Original blackandwhite print, VIEW OF UNFINISHED FACADE AND PORTION OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Original black-and-white print, VIEW OF UNFINISHED FACADE AND PORTION OF CURVED FACADE AT TWELFTH STREET - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

Original blackandwhite print, VIEW OF UNFINISHED FACADE AT ELEVENTH STREET ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Original black-and-white print, VIEW OF UNFINISHED FACADE AT ELEVENTH STREET AND STEPS FROM OLD POST OFFICE - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

Finding peace of mind when there still is so much left undone-A diary study on how job stress, competence need satisfaction, and proactive work behavior contribute to work-related rumination during the weekend.

PubMed

Weigelt, Oliver; Syrek, Christine J; Schmitt, Antje; Urbach, Tina

2018-05-21

Unfinished work tasks have been identified as a significant job-related stressor in recent occupational stress research. Extending this research, we examine how and when not finishing one's tasks by the end of the work week affects work-related rumination at the weekend. Drawing on control theory, we examined competence need satisfaction as a mediating mechanism that links unfinished tasks at the end of the work week to work-related rumination at the weekend. Furthermore, we scrutinized whether proactive work behavior within the work week may neutralize the detrimental effects of unfinished tasks on competence need satisfaction and rumination. Using diary methodology, we collected weekly observations from 58 employees at the beginning and at the end of the work week over a period of 12 consecutive weeks, yielding 377 matched observations. Multilevel modeling analyses provided evidence for the assumed indirect effect at the intraindividual level. Higher levels of unfinished tasks were associated with lower levels of competence need satisfaction during the weekend. Competence need satisfaction, in turn, was negatively related to work-related rumination. Proactive work behavior attenuated the detrimental effects of unfinished tasks on competence need satisfaction and rumination at the weekend. These results imply that proactive work behavior facilitates switching off mentally during the weekend as it may restore competence need satisfaction in the face of unfinished tasks. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Fractions, trees and unfinished business

NASA Astrophysics Data System (ADS)

Shraiman, Boris

In this talk, mourning the loss of a teacher and a dear friend, I would like to share some unfinished thoughts loosely connecting - via Farey fraction trees - Kadanoff's study of universality of quasi-periodic route to chaos with the effort to understand universal features of genealogical trees.

The Unfinished Agenda.

ERIC Educational Resources Information Center

Phillips, Madge

1981-01-01

Items on the unfinished agendas of society, education, and physical education include: (1) the war on human suffering; (2) the paradox of education as the equalizer of social differences, although it recognizes individual merit based on academic excellence; and (3) physical education as an agent of social change and responsibility. (JN)

76 FR 11757 - Drill Pipe From the People's Republic of China: Antidumping Duty Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... are finished drill pipe and drill collars without regard to the specific chemistry of the steel (i.e... included are unfinished drill collars (including all drill collar green tubes) and unfinished drill pipe (including drill pipe green tubes, which are tubes meeting the following description: seamless tubes with an...

13. INTERIOR VIEW OF GATE OPERATOR ROOM, SHOWING UNFINISHED CONCRETE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. INTERIOR VIEW OF GATE OPERATOR ROOM, SHOWING UNFINISHED CONCRETE WALLS AND SLIDE GATE OPERATORS, LOOKING NORTH. - Sacramento River Water Treatment Plant Intake Pier & Access Bridge, Spanning Sacramento River approximately 175 feet west of eastern levee on river; roughly .5 mile downstream from confluence of Sacramento & American Rivers, Sacramento, Sacramento County, CA

78 FR 45912 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and... Bearing Co., Ltd.'s (Tainai's) request for a new shipper review (NSR) of the antidumping duty order on tapered roller bearings and parts thereof, finished and unfinished (TRBs), from the People's Republic of...

4. November 1986. INTERIOR OF BUILDING FROM DOOR. (Note unfinished ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. November 1986. INTERIOR OF BUILDING FROM DOOR. (Note unfinished rammed earth walls; square holes are from joists used to hold wall forms together during construction. Stairs in view at left go to storage room below.) - Borough House, Dry Well Shelter, State Route 261 & Garners Ferry Road, Stateburg, Sumter County, SC

Evidence from Biochemical Pathways in Favor of Unfinished Evolution Rather than Intelligent Design

ERIC Educational Resources Information Center

Behrman, Edward J.; Marzluf, George A.

2004-01-01

An argument is made in favor of imperfect or unfinished evolution based on some metabolic pathways in which it seems that intelligent design would have done better. The case studies noted indicate the absence of highly intelligent design and are not intended as comprehensive collection but as a limited sample of inefficient situations in…

INTERIOR DETAIL, UNFINISHED SPACE TO THE ATTIC’S WEST, BEYOND THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR DETAIL, UNFINISHED SPACE TO THE ATTIC’S WEST, BEYOND THE NORTHWEST ATTIC CHAMBER. THIS VIEW CAPTURES THE TOP OF THE POLYGONAL BAY THAT PROTRUDED FROM THE WEST WALL OF THE ORIGINAL ESTATE HOUSE AT THE WOODLANDS, WHICH WAS ENCASED IN THE LATER 1780S RENOVATIONS AND ADDITIONS - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

Unfinished but Not yet Exhausted: A Review of Australian Middle Schooling

ERIC Educational Resources Information Center

Prosser, Brenton

2008-01-01

The state of Middle Schooling in many Western countries has been described as under threat, at a crossroads and like a wasteland. Within Australia, it has also been claimed that the past generation focus on Middle Schooling is unfinished and exhausted. But a Middle Schooling movement continues in Australia that provides examples of a way out of a…

Consequences of Delayed, Unfinished, or Missed Nursing Care During Labor and Birth.

PubMed

Simpson, Kathleen Rice; Lyndon, Audrey

: The purpose of this study was to examine the concept of delayed, unfinished, or missed nursing care when patient census and acuity exceed nurse staffing resources with nurses who care for women during labor and birth. Focus groups were held during which labor nurses were asked about aspects of nursing care that may be regularly delayed, unfinished, or completely missed during labor and birth, including possible reasons and potential consequences. Seventy-one labor nurses participated in 11 focus groups in 6 hospitals. Nurses focused on support and encouragement as aspects of care that they felt are essential but often not able to be performed when the unit is busy. Nurses seemed to assume technical features of care as a "given" in the background and not always noticed unless missed. They voiced concerns about risks to maternal and fetal well-being when they were short-staffed. Potential outcomes were discussed including cesarean birth, depressed infants at birth, hemorrhage, and negative effects on patient satisfaction, successful breast-feeding, and the overall patient experience. When essential aspects of nursing care are delayed, unfinished, or completely missed, there are potentially negative implications for numerous patient outcomes and patient safety is at risk.

Scenarios for Education in the Twenty-First Century: Synthesis of an Unfinished Dialogue and Questions for Further Progress

ERIC Educational Resources Information Center

Prospects: Quarterly Review of Comparative Education, 2004

2004-01-01

This article presents a synthesis of an unfinished dialogue on Organisation for Economic Co-operation and Development's (OECD) scenarios for education in the twenty-first century and on the position of education that these scenarios question. The first part of this article brings together some of the core considerations put forward by the members…

Genetic interactions of the unfinished flower development (ufd) mutant support a significant role of the tomato UFD gene in regulating floral organogenesis.

PubMed

Poyatos-Pertíñez, Sandra; Quinet, Muriel; Ortíz-Atienza, Ana; Bretones, Sandra; Yuste-Lisbona, Fernando J; Lozano, Rafael

2016-09-01

Genetic interactions of UFD gene support its specific function during reproductive development of tomato; in this process, UFD could play a pivotal role between inflorescence architecture and flower initiation genes. Tomato (Solanum lycopersicum L.) is a major vegetable crop that also constitutes a model species for the study of plant developmental processes. To gain insight into the control of flowering and floral development, a novel tomato mutant, unfinished flower development (ufd), whose inflorescence and flowers were unable to complete their normal development was characterized using double mutant and gene expression analyses. Genetic interactions of ufd with mutations affecting inflorescence fate (uniflora, jointless and single flower truss) were additive and resulted in double mutants displaying the inflorescence structure of the non-ufd parental mutant and the flower phenotype of the ufd mutant. In addition, ufd mutation promotes an earlier inflorescence meristem termination. Taken together, both results indicated that UFD is not involved in the maintenance of inflorescence meristem identity, although it could participate in the regulatory system that modulates the rate of meristem maturation. Regarding the floral meristem identity, the falsiflora mutation was epistatic to the ufd mutation even though FALSIFLORA was upregulated in ufd inflorescences. In terms of floral organ identity, the ufd mutation was epistatic to macrocalyx, and MACROCALYX expression was differently regulated depending on the inflorescence developmental stage. These results suggest that the UFD gene may play a pivotal role between the genes required for flowering initiation and inflorescence development (such as UNIFLORA, FALSIFLORA, JOINTLESS and SINGLE FLOWER TRUSS) and those required for further floral organ development such as the floral organ identity genes.

Controlling, Modeling, Consensus, and Substance Use(r) Policy Intervention: Unfinished Business.

PubMed

Ferguson, Brian

2015-01-01

This article looks at certain aspects of unfinished business in substance use policy from the economist's perspective. It takes the view that in tackling a policy issue such as cigarette smoking, it is likely to be necessary to use a portfolio of policy tools, rather than on just one tool, and that it is likely to be necessary to accept that complete elimination of the activity being considered will almost certainly cost more than it is worth-we will probably always have to live with some nonzero level of such activities.

Family planning: the unfinished agenda.

PubMed

Cleland, John; Bernstein, Stan; Ezeh, Alex; Faundes, Anibal; Glasier, Anna; Innis, Jolene

2006-11-18

Promotion of family planning in countries with high birth rates has the potential to reduce poverty and hunger and avert 32% of all maternal deaths and nearly 10% of childhood deaths. It would also contribute substantially to women's empowerment, achievement of universal primary schooling, and long-term environmental sustainability. In the past 40 years, family-planning programmes have played a major part in raising the prevalence of contraceptive practice from less than 10% to 60% and reducing fertility in developing countries from six to about three births per woman. However, in half the 75 larger low-income and lower-middle income countries (mainly in Africa), contraceptive practice remains low and fertility, population growth, and unmet need for family planning are high. The cross-cutting contribution to the achievement of the Millennium Development Goals makes greater investment in family planning in these countries compelling. Despite the size of this unfinished agenda, international funding and promotion of family planning has waned in the past decade. A revitalisation of the agenda is urgently needed. Historically, the USA has taken the lead but other governments or agencies are now needed as champions. Based on the sizeable experience of past decades, the key features of effective programmes are clearly established. Most governments of poor countries already have appropriate population and family-planning policies but are receiving too little international encouragement and funding to implement them with vigour. What is currently missing is political willingness to incorporate family planning into the development arena.

The struggle for women's rights is an unfinished business. Ms. Patricia M. Sarenas, M.P. Men's support for women's empowerment essential. -- Ms. Rechin Narangerel, M.P.

PubMed

1999-01-01

Ms. Patricia M. Sarenas and Ms. Rechin Narangerel, representative from the Philippines and Mongolia respectively, addressed the issue of women's right during the 6th General Assembly of Asian Forum of Parliamentarians on Population and development. According to Ms. Sarenas, the struggle for women's rights and gender equity, peace and development was an unfinished business. She stressed that women parliamentarians had a bigger role to play in defying condescension, criticize patronizing attitudes, assert women's issues and voice women's concerns, and insist on more meaningful participation of women at all levels. They must also stand unafraid to denounce loud and clear, violations of human rights, especially in Asia. Ms. Sarenas's greatest hope was that parliamentarians would continue to explore the different experiences and perspectives within the solidarity of their shared struggles in Asia as a group of people who were in a position to do something for women and men everywhere. On the other hand, Ms. Narangerel noted that Mongolia had always had a tradition of respect for women's status and conditions as manifested by the relatively high rates of literacy, access to health services and employment opportunities. Women's NGO were very active in sensitizing high-level government officials on the need to establish mechanisms to accelerate women's equal participation and equitable representation at all levels of the political process and public life. On her last note, she made mention of the importance of men's support for women's empowerment.

Banting Lecture 2009: An Unfinished Journey: Molecular Pathogenesis to Prevention of Type 1A Diabetes

PubMed Central

Eisenbarth, George S.

2010-01-01

The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made significant, long-term contributions to the understanding of diabetes, its treatment, and/or prevention. The award is named after Nobel Prize winner Sir Frederick Banting, who codiscovered insulin treatment for diabetes. Dr. Eisenbarth received the American Diabetes Association's Banting Medal for Scientific Achievement at the Association's 69th Scientific Sessions, June 5–9, 2009, in New Orleans, Louisiana. He presented the Banting Lecture, An Unfinished Journey—Type 1 Diabetes—Molecular Pathogenesis to Prevention, on Sunday, June 7, 2009. PMID:20350969

How unfinished business from S-phase affects mitosis and beyond

PubMed Central

Mankouri, Hocine W; Huttner, Diana; Hickson, Ian D

2013-01-01

The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps, each of which must be completed before the next one is initiated. However, emerging evidence suggests that incompletely replicated, or unresolved, chromosomes from S-phase can persist into mitosis, where they present a potential threat to the faithful segregation of sister chromatids. In this review, we provide an overview of the different classes of loci where this ‘unfinished S-phase business' can lead to a variety of cytogenetically distinct DNA structures throughout the various steps of mitosis. Furthermore, we discuss the potential ways in which cells might not only tolerate this inevitable aspect of chromosome biology, but also exploit it to assist in the maintenance of genome stability. PMID:24065128

How unfinished business from S-phase affects mitosis and beyond.

PubMed

Mankouri, Hocine W; Huttner, Diana; Hickson, Ian D

2013-10-16

The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps, each of which must be completed before the next one is initiated. However, emerging evidence suggests that incompletely replicated, or unresolved, chromosomes from S-phase can persist into mitosis, where they present a potential threat to the faithful segregation of sister chromatids. In this review, we provide an overview of the different classes of loci where this 'unfinished S-phase business' can lead to a variety of cytogenetically distinct DNA structures throughout the various steps of mitosis. Furthermore, we discuss the potential ways in which cells might not only tolerate this inevitable aspect of chromosome biology, but also exploit it to assist in the maintenance of genome stability.

UNFINISHED JOURNEY Project. Quarterly report, September 1994--December 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-02-01

In September, 1994, the U.S. Department of Energy (Nevada Operations Office) made a $199,708 grant (through the Mathematics, Science, and Technology Education Program), to the UNFINISHED JOURNEY Project. The Project began in April, 1994, to develop and implement an innovative model of student outreach by San Jose State University (SJSU) to underserved, underrepresented student populations of the East Side Union High School District (ESUHSD). The Project was formed by a consortium involving SJSU, ESUHSD, some 20 private sector organizations (foundations/corporations), numerous local community/professional organizations, and approximately 100 private funders. This proposal to the U.S. Department of Energy was to havemore » the Department join this unique partnership to focus University outreach to underserved student populations to pursue careers in mathematics, science, and technology.« less

Adaptation of sensor morphology: an integrative view of perception from biologically inspired robotics perspective

PubMed Central

Nurzaman, Surya G.

2016-01-01

Sensor morphology, the morphology of a sensing mechanism which plays a role of shaping the desired response from physical stimuli from surroundings to generate signals usable as sensory information, is one of the key common aspects of sensing processes. This paper presents a structured review of researches on bioinspired sensor morphology implemented in robotic systems, and discusses the fundamental design principles. Based on literature review, we propose two key arguments: first, owing to its synthetic nature, biologically inspired robotics approach is a unique and powerful methodology to understand the role of sensor morphology and how it can evolve and adapt to its task and environment. Second, a consideration of an integrative view of perception by looking into multidisciplinary and overarching mechanisms of sensor morphology adaptation across biology and engineering enables us to extract relevant design principles that are important to extend our understanding of the unfinished concepts in sensing and perception. PMID:27499843

Unfinished Business: Evolution of the MHC and the Adaptive Immune System of Jawed Vertebrates.

PubMed

Kaufman, Jim

2018-04-26

The major histocompatibility complex (MHC) is a large genetic region with many genes, including the highly polymorphic classical class I and II genes that play crucial roles in adaptive as well as innate immune responses. The organization of the MHC varies enormously among jawed vertebrates, but class I and II genes have not been found in other animals. How did the MHC arise, and are there underlying principles that can help us to understand the evolution of the MHC? This review considers what it means to be an MHC and the potential importance of genome-wide duplication, gene linkage, and gene coevolution for the emergence and evolution of an adaptive immune system. Then it considers what the original antigen-specific receptor and MHC molecule might have looked like, how peptide binding might have evolved, and finally the importance of adaptive immunity in general.

A strategic approach to the unfinished fortification agenda: feasibility, costs, and cost-effectiveness analysis of fortification programs in 48 countries.

PubMed

Fiedler, John L; Macdonald, Barbara

2009-12-01

Food fortification is a promising strategy for combating micronutrient deficiencies, which plague one-third of the world's population. Which foods to fortify, with which micronutrients, and in which countries remain essential questions that to date have not been addressed at the global level. To provide a tool for international agencies to identify and organize the next phase of the unfinished global fortification agenda by prioritizing roughly 250 potential interventions in 48 priority countries. By explicitly defining the structure and operations of the fortification interventions in a detailed and transparent manner, and incorporating a substantial amount of country-specific data, the study also provides a potentially useful starting point for policy discussions in each of the 48 countries, which--it is hoped--will help to catalyze the development of public-private partnerships and accelerate the introduction of fortification and reduction of micronutrient deficiencies. Forty-eight high-priority countries were identified, and the feasibility of fortifying vegetable oil and sugar with vitamin A and fortifying wheat flour and maize flour with two alternative multiple micronutrient formulations was assessed. One hundred twenty-two country-, food-, and fortification formulation-specific interventions were assessed to be feasible, and the costs of each intervention were estimated. Assuming a 30% reduction in the micronutrient deficiencies of the persons consuming the food, the number of disability-adjusted life years (DALYs) saved by each of the programs was estimated. The cost per DALY saved was calculated for each of the 122 interventions, and the interventions were rank-ordered by cost-effectiveness. It is estimated that the 60 most cost-effective interventions would carry a 10-year price tag of US$1 billion and have costs per DALY saved ranging from US$1 to US$134. The single "best bet" intervention--i.e., the most cost-effective intervention--in each of the 48 countries was identified. This study provides a detailed, transparent, evidence-based approach to defining and estimating the costs and cost-effectiveness of the unfinished global fortification agenda in the 48 priority countries. Other considerations in designing a strategic approach to the unfinished global fortification agenda are also discussed.

The Living Cosmos

NASA Astrophysics Data System (ADS)

Impey, Chris

2011-06-01

Preface; 1. The unfinished revolution; 2. Life's origins; 3. Extreme life; 4. Shaping evolution; 5. Living in the Solar System; 6. Distant worlds; 7. Are we alone?; Notes; Glossary; Reading list; Media resources; Illustration credits; Index.

Original blackandwhite print, VIEW OF THIRD FLOOR OFFICE AT TWELFTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Original black-and-white print, VIEW OF THIRD FLOOR OFFICE AT TWELFTH STREET UNFINISHED FACADE - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

4. INTERIOR OF ABANDONED SANTA ANA CANAL TUNNEL, SHOWING CEMENT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. INTERIOR OF ABANDONED SANTA ANA CANAL TUNNEL, SHOWING CEMENT TROUGH FLOOR AND UNFINISHED GRANITE ROOF. VIEW TO SOUTHWEST. - Santa Ana River Hydroelectric System, Abandoned Tunnel, Redlands, San Bernardino County, CA

22 CFR 121.10 - Forgings, castings, and machined bodies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... STATES MUNITIONS LIST Enumeration of Articles § 121.10 Forgings, castings, and machined bodies. The U.S. Munitions List controls as defense articles those forgings, castings, and other unfinished products, such as...

27 CFR 17.185 - Requirements for intermediate products and unfinished nonbeverage products.

Code of Federal Regulations, 2010 CFR

2010-04-01

... nonbeverage products. The manufacturer may choose either method of accounting for such self-manufactured... subsidiary corporations, regardless of any corporate (or other) relationship, and even if the stock of both...

7 CFR 28.956 - Prescribed fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... reflectance and yellowness in terms of Rd and +b values as based on the Nickerson-Hunter Cotton Colorimeter on... unfinished, bleached and dyed cotton samples, using a Hunterlab Colorimeter, Model 25 M-3. The color values...

Unfinished Business.

ERIC Educational Resources Information Center

Lehman, Paul R.

2000-01-01

Explores arts education policies focusing on achievements, such as the inclusion of music and visual arts in schools, development of the arts education standards; and the failures, such as the inability of the arts to overcome the perception of being a frill. (CMK)

Human Relationships at Work in Organisations.

ERIC Educational Resources Information Center

Clarkson, Petruska; Shaw, Patricia

1992-01-01

Identifies five types of relationships at work: the unfinished, working alliance, developmental, personal, and transpersonal. For each type, the following are described: contribution to the organization, human motivation, signs of dysfunction, relationship skill needs, and counseling needs. (SK)

49 CFR 195.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... Petroleum means crude oil, condensate, natural gasoline, natural gas liquids, and liquefied petroleum gas... crude oil, unfinished oils, natural gas liquids, blend stocks and other miscellaneous hydrocarbon... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

49 CFR 195.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... representative thereof. Petroleum means crude oil, condensate, natural gasoline, natural gas liquids, and... distilling and processing of crude oil, unfinished oils, natural gas liquids, blend stocks and other... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

49 CFR 195.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... representative thereof. Petroleum means crude oil, condensate, natural gasoline, natural gas liquids, and... distilling and processing of crude oil, unfinished oils, natural gas liquids, blend stocks and other... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

49 CFR 195.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... Petroleum means crude oil, condensate, natural gasoline, natural gas liquids, and liquefied petroleum gas... crude oil, unfinished oils, natural gas liquids, blend stocks and other miscellaneous hydrocarbon... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

49 CFR 195.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... Petroleum means crude oil, condensate, natural gasoline, natural gas liquids, and liquefied petroleum gas... crude oil, unfinished oils, natural gas liquids, blend stocks and other miscellaneous hydrocarbon... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY...

75 FR 72801 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

...: Effective Date: November 26, 2010. FOR FURTHER INFORMATION CONTACT: Brendan Quinn or Trisha Tran, AD/CVD...: November 18, 2010. Susan H. Kuhbach, Acting Deputy Assistant Secretary for Antidumping and Countervailing...

77 FR 60476 - Sunshine Act Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... Business'') and its accompanying online toolkit. Only the Governance and Planning Committee will provide..., specific to suggestions regarding the focus, findings, conclusions, and recommendations of it 2013 Progress Report. The policy briefing on NCD's ``Deinstitutionalization: Unfinished Business'' policy paper will...

24 CFR 3280.203 - Flame spread limitations and fire protection requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... hardboard, (2) Flame-spread rating-25 to 200, (i) Painted metal; (ii) Mineral-base acoustic tile; (iii) 5/16-inch or thicker unfinished gypsum wallboard (both latex- or alkyd-painted); and (iv) Ceramic tile. (The...

24 CFR 3280.203 - Flame spread limitations and fire protection requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... hardboard, (2) Flame-spread rating-25 to 200, (i) Painted metal; (ii) Mineral-base acoustic tile; (iii) 5/16-inch or thicker unfinished gypsum wallboard (both latex- or alkyd-painted); and (iv) Ceramic tile. (The...

24 CFR 3280.203 - Flame spread limitations and fire protection requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... hardboard, (2) Flame-spread rating-25 to 200, (i) Painted metal; (ii) Mineral-base acoustic tile; (iii) 5/16-inch or thicker unfinished gypsum wallboard (both latex- or alkyd-painted); and (iv) Ceramic tile. (The...

24 CFR 3280.203 - Flame spread limitations and fire protection requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... hardboard, (2) Flame-spread rating-25 to 200, (i) Painted metal; (ii) Mineral-base acoustic tile; (iii) 5/16-inch or thicker unfinished gypsum wallboard (both latex- or alkyd-painted); and (iv) Ceramic tile. (The...

24 CFR 3280.203 - Flame spread limitations and fire protection requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... hardboard, (2) Flame-spread rating-25 to 200, (i) Painted metal; (ii) Mineral-base acoustic tile; (iii) 5/16-inch or thicker unfinished gypsum wallboard (both latex- or alkyd-painted); and (iv) Ceramic tile. (The...

The Southern Glacial Maximum 65,000 years ago and its Unfinished Termination

NASA Astrophysics Data System (ADS)

Schaefer, Joerg M.; Putnam, Aaron E.; Denton, George H.; Kaplan, Michael R.; Birkel, Sean; Doughty, Alice M.; Kelley, Sam; Barrell, David J. A.; Finkel, Robert C.; Winckler, Gisela; Anderson, Robert F.; Ninneman, Ulysses S.; Barker, Stephen; Schwartz, Roseanne; Andersen, Bjorn G.; Schluechter, Christian

2015-04-01

Glacial maxima and their terminations provide key insights into inter-hemispheric climate dynamics and the coupling of atmosphere, surface and deep ocean, hydrology, and cryosphere, which is fundamental for evaluating the robustness of earth's climate in view of ongoing climate change. The Last Glacial Maximum (LGM, ∼26-19 ka ago) is widely seen as the global cold peak during the last glacial cycle, and its transition to the Holocene interglacial, dubbed 'Termination 1 (T1)', as the most dramatic climate reorganization during this interval. Climate records show that over the last 800 ka, ice ages peaked and terminated on average every 100 ka ('100 ka world'). However, the mechanisms pacing glacial-interglacial transitions remain controversial and in particular the hemispheric manifestations and underlying orbital to regional driving forces of glacial maxima and subsequent terminations remain poorly understood. Here we show evidence for a full glacial maximum in the Southern Hemisphere 65.1 ± 2.7 ka ago and its 'Unfinished Termination'. Our 10Be chronology combined with a model simulation demonstrates that New Zealand's glaciers reached their maximum position of the last glacial cycle during Marine Isotope Stage-4 (MIS-4). Southern ocean and greenhouse gas records indicate coeval peak glacial conditions, making the case for the Southern Glacial Maximum about halfway through the last glacial cycle and only 15 ka after the last warm period (MIS-5a). We present the hypothesis that subsequently, driven by boreal summer insolation forcing, a termination began but remained unfinished, possibly because the northern ice sheets were only moderately large and could not supply enough meltwater to the North Atlantic through Heinrich Stadial 6 to drive a full termination. Yet the Unfinished Termination left behind substantial ice on the northern continents (about 50% of the full LGM ice volume) and after another 45 ka of cooling and ice sheet growth the earth was at inter-hemispheric Last Glacial Maximum configuration, when similar orbital forcing hit maximum-size northern ice sheets and ushered in T1 and thus the ongoing interglacial. This argument highlights the critical role of full glacial conditions in both hemispheres for terminations and implies that the Southern Hemisphere climate could transition from interglacial to full glacial conditions in about 15,000 years, while the Northern Hemisphere and its continental ice-sheets required half a glacial cycle.

75 FR 49891 - Drill Pipe from the People's Republic of China: Notice of Preliminary Affirmative Determination...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... non-API specifications, whether finished or unfinished (including green tubes suitable for drill pipe), without regard to the specific chemistry of the steel (i.e., carbon, stainless steel, or other alloy steel...

76 FR 6762 - Drill Pipe From the People's Republic of China: Amended Final Determination of Critical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-08

... the specific chemistry of the steel (i.e., carbon, stainless steel, or other alloy steel), and without... collar green tubes) and unfinished drill pipe (including drill pipe green tubes, which are tubes meeting...

Unfinished Business at North Carolina.

ERIC Educational Resources Information Center

Williams, Randall

1978-01-01

The controversy over Black admissions at the University of North Carolina at Chapel Hill is described, which has called into question such areas as quotas, special admissions policies, minority recruiting, and the impact on Black universities of increased Black enrollment at White institutions. (LBH)

Southeast Arizona Land Exchange and Conservation Act of 2013

THOMAS, 113th Congress

Rep. Gosar, Paul A. [R-AZ-4

2013-02-14

House - 09/26/2013 Committee of the Whole House on the state of the Union rises leaving H.R. 687 as unfinished business. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

75 FR 57443 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, from the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-21

...: Brendan Quinn or Trisha Tran, AD/CVD Operations, Import Administration, International Trade Administration... pursuant to sections 751(a) and 777(i) of the Act. Dated: September 15, 2010. Susan H. Kuhbach, Acting...

[The psychoanalytic interview of slum dwellers in Lima].

PubMed

Rodríguez Rabanal, C

1990-07-01

A large, as yet unfinished project conducted by the "Centro Psicoanálisis y Sociedad" concerns the use of psychoanalytic methods in social research. Case excerpts are presented to illustrate typical forms of the subjective processing of migration and marginalization.

Pollen dispersal by catapult: Experiments of Lyman J. Briggs on the flower of mountain laurel

USGS Publications Warehouse

Nimmo, John R.; Hermann, Paula M.; Kirkham, M.B.; Landa, Edward R.

2014-01-01

The flower of Kalmia latifolia L. employs a catapult mechanism that flings its pollen to considerable distances. Physicist Lyman J. Briggs investigated this phenomenon in the 1950s after retiring as longtime director of the National Bureau of Standards, attempting to explain how hydromechanical effects inside the flower’s stamen could make it possible. Briggs’s unfinished manuscript implies that liquid under negative pressure generates stress, which, superimposed on the stress generated from the flower’s growth habit, results in force adequate to propel the pollen as observed. With new data and biophysical understanding to supplement Briggs’s experimental results and research notes, we show that his postulated negative-pressure mechanism did not play the exclusive and crucial role that he credited to it, though his revisited investigation sheds light on various related processes. Important issues concerning the development and reproductive function of Kalmia flowers remain unresolved, highlighting the need for further biophysical advances.

76 FR 43262 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-20

... preliminary intent to rescind the new shipper review (``NSR'') of Xiang Yang Automobile Bearing Co., Ltd... Rescind the New Shipper Review of Xiang Yang Automobile Bearing Co., Ltd. (``ZXY''), dated June 17, 2011...

77 FR 40579 - Tapered Roller Bearings and Parts Thereof, Finished or Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... explained in the legislative history of the Omnibus Trade and Competitiveness Act of 1988, the Department... Google Maps: https://maps.google.com . The rates were in effect prior to the POR, so we adjusted them to...

Reducing assembly complexity of microbial genomes with single-molecule sequencing

USDA-ARS?s Scientific Manuscript database

Genome assembly algorithms cannot fully reconstruct microbial chromosomes from the DNA reads output by first or second-generation sequencing instruments. Therefore, most genomes are left unfinished due to the significant resources required to manually close gaps left in the draft assemblies. Single-...

9. Historic American Buildings Survey, Photographed by Daniel Cathcart March ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey, Photographed by Daniel Cathcart March 8th, 1934 INTERIOR VIEW OF WINDOW IN GARAGE LEFT UNFINISHED AT THE TIME OF RENOVATION SHOWING ORIGINAL ADOBE CONSTRUCTION. - Casa de los Cerritos, 4600 American Avenue, Long Beach, Los Angeles County, CA

Unfinished Business: Subjectivity and Supervision

ERIC Educational Resources Information Center

Green, Bill

2005-01-01

Within the now burgeoning literature on doctoral research education, postgraduate research supervision continues to be a problematical issue, practically and theoretically. This paper seeks to explore and understand supervision as a distinctive kind of pedagogic practice. Informed by a larger research project, it draws on poststructuralism,…

Permissible weight limits for construction vehicles on finished and unfinished pavements : final report.

DOT National Transportation Integrated Search

1979-01-01

The report summarizes studies directed at developing guidelines for controlling the use of partially completed pavements by heavy construction equipment. It is shown that the damaging effects of flotation tires may be analyzed in the same manner as t...

An Unfinished Experiment

ERIC Educational Resources Information Center

White, Stephen

1978-01-01

The author's firsthand account of the genesis and effects of "One Nation Indivisible?," a 1968 educational television documentary on the assassination of Martin Luther King and race relations, includes his observations on the problems and the potential of television as a continuing element in the educational system. (Author/DS)

Advocating for sexual rights at the UN: the unfinished business of global development.

PubMed

Ali, Saida; Kowalski, Shannon; Silva, Paul

2015-11-01

Twenty years ago, governments agreed that the right to have control over and decide freely and responsibly on all matters related to one's sexuality, free from coercion, discrimination and violence, is a fundamental human right. Since then, many aspects of sexual rights have been agreed by consensus at the global level, but the term "sexual rights" itself continues to be removed from negotiated outcomes and left out of international agreements, often at the last stages of negotiations. This commentary represents our point of view on the unfinished business of the UN with regards to the fight for sexual rights. Our perspective draws from lessons learned in cross-movement organizing in various regional UN spaces and outlines some of the tactics by conservative forces to push sexual rights to the periphery. The article reaffirms the position that broadening the debate and concepts surrounding sexual rights to be more inclusive, has enormous transformational potential and should inform collective advocacy efforts moving forward. Copyright © 2015 Elsevier Inc. All rights reserved.

37 CFR 10.48 - Sharing legal fees.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the practitioner's firm, partner, or associate may provide for the payment of money, over a reasonable... persons. (b) A practitioner who undertakes to complete unfinished legal business of a deceased... is based in whole or in part on a profit-sharing arrangement, providing such plan does not circumvent...

37 CFR 10.48 - Sharing legal fees.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the practitioner's firm, partner, or associate may provide for the payment of money, over a reasonable... persons. (b) A practitioner who undertakes to complete unfinished legal business of a deceased... is based in whole or in part on a profit-sharing arrangement, providing such plan does not circumvent...

37 CFR 10.48 - Sharing legal fees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the practitioner's firm, partner, or associate may provide for the payment of money, over a reasonable... persons. (b) A practitioner who undertakes to complete unfinished legal business of a deceased... is based in whole or in part on a profit-sharing arrangement, providing such plan does not circumvent...

Short-Term Energy Outlook Model Documentation: Other Petroleum Products Consumption Model

EIA Publications

2011-01-01

The other petroleum product consumption module of the Short-Term Energy Outlook (STEO) model is designed to provide U.S. consumption forecasts for 6 petroleum product categories: asphalt and road oil, petrochemical feedstocks, petroleum coke, refinery still gas, unfinished oils, and other miscvellaneous products

77 FR 2271 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and...: Import Administration, International Trade Administration, Department of Commerce. SUMMARY: On July 13, 2011, the Department of Commerce (``Department'') published the preliminary results and intent to...

Biology Education in the United States: The Unfinished Century.

ERIC Educational Resources Information Center

Bybee, Rodger W.

2002-01-01

Adresses five themes basic to biology education: (1) increased recognition of advances in the science of learning; (2) implementation of scientific ideas and technological innovations; (3) incorporation of science- and technology-related issues; (4) elaboration of global perspectives; and (5) professional community and civil discourse. (MM)

11. VIEW OF STARBOARD ELEVATION OF STERN (WITHOUT SCALE STICK), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. VIEW OF STARBOARD ELEVATION OF STERN (WITHOUT SCALE STICK), SHOWING WHEELHOUSE, DUCKTAIL, AND RUDDER ASSEMBLY; CRANE AT LEFT POSITIONED FOR REMOVAL OF WHEELHOUSE; UNFINISHED FERRO-CONCRETE HULL OF UNKNOWN VESSEL IN BACKGROUND - Bugeye "Louise Travers", Intersection of Routes 2 & 4, Solomons, Calvert County, MD

Gaudi Goes Green

ERIC Educational Resources Information Center

Thomas, Suzanne

2011-01-01

When the author traveled to the city of Barcelona, Spain to see the still-unfinished La Sagrada Familia in person, she marveled at the magical genius of Antoni Gaudi's masterpiece. Inspired by Gaudi's whimsical tile work and cathedral towers, the author developed an art project that engages students in a creative experience, which combined art…

ISEA 2007 Panel: Integration of Better Exposure Characterizations into Disaster Preparedness for Responders and the Public

EPA Science Inventory

An expert panel was convened in October 2007 at the International Society for Exposure Analysis (ISEA) Annual Meeting in Durham, NC, entitled “The Path Forward in Disaster Preparedness Since WTC—Exposure Characterization and Mitigation: Substantial Unfinished Business!” The pane...

Toward a Better Understanding of Within-School Minority Student Resegregation: A Research Agenda.

ERIC Educational Resources Information Center

Meier, Ken J.; And Others

Despite years of litigation the desegregation of United States public schools remains unfinished. Even after court-ordered desegregation, a school district may remain segregated through various practices such as ability grouping and selective discipline of minority children. These second generation discrimination or resegregation practices have an…

Education for Sustainable Development: Connecting the Dots for Sustainability

ERIC Educational Resources Information Center

Gokool-Ramdoo, Sushita; Rumjaun, Anwar Bhai

2017-01-01

Critical pedagogy, practitioner experience and a regulatory perspective are employed to scrutinize the notion of Education for Sustainable Development (ESD) as it occurs in the literature. They promote understanding of the challenges impeding the completion of unfinished ESD businesses. In response to practitioner-expressed needs, this paper…

78 FR 40692 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and..., International Trade Administration, Department of Commerce. SUMMARY: The Department of Commerce (Department) is... Department selected one mandatory respondent for individual examination (i.e., Changshan Peer Bearing Co. Ltd...

77 FR 24179 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-23

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and... Trade Administration, Department of Commerce. DATES: Effective Date: April 23, 2012. SUMMARY: On January 17, 2012, the Department of Commerce (``Department'') published the final results of the antidumping...

37 CFR 201.2 - Information given by the Copyright Office.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Copyright Office. 201.2 Section 201.2 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF... requests by the public for information in the in-process and open unfinished business files should be made... of pending applications and open correspondence files by someone other than the copyright claimant...

Immigration to the U.S.: The Unfinished Story.

ERIC Educational Resources Information Center

Bouvier, Leon F.; Gardner, Robert W.

1986-01-01

Several times early in the twentieth century total annual immigration exceeded one million people. Current immigration figures may match those record totals. Since 1979, legal immigrants have averaged 566,000 a year; newly arrived refugees and asylees approved have averaged 135,000; and the "settled" illegal immigrant population may be…

Achieving Equity in Higher Education: The Unfinished Agenda

ERIC Educational Resources Information Center

Astin, Alexander W.; Astin, Helen S.

2015-01-01

In this retrospective account of their scholarly work over the past 45 years, Alexander and Helen Astin show how the struggle to achieve greater equity in American higher education is intimately connected to issues of character development, leadership, civic responsibility, and spirituality. While shedding some light on a variety of questions…

The Unfinished Business of Learning.

ERIC Educational Resources Information Center

Florida State Dept. of Education, Tallahassee. Bureau of Adult/Community Education.

A Florida task force investigated the educational levels of the state's elderly population. Data collection included the construction of statistical summaries, examination of existing documents (including a prior study of education and the elderly), and a review of the literature on aging. The following information was gained from the study: a…

78 FR 38943 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-28

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and..., Department of Commerce. SUMMARY: The Department of Commerce (the Department) has received information..., International Trade Administration, U.S. Department of Commerce, 14th Street and Constitution Avenue NW...

Scaffolding of long read assemblies using long range contact information

USDA-ARS?s Scientific Manuscript database

Long read technologies have made a revolution in de novo genome assembly by generating long contigs. Although the assembly contiguity has increased, it may not span a chromosome, resulting in an unfinished chromosome level assembly. To address this problem, we develop a scaffolding method that can b...

75 FR 42279 - Captive Nations Week, 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-21

... that deny their citizens freedom of religion, expression, and peaceful assembly; and between states... conviction of all who keep the light of freedom alive--remind us that human destiny will be what we make of it. The journey towards worldwide freedom and democracy sought in 1959 remains unfinished. Today, we...

77 FR 45587 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, from the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and... new shipper review (``NSR'') of the antidumping duty order on tapered roller bearings (``TRBs'') from... from Zhejiang Zhengda Bearing Co., Ltd. (``Zhejiang Zhengda''). Zhejiang Zhengda's request was made in...

The Unfinished Race

ERIC Educational Resources Information Center

Hawkins, B. Denise

2011-01-01

In this article, the author profiles Dolores E. Cross, who, during her more than 30-year academic career, has advocated for multicultural education, championed equal education access for all students, and blazed trails as the first African-American female president of Chicago State University and the first female president of Morris Brown College.…

Finishing of wood

Treesearch

R. Sam Williams

1999-01-01

The primary function of any wood finish (paint, varnish, and stain, for example) is to protect the wood surface, help maintain a certain appearance, and provide a cleanable surface. Although wood can be used both outdoors and indoors without finishing, unfinished wood surfaces exposed to the weather change color, are roughened by photodegradation and surface checking,...

Progress and Unfinished Business.

ERIC Educational Resources Information Center

Clark, Kenneth

1984-01-01

Analyzes some of the social and philosophical ideas underlying the Brown decision, and asserts that it has had a more positive effect on race relations in other areas of society than in the area of education. Argues that educators must now assume the role of communicating the importance of Brown to the public. (KH)

Unfinished Business: Addressing Unequal Opportunities in Education

ERIC Educational Resources Information Center

Cookson, Peter W., Jr.

2015-01-01

In October 2014, the US Department of Education's Office of Civil Rights issued a clarion call to school districts and states to review their policies and practices in order to ensure they are equitably providing educational resources to their schools. The quality of classroom instruction and the quality of the organizational systems supporting…

76 FR 41207 - Tapered Roller Bearings and Parts Thereof, Finished or Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

...) whether the respondent has autonomy from the government in making decisions regarding the selection of... respondent has autonomy from the government regarding the selection of management.\\28\\ \\28\\ See Sihe's SRA... published in the International Monetary Fund's International Financial Statistics.\\38\\ \\37\\ See Surrogate...

Unfinished Business: Student Perspectives on Disclosure of Mental Illness and Success in VET--Support Document

ERIC Educational Resources Information Center

Venville, Annie; Street, Annette

2012-01-01

Researchers from La Trobe University are investigating the factors affecting successful course completion for Vocational Education and Training (VET) students with a mental illness. The research aims to: (1) Increase individuals' understanding of the factors contributing to successful course completions by students with disclosed or non-disclosed…

The Unfinished Stories of Two First Nations Mothers

ERIC Educational Resources Information Center

Moayeri, Maryam; Smith, Jane

2010-01-01

This study is shaped by an underlying theoretical assumption that literacy is a cultural practice, shaped by and shaping social factors such as culture, gender, politics, and economics. As a result, this article focuses on the literacy practices of two mothers who participated in the study. Because of their Aboriginal ancestry and the historical…

Reading "Salt and Pepper": Social Practices, Unfinished Narratives, and Critical Interpretations

ERIC Educational Resources Information Center

Anderson, Diane Downer

2008-01-01

In "Reading "Salt and Pepper"" Anderson examines a story written by three third grade girls and their insights about that story as they re-read it during its production and retrospectively, eight years later. Using a frame for understanding children's writing as social practice, the children's interviews, showing their multiple and sometimes…

Unfinished Business: Writing as If You're Dying

ERIC Educational Resources Information Center

Ardoin, Nicole; Dillon, Justin

2010-01-01

Participants in the 10th International Seminar in Health and Environmental Education Research Symposium in Montebello, Quebec were presented with the challenge of considering the question, "If you could only write one book and one paper in your life from now on, what would the titles be?" The task was structured to stimulate thought…

Unfinished Business: The Immigration Reform and Control Act of 1986.

ERIC Educational Resources Information Center

Munoz, Cecilia

The intent of the Immigration Reform and Control Act (IRCA) of 1986 to eliminate the large exploitable subclass of undocumented immigrants living within the borders of the United States cannot be achieved through the methods chosen for its implementation. IRCA was designed to legalize the status of undocumented immigrants and to prevent more…

Richard Wright and the Agony over Integration

ERIC Educational Resources Information Center

Cassuto, Leonard

2008-01-01

Richard Wright's literary career begins with a lynching and ends with a serial murderer. "Big Boy Leaves Home," the 1936 story that leads off Wright's first book, "Uncle Tom's Children" (1938), renders the vicious mob-execution of a young black man falsely accused of rape. "A Father's Law," Wright's last novel, left unfinished at his unexpected…

76 FR 76143 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

..., the United Steel, Paper and Forestry, Rubber, Manufacturing, Energy, Allied Industrial and Service... from Blackstone OTR LLC and OTR Wheel Engineering, Inc. (collectively, ``Blackstone OTR''), the... Ruling on Blackstone OTR LLC and OTR Wheel Engineering, Inc.'s Wheel Hub Assemblies and TRBs,'' dated...

Still "Unfinished Education": Latino Students Forty Years after the Mexican American Education Study

ERIC Educational Resources Information Center

Madrigal-Gonzalez, Lizely

2012-01-01

The onus of this dissertation was to evaluate the educational conditions of Mexican American students forty years after the "Mexican American Education Study" published a six-volume study detailing the findings of the "Mexican American Education Study" (1970-1974). The "MAES" study focused on five southwest states…

77 FR 45588 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and... new shipper review (``NSR'') of the antidumping duty order on tapered roller bearings from the People... The notice announcing the antidumping duty order on tapered roller bearings from the PRC was published...

76 FR 6397 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and... on tapered roller bearings (``TRBs'') from the People's Republic of China (``PRC'') meets the... published in the Federal Register on June 15, 1987. See Antidumping Duty Order; Tapered Roller Bearings and...

76 FR 45777 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-601] Tapered Roller Bearings and... tapered roller bearings (``TRBs'') from the People's Republic of China (``PRC'') meets the statutory and... Register on June 15, 1987. See Antidumping Duty Order; Tapered Roller Bearings and Parts Thereof, Finished...

Unsettling Deficit Views of Students and their Communities

ERIC Educational Resources Information Center

Hattam, Robert; Prosser, Brenton

2008-01-01

In this paper we explore the possibilities for redesigning pedagogy in the middle years of schooling. We think that the middle schooling movement in Australia is unfinished because the pedagogical reforms promised have been patchy, not well researched and difficult to sustain. As well, middle schooling is a little exhausted because it has failed…

Is "Object-Centred Neglect" a Homogeneous Entity?

ERIC Educational Resources Information Center

Gainotti, Guido; Ciaraffa, Francesca

2013-01-01

The nature of object-centred (allocentric) neglect and the possibility of dissociating it from egocentric (subject-centred) forms of neglect are controversial. Originally, allocentric neglect was described by and in patients who reproduced all the elements of a multi-object scene, but left unfinished the left side of one or more of them. More…

Post-"Fisher": The Unfinished Research Agenda on Student Diversity in Higher Education

ERIC Educational Resources Information Center

Chang, Mitchell James

2013-01-01

In a symposium at the 2012 National Association of Diversity Officers in Higher Education annual conference, Claremont Graduate University Professor Daryl G. Smith, a pioneer in the study of diversity in postsecondary educational contexts, critiqued the disproportionate framing of diversity-related research around past, present, and future U.S.…

Equity and Excellence in Education Reform: An Unfinished Agenda.

ERIC Educational Resources Information Center

Sadker, Myra; Sadker, David

This paper argues that the recent wave of school reform literature has neglected females, thereby threatening to close already narrowing windows of opportunity for their advanced education beyond high school. A line-by-line content analysis of 138 articles on educational reform published in nine influential professional journals between 1983 and…

76 FR 76126 - Uncovered Innerspring Units from the People's Republic of China: Preliminary Results and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

... merchandise into the United States exported by Reztec. Consequently, we intend to rescind the review, in part... at 870; Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From Japan, and Tapered Roller Bearings, Four Inches or Less in Outside Diameter, and Components Thereof, From Japan; Preliminary...

The Philosophy of Science and Technology in China: Political and Ideological Influences

ERIC Educational Resources Information Center

Guo, Yuanlin

2014-01-01

In China, the philosophy of science and technology (PST) is derived from "Dialectics of Nature" (DN), which is based on Engels' unfinished book "Dialektik der Natur." DN as a political ideology provides political guidance for scientists and engineers. Therefore, since 1981, "Introduction to Dialectics of Nature" (IDN)…

The Unfinished Lincoln Memorial. Teaching with Documents.

ERIC Educational Resources Information Center

National Archives and Records Administration, Washington, DC.

Construction began on the memorial to Abraham Lincoln in 1915, fifty years after his assassination. Sculptor, Daniel Chester French, designed the statue to honor the 16th U.S. President. French had gained a national reputation with his earlier portrayal of "The Minute Man," a statue to honor those colonials who died at Lexington and…

Unfinished Business: Re-Positioning Gender on the Education Equity Agenda

ERIC Educational Resources Information Center

Gill, Judith; Tranter, Deborah

2014-01-01

The long-standing relationship between social disadvantage and poor educational outcomes continues to preoccupy educational policy-makers, with teachers at the front line of the ongoing struggle. Across the range of equity concerns, gender may be noted as either qualifying disadvantage or compounding it, but the meaning of gender as a simple…

Part One: Graduate Student Perspectives on the Development of Electronic Portfolios

ERIC Educational Resources Information Center

MacDonald, Laurie; Liu, Peilin; Lowell, Kay; Tsai, Howard; Lohr, Linda

2004-01-01

The word "portfolio" might bring to mind the artist's case bulging with sketches, samples and finished or unfinished works in no particular order. On the other hand, it might suggest the familiar collection of report cards, crayon drawings and dioramas that accumulate in schoolchildren's homes over the years. In an adult education setting,…

Artful Pedagogy: (En)Visioning the Unfinished Whole

ERIC Educational Resources Information Center

Shields, Sara Scott; Guyotte, Kelly W.; Weedo, Nicole

2016-01-01

The hum of florescent lights still drone quietly in the background just as they did in the high school art classrooms of the authors, only now they are teaching research methods and educational theory and practice in the academy, not sculpture, ceramics, drawing, or painting 1 Occasionally we refer to Sara's and Kelly's experiences as high school…

Unfinished Agendas: New and Continuing Gender Challenges in Higher Education

ERIC Educational Resources Information Center

Glazer-Raymo, Judith, Ed.

2008-01-01

This revealing volume examines the current role and status of women in higher education--and suggests a direction for the future. Judith Glazer-Raymo and other distinguished scholars and administrators assess the progress of women in academe using three lenses: the feminist agenda as a work in progress, growing internal and external challenges to…

78 FR 45505 - Certain Oil Country Tubular Goods from India, the Republic of Korea, the Republic of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... process based on the average import value of other ferrous waste and scrap using HTSUS subheadings 7204.41... products) or unfinished (including green tubes and limited service OCTG products), whether or not thread...; drill pipe; unattached couplings; and unattached thread protectors. The merchandise subject to the...

Voices for Women. 1980 Report of the President's Advisory Committee for Women.

ERIC Educational Resources Information Center

President's Advisory Committee for Women, Washington, DC.

This report presents the recommendations of the President's Advisory Committee for Women, a blueprint for action to complete the unfinished business of bringing equality and fair treatment to the women of the United States. The report is divided into six chapters. Chapter I describes the Committee's mandate, its tasks, and the process that led…

INTERIOR VIEW, WEST WALL OF NORTHWEST ATTIC CHAMBER. THIS SPACIOUS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR VIEW, WEST WALL OF NORTHWEST ATTIC CHAMBER. THIS SPACIOUS ROOM INCLUDED A ROOF MONITOR FOR LIGHT AND VENTILATION AND A FIREPLACE FOR HEAT. THE WALL OPENING AND DOOR ON EITHER SIDE OF THE FIREPLACE GIVE ONTO A LARGE UNFINISHED SPACE LOCATED OVER THE HOUSE’S WEST WING - The Woodlands, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

Unfinished Business with Feminist Thinking and Counselling and Guidance Practice

ERIC Educational Resources Information Center

Wright, Jeannie

2009-01-01

This article provides a personal view of the influence of feminist theories on counselling and guidance practice over a 30-year period. It is not intended to be a scoping review of the vast literature on feminist theory and practice in relation to the talking therapies. Based on the subjective experience of one researcher/practitioner, its…

16 CFR 303.33 - Country where textile fiber products are processed or manufactured.

Code of Federal Regulations, 2013 CFR

2013-01-01

... [Foreign Country]”. (ii) When the U.S. Customs Service requires an origin label on the unfinished product... manufacturer needs to consider the origin of only those materials that are covered under the Act and that are... species of product. Variant spellings which clearly indicate the English name of the country, such as...

16 CFR 303.33 - Country where textile fiber products are processed or manufactured.

Code of Federal Regulations, 2014 CFR

2014-01-01

... [Foreign Country]”. (ii) When the U.S. Customs Service requires an origin label on the unfinished product... manufacturer needs to consider the origin of only those materials that are covered under the Act and that are... species of product. Variant spellings which clearly indicate the English name of the country, such as...

16 CFR 300.25 - Country where wool products are processed or manufactured.

Code of Federal Regulations, 2014 CFR

2014-01-01

... an origin label on the unfinished product, the manufacturing processes as required in paragraph (a)(4... (a) (2), (3), or (4) of this section, a manufacturer needs to consider the origin of only those... of the name does not appear with such other words so as to refer to a kind of species of product...

16 CFR 300.25 - Country where wool products are processed or manufactured.

Code of Federal Regulations, 2013 CFR

2013-01-01

... an origin label on the unfinished product, the manufacturing processes as required in paragraph (a)(4... (a) (2), (3), or (4) of this section, a manufacturer needs to consider the origin of only those... of the name does not appear with such other words so as to refer to a kind of species of product...

16 CFR 300.25 - Country where wool products are processed or manufactured.

Code of Federal Regulations, 2012 CFR

2012-01-01

... an origin label on the unfinished product, the manufacturing processes as required in paragraph (a)(4... (a) (2), (3), or (4) of this section, a manufacturer needs to consider the origin of only those... of the name does not appear with such other words so as to refer to a kind of species of product...

16 CFR 303.33 - Country where textile fiber products are processed or manufactured.

Code of Federal Regulations, 2012 CFR

2012-01-01

... [Foreign Country]”. (ii) When the U.S. Customs Service requires an origin label on the unfinished product... manufacturer needs to consider the origin of only those materials that are covered under the Act and that are... species of product. Variant spellings which clearly indicate the English name of the country, such as...

Evolution of Apprenticeships and Traineeships in Australia: An Unfinished History. Occasional Paper

ERIC Educational Resources Information Center

Knight, Brian

2012-01-01

This paper traces the evolution of Australia's apprenticeship and traineeship system since permanent European settlement in 1788. The system was imported from Great Britain; it has evolved and diverged in some areas but retains many of the features of the British model. Most major changes have occurred in the last 25 years. The apprenticeship…

The Forest, Not the Tree(s): The Plight of the Generalist

ERIC Educational Resources Information Center

Reinsmith, William A.

2006-01-01

The great naturalist Edward O. Wilson's (1998) recent plea for the "consilience" of knowledge should strike a chord in the heart of every generalist. Invoking the unfinished agenda of the Enlightenment, Wilson has called for a rapprochement among the several branches of learning so that they can be viewed as interrelated and constituting a whole.…

Unfinished Business: The Uneven Past and Uncertain Future of One Historically Black University's Archives--A Personal Reflection

ERIC Educational Resources Information Center

Pevar, Susan Gunn

2011-01-01

This article presents a perspective on how the restructuring of a historically black university's library and resulting closure of its special collections and archives puts important records pertaining to African American history in jeopardy. This article traces the recent history of special collections and archives at the Lincoln University…

Short-Term Energy Outlook Model Documentation: Petroleum Products Supply Module

EIA Publications

2013-01-01

The Petroleum Products Supply Module of the Short-Term Energy Outlook (STEO) model provides forecasts of petroleum refinery inputs (crude oil, unfinished oils, pentanes plus, liquefied petroleum gas, motor gasoline blending components, and aviation gasoline blending components) and refinery outputs (motor gasoline, jet fuel, distillate fuel, residual fuel, liquefied petroleum gas, and other petroleum products).

The Unfinished Agenda: The Citizen's Policy Guide to Environmental Issues. A Task Force Report.

ERIC Educational Resources Information Center

Barney, Gerald O., Ed.

This book is the result of the Environmental Task Force, a group of 63 environmentalists who were asked to identify and describe the most critical environmental problems. It contains chapters on population, food and agriculture, the energy economy, natural resources, water and air pollution, hazards of toxic substances, land use and ecology,…

Discourses of Merit. The Hot Potato of Teacher Evaluation in Italy

ERIC Educational Resources Information Center

Barzanò, Giovanna; Grimaldi, Emiliano

2013-01-01

Italy is well known for its difficulty in introducing any educational evaluation system. This paper explores the dynamics which occurred in Italy in 2010-2011, within the context of the umpteenth national pilot of school and staff evaluation. Our research object is an unfinished project, observed in its development. We get close to the struggles…

New Labour and Higher Education

ERIC Educational Resources Information Center

Watson, David

2006-01-01

This paper is the second part of an edited version of a Keynote Presentation delivered at the 2006 AUA Annual Conference at Queen's University Belfast on 11 April. The first part was published in perspectives 10.3 in July 2006. In the Presentation Sir David commented on three areas of unfinished business with which New Labour has struggled; in the…

75 FR 844 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, from the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... pillow blocks) incorporating tapered rollers, with or without spindles, whether or not for automotive use... Department has made the following changes: We have revised the surrogate value for tube steel. See Issues and... Analysis Memorandum''). We have corrected the direct material calculation for bar and tube steel in our...

78 FR 3396 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... pillow blocks) incorporating tapered rollers, with or without spindles, whether or not for automotive use... JTEKT (Thailand) Co., Ltd. We valued CPZ/SKF's roller steel using Harmonized Tariff Schedule (``HTS... circular cross- section''), rather than HTS category 7227.90 (``Bars and rods of alloy steel (other than...

An Unfinished Experiment: Ambiguity and Conflict in the Implementation of Higher Skills Policy

ERIC Educational Resources Information Center

Hordern, Jim

2015-01-01

The higher skills policy of the UK New Labour Government emerged from the recommendations of the Leitch Review of Skills, and was implemented in England between 2007 and 2010. The policy aimed to encourage higher education (HE) institutions to engage with employers and employer representative bodies to design and deliver HE provision that…

Higher-Education Funds Are in Limbo as Congress Prepares to Head Home

ERIC Educational Resources Information Center

Field, Kelly

2008-01-01

This article reports that members of Congress were poised to leave Washington last week with some major higher-education accomplishments to campaign on and a slate of unfinished business important to colleges. Topping the higher-education to-do list for the next Congressional session is federal spending for the 2009 fiscal year, which began…

Promising Practices and Unfinished Business: Fostering Equity and Excellence for Black and Latino Males

ERIC Educational Resources Information Center

Tung, Rosann; Carlo, Vivian Dalila; Colón, Melissa; Del Razo, Jaime L.; Diamond, John B.; Raynor, Alethea Frazier; Graves, Daren; Kuttner, Paul J.; Miranda, Helena; St. Rose, Andresse

2015-01-01

Boston Public Schools (BPS) commissioned companion studies as part of its efforts to address achievement gaps for Black and Latino males. The first study revealed the increasing diversity of Black and Latino males and stark opportunity gaps throughout the system that contribute in large part to wide attainment gaps for these students. We…

Clinical and Pastoral Issues and Challenges in Working with the Dying and Their Families

ERIC Educational Resources Information Center

Rayburn, Carole A.

2008-01-01

How might counseling professionals interact with clients facing their own or a loved one's serious illness or death and help prepare them for this severe stress and loss? Counseling professionals are encouraged to do no harm, be sensitive to beliefs and traditions, use life stories, and help resolve unfinished business.

Unfinished Student Answer in PISA Mathematics Contextual Problem

ERIC Educational Resources Information Center

Lutfianto, Moch.; Zulkardi; Hartono, Yusuf

2013-01-01

Solving mathematics contextual problems is one way that can be used to enable students to have the skills needed to live in the 21st century. Completion contextual problem requires a series of steps in order to properly answer the questions that are asked. The purpose of this study was to determine the steps performed students in solving…

Unfinished Business in Clarifying Causal Measurement: Commentary on Bainter and Bollen

ERIC Educational Resources Information Center

Markus, Keith A.

2014-01-01

In a series of articles and comments, Kenneth Bollen and his collaborators have incrementally refined an account of structural equation models that (a) model a latent variable as the effect of several observed variables and (b) carry an interpretation of the observed variables as, in some sense, measures of the latent variable that they cause.…

"I Am Smart and I Am not Joking": Aiming High in the Middle Years of Schooling

ERIC Educational Resources Information Center

Prosser, Brenton; McCallum, Faye; Milroy, Philippa; Comber, Barbara; Nixon, Helen

2008-01-01

In this paper, we draw on accounts from students to inform a Middle Schooling movement that has been variously described as "arrested", "unfinished" and "exhausted". We propose that if the Middle Schooling movement is to understand the changing worlds of students and develop new approaches in the middle years of…

Narrating Unfinished Business: Adult Learners Using Credit Transfer to Re-Engage with Higher Education

ERIC Educational Resources Information Center

Pegg, Ann; Di Paolo, Terry

2013-01-01

This paper seeks to advance our understanding of the credit transfer phenomenon in the UK, specifically how students draw on a credit as a form of institutional cultural capital. Drawing on interviews with 26 part-time mature learners, this paper examines the progressive and retrospective orientations to study that surfaced in students' accounts…

75 FR 41148 - Tapered Roller Bearings and Parts Thereof, Finished or Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

.... Initiation of Scope Determination of New Torch's Wheel Hub Assemblies From October 30, 2009, through May 5, 2010, in various supplemental questionnaires, New Torch stated that it produced and sold wheel hub... on TRBs. On June 15, 2010, the Department initiated two scope inquiries on wheel hub assemblies...

77 FR 52682 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... OTR Wheel Engineering, Inc.'s Wheel Hub Assemblies and TRBs,'' dated February 7, 2011 (finding Blackstone OTR LLC and OTR Wheel Engineering, Inc.'s wheel hub assemblies are within the scope of the order... Trend Engineering Ltd.'s Wheel Hub Assemblies,'' dated April 18, 2011 (finding New Trend Engineering...

76 FR 3086 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished, From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

... Administrative Review of the Antidumping Duty Order, 75 FR 41148 (July 15, 2010) (``Preliminary Results''). The period of review (``POR'') is June 1, 2008, through May 31, 2009. This review covers three respondents: (1) The majority Spungen family-owned joint-venture Peer Bearing Company Ltd.--Changshan (``PBCD/CPZ...

Leveraging Conflict to Achieve Advances in Civil Rights: Community Leadership--An Unfinished Work for Educators

ERIC Educational Resources Information Center

Canfield-Davis, Kathy; Gardiner, Mary E.

2017-01-01

The purpose of this research was to identify community leadership praxis of an activist for Lesbian, Gay, Bi-sexual and Transgender civil rights in community housing, employment and public accommodations. The qualitative single-case study included data from city council meetings, interviews with Tony Stewart, the community leader/activist, other…

The "Functional" and "Social" Uses of Literacy.

ERIC Educational Resources Information Center

Duffey, Joseph

The task of providing the tools of basic literacy for all citizens is still unfinished in the United States, as well as on an international scale. No longer can the developed and underdeveloped worlds relate as mentor and learner; the United States has much to learn from the great work in literacy and basic education performed in lesser developed…

Primary Education in Latin America: The Unfinished Agenda. Sustainable Development Department Technical Papers Series.

ERIC Educational Resources Information Center

Wolff, Laurence; Schiefelbein, Ernesto; Schiefelbein, Paulina

This paper assesses progress made in elementary education in Latin America from 1990-2000. Besides examining completion rates, it looks at four critical indicators: the extent to which repetition rates have declined over the decade; the extent of timely access and on-time ages of elementary school students; the level or elementary school students'…

Unfinished Business: Student Perspectives on Disclosure of Mental Illness and Success in VET. Research Report

ERIC Educational Resources Information Center

Venville, Annie; Street, Annette

2012-01-01

Of all the different types of disability, mental illness can be particularly disruptive to education and training outcomes. In this report, the authors explore the factors contributing to successful course completion for students with a mental illness. The authors especially focus on the role of disclosure and the reasons why students choose to…

Basic Education in China's Rural Areas: A Legal Obligation or an Individual Choice?

ERIC Educational Resources Information Center

Liu, Fengshu

2004-01-01

This study takes a close look at the whole cycle of the 9-yr compulsory education in two communities in north China. It reveals that although there are nearly 100% enrollment and completion rates at the primary level, dropouts constitute a serious problem at the secondary level, thus rendering the 9-yr compulsory schooling an unfinished cycle.…

Race as a Social Construct: The Impact on Education

ERIC Educational Resources Information Center

Dorris, Ronald

2009-01-01

Today as part of the network of globalization, the United States is trailing through the 21st century on the note of an unfinished past. As a legally segregated entity of United States citizenry from 1896-1954, people of African descent largely would be on their own when it came to creating a positive self-image. Those who genuinely sought to…

Agriculture, Rural Development, Food and Drug Administration, and Related Agencies Appropriations Act, 2015

THOMAS, 113th Congress

Rep. Aderholt, Robert B. [R-AL-4

2014-06-04

House - 06/11/2014 Committee of the Whole House on the state of the Union rises leaving H.R. 4800 as unfinished business. (All Actions) Notes: For further action, see H.R.83, which became Public Law 113-235 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Department of the Interior, Environment, and Related Agencies Appropriations Act, 2012

THOMAS, 112th Congress

Rep. Simpson, Michael K. [R-ID-2

2011-07-19

House - 07/28/2011 Committee of the Whole House on the state of the Union rises leaving H.R. 2584 as unfinished business. (All Actions) Notes: For further action, see H.R.2055, which became Public Law 112-74 on 12/23/2011. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Transportation, Housing and Urban Development, and Related Agencies Appropriations Act, 2014

THOMAS, 113th Congress

Rep. Latham, Tom [R-IA-3

2013-07-02

House - 07/30/2013 Committee of the Whole House on the state of the Union rises leaving H.R. 2610 as unfinished business. (All Actions) Notes: For further action, see H.R.3547, which became Public Law 113-76 on 1/17/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

An Unfinished Jigsaw: The 16+ Curriculum in the 1990s.

ERIC Educational Resources Information Center

Kershaw, Noel

Education reform in Great Britain during the last 15 years has been piecemeal, and all the pieces are not yet in place for broad and balanced post-16 education. The last 10 years of debate have achieved much common ground among the goals perceived by government, industry, and education. Three major ways of looking at the post-16 curriculum have…

77 FR 65668 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-30

...) incorporating tapered rollers, with or without spindles, whether or not for automotive use. These products are... steel scrap by-product. We intended to grant an offset for this byproduct but made a clerical error in the Preliminary Results by not granting an offset for the steel scrap but rather, adding it to direct...

Promising Practices and Unfinished Business: Fostering Equity and Excellence for Black and Latino Males. Executive Summary

ERIC Educational Resources Information Center

Tung, Rosann; Carlo, Vivian Dalila; Colón, Melissa; Del Razo, Jaime L.; Diamond, John B.; Raynor, Alethea Frazier; Graves, Daren; Kuttner, Paul J.; Miranda, Helena; St. Rose, Andresse

2015-01-01

Boston Public Schools (BPS) commissioned companion studies as part of its efforts to address achievement gaps for Black and Latino males. The first study revealed the increasing diversity of Black and Latino males and stark opportunity gaps throughout the system that contribute in large part to wide attainment gaps for these students. We…

Methodological Appendix of Research Methods Employed in the Mexican American Education Study.

ERIC Educational Resources Information Center

Commission on Civil Rights, Washington, DC.

The U.S. Commission on Civil Rights released Mexican American Education Study findings in a series of documents: (1) "The Ethnic Isolation of Mexican Americans in the Public Schools of the Southwest" (ED 052 849), "The Unfinished Education" (ED 056 821), and "The Excluded Student" (ED 062 069). The research methods employed in the study are…

To Learn and Earn: Arizona's Unfinished Business in Human Capital

ERIC Educational Resources Information Center

Welch, Nancy

2009-01-01

Raising Arizona was the challenge of the 20th century. Sustaining Arizona is now the challenge of the 21st. A crucial part of that task is not just understanding today's knowledge economy, but mastering it. Ray and Charles Eames, the creative geniuses behind many iconic 20th century designs, debuted their film "Powers of 10" in 1977. In…

Unfinished Agenda: Child Care for Low-Income Families Since 1996. Implications for Federal and State Policy. [Report and] Policy Brief.

ERIC Educational Resources Information Center

Mezey, Jennifer; Greenberg, Mark H.; Schumacher, Rachel; Lombardi, Joan; Hutchins, John

This report and policy brief synthesizes findings from five reports on the experiences of low-income parents, child care providers, and state child care systems in Illinois, Iowa, Maine, Texas, and Washington. In recent years, there has been increased national funding for child care but deteriorating economic conditions that could jeopardize…

77 FR 32522 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-01

... is renumbered as 8708.99.8180; see Id. Bona Fides Sale Analysis For this review, consistent with the... POR. In evaluating whether or not a sale in a new shipper review is commercially reasonable, and... Shipper Review, 67 FR 11283 (March 13, 2002)). The Department preliminarily finds that the sales of...

Politics and the life sciences: an unfinished revolution.

PubMed

Johnson, Gary R

2011-01-01

Politics and the life sciences--also referred to as biopolitics--is a field of study that seeks to advance knowledge of politics and promote better policymaking through multidisciplinary analysis that draws on the life sciences. While the intellectual origins of the field may be traced at least into the 1960s, a broadly organized movement appeared only with the founding of the Association for Politics and the Life Sciences (APLS) in 1980 and the establishment of its journal, Politics and the Life Sciences ( PLS ), in 1982. This essay--contributed by a past journal editor and association executive director--concludes a celebration of the association's thirtieth anniversary. It reviews the founding of the field and the association, as well as the contributions of the founders. It also discusses the nature of the empirical work that will advance the field, makes recommendations regarding the identity and future of the association, and assesses the status of the revolution of which the association is a part. It argues that there is progress to celebrate, but that this revolution--the last of three great scientific revolutions--is still in its early stages. The revolution is well-started, but remains unfinished.

[The unfinished agenda for child survival: what role for the integrated management of childhood illness?].

PubMed

Lambrechts, T; Gamatié, Y; Aboubaker, S

2005-01-01

The endorsement by the United Nations General Assembly of the Millennium Development Goals (MDG) and the growing acknowledgment by the international community that child survival is an unfinished agenda created a new momentum for rapid scaling up of effective child health interventions. In this review, the authors discuss the environment in which child health programs are being implemented and the potential role of the integrated management of childhood illness (IMCI) strategy in country efforts to achieve the MDGs. The discussion is based on the conclusions of a multi-country analytic review of the IMCI strategy conducted jointly by DFID, UNICEF, USAID, and WHO as well as the results of another multi-country evaluation coordinated by the WHO on IMCI costs, effectiveness, and impact. The article concludes on the need to increase child health investments and on the potential importance of IMCI in improving child survival. However, the MDGs may not be reached if IMCI is not implemented in conjunction with other strategies to reduce mortality during the first days of life and to strengthen the health system. The authors also stress the need to increase research on mechanisms to scale up delivery of existing public health interventions.

Students' Constitutional Right to a Sound Basic Education: New York State's Unfinished Agenda. Part 4. Ensuring Resource Accountability

ERIC Educational Resources Information Center

Wolff, Jessica R.; Rebell, Michael A.; Rogers, Joseph R., Jr.

2016-01-01

This is the fourth in a series of reports that are the culmination of two years of research by the Campaign for Educational Equity, a policy and research center at Teachers College, Columbia University, and significant input from the Safeguarding Sound Basic Education Task Force, a statewide group made up of representatives from New York's leading…

The Unfinished Nature of Rights-Informed HIV- and AIDS-Related Education: An Analysis of Three School-Based Initiatives

ERIC Educational Resources Information Center

Miedema, Esther; Maxwell, Claire; Aggleton, Peter

2015-01-01

Over the past 25 years, there has been growing investment in concepts of rights in the areas of HIV prevention, care and treatment, including HIV- and AIDS-related education delivered in schools. Despite this increasing commitment to the notion of rights, few efforts appear to have been made to understand the varying conceptions of rights that…

An Unfinished Job? The Effect of Subject Choice and Family Formation Processes on Labour Market Outcomes of Young Men and Women

ERIC Educational Resources Information Center

Duquet, Nils; Glorieux, Ignace; Laurijssen, Ilse; Van Dorsselaer, Yolis

2010-01-01

Despite their generally higher educational attainment, young women are characterised by lower labour market positions than men in Belgium. Using regression and decomposition analyses on data from the longitudinal SONAR survey on the transition from school to work, we examine to what extent subject choice and processes of family formation can…

Unfinished Business: Continued Investment in Child Care and Early Education Is Critical to Business and America's Future. Executive Summary

ERIC Educational Resources Information Center

Committee for Economic Development, 2012

2012-01-01

Business leaders have an acute understanding of the importance of a well-educated workforce to support a strong economy, keep America competitive globally, and ensure a vibrant democracy. Right now 20 percent of the American labor force is functionally illiterate or innumerate. High-quality child care and early education builds a strong foundation…

Unfinished Business: Continued Investment in Child Care and Early Education is Critical to Business and America's Future

ERIC Educational Resources Information Center

Committee for Economic Development, 2012

2012-01-01

The Committee for Economic Development (CED) has a decades-old commitment to quality early childhood education. CED Trustees have always been in the forefront of the effort to promote early learning and development for all children. Over recent years, the case for investment in the early years of childhood has become stronger and more urgent.…

Students' Constitutional Right to a Sound Basic Education: New York State's Unfinished Agenda. Part 2. Filling the Regulatory Gaps

ERIC Educational Resources Information Center

Rebell, Michael A.; Wolff, Jessica R.; Rogers, Joseph R., Jr.; Saleh, Matthew

2016-01-01

This is the second in a series of reports that are the culmination of two years of research by the Campaign for Educational Equity, a policy and research center at Teachers College, Columbia University, and significant input from the Safeguarding Sound Basic Education Task Force, a statewide group made up of representatives from New York's leading…

India-U.S. Relations

DTIC Science & Technology

2007-02-13

U.S. Relations Summary Long considered a “strategic backwater”from Washington’s perspective, South Asia has emerged in the 21st century as...South Asia focuses on ongoing tensions between India and Pakistan, a problem rooted in unfinished business from the 1947 Partition, competing claims to...weapons and ballistic missiles in South Asia . Both India and Pakistan have resisted external pressure to sign the major nonproliferation treaties

India-U.S. Relations

DTIC Science & Technology

2007-01-03

Summary Long considered a “strategic backwater”from Washington’s perspective, South Asia has emerged in the 21st century as increasingly vital to... Asia focuses on ongoing tensions between India and Pakistan, a problem rooted in unfinished business from the 1947 Partition, competing claims to the...and ballistic missiles in South Asia . Both India and Pakistan have resisted external pressure to sign the major nonproliferation treaties. In 1998

Indian-U.S. Relations

DTIC Science & Technology

2007-01-03

U.S. Relations Summary Long considered a “strategic backwater”from Washington’s perspective, South Asia has emerged in the 21st century as increasingly...in South Asia focuses on ongoing tensions between India and Pakistan, a problem rooted in unfinished business from the 1947 Partition, competing...nuclear weapons and ballistic missiles in South Asia . Both India and Pakistan have resisted external pressure to sign the major nonproliferation

78 FR 12035 - Tapered Roller Bearings and Parts Thereof, Finished and Unfinished From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... investigated or reviewed PRC and non-PRC exporters not listed above that have separate rates, the cash deposit... cash deposit rate will be the PRC- wide rate of 92.84 percent; and (4) for all non-PRC exporters of... expenses twice for certain sales. We unintentionally failed to offset CPZ/SKF's freight expenses with its...

A Numerical Evaluation on the Viability of Heap Thermophilic Bioleaching of Chalcopyrite

NASA Astrophysics Data System (ADS)

Vilcaez, J.; Suto, K.; Inoue, C.

2007-03-01

The present numerical evaluation explores into the interactions among the many variables governing the mass and heat transport processes that take place in a heap thermophilic bioleaching system. The necessity of using mesophiles together with thermophiles is proved by tracing the activity of both microorganisms individually at each point throughout the heap. The role of key variables such as the fraction of FeS2 per CuFeS2 leached was quantified and its importance highlighted. In this evaluation, the heat transfer process plays the main role because of the heat accumulation required to maintain the heap temperature within the range of 60 °C to 80 °C where thermophilic microorganisms are capable of completing the unfinished dissolution of copper started by mesophilic microorganisms at 30 °C. The evaluation was done taking into consideration: biological activity as function of the temperature in the heap, heat loss due to conduction and advection from the top and bottom of the heap, and mass transfer between the gas and liquid phases as a function of temperature. The exothermic nature of the leaching reactions of CuFeS2 and FeS2 makes the system auto-thermal.

Genome-wide analysis of the WRKY transcription factors in aegilops tauschii.

PubMed

Ma, Jianhui; Zhang, Daijing; Shao, Yun; Liu, Pei; Jiang, Lina; Li, Chunxi

2014-01-01

The WRKY transcription factors (TFs) play important roles in responding to abiotic and biotic stress in plants. However, due to its unfinished genome sequencing, relatively few WRKY TFs with full-length coding sequences (CDSs) have been identified in wheat. Instead, the Aegilops tauschii genome, which is the D-genome progenitor of the hexaploid wheat genome, provides important resources for the discovery of new genes. In this study, we performed a bioinformatics analysis to identify WRKY TFs with full-length CDSs from the A. tauschii genome. A detailed evolutionary analysis for all these TFs was conducted, and quantitative real-time PCR was carried out to investigate the expression patterns of the abiotic stress-related WRKY TFs under different abiotic stress conditions in A. tauschii seedlings. A total of 93 WRKY TFs were identified from A. tauschii, and 79 of them were found to be newly discovered genes compared with wheat. Gene phylogeny, gene structure and chromosome location of the 93 WRKY TFs were fully analyzed. These studies provide a global view of the WRKY TFs from A. tauschii and a firm foundation for further investigations in both A. tauschii and wheat. © 2015 S. Karger AG, Basel.

Students' Constitutional Right to a Sound Basic Education: New York State's Unfinished Agenda. Part 3. Utilizing a Constitutional Cost Methodology

ERIC Educational Resources Information Center

Rebell, Michael A.; Wolff, Jessica R.

2016-01-01

This is the third in a series of reports that are the culmination of two years of research by the Campaign for Educational Equity, a policy and research center at Teachers College, Columbia University, and significant input from the Safeguarding Sound Basic Education Task Force, a statewide group made up of representatives from New York's leading…

The Longitudinal Prevalence of Unfinished Nursing Care at the US Army Burn Center

DTIC Science & Technology

2018-01-02

vocational nurses completed a 50- item, paper survey . Administrative data related to nursing staff supply and working conditions also were collected monthly...from local nurse leaders. Sample: In total, 599 surveys were handed out to 118 nurses; 269 useable surveys were returned (overall response rate... survey . Administrative data related to nursing staff supply and working conditions also were collected monthly from local nurse leaders. Sample

Unfinished Business: The Sons of Iraq and Political Reconciliation

DTIC Science & Technology

2010-03-25

out in the National Strategy for Victory in Iraq. 3 of sectarian cleansing in Baghdad, population centric tactics by CF, and increased... cleansed neighborhoods of one sect or the other as the two sides vied for power. Shia families in Sunni dominated areas packed up as many belongings...and Selected Neighborhoods18 8 The Shia controlled government reinforced JAM’s ethnic cleansing operations through a denial of essential

Translations on Eastern Europe, Political, Sociological and Military Affairs, Number 1577.

DTIC Science & Technology

1978-08-18

4 to 5 percent annually, and should increase the utilization of production funds by 10 percent. Unfinished production should be...whole organization of bourgeois society today." 4 In conformity with social existence itself, the workers class has become the centerpiece of the new ...higher level, of the new , socialist features among all workers. Precisely that way the working class always again lives up to its new and

Students' Constitutional Right to a Sound Basic Education: New York State's Unfinished Agenda. Part 1. A Roadmap to Constitutional Compliance Ten Years after "CFE v. State"

ERIC Educational Resources Information Center

Rebell, Michael A.; Wolff, Jessica R.

2016-01-01

Ten years have passed since New York's highest court ruled in the landmark school-funding and educational-rights case, "Campaign for Fiscal Equity (CFE) v. State of New York," that the state was violating students' constitutional right to the "opportunity for a sound basic education" and ordered significant reforms of the…

The Unfinished Business of Welfare Reform: Improving Prospects for Poor Children and Youth. Perspectives from Research. A Special Child Trends Report.

ERIC Educational Resources Information Center

Scarupa, Harriet J., Ed.

As federal and state officials consider the reauthorization of the block grants at the center of the 1996 federal welfare reform law, it is critical that they use findings from research regarding the impact of welfare reform to guide their decisions. This special report examines the impact of welfare reform on children and youth, drawing on…

India-U.S. Relations

DTIC Science & Technology

2006-11-09

Asia focuses on ongoing tensions between India and Pakistan, a problem rooted in unfinished business from the 1947 Partition and competing claims to the...between India and Pakistan. The United States also seeks to curtail the proliferation of nuclear weapons and ballistic missiles in South Asia . Both...qdr/fulltext/nss2002.pdf] and [http://www.comw.org/qdr/fulltext/nss2006.pdf]. President Bill Clinton’s March 2000 visit to South Asia seemed a major

"The Effort of Reason, and the Adventure of Beauty": The Aesthetic Rhetoric of Randolph Bourne

ERIC Educational Resources Information Center

Crick, Nathan; Engels, Jeremy

2012-01-01

We are still coming to terms with the legacy of Randolph Bourne. Although he died at the age of 32 just as the United States was cheerfully entering the First World War under the banner of "democracy," the words he penned in an unfinished essay still resonate in the American social conscience: "War is the Health of the State." This maxim, once…

East Europe Report, Economic and Industrial Affairs, No. 2380.

DTIC Science & Technology

1983-03-18

12, 1982) 29 Sugar Beet Growing Methods Examined (Jana Kastankova, et al.; EKONOMIKA POLNOHOSPODARSTVA, No 1, 1983) 34 HUNGARY Structural...production of genuine seeds. A sad situation develops when we see uneven crops in the testing sectors next to seed- growing areas. P. Petkov: In...to unfinished strains this is due to weaknesses in strain support, crop growing technologies, and others. Major weaknesses are allowed in the

East Europe Report, Economic and Industrial Affairs

DTIC Science & Technology

1984-09-20

most isignificant collaborating enterpirse was VUKOV Presov, where a joint Czechoslovak-Soviet design and construction center was established. Within...SP. Slovenia on 1 20. ^ » Sorbia without - j n>nn T-.O -in CIR Hrnatia on 25,000 na, in oAr vojvuuxiici SAP territories on 7,000 ha, in bK uroauj-d... J /Text/ There is still not sufficient insight into the negative consequences of increased export of raw materials and unfinished goods in

The Explicit and Implicit Qualities of Alternative Fuels: Issues to Consider for Their Use in Marine Diesel Engines

DTIC Science & Technology

2008-09-30

problematic. However, such unfinished fuels are unlikely to be commercially available. Finishing those fuels by hydrotreating to remove excess...comparison, biodiesel does not meet several explicit properties because of higher acidity , viscosity, instability, pour point, and metals and ash content...would improve the remaining limiting properties of F-T and biodiesel fuels. Lubricity additives should remove the potential liability of the low

The Unfinished Business, Twenty Years Later. A Report Submitted to The U.S. Commission on Civil Rights by its Fifty-One State Advisory Committees.

ERIC Educational Resources Information Center

Commission on Civil Rights, Washington, DC.

This reference work details state by state progress in civil rights since the enactment of the Civil Rights Act of 1957. The 51 reports (50 states plus the District of Columbia) reiterate the major problems of the past two decades including education and employment. Other civil rights issues identified by the State advisory committees were:…

Procedimientos Comunes de Operacion Para Juntas Responsabilidades y Derechos del Presidente, Vice Presidente, Secretaria, y Miembros (Standard Procedures of Operation for Meetings, Rights, and Responsibilities of the President, Vice President, Secretary, and Members).

ERIC Educational Resources Information Center

Gonzalez, Ramon

Of use to Parent Advisory Committees, this Spanish-English handout briefly describes the standard procedures used to conduct meetings and outlines the duties of committee officers and members. The pamphlet describes the standard order of business at a meeting, including calling a meeting to order, roll call, minutes, reports, unfinished and new…

End-of-life issues: difficult decisions and dealing with grief.

PubMed

Loomis, Beth

2009-06-01

People face many challenging psychosocial and spiritual issues as they approach the end of their lives, and caregivers need advice on how to help them. Choosing among treatment options, handling grief, addressing unfinished business, and coping with loss of self-sufficiency are difficult for the dying person, and caregivers must deal with surrogate decision making, raw emotions in the patient and in family members, and the caregivers' own grief. Listening and coping skills are discussed.

Paleontology at the "high table"? Popularization and disciplinary status in recent paleontology.

PubMed

Sepkoski, David

2014-03-01

This paper examines the way in which paleontologists used "popular books" to call for a broader "expanded synthesis" of evolutionary biology. Beginning in the 1970s, a group of influential paleontologists, including Stephen Jay Gould, Niles Eldredge, David Raup, Steven Stanley, and others, aggressively promoted a new theoretical, evolutionary approach to the fossil record as an important revision of the existing synthetic view of Darwinism. This work had a transformative effect within the discipline of paleontology. However, by the 1980s, paleontologists began making their case to a wider audience, both within evolutionary biology, and to the general public. Many of their books-for example, Eldredge's provocatively-titled Unfinished Synthesis-explicitly argued that the received synthetic view of Darwinian evolution was incomplete, and that paleontological contributions such as punctuated equilibria, the hierarchical model of macroevolution, and the study of mass extinction dynamics offered a substantial corrective to evolutionary theory. This paper argues that books-far from being "mere popularizations" of scientific ideas-played an important role in disciplinary debates surrounding evolutionary theory during the 1980s, and in particular that paleontologists like Gould and Eldredge self-consciously adopted the book format because of the importance of that genre in the history of evolutionary biology. Copyright © 2013 Elsevier Ltd. All rights reserved.

China’s Banking Reform Strategies and Its Effects on the Modernization Efforts of the People’s Liberation Army

DTIC Science & Technology

2007-12-01

through the sale of ownership shares to individual investors or by the licensing of new private institutions and expanding the role of foreign financial ... institutions , market forces will have a greater input in focusing capital resources.22 Nicholas Lardy elegantly captures the dilemma for Beijing’s...Unfinished Revolution, Washington D.C.: Brookings Institution Press, 1998, 220. 22 John Langlois, Jr., “The WTO and China’s Financial System” The China

28. ROOM 211, VIEW TO THE SOUTHEAST. THE LONG NARROW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. ROOM 211, VIEW TO THE SOUTHEAST. THE LONG NARROW SPACE HAS EXPOSED TRUSSWORK IN UNPAINTED WOOD AS DID ALL UPSTAIRS ROOMS IN THEIR ORIGINAL CONDITION. CLERESTORY WINDOWS ARE INTERSPERSED WITH VENTS ALONG BOTH LONG SIDES OF THE ROOM. WALLS HAVE WIDE WOOD PANELING THAT IS PAINTED, FLOORS ARE WOOD. DOORWAY IN SOUTHWEST WALL LEADS TO UNFINISHED ATTIC SPACE. - Presidio of San Francisco, Cavalry Stables, Cowles Street, between Lincoln Boulevard & McDowell Street, San Francisco, San Francisco County, CA

Strategies of Adaptation: A Soviet Enterprise Under Perestroika and Privatization

DTIC Science & Technology

1991-06-01

Rozhkov. "The Beginnings of Producer Goods Auctions in the USSR." A. Bardhan and Gregory Grossman. "A Producer Goods Auction in the USSR." 23. Kimberly...similar sort of investment hunger. Leggett (1983, p . 142) reports that, in 1980, the amount of unfinished construction was equivalent to about six percent...of the value of the total capital stock in the economy, and to almost eighty percent of total fixed capital investment. According to Aslund (1989, p

The Durability of Cultural Influences: How American Foreign Policy Reinforced Historical Biases in El Salvador

DTIC Science & Technology

2008-05-01

America Since 1920,” Journal of Latin American Studies, 1983: 276. 11 Kevin Sullivan, “El Salvador: On Unfinished Road to Reform; Despite Being...different than those of President Carter. In fact, a substantial part of his party plank cited key differences between his and the ex-president’s Central...true: Castro himself was influential with FMLN leadership ; in fact, the FMLN formed at his urging.42 The full extent to which Castro, the Soviets or

The United States, Russia, Europe, and Security: How to Address the Unfinished Business of the Post-Cold War Era

DTIC Science & Technology

2012-04-01

offered transparency and force limitations through clear rules of the game, enabling former enemies to keep suspicions in check. It guarantees...will have to change. Of course, it will change should oil prices drop to the point of getting Russia on its knees . Beyond such a scenario, there will...and addressing security challenges in and around Europe. Today’s declaratory policy hardly matches the facts on the ground, and the rules of the

Book Review - Panofsky on Physics, Politics, and Peace: Pief Remembers

NASA Astrophysics Data System (ADS)

Loew, Gregory

The following sections are included: * Introduction: Genesis of the Book * Nature and Nurture: Pief's Early Life * This Review * High School in Hamburg; University at Princeton and Caltech * Pief and the Bomb * Accelerators and Physics at UCRL * Events Leading up to the Loyalty Oath * Stanford, the Microwave Lab and HEPL * The Rise of SLAC * Building SLAC * Physics Research at SLAC in the First Ten Years * Other Accelerator Activities under Pief * Science Advising and International Science * Arms Control (1981-2007): The Unfinished Business

[Social control and information democratization: a process under construction].

PubMed

Assis, Marluce Maria Araújo; Villa, Tereza Cristina Scatena

2003-01-01

This work aims at a critical reflection on social control as a legal-institutional achievement and its legitimacy conditions, pointing out strategies for information democratization in the local health system. The text was developed according to three thematic units: the first discusses social participation as a legal-institutional achievement; the second analyzes the essential conditions for legitimacy and the third presents information as a fundamental element for management and social control as an unfinished process that is still under construction.

Newborn health: everybody's business.

PubMed

Darmstadt, Gary L; Munar, Wolfgang; Henry, Sarah K

2014-01-01

Despite advances in issue-attention and in evidence of what works to save newborn lives (e.g., kangaroo mother care, antenatal corticosteroids, immediate and exclusive breastfeeding), we are still falling short on impact. To advance the unfinished newborn survival agenda, newborns must become an integral priority in developing countries where the burden of neonatal mortality is highest. Interventions must be adapted to local contexts and cultures and integrated into packages along the continuum of care delivered through the primary health-care systems that countries have at their disposal.

Scenes from an Unfinished War: Low-Intensity Conflict in Korea, 1966-1969 (Leavenworth Papers, Number 19)

DTIC Science & Technology

1991-07-01

1966, he hosted the Asian Pacific Council (Taiwan, Japan, Malaysia , the Philip- pines, South Vietnam, Thailand, Australia, and Laos) in Seoul. It...fingered worked as contract employees of U.S. Eighth Army, one of the cells having been in place since 1961.55 But by August, they were gone. The year...firmly in control.8 Like the strength of the Samsung and Hyundai corporations, the overbearing might of the soldiery in Seoul is also a legacy of the

Indoor mold spore exposure: characteristics of 127 homes in southern California with endogenous mold problems.

PubMed

Gallup, J; Kozak, P; Cummins, L; Gillman, S

1987-01-01

We are constantly being exposed to molds in our environment. Indoor mold problems occur after prolonged or chronic water damage to a variety of organic materials such as unfinished wood, jutebacked carpeting, wallpaper, books, cardboard, leather, cork, paper, wallboard, and wicker baskets. Mechanisms for spore dispersal (such as air currents or foot traffic on carpets) must also be present. The presence of these organic materials and dispersal mechanisms leads to significant increases in indoor spore levels.

Unfinished Business: A Framework for Peace in the Great Lakes (Africa Security Brief, Number 21, July 2012)

DTIC Science & Technology

2012-07-01

where they are levied with fees and re-exported, often by lo- cal businesses. This has become a significant source of economic activity and growth ...Policies for Growth with a Focus on Household Enterprises, Rwanda Economic Update 2 nd Edition, (Washington, DC: World Bank, November 2011), 3. 9 Ivan...extended instability has also led to a collapse of basic social services and economic activ- ity in parts of the Democratic Republic of the Congo

A Factor Linking Floral Organ Identity and Growth Revealed by Characterization of the Tomato Mutant unfinished flower development (ufd).

PubMed

Poyatos-Pertíñez, Sandra; Quinet, Muriel; Ortíz-Atienza, Ana; Yuste-Lisbona, Fernando J; Pons, Clara; Giménez, Estela; Angosto, Trinidad; Granell, Antonio; Capel, Juan; Lozano, Rafael

2016-01-01

Floral organogenesis requires coordinated interactions between genes specifying floral organ identity and those regulating growth and size of developing floral organs. With the aim to isolate regulatory genes linking both developmental processes (i.e., floral organ identity and growth) in the tomato model species, a novel mutant altered in the formation of floral organs was further characterized. Under normal growth conditions, floral organ primordia of mutant plants were correctly initiated, however, they were unable to complete their development impeding the formation of mature and fertile flowers. Thus, the growth of floral buds was blocked at an early stage of development; therefore, we named this mutant as unfinished flower development ( ufd ). Genetic analysis performed in a segregating population of 543 plants showed that the abnormal phenotype was controlled by a single recessive mutation. Global gene expression analysis confirmed that several MADS-box genes regulating floral identity as well as other genes participating in cell division and different hormonal pathways were affected in their expression patterns in ufd mutant plants. Moreover, ufd mutant inflorescences showed higher hormone contents, particularly ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) and strigol compared to wild type. Such results indicate that UFD may have a key function as positive regulator of the development of floral primordia once they have been initiated in the four floral whorls. This function should be performed by affecting the expression of floral organ identity and growth genes, together with hormonal signaling pathways.

Challenges to development in India: The Role of Education

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Rajan

This talk is based on my experiences with issues in development and education in India. I will describe three unfinished journeys: (i) How HIV/AIDS education and awareness lead to a program of "students as agents of change" through the creation of multimedia presentations on societal issues; (ii) how teaching health to village outreach workers lead to an understanding of adolescent migration from villages to towns in search for jobs and the spectre of alcoholism; and(iii) how teaching health to sex workers in Kolkata lead to an understanding of their closed world.

Challenges to Development in India: The Role of Education

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Rajan

This talk is based on my experiences with issues in development and education in India. I will describe three unfinished journeys: (i) How HIV/AIDS education and awareness lead to a program of 'students as agents of change' through the creation of multimedia presentations on societal issues; (ii) how teaching health to village outreach workers lead to an understanding of adolescent migration from villages to towns in search for jobs and the spectre of alcoholism; and(iii) how teaching health to sex workers in Kolkata lead to an understanding of their closed world.

An Unfinished but Closed Chapter in AAVSO History

NASA Astrophysics Data System (ADS)

Williams, T. R.

2005-08-01

In thirty years of service as the AAVSO's director, Janet Akyüz Mattei left an indelible mark on the organization. The AAVSO underwent nearly continuous expansion of services to members and to the professional community of variable star astronomy during her tenure. Under her leadership, the association flourished and became recognized internationally as the leading variable star organization. Unfortunately, the final recognition that was richly deserved by Mattei, a retirement in which to enjoy the fruits of this effort, was denied her by her sudden illness and passing.

Countdown to 2015 and beyond: fulfilling the health agenda for women and children.

PubMed

Requejo, Jennifer Harris; Bryce, Jennifer; Barros, Aluisio J D; Berman, Peter; Bhutta, Zulfiqar; Chopra, Mickey; Daelmans, Bernadette; de Francisco, Andres; Lawn, Joy; Maliqi, Blerta; Mason, Elizabeth; Newby, Holly; Presern, Carole; Starrs, Ann; Victora, Cesar G

2015-01-31

The end of 2015 will signal the end of the Millennium Development Goal era, when the world can take stock of what has been achieved. The Countdown to 2015 for Maternal, Newborn, and Child Survival (Countdown) has focused its 2014 report on how much has been achieved in intervention coverage in these groups, and on how best to sustain, focus, and intensify efforts to progress for this and future generations. Our 2014 results show unfinished business in achievement of high, sustained, and equitable coverage of essential interventions. Progress has accelerated in the past decade in most Countdown countries, suggesting that further gains are possible with intensified actions. Some of the greatest coverage gaps are in family planning, interventions addressing newborn mortality, and case management of childhood diseases. Although inequities are pervasive, country successes in reaching of the poorest populations provide lessons for other countries to follow. As we transition to the next set of global goals, we must remember the centrality of data to accountability, and the importance of support of country capacity to collect and use high-quality data on intervention coverage and inequities for decision making. To fulfill the health agenda for women and children both now and beyond 2015 requires continued monitoring of country and global progress; Countdown is committed to playing its part in this effort. Copyright © 2015 Elsevier Ltd. All rights reserved.

Prior states: evolution of composition and color in two Barnett Newman paintings

NASA Astrophysics Data System (ADS)

Epley, Bradford A.; Rogge, Corina E.

2015-11-01

The color field paintings of Barnett Newman, one of the great American abstract expressionist painters, are seminal works of the modern era. They feature large flat fields of vibrant colors intended to allow the viewer to connect with the paintings in immediate, visceral ways. Despite the apparent simplicity of his compositions, Newman considered himself an intuitive painter and allowed his compositions to evolve during the painting process. Two paintings in the Menil Collection, Untitled 2 (1950) and Unfinished Painting [Blue and Brown 1970— #2] (1970) display visual evidence of former states, but attempts to elucidate earlier compositions by X-radiography were inconclusive due to the lack of contrast in paint densities. We applied limited sampling and used a handheld X-ray fluorescence spectrometer in a `scanning' manner to determine the color and composition of the previous states of these paintings to help us better understand their evolution. Newman altered his initial cadmium red and alizarin composition in Untitled 2 (1950) by overpainting the alizarin region with a wider band of Mars black paint. He then modulated the surface of the black by partially covering it with a carbonaceous black with a different gloss. For Unfinished Painting [Blue and Brown 1970— #2] (1970), Newman not only changed the cadmium red to an umber but simplified the composition, removing multiple zips and refining it to its current monumental state. This evidence of Newman's decision-making processes permits a tantalizing glimpse of the artist consistently looking both ahead and backward, experimenting and revisiting.

Comparison of latex body paint with wetted gauze wipes for sampling the chemical warfare agents VX and sulfur mustard from common indoor surfaces.

PubMed

Hernon-Kenny, Laura A; Behringer, Deborah L; Crenshaw, Michael D

2016-05-01

Comparison of solvent-wetted gauze with body paint, a peelable surface sampling media, for the sampling of the chemical warfare agents VX and sulfur mustard from nine surfaces was performed. The nine surfaces sampled are those typical of interior public venues and include smooth, rough, porous, and non-porous surfaces. Overall, solvent-wetted gauze (wipes) performed better for the recovery of VX from non-porous surfaces while body paint (BP) performed better for the porous surfaces. The average percent VX recoveries using wipes and BP, respectively, are: finished wood flooring, 86.2%, 71.4%; escalator handrail, 47.3%, 26.7%; stainless steel, 80.5%, 56.1%; glazed ceramic tile, 81.8%, 44.9%; ceiling tile, 1.77%, 13.1%; painted drywall 7.83%, 21.1%; smooth cement, 0.64%, 10.3%; upholstery fabric, 24.6%, 23.1%; unfinished wood flooring, 9.37%, 13.1%. Solvent-wetted gauze performed better for the recovery of sulfur mustard from three of the relatively non-porous surfaces while body paint performed better for the more porous surfaces. The average percent sulfur mustard recoveries using wipes and BP, respectively, are: finished wood flooring, 30.2%, 2.97%; escalator handrail, 4.40%, 4.09%; stainless steel, 21.2%, 3.30%; glazed ceramic tile, 49.7%, 16.7%; ceiling tile, 0.33%, 11.1%; painted drywall 2.05%, 10.6%; smooth cement, 1.20%, 35.2%; upholstery fabric, 7.63%, 6.03%; unfinished wood flooring, 0.90%, 1.74%. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Googling for ghosts: a meditation on writers' block, mourning, and the Holocaust.

PubMed

Flescher, Sylvia

2012-02-01

The author describes her father's experience of being a Holocaust survivor and how his unfinished mourning contributed to her struggle with muteness, her own story being dwarfed by the magnitude of her father's losses. When her non-Jewish mother is chosen to be honored by Yad Vashem, the ceremony proves unexpectedly powerful. The witnessing by community, through the Internet, helps dissolve the shame and isolation, heals some of the trauma, and promotes greater psychological freedom. In creating this paper, the author memorializes her parents and her lost relatives, and succeeds in working through much that had haunted her.

Humidifier disinfectants, unfinished stories

PubMed Central

Choi, Yeyong

2016-01-01

Once released into the air, humidifier disinfectants became tiny nano-size particles, and resulted in chemical bronchoalveolitis. Families had lost their most beloved members, and even some of them became broken. Based on an estimate of two million potential victims who had experienced adverse effects from the use of humidifier disinfectants, we can say that what we have observed was only the tip of the iceberg. Problems of entire airways, as well as other systemic effects, should be examined, as we know these nano-size particles can irritate cell membranes and migrate into systemic circulation. The story of humidifier disinfectant is not finished yet. PMID:26987713

Determination of development factors of the construction market

NASA Astrophysics Data System (ADS)

Kozlova, Olga

2017-10-01

Field of housing construction constantly needs measures of business climate improvement. Provision of housing for citizens remains relatively low. Recently, state has been developing a new set of measures for shared-equity construction improvement. This area has a particular significance and scales for our country. Number of defrauded shareholders in the past allows estimate scales of losses both in the form of unfinished objects in the past and reputation losses of this direction of construction. This article proposes measures which are designed to form an informational base for forecasts of the development of construction and provide a positive result from the applied measures.

No-fault compensation in New Zealand: harmonizing injury compensation, provider accountability, and patient safety.

PubMed

Bismark, Marie; Paterson, Ron

2006-01-01

In 1974 New Zealand jettisoned a tort-based system for compensating medical injuries in favor of a government-funded compensation system. Although the system retained some residual fault elements, it essentially barred medical malpractice litigation. Reforms in 2005 expanded eligibility for compensation to all "treatment injuries," creating a true no-fault compensation system. Compared with a medical malpractice system, the New Zealand system offers more-timely compensation to a greater number of injured patients and more-effective processes for complaint resolution and provider accountability. The unfinished business lies in realizing its full potential for improving patient safety.

In-home drug storage and utilization habits: a Sudanese study.

PubMed

Yousif, M A

2002-01-01

Community drug-use habits were studied in 469 household units in different areas of Sudan. About 97.7% of the investigated families had at least one drug product stored at home. The study revealed a high rate of self-medication (46.9%), repeated use of unfinished stored drugs (55.0%), a high rate of drug exchange among families (59.3%) and poor compliance (71.2%). In Sudan there is still a great need to educate and to motivate the general public regarding the principles of rational drug use in order to safeguard health and avoid economic losses.

2. Credit JPL. Photographic copy of photograph, looking northeast at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Credit JPL. Photographic copy of photograph, looking northeast at unfinished original Test Stand 'C' construction. A portion of the corrugated steel tunnel tube connecting Test Stand 'C' to the first phase of JPL tunnel system construction is visible in the foreground. The steel frame used to support propellant tanks and engine equipment has been erected. The open trap door leads to a chamber inside the Test Stand 'C' base where gaseous nitrogen is distributed via manifolds to Test Stand 'C' control valves. (JPL negative no. 384-1568-A, 19 March 1957) - Jet Propulsion Laboratory Edwards Facility, Test Stand C, Edwards Air Force Base, Boron, Kern County, CA

Germ line mechanics – and unfinished business

PubMed Central

Wessel, Gary M.

2016-01-01

Primordial germ cells are usually made early in the development of an organism. These are the mother of all stem cells that are necessary for propagation of the species, yet use highly diverse mechanisms between organisms. How they are specified, and when and where they form, are central to developmental biology. Using diverse organisms to study this development is illuminating for understanding the mechanics these cells use in this essential function, and for identifying the breadth of evolutionary changes that have occurred between species. This essay emphasizes how echinoderms may contribute to the patch-work quilt of our understanding of germ line formation during embryogenesis. PMID:26970000

Evidence-Informed, Evidence not Used: A Pilot Study of a Sustained Flawed Process and Unfinished Business.

PubMed

Einstein, Stan-Shlomo; Straussner, Shulamith Lala Ashenberg; Johnson, Timothy P; Gartside, Will

2015-01-01

An anonymous, online survey using a convenience sample of global researchers was implemented during 2013-2014 to explore the actual use or nonuse of their research outcomes in a range of interventions in the area of substance use and related disorders. Eighty-seven researchers from 19 countries responded. Based on their self-reports, the utilizability of their findings were either unknown to them or had no effects in terms of substance use treatment, prevention, policies, or professional education. Most respondents did believe, however, that their investigations had an influence on substance use research. The study's limitations are noted.

A Systematic Methodology for Verifying Superscalar Microprocessors

NASA Technical Reports Server (NTRS)

Srivas, Mandayam; Hosabettu, Ravi; Gopalakrishnan, Ganesh

1999-01-01

We present a systematic approach to decompose and incrementally build the proof of correctness of pipelined microprocessors. The central idea is to construct the abstraction function by using completion functions, one per unfinished instruction, each of which specifies the effect (on the observables) of completing the instruction. In addition to avoiding the term size and case explosion problem that limits the pure flushing approach, our method helps localize errors, and also handles stages with interactive loops. The technique is illustrated on pipelined and superscalar pipelined implementations of a subset of the DLX architecture. It has also been applied to a processor with out-of-order execution.

Managed competition in health care and the unfinished agenda

PubMed Central

Enthoven, Alain C.

1986-01-01

A market made up of health care financing and delivery plans and individual consumers, without a carefully drawn set of rules to mitigate market failures, and without mediation by collective action on the demand side, cannot produce efficiency and equity. The concept of competition that can achieve these goals, at least to a satisfactory approximation, is managed competition, with intelligent active agents on the demand side, called sponsors, that contract with the competing health care plans and continuously structure and adjust the market to overcome its tendencies to failure. A great deal remains to be done to achieve the goals envisioned by the “procompetition reformers.” PMID:10311922

Comparison of Quantitative Antifungal Testing Methods for Textile Fabrics.

PubMed

Imoto, Yasuo; Seino, Satoshi; Nakagawa, Takashi; Yamamoto, Takao A

2017-01-01

　Quantitative antifungal testing methods for textile fabrics under growth-supportive conditions were studied. Fungal growth activities on unfinished textile fabrics and textile fabrics modified with Ag nanoparticles were investigated using the colony counting method and the luminescence method. Morphological changes of the fungi during incubation were investigated by microscopic observation. Comparison of the results indicated that the fungal growth activity values obtained with the colony counting method depended on the morphological state of the fungi on textile fabrics, whereas those obtained with the luminescence method did not. Our findings indicated that unique characteristics of each testing method must be taken into account for the proper evaluation of antifungal activity.

Germ Line Mechanics--And Unfinished Business.

PubMed

Wessel, Gary M

2016-01-01

Primordial germ cells are usually made early in the development of an organism. These are the mother of all stem cells that are necessary for propagation of the species, yet use highly diverse mechanisms between organisms. How they are specified, and when and where they form, are central to developmental biology. Using diverse organisms to study this development is illuminating for understanding the mechanics these cells use in this essential function and for identifying the breadth of evolutionary changes that have occurred between species. This essay emphasizes how echinoderms may contribute to the patchwork quilt of our understanding of germ line formation during embryogenesis. © 2016 Elsevier Inc. All rights reserved.

The nondestructive evaluation of high temperature conditioned concrete in conjunction with acoustic emission and x-ray computed tomography

NASA Astrophysics Data System (ADS)

Su, Yu-Min; Hou, Tsung-Chin; Lin, Li-Chiang; Chen, Gwan-Ying; Pan, Huang-Hsing

2016-04-01

Portland Cement Concrete plays a vital part of protecting structural rebars or steels when high-temperature fire incidents occur, that induces loss of evaporate water, dehydration of CH, and deconstruction of C-S-H. The objective of the study was to assess fire-damaged concrete in conjunction with nondestructive evaluation methods of acoustic emission, visual inspections, and X-ray computed tomography. The experimental program was to mix an Ordinary Portland Cement concrete firstly. Concrete cylinders with twenty-day moisture cure were treated in a furnace with 400 and 600°C for one hour. After temperature is cooled down, the concrete cylinders were brought to air or moisture re-curing for ten days. Due to the incident of the furnace, acoustic emission associated with splitting tensile strength test was not able to continue. Future efforts are planned to resume this unfinished task. However, two proposed tasks were executed and completed, namely visual inspections and voids analysis on segments obtained from X-ray CT facility. Results of visual inspections on cross-sectional and cylindrical length of specimens showed that both aggregates and cement pastes turned to pink or red at 600°C. More surface cracks were generated at 600°C than that at 400°C. On the other hand, voids analysis indicated that not many cracks were generated and voids were remedied at 400°C. However, a clear tendency was found that remedy by moisture curing may heal up to 2% voids of the concrete cylinder that was previously subject to 600°C of high temperature conditioning.

From Hallucination to Fiction: The Invention of Meaning in Psychosis.

PubMed

Lippi, Silvia; Lehaire, Célia; Petit, Laetitia

2016-12-01

Taking their inspiration from a case history, the authors explore the effects of a writing workshop led by a professional writer for patients in a psychiatric hospital. This workshop allowed different modes of transference to unfold: transference to the analyst-therapist, transference to the writer who led the workshop, and transference to the other members of the group. The writing activity created conditions in which there could be a movement from hallucination to delusion-a delusion expressed in fiction through the act of writing. Psychotic patients "invent" a writing that remains unfinished and that relates to the experiences of persecution. Writing thus makes it possible for them to tolerate language, through its transformation into writing.

[Charcot, working and 'Male Hysteria': A new approach to the Leçons du mardi (Tuesday Lessons) from the standpoint of psychodynamics of work].

PubMed

Molinier, Pascale

2015-01-01

This paper examines the role of work in Charcot's clinical teaching focusing on cases of male hysteria in The Tuesday's Lessons from 1887 to 1889. Today, we read the work of Charcot in a retrospective way as having ended in a failure: He would have missed the discovery of the sexual unconscious. From the perspective of psychodynamics of work, it appears an alternative way which was present in Charcot, though unfinished, opening on a possible development of a relationship between psychic and body. The role of work in traumatic hysteria has been forgotten by Freud's posterity and this obliteration continues today.

End-of-Life Dreams and Visions: A Qualitative Perspective From Hospice Patients.

PubMed

Nosek, Cheryl L; Kerr, Christopher W; Woodworth, Julie; Wright, Scott T; Grant, Pei C; Kuszczak, Sarah M; Banas, Anne; Luczkiewicz, Debra L; Depner, Rachel M

2015-05-01

End-of-life dreams and visions (ELDVs) are well documented throughout history and across cultures with impact on the dying person and their loved ones having profound meaning. Published studies on ELDVs are primarily based on surveys or interviews with clinicians or families of dead persons. This study uniquely examined patient dreams and visions from their personal perspective. This article reports the qualitative findings from dreams and visions of 63 hospice patients. Inductive content analysis was used to examine the content and subjective significance of ELDVs. Six categories emerged: comforting presence, preparing to go, watching or engaging with the deceased, loved ones waiting, distressing experiences, and unfinished business. © The Author(s) 2014.

Philanthropy and disparities: progress, challenges, and unfinished business.

PubMed

Mitchell, Faith; Sessions, Kathryn

2011-10-01

Philanthropy has invested millions of dollars to reduce disparities in health care and improve minority health. Grants to strengthen providers' cultural competence, diversify health professions, and collect data have improved understanding of and spurred action on disparities. The persistence of disparities in spite of these advances has shifted philanthropic attention toward strategies to change social, economic, and environmental conditions. We argue that these evolving perspectives, along with earlier groundwork, present new opportunities for funders, especially in combination with progress toward universal health coverage. This article looks at how philanthropy has addressed health disparities over the past decade, with a focus on accomplishments, the work remaining to be done, and how funders can help advance the disparities agenda.

Unfinished business in the regulation of shale gas production in the United States.

PubMed

Centner, Terence J; O'Connell, Laura Kathryn

2014-04-01

With increased drilling for natural gas, toxic chemicals used to fracture wells have been introduced into the environment accompanied by allegations of injuries. This article evaluates laws and regulations governing shale gas production to disclose ideas for offering further protection to people and the environment. The aim of the study is to offer state governments ideas for addressing contractual obligations of drilling operators, discerning health risks, disclosing toxic chemicals, and reporting sufficient information to detect problems and enforce regulations. The discussion suggests opportunities for state regulators to become more supportive of public health through greater oversight of shale gas extraction. Copyright © 2014 Elsevier B.V. All rights reserved.

Probability of detection for bolt hole eddy current in extracted from service aircraft wing structures

NASA Astrophysics Data System (ADS)

Underhill, P. R.; Uemura, C.; Krause, T. W.

2018-04-01

Fatigue cracks are prone to develop around fasteners found in multi-layer aluminum structures on aging aircraft. Bolt hole eddy current (BHEC) is used for detection of cracks from within bolt holes after fastener removal. In support of qualification towards a target a90/95 (detect 90% of cracks of depth a, 95% of the time) of 0.76 mm (0.030"), a preliminary probability of detection (POD) study was performed to identify those parameters whose variation may keep a bolt hole inspection from attaining its goal. Parameters that were examined included variability in lift-off due to probe type, out-of-round holes, holes with diameters too large to permit surface-contact of the probe and mechanical damage to the holes, including burrs. The study examined the POD for BHEC of corner cracks in unfinished fastener holes extracted from service material. 68 EDM notches were introduced into two specimens of a horizontal stabilizer from a CC-130 Hercules aircraft. The fastener holes were inspected in the unfinished state, simulating potential inspection conditions, by 7 certified inspectors using a manual BHEC setup with an impedance plane display and also with one inspection conducted utilizing a BHEC automated C-Scan apparatus. While the standard detection limit of 1.27 mm (0.050") was achieved, given the a90/95 of 0.97 mm (0.039"), the target 0.76 mm (0.030") was not achieved. The work highlighted a number of areas where there was insufficient information to complete the qualification. Consequently, a number of recommendations were made. These included; development of a specification for minimum probe requirements; criteria for condition of the hole to be inspected, including out-of-roundness and presence of corrosion pits; statement of range of hole sizes; inspection frequency and data display for analysis.

Scanning the landscape of genome architecture of non-O1 and non-O139 Vibrio cholerae by whole genome mapping reveals extensive population genetic diversity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chapman, Carol; Henry, Matthew; Bishop-Lilly, Kimberly A.

Historically, cholera outbreaks have been linked to V. cholerae O1 serogroup strains or its derivatives of the O37 and O139 serogroups. A genomic study on the 2010 Haiti cholera outbreak strains highlighted the putative role of non O1/non-O139 V. cholerae in causing cholera and the lack of genomic sequences of such strains from around the world. Here we address these gaps by scanning a global collection of V. cholerae strains as a first step towards understanding the population genetic diversity and epidemic potential of non O1/non-O139 strains. Whole Genome Mapping (Optical Mapping) based bar coding produces a high resolution, orderedmore » restriction map, depicting a complete view of the unique chromosomal architecture of an organism. To assess the genomic diversity of non-O1/non-O139 V. cholerae, we applied a Whole Genome Mapping strategy on a well-defined and geographically and temporally diverse strain collection, the Sakazaki serogroup type strains. Whole Genome Map data on 91 of the 206 serogroup type strains support the hypothesis that V. cholerae has an unprecedented genetic and genomic structural diversity. Interestingly, we discovered chromosomal fusions in two unusual strains that possess a single chromosome instead of the two chromosomes usually found in V. cholerae. We also found pervasive chromosomal rearrangements such as duplications and indels in many strains. The majority of Vibrio genome sequences currently in public databases are unfinished draft sequences. The Whole Genome Mapping approach presented here enables rapid screening of large strain collections to capture genomic complexities that would not have been otherwise revealed by unfinished draft genome sequencing and thus aids in assembling and finishing draft sequences of complex genomes. Furthermore, Whole Genome Mapping allows for prediction of novel V. cholerae non-O1/non-O139 strains that may have the potential to cause future cholera outbreaks.« less

Scanning the landscape of genome architecture of non-O1 and non-O139 Vibrio cholerae by whole genome mapping reveals extensive population genetic diversity.

PubMed

Chapman, Carol; Henry, Matthew; Bishop-Lilly, Kimberly A; Awosika, Joy; Briska, Adam; Ptashkin, Ryan N; Wagner, Trevor; Rajanna, Chythanya; Tsang, Hsinyi; Johnson, Shannon L; Mokashi, Vishwesh P; Chain, Patrick S G; Sozhamannan, Shanmuga

2015-01-01

Historically, cholera outbreaks have been linked to V. cholerae O1 serogroup strains or its derivatives of the O37 and O139 serogroups. A genomic study on the 2010 Haiti cholera outbreak strains highlighted the putative role of non O1/non-O139 V. cholerae in causing cholera and the lack of genomic sequences of such strains from around the world. Here we address these gaps by scanning a global collection of V. cholerae strains as a first step towards understanding the population genetic diversity and epidemic potential of non O1/non-O139 strains. Whole Genome Mapping (Optical Mapping) based bar coding produces a high resolution, ordered restriction map, depicting a complete view of the unique chromosomal architecture of an organism. To assess the genomic diversity of non-O1/non-O139 V. cholerae, we applied a Whole Genome Mapping strategy on a well-defined and geographically and temporally diverse strain collection, the Sakazaki serogroup type strains. Whole Genome Map data on 91 of the 206 serogroup type strains support the hypothesis that V. cholerae has an unprecedented genetic and genomic structural diversity. Interestingly, we discovered chromosomal fusions in two unusual strains that possess a single chromosome instead of the two chromosomes usually found in V. cholerae. We also found pervasive chromosomal rearrangements such as duplications and indels in many strains. The majority of Vibrio genome sequences currently in public databases are unfinished draft sequences. The Whole Genome Mapping approach presented here enables rapid screening of large strain collections to capture genomic complexities that would not have been otherwise revealed by unfinished draft genome sequencing and thus aids in assembling and finishing draft sequences of complex genomes. Furthermore, Whole Genome Mapping allows for prediction of novel V. cholerae non-O1/non-O139 strains that may have the potential to cause future cholera outbreaks.

Sweet waste extract uptake by a mosquito vector: Survival, biting, fecundity responses, and potential epidemiological significance.

PubMed

Dieng, Hamady; Satho, Tomomitsu; Abang, Fatimah; Meli, Nur Khairatun Khadijah Binti; Ghani, Idris A; Nolasco-Hipolito, Cirilo; Hakim, Hafijah; Miake, Fumio; Ahmad, Abu Hassan; Noor, Sabina; Zuharah, Wan Fatma; Ahmad, Hamdan; Majid, Abdul Hafiz A; Morales Vargas, Ronald E; Morales, Noppawan P; Attrapadung, Siriluck; Noweg, Gabriel Tonga

2017-05-01

In nature, adult mosquitoes typically utilize nectar as their main energy source, but they can switch to other as yet unidentified sugary fluids. Contemporary lifestyles, with their associated unwillingness to consume leftovers and improper disposal of waste, have resulted in the disposal of huge amounts of waste into the environment. Such refuse often contains unfinished food items, many of which contain sugar and some of which can collect water from rain and generate juices. Despite evidence that mosquitoes can feed on sugar-rich suspensions, semi-liquids, and decaying fruits, which can be abundant in garbage sites, the impacts of sweet waste fluids on dengue vectors are unknown. Here, we investigated the effects of extracts from some familiar sweet home waste items on key components of vectorial capacity of Aedes aegypti. Adult mosquitoes were fed one of five diets in this study: water (WAT); sucrose (SUG); bakery product (remnant of chocolate cake, BAK); dairy product (yogurt, YOG); and fruit (banana (BAN). Differences in survival, response time to host, and egg production were examined between groups. For both males and females, maintenance on BAK extract resulted in marked survival levels that were similar to those seen with SUG. Sweet waste extracts provided better substrates for survival compared to water, but this superiority was mostly seen with BAK. Females maintained on BAK, YOG, and BAN exhibited shorter response times to a host compared to their counterparts maintained on SUG. The levels of egg production were equivalent in waste extract- and SUG-fed females. The findings presented here illustrate the potential of sweet waste-derived fluids to contribute to the vectorial capacity of dengue vectors and suggest the necessity of readdressing the issue of waste disposal, especially that of unfinished sweet foods. Such approaches can be particularly relevant in dengue endemic areas where rainfall is frequent and waste collection infrequent. Copyright © 2017 Elsevier B.V. All rights reserved.

Scanning the landscape of genome architecture of non-O1 and non-O139 Vibrio cholerae by whole genome mapping reveals extensive population genetic diversity

DOE PAGES

Chapman, Carol; Henry, Matthew; Bishop-Lilly, Kimberly A.; ...

2015-03-20

Historically, cholera outbreaks have been linked to V. cholerae O1 serogroup strains or its derivatives of the O37 and O139 serogroups. A genomic study on the 2010 Haiti cholera outbreak strains highlighted the putative role of non O1/non-O139 V. cholerae in causing cholera and the lack of genomic sequences of such strains from around the world. Here we address these gaps by scanning a global collection of V. cholerae strains as a first step towards understanding the population genetic diversity and epidemic potential of non O1/non-O139 strains. Whole Genome Mapping (Optical Mapping) based bar coding produces a high resolution, orderedmore » restriction map, depicting a complete view of the unique chromosomal architecture of an organism. To assess the genomic diversity of non-O1/non-O139 V. cholerae, we applied a Whole Genome Mapping strategy on a well-defined and geographically and temporally diverse strain collection, the Sakazaki serogroup type strains. Whole Genome Map data on 91 of the 206 serogroup type strains support the hypothesis that V. cholerae has an unprecedented genetic and genomic structural diversity. Interestingly, we discovered chromosomal fusions in two unusual strains that possess a single chromosome instead of the two chromosomes usually found in V. cholerae. We also found pervasive chromosomal rearrangements such as duplications and indels in many strains. The majority of Vibrio genome sequences currently in public databases are unfinished draft sequences. The Whole Genome Mapping approach presented here enables rapid screening of large strain collections to capture genomic complexities that would not have been otherwise revealed by unfinished draft genome sequencing and thus aids in assembling and finishing draft sequences of complex genomes. Furthermore, Whole Genome Mapping allows for prediction of novel V. cholerae non-O1/non-O139 strains that may have the potential to cause future cholera outbreaks.« less

The web of Penelope. Regulating women's night work: an unfinished job?

PubMed

Riva, Michele A; Scordo, Francesco; Turato, Massimo; Messina, Giovanni; Cesana, Giancarlo

2015-12-01

Even though unhealthy consequences of night work for women have been evidenced by international scientific literature only in recent years, they were well acknowledged from ancient times. This essay traces the historical evolution of women's health conditions at work, focusing specifically on nocturnal work. Using the legendary web of Penelope of ancient Greek myths as a metaphor, the paper analyses the early limitations of night-work for women in pre-industrial era and the development of a modern international legislation on this issue, aimed at protecting women's health at the beginning of the twentieth century. The reform of national legislations in a gender-neutral manner has recently abolished gender disparities in night-work, but it seems it also reduced women's protection at work.

The relationship between loss of parents in the holocaust, intrusive memories, and distress among child survivors.

PubMed

Letzter-Pouw, Sonia; Werner, Perla

2012-04-01

The prevalence of intrusive memories of the Holocaust and their relationship to distress was examined among 272 child survivors in Israel. Using attachment theory as a conceptual framework, the authors also examined the effects of type of experience and loss of parents in the Holocaust, psychological resources, other life events, and sociodemographic characteristics on distress and symptomatic behavior. Eighty five percent of the participants reported suffering from intrusive memories. Structural equation modeling showed that survivors who lost one or both parents in the Holocaust suffered more distress because of more intrusive memories. These findings suggest that intrusive memories may be part of unfinished mourning processes related to the loss of parents in the Holocaust. © 2012 American Orthopsychiatric Association.

Success, Failure, and Unfinished Business of Education, Prevention, Policy, and Intervention Programs on Substance Misuse in Brazilian Sport.

PubMed

Santos, Azenildo M

2015-01-01

The current Brazilian situation is such that it is difficult to obtain a worldwide evaluation of failure in education, intervention, or prevention programs. How fragile Brazil's anti-doping system is, its appropriateness as well as its relevance, with needed policy infrastructures for achieving the selected goals, and how wide the gap is between education and prevention program effectiveness between high-performance athletes and recreational practitioners who just want to look good. An additional concern, and ever present flaw regarding Brazil's "common sportsman" in day-to-day society is their not receiving known and necessary "sports education," enabling the development of an "at-risk" population for self-harm. Reflections on public health policy are noted.

Unfinished feticide: a legal commentary.

PubMed Central

Brazier, Margaret

1990-01-01

Jansen expresses concern as to the legal implications of both selective reduction of pregnancy and unsuccessful attempts at termination of pregnancy using mifepristone. This commentary examines the legality of both procedures and concludes that Jansen is over-optimistic in his belief that neither procedure is likely to fall foul of the criminal laws on induced abortion. By contrast his anxieties about civil liability arising from the subsequent live birth of a damaged infant are, it is suggested, unnecessarily pessimistic. Such an action is most unlikely to succeed if brought by the infant herself and any claim on the part of the mother will normally be dependent on proof of negligence. The commentary focusses on the law in England with relevant references to other common law jurisdictions. PMID:11642779

Measurement problem in Program Universe. Revision

NASA Astrophysics Data System (ADS)

Noyes, H. P.; Gefwert, C.; Manthey, M. J.

1985-07-01

The measurement problem of contemporary physics is in our view an artifact of its philosophical and mathematical underpinnings. We describe a new philosophical view of theory formation, rooted in Wittgenstein, and Bishop's and Martin-Loef's constructivity, which obviates such discussions. We present an unfinished, but very encouraging, theory which is compatible with this philosophical framework. The theory is based on the concepts of counting and combinatorics in the framework provided by the combinatorial hierarchy, a unique hierarchy of bit strings which interact by an operation called discrimination. Measurement criteria incorporate c, h-bar and m/sub p/ or (not and) G. The resulting theory is discrete throughout, contains no infinities, and, as far as we have developed it, is in agreement with quantum mechanical and cosmological fact.

Tracking ion irradiation effects using buried interface devices

NASA Astrophysics Data System (ADS)

Cutshall, D. B.; Kulkarni, D. D.; Miller, A. J.; Harriss, J. E.; Harrell, W. R.; Sosolik, C. E.

2018-05-01

We discuss how a buried interface device, specifically a metal-oxide-semiconductor (MOS) capacitor, can be utilized to track effects of ion irradiation on insulators. We show that the exposure of oxides within unfinished capacitor devices to ions can lead to significant changes in the capacitance of the finished devices. For multicharged ions, these capacitive effects can be traced to defect production within the oxide and ultimately point to a role for charge-dependent energy loss. In particular, we attribute the stretchout of the capacitance-voltage curves of MOS devices that include an irradiated oxide to the ion irradiation. The stretchout shows a power law dependence on the multicharged ion charge state (Q) that is similar to that observed for multicharged ion energy loss in other systems.

What do Non-clergy Spiritual Care Providers Contribute to End of Life Care in Israel? A Qualitative Study.

PubMed

Pagis, Michal; Tal, Orly; Cadge, Wendy

2017-04-01

Spiritual care is an increasingly important component of end of life care. As it emerges in Israel, it is intentionally built on a nonclerical model. Based on interviews with spiritual care providers in Israel, we find that they help patients and families talk about death and say goodbyes. They encourage the wrapping up of unfinished business, offer diverse cultural resources that can provide meaning, and use presence and touch to produce connection. As spiritual care emerges in Israel, providers are working with patients at the end of life in ways they see as quite distinct from rabbis. They offer broad frames of meaning to which patients from a range of religious traditions can connect.

Ecological economics and institutional change.

PubMed

Krall, Lisi; Klitgaard, Kent

2011-02-01

Ecological economics remains unfinished in its effort to provide a framework for transforming the economy so that it is compatible with biophysical limits. Great strides have been made in valuing natural capital and ecosystem services and recognizing the need to limit the scale of economic activity, but the question of how to effectively transform the economy to limit the scale of economic activity remains unclear. To gain clarity about the institutional changes necessary to limit the scale of economic activity, it is essential that ecological economics understands the limitations of its neoclassical roots and expands its theoretical framework to include how markets are embedded in social and institutional structures. This has long been the domain of institutional economics and heterodox political economy. © 2011 New York Academy of Sciences.

The unfinished assignment: Educating Moroccan women for development

NASA Astrophysics Data System (ADS)

Belhachmi, Zakia

1987-12-01

Western theories of development, and the resulting strategies and planning represent major structural barriers to Moroccan Women's Liberation. The author advocates a shift from current anti-participatory strategies to a new people-oriented approach, emphasizing the multiple roles of women within an integrated strategy. This involves linking educational projects with other parts of the infrastructure. Morocco's `way out' of exogenous development, the author contends, is contingent upon an adequate management of the educational system both at the institutional and personal levels. Therefore, educating women can be considered a sine qua non in optimizing conditions leading to endogenous development. The foundation is the establishment or strengthening of a whole infrastructure for the creation, transmission, and application of alternative methods likely to sustain socio-economic opportunities leading to Morocco's self-reliance.

An Artist's Role in Science Communication

NASA Astrophysics Data System (ADS)

Droppo, R.

2013-04-01

“Considering the tradition of distant travelers, the range of their countrymen's desire to know, the government camp on Cornwallis Island seemed an impoverished outpost. There were no provisions there for painters, for musicians, for novelists. And there were no historians there. If the quest for knowledge in any remote place is meant in an egalitarian sense to be useful to all, then this is a peculiar situation. Yet it is no different from what one would find in a hundred other such remote places around the world. Whenever we seek to take swift and efficient possession of places completely new to us, places we neither own nor understand, our first and often only assessment is a scientific one. And so our evaluations remain unfinished.” Arctic Dreams p. 228 by Barry Lopez.

Identification, definition and mapping of terrestrial ecosystems in interior Alaska

NASA Technical Reports Server (NTRS)

Anderson, J. H. (Principal Investigator)

1973-01-01

The author has identified the following significant results. Two new, as yet unfinished vegetation maps are presented. These tend further to substantiate the belief that ERTS-1 imagery is a valuable mapping tool. Newly selected scenes show that vegetation interpretations can be refined through use of non-growing season imagery, particularly through the different spectral characteristics of vegetation lacking foliage and through the effect of vegetation structure on apparent snow cover. Scenes now are available for all test area north of the Alaska Range except Mt. McKinley National Park. No support was obtained for the hypothesis that similar interband ratios, from two areas apparently different spectrally because of different sun angles, would indicate similar surface features. However, attempts to test this hypothesis have so far been casual.

Noviodunum Roman Fortress. a Survey on a City Wall Section

NASA Astrophysics Data System (ADS)

Teodor, A.; Teodor, E. S.; Florea, M. S.; Popescu, M. A.

2011-09-01

The paper presents in detail the method used to acquire 2D and 3D representations for the Large Tower of the Roman fortress from Noviodunum (Isaccea, Tulcea County). The available implements were a total station, a digital camera and some software for handling data. The method is not new by any rate, but well fitted to the aims - recording archaeological data on ruined but massif walls, with rough surfaces - and with a limited budget. Lately considered as a low cost procedure, laser scanning is still costly and rare in some East-European countries. Our method, as simple as it is, provides reliable data as a 3D survey, along texture details, at the lowest price, on unfinished fieldwork, preserving and picturing a stage of knowledge about the site and the architectural bodies.

Focusing and the healing sequence: reclaiming authentic emotions as an aid to communication and well-being in medicine.

PubMed

Bub, Barry

2007-01-01

The reality and prevalence of suicide presents us with myriad questions and levels of concern. What does the dying person do in the face of seemingly endless adversity, loss, fear of abandonment, disfigurement, dependence, and/or unmitigated pain? Everyone working in end-of-life palliative care keeps these very concerns foremost in heart and mind. Yet how can providers process the unfinished spiritual and emotional business that remains when one of our former patients indeed nosedives into Jobian loss and makes the ultimate decision? This dilemma has been a constant companion in the end-of-life terrain, and our guest author Dr Barry Bub brings a wealth of insight into the healing power of authentic emotion in his narrative about the death of the gourmet chef named Ben.

NTCP opens the door for hepatitis B virus infection.

PubMed

Yan, Huan; Liu, Yang; Sui, Jianhua; Li, Wenhui

2015-09-01

A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a much-needed and convenient cell culture system for the viruses. Identification of NTCP as a functional receptor for HBV has significantly advanced our understanding of the viral life cycle and opened new opportunities for developing anti-HBV interventions. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B". Copyright © 2015 Elsevier B.V. All rights reserved.

Task analysis exemplified: the process of resolving unfinished business.

PubMed

Greenberg, L S; Foerster, F S

1996-06-01

The steps of a task-analytic research program designed to identify the in-session performances involved in resolving lingering bad feelings toward a significant other are described. A rational-empirical methodology of repeatedly cycling between rational conjecture and empirical observations is demonstrated as a method of developing an intervention manual and the components of client processes of resolution. A refined model of the change process developed by these procedures is validated by comparing 11 successful and 11 unsuccessful performances. Four performance components-intense expression of feeling, expression of need, shift in representation of other, and self-validation or understanding of the other-were found to discriminate between resolution and nonresolution performances. These components were measured on 4 process measures: the Structural Analysis of Social Behavior, the Experiencing Scale, the Client's Emotional Arousal Scale, and a need scale.

The Texas Advanced Directive Law: Unfinished Business.

PubMed

Kapottos, Michael; Youngner, Stuart

2015-01-01

The Texas Advance Directive Act allows physicians and hospitals to overrule patient or family requests for futile care. Purposefully not defining futility, the law leaves its determination in specific cases to an institutional process. While the law has received several criticisms, it does seem to work constructively in the cases that come to the review process. We introduce a new criticism: While the law has been justified by an appeal to professional values such as avoiding harm to patients, avoiding the provision of unseemly care, and good stewardship of medical resources, it is applied incompletely. It allows physicians and institutional committees to refuse "futile" treatments desired by patients and families while at the same time providing no way of regulating physicians who recommend or even push "futile" treatments in similar cases. In this sense, the TADA is incomplete on its own terms.

Diagnosing a Failed Proof in Fault-Tolerance: A Disproving Challenge Problem

NASA Technical Reports Server (NTRS)

Pike, Lee; Miner, Paul; Torres-Pomales, Wilfredo

2006-01-01

This paper proposes a challenge problem in disproving. We describe a fault-tolerant distributed protocol designed at NASA for use in a fly-by-wire system for next-generation commercial aircraft. An early design of the protocol contains a subtle bug that is highly unlikely to be caught in fault injection testing. We describe a failed proof of the protocol's correctness in a mechanical theorem prover (PVS) with a complex unfinished proof conjecture. We use a model checking suite (SAL) to generate a concrete counterexample to the unproven conjecture to demonstrate the existence of a bug. However, we argue that the effort required in our approach is too high and propose what conditions a better solution would satisfy. We carefully describe the protocol and bug to provide a challenging but feasible case study for disproving research.

Suggesting a new European language policy.

PubMed

Nelde, Peter H

2004-01-01

Conflict is the most intriguing aspect of contact linguistics. Throughout history ever since the Tower of Babel was left unfinished, contacts between speakers of different languages have unavoidably resulted in conflicts between speakers of those languages. Without any doubt, the European Union (EU)--above all after the decision to enlarge the community--has accepted the multidisciplinary symbolic function of language and culture as a basis for European political unification. Accordingly, European Union policy makers have had to analyze conflicts caused by monolingualism and multilingualism, all aspects of contact linguistics. Can these conflicts be solved, minimized or neutralized by strategies of language planning, language policies and language politics? Initial results of European language policy strategies permit at least a cautious measure of optimism and open broad perspectives for the future of a New Multilingualism which will be discussed in our contribution.

Unfinished business: ongoing ethical exceptionalism in the oversight of human pluripotent stem cell research in Canada.

PubMed

Baylis, Françoise; Downie, Jocelyn

2012-01-01

In this article, we critically examine the arguments for and against the exceptional status given human pluripotent stem cell research in Canada (through the latest [December 2010] revision of the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans), and conclude that this exceptionalism is unwarranted and ethically unsound. In our view, the three federal research granting agencies should honor their longstanding commitment that researchers, research sponsors, and Research Ethics Boards in Canada have access to "a single reference document for all research involving humans conducted under the auspices of institutions eligible for Agency funding." As well, responsibility for the development, interpretation, and implementation of Canada's research ethics guidelines should be under the authority of a single oversight body that is independent of the federal research granting Agencies.

The theory of reference values: an unfinished symphony.

PubMed

Siest, Gerard; Henny, Joseph; Gräsbeck, Ralph; Wilding, Peter; Petitclerc, Claude; Queraltó, Josep M; Hyltoft Petersen, Peter

2013-01-01

The history of the theory of reference values can be written as an unfinished symphony. The first movement, allegro con fuoco, played from 1960 to 1980: a mix of themes devoted to the study of biological variability (intra-, inter-individual, short- and long-term), preanalytical conditions, standardization of analytical methods, quality control, statistical tools for deriving reference limits, all of them complex variations developed on a central melody: the new concept of reference values that would replace the notion of normality whose definition was unclear. Additional contributions (multivariate reference values, use of reference limits from broad sets of patient data, drug interferences) conclude the movement on the variability of laboratory tests. The second movement, adagio, from 1980 to 2000, slowly develops and implements initial works. International and national recommendations were published by the IFCC-LM (International Federation of Clinical Chemistry and Laboratory Medicine) and scientific societies [French (SFBC), Spanish (SEQC), Scandinavian societies…]. Reference values are now topics of many textbooks and of several congresses, workshops, and round tables that are organized all over the world. Nowadays, reference values are part of current practice in all clinical laboratories, but not without difficulties, particularly for some laboratories to produce their own reference values and the unsuitability of the concept with respect to new technologies such as HPLC, GCMS, and PCR assays. Clinicians through consensus groups and practice guidelines have introduced their own tools, the decision limits, likelihood ratios and Reference Change Value (RCV), creating confusion among laboratorians and clinicians in substituting reference values and decision limits in laboratory reports. The rapid development of personalized medicine will eventually call for the use of individual reference values. The beginning of the second millennium is played allegro ma non-troppo from 2000 to 2012: the theory of reference values is back into fashion. The need to revise the concept is emerging. The manufacturers make a friendly pressure to facilitate the integration of Reference Intervals (RIs) in their technical documentation. Laboratorians are anxiously awaiting the solutions for what to do. The IFCC-LM creates Reference Intervals and Decision Limits Committee (C-RIDL) in 2005. Simultaneously, a joint working group IFCC-CLSI is created on the same topic. In 2008 the initial recommendations of IFCC-LM are revised and new guidelines are published by the Clinical and Laboratory Standards Institute (CLSI C28-A3). Fundamentals of the theory of reference values are not changed, but new avenues are explored: RIs transference, multicenter reference intervals, and a robust method for deriving RIs from small number of subjects. Concomitantly, other statistical methods are published such as bootstraps calculation and partitioning procedures. An alternative to recruiting healthy subjects proposes the use of biobanks conditional to the availability of controlled preanalytical conditions and of bioclinical data. The scope is also widening to include veterinary biology! During the early 2000s, several groups proposed the concept of 'Universal RIs' or 'Global RIs'. Still controversial, their applications await further investigations. The fourth movement, finale: beyond the methodological issues (statistical and analytical essentially), important questions remain unanswered. Do RIs intervene appropriately in medical decision-making? Are RIs really useful to the clinicians? Are evidence-based decision limits more appropriate? It should be appreciated that many laboratory tests represent a continuum that weakens the relevance of RIs. In addition, the boundaries between healthy and pathological states are shady areas influenced by many biological factors. In such a case the use of a single threshold is questionable. Wherever it will apply, individual reference values and reference change values have their place. A variation on an old theme! It is strange that in the period of personalized medicine (that is more stratified medicine), the concept of reference values which is based on stratification of homogeneous subgroups of healthy people could not be discussed and developed in conjunction with the stratification of sick patients. That is our message for the celebration of the 50th anniversary of Clinical Chemistry and Laboratory Medicine. Prospects are broad, enthusiasm is not lacking: much remains to be done, good luck for the new generations!

KSC-2009-1694

NASA Image and Video Library

2009-02-18

CAPE CANAVERAL, Fla. – At the Astrotech payload processing facility in Titusville, Fla., the top of the canister is lifted for a move to the unfinished canister at left. The canister surrounding NASA's Kepler spacecraft provides protection during the spacecraft's transport to the pad. The liftoff of Kepler aboard a Delta II rocket is currently targeted for 10:48 p.m. EST March 5 from Pad 17-B. Kepler is designed to survey more than 100,000 stars in our galaxy to determine the number of sun-like stars that have Earth-size and larger planets, including those that lie in a star's "habitable zone," a region where liquid water, and perhaps life, could exist. If these Earth-size worlds do exist around stars like our sun, Kepler is expected to be the first to find them and the first to measure how common they are. Photo credit: NASA/Troy Cryder

OSLay: optimal syntenic layout of unfinished assemblies.

PubMed

Richter, Daniel C; Schuster, Stephan C; Huson, Daniel H

2007-07-01

The whole genome shotgun approach to genome sequencing results in a collection of contigs that must be ordered and oriented to facilitate efficient gap closure. We present a new tool OSLay that uses synteny between matching sequences in a target assembly and a reference assembly to layout the contigs (or scaffolds) in the target assembly. The underlying algorithm is based on maximum weight matching. The tool provides an interactive visualization of the computed layout and the result can be imported into the assembly editing tool Consed to support the design of primer pairs for gap closure. To enhance efficiency in the gap closure phase of a genome project it is crucial to know which contigs are adjacent in the target genome. Related genome sequences can be used to layout contigs in an assembly. OSLay is freely available from: http://www-ab.informatik.unituebingen.de/software/oslay.

Oil crises and African economies: oil wave on a tidal flood of industrial price inflation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, W.R.; Wilson, E.J. III

Escalating oil-import prices have left the developing African economies with high debts, unfinished projects, and bitterness over what they see as economic assassination by OPEC. Much of the blame for their suffering, however, can be placed on African leaders who failed to control internal factors. The authors review the impact of OPEC's pricing changes in terms of its relation to internal financial and energy characteristics and the purchasing and policy choices made by African nations in response to the price increases. They describe the African nations' ability to solve their energy and economic problems as less favorable than other less-developedmore » countries. The richer OPEC and industrial countries can do more than they are to help relieve the economic strain and to diversify African energy sources. 53 references, 7 tables. (DCK)« less

Rechargeable lithium-ion cell state of charge and defect detection by in-situ inside-out magnetic resonance imaging.

PubMed

Ilott, Andrew J; Mohammadi, Mohaddese; Schauerman, Christopher M; Ganter, Matthew J; Jerschow, Alexej

2018-05-03

When and why does a rechargeable battery lose capacity or go bad? This is a question that is surprisingly difficult to answer; yet, it lies at the heart of progress in the fields of consumer electronics, electric vehicles, and electrical storage. The difficulty is related to the limited amount of information one can obtain from a cell without taking it apart and analyzing it destructively. Here, we demonstrate that the measurement of tiny induced magnetic field changes within a cell can be used to assess the level of lithium incorporation into the electrode materials, and diagnose certain cell flaws that could arise from assembly. The measurements are fast, can be performed on finished and unfinished cells, and most importantly, can be done nondestructively with cells that are compatible with commercial design requirements with conductive enclosures.

Staging scientific controversies: a gallery test on science museums' interactivity.

PubMed

Yaneva, Albena; Rabesandratana, Tania Mara; Greiner, Birgit

2009-01-01

The "transfer" model in science communication has been addressed critically from different perspectives, while the advantages of the interactive model have been continuously praised. Yet, little is done to account for the specific role of the interactive model in communicating "unfinished science." The traditional interactive methods in museums are not sufficient to keep pace with rapid scientific developments. Interactive exchanges between laypeople and experts are thought mainly through the lens of a dialogue that is facilitated and framed by the traditional "conference room" architecture. Drawing on the results of a small-scale experiment in a gallery space, we argue for the need for a new "architecture of interaction" in museum settings based on art installation and simulation techniques, which will enhance the communication potentials of science museums and will provide conditions for a fruitful even-handed exchange of expert and lay knowledge.

A note on consummation and termination.

PubMed

Calef, V; Weinshel, E M

1983-01-01

The sensation sometimes expressed by analytic patients, most notably during termination of having left some "unfinished business" (to which they hope to return) is not necessarily simply a judgment about the analysis; frequently it is an affective component of the wish for consummation which has not been granted by the analysis. Simultaneously, it expresses the defense against that very consummation. The wish to give the analyst a gift is in some sense the direct opposite, or more correctly, expresses the defense more openly as a bribe and warning to the analyst that he should not expect or hope for consummation of the instinctual wishes which have been the center of analytic work; i.e., it is a defense against the fulfillment of those wishes almost as if the analyst, by attempting to analyze them, insists upon their enactment. Nevertheless, and despite the apparent contradiction, both affects, which serve similar functions, may appear simultaneously.

Preparation of TbCu7-type Sm-Fe powders by low-temperature HDDR treatment

NASA Astrophysics Data System (ADS)

Takagi, Kenta; Jinno, Miho; Ozaki, Kimihiro

2018-05-01

Low-temperature hydrogen-disproportionation-desorption-recombination (HDDR) treatment of Sm-Fe alloy powder was conducted to prepare a metastable TbCu7 type Sm-Fe alloy powder with a grain size of more than a few hundreds of nanometers. While a treatment temperature above 700 °C produced the familiar Th2Zn17 type alloy, one below 600 °C resulted in successful synthesis of the TbCu7 type Sm-Fe alloy with submicron-size grains. This TbCu7 type alloy powder, however, showed no significant improvement in magnetic properties compared to the Th2Zn17 type, as its composition was estimated to be near SmFe8.5 and thus did not achieve the expected Fe-rich composition. Therefore, cross-sectional transmission electron microscope observation of the unfinished TbCu7 type alloy powder was conducted in order to explore means of forming the Fe-rich phase.

The recall of information from working memory. Insights from behavioural and chronometric perspectives.

PubMed

Towse, John N; Cowan, Nelson; Hitch, Graham J; Horton, Neil J

2008-01-01

We describe and evaluate a recall reconstruction hypothesis for working memory (WM), according to which items can be recovered from multiple memory representations. Across four experiments, participants recalled memoranda that were either integrated with or independent of the sentence content. We found consistently longer pauses accompanying the correct recall of integrated compared with independent words, supporting the argument that sentence memory could scaffold the access of target items. Integrated words were also more likely to be recalled correctly, dependent on the details of the task. Experiment 1 investigated the chronometry of spoken recall for word span and reading span, with participants completing an unfinished sentence in the latter case. Experiments 2 and 3 confirm recall time differences without using word generation requirements, while Experiment 4 used an item and order response choice paradigm with nonspoken responses. Data emphasise the value of recall timing in constraining theories of WM functioning.

Clausewitz, nonlinearity, and the unpredictability of war

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beyerchen, A.

Despite the frequent invocations of his name in recent years, especially during the Gulf War, there is something deeply perplexing about the work of Carl von Clausewitz (1780-1831). In particular, his unfinished magnum opus On War seems to offer a theory of war, at the same time that is perversely denies many of the fundamental preconditions of theory as such - simplification, generalization and prediction, among others. The book continues to draw the attention of both soldiers and theorists of war, although soldiers often find the ideas of Clausewitz too philosophical to appear practical, while analysts usually find his thoughtsmore » too empirical to seem elegant. Members of both groups sense that there is too much truth in what he writes to ignore him. Yet, as the German historian Hans Rothfels has bluntly put it, Clausewitz is an author more quoted than actually read.' 84 refs.« less

A Thematic Literature Review: The Importance of Providing Spiritual Care for End-of-Life Patients Who Have Experienced Transcendence Phenomena.

PubMed

Broadhurst, Kathleen; Harrington, Ann

2016-11-01

The purpose of this review was to investigate within the literature the link between transcendent phenomena and peaceful death. The objectives were firstly to acknowledge the importance of such experiences and secondly to provide supportive spiritual care to dying patients. Information surrounding the aforementioned concepts is underreported in the literature. The following 4 key themes emerged: spiritual comfort; peaceful, calm death; spiritual transformation; and unfinished business The review established the importance of transcendence phenomena being accepted as spiritual experiences by health care professionals. Nevertheless, health care professionals were found to struggle with providing spiritual care to patients who have experienced them. Such phenomena are not uncommon and frequently result in peaceful death. Additionally, transcendence experiences of dying patients often provide comfort to the bereaved, assisting them in the grieving process. © The Author(s) 2015.

Reflections: Neurology and The Humanities. The case of the locked house. The finished mystery.

PubMed

Joynt, Robert J; Kempster, Peter A; Lee, Andrew J

2014-08-12

After the death in 2012 of Dr. Robert Joynt, who served Neurology® as CPC Section Editor, an unfinished manuscript was found on his computer. It would have been his sixth Sherlock Holmes pastiche. Intrigued by the story but deflated at the lack of an ending, the editors published the case in the September 10, 2013, issue of Neurology and requested that readers finish it. A panel of editors reviewed over 30 submissions and the top 4 were posted online and on the iPad. Readers voted online, on the iPad, and during the 2014 American Academy of Neurology Annual Meeting in Philadelphia. The winning coauthors are Peter A. Kempster, from Melbourne, and Andrew J. Lees, from London. The runners-up are Anonymous (ending 1), Gerald Honch (ending 2), and Clifton Gooch (ending 4). The editors thank all participants and voters. The rule on page 662 indicates where the winning ending begins.

MSC

NASA Image and Video Library

1963-01-01

S63-00950 (1963) --- An aerial view of Site 1, the Manned Spacecraft Center, in 1963 during early construction. The view faces the southwest. Highway 528 is at the top of the picture. Second Street runs basically north and south on the right side of the image, to the right or west and running parallel to that avenue is a drainage ditch. Winding through the site a Houston Lighting and Power Co. canal crosses over the drainage ditch near the top of the frame. Twin bridges over the canal are pictured at upper left which were constructed to allow traffic to enter and leave through MSC's secondary gateway. The unfinished red structure to the right of center and roughly 100 yards south of the elevated water storage tank is the Central Heating and Cooling Plant. In the upper left quadrant of the frame, construction appears very far along on the Central Data Office.

Report of work done in the division of chemistry and physics, mainly during the fiscal year 1889-90

USGS Publications Warehouse

Clarke, Frank Wigglesworth

1891-01-01

This bulletin, like the bulletins issued in previous years and numbered 9, 27, 42, 55, 60, and 64, contains a partial record of work completed in the chemical and physical laboratories of the Survey Turing one tiscAl year. It represents, however, only a portion of the whole work done, for various investigations, begun during the year 1859—'90, are still unfinished; many analyses are reserved for publication in other reports; and certain of the larger researches, notably the physical studies of Dr. Barns, will appear in independent form as separate bulletins. In the annual reports of the Director of the Survey a tolerably complete summary of the work done in the Division of Chemistry and Physics is always given, and such summaries, taken in connection with these bulletins, convey.a fair idea of the amount of ground actually covered.

Confieso que Divulgo. Reflexiones y Experiencias de una Astrofísica

NASA Astrophysics Data System (ADS)

Rodríguez Hidalgo, I.

Este artículo presenta algunas reflexiones en torno a la popularización de la Ciencia, desarrolladas a lo largo de mi trayectoria profesional, un camino inacabado desde la intuición al oficio. Tras revisar las señas de identidad de la divulgación científica, se exponen ideas, experiencias y recursos, cribados por la práctica y su posterior análisis crítico. Se destacan las actividades relacionadas con la Astronomía, que se cuentan entre las más espectaculares y gratificantes. Confessions of a popularizer: This paper presents some author's thoughts about scientific outreach, developed along her professional path, an unfinished way from intuition to trade. First, identity signs of outreach are revised; then, ideas, experiences and resources, sifted by practice and further critical analysis, are reviewed. Activities related to Astronomy, being one of the most spectacular and rewarding, are remarked 1

Andreas Vesalius (1514-1564) - an unfinished life.

PubMed

Ambrose, Charles T

2014-01-01

The fame of Andreas Vesalius (1514-1564) rests on his anatomy text, De humani corporis fabrica, regarded as a seminal book in modern medicine. It was compiled while he taught anatomy at Padua, 1537-1543. Some of his findings challenged Galen's writings of the 2c AD, and caused De fabrica to be rejected immediately by classically trained anatomists. At age 29, Vesalius abandoned his studies and over the next two decades served as physician to Emperor Charles V of the Holy Roman Empire (HRE) and later to King Philip II of Spain in Madrid. In 1564, he sought to resume teaching anatomy in Padua, but release from royal service obliged him first to make a pilgrimage to Palestine. During the return voyage to Venice, he became ill and was put ashore alone on an Ionian island Zakynthos, where he died days later at age 50.

FrameD: A flexible program for quality check and gene prediction in prokaryotic genomes and noisy matured eukaryotic sequences.

PubMed

Schiex, Thomas; Gouzy, Jérôme; Moisan, Annick; de Oliveira, Yannick

2003-07-01

We describe FrameD, a program that predicts coding regions in prokaryotic and matured eukaryotic sequences. Initially targeted at gene prediction in bacterial GC rich genomes, the gene model used in FrameD also allows to predict genes in the presence of frameshifts and partially undetermined sequences which makes it also very suitable for gene prediction and frameshift correction in unfinished sequences such as EST and EST cluster sequences. Like recent eukaryotic gene prediction programs, FrameD also includes the ability to take into account protein similarity information both in its prediction and its graphical output. Its performances are evaluated on different bacterial genomes. The web site (http://genopole.toulouse.inra.fr/bioinfo/FrameD/FD) allows direct prediction, sequence correction and translation and the ability to learn new models for new organisms.

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.

PubMed

Gish, Robert G; Given, Bruce D; Lai, Ching-Lung; Locarnini, Stephen A; Lau, Johnson Y N; Lewis, David L; Schluep, Thomas

2015-09-01

The host immune system plays an important role in chronic hepatitis B (CHB), both in viral clearance and hepatocellular damage. Advances in our understanding of the natural history of the disease have led to redefining the major phases of infection, with the "high replicative, low inflammatory" phase now replacing what was formerly termed the "immune tolerant" phase, and the "nonreplicative phase" replacing what was formerly termed the "inactive carrier" phase. As opposed to the earlier view that HBV establishes chronic infection by exploiting the immaturity of the neonate's immune system, new findings on trained immunity show that the host is already somewhat "matured" following birth, and is actually very capable of responding immunologically, potentially altering future hepatitis B treatment strategies. While existing therapies are effective in reducing viral load and necroinflammation, often restoring the patient to near-normal health, they do not lead to a cure except in very rare cases and, in many patients, viremia rebounds after cessation of treatment. Researchers are now challenged to devise therapies that will eliminate infection, with a particular focus on eliminating the persistence of viral cccDNA in the nuclei of hepatocytes. In the context of chronic hepatitis B, new definitions of 'cure' are emerging, such as 'functional' and 'virological' cure, defined by stable off-therapy suppression of viremia and antigenemia, and the normalization of serum ALT and other liver-related laboratory tests. Continued advances in the understanding of the complex biology of chronic hepatitis B have resulted in the development of new, experimental therapies targeting viral and host factors and pathways previously not accessible to therapy, approaches which may lead to virological cures in the near term and functional cures upon long term follow-up. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B." Copyright © 2015 Elsevier B.V. All rights reserved.

Grain refinement of 7075Al alloy microstructures by inoculation with Al-Ti-B master alloy

NASA Astrophysics Data System (ADS)

Hotea, V.; Juhasz, J.; Cadar, F.

2017-05-01

This paper aims to bring some clarification on grain refinement and modification of high strength alloys used in aerospace technique. In this work it was taken into account 7075 Al alloy, and the melt treatment was carried out by placing in the form of master alloy wire ternary AlTiB the casting trough at 730°C. The morphology of the resulting microstructures was characterized by optical microscopy. Micrographs unfinished and finished with pre-alloy containing ternary Al5Ti1B evidence fine crystals, crystal containing no columnar structure and highlights the size of the dendrites, and intermetallic phases occurring at grain boundaries in Al-Zn-Mg-Cu alloy. It has been found that these intermetallic compounds are MgZn2 type. AlTiB master alloys finishing ensures a fine eutectic structure, which determines the properties of hardware and improving the mechanical properties of aluminum alloys used in aeronautical engineering.

Science friction: data, metadata, and collaboration.

PubMed

Edwards, Paul N; Mayernik, Matthew S; Batcheller, Archer L; Bowker, Geoffrey C; Borgman, Christine L

2011-10-01

When scientists from two or more disciplines work together on related problems, they often face what we call 'science friction'. As science becomes more data-driven, collaborative, and interdisciplinary, demand increases for interoperability among data, tools, and services. Metadata--usually viewed simply as 'data about data', describing objects such as books, journal articles, or datasets--serve key roles in interoperability. Yet we find that metadata may be a source of friction between scientific collaborators, impeding data sharing. We propose an alternative view of metadata, focusing on its role in an ephemeral process of scientific communication, rather than as an enduring outcome or product. We report examples of highly useful, yet ad hoc, incomplete, loosely structured, and mutable, descriptions of data found in our ethnographic studies of several large projects in the environmental sciences. Based on this evidence, we argue that while metadata products can be powerful resources, usually they must be supplemented with metadata processes. Metadata-as-process suggests the very large role of the ad hoc, the incomplete, and the unfinished in everyday scientific work.

Exploring Earth and the Solar System: Educational Outreach Through NASA's Space Place, SciJinks, and Climate Kids Websites

NASA Technical Reports Server (NTRS)

Meneses, Joseph Chistopher

2012-01-01

NASA's Space Place team publishes engaging content and creates an effective environment to inspire a young audience to dare mighty things. NASA uses the Space Place, Climate Kids, and SciJinks websites to cultivate interest among elementary-school-aged children in both science and technology. During my summer internship at Jet Propulsion Laboratory I used Adobe Flash and ActionScript 3 to develop content for the Space Place, Climate Kids, and SciJinks sites. In addition, I was involved in the development process for ongoing and new projects during my internship. My involvement allowed me to follow a project from concept to design, implementation, and release. I personally worked on three projects this summer, two of which are currently in deployment. The first is a scrambled letter-tile guessing game titled Solar System Scramble. The second, Butterfrog Mix-Up, is a rotating-tile puzzle game. The third project is a unfinished prototype for a maze game.

When the third is dead: memory, mourning, and witnessing in the aftermath of the holocaust.

PubMed

Gerson, Samuel

2009-12-01

The origins of psychoanalysis, as well as the concerns of our daily endeavors, center on engagement with the fate of the unbearable - be it wish, affect, or experience. In this paper, I explore psychological states and dynamics faced by survivors of genocide and their children in their struggle to sustain life in the midst of unremitting deadliness. Toward this continuous effort, I re-examine Freud's theoretical formulations concerning memory and mourning, elaborate André Green's concept of the 'Dead Mother', and introduce more recent work on the concepts of the 'third' and 'thirdness'. Throughout, my thoughts are informed by our clinical experience with the essential role of witnessing in sustaining life after massive trauma. I bring aspects of all these forms of knowing to reflections about a poem by Primo Levi entitled Unfinished business and to our own never finished business of avoiding denial while living in an age of genocide and under the aura of uncontained destructiveness.

Improving publication rates in a collaborative clinical trials research network.

PubMed

Archer, Stephanie Wilson; Carlo, Waldemar A; Truog, William E; Stevenson, David K; Van Meurs, Krisa P; Sánchez, Pablo J; Das, Abhik; Devaskar, Uday; Nelin, Leif D; Petrie Huitema, Carolyn M; Crawford, Margaret M; Higgins, Rosemary D

2016-10-01

Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Network's (NRN) publication policies for approving, reviewing, and tracking abstracts and papers work to combat these problems. In 2003, the NRN restricted investigators with unfinished manuscripts from proposing new ones and in 2010, urged authors to complete long-outstanding manuscripts. Data from 1991 to 2015 were analyzed to determine effectiveness of these policy changes. The NRN has achieved an overall publication rate of 78% for abstracts. For 1990-2002, of 137 abstracts presented, 43 (31%) were published within 2 years; for 2003-2009, after the manuscript completion policy was instituted, of 140 abstracts presented, 68 (49%) were published within 2 years. Following the effort in 2010, the rate increased to 64%. The NRN surpassed reported rates by developing a comprehensive process, holding investigators accountable and tracking abstracts from presentation to publication. Copyright © 2016. Published by Elsevier Inc.

Improving publication rates in a collaborative clinical trials research network

PubMed Central

Archer, Stephanie Wilson; Carlo, Waldemar A.; Truog, William E.; Stevenson, David K.; Van Meurs, Krisa P.; Sánchez, Pablo J.; Das, Abhik; Devaskar, Uday; Nelin, Leif D.; Petrie Huitema, Carolyn M.; Crawford, Margaret M.; Higgins, Rosemary D.

2016-01-01

Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Network’s (NRN) publication policies for approving, reviewing, and tracking abstracts and papers work to combat these problems. In 2003, the NRN restricted investigators with unfinished manuscripts from proposing new ones and in 2010, urged authors to complete long-outstanding manuscripts. Data from 1991 to 2015 were analyzed to determine effectiveness of these policy changes. The NRN has achieved an overall publication rate of 78% for abstracts. For 1990–2002, of 137 abstracts presented, 43 (31%) were published within 2 years; for 2003–2009, after the manuscript completion policy was instituted, of 140 abstracts presented, 68 (49%) were published within 2 years. Following the effort in 2010, the rate increased to 64%. The NRN surpassed reported rates by developing a comprehensive process, holding investigators accountable and tracking abstracts from presentation to publication. PMID:27423510

Nanosecond Neutron Analysis for the search of the lost Leonardo’s masterpiece, the Battle of Anghiari

NASA Astrophysics Data System (ADS)

Kuznetsov, A. V.; Gorshkov, I. Yu.; Evsenin, A. V.; Osetrov, O. I.; Vakhtin, D. N.; Cosentino, A.; Seracini, M.

2009-12-01

Between 1505 and 1506 Leonardo Da Vinci painted his masterpiece, the Battle of Anghiari, in Palazzo Vecchio's Hall of 500 in Florence. The unfinished mural remained visible until 1563, when architect Giorgio Vasari undertook a renovation of the Hall and all traces of the Battle of Anghiari were lost. However, scholarly interpretation and scientific evidence suggest that the mural could be on the eastern wall, hidden behind a brick wall built in 1563 by Vasari. This paper discusses the possibility of using NNA/APT (Nanosecond Neutron Analysis/Associated Particle Technique) to establish the presence of the masterpiece by identifying behind the Vasari's wall chemical elements from the gesso preparation layer of the mural and possibly from its pigments. This paper reports on the experiments run with a simple NNA/APT system and the Monte Carlo simulations that have been carried out in order to outline the experimental setup of an advanced NNA/APT able to detect and locate the tiny amount of gesso and pigments.

Unfinished business: the rebirth of the ALPO Lunar Dome Survey

NASA Astrophysics Data System (ADS)

Huddleston, Marvin W.

2004-05-01

The ALPO board of directors approved the revival of the Lunar Dome Survey during their annual board meeting in the summer of 2003. The initial LDS program was conceived by Harry Jamieson in the early 1960's and headed by him when the British Astronomical Assn. (BAA) was invited to join the program, which they did. The joint effort between the ALPO and BAA lunar sections lasted for approximately 14 years, ending officially around 1976 due to a decline in interest. The program was again revived in 1987 under the direction of Jim Phillips and lasted until the mid-1990's. All told, this program has been one of the longest running programs in the history of the Lunar Section of ALPO. The revived program will concentrate on cleaning up the existing catalog, classification and confirmation of the objects contained therein, and analysis of the database created in the process. It is hoped that, as in the past, much of the newly revived Lunar Dome Survey will be an international effort.

Persistence motives in irrational decisions to complete a boring task.

PubMed

Halkjelsvik, Torleif; Rise, Jostein

2015-01-01

We explored a novel task paradigm where participants from the online work marketplace Amazon Mechanical Turk were given the choice to quit or continue an unfinished boring task for identical economic rewards. In Studies 1a and 1b, about half the participants chose to continue (corresponding to an average of 55 and 35 cents in foregone earnings). Participants' self-reported reasons for continuing involved various types of persistence motives, reflecting a desire to persist or complete per se. Studies 2, 3a, 3b, and 3c ruled out the possibility that people continued because they enjoyed the task or believed there were additional rewards for continuing. Study 4 showed that the choice to quit/continue was associated with the manner in which the choice was presented (persistence test vs. decision-making test) and individual differences in dispositional persistence motives. The present data indicate that motivational forces independent of the focal reward may affect intertemporal decisions. © 2014 by the Society for Personality and Social Psychology, Inc.

The Unfinished Revolution: Einstein's revenge

NASA Astrophysics Data System (ADS)

Beichler, James

2007-04-01

Thomas Kuhn defined the characteristics of scientific revolutions based upon his knowledge of the first and second Scientific Revolutions. He concluded that such revolutions are the result of crises in science. However, he missed some important clues of how revolutions develop. Instead of looking at crises, we should look at the major trends in scientific and human thought prior to the revolutions and then we could gain a better understanding of how scientific revolutions emerge from the normal course of scientific evolution. Instead of defining revolutions by the crises that precede them, revolutions actually emerge from the successes of previous science while each revolution contains the seeds for the next revolution that follows. These seeds eventually grow into the crises that trigger revolutions. Under these circumstances, it can be shown that the space-time revolution of relativity theory was never completed, thus laying the foundations for the next revolution in science. Knowing this, we can determine if we have we already entered the pre-revolutionary period of the Third Scientific Revolution.

The construction of a model of the process of couples' forgiveness in emotion-focused therapy for couples.

PubMed

Meneses, Catalina Woldarsky; Greenberg, Leslie S

2011-10-01

This study explored how forgiveness unfolds in the context of emotion-focused couples therapy (EFT-C) in eight cases of women betrayed by their partners. Forgiveness was defined as a process involving the reduction in negative feelings and the giving out of undeserved compassion. This was measured by changes in the pre- and posttreatment scores on the Enright Forgiveness Inventory, the Unfinished Business Resolution Scale, and a single item directly asking respondents to indicate their degree of forgiveness. A task analysis was performed to rigorously track the steps leading to forgiveness using videotapes of therapy sessions for eight couples. The performance of the four couples who forgave were compared with each other and then contrasted with the performance of another four couples who did not reach forgiveness at the end of therapy. Based on these observations, a model of the process of forgiveness in EFT-C and a process rating system were developed. © 2011 American Association for Marriage and Family Therapy.

Speciman lists. Artisanal writing or natural historical paperwork?

PubMed

Pugliano, Valentina

2012-12-01

The epistolary exchanges of early modern natural history have long been of interest to historians of science, as they reflect the dynamic nature of the emergent discipline better than the printed volumes of natural history. Less attention, at least until recently, has been paid to the unfinished pieces, the cryptic marginalia, and the practical notes that more often than not accompanied letters. Lists of specimens sent or requested were among the new tools at the naturalist's disposal for dealing with a scientific world increasingly populated by objects. This essay seeks to reconstruct the genealogy of specimen lists by focusing on little-known apothecaries in northern Italy: the individuals traditionally held to be social counterparts to these modest strings of words. It seems that the operations at the back of the shop and the literature generated by the centuries-old drug and spice trades may have been a more defining influence on early modern naturalists than the humanist practices of indexing and commonplacing that were concurrently embraced by Italian studiosi.

Combining point context and dynamic time warping for online gesture recognition

NASA Astrophysics Data System (ADS)

Mao, Xia; Li, Chen

2017-05-01

Previous gesture recognition methods usually focused on recognizing gestures after the entire gesture sequences were obtained. However, in many practical applications, a system has to identify gestures before they end to give instant feedback. We present an online gesture recognition approach that can realize early recognition of unfinished gestures with low latency. First, a curvature buffer-based point context (CBPC) descriptor is proposed to extract the shape feature of a gesture trajectory. The CBPC descriptor is a complete descriptor with a simple computation, and thus has its superiority in online scenarios. Then, we introduce an online windowed dynamic time warping algorithm to realize online matching between the ongoing gesture and the template gestures. In the algorithm, computational complexity is effectively decreased by adding a sliding window to the accumulative distance matrix. Lastly, the experiments are conducted on the Australian sign language data set and the Kinect hand gesture (KHG) data set. Results show that the proposed method outperforms other state-of-the-art methods especially when gesture information is incomplete.

The unfinished business of primary biliary cirrhosis.

PubMed

Selmi, Carlo; Zuin, Massimo; Gershwin, M Eric

2008-09-01

In nearly every multifactorial human disease, there are three periods that characterize our understanding and definition. First, there is a period in which there is rapid accumulation of descriptive data. Second, there is a longer and slower period as information is obtained that redefines and expands basic and clinical knowledge that lacks the final and important area of understanding aetiology and therapeutic intervention. Third, which is much less common for most diseases, is the vigorous definition of pathobiology and treatment. These phases are well illustrated by our current understanding of primary biliary cirrhosis (PBC). The term PBC was first used nearly 60 years ago and for the first 40 or so years, the primary research efforts were directed at clinical definitions and pathology. Subsequently, with the advent of molecular biology, there began a rigorous dissection of the immune response and, in particular, a better understanding of anti-mitochondrial antibodies. These efforts have greatly helped in our understanding of not only the effector mechanisms of disease, but also the uniqueness of the primary target tissue, biliary epithelium. However, this research has still not led to successful translation for specific therapy.

The business process management software for successful quality management and organization: A case study from the University of Split School of Medicine.

PubMed

Sapunar, Damir; Grković, Ivica; Lukšić, Davor; Marušić, Matko

2016-05-01

Our aim was to describe a comprehensive model of internal quality management (QM) at a medical school founded on the business process analysis (BPA) software tool. BPA software tool was used as the core element for description of all working processes in our medical school, and subsequently the system served as the comprehensive model of internal QM. The quality management system at the University of Split School of Medicine included the documentation and analysis of all business processes within the School. The analysis revealed 80 weak points related to one or several business processes. A precise analysis of medical school business processes allows identification of unfinished, unclear and inadequate points in these processes, and subsequently the respective improvements and increase of the QM level and ultimately a rationalization of the institution's work. Our approach offers a potential reference model for development of common QM framework allowing a continuous quality control, i.e. the adjustments and adaptation to contemporary educational needs of medical students. Copyright © 2016 by Academy of Sciences and Arts of Bosnia and Herzegovina.

Port of Seattle breaks the brownfield gridlock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rapaport, D.

Initiatives in brownfields restoration--in which abandoned, contaminated industrial and commercial sites can be revitalized and returned to productive use--many times have been gridlocked by a core problem: how to achieve protective cleanup levels without bankrupting the cost bearers. Barriers to brownfields restoration include: remediation standards, set by regulatory agencies, that are difficult to achieve at complex sites; technical barriers that make it difficult to restore sites to pristine conditions; and liability and cost issues that discourage investors and lenders from properties struggling under an unfinished regulatory process. Each barrier affects the others, creating a maze that is easy to entermore » but difficult to escape. In many cases, money, time and expertise are squandered, and feelings of anger and frustration are vented. Fear of gridlock halts many brownfields projects before they begin. Previous site investigations conducted by property owners revealed that spills, leaks, drips and onsite waste disposal of organic and inorganic preservatives used in wood-treatment processes had contaminated the soil and groundwater. The most toxic contaminants were a group of carcinogenic polycyclic aromatic hydrocarbons, such as benzo(a)pyrene, pentachlorophenol and arsenic.« less

Low cost stable air electrode material for high temperature solid oxide electrolyte electrochemical cells

DOEpatents

Kuo, L.J.H.; Singh, P.; Ruka, R.J.; Vasilow, T.R.; Bratton, R.J.

1997-11-11

A low cost, lanthanide-substituted, dimensionally and thermally stable, gas permeable, electrically conductive, porous ceramic air electrode composition of lanthanide-substituted doped lanthanum manganite is provided which is used as the cathode in high temperature, solid oxide electrolyte fuel cells and generators. The air electrode composition of this invention has a much lower fabrication cost as a result of using a lower cost lanthanide mixture, either a natural mixture or an unfinished lanthanide concentrate obtained from a natural mixture subjected to incomplete purification, as the raw material in place of part or all of the higher cost individual lanthanum. The mixed lanthanide primarily contains a mixture of at least La, Ce, Pr, and Nd, or at least La, Ce, Pr, Nd and Sm in its lanthanide content, but can also include minor amounts of other lanthanides and trace impurities. The use of lanthanides in place of some or all of the lanthanum also increases the dimensional stability of the air electrode. This low cost air electrode can be fabricated as a cathode for use in high temperature, solid oxide fuel cells and generators. 4 figs.

Low cost stable air electrode material for high temperature solid oxide electrolyte electrochemical cells

DOEpatents

Kuo, Lewis J. H.; Singh, Prabhakar; Ruka, Roswell J.; Vasilow, Theodore R.; Bratton, Raymond J.

1997-01-01

A low cost, lanthanide-substituted, dimensionally and thermally stable, gas permeable, electrically conductive, porous ceramic air electrode composition of lanthanide-substituted doped lanthanum manganite is provided which is used as the cathode in high temperature, solid oxide electrolyte fuel cells and generators. The air electrode composition of this invention has a much lower fabrication cost as a result of using a lower cost lanthanide mixture, either a natural mixture or an unfinished lanthanide concentrate obtained from a natural mixture subjected to incomplete purification, as the raw material in place of part or all of the higher cost individual lanthanum. The mixed lanthanide primarily contains a mixture of at least La, Ce, Pr, and Nd, or at least La, Ce, Pr, Nd and Sm in its lanthanide content, but can also include minor amounts of other lanthanides and trace impurities. The use of lanthanides in place of some or all of the lanthanum also increases the dimensional stability of the air electrode. This low cost air electrode can be fabricated as a cathode for use in high temperature, solid oxide fuel cells and generators.

Backfilling with guarantees granted upon job submission.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leung, Vitus Joseph; Bunde, David P.; Lindsay, Alexander M.

2011-01-01

In this paper, we present scheduling algorithms that simultaneously support guaranteed starting times and favor jobs with system desired traits. To achieve the first of these goals, our algorithms keep a profile with potential starting times for every unfinished job and never move these starting times later, just as in Conservative Backfilling. To achieve the second, they exploit previously unrecognized flexibility in the handling of holes opened in this profile when jobs finish early. We find that, with one choice of job selection function, our algorithms can consistently yield a lower average waiting time than Conservative Backfilling while still providingmore » a guaranteed start time to each job as it arrives. In fact, in most cases, the algorithms give a lower average waiting time than the more aggressive EASY backfilling algorithm, which does not provide guaranteed start times. Alternately, with a different choice of job selection function, our algorithms can focus the benefit on the widest submitted jobs, the reason for the existence of parallel systems. In this case, these jobs experience significantly lower waiting time than Conservative Backfilling with minimal impact on other jobs.« less

A sampling method to determine insecticide residues on surfaces and its application to food-handling establishments.

PubMed

Leidy, R B; Wright, C G; Dupree, H E

1987-07-01

Known amounts of acephate, chlorpyrifos, and diazinon were applied to Formica, unfinished plywood, stainless steel, and vinyl tile. Cotton-ball and dental wick materials were dipped in 2-propanol and "swiped" over the treated surface area two time. More acephate was found on the second swipe compared to the first from vinyl tile, similar amounts on both swipes from plywood, and less on the second swipe from formica and stainless steel. The ratio of chlorpyrifos on Swipe 1 compared to Swipe 2 found with cotton-ball on both formica and stainless steel surfaces was equivalent (6:1), but a considerable difference was seen when two dental wick swipes were used. Residues of diazinon removed from formica and stainless steel were equivalent, regardless of the swiping material used. Residues of chlorpyrifos were detected by taking swipes of surfaces in two restaurants and a supermarket up to 6 mo after a prescribed application by a commercial pest control firm. The data show that measurable amounts of chloropyrifos can be detected on surfaces not treated with the insecticide for at least 6 mo.

Propping up pharma's (natural) neoliberal phallic man: pharmaceutical representations of the ideal sexuopharmaceutical user.

PubMed

Gurevich, Maria; Leedham, Usra; Brown-Bowers, Amy; Cormier, Nicole; Mercer, Zara

2017-04-01

Contemporary social theorists emphasise the cultural quest for authenticity under conditions of increasing artificiality. Within this context, the body is commonly treated as an 'unfinished' surface requiring ongoing transformation to fulfil identity obligations. In this paper, we examine one such identity authentication project in the form of marketing of men's sexuopharmaceuticals. We use online pharmaceutical advertising for four approved sexuopharmaceuticals (Viagra, Cialis, STAXYN and Stendra) to describe the ideal neoliberal consumer. These campaigns underscore the robust role of pharmaceuticals in sexual authentication projects undergirded by neoliberal consumerist and aspirationalist ideals. Penile dependability as a luxury consumerist project reinvigorates traditional sexual (masculine) authentication as yoked to phallic control, by repackaging sexual enhancement medication use as a neoliberal beacon of aspirational achievements. The ideal targeted user is increasingly younger, and consumption of sexuopharmaceuticals is represented as achieving elite status and exclusive pleasures; masculine authenticity and choice; progressive relationships and a contemporary urban, fast-paced life; and a prepared yet spontaneous romantic sexuality. Women are also increasingly used in promotional materials directed at men; their responsibility centres on coaching and coaxing potential users.

Whose interests and under whose control?: Interest convergence in science-focused school-community collaborations

NASA Astrophysics Data System (ADS)

Morrison, Deb

2018-03-01

In this dialogue with Monica Ridgeway and Randy Yerrick's Whose banner are we waving?: exploring STEM partnerships for marginalized urban youth, I engage the critical race theory (CRT) tenet of interest convergence. I first expand Derrick Bell's (1980) initial statement of interest convergence with subsequent scholarly work in this area. I then explore ways CRT in general and interest convergence specifically have been applied in the field of education. Using this framing, I examine how interest convergence may be shed new insights into Monica Ridgeway and Randy Yerrick's study. For example, the tenet of interest convergence is used to frame why it was beneficial for the White artist, Jacob, and the Achievement Scholars to collaborate in the service-learning mural. Then the idea of interest divergence is brought into explore the ways in which Jacob benefitted from his participation in the service learning project while the Achievement Scholars were left with an unfinished project which they had to problem solve. To conclude, I provide future directions for the application of interest convergence and divergence to issues facing science education.

The Asian monsoon over the past 640,000 years and ice age terminations.

PubMed

Cheng, Hai; Edwards, R Lawrence; Sinha, Ashish; Spötl, Christoph; Yi, Liang; Chen, Shitao; Kelly, Megan; Kathayat, Gayatri; Wang, Xianfeng; Li, Xianglei; Kong, Xinggong; Wang, Yongjin; Ning, Youfeng; Zhang, Haiwei

2016-06-30

Oxygen isotope records from Chinese caves characterize changes in both the Asian monsoon and global climate. Here, using our new speleothem data, we extend the Chinese record to cover the full uranium/thorium dating range, that is, the past 640,000 years. The record's length and temporal precision allow us to test the idea that insolation changes caused by the Earth's precession drove the terminations of each of the last seven ice ages as well as the millennia-long intervals of reduced monsoon rainfall associated with each of the terminations. On the basis of our record's timing, the terminations are separated by four or five precession cycles, supporting the idea that the '100,000-year' ice age cycle is an average of discrete numbers of precession cycles. Furthermore, the suborbital component of monsoon rainfall variability exhibits power in both the precession and obliquity bands, and is nearly in anti-phase with summer boreal insolation. These observations indicate that insolation, in part, sets the pace of the occurrence of millennial-scale events, including those associated with terminations and 'unfinished terminations'.

Overcoming the Newtonian paradigm: the unfinished project of theoretical biology from a Schellingian perspective.

PubMed

Gare, Arran

2013-09-01

Defending Robert Rosen's claim that in every confrontation between physics and biology it is physics that has always had to give ground, it is shown that many of the most important advances in mathematics and physics over the last two centuries have followed from Schelling's demand for a new physics that could make the emergence of life intelligible. Consequently, while reductionism prevails in biology, many biophysicists are resolutely anti-reductionist. This history is used to identify and defend a fragmented but progressive tradition of anti-reductionist biomathematics. It is shown that the mathematico-physico-chemical morphology research program, the biosemiotics movement, and the relational biology of Rosen, although they have developed independently of each other, are built on and advance this anti-reductionist tradition of thought. It is suggested that understanding this history and its relationship to the broader history of post-Newtonian science could provide guidance for and justify both the integration of these strands and radically new work in post-reductionist biomathematics. Copyright © 2013 Elsevier Ltd. All rights reserved.

Developing a gate-array capability at a research and development laboratory

NASA Astrophysics Data System (ADS)

Balch, J. W.; Current, K. W.; Magnuson, W. G., Jr.; Pocha, M. D.

1983-03-01

Experiences in developing a gate array capability for low volume applications in a research and development (R and D) laboratory are described. By purchasing unfinished wafers and doing the customization steps in-house. Turnaround time was shortened to as little as one week and the direct costs reduced to as low as $5K per design. Designs generally require fast turnaround (a few weeks to a few months) and very low volumes (1 to 25). Design costs must be kept at a minimum. After reviewing available commercial gate array design and fabrication services, it was determined that objectives would best be met by using existing internal integrated circuit fabrication facilities, the COMPUTERVISION interactive graphics layout system, and extensive computational capabilities. The reasons and the approach taken for; selection for a particular gate array wafer, adapting a particular logic simulation program, and how layout aids were enhanced are discussed. Testing of the customized chips is described. The content, schedule, and results of the internal gate array course recently completed are discussed. Finally, problem areas and near term plans are presented.

The Philosophy of Science and Technology in China: Political and Ideological Influences

NASA Astrophysics Data System (ADS)

Guo, Yuanlin

2014-09-01

In China, the philosophy of science and technology (PST) is derived from "Dialectics of Nature" (DN), which is based on Engels' unfinished book Dialektik der Natur. DN as a political ideology provides political guidance for scientists and engineers. Therefore, since 1981, "Introduction to Dialectics of Nature" (IDN) has been an obligatory course for master's degree students who study natural science or technology. In 1987, DN was renamed PST by the Chinese government in order to communicate and do research. The IDN teachers constitute most of the scholars who research PST. Nowadays, in China, PST includes philosophy of nature, philosophy of science, philosophy of technology, sociology of science, sociology of technology, "science, technology and society," history of science, history of technology, management of science, and management of technology due to having too many IDN teachers. In fact, it is neither a branch of philosophy, nor a subject. The number of the IDN teachers has been increasing since 1981, which makes PST a miscellaneous collection of many branches or subjects. Finally, PST is facing two new challenges: the reduction of IDN and academic corruption.

Nucleic acid polymers: Broad spectrum antiviral activity, antiviral mechanisms and optimization for the treatment of hepatitis B and hepatitis D infection.

PubMed

Vaillant, Andrew

2016-09-01

Antiviral polymers are a well-studied class of broad spectrum viral attachment/entry inhibitors whose activity increases with polymer length and with increased amphipathic (hydrophobic) character. The newest members of this class of compounds are nucleic acid polymers whose activity is derived from the sequence independent properties of phosphorothioated oligonucleotides as amphipathic polymers. Although the antiviral mechanisms and broad spectrum antiviral activity of nucleic acid polymers mirror the functionality of other members of this class, they exert in addition a unique post entry activity in hepatitis B infection which inhibits the release of HBsAg from infected hepatocytes. This review provides a general overview of the antiviral polymer class with a focus on nucleic acid polymers and their development as therapeutic agents for the treatment of hepatitis B/hepatitis D. This article forms part of a symposium in Antiviral Research on ''An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B.''. Copyright © 2016 The Author. Published by Elsevier B.V. All rights reserved.

Health promotion and health systems: some unfinished business.

PubMed

Ziglio, Erio; Simpson, Sarah; Tsouros, Agis

2011-12-01

One of the five action domains in the Ottawa Charter was Reorienting Health Services. In this paper, we reflect on why progress in this domain has been somewhat lethargic, particularly compared with some of the other action domains, and why now it is important to renew our commitment to this domain. Reorienting health services has been largely overlooked and opportunities missed, although good exceptions do exist. The occasion of the 25th anniversary of the Ottawa Charter represents an important opportunity for health promotion to: (i) renew its active voice in current policy debate and action and (ii) enhance achievements made to date by improving our efforts to advocate, enable and mediate for the reorientation of health services and systems. We outline six steps to reactivate and invest more in this action domain so as to be in a better position to promote health equitably and sustainably in today's fast changing world. Though our experience is mainly based in the European context, we hope that our reflections will be of some value to countries outside of this region.

[E. M. Jellinek's silenced and silencing transgenerational story].

PubMed

Kelemen, Gábor; Márk, Mónika

2013-01-01

Jellinek is a kind of archetypal character for future generations in the field of addiction studies. His implosion in the arena of alcoholism around the age of 50 was an unexpected challenge to medical science. We know very little about his own role models giving an intellectual and moral compass to his pragmatic creativity. More than 30 years has passed since Jellinek's death when an American sociologist Ron Roizen started unearthing his silent story. Roizen discerned that there are a lot of unsaid and muted issues in his personal Hungarian past. Our paper, based on the authors' research in Hungarian archives and other sources reveals that not just Jellinek's personal but his transgenerational narrative has been not-yet-said. This silenced and silencing history appears an unfinished business of acculturation of the family, which started prior to four generations. Authors have been concluding that the issue of religious conversion is a critical point in the process of acculturation. They examine the counter move of loyalty to family values and driving force of assimilation making their story unspeakable.

Desktop microsimulation: a tool to improve efficiency in the medical office practice.

PubMed

Montgomery, James B; Linville, Beth A; Slonim, Anthony D

2013-01-01

Because the economic crisis in the United States continues to have an impact on healthcare organizations, industry leaders must optimize their decision making. Discrete-event computer simulation is a quality tool with a demonstrated track record of improving the precision of analysis for process redesign. However, the use of simulation to consolidate practices and design efficiencies into an unfinished medical office building was a unique task. A discrete-event computer simulation package was used to model the operations and forecast future results for four orthopedic surgery practices. The scenarios were created to allow an evaluation of the impact of process change on the output variables of exam room utilization, patient queue size, and staff utilization. The model helped with decisions regarding space allocation and efficient exam room use by demonstrating the impact of process changes in patient queues at check-in/out, x-ray, and cast room locations when compared to the status quo model. The analysis impacted decisions on facility layout, patient flow, and staff functions in this newly consolidated practice. Simulation was found to be a useful tool for process redesign and decision making even prior to building occupancy. © 2011 National Association for Healthcare Quality.

Stillbirths: progress and unfinished business.

PubMed

Frøen, J Frederik; Friberg, Ingrid K; Lawn, Joy E; Bhutta, Zulfiqar A; Pattinson, Robert C; Allanson, Emma R; Flenady, Vicki; McClure, Elizabeth M; Franco, Lynne; Goldenberg, Robert L; Kinney, Mary V; Leisher, Susannah Hopkins; Pitt, Catherine; Islam, Monir; Khera, Ajay; Dhaliwal, Lakhbir; Aggarwal, Neelam; Raina, Neena; Temmerman, Marleen

2016-02-06

This first paper of the Lancet Series on ending preventable stillbirths reviews progress in essential areas, identified in the 2011 call to action for stillbirth prevention, to inform the integrated post-2015 agenda for maternal and newborn health. Worldwide attention to babies who die in stillbirth is rapidly increasing, from integration within the new Global Strategy for Women's, Children's and Adolescents' Health, to country policies inspired by the Every Newborn Action Plan. Supportive new guidance and metrics including stillbirth as a core health indicator and measure of quality of care are emerging. Prenatal health is a crucial biological foundation to life-long health. A key priority is to integrate action for prenatal health within the continuum of care for maternal and newborn health. Still, specific actions for stillbirths are needed for advocacy, policy formulation, monitoring, and research, including improvement in the dearth of data for effective coverage of proven interventions for prenatal survival. Strong leadership is needed worldwide and in countries. Institutions with a mandate to lead global efforts for mothers and their babies must assert their leadership to reduce stillbirths by promoting healthy and safe pregnancies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Self-Reported Stickiness of Mind-Wandering Affects Task Performance

PubMed Central

van Vugt, Marieke K.; Broers, Nico

2016-01-01

When asked to perform a certain task, we typically spend a decent amount of time thinking thoughts unrelated to that task–a phenomenon referred to as “mind-wandering.” It is thought that this mind-wandering is driven at least in part by our unfinished goals and concerns. Previous studies have shown that just after presenting a participant with their own concerns, their reports of task-unrelated thinking increased somewhat. However, effects of these concerns on task performance were somewhat inconsistent. In this study we take the opposite approach, and examine whether task performance depends on the self-reported thought content. Specifically, a particularly intriguing aspect of mind-wandering that has hitherto received little attention is the difficulty of disengaging from it, in other words, the “stickiness” of the thoughts. While presenting participants with their own concerns was not associated with clear effects on task performance, we showed that the reports of off-task thinking and variability of response times increased with the amount of self-reported stickiness of thoughts. This suggests that the stickiness of mind-wandering is a relevant variable, and participants are able to meaningfully report on it. PMID:27242636

The first eukaryote cell: an unfinished history of contestation.

PubMed

O'Malley, Maureen A

2010-09-01

The eukaryote cell is one of the most radical innovations in the history of life, and the circumstances of its emergence are still deeply contested. This paper will outline the recent history of attempts to reveal these origins, with special attention to the argumentative strategies used to support claims about the first eukaryote cell. I will focus on two general models of eukaryogenesis: the phagotrophy model and the syntrophy model. As their labels indicate, they are based on claims about metabolic relationships. The first foregrounds the ability to consume other organisms; the second the ability to enter into symbiotic metabolic arrangements. More importantly, however, the first model argues for the autogenous or self-generated origins of the eukaryote cell, and the second for its exogenous or externally generated origins. Framing cell evolution this way leads each model to assert different priorities in regard to cell-biological versus molecular evidence, cellular versus environmental influences, plausibility versus evolutionary probability, and irreducibility versus the continuity of cell types. My examination of these issues will conclude with broader reflections on the implications of eukaryogenesis studies for a philosophical understanding of scientific contestation. Copyright © 2010 Elsevier Ltd. All rights reserved.

Hydrogeology and historical assessment of a classic sequential-land use landfill site, Illinois, U.S.A.

NASA Astrophysics Data System (ADS)

Booth, Colin J.; Vagt, Peter J.

1990-05-01

The Blackwell site in northeastern Illinois was a classic sequential-use project combining land reclamation, a sanitary landfill, and a recreational park. This paper adds a recent assessment of leachate generation and groundwater contamination to the site's unfinished record. Hydrogeological studies show that (1) the landfill sits astride an outwash aquifer and a till mound, which are separated from an underlying dolomite aquifer by a thin, silty till; (2) leachate leaks from the landfill at an estimated average rate between 48 and 78 m3/d; (3) the resultant contaminant plume is virtually stagnant in the till but rapidly diluted in the outwash aquifer, so that no off-site contamination is detected; (4) trace VOC levels in the dolomite probably indicate that contaminants have migrated there from the landfill-derived plume in the outwash. Deviations from the original landfill concepts included elimination of a leachate collection system, increased landfill size, local absence of a clay liner, and partial use of nonclay cover. The hydrogeological setting was unsuitable for the landfill as constructed, indicating the importance of detailed geological consideration in landfill and land-use planning.

Trauma, forgiveness and the witnessing dance: making public spaces intimate.

PubMed

Gobodo-Madikizela, Pumla

2008-04-01

In this paper I explore the concept of forgiveness as a response to gross human rights violations. I present a conceptual examination of the effects of massive trauma in relation to what I refer to as the 'unfinished business' of trauma. Using a psychoanalytic framework, I consider the process of 'bearing witness' about trauma and examine how this process opens up the possibility of reciprocal expressions of empathy between victim and perpetrator. I then argue that, in this context of trauma testimony and witnessing, empathy is essential for the development of remorse on the part of perpetrators, and of forgiveness on the part of victims. Using a case study from South Africa's Truth and Reconciliation Commission (TRC) I clarify the relationship between empathy and forgiveness, and show how the restorative model of the TRC can open up an ethical space and create the possibility of transformation for victims, perpetrators and bystanders. In my conclusion I suggest that forgiveness in politics is the only action that holds promise for the repair of brokenness in post-conflict societies, particularly if, as in South Africa, victims have to live together with perpetrators and beneficiaries in the same country.

New Tool Creates a Big Stir

NASA Technical Reports Server (NTRS)

2001-01-01

A new self-adjusting, retractable pin tool for friction stir welding is now used in the manufacturing of components for NASA Space Shuttles. Friction stir welding is a process that makes straight-line welds without bringing the parent material to a liquid state. This is accomplished through high-speed rotation, which generates frictional heat between the welding tool and the piece being welded. This heat causes the material to soften to the point of plasticity without allowing it to melt. The plasticized material is then transferred from the front edge of the welding tool to the trail edge, where it joins the pieces being welded. However, a major flaw of this method is its reliance on a single-piece pin tool. The weld is left unfinished and a hole remains where the pin was inserted. The hole must be covered with a rivet in order to preserve the integrity of the weld. The NASA-developed pin tool, however, eliminates the need for this finishing step, as its retraction allows continuous rewelding at lesser depths, until the hole is completely closed. With this NASA technology, welding of higher strength alloys, as well as non-planer and variable thickness structures can be achieved.

Visual cognition

PubMed Central

Cavanagh, Patrick

2011-01-01

Visual cognition, high-level vision, mid-level vision and top-down processing all refer to decision-based scene analyses that combine prior knowledge with retinal input to generate representations. The label “visual cognition” is little used at present, but research and experiments on mid- and high-level, inference-based vision have flourished, becoming in the 21st century a significant, if often understated part, of current vision research. How does visual cognition work? What are its moving parts? This paper reviews the origins and architecture of visual cognition and briefly describes some work in the areas of routines, attention, surfaces, objects, and events (motion, causality, and agency). Most vision scientists avoid being too explicit when presenting concepts about visual cognition, having learned that explicit models invite easy criticism. What we see in the literature is ample evidence for visual cognition, but few or only cautious attempts to detail how it might work. This is the great unfinished business of vision research: at some point we will be done with characterizing how the visual system measures the world and we will have to return to the question of how vision constructs models of objects, surfaces, scenes, and events. PMID:21329719

Reducing assembly complexity of microbial genomes with single-molecule sequencing.

PubMed

Koren, Sergey; Harhay, Gregory P; Smith, Timothy P L; Bono, James L; Harhay, Dayna M; Mcvey, Scott D; Radune, Diana; Bergman, Nicholas H; Phillippy, Adam M

2013-01-01

The short reads output by first- and second-generation DNA sequencing instruments cannot completely reconstruct microbial chromosomes. Therefore, most genomes have been left unfinished due to the significant resources required to manually close gaps in draft assemblies. Third-generation, single-molecule sequencing addresses this problem by greatly increasing sequencing read length, which simplifies the assembly problem. To measure the benefit of single-molecule sequencing on microbial genome assembly, we sequenced and assembled the genomes of six bacteria and analyzed the repeat complexity of 2,267 complete bacteria and archaea. Our results indicate that the majority of known bacterial and archaeal genomes can be assembled without gaps, at finished-grade quality, using a single PacBio RS sequencing library. These single-library assemblies are also more accurate than typical short-read assemblies and hybrid assemblies of short and long reads. Automated assembly of long, single-molecule sequencing data reduces the cost of microbial finishing to $1,000 for most genomes, and future advances in this technology are expected to drive the cost lower. This is expected to increase the number of completed genomes, improve the quality of microbial genome databases, and enable high-fidelity, population-scale studies of pan-genomes and chromosomal organization.

The Iceman's last weeks

NASA Astrophysics Data System (ADS)

Spindler, Konrad

1994-06-01

The author presents the archaeological, botanical and anatomical of medical evidence relating to the events of the last few days of the Iceman's life. The unfinished arrows and the half-completed bow indicate that he had lost his weapons and was in the process of re-arming himself. The quiver and the two primed arrows show clear signs of damage that has been proved to originate from before entombment in the ice of Hauslabjoch. An intravital series of fractured ribs and atrophic changes to the humerus on the same side of the body are also indicative of a violent conflict. The presence of threshing and winnowing fragments proves that, shortly before his death, the Iceman spent some time in a human settlement in which the grain crop was threshed. The theory is therefore proposed that shortly before his death the Iceman suffered some personal catastrophe involving damage to his possessions and physical injury. He fled in the direction of the inner Ötz Valley, a region of high alpine pastures he may have been familiar with from summer transhumance. Just beyond the ridge of the main Alpine chain he was caught by a sudden fall in temperature and snowfall, which he did not survive.

An FMS Dynamic Production Scheduling Algorithm Considering Cutting Tool Failure and Cutting Tool Life

NASA Astrophysics Data System (ADS)

Setiawan, A.; Wangsaputra, R.; Martawirya, Y. Y.; Halim, A. H.

2016-02-01

This paper deals with Flexible Manufacturing System (FMS) production rescheduling due to unavailability of cutting tools caused either of cutting tool failure or life time limit. The FMS consists of parallel identical machines integrated with an automatic material handling system and it runs fully automatically. Each machine has a same cutting tool configuration that consists of different geometrical cutting tool types on each tool magazine. The job usually takes two stages. Each stage has sequential operations allocated to machines considering the cutting tool life. In the real situation, the cutting tool can fail before the cutting tool life is reached. The objective in this paper is to develop a dynamic scheduling algorithm when a cutting tool is broken during unmanned and a rescheduling needed. The algorithm consists of four steps. The first step is generating initial schedule, the second step is determination the cutting tool failure time, the third step is determination of system status at cutting tool failure time and the fourth step is the rescheduling for unfinished jobs. The approaches to solve the problem are complete-reactive scheduling and robust-proactive scheduling. The new schedules result differences starting time and completion time of each operations from the initial schedule.

Unfinished business: efforts to define dual-use research of bioterrorism concern.

PubMed

Zmorzynska, Anna; Suk, Jonathan E; Biederbick, Walter; Maidhof, Heinrich; Sasse, Julia; Semenza, Jan C; Hunger, Iris

2011-12-01

Biotechnological research poses a special security problem because of the duality between beneficial use and misuse. In order to find a balance between regulating potentially dangerous research and assuring scientific advancement, a number of assessments have tried to define which types of research are especially open to misuse and should therefore be considered dual-use research of special concern requiring rigorous oversight. So far, there has been no common understanding of what such activities are. Here we present a review of 27 assessments focusing on biological dual-use issues published between 1997 and 2008. Dual-use research activities identified by these assessments as being of special concern were compiled and compared. Moreover, from these 27 assessments, the primary research publications explicitly identified as examples of concerning research activities were extracted and analyzed. We extracted a core list of 11 activities of special concern and show that this list does not match with the reasons why primary research publications were identified as being of special concern. Additionally, we note that the 11 activities identified are not easily conducted or replicated, and therefore the likelihood of their being used in a high-tech mass casualty bioterrorism event should be reevaluated. © Mary Ann Liebert, Inc.

Drug packaging in 2014: authorities should direct more efforts towards medication safety.

PubMed

2015-05-01

In 2014, Prescrire examined the packaging quality of about 250 drugs. A few advances stand out, mainly involving recent drugs, but on the whole, the situation is worrisome in terms of medication safety. Although pharmaceutical companies and drug regulatory agencies seem to be taking more account of the risk of accidental poisoning in children, the level of protection remains low overall in the absence of stringent measures on the part of the authorities. New drugs too often have poor-quality or even dangerous packaging at the time of their market introduction. And the packaging quality of older drugs is disturbing. Pharmaceutical companies no longer invest in the packaging of these products, and agencies often fail to take advantage of the opportunities provided by their reassessment to improve the situation. The inappropriate labelling of certain injectable drugs remains a source of medication errors, sometimes resulting in very serious consequences. In 2014, signs of progress in the packaging of several drugs show that its role in medication safety is better appreciated. But the persistence of dangers in the pharmaceuticals market, created by "unfinished", overly complex or poor-quality packaging, raises the question of the responsibility of pharmaceutical companies and agencies for past and present accidents.

Shifts in global immunisation goals (1984-2004): unfinished agendas and mixed results.

PubMed

Hardon, Anita; Blume, Stuart

2005-01-01

The turn of the millennium has been marked by a large-scale mobilisation of resources for immunisation programmes in developing countries. The resources have been generated by public and private sector parties collaborating in the Global Alliance for Vaccines and Immunization (GAVI). GAVI was formed in response to deteriorating immunisation coverage rates occurring in the late 1990s. GAVI is the latest in a line of vaccine initiatives, which have operated over the past 20 years. This article reviews the five most important global immunisation initiatives that have taken place over those past 20 years. It analyses their origins, shifts in global immunisation goals, identifies key actors, assesses the initiatives' capacity to mobilise resources and increase immunisation coverage, and points to possible unintended effects of the initiatives. The study argues that shifts in global immunisation goals lead to fragmentation in the implementation of vaccine programmes at the local level in developing countries. It also suggests that global actors involved in the formulation of these initiatives appear to miss opportunities to build on past experiences and fail to learn from previous mistakes. This raises questions about the initiatives' sustainability and relevance to the overall objective of preventing vaccine-preventable deaths.

Occupational exposure to Polycyclic Aromatic Hydrocarbons in wood dust

NASA Astrophysics Data System (ADS)

Huynh, C. K.; Schüpfer, P.; Boiteux, P.

2009-02-01

Sino-nasal cancer (SNC) represents approximately 3% of Oto-Rhino-Laryngology (ORL) cancers. Adenocarcinoma SNC is an acknowledged occupational disease affecting certain specialized workers such as joiners and cabinetmakers. The high proportion of woodworkers contracting a SNC, subjected to an estimated risk 50 to 100 times higher than that affecting the general population, has suggested various study paths to possible causes such as tannin in hardwood, formaldehyde in plywood and benzo(a)pyrene produced by wood when overheated by cutting tools. It is acknowledged that tannin does not cause cancer to workers exposed to tea dust. Apart from being an irritant, formaldehyde is also classified as carcinogenic. The path involving carcinogenic Polycyclic Aromatic Hydrocarbons (PAHs) emitted by overheated wood is attractive. In this study, we measured the particle size and PAHs content in dust emitted by the processing of wood in an experimental chamber, and in field situation. Quantification of 16 PAHs is carried out by capillary GC-ion trap Mass Spectrometric analysis (GC-MS). The materials tested are rough fir tree, oak, impregnated polyurethane (PU) oak. The wood dust contains carcinogenic PAHs at the level of μg.g-1 or ppm. During sanding operations, the PU varnish-impregnated wood produces 100 times more PAHs in dust than the unfinished wood.

[Sex education and prevention of sexual violence : Contributions to a differential-sensitive prevention of sexualised violence].

PubMed

Wazlawik, Martin; Christmann, Bernd; Dekker, Arne

2017-09-01

Prevention of sexual violence against children and adolescents obtains high priority in educational contexts. This is due to the massive (possible) psychosocial impacts of sexual victimization as well as to the considerable prevalence rates that are reported in current studies. Preventive approaches are predominantly native to violence prevention and sex education where they are characterized by independent lines of tradition and positions. This contribution outlines their empirically largely unexplained relation with a focus on the history and development of the discourses of sex education. Diverging disciplinary attempts of positioning towards the prevention of sexual violence reveal an area of conflict between sex-positive and preventive educational objectives. A primacy of preventive contents is seen to be threatening a comprehensive sex education that emphasizes the positive aspects of sexuality. On the other hand, its standards are opposed to excluding and to tabooing sexual violence as a topic. Yet unfinished is therefore the search for a "third way" that might transfer the opposites of both approaches into integrative educational concepts. Unsettled questions about possible contributions of sex education to the prevention of sexual violence, and especially to which extent they are sensitive to difference are discussed based on international research and the theory of sex education.

Gravitational Lensing: Einstein's unfinished symphony

NASA Astrophysics Data System (ADS)

Treu, Tommaso; Ellis, Richard S.

2015-01-01

Gravitational lensing - the deflection of light rays by gravitating matter - has become a major tool in the armoury of the modern cosmologist. Proposed nearly a hundred years ago as a key feature of Einstein's theory of general relativity, we trace the historical development since its verification at a solar eclipse in 1919. Einstein was apparently cautious about its practical utility and the subject lay dormant observationally for nearly 60 years. Nonetheless there has been rapid progress over the past twenty years. The technique allows astronomers to chart the distribution of dark matter on large and small scales thereby testing predictions of the standard cosmological model which assumes dark matter comprises a massive weakly-interacting particle. By measuring the distances and tracing the growth of dark matter structure over cosmic time, gravitational lensing also holds great promise in determining whether the dark energy, postulated to explain the accelerated cosmic expansion, is a vacuum energy density or a failure of general relativity on large scales. We illustrate the wide range of applications which harness the power of gravitational lensing, from searches for the earliest galaxies magnified by massive clusters to those for extrasolar planets which temporarily brighten a background star. We summarise the future prospects with dedicated ground and space-based facilities designed to exploit this remarkable physical phenomenon.

Improving Patient Safety: Avoiding Unread Imaging Exams in the National VA Enterprise Electronic Health Record.

PubMed

Bastawrous, Sarah; Carney, Benjamin

2017-06-01

In the current digital and filmless age of radiology, rates of unread radiology exams remain low, however, may still exist in unique environments. Veterans Affairs (VA) health care systems may experience higher rates of unread exams due to coexistence of Veterans Health Information Systems and Technology Architecture (VistA) imaging and commercial picture archiving and communication systems (PACS). The purpose of this patient safety initiative was to identify any unread exams and causes leading to unread exams. Following approval by departmental quality assurance committee, a comprehensive review was performed of all radiology exams within VistA imaging from July 1, 2009 to June 30, 2014 to identify unread radiology exams. Over the 5-year period, the total unread exam rate was calculated to be 0.17%, with the highest yearly unread exam rate of 0.25%. The leading majority of unread exam type was plain radiographs. Analysis revealed unfinished dictations, unassociated accession numbers, technologist errors, and inefficient radiologist work lists as top contributors to unread exams. Once unread radiology exams were discovered and the causes identified, valuable process changes were implemented within our department to ensure simultaneous tracking of all unread exams in VistA imaging as well as the commercial PACS.

Macro Social Flaws and Intervention's Unfinished Business: A Personal Note on Young People's Drug Use in Hong Kong.

PubMed

Cheung, Yuet W

2015-01-01

This paper traces how social, economic, and cultural changes in Hong Kong in the past five decades might have affected the pattern of illicit drug use among young people in Hong Kong. The prevalence of illicit drug use by young people had been very low before the 1990s, and like adult users, young users mostly used heroin. This pattern of drug use started to change in the late 1990s, when there was a sudden upsurge of drug use among young people, and psychoactive drugs such as ketamine quickly replaced heroin as the most popular drugs among them. An attempt is made to explain the new pattern of young people's drug use with respect to the changes of the social, economic and cultural conditions of Hong Kong since the 1960s, making use of Beck's risk society perspective and Parker's concept of normalization of recreational drug use. The identification of macro social flaws points to the need to address societal factors impeding successful interventions, which will involve reducing the blockage of upward mobility for young people, and providing them with the latest scientific knowledge of the physical and mental damages of ketamine and other psychoactive drugs for their better understanding of the risk of drug use.

The Hepatitis B Virus Ribonuclease H as a Drug Target

PubMed Central

Tavis, John E.; Lomonosova, Elena

2015-01-01

Chronic hepatitis B virus (HBV) infection is a leading cause of hepatitis, liver failure, and hepatocellular carcinoma. An outstanding vaccine is available; however the number of infections remains high. Current anti-HBV treatments with interferon α and nucleos(t)ide analogs clear the infection in only a small minority of patients, and either induce serious side-effects or are of very long duration. HBV is a small, enveloped DNA virus that replicates by reverse transcription via an RNA intermediate. The HBV ribonuclease H (RNaseH) is essential for viral replication, but it has not been exploited as a drug target. Recent low-throughput screening of compound classes with anti-Human Immunodeficiency Virus RNaseH activity led to identification of HBV RNaseH inhibitors in three different chemical families that block HBV replication. These inhibitors are promising candidates for development into new anti-HBV drugs. The RNaseH inhibitors may help improve treatment efficacy enough to clear the virus from the liver when used in combination with existing anti-HBV drugs and/or with other novel inhibitors under development. This article forms part of a symposium in Antiviral Research on “An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B.” PMID:25862291

A psychology of liberation for Central America: the unfinished work of Ignacio Martín-Baró (1942-1989).

PubMed

Gondra, José María

2013-01-01

On November 16, 1989 the world was shocked by the news of the assassination of six Jesuits at the campus of the Universidad Centro Americana José Simeón Cañas (UCA) in San Salvador, El Salvador. Among those murdered by government soldiers was Ignacio Martín-Baró, a PhD in social psychology from the University of Chicago who at that time was the Vice-Rector for Academic Affairs and Vice-President of the Interamerican Society of Psychology (SIP). Drawing on Martín-Baró's published writings and non-published academic papers and correspondence, this article traces the evolution of the Spanish-born Jesuit who became a leading authority among Latin American social psychologists. In particular, it analyzes his project of becoming a clinical psychologist under the influence of psychoanalysis, his critical social psychology aimed to "de-ideologize" the oppressed social classes of El Salvador, and his ultimate project of a psychology of liberation for Latin America. Martín-Baró's work came to a tragic end just when it began to bear fruit, but it stands as a testimony to a lifetime committed to the human values of democracy, social justice and service to society's poorest and most neglected.

Darbishire expands his vision of heredity from Mendelian genetics to inherited memory.

PubMed

Wood, Roger J

2015-10-01

The British biologist A.D. Darbishire (1879-1915) responded to the rediscovery in 1900 of Mendel's theory of heredity by testing it experimentally, first in Oxford, then in Manchester and London. He summarised his conclusions in a textbook 'Breeding and the Mendelian Discovery' (1911), in which he questioned whether Mendelism alone could explain all aspects of practical breeding experience. Already he had begun to think about an alternative theory to give greater emphasis to the widely held conviction among breeders regarding the inheritance of characteristics acquired during an individual's life. Redefining heredity in terms of a germ-plasm based biological memory, he used vocabulary drawn partly from sources outside conventional science, including the metaphysical/vitalistic writings of Samuel Butler and Henri Bergson. An evolving hereditary memory fitted well with the conception of breeding as a creative art aimed at greater economic efficiency. For evolution beyond human control he proposed a self-modifying process, claiming it to surpass in efficiency the chancy mechanism of natural selection proposed by Darwin. From his writings, including early chapters of an unfinished book entitled 'An Introduction to a Biology', we consider how he reached these concepts and how they relate to later advances in understanding the genome and the genetic programme. Copyright © 2015 Elsevier Ltd. All rights reserved.

[Incidence and causes of early end in awake surgery for language mapping not directly related to eloquence].

PubMed

Villalba, Gloria; Pacreu, Susana; Fernández-Candil, Juan Luis; León, Alba; Serrano, Laura; Conesa, Gerardo

2016-01-01

The incidence and causes that may lead to an early end (unfinished cortical/subcortical mapping) of awake surgery for language mapping are little known. A study was conducted on 41 patients with brain glioma located in the language area that had awake surgery under conscious sedation. Surgery was ended early in 6 patients. The causes were: tonic-clonic seizure (1), lack of cooperation due to fatigue/sleep (4), whether or not word articulation was involved, a decreased level of consciousness for ammonia encephalopathy that required endotracheal intubation (1). There are causes that could be expected and in some cases avoided. Tumour size, preoperative aphasia, valproate treatment, and type of anaesthesia used are variables to consider to avoid failure in awake surgery for language mapping. With these results, the following measures are proposed: l) If the tumour is large, perform surgery in two times to avoid fatigue, 2) if patient has a preoperative aphasia, do not use sedation during surgery to ensure that sleepiness does not cause worse word articulation, 3) if the patient is on valproate treatment, it is necessary to rule out the pre-operative symptoms that are not due to ammonia encephalopathy. Copyright © 2015 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

Chromium released from leather – I: exposure conditions that govern the release of chromium(III) and chromium(VI)

PubMed Central

Hedberg, Yolanda S; Lidén, Carola; Odnevall Wallinder, Inger

2015-01-01

Background Approximately 1–3% of the adult population in Europe is allergic to chromium (Cr). A new restriction in REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) based on the ISO 17075 standard has recently been adopted in the EU to limit Cr(VI) in consumer and occupational leather products. Objectives The aim of this study was to critically assess key experimental parameters in this standard on the release of Cr(III) and Cr(VI) and their relevance for skin exposure. Material and methods Four differently tanned, unfinished, leather samples were systematically investigated for their release of Cr(III) and Cr(VI) in relation to surface area, key exposure parameters, temperature, ultraviolet irradiation, and time. Results Although the total release of Cr was largely unaffected by all investigated parameters, except exposure duration and temperature, the Cr oxidation state was highly dynamic, with reduced amounts of released Cr(VI) with time, owing to the simultaneous release of reducing agents from the leather. Significantly more Cr(III) than Cr(VI) was released from the Cr-tanned leather for all conditions tested, and it continued to be released in artificial sweat up to at least 1 week of exposure. Conclusions Several parameters were identified that influenced the outcome of the ISO 17075 test. PMID:25653094

The evolution of child health programmes in developing countries: from targeting diseases to targeting people.

PubMed Central

Claeson, M.; Waldman, R. J.

2000-01-01

Mortality rates among children and the absolute number of children dying annually in developing countries have declined considerably over the past few decades. However, the gains made have not been distributed evenly: childhood mortality remains higher among poorer people and the gap between rich and poor has grown. Several poor countries, and some poorer regions within countries, have experienced a levelling off of or even an increase in childhood mortality over the past few years. Until now, two types of programmes--short-term, disease-specific initiatives and more general programmes of primary health care--have contributed to the decline in mortality. Both types of programme can contribute substantially to the strengthening of health systems and in enabling households and communities to improve their health care. In order for them to do so, and in order to complete the unfinished agenda of improving child health globally, new strategies are needed. On the one hand, greater emphasis should be placed on promoting those household behaviours that are not dependent on the performance of health systems. On the other hand, more attention should be paid to interventions that affect health at other stages of the life cycle while efforts that have been made to develop interventions that can be used during childhood continue. PMID:11100618

Use of RSS feeds for the implementation of clinical reminder.

PubMed

Chi, Wen-Chou; Wen, Chia-Hsien; Lin, Chih-Yu; Poon, Sek-Kwong; Huang, Shih-Che

2012-06-01

A computer-based reminder system can help physicians get right information and make right decisions in daily clinical work in time. This study presents a RSS-based Clinical Reminding System (RCRS) designed for reminding clinicians to deal with their varied unfinished clinical works. The RCRS was implemented in a hospital to automatically generate messages for every clinician on the basis of clinical information gathered from the hospital information system (HIS) and send them by RSS feed. In order to allow all physicians to participate in the project, the RCRS was integrated with the Computerized Physician Order Entry (COPE) system to provide messages whenever a clinician logs in the HIS; the connection on screen lets the clinician easily make some response. The system can help clinicians focus on patient care without keeping track of the schedule of clinical chores stored in various systems. Two physicians, also directors from Clinical Informatics Research & Development Center (CIRD) who were appointed as project leaders of the RCRS project who went through the entire development process were chosen as interviewees to obtain a preliminary evaluation of the system. The results show the "Information Content" of this system was suggested to be modified, and "Information Accuracy", "Formats", "Ease of use" and "Timeliness" of the system were appropriate to meet the system design purposes.

Automated Decisional Model for Optimum Economic Order Quantity Determination Using Price Regressive Rates

NASA Astrophysics Data System (ADS)

Roşu, M. M.; Tarbă, C. I.; Neagu, C.

2016-11-01

The current models for inventory management are complementary, but together they offer a large pallet of elements for solving complex problems of companies when wanting to establish the optimum economic order quantity for unfinished products, row of materials, goods etc. The main objective of this paper is to elaborate an automated decisional model for the calculus of the economic order quantity taking into account the price regressive rates for the total order quantity. This model has two main objectives: first, to determine the periodicity when to be done the order n or the quantity order q; second, to determine the levels of stock: lighting control, security stock etc. In this way we can provide the answer to two fundamental questions: How much must be ordered? When to Order? In the current practice, the business relationships with its suppliers are based on regressive rates for price. This means that suppliers may grant discounts, from a certain level of quantities ordered. Thus, the unit price of the products is a variable which depends on the order size. So, the most important element for choosing the optimum for the economic order quantity is the total cost for ordering and this cost depends on the following elements: the medium price per units, the stock cost, the ordering cost etc.

The Continuing Saga of the Marine Polyether Biotoxins

PubMed Central

Nicolaou, K. C.; Frederick, Michael O.; Aversa, Robert J.

2009-01-01

Lead-in Brevetoxin B emerged from the sea and into the laboratories of Nakanishi and Clardy who, in 1981, reported its magnificent and unprecedented structure. With its ladder-like fused polyether molecular architecture, potent toxicity, and fascinating voltage-sensitive sodium channel-based mechanism of action, it immediately captured the imagination of chemists around the world. Their synthetic escapades resulted in numerous new synthetic methods and strategies for the construction of cyclic ethers, and culminated in several impressive total syntheses of this imposing molecule and some of its equally challenging siblings that followed. Indeed, many more brevetoxin-type marine polyethers have been reported since 1981 with maitotoxin being not only the most complex and most toxic of the class, but also the largest non-polymeric natural product known to date. In this article, we begin with a brief history of these biotoxins and the phenomena that led to their isolation and highlight their biological properties and mechanism of action. We then review the chemical synthesis endeavors so far published in this long running saga, placing particular emphasis on the new synthetic methods and technologies discovered, developed and applied to their total syntheses over the last few decades. Finally, we conclude with a discussion of the, as yet unfinished, story of maitotoxin, and project into the future of this fascinating area of research. PMID:18763702

Music models aberrant rule decoding and reward valuation in dementia

PubMed Central

Clark, Camilla N; Golden, Hannah L; McCallion, Oliver; Nicholas, Jennifer M; Cohen, Miriam H; Slattery, Catherine F; Paterson, Ross W; Fletcher, Phillip D; Mummery, Catherine J; Rohrer, Jonathan D; Crutch, Sebastian J; Warren, Jason D

2018-01-01

Abstract Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterized. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia (FTD) syndromes and Alzheimer’s disease (AD) relative to healthy age-matched individuals. We created short melodies that were either harmonically resolved (‘finished’) or unresolved (‘unfinished’); the task was to classify each melody as finished or unfinished (rule processing) and rate its subjective pleasantness (reward valuation). Results were adjusted for elementary pitch and executive processing; neuroanatomical correlates were assessed using voxel-based morphometry. Relative to healthy older controls, patients with behavioural variant FTD showed impairments of both musical rule decoding and reward valuation, while patients with semantic dementia showed impaired reward valuation but intact rule decoding, patients with AD showed impaired rule decoding but intact reward valuation and patients with progressive non-fluent aphasia performed comparably to healthy controls. Grey matter associations with task performance were identified in anterior temporal, medial and lateral orbitofrontal cortices, previously implicated in computing diverse biological and non-biological rules and rewards. The processing of musical rules and reward distils cognitive and neuroanatomical mechanisms relevant to complex socio-emotional dysfunction in major dementias. PMID:29186630

Household Disposal of Pharmaceuticals as a Pathway for Aquatic Contamination in the United Kingdom

PubMed Central

Bound, Jonathan P.; Voulvoulis, Nikolaos

2005-01-01

Pharmaceuticals are produced and used in increasingly large volumes every year. With this growth comes concern about the fate and effects of these compounds in the environment. The discovery of pharmaceuticals in the aquatic environment has stimulated research in the last decade. A wide range of pharmaceuticals has been found in fresh and marine waters, and it has recently been shown that even in small quantities, some of these compounds have the potential to cause harm to aquatic life. The primary pathway into the environment is the use and disposal of medicines; although much of the research in the area currently focuses on the removal of pharmaceuticals during sewage treatment processes, disposal via household waste might be a significant pathway requiring further research. To investigate the household disposal of unused and expired pharmaceuticals as a source of pharmaceutical compounds in the environment, we carried out a survey and interviewed members of 400 households, predominantly from southeastern England. We used the information on when and how they disposed of unfinished pharmaceuticals to construct a conceptual model to assess the pathways of human pharmaceuticals into the environment. The model demonstrated that disposal of unused pharmaceuticals, either by household waste or via the sink or toilet, may be a prominent route that requires greater attention. PMID:16330351

[Social pain].

PubMed

Shimoyama, Naohito; Shimoyama, Megumi

2011-09-01

This chapter focuses on what social pain is and how it should be managed. In order to understand social pain in a cancer patient, it is necessary to recognize the change in the patient's daily life after the diagnosis of cancer. Because the degree of suffering and the relationships with family members and the people he or she worked with differ from patient to patient, it is important to note that the context of social pain is different in each patient. Five points shown below are essential in managing social pain. 1. Economical suffering may be alleviated by utilization of the social security system while taking into account each patient's standard of living. 2. Burdens on family members should be lessened, such as by not having them stay at the patient's bedside every day and letting them go home occasionally. 3. The normal patterns of communication, support, and conflict in the family should be identified, and the extent to which they have been disrupted by the illness should be assessed. 4. It is important to understand the ethnic, cultural, and religious background of the patient and the potential impact of their influence on the individual and the illness. 5. Practical or emotional unfinished business that the patient has needs to be identified, and efforts should be made to support fulfillment.

Common sense and the common morality in theory and practice.

PubMed

Daly, Patrick

2014-06-01

The unfinished nature of Beauchamp and Childress's account of the common morality after 34 years and seven editions raises questions about what is lacking, specifically in the way they carry out their project, more generally in the presuppositions of the classical liberal tradition on which they rely. Their wide-ranging review of ethical theories has not provided a method by which to move beyond a hypothetical approach to justification or, on a practical level regarding values conflict, beyond a questionable appeal to consensus. My major purpose in this paper is to introduce the thought of Bernard Lonergan as offering a way toward such a methodological breakthrough. In the first section, I consider Beauchamp and Childress's defense of their theory of the common morality. In the second, I relate a persisting vacillation in their argument regarding the relative importance of reason and experience to a similar tension in classical liberal theory. In the third, I consider aspects of Lonergan's generalized empirical method as a way to address problems that surface in the first two sections of the paper: (1) the structural relation of reason and experience in human action; and (2) the importance of theory for practice in terms of what Lonergan calls "common sense" and "general bias."

Healthcare is primary

PubMed Central

Kumar, Raman

2015-01-01

India is undergoing a rapid transformation in terms of governance, administrative reforms, newer policy develoment, and social movements. India is also considered one of the most vibrant economies in the world. The current discourse in public space is dominated by issues such as economic development, security, corruption free governance, gender equity, and women safety. Healthcare though remains a pressing need of population; seems to have taken a backseat. In the era of decreasing subsidies and cautious investment in social sectors, the 2nd National Conference on Family Medicine and Primary Care 2015 (FMPC) brought a focus on “healthcare” in India. The theme of this conference was “Healthcare is Primary.” The conference participants discussed on the theme of why healthcare should be a national priority and why strong primary care should remain at the center of healthcare delivery system. The experts recommended that India needs to strengthen the “general health system” instead of focusing on disease based vertical programs. Public health system should have capacity and skill pool to be able to deliver person centered comprehensive health services to the community. Proactive implementation of policies towards human resource in health is the need of the hour. As the draft National Health Policy 2015 is being debated, “family medicine” (academic primary care), the unfinished agenda of National Health Policy 2002, remains a priority area of implementation. PMID:26985402

Care episode retrieval: distributional semantic models for information retrieval in the clinical domain.

PubMed

Moen, Hans; Ginter, Filip; Marsi, Erwin; Peltonen, Laura-Maria; Salakoski, Tapio; Salanterä, Sanna

2015-01-01

Patients' health related information is stored in electronic health records (EHRs) by health service providers. These records include sequential documentation of care episodes in the form of clinical notes. EHRs are used throughout the health care sector by professionals, administrators and patients, primarily for clinical purposes, but also for secondary purposes such as decision support and research. The vast amounts of information in EHR systems complicate information management and increase the risk of information overload. Therefore, clinicians and researchers need new tools to manage the information stored in the EHRs. A common use case is, given a--possibly unfinished--care episode, to retrieve the most similar care episodes among the records. This paper presents several methods for information retrieval, focusing on care episode retrieval, based on textual similarity, where similarity is measured through domain-specific modelling of the distributional semantics of words. Models include variants of random indexing and the semantic neural network model word2vec. Two novel methods are introduced that utilize the ICD-10 codes attached to care episodes to better induce domain-specificity in the semantic model. We report on experimental evaluation of care episode retrieval that circumvents the lack of human judgements regarding episode relevance. Results suggest that several of the methods proposed outperform a state-of-the art search engine (Lucene) on the retrieval task.

Off the beaten track: Freud, sound and music. Statement of a problem and some historico-critical notes.

PubMed

Baralea, Francesco; Minazzi, Vera

2008-10-01

The authors note that the element of sound and music has no place in the model of mental functioning bequeathed to us by Freud, which is dominated by the visual and the representational. They consider the reasons for this exclusion and its consequences, and ask whether the simple biographical explanation offered by Freud himself is acceptable. This contribution reconstructs the historical and cultural background to that exclusion, cites some relevant emblematic passages, and discusses Freud's position on music and on the aesthetic experience in general. Particular attention is devoted to the relationship between Freud and Lipps, which is important both for the originality of Lipps's thinking in the turn-of-the-century debate and for his ideas on the musical aspects of the foundations of psychic life, at which Freud 'stopped', as he himself wrote. Moreover, the shade of Lipps accompanied Freud throughout his scientific career from 1898 to 1938. Like all foundations, that of psychoanalysis was shaped by a system of inclusions and exclusions. The exclusion of the element of sound and music is understandable in view of the cultural background to the development of the concepts of the representational unconscious and infantile sexuality. While the consequences have been far reaching, the knowledge accumulated since that exclusion enables us to resume, albeit on a different basis, the composition of the 'unfinished symphony' of the relationship between psychoanalysis and music.

Modeling the lag period and exponential growth of Listeria monocytogenes under conditions of fluctuating temperature and water activity values.

PubMed

Muñoz-Cuevas, Marina; Fernández, Pablo S; George, Susan; Pin, Carmen

2010-05-01

The dynamic model for the growth of a bacterial population described by Baranyi and Roberts (J. Baranyi and T. A. Roberts, Int. J. Food Microbiol. 23:277-294, 1994) was applied to model the lag period and exponential growth of Listeria monocytogenes under conditions of fluctuating temperature and water activity (a(w)) values. To model the duration of the lag phase, the dependence of the parameter h(0), which quantifies the amount of work done during the lag period, on the previous and current environmental conditions was determined experimentally. This parameter depended not only on the magnitude of the change between the previous and current environmental conditions but also on the current growth conditions. In an exponentially growing population, any change in the environment requiring a certain amount of work to adapt to the new conditions initiated a lag period that lasted until that work was finished. Observations for several scenarios in which exponential growth was halted by a sudden change in the temperature and/or a(w) were in good agreement with predictions. When a population already in a lag period was subjected to environmental fluctuations, the system was reset with a new lag phase. The work to be done during the new lag phase was estimated to be the workload due to the environmental change plus the unfinished workload from the uncompleted previous lag phase.

Video interaction guidance inviting transcendence of postpartum depressed mothers' self-centered state and holding behavior.

PubMed

Vik, Kari; Braten, Stein

2009-05-01

By sometimes evoking self-absorbed and avoidance behaviors in new mothers, postnatal depression affects the quality of mother-infant interaction, which in turn may invoke distress and avoidance in the infant and cause even more lasting impairment in the child's development. Three depressed mothers, A, B, and C, are reported upon after having been offered counseling in accordance with the Marte Meo approach through jointly watching with the therapist video replays of themselves interacting with their newborns. Clinical vignettes are offered which indicate how empathic and positive support of a sensitive therapist can be helpful in inviting the mother's recognition of her importance to her infant and facilitating mutually gratifying interaction between mother and child. Protocol analyses of select sessions of video-related therapy reveal that two of the mothers sometimes complete the therapist's unfinished statements in an other-centered manner, thereby transcending their initial self-centered state. This is most dramatic in the case of Mother A, who starts out in the first session almost incapable of speech, merely nodding or shaking her head. In addition to other indications of improved mother-infant interaction, comparison of pre- and postguidance windows regarding the three mothers' holding behaviors reveals a shift from an avoidance or anxious stance to closer and more secure holding. Copyright © 2009 Michigan Association for Infant Mental Health.

Quasars and the Caltech-Carnegie Connection

NASA Astrophysics Data System (ADS)

Waluska, Edward R.

2006-12-01

A collaborative relationship existed between the California Institute of Technology(Caltech) and the Carnegie Institution of Washington (Carnegie) beginning in 1946, when a formal agreement was made between the two groups of trustees. This agreement was designed to integrate Mount Wilson Observatory with the new unfinished Palomar Observatory into a single scientific entity. During the period from 1946 to 1979, much astronomical research was done at both institutions as a direct result of this collaboration. Part of this research included the first identification of a radio source with an apparently stellar object by Allan Sandage of Carnegie and Thomas Matthews of Caltech in 1960, and the first identification of the spectral lines from a radio source associated with such an object by Maarten Schmidt of Caltech in 1963. This paper examines how the discovery of these objects, which came to be known as quasars, and the subsequent research on these objects, impacted the relationship between Caltech and Carnegie, such that the relationship was formally dissolved in 1980. In this paper, the controversy surrounding the discovery and the interpretation of quasars is examined to provide further understanding about the working relationship when the two institutions were formally collaborating. Some of the data used in this paper were drawn from interviews of the researchers themselves, and this research forms part of a dissertation for a PhD degree from James Cook University in Townsville, Australia.

Translating weight loss into agency: Men's experiences 5 years after bariatric surgery

PubMed Central

Natvik, Eli; Gjengedal, Eva; Moltu, Christian; Råheim, Målfrid

2015-01-01

Fewer men than women with severe obesity undergo bariatric surgery for weight loss, and knowledge about men's situation after surgery, beyond medical status, is lacking. Our aim was to explore men's experiences with life after bariatric surgery from a long-term perspective. We conducted in-depth interviews with 13 men, aged 28–60 years, between 5 and 7 years after surgery. The analysis was inspired by Giorgi's phenomenological method. We found that agency was pivotal for how the men understood themselves and their lives after surgery. Weight loss meant regaining opportunities for living and acting in unrestricted and independent daily lives, yet surgery remained a radical treatment with complex consequences. Turning to surgery had involved conceptualizing their own body size as illness, which the men had resisted doing for years. After surgery, the rapid and major weight loss and the feelings of being exhausted, weak, and helpless were intertwined. The profound intensity of the weight loss process took the men by surprise. Embodying weight loss and change involved an inevitable renegotiating of experiences connected to the large body. Having bariatric surgery was a long-term process that seemed unfinished 5 years after surgery. Restrictions and insecurity connected to health and illness persist, despite successful weight loss and embodied change. Bariatric surgery initiated a complex and long-lasting life-changing process, involving both increased capacity for agency and illness-like experiences. PMID:26066518

Care episode retrieval: distributional semantic models for information retrieval in the clinical domain

PubMed Central

2015-01-01

Patients' health related information is stored in electronic health records (EHRs) by health service providers. These records include sequential documentation of care episodes in the form of clinical notes. EHRs are used throughout the health care sector by professionals, administrators and patients, primarily for clinical purposes, but also for secondary purposes such as decision support and research. The vast amounts of information in EHR systems complicate information management and increase the risk of information overload. Therefore, clinicians and researchers need new tools to manage the information stored in the EHRs. A common use case is, given a - possibly unfinished - care episode, to retrieve the most similar care episodes among the records. This paper presents several methods for information retrieval, focusing on care episode retrieval, based on textual similarity, where similarity is measured through domain-specific modelling of the distributional semantics of words. Models include variants of random indexing and the semantic neural network model word2vec. Two novel methods are introduced that utilize the ICD-10 codes attached to care episodes to better induce domain-specificity in the semantic model. We report on experimental evaluation of care episode retrieval that circumvents the lack of human judgements regarding episode relevance. Results suggest that several of the methods proposed outperform a state-of-the art search engine (Lucene) on the retrieval task. PMID:26099735

Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging

PubMed Central

Harlow, Siobán D.; Gass, Margery; Hall, Janet E.; Lobo, Roger; Maki, Pauline; Rebar, Robert W.; Sherman, Sherry; Sluss, Patrick M.; de Villiers, Tobie J.

2012-01-01

Objective The aim of this article is to summarize the recommended updates to the 2001 Stages of Reproductive Aging Workshop (STRAW) criteria. The 2011 STRAW + 10 reviewed advances in understanding of the critical changes in hypothalamic-pituitary-ovarian function that occur before and after the final menstrual period. Methods Scientists from five countries and multiple disciplines evaluated data from cohort studies of midlife women and in the context of chronic illness and endocrine disorders on change in menstrual, endocrine, and ovarian markers of reproductive aging including antimüllerian hormone, inhibin-B, follicle-stimulating hormone, and antral follicle count. Modifications were adopted by consensus. Results STRAW + 10 simplified bleeding criteria for the early and late menopausal transition, recommended modifications to criteria for the late reproductive stage (Stage –3) and the early postmenopause stage (Stage +1), provided information on the duration of the late transition (Stage–1) and early postmenopause (Stage +1), and recommended application regardless of women's age, ethnicity, body size, or lifestyle characteristics. Conclusions STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts. Application of the STRAW + 10 staging system should improve comparability of studies of midlife women and facilitate clinical decision making. Nonetheless, important knowledge gaps persist, and seven research priorities are identified. PMID:22343510

Core protein: a pleiotropic keystone in the HBV lifecycle

PubMed Central

Zlotnick, Adam; Venkatakrishnan, Balasubramanian; Tan, Zhenning; Lewellyn, Eric; Turner, William; Francis, Samson

2015-01-01

Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading frames. We argue that the simplicity of the virion correlates with a complexity of functions for viral proteins. We focus on the HBV core protein (Cp), a small (183 residue) protein that self-assembles to form the viral capsid. However, its functions are a little more complicated than that. In an infected cell Cp modulates every step of the viral lifecycle. Cp is bound to nuclear viral DNA and affects its epigenetics. Cp correlates with RNA specificity. Cp assembles specifically on a reverse transcriptase-viral RNA complex or, apparently, nothing at all. Indeed Cp has been one of the model systems for investigation of virus self-assembly. Cp participates in regulation of reverse transcription. Cp signals completion of reverse transcription to support virus secretion. Cp carries both nuclear localization signals and HBV surface antigen (HBsAg) binding sites; both of these functions appear to be regulated by contents of the capsid. Cp can be targeted by antivirals -- while self-assembly is the most accessible of Cp activities, we argue that it makes sense to engage the broader spectrum of Cp function. This article forms part of a symposium in Antiviral Research on “From the discovery of the Australia antigen to the development of new curative therapies for hepatitis B: an unfinished story.” PMID:26129969

Issues in reflection and debriefing: how nurse educators structure experiential activities.

PubMed

Brackenreg, Jenni

2004-12-01

Experiential learning is particularly useful in vocational education programs where theory needs to be linked to practice. Although experiential learning is often advocated in nursing education and the importance of debriefing and reflection is almost always espoused, the focus in the literature has tended to be on detailed descriptions of the action phase with little close analysis of how the reflective phase is facilitated. The Lewinian model described by Kolb [Experiential Learning. Experience as Source of Learning and Development, Prentice-Hall, New Jersey, 1984] and the structuring approach suggested by Thiagarajan [Experiential Learning Packages, Prentice-Hall, Englewood Cliffs, NJ, 1980] have been used as the theoretical context for an exploration of how nurse teachers describe their facilitation of the debriefing and reflective phases of experiential learning activities. Explication of the entire planned experiential learning experience is important for increasing the chances of the student being able to close the experiential learning loop. The more covert reflective phases for facilitating experiential learning are crucial and if neglected, or inexpertly and insensitively handled, may at best lead to poor learning outcomes or at worst lead to emotional damage and ;unfinished business' for the student. Interviews with eight experienced university educators elicited descriptions of how they constructed experiential activities with special reference to their descriptions of how the debriefing or reflective phases were structured.

Chromium released from leather - I: exposure conditions that govern the release of chromium(III) and chromium(VI).

PubMed

Hedberg, Yolanda S; Lidén, Carola; Odnevall Wallinder, Inger

2015-04-01

Approximately 1-3% of the adult population in Europe is allergic to chromium (Cr). A new restriction in REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) based on the ISO 17075 standard has recently been adopted in the EU to limit Cr(VI) in consumer and occupational leather products. The aim of this study was to critically assess key experimental parameters in this standard on the release of Cr(III) and Cr(VI) and their relevance for skin exposure. Four differently tanned, unfinished, leather samples were systematically investigated for their release of Cr(III) and Cr(VI) in relation to surface area, key exposure parameters, temperature, ultraviolet irradiation, and time. Although the total release of Cr was largely unaffected by all investigated parameters, except exposure duration and temperature, the Cr oxidation state was highly dynamic, with reduced amounts of released Cr(VI) with time, owing to the simultaneous release of reducing agents from the leather. Significantly more Cr(III) than Cr(VI) was released from the Cr-tanned leather for all conditions tested, and it continued to be released in artificial sweat up to at least 1 week of exposure. Several parameters were identified that influenced the outcome of the ISO 17075 test. © 2015 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

Chromium(III) and chromium(VI) release from leather during 8 months of simulated use

PubMed Central

Lidén, Carola

2016-01-01

Summary Background Chromium (Cr) release from Cr‐tanned leather articles is a major cause of Cr contact dermatitis. It has been suggested that Cr(VI) release from leather is not necessarily an intrinsic property of the leather, but is strongly dependent on environmental conditions. Objectives To test this hypothesis for long‐term (8 months) simulated use. Materials and methods The release of total Cr and Cr(VI) from Cr‐tanned, unfinished leather was analysed in subsequent phosphate buffer (pH 8.0) immersions for a period of 7.5 months. The effect of combined ultraviolet treatment and alkaline solution (pH 12.1) was tested. Dry storage [20% relative humidity (RH)] was maintained between immersions. Atomic absorption spectroscopy, X‐ray fluorescence and diphenylcarbazide tests were used. Results Cr(VI) release was dependent on previous dry storage or alkaline treatment, but not on duration or number of previous immersions. Cr(III) release decreased with time. Fifty‐two percent of the total Cr released during the last immersion period was Cr(VI). Cr(VI) release exceeded 9 mg/kg in all immersion periods except in the first 10‐day immersion (2.6 mg/kg). Conclusions Cr(VI) release is primarily determined by environmental factors (RH prior to immersion, solution pH, and antioxidant content). The RH should be kept low prior to testing Cr(VI) release from leather. PMID:27144948

Modern cataract surgery: unfinished business and unanswered questions.

PubMed

Apple, David J; Escobar-Gomez, Marcela; Zaugg, Brian; Kleinmann, Guy; Borkenstein, Andreas F

2011-01-01

We summarize information, based on clinicopathologic studies over the past decade, on various cataract intraocular lens (IOL) procedures and modern "specialized" IOLs, that will help surgeons continuously improve long-term results for cataract patients. Although most operations do initially provide excellent refractive correction and visual rehabilitation, late complications occur. These sometimes are missed because they are outside of the routine period of follow-up care. We have tried to determine if the various techniques and IOLs truly deliver the long-term results that we desire. Most safety and efficacy information is derived from the manufacturer and is passed through the U.S. Food and Drug Administration (FDA). This is often based on limited, relatively short-term observations made by the manufacturer. After a lens receives FDA approval, there are few means to assess the outcome of each procedure and lens years later. We rarely hear of a 10- or 20-year follow-up study. We have found that one of the best means to assess long-term results is pathologic analyses. We discuss recently studied aspects of pathologic reactions, such as posterior capsule opacification, intracapsular fibrosis, glistenings, intralenticular opacification, and other issues with the various IOL platforms; we then present a clinicopathological overview of tissues and IOLs from our database. These include hydrophobic and hydrophilic acrylic designs, plate lenses, and a dual optic lens. Copyright © 2011. Published by Elsevier Inc.

Capacity planning in a transitional economy: What issues? Which models?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mubayi, V.; Leigh, R.W.; Bright, R.N.

1996-03-01

This paper is devoted to an exploration of the important issues facing the Russian power generation system and its evolution in the foreseeable future and the kinds of modeling approaches that capture those issues. These issues include, for example, (1) trade-offs between investments in upgrading and refurbishment of existing thermal (fossil-fired) capacity and safety enhancements in existing nuclear capacity versus investment in new capacity, (2) trade-offs between investment in completing unfinished (under construction) projects based on their original design versus investment in new capacity with improved design, (3) incorporation of demand-side management options (investments in enhancing end-use efficiency, for example)more » within the planning framework, (4) consideration of the spatial dimensions of system planning including investments in upgrading electric transmission networks or fuel shipment networks and incorporating hydroelectric generation, (5) incorporation of environmental constraints and (6) assessment of uncertainty and evaluation of downside risk. Models for exploring these issues include low power shutdown (LPS) which are computationally very efficient, though approximate, and can be used to perform extensive sensitivity analyses to more complex models which can provide more detailed answers but are computationally cumbersome and can only deal with limited issues. The paper discusses which models can usefully treat a wide range of issues within the priorities facing decision makers in the Russian power sector and integrate the results with investment decisions in the wider economy.« less

On the self-renewal of teachers.

PubMed

Waters, David J; Waters, Lane S

2011-01-01

In previous issues of the Journal of Veterinary Medical Education, wide-ranging insights on how to achieve excellence in the classroom have been framed by award-winning teachers. These recipes for educational success, however, invariably lack a key ingredient-the teacher's process of self-renewal. What skills and attitudes prime the teacher for continued high performance? To stay out of the ruts of expertise, where does the teacher turn? Teachers and administrators alike recognize its great importance, yet few opportunities for the renewal of teachers are built into the educational system. In this article, we challenge teachers to see their own self-renewal as an underutilized approach to innovate education. We propose a schema for sustained self-renewal: each educator developing her own personalized, hand-picked gallery of intellectual heroes who in turn serve as the educator's life-long teachers. To illustrate the value of this activity, we introduce our own collection of 10 gifted thinkers, providing a brief encounter with each sage as a way of stimulating new thinking on the skills and attitudes that promote personal growth and transformative teaching. We conclude that the veterinary profession should work to create better opportunities for the self-renewal of teachers. By envisioning even our best teachers as unfinished and under construction, we open up a new dialogue situating the self-renewal of teachers at the very core of educational excellence.

Evaluation of the surface roughness of three heat-cured acrylic denture base resins with different conventional lathe polishing techniques: A comparative study.

PubMed

Rao, Duggineni Chalapathi; Kalavathy, N; Mohammad, H S; Hariprasad, A; Kumar, C Ravi

2015-01-01

Surface roughness promotes adhesion and colonization of denture plaque. Therefore, it is important to know the effects of polishing and finishing on the surface roughness of various acrylic resin materials. To evaluate and compare the effects of different conventional lathe polishing techniques on heat cured acrylic resins in producing surface roughness. Three different commercially available heat-cured acrylic resin materials namely DPI, Meliodent and Trevalon Hi were selected. 30 Specimens of each acrylic material (30 x 3 = 90, 10 x 60 x 2mm) were prepared and divided into 5 groups, each group consisted of 6 Nos. of specimens per material(6x3=18) and were grouped as Group A(unfinished), Group B (finished), Group C (Polishing Paste), Group D (Polishing Cake) and Group E (Pumice and Gold rouge). The resulted surface roughness (μm) was measured using Perthometer and observed under Scanning Electron Microscope. The values obtained were subjected statistical analyses. Among the materials tested, better results were obtained with Trevalon Hi followed by Meliodent and DPI. Among the polishing methods used, superior results were obtained with universal polishing paste followed by polishing cake; Pumice and Gold rouge. Although Pumice and Gold rouge values produced greater roughness value, they were well within the threshold value of 0.2 mm.

Alcohol-impaired driving and its consequences in the United States: the past 25 years.

PubMed

Williams, Allan F

2006-01-01

Progress in dealing with the alcohol-impaired driving problem in the United States during the past 25 years is addressed. Trends in various measures of the problem were tracked and a thorough review of the relevant literature conducted. In the 1980s and continuing into the early 1990s, major decreases occurred in alcohol-impaired driving and its consequences. The contribution of alcohol to fatal crashes dropped by 35-40% during this period. Two primary reasons for the decline appear to be the emergence of citizen activist groups that mobilized public support and attention to the problem, and the proliferation of effective laws. Since about 1995 the alcohol-impaired driving problem has stabilized at a reduced but still quite high level. Highway safety organizations and citizen activist groups have continued to highlight the problem, but its status as a social issue has diminished. We basically know what the primary target groups are, and we know measures that would work to reduce the problem if implemented more fully. We know that political leadership, state task forces, and media advocacy are important ingredients in addressing the problem. It is likely that a resurgence in citizen activism will be necessary to foster these elements and refocus the nation on the unfinished battle against alcohol-impaired driving. Alcohol-impaired driving is still a major problem that needs continuing attention.

The Double Burden of Malnutrition in Countries Passing through the Economic Transition.

PubMed

Prentice, Andrew M

2018-01-01

Undernutrition in both its acute and chronic forms (wasting and stunting) is strongly inversely correlated with the wealth of nations. Consequently, as many low- and middle-income countries (LMICs) achieve economic advancement and pass through the so-called "nutrition transition," their rates of undernutrition decline. Many countries successfully achieved the Millennium Development Goal of halving undernutrition and whole continents have been transformed in recent decades. The exception is Africa where the slower rates of decline in the prevalence of undernutrition has been overtaken by population growth so that the absolute number of stunted children is rising. In many regions, economic transition is causing a rapid increase in the number of overweight and obese people. The rapidity of this rise is such that many nations bear the simultaneous burdens of under- and overnutrition; termed the "double burden" of malnutrition. This double burden, accompanied as it is by the unfinished agenda of high levels of infectious diseases, is crippling the health systems of many LMICs and thus requires urgent attention. Although the prognosis looks threatening for many poor countries, they have the advantage of being able to learn from the mistakes made by other nations that have passed through the transition before them. Concerted action across many arms of government would achieve huge future dividends in health and wealth for any nations that can grasp the challenge. © 2018 S. Karger AG, Basel.

Does increased gender equality lead to a convergence of health outcomes for men and women? A study of Swedish municipalities.

PubMed

Backhans, Mona C; Lundberg, Michael; Månsdotter, Anna

2007-05-01

This study examines associations between indicators of gender equality and public health. We compare Swedish municipalities on nine indicators in both the private and public sphere, and an additive index, and study the correlations with indicators of morbidity and mortality. The hypothesis that a higher level of gender equality is associated with a convergence of health outcomes (life expectancy, sickness absence) between men and women was supported for equality of part-time employment, managerial positions and economic resources for morbidity, and for temporary parental leave for mortality. Our main finding is that gender equality was generally correlated with poorer health for both men and women. Our conclusions are tentative due to the methodological uncertainties. However, the results suggest an unfortunate trade-off between gender equality as we know it and public health. Sweden may have reached a critical point where further one-sided expansion by women into traditionally male roles, spheres and activities will not lead to positive health effects unless men also significantly alter their behaviour. Negative effects of this unfinished equality might be found both for women, who have become more burdened, and men, who as a group have lost many of their old privileges. We propose that this contention be confronted and discussed by policymakers, researchers and others. Further studies are also needed to corroborate or dispute these findings.

Merging Infrasound and Electromagnetic Signals as a Means for Nuclear Explosion Detection

NASA Astrophysics Data System (ADS)

Ashkenazy, Joseph; Lipshtat, Azi; Kesar, Amit S.; Pistinner, Shlomo; Ben Horin, Yochai

2016-04-01

The infrasound monitoring network of the CTBT consists of 60 stations. These stations are capable of detecting atmospheric events, and may provide approximate location within time scale of a few hours. However, the nature of these events cannot be deduced from the infrasound signal. More than two decades ago it was proposed to use the electromagnetic pulse (EMP) as a means of discriminating nuclear explosion from other atmospheric events. An EMP is a unique signature of nuclear explosion and is not detected from chemical ones. Nevertheless, it was decided to exclude the EMP technology from the official CTBT verification regime, mainly because of the risk of high false alarm rate, due to lightning electromagnetic pulses [1]. Here we present a method of integrating the information retrieved from the infrasound system with the EMP signal which enables us to discriminate between lightning discharges and nuclear explosions. Furthermore, we show how spectral and other characteristics of the electromagnetic signal emitted from a nuclear explosion are distinguished from those of lightning discharge. We estimate the false alarm probability of detecting a lightning discharge from a given area of the infrasound event, and identifying it as a signature of a nuclear explosion. We show that this probability is very low and conclude that the combination of infrasound monitoring and EMP spectral analysis may produce a reliable method for identifying nuclear explosions. [1] R. Johnson, Unfinished Business: The Negotiation of the CTBT and the End of Nuclear Testing, United Nations Institute for Disarmament Research, 2009.

Meaning-centered dream work with hospice patients: A pilot study.

PubMed

Wright, Scott T; Grant, Pei C; Depner, Rachel M; Donnelly, James P; Kerr, Christopher W

2015-10-01

Hospice patients often struggle with loss of meaning, while many experience meaningful dreams. The purpose of this study was to conduct a preliminary exploration into the process and therapeutic outcomes of meaning-centered dream work with hospice patients. A meaning-centered variation of the cognitive-experiential model of dream work (Hill, 1996; 2004) was tested with participants. This variation was influenced by the tenets of meaning-centered psychotherapy (Breitbart et al., 2012). A total of 12 dream-work sessions were conducted with 7 hospice patients (5 women), and session transcripts were analyzed using the consensual qualitative research (CQR) method (Hill, 2012). Participants also completed measures of gains from dream interpretation in terms of existential well-being and quality of life. Participants' dreams generally featured familiar settings and living family and friends. Reported images from dreams were usually connected to feelings, relationships, and the concerns of waking life. Participants typically interpreted their dreams as meaning that they needed to change their way of thinking, address legacy concerns, or complete unfinished business. Generally, participants developed and implemented action plans based on these interpretations, despite their physical limitations. Participants described dream-work sessions as meaningful, comforting, and helpful. High scores on a measure of gains from dream interpretation were reported, consistent with qualitative findings. No adverse effects were reported or indicated by assessments. Our results provided initial support for the feasibility and helpfulness of dream work in this population. Implications for counseling with the dying and directions for future research were also explored.

Finishing bacterial genome assemblies with Mix.

PubMed

Soueidan, Hayssam; Maurier, Florence; Groppi, Alexis; Sirand-Pugnet, Pascal; Tardy, Florence; Citti, Christine; Dupuy, Virginie; Nikolski, Macha

2013-01-01

Among challenges that hamper reaping the benefits of genome assembly are both unfinished assemblies and the ensuing experimental costs. First, numerous software solutions for genome de novo assembly are available, each having its advantages and drawbacks, without clear guidelines as to how to choose among them. Second, these solutions produce draft assemblies that often require a resource intensive finishing phase. In this paper we address these two aspects by developing Mix , a tool that mixes two or more draft assemblies, without relying on a reference genome and having the goal to reduce contig fragmentation and thus speed-up genome finishing. The proposed algorithm builds an extension graph where vertices represent extremities of contigs and edges represent existing alignments between these extremities. These alignment edges are used for contig extension. The resulting output assembly corresponds to a set of paths in the extension graph that maximizes the cumulative contig length. We evaluate the performance of Mix on bacterial NGS data from the GAGE-B study and apply it to newly sequenced Mycoplasma genomes. Resulting final assemblies demonstrate a significant improvement in the overall assembly quality. In particular, Mix is consistent by providing better overall quality results even when the choice is guided solely by standard assembly statistics, as is the case for de novo projects. Mix is implemented in Python and is available at https://github.com/cbib/MIX, novel data for our Mycoplasma study is available at http://services.cbib.u-bordeaux2.fr/mix/.

Quasars and the Caltech-Carnegie Connection

NASA Astrophysics Data System (ADS)

Waluska, Edward R.

2007-07-01

A collaborative relationship existed between the California Institute of Technology (Caltech) and the Carnegie Institution of Washington (Carnegie) beginning in 1946, when a formal agreement was signed between the two groups of trustees. This agreement was designed to integrate Mount Wilson Observatory and the new unfinished Palomar Observatory into a single scientific entity. During the period from 1946 to 1979, much astronomical research was done at both institutions as a direct result of this collaboration. Part of this research included the first identification of a radio source with an apparently stellar object by Allan Sandage of Carnegie and Thomas Matthews of Caltech in 1960, and the first identification of spectral lines at large redshift from a radio source associated with such an object by Maarten Schmidt of Caltech in 1963. This paper examines how the discovery of these objects - which came to be known as quasars - and subsequent research an them, indirectly had an impact an the relationship between Caltech and Carnegie by leading to an environment of increased competitiveness that eventually resulted in the formal dissolution of the relationship in 1980. In this paper, the controversy surrounding the discovery and the interpretation of quasars is examined to provide further understanding about the working relationship when the two institutions were formally collaborating. Some of the data used in this paper were drawn from personal correspondence and interviews with the researchers themselves, and this research forms part of a dissertation for a Ph.D. degree in the Centre for Astronomy at James Cook University, Townsville, Australia.

Earth Observation

NASA Image and Video Library

2012-07-25

ISS032-E-009123 (26 July 2012) --- Pyramids at Giza, Egypt are featured in this image photographed by an Expedition 32 crew member on the International Space Station. The Great Pyramids at Giza (center) are the last of the Seven Wonders of the Ancient World, and are perhaps the most famous of the ancient monuments in the Nile River Delta region of Egypt. They are also a favorite subject of photography from orbit ? particularly when high resolution imagery can be obtained. The southeast-facing sides of the pyramids of the pharaohs Khufu, Khafre, and Menkaure are all brightly illuminated by the sun, while the northwest facing sides are in shadow. This shadowing also highlights smaller unfinished pyramids to the south of Menkaure?s pyramid, as well as fields of rectangular flat roofed mastabas (tombs) to the east and west of Khufu?s pyramid. While not as grand as the pyramids, mastabas were the burial places of prominent persons during the periods of the ancient pharaohs. To the southeast of Khufu?s pyramid, the head and rear haunches of the Sphinx are also visible (albeit not clearly). It is a short distance between the glories of ancient Egypt and the modern Cairo metropolitan area to the north and east. The green vegetation of a hotel golf course (center left), and the numerous building and streets of El Giza, provide stark contrast to the bare rock and soil of the adjacent desert. Roadways visible in the desert (right) connect the urban regions to the east with further development to the north.

Harry Stack Sullivan Colloquium: George Herbert Mead and Harry Stack Sullivan: an unfinished synthesis.

PubMed

Cottrell, L S

1978-05-01

HOW DO YOU create a new self? However he may phrase this question, it is a central theoretical and practical concern of the therapist every time he confronts a client who comes to him for help. What are the processes out of which the human self emerges? However he may phrase the question, it is a central concern of the social psychologist. The obvious convergence of interests indicated by these two questions should occasion no surprise among students of Sullivan and Mead. What perhaps should be surprising is that an effective synthesis of their theories has progressed no further than it has to date. My remarks today are based on the conviction that a more adequate psychiatric theory and practice and a more complete social psychological theory and research program depend on such a synthesis. Behavioral scientists concerned with the development of a truly interactionist social psychology are, I believe, generally agreed that George Herbert Mead (1863-1931), philosopher and social psychologist, and Harry Stack Sullivan (1892-1949), psychiatrist and social psychologist, have laid conceptual foundations upon which such a discipline can be erected. Now a vast assortment of activities is tagged as social psychology and its boundaries are, indeed, difficult to draw. However, for our present purposes we can define its focus as the study of the processes and products of inter- and intrapersonal and inter- and intragoup interaction, let the boundaries fall where they will.

Integrated G and C Implementation within IDOS: A Simulink Based Reusable Launch Vehicle Simulation

NASA Technical Reports Server (NTRS)

Fisher, Joseph E.; Bevacqua, Tim; Lawrence, Douglas A.; Zhu, J. Jim; Mahoney, Michael

2003-01-01

The implementation of multiple Integrated Guidance and Control (IG&C) algorithms per flight phase within a vehicle simulation poses a daunting task to coordinate algorithm interactions with the other G&C components and with vehicle subsystems. Currently being developed by Universal Space Lines LLC (USL) under contract from NASA, the Integrated Development and Operations System (IDOS) contains a high fidelity Simulink vehicle simulation, which provides a means to test cutting edge G&C technologies. Combining the modularity of this vehicle simulation and Simulink s built-in primitive blocks provide a quick way to implement algorithms. To add discrete-event functionality to the unfinished IDOS simulation, Vehicle Event Manager (VEM) and Integrated Vehicle Health Monitoring (IVHM) subsystems were created to provide discrete-event and pseudo-health monitoring processing capabilities. Matlab's Stateflow is used to create the IVHM and Event Manager subsystems and to implement a supervisory logic controller referred to as the Auto-commander as part of the IG&C to coordinate the control system adaptation and reconfiguration and to select the control and guidance algorithms for a given flight phase. Manual creation of the Stateflow charts for all of these subsystems is a tedious and time-consuming process. The Stateflow Auto-builder was developed as a Matlab based software tool for the automatic generation of a Stateflow chart from information contained in a database. This paper describes the IG&C, VEM and IVHM implementations in IDOS. In addition, this paper describes the Stateflow Auto-builder.

Use of Graph Database for the Integration of Heterogeneous Biological Data.

PubMed

Yoon, Byoung-Ha; Kim, Seon-Kyu; Kim, Seon-Young

2017-03-01

Understanding complex relationships among heterogeneous biological data is one of the fundamental goals in biology. In most cases, diverse biological data are stored in relational databases, such as MySQL and Oracle, which store data in multiple tables and then infer relationships by multiple-join statements. Recently, a new type of database, called the graph-based database, was developed to natively represent various kinds of complex relationships, and it is widely used among computer science communities and IT industries. Here, we demonstrate the feasibility of using a graph-based database for complex biological relationships by comparing the performance between MySQL and Neo4j, one of the most widely used graph databases. We collected various biological data (protein-protein interaction, drug-target, gene-disease, etc.) from several existing sources, removed duplicate and redundant data, and finally constructed a graph database containing 114,550 nodes and 82,674,321 relationships. When we tested the query execution performance of MySQL versus Neo4j, we found that Neo4j outperformed MySQL in all cases. While Neo4j exhibited a very fast response for various queries, MySQL exhibited latent or unfinished responses for complex queries with multiple-join statements. These results show that using graph-based databases, such as Neo4j, is an efficient way to store complex biological relationships. Moreover, querying a graph database in diverse ways has the potential to reveal novel relationships among heterogeneous biological data.

Experience from a multi-country initiative to improve the monitoring of selected reproductive health indicators in Africa.

PubMed

Barreix, Maria; Tunçalp, Özge; Mutombo, Namuunda; Adegboyega, Ayotunde A; Say, Lale

2017-05-01

Universal access to sexual and reproductive health remains part of the unfinished business of global development in Africa. To achieve it, health interventions should be monitored using programmatic indicators. WHO's Strengthening Measurement of Reproductive Health Indicators in Africa initiative, implemented in Ghana, Nigeria, Kenya, Uganda, and Zimbabwe, aimed to improve national information systems for routine monitoring of reproductive health indicators. Participating countries developed action plans employing a two-pronged strategy: (1) revising, standardizing, and harmonizing existing reproductive health indicators captured through routine information-systems; and (2) building data-collection capacity through training and supervision at select pilot sites. Country teams evaluated existing and new indicators, and outlined barriers to strengthening routine measurement. Activities included updating abortion-care guidelines (spontaneous and induced abortions), providing training on laws surrounding induced abortions, and improving feedback mechanisms. The country teams updated monitoring and evaluation frameworks, and attempted to build recording/reporting capacity in selected pilot areas. Barriers to implementing the initiative that were encountered included restrictive induced-abortion laws, staff turn-over, and administrative delays, including low capacity among healthcare staff and competing priorities for staff time. The areas identified for further improvement were up-scaling programs to a national level, creating scorecards to record data, increasing collaborations with the private sector, conducting related costing exercises, and performing ex-post evaluations. © 2017 World Health Organization; licensed by Wiley on behalf of International Federation of Gynecology and Obstetrics.

Population genetic implications from sequence variation in four Y chromosome genes.

PubMed

Shen, P; Wang, F; Underhill, P A; Franco, C; Yang, W H; Roxas, A; Sung, R; Lin, A A; Hyman, R W; Vollrath, D; Davis, R W; Cavalli-Sforza, L L; Oefner, P J

2000-06-20

Some insight into human evolution has been gained from the sequencing of four Y chromosome genes. Primary genomic sequencing determined gene SMCY to be composed of 27 exons that comprise 4,620 bp of coding sequence. The unfinished sequencing of the 5' portion of gene UTY1 was completed by primer walking, and a total of 20 exons were found. By using denaturing HPLC, these two genes, as well as DBY and DFFRY, were screened for polymorphic sites in 53-72 representatives of the five continents. A total of 98 variants were found, yielding nucleotide diversity estimates of 2.45 x 10(-5), 5. 07 x 10(-5), and 8.54 x 10(-5) for the coding regions of SMCY, DFFRY, and UTY1, respectively, with no variant having been observed in DBY. In agreement with most autosomal genes, diversity estimates for the noncoding regions were about 2- to 3-fold higher and ranged from 9. 16 x 10(-5) to 14.2 x 10(-5) for the four genes. Analysis of the frequencies of derived alleles for all four genes showed that they more closely fit the expectation of a Luria-Delbrück distribution than a distribution expected under a constant population size model, providing evidence for exponential population growth. Pairwise nucleotide mismatch distributions date the occurrence of population expansion to approximately 28,000 years ago. This estimate is in accord with the spread of Aurignacian technology and the disappearance of the Neanderthals.

A comparative evaluation of genome assembly reconciliation tools.

PubMed

Alhakami, Hind; Mirebrahim, Hamid; Lonardi, Stefano

2017-05-18

The majority of eukaryotic genomes are unfinished due to the algorithmic challenges of assembling them. A variety of assembly and scaffolding tools are available, but it is not always obvious which tool or parameters to use for a specific genome size and complexity. It is, therefore, common practice to produce multiple assemblies using different assemblers and parameters, then select the best one for public release. A more compelling approach would allow one to merge multiple assemblies with the intent of producing a higher quality consensus assembly, which is the objective of assembly reconciliation. Several assembly reconciliation tools have been proposed in the literature, but their strengths and weaknesses have never been compared on a common dataset. We fill this need with this work, in which we report on an extensive comparative evaluation of several tools. Specifically, we evaluate contiguity, correctness, coverage, and the duplication ratio of the merged assembly compared to the individual assemblies provided as input. None of the tools we tested consistently improved the quality of the input GAGE and synthetic assemblies. Our experiments show an increase in contiguity in the consensus assembly when the original assemblies already have high quality. In terms of correctness, the quality of the results depends on the specific tool, as well as on the quality and the ranking of the input assemblies. In general, the number of misassemblies ranges from being comparable to the best of the input assembly to being comparable to the worst of the input assembly.

Use of Graph Database for the Integration of Heterogeneous Biological Data

PubMed Central

Yoon, Byoung-Ha; Kim, Seon-Kyu

2017-01-01

Understanding complex relationships among heterogeneous biological data is one of the fundamental goals in biology. In most cases, diverse biological data are stored in relational databases, such as MySQL and Oracle, which store data in multiple tables and then infer relationships by multiple-join statements. Recently, a new type of database, called the graph-based database, was developed to natively represent various kinds of complex relationships, and it is widely used among computer science communities and IT industries. Here, we demonstrate the feasibility of using a graph-based database for complex biological relationships by comparing the performance between MySQL and Neo4j, one of the most widely used graph databases. We collected various biological data (protein-protein interaction, drug-target, gene-disease, etc.) from several existing sources, removed duplicate and redundant data, and finally constructed a graph database containing 114,550 nodes and 82,674,321 relationships. When we tested the query execution performance of MySQL versus Neo4j, we found that Neo4j outperformed MySQL in all cases. While Neo4j exhibited a very fast response for various queries, MySQL exhibited latent or unfinished responses for complex queries with multiple-join statements. These results show that using graph-based databases, such as Neo4j, is an efficient way to store complex biological relationships. Moreover, querying a graph database in diverse ways has the potential to reveal novel relationships among heterogeneous biological data. PMID:28416946

The weight of unfinished plate: A survey based characterization of restaurant food waste in Chinese cities.

PubMed

Wang, Ling-En; Liu, Gang; Liu, Xiaojie; Liu, Yao; Gao, Jun; Zhou, Bin; Gao, Si; Cheng, Shengkui

2017-08-01

Consumer food waste has attracted increasing public, academic, and political attention in recent years, due to its adverse resource, environmental, and socioeconomic impacts. The scales and patterns of consumer food waste, especially in developing countries, however, remain poorly understood, which may hinder the global effort of reducing food waste. In this study, based on a direct weighing method and a survey of 3557 tables in 195 restaurants in four case cities, we investigated the amount and patterns of restaurant food waste in China in 2015. Food waste per capita per meal in the four cities was 93g, consisting mainly of vegetables (29%), rice (14%), aquatic products (11%), wheat (10%), and pork (8%). This equals to approximately 11kg/cap/year and is not far from that of western countries, although per capita GDP of China is still much lower. We found also that food waste per capita per meal varies considerably by cities (Chengdu and Lhasa higher than Shanghai and Beijing), consumer groups (tourists higher than local residents), restaurant categories (more waste in larger restaurants), and purposes of meals (friends gathering and business banquet higher than working meal and private dining). Our pilot study provides a first, to our best knowledge, empirically determined scales and patterns of restaurant food waste in Chinese cities, and could help set targeted interventions and benchmark national food waste reduction targets. Copyright © 2017 Elsevier Ltd. All rights reserved.

Factors Associated with Anxiety About Colonoscopy: The Preparation, the Procedure, and the Anticipated Findings.

PubMed

Shafer, L A; Walker, J R; Waldman, C; Yang, C; Michaud, V; Bernstein, C N; Hathout, L; Park, J; Sisler, J; Restall, G; Wittmeier, K; Singh, H

2018-03-01

Previous research has assessed anxiety around colonoscopy procedures, but has not considered anxiety related to different aspects related to the colonoscopy process. Before colonoscopy, we assessed anxiety about: bowel preparation, the procedure, and the anticipated results. We evaluated associations between patient characteristics and anxiety in each area. An anonymous survey was distributed to patients immediately prior to their outpatient colonoscopy in six hospitals and two ambulatory care centers in Winnipeg, Canada. Anxiety was assessed using a visual analog scale. For each aspect, logistic regression models were used to explore associations between patient characteristics and high anxiety. A total of 1316 respondents completed the questions about anxiety (52% female, median age 56 years). Anxiety scores > 70 (high anxiety) were reported by 18% about bowel preparation, 29% about the procedure, and 28% about the procedure results. High anxiety about bowel preparation was associated with female sex, perceived unclear instructions, unfinished laxative, and no previous colonoscopies. High anxiety about the procedure was associated with female sex, no previous colonoscopies, and confusing instructions. High anxiety about the results was associated with symptoms as an indication for colonoscopy and instructions perceived as confusing. Fewer people had high anxiety about preparation than about the procedure and findings of the procedure. There are unique predictors of anxiety about each colonoscopy aspect. Understanding the nuanced differences in aspects of anxiety may help to design strategies to reduce anxiety, leading to improved acceptance of the procedure, compliance with preparation instructions, and less discomfort with the procedure.

Chromium(III) and chromium(VI) release from leather during 8 months of simulated use.

PubMed

Hedberg, Yolanda S; Lidén, Carola

2016-08-01

Chromium (Cr) release from Cr-tanned leather articles is a major cause of Cr contact dermatitis. It has been suggested that Cr(VI) release from leather is not necessarily an intrinsic property of the leather, but is strongly dependent on environmental conditions. To test this hypothesis for long-term (8 months) simulated use. The release of total Cr and Cr(VI) from Cr-tanned, unfinished leather was analysed in subsequent phosphate buffer (pH 8.0) immersions for a period of 7.5 months. The effect of combined ultraviolet treatment and alkaline solution (pH 12.1) was tested. Dry storage [20% relative humidity (RH)] was maintained between immersions. Atomic absorption spectroscopy, X-ray fluorescence and diphenylcarbazide tests were used. Cr(VI) release was dependent on previous dry storage or alkaline treatment, but not on duration or number of previous immersions. Cr(III) release decreased with time. Fifty-two percent of the total Cr released during the last immersion period was Cr(VI). Cr(VI) release exceeded 9 mg/kg in all immersion periods except in the first 10-day immersion (2.6 mg/kg). Cr(VI) release is primarily determined by environmental factors (RH prior to immersion, solution pH, and antioxidant content). The RH should be kept low prior to testing Cr(VI) release from leather. © 2016 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

Coordination of palliative cancer care in the community: "unfinished business".

PubMed

Brazil, Kevin; Bainbridge, Daryl; Sussman, Jonathan; Whelan, Tim; O'Brien, Mary Ann; Pyette, Nancy

2009-07-01

This study assessed the degree to which services in south-central Ontario, Canada, were coordinated to meet the supportive care needs of palliative cancer patients and their families. Programs within the region that were identified as providing supportive care to palliative cancer patients and their families were eligible to participate in the study. Program administrators participated in a semi-structured interview and direct-care providers completed a survey instrument. Administrators from 37 (97%) of 38 eligible programs and 109 direct-care providers representing 26 (70%) programs participated in the study. Most administrator and direct-care respondents felt that existing services in the community were responsive to palliative care patients' individual needs. However, at a system level, most respondents in both groups felt that required services were not available and that resources were inadequate. The most frequently reported unmet supportive care need identified by both respondent groups was psychological/social support. Most administrator (69%) and direct-care (64%) respondents felt that palliative care services were not available when needed. The majority of administrator and direct-care respondents were satisfied with the exchange of patient information within and between programs, although direct-care staff identified a deficit in information transferred on palliative care patients' social/psychological status. The study demonstrated the value of a theory-based approach to evaluate the coordination of palliative cancer care services. The findings revealed that service programs faced significant challenges in their efforts to provide coordinated care.

Abortion: Still Unfinished Agenda in Nepal.

PubMed

Shrestha, Dirgha Raj; Regmi, Shibesh Chandra; Dangal, Ganesh

2018-03-13

Unsafe abortion is affecting a lot, in health, socio-economic and health care cost of many countries. Despite invention of simple technology and scientifically approved safe abortion methods, women and girls are still using unsafe abortion practices. Since 2002, Nepal has achieved remarkable progress in developing policies, guidelines, task shifting, training human resources and increasing access to services. However, more than half of abortion in Nepal are performed clandestinely by untrained or unapproved providers or induced by pregnant woman herself. Knowledge on legalization and availability of safe abortion service among women is still very poor. Stigma on abortion still persists among community people, service providers, managers, and policy makers. Access to safe abortion, especially in remote and rural areas, is still far behind as compared to their peers from urban areas. The existing law is not revised in the spirit of current Constitution of Nepal and rights-based approach. The existence of abortion stigma and the shifting of the government structure from unitary system to federalism in absence of a complete clarity on how the safe abortion service gets integrated into the local government structure might create challenge to sustain existing developments. There is, therefore, a need for all stakeholders to make a lot of efforts and allocate adequate resources to sustain current achievements and ensure improvements in creating a supportive social environment for women and girls so that they will be able to make informed decisions and access to safe abortion service in any circumstances.

The forgotten majority: unfinished business in cardiovascular risk reduction.

PubMed

Libby, Peter

2005-10-04

Despite meaningful progress in the identification of risk factors and the development of highly effective clinical tools, deaths from cardiovascular disease continue to increase worldwide. Sparked by an obesity epidemic, the metabolic syndrome and the rising incidence of type 2 diabetes have led to an upsurge of cardiovascular risk. Although pharmacologic treatments with the statin class of drugs have reduced cholesterol levels and lowered mortality rates, several large controlled clinical trials, including the Scandinavian Simvastatin Survival Study, the Cholesterol and Recurrent Events trial, the Air Force/Texas Coronary Atherosclerosis Prevention studies, and Long-term Intervention with Pravastatin in Ischemic Disease study, have indicated that cardiovascular events continue to occur in two thirds of all patients. Follow-up studies, such as the Heart Protection Study and the Pravastatin or Atorvastatin Evaluation and Infection Therapy/Thrombolysis In Myocardial Infarction-22 trials, reinforced these earlier results. Although therapy with gemfibrozil, a fibric acid derivative, showed reduced occurrence of cardiovascular events in the Helsinki Heart Study and the Veterans Affairs HDL Intervention Trial, results of other studies, e.g., the Bezafibrate Intervention Program and the Diabetes Atherosclerosis Intervention study, showed less encouraging results. Although lifestyle modifications, such as improved diet and increased exercise levels, benefit general health and the metabolic syndrome and insulin resistance in particular, most people continue to resist changes in their daily routines. Thus, physicians must continue to educate their patients regarding an optimal balance of drug therapy and personal behavior.

An interactive local flattening operator to support digital investigations on artwork surfaces.

PubMed

Pietroni, Nico; Massimiliano, Corsini; Cignoni, Paolo; Scopigno, Roberto

2011-12-01

Analyzing either high-frequency shape detail or any other 2D fields (scalar or vector) embedded over a 3D geometry is a complex task, since detaching the detail from the overall shape can be tricky. An alternative approach is to move to the 2D space, resolving shape reasoning to easier image processing techniques. In this paper we propose a novel framework for the analysis of 2D information distributed over 3D geometry, based on a locally smooth parametrization technique that allows us to treat local 3D data in terms of image content. The proposed approach has been implemented as a sketch-based system that allows to design with a few gestures a set of (possibly overlapping) parameterizations of rectangular portions of the surface. We demonstrate that, due to the locality of the parametrization, the distortion is under an acceptable threshold, while discontinuities can be avoided since the parametrized geometry is always homeomorphic to a disk. We show the effectiveness of the proposed technique to solve specific Cultural Heritage (CH) tasks: the analysis of chisel marks over the surface of a unfinished sculpture and the local comparison of multiple photographs mapped over the surface of an artwork. For this very difficult task, we believe that our framework and the corresponding tool are the first steps toward a computer-based shape reasoning system, able to support CH scholars with a medium they are more used to. © 2011 IEEE

ISEA2007 panel: Integration of better exposure characterizations into disaster preparedness for responders and the public

PubMed Central

Rodes, Charles E.; Pellizzari, Edo D.; Dellarco, Michael J.; Erickson, Mitchell D.; Vallero, Daniel A.; Reissman, Dori B.; Lioy, Paul J.; Lippmann, Morton; Burke, Thomas A.; Goldstein, Bernard D.

2014-01-01

An expert panel was convened in October 2007 at the International Society for Exposure Analysis Annual Meeting in Durham, NC, entitled “The Path Forward in Disaster Preparedness Since WTC—Exposure Characterization and Mitigation: Substantial Unfinished Business!” The panel prospectively discussed the critical exposure issues being overlooked during disaster responses and highlighted the needs for an optimal blending of exposure characterizations and hazard controls within disaster settings. The cases were made that effective and timely exposure characterizations must be applied during responses to any disaster, whether terrorist, manmade, or natural in origin. The consistent application of exposure sciences across acute and chronic disaster timelines will assure that the most effective strategies are applied to collect the needed information to guide risk characterization and management approaches. Exposure sciences must be effectively applied across all phases of a disaster (defined as rescue, reentry, recovery, and rehabitation—the four Rs) to appropriately characterize risks and guide risk-mitigation approaches. Failure to adequately characterize and control hazardous exposures increases the likelihood of excess morbidity and mortality. Advancing the infrastructure and the technologies to collect the right exposure information before, during, and immediately after disasters would advance our ability to define risks and protect responders and the public better. The panel provided conclusions, recommendations, and next steps toward effective and timely integration of better exposure science into disaster preparedness, including the need for a subsequent workshop to facilitate this integration. All panel presentations and a summary were uploaded to the ISES1 website (http://www.iseaweb.org/Disaster_Preparedness/index.php). PMID:18685563

Dynamic growth of slip surfaces in catastrophic landslides.

PubMed

Germanovich, Leonid N; Kim, Sihyun; Puzrin, Alexander M

2016-01-01

This work considers a landslide caused by the shear band that emerges along the potential slip (rupture) surface. The material above the band slides downwards, causing the band to grow along the slope. This growth may first be stable (progressive), but eventually becomes dynamic (catastrophic). The landslide body acquires a finite velocity before it separates from the substrata. The corresponding initial-boundary value problem for a dynamic shear band is formulated within the framework of Palmer & Rice's ( Proc. R. Soc. Lond. A 332 , 527-548. (doi:10.1098/rspa.1973.0040)) approach, which is generalized to the dynamic case. We obtain the exact, closed-form solution for the band velocity and slip rate. This solution assesses when the slope fails owing to a limiting condition near the propagating tip of the shear band. Our results are applicable to both submarine and subaerial landslides of this type. It appears that neglecting dynamic (inertia) effects can lead to a significant underestimation of the slide size, and that the volumes of catastrophic slides can exceed the volumes of progressive slides by nearly a factor of 2. As examples, we consider the Gaviota and Humboldt slides offshore of California, and discuss landslides in normally consolidated sediments and sensitive clays. In particular, it is conceivable that Humboldt slide is unfinished and may still displace a large volume of sediments, which could generate a considerable tsunami. We show that in the case of submarine slides, the effect of water resistance on the shear band dynamics may frequently be limited during the slope failure stage. For a varying slope angle, we formulate a condition of slide cessation.

Development and evaluation of the Dignity Talk question framework for palliative patients and their families: A mixed-methods study.

PubMed

Guo, Qiaohong; Chochinov, Harvey Max; McClement, Susan; Thompson, Genevieve; Hack, Tom

2018-01-01

Effective patient-family communication can reduce patients' psychosocial distress and relieve family members' current suffering and their subsequent grief. However, terminally ill patients and their family members often experience great difficulty in communicating their true feelings, concerns, and needs to each other. To develop a novel means of facilitating meaningful conversations for palliative patients and family members, coined Dignity Talk, explore anticipated benefits and challenges of using Dignity Talk, and solicit suggestions for protocol improvement. A convergent parallel mixed-methods design. Dignity Talk, a self-administered question list, was designed to prompt end-of-life conversations, adapted from the Dignity Therapy question framework. Participants were surveyed to evaluate the Dignity Talk question framework. Data were analyzed using qualitative and quantitative methods. A total of 20 palliative patients, 20 family members, and 34 healthcare providers were recruited from two inpatient palliative care units in Winnipeg, Canada. Most Dignity Talk questions were endorsed by the majority of patients and families (>70%). Dignity Talk was revised to be convenient and flexible to use, broadly accessible, clearly stated, and sensitively worded. Participants felt Dignity Talk would be valuable in promoting conversations, enhancing family connections and relationships, enhancing patient sense of value and dignity, promoting effective interaction, and attending to unfinished business. Participants suggested that patients and family members be given latitude to respond only to questions that are meaningful to them and within their emotional capacity to broach. Dignity Talk may provide a gentle means of facilitating important end-of-life conversations.

A Single Molecule Scaffold for the Maize Genome

PubMed Central

Zhou, Shiguo; Wei, Fusheng; Nguyen, John; Bechner, Mike; Potamousis, Konstantinos; Goldstein, Steve; Pape, Louise; Mehan, Michael R.; Churas, Chris; Pasternak, Shiran; Forrest, Dan K.; Wise, Roger; Ware, Doreen; Wing, Rod A.; Waterman, Michael S.; Livny, Miron; Schwartz, David C.

2009-01-01

About 85% of the maize genome consists of highly repetitive sequences that are interspersed by low-copy, gene-coding sequences. The maize community has dealt with this genomic complexity by the construction of an integrated genetic and physical map (iMap), but this resource alone was not sufficient for ensuring the quality of the current sequence build. For this purpose, we constructed a genome-wide, high-resolution optical map of the maize inbred line B73 genome containing >91,000 restriction sites (averaging 1 site/∼23 kb) accrued from mapping genomic DNA molecules. Our optical map comprises 66 contigs, averaging 31.88 Mb in size and spanning 91.5% (2,103.93 Mb/∼2,300 Mb) of the maize genome. A new algorithm was created that considered both optical map and unfinished BAC sequence data for placing 60/66 (2,032.42 Mb) optical map contigs onto the maize iMap. The alignment of optical maps against numerous data sources yielded comprehensive results that proved revealing and productive. For example, gaps were uncovered and characterized within the iMap, the FPC (fingerprinted contigs) map, and the chromosome-wide pseudomolecules. Such alignments also suggested amended placements of FPC contigs on the maize genetic map and proactively guided the assembly of chromosome-wide pseudomolecules, especially within complex genomic regions. Lastly, we think that the full integration of B73 optical maps with the maize iMap would greatly facilitate maize sequence finishing efforts that would make it a valuable reference for comparative studies among cereals, or other maize inbred lines and cultivars. PMID:19936062

An unfinished agenda on adolescent health: Opportunities for interventions.

PubMed

Lassi, Zohra S; Salam, Rehana A; Das, Jai K; Wazny, Kerri; Bhutta, Zulfiqar A

2015-08-01

The Millennium Development Goal era has resulted in improvements in maternal and child health worldwide. As more children are surviving past their fifth birthday, the population of adolescents is increasing. Adolescence is a time of significant developmental transition; adolescence sets the stage for adult health through risks taken and beneficial and detrimental habits that are formed and it is thus an optimal time to target health interventions. Beginning interventions in adolescence or even earlier in childhood maximizes the impact on the individual's health in adult life. Evidence suggests that interventions to promote sexual and reproductive health, physical activity and healthy lifestyle, mental health and wellbeing, safe and hazard-free environment, improving access to nutritious and healthy foods, and minimizing exposure to substance abuse can improve health outcomes in young adolescents. School-based delivery strategies appear to be the most highly evaluated for improving adolescent health; they have been used to deliver interventions such as sexual health, substance abuse prevention, and nutritional interventions. Use of social media and information technologies, cash transfers, social protection, and micro-finance initiatives are promising strategies; however, given the lack of rigorous evaluations, there is a need for further research. Additional research is also warranted to strengthen the evidence base by establishing causality, understanding the differential impacts of adolescent health in different contexts particularly in low- and middle-income countries. In addition, research and evaluation in the domain of adolescent health must focus on how to implement interventions effectively at-scale, sustain the impacts over time and ensure equitable outcomes. Copyright © 2015 Elsevier Inc. All rights reserved.

ISEA2007 panel: integration of better exposure characterizations into disaster preparedness for responders and the public.

PubMed

Rodes, Charles E; Pellizzari, Edo D; Dellarco, Michael J; Erickson, Mitchell D; Vallero, Daniel A; Reissman, Dori B; Lioy, Paul J; Lippmann, Morton; Burke, Thomas A; Goldstein, Bernard D

2008-11-01

An expert panel was convened in October 2007 at the International Society for Exposure Analysis Annual Meeting in Durham, NC, entitled "The Path Forward in Disaster Preparedness Since WTC-Exposure Characterization and Mitigation: Substantial Unfinished Business!" The panel prospectively discussed the critical exposure issues being overlooked during disaster responses and highlighted the needs for an optimal blending of exposure characterizations and hazard controls within disaster settings. The cases were made that effective and timely exposure characterizations must be applied during responses to any disaster, whether terrorist, manmade, or natural in origin. The consistent application of exposure sciences across acute and chronic disaster timelines will assure that the most effective strategies are applied to collect the needed information to guide risk characterization and management approaches. Exposure sciences must be effectively applied across all phases of a disaster (defined as rescue, reentry, recovery, and rehabitation-the four Rs) to appropriately characterize risks and guide risk-mitigation approaches. Failure to adequately characterize and control hazardous exposures increases the likelihood of excess morbidity and mortality. Advancing the infrastructure and the technologies to collect the right exposure information before, during, and immediately after disasters would advance our ability to define risks and protect responders and the public better. The panel provided conclusions, recommendations, and next steps toward effective and timely integration of better exposure science into disaster preparedness, including the need for a subsequent workshop to facilitate this integration. All panel presentations and a summary were uploaded to the ISES(1) website (http://www.iseaweb.org/Disaster_Preparedness/index.php).

Recognising and responding to 'cutting corners' when providing nursing care: a qualitative study.

PubMed

Jones, Angela; Johnstone, Megan-Jane; Duke, Maxine

2016-08-01

The aim of this study is to report on a key finding of a larger study investigating the 'gaps' in patient care that registered nurses encounter during the course of their practice. A key finding of this larger study was that 'cutting corners' was a gap discerned by nurses. 'Cutting corners' has been characterised as a 'violation' and threat to patient safety, although there is a paucity of research on this issue. Naturalistic inquiry using a qualitative exploratory descriptive approach. Data were collected from a purposeful sample of 71 registered nurses from emergency department, critical care, perioperative, rehabilitation and transitional care and neurosciences settings in Australia and analysed using content and thematic analysis strategies. Cutting corners was a common practice that encompassed (1) the partial or complete omission of patient care, (2) delays in providing care and (3) the failure to do things correctly. Corners were cut in patient assessment, essential nursing care, the care of central venous catheters and medication administration. The practice of cutting corners was perceived as contributing to preventable adverse events. The study found that cutting corners created gaps that contributed to unfinished nursing care and preventable adverse events. The findings of the study raise the possibility that cutting corners is a salient but underinvestigated characteristic of nursing practice. Further research and inquiry are needed to deepen understanding of cutting corners and its impact on patient safety. Identifying the nature and implications of cutting corners when providing nursing care is an important contributing factor to improving patient safety and quality care. © 2016 John Wiley & Sons Ltd.

What the History of Drugs Can Teach Us About the Current Cannabis Legalization Process: Unfinished Business.

PubMed

Adrian, Manuella

2015-01-01

Over time, there have been considerable changes in the variety, availability, production, distribution, and use and user(s) of psychoactive substances, the meaning of substance use and its impact on users and their social or physical environment(s). This article reviews the mechanisms of introduction of psychoactive substances such as alcohol, tobacco, coffee, tea and cannabis to populations and communities that did not have them before. It considers the historical tension between early adopters who greet new substances with various levels of enthusiasm in their eagerness to enjoy what they believe to be the benefits of using these substances, and those focused on what they believe to be the negative aspects of use, who decry these new substances with horror. With more nonusers than users in the population, social policies tend to be directed at preventing, restricting, or punishing selected use, users and .drugs., using controls and interventions such regulation, incarceration, death sentence, treatment, prevention, legalization, taxation, among others. Whatever their intent or wished-for impact, all had consequences that produced additional, unplanned for, and (often) negative effects. This paper will consider some of these sequences as they occurred historically with other substances in light of the current shift to legalization and normalization of cannabis, noting the mechanisms of use, controls, and consequences of some types of formal interventions and give some attention to how and what we can learn from our experiences in order to plan ahead and become better prepared to successfully deal with the 'unexpecteds' of that well-known 'hell' paved with good intentions.

A Bayesian CUSUM plot: Diagnosing quality of treatment.

PubMed

Rosthøj, Steen; Jacobsen, Rikke-Line

2017-12-01

To present a CUSUM plot based on Bayesian diagnostic reasoning displaying evidence in favour of "healthy" rather than "sick" quality of treatment (QOT), and to demonstrate a technique using Kaplan-Meier survival curves permitting application to case series with ongoing follow-up. For a case series with known final outcomes: Consider each case a diagnostic test of good versus poor QOT (expected vs. increased failure rates), determine the likelihood ratio (LR) of the observed outcome, convert LR to weight taking log to base 2, and add up weights sequentially in a plot showing how many times odds in favour of good QOT have been doubled. For a series with observed survival times and an expected survival curve: Divide the curve into time intervals, determine "healthy" and specify "sick" risks of failure in each interval, construct a "sick" survival curve, determine the LR of survival or failure at the given observation times, convert to weights, and add up. The Bayesian plot was applied retrospectively to 39 children with acute lymphoblastic leukaemia with completed follow-up, using Nordic collaborative results as reference, showing equal odds between good and poor QOT. In the ongoing treatment trial, with 22 of 37 children still at risk for event, QOT has been monitored with average survival curves as reference, odds so far favoring good QOT 2:1. QOT in small patient series can be assessed with a Bayesian CUSUM plot, retrospectively when all treatment outcomes are known, but also in ongoing series with unfinished follow-up. © 2017 John Wiley & Sons, Ltd.

A new flux-limited, two-dimensional, nonsymmetric tensor shock viscosity for DYNA2D: Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, D.J.

1988-08-15

A new artificial viscosity that is being developed for DYNA2D is described in this progress report. It incorporates the one- dimensional, flux-limited viscosity developed by Randy Christensen into a two-dimensional setting. In addition, it tries to overcome some of the difficulties associated with traditional bulk viscosity formulations by using an nonsymmetric viscosity tensor. A different nonsymmetric approach (and a symmetrized version of it) is being used in SHALE by Len Margolin with great success. In a later section of this paper, the results of DYNA2D and SHALE for the ''Saltzman problem'' are compared. The general organization of this report ismore » as follows: First it presents the one-dimensional, flux-limited viscosity developed by Christensen. An nonsymmetric tensor viscosity is then developed and the addition of flux-limiting to it is discussed. The issue of boundary conditions turns out to be crucial, and some issues associated with them are unresolved. The current boundary conditions and the issues associated with them are discussed. Example calculations are also given. The current work is summarized and future work is outlined in the first chapter. This brief progress report is the basis of a future journal paper. The work presented in here is unfinished, and some of the results and algorithms will undoubtedly be changed before the final paper. No attempt has been made to survey the results of others in this report, but a limited survey will be incorporated in the journal paper. 7 refs., 39 figs.« less

A computational chemistry perspective on the current status and future direction of hepatitis B antiviral drug discovery.

PubMed

Morgnanesi, Dante; Heinrichs, Eric J; Mele, Anthony R; Wilkinson, Sean; Zhou, Suzanne; Kulp, John L

2015-11-01

Computational chemical biology, applied to research on hepatitis B virus (HBV), has two major branches: bioinformatics (statistical models) and first-principle methods (molecular physics). While bioinformatics focuses on statistical tools and biological databases, molecular physics uses mathematics and chemical theory to study the interactions of biomolecules. Three computational techniques most commonly used in HBV research are homology modeling, molecular docking, and molecular dynamics. Homology modeling is a computational simulation to predict protein structure and has been used to construct conformers of the viral polymerase (reverse transcriptase domain and RNase H domain) and the HBV X protein. Molecular docking is used to predict the most likely orientation of a ligand when it is bound to a protein, as well as determining an energy score of the docked conformation. Molecular dynamics is a simulation that analyzes biomolecule motions and determines conformation and stability patterns. All of these modeling techniques have aided in the understanding of resistance mutations on HBV non-nucleos(t)ide reverse-transcriptase inhibitor binding. Finally, bioinformatics can be used to study the DNA and RNA protein sequences of viruses to both analyze drug resistance and to genotype the viral genomes. Overall, with these techniques, and others, computational chemical biology is becoming more and more necessary in hepatitis B research. This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B." Copyright © 2015 Elsevier B.V. All rights reserved.

Efficient identification of Y chromosome sequences in the human and Drosophila genomes.

PubMed

Carvalho, Antonio Bernardo; Clark, Andrew G

2013-11-01

Notwithstanding their biological importance, Y chromosomes remain poorly known in most species. A major obstacle to their study is the identification of Y chromosome sequences; due to its high content of repetitive DNA, in most genome projects, the Y chromosome sequence is fragmented into a large number of small, unmapped scaffolds. Identification of Y-linked genes among these fragments has yielded important insights about the origin and evolution of Y chromosomes, but the process is labor intensive, restricting studies to a small number of species. Apart from these fragmentary assemblies, in a few mammalian species, the euchromatic sequence of the Y is essentially complete, owing to painstaking BAC mapping and sequencing. Here we use female short-read sequencing and k-mer comparison to identify Y-linked sequences in two very different genomes, Drosophila virilis and human. Using this method, essentially all D. virilis scaffolds were unambiguously classified as Y-linked or not Y-linked. We found 800 new scaffolds (totaling 8.5 Mbp), and four new genes in the Y chromosome of D. virilis, including JYalpha, a gene involved in hybrid male sterility. Our results also strongly support the preponderance of gene gains over gene losses in the evolution of the Drosophila Y. In the intensively studied human genome, used here as a positive control, we recovered all previously known genes or gene families, plus a small amount (283 kb) of new, unfinished sequence. Hence, this method works in large and complex genomes and can be applied to any species with sex chromosomes.

Academic and Resident Radiation Oncologists' Attitudes and Intentions Regarding Radiation Therapy near the End of Life.

PubMed

Lloyd, Shane; Dosoretz, Arie P; Yu, James B; Evans, Suzanne B; Decker, Roy H

2016-02-01

There has been increasing scrutiny about cancer treatment for patients very near the end of life (EoL), yet a substantial number receive palliative radiation therapy (RT) in this setting. Our aim was to document the attitudes and intentions of thought leaders and trainees in giving RT near the EoL. We distributed an anonymous survey to 473 radiation oncologists and residents. The survey examined the clinical and psychosocial factors considered as well as intentions and expectations in the delivery of RT near the EoL. Factors surrounding unfinished treatment courses, and the formative factors that shape opinions about RT at the EoL were also explored. We received 139 responses (29%). Eighty-nine percent of respondents worked at academic institutions. The factors that respondents most often consider very or extremely important to offer RT near the EoL were the preference of the patient to be treated (94%), the ability to tolerate treatment (88%), and palliative intent (70%). After instances when their patients were unable to complete treatment near the EoL, 42% of respondents said they would prescribe a shorter treatment the next time they see a similar patient. Personal experience (71%) was most often listed as very or extremely important in shaping their opinions about RT near the EoL. Survey respondents, 89% of whom were academic radiation oncologists, have a positive view of palliative RT near the EoL. They favor shorter fractionation for patients near the EoL. Personal experience is most important in shaping practices and attitudes.

Long-term quality assurance of [(18)F]-fluorodeoxyglucose (FDG) manufacturing.

PubMed

Gaspar, Ludovit; Reich, Michal; Kassai, Zoltan; Macasek, Fedor; Rodrigo, Luis; Kruzliak, Peter; Kovac, Peter

2016-01-01

Nine years of experience with 2286 commercial synthesis allowed us to deliver comprehensive information on the quality of (18)F-FDG production. Semi-automated FDG production line using Cyclone 18/9 machine (IBA Belgium), TRACERLab MXFDG synthesiser (GE Health, USA) using alkalic hydrolysis, grade "A" isolator with dispensing robotic unit (Tema Sinergie, Italy), and automatic control system under GAMP5 (minus2, Slovakia) was assessed by TQM tools as highly reliable aseptic production line, fully compliant with Good Manufacturing Practice and just-in-time delivery of FDG radiopharmaceutical. Fluoride-18 is received in steady yield and of very high radioactive purity. Synthesis yields exhibited high variance connected probably with quality of disposable cassettes and chemicals sets. Most performance non-conformities within the manufacturing cycle occur at mechanical nodes of dispensing unit. The long-term monitoring of 2286 commercial synthesis indicated high reliability of automatic synthesizers. Shewhart chart and ANOVA analysis showed that minor non-compliances occurred were mostly caused by the declinations of less experienced staff from standard operation procedures, and also by quality of automatic cassettes. Only 15 syntheses were found unfinished and in 4 cases the product was out-of-specification of European Pharmacopoeia. Most vulnerable step of manufacturing was dispensing and filling in grade "A" isolator. Its cleanliness and sterility was fully controlled under the investigated period by applying hydrogen peroxide vapours (VHP). Our experience with quality assurance in the production of [(18)F]-fluorodeoxyglucose (FDG) at production facility of BIONT based on TRACERlab MXFDG production module can be used for bench-marking of the emerging manufacturing and automated manufacturing systems.

Necessity and benefits of physician assistants' participation in international clinical experiences.

PubMed

Kibe, Lucy Wachera

2012-01-01

Several consultation stations have been set up in an unfinished stone building. My team is made up of a Kenyan physician assistant (called clinical officer), a Kenyan medical student, and me, a US physician assistant student. We are huddled around a small worn-out square table. A middle-aged woman and her two children, ages 2 and 6, approach the table. They have traveled 2 miles to the medical camp. The children, covered in dust, are emaciated with protruding abdomens, dry skin, and congested noses. The clinical officer (CO) conducts a brief interview in Swahili, the Kenyan national language. The mother explains that they have been coughing up thick yellow sputum for a week and have no appetite. They've also had diarrhea for a couple of weeks. I examine the children, who are obviously scared. Hot, moist skin. They are both running a fever. I listen to the lungs: reduced lung sounds. The protruding abdomens are rock hard. I report the findings to the team. The CO turns to the Kenyan medical student and me and quizzes us on differential diagnoses with rationale for each. We come up with malaria, pneumonia, TB, and worm infestation. Due to limited resources, medical diagnosis in Kenya relies heavily on history and physical exam. The CO explains that comorbid conditions are probable. Luckily, we have malaria-testing kits at the camp. They test negative for malaria. We decide to treat them for pneumonia. We also offer them a free hot meal, toothbrushes, T-shirts, coloring paper, and crayons. The children manage to smile. The mother is so grateful, she cries.

Long-term quality assurance of [18F]-fluorodeoxyglucose (FDG) manufacturing

PubMed Central

Gaspar, Ludovit; Reich, Michal; Kassai, Zoltan; Macasek, Fedor; Rodrigo, Luis; Kruzliak, Peter; Kovac, Peter

2016-01-01

Nine years of experience with 2286 commercial synthesis allowed us to deliver comprehensive information on the quality of 18F-FDG production. Semi-automated FDG production line using Cyclone 18/9 machine (IBA Belgium), TRACERLab MXFDG synthesiser (GE Health, USA) using alkalic hydrolysis, grade “A” isolator with dispensing robotic unit (Tema Sinergie, Italy), and automatic control system under GAMP5 (minus2, Slovakia) was assessed by TQM tools as highly reliable aseptic production line, fully compliant with Good Manufacturing Practice and just-in-time delivery of FDG radiopharmaceutical. Fluoride-18 is received in steady yield and of very high radioactive purity. Synthesis yields exhibited high variance connected probably with quality of disposable cassettes and chemicals sets. Most performance non-conformities within the manufacturing cycle occur at mechanical nodes of dispensing unit. The long-term monitoring of 2286 commercial synthesis indicated high reliability of automatic synthesizers. Shewhart chart and ANOVA analysis showed that minor non-compliances occurred were mostly caused by the declinations of less experienced staff from standard operation procedures, and also by quality of automatic cassettes. Only 15 syntheses were found unfinished and in 4 cases the product was out-of-specification of European Pharmacopoeia. Most vulnerable step of manufacturing was dispensing and filling in grade “A” isolator. Its cleanliness and sterility was fully controlled under the investigated period by applying hydrogen peroxide vapours (VHP). Our experience with quality assurance in the production of [18F]-fluorodeoxyglucose (FDG) at production facility of BIONT based on TRACERlab MXFDG production module can be used for bench-marking of the emerging manufacturing and automated manufacturing systems. PMID:27508102

Development and evaluation of the Dignity Talk question framework for palliative patients and their families: A mixed-methods study

PubMed Central

Guo, Qiaohong; Chochinov, Harvey Max; McClement, Susan; Thompson, Genevieve; Hack, Tom

2017-01-01

Background: Effective patient–family communication can reduce patients’ psychosocial distress and relieve family members’ current suffering and their subsequent grief. However, terminally ill patients and their family members often experience great difficulty in communicating their true feelings, concerns, and needs to each other. Aim: To develop a novel means of facilitating meaningful conversations for palliative patients and family members, coined Dignity Talk, explore anticipated benefits and challenges of using Dignity Talk, and solicit suggestions for protocol improvement. Design: A convergent parallel mixed-methods design. Dignity Talk, a self-administered question list, was designed to prompt end-of-life conversations, adapted from the Dignity Therapy question framework. Participants were surveyed to evaluate the Dignity Talk question framework. Data were analyzed using qualitative and quantitative methods. Setting/participants: A total of 20 palliative patients, 20 family members, and 34 healthcare providers were recruited from two inpatient palliative care units in Winnipeg, Canada. Results: Most Dignity Talk questions were endorsed by the majority of patients and families (>70%). Dignity Talk was revised to be convenient and flexible to use, broadly accessible, clearly stated, and sensitively worded. Participants felt Dignity Talk would be valuable in promoting conversations, enhancing family connections and relationships, enhancing patient sense of value and dignity, promoting effective interaction, and attending to unfinished business. Participants suggested that patients and family members be given latitude to respond only to questions that are meaningful to them and within their emotional capacity to broach. Conclusion: Dignity Talk may provide a gentle means of facilitating important end-of-life conversations. PMID:29130367

Prevalence of Trypanosoma cruzi Infection among People Aged 15 to 89 Years Inhabiting the Department of Casanare (Colombia)

PubMed Central

Gutierrez, Fredy Roberto Salazar; Trujillo Güiza, Martha Liliana; Escobar Martínez, Magally del Carmen

2013-01-01

The purpose of this study was to calculate the seroprevalence of Trypanosoma cruzi infection in a sample of inhabitants from a region considered to be at high risk of natural transmission of Chagas disease in Colombia. A cross-sectional study was conducted in subjects from 5 municipalities, recruited in urban and rural locations, distributed by gender according to the demographic information available. Socio-demographic information, history of potential exposure to insect vectors, blood donating, as well as symptoms suggesting cardiac disease were collected using a questionnaire. After giving written informed consent, blood specimens were obtained from 486 people to determine the serologic evidence of past exposure to T. cruzi. Infection was diagnosed when two different tests (ELISA and IHA) were positive. The seroprevalence of antibodies against T. cruzi was 16.91% considering an estimated population of 44,355 aged between 15 and 89 years (95%IC: 13.72 to 20.01). The factors significantly associated with the infection were: 1- Housing materials like vegetable material, adobe or unfinished brick walls; 2- The fact of having previous tests for Chagas disease (regardless of the result). Of note, the mean ages among infected and not infected participants were significantly different (49.19 vs. 41.66, p≤0.0001). Among the studied municipalities, the one with the highest frequency of T. cruzi infection was Nunchia, with 31.15% of the surveyed subjects. Therefore it may be concluded that T. cruzi infection is highly prevalent in the north region of Casanare, in Colombia. PMID:23505592

The unfinished health agenda: Neonatal mortality in Cambodia.

PubMed

Hong, Rathmony; Ahn, Pauline Yongeun; Wieringa, Frank; Rathavy, Tung; Gauthier, Ludovic; Hong, Rathavuth; Laillou, Arnaud; Van Geystelen, Judit; Berger, Jacques; Poirot, Etienne

2017-01-01

Reduction of neonatal and under-five mortality rates remains a primary target in the achievement of universal health goals, as evident in renewed investments of Sustainable Development Goals. Various studies attribute declines in mortality to the combined effects of improvements in health care practices and changes in socio-economic factors. Since the early nineties, Cambodia has managed to evolve from a country devastated by war to a nation soon to enter the group of middle income countries. Cambodia's development efforts are reflected in some remarkable health outcomes such as a significant decline in child mortality rates and the early achievement of related Millennium Development Goals. An achievement acknowledged through the inclusion of Cambodia as one of the ten fast-track countries in the Partnership for Maternal, Newborn and Child Health. This study aims to highlight findings from the field so to provide evidence for future programming and policy efforts. It will be argued that to foster further advances in health, Cambodia will need to keep neonatal survival and health high on the agenda and tackle exacerbating inequities that arise from a pluralistic health system with considerable regional differences and socio-economic disparities. Data was drawn from Demographic Health Surveys (2000, 2005, 2010, 2014). Information on a series of demographic and socio-economic household characteristics and on child anthropometry, feeding practices and child health were collected from nationally representative samples. To reach the required sample size, live-births that occurred over the past 10 years before the date of the interview were included. Demographic variables included: gender of the child, living area (urban or rural; four ecological regions (constructed by merging provinces and the capital), mother's age at birth (<20, 20-35, 35+), birth interval (long, short) and birth order (1st, 2-3, 4-6, 7+). Socio-economic variables included: mother education level (none, primary, secondary+) and household wealth (asset-based index). Data on antenatal care, tetanus injection and skilled assistance at birth were used for the mother's last child. Between 2000 and 2014, Cambodia achieved a considerable reduction in neonatal mortality (46% reduction rate). By 2014, gender inequities became almost non-existent (for all measures of equality); inequity related to mother's education decreased for all time periods; improvements were observed for differences in neonatal mortality by preceding birth interval; and a reduction in neonatal mortality rates could be noted among all the regional subgroups. Inequities increased between mothers who had limited antenatal care and those who received more than four antenatal care visits. In most scale indicators, the Slope Index of Inequality and Relative Index of Inequality estimates for all four rounds of the survey suggest inequity exacerbated in deprived communities. Also, wealth and residence (urban/rural divide) continued to be major determinants in neonatal mortality rates and related inequity trends. Analysis highlighted some of the complex patterns and determinants of neonatal mortality, in Cambodia. There has been a considerable decline in neonatal mortality which echoes global trends. Our analysis reveals that despite these advances, additional socio-economic and demographic characteristics considerably affected neonatal mortality rates and its inequities. There continue to be pockets of vulnerable groups that are lagging behind. This analysis highlights the determinants along the urban-rural and rich-poor divides in neonatal mortality inequities and how these affect access to and utilization of quality basic health services. This calls for future policy and programming efforts to be deliberate in their equity approach. Quality improvements in health services and targeted interventions for specific socio-economic groups will be required to further accelerate progress in reducing neonatal mortality and address Cambodia's pressing unfinished agenda in health.

The unfinished health agenda: Neonatal mortality in Cambodia

PubMed Central

Hong, Rathmony; Ahn, Pauline Yongeun; Rathavy, Tung; Gauthier, Ludovic; Hong, Rathavuth; Laillou, Arnaud

2017-01-01

Background Reduction of neonatal and under-five mortality rates remains a primary target in the achievement of universal health goals, as evident in renewed investments of Sustainable Development Goals. Various studies attribute declines in mortality to the combined effects of improvements in health care practices and changes in socio-economic factors. Since the early nineties, Cambodia has managed to evolve from a country devastated by war to a nation soon to enter the group of middle income countries. Cambodia's development efforts are reflected in some remarkable health outcomes such as a significant decline in child mortality rates and the early achievement of related Millennium Development Goals. An achievement acknowledged through the inclusion of Cambodia as one of the ten fast-track countries in the Partnership for Maternal, Newborn and Child Health. This study aims to highlight findings from the field so to provide evidence for future programming and policy efforts. It will be argued that to foster further advances in health, Cambodia will need to keep neonatal survival and health high on the agenda and tackle exacerbating inequities that arise from a pluralistic health system with considerable regional differences and socio-economic disparities. Methods/Findings Data was drawn from Demographic Health Surveys (2000, 2005, 2010, 2014). Information on a series of demographic and socio-economic household characteristics and on child anthropometry, feeding practices and child health were collected from nationally representative samples. To reach the required sample size, live-births that occurred over the past 10 years before the date of the interview were included. Demographic variables included: gender of the child, living area (urban or rural; four ecological regions (constructed by merging provinces and the capital), mother’s age at birth (<20, 20–35, 35+), birth interval (long, short) and birth order (1st, 2–3, 4–6, 7+). Socio-economic variables included: mother education level (none, primary, secondary+) and household wealth (asset-based index). Data on antenatal care, tetanus injection and skilled assistance at birth were used for the mother's last child. Between 2000 and 2014, Cambodia achieved a considerable reduction in neonatal mortality (46% reduction rate). By 2014, gender inequities became almost non-existent (for all measures of equality); inequity related to mother’s education decreased for all time periods; improvements were observed for differences in neonatal mortality by preceding birth interval; and a reduction in neonatal mortality rates could be noted among all the regional subgroups. Inequities increased between mothers who had limited antenatal care and those who received more than four antenatal care visits. In most scale indicators, the Slope Index of Inequality and Relative Index of Inequality estimates for all four rounds of the survey suggest inequity exacerbated in deprived communities. Also, wealth and residence (urban/rural divide) continued to be major determinants in neonatal mortality rates and related inequity trends. Conclusion Analysis highlighted some of the complex patterns and determinants of neonatal mortality, in Cambodia. There has been a considerable decline in neonatal mortality which echoes global trends. Our analysis reveals that despite these advances, additional socio-economic and demographic characteristics considerably affected neonatal mortality rates and its inequities. There continue to be pockets of vulnerable groups that are lagging behind. This analysis highlights the determinants along the urban-rural and rich-poor divides in neonatal mortality inequities and how these affect access to and utilization of quality basic health services. This calls for future policy and programming efforts to be deliberate in their equity approach. Quality improvements in health services and targeted interventions for specific socio-economic groups will be required to further accelerate progress in reducing neonatal mortality and address Cambodia’s pressing unfinished agenda in health. PMID:28323854

Elimination of Neglected Diseases in Latin America and the Caribbean: A Mapping of Selected Diseases

PubMed Central

Schneider, Maria Cristina; Aguilera, Ximena Paz; Barbosa da Silva Junior, Jarbas; Ault, Steven Kenyon; Najera, Patricia; Martinez, Julio; Requejo, Raquel; Nicholls, Ruben Santiago; Yadon, Zaida; Silva, Juan Carlos; Leanes, Luis Fernando; Periago, Mirta Roses

2011-01-01

In Latin America and the Caribbean, around 195 million people live in poverty, a situation that increases the burden of some infectious diseases. Neglected diseases, in particular, are often restricted to poor, marginalized sections of the population. Tools exist to combat these diseases, making it imperative to work towards their elimination. In 2009, the Pan American Health Organization (PAHO) received a mandate to support the countries in the Region in eliminating neglected diseases and other poverty-related infections. The objective of this study is to analyze the presence of selected diseases using geo-processing techniques. Five diseases with information available at the first sub-national level (states) were mapped, showing the presence of the disease (“hotspots”) and overlap of diseases (“major hotspots”). In the 45 countries/territories (approximately 570 states) of the Region, there is: lymphatic filariasis in four countries (29 states), onchocerciasis in six countries (25 states), schistosomiasis in four countries (39 states), trachoma in three countries (29 states), and human rabies transmitted by dogs in ten countries (20 states). Of the 108 states with one or more of the selected diseases, 36 states present the diseases in overlapping areas (“major hotspots”). Additional information about soil-transmitted helminths was included. The analysis suggests a majority of the selected diseases are not widespread and can be considered part of an unfinished agenda with elimination as a goal. Integrated plans and a comprehensive approach, ensuring access to existing diagnostic and treatment methods, and establishing a multi-sectoral agenda that addresses social determinants, including access to adequate water and sanitation, are required. Future studies can include additional diseases, socio-economic and environmental variables. PMID:21358810

In silico Comparison of 19 Porphyromonas gingivalis Strains in Genomics, Phylogenetics, Phylogenomics and Functional Genomics.

PubMed

Chen, Tsute; Siddiqui, Huma; Olsen, Ingar

2017-01-01

Currently, genome sequences of a total of 19 Porphyromonas gingivalis strains are available, including eight completed genomes (strains W83, ATCC 33277, TDC60, HG66, A7436, AJW4, 381, and A7A1-28) and 11 high-coverage draft sequences (JCVI SC001, F0185, F0566, F0568, F0569, F0570, SJD2, W4087, W50, Ando, and MP4-504) that are assembled into fewer than 300 contigs. The objective was to compare these genomes at both nucleotide and protein sequence levels in order to understand their phylogenetic and functional relatedness. Four copies of 16S rRNA gene sequences were identified in each of the eight complete genomes and one in the other 11 unfinished genomes. These 43 16S rRNA sequences represent only 24 unique sequences and the derived phylogenetic tree suggests a possible evolutionary history for these strains. Phylogenomic comparison based on shared proteins and whole genome nucleotide sequences consistently showed two groups with closely related members: one consisted of ATCC 33277, 381, and HG66, another of W83, W50, and A7436. At least 1,037 core/shared proteins were identified in the 19 P. gingivalis genomes based on the most stringent detecting parameters. Comparative functional genomics based on genome-wide comparisons between NCBI and RAST annotations, as well as additional approaches, revealed functions that are unique or missing in individual P. gingivalis strains, or species-specific in all P. gingivalis strains, when compared to a neighboring species P. asaccharolytica . All the comparative results of this study are available online for download at ftp://www.homd.org/publication_data/20160425/.

The Lvov-Warsaw School: The forgotten tradition of historical psychology.

PubMed

Citlak, Amadeusz

2016-05-01

This article is an attempt to reconstruct the psychological achievements of the representatives of the Lvov-Warsaw School of historical psychology, virtually forgotten and unknown in the world's psychological literature. Kazimierz Twardowski (1866-1938), founder of the school, developed a philosophical and psychological program on the basis of (among other things) the theory of actions and products, including the research program that is now included in the thread of historical psychology. His student, Wladyslaw Witwicki (1878-1948), developed the cratism theory (the theory of power) on the basis Twardowski's assumptions, providing an alternative to Alfred Adler's theory of striving for superiority while also declaring it a few years before Adler. The consequence of Witwicki's theory and the methodological assumptions was the creation of psychobiography: the first nonpsychoanalytical psychobiography of Socrates (Witwicki, 1909, 1922) and the psychobiography of Jesus Christ (Witwicki, 1958). The school's activities weakened for political reasons, particularly the outbreak of the First World War. The members of the school dispersed after 1918, and they lost international connections with the world of science. Their significant achievements in the field of psychology remained unknown to psychologists for nearly a century. In this article, I would like to present the school's unique but unfinished program of reconstructing mental life through the psychological interpretation of cultural products (literature, arts, diaries), and its value for the practice of research in historical psychology. This program required additional development, but because of the war this never happened. Some of the school's theoretical findings and the first attempts to apply them have still significant value and show us the originality of Lvov-Warsaw School psychology. (c) 2016 APA, all rights reserved).

Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163T and comparative genomic insights into plant pathogenicity

PubMed Central

2010-01-01

Background Erwinia pyrifoliae is a newly described necrotrophic pathogen, which causes fire blight on Asian (Nashi) pear and is geographically restricted to Eastern Asia. Relatively little is known about its genetics compared to the closely related main fire blight pathogen E. amylovora. Results The genome of the type strain of E. pyrifoliae strain DSM 12163T, was sequenced using both 454 and Solexa pyrosequencing and annotated. The genome contains a circular chromosome of 4.026 Mb and four small plasmids. Based on their respective role in virulence in E. amylovora or related organisms, we identified several putative virulence factors, including type III and type VI secretion systems and their effectors, flagellar genes, sorbitol metabolism, iron uptake determinants, and quorum-sensing components. A deletion in the rpoS gene covering the most conserved region of the protein was identified which may contribute to the difference in virulence/host-range compared to E. amylovora. Comparative genomics with the pome fruit epiphyte Erwinia tasmaniensis Et1/99 showed that both species are overall highly similar, although specific differences were identified, for example the presence of some phage gene-containing regions and a high number of putative genomic islands containing transposases in the E. pyrifoliae DSM 12163T genome. Conclusions The E. pyrifoliae genome is an important addition to the published genome of E. tasmaniensis and the unfinished genome of E. amylovora providing a foundation for re-sequencing additional strains that may shed light on the evolution of the host-range and virulence/pathogenicity of this important group of plant-associated bacteria. PMID:20047678

Factors contributing to nursing task incompletion as perceived by nurses working in Kuwait general hospitals.

PubMed

Al-Kandari, Fatimah; Thomas, Deepa

2009-12-01

Unfinished care has a strong relationship with quality of nursing care. Most issues related to tasks incompletion arise from staffing and workload. This study was conducted to assess the workload of nurses, the nursing activities (tasks) nurses commonly performed on medical and surgical wards, elements of nursing care activities left incomplete by nurses during a shift, factors contributing to task incompletion and the relationship between staffing, demographic variables and task incompletion. Exploratory survey using a self-administered questionnaire developed from IHOC survey, USA. All full time registered nurses working on the general medical and surgical wards of five government general hospitals in Kuwait. Research assistants distributed and collected back the questionnaires. Four working days were given to participants to complete and return the questionnaires. A total of 820 questionnaires were distributed and 95% were returned. Descriptive and inferential analysis using SPSS-11. The five most frequently performed nursing activities were: administration of medications, assessing patient condition, preparing/updating nursing care plans, close patient monitoring and client health teaching. The most common nursing activities nurses were unable to complete were: comfort talk with patient and family, adequate documentation of nursing care, oral hygiene, routine catheter care and starting or changing IV fluid on time. Tasks were more complete when the nurse-patient load was less than 5. Nurses' age and educational background influenced task completion while nurses' gender had no influence on it. Increased patient loads, resulting in increased frequency of nursing tasks and non-nursing tasks, were positively correlated to incompletion of nursing activities during the shift. Emphasis should be given to maintaining the optimum nurse-patient load and decreasing the non-nursing workload of nurses to enhance the quality of nursing care.

Finding the right doctoral thesis - an innovative research fair for medical students.

PubMed

Steffen, Julius; Grabbert, Markus; Pander, Tanja; Gradel, Maximilian; Köhler, Lisa-Maria; Fischer, Martin R; von der Borch, Philip; Dimitriadis, Konstantinos

2015-01-01

The importance of research, as promoted by the CanMEDS framework, is widely acknowledged. Many medical students in Germany work on a research project as part of their doctoral thesis whilst still going to medical school. However, a significant amount of projects are abandoned unfinished, which leads to substantial wastage of resources. One reason for this is an information deficit concerning undergraduate research projects. To counteract this, we introduced an annual event at LMU Munich called DoktaMed with more than 600 visitors each year. It combines medical convention and research fair including keynote lectures, workshops and poster sessions as well as an exhibition of research groups and institutes. DoktaMed is a peer-to-peer event organized by a team of 40 students. A needs analysis before its implementation underlined the information deficit as a possible cause for the high rate of abandoned projects. In the annual evaluation, visitors of DoktaMed rate the event with an average grade of 2.1 on a six-level Likert scale (n=558, SD=1.06, with "1=very good", "6=poor"). They stated to now feel better informed about the topic and regarded visiting DoktaMed as a worthwhile investment of time. Students are generally satisfied with the event and feel better informed after visiting DoktaMed. However, many students never visit DoktaMed for various reasons. A possible improvement would be to present a greater number of clinical studies in addition to the laboratory work that DoktaMed focuses on now. Evaluation after six years of DoktaMed is very promising. Visitors seem to be better informed. Nevertheless there is space for improvement in order to get more students and more faculty members involved. More studies are needed to assess long-term effects.

Artificial intelligence and the future.

PubMed

Clocksin, William F

2003-08-15

We consider some of the ideas influencing current artificial-intelligence research and outline an alternative conceptual framework that gives priority to social relationships as a key component and constructor of intelligent behaviour. The framework starts from Weizenbaum's observation that intelligence manifests itself only relative to specific social and cultural contexts. This is in contrast to a prevailing view, which sees intelligence as an abstract capability of the individual mind based on a mechanism for rational thought. The new approach is not based on the conventional idea that the mind is a rational processor of symbolic information, nor does it require the idea that thought is a kind of abstract problem solving with a semantics that is independent of its embodiment. Instead, priority is given to affective and social responses that serve to engage the whole agent in the life of the communities in which it participates. Intelligence is seen not as the deployment of capabilities for problem solving, but as constructed by the continual, ever-changing and unfinished engagement with the social group within the environment. The construction of the identity of the intelligent agent involves the appropriation or 'taking up' of positions within the conversations and narratives in which it participates. Thus, the new approach argues that the intelligent agent is shaped by the meaning ascribed to experience, by its situation in the social matrix, and by practices of self and of relationship into which intelligent life is recruited. This has implications for the technology of the future, as, for example, classic artificial intelligence models such as goal-directed problem solving are seen as special cases of narrative practices instead of as ontological foundations.

Formative research: pretesting, revising, and more pretesting.

PubMed

Zimmerman, M; Steckel, L

1985-01-01

Thorough and extensive pretesting is the formative research technique that the Program for the Introduction and Adaptation of Contraceptive Technology (PIACT) and its sister organization, the Program for Appropriate Technology in Health (PATH), rely on to develop well-understood and culturally appropriate print materials. Formative research is defined as evaluation activities that occur during a project to determine if the objectives are being met and, if not, to modify the project's direction to ensure that they are. Before materials are finalized or printed, an interviewer should pretest them with representatives of the target population to determine if the intended message is being conveyed and if it is clear and acceptable to them. Pretesting should be done while the materials are still in an unfinished state so audience-generated alterations can be made easily. Revised materials also should be tested until they communicate the inforamtion as intended. Due to the fact that PIACT/PATH work with countries where large percentages of the population are illiterate, its motivational and instructional materials rely on pictures to convey the message. Often, pictures are augmented by a line or 2 of simple text in the local language. This text also requires careful pretesting. Examples from the field demonstrate the importance of pretesting to assure that print materials are appropriate to the group for whom they are being developed. The examples deal with sympbols, positive messages, the use of common objects, extraneous detail, messages about time, and text. Through pretesting, PIACT/PATH has learned that there can be a large discrepancy between what materials developers intend to convey and what the audience understands. Pretesting is an essential formative technique that builds upon information gathered during the materials development process, ensuring the message designer that the materials will effectively address the needs of the target audience.

In silico Comparison of 19 Porphyromonas gingivalis Strains in Genomics, Phylogenetics, Phylogenomics and Functional Genomics

PubMed Central

Chen, Tsute; Siddiqui, Huma; Olsen, Ingar

2017-01-01

Currently, genome sequences of a total of 19 Porphyromonas gingivalis strains are available, including eight completed genomes (strains W83, ATCC 33277, TDC60, HG66, A7436, AJW4, 381, and A7A1-28) and 11 high-coverage draft sequences (JCVI SC001, F0185, F0566, F0568, F0569, F0570, SJD2, W4087, W50, Ando, and MP4-504) that are assembled into fewer than 300 contigs. The objective was to compare these genomes at both nucleotide and protein sequence levels in order to understand their phylogenetic and functional relatedness. Four copies of 16S rRNA gene sequences were identified in each of the eight complete genomes and one in the other 11 unfinished genomes. These 43 16S rRNA sequences represent only 24 unique sequences and the derived phylogenetic tree suggests a possible evolutionary history for these strains. Phylogenomic comparison based on shared proteins and whole genome nucleotide sequences consistently showed two groups with closely related members: one consisted of ATCC 33277, 381, and HG66, another of W83, W50, and A7436. At least 1,037 core/shared proteins were identified in the 19 P. gingivalis genomes based on the most stringent detecting parameters. Comparative functional genomics based on genome-wide comparisons between NCBI and RAST annotations, as well as additional approaches, revealed functions that are unique or missing in individual P. gingivalis strains, or species-specific in all P. gingivalis strains, when compared to a neighboring species P. asaccharolytica. All the comparative results of this study are available online for download at ftp://www.homd.org/publication_data/20160425/. PMID:28261563

Long-Term Endovascular Treatment Outcome of 46 Patients with Cavernous Sinus Dural Arteriovenous Fistulas Presenting with Ophthalmic Symptoms

PubMed Central

Pashapour, Ali; Mohammadian, Reza; Salehpour, Firooz; Sharifipour, Ehsan; Mansourizade, Reza; Mahdavifard, Ali; Salehi, Mohamadgharib; Mirzaii, Farhad; Sariaslani, Payam; Fatahzade Ardalani, Ghasem; Altafi, Davar

2014-01-01

Summary Ocular symptoms are regularly observed in patients with cavernous sinus dural arteriovenous fistulas (cDAVF). We aimed to evaluate the long-term efficacy and safety of endovascular approaches in patients with cDAVF presenting with different ocular symptoms. In a prospective study between June 2008 and March 2013, 46 patients with ocular symptoms due to cDAVF who were not eligible for conservative therapy, met the inclusion criteria and underwent endovascular treatment. They underwent a transarterial approach with histoacryl glue injections or transvenous coil embolization, all in one session. They were followed up for a mean period of 17.3 months (range 7 to 30 months) clinically and using angiography. The mean age of patients was 36.8 years (18-60) and 65% of them were male. All patients showed venous drainage into the superior and inferior orbital veins. Access to the cavernous sinus was transvenous in ten patients, transarterial in 26 patients, and mixed in ten patients. Initial symptoms were improved in 97.8% of patients and did not recur during the study follow-up. The procedural complications included: blurred vision, transient sixth nerve palsy and exacerbation of chemoproptosis in two, one and two patients respectively that completely resolved in initial weeks with no recurrence. No patient worsened or developed new symptoms suggestive of a recurrent fistula during the follow-up period. One patient experienced intracranial dissection of the internal carotid artery and ischemic stroke with an unfinished procedure. The relief of early presentation was durable in long-term follow-up and the cured lesions were stable in angiographic controls. Favorable and durable outcomes could be obtained following endovascular approaches for cDAVF presenting with different ocular symptoms. PMID:25196621

Dynamic growth of slip surfaces in catastrophic landslides

PubMed Central

Germanovich, Leonid N.; Kim, Sihyun; Puzrin, Alexander M.

2016-01-01

This work considers a landslide caused by the shear band that emerges along the potential slip (rupture) surface. The material above the band slides downwards, causing the band to grow along the slope. This growth may first be stable (progressive), but eventually becomes dynamic (catastrophic). The landslide body acquires a finite velocity before it separates from the substrata. The corresponding initial-boundary value problem for a dynamic shear band is formulated within the framework of Palmer & Rice's (Proc. R. Soc. Lond. A 332, 527–548. (doi:10.1098/rspa.1973.0040)) approach, which is generalized to the dynamic case. We obtain the exact, closed-form solution for the band velocity and slip rate. This solution assesses when the slope fails owing to a limiting condition near the propagating tip of the shear band. Our results are applicable to both submarine and subaerial landslides of this type. It appears that neglecting dynamic (inertia) effects can lead to a significant underestimation of the slide size, and that the volumes of catastrophic slides can exceed the volumes of progressive slides by nearly a factor of 2. As examples, we consider the Gaviota and Humboldt slides offshore of California, and discuss landslides in normally consolidated sediments and sensitive clays. In particular, it is conceivable that Humboldt slide is unfinished and may still displace a large volume of sediments, which could generate a considerable tsunami. We show that in the case of submarine slides, the effect of water resistance on the shear band dynamics may frequently be limited during the slope failure stage. For a varying slope angle, we formulate a condition of slide cessation. PMID:26997904

Did poor eyesight influence Goya's late works? Medicine and art history in search for an interpretation of Goya's late paintings.

PubMed

Pérez-Trullén, José M; Ascaso, Francisco J; Auría, María J

2018-04-15

The aim of this article is to 'determine' the scope of Goya's eyesight difficulties and assess the extent to which those difficulties might explain his style of painting in the last years of his life. We analyse the correspondence and late works of the Aragonese painter Francisco de Goya y Lucientes (1746-1828), who has been admired for his use of colour, his energetic loose brushstrokes, his disregard for details and his bold compositions, as well as for his different artistic styles throughout his life. The evolution of Goya's style of painting in his later works seems to have been the consequence of an eyesight condition, probably age-related cataracts at an advanced stage. The faded dark backgrounds, which become blurred with the silhouette of the person portrayed, could indicate a certain degree of eye strain. This can be traced in all these works, but is especially evident in the unfinished portrait of Pío de Molina (1827-1828), as well as in the portraits of Mariano Goya, the artist's grandson (1827), and Jacques Galos (1826). It has been considered that the late and isolated Goya's sight problems were a belated consequence of his severe illness of 1792. Nevertheless, in our opinion, this is a simplistic explanation and, given the painter's age, it is logical to presume that their cause could be age-related lens opacities. This article argues that medicine may become a subsidiary science to art history, as it can provide empirical evidence of the way painters' illnesses may have a strong impact on their artworks. © 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Doing gender/teaching science: A feminist poststructural analysis of middle school science teachers' identity negotiations

NASA Astrophysics Data System (ADS)

Sowell, Scott P.

This research joins the gender equity conversation within science education by providing a feminist poststructural analysis of teachers' doing gender and teaching science. Feminist poststructuralism is used in recognition of the oppressive nature of dualistic modes of thought, which often reduce reality into a limiting either/or fallacy and can be theoretically constraining as research within any particular field becomes more sophisticated. By uprooting the concept of gendered identity from the unproductive grip of essentialism, and conceptualizing it instead as a shifting 'work in progress,' feminist poststructuralism provides an invigorating theoretical framework from which to conduct inquiries. From a this perspective, the identity of a teacher, as any identity, is not a fixed entity, but rather an unfinished project, swarmed upon by a variety of competing discourses. Situated in a rural middle school in the Florida panhandle, this research explores how numerous discourses compete to define what it means to be a female science teacher. More specifically, the aims of this research are to explore: (a) how the participants negotiated successful gendered identities within science and (b) how this taking up of subject positions crystallized into classroom practices which worked to reproduce and/or challenge commonsense notions of the heteropatriarchal gender dualism as well as the enmeshment of masculinity and science. Findings illustrate a wide array of classroom pedagogical practices, ranging from antioppressive emancipatory constructions of both gender and science to more traditional objectivist constructions that validated the patriarchal status quo. Explicating teacher identity as effects of these pedagogical approaches proved insightful in unveiling notions of resistance, frustration, enthusiasm, and agency as the teachers reflected on their practice.

Health, equity and the post-2015 agenda: raising the voices of marginalized communities.

PubMed

Ruano, Ana Lorena; Friedman, Eric A; Hill, Peter S

2014-10-10

In September 2012 the United Nations (UN) initiated a process that would extend and enhance the unfinished agenda of the Millennium Development Goals (MDGs), integrating a new vision for sustainable development beyond the year 2015. The initial consultation phase has been completed, with the UN and partner organizations undertaking eleven thematic consultations, including one on health. It is in this context that the European Commission (EC) has tasked the research consortium Goals and Governance for Global Health (Go4Health) with providing recommendations for the post-2015 health-related development goals and including voices that are routinely excluded from health-related decision-making processes. This has not been an easy task. It has led us to question how to define marginalization, how to access marginalized communities, as well as how community members could provide informed consent. The context of the communities we worked with was far removed from the reality of the post-2015 debates, where the MDGs and the new goals are remote and abstract, and where the promise of immediate benefit from participation could not be assured. Given the social, historical, cultural, ethnic and geographical diversity of our chosen community partners, and the diversity of their lived experiences, could their unique situations be generalized in ways that could influence the global debate? In this special issue, we have tried to explore the uniqueness and the commonalities of the issues and barriers that marginalized communities face all over the globe, and present them in individual papers that, together, provide a nuanced and complex picture of the challenges that face the post-2015 health-related agenda setting-process.

Intended and unintended consequences of abortion law reform: perspectives of abortion experts in Victoria, Australia.

PubMed

Keogh, L A; Newton, D; Bayly, C; McNamee, K; Hardiman, A; Webster, A; Bismark, M

2017-01-01

In Victoria, Australia, abortion was decriminalised in October 2008, bringing the law in line with clinical practice and community attitudes. We describe how experts in abortion service provision perceived the intent and subsequent impact of the 2008 Victorian abortion law reform. Experts in abortion provision in Victoria were recruited for a qualitative semi-structured interview about the 2008 law reform and its perceived impact, until saturation was reached. Nineteen experts from a range of health care settings and geographic locations were interviewed in 2014/2015. Thematic analysis was conducted to summarise participants' views. Abortion law reform, while a positive event, was perceived to have changed little about the provision of abortion. The views of participants can be categorised into: (1) goals that law reform was intended to address and that have been achieved; (2) intent or hopes of law reform that have not been achieved; (3) unintended consequences; (4) coincidences; and (5) unfinished business. All agreed that law reform had repositioned abortion as a health rather than legal issue, had shifted the power in decision making from doctors to women, and had increased clarity and safety for doctors. However, all described outstanding concerns; limited public provision of surgical abortion; reduced access to abortion after 20 weeks; ongoing stigma; lack of a state-wide strategy for equitable abortion provision; and an unsustainable workforce. Law reform, while positive, has failed to address a number of significant issues in abortion service provision, and may have even resulted in a 'lull' in action. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

[Return to Work from Vocational RetrainingA Long-Term Analysis of Individual Trajectories: Biografical and Structural Conditions of Success and Failure].

PubMed

Meschnig, Alexander; von Kardorff, Ernst; Klaus, Sebastian

2018-03-28

The study aimed at the reconstruction of the trajectories of participants of a two-year vocational-retraining into new workplaces thereby identifying favourable and risky conditions of the return-to-work process. From a practical point of view the study identified special needs and necessities for after-care facilities. A Mixed-Method-Design was used. Quantitatively the follow-up-study included 214 persons who participated for three times on filling out a questionnaire over a period of eighteen months after the end of the vocational retraining. In the qualitative part of the study thirty persons consented to participate in a narrative-episodic interview on their vocational biography, their illness experiences at work and their way back into work. The study focused on the experiences of the participants from within, on their decision-making, coping, and rearrangement processes as well as on the experienced support from family members and rehabilitation professionals. About 75% of the participants of the vocational retraining succeeded in getting a job within the range of 18 months after finishing the retraining. Indicators for successful Return to Work are a high identification with the new vocation, effective coping with the remaining health problems, and an accepted arrangement with the disabilities in the work place and in everyday-life, a positive anticipation of the health condition in the future, and last but not least a satisfying social inclusion. As specific risk constellations for Return to Work emerged a lack of partnership, unfinished mental coping with the illness, negative subjective health prognosis, and a more passive attitude to life. © Georg Thieme Verlag KG Stuttgart · New York.

The rise of the boy-genius: psychological neoteny, science and modern life.

PubMed

Charlton, Bruce G

2006-01-01

The mid-20th century saw the rise of the boy-genius, probably because a personality type characterized by prolonged youthfulness is advantageous both in science and modern life generally. This is the evolution of 'psychological neoteny', in which ever-more people retain for ever-longer the characteristic behaviours and attitudes of earlier developmental stages. Whereas traditional societies are characterized by initiation ceremonies marking the advent of adulthood, these have now dwindled and disappeared. In a psychological sense, some contemporary individuals never actually become adults. A child-like flexibility of attitudes, behaviours and knowledge is probably adaptive in modern society because people need repeatedly to change jobs, learn new skills, move to new places and make new friends. It seems that this adaptation is achieved by the expedient of postponing cognitive maturation - a process that could be termed psychological neoteny. ('Neoteny' refers to the biological phenomenon whereby development is delayed such that juvenile characteristics are retained into maturity.) Psychological neoteny is probably caused by the prolonged average duration of formal education, since students' minds are in a significant sense 'unfinished'. Since modern cultures favour cognitive flexibility, 'immature' people tend to thrive and succeed, and have set the tone of contemporary life: the greatest praise of an elderly person is to state that they retain the characteristics of youth. But the faults of youth are retained with well as its virtues: short attention span, sensation- and novelty-seeking, short cycles of arbitrary fashion and a sense of cultural shallowness. Nonetheless, as health gets better and cosmetic technologies improve, future humans may become somewhat like an axolotl - the cave-dwelling salamander which retains its larval form until death.

[Prospective study of prevalence hearing loss in preterm neonates in an intensive care unit].

PubMed

Tomasik, Tomasz

2002-01-01

The risk of hearing loss is higher in prematurely born infants compared with neonates born at term. It is due to unfinished development of auditory path and exposition to many harmful factors related to treatment in a neonatal intensive care unit. Assessment of hearing loss risk factors in preterm babies. 152 newborns with mean birth weight 1408 +/- 551 g and gestational age 30.3 +/- 3.2 weeks. After discharge follow-up (Me = 32 months) study of newborns born before 37 weeks of gestation age. The patients were assigned into two groups: A) with hearing loss (n = 9) and B) without hearing loss (n = 143) according to the results of clinical observation and audiological assessment after 6 months of life. The rate of hearing loss was higher in new-borns born between 24-28 weeks of gestation (6/50, 12%) than in those born between 29-32 (2/52.3%) and 33-36 (1/43, 2%, p = 0.03). Identified risk factors independent of gestational age were: Gram negative sepsis (OR = 6; 95%CI: 1.32-27.33) and hyperbilirubinemia > 340 mumol/l (OR = 40.5; 95%CI: 73.27-503). The other risk factors are: shock (OR = 6.65; 95%CI: 1.44-30.64), hypercarbia (pCO2 > 80 mmHg) (OR = 5.13; 95%CI: 1.29-20.37), severe anemia (Ht < 24%) (OR = 6.0; 95%CI: 1.32-27.33). Prolonged treatment with aminoglicosides (over 10 days) also increased hearing loss risk (OR = 10.4; 95%CI: 1.27-85.75). The risk of hearing loss is highest in the newborn born between 24-28 weeks of gestation. It can be further increased by shock, hypercapnia, severe anemia, prolonged treatment with aminoglicosides. Gestational age independent factors are: hyperbilirubinemia and Gram negative sepsis.

Thin, Conductive Permafrost Surrounding Lake Fryxell Indicates Salts From Past Lakes, McMurdo Dry Valleys, Antarctica

NASA Astrophysics Data System (ADS)

Foley, N.; Tulaczyk, S. M.; Gooseff, M. N.; Myers, K. F.; Doran, P. T.; Auken, E.; Dugan, H. A.; Mikucki, J.; Virginia, R. A.

2017-12-01

In the McMurdo Dry Valleys (MDV), permafrost should be thick and liquid water rare. However, despite the well below zero mean annual temperature in this cryospheric desert, liquid water can be found in lakes, summer melt streams, subglacial outflow, and - recent work has shown - underneath anomalously thin permafrost. In part, this niche hydrosphere is maintained by the presence of salts, which depress the freezing point of water to perhaps as cold as -10° Celsius. We detected widespread salty water across the MDV in lakes and at depth using a helicopter-borne Time Domain Electromagnetic (TDEM) sensor. By using the presence of brines to mark the transition from frozen permafrost (near the surface) to unfrozen ground (at depth), we have created a map of permafrost thickness in Lower Taylor Valley (LTV), a large MDV with a complex history of glaciation and occupation by lakes. Our results show that permafrost is thinner ( 200m) than would be expected based on geothermal gradient measurements (up to 1000m), a result of the freezing point depression caused by salt and potentially enhanced by an unfinished transient freezing process. Near Lake Fryxell, a large, brackish lake in the center of LTV, permafrost is very thin (about 30-40m) and notably more electrically conductive than more distal permafrost. This thin ring of conductive permafrost surrounding the lake basin most likely reflects the high presence of salts in the subsurface, preventing complete freezing. These salts may be a remnant of the salty bottom waters of a historic larger lake (LGM glacially dammed Lake Washburn) or the remnant of salty basal water from a past advance of Taylor Glacier, which now sits many km up-valley but is known to contain brines which currently flow onto the surface and directly into the subsurface aquifer.

A doctor's duty is to heal the unhealthy: the story of Tun Dr Mahathir Mohamad.

PubMed

Ong, H T

2005-07-01

Mahathir Mohamad was born in 1925 in Alor Star, Kedah. He entered the King Edward VII College of Medicine in Singapore in 1947 and graduated in 1953. His years in the medical school equipped young Mahathir with the training necessary to assess and diagnose a problem, before dispensing the appropriate treatment. Throughout his later years in the political limelight, Dr Mahathir recognised the very important role the medical college had in laying the strong foundation for his successful career. He joined UMNO in 1945, already interested in politics at the tender age of 20; he was first elected into Parliament in 1964. The vigorous expression of his candid views did not go down well during the troubled days following the 13 May 1969 racial riots and he was expelled from UMNO, his writings were banned, and he was considered a racial extremist. Nevertheless, his intellectual and political influence could not be ignored for long; he returned to Parliament in 1974, and became the fourth, and longest serving, Prime Minister of Malaysia in 1981. Dr Mahathir has found fame as a Malay statesman, and an important Asian leader of the twentieth century with much written, locally and internationally, debating his policies. This article, using Dr Mahathir's own writings, starts with his description of his early life, proceeds to look at his medical career, then touches on his diagnosis of the problems plaguing the Malays, before concluding with his views on the need to stand up to the prejudices and pressures of the Western world. Throughout his life, Dr Mahathir behaved as the ever-diligent medical doctor, constantly studying the symptoms to diagnose the cause of the ills in his community and country, before proceeding to prescribe the correct treatment to restore good health. It is a measure of his integrity and intellectual capability that he did not seek to hide his failures, or cite unfinished work in an attempt to cling to political power.

[Bologna process and higher health education in Europe].

PubMed

Decsi, Tamás; Barakonyi, Károly

2006-08-27

Introduction of the two cycles (Bachelor/Master) system represents sensitive aspect of the implementation of the Bologna process into higher health education. The authors used the methods of evidence based medicine to analyse available documents on the implementation of the Bologna process into the education of health sciences. Electronic search in the closed MEDLINE and open Internet databases. Electronic data collection resulted in so-called country reports (n=47) and in professional statements (n=7) of health education bodies. Majority of the country reports (n=26) did not mention at all the peculiar position of health education within the Bologna process. Many country reports stated with (n=8) or without (n=9) explanation that health sciences should be excluded from the introduction of the two educational cycles system. Only 4 country reports discussed future conditions and possibilities of introducing the two cycles system into higher health education; the German country report definitely declared that the two cycles educational system may be introduced also into health education. The seven statements of professional health educational bodies (including an ad hoc committee of the Hungarian medical faculties) did not support the introduction of the two cycles system into health education. The low demand for health professionals with Bachelor (i.e. unfinished) degree was repeatedly mentioned as strong argument for not introducing the two cycles system into health education. It should be noted, however, that the process of introducing the two cycles system has began: recent survey of EUA (European University Association) indicates that in three countries (Denmark, Flanders and Switzerland) the introduction in under current discussion. Among the principles of the Bologna process, the introduction of the two cycles system has not gain acceptance in the higher health education in Europe. However, most documents firmly support the introduction of other elements of the Bologna process (comparable degrees, system of credits, promotion of mobility of students and tutors, quality control, life long learning).

Matefin/SUN-1 Phosphorylation Is Part of a Surveillance Mechanism to Coordinate Chromosome Synapsis and Recombination with Meiotic Progression and Chromosome Movement

PubMed Central

Woglar, Alexander; Daryabeigi, Anahita; Adamo, Adele; Habacher, Cornelia; Machacek, Thomas; La Volpe, Adriana; Jantsch, Verena

2013-01-01

Faithful chromosome segregation during meiosis I depends on the establishment of a crossover between homologous chromosomes. This requires induction of DNA double-strand breaks (DSBs), alignment of homologs, homolog association by synapsis, and repair of DSBs via homologous recombination. The success of these events requires coordination between chromosomal events and meiotic progression. The conserved SUN/KASH nuclear envelope bridge establishes transient linkages between chromosome ends and cytoskeletal forces during meiosis. In Caenorhabditis elegans, this bridge is essential for bringing homologs together and preventing nonhomologous synapsis. Chromosome movement takes place during synapsis and recombination. Concomitant with the onset of chromosome movement, SUN-1 clusters at chromosome ends associated with the nuclear envelope, and it is phosphorylated in a chk-2- and plk-2-dependent manner. Identification of all SUN-1 phosphomodifications at its nuclear N terminus allowed us to address their role in prophase I. Failures in recombination and synapsis led to persistent phosphorylations, which are required to elicit a delay in progression. Unfinished meiotic tasks elicited sustained recruitment of PLK-2 to chromosome ends in a SUN-1 phosphorylation–dependent manner that is required for continued chromosome movement and characteristic of a zygotene arrest. Furthermore, SUN-1 phosphorylation supported efficient synapsis. We propose that signals emanating from a failure to successfully finish meiotic tasks are integrated at the nuclear periphery to regulate chromosome end–led movement and meiotic progression. The single unsynapsed X chromosome in male meiosis is precluded from inducing a progression delay, and we found it was devoid of a population of phosphorylated SUN-1. This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover, inducible only in leptotene/zygotene. Unrepaired DSBs and unsynapsed chromosomes maintain this checkpoint, but a crossover intermediate is necessary to shut it down. PMID:23505384

Making Bengali Brick Lane: claiming and contesting space in East London.

PubMed

Alexander, Claire

2011-06-01

Based on a recent empirical project on 'the Bengal diaspora', the paper explores the construction and contestation of meanings around the iconic East London street, Brick Lane. Taking the 2006 protests around the film Brick Lane as its starting point, the paper draws on original interviews conducted in 2008 with a range of Bengali community representatives, to examine the narratives of space, community and belonging that emerge around the idea of Brick Lane as the 'cultural heartland' of the British Bangladeshi community. By exploring the representation, production and contestation of 'social space' through everyday practices, the paper engages with and contests the representation of minority ethnic 'communities' in the context of contemporary multicultural London and examines the process of 'claiming' and 'making' space in East London. In so doing, the paper contributes to a critical tradition that challenges essentialising and pathologizing accounts of ethnic communities and racialized spaces, or that places them outside of broader social and historical processes - redolent, for example, in contemporary discussions about 'parallel lives' or 'the clash of civilizations'. By contrast, this paper views social space as made through movement and narration, with a particular emphasis on the social agency of local Bengali inhabitants and the multiple meanings that emerge from within this 'imagined community'. However, rather than simply stressing the unfinished and processual nature of spatial meanings, the paper insists on the historical, embodied and affective dimensions of such meaning making, and a reckoning with the broader social and political landscape within which such meanings take shape. The focus on Brick Lane provides an empirically rich, geographically and historically located lens through which to explore the complex role of ethnicity as a marker of social space and of spatial practices of resistance and identity. By exploring Bengali Brick Lane through its narratives of past, present and future, these stories attest to the symbolic and emotional importance of such spaces, and to their complex imaginings. © London School of Economics and Political Science 2011.

PGP repository: a plant phenomics and genomics data publication infrastructure

PubMed Central

Arend, Daniel; Junker, Astrid; Scholz, Uwe; Schüler, Danuta; Wylie, Juliane; Lange, Matthias

2016-01-01

Plant genomics and phenomics represents the most promising tools for accelerating yield gains and overcoming emerging crop productivity bottlenecks. However, accessing this wealth of plant diversity requires the characterization of this material using state-of-the-art genomic, phenomic and molecular technologies and the release of subsequent research data via a long-term stable, open-access portal. Although several international consortia and public resource centres offer services for plant research data management, valuable digital assets remains unpublished and thus inaccessible to the scientific community. Recently, the Leibniz Institute of Plant Genetics and Crop Plant Research and the German Plant Phenotyping Network have jointly initiated the Plant Genomics and Phenomics Research Data Repository (PGP) as infrastructure to comprehensively publish plant research data. This covers in particular cross-domain datasets that are not being published in central repositories because of its volume or unsupported data scope, like image collections from plant phenotyping and microscopy, unfinished genomes, genotyping data, visualizations of morphological plant models, data from mass spectrometry as well as software and documents. The repository is hosted at Leibniz Institute of Plant Genetics and Crop Plant Research using e!DAL as software infrastructure and a Hierarchical Storage Management System as data archival backend. A novel developed data submission tool was made available for the consortium that features a high level of automation to lower the barriers of data publication. After an internal review process, data are published as citable digital object identifiers and a core set of technical metadata is registered at DataCite. The used e!DAL-embedded Web frontend generates for each dataset a landing page and supports an interactive exploration. PGP is registered as research data repository at BioSharing.org, re3data.org and OpenAIRE as valid EU Horizon 2020 open data archive. Above features, the programmatic interface and the support of standard metadata formats, enable PGP to fulfil the FAIR data principles—findable, accessible, interoperable, reusable. Database URL: http://edal.ipk-gatersleben.de/repos/pgp/ PMID:27087305

Child Care Provider Adherence to Infant and Toddler Feeding Recommendations: Findings from the Baby Nutrition and Physical Activity Self-Assessment for Child Care (Baby NAP SACC) Study

PubMed Central

Davison, Kirsten K.; Hesketh, Kathryn; Taveras, Elsie M.; Gillman, Matthew W.; Benjamin Neelon, Sara E.

2015-01-01

Abstract Background: Identifying characteristics associated with the Institute of Medicine's (IOM) recommended feeding practices among infant and toddler care providers in child care centers could help in preventing childhood obesity. Methods: In 2009, at baseline in a pilot intervention study of 29 licensed Massachusetts child care centers with at least 50% of enrolled children identified as racial minorities, 57 infant and 109 toddler providers completed feeding questionnaires. To assess provider adherence to six IOM-recommended behaviors, we used cluster-adjusted multivariable logistic regression models including provider type (infant or toddler), race, education, and center Child and Adult Care Food Program (CACFP) participation. Results: In multivariable analysis, CACFP participation was associated with providers sitting with children at meals (odds ratio [OR], 5.2; 95% confidence interval [CI], 1.2–21.7), offering fruits and vegetables (OR, 3.3; 95% CI 1.7–6.2), and limiting fast food (OR, 3.5; 95% CI, 1.8–6.7). Providers at centers serving meals family style were less likely to allow children to leave food unfinished (OR, 0.27; 95% CI, 0.09–0.77). Infant providers were more likely than toddler providers to sit with children at meals (OR, 6.98; 95% CI, 1.51–32.09), allow children to eat when hungry (OR, 3.50; 95% CI, 1.34–9.16), and avoid serving sugary (OR, 8.74; 95% CI, 3.05–25.06) or fast foods (OR, 11.56; 95% CI, 3.20–41.80). Conclusions: CACFP participation may encourage IOM-recommended feeding practices among infant and toddler providers. Child care providers may benefit from education about how to feed infants and toddlers responsively, especially when offering foods family style. Future research should explore ways to promote child-centered feeding practices, while addressing barriers to providing children with nutrient-rich foods. PMID:25918873

Use of DAGMan in CRAB3 to Improve the Splitting of CMS User Jobs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolf, M.; Mascheroni, M.; Woodard, A.

CRAB3 is a workload management tool used by CMS physicists to analyze data acquired by the Compact Muon Solenoid (CMS) detector at the CERN Large Hadron Collider (LHC). Research in high energy physics often requires the analysis of large collections of files, referred to as datasets. The task is divided into jobs that are distributed among a large collection of worker nodes throughout the Worldwide LHC Computing Grid (WLCG). Splitting a large analysis task into optimally sized jobs is critical to efficient use of distributed computing resources. Jobs that are too big will have excessive runtimes and will not distributemore » the work across all of the available nodes. However, splitting the project into a large number of very small jobs is also inefficient, as each job creates additional overhead which increases load on infrastructure resources. Currently this splitting is done manually, using parameters provided by the user. However the resources needed for each job are difficult to predict because of frequent variations in the performance of the user code and the content of the input dataset. As a result, dividing a task into jobs by hand is difficult and often suboptimal. In this work we present a new feature called “automatic splitting” which removes the need for users to manually specify job splitting parameters. We discuss how HTCondor DAGMan can be used to build dynamic Directed Acyclic Graphs (DAGs) to optimize the performance of large CMS analysis jobs on the Grid. We use DAGMan to dynamically generate interconnected DAGs that estimate the processing time the user code will require to analyze each event. This is used to calculate an estimate of the total processing time per job, and a set of analysis jobs are run using this estimate as a specified time limit. Some jobs may not finish within the alloted time; they are terminated at the time limit, and the unfinished data is regrouped into smaller jobs and resubmitted.« less

Balloon Angioplasty – The Legacy of Andreas Grüntzig, M.D. (1939–1985)

PubMed Central

Barton, Matthias; Grüntzig, Johannes; Husmann, Marc; Rösch, Josef

2014-01-01

In 1974, at the Medical Policlinic of the University of Zürich, German-born physician-scientist Andreas Grüntzig (1939–1985) for the first time applied a balloon-tipped catheter to re-open a severely stenosed femoral artery, a procedure, which he initially called “percutaneous transluminal dilatation”. Balloon angioplasty as a therapy of atherosclerotic vascular disease, for which Grüntzig and Charles T. Dotter (1920–1985) received a nomination for the Nobel Prize in Physiology or Medicine in 1978, became one of the most successful examples of translational medicine in the twentieth century. Known today as percutaneous transluminal angioplasty (PTA) in peripheral arteries or percutaneous transluminal coronary angioplasty (PTCA) or percutaneous coronary intervention (PCI) in coronary arteries, balloon angioplasty has become the method of choice to treat patients with acute myocardial infarction or occluded leg arteries. On the occasion of the 40th anniversary of balloon angioplasty, we summarize Grüntzig’s life and career in Germany, Switzerland, and the United States and also review the developments in vascular medicine from the 1890s to the 1980s, including Dotter’s first accidental angioplasty in 1963. The work of pioneers of catheterization, including Pedro L. Fariñas in Cuba, André F. Cournand in France, Werner Forssmann, Werner Porstmann and Eberhard Zeitler in Germany, António Egas Moniz and Reynaldo dos Santos in Portugal, Sven-Ivar Seldinger in Sweden, and Barney Brooks, Thomas J. Fogarty, Melvin P. Judkins, Richard K. Myler, Dickinson W. Richards, and F. Mason Sones in the United States, is discussed. We also present quotes by Grüntzig and excerpts from his unfinished autobiography, statements of Grüntzig’s former colleagues and contemporary witnesses, and have included hitherto unpublished historic photographs and links to archive recordings and historic materials. This year, on June 25, 2014, Andreas Grüntzig would have celebrated his 75th birthday. This article is dedicated to his memory. PMID:26664865

Outcomes of a peritoneal dialysis program in remote communities within Colombia.

PubMed

Sanabria, Mauricio; Devia, Martha; Hernández, Gilma; Astudillo, Kindar; Trillos, Carlos; Uribe, Mauricio; Latorre, Catalina; Bernal, Astrid; Rivera, Angela

2015-01-01

Colombia is a country of diverse geographic regions, some with mountainous terrain that can make access to urban areas difficult for individuals who live in remote areas. In 2005, a program was initiated to establish remote peritoneal dialysis (PD) centers in Colombia to improve access to PD for patients with end-stage renal disease who face geographic or financial access barriers. The present study was a multi-center cohort observational study of prevalent home PD patients who were at least 18 years of age and were being managed by one of nine established remote PD centers in Colombia over a 2-year period. Data were collected from clinical records, databases, and patient interviews. Patient survival, incidence of peritonitis, and rate of withdrawal from PD therapy were assessed. A total of 345 patients were eligible for the study. The majority (87.8%) of patients lived on one to two times a minimum monthly salary (equivalent to US$243 - US$486). On average, patients traveled 1.2 hours and 4.3 hours from their home to their remote PD center or an urban reference renal clinic, respectively. The incidence rate of peritonitis was 2.54 episodes per 100 patient-months of therapy. A bivariate analysis showed a significantly higher risk of peritonitis in patients who were living on less than one times a monthly minimum salary (p < 0.05) or who had a dirt, cement, or unfinished wood floor (p < 0.05). The 1-year and 2-year patient survival rates were 92.44% and 81.55%, respectively. The 1-year and 2-year technique survival rates were 97.27% and 89.78%, respectively. With the support of remote PD centers that mitigate geographic and financial barriers to healthcare, home PD therapy is a safe and appropriate treatment option for patients who live in remote areas in Colombia. Copyright © 2015 International Society for Peritoneal Dialysis.

Use of DAGMan in CRAB3 to improve the splitting of CMS user jobs

NASA Astrophysics Data System (ADS)

Wolf, M.; Mascheroni, M.; Woodard, A.; Belforte, S.; Bockelman, B.; Hernandez, J. M.; Vaandering, E.

2017-10-01

CRAB3 is a workload management tool used by CMS physicists to analyze data acquired by the Compact Muon Solenoid (CMS) detector at the CERN Large Hadron Collider (LHC). Research in high energy physics often requires the analysis of large collections of files, referred to as datasets. The task is divided into jobs that are distributed among a large collection of worker nodes throughout the Worldwide LHC Computing Grid (WLCG). Splitting a large analysis task into optimally sized jobs is critical to efficient use of distributed computing resources. Jobs that are too big will have excessive runtimes and will not distribute the work across all of the available nodes. However, splitting the project into a large number of very small jobs is also inefficient, as each job creates additional overhead which increases load on infrastructure resources. Currently this splitting is done manually, using parameters provided by the user. However the resources needed for each job are difficult to predict because of frequent variations in the performance of the user code and the content of the input dataset. As a result, dividing a task into jobs by hand is difficult and often suboptimal. In this work we present a new feature called “automatic splitting” which removes the need for users to manually specify job splitting parameters. We discuss how HTCondor DAGMan can be used to build dynamic Directed Acyclic Graphs (DAGs) to optimize the performance of large CMS analysis jobs on the Grid. We use DAGMan to dynamically generate interconnected DAGs that estimate the processing time the user code will require to analyze each event. This is used to calculate an estimate of the total processing time per job, and a set of analysis jobs are run using this estimate as a specified time limit. Some jobs may not finish within the alloted time; they are terminated at the time limit, and the unfinished data is regrouped into smaller jobs and resubmitted.

[Prevalence and risk factors for anemia in Southern Brazil].

PubMed

Neuman, N A; Tanaka, O Y; Szarfarc, S C; Guimarães, P R; Victora, C G

2000-02-01

To measure the prevalence and evaluate the risk factors of anemia. Cross sectional populational based study of the urban area of Criciuma town, in the state of Santa Catarina, Southern Brazil. The study population was a probabilistic sample of 476 children aged under three years. The prevalence of anemia found in the sample was 60.4% for children aged 0 to 35.9 months according to the Brault-Dubuc criteria and 54% for children aged 6 to 35.9 months according to the OMS criteria. The prevalence of anemia increases with age up to 18 months-old and then decreases. It is less prevalent in families where the father has a higher education level and where there is a higher total family income. Nevertheless, even within the 25% higher income group 40% of the children are anemic. The prevalence of anemia is higher among children living in unfinished and overcrowded houses, where the toilet is not equipped with flush, and among children who have two or more older brothers. It is also higher among teenager mothers (<20 years), and 35 years old or older mothers. The prevalence of anemia is lower among women who had 5 to 9 prenatal visits during pregnancy. Low weight at birth was associated with iron deficiency. The nutritional condition was associated with anemia only according to weight/age criteria. Hospitalizations in the last 12 months were not associated with the disease. In the hierarchical multivariate analysis children age, family income, and crowded house were the only significant variables. Reproductive health history, health service visits, birth weight, breast-feeding, anthropometry, and morbidity did not characterize a risk factor of anemia in the multivariate analysis. The study makes it evident that social inequality is a strong determinant of anemia. The risk imposed by anemia to children in regard to their health and intellectual development requires immediate action.

The double burden of disease among mining workers in Papua, Indonesia: at the crossroads between Old and New health paradigms.

PubMed

Rodriguez-Fernandez, Rodrigo; Ng, Nawi; Susilo, Dwidjo; Prawira, John; Bangs, Michael J; Amiya, Rachel M

2016-09-08

As the global shift toward non-communicable diseases overlaps with the unfinished agenda of confronting infectious diseases in low- and middle-income countries, epidemiological links across both burdens must be recognized. This study examined the non-communicable disease-infectious disease overlap in the specific comorbidity rates for key diseases in an occupational cohort in Papua, Indonesia. Diagnosed cases of ischaemic heart disease, stroke, hypertension, diabetes (types 1 and 2), chronic obstructive pulmonary disease, asthma, cancer, HIV and AIDS, tuberculosis, and malaria were extracted from 22,550 patient records (21,513 men, 1037 women) stored in identical electronic health information systems from two clinic sites in Papua, Indonesia. Data were collected as International Classification of Diseases, 10th Revision, entries from records spanning January-December 2013. A novel application of Circos software was used to visualize the interconnectedness between the disease burdens as overlapping prevalence estimates representing comorbidities. Overall, NCDs represented 38 % of all disease cases, primarily in the form of type 2 diabetes (n = 1440) and hypertension (n = 1398). Malaria cases represented the largest single portion of the disease burden with 5310 recorded cases, followed by type 2 diabetes with 1400 cases. Tuberculosis occurred most frequently alongside malaria (29 %), followed by chronic obstructive pulmonary disease (19 %), asthma (17 %), and stroke (12 %). Hypertension-tuberculosis (4 %), tuberculosis-cancer (4 %), and asthma-tuberculosis (2 %) comorbidities were also observed. The high prevalence of multimorbidity, preponderance of non-communicable diseases, and extensive interweaving of non-communicable and infectious disease comorbidities highlighted in this cohort of mining workers in Papua, Indonesia reflect the markedly double disease burden increasingly plaguing Indonesia and other similar low- and middle-income countries - a challenge with which their over-stretched, under-resourced health systems are ill-equipped to cope. Integrated, person-centered treatment and control strategies rooted in the primary healthcare sector will be critical to reverse this trend.

A novel photo-grafting of acrylamide onto carboxymethyl starch. 1. Utilization of CMS-g-PAAm in easy care finishing of cotton fabrics.

PubMed

El-Sheikh, Manal A

2016-11-05

The photosensitized grafting of vinyl monomers onto a range of polymeric substrates has been the subject of particular interest in the recent past. Carboxymethyl starch (CMS)-poly acrylamide (PAAm) graft copolymer (CMS-g-PAAm) with high graft yield was successfully prepared by grafting of acrylamide onto CMS using UV irradiation in the presence of the water soluble 4-(trimethyl ammoniummethyl) benzophenone chloride photoinitiator. CMS-g-PAAm with nitrogen content of 8.3% and grafting efficiency up to 98.9% was obtained using 100% AAm, a material: liquor ratio of 1:14 and 1% photinitiator at 30°C for 1h of UV irradiation. The synthesis of CMS-g-PAAm was confirmed by FTIR and Nitrogen content (%). Surface morphology of CMS and surface morphological changes of CMS after grafting with AAm were studied using SEM. Thermal properties of both CMS and CMS-g-PAAm were studied using TGA and DSC. To impart easy care finishing to cotton fabrics, aqueous formulations of: CMS-g-PAAm, dimethylol dihydroxy ethylene urea (DMDHEU), CMS-g-PAAm-DMDHEU mixture or methylolated CMS-g-PAAm were used. Cotton fabrics were padded in these formulations, squeezed to a wet pick up 100%, dried at 100°C for 5min, cured at 150°C for 5min, washed at 50°C for 10min and air-dried. CRA (crease recovery angle) of untreated fabrics and fabrics finished with a mixture of 2% CMS-g-PAAm and 10% DMDHEU or methylolated CMS-g-PAAm (10% formaldehyde) were: 136°, 190°, 288° respectively. Increasing the number of washing cycles up to five cycles results in an insignificant decrease in the CRA and a significant decrease in RF (releasable formaldehyde) of finished fabric samples. The morphologies of the finished and unfinished cotton fabrics were performed by SEM. Copyright © 2016 Elsevier Ltd. All rights reserved.

Outcomes of a Peritoneal Dialysis Program in Remote Communities Within Colombia

PubMed Central

Sanabria, Mauricio; Devia, Martha; Hernández, Gilma; Astudillo, Kindar; Trillos, Carlos; Uribe, Mauricio; Latorre, Catalina; Bernal, Astrid; Rivera, Angela

2015-01-01

♦ Background and Objective: Colombia is a country of diverse geographic regions, some with mountainous terrain that can make access to urban areas difficult for individuals who live in remote areas. In 2005, a program was initiated to establish remote peritoneal dialysis (PD) centers in Colombia to improve access to PD for patients with end-stage renal disease who face geographic or financial access barriers. ♦ Patients and Methods: The present study was a multi-center cohort observational study of prevalent home PD patients who were at least 18 years of age and were being managed by one of nine established remote PD centers in Colombia over a 2-year period. Data were collected from clinical records, databases, and patient interviews. Patient survival, incidence of peritonitis, and rate of withdrawal from PD therapy were assessed. ♦ Results: A total of 345 patients were eligible for the study. The majority (87.8%) of patients lived on one to two times a minimum monthly salary (equivalent to US$243 – US$486). On average, patients traveled 1.2 hours and 4.3 hours from their home to their remote PD center or an urban reference renal clinic, respectively. The incidence rate of peritonitis was 2.54 episodes per 100 patient-months of therapy. A bivariate analysis showed a significantly higher risk of peritonitis in patients who were living on less than one times a monthly minimum salary (p < 0.05) or who had a dirt, cement, or unfinished wood floor (p < 0.05). The 1-year and 2-year patient survival rates were 92.44% and 81.55%, respectively. The 1-year and 2-year technique survival rates were 97.27% and 89.78%, respectively. ♦ Conclusions: With the support of remote PD centers that mitigate geographic and financial barriers to healthcare, home PD therapy is a safe and appropriate treatment option for patients who live in remote areas in Colombia. PMID:24497583

The impact of China's national essential medicine system on improving rational drug use in primary health care facilities: an empirical study in four provinces.

PubMed

Song, Yan; Bian, Ying; Petzold, Max; Li, Lingui; Yin, Aitian

2014-10-25

The National Essential Medicine System (NEMS) is a new policy in China launched in 2009 to improve the appropriate use of medications. This study aims to examine the outcomes of the NEMS objectives in terms of the rational use of medicines in primary health care facilities in China. A total of 28,651 prescriptions were collected from 146 township health centers in four provinces of China by means of a field survey conducted in 2010-2011. Indicators of rational drug use were extracted and compared using a pre/post design and then evaluated with regard to the World Health Organization (WHO) Standard Guidelines and data from previous research. The average number of drugs per prescription decreased from 3.64 to 3.46 (p < 0.01) between 2009 and 2010. Little effect was found for the NEMS on the average number of antibiotics per prescription, but the percentage of prescriptions including antibiotics decreased from 60.26 to 58.48% (p < 0.01). Prescriptions for injections or adrenal corticosteroids also decreased, to 40.31 and 11.16% of all prescriptions, respectively. All these positive issues were also recorded in 2011. However, each of the above values remained higher than WHO standards. The percentage of drugs prescribed from the Essential Drug List increased after the implementation of the NEMS (p < 0.01). Where the available data allowed changes in costs to be assessed, the average expense per prescription increased significantly, from 25.77 to 27.09 yuan (p < 0.01). The NEMS effectively improved rational medicine use in China. However, polypharmacy and the over-prescription of antibiotics and injections remain common. There is still a large unfinished agenda requiring policy improvements. Treatment guidelines, intensive support supervision, and continuing training for both professionals and consumers are the essential actions that need to be taken.

Haloprofundus marisrubri gen. nov., sp. nov., an extremely halophilic archaeon isolated from a brine-seawater interface.

PubMed

Zhang, Guishan; Gu, Jingang; Zhang, Ruifu; Rashid, Mamoon; Haroon, Mohamed Fauzi; Xun, Weibing; Ruan, Zhiyong; Dong, Xiuzhu; Stingl, Ulrich

2017-01-01

We isolated a Gram-stain-negative, pink-pigmented, motile, pleomorphic, extremely halophilic archaeon from the brine-seawater interface of Discovery Deep in the Saudi Arabian Red Sea. This strain, designated SB9T, was capable of growth within a wide range of temperatures and salinity, but required MgCl2. Cells lysed in distilled water, but at 7.0 % (w/v) NaCl cell lysis was prevented. The major polar lipids from strain SB9T were phosphatidylglycerol, phosphatidylglycerolphosphate methyl ester, sulfated mannosyl glucosyl diether, mannosyl glucosyl diether, an unidentified glycolipid and two unidentified phospholipids. The major respiratory quinones of strain SB9T were menaquinones MK8 (66 %) and MK8 (VIII-H2) (34 %). Analysis of the 16S rRNA gene sequence revealed that strain SB9T was closely related to species in the genera Halogranum and Haloplanus; in particular, it shared highest sequence similarity with the type strain of Halogranum rubrum (93.4 %), making it its closest known relative. The unfinished draft genome of strain SB9Twas 3 931 127 bp in size with a total G+C content of 62.53 mol% and contained 3917 ORFs, 50 tRNAs and eight rRNAs. Based on comparisons with currently available genomes, the highest average nucleotide identity value was 83 % to Halogranum salarium B-1T (GenBank accession no. GCA_000283335.1). These data indicate that this new isolate cannot be classified into any recognized genera of the family Haloferacaceae, and therefore strain SB9T is considered to be a representative of a novel species of a new genus within this family, for which the name Haloprofundus marisrubri gen. nov., sp. nov. is proposed. The type strain of Haloprofundus marisrubri is SB9T (=JCM 19565T=CGMCC 1.14959T).

Plastic Deformation of Quartz: Unfinished business?

NASA Astrophysics Data System (ADS)

Paterson, M. S.

2011-12-01

Starting at Harvard in the mid-1930's, David Griggs built a series of high pressure machines for experimental rock deformation. One persistent aim was to achieve the plastic deformation of quartz. Each time he built a new machine for higher pressure and/or temperature, one of the first materials he tested would be quartz. This search went on through a 500 MPa liquid-medium machine at temperatures up to 300°C, then with a gas-medium machine for temperatures up to 800°C, and finally with a solid-medium machine for higher pressures and temperatures. Quartz proved stubbornly resistant to deformation except at extremely high stresses until, finally and somewhat serendipitously, it was found possible to deform quartz at relatively low stresses in the presence of water under special conditions. The breakthrough came in an experiment in a 1500 MPa solid-medium apparatus in which talc was used as pressure medium. At the temperature of the experiment, the talc dehydrated and so released water. Under these conditions, natural quartz proved to be very weak and to readily undergo plastic deformation, a phenomenon that became known as "hydrolytic weakening". Soon after this discovery, it was also found that certain synthetic single crystals could be easily deformed ab initio. These crystals were from a particular set that had been grown rapidly under hydrothermal conditions and had incorporated water during growth. Attempts in our laboratory to weaken crystals in a gas-medium apparatus at around 300 MPa by cooking dry quartz in the presence of added water were all unsuccessful, although we could deform wet synthetic crystals. There was considerable speculation about a role of high pressure in promoting hydrolytic weakening, but the dilemma was eventually clarified by electron microscope studies by Fitz Gerald and coworkers. These studies showed that crystals that had been subjected to high pressure and temperature in the solid-medium apparatus were extensively microcracked, presumably due to non-hydrostatic stresses generated from the solid medium during raising the pressure, thus evidently promoting the ingress of water. From our gas-medium experiments it would seem that both the solubility and the rate of diffusion of water-related species in dry quartz must be very low, such that at 300 MPa and around 500 - 1000 °C the water penetrates less than a few micrometres in the course of a few hours. Thus the sluggishness of diffusion and the low equilibrium solubility of water-related species in quartz probably explain the failure to achieve hydrolytic weakening in the gas-medium apparatus. However, the documentation of these properties remains inadequate. The initial, and still current, Frank-Griggs hypothesis for the origin of hydrolytic weakening is that the water plays a role in the breaking of the covalent silicon-oxygen bonds as a dislocation is propagated. It is a corollary that the dislocation must be saturated with water or that the water must migrate with the dislocation as it moves. Heggie and Jones have done a number of ab initio calculations on the role of the water in the migration of dislocations in quartz which support the idea that the motion of dislocations is aided by the presence of water-related species in the dislocation core.

PGP repository: a plant phenomics and genomics data publication infrastructure.

PubMed

Arend, Daniel; Junker, Astrid; Scholz, Uwe; Schüler, Danuta; Wylie, Juliane; Lange, Matthias

2016-01-01

Plant genomics and phenomics represents the most promising tools for accelerating yield gains and overcoming emerging crop productivity bottlenecks. However, accessing this wealth of plant diversity requires the characterization of this material using state-of-the-art genomic, phenomic and molecular technologies and the release of subsequent research data via a long-term stable, open-access portal. Although several international consortia and public resource centres offer services for plant research data management, valuable digital assets remains unpublished and thus inaccessible to the scientific community. Recently, the Leibniz Institute of Plant Genetics and Crop Plant Research and the German Plant Phenotyping Network have jointly initiated the Plant Genomics and Phenomics Research Data Repository (PGP) as infrastructure to comprehensively publish plant research data. This covers in particular cross-domain datasets that are not being published in central repositories because of its volume or unsupported data scope, like image collections from plant phenotyping and microscopy, unfinished genomes, genotyping data, visualizations of morphological plant models, data from mass spectrometry as well as software and documents.The repository is hosted at Leibniz Institute of Plant Genetics and Crop Plant Research using e!DAL as software infrastructure and a Hierarchical Storage Management System as data archival backend. A novel developed data submission tool was made available for the consortium that features a high level of automation to lower the barriers of data publication. After an internal review process, data are published as citable digital object identifiers and a core set of technical metadata is registered at DataCite. The used e!DAL-embedded Web frontend generates for each dataset a landing page and supports an interactive exploration. PGP is registered as research data repository at BioSharing.org, re3data.org and OpenAIRE as valid EU Horizon 2020 open data archive. Above features, the programmatic interface and the support of standard metadata formats, enable PGP to fulfil the FAIR data principles-findable, accessible, interoperable, reusable.Database URL:http://edal.ipk-gatersleben.de/repos/pgp/. © The Author(s) 2016. Published by Oxford University Press.

'Infantile convulsions' in the early nineteenth century. Abnormal brain blood flow and leeches, teething and gums' scarification and food and purgatives: the historical contribution of John Clarke (1760-1815).

PubMed

Brigo, Francesco; Lattanzi, Simona; Trinka, Eugen; Nardone, Raffaele; Bragazzi, Nicola Luigi; Ruggieri, Martino; Vecchio, Ignazio; Martini, Mariano

2018-07-01

In this article, we discuss on the role of the British physician and midwifery practitioner John Clarke (1760-1815) in the characterisation of the various types of seizures and epilepsy and related phenomena ('convulsions') occurring in children. In his unfinished work Commentaries on Some of the Most Important Diseases of Children (1815), Clarke discussed the pathophysiology of convulsions and was the first to describe, 12 years before the French neurologist Louis Francois Bravais (1801-1843) and more than 30 years before the Irish-born physician Robert Bentley Todd (1809-1860), the postictal paresis. He believed that convulsions originated from changes in pressure within the ventricles as a consequence of abnormal blood flow to the cerebral vessels. In keeping with the theories of his time (e.g. Baumes 1789, 1805; Brachet 1824), Clarke believed that teething was a major cause of 'infantile convulsions'. His proposed remedies ranged from scarification of the gums to ammonia, application of leeches, cold water, and purgatives. The use of antispasmodics, quite popular at the time, was instead questioned. In his Practical Observations on the Convulsions of Infants (1826), the London practitioner and midwifery John North (1790-1873) deeply criticised Clarke's view that convulsions arise inevitably as a consequence of organic brain lesions. North inferred that the results of autopsies of children who had died of convulsions revealed no brain damages, and claimed that cerebral irritation could also occur as the effect of distant lesions. Other Clarke's contemporaries (e.g. Jean Baptiste Timothée Baumes-1756-1828) inferred that all convulsions reflected a hereditary diathesis, which rendered children (especially those with softer and limper nervous and muscular tissues!) extremely sensitive to all sorts of provocation that could trigger convulsions, including bad digestion (more pronounced at the time of teething), loud noise, and bright light. Although almost every aspect of Clarke's view on convulsions was subsequently proved wrong, his (and his contemporaries') work provides fascinating insights into the theories and therapies of seizures, which were popular at the dawn of modern neurology.

Beijing diary: ten days at the women's conference.

PubMed

Craft, N

1995-10-14

A British Medical Journal editor recorded her impressions and experiences at the Fourth World Conference on Women in the form of a 10-day diary. She described a logistical nightmare extending from her attempt to check into the hotel where she had a reservation to workshops and meetings held in unfinished buildings, overcrowded classrooms, and public areas of a hotel (even after hotel management extinguished the lights). The journalist's movements were dutifully recorded by a uniformed attendant, and taxi drivers refused to take her to the conference center. Early lobbying and strategy meetings revolved around the issues to be discussed at the conference. The opening of the Conference was marked with pomp and ceremony while workshops held at the nongovernmental (NGO) forum 50 miles away provided an opportunity for women to describe their attempts to improve their status. Rain forced Hilary Clinton to speak inside and disappointed thousands of women who had waited in line for hours to hear her comments. Betty Friedan described the conference as a metaphor for women's experience in the world and called for a "new vision of equality." Debates at the NGO forum centered around the rights of parents to have access to their children's medical records and punitive measures for women who have had abortions. At the Conference, the UN was unable to explain the paucity of women in positions of under secretary general or higher. By the end of the first week, the governments of Australia, India, Tanzania, China, the US, Ghana, the UK, Turkey, and Cambodia had all made commitments to improve the status of women. During the second week of the Conference the wording for the Beijing Declaration and Platform for Action was passed through various committees. The resulting document represents a significant contribution to the gradual progress towards equity for women, instead of a major shift in world view, but grassroots organizations will find in it the ammunition to hold governments to promises made in Beijing. The logistical problems of the Conference provide a manifestation of the roadblocks that women will face as they attempt to change their role in society. They also illustrate the problems encountered by anyone attempting to challenge the status quo in China.

Socio-cultural and behavioural factors constraining latrine adoption in rural coastal Odisha: an exploratory qualitative study.

PubMed

Routray, Parimita; Schmidt, Wolf-Peter; Boisson, Sophie; Clasen, Thomas; Jenkins, Marion W

2015-09-10

Open defecation is widely practiced in India. To improve sanitation and promote better health, the Government of India (GOI) has instituted large scale sanitation programmes supporting construction of public and institutional toilets and extending financial subsidies for poor families in rural areas for building individual household latrines. Nevertheless, many household latrines in rural India, built with government subsidies and the facilitation and support of non-government organizations (NGO), remain unused. Literature on social, cultural and behavioural aspects that constrain latrine adoption and use in rural India is limited. This paper examines defecation patterns of different groups of people in rural areas of Odisha state in India to identify causes and determinants of latrine non-use, with a special focus on government-subsidized latrine owners, and shortcomings in household sanitation infrastructure built with government subsidies. An exploratory study using qualitative methods was conducted in rural communities in Odisha state. Methods used were focus group discussions (FGDs), and observations of latrines and interviews with their owners. FGDs were held with frontline NGO sanitation program staff, and with community members, separately by caste, gender, latrine type, and age group. Data were analysed using a thematic framework and approach. Government subsidized latrines were mostly found unfinished. Many counted as complete per government standards for disbursement of financial subsidies to contracted NGOs were not accepted by their owners and termed as 'incomplete'. These latrines lacked a roof, door, adequate walls and any provision for water supply in or near the cabin, whereas rural people had elaborate processes of cleansing with water post defecation, making presence of a nearby water source important. Habits, socialising, sanitation rituals and daily routines varying with caste, gender, marital status, age and lifestyle, also hindered the adoption of latrines. Interest in constructing latrines was observed among male heads for their female members especially a newlywed daughter-in-law, reflecting concerns for their privacy, security, and convenience. This paper elaborates on these different factors. Findings show that providing infrastructure does not ensure use when there are significant and culturally engrained behavioural barriers to using latrines. Future sanitation programmes in rural India need to focus on understanding and addressing these behavioural barriers.

Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors

PubMed Central

2013-01-01

Background The widespread protozoan parasite Toxoplasma gondii interferes with host cell functions by exporting the contents of a unique apical organelle, the rhoptry. Among the mix of secreted proteins are an expanded, lineage-specific family of protein kinases termed rhoptry kinases (ROPKs), several of which have been shown to be key virulence factors, including the pseudokinase ROP5. The extent and details of the diversification of this protein family are poorly understood. Results In this study, we comprehensively catalogued the ROPK family in the genomes of Toxoplasma gondii, Neospora caninum and Eimeria tenella, as well as portions of the unfinished genome of Sarcocystis neurona, and classified the identified genes into 42 distinct subfamilies. We systematically compared the rhoptry kinase protein sequences and structures to each other and to the broader superfamily of eukaryotic protein kinases to study the patterns of diversification and neofunctionalization in the ROPK family and its subfamilies. We identified three ROPK sub-clades of particular interest: those bearing a structurally conserved N-terminal extension to the kinase domain (NTE), an E. tenella-specific expansion, and a basal cluster including ROP35 and BPK1 that we term ROPKL. Structural analysis in light of the solved structures ROP2, ROP5, ROP8 and in comparison to typical eukaryotic protein kinases revealed ROPK-specific conservation patterns in two key regions of the kinase domain, surrounding a ROPK-conserved insert in the kinase hinge region and a disulfide bridge in the kinase substrate-binding lobe. We also examined conservation patterns specific to the NTE-bearing clade. We discuss the possible functional consequences of each. Conclusions Our work sheds light on several important but previously unrecognized features shared among rhoptry kinases, as well as the essential differences between active and degenerate protein kinases. We identify the most distinctive ROPK-specific features conserved across both active kinases and pseudokinases, and discuss these in terms of sequence motifs, evolutionary context, structural impact and potential functional relevance. By characterizing the proteins that enable these parasites to invade the host cell and co-opt its signaling mechanisms, we provide guidance on potential therapeutic targets for the diseases caused by coccidian parasites. PMID:23742205

Matters of Scale: Sociology in and for a Complex World.

PubMed

Pyyhtinen, Olli

2017-08-01

The article proposes that if sociology is to make sense of a world that is ever more complex and complicated, it is important to reconsider the scale(s) of our relations and actions. Instead of assuming a nested vertical hierarchy of the micro to macro binary, scale should be treated not only as multiple, but also as something produced and sustained in practice. Coming to grips with the complex world, we are living in also necessitates attending to the conduits and connections between various sites, fields, and terrains to which our lives are entangled. The article concludes with a note on the marginalization of sociology from public discussions, and it argues that it is possibly by attending to ambiguity and to the unfinished making of our contemporary world that sociology might have the most to give to discussions about the economy, about the future of humanity, and how to organize society. Cet article suggère que si la sociologie doit nous éclairer sur le sens d'un monde de plus en plus complexe, il est important de revoir l'échelle de nos relations et actions. Au lieu d'assumer une hiérarchie verticale de la dualité micro-macro, cette étendue doit être traitée non seulement comme multiple, mais aussi comme une chose produite et soutenue par la pratique. Pour faire face à la complexité du monde dans lequel nous vivons, il faut aussi de s'occuper des conduits et connections entre des sites divers, des champs, et des terrains dans lesquels nos vies se déroulent. Cet article conclut avec une note sur la marginalisation de la sociologie dans les discussions publiques ; et il défend l'idée que c'est possiblement en appréhendant l'ambiguïté et la construction incomplète de notre monde contemporain que la sociologie peut être la plus fructueuse en termes de discussions portant sur l'économie, le futur de l'humanité, et l'organisation de la société. © 2017 Canadian Sociological Association/La Société canadienne de sociologie.

Statins research unfinished saga: desirability versus feasibility.

PubMed

Fisman, Enrique Z; Adler, Yehuda; Tenenbaum, Alexander

2005-06-07

Drugs in the same class are generally thought to be therapeutically equivalent because of similar mechanisms of action (the so-called "class effect"). However, statins differ in multiple characteristics, including liver and renal metabolism, half-life, effects on several serum lipid components, bioavailability and potency. Some are fungal derivatives, and others are synthetic compounds. The percentage absorption of an oral dose, amount of protein binding, degree of renal excretion, hydrophilicity, and potency on a weight basis is variable. These differences may be even greater in diabetic patients, who may present diabetes-induced abnormalities in P450 isoforms and altered hepatic metabolic pathways. Thus, it is obvious that head-to-head comparisons between different statins are preferable than trial-to-trial comparisons. Such assessments are of utmost importance, especially in cases in which specific populations with a distinct lipid profile and altered metabolic pathways, like diabetics, are studied. It should be specially pinpointed that patients with metabolic syndrome and diabetes constitute also a special population regarding their atherogenic dyslipidemia, which is usually associated with low HDL-cholesterol, hypertriglyceridemia and predominance of small dense LDL-cholesterol. Therefore, these patients may benefit from fibrates or combined statin/fibrate treatment. This policy is not accomplished since in the real world things are more complex. Trials would require very large sample sizes and long-term follow-up to detect significant differences in myocardial infarction or death between two different statins. Moreover, the fact that new compounds are under several phases of research and development represents an additional drawback for performing the trials. Ideally, head-to-head trials regarding clinically important outcomes should be conducted for all drugs. Nonetheless, the desirability of performing such trials, which epitomize modern evidence-based medicine, is frequently superseded by the feasibility dictated by pragmatic and economic circumstances. In the latter case, in absence of solid systematic documentation of comparable health benefits and long-term safety, both researchers and practicing physicians should allude to the weight of scientific endorsement behind the arguments and seek for the possible strengths and weaknesses intrinsic to each specific study. In any case, conclusions based on surrogate endpoints cannot completely substitute head-to-head comparisons regarding patients' outcome.

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons

PubMed Central

2011-01-01

Background Visualisation of genome comparisons is invaluable for helping to determine genotypic differences between closely related prokaryotes. New visualisation and abstraction methods are required in order to improve the validation, interpretation and communication of genome sequence information; especially with the increasing amount of data arising from next-generation sequencing projects. Visualising a prokaryote genome as a circular image has become a powerful means of displaying informative comparisons of one genome to a number of others. Several programs, imaging libraries and internet resources already exist for this purpose, however, most are either limited in the number of comparisons they can show, are unable to adequately utilise draft genome sequence data, or require a knowledge of command-line scripting for implementation. Currently, there is no freely available desktop application that enables users to rapidly visualise comparisons between hundreds of draft or complete genomes in a single image. Results BLAST Ring Image Generator (BRIG) can generate images that show multiple prokaryote genome comparisons, without an arbitrary limit on the number of genomes compared. The output image shows similarity between a central reference sequence and other sequences as a set of concentric rings, where BLAST matches are coloured on a sliding scale indicating a defined percentage identity. Images can also include draft genome assembly information to show read coverage, assembly breakpoints and collapsed repeats. In addition, BRIG supports the mapping of unassembled sequencing reads against one or more central reference sequences. Many types of custom data and annotations can be shown using BRIG, making it a versatile approach for visualising a range of genomic comparison data. BRIG is readily accessible to any user, as it assumes no specialist computational knowledge and will perform all required file parsing and BLAST comparisons automatically. Conclusions There is a clear need for a user-friendly program that can produce genome comparisons for a large number of prokaryote genomes with an emphasis on rapidly utilising unfinished or unassembled genome data. Here we present BRIG, a cross-platform application that enables the interactive generation of comparative genomic images via a simple graphical-user interface. BRIG is freely available for all operating systems at http://sourceforge.net/projects/brig/. PMID:21824423

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons.

PubMed

Alikhan, Nabil-Fareed; Petty, Nicola K; Ben Zakour, Nouri L; Beatson, Scott A

2011-08-08

Visualisation of genome comparisons is invaluable for helping to determine genotypic differences between closely related prokaryotes. New visualisation and abstraction methods are required in order to improve the validation, interpretation and communication of genome sequence information; especially with the increasing amount of data arising from next-generation sequencing projects. Visualising a prokaryote genome as a circular image has become a powerful means of displaying informative comparisons of one genome to a number of others. Several programs, imaging libraries and internet resources already exist for this purpose, however, most are either limited in the number of comparisons they can show, are unable to adequately utilise draft genome sequence data, or require a knowledge of command-line scripting for implementation. Currently, there is no freely available desktop application that enables users to rapidly visualise comparisons between hundreds of draft or complete genomes in a single image. BLAST Ring Image Generator (BRIG) can generate images that show multiple prokaryote genome comparisons, without an arbitrary limit on the number of genomes compared. The output image shows similarity between a central reference sequence and other sequences as a set of concentric rings, where BLAST matches are coloured on a sliding scale indicating a defined percentage identity. Images can also include draft genome assembly information to show read coverage, assembly breakpoints and collapsed repeats. In addition, BRIG supports the mapping of unassembled sequencing reads against one or more central reference sequences. Many types of custom data and annotations can be shown using BRIG, making it a versatile approach for visualising a range of genomic comparison data. BRIG is readily accessible to any user, as it assumes no specialist computational knowledge and will perform all required file parsing and BLAST comparisons automatically. There is a clear need for a user-friendly program that can produce genome comparisons for a large number of prokaryote genomes with an emphasis on rapidly utilising unfinished or unassembled genome data. Here we present BRIG, a cross-platform application that enables the interactive generation of comparative genomic images via a simple graphical-user interface. BRIG is freely available for all operating systems at http://sourceforge.net/projects/brig/.

Interruptions in a level one trauma center: a case study.

PubMed

Brixey, Juliana J; Tang, Zhihua; Robinson, David J; Johnson, Craig W; Johnson, Todd R; Turley, James P; Patel, Vimla L; Zhang, Jiajie

2008-04-01

The emergency department has been characterized as interrupt-driven. Government agencies and patient safety organizations recognize that interruptions contribute to medical errors. The purpose of this study was to observe, record, and contextualize activities and interruptions experienced by physicians and Registered Nurses (RNs) working in a Level One Trauma Center. A case study that relied on an ethnographic study design using the shadowing method. A convenience sample of physicians and RNs, each with at least 6 months of experience in the Emergency Department (ED), were asked to participate. In these kinds of detailed qualitative investigations, it is quite common to have a small sample size. Ethical approval: Approval was obtained from institutional ethic committees prior to initiating the study. Community consent was obtained from the ED staff through in-service education. All observations were made in the trauma section of the ED of a tertiary teaching hospital. The hospital is situated in a major medical center in the Gulf Coast region of the United States of America (USA). Five attending ED physicians were observed for a total of 29h, 31min. Eight RNs were shadowed for a total of 40 h, 9min. Interruptions and activities were categorized using the Hybrid Method to Categorize Interruptions and Activities (HyMCIA). Registered Nurses received slightly more interruptions per hour than physicians. People, pagers, and telephones were identified as mediums through which interruptions were delivered. The physical environment was found to contribute to interruptions in workflow because of physical design and when supplies were not available. Physicians and RNs usually returned to the original, interrupted activity more often than leaving the activity unfinished. This research provides an enhanced understanding of interruptions in workflow in the ED, the identification of work constraints, and the need to develop interventions to manage interruptions. It is crucial that interruptions be delivered in such a way that there is minimal negative impact on performance. The significance and importance of the interruption must always be weighed against the negative impact that it has on smooth, efficient workflow.

The Relation between Teachers’ and Children’s Playfulness: A Pilot Study

PubMed Central

Pinchover, Shulamit

2017-01-01

Young children spend considerable time in educational settings, in which traditionally, their primary occupation is play. A playful preschool environment has been related to better cognitive, social and emotional development. Although it is assumed that teachers’ playful behaviors are important in creating a playful school environment, empirical knowledge on this subject is lacking. The current study pilot examines the relation between teachers’ and children’s playfulness. Thirty-one teacher–child dyads participated. The teachers were asked to complete the Adult Playfulness Scale (APS). Thirty-minute videotapes of teacher–child play interactions were used to evaluate the child’s playfulness using the Test of Playfulness. A positive relation was found between two of the APS subscales (spontaneity and silliness) and child playfulness. Teacher silliness mediated the relation between children’s age and playfulness. This study is the first to show that teachers’ playfulness aspects are related to higher playfulness in children. Promoting teachers’ playful behaviors can be related to better teacher–child playful interactions, thereby enhancing children’s playfulness. PMID:29312069

Playing it cool: Characterizing social play, bout termination, and candidate play signals of juvenile and infant Tibetan macaques (Macaca thibetana).

PubMed

Wright, Kaitlin R; Mayhew, Jessica A; Sheeran, Lori K; Funkhouser, Jake A; Wagner, Ronald S; Sun, Li-Xing; Li, Jin-Hua

2018-07-18

Play behaviors and signals during playful interactions with juvenile conspecifics are important for both the social and cognitive development of young animals. The social organization of a species can also influence juvenile social play. We examined the relationships among play behaviors, candidate play signals, and play bout termination in Tibetan macaques (Macaca thibetana) during juvenile and infant social play to characterize the species play style. As Tibetan macaques are despotic and live in groups with strict linear dominance hierarchies and infrequent reconciliation, we predicted that play would be at risk of misinterpretation by both the individuals engaged in the play bout and by those watching, possibly leading to injury of the players. Animals living in such societies might need to frequently and clearly signal playful intent to play partners and other group members to avoid aggressive outcomes. We gathered video data on 21 individually-identified juvenile and infant macaques (one month to five years of age) from the Valley of the Wild Monkeys, Mt. Huangshan, China. We used all-occurrence sampling to record play behaviors and candidate play signals based on an ethogram. We predicted that play groups would use multiple candidate play signals in a variety of contexts and in association with the number of audience members in proximity to the players and play bout length. In the 283 playful interactions we scored, juvenile and infant macaques used multiple body and facial candidate play signals. Our data showed that juvenile and infant Tibetan macaques use a versatile repertoire of play behaviors and signals to sustain play.

Looking into Children's Play Communities

ERIC Educational Resources Information Center

Mabry, Mark; Fucigna, Carolee

2009-01-01

Play, particularly children's sociodramatic play, is the cornerstone of early childhood classrooms in the United States. Early childhood educators learn and expound mantras of "the value of play," "play-based programs," "children learning through play," and "play as child's work." They strive to promote the importance of making a place for play in…

Transforming Play: An Analysis of First-, Third-, and Fifth-Graders' Play.

ERIC Educational Resources Information Center

Bagley, Donna M.; Chaille, Christine

1996-01-01

Compared children's play with transformational objects (vehicles that change to robots) to play with representational objects (cars and figures). Found that those playing with transformers engaged in more parallel play and manipulative activity, while those with representational objects displayed more social play and more symbolic play. Found no…

Play Therapy: Facilitative Use of Child's Play in Elementary School Counseling.

ERIC Educational Resources Information Center

Landreth, Garry L.

1987-01-01

Reviews five major developments in play therapy: psychoanalysis, release therapy, relationship therapy, nondirective therapy, and play therapy in school settings. Suggests ways school counselors can use play therapy. Describes play therapy facilities, location selection, and play materials. Lists objectives of play therapy and how teachers can aid…

Beyond Physical Activity: The Importance of Play and Nature-Based Play Spaces for Children's Health and Development.

PubMed

Herrington, Susan; Brussoni, Mariana

2015-12-01

The reduction of child obesity continues to be a challenge worldwide. Research indicates that playing outdoors, particularly in natural play spaces, boosts children's physical activity, potentially decreasing childhood obesity. We present evidence that natural play spaces also provide for more diverse forms of play for children of varying ages and competencies. This is crucial because play spaces designed expressly for physical activity may not increase physical activity among less active children. Moreover, when researchers only examine physical activity in play, they overlook the valuable contributions that play makes to other aspects of children's health and development. To enhance research on children and their play environments, we introduce the theory of play affordances. To assist in the creation of more natural play spaces, we describe the Seven Cs, an evidence-based approach for designing children's play spaces that promotes diverse play. We end with some preliminary insights from our current research using the Seven Cs to illustrate the connections between play, nature, and children's healthy development.

Body signals used during social play in captive immature western lowland gorillas.

PubMed

Weigel, Erin A; Berman, Carol M

2018-05-01

The play face is a well-established play signal in nonhuman primates that functions to invite play and convey a playful intent. However, recent evidence indicates that some species display repertoires of play signals that may have more specific meanings related to particular aspects of play. Furthermore, previous studies have inconsistently categorized gorilla behaviors as play signals versus actual play. Here we aim to identify behaviors displayed by two immature captive western lowland gorillas (Gorilla gorilla gorilla) at the Buffalo Zoo that meet three necessary criteria to be considered play signals. Specifically, we (1) investigate whether 21 candidate signals are significantly different from actual play behaviors, (2) and from similar signals used in non-play contexts, and (3) determine whether they predict the occurrence of social play. The results indicate that at least 18 of the 21 candidate signals have strong support for classification as play signals. These findings represent first steps in determining the function of multiple play signals in gorillas.

Stability of playfulness across environmental settings: a pilot study.

PubMed

Rigby, Patricia; Gaik, Sandy

2007-01-01

The Test of Playfulness (ToP) was used in this pilot study to examine the stability of playfulness of 16 children with cerebral palsy (CP), aged 4-8 years, across three environmental settings: home, community, and school. Each videotaped play segment was scored using the ToP. The ANOVA statistic demonstrated a significant variance (p < 0.05) in the playfulness of the children across the 3 settings. The children were most playful at home and least playful at school (p < 0.05). The variability in playfulness across settings suggests that playful behaviors are influenced by factors external to the child. Eleven children were playful (achieving a positive ToP score) in at least one environment, which demonstrates that they had the capacity to be playful. Their play was supported in some settings and not in others. However, there was a lack of playfulness in 65% of the play segments suggesting that these children experience many barriers to their participation in play. Future research is needed to identify factors that help and hinder the playfulness of children with CP.

Exploring Play/Playfulness and Learning in the Adult and Higher Education Classroom

ERIC Educational Resources Information Center

Tanis, David J.

2012-01-01

Play and playfulness and their role in learning are researched extensively in early childhood education. However, as the child matures into an adult, play and playfulness are given less attention in the teaching and learning process. In adult education, there is very little research about play/playfulness and its significance for learning. Despite…

Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats.

PubMed

Achterberg, E J Marijke; van Kerkhof, Linda W M; Servadio, Michela; van Swieten, Maaike M H; Houwing, Danielle J; Aalderink, Mandy; Driel, Nina V; Trezza, Viviana; Vanderschuren, Louk J M J

2016-02-01

Social play behavior, abundant in the young of most mammalian species, is thought to be important for social and cognitive development. Social play is highly rewarding, and as such, the expression of social play depends on its pleasurable and motivational properties. Since the motivational properties of social play have only sporadically been investigated, we developed a setup in which rats responded for social play under a progressive ratio schedule of reinforcement. Dopaminergic neurotransmission plays a key role in incentive motivational processes, and both dopamine and noradrenaline have been implicated in the modulation of social play behavior. Therefore, we investigated the role of dopamine and noradrenaline in the motivation for social play. Treatment with the psychostimulant drugs methylphenidate and cocaine increased responding for social play, but suppressed its expression during reinforced play periods. The dopamine reuptake inhibitor GBR-12909 increased responding for social play, but did not affect its expression, whereas the noradrenaline reuptake inhibitor atomoxetine decreased responding for social play as well as its expression. The effects of methylphenidate and cocaine on responding for social play, but not their play-suppressant effects, were blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol. In contrast, pretreatment with the α2-adrenoceptor antagonist RX821002 prevented the play-suppressant effect of methylphenidate, but left its effect on responding for social play unaltered. In sum, the present study introduces a novel method to study the incentive motivational properties of social play behavior in rats. Using this paradigm, we demonstrate dissociable roles for dopamine and noradrenaline in social play behavior: dopamine stimulates the motivation for social play, whereas noradrenaline negatively modulates the motivation for social play behavior and its expression.

Play in adult bonobos (Pan paniscus): modality and potential meaning.

PubMed

Palagi, Elisabetta; Paoli, Tommaso

2007-10-01

The aim of this study was to thoroughly investigate social play and its modalities among adult bonobos. We evaluated how play intensity varies according to the sex-class combination of the playmates and we also performed an analysis on social locomotor-rotational movements (L-R play) and contact interactions (C play). Rough and gentle play sessions were performed with comparable frequencies by male-female and female-female adult dyads, with play signals unlikely when the playmates strongly differed in age and in rank position. L-R play rates did not differ according to the sex-combination of the players; in contrast, C play sessions were particularly frequent among females. Play faces (play signals) were significantly higher during C play than L-R play sessions, thus suggesting that playmates assess reciprocally yet safely their relationships by using facial displays to avoid any kind of misunderstanding. Play was positively correlated with grooming and contact sitting interactions, suggesting that it may be used as a social enhancer. Finally, we found no correlation between both play contexts (L-R and C play) and age, size and rank differences of the players. In conclusion, we suggest that bonobos with their egalitarian society, peculiar social structure, and playful tendency represent an attractive testing subject to examine empirically many emerging hypotheses on adult play behavior. (c) 2007 Wiley-Liss, Inc.

Investigating the Function of Play Bows in Dog and Wolf Puppies (Canis lupus familiaris, Canis lupus occidentalis).

PubMed

Byosiere, Sarah-Elizabeth; Espinosa, Julia; Marshall-Pescini, Sarah; Smuts, Barbara; Range, Friederike

2016-01-01

Animals utilize behavioral signals across a range of different contexts in order to communicate with others and produce probable behavioral outcomes. During play animals frequently adopt action patterns used in other contexts. Researchers have therefore hypothesized that play signals have evolved to clarify communicative intent. One highly stereotyped play signal is the canid play bow, but its function remains contested. In order to clarify how canid puppies use play bows, we used data on play bows in immature wolves (ages 2.7-7.8 months) and dogs (ages 2 to 5 months) to test hypotheses evaluated in a previous study of adult dogs. We found that young dogs used play bows similarly to adult dogs; play bows most often occurred after a brief pause in play followed by complementary highly active play states. However, while the relative number of play bows and total observation time was similar between dog and wolf puppies, wolves did not follow this behavioral pattern, as play bows were unsuccessful in eliciting further play activity by the partner. While some similarities for the function of play bows in dog and wolf puppies were documented, it appears that play bows may function differently in wolf puppies in regards to re-initiating play.

Problematic game play: the diagnostic value of playing motives, passion, and playing time in men.

PubMed

Kneer, Julia; Rieger, Diana

2015-04-30

Internet gaming disorder is currently listed in the DSM-not in order to diagnose such a disorder but to encourage research to investigate this phenomenon. Even whether it is still questionable if Internet Gaming Disorder exists and can be judged as a form of addiction, problematic game play is already very well researched to cause problems in daily life. Approaches trying to predict problematic tendencies in digital game play have mainly focused on playing time as a diagnostic criterion. However, motives to engage in digital game play and obsessive passion for game play have also been found to predict problematic game play but have not yet been investigated together. The present study aims at (1) analyzing if obsessive passion can be distinguished from problematic game play as separate concepts, and (2) testing motives of game play, passion, and playing time for their predictive values for problematic tendencies. We found (N = 99 males, Age: M = 22.80, SD = 3.81) that obsessive passion can be conceptually separated from problematic game play. In addition, the results suggest that compared to solely playing time immersion as playing motive and obsessive passion have added predictive value for problematic game play. The implications focus on broadening the criteria in order to diagnose problematic playing.

Problematic Game Play: The Diagnostic Value of Playing Motives, Passion, and Playing Time in Men

PubMed Central

Kneer, Julia; Rieger, Diana

2015-01-01

Internet gaming disorder is currently listed in the DSM—not in order to diagnose such a disorder but to encourage research to investigate this phenomenon. Even whether it is still questionable if Internet Gaming Disorder exists and can be judged as a form of addiction, problematic game play is already very well researched to cause problems in daily life. Approaches trying to predict problematic tendencies in digital game play have mainly focused on playing time as a diagnostic criterion. However, motives to engage in digital game play and obsessive passion for game play have also been found to predict problematic game play but have not yet been investigated together. The present study aims at (1) analyzing if obsessive passion can be distinguished from problematic game play as separate concepts, and (2) testing motives of game play, passion, and playing time for their predictive values for problematic tendencies. We found (N = 99 males, Age: M = 22.80, SD = 3.81) that obsessive passion can be conceptually separated from problematic game play. In addition, the results suggest that compared to solely playing time immersion as playing motive and obsessive passion have added predictive value for problematic game play. The implications focus on broadening the criteria in order to diagnose problematic playing. PMID:25942516

Adult play fighting and potential role of tail signals in ringtailed lemurs (Lemur catta).

PubMed

Palagi, Elisabetta

2009-02-01

Adult strepsirrhines have been completely neglected in the study of animal play. I focused on adult play fighting and the role of tail-play as a signal in ringtailed lemurs (Lemur catta). Tail-play is performed during play fighting, when lemurs anoint or, more rarely, wave their tails toward the playmate. During the prereproductive period, male and female lemurs engaged in play fighting with comparable frequencies, as was expected to occur in monomorphic species such as L. catta. The dyads showing low aggression rates engaged most frequently in play fighting, and polyadic play was frequently performed. Signals seem to be important in avoiding escalation to real aggression, especially when the playfulness of performers can be misunderstood by recipients. Tail-play was most frequent (a) in the dyads with low grooming rates (low familiarity degree) and (b) during the most risky play sessions (polyadic ones). Thus, tail-play can be considered as a useful tool for play communication in ringtailed lemurs. Copyright 2009 APA, all rights reserved.

Two-Character Plays for Student Actors: A Collection of 15 One-Act Plays.

ERIC Educational Resources Information Center

Mauro, Robert

Designed for workshop or classroom use, this collection of short plays for two actors is a source of material for auditions and readings and a valuable training tool for acting classes. The collection contains plays for men only, plays for women only, plays for men and women, plays with a wide variety of roles, plays of comedy and serious drama,…

Play Therapy: A Review

ERIC Educational Resources Information Center

Porter, Maggie L.; Hernandez-Reif, Maria; Jessee, Peggy

2009-01-01

This article discusses the current issues in play therapy and its implications for play therapists. A brief history of play therapy is provided along with the current play therapy approaches and techniques. This article also touches on current issues or problems that play therapists may face, such as interpreting children's play, implementing…

Pretending to Play or Playing to Pretend: The Case of Autism.

PubMed

Kasari, Connie; Chang, Ya-Chih; Patterson, Stephanie

2013-01-01

An article by Angeline S. Lillard and others published in the January 2013 issue of Psychological Bulletin about the impact of pretend play on child development raised a number of issues about play studies and child psychology. They claimed that, contrary to current theories on the subject, the evidence of many studies does not support causal explanations of play's relationship to most childhood development. In this article, authors Kasari, Chang, and Patterson review these arguments about play and devlopment in relation to children with autism-children who show specific deficits in pretend play. They argue that the study of these children provides a unique opportunity to consider which elements in play are important and how play skills are associated with different periods of child development. They conclude that, because pretend play requires intervention for the majority of children with autism, improving pretense in these children may shed more light on the causal impact of pretense on later developing skills in children. Key words: child development and pretend play; children with autism; funtional play; intervention in play; symbol play.

Forms of vitality play in infancy.

PubMed

Español, Silvia; Martínez, Mauricio; Bordoni, Mariana; Camarasa, Rosario; Carretero, Soledad

2014-12-01

In this paper we report a qualitative study based on the constant comparative method to initiate the systematic study of forms of vitality play. This is an unnoticed non-figurative play frame linked to early social play and temporal arts in which child and adult elaborate the dynamics of their own movements and sounds in a repetition-variation form. In the introduction we present the theoretical underpinnings and the sporadic observations we have done in previous studies. Then, by the iterative observations of the recorded material of a longitudinal case study on play during the third year of life, we generated the general category of forms of vitality play and four subcategories of display modes of forms of vitality play (improvised forms of vitality play, ritualized forms of vitality play, forms of vitality play combined with pretend play, and forms of vitality play combined with role playing) which are illustrated with descriptive narratives. We discuss the properties of the developed categories, the limits of the present study, and the need to continue systematizing the research on this playful activity.

On play and playing.

PubMed

Rudan, Dusko

2013-12-01

The paper offers a review of the development of the concept of play and playing. The true beginnings of the development of the theories of play are set as late as in the 19th century. It is difficult to define play as such; it may much more easily be defined through its antipode--work. In the beginning, play used to be connected with education; it was not before Freud's theory of psychoanalysis and Piaget's developmental psychology that the importance of play in a child's development began to be explained in more detail. The paper further tackles the role of play in the adult age. Detailed attention is paid to psychodynamic and psychoanalytic authors, in particular D. W. Winnicott and his understanding of playing in the intermediary (transitional) empirical or experiential space. In other words, playing occupies a space and time of its own. The neuroscientific concept of playing is also tackled, in the connection with development as well.

Characterization of juvenile play in rats: importance of sex of self and sex of partner.

PubMed

Argue, Kathryn J; McCarthy, Margaret M

2015-01-01

Juvenile social play is observed in many mammalian species, and its disruption in several neuropsychiatric disorders has greatly increased interest in understanding the origins and sources of variability in this behavior. We quantified social play behavior in juvenile rats and investigated the impact of sex and familiarity of the play partner. Sex differences in play behavior were investigated by comparing males and females from either same- or mixed-sex pairs with data pooled over 12 days of analysis. Whether play was altered based on the sex of the play partner was assessed using a paired analysis to compare play with a same- or opposite-sex play partner for both males and females. Additionally, a repeated measures design was utilized to determine whether play changed with increasing age. On postnatal day 33, a novel play partner was introduced. We used a repeated measures analysis to compare postnatal day 33 with the previous day. These approaches were used to assess the effects of age, sex, sex of partner, and familiarity of partner on total social play behavior as well as how play was broken down into components, such as pouncing, pinning, chasing, and boxing. There were sex differences in total frequency of play, and specific parameters of play behavior, such as chasing, pouncing, pinning, and boxing. Additionally, males significantly altered their play behavior in response to the sex of their play partner, whereas females were more sensitive to the familiarity of the play partner. This study provides critical groundwork for uncovering factors that regulate social play behavior and can be used to guide future mechanistic based work.

Robots and ICT to support play in children with severe physical disabilities: a systematic review.

PubMed

van den Heuvel, Renée J F; Lexis, Monique A S; Gelderblom, Gert Jan; Jansens, Rianne M L; de Witte, Luc P

2015-09-02

Play is an essential part of children's lives. Children with physical disabilities experience difficulties in play, especially those with severe physical disabilities. With the progress of innovative technology, the possibilities to support play are increasing. The purpose of this literature study is to gain insight into the aims, control options and commercial availability of information and communication technology (ICT) and robots to support play (especially play for the sake of play) in children with severe physical disabilities. A systematic literature search in the databases PubMed, CINAHL, IEEE and ERIC was carried out. Titles and abstracts were assessed independently by three reviewers. In addition, studies were selected using Google Scholar, conference proceedings and reference lists. Three main groups of technology for play could be distinguished: robots (n = 8), virtual reality systems (n = 15) and computer systems (n = 4). Besides, ICT and robots developed for specific therapy or educational goals using play-like activities, five of the in total 27 technologies in this study described the aim of "play for play's sake". Many ICT systems and robots to support play in children with physical disabilities were found. Numerous technologies use play-like activities to achieve therapeutic or educational goals. Robots especially are used for "play for play's sake". Implications for Rehabilitation This study gives insight into the aims, control options and commercial availability for application of robots and ICT to support play in children with severe physical disabilities. This overview can be used in both the fields of rehabilitation and special education to search for new innovative intervention options and it can stimulate them to use these innovative play materials. Especially robots may have great potential in supporting "play for play's sake".

Effects of Spatial Scale on Cognitive Play in Preschool Children.

ERIC Educational Resources Information Center

Delong, Alton J.; And Others

1994-01-01

Examined effects of a reduced-scale play environment on the temporal aspects of complex play behavior. Children playing with playdough in a 7 x 5 x 5-foot structure began complex play more quickly, played in longer segments, and spent slightly more time in complex play than when in full-size conditions, suggesting that scale-reduced environments…

Play and Mate Preference: Testing the Signal Theory of Adult Playfulness

ERIC Educational Resources Information Center

Chick, Garry; Yarnal, Careen; Purrington, Andrew

2012-01-01

The overwhelming majority of play research concerns juveniles. However, a full understanding of the phenomenon requires knowledge of play and playfulness across the life spans of those animals, including humans, who play in adulthood. The authors investigate a theory of play based on Darwin's concept of sexual selection that may account for the…

Forms of vitality play and symbolic play during the third year of life.

PubMed

Español, Silvia; Bordoni, Mariana; Martínez, Mauricio; Camarasa, Rosario; Carretero, Soledad

2015-08-01

This article focuses on the development of forms of vitality play, a recently described type of play, and links it to the development of symbolic play, one of the most studied types of play in developmental psychology. Two adult-infant dyads were videotaped longitudinally during in-house free play meetings every 15 days during the third year of life. Convergence technique was applied in order to accelerate the longitudinal study. A total of 17h 48min were registered in 28 sessions. An observational code with categories of forms of vitality play (a non-figurative play frame in which child and adult play together with the dynamics of their own movements and sounds in a repetition-variation form), symbolic play, and categories of combined patterns of both types of play was applied. The rate of each play was calculated for different age periods. Forms of vitality play is present at a constant rate during the third year of life. Symbolic play flourishes during this period. Combined play patterns are not the most frequent but are present from the beginning to the end of the third year. We suggest that FoVP favours intimate and intersubjective experiences essential to the understanding and the development of the interpersonal world; that it can be thought of as a good runway for the development of symbolic play; and that it prepares the child to participate in the temporal arts that belong to his culture. Copyright © 2015 Elsevier Inc. All rights reserved.

Play: early and eternal.

PubMed Central

Mears, C E; Harlow, H F

1975-01-01

A systematic 12-week investigation of development of play behavior was conducted with eight socially reared rhesus monkey infants. A new, basic and primary play form termed self-motion play or peragration was identified and examined. This behavior follows a human model which includes a wide range of pleasurable activities involving motion of the body through space, e.g., rocking, swinging, running, leaping, and water or snow skiing. It can be argued that self-motion play is the initial primate play form and because of its persistence constitutes a reinforcing agent for maintaining many complex patterns and even pastimes. Monkey self-motion play in the present study was divided into five separate patterns in order to compare the relative importance of social and individual peragration play, the role of apparatus and the overall developmental relationships between the different individual and social self-motion play patterns. The data showed that from 90 to 180 days of age self-motion play was independent of other forms of play, that individual self-motion play appeared earlier and with significantly greater increases in frequency than did social self-motion play, and that apparatus was a necessary component for significant increases in social self-motion play. Other findings were that self-motion play existed independent of locomotion and, though initiated by exploration, was separate from it. Therapeutic implications of self-motion play were discussed. Images PMID:1057178

MEASUREMENT OF FATHER-CHILD ROUGH-AND-TUMBLE PLAY AND ITS RELATIONS TO CHILD BEHAVIOR.

PubMed

Stgeorge, Jennifer; Freeman, Emily

2017-11-01

Although there is increasing evidence of paternal influence on child outcomes such as language and cognition, researchers are not yet clear on the features of father-child play that are most valuable in terms of child development. Physical play such as rough and tumble play (RTP) is a favored type of father-child play in Western societies that has been linked to children's socioemotional competence. It is important, therefore, to determine the implications of this play for child development. In this review and meta-analysis, associations between father-child physical play and child behavior were examined. The review also focused on study methods. Sixteen studies are reviewed, N = 1,521 father-child dyads, 35% boys. Study characteristics such as definitions of physical play, play settings, play measures, and coding were examined. The meta-analysis found weak to moderate population effects for links between father-child physical play and child aggression, social competence, emotional skills, and self-regulation. Research investigating the effect of father-child physical play on children's development will be improved when definitions clearly identify the nature of play, settings facilitate boisterous play, and measures include frequency and quality of play interactions. This play shows promise as an enhancer of positive father-child relationships and a catalyst for child development. © 2017 Michigan Association for Infant Mental Health.

Picture me playing: increasing pretend play dialogue of children with autism spectrum disorders.

PubMed

Murdock, Linda C; Hobbs, Jan Q

2011-07-01

This study examined the effectiveness of the Picture Me Playing intervention for increasing the play dialogue of preschool children with ASD during pretend play opportunities with typical peers. Picture Me Playing is a pictorially enhanced, script based intervention targeting character role play through a narrative vignette. A single-treatment counterbalanced design was utilized to contrast the performance of intervention and comparison groups, followed by within-subject analysis. Results indicated significant increases in play dialogue represented by both scripted and novel utterances. Results generalized to an unscripted play opportunity with novel toys.

The Play Experiences of Preschool Children from a Low-socio-economic Rural Community in Worcester, South Africa.

PubMed

Bartie, Michelle; Dunnell, Alex; Kaplan, Jesse; Oosthuizen, Dianka; Smit, Danielle; van Dyk, Anchen; Cloete, Lizahn; Duvenage, Mia

2016-06-01

Occupational therapists believe that play is a child's main occupation and is considered essential for healthy motor, cognitive and emotional development. However, play spaces and activities in low socio-economic areas are often different to those provided in structured occupational therapy treatment environments. The main objective was to determine play opportunities, activities, equipment, toys and the play environment for 5- to 6-year-olds living in a low-socio-economic community outside a small town in South Africa, in order to understand the nature of play in this environment better. Participant observation together with an adapted photovoice method to capture the play experience was used. Data was analysed using inductive content analysis. Two global themes emerged from the results: "neighbourhood children find ways to play" and "context influences play". Children were given ample opportunity to play and participated in extensive outdoor play. Their games were highly social and involved the imaginative use of found items as toys. Play was also used to make sense of social hazards. An understanding of play in a low-income context has implications for the development of future play assessments and the provision of play therapy in these communities. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

The relative cost of children's physical play.

PubMed

Pellegrini; Horvat; Huberty

1998-04-01

There has been a long-standing debate regarding the functions of play during childhood. An important, but neglected, first step in this debate entails documenting the costs associated with play. In this study we analysed energetic costs (expressed in terms of caloric expenditure) associated with physical play in four field experiments of play in primary school children. Experiment 1 established the concurrent validity of an observational check list to estimate caloric expenditure of children's physical play. Experiment 2 compared caloric expenditure of the play (defined as all behaviour exhibited during play time) for two age groups of children during playtime outdoors and during indoor sedentary activity; caloric expenditure of outdoor activity was greater and was significantly correlated with ambient temperature. In experiment 3, children were observed during indoor play to control for the influence of ambient temperature. Outdoor physical play was more energetically costly than indoor physical play. In experiment 4, children's behaviour was observed outdoors and caloric expenditure for play, games and other activities was compared. Physical play was more costly than other forms of behaviour and games. Estimates of total energetic costs of play ranged from 6 to 15%. Results are discussed in terms of the relatively low caloric costs of play. Copyright 1998 The Association for the Study of Animal Behaviour. Copyright 1998 The Association for the Study of Animal Behaviour.

Young Children's Development of Scientific Knowledge Through the Combination of Teacher-Guided Play and Child-Guided Play

NASA Astrophysics Data System (ADS)

Sliogeris, Marija; Almeida, Sylvia Christine

2017-09-01

Play-based approaches to science learning allow children to meaningfully draw on their everyday experiences and activities as they explore science concepts in context. Acknowledging the crucial role of the teacher in facilitating science learning through play, the purpose of this qualitative study was to examine how teacher-guided play, in conjunction with child-guided play, supports children's development of science concepts. While previous research on play-based science learning has mainly focused on preschool settings, this study explores the possibilities of play-based approaches to science in primary school contexts. Using a qualitative methodology grounded in the cultural-historical theoretical perspective, children's learning was examined during a science learning sequence that combined teacher-guided and child-guided play. This study revealed that the teacher-guided play explicitly introduced science concepts which children then used and explored in subsequent child-guided play. However, intentional teaching during the child-guided play continued to be important. Play-based approaches to science allowed children to make sense of the science concepts using familiar, everyday knowledge and activities. It became evident that the expectations and values communicated through classroom practices influenced children's learning through play.

Psychiatrists' Perceptions of Role-Playing Games.

PubMed

Lis, Eric; Chiniara, Carl; Biskin, Robert; Montoro, Richard

2015-09-01

The literature has seen a surge in research on the mental health impacts of technologies such as Facebook, video games, and massively-multiplayer online role-playing games such as World of Warcraft, but little is known regarding the mental health impact of non-video role-playing games, such as Dungeons & Dragons. The present study examines how psychiatrists' perceive role-playing games and whether they play them. Psychiatrists at a tertiary care centre in Canada completed a questionnaire assessing history of playing role-playing games and whether they associate them with psychopathology. Forty-eight psychiatrists responded. Twenty-three percent have played a role-playing game over their lifetimes. Twenty-two percent believed there was an association between psychopathology and role-playing games. A majority of psychiatrists who responded do not associate role-playing games with psychopathology. Implications for clinical practice and future research are discussed.

Relations between parents' interactive style in dyadic and triadic play and toddlers' symbolic capacity.

PubMed

Keren, M; Feldman, R; Namdari-Weinbaum, I; Spitzer, S; Tyano, S

2005-10-01

Play has a major role in the evaluation and treatment of young children referred to mental health clinicians. The present study examined parental correlates of preschoolers' symbolic play during dyadic and triadic play interactions. Boys' play contained more aggressive themes, and girls' contained more nurturing themes. Mothers displayed more caring themes during play with both sons and daughters, and fathers displayed more repair and construction themes. Mothers' and fathers' facilitative- creative interaction style in dyadic play predicted the level of the child's symbolic play. Co-parenting style marked by cooperation and autonomy predicted symbolic play during a triadic family session. Child intelligence predicted symbolic play beyond the parent's style during triadic but not dyadic interactions. The findings have implications for early intervention directed at increasing symbolic play in young children.

Inclusive indoor play: an approach to developing inclusive design guidelines.

PubMed

Mullick, Abir

2013-01-01

The purpose of the Inclusive Indoor Play study was to learn about indoor play and develop design guidelines to inform design of inclusive playthings. Children with and without disabilities, parents, teachers, therapists, daycare owners and designers. Focus group interviews; Children's drawings; and Indoor play simulation. The major findings suggest that: 1) play should encourage a child's creativity and develop imagination, 2) inclusive play concept must be employed to design playthings for children with wide age group, 3) inclusive designs improve usability, broaden market appeal, and increase user base, and 4) customizable playthings help children with and without disabilities personalize play situations. Three play principles provide new directions to designing inclusive playthings: 1) offer many play opportunities, 2) provide many modes of play, and 3) include many levels of play challenges. Inclusive Design Guidelines were developed from the findings of three studies: Focus group interviews, Children's drawings, and Play simulation. The guidelines served as useful tools for inclusive design and they were employed to design of six indoor playthings. The playthings were instrumental in promoting social inclusion and they met the criteria of the Inclusive Indoor Play project.

Mother-child play in children with Down syndrome and typical development

PubMed Central

Venuti, P.; de Falco, S.; Esposito, G.; Bornstein, Marc H.

2014-01-01

The present study compares child solitary and collaborative play with mother in 21 children with Down syndrome (DS) and 33 mental-age-matched typically developing (TD) children. In solitary play, children with DS showed less exploratory but similar symbolic play compared to TD children. From solitary to collaborative play, children with DS increased their exploratory play attaining the same level as TD children; Pretense significantly increased from solitary to collaborative play only in TD children . Differences between mothers’ play in the two groups mirrored those between their children. Child and mother play in both groups showed similar attunement and synchrony. Mothers contribute to the play development of children with DS through their own adaptation to their children’s limitations and potentialities alike. PMID:19642713

Towards Play Pedagogy: Supporting Teacher Play Practices with a Teacher Guide about Socio-Dramatic and Imaginative Play

ERIC Educational Resources Information Center

Loizou, Eleni

2017-01-01

Drawing on the work of Vygotsky on scaffolding play and research on teacher intervention and mature forms of play, we have developed a teacher guide about play which frames children's role and scenario development and provides a teacher play intervention schema. The research question explored in this study is "How does a teacher guide,…

Greek Preschool Children's Playful Behaviour: Assessment and Correlation with Personal and Family Characteristics

ERIC Educational Resources Information Center

Rentzou, Konstantina

2013-01-01

All children and young people need to play. The impulse to play is innate. Yet, the pure essence of play is playfulness a notion not new, yet limitedly researched. Playfulness refers to the individual style each child has to play, which is linked to personality descriptors and attributes. The present study had a twofold aim. On the one hand, it…

Sequential Transition Patterns of Preschoolers' Social Interactions during Child-Initiated Play: Is Parallel-Aware Play a Bidirectional Bridge to Other Play States?

ERIC Educational Resources Information Center

Robinson, Clyde C.; Anderson, Genan T.; Porter, Christin L.; Hart, Craig, H.; Wouden-Miller, Melissa

2003-01-01

Explored the simultaneous sequential transition patterns of preschoolers' social play within classroom settings. Found that the proportion of social-play states did not vary during play episodes even when accounting for type of activity center, gender, and SES. Found a reciprocal relationship between parallel-aware and other social-play states…

The Non-linear Trajectory of Change in Play Profiles of Three Children in Psychodynamic Play Therapy.

PubMed

Halfon, Sibel; Çavdar, Alev; Orsucci, Franco; Schiepek, Gunter K; Andreassi, Silvia; Giuliani, Alessandro; de Felice, Giulio

2016-01-01

Aim: Even though there is substantial evidence that play based therapies produce significant change, the specific play processes in treatment remain unexamined. For that purpose, processes of change in long-term psychodynamic play therapy are assessed through a repeated systematic assessment of three children's "play profiles," which reflect patterns of organization among play variables that contribute to play activity in therapy, indicative of the children's coping strategies, and an expression of their internal world. The main aims of the study are to investigate the kinds of play profiles expressed in treatment, and to test whether there is emergence of new and more adaptive play profiles using dynamic systems theory as a methodological framework. Methods and Procedures: Each session from the long-term psychodynamic treatment (mean number of sessions = 55) of three 6-year-old good outcome cases presenting with Separation Anxiety were recorded, transcribed and coded using items from the Children's Play Therapy Instrument (CPTI), created to assess the play activity of children in psychotherapy, generating discrete and measurable units of play activity arranged along a continuum of four play profiles: "Adaptive," "Inhibited," "Impulsive," and "Disorganized." The play profiles were clustered through K -means Algorithm, generating seven discrete states characterizing the course of treatment and the transitions between these states were analyzed by Markov Transition Matrix, Recurrence Quantification Analysis (RQA) and odds ratios comparing the first and second halves of psychotherapy. Results: The Markov Transitions between the states scaled almost perfectly and also showed the ergodicity of the system, meaning that the child can reach any state or shift to another one in play. The RQA and odds ratios showed two trends of change, first concerning the decrease in the use of "less adaptive" strategies, second regarding the reduction of play interruptions. Conclusion: The results support that these children express different psychic states in play, which can be captured through the lens of play profiles, and begin to modify less dysfunctional profiles over the course of treatment. The methodology employed showed the productivity of treating psychodynamic play therapy as a complex system, taking advantage of non-linear methods to study psychotherapeutic play activity.

Are 50-kHz calls used as play signals in the playful interactions of rats? II. Evidence from the effects of devocalization.

PubMed

Kisko, Theresa M; Himmler, Brett T; Himmler, Stephanie M; Euston, David R; Pellis, Sergio M

2015-02-01

During playful interactions, juvenile rats emit many 50-kHz ultrasonic vocalizations, which are associated with a positive affective state. In addition, these calls may also serve a communicative role - as play signals that promote playful contact. Consistent with this hypothesis, a previous study found that vocalizations are more frequent prior to playful contact than after contact is terminated. The present study uses devocalized rats to test three predictions arising from the play signals hypothesis. First, if vocalizations are used to facilitate contact, then in pairs of rats in which one is devocalized, the higher frequency of pre-contact calling should only be present when the intact rat is initiating the approach. Second, when both partners in a playing pair are devocalized, the frequency of play should be reduced and the typical pattern of playful wrestling disrupted. Finally, when given a choice to play with a vocal and a non-vocal partner, rats should prefer to play with the one able to vocalize. The second prediction was supported in that the frequency of playful interactions as well as some typical patterns of play was disrupted. Even though the data for the other two predictions did not produce the expected findings, they support the conclusion that, in rats, 50-kHz calls are likely to function to maintain a playful mood and for them to signal to one another during play fighting. Copyright © 2014 Elsevier B.V. All rights reserved.

Children's play: a tool for public health interventions.

PubMed

Vitale, Anna

2011-10-01

All children need to spend some time playing outdoors. In Northern European countries, schools are equipped with outdoor facilities where children can play during breaks between lessons. The Italian school system, oriented to a mnemonic learning approach, has attached a poor importance to the role of playing for kindergarten age children, and Italian kindergartens are not so well equipped for children's active play. Furthermore, Italian teachers and parents worried that while playing outdoors, children might catch a cold or hurt themselves, and discourage active play outside. The equipment of kindergartens' open spaces with wooden games, where children can play in the morning or after school, resulted in children's increased time of playing outdoors. These playgrounds are also used during vacation day time by children to play and in the evenings, for theatrical and animation events. Finally, watching over their children when playing, "forced" parents to talk to each other creating a social network.

Teaching about the French Revolution--A Play.

ERIC Educational Resources Information Center

Pezone, Michael

2002-01-01

Presents a play about the French Revolution, discussing how the play was used within a global history course. States that students read the play, work in groups to rewrite the play, and perform their version of the play. Includes key questions that are asked of the students. (CMK)

Tutored-Untutored Dramatic Play: Similarities and Differences.

ERIC Educational Resources Information Center

Mellou, Eleni

1994-01-01

Untutored dramatic play (free, undirected play) and tutored dramatic play (creative drama) involve interaction, symbolic transformation, and imagination as children enact roles in imaginary situations. Both types of play serve the child's artistic, emotional, and intellectual needs. They differ in the degree of spontaneity, consistency of play,…

A longitudinal study of children's outside play using family environment and perceived physical environment as predictors.

PubMed

Remmers, Teun; Broeren, Suzanne M L; Renders, Carry M; Hirasing, Remy A; van Grieken, Amy; Raat, Hein

2014-06-16

A natural and cheap way of increasing children's physical activity is stimulating unstructured outside play. This study examined whether characteristics of the family and perceived physical environment were associated with the duration of children's outside play. Parents participating in the "Be Active, Eat Right" cluster RCT control group (N = 2007) provided information on potential predictors of outside play (i.e. family and perceived physical environment) of their 5-year-old child by questionnaire. Child outside play was assessed by parental reports both at five and seven years. Linear regression analyses, adjusted for seasonality, were performed to evaluate associations between potential predictors and child outside play. Linear mixed models were fitted to evaluate the relationship between potential predictors and the development of outside play over two years, with season entered as a random factor. Family environment was the strongest construct predicting child outside play, while parent perceived physical environment had no significant association with child outside play. Parental habit strength and the presence of rules were the strongest predictors of increased outside play. Parent perceived difficulty in improving child outside play was the strongest predictor of decreased outside play. Family environment predicted child outside play and not perceived physical environment. Parental rules and habit strength regarding improving outside play were associated with an improvement of child's engagement in outside play.

Play in a Hospital. Why...? How...?

ERIC Educational Resources Information Center

Play Schools Association, New York, NY.

This pamphlet provides guidelines for hospital play and recreation programs for children. A rationale for providing play activities for hospitalized children is developed and an administrative perspective on play in the hospital setting is Presented. A hospital play program initiated in 1957 by the Play Schools Association at an initial equipment…

Playing My Heart Out: Original Play as Adventure.

ERIC Educational Resources Information Center

Donaldson, O. Fred

1999-01-01

"Original" play denotes play that is pre-cultural--before conceptualizations and learned responses. Four anecdotes about play with an infant with Down's syndrome, a child with leukemia, a lioness, and a dying woman illustrate the connections between beings and between the ordinary and the sacred during trusting, fearless, playful encounters. (SV)

Leisure Today--the Many Faces of Play.

ERIC Educational Resources Information Center

Hudson, Susan D.; And Others

1995-01-01

This series of papers examines the role of play from various angles, discussing play as an essential human function and universal experience, the role of play in developing cultural values and awareness, a symbolic interactionist view of play, early therapeutic recreation specialists, and the direction of commercialized play. (SM)

Word Play: Scaffolding Language Development through Child-Directed Play

ERIC Educational Resources Information Center

Wasik, Barbara A.; Jacobi-Vessels, Jill L.

2017-01-01

Play is an important activity in young children's lives. It is how children explore their world and build knowledge. Although free play, which is play that is totally child directed, contributes to children's learning, self-regulation and motivation, adults' participation in children's play is critical in their development, especially their…

Training in Fantasy Play.

ERIC Educational Resources Information Center

Smith, Peter K.

1983-01-01

Outcomes of fantasy play training were compared with those of nonfantasy/skills training in English nursery classes and play groups. Children receiving fantasy play training engaged in cooperative play more than did those receiving skills training, played more often in larger subgroups, and were more physically active. Most effects were present at…

Child's Play: Revisiting Play in Early Childhood Settings.

ERIC Educational Resources Information Center

Dau, Elizabeth, Ed.; Jones, Elizabeth, Ed.

Noting that play is an essential aspect of learning for young children, this book presents a collection of articles on children's play in Australia. Part 1, "Play, Development, and Learning," contains the following chapters: (1) "The Role of Play in Development and Learning" (Ann Glover); (2) "Stop, Look, and Listen:…

Designing Out the Play: Accessibility and Playfulness in Inclusive Play.

PubMed

Holt, Raymond; Beckett, Angharad

2017-01-01

Play is an important part of child development, yet disabled children are often excluded from the opportunity to play, either due to lack of accessible toys and games, or social pressures. This paper presents a case study reflecting on the development of Button Bash: a switch accessible game intended to encourage inclusive play between disabled and non-disabled children. In particular, the paper focuses on how changes intended to make the game more accessible tended to make it less playful, and reflects on the relationship between playfulness and accessibility.

Alibis for Adult Play

PubMed Central

2017-01-01

The social meanings of play sit at odds with norms of responsible and productive adult conduct. To be “caught” playing as an adult therefore risks embarrassment. Still, many designers want to create enjoyable, nonembarrassing play experiences for adults. To address this need, this article reads instances of spontaneous adult play through the lens of Erving Goffman’s theory of the interaction order to unpack conditions and strategies for nonembarrassing adult play. It identifies established frames, segregated audiences, scripts supporting smooth performance, managing audience awareness, role distancing, and, particularly, alibis for play: Adults routinely provide alternative, adult-appropriate motives to account for their play, such as child care, professional duties, creative expression, or health. Once legitimized, the norms and rules of play themselves then provide an alibi for behavior that would risk being embarrassing outside play. PMID:29706842