Web approaches enable discovery of potentially relevant methods, models, and tools, while Social Web approaches enable collaborative learning about their function. The VLC is under development and the first release is expected Fall 2014.
Graphic methods for interpreting longitudinal dyadic patterns from repeated-measures actor-partner interdependence models.

PubMed

Perry, Nicholas S; Baucom, Katherine J W; Bourne, Stacia; Butner, Jonathan; Crenshaw, Alexander O; Hogan, Jasara N; Imel, Zac E; Wiltshire, Travis J; Baucom, Brian R W

2017-08-01

Researchers commonly use repeated-measures actor-partner interdependence models (RM-APIM) to understand how romantic partners change in relation to one another over time. However, traditional interpretations of the results of these models do not fully or correctly capture the dyadic temporal patterns estimated in RM-APIM. Interpretation of results from these models largely focuses on the meaning of single-parameter estimates in isolation from all the others. However, considering individual coefficients separately impedes the understanding of how these associations combine to produce an interdependent pattern that emerges over time. Additionally, positive within-person, or actor, effects are commonly misinterpreted as indicating growth from one time point to the next when they actually represent decline. We suggest that change-as-outcome RM-APIMs and vector field diagrams (VFDs) can be used to improve the understanding and presentation of dyadic patterns of association described by standard RM-APIMs. The current article briefly reviews the conceptual foundations of RM-APIMs, demonstrates how change-as-outcome RM-APIMs and VFDs can aid interpretation of standard RM-APIMs, and provides a tutorial in making VFDs using multilevel modeling. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
Mapping common aphasia assessments to underlying cognitive processes and their neural substrates

PubMed Central

Lacey, Elizabeth H.; Skipper-Kallal, LM; Xing, S; Fama, ME; Turkeltaub, PE

2017-01-01

Background Understanding the relationships between clinical tests, the processes they measure, and the brain networks underlying them, is critical in order for clinicians to move beyond aphasia syndrome classification toward specification of individual language process impairments. Objective To understand the cognitive, language, and neuroanatomical factors underlying scores of commonly used aphasia tests. Methods 25 behavioral tests were administered to a group of 38 chronic left hemisphere stroke survivors and a high resolution MRI was obtained. Test scores were entered into a principal components analysis to extract the latent variables (factors) measured by the tests. Multivariate lesion-symptom mapping was used to localize lesions associated with the factor scores. Results The principal components analysis yielded four dissociable factors, which we labeled Word Finding/Fluency, Comprehension, Phonology/Working Memory Capacity, and Executive Function. While many tests loaded onto the factors in predictable ways, some relied heavily on factors not commonly associated with the tests. Lesion symptom mapping demonstrated discrete brain structures associated with each factor, including frontal, temporal, and parietal areas extending beyond the classical language network. Specific functions mapped onto brain anatomy largely in correspondence with modern neural models of language processing. Conclusions An extensive clinical aphasia assessment identifies four independent language functions, relying on discrete parts of the left middle cerebral artery territory. A better understanding of the processes underlying cognitive tests and the link between lesion and behavior may lead to improved aphasia diagnosis, and may yield treatments better targeted to an individual’s specific pattern of deficits and preserved abilities. PMID:28135902
Gene expression metadata analysis reveals molecular mechanisms employed by Phanerochaete chrysosporium during lignin degradation and detoxification of plant extractives.

PubMed

Kameshwar, Ayyappa Kumar Sista; Qin, Wensheng

2017-10-01

Lignin, most complex and abundant biopolymer on the earth's surface, attains its stability from intricate polyphenolic units and non-phenolic bonds, making it difficult to depolymerize or separate from other units of biomass. Eccentric lignin degrading ability and availability of annotated genome make Phanerochaete chrysosporium ideal for studying lignin degrading mechanisms. Decoding and understanding the molecular mechanisms underlying the process of lignin degradation will significantly aid the progressing biofuel industries and lead to the production of commercially vital platform chemicals. In this study, we have performed a large-scale metadata analysis to understand the common gene expression patterns of P. chrysosporium during lignin degradation. Gene expression datasets were retrieved from NCBI GEO database and analyzed using GEO2R and Bioconductor packages. Commonly expressed statistically significant genes among different datasets were further considered to understand their involvement in lignin degradation and detoxification mechanisms. We have observed three sets of enzymes commonly expressed during ligninolytic conditions which were later classified into primary ligninolytic, aromatic compound-degrading and other necessary enzymes. Similarly, we have observed three sets of genes coding for detoxification and stress-responsive, phase I and phase II metabolic enzymes. Results obtained in this study indicate the coordinated action of enzymes involved in lignin depolymerization and detoxification-stress responses under ligninolytic conditions. We have developed tentative network of genes and enzymes involved in lignin degradation and detoxification mechanisms by P. chrysosporium based on the literature and results obtained in this study. However, ambiguity raised due to higher expression of several uncharacterized proteins necessitates for further proteomic studies in P. chrysosporium.
Information display: the weak link for NCW

NASA Astrophysics Data System (ADS)

Gilger, Mike

2006-05-01

The Global Information Grid (GIG) enables the dissemination of real-time data from any sensor/source as well as the distribution of that data immediately to recipients across the globe, resulting in better, faster, and more accurate decisions, reduced operational risk, and a more competitive war-fighting advantage. As a major component of Network Centric Warfare (NCW), the GIG seeks to provide the integrated information infrastructure necessary to connect the robust data streams from ConstellationNet, FORCENet, and LandWarNet to allow Joint Forces to move beyond Situational Awareness and into Situational Understanding. NCW will provide the Joint Forces a common situational understanding, a common operating picture, and any and all information necessary for rapid decision-making. However, with the exception of the 1994 introduction of the Military Standard 2525 "Common Warfighting Symbology," there has been no notable improvement in our ability to display information for accurate and rapid understanding. In fact, one of the notable problems associated with NCW is how to process the massive amount of newly integrated data being thrown at the warfighter: a significant human-machine interface challenge. The solution; a graphical language called GIFIC (Graphical Interface for Information Cognition) that can display thousands of data points simultaneously. Coupled with the new generation COP displays, GIFIC provides for the tremendous amounts of information-display required for effective NCW battlespace awareness requirements, offering instant insight into joint operations, tactical situations, and targeting necessities. GIFIC provides the next level of information-display necessary for a successful NCW, resulting in agile, high-performance, and highly competitive warfighters.
An Opportunity for Convergence? Understanding the Prevalence and Risk of Distracted Driving Through the Use of Crash Databases, Crash Investigations, and Other Approaches

PubMed Central

Angell, Linda S.

2014-01-01

A variety of methodologies for understanding the prevalence of distracted driving, its risk, and other aspects of driver secondary activity, have been used in the last 15 years. Although the current trend is toward naturalistic driving studies, each methodology contributes certain elements to a better understanding that could emerge from a convergence of these efforts. However, if differing methods are to contribute to a common and robust understanding of driver distraction, it is critical to understand the strengths and limitations of each method. This paper reviews several of the non-naturalistic methods. It suggests that “convergence science” – a more concerted and rigorous effort to bring different approaches together into an integrative whole – may offer benefits for identification and definition of issues and countermeasure development to improve driving safety. PMID:24776226
Pseudomonas aeruginosa Dose-Response and Bathing Water Infection

EPA Science Inventory

Pseudomonas aeruginosa is the most commonly identified opportunistic pathogen associated with pool acquired bather disease. To better understand why this microorganism poses this protracted problem we recently appraised P. aeruginosa pool risk management. Much is known about the ...
Do your nurses speak finance?

PubMed

Studer, Quint

2010-06-01

To ensure that financial and clinical leaders have the same perspective on the direction their organization is taking, hospitals should: Build a platform of common understanding. Connect to the"why". Be transparent. Give clinical leaders the tools they need. Create true collaboration.
Epidemiology of Endometrial Cancer Consortium (E2C2)

Cancer.gov

The Epidemiology of Endometrial Cancer Consortium studies the etiology of this common cancer and build on resources from existing studies by combining data across studies in order to advance the understanding of the etiology of this disease.

Models of Mental Functioning

DTIC Science & Technology

1989-05-14

Mental Retardation. Detterman, D. K. (in press). Common challenges in understanding human and artificial intelligence. [Review of Creative Intelligences...Limited. Sternberg, R. J., & Detterman, D. K. (1988). Oue es la inteligencia ? Enfoque actual de su naturaleza y definicion. Translation of What is
What Is Ethics in Research and Why Is It Important?

MedlinePlus

... common diseases to help prevent disease and improve human health. Explore Research Funding Opportunities Grants Grants Explore Grants ... health sciences to understand human disease and improve human health. Use the search box to see research highlights ...
Dehydropyrrolizidine alkaloid toxicity, cytotoxicity, and carcinogenicity

USDA-ARS?s Scientific Manuscript database

Dehyro-pyrrolizidine alkaloid (PA)-containing plants compose about 5% of the world’s flowering plants and they commonly poison livestock, wildlife and humans. Previous work has produced considerable understanding of PA toxicity, species susceptibility, conditions and routes of exposure, toxin metab...
Ingestions considered nontoxic.

PubMed

Mofenson, H C; Greensher, J; Caraccio, T R

1984-09-01

The authors have compiled a list of common household products and drugs that are frequently ingested by children and may be considered nontoxic unless taken deliberately or in large amounts. An understanding of the nontoxic ingestion should prevent overtreatment and decrease emergency room visits.
Understanding Papillary Renal Cell Carcinoma | Center for Cancer Research

Cancer.gov

Renal cell carcinoma (RCC), the most common form of kidney cancer in adults, is not a single disease but rather a collection of different tumor types driven by distinct genetic changes that arise within the same tissue.
Let's Stop Teaching About Sex (of the Flowering Plants)

ERIC Educational Resources Information Center

Davidson, John F.; Thelen, Leverne J

1969-01-01

Points out common misconceptions, especially the idea that pollination in flowering plants corresponds to fertilization in animals. Gives history of understanding of plant sexuality, then summarizes modern view. Suggests we teach accurately or not at all. (EB)
Bridging Cultures with Classroom Strategies.

ERIC Educational Resources Information Center

Rothstein-Fisch, Carrie; Greenfield, Patricia M.; Trumbull, Elise

1999-01-01

Collectivism, stressing family members' interdependence, is common to Latino cultures. In contrast, schools foster independence and individual achievement. To help teachers understand assumptions underlying these different values, the authors developed the "Bridging Cultures Project" as a research-based professional-development program.…
Progress in Emission Efficiency of Organic Light-Emitting Diodes: Basic Understanding and Its Technical Application

NASA Astrophysics Data System (ADS)

Tsutsui, Tetsuo; Takada, Noriyuki

2013-11-01

The technical history of when and how the basic understanding of the emission efficiency of organic light-emitting diodes (OLEDs) was established over the last 50 years is described. At first, our understanding of emission efficiency in single-crystal and thin-film electroluminescence (EL) devices in the early stages before the Eastman-Kodak breakthrough, that is, the introduction of the concept of multilayer structures, is examined. Then our contemplation travels from the Eastman-Kodak breakthrough towards the presently widely accepted concept of emission efficiency. The essential issues concerning the emission efficiency of OLEDs are summarized to help readers to obtain a common understanding of OLED efficiency problems, and detailed discussions on the primary factors that determine emission efficiency are given. Finally, some comments on remaining issues are presented.
Effective Methods of Teaching Moon Phases

NASA Astrophysics Data System (ADS)

Jones, Heather; Hintz, E. G.; Lawler, M. J.; Jones, M.; Mangrubang, F. R.; Neeley, J. E.

2010-01-01

This research investigates the effectiveness of several commonly used methods for teaching the causes of moon phases to sixth grade students. Common teaching methods being investigated are the use of diagrams, animations, modeling/kinesthetics and direct observations of moon phases using a planetarium. Data for each method will be measured by a pre and post assessment of students understanding of moon phases taught using one of the methods. The data will then be used to evaluate the effectiveness of each teaching method individually and comparatively, as well as the method's ability to discourage common misconceptions about moon phases. Results from this research will provide foundational data for the development of educational planetarium shows for the deaf or other linguistically disadvantage children.
Psoriasis.

PubMed

Nestle, Frank O

2008-01-01

Psoriasis is one of the most common chronic inflammatory disorders with a strong genetic background. Recent progress in the understanding of both the immunological as well as the genetic basis has provided an unprecedented opportunity to move scientific insights from the bench to bedside. Based on insights from laboratory research, targeted immunotherapies are now available for the benefit of patients suffering from psoriasis. The success of these therapies has validated insights into disease pathogenesis and also provides the opportunity to increase our understanding about the pathways underpinning autoimmune-type inflammation in the skin.
The Changing Face of Hypophosphatemic Disorders in the FGF-23 Era

PubMed Central

Lee, Janet Y.; Imel, Erik A.

2014-01-01

In the past decade, research in genetic disorders of hypophosphatemia has significantly expanded our understanding of phosphate metabolism. X-linked hypophosphatemia (XLH) is the most common inherited form of rickets due to renal phosphate wasting. Recent understanding of the mechanisms of disease and role of fibroblast growth factor 23 (FGF-23) in XLH and other hypophosphatemic disorders have opened new potential therapeutic avenues. We will discuss the current standard of treatment for XLH as well as promising future directions under study. PMID:23858620
Post-LASIK dry eye

PubMed Central

Shtein, Roni M

2011-01-01

Laser-assisted in situ keratomileusis (LASIK) is a frequently performed corneal refractive surgery with excellent refractive outcomes. The most common complication of LASIK is dry eyes, with virtually all patients developing some degree of dryness in the immediate postoperative period. Identifying preoperative dry eyes, and conscientious attention and treatment in the perioperative time period, can lead to enhanced patient satisfaction and more accurate visual outcomes. Improved understanding of the development of dry eyes after LASIK will advance our understanding of the complex pathophysiology of dry eye disease. PMID:22174730
Guiding the creation of knowledge and understanding in a virtual learning environment.

PubMed

Littleton, Karen; Whitelock, Denise

2004-04-01

This article reports findings from an in-depth case study investigating processes of teaching and learning within one tutorial group studying an e-learning course presented as part of the Open University's MA in Open and Distance Education. Drawing on contemporary sociocultural theory and research, the instructional techniques used by the tutor-moderator to guide the creation of "common knowledge" and the construction of understanding are explored. The significance of tutor contributions for fostering a supportive culture of enquiry is also discussed.
Communicating tobacco product harm: Compared to what?

PubMed

Kaufman, Annette R; Suls, Jerry M; Klein, William M P

2016-01-01

With the expansion of tobacco product options, a better understanding is needed of how information about the known and unknown risks of products is communicated to the public. Engaging in comparative processes is an common way for people to understand novel products, but the referent of comparison matters and can influence perceptions and behavior. This paper builds awareness of research from other disciplines, including decision science, marketing, and psychology, which can help inform research and tobacco control efforts. Published by Elsevier Ltd.
The history of craniotomy for headache treatment.

PubMed

Assina, Rachid; Sarris, Christina E; Mammis, Antonios

2014-04-01

Both the history of headache and the practice of craniotomy can be traced to antiquity. From ancient times through the present day, numerous civilizations and scholars have performed craniotomy in attempts to treat headache. Today, surgical intervention for headache management is becoming increasingly more common due to improved technology and greater understanding of headache. By tracing the evolution of the understanding of headache alongside the practice of craniotomy, investigators can better evaluate the mechanisms of headache and the therapeutic treatments used today.
Defining the genetic connection linking amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD).

PubMed

Lattante, Serena; Ciura, Sorana; Rouleau, Guy A; Kabashi, Edor

2015-05-01

Several genetic causes have been recently described for neurological diseases, increasing our knowledge of the common pathological mechanisms involved in these disorders. Mutation analysis has shown common causative factors for two major neurodegenerative disorders, ALS and FTD. Shared pathological and genetic markers as well as common neurological signs between these diseases have given rise to the notion of an ALS/FTD spectrum. This overlap among genetic factors causing ALS/FTD and the coincidence of mutated alleles (including causative, risk and modifier variants) have given rise to the notion of an oligogenic model of disease. In this review we summarize major advances in the elucidation of novel genetic factors in these diseases which have led to a better understanding of the common pathogenic factors leading to neurodegeneration. Copyright © 2015 Elsevier Ltd. All rights reserved.
Is It Oscar-Worthy? Children’s Metarepresentational Understanding of Acting

PubMed Central

Goldstein, Thalia R.; Bloom, Paul

2015-01-01

Although it is an essential aspect of one of the most common forms of entertainment, psychologists know almost nothing about how children understand the act of portraying a character in a realistic manner—realistic acting. Do children possess the sort of meta-theory of acting that adults possess? In two studies we find that, unlike adults, children between the ages of 3–5 do not think that a realistic actor is better at portraying a characteristic than a nonrealistic actor, nor do they prefer one to the other. As they develop, they come to understand that realistic acting is different from nonrealistic acting, but unlike adults, children think that a nonrealistic, pretense-like portrayal is more difficult to achieve than a realistic representation of an emotional or physical state. These findings show that children’s metarepresentational understanding of acting is relatively immature at age 5, and that their understanding of this specific domain of pretense lags behind their understanding of pretense in general. PMID:25761111
The United States and Japan pursue a common agenda.

PubMed

Westley, S B

1996-10-01

In July 1993, the US and Japan formed the "Common Agenda for Cooperation in Global Perspective," an economic alliance to promote health and human development, respond to challenges to global stability, protect the global environment, advance science and technology, and foster exchanges for mutual understanding. A Global Issues Initiative (GII) has been created within this framework to support family planning, HIV and sexually transmitted disease prevention and control efforts, maternal and child health, primary health care, and women's empowerment. Participation in the GII has led Japan to more than double the technical assistance it provides and to broaden its geographic focus from Asia to the entire developing world. The US continues to fund population and health programs in more than 50 countries. The Common Agenda grew out of a US-Japan development assistance policy consultation dialogue known as the "Honolulu process," which sought ways to promote mutual understanding among US and Japanese development assistance personnel (through international internships) and nongovernmental organizations and to identify specific areas for joint or parallel development projects. Cooperative activities are underway in the Philippines, Indonesia, Bangladesh, India, Ghana, Peru, Guatemala, Mexico, and Jamaica. Joint project evaluations have also taken place in Zambia and Ghana. The Common Agenda's Children's Health Initiative has supported such initiatives as achieving child immunization in the Newly Independent States and joint efforts to eradicate polio and micronutrient disorders. The Women in Development initiative enhances girls' education and assists women engaged in small-scale enterprises. After initial difficulties in agreeing on joint strategies, the Common Agenda has been an "overwhelmingly positive" experience with the potential to meet critical challenges, because Japan and the US account for 40% of all development assistance worldwide.
Metaproteomics of Microbiota in Naturally Fermented Soybean Paste, Da-jiang.

PubMed

Zhang, Ping; Zhang, Pengfei; Xie, Mengxi; An, Feiyu; Qiu, Boshu; Wu, Rina

2018-05-01

Da-jiang is a typical traditional fermented soybean product in China. At present, the proteins in da-jiang are needed to be explored. The composition and species of microbial proteins in traditional fermented da-jiang were analyzed by metaproteomics based on sodium dodecyl sulfonate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). The results showed that the number and variety of microbial proteins in the traditional fermented da-jiang from different regions were different. The production site influences the fermentation in da-jiang. Then we analyzed the functions of the microbial proteins identified in da-jiang, and found that they were mainly involved in the process of protein synthesis, glycometabolism and nucleic acid synthesis. In addtion, we compared the proteins composition in different da-jiang. There are 51 common proteins of naturally fermented da-jiang, and 25 common microbial sources. The main commonly microbial sources of fungal proteins are Saccharomyces cerevisiae and Schizosaccharomyces; the main commonly microbial sources of bacterial proteins are Enterococcus faecalis, Leuconostoc mesenteroides, Acinetobacter baumannii, and Bacillus subtilis. These common microbes play the predominant role in da-jiang fermentation. The present results help us to understand the fermentation of da-jiang and improve the quality and safety of final products in the future. The study illustrated metaproteome of microbiota in traditional fermented soybean paste, da-jiang, by sodium dodecyl sulfonate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). A method of extracting metaproteome from microbiota in da-jiang was attempted. The findings help to understand the fermentation of da-jiang and improve the quality and safety of da-jiang in fermented industry. © 2018 Institute of Food Technologists®.
DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The increasing scale-up of fast pyrolysis in North America and Europe, as well as the exploration and expansion of markets for the energy use of biocrude oils that now needs to take place, suggested that it was timely to convene an international meeting on the properties and combustion behavior of these oils. A common understanding of the state-of-the-art and technical and other challenges which need to be met during the commercialization of biocrude fuel use, can be achieved. The technical issues and understanding of combustion of these oils are rapidly being advanced through R&D in the United States, Canada, Europemore » and Scandinavia. It is obvious that for the maximum economic impact of biocrude, it will be necessary to have a common set of specifications so that oils can be used interchangeably with engines and combustors which require minimal modification to use these renewable fuels. Fundamental and applied studies being pursued in several countries are brought together in this workshop so that we can arrive at common strategies. In this way, both the science and the commercialization are advanced to the benefit of all, without detracting from the competitive development of both the technology and its applications. This United States-Canada-Finland collaboration has led to the two and one half day specialists meeting at which the technical basis for advances in biocrude development is discussed. The goal is to arrive at a common agenda on issues that cross national boundaries in this area. Examples of agenda items are combustion phenomena, the behavior of trace components . of the oil (N, alkali metals), the formation of NO{sub x}, in combustion, the need for common standards and environmental safety and health issues in the handling, storage and transportation of biocrudes.« less

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