Sample records for unified model um

  1. Evaluation of Unified Model Microphysics in High-resolution NWP Simulations Using Polarimetric Radar Observations

    NASA Astrophysics Data System (ADS)

    Johnson, Marcus; Jung, Youngsun; Dawson, Daniel; Supinie, Timothy; Xue, Ming; Park, Jongsook; Lee, Yong-Hee

    2018-07-01

    The UK Met Office Unified Model (UM) is employed by many weather forecasting agencies around the globe. This model is designed to run across spatial and time scales and known to produce skillful predictions for large-scale weather systems. However, the model has only recently begun running operationally at horizontal grid spacings of ˜1.5 km [e.g., at the UK Met Office and the Korea Meteorological Administration (KMA)]. As its microphysics scheme was originally designed and tuned for large-scale precipitation systems, we investigate the performance of UM microphysics to determine potential inherent biases or weaknesses. Two rainfall cases from the KMA forecasting system are considered in this study: a Changma (quasi-stationary) front, and Typhoon Sanba (2012). The UM output is compared to polarimetric radar observations in terms of simulated polarimetric radar variables. Results show that the UM generally underpredicts median reflectivity in stratiform rain, producing high reflectivity cores and precipitation gaps between them. This is partially due to the diagnostic rain intercept parameter formulation used in the one-moment microphysics scheme. Model drop size is generally both underand overpredicted compared to observations. UM frozen hydrometeors favor generic ice (crystals and snow) rather than graupel, which is reasonable for Changma and typhoon cases. The model performed best with the typhoon case in terms of simulated precipitation coverage.

  2. Optimization of microphysics in the Unified Model, using the Micro-genetic algorithm.

    NASA Astrophysics Data System (ADS)

    Jang, J.; Lee, Y.; Lee, H.; Lee, J.; Joo, S.

    2016-12-01

    This study focuses on parameter optimization of microphysics in the Unified Model (UM) using the Micro-genetic algorithm (Micro-GA). We need the optimization of microphysics in UM. Because, Microphysics in the Numerical Weather Prediction (NWP) model is important to Quantitative Precipitation Forecasting (QPF). The Micro-GA searches for optimal parameters on the basis of fitness function. The five parameters are chosen. The target parameters include x1, x2 related to raindrop size distribution, Cloud-rain correlation coefficient, Surface droplet number and Droplet taper height. The fitness function is based on the skill score that is BIAS and Critical Successive Index (CSI). An interface between UM and Micro-GA is developed and applied to three precipitation cases in Korea. The cases are (ⅰ) heavy rainfall in the Southern area because of typhoon NAKRI, (ⅱ) heavy rainfall in the Youngdong area, and (ⅲ) heavy rainfall in the Seoul metropolitan area. When the optimized result is compared to the control result (using the UM default value, CNTL), the optimized result leads to improvements in precipitation forecast, especially for heavy rainfall of the late forecast time. Also, we analyze the skill score of precipitation forecasts in terms of various thresholds of CNTL, Optimized result, and experiments on each optimized parameter for five parameters. Generally, the improvement is maximized when the five optimized parameters are used simultaneously. Therefore, this study demonstrates the ability to improve Korean precipitation forecasts by optimizing microphysics in UM.

  3. The East Asian Atmospheric Water Cycle and Monsoon Circulation in the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Rodríguez, José M.; Milton, Sean F.; Marzin, Charline

    2017-10-01

    In this study the low-level monsoon circulation and observed sources of moisture responsible for the maintenance and seasonal evolution of the East Asian monsoon are examined, studying the detailed water budget components. These observational estimates are contrasted with the Met Office Unified Model (MetUM) climate simulation performance in capturing the circulation and water cycle at a variety of model horizontal resolutions and in fully coupled ocean-atmosphere simulations. We study the role of large-scale circulation in determining the hydrological cycle by analyzing key systematic errors in the model simulations. MetUM climate simulations exhibit robust circulation errors, including a weakening of the summer west Pacific Subtropical High, which leads to an underestimation of the southwesterly monsoon flow over the region. Precipitation and implied diabatic heating biases in the South Asian monsoon and Maritime Continent region are shown, via nudging sensitivity experiments, to have an impact on the East Asian monsoon circulation. By inference, the improvement of these tropical biases with increased model horizontal resolution is hypothesized to be a factor in improvements seen over East Asia with increased resolution. Results from the annual cycle of the hydrological budget components in five domains show a good agreement between MetUM simulations and ERA-Interim reanalysis in northern and Tibetan domains. In simulations, the contribution from moisture convergence is larger than in reanalysis, and they display less precipitation recycling over land. The errors are closely linked to monsoon circulation biases.

  4. Design Of Computer Based Test Using The Unified Modeling Language

    NASA Astrophysics Data System (ADS)

    Tedyyana, Agus; Danuri; Lidyawati

    2017-12-01

    The Admission selection of Politeknik Negeri Bengkalis through interest and talent search (PMDK), Joint Selection of admission test for state Polytechnics (SB-UMPN) and Independent (UM-Polbeng) were conducted by using paper-based Test (PBT). Paper Based Test model has some weaknesses. They are wasting too much paper, the leaking of the questios to the public, and data manipulation of the test result. This reasearch was Aimed to create a Computer-based Test (CBT) models by using Unified Modeling Language (UML) the which consists of Use Case diagrams, Activity diagram and sequence diagrams. During the designing process of the application, it is important to pay attention on the process of giving the password for the test questions before they were shown through encryption and description process. RSA cryptography algorithm was used in this process. Then, the questions shown in the questions banks were randomized by using the Fisher-Yates Shuffle method. The network architecture used in Computer Based test application was a client-server network models and Local Area Network (LAN). The result of the design was the Computer Based Test application for admission to the selection of Politeknik Negeri Bengkalis.

  5. National Centers for Environmental Prediction

    Science.gov Websites

    resolution at T574 becomes ~ 23 km T382 Spectral truncation equivalent to horizontal resolution ~37 km T254 Spectral truncation equivalent to horizontal resolution ~50-55 km T190 Spectral truncation equivalent to horizontal resolution ~70 km T126 Spectral truncation equivalent to horizontal resolution ~100 km UM Unified

  6. Emergency preparedness for the accidental release of radionuclides from the Uljin Nuclear Power Plant in Korea.

    PubMed

    Park, Soon-Ung; Lee, In-Hye; Joo, Seung Jin; Ju, Jae-Won

    2017-12-01

    Site specific radionuclide dispersion databases were archived for the emergency response to the hypothetical releases of 137 Cs from the Uljin nuclear power plant in Korea. These databases were obtained with the horizontal resolution of 1.5 km in the local domain centered the power plant site by simulations of the Lagrangian Particle Dispersion Model (LPDM) with the Unified Model (UM)-Local Data Assimilation Prediction System (LDAPS). The Eulerian Dispersion Model-East Asia (EDM-EA) with the UM-Global Data Assimilation Prediction System (UM-GDAPS) meteorological models was used to get dispersion databases in the regional domain. The LPDM model was performed for a year with a 5-day interval yielding 72 synoptic time-scale cases in a year. For each case hourly mean near surface concentrations, hourly mean column integrated concentrations, hourly total depositions for 5 consecutive days were archived by the LPDM model in the local domain and by the EDM-EA model in the regional domain of Asia. Among 72 synoptic cases in a year the worst synoptic case that showed the highest mean surface concentration averaged for 5 days in the LPDM model domain was chosen to illustrate the emergency preparedness to the hypothetical accident at the site. The simulated results by the LPDM model with the 137 Cs emission rate of the Fukushima nuclear power plant accident for the first 5-day period were found to be able to provide prerequisite information for the emergency response to the early phase of the accident whereas those of the EDM-EA model could provide information required for the environmental impact assessment of the accident in the regional domain. The archived site-specific database of 72 synoptic cases in a year could have a great potential to be used as a prognostic information on the emergency preparedness for the early phase of accident. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. The effect of metallicity on the atmospheres of exoplanets with fully coupled 3D hydrodynamics, equilibrium chemistry, and radiative transfer

    NASA Astrophysics Data System (ADS)

    Drummond, B.; Mayne, N. J.; Baraffe, I.; Tremblin, P.; Manners, J.; Amundsen, D. S.; Goyal, J.; Acreman, D.

    2018-05-01

    In this work, we have performed a series of simulations of the atmosphere of GJ 1214b assuming different metallicities using the Met Office Unified Model (UM). The UM is a general circulation model (GCM) that solves the deep, non-hydrostatic equations of motion and uses a flexible and accurate radiative transfer scheme, based on the two-stream and correlated-k approximations, to calculate the heating rates. In this work we consistently couple a well-tested Gibbs energy minimisation scheme to solve for the chemical equilibrium abundances locally in each grid cell for a general set of elemental abundances, further improving the flexibility and accuracy of the model. As the metallicity of the atmosphere is increased we find significant changes in the dynamical and thermal structure, with subsequent implications for the simulated phase curve. The trends that we find are qualitatively consistent with previous works, though with quantitative differences. We investigate in detail the effect of increasing the metallicity by splitting the mechanism into constituents, involving the mean molecular weight, the heat capacity and the opacities. We find the opacity effect to be the dominant mechanism in altering the circulation and thermal structure. This result highlights the importance of accurately computing the opacities and radiative transfer in 3D GCMs.

  8. Exploring the climate of Proxima B with the Met Office Unified Model

    NASA Astrophysics Data System (ADS)

    Boutle, Ian A.; Mayne, Nathan J.; Drummond, Benjamin; Manners, James; Goyal, Jayesh; Hugo Lambert, F.; Acreman, David M.; Earnshaw, Paul D.

    2017-05-01

    We present results of simulations of the climate of the newly discovered planet Proxima Centauri B, performed using the Met Office Unified Model (UM). We examine the responses of both an "Earth-like" atmosphere and simplified nitrogen and trace carbon dioxide atmosphere to the radiation likely received by Proxima Centauri B. Additionally, we explore the effects of orbital eccentricity on the planetary conditions using a range of eccentricities guided by the observational constraints. Overall, our results are in agreement with previous studies in suggesting Proxima Centauri B may well have surface temperatures conducive to the presence of liquid water. Moreover, we have expanded the parameter regime over which the planet may support liquid water to higher values of eccentricity (≳0.1) and lower incident fluxes (881.7 W m-2) than previous work. This increased parameter space arises because of the low sensitivity of the planet to changes in stellar flux, a consequence of the stellar spectrum and orbital configuration. However, we also find interesting differences from previous simulations, such as cooler mean surface temperatures for the tidally-locked case. Finally, we have produced high-resolution planetary emission and reflectance spectra, and highlight signatures of gases vital to the evolution of complex life on Earth (oxygen, ozone and carbon dioxide).

  9. Does air-sea coupling influence model projections of the effects of the Paris Agreement?

    NASA Astrophysics Data System (ADS)

    Klingaman, Nicholas; Suckling, Emma; Sutton, Rowan; Dong, Buwen

    2017-04-01

    The 2015 Paris Agreement includes the long-term goal to hold global-mean temperature to "well below 2°C above pre-industrial levels", with the further stated aim of limiting the global-mean warming to 1.5°C, in the belief that this would "significantly reduce the risks and impacts of climate change". However, it is not clear which risks and impacts would be avoided, or reduced, by achieving a 1.5°C warming instead of a 2.0°C warming. Initial efforts to quantify changes in risk have focused on analysis of existing CMIP5 simulations at levels of global-mean warming close to 1.5°C or 2.0°C, by taking averages over ≈20 year periods. This framework suffers from several drawbacks, however, including the effect of model internal multi-decadal variability, the influence of coupled-model systematic errors on regional circulation patterns, and the presence of a warming trend across the averaging period (i.e., the model is not in steady state). To address these issues, the "Half a degree Additional warming, Prognosis and Projected Impacts" (HAPPI) project is performing large ensembles of atmosphere-only experiments with prescribed sea-surface temperatures (SSTs) for present-day and 1.5°C and 2.0°C scenarios. While these experiments reduce the complications from a limited dataset and coupled-model systematic errors, the use of atmosphere-only models neglects feedbacks between the atmosphere and ocean, which may have substantial effects on the representation of local and regional extremes, and hence on the response of these extremes to global-mean warming. We introduce a set of atmosphere-ocean coupled simulations that incorporate much of the HAPPI experiment design, yet retain a representation of air-sea feedbacks. We use the Met Office Unified Model Global Ocean Mixed Layer (MetUM-GOML) model, which comprises the MetUM atmospheric model coupled to many columns of the one-dimensional K Profile Parameterization mixed-layer ocean. Critically, the MetUM-GOML ocean mean state can be controlled by prescribed, seasonally varying corrections to temperature and salinity, which substantially reduce SST biases without damping variability. This allows the present-day MetUM-GOML experiment to have a ocean mean state very close to the observed climatology (global RMSE ≈ 0.25°C). We perform three 150-year experiments with MetUM-GOML for (a) present-day (1976-2005 climatology) and for future scenarios with global-mean temperatures (b) 1.5°C and (c) 2.0°C above pre-industrial levels. For (b) and (c), we achieve these warming levels by increasing the CO2 concentrations in MetUM-GOML, as well as by adjusting the prescribed sea ice using change factors derived from a transient simulation with the fully coupled Met Office model. We analyse projected global and regional changes in temperature, precipitation and atmospheric circulation in our MetUM-GOML simulations, focusing on seasonal means, multi-annual persistence of seasonal extremes (e.g., the probability of consecutive wet summers) and intra-seasonal extremes (e.g., heatwaves, droughts, floods). To identify the influence of air-sea coupling on these projections, we compare the MetUM-GOML simulations to 150-year atmosphere-only simulations with prescribed daily SSTs from the corresponding MetUM-GOML runs. This comparison demonstrates whether atmosphere-ocean feedbacks influence the projections of changes hydro-meteorological extremes in a warmer world, as well as whether these feedbacks affect the assessment of the impacts avoided by limiting global-mean temperature change to 1.5°C. Our results will inform the choice of model framework for, and hence the experiment design of, further efforts to characterise the response to a fixed global-mean temperature increase, as well as future climate-change attribution experiments.

  10. Observable Signatures of Wind-driven Chemistry with a Fully Consistent Three-dimensional Radiative Hydrodynamics Model of HD 209458b

    NASA Astrophysics Data System (ADS)

    Drummond, B.; Mayne, N. J.; Manners, J.; Carter, A. L.; Boutle, I. A.; Baraffe, I.; Hébrard, É.; Tremblin, P.; Sing, D. K.; Amundsen, D. S.; Acreman, D.

    2018-03-01

    We present a study of the effect of wind-driven advection on the chemical composition of hot-Jupiter atmospheres using a fully consistent 3D hydrodynamics, chemistry, and radiative transfer code, the Met Office Unified Model (UM). Chemical modeling of exoplanet atmospheres has primarily been restricted to 1D models that cannot account for 3D dynamical processes. In this work, we couple a chemical relaxation scheme to the UM to account for the chemical interconversion of methane and carbon monoxide. This is done consistently with the radiative transfer meaning that departures from chemical equilibrium are included in the heating rates (and emission) and hence complete the feedback between the dynamics, thermal structure, and chemical composition. In this Letter, we simulate the well studied atmosphere of HD 209458b. We find that the combined effect of horizontal and vertical advection leads to an increase in the methane abundance by several orders of magnitude, which is directly opposite to the trend found in previous works. Our results demonstrate the need to include 3D effects when considering the chemistry of hot-Jupiter atmospheres. We calculate transmission and emission spectra, as well as the emission phase curve, from our simulations. We conclude that gas-phase nonequilibrium chemistry is unlikely to explain the model–observation discrepancy in the 4.5 μm Spitzer/IRAC channel. However, we highlight other spectral regions, observable with the James Webb Space Telescope, where signatures of wind-driven chemistry are more prominant.

  11. A new Infrared Atmospheric Sounding Interferometer channel selection and assessment of its impact on Met Office NWP forecasts

    NASA Astrophysics Data System (ADS)

    Noh, Young-Chan; Sohn, Byung-Ju; Kim, Yoonjae; Joo, Sangwon; Bell, William; Saunders, Roger

    2017-11-01

    A new set of Infrared Atmospheric Sounding Interferometer (IASI) channels was re-selected from 314 EUMETSAT channels. In selecting channels, we calculated the impact of the individually added channel on the improvement in the analysis outputs from a one-dimensional variational analysis (1D-Var) for the Unified Model (UM) data assimilation system at the Met Office, using the channel score index (CSI) as a figure of merit. Then, 200 channels were selected in order by counting each individual channel's CSI contribution. Compared with the operationally used 183 channels for the UM at the Met Office, the new set shares 149 channels, while the other 51 channels are new. Also examined is the selection from the entropy reduction method with the same 1D-Var approach. Results suggest that channel selection can be made in a more objective fashion using the proposed CSI method. This is because the most important channels can be selected across the whole IASI observation spectrum. In the experimental trial runs using the UM global assimilation system, the new channels had an overall neutral impact in terms of improvement in forecasts, as compared with results from the operational channels. However, upper-tropospheric moist biases shown in the control run with operational channels were significantly reduced in the experimental trial with the newly selected channels. The reduction of moist biases was mainly due to the additional water vapor channels, which are sensitive to the upper-tropospheric water vapor.

  12. Verification of the NWP models operated at ICM, Poland

    NASA Astrophysics Data System (ADS)

    Melonek, Malgorzata

    2010-05-01

    Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw (ICM) started its activity in the field of NWP in May 1997. Since this time the numerical weather forecasts covering Central Europe have been routinely published on our publicly available website. First NWP model used in ICM was hydrostatic Unified Model developed by the UK Meteorological Office. It was a mesoscale version with horizontal resolution of 17 km and 31 levels in vertical. At present two NWP non-hydrostatic models are running in quasi-operational regime. The main new UM model with 4 km horizontal resolution, 38 levels in vertical and forecats range of 48 hours is running four times a day. Second, the COAMPS model (Coupled Ocean/Atmosphere Mesoscale Prediction System) developed by the US Naval Research Laboratory, configured with the three nested grids (with coresponding resolutions of 39km, 13km and 4.3km, 30 vertical levels) are running twice a day (for 00 and 12 UTC). The second grid covers Central Europe and has forecast range of 84 hours. Results of the both NWP models, ie. COAMPS computed on 13km mesh resolution and UM, are verified against observations from the Polish synoptic stations. Verification uses surface observations and nearest grid point forcasts. Following meteorological elements are verified: air temperature at 2m, mean sea level pressure, wind speed and wind direction at 10 m and 12 hours accumulated precipitation. There are presented different statistical indices. For continous variables Mean Error(ME), Mean Absolute Error (MAE) and Root Mean Squared Error (RMSE) in 6 hours intervals are computed. In case of precipitation the contingency tables for different thresholds are computed and some of the verification scores such as FBI, ETS, POD, FAR are graphically presented. The verification sample covers nearly one year.

  13. Diagnosing the radiative and chemical contributions to future changes in tropical column ozone with the UM-UKCA chemistry-climate model

    NASA Astrophysics Data System (ADS)

    Keeble, James; Bednarz, Ewa M.; Banerjee, Antara; Abraham, N. Luke; Harris, Neil R. P.; Maycock, Amanda C.; Pyle, John A.

    2017-11-01

    Chemical and dynamical drivers of trends in tropical total-column ozone (TCO3) for the recent past and future periods are explored using the UM-UKCA (Unified Model HadGEM3-A (Hewitt et al., 2011) coupled with the United Kingdom Chemistry and Aerosol scheme) chemistry-climate model. A transient 1960-2100 simulation is analysed which follows the representative concentration pathway 6.0 (RCP6.0) emissions scenario for the future. Tropical averaged (10° S-10° N) TCO3 values decrease from the 1970s, reach a minimum around 2000 and return to their 1980 values around 2040, consistent with the use and emission of halogenated ozone-depleting substances (ODSs), and their later controls under the Montreal Protocol. However, when the ozone column is subdivided into three partial columns (PCO3) that cover the upper stratosphere (PCO3US), lower stratosphere (PCO3LS) and troposphere (PCO3T), significant differences in the temporal behaviour of the partial columns are seen. Modelled PCO3T values under the RCP6.0 emissions scenario increase from 1960 to 2000 before remaining approximately constant throughout the 21st century. PCO3LS values decrease rapidly from 1960 to 2000 and remain constant from 2000 to 2050, before gradually decreasing further from 2050 to 2100 and never returning to their 1980s values. In contrast, PCO3US values decrease from 1960 to 2000, before increasing rapidly throughout the 21st century and returning to 1980s values by ˜ 2020, and reach significantly higher values by 2100. Using a series of idealised UM-UKCA time-slice simulations with concentrations of well-mixed greenhouse gases (GHGs) and halogenated ODS species set to either year 2000 or 2100 levels, we examine the main processes that drive the PCO3 responses in the three regions and assess how these processes change under different emission scenarios. Finally, we present a simple, linearised model to describe the future evolution of tropical stratospheric column ozone values based on terms representing time-dependent abundances of GHG and halogenated ODS.

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenfeld, Daniel; Wang, Hailong; Rasch, Philip J.

    Numerical simulations described in previous studies showed that adding cloud condensation nuclei to marine stratocumulus can prevent their breakup from closed into open cells. Additional analyses of the same simulations show that the suppression of rain is well described in terms of cloud drop effective radius (re). Rain is initiated when re near cloud top is around 12-14 um. Cloud water starts to get depleted when column-maximum rain intensity (Rmax) exceeds 0.1 mm h-1. This happens when cloud-top re reaches 14 um. Rmax is mostly less than 0.1 mm h-1 at re<14 um, regardless of the cloud water path, butmore » increases rapidly when re exceeds 14 um. This is in agreement with recent aircraft observations and theoretical observations in convective clouds so that the mechanism is not limited to describing marine stratocumulus. These results support the hypothesis that the onset of significant precipitation is determined by the number of nucleated cloud drops and the height (H) above cloud base within the cloud that is required for cloud drops to reach re of 14 um. In turn, this can explain the conditions for initiation of significant drizzle and opening of closed cells providing the basis for a simple parameterization for GCMs that unifies the representation of both precipitating and non-precipitating clouds as well as the transition between them. Furthermore, satellite global observations of cloud depth (from base to top), and cloud top re can be used to derive and validate this parameterization.« less

  15. Climateprediction.com: Public Involvement, Multi-Million Member Ensembles and Systematic Uncertainty Analysis

    NASA Astrophysics Data System (ADS)

    Stainforth, D. A.; Allen, M.; Kettleborough, J.; Collins, M.; Heaps, A.; Stott, P.; Wehner, M.

    2001-12-01

    The climateprediction.com project is preparing to carry out the first systematic uncertainty analysis of climate forecasts using large ensembles of GCM climate simulations. This will be done by involving schools, businesses and members of the public, and utilizing the novel technology of distributed computing. Each participant will be asked to run one member of the ensemble on their PC. The model used will initially be the UK Met Office's Unified Model (UM). It will be run under Windows and software will be provided to enable those involved to view their model output as it develops. The project will use this method to carry out large perturbed physics GCM ensembles and thereby analyse the uncertainty in the forecasts from such models. Each participant/ensemble member will therefore have a version of the UM in which certain aspects of the model physics have been perturbed from their default values. Of course the non-linear nature of the system means that it will be necessary to look not just at perturbations to individual parameters in specific schemes, such as the cloud parameterization, but also to the many combinations of perturbations. This rapidly leads to the need for very large, perhaps multi-million member ensembles, which could only be undertaken using the distributed computing methodology. The status of the project will be presented and the Windows client will be demonstrated. In addition, initial results will be presented from beta test runs using a demo release for Linux PCs and Alpha workstations. Although small by comparison to the whole project, these pilot results constitute a 20-50 member perturbed physics climate ensemble with results indicating how climate sensitivity can be substantially affected by individual parameter values in the cloud scheme.

  16. On the climate model simulation of Indian monsoon low pressure systems and the effect of remote disturbances and systematic biases

    NASA Astrophysics Data System (ADS)

    Levine, Richard C.; Martin, Gill M.

    2018-06-01

    Monsoon low pressure systems (LPS) are synoptic-scale systems forming over the Indian monsoon trough region, contributing substantially to seasonal mean summer monsoon rainfall there. Many current global climate models (GCMs), including the Met Office Unified Model (MetUM), show deficient rainfall in this region, much of which has previously been attributed to remote systematic biases such as excessive equatorial Indian Ocean (EIO) convection, while also substantially under-representing LPS and associated rainfall as they travel westwards across India. Here the sources and sensitivities of LPS to local, remote and short-timescale forcing are examined, in order to understand the poor representation in GCMs. An LPS tracking method is presented using TRACK feature tracking software for comparison between re-analysis data-sets, MetUM GCM and regional climate model (RCM) simulations. RCM simulations, at similar horizontal resolution to the GCM and forced with re-analysis data at the lateral boundaries, are carried out with different domains to examine the effects of remote biases. The results suggest that remote biases contribute significantly to the poor simulation of LPS in the GCM. As these remote systematic biases are common amongst many current GCMs, it is likely that GCMs are intrinsically capable of representing LPS, even at relatively low resolution. The main problem areas are time-mean excessive EIO convection and poor representation of precursor disturbances transmitted from the Western Pacific. The important contribution of the latter is established using RCM simulations forced by climatological 6-hourly lateral boundary conditions, which also highlight the role of LPS in moving rainfall from steep orography towards Central India.

  17. A description and evaluation of an air quality model nested within global and regional composition-climate models using MetUM

    NASA Astrophysics Data System (ADS)

    Neal, Lucy S.; Dalvi, Mohit; Folberth, Gerd; McInnes, Rachel N.; Agnew, Paul; O'Connor, Fiona M.; Savage, Nicholas H.; Tilbee, Marie

    2017-11-01

    There is a clear need for the development of modelling frameworks for both climate change and air quality to help inform policies for addressing these issues simultaneously. This paper presents an initial attempt to develop a single modelling framework, by introducing a greater degree of consistency in the meteorological modelling framework by using a two-step, one-way nested configuration of models, from a global composition-climate model (GCCM) (140 km resolution) to a regional composition-climate model covering Europe (RCCM) (50 km resolution) and finally to a high (12 km) resolution model over the UK (AQUM). The latter model is used to produce routine air quality forecasts for the UK. All three models are based on the Met Office's Unified Model (MetUM). In order to better understand the impact of resolution on the downscaling of projections of future climate and air quality, we have used this nest of models to simulate a 5-year period using present-day emissions and under present-day climate conditions. We also consider the impact of running the higher-resolution model with higher spatial resolution emissions, rather than simply regridding emissions from the RCCM. We present an evaluation of the models compared to in situ air quality observations over the UK, plus a comparison against an independent 1 km resolution gridded dataset, derived from a combination of modelling and observations, effectively producing an analysis of annual mean surface pollutant concentrations. We show that using a high-resolution model over the UK has some benefits in improving air quality modelling, but that the use of higher spatial resolution emissions is important to capture local variations in concentrations, particularly for primary pollutants such as nitrogen dioxide and sulfur dioxide. For secondary pollutants such as ozone and the secondary component of PM10, the benefits of a higher-resolution nested model are more limited and reasons for this are discussed. This study highlights the point that the resolution of models is not the only factor in determining model performance - consistency between nested models is also important.

  18. The mental health care model in Brazil: analyses of the funding, governance processes, and mechanisms of assessment.

    PubMed

    Trapé, Thiago Lavras; Campos, Rosana Onocko

    2017-03-23

    This study aims to analyze the current status of the mental health care model of the Brazilian Unified Health System, according to its funding, governance processes, and mechanisms of assessment. We have carried out a documentary analysis of the ordinances, technical reports, conference reports, normative resolutions, and decrees from 2009 to 2014. This is a time of consolidation of the psychosocial model, with expansion of the health care network and inversion of the funding for community services with a strong emphasis on the area of crack cocaine and other drugs. Mental health is an underfunded area within the chronically underfunded Brazilian Unified Health System. The governance model constrains the progress of essential services, which creates the need for the incorporation of a process of regionalization of the management. The mechanisms of assessment are not incorporated into the health policy in the bureaucratic field. There is a need to expand the global funding of the area of health, specifically mental health, which has been shown to be a successful policy. The current focus of the policy seems to be archaic in relation to the precepts of the psychosocial model. Mechanisms of assessment need to be expanded. Analisar o estágio atual do modelo de atenção à saúde mental do Sistema Único de Saúde, segundo seu financiamento, processos de governança e mecanismos de avaliação. Foi realizada uma análise documental de portarias, informes técnicos, relatórios de conferência, resoluções e decretos de 2009 a 2014. Trata-se de um momento de consolidação do modelo psicossocial, com ampliação da rede assistencial, inversão de financiamento para serviços comunitários com forte ênfase na área de crack e outras drogas. A saúde mental é uma área subfinanciada dentro do subfinanciamento crônico do Sistema Único de Saúde. O modelo de governança constrange o avanço de serviços essenciais, havendo a necessidade da incorporação de um processo de regionalização da gestão. Os mecanismos avaliativos no campo burocrático se mostram pouco incorporados à política de saúde. É necessário ampliar o financiamento global da saúde e específico da saúde mental, que vem se constituindo como uma política exitosa. O foco atual da política se mostra anacrônico aos preceitos do modelo psicossocial. Aponta-se a necessidade de ampliação de mecanismos avaliativos.

  19. On the q-type distributions

    NASA Astrophysics Data System (ADS)

    Nadarajah, Saralees; Kotz, Samuel

    2007-04-01

    Various q-type distributions have appeared in the physics literature in the recent years, see e.g. L.C. Malacarne, R.S. Mendes, E. K. Lenzi, q-exponential distribution in urban agglomeration, Phys. Rev. E 65, (2002) 017106. S.M.D. Queiros, On a possible dynamical scenario leading to a generalised Gamma distribution, in xxx.lanl.gov-physics/0411111. U.M.S. Costa, V.N. Freire, L.C. Malacarne, R.S. Mendes, S. Picoli Jr., E.A. de Vasconcelos, E.F. da Silva Jr., An improved description of the dielectric breakdown in oxides based on a generalized Weibull distribution, Physica A 361, (2006) 215. S. Picoli, Jr., R.S. Mendes, L.C. Malacarne, q-exponential, Weibull, and q-Weibull distributions: an empirical analysis, Physica A 324 (2003) 678-688. A.M.C. de Souza, C. Tsallis, Student's t- and r- distributions: unified derivation from an entropic variational principle, Physica A 236 (1997) 52-57. It is pointed out in the paper that many of these are the same as or particular cases of what has been known in the statistics literature. Several of these statistical distributions are discussed and references provided. We feel that this paper could be of assistance for modeling problems of the type considered by L.C. Malacarne, R.S. Mendes, E. K. Lenzi, q-exponential distribution in urban agglomeration, Phys. Rev. E 65, (2002) 017106. S.M.D. Queiros, On a possible dynamical scenario leading to a generalised Gamma distribution, in xxx.lanl.gov-physics/0411111. U.M.S. Costa, V.N. Freire, L.C. Malacarne, R.S. Mendes, S. Picoli Jr., E.A. de Vasconcelos, E.F. da Silva Jr., An improved description of the dielectric breakdown in oxides based on a generalized Weibull distribution, Physica A 361, (2006) 215. S. Picoli, Jr., R.S. Mendes, L.C. Malacarne, q-exponential, Weibull, and q-Weibull distributions: an empirical analysis, Physica A 324 (2003) 678-688. A.M.C. de Souza, C. Tsallis, Student's t- and r- distributions: unified derivation from an entropic variational principle, Physica A 236 (1997) 52-57 and others.

  20. GUDM: Automatic Generation of Unified Datasets for Learning and Reasoning in Healthcare.

    PubMed

    Ali, Rahman; Siddiqi, Muhammad Hameed; Idris, Muhammad; Ali, Taqdir; Hussain, Shujaat; Huh, Eui-Nam; Kang, Byeong Ho; Lee, Sungyoung

    2015-07-02

    A wide array of biomedical data are generated and made available to healthcare experts. However, due to the diverse nature of data, it is difficult to predict outcomes from it. It is therefore necessary to combine these diverse data sources into a single unified dataset. This paper proposes a global unified data model (GUDM) to provide a global unified data structure for all data sources and generate a unified dataset by a "data modeler" tool. The proposed tool implements user-centric priority based approach which can easily resolve the problems of unified data modeling and overlapping attributes across multiple datasets. The tool is illustrated using sample diabetes mellitus data. The diverse data sources to generate the unified dataset for diabetes mellitus include clinical trial information, a social media interaction dataset and physical activity data collected using different sensors. To realize the significance of the unified dataset, we adopted a well-known rough set theory based rules creation process to create rules from the unified dataset. The evaluation of the tool on six different sets of locally created diverse datasets shows that the tool, on average, reduces 94.1% time efforts of the experts and knowledge engineer while creating unified datasets.

  1. Modelling total OH reactivity: atmospheric implications of the missing OH sink

    NASA Astrophysics Data System (ADS)

    Ferracci, V.; Archibald, A. T.; Heimann, I.; Pyle, J. A.

    2016-12-01

    The removal of the majority of reactive trace gases emitted into the atmosphere is initiated by reaction with the hydroxyl radical (OH). Over the last decade, a number of field campaigns have measured the chemical loss rate of OH, also known as total OH reactivity, in a variety of regions across the planet, from urban areas to remote forests. In most cases, comparison of the measured total OH reactivity with that calculated from the sum of the individual OH sinks (obtained via the simultaneous detection of species such as VOCs and NOx) highlighted the presence of "missing" reactivity (up to 80 % of the total measured reactivity), indicating that a significant sink of the hydroxyl radical is currently not accounted for in tropospheric oxidation schemes. Potential candidates for the missing OH reactivity are previously undetected biogenic VOCs, reactive intermediates of the oxidation of known biogenic VOCs (mainly isoprene), or a combination of the two. In this work the Met Office's Unified Model with the United Kingdom Chemistry and Aerosols scheme (UM-UKCA) was used to investigate the potential impacts of a simulated missing OH sink. UM-UKCA is a chemistry-climate model which includes detailed tropospheric chemistry derived from a combination of the JPL-NASA and IUPAC kinetic evaluations as well as the Master Chemical Mechanism database. The missing OH sink was simulated in a number of scenarios: initially, by including in the model chemical reactions that were only recently characterised (e.g., peroxy radicals + OH), then by adding a new chemical tracer, along with its reaction with OH, that would account for most of the missing reactivity observed in the various campaigns across the globe. Sensitivity of the model to the abundance and regional distribution of the new chemical tracer, and to the kinetics and hypothetical products of its reaction with OH are discussed, as well as the impacts of the missing OH sink on the tropospheric ozone budget and methane lifetime, with associated implications for air quality and global warming respectively.

  2. An Estimation Procedure for the Structural Parameters of the Unified Cognitive/IRT Model.

    ERIC Educational Resources Information Center

    Jiang, Hai; And Others

    L. V. DiBello, W. F. Stout, and L. A. Roussos (1993) have developed a new item response model, the Unified Model, which brings together the discrete, deterministic aspects of cognition favored by cognitive scientists, and the continuous, stochastic aspects of test response behavior that underlie item response theory (IRT). The Unified Model blends…

  3. A Unified Approach to Modeling Multidisciplinary Interactions

    NASA Technical Reports Server (NTRS)

    Samareh, Jamshid A.; Bhatia, Kumar G.

    2000-01-01

    There are a number of existing methods to transfer information among various disciplines. For a multidisciplinary application with n disciplines, the traditional methods may be required to model (n(exp 2) - n) interactions. This paper presents a unified three-dimensional approach that reduces the number of interactions from (n(exp 2) - n) to 2n by using a computer-aided design model. The proposed modeling approach unifies the interactions among various disciplines. The approach is independent of specific discipline implementation, and a number of existing methods can be reformulated in the context of the proposed unified approach. This paper provides an overview of the proposed unified approach and reformulations for two existing methods. The unified approach is specially tailored for application environments where the geometry is created and managed through a computer-aided design system. Results are presented for a blended-wing body and a high-speed civil transport.

  4. The Development of Cadastral Domain Model Oriented at Unified Real Estate Registration of China Based on Ontology

    NASA Astrophysics Data System (ADS)

    Li, M.; Zhu, X.; Shen, C.; Chen, D.; Guo, W.

    2012-07-01

    With the certain regulation of unified real estate registration taken by the Property Law and the step-by-step advance of simultaneous development in urban and rural in China, it is the premise and foundation to clearly specify property rights and their relations in promoting the integrated management of urban and rural land. This paper aims at developing a cadastral domain model oriented at unified real estate registration of China from the perspective of legal and spatial, which set up the foundation for unified real estate registration, and facilitates the effective interchange of cadastral information and the administration of land use. The legal cadastral model is provided based on the analysis of gap between current model and the demand of unified real estate registration, which implies the restrictions between different rights. Then the new cadastral domain model is constructed based on the legal cadastral domain model and CCDM (van Oosterom et al., 2006), which integrate real estate rights of urban land and rural land. Finally, the model is validated by a prototype system. The results show that the model is applicable for unified real estate registration in China.

  5. Thermodynamics of Anharmonic Systems: Uncoupled Mode Approximations for Molecules

    DOE PAGES

    Li, Yi-Pei; Bell, Alexis T.; Head-Gordon, Martin

    2016-05-26

    The partition functions, heat capacities, entropies, and enthalpies of selected molecules were calculated using uncoupled mode (UM) approximations, where the full-dimensional potential energy surface for internal motions was modeled as a sum of independent one-dimensional potentials for each mode. The computational cost of such approaches scales the same with molecular size as standard harmonic oscillator vibrational analysis using harmonic frequencies (HO hf). To compute thermodynamic properties, a computational protocol for obtaining the energy levels of each mode was established. The accuracy of the UM approximation depends strongly on how the one-dimensional potentials of each modes are defined. If the potentialsmore » are determined by the energy as a function of displacement along each normal mode (UM-N), the accuracies of the calculated thermodynamic properties are not significantly improved versus the HO hf model. Significant improvements can be achieved by constructing potentials for internal rotations and vibrations using the energy surfaces along the torsional coordinates and the remaining vibrational normal modes, respectively (UM-VT). For hydrogen peroxide and its isotopologs at 300 K, UM-VT captures more than 70% of the partition functions on average. By con trast, the HO hf model and UM-N can capture no more than 50%. For a selected test set of C2 to C8 linear and branched alkanes and species with different moieties, the enthalpies calculated using the HO hf model, UM-N, and UM-VT are all quite accurate comparing with reference values though the RMS errors of the HO model and UM-N are slightly higher than UM-VT. However, the accuracies in entropy calculations differ significantly between these three models. For the same test set, the RMS error of the standard entropies calculated by UM-VT is 2.18 cal mol -1 K -1 at 1000 K. By contrast, the RMS error obtained using the HO model and UM-N are 6.42 and 5.73 cal mol -1 K -1, respectively. For a test set composed of nine alkanes ranging from C5 to C8, the heat capacities calculated with the UM-VT model agree with the experimental values to within a RMS error of 0.78 cal mol -1 K -1 , which is less than one-third of the RMS error of the HO hf (2.69 cal mol -1 K -1) and UM-N (2.41 cal mol -1 K -1) models.« less

  6. GUDM: Automatic Generation of Unified Datasets for Learning and Reasoning in Healthcare

    PubMed Central

    Ali, Rahman; Siddiqi, Muhammad Hameed; Idris, Muhammad; Ali, Taqdir; Hussain, Shujaat; Huh, Eui-Nam; Kang, Byeong Ho; Lee, Sungyoung

    2015-01-01

    A wide array of biomedical data are generated and made available to healthcare experts. However, due to the diverse nature of data, it is difficult to predict outcomes from it. It is therefore necessary to combine these diverse data sources into a single unified dataset. This paper proposes a global unified data model (GUDM) to provide a global unified data structure for all data sources and generate a unified dataset by a “data modeler” tool. The proposed tool implements user-centric priority based approach which can easily resolve the problems of unified data modeling and overlapping attributes across multiple datasets. The tool is illustrated using sample diabetes mellitus data. The diverse data sources to generate the unified dataset for diabetes mellitus include clinical trial information, a social media interaction dataset and physical activity data collected using different sensors. To realize the significance of the unified dataset, we adopted a well-known rough set theory based rules creation process to create rules from the unified dataset. The evaluation of the tool on six different sets of locally created diverse datasets shows that the tool, on average, reduces 94.1% time efforts of the experts and knowledge engineer while creating unified datasets. PMID:26147731

  7. Connecting spatial and temporal scales of tropical precipitation in observations and the MetUM-GA6

    NASA Astrophysics Data System (ADS)

    Martin, Gill M.; Klingaman, Nicholas P.; Moise, Aurel F.

    2017-01-01

    This study analyses tropical rainfall variability (on a range of temporal and spatial scales) in a set of parallel Met Office Unified Model (MetUM) simulations at a range of horizontal resolutions, which are compared with two satellite-derived rainfall datasets. We focus on the shorter scales, i.e. from the native grid and time step of the model through sub-daily to seasonal, since previous studies have paid relatively little attention to sub-daily rainfall variability and how this feeds through to longer scales. We find that the behaviour of the deep convection parametrization in this model on the native grid and time step is largely independent of the grid-box size and time step length over which it operates. There is also little difference in the rainfall variability on larger/longer spatial/temporal scales. Tropical convection in the model on the native grid/time step is spatially and temporally intermittent, producing very large rainfall amounts interspersed with grid boxes/time steps of little or no rain. In contrast, switching off the deep convection parametrization, albeit at an unrealistic resolution for resolving tropical convection, results in very persistent (for limited periods), but very sporadic, rainfall. In both cases, spatial and temporal averaging smoothes out this intermittency. On the ˜ 100 km scale, for oceanic regions, the spectra of 3-hourly and daily mean rainfall in the configurations with parametrized convection agree fairly well with those from satellite-derived rainfall estimates, while at ˜ 10-day timescales the averages are overestimated, indicating a lack of intra-seasonal variability. Over tropical land the results are more varied, but the model often underestimates the daily mean rainfall (partly as a result of a poor diurnal cycle) but still lacks variability on intra-seasonal timescales. Ultimately, such work will shed light on how uncertainties in modelling small-/short-scale processes relate to uncertainty in climate change projections of rainfall distribution and variability, with a view to reducing such uncertainty through improved modelling of small-/short-scale processes.

  8. Unified constitutive models for high-temperature structural applications

    NASA Technical Reports Server (NTRS)

    Lindholm, U. S.; Chan, K. S.; Bodner, S. R.; Weber, R. M.; Walker, K. P.

    1988-01-01

    Unified constitutive models are characterized by the use of a single inelastic strain rate term for treating all aspects of inelastic deformation, including plasticity, creep, and stress relaxation under monotonic or cyclic loading. The structure of this class of constitutive theory pertinent for high temperature structural applications is first outlined and discussed. The effectiveness of the unified approach for representing high temperature deformation of Ni-base alloys is then evaluated by extensive comparison of experimental data and predictions of the Bodner-Partom and the Walker models. The use of the unified approach for hot section structural component analyses is demonstrated by applying the Walker model in finite element analyses of a benchmark notch problem and a turbine blade problem.

  9. A unified approach for determining the ultimate strength of RC members subjected to combined axial force, bending, shear and torsion

    PubMed Central

    Huang, Zhen

    2017-01-01

    This paper uses experimental investigation and theoretical derivation to study the unified failure mechanism and ultimate capacity model of reinforced concrete (RC) members under combined axial, bending, shear and torsion loading. Fifteen RC members are tested under different combinations of compressive axial force, bending, shear and torsion using experimental equipment designed by the authors. The failure mechanism and ultimate strength data for the four groups of tested RC members under different combined loading conditions are investigated and discussed in detail. The experimental research seeks to determine how the ultimate strength of RC members changes with changing combined loads. According to the experimental research, a unified theoretical model is established by determining the shape of the warped failure surface, assuming an appropriate stress distribution on the failure surface, and considering the equilibrium conditions. This unified failure model can be reasonably and systematically changed into well-known failure theories of concrete members under single or combined loading. The unified calculation model could be easily used in design applications with some assumptions and simplifications. Finally, the accuracy of this theoretical unified model is verified by comparisons with experimental results. PMID:28414777

  10. Review and Implementation Status of Prior Defense Business Board Recommendations

    DTIC Science & Technology

    2007-04-01

    Resource Management • Support unified models for shared services , and be prepared to adjust forward approaches for a Unified Medical Command...models for shared services – including by and between Veterans Affairs and Defense, electronic information exchange, disease treatment and prevention...www.dod.mil/dbb/pdf/DBB- Report-on-the-Military.pdf. • Continue to support unified models for shared services – including by and between Veterans Affairs

  11. LDA-Based Unified Topic Modeling for Similar TV User Grouping and TV Program Recommendation.

    PubMed

    Pyo, Shinjee; Kim, Eunhui; Kim, Munchurl

    2015-08-01

    Social TV is a social media service via TV and social networks through which TV users exchange their experiences about TV programs that they are viewing. For social TV service, two technical aspects are envisioned: grouping of similar TV users to create social TV communities and recommending TV programs based on group and personal interests for personalizing TV. In this paper, we propose a unified topic model based on grouping of similar TV users and recommending TV programs as a social TV service. The proposed unified topic model employs two latent Dirichlet allocation (LDA) models. One is a topic model of TV users, and the other is a topic model of the description words for viewed TV programs. The two LDA models are then integrated via a topic proportion parameter for TV programs, which enforces the grouping of similar TV users and associated description words for watched TV programs at the same time in a unified topic modeling framework. The unified model identifies the semantic relation between TV user groups and TV program description word groups so that more meaningful TV program recommendations can be made. The unified topic model also overcomes an item ramp-up problem such that new TV programs can be reliably recommended to TV users. Furthermore, from the topic model of TV users, TV users with similar tastes can be grouped as topics, which can then be recommended as social TV communities. To verify our proposed method of unified topic-modeling-based TV user grouping and TV program recommendation for social TV services, in our experiments, we used real TV viewing history data and electronic program guide data from a seven-month period collected by a TV poll agency. The experimental results show that the proposed unified topic model yields an average 81.4% precision for 50 topics in TV program recommendation and its performance is an average of 6.5% higher than that of the topic model of TV users only. For TV user prediction with new TV programs, the average prediction precision was 79.6%. Also, we showed the superiority of our proposed model in terms of both topic modeling performance and recommendation performance compared to two related topic models such as polylingual topic model and bilingual topic model.

  12. Enhancement of the Acquisition Process for a Combat System-A Case Study to Model the Workflow Processes for an Air Defense System Acquisition

    DTIC Science & Technology

    2009-12-01

    Business Process Modeling BPMN Business Process Modeling Notation SoA Service-oriented Architecture UML Unified Modeling Language CSP...system developers. Supporting technologies include Business Process Modeling Notation ( BPMN ), Unified Modeling Language (UML), model-driven architecture

  13. The influence of the atmospheric boundary layer on nocturnal layers of noctuids and other moths migrating over southern Britain.

    PubMed

    Wood, Curtis R; Chapman, Jason W; Reynolds, Donald R; Barlow, Janet F; Smith, Alan D; Woiwod, Ian P

    2006-03-01

    Insects migrating at high altitude over southern Britain have been continuously monitored by automatically operating, vertical-looking radars over a period of several years. During some occasions in the summer months, the migrants were observed to form well-defined layer concentrations, typically at heights of 200-400 m, in the stable night-time atmosphere. Under these conditions, insects are likely to have control over their vertical movements and are selecting flight heights that are favourable for long-range migration. We therefore investigated the factors influencing the formation of these insect layers by comparing radar measurements of the vertical distribution of insect density with meteorological profiles generated by the UK Meteorological Office's (UKMO) Unified Model (UM). Radar-derived measurements of mass and displacement speed, along with data from Rothamsted Insect Survey light traps, provided information on the identity of the migrants. We present here three case studies where noctuid and pyralid moths contributed substantially to the observed layers. The major meteorological factors influencing the layer concentrations appeared to be: (a) the altitude of the warmest air, (b) heights corresponding to temperature preferences or thresholds for sustained migration and (c) on nights when air temperatures are relatively high, wind-speed maxima associated with the nocturnal jet. Back-trajectories indicated that layer duration may have been determined by the distance to the coast. Overall, the unique combination of meteorological data from the UM and insect data from entomological radar described here show considerable promise for systematic studies of high-altitude insect layering.

  14. Identifying the most hazardous synoptic meteorological conditions for Winter UK PM10 exceedences

    NASA Astrophysics Data System (ADS)

    Webber, Chris; Dacre, Helen; Collins, Bill; Masato, Giacomo

    2016-04-01

    Summary We investigate the relationship between synoptic scale meteorological variability and local scale pollution concentrations within the UK. Synoptic conditions representative of atmospheric blocking highlighted significant increases in UK PM10 concentration ([PM10]), with the probability of exceeding harmful [PM10] limits also increased. Once relationships had been diagnosed, The Met Office Unified Model (UM) was used to replicate these relationships, using idealised source regions of PM10. This helped to determine the PM10 source regions most influential throughout UK PM10 exceedance events and to test whether the model was capable of capturing the relationships between UK PM10 and atmospheric blocking. Finally, a time slice simulation for 2050-2060 helped to answer the question whether PM10 exceedance events are more likely to occur within a changing climate. Introduction Atmospheric blocking events are well understood to lead to conditions, conducive to pollution events within the UK. Literature shows that synoptic conditions with the ability to deflect the Northwest Atlantic storm track from the UK, often lead to the highest UK pollution concentrations. Rossby wave breaking (RWB) has been identified as a mechanism, which results in atmospheric blocking and its relationship with UK [PM10] is explored using metrics designed in Masato, et al., 2013. Climate simulations facilitated by the Met Office UM, enable these relationships between RWB and PM10 to be found within the model. Subsequently the frequency of events that lead to hazardous PM10 concentrations ([PM10]) in a future climate, can be determined, within a climate simulation. An understanding of the impact, meteorology has on UK [PM10] within a changing climate, will help inform policy makers, regarding the importance of limiting PM10 emissions, ensuring safe air quality in the future. Methodology and Results Three Blocking metrics were used to subset RWB into four categories. These RWB categories were all shown to increase UK [PM10] and to increase the probability of exceeding a UK [PM10] threshold, when they occurred within constrained regions. Further analysis highlighted that Omega Block events lead to the greatest probability of exceeding hazardous UK [PM10] limits. These events facilitated the advection of European PM10, while also providing stagnant conditions over the UK, facilitating PM10 accumulation. The Met Office UM was used and nudged to ERA-Interim Reanalysis wind and temperature fields, to replicate the relationships found using observed UK [PM10]. Inert tracers were implemented into the model to replicate UK PM10 source regions throughout Europe. The modelled tracers were seen to correlate well with observed [PM10] and Figure 1 highlights the correlations between a RWB metric and observed (a) and modelled (b) [PM10]. A further free running model simulation highlighted the deficiency of the Met Office UM in capturing RWB frequency, with a reduction over the Northwest Atlantic/ European region. A final time slice simulation was undertaken for the period 2050-2060, using Representative Concentration Pathway 8.5, which attempted to determine the change in frequency of UK PM10 exceedance events, due to changing meteorology, in a future climate. Conclusions RWB has been shown to increase UK [PM10] and to lead to greater probabilities of exceeding a harmful [PM10] threshold. Omega block events have been determined the most hazardous RWB subset and this is due to a combination of European advection and UK stagnation. Simulations within the Met Office UM were undertaken and the relationships seen between observed UK [PM10] and RWB were replicated within the model, using inert tracers. Finally, time slice simulations were undertaken, determining the change in frequency of UK [PM10] exceedance events within a changing climate. References Masato, G., Hoskins, B. J., Woolings, T., 2013; Wave-breaking Characteristics of Northern Hemisphere Winter Blocking: A Two-Dimensional Approach. J. Climate, 26, 4535-4549.

  15. Next Generation Community Based Unified Global Modeling System Development and Operational Implementation Strategies at NCEP

    NASA Astrophysics Data System (ADS)

    Tallapragada, V.

    2017-12-01

    NOAA's Next Generation Global Prediction System (NGGPS) has provided the unique opportunity to develop and implement a non-hydrostatic global model based on Geophysical Fluid Dynamics Laboratory (GFDL) Finite Volume Cubed Sphere (FV3) Dynamic Core at National Centers for Environmental Prediction (NCEP), making a leap-step advancement in seamless prediction capabilities across all spatial and temporal scales. Model development efforts are centralized with unified model development in the NOAA Environmental Modeling System (NEMS) infrastructure based on Earth System Modeling Framework (ESMF). A more sophisticated coupling among various earth system components is being enabled within NEMS following National Unified Operational Prediction Capability (NUOPC) standards. The eventual goal of unifying global and regional models will enable operational global models operating at convective resolving scales. Apart from the advanced non-hydrostatic dynamic core and coupling to various earth system components, advanced physics and data assimilation techniques are essential for improved forecast skill. NGGPS is spearheading ambitious physics and data assimilation strategies, concentrating on creation of a Common Community Physics Package (CCPP) and Joint Effort for Data Assimilation Integration (JEDI). Both initiatives are expected to be community developed, with emphasis on research transitioning to operations (R2O). The unified modeling system is being built to support the needs of both operations and research. Different layers of community partners are also established with specific roles/responsibilities for researchers, core development partners, trusted super-users, and operations. Stakeholders are engaged at all stages to help drive the direction of development, resources allocations and prioritization. This talk presents the current and future plans of unified model development at NCEP for weather, sub-seasonal, and seasonal climate prediction applications with special emphasis on implementation of NCEP FV3 Global Forecast System (GFS) and Global Ensemble Forecast System (GEFS) into operations by 2019.

  16. A unified approach to the analysis and design of elasto-plastic structures with mechanical contact

    NASA Technical Reports Server (NTRS)

    Bendsoe, Martin P.; Olhoff, Niels; Taylor, John E.

    1990-01-01

    With structural design in mind, a new unified variational model has been developed which represents the mechanics of deformation elasto-plasticity with unilateral contact conditions. For a design problem formulated as maximization of the load carrying capacity of a structure under certain constraints, the unified model allows for a simultaneous analysis and design synthesis for a whole range of mechanical behavior.

  17. Unified Plant Growth Model (UPGM). 1. Background, objectives, and vision.

    USDA-ARS?s Scientific Manuscript database

    Since the development of the Environmental Policy Integrated Climate (EPIC) model in 1988, the EPIC-based plant growth code has been incorporated and modified into many agro-ecosystem models. The goals of the Unified Plant Growth Model (UPGM) project are: 1) integrating into one platform the enhance...

  18. Catastrophe Theory: A Unified Model for Educational Change.

    ERIC Educational Resources Information Center

    Cryer, Patricia; Elton, Lewis

    1990-01-01

    Catastrophe Theory and Herzberg's theory of motivation at work was used to create a model of change that unifies and extends Lewin's two separate stage and force field models. This new model is used to analyze the behavior of academics as they adapt to the changing university environment. (Author/MLW)

  19. Development of a non-contextual model for determining the autonomy level of intelligent unmanned systems

    NASA Astrophysics Data System (ADS)

    Durst, Phillip J.; Gray, Wendell; Trentini, Michael

    2013-05-01

    A simple, quantitative measure for encapsulating the autonomous capabilities of unmanned systems (UMS) has yet to be established. Current models for measuring a UMS's autonomy level require extensive, operational level testing, and provide a means for assessing the autonomy level for a specific mission/task and operational environment. A more elegant technique for quantifying autonomy using component level testing of the robot platform alone, outside of mission and environment contexts, is desirable. Using a high level framework for UMS architectures, such a model for determining a level of autonomy has been developed. The model uses a combination of developmental and component level testing for each aspect of the UMS architecture to define a non-contextual autonomous potential (NCAP). The NCAP provides an autonomy level, ranging from fully non- autonomous to fully autonomous, in the form of a single numeric parameter describing the UMS's performance capabilities when operating at that level of autonomy.

  20. Modeling microbial products in activated sludge under feast-famine conditions.

    PubMed

    Ni, Bing-Jie; Fang, Fang; Rittmann, Bruce E; Yu, Han-Qing

    2009-04-01

    We develop an expanded unified model that integrates production and consumption of internal storage products (X(STO)) into a unified model for extracellular polymeric substances (EPS), soluble microbial products (SMP), and active and inert biomass in activated sludge. We also conducted independent experiments to find needed parameter values and to test the ability of the expanded unified model to describe all the microbial products, along with original substrate and oxygen uptake. The model simulations match all experimental measurements and provide insights into the dynamics of soluble and solid components in activated sludge exposed to dynamic feast-and-famine conditions in two batch experiments and in one cycle of a sequencing batch reactor. In particular, the model illustrates how X(STO) cycles up and down rapidly during feast and famine periods, while EPS and biomass components are relatively stable despite feast and famine. The agreement between model outputs and experimental EPS, SMP, and X(STO) data from distinctly different experiments supports that the expanded unified model properly captures the relationships among the forms of microbial products.

  1. Hard X-ray tests of the unified model for an ultraviolet-detected sample of Seyfert 2 galaxies

    NASA Technical Reports Server (NTRS)

    Mulchaey, John S.; Myshotzky, Richard F.; Weaver, Kimberly A.

    1992-01-01

    An ultraviolet-detected sample of Seyfert 2 galaxies shows heavy photoelectric absorption in the hard X-ray band. The presence of UV emission combined with hard X-ray absorption argues strongly for a special geometry which must have the general properties of the Antonucci and Miller unified model. The observations of this sample are consistent with the picture in which the hard X-ray photons are viewed directly through the obscuring matter (molecular torus?) and the optical, UV, and soft X-ray continuum are seen in scattered light. The large range in X-ray column densities implies that there must be a large variation in intrinsic thicknesses of molecular tori, an assumption not found in the simplest of unified models. Furthermore, constraints based on the cosmic X-ray background suggest that some of the underlying assumptions of the unified model are wrong.

  2. Evidence accumulation in decision making: unifying the "take the best" and the "rational" models.

    PubMed

    Lee, Michael D; Cummins, Tarrant D R

    2004-04-01

    An evidence accumulation model of forced-choice decision making is proposed to unify the fast and frugal take the best (TTB) model and the alternative rational (RAT) model with which it is usually contrasted. The basic idea is to treat the TTB model as a sequential-sampling process that terminates as soon as any evidence in favor of a decision is found and the rational approach as a sequential-sampling process that terminates only when all available information has been assessed. The unified TTB and RAT models were tested in an experiment in which participants learned to make correct judgments for a set of real-world stimuli on the basis of feedback, and were then asked to make additional judgments without feedback for cases in which the TTB and the rational models made different predictions. The results show that, in both experiments, there was strong intraparticipant consistency in the use of either the TTB or the rational model but large interparticipant differences in which model was used. The unified model is shown to be able to capture the differences in decision making across participants in an interpretable way and is preferred by the minimum description length model selection criterion.

  3. A model for calculating expected performance of the Apollo unified S-band (USB) communication system

    NASA Technical Reports Server (NTRS)

    Schroeder, N. W.

    1971-01-01

    A model for calculating the expected performance of the Apollo unified S-band (USB) communication system is presented. The general organization of the Apollo USB is described. The mathematical model is reviewed and the computer program for implementation of the calculations is included.

  4. Dynamic Cognitive Tracing: Towards Unified Discovery of Student and Cognitive Models

    ERIC Educational Resources Information Center

    Gonzalez-Brenes, Jose P.; Mostow, Jack

    2012-01-01

    This work describes a unified approach to two problems previously addressed separately in Intelligent Tutoring Systems: (i) Cognitive Modeling, which factorizes problem solving steps into the latent set of skills required to perform them; and (ii) Student Modeling, which infers students' learning by observing student performance. The practical…

  5. Nonlinear adaptive inverse control via the unified model neural network

    NASA Astrophysics Data System (ADS)

    Jeng, Jin-Tsong; Lee, Tsu-Tian

    1999-03-01

    In this paper, we propose a new nonlinear adaptive inverse control via a unified model neural network. In order to overcome nonsystematic design and long training time in nonlinear adaptive inverse control, we propose the approximate transformable technique to obtain a Chebyshev Polynomials Based Unified Model (CPBUM) neural network for the feedforward/recurrent neural networks. It turns out that the proposed method can use less training time to get an inverse model. Finally, we apply this proposed method to control magnetic bearing system. The experimental results show that the proposed nonlinear adaptive inverse control architecture provides a greater flexibility and better performance in controlling magnetic bearing systems.

  6. Unified phenology model with Bayesian calibration for several European species in Belgium

    NASA Astrophysics Data System (ADS)

    Fu, Y. S. H.; Demarée, G.; Hamdi, R.; Deckmyn, A.; Deckmyn, G.; Janssens, I. A.

    2009-04-01

    Plant phenology is a good bio-indicator for climate change, and this has brought a significant increase of interest. Many kinds of phenology models have been developed to analyze and predict the phenological response to climate change, and those models have been summarized into one kind of unified model, which could be applied to different species and environments. In our study, we selected seven European woody plant species (Betula verrucosa, Quercus robur pedunculata, Fagus sylvatica, Fraxinus excelsior, Symphoricarpus racemosus, Aesculus hippocastanum, Robinia pseudoacacia) occurring in five sites distributed across Belgium. For those sites and tree species, phenological observations such as bud burst were available for the period 1956 - 2002. We also obtained regional downscaled climatic data for each of these sites, and combined both data sets to test the unified model. We used a Bayesian approach to generate distributions of model parameters from the observation data. In this poster presentation, we compare parameter distributions between different species and between different sites for individual species. The results of the unified model show a good agreement with the observations, except for Fagus sylvatica. The failure to reproduce the bud burst data for Fagus sylvatica suggest that the other factors not included in the unified model affect the phenology of this species. The parameter series show differences among species as we expected. However, they also differed strongly for the same species among sites.Further work should elucidate the mechanism that explains why model parameters differ among species and sites.

  7. Incubation, Insight, and Creative Problem Solving: A Unified Theory and a Connectionist Model

    ERIC Educational Resources Information Center

    Helie, Sebastien; Sun, Ron

    2010-01-01

    This article proposes a unified framework for understanding creative problem solving, namely, the explicit-implicit interaction theory. This new theory of creative problem solving constitutes an attempt at providing a more unified explanation of relevant phenomena (in part by reinterpreting/integrating various fragmentary existing theories of…

  8. SAO and Kelvin Waves in the EuroGRIPS GCMS and the UK Meteorological Offices Analyses

    NASA Technical Reports Server (NTRS)

    Amodei, M.; Pawson, S.; Scaife, A. A.; Lahoz, W.; Langematz, U.; Li, Ding Min; Simon, P.

    2000-01-01

    This work is an intercomparison of four tropospheric-stratospheric climate models, the Unified Model (UM) of the U.K. Meteorological Office (UKMO), the model of the Free University in Berlin (FUB). the ARPEGE-climat model of the National Center for Meteorological Research (CNRM), and the Extended UGAMP GCM (EUGCM) of the Center for Global Atmospheric Modelling (CGAM), against the UKMO analyses. This comparison has been made in the framework of the "GSM-Reality Intercomparison Project for SPARC" (GRIPS). SPARC (Stratospheric Processes and their Role in Climate) aims are to investigate the effects of the middle atmosphere on climate and the GRIPS purpose is to organized a comprehensive assessment of current Middle Atmosphere-Climate Models (MACMs). The models integrations were made without identical contraints e.g. boundary conditions, incoming solar radiation). All models are able to represent the dominant features of the extratropical circulation. In this paper, the structure of the tropical winds and the strengths of the Kelvin waves are examined. Explanations for the differences exhibited. between the models. as well as between models and analyses, are also proposed. In the analyses a rich spectrum of waves (eastward and westward) is present and contributes to drive the SAO (SemiAnnual Oscillation) and the QBO (Quasi-Biennal Oscillation). The amplitude of the Kelvin waves is close to the one observed in UARS (Upper Atmosphere Research Satellite) data. In agreement with observations, the Kelvin waves generated in the models propagate into the middle atmosphere as wave packets which underlines convective forcing origin. In most models, slow Kelvin waves propagate too high and are hence overestimated in the upper stratosphere and in the mesosphere, except for the UM which is more diffusive. These waves are not sufficient to force realistic westerlies of the QBO or SAO westerly phases. If the SAO is represented by all models only two of them are able to generate westerlies between 10 hPa and 50 hPa. The importance of the role played by subgrided gravity waves is more and more recognized. Actually, the EUGCM which includes a parametrization of gravity waves with a non-zero phase speed is able to simulate. with however some unrealistic features, clear easterly to westerly transitions as well as westerlies downward propagations. Thermal damping is also important in the westerlies forcing in the stratosphere. The model ARPEGE-climat shows more westerlies in the stratosphere than tile other three models probably due to the use of a simplified scheme to predict the ozone distribution in the middle atmosphere.

  9. A Unified Framework for Complex Networks with Degree Trichotomy Based on Markov Chains.

    PubMed

    Hui, David Shui Wing; Chen, Yi-Chao; Zhang, Gong; Wu, Weijie; Chen, Guanrong; Lui, John C S; Li, Yingtao

    2017-06-16

    This paper establishes a Markov chain model as a unified framework for describing the evolution processes in complex networks. The unique feature of the proposed model is its capability in addressing the formation mechanism that can reflect the "trichotomy" observed in degree distributions, based on which closed-form solutions can be derived. Important special cases of the proposed unified framework are those classical models, including Poisson, Exponential, Power-law distributed networks. Both simulation and experimental results demonstrate a good match of the proposed model with real datasets, showing its superiority over the classical models. Implications of the model to various applications including citation analysis, online social networks, and vehicular networks design, are also discussed in the paper.

  10. Creating a library holding group: an approach to large system integration.

    PubMed

    Huffman, Isaac R; Martin, Heather J; Delawska-Elliott, Basia

    2016-10-01

    Faced with resource constraints, many hospital libraries have considered joint operations. This case study describes how Providence Health & Services created a single group to provide library services. Using a holding group model, staff worked to unify more than 6,100 nonlibrary subscriptions and 14 internal library sites. Our library services grew by unifying 2,138 nonlibrary subscriptions and 11 library sites and hiring more library staff. We expanded access to 26,018 more patrons. A model with built-in flexibility allowed successful library expansion. Although challenges remain, this success points to a viable model of unified operations.

  11. Developing and Validating Path-Dependent Uncertainty Estimates for use with the Regional Seismic Travel Time (RSTT) Model

    NASA Astrophysics Data System (ADS)

    Begnaud, M. L.; Anderson, D. N.; Phillips, W. S.; Myers, S. C.; Ballard, S.

    2016-12-01

    The Regional Seismic Travel Time (RSTT) tomography model has been developed to improve travel time predictions for regional phases (Pn, Sn, Pg, Lg) in order to increase seismic location accuracy, especially for explosion monitoring. The RSTT model is specifically designed to exploit regional phases for location, especially when combined with teleseismic arrivals. The latest RSTT model (version 201404um) has been released (http://www.sandia.gov/rstt). Travel time uncertainty estimates for RSTT are determined using one-dimensional (1D), distance-dependent error models, that have the benefit of being very fast to use in standard location algorithms, but do not account for path-dependent variations in error, and structural inadequacy of the RSTTT model (e.g., model error). Although global in extent, the RSTT tomography model is only defined in areas where data exist. A simple 1D error model does not accurately model areas where RSTT has not been calibrated. We are developing and validating a new error model for RSTT phase arrivals by mathematically deriving this multivariate model directly from a unified model of RSTT embedded into a statistical random effects model that captures distance, path and model error effects. An initial method developed is a two-dimensional path-distributed method using residuals. The goals for any RSTT uncertainty method are for it to be both readily useful for the standard RSTT user as well as improve travel time uncertainty estimates for location. We have successfully tested using the new error model for Pn phases and will demonstrate the method and validation of the error model for Sn, Pg, and Lg phases.

  12. Unified Model for Academic Competence, Social Adjustment, and Psychopathology.

    ERIC Educational Resources Information Center

    Schaefer, Earl S.; And Others

    A unified conceptual model is needed to integrate the extensive research on (1) social competence and adaptive behavior, (2) converging conceptualizations of social adjustment and psychopathology, and (3) emerging concepts and measures of academic competence. To develop such a model, a study was conducted in which teacher ratings were collected on…

  13. Met UM Upper-tropospheric summer jet teleconnections: A model assessment

    NASA Astrophysics Data System (ADS)

    Joao Carvalho, Maria; Rodriguez, Jose; Milton, Sean

    2017-04-01

    The upper tropospheric jet stream has been documented to act as a waveguide (Hoskins and Ambrizzi, 1993) and supporting quasi-stationary Rossby waves (Schubert et al. 2011). These have been associated with remote effects in surface level weather such as rainfall anomalies in the East Asian Summer Monsoon as well as extreme temperature events. The goal of this work was to analyse the intraseasonal to interannual upper level boreal summer jet variability and its coupling with low level atmospheric dynamics within the Met Office Unified Model using climate runs. Using the Wallace and Gutzler (1981) proposed approach to find teleconnection patterns on the 200 hPa level wind, lead-lag correlation and Empirical Orthogonal Function analysis on the upper-level jet and relating the results with surface weather variables as well as dynamical variables, it was found that the model presents too strong jet variability, particularly in the tropical region and. In addition, the model presents high teleconnectivity hotspots with higher importance in areas such as the Mediterranean and Caspian Sea which are important source areas for Rossby Waves. Further to this, the model was found to produce an area of teleconnectivity between the tropical Atlantic and western Africa which is not observed in the reanalysis but coexists with long lasting precipitation biases. As comparison for the model results, ERA-Interim circulation and wind data and the TRMM precipitation dataset were used. In order to assess the relative importance of relevant model parameters in the biases and process errors, work is currently underway using perturbed model parameter ensembles.

  14. Unified Science Approach K-12, Proficiency Levels 7-12.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented is the second part of the K-12 unified science materials used in the public schools of Anne Arundel County, Maryland. Detailed descriptions are made of the roles of students and teachers, purposes of the bibliography, major concepts in unified science, processes of inquiry, a scheme and model for scientific literacy, and program…

  15. Unified Science Approach K-12, Proficiency Levels 1-6.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented are first-revision materials of the K-12 unified science program implemented in the public schools of Anne Arundel County, Maryland. Detailed descriptions are given of the roles of students and teachers, purposes of bibliography, major concepts in unified science, processes of inquiry, scheme and model for scientific literacy, and…

  16. Collaborative Research: Reducing tropical precipitation biases in CESM — Tests of unified parameterizations with ARM observations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larson, Vincent; Gettelman, Andrew; Morrison, Hugh

    In state-of-the-art climate models, each cloud type is treated using its own separate cloud parameterization and its own separate microphysics parameterization. This use of separate schemes for separate cloud regimes is undesirable because it is theoretically unfounded, it hampers interpretation of results, and it leads to the temptation to overtune parameters. In this grant, we are creating a climate model that contains a unified cloud parameterization and a unified microphysics parameterization. This model will be used to address the problems of excessive frequency of drizzle in climate models and excessively early onset of deep convection in the Tropics over land.more » The resulting model will be compared with ARM observations.« less

  17. Sandia/Stanford Unified Creep Plasticity Damage Model for ANSYS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pierce, David M.; Vianco, Paul T.; Fossum, Arlo F.

    2006-09-03

    A unified creep plasticity (UCP) model was developed, based upon the time-dependent and time-independent deformation properties of the 95.5Sn-3.9Ag-0.6Cu (wt.%) soldier that were measured at Sandia. Then, a damage parameter, D, was added to the equation to develop the unified creep plasticity damage (UCPD) model. The parameter, D, was parameterized, using data obtained at Sandia from isothermal fatigue experiments on a double-lap shear test. The softwae was validated against a BGA solder joint exposed to thermal cycling. The UCPD model was put into the ANSYS finite element as a subroutine. So, the softwae is the subroutine for ANSYS 8.1.

  18. Using Machine Learning as a fast emulator of physical processes within the Met Office's Unified Model

    NASA Astrophysics Data System (ADS)

    Prudden, R.; Arribas, A.; Tomlinson, J.; Robinson, N.

    2017-12-01

    The Unified Model is a numerical model of the atmosphere used at the UK Met Office (and numerous partner organisations including Korean Meteorological Agency, Australian Bureau of Meteorology and US Air Force) for both weather and climate applications.Especifically, dynamical models such as the Unified Model are now a central part of weather forecasting. Starting from basic physical laws, these models make it possible to predict events such as storms before they have even begun to form. The Unified Model can be simply described as having two components: one component solves the navier-stokes equations (usually referred to as the "dynamics"); the other solves relevant sub-grid physical processes (usually referred to as the "physics"). Running weather forecasts requires substantial computing resources - for example, the UK Met Office operates the largest operational High Performance Computer in Europe - and the cost of a typical simulation is spent roughly 50% in the "dynamics" and 50% in the "physics". Therefore there is a high incentive to reduce cost of weather forecasts and Machine Learning is a possible option because, once a machine learning model has been trained, it is often much faster to run than a full simulation. This is the motivation for a technique called model emulation, the idea being to build a fast statistical model which closely approximates a far more expensive simulation. In this paper we discuss the use of Machine Learning as an emulator to replace the "physics" component of the Unified Model. Various approaches and options will be presented and the implications for further model development, operational running of forecasting systems, development of data assimilation schemes, and development of ensemble prediction techniques will be discussed.

  19. Unified Program Design: Organizing Existing Programming Models, Delivery Options, and Curriculum

    ERIC Educational Resources Information Center

    Rubenstein, Lisa DaVia; Ridgley, Lisa M.

    2017-01-01

    A persistent problem in the field of gifted education has been the lack of categorization and delineation of gifted programming options. To address this issue, we propose Unified Program Design as a structural framework for gifted program models. This framework defines gifted programs as the combination of delivery methods and curriculum models.…

  20. Unified Science Approach K-12, Proficiency Levels 13-21 and Semester Courses.

    ERIC Educational Resources Information Center

    Oickle, Eileen M., Ed.

    Presented is the third part of the K-12 unified science materials used in the public schools of Anne Arundel County, Maryland. Detailed descriptions are presented for the roles of students and teachers, purposes of bibliography, major concepts in unified science, processes of inquiry, scheme and model for scientific literacy, and program…

  1. Unified Approach to Modeling and Simulation of Space Communication Networks and Systems

    NASA Technical Reports Server (NTRS)

    Barritt, Brian; Bhasin, Kul; Eddy, Wesley; Matthews, Seth

    2010-01-01

    Network simulator software tools are often used to model the behaviors and interactions of applications, protocols, packets, and data links in terrestrial communication networks. Other software tools that model the physics, orbital dynamics, and RF characteristics of space systems have matured to allow for rapid, detailed analysis of space communication links. However, the absence of a unified toolset that integrates the two modeling approaches has encumbered the systems engineers tasked with the design, architecture, and analysis of complex space communication networks and systems. This paper presents the unified approach and describes the motivation, challenges, and our solution - the customization of the network simulator to integrate with astronautical analysis software tools for high-fidelity end-to-end simulation. Keywords space; communication; systems; networking; simulation; modeling; QualNet; STK; integration; space networks

  2. A Global 3D P-Velocity Model of the Earth’s Crust and Mantle for Improved Event Location

    DTIC Science & Technology

    2011-09-01

    starting model, we use a simplified layer crustal model derived from the NNSA Unified model in Eurasia and Crust 2.0 model everywhere else, over a...geographic and radial dimensions. For our starting model, we use a simplified layer crustal model derived from the NNSA Unified model in Eurasia and...tessellation with 4° triangles to the transition zone and upper mantle, and a third tessellation with variable resolution to all crustal layers. The

  3. Unified-theory-of-reinforcement neural networks do not simulate the blocking effect.

    PubMed

    Calvin, Nicholas T; J McDowell, J

    2015-11-01

    For the last 20 years the unified theory of reinforcement (Donahoe et al., 1993) has been used to develop computer simulations to evaluate its plausibility as an account for behavior. The unified theory of reinforcement states that operant and respondent learning occurs via the same neural mechanisms. As part of a larger project to evaluate the operant behavior predicted by the theory, this project was the first replication of neural network models based on the unified theory of reinforcement. In the process of replicating these neural network models it became apparent that a previously published finding, namely, that the networks simulate the blocking phenomenon (Donahoe et al., 1993), was a misinterpretation of the data. We show that the apparent blocking produced by these networks is an artifact of the inability of these networks to generate the same conditioned response to multiple stimuli. The piecemeal approach to evaluate the unified theory of reinforcement via simulation is critiqued and alternatives are discussed. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Microphysics in Multi-scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2012-01-01

    Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (1) a cloud-resolving model (Goddard Cumulus Ensemble model, GCE model), (2) a regional scale model (a NASA unified weather research and forecast, WRF), (3) a coupled CRM and global model (Goddard Multi-scale Modeling Framework, MMF), and (4) a land modeling system. The same microphysical processes, long and short wave radiative transfer and land processes and the explicit cloud-radiation, and cloud-land surface interactive processes are applied in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator to use NASA high-resolution satellite data to identify the strengths and weaknesses of cloud and precipitation processes simulated by the model. In this talk, a review of developments and applications of the multi-scale modeling system will be presented. In particular, the microphysics development and its performance for the multi-scale modeling system will be presented.

  5. Human-model hybrid Korean air quality forecasting system.

    PubMed

    Chang, Lim-Seok; Cho, Ara; Park, Hyunju; Nam, Kipyo; Kim, Deokrae; Hong, Ji-Hyoung; Song, Chang-Keun

    2016-09-01

    The Korean national air quality forecasting system, consisting of the Weather Research and Forecasting, the Sparse Matrix Operator Kernel Emissions, and the Community Modeling and Analysis (CMAQ), commenced from August 31, 2013 with target pollutants of particulate matters (PM) and ozone. Factors contributing to PM forecasting accuracy include CMAQ inputs of meteorological field and emissions, forecasters' capacity, and inherent CMAQ limit. Four numerical experiments were conducted including two global meteorological inputs from the Global Forecast System (GFS) and the Unified Model (UM), two emissions from the Model Intercomparison Study Asia (MICS-Asia) and the Intercontinental Chemical Transport Experiment (INTEX-B) for the Northeast Asia with Clear Air Policy Support System (CAPSS) for South Korea, and data assimilation of the Monitoring Atmospheric Composition and Climate (MACC). Significant PM underpredictions by using both emissions were found for PM mass and major components (sulfate and organic carbon). CMAQ predicts PM2.5 much better than PM10 (NMB of PM2.5: -20~-25%, PM10: -43~-47%). Forecasters' error usually occurred at the next day of high PM event. Once CMAQ fails to predict high PM event the day before, forecasters are likely to dismiss the model predictions on the next day which turns out to be true. The best combination of CMAQ inputs is the set of UM global meteorological field, MICS-Asia and CAPSS 2010 emissions with the NMB of -12.3%, the RMSE of 16.6μ/m(3) and the R(2) of 0.68. By using MACC data as an initial and boundary condition, the performance skill of CMAQ would be improved, especially in the case of undefined coarse emission. A variety of methods such as ensemble and data assimilation are considered to improve further the accuracy of air quality forecasting, especially for high PM events to be comparable to for all cases. The growing utilization of the air quality forecast induced the public strongly to demand that the accuracy of the national forecasting be improved. In this study, we investigated the problems in the current forecasting as well as various alternatives to solve the problems. Such efforts to improve the accuracy of the forecast are expected to contribute to the protection of public health by increasing the availability of the forecast system.

  6. Phase noise suppression for coherent optical block transmission systems: a unified framework.

    PubMed

    Yang, Chuanchuan; Yang, Feng; Wang, Ziyu

    2011-08-29

    A unified framework for phase noise suppression is proposed in this paper, which could be applied in any coherent optical block transmission systems, including coherent optical orthogonal frequency-division multiplexing (CO-OFDM), coherent optical single-carrier frequency-domain equalization block transmission (CO-SCFDE), etc. Based on adaptive modeling of phase noise, unified observation equations for different coherent optical block transmission systems are constructed, which lead to unified phase noise estimation and suppression. Numerical results demonstrate that the proposal is powerful in mitigating laser phase noise.

  7. A Unified Model Exploring Parenting Practices as Mediators of Marital Conflict and Children's Adjustment

    ERIC Educational Resources Information Center

    Coln, Kristen L.; Jordan, Sara S.; Mercer, Sterett H.

    2013-01-01

    We examined positive and negative parenting practices and psychological control as mediators of the relations between constructive and destructive marital conflict and children's internalizing and externalizing problems in a unified model. Married mothers of 121 children between the ages of 6 and 12 completed questionnaires measuring marital…

  8. Can (should) theories of crowding be unified?

    PubMed Central

    Agaoglu, Mehmet N.; Chung, Susana T. L.

    2016-01-01

    Objects in clutter are difficult to recognize, a phenomenon known as crowding. There is little consensus on the underlying mechanisms of crowding, and a large number of models have been proposed. There have also been attempts at unifying the explanations of crowding under a single model, such as the weighted feature model of Harrison and Bex (2015) and the texture synthesis model of Rosenholtz and colleagues (Balas, Nakano, & Rosenholtz, 2009; Keshvari & Rosenholtz, 2016). The goal of this work was to test various models of crowding and to assess whether a unifying account can be developed. Adopting Harrison and Bex's (2015) experimental paradigm, we asked observers to report the orientation of two concentric C-stimuli. Contrary to the predictions of their model, observers' recognition accuracy was worse for the inner C-stimulus. In addition, we demonstrated that the stimulus paradigm used by Harrison and Bex has a crucial confounding factor, eccentricity, which limits its usage to a very narrow range of stimulus parameters. Nevertheless, reporting the orientations of both C-stimuli in this paradigm proved very useful in pitting different crowding models against each other. Specifically, we tested deterministic and probabilistic versions of averaging, substitution, and attentional resolution models as well as the texture synthesis model. None of the models alone was able to explain the entire set of data. Based on these findings, we discuss whether the explanations of crowding can (should) be unified. PMID:27936273

  9. An OpenACC-Based Unified Programming Model for Multi-accelerator Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Jungwon; Lee, Seyong; Vetter, Jeffrey S

    2015-01-01

    This paper proposes a novel SPMD programming model of OpenACC. Our model integrates the different granularities of parallelism from vector-level parallelism to node-level parallelism into a single, unified model based on OpenACC. It allows programmers to write programs for multiple accelerators using a uniform programming model whether they are in shared or distributed memory systems. We implement a prototype of our model and evaluate its performance with a GPU-based supercomputer using three benchmark applications.

  10. On the reachable cycles via the unified perspective of cryocoolers. Part B: Cryocoolers with isentropic expanders

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maytal, Ben-Zion; Pfotenhauer, John M.

    2014-01-29

    Solvay, Stirling and Gifford-McMahon types of cryocoolers employ an isentropic expander which is their elementary mechanism for temperature reduction (following the unified model of cryocoolers as described in a previous paper, Part A). Solvay and Stirling cryocoolers are driven by a larger temperature reduction than that of the Gifford-McMahon cycle, for a similar compression ratio. These cryocoolers are compared from the view of the unified model, in terms of the lowest attainable temperature, compression ratio, the size of the interchanger and the applied heat load.

  11. Unified viscoelasticity: Applying discrete element models to soft tissues with two characteristic times.

    PubMed

    Anssari-Benam, Afshin; Bucchi, Andrea; Bader, Dan L

    2015-09-18

    Discrete element models have often been the primary tool in investigating and characterising the viscoelastic behaviour of soft tissues. However, studies have employed varied configurations of these models, based on the choice of the number of elements and the utilised formation, for different subject tissues. This approach has yielded a diverse array of viscoelastic models in the literature, each seemingly resulting in different descriptions of viscoelastic constitutive behaviour and/or stress-relaxation and creep functions. Moreover, most studies do not apply a single discrete element model to characterise both stress-relaxation and creep behaviours of tissues. The underlying assumption for this disparity is the implicit perception that the viscoelasticity of soft tissues cannot be described by a universal behaviour or law, resulting in the lack of a unified approach in the literature based on discrete element representations. This paper derives the constitutive equation for different viscoelastic models applicable to soft tissues with two characteristic times. It demonstrates that all possible configurations exhibit a unified and universal behaviour, captured by a single constitutive relationship between stress, strain and time as: σ+Aσ̇+Bσ¨=Pε̇+Qε¨. The ensuing stress-relaxation G(t) and creep J(t) functions are also unified and universal, derived as [Formula: see text] and J(t)=c2+(ε0-c2)e(-PQt)+σ0Pt, respectively. Application of these relationships to experimental data is illustrated for various tissues including the aortic valve, ligament and cerebral artery. The unified model presented in this paper may be applied to all tissues with two characteristic times, obviating the need for employing varied configurations of discrete element models in preliminary investigation of the viscoelastic behaviour of soft tissues. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Control of Distributed Parameter Systems

    DTIC Science & Technology

    1990-08-01

    vari- ant of the general Lotka - Volterra model for interspecific competition. The variant described the emergence of one subpopulation from another as a...distribut ion unlimited. I&. ARSTRACT (MAUMUnw2O1 A unified arioroximation framework for Parameter estimation In general linear POE models has been completed...unified approximation framework for parameter estimation in general linear PDE models. This framework has provided the theoretical basis for a number of

  13. A unified computational model of the development of object unity, object permanence, and occluded object trajectory perception.

    PubMed

    Franz, A; Triesch, J

    2010-12-01

    The perception of the unity of objects, their permanence when out of sight, and the ability to perceive continuous object trajectories even during occlusion belong to the first and most important capacities that infants have to acquire. Despite much research a unified model of the development of these abilities is still missing. Here we make an attempt to provide such a unified model. We present a recurrent artificial neural network that learns to predict the motion of stimuli occluding each other and that develops representations of occluded object parts. It represents completely occluded, moving objects for several time steps and successfully predicts their reappearance after occlusion. This framework allows us to account for a broad range of experimental data. Specifically, the model explains how the perception of object unity develops, the role of the width of the occluders, and it also accounts for differences between data for moving and stationary stimuli. We demonstrate that these abilities can be acquired by learning to predict the sensory input. The model makes specific predictions and provides a unifying framework that has the potential to be extended to other visual event categories. Copyright © 2010 Elsevier Inc. All rights reserved.

  14. Coupled hydro-meteorological modelling on a HPC platform for high-resolution extreme weather impact study

    NASA Astrophysics Data System (ADS)

    Zhu, Dehua; Echendu, Shirley; Xuan, Yunqing; Webster, Mike; Cluckie, Ian

    2016-11-01

    Impact-focused studies of extreme weather require coupling of accurate simulations of weather and climate systems and impact-measuring hydrological models which themselves demand larger computer resources. In this paper, we present a preliminary analysis of a high-performance computing (HPC)-based hydrological modelling approach, which is aimed at utilizing and maximizing HPC power resources, to support the study on extreme weather impact due to climate change. Here, four case studies are presented through implementation on the HPC Wales platform of the UK mesoscale meteorological Unified Model (UM) with high-resolution simulation suite UKV, alongside a Linux-based hydrological model, Hydrological Predictions for the Environment (HYPE). The results of this study suggest that the coupled hydro-meteorological model was still able to capture the major flood peaks, compared with the conventional gauge- or radar-driving forecast, but with the added value of much extended forecast lead time. The high-resolution rainfall estimation produced by the UKV performs similarly to that of radar rainfall products in the first 2-3 days of tested flood events, but the uncertainties particularly increased as the forecast horizon goes beyond 3 days. This study takes a step forward to identify how the online mode approach can be used, where both numerical weather prediction and the hydrological model are executed, either simultaneously or on the same hardware infrastructures, so that more effective interaction and communication can be achieved and maintained between the models. But the concluding comments are that running the entire system on a reasonably powerful HPC platform does not yet allow for real-time simulations, even without the most complex and demanding data simulation part.

  15. Interstellar and Solar System Organic Matter Preserved in Interplanetary Dust

    NASA Technical Reports Server (NTRS)

    Messenger, Scott; Nakamura-Messenger, Keiko

    2015-01-01

    Interplanetary dust particles (IDPs) collected in the Earth's stratosphere derive from collisions among asteroids and by the disruption and outgassing of short-period comets. Chondritic porous (CP) IDPs are among the most primitive Solar System materials. CP-IDPs have been linked to cometary parent bodies by their mineralogy, textures, C-content, and dynamical histories. CP-IDPs are fragile, fine-grained (less than um) assemblages of anhydrous amorphous and crystalline silicates, oxides and sulfides bound together by abundant carbonaceous material. Ancient silicate, oxide, and SiC stardust grains exhibiting highly anomalous isotopic compositions are abundant in CP-IDPs, constituting 0.01 - 1 % of the mass of the particles. The organic matter in CP-IDPs is isotopically anomalous, with enrichments in D/H reaching 50x the terrestrial SMOW value and 15N/14N ratios up to 3x terrestrial standard compositions. These anomalies are indicative of low T (10-100 K) mass fractionation in cold molecular cloud or the outermost reaches of the protosolar disk. The organic matter shows distinct morphologies, including sub-um globules, bubbly textures, featureless, and with mineral inclusions. Infrared spectroscopy and mass spectrometry studies of organic matter in IDPs reveals diverse species including aliphatic and aromatic compounds. The organic matter with the highest isotopic anomalies appears to be richer in aliphatic compounds. These materials also bear similarities and differences with primitive, isotopically anomalous organic matter in carbonaceous chondrite meteorites. The diversity of the organic chemistry, morphology, and isotopic properties in IDPs and meteorites reflects variable preservation of interstellar/primordial components and Solar System processing. One unifying feature is the presence of sub-um isotopically anomalous organic globules among all primitive materials, including IDPs, meteorites, and comet Wild-2 samples returned by the Stardust mission.

  16. PIM Pedagogy: Toward a Loosely Unified Model for Teaching and Studying Comics and Graphic Novels

    ERIC Educational Resources Information Center

    Carter, James B.

    2015-01-01

    The article debuts and explains "PIM" pedagogy, a construct for teaching comics at the secondary- and post-secondary levels and for deep reading/studying comics. The PIM model for considering comics is actually based in major precepts of education studies, namely constructivist foundations of learning, and loosely unifies constructs…

  17. Integration Defended: Berkeley Unified's Strategy to Maintain School Diversity

    ERIC Educational Resources Information Center

    Chavez, Lisa; Frankenberg, Erica

    2009-01-01

    In June 2007, the Supreme Court limited the tools that school districts could use to voluntarily integrate schools. In the aftermath of the decision, educators around the country have sought models of successful plans that would also be legal. One such model may be Berkeley Unified School District's (BUSD) plan. Earlier this year, the California…

  18. Theoretical Foundation of Copernicus: A Unified System for Trajectory Design and Optimization

    NASA Technical Reports Server (NTRS)

    Ocampo, Cesar; Senent, Juan S.; Williams, Jacob

    2010-01-01

    The fundamental methods are described for the general spacecraft trajectory design and optimization software system called Copernicus. The methods rely on a unified framework that is used to model, design, and optimize spacecraft trajectories that may operate in complex gravitational force fields, use multiple propulsion systems, and involve multiple spacecraft. The trajectory model, with its associated equations of motion and maneuver models, are discussed.

  19. Electron heating in a Monte Carlo model of a high Mach number, supercritical, collisionless shock

    NASA Technical Reports Server (NTRS)

    Ellison, Donald C.; Jones, Frank C.

    1987-01-01

    Preliminary work in the investigation of electron injection and acceleration at parallel shocks is presented. A simple model of electron heating that is derived from a unified shock model which includes the effects of an electrostatic potential jump is described. The unified shock model provides a kinetic description of the injection and acceleration of ions and a fluid description of electron heating at high Mach number, supercritical, and parallel shocks.

  20. User Modeling in Adaptive Hypermedia Educational Systems

    ERIC Educational Resources Information Center

    Martins, Antonio Constantino; Faria, Luiz; Vaz de Carvalho, Carlos; Carrapatoso, Eurico

    2008-01-01

    This document is a survey in the research area of User Modeling (UM) for the specific field of Adaptive Learning. The aims of this document are: To define what it is a User Model; To present existing and well known User Models; To analyze the existent standards related with UM; To compare existing systems. In the scientific area of User Modeling…

  1. Models and methods in delay discounting.

    PubMed

    Tesch, Aaron D; Sanfey, Alan G

    2008-04-01

    Delay discounting (DD) is a term typically used to describe the devaluation of rewards over time, and much research across a wide variety of domains has illustrated that people in general prefer a smaller reward delivered soon as opposed to a larger reward delivered at a later stage. Despite numerous attempts, a single unified model of DD that accounts for the varied pattern of results typically observed has been elusive. One of the difficulties in deriving a unified model is the presence of many framing and context effects, situations in which changing, apparently irrelevant, aspects of the choice scenarios lead to different selections. Additionally, different paradigms of DD research use quite different methodology, which poses challenges for a unified model. This chapter describes some of the difficulties in creating a single DD model and suggests some experiments that would help integrate different paradigms to create a clearer picture of DD.

  2. Unified constitutive material models for nonlinear finite-element structural analysis. [gas turbine engine blades and vanes

    NASA Technical Reports Server (NTRS)

    Kaufman, A.; Laflen, J. H.; Lindholm, U. S.

    1985-01-01

    Unified constitutive material models were developed for structural analyses of aircraft gas turbine engine components with particular application to isotropic materials used for high-pressure stage turbine blades and vanes. Forms or combinations of models independently proposed by Bodner and Walker were considered. These theories combine time-dependent and time-independent aspects of inelasticity into a continuous spectrum of behavior. This is in sharp contrast to previous classical approaches that partition inelastic strain into uncoupled plastic and creep components. Predicted stress-strain responses from these models were evaluated against monotonic and cyclic test results for uniaxial specimens of two cast nickel-base alloys, B1900+Hf and Rene' 80. Previously obtained tension-torsion test results for Hastelloy X alloy were used to evaluate multiaxial stress-strain cycle predictions. The unified models, as well as appropriate algorithms for integrating the constitutive equations, were implemented in finite-element computer codes.

  3. Two-stage unified stretched-exponential model for time-dependence of threshold voltage shift under positive-bias-stresses in amorphous indium-gallium-zinc oxide thin-film transistors

    NASA Astrophysics Data System (ADS)

    Jeong, Chan-Yong; Kim, Hee-Joong; Hong, Sae-Young; Song, Sang-Hun; Kwon, Hyuck-In

    2017-08-01

    In this study, we show that the two-stage unified stretched-exponential model can more exactly describe the time-dependence of threshold voltage shift (ΔV TH) under long-term positive-bias-stresses compared to the traditional stretched-exponential model in amorphous indium-gallium-zinc oxide (a-IGZO) thin-film transistors (TFTs). ΔV TH is mainly dominated by electron trapping at short stress times, and the contribution of trap state generation becomes significant with an increase in the stress time. The two-stage unified stretched-exponential model can provide useful information not only for evaluating the long-term electrical stability and lifetime of the a-IGZO TFT but also for understanding the stress-induced degradation mechanism in a-IGZO TFTs.

  4. A Unified Mathematical Definition of Classical Information Retrieval.

    ERIC Educational Resources Information Center

    Dominich, Sandor

    2000-01-01

    Presents a unified mathematical definition for the classical models of information retrieval and identifies a mathematical structure behind relevance feedback. Highlights include vector information retrieval; probabilistic information retrieval; and similarity information retrieval. (Contains 118 references.) (Author/LRW)

  5. Parametric models to relate spike train and LFP dynamics with neural information processing.

    PubMed

    Banerjee, Arpan; Dean, Heather L; Pesaran, Bijan

    2012-01-01

    Spike trains and local field potentials (LFPs) resulting from extracellular current flows provide a substrate for neural information processing. Understanding the neural code from simultaneous spike-field recordings and subsequent decoding of information processing events will have widespread applications. One way to demonstrate an understanding of the neural code, with particular advantages for the development of applications, is to formulate a parametric statistical model of neural activity and its covariates. Here, we propose a set of parametric spike-field models (unified models) that can be used with existing decoding algorithms to reveal the timing of task or stimulus specific processing. Our proposed unified modeling framework captures the effects of two important features of information processing: time-varying stimulus-driven inputs and ongoing background activity that occurs even in the absence of environmental inputs. We have applied this framework for decoding neural latencies in simulated and experimentally recorded spike-field sessions obtained from the lateral intraparietal area (LIP) of awake, behaving monkeys performing cued look-and-reach movements to spatial targets. Using both simulated and experimental data, we find that estimates of trial-by-trial parameters are not significantly affected by the presence of ongoing background activity. However, including background activity in the unified model improves goodness of fit for predicting individual spiking events. Uncovering the relationship between the model parameters and the timing of movements offers new ways to test hypotheses about the relationship between neural activity and behavior. We obtained significant spike-field onset time correlations from single trials using a previously published data set where significantly strong correlation was only obtained through trial averaging. We also found that unified models extracted a stronger relationship between neural response latency and trial-by-trial behavioral performance than existing models of neural information processing. Our results highlight the utility of the unified modeling framework for characterizing spike-LFP recordings obtained during behavioral performance.

  6. A unified model of the hierarchical and stochastic theories of gastric cancer

    PubMed Central

    Song, Yanjing; Wang, Yao; Tong, Chuan; Xi, Hongqing; Zhao, Xudong; Wang, Yi; Chen, Lin

    2017-01-01

    Gastric cancer (GC) is a life-threatening disease worldwide. Despite remarkable advances in treatments for GC, it is still fatal to many patients due to cancer progression, recurrence and metastasis. Regarding the development of novel therapeutic techniques, many studies have focused on the biological mechanisms that initiate tumours and cause treatment resistance. Tumours have traditionally been considered to result from somatic mutations, either via clonal evolution or through a stochastic model. However, emerging evidence has characterised tumours using a hierarchical organisational structure, with cancer stem cells (CSCs) at the apex. Both stochastic and hierarchical models are reasonable systems that have been hypothesised to describe tumour heterogeneity. Although each model alone inadequately explains tumour diversity, the two models can be integrated to provide a more comprehensive explanation. In this review, we discuss existing evidence supporting a unified model of gastric CSCs, including the regulatory mechanisms of this unified model in addition to the current status of stemness-related targeted therapy in GC patients. PMID:28301871

  7. A Novel Grid SINS/DVL Integrated Navigation Algorithm for Marine Application

    PubMed Central

    Kang, Yingyao; Zhao, Lin; Cheng, Jianhua; Fan, Xiaoliang

    2018-01-01

    Integrated navigation algorithms under the grid frame have been proposed based on the Kalman filter (KF) to solve the problem of navigation in some special regions. However, in the existing study of grid strapdown inertial navigation system (SINS)/Doppler velocity log (DVL) integrated navigation algorithms, the Earth models of the filter dynamic model and the SINS mechanization are not unified. Besides, traditional integrated systems with the KF based correction scheme are susceptible to measurement errors, which would decrease the accuracy and robustness of the system. In this paper, an adaptive robust Kalman filter (ARKF) based hybrid-correction grid SINS/DVL integrated navigation algorithm is designed with the unified reference ellipsoid Earth model to improve the navigation accuracy in middle-high latitude regions for marine application. Firstly, to unify the Earth models, the mechanization of grid SINS is introduced and the error equations are derived based on the same reference ellipsoid Earth model. Then, a more accurate grid SINS/DVL filter model is designed according to the new error equations. Finally, a hybrid-correction scheme based on the ARKF is proposed to resist the effect of measurement errors. Simulation and experiment results show that, compared with the traditional algorithms, the proposed navigation algorithm can effectively improve the navigation performance in middle-high latitude regions by the unified Earth models and the ARKF based hybrid-correction scheme. PMID:29373549

  8. New Model of Mobile Learning for the High School Students Preparing for the Unified State Exam

    ERIC Educational Resources Information Center

    Khasianov, Airat; Shakhova, Irina

    2017-01-01

    In this paper we study a new model of mobile learning for the Unified State Exam ("USE") preparation in Russian Federation. "USE"--is the test school graduates need to pass in order to obtain Russian matura. In recent years the efforts teachers put for preparation of their students to the "USE" diminish how well the…

  9. What Does CALL Have to Offer Computer Science and What Does Computer Science Have to Offer CALL?

    ERIC Educational Resources Information Center

    Cushion, Steve

    2006-01-01

    We will argue that CALL can usefully be viewed as a subset of computer software engineering and can profit from adopting some of the recent progress in software development theory. The unified modelling language has become the industry standard modelling technique and the accompanying unified process is rapidly gaining acceptance. The manner in…

  10. A unified structural/terminological interoperability framework based on LexEVS: application to TRANSFoRm.

    PubMed

    Ethier, Jean-François; Dameron, Olivier; Curcin, Vasa; McGilchrist, Mark M; Verheij, Robert A; Arvanitis, Theodoros N; Taweel, Adel; Delaney, Brendan C; Burgun, Anita

    2013-01-01

    Biomedical research increasingly relies on the integration of information from multiple heterogeneous data sources. Despite the fact that structural and terminological aspects of interoperability are interdependent and rely on a common set of requirements, current efforts typically address them in isolation. We propose a unified ontology-based knowledge framework to facilitate interoperability between heterogeneous sources, and investigate if using the LexEVS terminology server is a viable implementation method. We developed a framework based on an ontology, the general information model (GIM), to unify structural models and terminologies, together with relevant mapping sets. This allowed a uniform access to these resources within LexEVS to facilitate interoperability by various components and data sources from implementing architectures. Our unified framework has been tested in the context of the EU Framework Program 7 TRANSFoRm project, where it was used to achieve data integration in a retrospective diabetes cohort study. The GIM was successfully instantiated in TRANSFoRm as the clinical data integration model, and necessary mappings were created to support effective information retrieval for software tools in the project. We present a novel, unifying approach to address interoperability challenges in heterogeneous data sources, by representing structural and semantic models in one framework. Systems using this architecture can rely solely on the GIM that abstracts over both the structure and coding. Information models, terminologies and mappings are all stored in LexEVS and can be accessed in a uniform manner (implementing the HL7 CTS2 service functional model). The system is flexible and should reduce the effort needed from data sources personnel for implementing and managing the integration.

  11. A unified structural/terminological interoperability framework based on LexEVS: application to TRANSFoRm

    PubMed Central

    Ethier, Jean-François; Dameron, Olivier; Curcin, Vasa; McGilchrist, Mark M; Verheij, Robert A; Arvanitis, Theodoros N; Taweel, Adel; Delaney, Brendan C; Burgun, Anita

    2013-01-01

    Objective Biomedical research increasingly relies on the integration of information from multiple heterogeneous data sources. Despite the fact that structural and terminological aspects of interoperability are interdependent and rely on a common set of requirements, current efforts typically address them in isolation. We propose a unified ontology-based knowledge framework to facilitate interoperability between heterogeneous sources, and investigate if using the LexEVS terminology server is a viable implementation method. Materials and methods We developed a framework based on an ontology, the general information model (GIM), to unify structural models and terminologies, together with relevant mapping sets. This allowed a uniform access to these resources within LexEVS to facilitate interoperability by various components and data sources from implementing architectures. Results Our unified framework has been tested in the context of the EU Framework Program 7 TRANSFoRm project, where it was used to achieve data integration in a retrospective diabetes cohort study. The GIM was successfully instantiated in TRANSFoRm as the clinical data integration model, and necessary mappings were created to support effective information retrieval for software tools in the project. Conclusions We present a novel, unifying approach to address interoperability challenges in heterogeneous data sources, by representing structural and semantic models in one framework. Systems using this architecture can rely solely on the GIM that abstracts over both the structure and coding. Information models, terminologies and mappings are all stored in LexEVS and can be accessed in a uniform manner (implementing the HL7 CTS2 service functional model). The system is flexible and should reduce the effort needed from data sources personnel for implementing and managing the integration. PMID:23571850

  12. A unified parameterization of clouds and turbulence using CLUBB and subcolumns in the Community Atmosphere Model

    DOE PAGES

    Thayer-Calder, K.; Gettelman, A.; Craig, C.; ...

    2015-06-30

    Most global climate models parameterize separate cloud types using separate parameterizations. This approach has several disadvantages, including obscure interactions between parameterizations and inaccurate triggering of cumulus parameterizations. Alternatively, a unified cloud parameterization uses one equation set to represent all cloud types. Such cloud types include stratiform liquid and ice cloud, shallow convective cloud, and deep convective cloud. Vital to the success of a unified parameterization is a general interface between clouds and microphysics. One such interface involves drawing Monte Carlo samples of subgrid variability of temperature, water vapor, cloud liquid, and cloud ice, and feeding the sample points into amore » microphysics scheme.This study evaluates a unified cloud parameterization and a Monte Carlo microphysics interface that has been implemented in the Community Atmosphere Model (CAM) version 5.3. Results describing the mean climate and tropical variability from global simulations are presented. The new model shows a degradation in precipitation skill but improvements in short-wave cloud forcing, liquid water path, long-wave cloud forcing, precipitable water, and tropical wave simulation. Also presented are estimations of computational expense and investigation of sensitivity to number of subcolumns.« less

  13. A unified parameterization of clouds and turbulence using CLUBB and subcolumns in the Community Atmosphere Model

    DOE PAGES

    Thayer-Calder, Katherine; Gettelman, A.; Craig, Cheryl; ...

    2015-12-01

    Most global climate models parameterize separate cloud types using separate parameterizations.This approach has several disadvantages, including obscure interactions between parameterizations and inaccurate triggering of cumulus parameterizations. Alternatively, a unified cloud parameterization uses one equation set to represent all cloud types. Such cloud types include stratiform liquid and ice cloud, shallow convective cloud, and deep convective cloud. Vital to the success of a unified parameterization is a general interface between clouds and microphysics. One such interface involves drawing Monte Carlo samples of subgrid variability of temperature, water vapor, cloud liquid, and cloud ice, and feeding the sample points into a microphysicsmore » scheme. This study evaluates a unified cloud parameterization and a Monte Carlo microphysics interface that has been implemented in the Community Atmosphere Model (CAM) version 5.3. Results describing the mean climate and tropical variability from global simulations are presented. In conclusion, the new model shows a degradation in precipitation skill but improvements in short-wave cloud forcing, liquid water path, long-wave cloud forcing, perceptible water, and tropical wave simulation. Also presented are estimations of computational expense and investigation of sensitivity to number of subcolumns.« less

  14. A Unified Geodetic Vertical Velocity Field (UGVVF), Version 1.0

    NASA Astrophysics Data System (ADS)

    Schmalzle, G.; Wdowinski, S.

    2014-12-01

    Tectonic motion, volcanic inflation or deflation, as well as oil, gas and water pumping can induce vertical motion. In southern California these signals are inter-mingled. In tectonics, properly identifying regions that are contaminated by other signals can be important when estimating fault slip rates. Until recently vertical deformation rates determined by high precision Global Positioning Systems (GPS) had large uncertainties compared to horizontal components and were rarely used to constrain tectonic models of fault motion. However, many continuously occupied GPS stations have been operating for ten or more years, often delivering uncertainties of ~1 mm/yr or less, providing better constraints for tectonic modeling. Various processing centers produced GPS time series and estimated vertical velocity fields, each with their own set of processing techniques and assumptions. We compare vertical velocity solutions estimated by seven data processing groups as well as two combined solutions (Figure 1). These groups include: Central Washington University (CWU) and New Mexico Institute of Technology (NMT), and their combined solution provided by the Plate Boundary Observatory (PBO) through the UNAVCO website. Also compared are the Jet Propulsion Laboratory (JPL) and Scripps Orbit and Permanent Array Center (SOPAC) and their combined solution provided as part of the NASA MEaSUREs project. Smaller velocity fields included are from Amos et al., 2014, processed at the Nevada Geodetic Laboratory, Shen et al., 2011, processed by UCLA and called the Crustal Motion Map 4.0 (CMM4) dataset, and a new velocity field provided by the University of Miami (UM). Our analysis includes estimating and correcting for systematic vertical velocity and uncertainty differences between groups. Our final product is a unified velocity field that contains the median values of the adjusted velocity fields and their uncertainties. This product will be periodically updated when new velocity fields become available. A database and scripts to access the database will be available through the University of Miami (http://www.geodesy.miami.edu) website. Figure 1. Vertical velocity comparisons between processing groups (blue dots). Red line indicates equal velocities. Weighted Root Mean Square (WRMS) is shown.

  15. Global Modelling of the total OH reactivity: validation against measurements and atmospheric implications of the 'missing' sink

    NASA Astrophysics Data System (ADS)

    Ferracci, Valerio; Archibald, Alexander T.; Pyle, John A.

    2017-04-01

    The removal of most trace gases emitted into the atmosphere is primarily initiated by reaction with the hydroxyl radical, OH. A number of field campaigns over the last two decades have observed the presence of a "missing" sink of the OH radical in a variety of regions across the planet, from urban areas to remote forests: comparison of the direct measurements of the OH loss rate, also known as total OH reactivity, with the sum of individual known OH sinks (obtained via the simultaneous detection of species such as volatile organic compounds and nitrogen oxides) indicated that, in some cases, up to 80% of the total OH loss rate was unaccounted for. The implications of this finding are significant, as a potentially major OH sink operating in the atmosphere is not currently accounted for in atmospheric models: the presence of an additional OH sink might, for instance, lead to an increase in the atmospheric lifetime of a number of trace species, including high-impact greenhouse gases such as methane. The only modelling of the total OH reactivity is currently performed on a regional scale; a thorough assessment of the impact of the missing sink on the chemistry and climate of the planet by global modelling is therefore highly desirable. In this work a chemistry-climate model (the Met Office's Unified Model with the United Kingdom Chemistry and Aerosols scheme, UM-UKCA) was used to calculate the total OH reactivity at the planetary boundary layer. The model output was validated against available field measurements to verify that the known OH sinks observed in the field were reproduced correctly by the model: a good agreement was found between the data from more than 30 field campaigns and the model output. Following this, the effects of introducing novel OH sinks in the chemistry scheme were investigated. The first step was the introduction in the model of the newly characterised reactions of peroxy radicals (RO2) with OH, the kinetics and products of which have only recently been studied in the laboratory. Results from the UM-UKCA model show that reaction with RO2 might represent a non-negligible OH sink in remote environments, but cannot reconcile field measurements of the total OH reactivity with the sum of the individual sinks. To address this, an unspecified additional sink was added to the model in a series of simulations reproducing different scenarios (e.g., different OH recycling probabilities through the oxidation of the additional sink) with a view to establishing the impact of the additional OH sink on the oxidative capacity of the lower atmosphere.

  16. Unified Models of Turbulence and Nonlinear Wave Evolution in the Extended Solar Corona and Solar Wind

    NASA Technical Reports Server (NTRS)

    Wagner, William (Technical Monitor); Cranmer, Steven R.

    2005-01-01

    The paper discusses the following: 1. No-cost Extension. The no-cost extension is required to complete the work on the unified model codes (both hydrodynamic and kinetic Monte Carlo) as described in the initial proposal and previous annual reports. 2. Scientific Accomplishments during the Report Period. We completed a comprehensive model of Alfvtn wave reflection that spans the full distance from the photosphere to the distant heliosphere. 3. Comparison of Accomplishments with Proposed Goals. The proposal contained two specific objectives for Year 3: (1) to complete the unified model code, and (2) to apply it to various kinds of coronal holes (and polar plumes within coronal holes). Although the anticipated route toward these two final goals has changed (see accomplishments 2a and 2b above), they remain the major milestones for the extended period of performance. Accomplishments la and IC were necessary prerequisites for the derivation of "physically relevant transport and mode-coupling terms" for the unified model codes (as stated in the proposal Year 3 goals). We have fulfilled the proposed "core work" to study 4 general types of physical processes; in previous years we studied turbulence, mode coupling (Le., non-WKB reflection), and kinetic wave damping, and accomplishment lb provides the fourth topic: nonlinear steepening.

  17. Exploring Environmental Factors in Nursing Workplaces That Promote Psychological Resilience: Constructing a Unified Theoretical Model.

    PubMed

    Cusack, Lynette; Smith, Morgan; Hegney, Desley; Rees, Clare S; Breen, Lauren J; Witt, Regina R; Rogers, Cath; Williams, Allison; Cross, Wendy; Cheung, Kin

    2016-01-01

    Building nurses' resilience to complex and stressful practice environments is necessary to keep skilled nurses in the workplace and ensuring safe patient care. A unified theoretical framework titled Health Services Workplace Environmental Resilience Model (HSWERM), is presented to explain the environmental factors in the workplace that promote nurses' resilience. The framework builds on a previously-published theoretical model of individual resilience, which identified the key constructs of psychological resilience as self-efficacy, coping and mindfulness, but did not examine environmental factors in the workplace that promote nurses' resilience. This unified theoretical framework was developed using a literary synthesis drawing on data from international studies and literature reviews on the nursing workforce in hospitals. The most frequent workplace environmental factors were identified, extracted and clustered in alignment with key constructs for psychological resilience. Six major organizational concepts emerged that related to a positive resilience-building workplace and formed the foundation of the theoretical model. Three concepts related to nursing staff support (professional, practice, personal) and three related to nursing staff development (professional, practice, personal) within the workplace environment. The unified theoretical model incorporates these concepts within the workplace context, linking to the nurse, and then impacting on personal resilience and workplace outcomes, and its use has the potential to increase staff retention and quality of patient care.

  18. Dark Matter from SUGRA GUTs: mSUGRA, NUSUGRA and Yukawa-unified SUGRA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baer, Howard

    2009-09-08

    Gravity-mediated SUSY breaking models with R-parity conservation give rise to dark matter in the universe. I review neutralino dark matter in the minimal supergravity model (mSUGRA), models with non-universal soft SUSY breaking terms (NUSUGRA) which yield a well-tempered neutralino, and models with unified Yukawa couplings at the GUT scale (as may occur in an SO(10) SUSY GUT theory). These latter models have difficulty accomodating neutralino dark matter, but work very well if the dark matter particles are axions and axinos.

  19. Development of a unified constitutive model for an isotropic nickel base superalloy Rene 80

    NASA Technical Reports Server (NTRS)

    Ramaswamy, V. G.; Vanstone, R. H.; Laflen, J. H.; Stouffer, D. C.

    1988-01-01

    Accurate analysis of stress-strain behavior is of critical importance in the evaluation of life capabilities of hot section turbine engine components such as turbine blades and vanes. The constitutive equations used in the finite element analysis of such components must be capable of modeling a variety of complex behavior exhibited at high temperatures by cast superalloys. The classical separation of plasticity and creep employed in most of the finite element codes in use today is known to be deficient in modeling elevated temperature time dependent phenomena. Rate dependent, unified constitutive theories can overcome many of these difficulties. A new unified constitutive theory was developed to model the high temperature, time dependent behavior of Rene' 80 which is a cast turbine blade and vane nickel base superalloy. Considerations in model development included the cyclic softening behavior of Rene' 80, rate independence at lower temperatures and the development of a new model for static recovery.

  20. A Unified Framework for Analyzing and Designing for Stationary Arterial Networks

    DOT National Transportation Integrated Search

    2017-05-17

    This research aims to develop a unified theoretical and simulation framework for analyzing and designing signals for stationary arterial networks. Existing traffic flow models used in design and analysis of signal control strategies are either too si...

  1. A combined model for pseudo-rapidity distributions in Cu-Cu collisions at BNL-RHIC energies

    NASA Astrophysics Data System (ADS)

    Jiang, Z. J.; Wang, J.; Huang, Y.

    2016-04-01

    The charged particles produced in nucleus-nucleus collisions come from leading particles and those frozen out from the hot and dense matter created in collisions. The leading particles are conventionally supposed having Gaussian rapidity distributions normalized to the number of participants. The hot and dense matter is assumed to expand according to the unified hydrodynamics, a hydro model which unifies the features of Landau and Hwa-Bjorken model, and freeze out into charged particles from a time-like hypersurface with a proper time of τFO. The rapidity distribution of this part of charged particles can be derived analytically. The combined contribution from both leading particles and unified hydrodynamics is then compared against the experimental data performed by BNL-RHIC-PHOBOS Collaboration in different centrality Cu-Cu collisions at sNN = 200 and 62.4GeV, respectively. The model predictions are consistent with experimental measurements.

  2. A unified approach to computer analysis and modeling of spacecraft environmental interactions

    NASA Technical Reports Server (NTRS)

    Katz, I.; Mandell, M. J.; Cassidy, J. J.

    1986-01-01

    A new, coordinated, unified approach to the development of spacecraft plasma interaction models is proposed. The objective is to eliminate the unnecessary duplicative work in order to allow researchers to concentrate on the scientific aspects. By streamlining the developmental process, the interchange between theories and experimentalists is enhanced, and the transfer of technology to the spacecraft engineering community is faster. This approach is called the UNIfied Spacecraft Interaction Model (UNISIM). UNISIM is a coordinated system of software, hardware, and specifications. It is a tool for modeling and analyzing spacecraft interactions. It will be used to design experiments, to interpret results of experiments, and to aid in future spacecraft design. It breaks a Spacecraft Ineraction analysis into several modules. Each module will perform an analysis for some physical process, using phenomenology and algorithms which are well documented and have been subject to review. This system and its characteristics are discussed.

  3. Campus Single Sign-On und hochschulübergreifendes Identity Management

    NASA Astrophysics Data System (ADS)

    Hommel, Wolfgang

    Das im Rahmen von IntegraTUM für die TUM geschaffene Identity & Access Management System setzt das Paradigma unified login um, d. h. ein Benutzer kann alle für ihn relevanten Dienste innerhalb der Hochschule mit derselben Loginname-/Passwortkombination nutzen. Dieser Artikel zeigt, wie auf Basis der Software Shibboleth und der deutschlandweiten Hochschulföderation DFN-AAI als weitere Mehrwerte das campusweite web single sign-on und die nahtlose Nutzung zahlreicher externer Web-Anwendungen erreicht werden. Als Beispiel für die Abläufe bei der Erschließung neuer Dienste für die hochschulübergreifende Nutzung wird die Anbindung von Learning Management Systemen auf Basis des DFN-AAI E-Learning-Profils diskutiert. Den umfassenden Vorteilen werden schließlich die aktuellen technischen Grenzen bei der Umsetzung des hochschulübergreifenden Identity Management gegenübergestellt.

  4. Preliminary Development of a Unified Viscoplastic Constitutive Model for Alloy 617 with Special Reference to Long Term Creep Behavior

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sham, Sam; Walker, Kevin P.

    The expected service life of the Next Generation Nuclear Plant is 60 years. Structural analyses of the Intermediate Heat Exchanger (IHX) will require the development of unified viscoplastic constitutive models that address the material behavior of Alloy 617, a construction material of choice, over a wide range of strain rates. Many unified constitutive models employ a yield stress state variable which is used to account for cyclic hardening and softening of the material. For low stress values below the yield stress state variable these constitutive models predict that no inelastic deformation takes place which is contrary to experimental results. Themore » ability to model creep deformation at low stresses for the IHX application is very important as the IHX operational stresses are restricted to very small values due to the low creep strengths at elevated temperatures and long design lifetime. This paper presents some preliminary work in modeling the unified viscoplastic constitutive behavior of Alloy 617 which accounts for the long term, low stress, creep behavior and the hysteretic behavior of the material at elevated temperatures. The preliminary model is presented in one-dimensional form for ease of understanding, but the intent of the present work is to produce a three-dimensional model suitable for inclusion in the user subroutines UMAT and USERPL of the ABAQUS and ANSYS nonlinear finite element codes. Further experiments and constitutive modeling efforts are planned to model the material behavior of Alloy 617 in more detail.« less

  5. A unified 3D default space consciousness model combining neurological and physiological processes that underlie conscious experience

    PubMed Central

    Jerath, Ravinder; Crawford, Molly W.; Barnes, Vernon A.

    2015-01-01

    The Global Workspace Theory and Information Integration Theory are two of the most currently accepted consciousness models; however, these models do not address many aspects of conscious experience. We compare these models to our previously proposed consciousness model in which the thalamus fills-in processed sensory information from corticothalamic feedback loops within a proposed 3D default space, resulting in the recreation of the internal and external worlds within the mind. This 3D default space is composed of all cells of the body, which communicate via gap junctions and electrical potentials to create this unified space. We use 3D illustrations to explain how both visual and non-visual sensory information may be filled-in within this dynamic space, creating a unified seamless conscious experience. This neural sensory memory space is likely generated by baseline neural oscillatory activity from the default mode network, other salient networks, brainstem, and reticular activating system. PMID:26379573

  6. A unified model explains commonness and rarity on coral reefs.

    PubMed

    Connolly, Sean R; Hughes, Terry P; Bellwood, David R

    2017-04-01

    Abundance patterns in ecological communities have important implications for biodiversity maintenance and ecosystem functioning. However, ecological theory has been largely unsuccessful at capturing multiple macroecological abundance patterns simultaneously. Here, we propose a parsimonious model that unifies widespread ecological relationships involving local aggregation, species-abundance distributions, and species associations, and we test this model against the metacommunity structure of reef-building corals and coral reef fishes across the western and central Pacific. For both corals and fishes, the unified model simultaneously captures extremely well local species-abundance distributions, interspecific variation in the strength of spatial aggregation, patterns of community similarity, species accumulation, and regional species richness, performing far better than alternative models also examined here and in previous work on coral reefs. Our approach contributes to the development of synthetic theory for large-scale patterns of community structure in nature, and to addressing ongoing challenges in biodiversity conservation at macroecological scales. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

  7. Concentration-driven models revisited: towards a unified framework to model settling tanks in water resource recovery facilities.

    PubMed

    Torfs, Elena; Martí, M Carmen; Locatelli, Florent; Balemans, Sophie; Bürger, Raimund; Diehl, Stefan; Laurent, Julien; Vanrolleghem, Peter A; François, Pierre; Nopens, Ingmar

    2017-02-01

    A new perspective on the modelling of settling behaviour in water resource recovery facilities is introduced. The ultimate goal is to describe in a unified way the processes taking place both in primary settling tanks (PSTs) and secondary settling tanks (SSTs) for a more detailed operation and control. First, experimental evidence is provided, pointing out distributed particle properties (such as size, shape, density, porosity, and flocculation state) as an important common source of distributed settling behaviour in different settling unit processes and throughout different settling regimes (discrete, hindered and compression settling). Subsequently, a unified model framework that considers several particle classes is proposed in order to describe distributions in settling behaviour as well as the effect of variations in particle properties on the settling process. The result is a set of partial differential equations (PDEs) that are valid from dilute concentrations, where they correspond to discrete settling, to concentrated suspensions, where they correspond to compression settling. Consequently, these PDEs model both PSTs and SSTs.

  8. Addressing Learning Style Criticism: The Unified Learning Style Model Revisited

    NASA Astrophysics Data System (ADS)

    Popescu, Elvira

    Learning style is one of the individual differences that play an important but controversial role in the learning process. This paper aims at providing a critical analysis regarding learning styles and their use in technology enhanced learning. The identified criticism issues are addressed by reappraising the so called Unified Learning Style Model (ULSM). A detailed description of the ULSM components is provided, together with their rationale. The practical applicability of the model in adaptive web-based educational systems and its advantages versus traditional learning style models are also outlined.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Arnowitt, R.; Nath, P.

    A survey is given of supersymmetry and supergravity and their phenomenology. Some of the topics discussed are the basic ideas of global supersymmetry, the minimal supersymmetric Standard Model (MSSM) and its phenomenology, the basic ideas of local supersymmetry (supergravity), grand unification, supersymmetry breaking in supergravity grand unified models, radiative breaking of SU(2) {times} U(1), proton decay, cosmological constraints, and predictions of supergravity grand unified models. While the number of detailed derivations are necessarily limited, a sufficient number of results are given so that a reader can get a working knowledge of this field.

  10. Finite element implementation of Robinson's unified viscoplastic model and its application to some uniaxial and multiaxial problems

    NASA Technical Reports Server (NTRS)

    Arya, V. K.; Kaufman, A.

    1989-01-01

    A description of the finite element implementation of Robinson's unified viscoplastic model into the General Purpose Finite Element Program (MARC) is presented. To demonstrate its application, the implementation is applied to some uniaxial and multiaxial problems. A comparison of the results for the multiaxial problem of a thick internally pressurized cylinder, obtained using the finite element implementation and an analytical solution, is also presented. The excellent agreement obtained confirms the correct finite element implementation of Robinson's model.

  11. Finite element implementation of Robinson's unified viscoplastic model and its application to some uniaxial and multiaxial problems

    NASA Technical Reports Server (NTRS)

    Arya, V. K.; Kaufman, A.

    1987-01-01

    A description of the finite element implementation of Robinson's unified viscoplastic model into the General Purpose Finite Element Program (MARC) is presented. To demonstrate its application, the implementation is applied to some uniaxial and multiaxial problems. A comparison of the results for the multiaxial problem of a thick internally pressurized cylinder, obtained using the finite element implementation and an analytical solution, is also presented. The excellent agreement obtained confirms the correct finite element implementation of Robinson's model.

  12. On unified modeling, theory, and method for solving multi-scale global optimization problems

    NASA Astrophysics Data System (ADS)

    Gao, David Yang

    2016-10-01

    A unified model is proposed for general optimization problems in multi-scale complex systems. Based on this model and necessary assumptions in physics, the canonical duality theory is presented in a precise way to include traditional duality theories and popular methods as special applications. Two conjectures on NP-hardness are proposed, which should play important roles for correctly understanding and efficiently solving challenging real-world problems. Applications are illustrated for both nonconvex continuous optimization and mixed integer nonlinear programming.

  13. Effects of Positive Unified Behavior Support on Instruction

    ERIC Educational Resources Information Center

    Scott, John S.; White, Richard; Algozzine, Bob; Algozzine, Kate

    2009-01-01

    "Positive Unified Behavior Support" (PUBS) is a school-wide intervention designed to establish uniform attitudes, expectations, correction procedures, and roles among faculty, staff, and administration. PUBS is grounded in the general principles of positive behavior support and represents a straightforward, practical implementation model. When…

  14. A unified architecture for biomedical search engines based on semantic web technologies.

    PubMed

    Jalali, Vahid; Matash Borujerdi, Mohammad Reza

    2011-04-01

    There is a huge growth in the volume of published biomedical research in recent years. Many medical search engines are designed and developed to address the over growing information needs of biomedical experts and curators. Significant progress has been made in utilizing the knowledge embedded in medical ontologies and controlled vocabularies to assist these engines. However, the lack of common architecture for utilized ontologies and overall retrieval process, hampers evaluating different search engines and interoperability between them under unified conditions. In this paper, a unified architecture for medical search engines is introduced. Proposed model contains standard schemas declared in semantic web languages for ontologies and documents used by search engines. Unified models for annotation and retrieval processes are other parts of introduced architecture. A sample search engine is also designed and implemented based on the proposed architecture in this paper. The search engine is evaluated using two test collections and results are reported in terms of precision vs. recall and mean average precision for different approaches used by this search engine.

  15. BRDF profile of Tyvek and its implementation in the Geant4 simulation toolkit.

    PubMed

    Nozka, Libor; Pech, Miroslav; Hiklova, Helena; Mandat, Dusan; Hrabovsky, Miroslav; Schovanek, Petr; Palatka, Miroslav

    2011-02-28

    Diffuse and specular characteristics of the Tyvek 1025-BL material are reported with respect to their implementation in the Geant4 Monte Carlo simulation toolkit. This toolkit incorporates the UNIFIED model. Coefficients defined by the UNIFIED model were calculated from the bidirectional reflectance distribution function (BRDF) profiles measured with a scatterometer for several angles of incidence. Results were amended with profile measurements made by a profilometer.

  16. A Unified Air-Sea Visualization System: Survey on Gridding Structures

    NASA Technical Reports Server (NTRS)

    Anand, Harsh; Moorhead, Robert

    1995-01-01

    The goal is to develop a Unified Air-Sea Visualization System (UASVS) to enable the rapid fusion of observational, archival, and model data for verification and analysis. To design and develop UASVS, modelers were polled to determine the gridding structures and visualization systems used, and their needs with respect to visual analysis. A basic UASVS requirement is to allow a modeler to explore multiple data sets within a single environment, or to interpolate multiple datasets onto one unified grid. From this survey, the UASVS should be able to visualize 3D scalar/vector fields; render isosurfaces; visualize arbitrary slices of the 3D data; visualize data defined on spectral element grids with the minimum number of interpolation stages; render contours; produce 3D vector plots and streamlines; provide unified visualization of satellite images, observations and model output overlays; display the visualization on a projection of the users choice; implement functions so the user can derive diagnostic values; animate the data to see the time-evolution; animate ocean and atmosphere at different rates; store the record of cursor movement, smooth the path, and animate a window around the moving path; repeatedly start and stop the visual time-stepping; generate VHS tape animations; work on a variety of workstations; and allow visualization across clusters of workstations and scalable high performance computer systems.

  17. Unified Mie and fractal scattering by cells and experimental study on application in optical characterization of cellular and subcellular structures.

    PubMed

    Xu, Min; Wu, Tao T; Qu, Jianan Y

    2008-01-01

    A unified Mie and fractal model for light scattering by biological cells is presented. This model is shown to provide an excellent global agreement with the angular dependent elastic light scattering spectroscopy of cells over the whole visible range (400 to 700 nm) and at all scattering angles (1.1 to 165 deg) investigated. Mie scattering from the bare cell and the nucleus is found to dominate light scattering in the forward directions, whereas the random fluctuation of the background refractive index within the cell, behaving as a fractal random continuous medium, is found to dominate light scattering at other angles. Angularly dependent elastic light scattering spectroscopy aided by the unified Mie and fractal model is demonstrated to be an effective noninvasive approach to characterize biological cells and their internal structures. The acetowhitening effect induced by applying acetic acid on epithelial cells is investigated as an example. The changes in morphology and refractive index of epithelial cells, nuclei, and subcellular structures after the application of acetic acid are successfully probed and quantified using the proposed approach. The unified Mie and fractal model may serve as the foundation for optical detection of precancerous and cancerous changes in biological cells and tissues based on light scattering techniques.

  18. Exploring Environmental Factors in Nursing Workplaces That Promote Psychological Resilience: Constructing a Unified Theoretical Model

    PubMed Central

    Cusack, Lynette; Smith, Morgan; Hegney, Desley; Rees, Clare S.; Breen, Lauren J.; Witt, Regina R.; Rogers, Cath; Williams, Allison; Cross, Wendy; Cheung, Kin

    2016-01-01

    Building nurses' resilience to complex and stressful practice environments is necessary to keep skilled nurses in the workplace and ensuring safe patient care. A unified theoretical framework titled Health Services Workplace Environmental Resilience Model (HSWERM), is presented to explain the environmental factors in the workplace that promote nurses' resilience. The framework builds on a previously-published theoretical model of individual resilience, which identified the key constructs of psychological resilience as self-efficacy, coping and mindfulness, but did not examine environmental factors in the workplace that promote nurses' resilience. This unified theoretical framework was developed using a literary synthesis drawing on data from international studies and literature reviews on the nursing workforce in hospitals. The most frequent workplace environmental factors were identified, extracted and clustered in alignment with key constructs for psychological resilience. Six major organizational concepts emerged that related to a positive resilience-building workplace and formed the foundation of the theoretical model. Three concepts related to nursing staff support (professional, practice, personal) and three related to nursing staff development (professional, practice, personal) within the workplace environment. The unified theoretical model incorporates these concepts within the workplace context, linking to the nurse, and then impacting on personal resilience and workplace outcomes, and its use has the potential to increase staff retention and quality of patient care. PMID:27242567

  19. SO(10) × S 4 grand unified theory of flavour and leptogenesis

    NASA Astrophysics Data System (ADS)

    de Anda, Francisco J.; King, Stephen F.; Perdomo, Elena

    2017-12-01

    We propose a Grand Unified Theory of Flavour, based on SO(10) together with a non-Abelian discrete group S 4, under which the unified three quark and lepton 16-plets are unified into a single triplet 3'. The model involves a further discrete group ℤ 4 R × ℤ 4 3 which controls the Higgs and flavon symmetry breaking sectors. The CSD2 flavon vacuum alignment is discussed, along with the GUT breaking potential and the doublet-triplet splitting, and proton decay is shown to be under control. The Yukawa matrices are derived in detail, from renormalisable diagrams, and neutrino masses emerge from the type I seesaw mechanism. A full numerical fit is performed with 15 input parameters generating 19 presently constrained observables, taking into account supersymmetry threshold corrections. The model predicts a normal neutrino mass ordering with a CP oscillation phase of 260°, an atmospheric angle in the first octant and neutrinoless double beta decay with m ββ = 11 meV. We discuss N 2 leptogenesis, which fixes the second right-handed neutrino mass to be M 2 ≃ 2 × 1011 GeV, in the natural range predicted by the model.

  20. The unified model of vegetarian identity: A conceptual framework for understanding plant-based food choices.

    PubMed

    Rosenfeld, Daniel L; Burrow, Anthony L

    2017-05-01

    By departing from social norms regarding food behaviors, vegetarians acquire membership in a distinct social group and can develop a salient vegetarian identity. However, vegetarian identities are diverse, multidimensional, and unique to each individual. Much research has identified fundamental psychological aspects of vegetarianism, and an identity framework that unifies these findings into common constructs and conceptually defines variables is needed. Integrating psychological theories of identity with research on food choices and vegetarianism, this paper proposes a conceptual model for studying vegetarianism: The Unified Model of Vegetarian Identity (UMVI). The UMVI encompasses ten dimensions-organized into three levels (contextual, internalized, and externalized)-that capture the role of vegetarianism in an individual's self-concept. Contextual dimensions situate vegetarianism within contexts; internalized dimensions outline self-evaluations; and externalized dimensions describe enactments of identity through behavior. Together, these dimensions form a coherent vegetarian identity, characterizing one's thoughts, feelings, and behaviors regarding being vegetarian. By unifying dimensions that capture psychological constructs universally, the UMVI can prevent discrepancies in operationalization, capture the inherent diversity of vegetarian identities, and enable future research to generate greater insight into how people understand themselves and their food choices. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Grand unified brane world scenario

    NASA Astrophysics Data System (ADS)

    Arai, Masato; Blaschke, Filip; Eto, Minoru; Sakai, Norisuke

    2017-12-01

    We present a field theoretical model unifying grand unified theory (GUT) and brane world scenario. As a concrete example, we consider S U (5 ) GUT in 4 +1 dimensions where our 3 +1 dimensional spacetime spontaneously arises on five domain walls. A field-dependent gauge kinetic term is used to localize massless non-Abelian gauge fields on the domain walls and to assure the charge universality of matter fields. We find the domain walls with the symmetry breaking S U (5 )→S U (3 )×S U (2 )×U (1 ) as a global minimum and all the undesirable moduli are stabilized with the mass scale of MGUT. Profiles of massless standard model particles are determined as a consequence of wall dynamics. The proton decay can be exponentially suppressed.

  2. Simulation of Aerosols and Chemistry with a Unified Global Model

    NASA Technical Reports Server (NTRS)

    Chin, Mian

    2004-01-01

    This project is to continue the development of the global simulation capabilities of tropospheric and stratospheric chemistry and aerosols in a unified global model. This is a part of our overall investigation of aerosol-chemistry-climate interaction. In the past year, we have enabled the tropospheric chemistry simulations based on the GEOS-CHEM model, and added stratospheric chemical reactions into the GEOS-CHEM such that a globally unified troposphere-stratosphere chemistry and transport can be simulated consistently without any simplifications. The tropospheric chemical mechanism in the GEOS-CHEM includes 80 species and 150 reactions. 24 tracers are transported, including O3, NOx, total nitrogen (NOy), H2O2, CO, and several types of hydrocarbon. The chemical solver used in the GEOS-CHEM model is a highly accurate sparse-matrix vectorized Gear solver (SMVGEAR). The stratospheric chemical mechanism includes an additional approximately 100 reactions and photolysis processes. Because of the large number of total chemical reactions and photolysis processes and very different photochemical regimes involved in the unified simulation, the model demands significant computer resources that are currently not practical. Therefore, several improvements will be taken, such as massive parallelization, code optimization, or selecting a faster solver. We have also continued aerosol simulation (including sulfate, dust, black carbon, organic carbon, and sea-salt) in the global model to cover most of year 2002. These results have been made available to many groups worldwide and accessible from the website http://code916.gsfc.nasa.gov/People/Chin/aot.html.

  3. Parameterisation of Orographic Cloud Dynamics in a GCM

    DTIC Science & Technology

    2007-01-01

    makes use of both satellite observations of a case study, and a simulation in which the Unified Model is nudged to- wards ERA-40 assimilated winds...this parameterisation makes use of both satellite observations of a case study, and a simulation in which the Unified Model is nudged towards ERA-40...by ANSI Std Z39-18 et al. (1999), predicted the temperature perturbations in the lower stratosphere which can influence polar stratospheric clouds

  4. Unified concept of effective one component plasma for hot dense plasmas

    DOE PAGES

    Clerouin, Jean; Arnault, Philippe; Ticknor, Christopher; ...

    2016-03-17

    Orbital-free molecular dynamics simulations are used to benchmark two popular models for hot dense plasmas: the one component plasma (OCP) and the Yukawa model. A unified concept emerges where an effective OCP (EOCP) is constructed from the short-range structure of the plasma. An unambiguous ionization and the screening length can be defined and used for a Yukawa system, which reproduces the long-range structure with finite compressibility. Similarly, the dispersion relation of longitudinal waves is consistent with the screened model at vanishing wave number but merges with the OCP at high wave number. Additionally, the EOCP reproduces the overall relaxation timemore » scales of the correlation functions associated with ionic motion. Lastly, in the hot dense regime, this unified concept of EOCP can be fruitfully applied to deduce properties such as the equation of state, ionic transport coefficients, and the ion feature in x-ray Thomson scattering experiments.« less

  5. A Unified Model for Predicting the Open Hole Tensile and Compressive Strengths of Composite Laminates for Aerospace Applications

    NASA Technical Reports Server (NTRS)

    Davidson, Paul; Pineda, Evan J.; Heinrich, Christian; Waas, Anthony M.

    2013-01-01

    The open hole tensile and compressive strengths are important design parameters in qualifying fiber reinforced laminates for a wide variety of structural applications in the aerospace industry. In this paper, we present a unified model that can be used for predicting both these strengths (tensile and compressive) using the same set of coupon level, material property data. As a prelude to the unified computational model that follows, simplified approaches, referred to as "zeroth order", "first order", etc. with increasing levels of fidelity are first presented. The results and methods presented are practical and validated against experimental data. They serve as an introductory step in establishing a virtual building block, bottom-up approach to designing future airframe structures with composite materials. The results are useful for aerospace design engineers, particularly those that deal with airframe design.

  6. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, W.K.; Anderson, D.; Atlas, R.; Chern, J.; Houser, P.; Hou, A.; Lang, S.; Lau, W.; Peters-Lidard, C.; Kakar, R.; hide

    2008-01-01

    Numerical cloud resolving models (CRMs), which are based the non-hydrostatic equations of motion, have been extensively applied to cloud-scale and mesoscale processes during the past four decades. Recent GEWEX Cloud System Study (GCSS) model comparison projects have indicated that CRMs agree with observations in simulating various types of clouds and cloud systems from different geographic locations. Cloud resolving models now provide statistical information useful for developing more realistic physically based parameterizations for climate models and numerical weather prediction models. It is also expected that Numerical Weather Prediction (NWP) and regional scale model can be run in grid size similar to cloud resolving model through nesting technique. Current and future NASA satellite programs can provide cloud, precipitation, aerosol and other data at very fine spatial and temporal scales. It requires a coupled global circulation model (GCM) and cloud-scale model (termed a szrper-parameterization or multi-scale modeling -framework, MMF) to use these satellite data to improve the understanding of the physical processes that are responsible for the variation in global and regional climate and hydrological systems. The use of a GCM will enable global coverage, and the use of a CRM will allow for better and more sophisticated physical parameterization. NASA satellite and field campaign can provide initial conditions as well as validation through utilizing the Earth Satellite simulators. At Goddard, we have developed a multi-scale modeling system with unified physics. The modeling system consists a coupled GCM-CRM (or MMF); a state-of-the-art weather research forecast model (WRF) and a cloud-resolving model (Goddard Cumulus Ensemble model). In these models, the same microphysical schemes (2ICE, several 3ICE), radiation (including explicitly calculated cloud optical properties), and surface models are applied. In addition, a comprehensive unified Earth Satellite simulator has been developed at GSFC, which is designed to fully utilize the multi-scale modeling system. A brief review of the multi-scale modeling system with unified physics/simulator and examples is presented in this article.

  7. Asian summer monsoon seasonal prediction skill in the Met Office GloSea5 model and its dependence on mean state biases

    NASA Astrophysics Data System (ADS)

    Bush, Stephanie; Turner, Andrew; Martin, Gill; Woolnough, Steve

    2015-04-01

    Predicting the circulation and precipitation features of the Asian monsoon on time scales of weeks to the season ahead remains a challenge for prediction centres. Current state-of-the-art models retain large biases, particularly dryness over India, which evolve rapidly from initialization and persist into centennial length climate integrations, illustrating the seamless nature of the monsoon problem. We present initial results from our Ministry of Earth Sciences Indian Monsoon Mission collaboration project to assess and improve weekly-to-seasonal forecasts in the Met Office Unified Model (MetUM) coupled initialized Global Seasonal Prediction System (GloSea5). Using a 14-year hindcast ensemble of integrations in which atmosphere, ocean and sea-ice components are initialized from May start dates, we assess the monsoon seasonal prediction skill and global mean state biases of GloSea5. Initial May and June biases include a lack of precipitation over the Indian peninsula, and a weakened monsoon flow, and these give way to a more robust pattern of excess precipitation in the western north Pacific, lack of precipitation over the Maritime Continent, excess westerlies across the Indian peninsula and Indochina, and cool SSTs in the eastern equatorial Indian Ocean and western north Pacific in July and August. Despite these mean state biases, the interannual correlation of predicted JJA all India rainfall from 1998 to 2009 with TRMM is fairly high at 0.68. Future work will focus on the prospects for further improving this skill with bias correction techniques.

  8. A Unified Fault-Tolerance Protocol

    NASA Technical Reports Server (NTRS)

    Miner, Paul; Gedser, Alfons; Pike, Lee; Maddalon, Jeffrey

    2004-01-01

    Davies and Wakerly show that Byzantine fault tolerance can be achieved by a cascade of broadcasts and middle value select functions. We present an extension of the Davies and Wakerly protocol, the unified protocol, and its proof of correctness. We prove that it satisfies validity and agreement properties for communication of exact values. We then introduce bounded communication error into the model. Inexact communication is inherent for clock synchronization protocols. We prove that validity and agreement properties hold for inexact communication, and that exact communication is a special case. As a running example, we illustrate the unified protocol using the SPIDER family of fault-tolerant architectures. In particular we demonstrate that the SPIDER interactive consistency, distributed diagnosis, and clock synchronization protocols are instances of the unified protocol.

  9. Toward a Unified Science Curriculum.

    ERIC Educational Resources Information Center

    Showalter, Victor M.

    The two major models of science curriculum change, textbook revision and national curriculum projects, are derived from, and reinforce, the present curriculum structure. This is undesirable in a time of increasing fluidity and change, because adaptation to new situations is difficult. Unified science, based on the premise that science is a unity,…

  10. In Search of a Unified Model of Language Contact

    ERIC Educational Resources Information Center

    Winford, Donald

    2013-01-01

    Much previous research has pointed to the need for a unified framework for language contact phenomena -- one that would include social factors and motivations, structural factors and linguistic constraints, and psycholinguistic factors involved in processes of language processing and production. While Contact Linguistics has devoted a great deal…

  11. A unified account of tilt illusions, association fields, and contour detection based on elastica.

    PubMed

    Keemink, Sander W; van Rossum, Mark C W

    2016-09-01

    As expressed in the Gestalt law of good continuation, human perception tends to associate stimuli that form smooth continuations. Contextual modulation in primary visual cortex, in the form of association fields, is believed to play an important role in this process. Yet a unified and principled account of the good continuation law on the neural level is lacking. In this study we introduce a population model of primary visual cortex. Its contextual interactions depend on the elastica curvature energy of the smoothest contour connecting oriented bars. As expected, this model leads to association fields consistent with data. However, in addition the model displays tilt-illusions for stimulus configurations with grating and single bars that closely match psychophysics. Furthermore, the model explains not only pop-out of contours amid a variety of backgrounds, but also pop-out of single targets amid a uniform background. We thus propose that elastica is a unifying principle of the visual cortical network. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Unified tensor model for space-frequency spreading-multiplexing (SFSM) MIMO communication systems

    NASA Astrophysics Data System (ADS)

    de Almeida, André LF; Favier, Gérard

    2013-12-01

    This paper presents a unified tensor model for space-frequency spreading-multiplexing (SFSM) multiple-input multiple-output (MIMO) wireless communication systems that combine space- and frequency-domain spreadings, followed by a space-frequency multiplexing. Spreading across space (transmit antennas) and frequency (subcarriers) adds resilience against deep channel fades and provides space and frequency diversities, while orthogonal space-frequency multiplexing enables multi-stream transmission. We adopt a tensor-based formulation for the proposed SFSM MIMO system that incorporates space, frequency, time, and code dimensions by means of the parallel factor model. The developed SFSM tensor model unifies the tensorial formulation of some existing multiple-access/multicarrier MIMO signaling schemes as special cases, while revealing interesting tradeoffs due to combined space, frequency, and time diversities which are of practical relevance for joint symbol-channel-code estimation. The performance of the proposed SFSM MIMO system using either a zero forcing receiver or a semi-blind tensor-based receiver is illustrated by means of computer simulation results under realistic channel and system parameters.

  13. Inference of viscosity jump at 670 km depth and lower mantle viscosity structure from GIA observations

    NASA Astrophysics Data System (ADS)

    Nakada, Masao; Okuno, Jun'ichi; Irie, Yoshiya

    2018-03-01

    A viscosity model with an exponential profile described by temperature (T) and pressure (P) distributions and constant activation energy (E_{{{um}}}^{{*}} for the upper mantle and E_{{{lm}}}^* for the lower mantle) and volume (V_{{{um}}}^{{*}} and V_{{{lm}}}^*) is employed in inferring the viscosity structure of the Earth's mantle from observations of glacial isostatic adjustment (GIA). We first construct standard viscosity models with an average upper-mantle viscosity ({\\bar{η }_{{{um}}}}) of 2 × 1020 Pa s, a typical value for the oceanic upper-mantle viscosity, satisfying the observationally derived three GIA-related observables, GIA-induced rate of change of the degree-two zonal harmonic of the geopotential, {\\dot{J}_2}, and differential relative sea level (RSL) changes for the Last Glacial Maximum sea levels at Barbados and Bonaparte Gulf in Australia and for RSL changes at 6 kyr BP for Karumba and Halifax Bay in Australia. Standard viscosity models inferred from three GIA-related observables are characterized by a viscosity of ˜1023 Pa s in the deep mantle for an assumed viscosity at 670 km depth, ηlm(670), of (1 - 50) × 1021 Pa s. Postglacial RSL changes at Southport, Bermuda and Everglades in the intermediate region of the North American ice sheet, largely dependent on its gross melting history, have a crucial potential for inference of a viscosity jump at 670 km depth. The analyses of these RSL changes based on the viscosity models with {\\bar{η }_{{{um}}}} ≥ 2 × 1020 Pa s and lower-mantle viscosity structures for the standard models yield permissible {\\bar{η }_{{{um}}}} and ηlm (670) values, although there is a trade-off between the viscosity and ice history models. Our preferred {\\bar{η }_{{{um}}}} and ηlm (670) values are ˜(7 - 9) × 1020 and ˜1022 Pa s, respectively, and the {\\bar{η }_{{{um}}}} is higher than that for the typical value of oceanic upper mantle, which may reflect a moderate laterally heterogeneous upper-mantle viscosity. The mantle viscosity structure adopted in this study depends on temperature distribution and activation energy and volume, and it is difficult to discuss the impact of each quantity on the inferred lower-mantle viscosity model. We conclude that models of smooth depth variation in the lower-mantle viscosity following η ( z ) ∝ {{ exp}}[ {( {E_{{{lm}}}^* + P( z )V_{{{lm}}}^*} )/{{R}}T( z )} ] with constant E_{{{lm}}}^* and V_{{{lm}}}^* are consistent with the GIA observations.

  14. Measuring and predicting sooting tendencies of oxygenates, alkanes, alkenes, cycloalkanes, and aromatics on a unified scale

    DOE PAGES

    Das, Dhrubajyoti D.; St. John, Peter C.; McEnally, Charles S.; ...

    2017-12-27

    Databases of sooting indices, based on measuring some aspect of sooting behavior in a standardized combustion environment, are useful in providing information on the comparative sooting tendencies of different fuels or pure compounds. However, newer biofuels have varied chemical structures including both aromatic and oxygenated functional groups, which expands the chemical space of relevant compounds. In this work, we propose a unified sooting tendency database for pure compounds, including both regular and oxygenated hydrocarbons, which is based on combining two disparate databases of yield-based sooting tendency measurements in the literature. Unification of the different databases was made possible by leveragingmore » the greater dynamic range of the color ratio pyrometry soot diagnostic. This unified database contains a substantial number of pure compounds (≥ 400 total) from multiple categories of hydrocarbons important in modern fuels and establishes the sooting tendencies of aromatic and oxygenated hydrocarbons on the same numeric scale for the first time. Then, using this unified sooting tendency database, we have developed a predictive model for sooting behavior applicable to a broad range of hydrocarbons and oxygenated hydrocarbons. The model decomposes each compound into single-carbon fragments and assigns a sooting tendency contribution to each fragment based on regression against the unified database. The model’s predictive accuracy (as demonstrated by leave-one-out cross-validation) is comparable to a previously developed, more detailed predictive model. The fitted model provides insight into the effects of chemical structure on soot formation, and cases where its predictions fail reveal the presence of more complicated kinetic sooting mechanisms. Our work will therefore enable the rational design of low-sooting fuel blends from a wide range of feedstocks and chemical functionalities.« less

  15. Measuring and predicting sooting tendencies of oxygenates, alkanes, alkenes, cycloalkanes, and aromatics on a unified scale

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Das, Dhrubajyoti D.; St. John, Peter C.; McEnally, Charles S.

    Databases of sooting indices, based on measuring some aspect of sooting behavior in a standardized combustion environment, are useful in providing information on the comparative sooting tendencies of different fuels or pure compounds. However, newer biofuels have varied chemical structures including both aromatic and oxygenated functional groups, which expands the chemical space of relevant compounds. In this work, we propose a unified sooting tendency database for pure compounds, including both regular and oxygenated hydrocarbons, which is based on combining two disparate databases of yield-based sooting tendency measurements in the literature. Unification of the different databases was made possible by leveragingmore » the greater dynamic range of the color ratio pyrometry soot diagnostic. This unified database contains a substantial number of pure compounds (≥ 400 total) from multiple categories of hydrocarbons important in modern fuels and establishes the sooting tendencies of aromatic and oxygenated hydrocarbons on the same numeric scale for the first time. Then, using this unified sooting tendency database, we have developed a predictive model for sooting behavior applicable to a broad range of hydrocarbons and oxygenated hydrocarbons. The model decomposes each compound into single-carbon fragments and assigns a sooting tendency contribution to each fragment based on regression against the unified database. The model’s predictive accuracy (as demonstrated by leave-one-out cross-validation) is comparable to a previously developed, more detailed predictive model. The fitted model provides insight into the effects of chemical structure on soot formation, and cases where its predictions fail reveal the presence of more complicated kinetic sooting mechanisms. Our work will therefore enable the rational design of low-sooting fuel blends from a wide range of feedstocks and chemical functionalities.« less

  16. Improving the accuracy in detection of clustered microcalcifications with a context-sensitive classification model.

    PubMed

    Wang, Juan; Nishikawa, Robert M; Yang, Yongyi

    2016-01-01

    In computer-aided detection of microcalcifications (MCs), the detection accuracy is often compromised by frequent occurrence of false positives (FPs), which can be attributed to a number of factors, including imaging noise, inhomogeneity in tissue background, linear structures, and artifacts in mammograms. In this study, the authors investigated a unified classification approach for combating the adverse effects of these heterogeneous factors for accurate MC detection. To accommodate FPs caused by different factors in a mammogram image, the authors developed a classification model to which the input features were adapted according to the image context at a detection location. For this purpose, the input features were defined in two groups, of which one group was derived from the image intensity pattern in a local neighborhood of a detection location, and the other group was used to characterize how a MC is different from its structural background. Owing to the distinctive effect of linear structures in the detector response, the authors introduced a dummy variable into the unified classifier model, which allowed the input features to be adapted according to the image context at a detection location (i.e., presence or absence of linear structures). To suppress the effect of inhomogeneity in tissue background, the input features were extracted from different domains aimed for enhancing MCs in a mammogram image. To demonstrate the flexibility of the proposed approach, the authors implemented the unified classifier model by two widely used machine learning algorithms, namely, a support vector machine (SVM) classifier and an Adaboost classifier. In the experiment, the proposed approach was tested for two representative MC detectors in the literature [difference-of-Gaussians (DoG) detector and SVM detector]. The detection performance was assessed using free-response receiver operating characteristic (FROC) analysis on a set of 141 screen-film mammogram (SFM) images (66 cases) and a set of 188 full-field digital mammogram (FFDM) images (95 cases). The FROC analysis results show that the proposed unified classification approach can significantly improve the detection accuracy of two MC detectors on both SFM and FFDM images. Despite the difference in performance between the two detectors, the unified classifiers can reduce their FP rate to a similar level in the output of the two detectors. In particular, with true-positive rate at 85%, the FP rate on SFM images for the DoG detector was reduced from 1.16 to 0.33 clusters/image (unified SVM) and 0.36 clusters/image (unified Adaboost), respectively; similarly, for the SVM detector, the FP rate was reduced from 0.45 clusters/image to 0.30 clusters/image (unified SVM) and 0.25 clusters/image (unified Adaboost), respectively. Similar FP reduction results were also achieved on FFDM images for the two MC detectors. The proposed unified classification approach can be effective for discriminating MCs from FPs caused by different factors (such as MC-like noise patterns and linear structures) in MC detection. The framework is general and can be applicable for further improving the detection accuracy of existing MC detectors.

  17. Food-web based unified model of macro- and microevolution.

    PubMed

    Chowdhury, Debashish; Stauffer, Dietrich

    2003-10-01

    We incorporate the generic hierarchical architecture of foodwebs into a "unified" model that describes both micro- and macroevolutions within a single theoretical framework. This model describes the microevolution in detail by accounting for the birth, ageing, and natural death of individual organisms as well as prey-predator interactions on a hierarchical dynamic food web. It also provides a natural description of random mutations and speciation (origination) of species as well as their extinctions. The distribution of lifetimes of species follows an approximate power law only over a limited regime.

  18. Using the Unified Modelling Language (UML) to guide the systemic description of biological processes and systems.

    PubMed

    Roux-Rouquié, Magali; Caritey, Nicolas; Gaubert, Laurent; Rosenthal-Sabroux, Camille

    2004-07-01

    One of the main issues in Systems Biology is to deal with semantic data integration. Previously, we examined the requirements for a reference conceptual model to guide semantic integration based on the systemic principles. In the present paper, we examine the usefulness of the Unified Modelling Language (UML) to describe and specify biological systems and processes. This makes unambiguous representations of biological systems, which would be suitable for translation into mathematical and computational formalisms, enabling analysis, simulation and prediction of these systems behaviours.

  19. The Met Office Coupled Atmosphere/Land/Ocean/Sea-Ice Data Assimilation System

    NASA Astrophysics Data System (ADS)

    Lea, Daniel; Mirouze, Isabelle; Martin, Matthew; Hines, Adrian; Guiavarch, Catherine; Shelly, Ann

    2014-05-01

    The Met Office has developed a weakly-coupled data assimilation (DA) system using the global coupled model HADGEM3 (Hadley Centre Global Environment Model, version 3). This model combines the atmospheric model UM (Unified Model) at 60 km horizontal resolution on 85 vertical levels, the ocean model NEMO (Nucleus for European Modeling of the Ocean) at 25 km (at the equator) horizontal resolution on 75 vertical levels, and the sea-ice model CICE at the same resolution as NEMO. The atmosphere and the ocean/sea-ice fields are coupled every 1-hour using the OASIS coupler. The coupled model is corrected using two separate 6-hour window data assimilation systems: a 4D-Var for the atmosphere with associated soil moisture content nudging and snow analysis schemes on the one hand, and a 3D-Var FGAT for the ocean and sea-ice on the other hand. The background information in the DA systems comes from a previous 6-hour forecast of the coupled model. To show the impact of coupled DA, one-month experiments have been carried out, including 1) a full atmosphere/land/ocean/sea-ice coupled DA run, 2) an atmosphere-only run forced by OSTIA SSTs and sea-ice with atmosphere and land DA, and 3) an ocean-only run forced by atmospheric fields from run 2 with ocean and sea-ice DA. In addition, 5-day forecast runs, started twice a day, have been produced from initial conditions generated by either run 1 or a combination of runs 2 and 3. The different results have been compared to each other and, whenever possible, to other references such as the Met Office atmosphere and ocean operational analyses or the OSTIA data. These all show the coupled DA system functioning well. Evidence of imbalances and initialisation shocks has also been looked for.

  20. Vector Autoregression, Structural Equation Modeling, and Their Synthesis in Neuroimaging Data Analysis

    PubMed Central

    Chen, Gang; Glen, Daniel R.; Saad, Ziad S.; Hamilton, J. Paul; Thomason, Moriah E.; Gotlib, Ian H.; Cox, Robert W.

    2011-01-01

    Vector autoregression (VAR) and structural equation modeling (SEM) are two popular brain-network modeling tools. VAR, which is a data-driven approach, assumes that connected regions exert time-lagged influences on one another. In contrast, the hypothesis-driven SEM is used to validate an existing connectivity model where connected regions have contemporaneous interactions among them. We present the two models in detail and discuss their applicability to FMRI data, and interpretational limits. We also propose a unified approach that models both lagged and contemporaneous effects. The unifying model, structural vector autoregression (SVAR), may improve statistical and explanatory power, and avoids some prevalent pitfalls that can occur when VAR and SEM are utilized separately. PMID:21975109

  1. An observational and modeling study of the August 2017 Florida climate extreme event.

    NASA Astrophysics Data System (ADS)

    Konduru, R.; Singh, V.; Routray, A.

    2017-12-01

    A special report on the climate extremes by the Intergovernmental Panel on Climate Change (IPCC) elucidates that the sole cause of disasters is due to the exposure and vulnerability of the human and natural system to the climate extremes. The cause of such a climate extreme could be anthropogenic or non-anthropogenic. Therefore, it is challenging to discern the critical factor of influence for a particular climate extreme. Such kind of perceptive study with reasonable confidence on climate extreme events is possible only if there exist any past case studies. A similar rarest climate extreme problem encountered in the case of Houston floods and extreme rainfall over Florida in August 2017. A continuum of hurricanes like Harvey and Irma targeted the Florida region and caused catastrophe. Due to the rarity of August 2017 Florida climate extreme event, it requires the in-depth study on this case. To understand the multi-faceted nature of the event, a study on the development of the Harvey hurricane and its progression and dynamics is significant. Current article focus on the observational and modeling study on the Harvey hurricane. A global model named as NCUM (The global UK Met office Unified Model (UM) operational at National Center for Medium Range Weather Forecasting, India, was utilized to simulate the Harvey hurricane. The simulated rainfall and wind fields were compared with the observational datasets like Tropical Rainfall Measuring Mission rainfall datasets and Era-Interim wind fields. The National Centre for Environmental Prediction (NCEP) automated tracking system was utilized to track the Harvey hurricane, and the tracks were analyzed statistically for different forecasts concerning the Harvey hurricane track of Joint Typhon Warning Centre. Further, the current study will be continued to investigate the atmospheric processes involved in the August 2017 Florida climate extreme event.

  2. Development of KIAPS Observation Processing Package for Data Assimilation System

    NASA Astrophysics Data System (ADS)

    Kang, Jeon-Ho; Chun, Hyoung-Wook; Lee, Sihye; Han, Hyun-Jun; Ha, Su-Jin

    2015-04-01

    The Korea Institute of Atmospheric Prediction Systems (KIAPS) was founded in 2011 by the Korea Meteorological Administration (KMA) to develop Korea's own global Numerical Weather Prediction (NWP) system as nine year (2011-2019) project. Data assimilation team at KIAPS has been developing the observation processing system (KIAPS Package for Observation Processing: KPOP) to provide optimal observations to the data assimilation system for the KIAPS Global Model (KIAPS Integrated Model - Spectral Element method based on HOMME: KIM-SH). Currently, the KPOP is capable of processing the satellite radiance data (AMSU-A, IASI), GPS Radio Occultation (GPS-RO), AIRCRAFT (AMDAR, AIREP, and etc…), and synoptic observation (SONDE and SURFACE). KPOP adopted Radiative Transfer for TOVS version 10 (RTTOV_v10) to get brightness temperature (TB) for each channel at top of the atmosphere (TOA), and Radio Occultation Processing Package (ROPP) 1-dimensional forward module to get bending angle (BA) at each tangent point. The observation data are obtained from the KMA which has been composited with BUFR format to be converted with ODB that are used for operational data assimilation and monitoring at the KMA. The Unified Model (UM), Community Atmosphere - Spectral Element (CAM-SE) and KIM-SH model outputs are used for the bias correction (BC) and quality control (QC) of the observations, respectively. KPOP provides radiance and RO data for Local Ensemble Transform Kalman Filter (LETKF) and also provides SONDE, SURFACE and AIRCRAFT data for Three-Dimensional Variational Assimilation (3DVAR). We are expecting all of the observation type which processed in KPOP could be combined with both of the data assimilation method as soon as possible. The preliminary results from each observation type will be introduced with the current development status of the KPOP.

  3. Have We Achieved a Unified Model of Photoreceptor Cell Fate Specification in Vertebrates?

    PubMed Central

    Raymond, Pamela A.

    2008-01-01

    How does a retinal progenitor choose to differentiate as a rod or a cone and, if it becomes a cone, which one of their different subtypes? The mechanisms of photoreceptor cell fate specification and differentiation have been extensively investigated in a variety of animal model systems, including human and non-human primates, rodents (mice and rats), chickens, frogs (Xenopus) and fish. It appears timely to discuss whether it is possible to synthesize the resulting information into a unified model applicable to all vertebrates. In this review we focus on several widely used experimental animal model systems to highlight differences in photoreceptor properties among species, the diversity of developmental strategies and solutions that vertebrates use to create retinas with photoreceptors that are adapted to the visual needs of their species, and the limitations of the methods currently available for the investigation of photoreceptor cell fate specification. Based on these considerations, we conclude that we are not yet ready to construct a unified model of photoreceptor cell fate specification in the developing vertebrate retina. PMID:17466954

  4. Unification of the general non-linear sigma model and the Virasoro master equation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boer, J. de; Halpern, M.B.

    1997-06-01

    The Virasoro master equation describes a large set of conformal field theories known as the affine-Virasoro constructions, in the operator algebra (affinie Lie algebra) of the WZW model, while the einstein equations of the general non-linear sigma model describe another large set of conformal field theories. This talk summarizes recent work which unifies these two sets of conformal field theories, together with a presumable large class of new conformal field theories. The basic idea is to consider spin-two operators of the form L{sub ij}{partial_derivative}x{sup i}{partial_derivative}x{sup j} in the background of a general sigma model. The requirement that these operators satisfymore » the Virasoro algebra leads to a set of equations called the unified Einstein-Virasoro master equation, in which the spin-two spacetime field L{sub ij} cuples to the usual spacetime fields of the sigma model. The one-loop form of this unified system is presented, and some of its algebraic and geometric properties are discussed.« less

  5. An LMI approach to design H(infinity) controllers for discrete-time nonlinear systems based on unified models.

    PubMed

    Liu, Meiqin; Zhang, Senlin

    2008-10-01

    A unified neural network model termed standard neural network model (SNNM) is advanced. Based on the robust L(2) gain (i.e. robust H(infinity) performance) analysis of the SNNM with external disturbances, a state-feedback control law is designed for the SNNM to stabilize the closed-loop system and eliminate the effect of external disturbances. The control design constraints are shown to be a set of linear matrix inequalities (LMIs) which can be easily solved by various convex optimization algorithms (e.g. interior-point algorithms) to determine the control law. Most discrete-time recurrent neural network (RNNs) and discrete-time nonlinear systems modelled by neural networks or Takagi and Sugeno (T-S) fuzzy models can be transformed into the SNNMs to be robust H(infinity) performance analyzed or robust H(infinity) controller synthesized in a unified SNNM's framework. Finally, some examples are presented to illustrate the wide application of the SNNMs to the nonlinear systems, and the proposed approach is compared with related methods reported in the literature.

  6. A unified tensor level set for image segmentation.

    PubMed

    Wang, Bin; Gao, Xinbo; Tao, Dacheng; Li, Xuelong

    2010-06-01

    This paper presents a new region-based unified tensor level set model for image segmentation. This model introduces a three-order tensor to comprehensively depict features of pixels, e.g., gray value and the local geometrical features, such as orientation and gradient, and then, by defining a weighted distance, we generalized the representative region-based level set method from scalar to tensor. The proposed model has four main advantages compared with the traditional representative method as follows. First, involving the Gaussian filter bank, the model is robust against noise, particularly the salt- and pepper-type noise. Second, considering the local geometrical features, e.g., orientation and gradient, the model pays more attention to boundaries and makes the evolving curve stop more easily at the boundary location. Third, due to the unified tensor pixel representation representing the pixels, the model segments images more accurately and naturally. Fourth, based on a weighted distance definition, the model possesses the capacity to cope with data varying from scalar to vector, then to high-order tensor. We apply the proposed method to synthetic, medical, and natural images, and the result suggests that the proposed method is superior to the available representative region-based level set method.

  7. Conceptualising paediatric health disparities: a metanarrative systematic review and unified conceptual framework.

    PubMed

    Ridgeway, Jennifer L; Wang, Zhen; Finney Rutten, Lila J; van Ryn, Michelle; Griffin, Joan M; Murad, M Hassan; Asiedu, Gladys B; Egginton, Jason S; Beebe, Timothy J

    2017-08-04

    There exists a paucity of work in the development and testing of theoretical models specific to childhood health disparities even though they have been linked to the prevalence of adult health disparities including high rates of chronic disease. We conducted a systematic review and thematic analysis of existing models of health disparities specific to children to inform development of a unified conceptual framework. We systematically reviewed articles reporting theoretical or explanatory models of disparities on a range of outcomes related to child health. We searched Ovid Medline In-Process & Other Non-Indexed Citations, Ovid MEDLINE, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus (database inception to 9 July 2015). A metanarrative approach guided the analysis process. A total of 48 studies presenting 48 models were included. This systematic review found multiple models but no consensus on one approach. However, we did discover a fair amount of overlap, such that the 48 models reviewed converged into the unified conceptual framework. The majority of models included factors in three domains: individual characteristics and behaviours (88%), healthcare providers and systems (63%), and environment/community (56%), . Only 38% of models included factors in the health and public policies domain. A disease-agnostic unified conceptual framework may inform integration of existing knowledge of child health disparities and guide future research. This multilevel framework can focus attention among clinical, basic and social science research on the relationships between policy, social factors, health systems and the physical environment that impact children's health outcomes. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  8. The coherence problem with th Unified Neutral Theory of biodiversity

    Treesearch

    James S. Clark

    2012-01-01

    The Unified Neutral Theory of Biodiversity (UNTB), proposed as an alternative to niche theory, has been viewed as a theory that species coexist without niche differences, without fitness differences, or with equal probability of success. Support is claimed when models lacking species differences predict highly aggregated metrics, such as species abundance distributions...

  9. The Unified Core: A "Major" Learning Community Model in Action

    ERIC Educational Resources Information Center

    Powell, Gwynn M.; Johnson, Corey W.; James, J. Joy; Dunlap, Rudy

    2011-01-01

    The Unified Core is an innovative approach to higher education that blends content through linked courses within a major to create a community of learners. This article offers the theoretical background for the approach, describes the implementation, and offers suggestions to educators who would like to design their own version of this innovative…

  10. The Impact of Investments in Additional Preparation on Unified State Exam Results

    ERIC Educational Resources Information Center

    Prakhov, Ilya Arkadyevich

    2015-01-01

    The paper proposes a model of educational strategies for college entrants that makes it possible to assess the investment efficiency in additional preparation as evidenced by the Unified State Exam [USE] scores. It was found that college entrants still use traditional forms of preparation despite the new institutional admission conditions at…

  11. Construction of Critically Transformative Education in the Tucson Unified School District

    ERIC Educational Resources Information Center

    Romero, Augustine F.; Sánchez, H. T.

    2014-01-01

    A critically transformative education continues to be at the center of Tucson Unified School District's (TUSD) equity and academic excellence mission. Through the use of the Social Transformation paradigm and the lesson learned from the implementation of the Critically Compassionate Intellectualism Model, TUSD once again created a cutting edge…

  12. In Search of the Unifying Principles of Psychotherapy: Conceptual, Empirical, and Clinical Convergence

    ERIC Educational Resources Information Center

    Magnavita, Jeffrey J.

    2006-01-01

    The search for the principles of unified psychotherapy is an important stage in the advancement of the field. Converging evidence from various streams of clinical science allows the identification of some of the major domains of human functioning, adaptation, and dysfunction. These principles, supported by animal modeling, neuroscience, and…

  13. Groundwater modelling in decision support: reflections on a unified conceptual framework

    NASA Astrophysics Data System (ADS)

    Doherty, John; Simmons, Craig T.

    2013-11-01

    Groundwater models are commonly used as basis for environmental decision-making. There has been discussion and debate in recent times regarding the issue of model simplicity and complexity. This paper contributes to this ongoing discourse. The selection of an appropriate level of model structural and parameterization complexity is not a simple matter. Although the metrics on which such selection should be based are simple, there are many competing, and often unquantifiable, considerations which must be taken into account as these metrics are applied. A unified conceptual framework is introduced and described which is intended to underpin groundwater modelling in decision support with a direct focus on matters regarding model simplicity and complexity.

  14. Pattern-oriented modeling of agent-based complex systems: Lessons from ecology

    USGS Publications Warehouse

    Grimm, Volker; Revilla, Eloy; Berger, Uta; Jeltsch, Florian; Mooij, Wolf M.; Railsback, Steven F.; Thulke, Hans-Hermann; Weiner, Jacob; Wiegand, Thorsten; DeAngelis, Donald L.

    2005-01-01

    Agent-based complex systems are dynamic networks of many interacting agents; examples include ecosystems, financial markets, and cities. The search for general principles underlying the internal organization of such systems often uses bottom-up simulation models such as cellular automata and agent-based models. No general framework for designing, testing, and analyzing bottom-up models has yet been established, but recent advances in ecological modeling have come together in a general strategy we call pattern-oriented modeling. This strategy provides a unifying framework for decoding the internal organization of agent-based complex systems and may lead toward unifying algorithmic theories of the relation between adaptive behavior and system complexity.

  15. Pattern-Oriented Modeling of Agent-Based Complex Systems: Lessons from Ecology

    NASA Astrophysics Data System (ADS)

    Grimm, Volker; Revilla, Eloy; Berger, Uta; Jeltsch, Florian; Mooij, Wolf M.; Railsback, Steven F.; Thulke, Hans-Hermann; Weiner, Jacob; Wiegand, Thorsten; DeAngelis, Donald L.

    2005-11-01

    Agent-based complex systems are dynamic networks of many interacting agents; examples include ecosystems, financial markets, and cities. The search for general principles underlying the internal organization of such systems often uses bottom-up simulation models such as cellular automata and agent-based models. No general framework for designing, testing, and analyzing bottom-up models has yet been established, but recent advances in ecological modeling have come together in a general strategy we call pattern-oriented modeling. This strategy provides a unifying framework for decoding the internal organization of agent-based complex systems and may lead toward unifying algorithmic theories of the relation between adaptive behavior and system complexity.

  16. User's manual for UCAP: Unified Counter-Rotation Aero-Acoustics Program

    NASA Technical Reports Server (NTRS)

    Culver, E. M.; Mccolgan, C. J.

    1993-01-01

    This is the user's manual for the Unified Counter-rotation Aeroacoustics Program (UCAP), the counter-rotation derivative of the UAAP (Unified Aero-Acoustic Program). The purpose of this program is to predict steady and unsteady air loading on the blades and the noise produced by a counter-rotation Prop-Fan. The aerodynamic method is based on linear potential theory with corrections for nonlinearity associated with axial flux induction, vortex lift on the blades, and rotor-to-rotor interference. The theory for acoustics and the theory for individual blade loading and wakes are derived in Unified Aeroacoustics Analysis for High Speed Turboprop Aerodynamics and Noise, Volume 1 (NASA CR-4329). This user's manual also includes a brief explanation of the theory used for the modelling of counter-rotation.

  17. User's manual for UCAP: Unified Counter-Rotation Aero-Acoustics Program

    NASA Astrophysics Data System (ADS)

    Culver, E. M.; McColgan, C. J.

    1993-04-01

    This is the user's manual for the Unified Counter-rotation Aeroacoustics Program (UCAP), the counter-rotation derivative of the UAAP (Unified Aero-Acoustic Program). The purpose of this program is to predict steady and unsteady air loading on the blades and the noise produced by a counter-rotation Prop-Fan. The aerodynamic method is based on linear potential theory with corrections for nonlinearity associated with axial flux induction, vortex lift on the blades, and rotor-to-rotor interference. The theory for acoustics and the theory for individual blade loading and wakes are derived in Unified Aeroacoustics Analysis for High Speed Turboprop Aerodynamics and Noise, Volume 1 (NASA CR-4329). This user's manual also includes a brief explanation of the theory used for the modelling of counter-rotation.

  18. New Constraints on the Unified Model of Seyfert Galaxies

    NASA Astrophysics Data System (ADS)

    Maiolino, R.; Ruiz, M.; Rieke, G. H.; Keller, L. D.

    1995-06-01

    We present new 10 microns (N-band) photometry for 70 Seyfert galaxies, 43 of them previously unobserved. These observations, together with those collected from the literature, complete the 10 microns photometry for the CfA Sy galaxies and cover 80% of the Sy found in the RSA and 70% of the Sy in the IRAS 12 microns sample. From this data set, we find that Sy not showing any evidence for broad lines are systematically weaker in 10 microns nuclear emission than Sy nuclei having broad lines. This result may indicate the existence of a group of very low-luminosity Sy2 galaxies that do not have Sy1 counterparts in equal numbers, contrary to the strict unified theory. Alternately, the result can be reconciled with unified theories if a specific type of geometry is assumed for the circumnuclear obscuring material. By comparing the 10 microns ground-based observations with the IRAS 12 microns fluxes, we also study the properties of the extended mid-IR emission, i.e., the star forming activity of the host galaxy of the Sy nucleus. We find Sy2 to lie preferentially in galaxies experiencing enhanced star-forming activity, while Sy1 lie in normal or quiescent galaxies. This result appears to be inconsistent with the strict unified model, since the host galaxy properties should be independent of the orientation of a circumnuclear torus and therefore should be independent of nuclear type. Our finding could be explained by adding to the unified model a link between star-forming activity and the amount of obscuring material collected in the circumnuclear region.

  19. Imaging of 2-D multichannel land seismic data using an iterative inversion-migration scheme, Naga Thrust and Fold Belt, Assam, India

    NASA Astrophysics Data System (ADS)

    Jaiswal, Priyank; Dasgupta, Rahul

    2010-05-01

    We demonstrate that imaging of 2-D multichannel land seismic data can be effectively accomplished by a combination of reflection traveltime tomography and pre-stack depth migration (PSDM); we refer to the combined process as "the unified imaging". The unified imaging comprises cyclic runs of joint reflection and direct arrival inversion and pre-stack depth migration. From one cycle to another, both the inversion and the migration provide mutual feedbacks that are guided by the geological interpretation. The unified imaging is implemented in two broad stages. The first stage is similar to the conventional imaging except that it involves a significant use of velocity model from the inversion of the direct arrivals for both datuming and stacking velocity analysis. The first stage ends with an initial interval velocity model (from the stacking velocity analysis) and a corresponding depth migrated image. The second stage updates the velocity model and the depth image from the first stage in a cyclic manner; a single cycle comprises a single run of reflection traveltime inversion followed by PSDM. Interfaces used in the inversion are interpretations of the PSDM image in the previous cycle and the velocity model used in PSDM is from the joint inversion in the current cycle. Additionally in every cycle interpreted horizons in the stacked data are inverted as zero-offset reflections for constraining the interfaces; the velocity model is maintained stationary for the zero-offset inversion. A congruency factor, j, which measures the discrepancy between interfaces from the interpretation of the PSDM image and their corresponding counterparts from the inversion of the zero-offset reflections within assigned uncertainties, is computed in every cycle. A value of unity for jindicates that images from both the inversion and the migration are equivalent; at this point the unified imaging is said to have converged and is halted. We apply the unified imaging to 2-D multichannel seismic data from the Naga Thrust and Fold Belt (NTFB), India, were several exploratory wells in the last decade targeting sub-thrust leads in the footwall have failed. This failure is speculatively due to incorrect depth images which are in turn attributed to incorrect velocity models that are developed using conventional methods. The 2-D seismic data in this study is acquired perpendicular to the trend of the NTFB where the outcropping hanging wall has a topographic culmination. The acquisition style is split-spread with 30 m shot and receiver spacing and a nominal fold of 90. The data are recorded with a sample interval of 2 ms. Overall the data have a moderate signal-to-noise ratio and a broad frequency bandwidth of 8-80 Hz. The seismic line contains the failed exploratory well in the central part. The final results from unified imaging (both the depth image and the corresponding velocity model) suggest presence of a triangle zone, which was previously undiscovered. Conventional imaging had falsely portrayed the triangle zone as structural high which was interpreted as an anticline. As a result, the exploratory well, meant to target the anticline, met with pressure changes which were neither expected nor explained. The unified imaging results not only explain the observations in the well but also reveal new leads in the region. The velocity model from unified imaging was also found to be adequate for frequency-domain full-waveform imaging of the hanging wall. Results from waveform inversion are further corroborated by the geological interpretation of the exploratory well.

  20. A weak AMOC in a cold climate: Causes and remedies for a bias in the low-resolution version of the UK Earth System Model

    NASA Astrophysics Data System (ADS)

    Kuhlbrodt, T.; Jones, C.

    2016-02-01

    The UK Earth System Model (UKESM) is currently being developed by the UK Met Office and the academic community in the UK. The low-resolution version of UKESM has got a nominal grid cell size of 150 km in the atmosphere (Unified Model [UM], N96) and 1° in the ocean (NEMO, ORCA1). In several preliminary test configurations of UKESM-N96-ORCA1, we find a significant cold bias in the northern hemisphere in comparison with HadGEM2 (N96-ORCA025, i.e. 0.25° resolution in the ocean). The sea surface is too cold by more than 2 K, and up to 6 K, in large parts of the North Atlantic and the northwest Pacific. In addition to the cold bias, the maximum AMOC transport (diagnosed below 500 m depth) decreases in all the configurations, displaying values between 11 and 14 Sv after 50 years run length. Transport at 26°N is even smaller and hence too weak in relation to observed values (approx. 18 Sv). The mixed layer is too deep within the North Atlantic Current and the Kuroshio, but too shallow north of these currents. The cold bias extends to a depth of several hundred metres. In the North Atlantic, it is accompanied by a freshening of up to 1.5 psu, compared to present-day climatology, along the path of the North Atlantic Current. A core problem appears to be the cessation of deep-water formation in the Labrador Sea. Remarkably, using earlier versions of NEMO and the UM, the AMOC is stable at around 16 or 17 Sv in the N96-ORCA1 configuration. We report on various strategies to reduce the cold bias and enhance the AMOC transport. Changing various parameters that affect the vertical mixing in NEMO has no significant effect. Modifying the bathymetry to deepen and widen the channels across the Greenland-Iceland-Scotland sill leads to a short-term improvement in AMOC transport, but only for about ten years. Strikingly, in a configuration with longer time steps for the atmosphere model we find a climate that is even colder, but has got a more vigorous maximum AMOC transport (14 Sv instead of 12 Sv). Conversely, if the isopycnal diffusivity is augmented by a factor of 1.5, we find a warming and an even weaker AMOC transport. This brings us to further strategies to modify the atmosphere-ocean fluxes of heat and freshwater.

  1. Unified Static and Dynamic Recrystallization Model for the Minerals of Earth's Mantle Using Internal State Variable Model

    NASA Astrophysics Data System (ADS)

    Cho, H. E.; Horstemeyer, M. F.; Baumgardner, J. R.

    2017-12-01

    In this study, we present an internal state variable (ISV) constitutive model developed to model static and dynamic recrystallization and grain size progression in a unified manner. This method accurately captures temperature, pressure and strain rate effect on the recrystallization and grain size. Because this ISV approach treats dislocation density, volume fraction of recrystallization and grain size as internal variables, this model can simultaneously track their history during the deformation with unprecedented realism. Based on this deformation history, this method can capture realistic mechanical properties such as stress-strain behavior in the relationship of microstructure-mechanical property. Also, both the transient grain size during the deformation and the steady-state grain size of dynamic recrystallization can be predicted from the history variable of recrystallization volume fraction. Furthermore, because this model has a capability to simultaneously handle plasticity and creep behaviors (unified creep-plasticity), the mechanisms (static recovery (or diffusion creep), dynamic recovery (or dislocation creep) and hardening) related to dislocation dynamics can also be captured. To model these comprehensive mechanical behaviors, the mathematical formulation of this model includes elasticity to evaluate yield stress, work hardening in treating plasticity, creep, as well as the unified recrystallization and grain size progression. Because pressure sensitivity is especially important for the mantle minerals, we developed a yield function combining Drucker-Prager shear failure and von Mises yield surfaces to model the pressure dependent yield stress, while using pressure dependent work hardening and creep terms. Using these formulations, we calibrated against experimental data of the minerals acquired from the literature. Additionally, we also calibrated experimental data for metals to show the general applicability of our model. Understanding of realistic mantle dynamics can only be acquired once the various deformation regimes and mechanisms are comprehensively modeled. The results of this study demonstrate that this ISV model is a good modeling candidate to help reveal the realistic dynamics of the Earth's mantle.

  2. A unified analytical drain current model for Double-Gate Junctionless Field-Effect Transistors including short channel effects

    NASA Astrophysics Data System (ADS)

    Raksharam; Dutta, Aloke K.

    2017-04-01

    In this paper, a unified analytical model for the drain current of a symmetric Double-Gate Junctionless Field-Effect Transistor (DG-JLFET) is presented. The operation of the device has been classified into four modes: subthreshold, semi-depleted, accumulation, and hybrid; with the main focus of this work being on the accumulation mode, which has not been dealt with in detail so far in the literature. A physics-based model, using a simplified one-dimensional approach, has been developed for this mode, and it has been successfully integrated with the model for the hybrid mode. It also includes the effect of carrier mobility degradation due to the transverse electric field, which was hitherto missing in the earlier models reported in the literature. The piece-wise models have been unified using suitable interpolation functions. In addition, the model includes two most important short-channel effects pertaining to DG-JLFETs, namely the Drain Induced Barrier Lowering (DIBL) and the Subthreshold Swing (SS) degradation. The model is completely analytical, and is thus computationally highly efficient. The results of our model have shown an excellent match with those obtained from TCAD simulations for both long- and short-channel devices, as well as with the experimental data reported in the literature.

  3. An Empirical Analysis of Citizens' Acceptance Decisions of Electronic-Government Services: A Modification of the Unified Theory of Acceptance and Use of Technology (UTAUT) Model to Include Trust as a Basis for Investigation

    ERIC Educational Resources Information Center

    Awuah, Lawrence J.

    2012-01-01

    Understanding citizens' adoption of electronic-government (e-government) is an important topic, as the use of e-government has become an integral part of governance. Success of such initiatives depends largely on the efficient use of e-government services. The unified theory of acceptance and use of technology (UTAUT) model has provided a…

  4. Unified formalism for higher order non-autonomous dynamical systems

    NASA Astrophysics Data System (ADS)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2012-03-01

    This work is devoted to giving a geometric framework for describing higher order non-autonomous mechanical systems. The starting point is to extend the Lagrangian-Hamiltonian unified formalism of Skinner and Rusk for these kinds of systems, generalizing previous developments for higher order autonomous mechanical systems and first-order non-autonomous mechanical systems. Then, we use this unified formulation to derive the standard Lagrangian and Hamiltonian formalisms, including the Legendre-Ostrogradsky map and the Euler-Lagrange and the Hamilton equations, both for regular and singular systems. As applications of our model, two examples of regular and singular physical systems are studied.

  5. Research and development activities in unified control-structure modeling and design

    NASA Technical Reports Server (NTRS)

    Nayak, A. P.

    1985-01-01

    Results of work to develop a unified control/structures modeling and design capability for large space structures modeling are presented. Recent analytical results are presented to demonstrate the significant interdependence between structural and control properties. A new design methodology is suggested in which the structure, material properties, dynamic model and control design are all optimized simultaneously. Parallel research done by other researchers is reviewed. The development of a methodology for global design optimization is recommended as a long-term goal. It is suggested that this methodology should be incorporated into computer aided engineering programs, which eventually will be supplemented by an expert system to aid design optimization.

  6. SSBRP Communication & Data System Development using the Unified Modeling Language (UML)

    NASA Technical Reports Server (NTRS)

    Windrem, May; Picinich, Lou; Givens, John J. (Technical Monitor)

    1998-01-01

    The Unified Modeling Language (UML) is the standard method for specifying, visualizing, and documenting the artifacts of an object-oriented system under development. UML is the unification of the object-oriented methods developed by Grady Booch and James Rumbaugh, and of the Use Case Model developed by Ivar Jacobson. This paper discusses the application of UML by the Communications and Data Systems (CDS) team to model the ground control and command of the Space Station Biological Research Project (SSBRP) User Operations Facility (UOF). UML is used to define the context of the system, the logical static structure, the life history of objects, and the interactions among objects.

  7. A unified physical model of Seebeck coefficient in amorphous oxide semiconductor thin-film transistors

    NASA Astrophysics Data System (ADS)

    Lu, Nianduan; Li, Ling; Sun, Pengxiao; Banerjee, Writam; Liu, Ming

    2014-09-01

    A unified physical model for Seebeck coefficient was presented based on the multiple-trapping and release theory for amorphous oxide semiconductor thin-film transistors. According to the proposed model, the Seebeck coefficient is attributed to the Fermi-Dirac statistics combined with the energy dependent trap density of states and the gate-voltage dependence of the quasi-Fermi level. The simulation results show that the gate voltage, energy disorder, and temperature dependent Seebeck coefficient can be well described. The calculation also shows a good agreement with the experimental data in amorphous In-Ga-Zn-O thin-film transistor.

  8. Unified Viscoplastic Behavior of Metal Matrix Composites

    NASA Technical Reports Server (NTRS)

    Arnold, S. M.; Robinson, D. N.; Bartolotta, P. A.

    1992-01-01

    The need for unified constitutive models was recognized more than a decade ago in the results of phenomenological tests on monolithic metals that exhibited strong creep-plasticity interaction. Recently, metallic alloys have been combined to form high-temperature ductile/ductile composite materials, raising the natural question of whether these metallic composites exhibit the same phenomenological features as their monolithic constituents. This question is addressed in the context of a limited, yet definite (to illustrate creep/plasticity interaction) set of experimental data on the model metal matrix composite (MMC) system W/Kanthal. Furthermore, it is demonstrated that a unified viscoplastic representation, extended for unidirectional composites and correlated to W/Kanthal, can accurately predict the observed longitudinal composite creep/plasticity interaction response and strain rate dependency. Finally, the predicted influence of fiber orientation on the creep response of W/Kanthal is illustrated.

  9. Four Courses within a Discipline: UGA Unified Core

    ERIC Educational Resources Information Center

    Powell, Gwynn M.; Johnson, Corey W.; James, Joy; Dunlap, Rudy

    2013-01-01

    This article introduces the reader to the Unified Core Curriculum model developed and implemented at the University of Georgia (UGA). Four courses are taught as one course to the juniors coming into the Recreation and Leisure Studies major. An overview of the blended course and sample assignments are provided, as well as a discussion of challenges…

  10. Psychometric evaluation of a unified Portuguese-language version of the Body Shape Questionnaire in female university students.

    PubMed

    Silva, Wanderson Roberto; Costa, David; Pimenta, Filipa; Maroco, João; Campos, Juliana Alvares Duarte Bonini

    2016-07-21

    The objectives of this study were to develop a unified Portuguese-language version, for use in Brazil and Portugal, of the Body Shape Questionnaire (BSQ) and to estimate its validity, reliability, and internal consistency in Brazilian and Portuguese female university students. Confirmatory factor analysis was performed using both original (34-item) and shortened (8-item) versions. The model's fit was assessed with χ²/df, CFI, NFI, and RMSEA. Concurrent and convergent validity were assessed. Reliability was estimated through internal consistency and composite reliability (α). Transnational invariance of the BSQ was tested using multi-group analysis. The original 32-item model was refined to present a better fit and adequate validity and reliability. The shortened model was stable in both independent samples and in transnational samples (Brazil and Portugal). The use of this unified version is recommended for the assessment of body shape concerns in both Brazilian and Portuguese college students.

  11. A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Peyret, Thomas; Poulin, Patrick; Krishnan, Kannan, E-mail: kannan.krishnan@umontreal.ca

    The algorithms in the literature focusing to predict tissue:blood PC (P{sub tb}) for environmental chemicals and tissue:plasma PC based on total (K{sub p}) or unbound concentration (K{sub pu}) for drugs differ in their consideration of binding to hemoglobin, plasma proteins and charged phospholipids. The objective of the present study was to develop a unified algorithm such that P{sub tb}, K{sub p} and K{sub pu} for both drugs and environmental chemicals could be predicted. The development of the unified algorithm was accomplished by integrating all mechanistic algorithms previously published to compute the PCs. Furthermore, the algorithm was structured in such amore » way as to facilitate predictions of the distribution of organic compounds at the macro (i.e. whole tissue) and micro (i.e. cells and fluids) levels. The resulting unified algorithm was applied to compute the rat P{sub tb}, K{sub p} or K{sub pu} of muscle (n = 174), liver (n = 139) and adipose tissue (n = 141) for acidic, neutral, zwitterionic and basic drugs as well as ketones, acetate esters, alcohols, aliphatic hydrocarbons, aromatic hydrocarbons and ethers. The unified algorithm reproduced adequately the values predicted previously by the published algorithms for a total of 142 drugs and chemicals. The sensitivity analysis demonstrated the relative importance of the various compound properties reflective of specific mechanistic determinants relevant to prediction of PC values of drugs and environmental chemicals. Overall, the present unified algorithm uniquely facilitates the computation of macro and micro level PCs for developing organ and cellular-level PBPK models for both chemicals and drugs.« less

  12. Construction of multi-functional open modulized Matlab simulation toolbox for imaging ladar system

    NASA Astrophysics Data System (ADS)

    Wu, Long; Zhao, Yuan; Tang, Meng; He, Jiang; Zhang, Yong

    2011-06-01

    Ladar system simulation is to simulate the ladar models using computer simulation technology in order to predict the performance of the ladar system. This paper presents the developments of laser imaging radar simulation for domestic and overseas studies and the studies of computer simulation on ladar system with different application requests. The LadarSim and FOI-LadarSIM simulation facilities of Utah State University and Swedish Defence Research Agency are introduced in details. This paper presents the low level of simulation scale, un-unified design and applications of domestic researches in imaging ladar system simulation, which are mostly to achieve simple function simulation based on ranging equations for ladar systems. Design of laser imaging radar simulation with open and modularized structure is proposed to design unified modules for ladar system, laser emitter, atmosphere models, target models, signal receiver, parameters setting and system controller. Unified Matlab toolbox and standard control modules have been built with regulated input and output of the functions, and the communication protocols between hardware modules. A simulation based on ICCD gain-modulated imaging ladar system for a space shuttle is made based on the toolbox. The simulation result shows that the models and parameter settings of the Matlab toolbox are able to simulate the actual detection process precisely. The unified control module and pre-defined parameter settings simplify the simulation of imaging ladar detection. Its open structures enable the toolbox to be modified for specialized requests. The modulization gives simulations flexibility.

  13. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma

    PubMed Central

    Landreville, Solange; Agapova, Olga A.; Matatall, Katie A.; Kneass, Zachary T.; Onken, Michael D.; Lee, Ryan S.; Bowcock, Anne M.; Harbour, J. William

    2011-01-01

    Purpose Metastasis is responsible for the death of most cancer patients, yet few therapeutic agents are available which specifically target the molecular events that lead to metastasis. We recently showed that inactivating mutations in the tumor suppressor gene BAP1 are closely associated with loss of melanocytic differentiation in uveal melanoma and metastasis (UM). The purpose of this study was to identify therapeutic agents that reverse the phenotypic effects of BAP1 loss in UM. Experimental Design In silico screens were performed to identify therapeutic compounds predicted to differentiate UM cells using Gene Set Enrichment Analysis and Connectivity Map databases. Valproic acid, trichostatin A, LBH-589 and suberoylanilide hydroxamic acid were evaluated for their effects on UM cells using morphologic evaluation, MTS viability assays, BrdU incorporation, flow cytometry, clonogenic assays, gene expression profiling, histone acetylation and ubiquitination assays, and a murine xenograft tumorigenicity model. Results HDAC inhibitors induced morphologic differentiation, cell cycle exit, and a shift to a differentiated, melanocytic gene expression profile in cultured UM cells. Valproic acid inhibited the growth of UM tumors in vivo. Conclusions These findings suggest that HDAC inhibitors may have therapeutic potential for inducing differentiation and prolonged dormancy of micrometastatic disease in UM. PMID:22038994

  14. OmniPHR: A distributed architecture model to integrate personal health records.

    PubMed

    Roehrs, Alex; da Costa, Cristiano André; da Rosa Righi, Rodrigo

    2017-07-01

    The advances in the Information and Communications Technology (ICT) brought many benefits to the healthcare area, specially to digital storage of patients' health records. However, it is still a challenge to have a unified viewpoint of patients' health history, because typically health data is scattered among different health organizations. Furthermore, there are several standards for these records, some of them open and others proprietary. Usually health records are stored in databases within health organizations and rarely have external access. This situation applies mainly to cases where patients' data are maintained by healthcare providers, known as EHRs (Electronic Health Records). In case of PHRs (Personal Health Records), in which patients by definition can manage their health records, they usually have no control over their data stored in healthcare providers' databases. Thereby, we envision two main challenges regarding PHR context: first, how patients could have a unified view of their scattered health records, and second, how healthcare providers can access up-to-date data regarding their patients, even though changes occurred elsewhere. For addressing these issues, this work proposes a model named OmniPHR, a distributed model to integrate PHRs, for patients and healthcare providers use. The scientific contribution is to propose an architecture model to support a distributed PHR, where patients can maintain their health history in an unified viewpoint, from any device anywhere. Likewise, for healthcare providers, the possibility of having their patients data interconnected among health organizations. The evaluation demonstrates the feasibility of the model in maintaining health records distributed in an architecture model that promotes a unified view of PHR with elasticity and scalability of the solution. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. A Unified Model of Performance: Validation of its Predictions across Different Sleep/Wake Schedules

    PubMed Central

    Ramakrishnan, Sridhar; Wesensten, Nancy J.; Balkin, Thomas J.; Reifman, Jaques

    2016-01-01

    Study Objectives: Historically, mathematical models of human neurobehavioral performance developed on data from one sleep study were limited to predicting performance in similar studies, restricting their practical utility. We recently developed a unified model of performance (UMP) to predict the effects of the continuum of sleep loss—from chronic sleep restriction (CSR) to total sleep deprivation (TSD) challenges—and validated it using data from two studies of one laboratory. Here, we significantly extended this effort by validating the UMP predictions across a wide range of sleep/wake schedules from different studies and laboratories. Methods: We developed the UMP on psychomotor vigilance task (PVT) lapse data from one study encompassing four different CSR conditions (7 d of 3, 5, 7, and 9 h of sleep/night), and predicted performance in five other studies (from four laboratories), including different combinations of TSD (40 to 88 h), CSR (2 to 6 h of sleep/night), control (8 to 10 h of sleep/night), and nap (nocturnal and diurnal) schedules. Results: The UMP accurately predicted PVT performance trends across 14 different sleep/wake conditions, yielding average prediction errors between 7% and 36%, with the predictions lying within 2 standard errors of the measured data 87% of the time. In addition, the UMP accurately predicted performance impairment (average error of 15%) for schedules (TSD and naps) not used in model development. Conclusions: The unified model of performance can be used as a tool to help design sleep/wake schedules to optimize the extent and duration of neurobehavioral performance and to accelerate recovery after sleep loss. Citation: Ramakrishnan S, Wesensten NJ, Balkin TJ, Reifman J. A unified model of performance: validation of its predictions across different sleep/wake schedules. SLEEP 2016;39(1):249–262. PMID:26518594

  16. A Unified Model of Performance for Predicting the Effects of Sleep and Caffeine

    PubMed Central

    Ramakrishnan, Sridhar; Wesensten, Nancy J.; Kamimori, Gary H.; Moon, James E.; Balkin, Thomas J.; Reifman, Jaques

    2016-01-01

    Study Objectives: Existing mathematical models of neurobehavioral performance cannot predict the beneficial effects of caffeine across the spectrum of sleep loss conditions, limiting their practical utility. Here, we closed this research gap by integrating a model of caffeine effects with the recently validated unified model of performance (UMP) into a single, unified modeling framework. We then assessed the accuracy of this new UMP in predicting performance across multiple studies. Methods: We hypothesized that the pharmacodynamics of caffeine vary similarly during both wakefulness and sleep, and that caffeine has a multiplicative effect on performance. Accordingly, to represent the effects of caffeine in the UMP, we multiplied a dose-dependent caffeine factor (which accounts for the pharmacokinetics and pharmacodynamics of caffeine) to the performance estimated in the absence of caffeine. We assessed the UMP predictions in 14 distinct laboratory- and field-study conditions, including 7 different sleep-loss schedules (from 5 h of sleep per night to continuous sleep loss for 85 h) and 6 different caffeine doses (from placebo to repeated 200 mg doses to a single dose of 600 mg). Results: The UMP accurately predicted group-average psychomotor vigilance task performance data across the different sleep loss and caffeine conditions (6% < error < 27%), yielding greater accuracy for mild and moderate sleep loss conditions than for more severe cases. Overall, accounting for the effects of caffeine resulted in improved predictions (after caffeine consumption) by up to 70%. Conclusions: The UMP provides the first comprehensive tool for accurate selection of combinations of sleep schedules and caffeine countermeasure strategies to optimize neurobehavioral performance. Citation: Ramakrishnan S, Wesensten NJ, Kamimori GH, Moon JE, Balkin TJ, Reifman J. A unified model of performance for predicting the effects of sleep and caffeine. SLEEP 2016;39(10):1827–1841. PMID:27397562

  17. Generalized Information Theory Meets Human Cognition: Introducing a Unified Framework to Model Uncertainty and Information Search.

    PubMed

    Crupi, Vincenzo; Nelson, Jonathan D; Meder, Björn; Cevolani, Gustavo; Tentori, Katya

    2018-06-17

    Searching for information is critical in many situations. In medicine, for instance, careful choice of a diagnostic test can help narrow down the range of plausible diseases that the patient might have. In a probabilistic framework, test selection is often modeled by assuming that people's goal is to reduce uncertainty about possible states of the world. In cognitive science, psychology, and medical decision making, Shannon entropy is the most prominent and most widely used model to formalize probabilistic uncertainty and the reduction thereof. However, a variety of alternative entropy metrics (Hartley, Quadratic, Tsallis, Rényi, and more) are popular in the social and the natural sciences, computer science, and philosophy of science. Particular entropy measures have been predominant in particular research areas, and it is often an open issue whether these divergences emerge from different theoretical and practical goals or are merely due to historical accident. Cutting across disciplinary boundaries, we show that several entropy and entropy reduction measures arise as special cases in a unified formalism, the Sharma-Mittal framework. Using mathematical results, computer simulations, and analyses of published behavioral data, we discuss four key questions: How do various entropy models relate to each other? What insights can be obtained by considering diverse entropy models within a unified framework? What is the psychological plausibility of different entropy models? What new questions and insights for research on human information acquisition follow? Our work provides several new pathways for theoretical and empirical research, reconciling apparently conflicting approaches and empirical findings within a comprehensive and unified information-theoretic formalism. Copyright © 2018 Cognitive Science Society, Inc.

  18. A unified model for transfer alignment at random misalignment angles based on second-order EKF

    NASA Astrophysics Data System (ADS)

    Cui, Xiao; Mei, Chunbo; Qin, Yongyuan; Yan, Gongmin; Liu, Zhenbo

    2017-04-01

    In the transfer alignment process of inertial navigation systems (INSs), the conventional linear error model based on the small misalignment angle assumption cannot be applied to large misalignment situations. Furthermore, the nonlinear model based on the large misalignment angle suffers from redundant computation with nonlinear filters. This paper presents a unified model for transfer alignment suitable for arbitrary misalignment angles. The alignment problem is transformed into an estimation of the relative attitude between the master INS (MINS) and the slave INS (SINS), by decomposing the attitude matrix of the latter. Based on the Rodriguez parameters, a unified alignment model in the inertial frame with the linear state-space equation and a second order nonlinear measurement equation are established, without making any assumptions about the misalignment angles. Furthermore, we employ the Taylor series expansions on the second-order nonlinear measurement equation to implement the second-order extended Kalman filter (EKF2). Monte-Carlo simulations demonstrate that the initial alignment can be fulfilled within 10 s, with higher accuracy and much smaller computational cost compared with the traditional unscented Kalman filter (UKF) at large misalignment angles.

  19. Factors Affecting Acceptance & Use of ReWIND: Validating the Extended Unified Theory of Acceptance and Use of Technology

    ERIC Educational Resources Information Center

    Nair, Pradeep Kumar; Ali, Faizan; Leong, Lim Chee

    2015-01-01

    Purpose: This study aims to explain the factors affecting students' acceptance and usage of a lecture capture system (LCS)--ReWIND--in a Malaysian university based on the extended unified theory of acceptance and use of technology (UTAUT2) model. Technological advances have become an important feature of universities' plans to improve the…

  20. Laminar Cortical Dynamics of Cognitive and Motor Working Memory, Sequence Learning and Performance: Toward a Unified Theory of How the Cerebral Cortex Works

    ERIC Educational Resources Information Center

    Grossberg, Stephen; Pearson, Lance R.

    2008-01-01

    How does the brain carry out working memory storage, categorization, and voluntary performance of event sequences? The LIST PARSE neural model proposes an answer that unifies the explanation of cognitive, neurophysiological, and anatomical data. It quantitatively simulates human cognitive data about immediate serial recall and free recall, and…

  1. Modeling stroke rehabilitation processes using the Unified Modeling Language (UML).

    PubMed

    Ferrante, Simona; Bonacina, Stefano; Pinciroli, Francesco

    2013-10-01

    In organising and providing rehabilitation procedures for stroke patients, the usual need for many refinements makes it inappropriate to attempt rigid standardisation, but greater detail is required concerning workflow. The aim of this study was to build a model of the post-stroke rehabilitation process. The model, implemented in the Unified Modeling Language, was grounded on international guidelines and refined following the clinical pathway adopted at local level by a specialized rehabilitation centre. The model describes the organisation of the rehabilitation delivery and it facilitates the monitoring of recovery during the process. Indeed, a system software was developed and tested to support clinicians in the digital administration of clinical scales. The model flexibility assures easy updating after process evolution. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Development and application of unified algorithms for problems in computational science

    NASA Technical Reports Server (NTRS)

    Shankar, Vijaya; Chakravarthy, Sukumar

    1987-01-01

    A framework is presented for developing computationally unified numerical algorithms for solving nonlinear equations that arise in modeling various problems in mathematical physics. The concept of computational unification is an attempt to encompass efficient solution procedures for computing various nonlinear phenomena that may occur in a given problem. For example, in Computational Fluid Dynamics (CFD), a unified algorithm will be one that allows for solutions to subsonic (elliptic), transonic (mixed elliptic-hyperbolic), and supersonic (hyperbolic) flows for both steady and unsteady problems. The objectives are: development of superior unified algorithms emphasizing accuracy and efficiency aspects; development of codes based on selected algorithms leading to validation; application of mature codes to realistic problems; and extension/application of CFD-based algorithms to problems in other areas of mathematical physics. The ultimate objective is to achieve integration of multidisciplinary technologies to enhance synergism in the design process through computational simulation. Specific unified algorithms for a hierarchy of gas dynamics equations and their applications to two other areas: electromagnetic scattering, and laser-materials interaction accounting for melting.

  3. Lagrangian-Hamiltonian unified formalism for autonomous higher order dynamical systems

    NASA Astrophysics Data System (ADS)

    Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso

    2011-09-01

    The Lagrangian-Hamiltonian unified formalism of Skinner and Rusk was originally stated for autonomous dynamical systems in classical mechanics. It has been generalized for non-autonomous first-order mechanical systems, as well as for first-order and higher order field theories. However, a complete generalization to higher order mechanical systems is yet to be described. In this work, after reviewing the natural geometrical setting and the Lagrangian and Hamiltonian formalisms for higher order autonomous mechanical systems, we develop a complete generalization of the Lagrangian-Hamiltonian unified formalism for these kinds of systems, and we use it to analyze some physical models from this new point of view.

  4. A UML model for the description of different brain-computer interface systems.

    PubMed

    Quitadamo, Lucia Rita; Abbafati, Manuel; Saggio, Giovanni; Marciani, Maria Grazia; Cardarilli, Gian Carlo; Bianchi, Luigi

    2008-01-01

    BCI research lacks a universal descriptive language among labs and a unique standard model for the description of BCI systems. This results in a serious problem in comparing performances of different BCI processes and in unifying tools and resources. In such a view we implemented a Unified Modeling Language (UML) model for the description virtually of any BCI protocol and we demonstrated that it can be successfully applied to the most common ones such as P300, mu-rhythms, SCP, SSVEP, fMRI. Finally we illustrated the advantages in utilizing a standard terminology for BCIs and how the same basic structure can be successfully adopted for the implementation of new systems.

  5. Unified reduction principle for the evolution of mutation, migration, and recombination

    PubMed Central

    Altenberg, Lee; Liberman, Uri; Feldman, Marcus W.

    2017-01-01

    Modifier-gene models for the evolution of genetic information transmission between generations of organisms exhibit the reduction principle: Selection favors reduction in the rate of variation production in populations near equilibrium under a balance of constant viability selection and variation production. Whereas this outcome has been proven for a variety of genetic models, it has not been proven in general for multiallelic genetic models of mutation, migration, and recombination modification with arbitrary linkage between the modifier and major genes under viability selection. We show that the reduction principle holds for all of these cases by developing a unifying mathematical framework that characterizes all of these evolutionary models. PMID:28265103

  6. The impact of changing the land surface scheme in ACCESS(v1.0/1.1) on the surface climatology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kowalczyk, Eva A.; Stevens, Lauren E.; Law, Rachel M.

    The Community Atmosphere Biosphere Land Exchange (CABLE) model has been coupled to the UK Met Office Unified Model (UM) within the existing framework of the Australian Community Climate and Earth System Simulator (ACCESS), replacing the Met Office Surface Exchange Scheme (MOSES). Here we investigate how features of the CABLE model impact on present-day surface climate using ACCESS atmosphere-only simulations. The main differences attributed to CABLE include a warmer winter and a cooler summer in the Northern Hemisphere (NH), earlier NH spring runoff from snowmelt, and smaller seasonal and diurnal temperature ranges. The cooler NH summer temperatures in canopy-covered regions aremore » more consistent with observations and are attributed to two factors. Firstly, CABLE accounts for aerodynamic and radiative interactions between the canopy and the ground below; this placement of the canopy above the ground eliminates the need for a separate bare ground tile in canopy-covered areas. Secondly, CABLE simulates larger evapotranspiration fluxes and a slightly larger daytime cloud cover fraction. Warmer NH winter temperatures result from the parameterization of cold climate processes in CABLE in snow-covered areas. In particular, prognostic snow density increases through the winter and lowers the diurnally resolved snow albedo; variable snow thermal conductivity prevents early winter heat loss but allows more heat to enter the ground as the snow season progresses; liquid precipitation freezing within the snowpack delays the building of the snowpack in autumn and accelerates snow melting in spring. Altogether we find that the ACCESS simulation of surface air temperature benefits from the specific representation of the turbulent transport within and just above the canopy in the roughness sublayer as well as the more complex snow scheme in CABLE relative to MOSES.« less

  7. The impact of changing the land surface scheme in ACCESS(v1.0/1.1) on the surface climatology

    DOE PAGES

    Kowalczyk, Eva A.; Stevens, Lauren E.; Law, Rachel M.; ...

    2016-08-23

    The Community Atmosphere Biosphere Land Exchange (CABLE) model has been coupled to the UK Met Office Unified Model (UM) within the existing framework of the Australian Community Climate and Earth System Simulator (ACCESS), replacing the Met Office Surface Exchange Scheme (MOSES). Here we investigate how features of the CABLE model impact on present-day surface climate using ACCESS atmosphere-only simulations. The main differences attributed to CABLE include a warmer winter and a cooler summer in the Northern Hemisphere (NH), earlier NH spring runoff from snowmelt, and smaller seasonal and diurnal temperature ranges. The cooler NH summer temperatures in canopy-covered regions aremore » more consistent with observations and are attributed to two factors. Firstly, CABLE accounts for aerodynamic and radiative interactions between the canopy and the ground below; this placement of the canopy above the ground eliminates the need for a separate bare ground tile in canopy-covered areas. Secondly, CABLE simulates larger evapotranspiration fluxes and a slightly larger daytime cloud cover fraction. Warmer NH winter temperatures result from the parameterization of cold climate processes in CABLE in snow-covered areas. In particular, prognostic snow density increases through the winter and lowers the diurnally resolved snow albedo; variable snow thermal conductivity prevents early winter heat loss but allows more heat to enter the ground as the snow season progresses; liquid precipitation freezing within the snowpack delays the building of the snowpack in autumn and accelerates snow melting in spring. Altogether we find that the ACCESS simulation of surface air temperature benefits from the specific representation of the turbulent transport within and just above the canopy in the roughness sublayer as well as the more complex snow scheme in CABLE relative to MOSES.« less

  8. Unified connected theory of few-body reaction mechanisms in N-body scattering theory

    NASA Technical Reports Server (NTRS)

    Polyzou, W. N.; Redish, E. F.

    1978-01-01

    A unified treatment of different reaction mechanisms in nonrelativistic N-body scattering is presented. The theory is based on connected kernel integral equations that are expected to become compact for reasonable constraints on the potentials. The operators T/sub +-//sup ab/(A) are approximate transition operators that describe the scattering proceeding through an arbitrary reaction mechanism A. These operators are uniquely determined by a connected kernel equation and satisfy an optical theorem consistent with the choice of reaction mechanism. Connected kernel equations relating T/sub +-//sup ab/(A) to the full T/sub +-//sup ab/ allow correction of the approximate solutions for any ignored process to any order. This theory gives a unified treatment of all few-body reaction mechanisms with the same dynamic simplicity of a model calculation, but can include complicated reaction mechanisms involving overlapping configurations where it is difficult to formulate models.

  9. Hilltop supernatural inflation and SUSY unified models

    NASA Astrophysics Data System (ADS)

    Kohri, Kazunori; Lim, C. S.; Lin, Chia-Min; Mimura, Yukihiro

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is ns = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) the role of inflaton.

  10. Unified Models of Turbulence and Nonlinear Wave Evolution in the Extended Solar Corona and Solar Wind

    NASA Technical Reports Server (NTRS)

    Cranmer, Steven R.; Wagner, William (Technical Monitor)

    2004-01-01

    The PI (Cranmer) and Co-I (A. van Ballegooijen) made substantial progress toward the goal of producing a unified model of the basic physical processes responsible for solar wind acceleration. The approach outlined in the original proposal comprised two complementary pieces: (1) to further investigate individual physical processes under realistic coronal and solar wind conditions, and (2) to extract the dominant physical effects from simulations and apply them to a 1D model of plasma heating and acceleration. The accomplishments in Year 2 are divided into these two categories: 1a. Focused Study of Kinetic Magnetohydrodynamic (MHD) Turbulence. lb. Focused Study of Non - WKB Alfven Wave Rejection. and 2. The Unified Model Code. We have continued the development of the computational model of a time-study open flux tube in the extended corona. The proton-electron Monte Carlo model is being tested, and collisionless wave-particle interactions are being included. In order to better understand how to easily incorporate various kinds of wave-particle processes into the code, the PI performed a detailed study of the so-called "Ito Calculus", i.e., the mathematical theory of how to update the positions of particles in a probabilistic manner when their motions are governed by diffusion in velocity space.

  11. Unified multiphase modeling for evolving, acoustically coupled systems consisting of acoustic, elastic, poroelastic media and septa

    NASA Astrophysics Data System (ADS)

    Lee, Joong Seok; Kang, Yeon June; Kim, Yoon Young

    2012-12-01

    This paper presents a new modeling technique that can represent acoustically coupled systems in a unified manner. The proposed unified multiphase (UMP) modeling technique uses Biot's equations that are originally derived for poroelastic media to represent not only poroelastic media but also non-poroelastic ones ranging from acoustic and elastic media to septa. To recover the original vibro-acoustic behaviors of non-poroelastic media, material parameters of a base poroelastic medium are adjusted depending on the target media. The real virtue of this UMP technique is that interface coupling conditions between any media can be automatically satisfied, so no medium-dependent interface condition needs to be imposed explicitly. Thereby, the proposed technique can effectively model any acoustically coupled system having locally varying medium phases and evolving interfaces. A typical situation can occur in an iterative design process. Because the proposed UMP modeling technique needs theoretical justifications for further development, this work is mainly focused on how the technique recovers the governing equations of non-poroelastic media and expresses their interface conditions. We also address how to describe various boundary conditions of the media in the technique. Some numerical studies are carried out to demonstrate the validity of the proposed modeling technique.

  12. An investigation of difficulties experienced by students developing unified modelling language (UML) class and sequence diagrams

    NASA Astrophysics Data System (ADS)

    Sien, Ven Yu

    2011-12-01

    Object-oriented analysis and design (OOAD) is not an easy subject to learn. There are many challenges confronting students when studying OOAD. Students have particular difficulty abstracting real-world problems within the context of OOAD. They are unable to effectively build object-oriented (OO) models from the problem domain because they essentially do not know "what" to model. This article investigates the difficulties and misconceptions undergraduate students have with analysing systems using unified modelling language analysis class and sequence diagrams. These models were chosen because they represent important static and dynamic aspects of the software system under development. The results of this study will help students produce effective OO models, and facilitate software engineering lecturers design learning materials and approaches for introductory OOAD courses.

  13. unmarked: An R package for fitting hierarchical models of wildlife occurrence and abundance

    USGS Publications Warehouse

    Fiske, Ian J.; Chandler, Richard B.

    2011-01-01

    Ecological research uses data collection techniques that are prone to substantial and unique types of measurement error to address scientific questions about species abundance and distribution. These data collection schemes include a number of survey methods in which unmarked individuals are counted, or determined to be present, at spatially- referenced sites. Examples include site occupancy sampling, repeated counts, distance sampling, removal sampling, and double observer sampling. To appropriately analyze these data, hierarchical models have been developed to separately model explanatory variables of both a latent abundance or occurrence process and a conditional detection process. Because these models have a straightforward interpretation paralleling mechanisms under which the data arose, they have recently gained immense popularity. The common hierarchical structure of these models is well-suited for a unified modeling interface. The R package unmarked provides such a unified modeling framework, including tools for data exploration, model fitting, model criticism, post-hoc analysis, and model comparison.

  14. Beyond the Unified Model

    NASA Astrophysics Data System (ADS)

    Frauendorf, S.

    2018-04-01

    The key elements of the Unified Model are reviewed. The microscopic derivation of the Bohr Hamiltonian by means of adiabatic time-dependent mean field theory is presented. By checking against experimental data the limitations of the Unified Model are delineated. The description of the strong coupling between the rotational and intrinsic degrees of freedom in framework of the rotating mean field is presented from a conceptual point of view. The classification of rotational bands as configurations of rotating quasiparticles is introduced. The occurrence of uniform rotation about an axis that differs from the principle axes of the nuclear density distribution is discussed. The physics behind this tilted-axis rotation, unknown in molecular physics, is explained on a basic level. The new symmetries of the rotating mean field that arise from the various orientations of the angular momentum vector with respect to the triaxial nuclear density distribution and their manifestation by the level sequence of rotational bands are discussed. Resulting phenomena, as transverse wobbling, rotational chirality, magnetic rotation and band termination are discussed. Using the concept of spontaneous symmetry breaking the microscopic underpinning of the rotational degrees is refined.

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Childs, Andrew M.; Center for Theoretical Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Leung, Debbie W.

    We present unified, systematic derivations of schemes in the two known measurement-based models of quantum computation. The first model (introduced by Raussendorf and Briegel, [Phys. Rev. Lett. 86, 5188 (2001)]) uses a fixed entangled state, adaptive measurements on single qubits, and feedforward of the measurement results. The second model (proposed by Nielsen, [Phys. Lett. A 308, 96 (2003)] and further simplified by Leung, [Int. J. Quant. Inf. 2, 33 (2004)]) uses adaptive two-qubit measurements that can be applied to arbitrary pairs of qubits, and feedforward of the measurement results. The underlying principle of our derivations is a variant of teleportationmore » introduced by Zhou, Leung, and Chuang, [Phys. Rev. A 62, 052316 (2000)]. Our derivations unify these two measurement-based models of quantum computation and provide significantly simpler schemes.« less

  16. Toward a unified approach to dose-response modeling in ecotoxicology.

    PubMed

    Ritz, Christian

    2010-01-01

    This study reviews dose-response models that are used in ecotoxicology. The focus lies on clarification of differences and similarities between models, and as a side effect, their different guises in ecotoxicology are unravelled. A look at frequently used dose-response models reveals major discrepancies, among other things in naming conventions. Therefore, there is a need for a unified view on dose-response modeling in order to improve the understanding of it and to facilitate communication and comparison of findings across studies, thus realizing its full potential. This study attempts to establish a general framework that encompasses most dose-response models that are of interest to ecotoxicologists in practice. The framework includes commonly used models such as the log-logistic and Weibull models, but also features entire suites of models as found in various guidance documents. An outline on how the proposed framework can be implemented in statistical software systems is also provided.

  17. Reduction of parameters in Finite Unified Theories and the MSSM

    NASA Astrophysics Data System (ADS)

    Heinemeyer, Sven; Mondragón, Myriam; Tracas, Nicholas; Zoupanos, George

    2018-02-01

    The method of reduction of couplings developed by W. Zimmermann, combined with supersymmetry, can lead to realistic quantum field theories, where the gauge and Yukawa sectors are related. It is the basis to find all-loop Finite Unified Theories, where the β-function vanishes to all-loops in perturbation theory. It can also be applied to the Minimal Supersymmetric Standard Model, leading to a drastic reduction in the number of parameters. Both Finite Unified Theories and the reduced MSSM lead to successful predictions for the masses of the third generation of quarks and the Higgs boson, and also predict a heavy supersymmetric spectrum, consistent with the non-observation of supersymmetry so far.

  18. VizieR Online Data Catalog: A dust model for bet Pic from 0.58 to 870um (Ballering+, 2016)

    NASA Astrophysics Data System (ADS)

    Ballering, N. P.; Su, K. Y. L.; Rieke, G. H.; Gaspar, A.

    2016-08-01

    β Pic was imaged with the HST/STIS CCD in coronagraphic (50CORON) mode under program GO-12551 (PI: Apai), and the results of these observations were published in Apai et al. (2015ApJ...800..136A). The instrument bandpass is set by the response of the CCD and centered at 0.58um. We searched the HST archive and found previously unpublished observations of β Pic with the WFC3 instrument in the IR channel (filter F110W at ~1.16um) from program GO-11150 (PI: Graham). The Spitzer/MIPS observations of β Pic were taken under the Spitzer Guaranteed Time Observing Program 90 (PI: M. Werner). The data at all three bands (24, 70, and 160um) are published here for the first time. Two sets of 24um observations were obtained. The first set was obtained on 2004 March 20, the second set of data was obtained on 2004 April 11. Two sets of 70um observations were obtained. The first set was obtained on 2004 April 12. The second set was obtained on 2005 April 4. Herschel/PACS 70um scan map observations of β Pic (PI G. Olofsson, observation IDs 1342186612 and 1342186613) were published by Vandenbussche et al. (2010A&A...518L.133V). We used the ALMA 870um continuum image previously published by Dent et al. (2014Sci...343.1490D). (1 data file).

  19. Selumetinib-based therapy in uveal melanoma patient-derived xenografts

    PubMed Central

    Decaudin, Didier; El Botty, Rania; Diallo, Béré; Massonnet, Gerald; Fleury, Justine; Naguez, Adnan; Raymondie, Chloé; Davies, Emma; Smith, Aaron; Wilson, Joanne; Howes, Colin; Smith, Paul D.; Cassoux, Nathalie; Piperno-Neumann, Sophie; Roman-Roman, Sergio; Némati, Fariba

    2018-01-01

    The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the activation of MAPK signaling in UM have raised hopes of more effective, targeted therapies, based on MEK inhibition, for example. We evaluated the potential of drug combinations to increase the efficacy of the MEK inhibitor selumetinib (AZD6244, ARRY-142886), in UM cell lines and Patient-Derived Xenografts. We first evaluated the combination of selumetinib and DTIC. We found that DTIC did not improve the in vitro or in vivo antitumor efficacy of selumetinib, consistent with the outcome of the SUMIT clinical trial assessing the efficacy of this combination in UM. We then tested additional selumetinib combinations with the chemotherapy agent docetaxel, the ERK inhibitor AZ6197, and the mTORC1/2 inhibitor, vistusertib (AZD2014). Combinations of selumetinib with ERK and mTORC1/2 inhibitors appeared to be the most effective in UM PDX models. PMID:29774094

  20. A Unified Model for BDS Wide Area and Local Area Augmentation Positioning Based on Raw Observations.

    PubMed

    Tu, Rui; Zhang, Rui; Lu, Cuixian; Zhang, Pengfei; Liu, Jinhai; Lu, Xiaochun

    2017-03-03

    In this study, a unified model for BeiDou Navigation Satellite System (BDS) wide area and local area augmentation positioning based on raw observations has been proposed. Applying this model, both the Real-Time Kinematic (RTK) and Precise Point Positioning (PPP) service can be realized by performing different corrections at the user end. This algorithm was assessed and validated with the BDS data collected at four regional stations from Day of Year (DOY) 080 to 083 of 2016. When the users are located within the local reference network, the fast and high precision RTK service can be achieved using the regional observation corrections, revealing a convergence time of about several seconds and a precision of about 2-3 cm. For the users out of the regional reference network, the global broadcast State-Space Represented (SSR) corrections can be utilized to realize the global PPP service which shows a convergence time of about 25 min for achieving an accuracy of 10 cm. With this unified model, it can not only integrate the Network RTK (NRTK) and PPP into a seamless positioning service, but also recover the ionosphere Vertical Total Electronic Content (VTEC) and Differential Code Bias (DCB) values that are useful for the ionosphere monitoring and modeling.

  1. A Unified Model for BDS Wide Area and Local Area Augmentation Positioning Based on Raw Observations

    PubMed Central

    Tu, Rui; Zhang, Rui; Lu, Cuixian; Zhang, Pengfei; Liu, Jinhai; Lu, Xiaochun

    2017-01-01

    In this study, a unified model for BeiDou Navigation Satellite System (BDS) wide area and local area augmentation positioning based on raw observations has been proposed. Applying this model, both the Real-Time Kinematic (RTK) and Precise Point Positioning (PPP) service can be realized by performing different corrections at the user end. This algorithm was assessed and validated with the BDS data collected at four regional stations from Day of Year (DOY) 080 to 083 of 2016. When the users are located within the local reference network, the fast and high precision RTK service can be achieved using the regional observation corrections, revealing a convergence time of about several seconds and a precision of about 2–3 cm. For the users out of the regional reference network, the global broadcast State-Space Represented (SSR) corrections can be utilized to realize the global PPP service which shows a convergence time of about 25 min for achieving an accuracy of 10 cm. With this unified model, it can not only integrate the Network RTK (NRTK) and PPP into a seamless positioning service, but also recover the ionosphere Vertical Total Electronic Content (VTEC) and Differential Code Bias (DCB) values that are useful for the ionosphere monitoring and modeling. PMID:28273814

  2. Kinetics of Cation and Oxyanion Adsorption and Desorption on Ferrihydrite: Roles of Ferrihydrite Binding Sites and a Unified Model.

    PubMed

    Tian, Lei; Shi, Zhenqing; Lu, Yang; Dohnalkova, Alice C; Lin, Zhang; Dang, Zhi

    2017-09-19

    Quantitative understanding the kinetics of toxic ion reactions with various heterogeneous ferrihydrite binding sites is crucial for accurately predicting the dynamic behavior of contaminants in environment. In this study, kinetics of As(V), Cr(VI), Cu(II), and Pb(II) adsorption and desorption on ferrihydrite was studied using a stirred-flow method, which showed that metal adsorption/desorption kinetics was highly dependent on the reaction conditions and varied significantly among four metals. High resolution scanning transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy showed that all four metals were distributed within the ferrihydrite aggregates homogeneously after adsorption reactions. Based on the equilibrium model CD-MUSIC, we developed a novel unified kinetics model applicable for both cation and oxyanion adsorption and desorption on ferrihydrite, which is able to account for the heterogeneity of ferrihydrite binding sites, different binding properties of cations and oxyanions, and variations of solution chemistry. The model described the kinetic results well. We quantitatively elucidated how the equilibrium properties of the cation and oxyanion binding to various ferrihydrite sites and the formation of various surface complexes controlled the adsorption and desorption kinetics at different reaction conditions and time scales. Our study provided a unified modeling method for the kinetics of ion adsorption/desorption on ferrihydrite.

  3. Petersen Multipliers for Several SEU (Single Event Upset) Environment Models.

    DTIC Science & Technology

    1986-09-30

    The Aerospace Corporation El Segundo, CA 90245 30 Scptcmbcr 1986 Prepared for SPACE DIVISION AIR FORCE SYSTEMS COMMAND 0Los Angeles Air Force Station...X (pC/om)2 /Um " (for S in Pm2 and for in picocoulombs per um). (In another system of units, the constant in the equation for F, above, takes the...distributions that may be expected under a wide variety of conditions. These models have since become standards for use in the specification of system

  4. Educational Technology Acceptance across Cultures: A Validation of the Unified Theory of Acceptance and Use of Technology in the Context of Turkish National Culture

    ERIC Educational Resources Information Center

    Gogus, Aytac; Nistor, Nicolae; Riley, Richard W.; Lerche, Thomas

    2012-01-01

    The Unified Theory of Acceptance and Use of Technology (UTAUT; Venkatesh et al., 2003, 2012) proposes a major model of educational technology acceptance (ETA) which has been yet validated only in few languages and cultures. Therefore, this study aims at extending the applicability of UTAUT to Turkish culture. Based on acceptance and cultural data…

  5. The Unified Behavior Framework for the Simulation of Autonomous Agents

    DTIC Science & Technology

    2015-03-01

    1980s, researchers have designed a variety of robot control architectures intending to imbue robots with some degree of autonomy. A recently developed ...Identification Friend or Foe viii THE UNIFIED BEHAVIOR FRAMEWORK FOR THE SIMULATION OF AUTONOMOUS AGENTS I. Introduction The development of autonomy has...room for research by utilizing methods like simulation and modeling that consume less time and fewer monetary resources. A recently developed reactive

  6. Evaluation of English Language Development Programs in the Santa Ana Unified School District. A Report on Data System Reliability and Statistical Modeling of Program Impacts.

    ERIC Educational Resources Information Center

    Mitchell, Douglas E.; Destino, Tom; Karam, Rita

    In response to concern about the effectiveness of programs for English-as-a-Second-Language students in California's schools, the Santa Ana Unified School District, in which over 80 percent of students are limited-English-proficient (LEP) conducted a study of both the operations and effectiveness of the district's language development program,…

  7. A unified model exploring parenting practices as mediators of marital conflict and children's adjustment.

    PubMed

    Coln, Kristen L; Jordan, Sara S; Mercer, Sterett H

    2013-06-01

    We examined positive and negative parenting practices and psychological control as mediators of the relations between constructive and destructive marital conflict and children's internalizing and externalizing problems in a unified model. Married mothers of 121 children between the ages of 6 and 12 completed questionnaires measuring marital conflict, parenting practices, and child adjustment. Analyses revealed significant direct paths from destructive marital conflict to negative parenting practices, psychological control, and both children's internalizing and externalizing behavior. In addition, psychological control was found to partially mediate relations between destructive marital conflict and children's internalizing and externalizing behavior.

  8. A quasi-likelihood approach to non-negative matrix factorization

    PubMed Central

    Devarajan, Karthik; Cheung, Vincent C.K.

    2017-01-01

    A unified approach to non-negative matrix factorization based on the theory of generalized linear models is proposed. This approach embeds a variety of statistical models, including the exponential family, within a single theoretical framework and provides a unified view of such factorizations from the perspective of quasi-likelihood. Using this framework, a family of algorithms for handling signal-dependent noise is developed and its convergence proven using the Expectation-Maximization algorithm. In addition, a measure to evaluate the goodness-of-fit of the resulting factorization is described. The proposed methods allow modeling of non-linear effects via appropriate link functions and are illustrated using an application in biomedical signal processing. PMID:27348511

  9. Hilltop supernatural inflation and SUSY unified models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kohri, Kazunori; Lim, C.S.; Lin, Chia-Min

    2014-01-01

    In this paper, we consider high scale (100TeV) supersymmetry (SUSY) breaking and realize the idea of hilltop supernatural inflation in concrete particle physics models based on flipped-SU(5)and Pati-Salam models in the framework of supersymmetric grand unified theories (SUSY GUTs). The inflaton can be a flat direction including right-handed sneutrino and the waterfall field is a GUT Higgs. The spectral index is n{sub s} = 0.96 which fits very well with recent data by PLANCK satellite. There is no both thermal and non-thermal gravitino problems. Non-thermal leptogenesis can be resulted from the decay of right-handed sneutrino which plays (part of) themore » role of inflaton.« less

  10. Customer-experienced rapid prototyping

    NASA Astrophysics Data System (ADS)

    Zhang, Lijuan; Zhang, Fu; Li, Anbo

    2008-12-01

    In order to describe accurately and comprehend quickly the perfect GIS requirements, this article will integrate the ideas of QFD (Quality Function Deployment) and UML (Unified Modeling Language), and analyze the deficiency of prototype development model, and will propose the idea of the Customer-Experienced Rapid Prototyping (CE-RP) and describe in detail the process and framework of the CE-RP, from the angle of the characteristics of Modern-GIS. The CE-RP is mainly composed of Customer Tool-Sets (CTS), Developer Tool-Sets (DTS) and Barrier-Free Semantic Interpreter (BF-SI) and performed by two roles of customer and developer. The main purpose of the CE-RP is to produce the unified and authorized requirements data models between customer and software developer.

  11. The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation*

    PubMed Central

    Davis, Ryan; Shi, Yongsheng

    2014-01-01

    The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3′ ends through a process called mRNA alternative polyadenylation (APA). Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation. PMID:24793760

  12. NCI HPC Scaling and Optimisation in Climate, Weather, Earth system science and the Geosciences

    NASA Astrophysics Data System (ADS)

    Evans, B. J. K.; Bermous, I.; Freeman, J.; Roberts, D. S.; Ward, M. L.; Yang, R.

    2016-12-01

    The Australian National Computational Infrastructure (NCI) has a national focus in the Earth system sciences including climate, weather, ocean, water management, environment and geophysics. NCI leads a Program across its partners from the Australian science agencies and research communities to identify priority computational models to scale-up. Typically, these cases place a large overall demand on the available computer time, need to scale to higher resolutions, use excessive scarce resources such as large memory or bandwidth that limits, or in some cases, need to meet requirements for transition to a separate operational forecasting system, with set time-windows. The model codes include the UK Met Office Unified Model atmospheric model (UM), GFDL's Modular Ocean Model (MOM), both the UK Met Office's GC3 and Australian ACCESS coupled-climate systems (including sea ice), 4D-Var data assimilation and satellite processing, the Regional Ocean Model (ROMS), and WaveWatch3 as well as geophysics codes including hazards, magentuellerics, seismic inversions, and geodesy. Many of these codes use significant compute resources both for research applications as well as within the operational systems. Some of these models are particularly complex, and their behaviour had not been critically analysed for effective use of the NCI supercomputer or how they could be improved. As part of the Program, we have established a common profiling methodology that uses a suite of open source tools for performing scaling analyses. The most challenging cases are profiling multi-model coupled systems where the component models have their own complex algorithms and performance issues. We have also found issues within the current suite of profiling tools, and no single tool fully exposes the nature of the code performance. As a result of this work, international collaborations are now in place to ensure that improvements are incorporated within the community models, and our effort can be targeted in a coordinated way. The coordinations have involved user stakeholders, the model developer community, and dependent software libraries. For example, we have spent significant time characterising I/O scalability, and improving the use of libraries such as NetCDF and HDF5.

  13. Microphysics in the Multi-Scale Modeling Systems with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Chern, J.; Lamg, S.; Matsui, T.; Shen, B.; Zeng, X.; Shi, R.

    2011-01-01

    In recent years, exponentially increasing computer power has extended Cloud Resolving Model (CRM) integrations from hours to months, the number of computational grid points from less than a thousand to close to ten million. Three-dimensional models are now more prevalent. Much attention is devoted to precipitating cloud systems where the crucial 1-km scales are resolved in horizontal domains as large as 10,000 km in two-dimensions, and 1,000 x 1,000 km2 in three-dimensions. Cloud resolving models now provide statistical information useful for developing more realistic physically based parameterizations for climate models and numerical weather prediction models. It is also expected that NWP and mesoscale model can be run in grid size similar to cloud resolving model through nesting technique. Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (l) a cloud-resolving model (Goddard Cumulus Ensemble model, GCE model), (2) a regional scale model (a NASA unified weather research and forecast, WRF), (3) a coupled CRM and global model (Goddard Multi-scale Modeling Framework, MMF), and (4) a land modeling system. The same microphysical processes, long and short wave radiative transfer and land processes and the explicit cloud-radiation, and cloud-surface interactive processes are applied in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator to use NASA high-resolution satellite data to identify the strengths and weaknesses of cloud and precipitation processes simulated by the model. In this talk, the microphysics developments of the multi-scale modeling system will be presented. In particular, the results from using multi-scale modeling system to study the heavy precipitation processes will be presented.

  14. Constitutive modeling for isotropic materials (HOST)

    NASA Technical Reports Server (NTRS)

    Chan, Kwai S.; Lindholm, Ulric S.; Bodner, S. R.; Hill, Jeff T.; Weber, R. M.; Meyer, T. G.

    1986-01-01

    The results of the third year of work on a program which is part of the NASA Hot Section Technology program (HOST) are presented. The goals of this program are: (1) the development of unified constitutive models for rate dependent isotropic materials; and (2) the demonstration of the use of unified models in structural analyses of hot section components of gas turbine engines. The unified models selected for development and evaluation are those of Bodner-Partom and of Walker. A test procedure was developed for assisting the generation of a data base for the Bodner-Partom model using a relatively small number of specimens. This test procedure involved performing a tensile test at a temperature of interest that involves a succession of strain-rate changes. The results for B1900+Hf indicate that material constants related to hardening and thermal recovery can be obtained on the basis of such a procedure. Strain aging, thermal recovery, and unexpected material variations, however, preluded an accurate determination of the strain-rate sensitivity parameter is this exercise. The effects of casting grain size on the constitutive behavior of B1900+Hf were studied and no particular grain size effect was observed. A systematic procedure was also developed for determining the material constants in the Bodner-Partom model. Both the new test procedure and the method for determining material constants were applied to the alternate material, Mar-M247 . Test data including tensile, creep, cyclic and nonproportional biaxial (tension/torsion) loading were collected. Good correlations were obtained between the Bodner-Partom model and experiments. A literature survey was conducted to assess the effects of thermal history on the constitutive behavior of metals. Thermal history effects are expected to be present at temperature regimes where strain aging and change of microstructure are important. Possible modifications to the Bodner-Partom model to account for these effects are outlined. The use of a unified constitutive model for hot section component analyses was demonstrated by applying the Walker model and the MARC finite-element code to a B1900+Hf airfoil problem.

  15. A unifying retinex model based on non-local differential operators

    NASA Astrophysics Data System (ADS)

    Zosso, Dominique; Tran, Giang; Osher, Stanley

    2013-02-01

    In this paper, we present a unifying framework for retinex that is able to reproduce many of the existing retinex implementations within a single model. The fundamental assumption, as shared with many retinex models, is that the observed image is a multiplication between the illumination and the true underlying reflectance of the object. Starting from Morel's 2010 PDE model for retinex, where illumination is supposed to vary smoothly and where the reflectance is thus recovered from a hard-thresholded Laplacian of the observed image in a Poisson equation, we define our retinex model in similar but more general two steps. First, look for a filtered gradient that is the solution of an optimization problem consisting of two terms: The first term is a sparsity prior of the reflectance, such as the TV or H1 norm, while the second term is a quadratic fidelity prior of the reflectance gradient with respect to the observed image gradients. In a second step, since this filtered gradient almost certainly is not a consistent image gradient, we then look for a reflectance whose actual gradient comes close. Beyond unifying existing models, we are able to derive entirely novel retinex formulations by using more interesting non-local versions for the sparsity and fidelity prior. Hence we define within a single framework new retinex instances particularly suited for texture-preserving shadow removal, cartoon-texture decomposition, color and hyperspectral image enhancement.

  16. Comments on “A Unified Representation of Deep Moist Convection in Numerical Modeling of the Atmosphere. Part I”

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Guang; Fan, Jiwen; Xu, Kuan-Man

    2015-06-01

    Arakawa and Wu (2013, hereafter referred to as AW13) recently developed a formal approach to a unified parameterization of atmospheric convection for high-resolution numerical models. The work is based on ideas formulated by Arakawa et al. (2011). It lays the foundation for a new parameterization pathway in the era of high-resolution numerical modeling of the atmosphere. The key parameter in this approach is convective cloud fraction. In conventional parameterization, it is assumed that <<1. This assumption is no longer valid when horizontal resolution of numerical models approaches a few to a few tens kilometers, since in such situations convective cloudmore » fraction can be comparable to unity. Therefore, they argue that the conventional approach to parameterizing convective transport must include a factor 1 - in order to unify the parameterization for the full range of model resolutions so that it is scale-aware and valid for large convective cloud fractions. While AW13’s approach provides important guidance for future convective parameterization development, in this note we intend to show that the conventional approach already has this scale awareness factor 1 - built in, although not recognized for the last forty years. Therefore, it should work well even in situations of large convective cloud fractions in high-resolution numerical models.« less

  17. Kinetics of Cation and Oxyanion Adsorption and Desorption on Ferrihydrite: Roles of Ferrihydrite Binding Sites and a Unified Model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tian, Lei; Shi, Zhenqing; Lu, Yang

    Understanding the kinetics of toxic ion reactions with ferrihydrite is crucial for predicting the dynamic behavior of contaminants in soil environments. In this study, the kinetics of As(V), Cr(VI), Cu, and Pb adsorption and desorption on ferrihydrite were investigated with a combination of laboratory macroscopic experiments, microscopic investigation and mechanistic modeling. The rates of As(V), Cr(VI), Cu, and Pb adsorption and desorption on ferrihydrite, as systematically studied using a stirred-flow method, was highly dependent on the reaction pH and metal concentrations and varied significantly among four metals. Spherical aberration-corrected scanning transmission electron microscopy (Cs-STEM) showed, at sub-nano scales, all fourmore » metals were distributed within the ferrihydrite particle aggregates homogeneously after adsorption reactions, with no evidence of surface diffusion-controlled processes. Based on experimental results, we developed a unifying kinetics model for both cation and oxyanion adsorption/desorption on ferrihydrite based on the mechanistic-based equilibrium model CD-MUSIC. Overall, the model described the kinetic results well, and we quantitatively demonstrated how the equilibrium properties of the cation and oxyanion binding to various ferrihydrite sites affected the adsorption and desorption rates. Our results provided a unifying quantitative modeling method for the kinetics of both cation and oxyanion adsorption/desorption on iron minerals.« less

  18. Three Tier Unified Process Model for Requirement Negotiations and Stakeholder Collaborations

    NASA Astrophysics Data System (ADS)

    Niazi, Muhammad Ashraf Khan; Abbas, Muhammad; Shahzad, Muhammad

    2012-11-01

    This research paper is focused towards carrying out a pragmatic qualitative analysis of various models and approaches of requirements negotiations (a sub process of requirements management plan which is an output of scope managementís collect requirements process) and studies stakeholder collaborations methodologies (i.e. from within communication management knowledge area). Experiential analysis encompass two tiers; first tier refers to the weighted scoring model while second tier focuses on development of SWOT matrices on the basis of findings of weighted scoring model for selecting an appropriate requirements negotiation model. Finally the results are simulated with the help of statistical pie charts. On the basis of simulated results of prevalent models and approaches of negotiations, a unified approach for requirements negotiations and stakeholder collaborations is proposed where the collaboration methodologies are embeded into selected requirements negotiation model as internal parameters of the proposed process alongside some external required parameters like MBTI, opportunity analysis etc.

  19. Unified semiclassical theory for the two-state system: an analytical solution for general nonadiabatic tunneling.

    PubMed

    Zhu, Chaoyuan; Lin, Sheng Hsien

    2006-07-28

    Unified semiclasical solution for general nonadiabatic tunneling between two adiabatic potential energy surfaces is established by employing unified semiclassical solution for pure nonadiabatic transition [C. Zhu, J. Chem. Phys. 105, 4159 (1996)] with the certain symmetry transformation. This symmetry comes from a detailed analysis of the reduced scattering matrix for Landau-Zener type of crossing as a special case of nonadiabatic transition and nonadiabatic tunneling. Traditional classification of crossing and noncrossing types of nonadiabatic transition can be quantitatively defined by the rotation angle of adiabatic-to-diabatic transformation, and this rotational angle enters the analytical solution for general nonadiabatic tunneling. The certain two-state exponential potential models are employed for numerical tests, and the calculations from the present general nonadiabatic tunneling formula are demonstrated in very good agreement with the results from exact quantum mechanical calculations. The present general nonadiabatic tunneling formula can be incorporated with various mixed quantum-classical methods for modeling electronically nonadiabatic processes in photochemistry.

  20. Workload capacity spaces: a unified methodology for response time measures of efficiency as workload is varied.

    PubMed

    Townsend, James T; Eidels, Ami

    2011-08-01

    Increasing the number of available sources of information may impair or facilitate performance, depending on the capacity of the processing system. Tests performed on response time distributions are proving to be useful tools in determining the workload capacity (as well as other properties) of cognitive systems. In this article, we develop a framework and relevant mathematical formulae that represent different capacity assays (Miller's race model bound, Grice's bound, and Townsend's capacity coefficient) in the same space. The new space allows a direct comparison between the distinct bounds and the capacity coefficient values and helps explicate the relationships among the different measures. An analogous common space is proposed for the AND paradigm, relating the capacity index to the Colonius-Vorberg bounds. We illustrate the effectiveness of the unified spaces by presenting data from two simulated models (standard parallel, coactive) and a prototypical visual detection experiment. A conversion table for the unified spaces is provided.

  1. Generalized Multilevel Structural Equation Modeling

    ERIC Educational Resources Information Center

    Rabe-Hesketh, Sophia; Skrondal, Anders; Pickles, Andrew

    2004-01-01

    A unifying framework for generalized multilevel structural equation modeling is introduced. The models in the framework, called generalized linear latent and mixed models (GLLAMM), combine features of generalized linear mixed models (GLMM) and structural equation models (SEM) and consist of a response model and a structural model for the latent…

  2. Activation of the Constitutive Androstane Receptor Inhibits Gluconeogenesis without Affecting Lipogenesis or Fatty Acid Synthesis in Human Hepatocytes

    PubMed Central

    Lynch, Caitlin; Pan, Yongmei; Li, Linhao; Heyward, Scott; Moeller, Timothy; Swaan, Peter W.; Wang, Hongbing

    2014-01-01

    Objective Accumulating evidence suggests that activation of mouse constitutive androstane receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic gluconeogenesis, lipogenesis, and fatty acid synthesis. However, the role of human (h) CAR in energy metabolism is largely unknown. The present study aims to investigate the effects of selective hCAR activators on hepatic energy metabolism in human primary hepatocytes (HPH). Methods Ligand-based structure-activity models were used for virtual screening of the Specs database (www.specs.net) followed by biological validation in cell-based luciferase assays. The effects of two novel hCAR activators (UM104 and UM145) on hepatic energy metabolism were evaluated in HPH. Results Real-time PCR and Western blotting analyses reveal that activation of hCAR by UM104 and UM145 significantly repressed the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, two pivotal gluconeogenic enzymes, while exerting negligible effects on the expression of genes associated with lipogenesis and fatty acid synthesis. Functional experiments show that UM104 and UM145 markedly inhibit hepatic synthesis of glucose but not triglycerides in HPH. In contrast, activation of mCAR by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a selective mCAR activator, repressed the expression of genes associated with gluconeogenesis, lipogenesis, and fatty acid synthesis in mouse primary hepatocytes, which were consistent with previous observations in mouse model in vivo. Conclusion Our findings uncover an important species difference between hCAR and mCAR in hepatic energy metabolism, where hCAR selectively inhibits gluconeogenesis without suppressing fatty acid synthesis. Implications Such species selectivity should be considered when exploring CAR as a potential therapeutic target for metabolic disorders. PMID:24878338

  3. Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.

    PubMed

    Némati, Fariba; de Montrion, Catherine; Lang, Guillaume; Kraus-Berthier, Laurence; Carita, Guillaume; Sastre-Garau, Xavier; Berniard, Aurélie; Vallerand, David; Geneste, Olivier; de Plater, Ludmilla; Pierré, Alain; Lockhart, Brian; Desjardins, Laurence; Piperno-Neumann, Sophie; Depil, Stéphane; Decaudin, Didier

    2014-01-01

    Uveal melanoma (UM) is associated with a high risk of metastases and lack of efficient therapies. Reduced capacity for apoptosis induction by chemotherapies is one obstacle to efficient treatments. Human UM is characterized by high expression of the anti-apoptotic protein Bcl-2. Consequently, regulators of apoptosis such as Bcl-2 family inhibitors may constitute an attractive approach to UM therapeutics. In this aim, we have investigated the efficacy of the Bcl-2/Bcl-XL inhibitor S44563 on 4 UM Patient-Derived Xenografts (PDXs) and derived-cell lines. Four well characterized UM PDXs were used for in vivo experiments. S44563 was administered alone or combined with fotemustine either concomitantly or after the alkylating agent. Bcl-2, Bcl-XL, and Mcl-1 expressions after S44563 administration were evaluated by immunohistochemistry (IHC). S44563 administered alone by at 50 and 100 mg/kg i.p. induced a significant tumour growth inhibition in only one xenograft model with a clear dose effect. However, when S44563 was concomitantly administered with fotemustine, we observed a synergistic activity in 3 out of the 4 tested models. In addition, S44563 administered after fotemustine induced a tumour growth delay in 2 out of 3 tested xenografts. Finally, IHC analyses showed that Bcl-2, Bcl-XL, and Mcl-1 expression were not modified after S44563 administration. The novel anti-apoptotic experimental compound S44563, despite a relative low efficacy when administered alone, increased the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine. These data support further exploration of potential therapeutic effect of Bcl-2/Bcl-xl inhibition in human UM.

  4. Toward a unified account of comprehension and production in language development.

    PubMed

    McCauley, Stewart M; Christiansen, Morten H

    2013-08-01

    Although Pickering & Garrod (P&G) argue convincingly for a unified system for language comprehension and production, they fail to explain how such a system might develop. Using a recent computational model of language acquisition as an example, we sketch a developmental perspective on the integration of comprehension and production. We conclude that only through development can we fully understand the intertwined nature of comprehension and production in adult processing.

  5. Mission Assurance in a Distributed Environment

    DTIC Science & Technology

    2009-06-01

    Notation ( BPMN ) – Graphical representation of business processes in a workflow • Unified Modeling Language (UML) – Use standard UML diagrams to model the system – Component, sequence, activity diagrams

  6. Singular F(R) cosmology unifying early- and late-time acceleration with matter and radiation domination era

    NASA Astrophysics Data System (ADS)

    Odintsov, S. D.; Oikonomou, V. K.

    2016-06-01

    We present some cosmological models which unify the late- and early-time acceleration eras with the radiation and the matter domination era, and we realize the cosmological models by using the theoretical framework of F(R) gravity. Particularly, the first model unifies the late- and early-time acceleration with the matter domination era, and the second model unifies all the evolution eras of our Universe. The two models are described in the same way at early and late times, and only the intermediate stages of the evolution have some differences. Each cosmological model contains two Type IV singularities which are chosen to occur one at the end of the inflationary era and one at the end of the matter domination era. The cosmological models at early times are approximately identical to the R 2 inflation model, so these describe a slow-roll inflationary era which ends when the slow-roll parameters become of order one. The inflationary era is followed by the radiation era and after that the matter domination era follows, which lasts until the second Type IV singularity, and then the late-time acceleration era follows. The models have two appealing features: firstly they produce a nearly scale invariant power spectrum of primordial curvature perturbations and a scalar-to-tensor ratio which are compatible with the most recent observational data and secondly, it seems that the deceleration-acceleration transition is crucially affected by the presence of the second Type IV singularity which occurs at the end of the matter domination era. As we demonstrate, the Hubble horizon at early times shrinks, as expected for an initially accelerating Universe, then during the matter domination era, it expands and finally after the Type IV singularity, the Hubble horizon starts to shrink again, during the late-time acceleration era. Intriguingly enough, the deceleration-acceleration transition, occurs after the second Type IV singularity. In addition, we investigate which F(R) gravity can successfully realize each of the four cosmological epochs.

  7. On numerical integration and computer implementation of viscoplastic models

    NASA Technical Reports Server (NTRS)

    Chang, T. Y.; Chang, J. P.; Thompson, R. L.

    1985-01-01

    Due to the stringent design requirement for aerospace or nuclear structural components, considerable research interests have been generated on the development of constitutive models for representing the inelastic behavior of metals at elevated temperatures. In particular, a class of unified theories (or viscoplastic constitutive models) have been proposed to simulate material responses such as cyclic plasticity, rate sensitivity, creep deformations, strain hardening or softening, etc. This approach differs from the conventional creep and plasticity theory in that both the creep and plastic deformations are treated as unified time-dependent quantities. Although most of viscoplastic models give better material behavior representation, the associated constitutive differential equations have stiff regimes which present numerical difficulties in time-dependent analysis. In this connection, appropriate solution algorithm must be developed for viscoplastic analysis via finite element method.

  8. The application of the unified modeling language in object-oriented analysis of healthcare information systems.

    PubMed

    Aggarwal, Vinod

    2002-10-01

    This paper concerns itself with the beneficial effects of the Unified Modeling Language (UML), a nonproprietary object modeling standard, in specifying, visualizing, constructing, documenting, and communicating the model of a healthcare information system from the user's perspective. The author outlines the process of object-oriented analysis (OOA) using the UML and illustrates this with healthcare examples to demonstrate the practicality of application of the UML by healthcare personnel to real-world information system problems. The UML will accelerate advanced uses of object-orientation such as reuse technology, resulting in significantly higher software productivity. The UML is also applicable in the context of a component paradigm that promises to enhance the capabilities of healthcare information systems and simplify their management and maintenance.

  9. Unifying models of dialect spread and extinction using surface tension dynamics

    PubMed Central

    2018-01-01

    We provide a unified mathematical explanation of two classical forms of spatial linguistic spread. The wave model describes the radiation of linguistic change outwards from a central focus. Changes can also jump between population centres in a process known as hierarchical diffusion. It has recently been proposed that the spatial evolution of dialects can be understood using surface tension at linguistic boundaries. Here we show that the inclusion of long-range interactions in the surface tension model generates both wave-like spread, and hierarchical diffusion, and that it is surface tension that is the dominant effect in deciding the stable distribution of dialect patterns. We generalize the model to allow population mixing which can induce shrinkage of linguistic domains, or destroy dialect regions from within. PMID:29410847

  10. Building unified geospatial data for land-change modeling—A case study in the area of Richmond, Virginia

    USGS Publications Warehouse

    Donato, David I.; Shapiro, Jason L.

    2016-12-13

    An effort to build a unified collection of geospatial data for use in land-change modeling (LCM) led to new insights into the requirements and challenges of building an LCM data infrastructure. A case study of data compilation and unification for the Richmond, Va., Metropolitan Statistical Area (MSA) delineated the problems of combining and unifying heterogeneous data from many independent localities such as counties and cities. The study also produced conclusions and recommendations for use by the national LCM community, emphasizing the critical need for simple, practical data standards and conventions for use by localities. This report contributes an uncopyrighted core glossary and a much needed operational definition of data unification.

  11. The resolution sensitivity of the Asian summer monsoon and its inter-model comparison between MRI-AGCM and MetUM

    NASA Astrophysics Data System (ADS)

    Ogata, Tomomichi; Johnson, Stephanie J.; Schiemann, Reinhard; Demory, Marie-Estelle; Mizuta, Ryo; Yoshida, Kohei; Osamu Arakawa

    2017-11-01

    In this study, we compare the resolution sensitivity of the Asian Summer Monsoon (ASM) in two Atmospheric General Circulation Models (AGCMs): the MRI-AGCM and the MetUM. We analyze the MetUM at three different resolutions, N96 (approximately 200-km mesh on the equator), N216 (90-km mesh) and N512 (40-km mesh), and the MRI-AGCM at TL95 (approximately 180-km mesh on the equator), TL319 (60-km mesh), and TL959 (20-km mesh). The MRI-AGCM and the MetUM both show decreasing precipitation over the western Pacific with increasing resolution, but their precipitation responses differ over the Indian Ocean. In MRI-AGCM, a large precipitation increase appears off the equator (5-20°N). In MetUM, this off-equatorial precipitation increase is less significant and precipitation decreases over the equator. Moisture budget analysis demonstrates that a changing in moisture flux convergence at higher resolution is related to the precipitation response. Orographic effects, intra-seasonal variability and the representation of the meridional thermal gradient are explored as possible causes of the resolution sensitivity. Both high-resolution AGCMs (TL959 and N512) can represent steep topography, which anchors the rainfall pattern over south Asia and the Maritime Continent. In MRI-AGCM, representation of low pressure systems in TL959 also contributes to the rainfall pattern. Furthermore, the seasonal evolution of the meridional thermal gradient appears to be more accurate at higher resolution, particularly in the MRI-AGCM. These findings emphasize that the impact of resolution is only robust across the two AGCMs for some features of the ASM, and highlights the importance of multi-model studies of GCM resolution sensitivity.

  12. The evaluation and development of the Met Office Unified Model using surface and space borne radar.

    NASA Astrophysics Data System (ADS)

    Petch, J.

    2012-12-01

    The Met Office Unified Model is used for the prediction of weather and climate on time scales of hours through to centuries. Therefore, the parametrizations in that model need to work on weather and climate timescale, and with grid-lengths from hundres of meters through to several hundred kilometres. Focusing on the development of the cloud and radiation schemes I will discuss how we are using ground-based remote-sensing observations from Chilbolton (England) and a combination of Cloudsat and Calipso data to evaluate and improve the performance of the model. I will show how the prediction of the clouds has improved since the AR5 version of the model and how we have developed an improved cloud generator to rebresent the sub-grid variability of clouds for radiative transfer.

  13. Relevance, textual unity, and politeness in writing about science

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kreml, N.M.P.

    1992-01-01

    The question of whether there are social implications of linguistic choices in unifying a text is investigated empirically by this study which accounts for the interpretation of implicatures in conversation and written texts. It considers Relevance Theory (Sperber and Wilson 1988, Blakemore 1987, Blass 1990) to be the explanation of the unity of the text, as opposed to semantic theories of cohesion (Halliday and Hasan 1976) or pragmatic theories of coherence (van Dijk 1977). This study presents a model of three types of textual unifiers: overt (referring specifically to the text), embedded (referring to intra- and extra-textual information), and inferencemore » (not referring to the text at all). It hypothesizes that different genres are characterized by the predominance of different types of textual unifiers, and that readers will prefer those texts that rely on inferential unifiers which emphasize the reader's ability to participate in creating the meaning of the text. Eighteen texts of 275 words each are selected from three genres: scientific magazines, introductory science textbooks, and essays on science. The texts are found to vary significantly by genre in the type of textual unifier used. An Overtness Index expresses the ratio of the marked forms: science textbooks have more Overt unifiers (such as connective phrases) and thus a high Overtness Index; essays rely more on Inference unifiers (not represented by words) and thus have a low Overtness Index. The texts are submitted to 188 readers, and a significantly high number of all types of readers prefer the texts with the lower Overtness Indices-the essays. Thus a low Overtness Index is one feature of texts preferred by readers, supporting the hypotheses that genres of texts vary in the type of unifier used and that readers prefer texts that allow them to participate in constructing the meaning of the text.« less

  14. The effects of surface chemistry of mesoporous silica materials and solution pH on kinetics of molsidomine adsorption

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dolinina, E.S.; Parfenyuk, E.V., E-mail: terrakott37@mail.ru

    2014-01-15

    Adsorption kinetics of molsidomine on mesoporous silica material (UMS), the phenyl- (PhMS) and mercaptopropyl-functionalized (MMS) derivatives from solution with different pH and 298 K was studied. The adsorption kinetics was found to follow the pseudo-second-order kinetic model for all studied silica materials and pH. Effects of surface functional groups and pH on adsorption efficiency and kinetic adsorption parameters were investigated. At all studied pH, the highest molsidomine amount is adsorbed on PhMS due to π–π interactions and hydrogen bonding between surface groups of PhMS and molsidomine molecules. An increase of pH results in a decrease of the amounts of adsorbedmore » molsidomine onto the silica materials. Furthermore, the highest adsorption rate kinetically evaluated using a pseudo-second-order model, is observed onto UMS and it strongly depends on pH. The mechanism of the adsorption process was determined from the intraparticle diffusion and Boyd kinetic film–diffusion models. The results showed that the molsidomine adsorption on the silica materials is controlled by film diffusion. Effect of pH on the diffusion parameters is discussed. - Graphical abstract: The kinetic study showed that the k{sub 2} value, the rate constant of pseudo-second order kinetic model, is the highest for molsidomine adsorption on UMS and strongly depends on pH because it is determined by availability and accessibility of the reaction sites of the adsorbents molsidomine binding. Display Omitted - Highlights: • The adsorption capacities of UMS, PhMS and MMS were dependent on the pH. • At all studied pH, the highest molsidomine amount is adsorbed on PhMS. • The highest adsorption rate, k{sub 2}, is observed onto UMS and strongly depends on pH. • Film diffusion was the likely rate-limiting step in the adsorption process.« less

  15. DICOM static and dynamic representation through unified modeling language

    NASA Astrophysics Data System (ADS)

    Martinez-Martinez, Alfonso; Jimenez-Alaniz, Juan R.; Gonzalez-Marquez, A.; Chavez-Avelar, N.

    2004-04-01

    The DICOM standard, as all standards, specifies in generic way the management in network and storage media environments of digital medical images and their related information. However, understanding the specifications for particular implementation is not a trivial work. Thus, this work is about understanding and modelling parts of the DICOM standard using Object Oriented methodologies, as part of software development processes. This has offered different static and dynamic views, according with the standard specifications, and the resultant models have been represented through the Unified Modelling Language (UML). The modelled parts are related to network conformance claim: Network Communication Support for Message Exchange, Message Exchange, Information Object Definitions, Service Class Specifications, Data Structures and Encoding, and Data Dictionary. The resultant models have given a better understanding about DICOM parts and have opened the possibility of create a software library to develop DICOM conformable PACS applications.

  16. Final Technical Report for "Reducing tropical precipitation biases in CESM"

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larson, Vincent

    In state-of-the-art climate models, each cloud type is treated using its own separate cloud parameterization and its own separate microphysics parameterization. This use of separate schemes for separate cloud regimes is undesirable because it is theoretically unfounded, it hampers interpretation of results, and it leads to the temptation to overtune parameters. In this grant, we have created a climate model that contains a unified cloud parameterization (“CLUBB”) and a unified microphysics parameterization (“MG2”). In this model, all cloud types --- including marine stratocumulus, shallow cumulus, and deep cumulus --- are represented with a single equation set. This model improves themore » representation of convection in the Tropics. The model has been compared with ARM observations. The chief benefit of the project is to provide a climate model that is based on a more theoretically rigorous formulation.« less

  17. A unified model for reverberation and submerged object scattering in a stratified ocean waveguide.

    PubMed

    Makris, N C; Ratilal, P

    2001-03-01

    A unified model for reverberation and submerged target scattering in a stratified medium is developed from wave theory. The advantage of the unified approach is that it enables quantitative predictions to be made of the target-echo-to-reverberation ratio in an ocean waveguide. Analytic expressions are derived for both deterministic and stochastic scattering from the seafloor and subseafloor. Asymptotic techniques are used to derive expressions for the scattering of broadband waveforms from distant objects or surfaces. Expressions are then obtained for the scattered field after beamforming with a horizontal line array. The model is applied to problems of active detection in shallow water. Sample calculations for narrow-band signals indicate that the detection of submerged target echoes above diffuse seafloor reverberation is highly dependent upon water column and sediment stratification as well as array aperture, source, receiver, and target locations, in addition to the scattering properties of the target and seafloor. The model is also applied to determine the conditions necessary for echo returns from discrete geomorphologic features of the seafloor and subseafloor to stand prominently above diffuse seafloor reverberation. This has great relevance to the geologic clutter problem encountered by active sonar systems operating in shallow water, as well as to the remote sensing of underwater geomorphology.

  18. Constitutive modeling for isotropic materials (HOST)

    NASA Technical Reports Server (NTRS)

    Lindholm, Ulric S.; Chan, Kwai S.; Bodner, S. R.; Weber, R. M.; Walker, K. P.; Cassenti, B. N.

    1984-01-01

    The results of the first year of work on a program to validate unified constitutive models for isotropic materials utilized in high temperature regions of gas turbine engines and to demonstrate their usefulness in computing stress-strain-time-temperature histories in complex three-dimensional structural components. The unified theories combine all inelastic strain-rate components in a single term avoiding, for example, treating plasticity and creep as separate response phenomena. An extensive review of existing unified theories is given and numerical methods for integrating these stiff time-temperature-dependent constitutive equations are discussed. Two particular models, those developed by Bodner and Partom and by Walker, were selected for more detailed development and evaluation against experimental tensile, creep and cyclic strain tests on specimens of a cast nickel base alloy, B19000+Hf. Initial results comparing computed and test results for tensile and cyclic straining for temperature from ambient to 982 C and strain rates from 10(exp-7) 10(exp-3) s(exp-1) are given. Some preliminary date correlations are presented also for highly non-proportional biaxial loading which demonstrate an increase in biaxial cyclic hardening rate over uniaxial or proportional loading conditions. Initial work has begun on the implementation of both constitutive models in the MARC finite element computer code.

  19. Constitutive modeling for isotropic materials

    NASA Technical Reports Server (NTRS)

    Chan, K. S.; Lindholm, U. S.; Bodner, S. R.

    1988-01-01

    The third and fourth years of a 4-year research program, part of the NASA HOST Program, are described. The program goals were: (1) to develop and validate unified constitutive models for isotropic materials, and (2) to demonstrate their usefulness for structural analysis of hot section components of gas turbine engines. The unified models selected for development and evaluation were those of Bodner-Partom and of Walker. The unified approach for elastic-viscoplastic constitutive equations is a viable method for representing and predicting material response characteristics in the range where strain rate and temperature dependent inelastic deformations are experienced. This conclusion is reached by extensive comparison of model calculations against the experimental results of a test program of two high temperature Ni-base alloys, B1900+Hf and Mar-M247, over a wide temperature range for a variety of deformation and thermal histories including uniaxial, multiaxial, and thermomechanical loading paths. The applicability of the Bodner-Partom and the Walker models for structural applications has been demonstrated by implementing these models into the MARC finite element code and by performing a number of analyses including thermomechanical histories on components of hot sections of gas turbine engines and benchmark notch tensile specimens. The results of the 4-year program have been published in four annual reports. The results of the base program are summarized in this report. The tasks covered include: (1) development of material test procedures, (2) thermal history effects, and (3) verification of the constitutive model for an alternative material.

  20. Unified Performance and Power Modeling of Scientific Workloads

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Song, Shuaiwen; Barker, Kevin J.; Kerbyson, Darren J.

    2013-11-17

    It is expected that scientific applications executing on future large-scale HPC must be optimized not only in terms of performance, but also in terms of power consumption. As power and energy become increasingly constrained resources, researchers and developers must have access to tools that will allow for accurate prediction of both performance and power consumption. Reasoning about performance and power consumption in concert will be critical for achieving maximum utilization of limited resources on future HPC systems. To this end, we present a unified performance and power model for the Nek-Bone mini-application developed as part of the DOE's CESAR Exascalemore » Co-Design Center. Our models consider the impact of computation, point-to-point communication, and collective communication« less

  1. Model for Transport and Luminescence in Porous Silicon

    NASA Astrophysics Data System (ADS)

    John, George C.; Singh, Vijay A.

    1996-03-01

    A unified model for explaining the transport and luminescence properties of porous silicon has remained elusive(G.C.John and V.A.Singh, Phys. Rep. (in press)). The conductivity of porous silicon has been reported to increase exponentially with temperature(J.J.Mares et al.), Appl. Phys. Lett. 63, 180 (1993). We report additional observations of such instances. This Berthelot type behavior is ascribed to tunneling of carriers across a vibrating barrier. We hypothesize that the non-radiative recombination in porous silicon is governed by a similar mechanism. Based on this assumption, we show that the temperature and pressure dependence of luminescence in porous silicon can be convincingly explained. We present a unified phenomenological model which can account for a range of observations in porous silicon.

  2. UNITED STATES METEOROLOGICAL DATA - DAILY AND HOURLY FILES TO SUPPORT PREDICTIVE EXPOSURE MODELING

    EPA Science Inventory

    ORD numerical models for pesticide exposure include a model of spray drift (AgDisp), a cropland pesticide persistence model (PRZM), a surface water exposure model (EXAMS), and a model of fish bioaccumulation (BASS). A unified climatological database for these models has been asse...

  3. Predicting crystal growth via a unified kinetic three-dimensional partition model

    NASA Astrophysics Data System (ADS)

    Anderson, Michael W.; Gebbie-Rayet, James T.; Hill, Adam R.; Farida, Nani; Attfield, Martin P.; Cubillas, Pablo; Blatov, Vladislav A.; Proserpio, Davide M.; Akporiaye, Duncan; Arstad, Bjørnar; Gale, Julian D.

    2017-04-01

    Understanding and predicting crystal growth is fundamental to the control of functionality in modern materials. Despite investigations for more than one hundred years, it is only recently that the molecular intricacies of these processes have been revealed by scanning probe microscopy. To organize and understand this large amount of new information, new rules for crystal growth need to be developed and tested. However, because of the complexity and variety of different crystal systems, attempts to understand crystal growth in detail have so far relied on developing models that are usually applicable to only one system. Such models cannot be used to achieve the wide scope of understanding that is required to create a unified model across crystal types and crystal structures. Here we describe a general approach to understanding and, in theory, predicting the growth of a wide range of crystal types, including the incorporation of defect structures, by simultaneous molecular-scale simulation of crystal habit and surface topology using a unified kinetic three-dimensional partition model. This entails dividing the structure into ‘natural tiles’ or Voronoi polyhedra that are metastable and, consequently, temporally persistent. As such, these units are then suitable for re-construction of the crystal via a Monte Carlo algorithm. We demonstrate our approach by predicting the crystal growth of a diverse set of crystal types, including zeolites, metal-organic frameworks, calcite, urea and L-cystine.

  4. Efficient construction of unified continuous and discontinuous Galerkin formulations for the 3D Euler equations

    NASA Astrophysics Data System (ADS)

    Abdi, Daniel S.; Giraldo, Francis X.

    2016-09-01

    A unified approach for the numerical solution of the 3D hyperbolic Euler equations using high order methods, namely continuous Galerkin (CG) and discontinuous Galerkin (DG) methods, is presented. First, we examine how classical CG that uses a global storage scheme can be constructed within the DG framework using constraint imposition techniques commonly used in the finite element literature. Then, we implement and test a simplified version in the Non-hydrostatic Unified Model of the Atmosphere (NUMA) for the case of explicit time integration and a diagonal mass matrix. Constructing CG within the DG framework allows CG to benefit from the desirable properties of DG such as, easier hp-refinement, better stability etc. Moreover, this representation allows for regional mixing of CG and DG depending on the flow regime in an area. The different flavors of CG and DG in the unified implementation are then tested for accuracy and performance using a suite of benchmark problems representative of cloud-resolving scale, meso-scale and global-scale atmospheric dynamics. The value of our unified approach is that we are able to show how to carry both CG and DG methods within the same code and also offer a simple recipe for modifying an existing CG code to DG and vice versa.

  5. Nearshore Wave and Circulation Modelling

    DTIC Science & Technology

    1998-02-01

    1995), "The unified Kadomtsev - Petviashvili equation for interfacial waves," J. Fluid Mech., 288, 383-408. Chen, Y. and Liu, P. L.-F. (1996), "On...modified Kadomtsev - Petviashvili equation for interfacial wave propagation near the critical depth level," Wave Motion (to appear). Cox, D. T. and Kobayashi...94-13. Chen, Y. and Liu, P.L.-F. (1995), "Numerical Study of the Unified Kadomtsev - Petviashvili Equation ," CACR-95-04. Chen, Y. and Liu, P.L.-F

  6. Unified web-based network management based on distributed object orientated software agents

    NASA Astrophysics Data System (ADS)

    Djalalian, Amir; Mukhtar, Rami; Zukerman, Moshe

    2002-09-01

    This paper presents an architecture that provides a unified web interface to managed network devices that support CORBA, OSI or Internet-based network management protocols. A client gains access to managed devices through a web browser, which is used to issue management operations and receive event notifications. The proposed architecture is compatible with both the OSI Management reference Model and CORBA. The steps required for designing the building blocks of such architecture are identified.

  7. Impacts of increasing the aerosol complexity in the Met Office global numerical weather prediction model

    NASA Astrophysics Data System (ADS)

    Mulcahy, J. P.; Walters, D. N.; Bellouin, N.; Milton, S. F.

    2014-05-01

    The inclusion of the direct and indirect radiative effects of aerosols in high-resolution global numerical weather prediction (NWP) models is being increasingly recognised as important for the improved accuracy of short-range weather forecasts. In this study the impacts of increasing the aerosol complexity in the global NWP configuration of the Met Office Unified Model (MetUM) are investigated. A hierarchy of aerosol representations are evaluated including three-dimensional monthly mean speciated aerosol climatologies, fully prognostic aerosols modelled using the CLASSIC aerosol scheme and finally, initialised aerosols using assimilated aerosol fields from the GEMS project. The prognostic aerosol schemes are better able to predict the temporal and spatial variation of atmospheric aerosol optical depth, which is particularly important in cases of large sporadic aerosol events such as large dust storms or forest fires. Including the direct effect of aerosols improves model biases in outgoing long-wave radiation over West Africa due to a better representation of dust. However, uncertainties in dust optical properties propagate to its direct effect and the subsequent model response. Inclusion of the indirect aerosol effects improves surface radiation biases at the North Slope of Alaska ARM site due to lower cloud amounts in high-latitude clean-air regions. This leads to improved temperature and height forecasts in this region. Impacts on the global mean model precipitation and large-scale circulation fields were found to be generally small in the short-range forecasts. However, the indirect aerosol effect leads to a strengthening of the low-level monsoon flow over the Arabian Sea and Bay of Bengal and an increase in precipitation over Southeast Asia. Regional impacts on the African Easterly Jet (AEJ) are also presented with the large dust loading in the aerosol climatology enhancing of the heat low over West Africa and weakening the AEJ. This study highlights the importance of including a more realistic treatment of aerosol-cloud interactions in global NWP models and the potential for improved global environmental prediction systems through the incorporation of more complex aerosol schemes.

  8. Impacts of increasing the aerosol complexity in the Met Office global NWP model

    NASA Astrophysics Data System (ADS)

    Mulcahy, J. P.; Walters, D. N.; Bellouin, N.; Milton, S. F.

    2013-11-01

    Inclusion of the direct and indirect radiative effects of aerosols in high resolution global numerical weather prediction (NWP) models is being increasingly recognised as important for the improved accuracy of short-range weather forecasts. In this study the impacts of increasing the aerosol complexity in the global NWP configuration of the Met Office Unified Model (MetUM) are investigated. A hierarchy of aerosol representations are evaluated including three dimensional monthly mean speciated aerosol climatologies, fully prognostic aerosols modelled using the CLASSIC aerosol scheme and finally, initialised aerosols using assimilated aerosol fields from the GEMS project. The prognostic aerosol schemes are better able to predict the temporal and spatial variation of atmospheric aerosol optical depth, which is particularly important in cases of large sporadic aerosol events such as large dust storms or forest fires. Including the direct effect of aerosols improves model biases in outgoing longwave radiation over West Africa due to a better representation of dust. However, uncertainties in dust optical properties propogate to its direct effect and the subsequent model response. Inclusion of the indirect aerosol effects improves surface radiation biases at the North Slope of Alaska ARM site due to lower cloud amounts in high latitude clean air regions. This leads to improved temperature and height forecasts in this region. Impacts on the global mean model precipitation and large-scale circulation fields were found to be generally small in the short range forecasts. However, the indirect aerosol effect leads to a strengthening of the low level monsoon flow over the Arabian Sea and Bay of Bengal and an increase in precipitation over Southeast Asia. Regional impacts on the African Easterly Jet (AEJ) are also presented with the large dust loading in the aerosol climatology enhancing of the heat low over West Africa and weakening the AEJ. This study highlights the importance of including a~more realistic treatment of aerosol-cloud interactions in global NWP models and the potential for improved global environmental prediction systems through the incorporation of more complex aerosol schemes.

  9. Introduction to Theoretical Modelling

    NASA Astrophysics Data System (ADS)

    Davis, Matthew J.; Gardiner, Simon A.; Hanna, Thomas M.; Nygaard, Nicolai; Proukakis, Nick P.; Szymańska, Marzena H.

    2013-02-01

    We briefly overview commonly encountered theoretical notions arising in the modelling of quantum gases, intended to provide a unified background to the `language' and diverse theoretical models presented elsewhere in this book, and aimed particularly at researchers from outside the quantum gases community.

  10. On The Modeling of Educational Systems: II

    ERIC Educational Resources Information Center

    Grauer, Robert T.

    1975-01-01

    A unified approach to model building is developed from the separate techniques of regression, simulation, and factorial design. The methodology is applied in the context of a suburban school district. (Author/LS)

  11. Interannual rainfall variability over China in the MetUM GA6 and GC2 configurations

    NASA Astrophysics Data System (ADS)

    Stephan, Claudia Christine; Klingaman, Nicholas P.; Vidale, Pier Luigi; Turner, Andrew G.; Demory, Marie-Estelle; Guo, Liang

    2018-05-01

    Six climate simulations of the Met Office Unified Model Global Atmosphere 6.0 and Global Coupled 2.0 configurations are evaluated against observations and reanalysis data for their ability to simulate the mean state and year-to-year variability of precipitation over China. To analyse the sensitivity to air-sea coupling and horizontal resolution, atmosphere-only and coupled integrations at atmospheric horizontal resolutions of N96, N216 and N512 (corresponding to ˜ 200, 90 and 40 km in the zonal direction at the equator, respectively) are analysed. The mean and interannual variance of seasonal precipitation are too high in all simulations over China but improve with finer resolution and coupling. Empirical orthogonal teleconnection (EOT) analysis is applied to simulated and observed precipitation to identify spatial patterns of temporally coherent interannual variability in seasonal precipitation. To connect these patterns to large-scale atmospheric and coupled air-sea processes, atmospheric and oceanic fields are regressed onto the corresponding seasonal mean time series. All simulations reproduce the observed leading pattern of interannual rainfall variability in winter, spring and autumn; the leading pattern in summer is present in all but one simulation. However, only in two simulations are the four leading patterns associated with the observed physical mechanisms. Coupled simulations capture more observed patterns of variability and associate more of them with the correct physical mechanism, compared to atmosphere-only simulations at the same resolution. However, finer resolution does not improve the fidelity of these patterns or their associated mechanisms. This shows that evaluating climate models by only geographical distribution of mean precipitation and its interannual variance is insufficient. The EOT analysis adds knowledge about coherent variability and associated mechanisms.

  12. An integrative model of auditory phantom perception: tinnitus as a unified percept of interacting separable subnetworks.

    PubMed

    De Ridder, Dirk; Vanneste, Sven; Weisz, Nathan; Londero, Alain; Schlee, Winnie; Elgoyhen, Ana Belen; Langguth, Berthold

    2014-07-01

    Tinnitus is a considered to be an auditory phantom phenomenon, a persistent conscious percept of a salient memory trace, externally attributed, in the absence of a sound source. It is perceived as a phenomenological unified coherent percept, binding multiple separable clinical characteristics, such as its loudness, the sidedness, the type (pure tone, noise), the associated distress and so on. A theoretical pathophysiological framework capable of explaining all these aspects in one model is highly needed. The model must incorporate both the deafferentation based neurophysiological models and the dysfunctional noise canceling model, and propose a 'tinnitus core' subnetwork. The tinnitus core can be defined as the minimal set of brain areas that needs to be jointly activated (=subnetwork) for tinnitus to be consciously perceived, devoid of its affective components. The brain areas involved in the other separable characteristics of tinnitus can be retrieved by studies on spontaneous resting state magnetic and electrical activity in people with tinnitus, evaluated for the specific aspect investigated and controlled for other factors. By combining these functional imaging studies with neuromodulation techniques some of the correlations are turned into causal relationships. Thereof, a heuristic pathophysiological framework is constructed, integrating the tinnitus perceptual core with the other tinnitus related aspects. This phenomenological unified percept of tinnitus can be considered an emergent property of multiple, parallel, dynamically changing and partially overlapping subnetworks, each with a specific spontaneous oscillatory pattern and functional connectivity signature. Communication between these different subnetworks is proposed to occur at hubs, brain areas that are involved in multiple subnetworks simultaneously. These hubs can take part in each separable subnetwork at different frequencies. Communication between the subnetworks is proposed to occur at discrete oscillatory frequencies. As such, the brain uses multiple nonspecific networks in parallel, each with their own oscillatory signature, that adapt to the context to construct a unified percept possibly by synchronized activation integrated at hubs at discrete oscillatory frequencies. Copyright © 2013 Elsevier Ltd. All rights reserved.

  13. Research and development activities in unified control-structure modeling and design

    NASA Technical Reports Server (NTRS)

    Nayak, A. P.

    1985-01-01

    Results of work sponsored by JPL and other organizations to develop a unified control/structures modeling and design capability for large space structures is presented. Recent analytical results are presented to demonstrate the significant interdependence between structural and control properties. A new design methodology is suggested in which the structure, material properties, dynamic model and control design are all optimized simultaneously. The development of a methodology for global design optimization is recommended as a long term goal. It is suggested that this methodology should be incorporated into computer aided engineering programs, which eventually will be supplemented by an expert system to aid design optimization. Recommendations are also presented for near term research activities at JPL. The key recommendation is to continue the development of integrated dynamic modeling/control design techniques, with special attention given to the development of structural models specially tailored to support design.

  14. Modeling a Nursing Guideline with Standard Terminology and Unified Modeling Language for a Nursing Decision Support System: A Case Study.

    PubMed

    Choi, Jeeyae; Jansen, Kay; Coenen, Amy

    In recent years, Decision Support Systems (DSSs) have been developed and used to achieve "meaningful use". One approach to developing DSSs is to translate clinical guidelines into a computer-interpretable format. However, there is no specific guideline modeling approach to translate nursing guidelines to computer-interpretable guidelines. This results in limited use of DSSs in nursing. Unified modeling language (UML) is a software writing language known to accurately represent the end-users' perspective, due to its expressive characteristics. Furthermore, standard terminology enabled DSSs have been shown to smoothly integrate into existing health information systems. In order to facilitate development of nursing DSSs, the UML was used to represent a guideline for medication management for older adults encode with the International Classification for Nursing Practice (ICNP®). The UML was found to be a useful and sufficient tool to model a nursing guideline for a DSS.

  15. A time for multi-scale modeling of anti-fibrotic therapies. Comment on "Towards a unified approach in the modeling of fibrosis: A review with research perspectives" by Martine Ben Amar and Carlo Bianca

    NASA Astrophysics Data System (ADS)

    Wu, Min

    2016-07-01

    The development of anti-fibrotic therapies in diversities of diseases becomes more and more urgent recently, such as in pulmonary, renal and liver fibrosis [1,2], as well as in malignant tumor growths [3]. As reviewed by Ben Amar and Bianca [4], various theoretical, experimental and in-silico models have been developed to understand the fibrosis process, where the implication on therapeutic strategies has also been frequently demonstrated (e.g., [5-7]). In [4], these models are analyzed and sorted according to their approaches, and in the end of [4], a unified multi-scale approach was proposed to understand fibrosis. While one of the major purposes of extensive modeling of fibrosis is to shed light on therapeutic strategies, the theoretical, experimental and in-silico studies of anti-fibrosis therapies should be conducted more intensively.

  16. Exploring natural supersymmetry at the LHC

    NASA Astrophysics Data System (ADS)

    Nasir, Fariha

    This dissertation demonstrates how a variety of supersymmetric grand unified theories can resolve the little hierarchy problem in the minimal supersymmetric standard model and also explain the observed deviation in the anomalous magnetic moment of the muon. The origin of the little hierarchy problem lies in the sensitive manner in which the Z boson mass depends on parameters that can be much larger than its mass. Large values of these parameters imply that a large fine tuning is required to obtain the correct Z boson mass. With large fine tuning supersymmetry appears unnatural which is why models that attempt to resolve this problem are referred to as natural SUSY models. We show that a possible way to exhibit natural supersymmetry is to assume non-universal gauginos in a class of supersymmetric grand unified models. We further show that considering non-universal gauginos in a class of supersymmetric models can help explain the apparent anomaly in the magnetic moment of the muon.

  17. Modeling a Nursing Guideline with Standard Terminology and Unified Modeling Language for a Nursing Decision Support System: A Case Study

    PubMed Central

    Choi, Jeeyae; Jansen, Kay; Coenen, Amy

    2015-01-01

    In recent years, Decision Support Systems (DSSs) have been developed and used to achieve “meaningful use”. One approach to developing DSSs is to translate clinical guidelines into a computer-interpretable format. However, there is no specific guideline modeling approach to translate nursing guidelines to computer-interpretable guidelines. This results in limited use of DSSs in nursing. Unified modeling language (UML) is a software writing language known to accurately represent the end-users’ perspective, due to its expressive characteristics. Furthermore, standard terminology enabled DSSs have been shown to smoothly integrate into existing health information systems. In order to facilitate development of nursing DSSs, the UML was used to represent a guideline for medication management for older adults encode with the International Classification for Nursing Practice (ICNP®). The UML was found to be a useful and sufficient tool to model a nursing guideline for a DSS. PMID:26958174

  18. Standard representation and unified stability analysis for dynamic artificial neural network models.

    PubMed

    Kim, Kwang-Ki K; Patrón, Ernesto Ríos; Braatz, Richard D

    2018-02-01

    An overview is provided of dynamic artificial neural network models (DANNs) for nonlinear dynamical system identification and control problems, and convex stability conditions are proposed that are less conservative than past results. The three most popular classes of dynamic artificial neural network models are described, with their mathematical representations and architectures followed by transformations based on their block diagrams that are convenient for stability and performance analyses. Classes of nonlinear dynamical systems that are universally approximated by such models are characterized, which include rigorous upper bounds on the approximation errors. A unified framework and linear matrix inequality-based stability conditions are described for different classes of dynamic artificial neural network models that take additional information into account such as local slope restrictions and whether the nonlinearities within the DANNs are odd. A theoretical example shows reduced conservatism obtained by the conditions. Copyright © 2017. Published by Elsevier Ltd.

  19. ADAM-M Data and Information

    Atmospheric Science Data Center

    2017-05-11

    ... Information Creating a Unified Airborne Database for Assessment and Validation of Global Models of Atmospheric ...  (3)  To generate a standardized in-situ observational database with best possible matching temporal and spatial scales to model ...

  20. An Investigation of Unified Memory Access Performance in CUDA

    PubMed Central

    Landaverde, Raphael; Zhang, Tiansheng; Coskun, Ayse K.; Herbordt, Martin

    2015-01-01

    Managing memory between the CPU and GPU is a major challenge in GPU computing. A programming model, Unified Memory Access (UMA), has been recently introduced by Nvidia to simplify the complexities of memory management while claiming good overall performance. In this paper, we investigate this programming model and evaluate its performance and programming model simplifications based on our experimental results. We find that beyond on-demand data transfers to the CPU, the GPU is also able to request subsets of data it requires on demand. This feature allows UMA to outperform full data transfer methods for certain parallel applications and small data sizes. We also find, however, that for the majority of applications and memory access patterns, the performance overheads associated with UMA are significant, while the simplifications to the programming model restrict flexibility for adding future optimizations. PMID:26594668

  1. Information Object Definition–based Unified Modeling Language Representation of DICOM Structured Reporting

    PubMed Central

    Tirado-Ramos, Alfredo; Hu, Jingkun; Lee, K.P.

    2002-01-01

    Supplement 23 to DICOM (Digital Imaging and Communications for Medicine), Structured Reporting, is a specification that supports a semantically rich representation of image and waveform content, enabling experts to share image and related patient information. DICOM SR supports the representation of textual and coded data linked to images and waveforms. Nevertheless, the medical information technology community needs models that work as bridges between the DICOM relational model and open object-oriented technologies. The authors assert that representations of the DICOM Structured Reporting standard, using object-oriented modeling languages such as the Unified Modeling Language, can provide a high-level reference view of the semantically rich framework of DICOM and its complex structures. They have produced an object-oriented model to represent the DICOM SR standard and have derived XML-exchangeable representations of this model using World Wide Web Consortium specifications. They expect the model to benefit developers and system architects who are interested in developing applications that are compliant with the DICOM SR specification. PMID:11751804

  2. AN APPROACH TO A UNIFIED PROCESS-BASED REGIONAL EMISSION FLUX MODELING PLATFORM

    EPA Science Inventory

    The trend towards episodic modeling of environmentally-dependent emissions is increasing, with models available or under development for dust, ammonia, biogenic volatile organic compounds, soil nitrous oxide, pesticides, sea salt, and chloride, mercury, and wildfire emissions. T...

  3. The Unified Plant Growth Model (UPGM): software framework overview and model application

    USDA-ARS?s Scientific Manuscript database

    Since the Environmental Policy Integrated Climate (EPIC) model was developed in 1989, the EPIC plant growth component has been incorporated into other erosion and crop management models (e.g., WEPS, WEPP, SWAT, ALMANAC, and APEX) and modified to meet model developer research objectives. This has re...

  4. WICS: A New Model for School Psychology

    ERIC Educational Resources Information Center

    Sternberg, Robert J.

    2010-01-01

    This article presents a unified model for cognitive processing, WICS, which is an acronym for wisdom, intelligence, and creativity, synthesized. The model can be applied to identification/admissions, diagnosis, instruction, and assessment. I discuss why there is a need for such a model. Then I describe traditional models, after which I describe…

  5. Impacts of increasing the aerosol complexity in the Met Office global NWP model

    NASA Astrophysics Data System (ADS)

    Mulcahy, Jane; Walters, David; Bellouin, Nicolas; Milton, Sean

    2014-05-01

    Inclusion of the direct and indirect radiative effects of aerosols in high resolution global numerical weather prediction (NWP) models is being increasingly recognised as important for the improved accuracy of short-range weather forecasts. In this study the impacts of increasing the aerosol complexity in the global NWP configuration of the Met Office Unified Model (MetUM) are investigated. A hierarchy of aerosol representations are evaluated including three dimensional monthly mean speciated aerosol climatologies, fully prognostic aerosols modelled using the CLASSIC aerosol scheme and finally, initialised aerosols using assimilated aerosol fields from the GEMS project. The prognostic aerosol schemes are better able to predict the temporal and spatial variation of atmospheric aerosol optical depth, which is particularly important in cases of large sporadic aerosol events such as large dust storms or forest fires. Including the direct effect of aerosols improves model biases in outgoing longwave radiation over West Africa due to a better representation of dust. Inclusion of the indirect aerosol effects has significant impacts on the SW radiation particularly at high latitudes due to lower cloud amounts in high latitude clean air regions. This leads to improved surface radiation biases at the North Slope of Alaska ARM site. Verification of temperature and height forecasts is also improved in this region. Impacts on the global mean model precipitation and large-scale circulation fields were found to be generally small in the short range forecasts. However, the indirect aerosol effect leads to a strengthening of the low level monsoon flow over the Arabian Sea and Bay of Bengal and an increase in precipitation over Southeast Asia. This study highlights the importance of including a more realistic treatment of aerosol-cloud interactions in global NWP models and the potential for improved global environmental prediction systems through the incorporation of more complex aerosol schemes. This work is distributed under the Creative Commons Attribution 3.0 Unported License together with an author copyright. This license does not conflict with the regulations of the Crown Copyright.

  6. Statistical power for nonequivalent pretest-posttest designs. The impact of change-score versus ANCOVA models.

    PubMed

    Oakes, J M; Feldman, H A

    2001-02-01

    Nonequivalent controlled pretest-posttest designs are central to evaluation science, yet no practical and unified approach for estimating power in the two most widely used analytic approaches to these designs exists. This article fills the gap by presenting and comparing useful, unified power formulas for ANCOVA and change-score analyses, indicating the implications of each on sample-size requirements. The authors close with practical recommendations for evaluators. Mathematical details and a simple spreadsheet approach are included in appendices.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Santos, A.F., E-mail: alesandroferreira@fisica.ufmt.br; Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Road Victoria, BC; Khanna, Faqir C., E-mail: khannaf@uvic.ca

    Dynamics between particles is governed by Lorentz and CPT symmetry. There is a violation of Parity (P) and CP symmetry at low levels. The unified theory, that includes particle physics and quantum gravity, may be expected to be covariant with Lorentz and CPT symmetry. At high enough energies, will the unified theory display violation of any symmetry? The Standard Model Extension (SME), with Lorentz and CPT violating terms, has been suggested to include particle dynamics. The minimal SME in the pure photon sector is considered in order to calculate the Casimir effect at finite temperature.

  8. IMPETUS - Interactive MultiPhysics Environment for Unified Simulations.

    PubMed

    Ha, Vi Q; Lykotrafitis, George

    2016-12-08

    We introduce IMPETUS - Interactive MultiPhysics Environment for Unified Simulations, an object oriented, easy-to-use, high performance, C++ program for three-dimensional simulations of complex physical systems that can benefit a large variety of research areas, especially in cell mechanics. The program implements cross-communication between locally interacting particles and continuum models residing in the same physical space while a network facilitates long-range particle interactions. Message Passing Interface is used for inter-processor communication for all simulations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. A unified theory of development: a dialectic integration of nature and nurture.

    PubMed

    Sameroff, Arnold

    2010-01-01

    The understanding of nature and nurture within developmental science has evolved with alternating ascendance of one or the other as primary explanations for individual differences in life course trajectories of success or failure. A dialectical perspective emphasizing the interconnectedness of individual and context is suggested to interpret the evolution of developmental science in similar terms to those necessary to explain the development of individual children. A unified theory of development is proposed to integrate personal change, context, regulation, and representational models of development.

  10. Towards a Global Unified Model of Europa's Tenuous Atmosphere

    NASA Astrophysics Data System (ADS)

    Plainaki, Christina; Cassidy, Tim A.; Shematovich, Valery I.; Milillo, Anna; Wurz, Peter; Vorburger, Audrey; Roth, Lorenz; Galli, André; Rubin, Martin; Blöcker, Aljona; Brandt, Pontus C.; Crary, Frank; Dandouras, Iannis; Jia, Xianzhe; Grassi, Davide; Hartogh, Paul; Lucchetti, Alice; McGrath, Melissa; Mangano, Valeria; Mura, Alessandro; Orsini, Stefano; Paranicas, Chris; Radioti, Aikaterini; Retherford, Kurt D.; Saur, Joachim; Teolis, Ben

    2018-02-01

    Despite the numerous modeling efforts of the past, our knowledge on the radiation-induced physical and chemical processes in Europa's tenuous atmosphere and on the exchange of material between the moon's surface and Jupiter's magnetosphere remains limited. In lack of an adequate number of in situ observations, the existence of a wide variety of models based on different scenarios and considerations has resulted in a fragmentary understanding of the interactions of the magnetospheric ion population with both the moon's icy surface and neutral gas envelope. Models show large discrepancy in the source and loss rates of the different constituents as well as in the determination of the spatial distribution of the atmosphere and its variation with time. The existence of several models based on very different approaches highlights the need of a detailed comparison among them with the final goal of developing a unified model of Europa's tenuous atmosphere. The availability to the science community of such a model could be of particular interest in view of the planning of the future mission observations (e.g., ESA's JUpiter ICy moons Explorer (JUICE) mission, and NASA's Europa Clipper mission). We review the existing models of Europa's tenuous atmosphere and discuss each of their derived characteristics of the neutral environment. We also discuss discrepancies among different models and the assumptions of the plasma environment in the vicinity of Europa. A summary of the existing observations of both the neutral and the plasma environments at Europa is also presented. The characteristics of a global unified model of the tenuous atmosphere are, then, discussed. Finally, we identify needed future experimental work in laboratories and propose some suitable observation strategies for upcoming missions.

  11. Information system end-user satisfaction and continuance intention: A unified modeling approach.

    PubMed

    Hadji, Brahim; Degoulet, Patrice

    2016-06-01

    Permanent evaluation of end-user satisfaction and continuance intention is a critical issue at each phase of a clinical information system (CIS) project, but most validation studies are concerned with the pre- or early post-adoption phases. The purpose of this study was twofold: to validate at the Pompidou University Hospital (HEGP) an information technology late post-adoption model built from four validated models and to propose a unified metamodel of evaluation that could be adapted to each context or deployment phase of a CIS project. Five dimensions, i.e., CIS quality (CISQ), perceived usefulness (PU), confirmation of expectations (CE), user satisfaction (SAT), and continuance intention (CI) were selected to constitute the CI evaluation model. The validity of the model was tested using the combined answers to four surveys performed between 2011 and 2015, i.e., more than ten years after the opening of HEGP in July 2000. Structural equation modeling was used to test the eight model-associated hypotheses. The multi-professional study group of 571 responders consisted of 158 doctors, 282 nurses, and 131 secretaries. The evaluation model accounted for 84% of variance of satisfaction and 53% of CI variance for the period 2011-2015 and for 92% and 69% for the period 2014-2015. In very late post adoption, CISQ appears to be the major determinant of satisfaction and CI. Combining the results obtained at various phases of CIS deployment, a Unified Model of Information System Continuance (UMISC) is proposed. In a meaningful CIS use situation at HEGP, this study confirms the importance of CISQ in explaining satisfaction and CI. The proposed UMISC model that can be adapted to each phase of CIS deployment could facilitate the necessary efforts of permanent CIS acceptance and continuance evaluation. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Unified underpinning of human mobility in the real world and cyberspace

    NASA Astrophysics Data System (ADS)

    Zhao, Yi-Ming; Zeng, An; Yan, Xiao-Yong; Wang, Wen-Xu; Lai, Ying-Cheng

    2016-05-01

    Human movements in the real world and in cyberspace affect not only dynamical processes such as epidemic spreading and information diffusion but also social and economical activities such as urban planning and personalized recommendation in online shopping. Despite recent efforts in characterizing and modeling human behaviors in both the real and cyber worlds, the fundamental dynamics underlying human mobility have not been well understood. We develop a minimal, memory-based random walk model in limited space for reproducing, with a single parameter, the key statistical behaviors characterizing human movements in both cases. The model is validated using relatively big data from mobile phone and online commerce, suggesting memory-based random walk dynamics as the unified underpinning for human mobility, regardless of whether it occurs in the real world or in cyberspace.

  13. Model-Unified Planning and Execution for Distributed Autonomous System Control

    NASA Technical Reports Server (NTRS)

    Aschwanden, Pascal; Baskaran, Vijay; Bernardini, Sara; Fry, Chuck; Moreno, Maria; Muscettola, Nicola; Plaunt, Chris; Rijsman, David; Tompkins, Paul

    2006-01-01

    The Intelligent Distributed Execution Architecture (IDEA) is a real-time architecture that exploits artificial intelligence planning as the core reasoning engine for interacting autonomous agents. Rather than enforcing separate deliberation and execution layers, IDEA unifies them under a single planning technology. Deliberative and reactive planners reason about and act according to a single representation of the past, present and future domain state. The domain state behaves the rules dictated by a declarative model of the subsystem to be controlled, internal processes of the IDEA controller, and interactions with other agents. We present IDEA concepts - modeling, the IDEA core architecture, the unification of deliberation and reaction under planning - and illustrate its use in a simple example. Finally, we present several real-world applications of IDEA, and compare IDEA to other high-level control approaches.

  14. A unified framework for heat and mass transport at the atomic scale

    NASA Astrophysics Data System (ADS)

    Ponga, Mauricio; Sun, Dingyi

    2018-04-01

    We present a unified framework to simulate heat and mass transport in systems of particles. The proposed framework is based on kinematic mean field theory and uses a phenomenological master equation to compute effective transport rates between particles without the need to evaluate operators. We exploit this advantage and apply the model to simulate transport phenomena at the nanoscale. We demonstrate that, when calibrated to experimentally-measured transport coefficients, the model can accurately predict transient and steady state temperature and concentration profiles even in scenarios where the length of the device is comparable to the mean free path of the carriers. Through several example applications, we demonstrate the validity of our model for all classes of materials, including ones that, until now, would have been outside the domain of computational feasibility.

  15. A unified theoretical framework for mapping models for the multi-state Hamiltonian.

    PubMed

    Liu, Jian

    2016-11-28

    We propose a new unified theoretical framework to construct equivalent representations of the multi-state Hamiltonian operator and present several approaches for the mapping onto the Cartesian phase space. After mapping an F-dimensional Hamiltonian onto an F+1 dimensional space, creation and annihilation operators are defined such that the F+1 dimensional space is complete for any combined excitation. Commutation and anti-commutation relations are then naturally derived, which show that the underlying degrees of freedom are neither bosons nor fermions. This sets the scene for developing equivalent expressions of the Hamiltonian operator in quantum mechanics and their classical/semiclassical counterparts. Six mapping models are presented as examples. The framework also offers a novel way to derive such as the well-known Meyer-Miller model.

  16. Astronomical Calendar and Restoration Design of Clepsydra in the Silla era

    NASA Astrophysics Data System (ADS)

    Lee, Yong Sam; Jeong, Jang Hae; Sang, Hyuk Kim; Lee, Yong Bok

    2008-09-01

    We study on the astronomical calendars that was used in the Silla era. The calendars are deduced from the records in Samguksagi. They were influenced from calendaric system of Tang Dynasty, which are Lin duk calendar(?), Ta yen calendar(?) and Sun myung calendar(?). We analyse them in detail according to the time and duration of use. Water clock system of Unified Silla was used four water vessels for supplying water. We found the model from documents on ancient water clock that are appeared in the old Korean, Chinese and Japanese historical records. We have assumed the model of Unified Silla clepsydra is similar type with Chinese records during Tang dynasty and with Japanese reconstructed water clock in Temple Asoka. After fluid dynamic experiment, we decide the suitable diameter of supplying pipe and volume of the vessels used in the clepsydra. We introduce the experimental instruments and methods for accomplishing the clock. We designed and reconstructed the water clock of Unified Silla and float rods for measuring time, that is based on the Silla's calendaric system.

  17. Toward a unifying framework for evolutionary processes.

    PubMed

    Paixão, Tiago; Badkobeh, Golnaz; Barton, Nick; Çörüş, Doğan; Dang, Duc-Cuong; Friedrich, Tobias; Lehre, Per Kristian; Sudholt, Dirk; Sutton, Andrew M; Trubenová, Barbora

    2015-10-21

    The theory of population genetics and evolutionary computation have been evolving separately for nearly 30 years. Many results have been independently obtained in both fields and many others are unique to its respective field. We aim to bridge this gap by developing a unifying framework for evolutionary processes that allows both evolutionary algorithms and population genetics models to be cast in the same formal framework. The framework we present here decomposes the evolutionary process into its several components in order to facilitate the identification of similarities between different models. In particular, we propose a classification of evolutionary operators based on the defining properties of the different components. We cast several commonly used operators from both fields into this common framework. Using this, we map different evolutionary and genetic algorithms to different evolutionary regimes and identify candidates with the most potential for the translation of results between the fields. This provides a unified description of evolutionary processes and represents a stepping stone towards new tools and results to both fields. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Resource management and scheduling policy based on grid for AIoT

    NASA Astrophysics Data System (ADS)

    Zou, Yiqin; Quan, Li

    2017-07-01

    This paper has a research on resource management and scheduling policy based on grid technology for Agricultural Internet of Things (AIoT). Facing the situation of a variety of complex and heterogeneous agricultural resources in AIoT, it is difficult to represent them in a unified way. But from an abstract perspective, there are some common models which can express their characteristics and features. Based on this, we proposed a high-level model called Agricultural Resource Hierarchy Model (ARHM), which can be used for modeling various resources. It introduces the agricultural resource modeling method based on this model. Compared with traditional application-oriented three-layer model, ARHM can hide the differences of different applications and make all applications have a unified interface layer and be implemented without distinction. Furthermore, it proposes a Web Service Resource Framework (WSRF)-based resource management method and the encapsulation structure for it. Finally, it focuses on the discussion of multi-agent-based AG resource scheduler, which is a collaborative service provider pattern in multiple agricultural production domains.

  19. Experimental analysis of chaotic neural network models for combinatorial optimization under a unifying framework.

    PubMed

    Kwok, T; Smith, K A

    2000-09-01

    The aim of this paper is to study both the theoretical and experimental properties of chaotic neural network (CNN) models for solving combinatorial optimization problems. Previously we have proposed a unifying framework which encompasses the three main model types, namely, Chen and Aihara's chaotic simulated annealing (CSA) with decaying self-coupling, Wang and Smith's CSA with decaying timestep, and the Hopfield network with chaotic noise. Each of these models can be represented as a special case under the framework for certain conditions. This paper combines the framework with experimental results to provide new insights into the effect of the chaotic neurodynamics of each model. By solving the N-queen problem of various sizes with computer simulations, the CNN models are compared in different parameter spaces, with optimization performance measured in terms of feasibility, efficiency, robustness and scalability. Furthermore, characteristic chaotic neurodynamics crucial to effective optimization are identified, together with a guide to choosing the corresponding model parameters.

  20. Unified Computational Methods for Regression Analysis of Zero-Inflated and Bound-Inflated Data

    PubMed Central

    Yang, Yan; Simpson, Douglas

    2010-01-01

    Bounded data with excess observations at the boundary are common in many areas of application. Various individual cases of inflated mixture models have been studied in the literature for bound-inflated data, yet the computational methods have been developed separately for each type of model. In this article we use a common framework for computing these models, and expand the range of models for both discrete and semi-continuous data with point inflation at the lower boundary. The quasi-Newton and EM algorithms are adapted and compared for estimation of model parameters. The numerical Hessian and generalized Louis method are investigated as means for computing standard errors after optimization. Correlated data are included in this framework via generalized estimating equations. The estimation of parameters and effectiveness of standard errors are demonstrated through simulation and in the analysis of data from an ultrasound bioeffect study. The unified approach enables reliable computation for a wide class of inflated mixture models and comparison of competing models. PMID:20228950

  1. A Multi-scale Modeling System with Unified Physics to Study Precipitation Processes

    NASA Astrophysics Data System (ADS)

    Tao, W. K.

    2017-12-01

    In recent years, exponentially increasing computer power has extended Cloud Resolving Model (CRM) integrations from hours to months, the number of computational grid points from less than a thousand to close to ten million. Three-dimensional models are now more prevalent. Much attention is devoted to precipitating cloud systems where the crucial 1-km scales are resolved in horizontal domains as large as 10,000 km in two-dimensions, and 1,000 x 1,000 km2 in three-dimensions. Cloud resolving models now provide statistical information useful for developing more realistic physically based parameterizations for climate models and numerical weather prediction models. It is also expected that NWP and mesoscale model can be run in grid size similar to cloud resolving model through nesting technique. Recently, a multi-scale modeling system with unified physics was developed at NASA Goddard. It consists of (1) a cloud-resolving model (Goddard Cumulus Ensemble model, GCE model), (2) a regional scale model (a NASA unified weather research and forecast, WRF), and (3) a coupled CRM and global model (Goddard Multi-scale Modeling Framework, MMF). The same microphysical processes, long and short wave radiative transfer and land processes and the explicit cloud-radiation, and cloud-land surface interactive processes are applied in this multi-scale modeling system. This modeling system has been coupled with a multi-satellite simulator to use NASA high-resolution satellite data to identify the strengths and weaknesses of cloud and precipitation processes simulated by the model. In this talk, a review of developments and applications of the multi-scale modeling system will be presented. In particular, the results from using multi-scale modeling system to study the precipitation, processes and their sensitivity on model resolution and microphysics schemes will be presented. Also how to use of the multi-satellite simulator to improve precipitation processes will be discussed.

  2. A Unified Analysis of Structured Sonar-terrain Data using Bayesian Functional Mixed Models.

    PubMed

    Zhu, Hongxiao; Caspers, Philip; Morris, Jeffrey S; Wu, Xiaowei; Müller, Rolf

    2018-01-01

    Sonar emits pulses of sound and uses the reflected echoes to gain information about target objects. It offers a low cost, complementary sensing modality for small robotic platforms. While existing analytical approaches often assume independence across echoes, real sonar data can have more complicated structures due to device setup or experimental design. In this paper, we consider sonar echo data collected from multiple terrain substrates with a dual-channel sonar head. Our goals are to identify the differential sonar responses to terrains and study the effectiveness of this dual-channel design in discriminating targets. We describe a unified analytical framework that achieves these goals rigorously, simultaneously, and automatically. The analysis was done by treating the echo envelope signals as functional responses and the terrain/channel information as covariates in a functional regression setting. We adopt functional mixed models that facilitate the estimation of terrain and channel effects while capturing the complex hierarchical structure in data. This unified analytical framework incorporates both Gaussian models and robust models. We fit the models using a full Bayesian approach, which enables us to perform multiple inferential tasks under the same modeling framework, including selecting models, estimating the effects of interest, identifying significant local regions, discriminating terrain types, and describing the discriminatory power of local regions. Our analysis of the sonar-terrain data identifies time regions that reflect differential sonar responses to terrains. The discriminant analysis suggests that a multi- or dual-channel design achieves target identification performance comparable with or better than a single-channel design.

  3. A Unified Analysis of Structured Sonar-terrain Data using Bayesian Functional Mixed Models

    PubMed Central

    Zhu, Hongxiao; Caspers, Philip; Morris, Jeffrey S.; Wu, Xiaowei; Müller, Rolf

    2017-01-01

    Sonar emits pulses of sound and uses the reflected echoes to gain information about target objects. It offers a low cost, complementary sensing modality for small robotic platforms. While existing analytical approaches often assume independence across echoes, real sonar data can have more complicated structures due to device setup or experimental design. In this paper, we consider sonar echo data collected from multiple terrain substrates with a dual-channel sonar head. Our goals are to identify the differential sonar responses to terrains and study the effectiveness of this dual-channel design in discriminating targets. We describe a unified analytical framework that achieves these goals rigorously, simultaneously, and automatically. The analysis was done by treating the echo envelope signals as functional responses and the terrain/channel information as covariates in a functional regression setting. We adopt functional mixed models that facilitate the estimation of terrain and channel effects while capturing the complex hierarchical structure in data. This unified analytical framework incorporates both Gaussian models and robust models. We fit the models using a full Bayesian approach, which enables us to perform multiple inferential tasks under the same modeling framework, including selecting models, estimating the effects of interest, identifying significant local regions, discriminating terrain types, and describing the discriminatory power of local regions. Our analysis of the sonar-terrain data identifies time regions that reflect differential sonar responses to terrains. The discriminant analysis suggests that a multi- or dual-channel design achieves target identification performance comparable with or better than a single-channel design. PMID:29749977

  4. Quantum-gravity predictions for the fine-structure constant

    NASA Astrophysics Data System (ADS)

    Eichhorn, Astrid; Held, Aaron; Wetterich, Christof

    2018-07-01

    Asymptotically safe quantum fluctuations of gravity can uniquely determine the value of the gauge coupling for a large class of grand unified models. In turn, this makes the electromagnetic fine-structure constant calculable. The balance of gravity and matter fluctuations results in a fixed point for the running of the gauge coupling. It is approached as the momentum scale is lowered in the transplanckian regime, leading to a uniquely predicted value of the gauge coupling at the Planck scale. The precise value of the predicted fine-structure constant depends on the matter content of the grand unified model. It is proportional to the gravitational fluctuation effects for which computational uncertainties remain to be settled.

  5. CONTINUITY OF AXES I AND II: TOWARD A UNIFIED MODEL OF PERSONALITY, PERSONALITY DISORDERS, AND CLINICAL DISORDERS

    PubMed Central

    Krueger, Robert F.

    2008-01-01

    In the current standard psychiatric nomenclature, the DSM–IV–TR (APA, 2000), mental disorders are divided into two groups: Clinical Disorders (CDs) and Personality Disorders (PDs), and CD and PD diagnoses are recorded on two separate axes (Axes I and II, respectively). This article considers evidence regarding putative bases for distinguishing between CDs and PDs, and finds that these constructs are more similar than distinct. Links between the domains may be better understood by focusing on how personality connects CDs and PDs. This perspective underlines the need to work toward a more unified model of personality, PDs, and CDs in research and in future editions of the DSM. PMID:16175735

  6. A Unified Model of Geostrophic Adjustment and Frontogenesis

    NASA Astrophysics Data System (ADS)

    Taylor, John; Shakespeare, Callum

    2013-11-01

    Fronts, or regions with strong horizontal density gradients, are ubiquitous and dynamically important features of the ocean and atmosphere. In the ocean, fronts are associated with enhanced air-sea fluxes, turbulence, and biological productivity, while atmospheric fronts are associated with some of the most extreme weather events. Here, we describe a new mathematical framework for describing the formation of fronts, or frontogenesis. This framework unifies two classical problems in geophysical fluid dynamics, geostrophic adjustment and strain-driven frontogenesis, and provides a number of important extensions beyond previous efforts. The model solutions closely match numerical simulations during the early stages of frontogenesis, and provide a means to describe the development of turbulence at mature fronts.

  7. Integrating diverse databases into an unified analysis framework: a Galaxy approach

    PubMed Central

    Blankenberg, Daniel; Coraor, Nathan; Von Kuster, Gregory; Taylor, James; Nekrutenko, Anton

    2011-01-01

    Recent technological advances have lead to the ability to generate large amounts of data for model and non-model organisms. Whereas, in the past, there have been a relatively small number of central repositories that serve genomic data, an increasing number of distinct specialized data repositories and resources have been established. Here, we describe a generic approach that provides for the integration of a diverse spectrum of data resources into a unified analysis framework, Galaxy (http://usegalaxy.org). This approach allows the simplified coupling of external data resources with the data analysis tools available to Galaxy users, while leveraging the native data mining facilities of the external data resources. Database URL: http://usegalaxy.org PMID:21531983

  8. Reconceptualizing Social Influence in Counseling: The Elaboration Likelihood Model.

    ERIC Educational Resources Information Center

    McNeill, Brian W.; Stoltenberg, Cal D.

    1989-01-01

    Presents Elaboration Likelihood Model (ELM) of persuasion (a reconceptualization of the social influence process) as alternative model of attitude change. Contends ELM unifies conflicting social psychology results and can potentially account for inconsistent research findings in counseling psychology. Provides guidelines on integrating…

  9. BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.

    PubMed

    Ambrosini, Grazia; Sawle, Ashley D; Musi, Elgilda; Schwartz, Gary K

    2015-10-20

    Uveal melanoma (UM) is an aggressive intraocular malignancy with limited therapeutic options. Both primary and metastatic UM are characterized by oncogenic mutations in the G-protein alpha subunit q and 11. Furthermore, nearly 40% of UM has amplification of the chromosomal arm 8q and monosomy of chromosome 3, with consequent anomalies of MYC copy number. Chromatin regulators have become attractive targets for cancer therapy. In particular, the bromodomain and extra-terminal (BET) inhibitor JQ1 has shown selective inhibition of c-Myc expression with antiproliferative activity in hematopoietic and solid tumors. Here we provide evidence that JQ1 had cytotoxic activity in UM cell lines carrying Gnaq/11 mutations, while in cells without the mutations had little effects. Using microarray analysis, we identified a large subset of genes modulated by JQ1 involved in the regulation of cell cycle, apoptosis and DNA repair. Further analysis of selected genes determined that the concomitant silencing of Bcl-xL and Rad51 represented the minimal requirement to mimic the apoptotic effects of JQ1 in the mutant cells, independently of c-Myc. In addition, administration of JQ1 to mouse xenograft models of Gnaq-mutant UM resulted in significant inhibition of tumor growth.Collectively, our results define BRD4 targeting as a novel therapeutic intervention against UM with Gnaq/Gna11 mutations.

  10. CMB-galaxy correlation in Unified Dark Matter scalar field cosmologies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bertacca, Daniele; Bartolo, Nicola; Matarrese, Sabino

    We present an analysis of the cross-correlation between the CMB and the large-scale structure (LSS) of the Universe in Unified Dark Matter (UDM) scalar field cosmologies. We work out the predicted cross-correlation function in UDM models, which depends on the speed of sound of the unified component, and compare it with observations from six galaxy catalogues (NVSS, HEAO, 2MASS, and SDSS main galaxies, luminous red galaxies, and quasars). We sample the value of the speed of sound and perform a likelihood analysis, finding that the UDM model is as likely as the ΛCDM, and is compatible with observations for amore » range of values of c{sub ∞} (the value of the sound speed at late times) on which structure formation depends. In particular, we obtain an upper bound of c{sub ∞}{sup 2} ≤ 0.009 at 95% confidence level, meaning that the ΛCDM model, for which c{sub ∞}{sup 2} = 0, is a good fit to the data, while the posterior probability distribution peaks at the value c{sub ∞}{sup 2} = 10{sup −4} . Finally, we study the time dependence of the deviation from ΛCDM via a tomographic analysis using a mock redshift distribution and we find that the largest deviation is for low-redshift sources, suggesting that future low-z surveys will be best suited to constrain UDM models.« less

  11. Investigation of the HLA component involved in rheumatoid arthritis (RA) by using the marker association-segregation [chi][sup 2] (MASC) method: Rejection of the unifying-shared-epitope hypothesis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dizier, M.H.; Eliaou, J.F.; Babron, M.C.

    In order to investigate the HLA component involved in rheumatoid arthritis (RA), the authors tested genetic models by the marker association-segregation [chi][sup 2] (MASC) method, using the HLA genotypic distribution observed in a sample of 97 RA patients. First they tested models assuming the involvement of a susceptibility gene linked to the DR locus. They showed that the present data are compatible with a simple model assuming the effect of a recessive allele of a biallelic locus linked to the DR locus and without any assumption of synergistic effect. Then they considered models assuming the direct involvement of the DRmore » allele products, and tested the unifying-shared-epitope hypothesis, which has been proposed. Under this hypothesis the DR alleles are assumed to be directly involved in the susceptibility to the disease because of the presence of similar or identical amino acid sequences in position 70-74 of the third hypervariable region of the DRBI molecules, shared by the RA-associated DR alleles DR4Dw4, DR4Dw14, and DR1. This hypothesis was strongly rejected with the present data. In the case of the direct involvement of the DR alleles, hypotheses more complex that the unifying-shared-epitope hypothesis would have to be considered. 28 refs., 2 tabs.« less

  12. An Uncertainty Structure Matrix for Models and Simulations

    NASA Technical Reports Server (NTRS)

    Green, Lawrence L.; Blattnig, Steve R.; Hemsch, Michael J.; Luckring, James M.; Tripathi, Ram K.

    2008-01-01

    Software that is used for aerospace flight control and to display information to pilots and crew is expected to be correct and credible at all times. This type of software is typically developed under strict management processes, which are intended to reduce defects in the software product. However, modeling and simulation (M&S) software may exhibit varying degrees of correctness and credibility, depending on a large and complex set of factors. These factors include its intended use, the known physics and numerical approximations within the M&S, and the referent data set against which the M&S correctness is compared. The correctness and credibility of an M&S effort is closely correlated to the uncertainty management (UM) practices that are applied to the M&S effort. This paper describes an uncertainty structure matrix for M&S, which provides a set of objective descriptions for the possible states of UM practices within a given M&S effort. The columns in the uncertainty structure matrix contain UM elements or practices that are common across most M&S efforts, and the rows describe the potential levels of achievement in each of the elements. A practitioner can quickly look at the matrix to determine where an M&S effort falls based on a common set of UM practices that are described in absolute terms that can be applied to virtually any M&S effort. The matrix can also be used to plan those steps and resources that would be needed to improve the UM practices for a given M&S effort.

  13. A unified bond theory, probabilistic meso-scale modeling, and experimental validation of deformed steel rebar in normal strength concrete

    NASA Astrophysics Data System (ADS)

    Wu, Chenglin

    Bond between deformed rebar and concrete is affected by rebar deformation pattern, concrete properties, concrete confinement, and rebar-concrete interfacial properties. Two distinct groups of bond models were traditionally developed based on the dominant effects of concrete splitting and near-interface shear-off failures. Their accuracy highly depended upon the test data sets selected in analysis and calibration. In this study, a unified bond model is proposed and developed based on an analogy to the indentation problem around the rib front of deformed rebar. This mechanics-based model can take into account the combined effect of concrete splitting and interface shear-off failures, resulting in average bond strengths for all practical scenarios. To understand the fracture process associated with bond failure, a probabilistic meso-scale model of concrete is proposed and its sensitivity to interface and confinement strengths are investigated. Both the mechanical and finite element models are validated with the available test data sets and are superior to existing models in prediction of average bond strength (< 6% error) and crack spacing (< 6% error). The validated bond model is applied to derive various interrelations among concrete crushing, concrete splitting, interfacial behavior, and the rib spacing-to-height ratio of deformed rebar. It can accurately predict the transition of failure modes from concrete splitting to rebar pullout and predict the effect of rebar surface characteristics as the rib spacing-to-height ratio increases. Based on the unified theory, a global bond model is proposed and developed by introducing bond-slip laws, and validated with testing of concrete beams with spliced reinforcement, achieving a load capacity prediction error of less than 26%. The optimal rebar parameters and concrete cover in structural designs can be derived from this study.

  14. Expeditionary Learning Approach in Integrated Teacher Education: Model Effectiveness and Dilemma.

    ERIC Educational Resources Information Center

    Hyun, Eunsook

    This paper introduces an integrated teacher education model based on the Expeditionary Learning Outward Bound Project model. It integrates early childhood, elementary, and special education and uses inquiry-oriented and social constructive approaches. It models a team approach, with all teachers unified in their mutually shared philosophy of…

  15. Robustness of Hierarchical Modeling of Skill Association in Cognitive Diagnosis Models

    ERIC Educational Resources Information Center

    Templin, Jonathan L.; Henson, Robert A.; Templin, Sara E.; Roussos, Louis

    2008-01-01

    Several types of parameterizations of attribute correlations in cognitive diagnosis models use the reduced reparameterized unified model. The general approach presumes an unconstrained correlation matrix with K(K - 1)/2 parameters, whereas the higher order approach postulates K parameters, imposing a unidimensional structure on the correlation…

  16. Integrating Incremental Learning and Episodic Memory Models of the Hippocampal Region

    ERIC Educational Resources Information Center

    Meeter, M.; Myers, C. E.; Gluck, M. A.

    2005-01-01

    By integrating previous computational models of corticohippocampal function, the authors develop and test a unified theory of the neural substrates of familiarity, recollection, and classical conditioning. This approach integrates models from 2 traditions of hippocampal modeling, those of episodic memory and incremental learning, by drawing on an…

  17. SO(10) supersymmetric grand unified theories

    NASA Astrophysics Data System (ADS)

    Dermisek, Radovan

    The origin of the fermion mass hierarchy is one of the most challenging problems in elementary particle physics. In the standard model fermion masses and mixing angles are free parameters. Supersymmetric grand unified theories provide a beautiful framework for physics beyond the standard model. In addition to gauge coupling unification these theories provide relations between quark and lepton masses within families, and with additional family symmetry the hierarchy between families can be generated. We present a predictive SO(10) supersymmetric grand unified model with D 3 x U(1) family symmetry. The hierarchy in fermion masses is generated by the family symmetry breaking D 3 x U(1) → ZN → nothing. This model fits the low energy data in the charged fermion sector quite well. We discuss the prediction of this model for the proton lifetime in light of recent SuperKamiokande results and present a clear picture of the allowed spectra of supersymmetric particles. Finally, the detailed discussion of the Yukawa coupling unification of the third generation particles is provided. We find a narrow region is consistent with t, b, tau Yukawa unification for mu > 0 (suggested by b → sgamma and the anomalous magnetic moment of the muon) with A0 ˜ -1.9m16, m10 ˜ 1.4m16, m16 ≳ 1200 GeV and mu, M1/2 ˜ 100--500 GeV. Demanding Yukawa unification thus makes definite predictions for Higgs and sparticle masses.

  18. Why is metal bioaccumulation so variable? Biodynamics as a unifying concept

    USGS Publications Warehouse

    Luoma, Samuel N.; Rainbow, Philip S.

    2005-01-01

    Ecological risks from metal contaminants are difficult to document because responses differ among species, threats differ among metals, and environmental influences are complex. Unifying concepts are needed to better tie together such complexities. Here we suggest that a biologically based conceptualization, the biodynamic model, provides the necessary unification for a key aspect in risk:  metal bioaccumulation (internal exposure). The model is mechanistically based, but empirically considers geochemical influences, biological differences, and differences among metals. Forecasts from the model agree closely with observations from nature, validating its basic assumptions. The biodynamic metal bioaccumulation model combines targeted, high-quality geochemical analyses from a site of interest with parametrization of key physiological constants for a species from that site. The physiological parameters include metal influx rates from water, influx rates from food, rate constants of loss, and growth rates (when high). We compiled results from 15 publications that forecast species-specific bioaccumulation, and compare the forecasts to bioaccumulation data from the field. These data consider concentrations that cover 7 orders of magnitude. They include 7 metals and 14 species of animals from 3 phyla and 11 marine, estuarine, and freshwater environments. The coefficient of determination (R2) between forecasts and independently observed bioaccumulation from the field was 0.98. Most forecasts agreed with observations within 2-fold. The agreement suggests that the basic assumptions of the biodynamic model are tenable. A unified explanation of metal bioaccumulation sets the stage for a realistic understanding of toxicity and ecological effects of metals in nature.

  19. A unified account of perceptual layering and surface appearance in terms of gamut relativity.

    PubMed

    Vladusich, Tony; McDonnell, Mark D

    2014-01-01

    When we look at the world--or a graphical depiction of the world--we perceive surface materials (e.g. a ceramic black and white checkerboard) independently of variations in illumination (e.g. shading or shadow) and atmospheric media (e.g. clouds or smoke). Such percepts are partly based on the way physical surfaces and media reflect and transmit light and partly on the way the human visual system processes the complex patterns of light reaching the eye. One way to understand how these percepts arise is to assume that the visual system parses patterns of light into layered perceptual representations of surfaces, illumination and atmospheric media, one seen through another. Despite a great deal of previous experimental and modelling work on layered representation, however, a unified computational model of key perceptual demonstrations is still lacking. Here we present the first general computational model of perceptual layering and surface appearance--based on a boarder theoretical framework called gamut relativity--that is consistent with these demonstrations. The model (a) qualitatively explains striking effects of perceptual transparency, figure-ground separation and lightness, (b) quantitatively accounts for the role of stimulus- and task-driven constraints on perceptual matching performance, and (c) unifies two prominent theoretical frameworks for understanding surface appearance. The model thereby provides novel insights into the remarkable capacity of the human visual system to represent and identify surface materials, illumination and atmospheric media, which can be exploited in computer graphics applications.

  20. A Unified Account of Perceptual Layering and Surface Appearance in Terms of Gamut Relativity

    PubMed Central

    Vladusich, Tony; McDonnell, Mark D.

    2014-01-01

    When we look at the world—or a graphical depiction of the world—we perceive surface materials (e.g. a ceramic black and white checkerboard) independently of variations in illumination (e.g. shading or shadow) and atmospheric media (e.g. clouds or smoke). Such percepts are partly based on the way physical surfaces and media reflect and transmit light and partly on the way the human visual system processes the complex patterns of light reaching the eye. One way to understand how these percepts arise is to assume that the visual system parses patterns of light into layered perceptual representations of surfaces, illumination and atmospheric media, one seen through another. Despite a great deal of previous experimental and modelling work on layered representation, however, a unified computational model of key perceptual demonstrations is still lacking. Here we present the first general computational model of perceptual layering and surface appearance—based on a boarder theoretical framework called gamut relativity—that is consistent with these demonstrations. The model (a) qualitatively explains striking effects of perceptual transparency, figure-ground separation and lightness, (b) quantitatively accounts for the role of stimulus- and task-driven constraints on perceptual matching performance, and (c) unifies two prominent theoretical frameworks for understanding surface appearance. The model thereby provides novel insights into the remarkable capacity of the human visual system to represent and identify surface materials, illumination and atmospheric media, which can be exploited in computer graphics applications. PMID:25402466

  1. Steepest entropy ascent model for far-nonequilibrium thermodynamics: Unified implementation of the maximum entropy production principle

    NASA Astrophysics Data System (ADS)

    Beretta, Gian Paolo

    2014-10-01

    By suitable reformulations, we cast the mathematical frameworks of several well-known different approaches to the description of nonequilibrium dynamics into a unified formulation valid in all these contexts, which extends to such frameworks the concept of steepest entropy ascent (SEA) dynamics introduced by the present author in previous works on quantum thermodynamics. Actually, the present formulation constitutes a generalization also for the quantum thermodynamics framework. The analysis emphasizes that in the SEA modeling principle a key role is played by the geometrical metric with respect to which to measure the length of a trajectory in state space. In the near-thermodynamic-equilibrium limit, the metric tensor is directly related to the Onsager's generalized resistivity tensor. Therefore, through the identification of a suitable metric field which generalizes the Onsager generalized resistance to the arbitrarily far-nonequilibrium domain, most of the existing theories of nonequilibrium thermodynamics can be cast in such a way that the state exhibits the spontaneous tendency to evolve in state space along the path of SEA compatible with the conservation constraints and the boundary conditions. The resulting unified family of SEA dynamical models is intrinsically and strongly consistent with the second law of thermodynamics. The non-negativity of the entropy production is a general and readily proved feature of SEA dynamics. In several of the different approaches to nonequilibrium description we consider here, the SEA concept has not been investigated before. We believe it defines the precise meaning and the domain of general validity of the so-called maximum entropy production principle. Therefore, it is hoped that the present unifying approach may prove useful in providing a fresh basis for effective, thermodynamically consistent, numerical models and theoretical treatments of irreversible conservative relaxation towards equilibrium from far nonequilibrium states. The mathematical frameworks we consider are the following: (A) statistical or information-theoretic models of relaxation; (B) small-scale and rarefied gas dynamics (i.e., kinetic models for the Boltzmann equation); (C) rational extended thermodynamics, macroscopic nonequilibrium thermodynamics, and chemical kinetics; (D) mesoscopic nonequilibrium thermodynamics, continuum mechanics with fluctuations; and (E) quantum statistical mechanics, quantum thermodynamics, mesoscopic nonequilibrium quantum thermodynamics, and intrinsic quantum thermodynamics.

  2. Benefits of a Unified LaSRS++ Simulation for NAS-Wide and High-Fidelity Modeling

    NASA Technical Reports Server (NTRS)

    Glaab, Patricia; Madden, Michael

    2014-01-01

    The LaSRS++ high-fidelity vehicle simulation was extended in 2012 to support a NAS-wide simulation mode. Since the initial proof-of-concept, the LaSRS++ NAS-wide simulation is maturing into a research-ready tool. A primary benefit of this new capability is the consolidation of the two modeling paradigms under a single framework to save cost, facilitate iterative concept testing between the two tools, and to promote communication and model sharing between user communities at Langley. Specific benefits of each type of modeling are discussed along with the expected benefits of the unified framework. Current capability details of the LaSRS++ NAS-wide simulations are provided, including the visualization tool, live data interface, trajectory generators, terminal routing for arrivals and departures, maneuvering, re-routing, navigation, winds, and turbulence. The plan for future development is also described.

  3. Biomass transformation webs provide a unified approach to consumer–resource modelling

    PubMed Central

    Getz, Wayne M.

    2011-01-01

    An approach to modelling food web biomass flows among live and dead compartments within and among species is formulated using metaphysiological principles that characterise population growth in terms of basal metabolism, feeding, senescence and exploitation. This leads to a unified approach to modelling interactions among plants, herbivores, carnivores, scavengers, parasites and their resources. Also, dichotomising sessile miners from mobile gatherers of resources, with relevance to feeding and starvation time scales, suggests a new classification scheme involving 10 primary categories of consumer types. These types, in various combinations, rigorously distinguish scavenger from parasite, herbivory from phytophagy and detritivore from decomposer. Application of the approach to particular consumer–resource interactions is demonstrated, culminating in the construction of an anthrax-centred food web model, with parameters applicable to Etosha National Park, Namibia, where deaths of elephants and zebra from the bacterial pathogen, Bacillus anthracis, provide significant subsidies to jackals, vultures and other scavengers. PMID:21199247

  4. Some characteristics of supernetworks based on unified hybrid network theory framework

    NASA Astrophysics Data System (ADS)

    Liu, Qiang; Fang, Jin-Qing; Li, Yong

    Comparing with single complex networks, supernetworks are more close to the real world in some ways, and have become the newest research hot spot in the network science recently. Some progresses have been made in the research of supernetworks, but the theoretical research method and complex network characteristics of supernetwork models are still needed to further explore. In this paper, we propose three kinds of supernetwork models with three layers based on the unified hybrid network theory framework (UHNTF), and introduce preferential and random linking, respectively, between the upper and lower layers. Then we compared the topological characteristics of the single networks with the supernetwork models. In order to analyze the influence of the interlayer edges on network characteristics, the cross-degree is defined as a new important parameter. Then some interesting new phenomena are found, the results imply this supernetwork model has reference value and application potential.

  5. Snoopy--a unifying Petri net framework to investigate biomolecular networks.

    PubMed

    Rohr, Christian; Marwan, Wolfgang; Heiner, Monika

    2010-04-01

    To investigate biomolecular networks, Snoopy provides a unifying Petri net framework comprising a family of related Petri net classes. Models can be hierarchically structured, allowing for the mastering of larger networks. To move easily between the qualitative, stochastic and continuous modelling paradigms, models can be converted into each other. We get models sharing structure, but specialized by their kinetic information. The analysis and iterative reverse engineering of biomolecular networks is supported by the simultaneous use of several Petri net classes, while the graphical user interface adapts dynamically to the active one. Built-in animation and simulation are complemented by exports to various analysis tools. Snoopy facilitates the addition of new Petri net classes thanks to its generic design. Our tool with Petri net samples is available free of charge for non-commercial use at http://www-dssz.informatik.tu-cottbus.de/snoopy.html; supported operating systems: Mac OS X, Windows and Linux (selected distributions).

  6. Unified computational model of transport in metal-insulating oxide-metal systems

    NASA Astrophysics Data System (ADS)

    Tierney, B. D.; Hjalmarson, H. P.; Jacobs-Gedrim, R. B.; Agarwal, Sapan; James, C. D.; Marinella, M. J.

    2018-04-01

    A unified physics-based model of electron transport in metal-insulator-metal (MIM) systems is presented. In this model, transport through metal-oxide interfaces occurs by electron tunneling between the metal electrodes and oxide defect states. Transport in the oxide bulk is dominated by hopping, modeled as a series of tunneling events that alter the electron occupancy of defect states. Electron transport in the oxide conduction band is treated by the drift-diffusion formalism and defect chemistry reactions link all the various transport mechanisms. It is shown that the current-limiting effect of the interface band offsets is a function of the defect vacancy concentration. These results provide insight into the underlying physical mechanisms of leakage currents in oxide-based capacitors and steady-state electron transport in resistive random access memory (ReRAM) MIM devices. Finally, an explanation of ReRAM bipolar switching behavior based on these results is proposed.

  7. Apollo experience report: S-band system signal design and analysis

    NASA Technical Reports Server (NTRS)

    Rosenberg, H. R. (Editor)

    1972-01-01

    A description is given of the Apollo communications-system engineering-analysis effort that ensured the adequacy, performance, and interface compatibility of the unified S-band system elements for a successful lunar-landing mission. The evolution and conceptual design of the unified S-band system are briefly reviewed from a historical viewpoint. A comprehensive discussion of the unified S-band elements includes the salient design features of the system and serves as a basis for a better understanding of the design decisions and analyses. The significant design decisions concerning the Apollo communications-system signal design are discussed providing an insight into the role of systems analysis in arriving at the current configuration of the Apollo communications system. Analyses are presented concerning performance estimation (mathematical-model development through real-time mission support) and system deficiencies, modifications, and improvements.

  8. Impact of Tile Drainage on the Distribution of Concentration and Age of Inorganic Soil Nitrogen.

    NASA Astrophysics Data System (ADS)

    Woo, D.; Kumar, P.

    2017-12-01

    Extensive network of tile drainage network across the Midwestern United States, northern Europe and other regions of the world have enhanced agricultural productivity. Because of its impact on sub-surface flow patterns and moisture and temperature dynamics, it controls the nitrogen cycle in agricultural systems, and its influence on nitrogen dynamics plays a key role in determining the short- and long-term evolution of soil inorganic nitrogen concentration and age. The spatial mapping of nitrogen concentration and age under tile-drained fields has, therefore, the potential to open up novel solution to the vexing challenge of reducing environmental impacts while at the same time maintaining agricultural productivity. The objective of this study is to explore the impacts of tile drains on the age dynamics of nitrate, immobile ammonium, mobile ammonia/um, and non-reactive tracer (such as chloride) by implementing two mobile interacting pore domains to capture matrix and preferential flow paths in a coupled ecohydrology and biogeochemistry model, Dhara. We applied this model to an agricultural farm supporting a corn-soybean rotation in the Midwestern United States. It should be expected that the installation of tile drains decrease the age of soil nutrient due to nutrient losses through tile drainage. However, an increase in the age of mobile ammonia/um is observed in contrast to the cases for nitrate, immobile ammonium, and non-reactive tracer. These results arise because the depletion of mobile ammonia/um due to tile drainage causes a high mobility flux from immobile ammonium to mobile ammonia/um, which also carries a considerable amount of relatively old age of immobile ammonium to mobile ammonia/um. In addition, the ages of nitrate and mobile ammonia/um in tile drainage range from 1 to 3 years, and less than a year, respectively, implying that not considering age transformations between nitrogen species would result in substantial underestimation of nitrogen ages, possibly leading to an erroneous conclusion.

  9. NED-IIS: An Intelligent Information System for Forest Ecosystem Management

    Treesearch

    W.D. Potter; S. Somasekar; R. Kommineni; H.M. Rauscher

    1999-01-01

    We view Intelligent Information System (IIS) as composed of a unified knowledge base, database, and model base. The model base includes decision support models, forecasting models, and cvsualization models for example. In addition, we feel that the model base should include domain specific porblems solving modules as well as decision support models. This, then,...

  10. In Search of Optimal Cognitive Diagnostic Model(s) for ESL Grammar Test Data

    ERIC Educational Resources Information Center

    Yi, Yeon-Sook

    2017-01-01

    This study compares five cognitive diagnostic models in search of optimal one(s) for English as a Second Language grammar test data. Using a unified modeling framework that can represent specific models with proper constraints, the article first fit the full model (the log-linear cognitive diagnostic model, LCDM) and investigated which model…

  11. Examples of EOS Variables as compared to the UMM-Var Data Model

    NASA Technical Reports Server (NTRS)

    Cantrell, Simon; Lynnes, Chris

    2016-01-01

    In effort to provide EOSDIS clients a way to discover and use variable data from different providers, a Unified Metadata Model for Variables is being created. This presentation gives an overview of the model and use cases we are handling.

  12. On the Performance Characteristics of Latent-Factor and Knowledge Tracing Models

    ERIC Educational Resources Information Center

    Klingler, Severin; Käser, Tanja; Solenthaler, Barbara; Gross, Markus

    2015-01-01

    Modeling student knowledge is a fundamental task of an intelligent tutoring system. A popular approach for modeling the acquisition of knowledge is Bayesian Knowledge Tracing (BKT). Various extensions to the original BKT model have been proposed, among them two novel models that unify BKT and Item Response Theory (IRT). Latent Factor Knowledge…

  13. SENSITIVITY OF OZONE AND AEROSOL PREDICTIONS TO THE TRANSPORT ALGORITHMS IN THE MODELS-3 COMMUNITY MULTI-SCALE AIR QUALITY (CMAQ) MODELING SYSTEM

    EPA Science Inventory

    EPA's Models-3 CMAQ system is intended to provide a community modeling paradigm that allows continuous improvement of the one-atmosphere modeling capability in a unified fashion. CMAQ's modular design promotes incorporation of several sets of science process modules representing ...

  14. Examination of Modeling Languages to Allow Quantitative Analysis for Model-Based Systems Engineering

    DTIC Science & Technology

    2014-06-01

    x THIS PAGE INTENTIONALLY LEFT BLANK xi LIST OF ACRONYMS AND ABBREVIATIONS BOM Base Object Model BPMN Business Process Model & Notation DOD...SysML. There are many variants such as the Unified Profile for DODAF/MODAF (UPDM) and Business Process Model & Notation ( BPMN ) that have origins in

  15. Risk stratification for death and all-cause hospitalization in heart failure clinic outpatients.

    PubMed

    Hummel, Scott L; Ghalib, Hussam H; Ratz, David; Koelling, Todd M

    2013-11-01

    Most heart failure (HF) risk stratification models were developed for inpatient use, and available outpatient models use a complex set of variables. We hypothesized that routinely collected clinical data could predict the 6-month risk of death and all-cause medical hospitalization in HF clinic outpatients. Using a quality improvement database and multivariable Cox modeling, we derived the Heart Failure Patient Severity Index (HFPSI) in the University of Michigan HF clinic (UM cohort, n = 1,536; 314 reached primary outcome). We externally validated the HFPSI in the Ann Arbor Veterans' Affairs HF clinic (VA cohort, n = 445; 106 outcomes) and explored "real-time" HFPSI use (VA-RT cohort, n = 486; 141 outcomes) by tracking VA patients for 6 months from their most recently calculated HFPSI, rather than using an arbitrary start date for the cohort. The HFPSI model included blood urea nitrogen, B-type natriuretic peptide, New York Heart Association class, diabetes status, history of atrial fibrillation/flutter, and all-cause hospitalization within the prior 1 and 2 to 6 months. The concordance c statistics in the UM/VA/VA-RT cohorts were 0.71/0.68/0.74. Kaplan-Meier curves and log-rank testing demonstrated excellent risk stratification, particularly between a large, low-risk group (40% of patients, 6-month event rates in the UM/VA/VA-RT cohorts 8%/12%/12%) and a small, high-risk group (10% of patients, 6-month event rates in the UM/VA/VA-RT cohorts 57%/58%/79%). The HFPSI uses readily available data to predict the 6-month risk of death and/or all-cause medical hospitalization in HF clinic outpatients and could potentially help allocate specialized HF resources within health systems. © 2013.

  16. Integrating Unified Gravity Wave Physics into the NOAA Next Generation Global Prediction System

    NASA Astrophysics Data System (ADS)

    Alpert, J. C.; Yudin, V.; Fuller-Rowell, T. J.; Akmaev, R. A.

    2017-12-01

    The Unified Gravity Wave Physics (UGWP) project for the Next Generation Global Prediction System (NGGPS) is a NOAA collaborative effort between the National Centers for Environmental Prediction (NCEP), Environemntal Modeling Center (EMC) and the University of Colorado, Cooperative Institute for Research in Environmental Sciences (CU-CIRES) to support upgrades and improvements of GW dynamics (resolved scales) and physics (sub-grid scales) in the NOAA Environmental Modeling System (NEMS)†. As envisioned the global climate, weather and space weather models of NEMS will substantially improve their predictions and forecasts with the resolution-sensitive (scale-aware) formulations planned under the UGWP framework for both orographic and non-stationary waves. In particular, the planned improvements for the Global Forecast System (GFS) model of NEMS are: calibration of model physics for higher vertical and horizontal resolution and an extended vertical range of simulations, upgrades to GW schemes, including the turbulent heating and eddy mixing due to wave dissipation and breaking, and representation of the internally-generated QBO. The main priority of the UGWP project is unified parameterization of orographic and non-orographic GW effects including momentum deposition in the middle atmosphere and turbulent heating and eddies due to wave dissipation and breaking. The latter effects are not currently represented in NOAA atmosphere models. The team has tested and evaluated four candidate GW solvers integrating the selected GW schemes into the NGGPS model. Our current work and planned activity is to implement the UGWP schemes in the first available GFS/FV3 (open FV3) configuration including adapted GFDL modification for sub-grid orography in GFS. Initial global model results will be shown for the operational and research GFS configuration for spectral and FV3 dynamical cores. †http://www.emc.ncep.noaa.gov/index.php?branch=NEMS

  17. Advances in the U.S. Navy Non-hydrostatic Unified Model of the Atmosphere (NUMA): LES as a Stabilization Methodology for High-Order Spectral Elements in the Simulation of Deep Convection

    NASA Astrophysics Data System (ADS)

    Marras, Simone; Giraldo, Frank

    2015-04-01

    The prediction of extreme weather sufficiently ahead of its occurrence impacts society as a whole and coastal communities specifically (e.g. Hurricane Sandy that impacted the eastern seaboard of the U.S. in the fall of 2012). With the final goal of solving hurricanes at very high resolution and numerical accuracy, we have been developing the Non-hydrostatic Unified Model of the Atmosphere (NUMA) to solve the Euler and Navier-Stokes equations by arbitrary high-order element-based Galerkin methods on massively parallel computers. NUMA is a unified model with respect to the following criteria: (a) it is based on unified numerics in that element-based Galerkin methods allow the user to choose between continuous (spectral elements, CG) or discontinuous Galerkin (DG) methods and from a large spectrum of time integrators, (b) it is unified across scales in that it can solve flow in limited-area mode (flow in a box) or in global mode (flow on the sphere). NUMA is the dynamical core that powers the U.S. Naval Research Laboratory's next-generation global weather prediction system NEPTUNE (Navy's Environmental Prediction sysTem Utilizing the NUMA corE). Because the solution of the Euler equations by high order methods is prone to instabilities that must be damped in some way, we approach the problem of stabilization via an adaptive Large Eddy Simulation (LES) scheme meant to treat such instabilities by modeling the sub-grid scale features of the flow. The novelty of our effort lies in the extension to high order spectral elements for low Mach number stratified flows of a method that was originally designed for low order, adaptive finite elements in the high Mach number regime [1]. The Euler equations are regularized by means of a dynamically adaptive stress tensor that is proportional to the residual of the unperturbed equations. Its effect is close to none where the solution is sufficiently smooth, whereas it increases elsewhere, with a direct contribution to the stabilization of the otherwise oscillatory solution. As a first step toward the Large Eddy Simulation of a hurricane, we verify the model via a high-order and high resolution idealized simulation of deep convection on the sphere. References [1] M. Nazarov and J. Hoffman (2013) Residual-based artificial viscosity for simulation of turbulent compressible flow using adaptive finite element methods Int. J. Numer. Methods Fluids, 71:339-357

  18. Short-Range Prediction of Monsoon Precipitation by NCMRWF Regional Unified Model with Explicit Convection

    NASA Astrophysics Data System (ADS)

    Mamgain, Ashu; Rajagopal, E. N.; Mitra, A. K.; Webster, S.

    2018-03-01

    There are increasing efforts towards the prediction of high-impact weather systems and understanding of related dynamical and physical processes. High-resolution numerical model simulations can be used directly to model the impact at fine-scale details. Improvement in forecast accuracy can help in disaster management planning and execution. National Centre for Medium Range Weather Forecasting (NCMRWF) has implemented high-resolution regional unified modeling system with explicit convection embedded within coarser resolution global model with parameterized convection. The models configurations are based on UK Met Office unified seamless modeling system. Recent land use/land cover data (2012-2013) obtained from Indian Space Research Organisation (ISRO) are also used in model simulations. Results based on short-range forecast of both the global and regional models over India for a month indicate that convection-permitting simulations by the high-resolution regional model is able to reduce the dry bias over southern parts of West Coast and monsoon trough zone with more intense rainfall mainly towards northern parts of monsoon trough zone. Regional model with explicit convection has significantly improved the phase of the diurnal cycle of rainfall as compared to the global model. Results from two monsoon depression cases during study period show substantial improvement in details of rainfall pattern. Many categories in rainfall defined for operational forecast purposes by Indian forecasters are also well represented in case of convection-permitting high-resolution simulations. For the statistics of number of days within a range of rain categories between `No-Rain' and `Heavy Rain', the regional model is outperforming the global model in all the ranges. In the very heavy and extremely heavy categories, the regional simulations show overestimation of rainfall days. Global model with parameterized convection have tendency to overestimate the light rainfall days and underestimate the heavy rain days compared to the observation data.

  19. Modeling winter wheat phenological responses to water deficits in the Unified Plant Growth Model (UPGM) component of the spatially distributed Agricultural Ecosystem Services (AgES) model

    USDA-ARS?s Scientific Manuscript database

    Accurately predicting phenology in crop simulation models is critical for correctly simulating crop production. While extensive work in modeling phenology has focused on the temperature response function (resulting in robust phenology models), limited work on quantifying the phenological responses t...

  20. Nonlinear Hebbian Learning as a Unifying Principle in Receptive Field Formation.

    PubMed

    Brito, Carlos S N; Gerstner, Wulfram

    2016-09-01

    The development of sensory receptive fields has been modeled in the past by a variety of models including normative models such as sparse coding or independent component analysis and bottom-up models such as spike-timing dependent plasticity or the Bienenstock-Cooper-Munro model of synaptic plasticity. Here we show that the above variety of approaches can all be unified into a single common principle, namely nonlinear Hebbian learning. When nonlinear Hebbian learning is applied to natural images, receptive field shapes were strongly constrained by the input statistics and preprocessing, but exhibited only modest variation across different choices of nonlinearities in neuron models or synaptic plasticity rules. Neither overcompleteness nor sparse network activity are necessary for the development of localized receptive fields. The analysis of alternative sensory modalities such as auditory models or V2 development lead to the same conclusions. In all examples, receptive fields can be predicted a priori by reformulating an abstract model as nonlinear Hebbian learning. Thus nonlinear Hebbian learning and natural statistics can account for many aspects of receptive field formation across models and sensory modalities.

  1. Nonlinear Hebbian Learning as a Unifying Principle in Receptive Field Formation

    PubMed Central

    Gerstner, Wulfram

    2016-01-01

    The development of sensory receptive fields has been modeled in the past by a variety of models including normative models such as sparse coding or independent component analysis and bottom-up models such as spike-timing dependent plasticity or the Bienenstock-Cooper-Munro model of synaptic plasticity. Here we show that the above variety of approaches can all be unified into a single common principle, namely nonlinear Hebbian learning. When nonlinear Hebbian learning is applied to natural images, receptive field shapes were strongly constrained by the input statistics and preprocessing, but exhibited only modest variation across different choices of nonlinearities in neuron models or synaptic plasticity rules. Neither overcompleteness nor sparse network activity are necessary for the development of localized receptive fields. The analysis of alternative sensory modalities such as auditory models or V2 development lead to the same conclusions. In all examples, receptive fields can be predicted a priori by reformulating an abstract model as nonlinear Hebbian learning. Thus nonlinear Hebbian learning and natural statistics can account for many aspects of receptive field formation across models and sensory modalities. PMID:27690349

  2. Integrated Land - Use , Transportation and Environmental Modeling : Validation Case Studies

    DOT National Transportation Integrated Search

    2010-08-01

    For decades the transportation-planning research community has acknowledged the interactions between the evolution of our transportation systems and our land-use, and the need to unify the practices of land-use forecasting and travel-demand modeling ...

  3. Chemical and climatic drivers of radiative forcing due to changes in stratospheric and tropospheric ozone over the 21st century

    NASA Astrophysics Data System (ADS)

    Banerjee, Antara; Maycock, Amanda C.; Pyle, John A.

    2018-02-01

    The ozone radiative forcings (RFs) resulting from projected changes in climate, ozone-depleting substances (ODSs), non-methane ozone precursor emissions and methane between the years 2000 and 2100 are calculated using simulations from the UM-UKCA chemistry-climate model (UK Met Office's Unified Model containing the United Kingdom Chemistry and Aerosols sub-model). Projected measures to improve air-quality through reductions in non-methane tropospheric ozone precursor emissions present a co-benefit for climate, with a net global mean ozone RF of -0.09 W m-2. This is opposed by a positive ozone RF of 0.05 W m-2 due to future decreases in ODSs, which is driven by an increase in tropospheric ozone through stratosphere-to-troposphere transport of air containing higher ozone amounts. An increase in methane abundance by more than a factor of 2 (as projected by the RCP8.5 scenario) is found to drive an ozone RF of 0.18 W m-2, which would greatly outweigh the climate benefits of non-methane tropospheric ozone precursor reductions. A small fraction (˜ 15 %) of the ozone RF due to the projected increase in methane results from increases in stratospheric ozone. The sign of the ozone RF due to future changes in climate (including the radiative effects of greenhouse gases, sea surface temperatures and sea ice changes) is shown to be dependent on the greenhouse gas emissions pathway, with a positive RF (0.05 W m-2) for RCP4.5 and a negative RF (-0.07 W m-2) for the RCP8.5 scenario. This dependence arises mainly from differences in the contribution to RF from stratospheric ozone changes. Considering the increases in tropopause height under climate change causes only small differences (≤ |0.02| W m-2) for the stratospheric, tropospheric and whole-atmosphere RFs.

  4. Wind Sensing, Analysis, and Modeling

    NASA Technical Reports Server (NTRS)

    Corvin, Michael A.

    1995-01-01

    The purpose of this task was to begin development of a unified approach to the sensing, analysis, and modeling of the wind environments in which launch system operate. The initial activity was to examine the current usage and requirements for wind modeling for the Titan 4 vehicle. This was to be followed by joint technical efforts with NASA Langley Research Center to develop applicable analysis methods. This work was to be performed in and demonstrate the use of prototype tools implementing an environment in which to realize a unified system. At the convenience of the customer, due to resource limitations, the task was descoped. The survey of Titan 4 processes was accomplished and is reported in this document. A summary of general requirements is provided. Current versions of prototype Process Management Environment tools are being provided to the customer.

  5. Wind sensing, analysis, and modeling

    NASA Technical Reports Server (NTRS)

    Corvin, Michael A.

    1995-01-01

    The purpose of this task was to begin development of a unified approach to the sensing, analysis, and modeling of the wind environments in which launch systems operate. The initial activity was to examine the current usage and requirements for wind modeling for the Titan 4 vehicle. This was to be followed by joint technical efforts with NASA Langley Research Center to develop applicable analysis methods. This work was to be performed in and demonstrate the use of prototype tools implementing an environment in which to realize a unified system. At the convenience of the customer, due to resource limitations, the task was descoped. The survey of Titan 4 processes was accomplished and is reported in this document. A summary of general requirements is provided . Current versions of prototype Process Management Environment tools are being provided to the customer.

  6. Viewing Knowledge Bases as Qualitative Models.

    ERIC Educational Resources Information Center

    Clancey, William J.

    The concept of a qualitative model provides a unifying perspective for understanding how expert systems differ from conventional programs. Knowledge bases contain qualitative models of systems in the world, that is, primarily non-numeric descriptions that provide a basis for explaining and predicting behavior and formulating action plans. The…

  7. Unifying inflation with ΛCDM epoch in modified f(R) gravity consistent with Solar System tests

    NASA Astrophysics Data System (ADS)

    Nojiri, Shin'ichi; Odintsov, Sergei D.

    2007-12-01

    We suggest two realistic f(R) and one F(G) modified gravities which are consistent with local tests and cosmological bounds. The typical property of such theories is the presence of the effective cosmological constant epochs in such a way that early-time inflation and late-time cosmic acceleration are naturally unified within single model. It is shown that classical instability does not appear here and Newton law is respected. Some discussion of possible anti-gravity regime appearance and related modification of the theory is done.

  8. Stochastic Convection Parameterizations: The Eddy-Diffusivity/Mass-Flux (EDMF) Approach (Invited)

    NASA Astrophysics Data System (ADS)

    Teixeira, J.

    2013-12-01

    In this presentation it is argued that moist convection parameterizations need to be stochastic in order to be realistic - even in deterministic atmospheric prediction systems. A new unified convection and boundary layer parameterization (EDMF) that optimally combines the Eddy-Diffusivity (ED) approach for smaller-scale boundary layer mixing with the Mass-Flux (MF) approach for larger-scale plumes is discussed. It is argued that for realistic simulations stochastic methods have to be employed in this new unified EDMF. Positive results from the implementation of the EDMF approach in atmospheric models are presented.

  9. Environmental assessment and investment strategies of provincial industrial sector in China — Analysis based on DEA model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Juan, E-mail: wangjuan_tju@163.com; Zhao, Tao; Zhang, Xiaohu

    As an energy-intensive industry, the industrial sector consumes 70% of energy consumption and causes serious environmental pollution in China. Also, the government emphasized the promotion of R&D investment in the industrial sector in China's National Plan on Climate Change (2014–2020). It is meaningful and contributes to assessing energy and environmental performance, as well as R&D and industrial pollution control (IPC) investment strategies of China's industrial sector. A non-radial DEA model, as with natural and managerial disposability, was adopted to evaluate this from provincial and regional perspectives during the 2008–2012 period. Energy and environmental performance was evaluated by unified efficiency undermore » natural disposability (UEN), unified efficiency under managerial disposability (UEM), and unified efficiency under natural and managerial disposability (UENM). The empirical results indicated that Shandong and Hainan were efficient under natural and managerial disposability, while other provinces had the potential to improve their energy and environmental performance. The number of provinces that was fit for investments of R&D and IPC increased from 2008 to 2010, then decreased in 2011 and 2012. In spite of this, many provincial industrial sectors should make efforts to reduce pollution by investment on technology. Tianjin, Heilongjiang, Jiangxi and Henan were especially the best investment objects because investments of R&D and IPC turned to be effective for them during the whole study period. Moreover, western China had the highest average UENM, followed by eastern China and central China. Eastern China and central China were rewarding to expand investments. Coal consumption was the main factor to negatively affect unified efficiency whereas the increase in economic development level was primarily responsible for the improvement of unified efficiency. According to the results, differentiated suggestions to further improve energy and environmental performance were proposed.« less

  10. Simulating unstressed crop development and growth using the Unified Plant Growth Model (UPGM)

    USDA-ARS?s Scientific Manuscript database

    Since development of the EPIC model in 1989, many versions of the plant growth component have been incorporated into other erosion and crop management models and subsequently modified to meet model objectives (e.g., WEPS, WEPP, SWAT, ALMANAC, GPFARM). This has resulted in different versions of the ...

  11. On quantum integrable models related to nonlinear quantum optics. An algebraic Bethe ansatz approach

    NASA Astrophysics Data System (ADS)

    Jurčo, Branislav

    1989-08-01

    A unified approach based on Bethe ansatz in a large variety of integrable models in quantum optics is given. Second harmonics generation, three-boson interaction, the Dicke model, and some cases of four-boson interaction as special cases of su(2)⊕su(1,1)-Gaudin models are included.

  12. Performance modeling of automated manufacturing systems

    NASA Astrophysics Data System (ADS)

    Viswanadham, N.; Narahari, Y.

    A unified and systematic treatment is presented of modeling methodologies and analysis techniques for performance evaluation of automated manufacturing systems. The book is the first treatment of the mathematical modeling of manufacturing systems. Automated manufacturing systems are surveyed and three principal analytical modeling paradigms are discussed: Markov chains, queues and queueing networks, and Petri nets.

  13. Toward construction of the unified lepton-nucleus interaction model from a few hundred MeV to GeV region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nakamura, S. X.; Hayato, Y.; Hirai, M.

    2015-05-15

    Next generation neutrino oscillation experiments will need a quantitative understanding of neutrino-nucleus interaction far better than ever. Kinematics covered by the relevant neutrino-nucleus interaction spans wide region, from the quasi-elastic, through the resonance region, to the deeply inelastic scattering region. The neutrino-nucleus interaction in each region has quite different characteristics. Obviously, it is essential to combine different expertise to construct a unified model that covers all the kinematical region of the neutrino-nucleus interaction. Recently, several experimentalists and theorists got together to form a collaboration to tackle this problem. In this contribution, we report the collaboration’s recent activity and a goalmore » in near future.« less

  14. EMDataBank unified data resource for 3DEM.

    PubMed

    Lawson, Catherine L; Patwardhan, Ardan; Baker, Matthew L; Hryc, Corey; Garcia, Eduardo Sanz; Hudson, Brian P; Lagerstedt, Ingvar; Ludtke, Steven J; Pintilie, Grigore; Sala, Raul; Westbrook, John D; Berman, Helen M; Kleywegt, Gerard J; Chiu, Wah

    2016-01-04

    Three-dimensional Electron Microscopy (3DEM) has become a key experimental method in structural biology for a broad spectrum of biological specimens from molecules to cells. The EMDataBank project provides a unified portal for deposition, retrieval and analysis of 3DEM density maps, atomic models and associated metadata (emdatabank.org). We provide here an overview of the rapidly growing 3DEM structural data archives, which include maps in EM Data Bank and map-derived models in the Protein Data Bank. In addition, we describe progress and approaches toward development of validation protocols and methods, working with the scientific community, in order to create a validation pipeline for 3DEM data. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

  15. Unifying error structures in commonly used biotracer mixing models.

    PubMed

    Stock, Brian C; Semmens, Brice X

    2016-10-01

    Mixing models are statistical tools that use biotracers to probabilistically estimate the contribution of multiple sources to a mixture. These biotracers may include contaminants, fatty acids, or stable isotopes, the latter of which are widely used in trophic ecology to estimate the mixed diet of consumers. Bayesian implementations of mixing models using stable isotopes (e.g., MixSIR, SIAR) are regularly used by ecologists for this purpose, but basic questions remain about when each is most appropriate. In this study, we describe the structural differences between common mixing model error formulations in terms of their assumptions about the predation process. We then introduce a new parameterization that unifies these mixing model error structures, as well as implicitly estimates the rate at which consumers sample from source populations (i.e., consumption rate). Using simulations and previously published mixing model datasets, we demonstrate that the new error parameterization outperforms existing models and provides an estimate of consumption. Our results suggest that the error structure introduced here will improve future mixing model estimates of animal diet. © 2016 by the Ecological Society of America.

  16. Information object definition-based unified modeling language representation of DICOM structured reporting: a case study of transcoding DICOM to XML.

    PubMed

    Tirado-Ramos, Alfredo; Hu, Jingkun; Lee, K P

    2002-01-01

    Supplement 23 to DICOM (Digital Imaging and Communications for Medicine), Structured Reporting, is a specification that supports a semantically rich representation of image and waveform content, enabling experts to share image and related patient information. DICOM SR supports the representation of textual and coded data linked to images and waveforms. Nevertheless, the medical information technology community needs models that work as bridges between the DICOM relational model and open object-oriented technologies. The authors assert that representations of the DICOM Structured Reporting standard, using object-oriented modeling languages such as the Unified Modeling Language, can provide a high-level reference view of the semantically rich framework of DICOM and its complex structures. They have produced an object-oriented model to represent the DICOM SR standard and have derived XML-exchangeable representations of this model using World Wide Web Consortium specifications. They expect the model to benefit developers and system architects who are interested in developing applications that are compliant with the DICOM SR specification.

  17. Behavior of predicted convective clouds and precipitation in the high-resolution Unified Model over the Indian summer monsoon region

    NASA Astrophysics Data System (ADS)

    Jayakumar, A.; Sethunadh, Jisesh; Rakhi, R.; Arulalan, T.; Mohandas, Saji; Iyengar, Gopal R.; Rajagopal, E. N.

    2017-05-01

    National Centre for Medium Range Weather Forecasting high-resolution regional convective-scale Unified Model with latest tropical science settings is used to evaluate vertical structure of cloud and precipitation over two prominent monsoon regions: Western Ghats (WG) and Monsoon Core Zone (MCZ). Model radar reflectivity generated using Cloud Feedback Model Intercomparison Project Observation Simulator Package along with CloudSat profiling radar reflectivity is sampled for an active synoptic situation based on a new method using Budyko's index of turbulence (BT). Regime classification based on BT-precipitation relationship is more predominant during the active monsoon period when convective-scale model's resolution increases from 4 km to 1.5 km. Model predicted precipitation and vertical distribution of hydrometeors are found to be generally in agreement with Global Precipitation Measurement products and BT-based CloudSat observation, respectively. Frequency of occurrence of radar reflectivity from model implies that the low-level clouds below freezing level is underestimated compared to the observations over both regions. In addition, high-level clouds in the model predictions are much lesser over WG than MCZ.

  18. A unified view on weakly correlated recurrent networks

    PubMed Central

    Grytskyy, Dmytro; Tetzlaff, Tom; Diesmann, Markus; Helias, Moritz

    2013-01-01

    The diversity of neuron models used in contemporary theoretical neuroscience to investigate specific properties of covariances in the spiking activity raises the question how these models relate to each other. In particular it is hard to distinguish between generic properties of covariances and peculiarities due to the abstracted model. Here we present a unified view on pairwise covariances in recurrent networks in the irregular regime. We consider the binary neuron model, the leaky integrate-and-fire (LIF) model, and the Hawkes process. We show that linear approximation maps each of these models to either of two classes of linear rate models (LRM), including the Ornstein–Uhlenbeck process (OUP) as a special case. The distinction between both classes is the location of additive noise in the rate dynamics, which is located on the output side for spiking models and on the input side for the binary model. Both classes allow closed form solutions for the covariance. For output noise it separates into an echo term and a term due to correlated input. The unified framework enables us to transfer results between models. For example, we generalize the binary model and the Hawkes process to the situation with synaptic conduction delays and simplify derivations for established results. Our approach is applicable to general network structures and suitable for the calculation of population averages. The derived averages are exact for fixed out-degree network architectures and approximate for fixed in-degree. We demonstrate how taking into account fluctuations in the linearization procedure increases the accuracy of the effective theory and we explain the class dependent differences between covariances in the time and the frequency domain. Finally we show that the oscillatory instability emerging in networks of LIF models with delayed inhibitory feedback is a model-invariant feature: the same structure of poles in the complex frequency plane determines the population power spectra. PMID:24151463

  19. Bayesian inference for psychology, part IV: parameter estimation and Bayes factors.

    PubMed

    Rouder, Jeffrey N; Haaf, Julia M; Vandekerckhove, Joachim

    2018-02-01

    In the psychological literature, there are two seemingly different approaches to inference: that from estimation of posterior intervals and that from Bayes factors. We provide an overview of each method and show that a salient difference is the choice of models. The two approaches as commonly practiced can be unified with a certain model specification, now popular in the statistics literature, called spike-and-slab priors. A spike-and-slab prior is a mixture of a null model, the spike, with an effect model, the slab. The estimate of the effect size here is a function of the Bayes factor, showing that estimation and model comparison can be unified. The salient difference is that common Bayes factor approaches provide for privileged consideration of theoretically useful parameter values, such as the value corresponding to the null hypothesis, while estimation approaches do not. Both approaches, either privileging the null or not, are useful depending on the goals of the analyst.

  20. Transcultural Education Model. A Guide for Developing Transitional ESL/LEP and Bilingual Programs Kindergarten through Adult Education.

    ERIC Educational Resources Information Center

    Donaldson, Judy P.

    The Transcultural Education Model presents a unified working model for teaching limited English proficient, English-as-Second-Language (ESL), or English-as-Second-Language transcultural (ESLT) students to read, write, and speak English. The model is designed for students and teachers in elementary, secondary, and adult schools. The model is…

  1. Using a Functional Model to Develop a Mathematical Formula

    ERIC Educational Resources Information Center

    Otto, Charlotte A.; Everett, Susan A.; Luera, Gail R.

    2008-01-01

    The unifying theme of models was incorporated into a required Science Capstone course for pre-service elementary teachers based on national standards in science and mathematics. A model of a teeter-totter was selected for use as an example of a functional model for gathering data as well as a visual model of a mathematical equation for developing…

  2. A Flexible Latent Trait Model for Response Times in Tests

    ERIC Educational Resources Information Center

    Ranger, Jochen; Kuhn, Jorg-Tobias

    2012-01-01

    Latent trait models for response times in tests have become popular recently. One challenge for response time modeling is the fact that the distribution of response times can differ considerably even in similar tests. In order to reduce the need for tailor-made models, a model is proposed that unifies two popular approaches to response time…

  3. An Algebraic Approach to the Eigenstates of the Calogero Model

    NASA Astrophysics Data System (ADS)

    Ujino, Hideaki

    2002-11-01

    An algebraic treatment of the eigenstates of the (AN-1-) Calogero model is presented, which provides an algebraic construction of the nonsymmetric orthogonal eigenvectors, symmetrization, antisymmetrization and calculation of square norms in a unified way.

  4. Acceptance and Commitment Therapy as a Unified Model of Behavior Change

    ERIC Educational Resources Information Center

    Hayes, Steven C.; Pistorello, Jacqueline; Levin, Michael E.

    2012-01-01

    The present article summarizes the assumptions, model, techniques, evidence, and diversity/social justice commitments of Acceptance and Commitment Therapy (ACT). ACT focused on six processes (acceptance, defusion, self, now, values, and action) that bear on a single overall target (psychological flexibility). The ACT model of behavior change has…

  5. ATP3 Unified Field Study Data

    DOE Data Explorer

    Wolfrum, Ed (ORCID:0000000273618931); Knoshug, Eric (ORCID:000000025709914X); Laurens, Lieve (ORCID:0000000349303267); Harmon, Valerie; Dempster, Thomas (ORCID:000000029550488X); McGowan, John (ORCID:0000000266920518); Rosov, Theresa; Cardello, David; Arrowsmith, Sarah; Kempkes, Sarah; Bautista, Maria; Lundquist, Tryg; Crowe, Brandon; Murawsky, Garrett; Nicolai, Eric; Rowe, Egan; Knurek, Emily; Javar, Reyna; Saracco Alvarez, Marcela; Schlosser, Steve; Riddle, Mary; Withstandley, Chris; Chen, Yongsheng; Van Ginkel, Steven; Igou, Thomas; Xu, Chunyan; Hu, Zixuan

    2017-10-20

    ATP3 Unified Field Study Data The Algae Testbed Public-Private Partnership (ATP3) was established with the goal of investigating open pond algae cultivation across different geographic, climatic, seasonal, and operational conditions while setting the benchmark for quality data collection, analysis, and dissemination. Identical algae cultivation systems and data analysis methodologies were established at testbed sites across the continental United States and Hawaii. Within this framework, the Unified Field Studies (UFS) were designed to characterize the cultivation of different algal strains during all 4 seasons across this testbed network. The dataset presented here is the complete, curated, climatic, cultivation, harvest, and biomass composition data for each season at each site. These data enable others to do in-depth cultivation, harvest, techno-economic, life cycle, resource, and predictive growth modeling analysis, as well as develop crop protection strategies for the nascent algae industry. NREL Sub award Number: DE-AC36-08-GO28308

  6. International benchmarking of longitudinal train dynamics simulators: results

    NASA Astrophysics Data System (ADS)

    Wu, Qing; Spiryagin, Maksym; Cole, Colin; Chang, Chongyi; Guo, Gang; Sakalo, Alexey; Wei, Wei; Zhao, Xubao; Burgelman, Nico; Wiersma, Pier; Chollet, Hugues; Sebes, Michel; Shamdani, Amir; Melzi, Stefano; Cheli, Federico; di Gialleonardo, Egidio; Bosso, Nicola; Zampieri, Nicolò; Luo, Shihui; Wu, Honghua; Kaza, Guy-Léon

    2018-03-01

    This paper presents the results of the International Benchmarking of Longitudinal Train Dynamics Simulators which involved participation of nine simulators (TABLDSS, UM, CRE-LTS, TDEAS, PoliTo, TsDyn, CARS, BODYSIM and VOCO) from six countries. Longitudinal train dynamics results and computing time of four simulation cases are presented and compared. The results show that all simulators had basic agreement in simulations of locomotive forces, resistance forces and track gradients. The major differences among different simulators lie in the draft gear models. TABLDSS, UM, CRE-LTS, TDEAS, TsDyn and CARS had general agreement in terms of the in-train forces; minor differences exist as reflections of draft gear model variations. In-train force oscillations were observed in VOCO due to the introduction of wheel-rail contact. In-train force instabilities were sometimes observed in PoliTo and BODYSIM due to the velocity controlled transitional characteristics which could have generated unreasonable transitional stiffness. Regarding computing time per train operational second, the following list is in order of increasing computing speed: VOCO, TsDyn, PoliTO, CARS, BODYSIM, UM, TDEAS, CRE-LTS and TABLDSS (fastest); all simulators except VOCO, TsDyn and PoliTo achieved faster speeds than real-time simulations. Similarly, regarding computing time per integration step, the computing speeds in order are: CRE-LTS, VOCO, CARS, TsDyn, UM, TABLDSS and TDEAS (fastest).

  7. Photoionization and Recombination

    NASA Technical Reports Server (NTRS)

    Nahar, Sultana N.

    2000-01-01

    Theoretically self-consistent calculations for photoionization and (e + ion) recombination are described. The same eigenfunction expansion for the ion is employed in coupled channel calculations for both processes, thus ensuring consistency between cross sections and rates. The theoretical treatment of (e + ion) recombination subsumes both the non-resonant recombination ("radiative recombination"), and the resonant recombination ("di-electronic recombination") processes in a unified scheme. In addition to the total, unified recombination rates, level-specific recombination rates and photoionization cross sections are obtained for a large number of atomic levels. Both relativistic Breit-Pauli, and non-relativistic LS coupling, calculations are carried out in the close coupling approximation using the R-matrix method. Although the calculations are computationally intensive, they yield nearly all photoionization and recombination parameters needed for astrophysical photoionization models with higher precision than hitherto possible, estimated at about 10-20% from comparison with experimentally available data (including experimentally derived DR rates). Results are electronically available for over 40 atoms and ions. Photoionization and recombination of He-, and Li-like C and Fe are described for X-ray modeling. The unified method yields total and complete (e+ion) recombination rate coefficients, that can not otherwise be obtained theoretically or experimentally.

  8. Unifying practice schedules in the timescales of motor learning and performance.

    PubMed

    Verhoeven, F Martijn; Newell, Karl M

    2018-06-01

    In this article, we elaborate from a multiple time scales model of motor learning to examine the independent and integrated effects of massed and distributed practice schedules within- and between-sessions on the persistent (learning) and transient (warm-up, fatigue) processes of performance change. The timescales framework reveals the influence of practice distribution on four learning-related processes: the persistent processes of learning and forgetting, and the transient processes of warm-up decrement and fatigue. The superposition of the different processes of practice leads to a unified set of effects for massed and distributed practice within- and between-sessions in learning motor tasks. This analysis of the interaction between the duration of the interval of practice trials or sessions and parameters of the introduced time scale model captures the unified influence of the between trial and session scheduling of practice on learning and performance. It provides a starting point for new theoretically based hypotheses, and the scheduling of practice that minimizes the negative effects of warm-up decrement, fatigue and forgetting while exploiting the positive effects of learning and retention. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. A unified view of "how allostery works".

    PubMed

    Tsai, Chung-Jung; Nussinov, Ruth

    2014-02-01

    The question of how allostery works was posed almost 50 years ago. Since then it has been the focus of much effort. This is for two reasons: first, the intellectual curiosity of basic science and the desire to understand fundamental phenomena, and second, its vast practical importance. Allostery is at play in all processes in the living cell, and increasingly in drug discovery. Many models have been successfully formulated, and are able to describe allostery even in the absence of a detailed structural mechanism. However, conceptual schemes designed to qualitatively explain allosteric mechanisms usually lack a quantitative mathematical model, and are unable to link its thermodynamic and structural foundations. This hampers insight into oncogenic mutations in cancer progression and biased agonists' actions. Here, we describe how allostery works from three different standpoints: thermodynamics, free energy landscape of population shift, and structure; all with exactly the same allosteric descriptors. This results in a unified view which not only clarifies the elusive allosteric mechanism but also provides structural grasp of agonist-mediated signaling pathways, and guides allosteric drug discovery. Of note, the unified view reasons that allosteric coupling (or communication) does not determine the allosteric efficacy; however, a communication channel is what makes potential binding sites allosteric.

  10. Unified Electromagnetic-Electronic Design of Light Trapping Silicon Solar Cells

    PubMed Central

    Boroumand, Javaneh; Das, Sonali; Vázquez-Guardado, Abraham; Franklin, Daniel; Chanda, Debashis

    2016-01-01

    A three-dimensional unified electromagnetic-electronic model is developed in conjunction with a light trapping scheme in order to predict and maximize combined electron-photon harvesting in ultrathin crystalline silicon solar cells. The comparison between a bare and light trapping cell shows significant enhancement in photon absorption and electron collection. The model further demonstrates that in order to achieve high energy conversion efficiency, charge separation must be optimized through control of the doping profile and surface passivation. Despite having a larger number of surface defect states caused by the surface patterning in light trapping cells, we show that the higher charge carrier generation and collection in this design compensates the absorption and recombination losses and ultimately results in an increase in energy conversion efficiency. The fundamental physics behind this specific design approach is validated through its application to a 3 μm thick functional light trapping solar cell which shows 192% efficiency enhancement with respect to the bare cell of same thickness. Such a unified design approach will pave the path towards achieving the well-known Shockley-Queisser (SQ) limit for c-Si in thin-film (<30 μm) geometries. PMID:27499446

  11. A Unified Framework for Association Analysis with Multiple Related Phenotypes

    PubMed Central

    Stephens, Matthew

    2013-01-01

    We consider the problem of assessing associations between multiple related outcome variables, and a single explanatory variable of interest. This problem arises in many settings, including genetic association studies, where the explanatory variable is genotype at a genetic variant. We outline a framework for conducting this type of analysis, based on Bayesian model comparison and model averaging for multivariate regressions. This framework unifies several common approaches to this problem, and includes both standard univariate and standard multivariate association tests as special cases. The framework also unifies the problems of testing for associations and explaining associations – that is, identifying which outcome variables are associated with genotype. This provides an alternative to the usual, but conceptually unsatisfying, approach of resorting to univariate tests when explaining and interpreting significant multivariate findings. The method is computationally tractable genome-wide for modest numbers of phenotypes (e.g. 5–10), and can be applied to summary data, without access to raw genotype and phenotype data. We illustrate the methods on both simulated examples, and to a genome-wide association study of blood lipid traits where we identify 18 potential novel genetic associations that were not identified by univariate analyses of the same data. PMID:23861737

  12. Dirac relaxation of the Israel junction conditions: Unified Randall-Sundrum brane theory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Davidson, Aharon; Gurwich, Ilya

    2006-08-15

    Following Dirac's brane variation prescription, the brane must not be deformed during the variation process, or else the linearity of the variation may be lost. Alternatively, the variation of the brane is done, in a special Dirac frame, by varying the bulk coordinate system itself. Imposing appropriate Dirac-style boundary conditions on the constrained 'sandwiched' gravitational action, we show how Israel junction conditions get relaxed, but remarkably, all solutions of the original Israel equations are still respected. The Israel junction conditions are traded, in the Z{sub 2}-symmetric case, for a generalized Regge-Teitelboim type equation (plus a local conservation law), and inmore » the generic Z{sub 2}-asymmetric case, for a pair of coupled Regge-Teitelboim equations. The Randall-Sundrum model and its derivatives, such as the Dvali-Gabadadze-Porrati and the Collins-Holdom models, get generalized accordingly. Furthermore, Randall-Sundrum and Regge-Teitelboim brane theories appear now to be two different faces of the one and the same unified brane theory. Within the framework of unified brane cosmology, we examine the dark matter/energy interpretation of the effective energy/momentum deviations from general relativity.« less

  13. Neutral theory and the species abundance distribution: recent developments and prospects for unifying niche and neutral perspectives

    PubMed Central

    Matthews, Thomas J; Whittaker, Robert J

    2014-01-01

    Published in 2001, The Unified Neutral Theory of Biodiversity and Biogeography (UNTB) emphasizes the importance of stochastic processes in ecological community structure, and has challenged the traditional niche-based view of ecology. While neutral models have since been applied to a broad range of ecological and macroecological phenomena, the majority of research relating to neutral theory has focused exclusively on the species abundance distribution (SAD). Here, we synthesize the large body of work on neutral theory in the context of the species abundance distribution, with a particular focus on integrating ideas from neutral theory with traditional niche theory. First, we summarize the basic tenets of neutral theory; both in general and in the context of SADs. Second, we explore the issues associated with neutral theory and the SAD, such as complications with fitting and model comparison, the underlying assumptions of neutral models, and the difficultly of linking pattern to process. Third, we highlight the advances in understanding of SADs that have resulted from neutral theory and models. Finally, we focus consideration on recent developments aimed at unifying neutral- and niche-based approaches to ecology, with a particular emphasis on what this means for SAD theory, embracing, for instance, ideas of emergent neutrality and stochastic niche theory. We put forward the argument that the prospect of the unification of niche and neutral perspectives represents one of the most promising future avenues of neutral theory research. PMID:25360266

  14. A CPT for Improving Turbulence and Cloud Processes in the NCEP Global Models

    NASA Astrophysics Data System (ADS)

    Krueger, S. K.; Moorthi, S.; Randall, D. A.; Pincus, R.; Bogenschutz, P.; Belochitski, A.; Chikira, M.; Dazlich, D. A.; Swales, D. J.; Thakur, P. K.; Yang, F.; Cheng, A.

    2016-12-01

    Our Climate Process Team (CPT) is based on the premise that the NCEP (National Centers for Environmental Prediction) global models can be improved by installing an integrated, self-consistent description of turbulence, clouds, deep convection, and the interactions between clouds and radiative and microphysical processes. The goal of our CPT is to unify the representation of turbulence and subgrid-scale (SGS) cloud processes and to unify the representation of SGS deep convective precipitation and grid-scale precipitation as the horizontal resolution decreases. We aim to improve the representation of small-scale phenomena by implementing a PDF-based SGS turbulence and cloudiness scheme that replaces the boundary layer turbulence scheme, the shallow convection scheme, and the cloud fraction schemes in the GFS (Global Forecast System) and CFS (Climate Forecast System) global models. We intend to improve the treatment of deep convection by introducing a unified parameterization that scales continuously between the simulation of individual clouds when and where the grid spacing is sufficiently fine and the behavior of a conventional parameterization of deep convection when and where the grid spacing is coarse. We will endeavor to improve the representation of the interactions of clouds, radiation, and microphysics in the GFS/CFS by using the additional information provided by the PDF-based SGS cloud scheme. The team is evaluating the impacts of the model upgrades with metrics used by the NCEP short-range and seasonal forecast operations.

  15. Neutral theory and the species abundance distribution: recent developments and prospects for unifying niche and neutral perspectives.

    PubMed

    Matthews, Thomas J; Whittaker, Robert J

    2014-06-01

    Published in 2001, The Unified Neutral Theory of Biodiversity and Biogeography (UNTB) emphasizes the importance of stochastic processes in ecological community structure, and has challenged the traditional niche-based view of ecology. While neutral models have since been applied to a broad range of ecological and macroecological phenomena, the majority of research relating to neutral theory has focused exclusively on the species abundance distribution (SAD). Here, we synthesize the large body of work on neutral theory in the context of the species abundance distribution, with a particular focus on integrating ideas from neutral theory with traditional niche theory. First, we summarize the basic tenets of neutral theory; both in general and in the context of SADs. Second, we explore the issues associated with neutral theory and the SAD, such as complications with fitting and model comparison, the underlying assumptions of neutral models, and the difficultly of linking pattern to process. Third, we highlight the advances in understanding of SADs that have resulted from neutral theory and models. Finally, we focus consideration on recent developments aimed at unifying neutral- and niche-based approaches to ecology, with a particular emphasis on what this means for SAD theory, embracing, for instance, ideas of emergent neutrality and stochastic niche theory. We put forward the argument that the prospect of the unification of niche and neutral perspectives represents one of the most promising future avenues of neutral theory research.

  16. The New Unified Theory of ATP Synthesis/Hydrolysis and Muscle Contraction, Its Manifold Fundamental Consequences and Mechanistic Implications and Its Applications in Health and Disease

    PubMed Central

    Nath, Sunil

    2008-01-01

    Complete details of the thermodynamics and molecular mechanisms of ATP synthesis/hydrolysis and muscle contraction are offered from the standpoint of the torsional mechanism of energy transduction and ATP synthesis and the rotation-uncoiling-tilt (RUT) energy storage mechanism of muscle contraction. The manifold fundamental consequences and mechanistic implications of the unified theory for oxidative phosphorylation and muscle contraction are explained. The consistency of current mechanisms of ATP synthesis and muscle contraction with experiment is assessed, and the novel insights of the unified theory are shown to take us beyond the binding change mechanism, the chemiosmotic theory and the lever arm model. It is shown from first principles how previous theories of ATP synthesis and muscle contraction violate both the first and second laws of thermodynamics, necessitating their revision. It is concluded that the new paradigm, ten years after making its first appearance, is now perfectly poised to replace the older theories. Finally, applications of the unified theory in cell life and cell death are outlined and prospects for future research are explored. While it is impossible to cover each and every specific aspect of the above, an attempt has been made here to address all the pertinent details and what is presented should be sufficient to convince the reader of the novelty, originality, breakthrough nature and power of the unified theory, its manifold fundamental consequences and mechanistic implications, and its applications in health and disease. PMID:19325832

  17. Real-time monitoring and short-term forecasting of drought in Norway

    NASA Astrophysics Data System (ADS)

    Kwok Wong, Wai; Hisdal, Hege

    2013-04-01

    Drought is considered to be one of the most costly natural disasters. Drought monitoring and forecasting are thus important for sound water management. In this study hydrological drought characteristics applicable for real-time monitoring and short-term forecasting of drought in Norway were developed. A spatially distributed hydrological model (HBV) implemented in a Web-based GIS framework provides a platform for drought analyses and visualizations. A number of national drought maps can be produced, which is a simple and effective way to communicate drought conditions to decision makers and the public. The HBV model is driven by precipitation and air temperature data. On a daily time step it calculates the water balance for 1 x 1 km2 grid cells characterized by their elevation and land use. Drought duration and areal drought coverage for runoff and subsurface storage (sum of soil moisture and groundwater) were derived. The threshold level method was used to specify drought conditions on a grid cell basis. The daily 10th percentile thresholds were derived from seven-day windows centered on that calendar day from the reference period 1981-2010 (threshold not exceeded 10% of the time). Each individual grid cell was examined to determine if it was below its respective threshold level. Daily drought-stricken areas can then be easily identified when visualized on a map. The drought duration can also be tracked and calculated by a retrospective analysis. Real-time observations from synoptic stations interpolated to a regular grid of 1 km resolution constituted the forcing data for the current situation. 9-day meteorological forecasts were used as input to the HBV model to obtain short-term hydrological drought forecasts. Downscaled precipitation and temperature fields from two different atmospheric models were applied. The first two days of the forecast period adopted the forecasts from Unified Model (UM4) while the following seven days were based on the 9-day forecasts from ECMWF. The approach has been tested and is now available on the Web for operational water management.

  18. Kinome-wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics.

    PubMed

    Bailey, Fiona P; Clarke, Kim; Kalirai, Helen; Kenyani, Jenna; Shahidipour, Haleh; Falciani, Francesco; Coulson, Judy M; Sacco, Joseph J; Coupland, Sarah E; Eyers, Patrick A

    2018-03-01

    Metastatic uveal melanoma (UM) is invariably fatal, usually within a year of diagnosis. There are currently no effective therapies, and clinical studies employing kinase inhibitors have so far demonstrated limited success. This is despite common activating mutations in GNAQ/11 genes, which trigger signalling pathways that might predispose tumours to a variety of targeted drugs. In this study, we have profiled kinome expression network dynamics in various human ocular melanomas. We uncovered a shared transcriptional profile in human primary UM samples and across a variety of experimental cell-based models. The poor overall response of UM cells to FDA-approved kinase inhibitors contrasted with much higher sensitivity to the bromodomain inhibitor JQ1, a broad transcriptional repressor. Mechanistically, we identified a repressed FOXM1-dependent kinase subnetwork in JQ1-exposed cells that contained multiple cell cycle-regulated protein kinases. Consistently, we demonstrated vulnerability of UM cells to inhibitors of mitotic protein kinases within this network, including the investigational PLK1 inhibitor BI6727. We conclude that analysis of kinome-wide signalling network dynamics has the potential to reveal actionable drug targets and inhibitors of potential therapeutic benefit for UM patients. © 2017 The Authors. Pigment Cell & Melanoma Research Published by John Wiley & Sons.

  19. Sediment transport modeling in deposited bed sewers: unified form of May's equations using the particle swarm optimization algorithm.

    PubMed

    Safari, Mir Jafar Sadegh; Shirzad, Akbar; Mohammadi, Mirali

    2017-08-01

    May proposed two dimensionless parameters of transport (η) and mobility (F s ) for self-cleansing design of sewers with deposited bed condition. The relationships between those two parameters were introduced in conditional form for specific ranges of F s , which makes it difficult to use as a practical tool for sewer design. In this study, using the same experimental data used by May and employing the particle swarm optimization algorithm, a unified equation is recommended based on η and F s . The developed model is compared with original May relationships as well as corresponding models available in the literature. A large amount of data taken from the literature is used for the models' evaluation. The results demonstrate that the developed model in this study is superior to May and other existing models in the literature. Due to the fact that in May's dimensionless parameters more effective variables in the sediment transport process in sewers with deposited bed condition are considered, it is concluded that the revised May equation proposed in this study is a reliable model for sewer design.

  20. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2010-01-01

    A multi-scale modeling system with unified physics has been developed at NASA Goddard Space Flight Center (GSFC). The system consists of an MMF, the coupled NASA Goddard finite-volume GCM (fvGCM) and Goddard Cumulus Ensemble model (GCE, a CRM); the state-of-the-art Weather Research and Forecasting model (WRF) and the stand alone GCE. These models can share the same microphysical schemes, radiation (including explicitly calculated cloud optical properties), and surface models that have been developed, improved and tested for different environments. In this talk, I will present: (1) A brief review on GCE model and its applications on the impact of the aerosol on deep precipitation processes, (2) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) A discussion on the Goddard WRF version (its developments and applications). We are also performing the inline tracer calculation to comprehend the ph ysical processes (i.e., boundary layer and each quadrant in the boundary layer) related to the development and structure of hurricanes and mesoscale convective systems.

  1. A Unified Model of Performance for Predicting the Effects of Sleep and Caffeine.

    PubMed

    Ramakrishnan, Sridhar; Wesensten, Nancy J; Kamimori, Gary H; Moon, James E; Balkin, Thomas J; Reifman, Jaques

    2016-10-01

    Existing mathematical models of neurobehavioral performance cannot predict the beneficial effects of caffeine across the spectrum of sleep loss conditions, limiting their practical utility. Here, we closed this research gap by integrating a model of caffeine effects with the recently validated unified model of performance (UMP) into a single, unified modeling framework. We then assessed the accuracy of this new UMP in predicting performance across multiple studies. We hypothesized that the pharmacodynamics of caffeine vary similarly during both wakefulness and sleep, and that caffeine has a multiplicative effect on performance. Accordingly, to represent the effects of caffeine in the UMP, we multiplied a dose-dependent caffeine factor (which accounts for the pharmacokinetics and pharmacodynamics of caffeine) to the performance estimated in the absence of caffeine. We assessed the UMP predictions in 14 distinct laboratory- and field-study conditions, including 7 different sleep-loss schedules (from 5 h of sleep per night to continuous sleep loss for 85 h) and 6 different caffeine doses (from placebo to repeated 200 mg doses to a single dose of 600 mg). The UMP accurately predicted group-average psychomotor vigilance task performance data across the different sleep loss and caffeine conditions (6% < error < 27%), yielding greater accuracy for mild and moderate sleep loss conditions than for more severe cases. Overall, accounting for the effects of caffeine resulted in improved predictions (after caffeine consumption) by up to 70%. The UMP provides the first comprehensive tool for accurate selection of combinations of sleep schedules and caffeine countermeasure strategies to optimize neurobehavioral performance. © 2016 Associated Professional Sleep Societies, LLC.

  2. A Unified Model of Performance: Validation of its Predictions across Different Sleep/Wake Schedules.

    PubMed

    Ramakrishnan, Sridhar; Wesensten, Nancy J; Balkin, Thomas J; Reifman, Jaques

    2016-01-01

    Historically, mathematical models of human neurobehavioral performance developed on data from one sleep study were limited to predicting performance in similar studies, restricting their practical utility. We recently developed a unified model of performance (UMP) to predict the effects of the continuum of sleep loss-from chronic sleep restriction (CSR) to total sleep deprivation (TSD) challenges-and validated it using data from two studies of one laboratory. Here, we significantly extended this effort by validating the UMP predictions across a wide range of sleep/wake schedules from different studies and laboratories. We developed the UMP on psychomotor vigilance task (PVT) lapse data from one study encompassing four different CSR conditions (7 d of 3, 5, 7, and 9 h of sleep/night), and predicted performance in five other studies (from four laboratories), including different combinations of TSD (40 to 88 h), CSR (2 to 6 h of sleep/night), control (8 to 10 h of sleep/night), and nap (nocturnal and diurnal) schedules. The UMP accurately predicted PVT performance trends across 14 different sleep/wake conditions, yielding average prediction errors between 7% and 36%, with the predictions lying within 2 standard errors of the measured data 87% of the time. In addition, the UMP accurately predicted performance impairment (average error of 15%) for schedules (TSD and naps) not used in model development. The unified model of performance can be used as a tool to help design sleep/wake schedules to optimize the extent and duration of neurobehavioral performance and to accelerate recovery after sleep loss. © 2016 Associated Professional Sleep Societies, LLC.

  3. Neuro-cognitive mechanisms of conscious and unconscious visual perception: From a plethora of phenomena to general principles

    PubMed Central

    Kiefer, Markus; Ansorge, Ulrich; Haynes, John-Dylan; Hamker, Fred; Mattler, Uwe; Verleger, Rolf; Niedeggen, Michael

    2011-01-01

    Psychological and neuroscience approaches have promoted much progress in elucidating the cognitive and neural mechanisms that underlie phenomenal visual awareness during the last decades. In this article, we provide an overview of the latest research investigating important phenomena in conscious and unconscious vision. We identify general principles to characterize conscious and unconscious visual perception, which may serve as important building blocks for a unified model to explain the plethora of findings. We argue that in particular the integration of principles from both conscious and unconscious vision is advantageous and provides critical constraints for developing adequate theoretical models. Based on the principles identified in our review, we outline essential components of a unified model of conscious and unconscious visual perception. We propose that awareness refers to consolidated visual representations, which are accessible to the entire brain and therefore globally available. However, visual awareness not only depends on consolidation within the visual system, but is additionally the result of a post-sensory gating process, which is mediated by higher-level cognitive control mechanisms. We further propose that amplification of visual representations by attentional sensitization is not exclusive to the domain of conscious perception, but also applies to visual stimuli, which remain unconscious. Conscious and unconscious processing modes are highly interdependent with influences in both directions. We therefore argue that exactly this interdependence renders a unified model of conscious and unconscious visual perception valuable. Computational modeling jointly with focused experimental research could lead to a better understanding of the plethora of empirical phenomena in consciousness research. PMID:22253669

  4. 24 CFR 578.11 - Unified Funding Agency.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Unified Funding Agency. 578.11... of Care § 578.11 Unified Funding Agency. (a) Becoming a Unified Funding Agency. To become designated as the Unified Funding Agency (UFA) for a Continuum, a collaborative applicant must be selected by...

  5. A unified RANS–LES model: Computational development, accuracy and cost

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gopalan, Harish, E-mail: hgopalan@uwyo.edu; Heinz, Stefan, E-mail: heinz@uwyo.edu; Stöllinger, Michael K., E-mail: MStoell@uwyo.edu

    2013-09-15

    Large eddy simulation (LES) is computationally extremely expensive for the investigation of wall-bounded turbulent flows at high Reynolds numbers. A way to reduce the computational cost of LES by orders of magnitude is to combine LES equations with Reynolds-averaged Navier–Stokes (RANS) equations used in the near-wall region. A large variety of such hybrid RANS–LES methods are currently in use such that there is the question of which hybrid RANS-LES method represents the optimal approach. The properties of an optimal hybrid RANS–LES model are formulated here by taking reference to fundamental properties of fluid flow equations. It is shown that unifiedmore » RANS–LES models derived from an underlying stochastic turbulence model have the properties of optimal hybrid RANS–LES models. The rest of the paper is organized in two parts. First, a priori and a posteriori analyses of channel flow data are used to find the optimal computational formulation of the theoretically derived unified RANS–LES model and to show that this computational model, which is referred to as linear unified model (LUM), does also have all the properties of an optimal hybrid RANS–LES model. Second, a posteriori analyses of channel flow data are used to study the accuracy and cost features of the LUM. The following conclusions are obtained. (i) Compared to RANS, which require evidence for their predictions, the LUM has the significant advantage that the quality of predictions is relatively independent of the RANS model applied. (ii) Compared to LES, the significant advantage of the LUM is a cost reduction of high-Reynolds number simulations by a factor of 0.07Re{sup 0.46}. For coarse grids, the LUM has a significant accuracy advantage over corresponding LES. (iii) Compared to other usually applied hybrid RANS–LES models, it is shown that the LUM provides significantly improved predictions.« less

  6. Analysis of Predicted Aircraft Wake Vortex Transport and Comparison with Experiment Volume II -- Appendixes

    DOT National Transportation Integrated Search

    1974-04-01

    A unifying wake vortex transport model is developed and applied to a wake vortex predictive system concept. The fundamentals of vortex motion underlying the predictive model are discussed including vortex decay, bursting and instability phenomena. A ...

  7. Fish Consumption Advisories: Toward a Unified, Scientifically Credible Approach

    EPA Science Inventory

    A model is proposed for fish consumption advisories based on consensus-derived risk assessment values for common contaminants in fish and the latest risk assessment methods. he model accounts in part for the expected toxicity to mixtures of chemicals, the underlying uncertainties...

  8. A unifying framework for systems modeling, control systems design, and system operation

    NASA Technical Reports Server (NTRS)

    Dvorak, Daniel L.; Indictor, Mark B.; Ingham, Michel D.; Rasmussen, Robert D.; Stringfellow, Margaret V.

    2005-01-01

    Current engineering practice in the analysis and design of large-scale multi-disciplinary control systems is typified by some form of decomposition- whether functional or physical or discipline-based-that enables multiple teams to work in parallel and in relative isolation. Too often, the resulting system after integration is an awkward marriage of different control and data mechanisms with poor end-to-end accountability. System of systems engineering, which faces this problem on a large scale, cries out for a unifying framework to guide analysis, design, and operation. This paper describes such a framework based on a state-, model-, and goal-based architecture for semi-autonomous control systems that guides analysis and modeling, shapes control system software design, and directly specifies operational intent. This paper illustrates the key concepts in the context of a large-scale, concurrent, globally distributed system of systems: NASA's proposed Array-based Deep Space Network.

  9. Representing nursing guideline with unified modeling language to facilitate development of a computer system: a case study.

    PubMed

    Choi, Jeeyae; Choi, Jeungok E

    2014-01-01

    To provide best recommendations at the point of care, guidelines have been implemented in computer systems. As a prerequisite, guidelines are translated into a computer-interpretable guideline format. Since there are no specific tools to translate nursing guidelines, only a few nursing guidelines are translated and implemented in computer systems. Unified modeling language (UML) is a software writing language and is known to well and accurately represent end-users' perspective, due to the expressive characteristics of the UML. In order to facilitate the development of computer systems for nurses' use, the UML was used to translate a paper-based nursing guideline, and its ease of use and the usefulness were tested through a case study of a genetic counseling guideline. The UML was found to be a useful tool to nurse informaticians and a sufficient tool to model a guideline in a computer program.

  10. Tachyon cosmology with non-vanishing minimum potential: a unified model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Huiquan, E-mail: hqli@ustc.edu.cn

    2012-07-01

    We investigate the tachyon condensation process in the effective theory with non-vanishing minimum potential and its implications to cosmology. It is shown that the tachyon condensation on an unstable three-brane described by this modified tachyon field theory leads to lower-dimensional branes (defects) forming within a stable three-brane. Thus, in the cosmological background, we can get well-behaved tachyon matter after tachyon inflation, (partially) avoiding difficulties encountered in the original tachyon cosmological models. This feature also implies that the tachyon inflated and reheated universe is followed by a Chaplygin gas dark matter and dark energy universe. Hence, such an unstable three-brane behavesmore » quite like our universe, reproducing the key features of the whole evolutionary history of the universe and providing a unified description of inflaton, dark matter and dark energy in a very simple single-scalar field model.« less

  11. A New Unified Analysis of Estimate Errors by Model-Matching Phase-Estimation Methods for Sensorless Drive of Permanent-Magnet Synchronous Motors and New Trajectory-Oriented Vector Control, Part II

    NASA Astrophysics Data System (ADS)

    Shinnaka, Shinji

    This paper presents a new unified analysis of estimate errors by model-matching extended-back-EMF estimation methods for sensorless drive of permanent-magnet synchronous motors. Analytical solutions about estimate errors, whose validity is confirmed by numerical experiments, are rich in universality and applicability. As an example of universality and applicability, a new trajectory-oriented vector control method is proposed, which can realize directly quasi-optimal strategy minimizing total losses with no additional computational loads by simply orienting one of vector-control coordinates to the associated quasi-optimal trajectory. The coordinate orientation rule, which is analytically derived, is surprisingly simple. Consequently the trajectory-oriented vector control method can be applied to a number of conventional vector control systems using model-matching extended-back-EMF estimation methods.

  12. Depth Reconstruction from Single Images Using a Convolutional Neural Network and a Condition Random Field Model.

    PubMed

    Liu, Dan; Liu, Xuejun; Wu, Yiguang

    2018-04-24

    This paper presents an effective approach for depth reconstruction from a single image through the incorporation of semantic information and local details from the image. A unified framework for depth acquisition is constructed by joining a deep Convolutional Neural Network (CNN) and a continuous pairwise Conditional Random Field (CRF) model. Semantic information and relative depth trends of local regions inside the image are integrated into the framework. A deep CNN network is firstly used to automatically learn a hierarchical feature representation of the image. To get more local details in the image, the relative depth trends of local regions are incorporated into the network. Combined with semantic information of the image, a continuous pairwise CRF is then established and is used as the loss function of the unified model. Experiments on real scenes demonstrate that the proposed approach is effective and that the approach obtains satisfactory results.

  13. Unified TeV scale picture of baryogenesis and dark matter.

    PubMed

    Babu, K S; Mohapatra, R N; Nasri, Salah

    2007-04-20

    We present a simple extension of the minimal supersymmetric standard model which provides a unified picture of cosmological baryon asymmetry and dark matter. Our model introduces a gauge singlet field N and a color triplet field X which couple to the right-handed quark fields. The out-of-equilibrium decay of the Majorana fermion N mediated by the exchange of the scalar field X generates adequate baryon asymmetry for MN approximately 100 GeV and MX approximately TeV. The scalar partner of N (denoted N1) is naturally the lightest SUSY particle as it has no gauge interactions and plays the role of dark matter. The model is experimentally testable in (i) neutron-antineutron oscillations with a transition time estimated to be around 10(10)sec, (ii) discovery of colored particles X at LHC with mass of order TeV, and (iii) direct dark matter detection with a predicted cross section in the observable range.

  14. A general theory of linear cosmological perturbations: stability conditions, the quasistatic limit and dynamics

    NASA Astrophysics Data System (ADS)

    Lagos, Macarena; Bellini, Emilio; Noller, Johannes; Ferreira, Pedro G.; Baker, Tessa

    2018-03-01

    We analyse cosmological perturbations around a homogeneous and isotropic background for scalar-tensor, vector-tensor and bimetric theories of gravity. Building on previous results, we propose a unified view of the effective parameters of all these theories. Based on this structure, we explore the viable space of parameters for each family of models by imposing the absence of ghosts and gradient instabilities. We then focus on the quasistatic regime and confirm that all these theories can be approximated by the phenomenological two-parameter model described by an effective Newton's constant and the gravitational slip. Within the quasistatic regime we pinpoint signatures which can distinguish between the broad classes of models (scalar-tensor, vector-tensor or bimetric). Finally, we present the equations of motion for our unified approach in such a way that they can be implemented in Einstein-Boltzmann solvers.

  15. Can a Unified Service Delivery Philosophy Be Identified in Aging and Disability Organizations? Exploring Competing Service Delivery Models Through the Voices of the Workforce in These Organizations.

    PubMed

    Keefe, Bronwyn

    2018-01-01

    Services for older adults and younger people with disabilities are increasingly merging, as reflected in the creation of Aging and Disability Resource Centers (ADRCs). Using ADRCs to coordinate services is challenging, primarily because these fields have different service delivery philosophies. Independent Living Centers, which serve people with disabilities, have a philosophy that emphasizes consumer control and peer mentoring. However, the aging service delivery philosophy is based in a case management or medical model in which the role of consumers directing their services is less pronounced. Using institutional logics theory and a qualitative research design, this study explored whether a unified service delivery philosophy for ADRCs was emerging. Based on focus groups and questionnaires with staff from ADRCs, findings revealed that competing service delivery models continue to operate in the aging and disability fields.

  16. A unified wall function for compressible turbulence modelling

    NASA Astrophysics Data System (ADS)

    Ong, K. C.; Chan, A.

    2018-05-01

    Turbulence modelling near the wall often requires a high mesh density clustered around the wall and the first cells adjacent to the wall to be placed in the viscous sublayer. As a result, the numerical stability is constrained by the smallest cell size and hence requires high computational overhead. In the present study, a unified wall function is developed which is valid for viscous sublayer, buffer sublayer and inertial sublayer, as well as including effects of compressibility, heat transfer and pressure gradient. The resulting wall function applies to compressible turbulence modelling for both isothermal and adiabatic wall boundary conditions with the non-zero pressure gradient. Two simple wall function algorithms are implemented for practical computation of isothermal and adiabatic wall boundary conditions. The numerical results show that the wall function evaluates the wall shear stress and turbulent quantities of wall adjacent cells at wide range of non-dimensional wall distance and alleviate the number and size of cells required.

  17. A Model of E-Learning Uptake and Continued Use in Higher Education Institutions

    ERIC Educational Resources Information Center

    Pinpathomrat, Nakarin; Gilbert, Lester; Wills, Gary B.

    2013-01-01

    This research investigates the factors that affect a students' take-up and continued use of E-learning. A mathematical model was constructed by applying three grounded theories; Unified Theory of Acceptance and Use of Technology, Keller's ARCS model, and Expectancy Disconfirm Theory. The learning preference factor was included in the model.…

  18. A Unified Approach to Quantifying Feedbacks in Earth System Models

    NASA Astrophysics Data System (ADS)

    Taylor, K. E.

    2008-12-01

    In order to speed progress in reducing uncertainty in climate projections, the processes that most strongly influence those projections must be identified. It is of some importance, therefore, to assess the relative strengths of various climate feedbacks and to determine the degree to which various earth system models (ESMs) agree in their simulations of these processes. Climate feedbacks have been traditionally quantified in terms of their impact on the radiative balance of the planet, whereas carbon cycle responses have been assessed in terms of the size of the perturbations to the surface fluxes of carbon dioxide. In this study we introduce a diagnostic strategy for unifying the two approaches, which allows us to directly compare the strength of carbon-climate feedbacks with other conventional climate feedbacks associated with atmospheric and surface changes. Applying this strategy to a highly simplified model of the carbon-climate system demonstrates the viability of the approach. In the simple model we find that even if the strength of the carbon-climate feedbacks is very large, the uncertainty associated with the overall response of the climate system is likely to be dominated by uncertainties in the much larger feedbacks associated with clouds. This does not imply that the carbon cycle itself is unimportant, only that changes in the carbon cycle that are associated with climate change have a relatively small impact on global temperatures. This new, unified diagnostic approach is suitable for assessing feedbacks in even the most sophisticated earth system models. It will be interesting to see whether our preliminary conclusions are confirmed when output from the more realistic models is analyzed. This work was carried out at the University of California Lawrence Livermore National Laboratory under Contract W-7405-Eng-48.

  19. A general modeling framework for describing spatially structured population dynamics

    USGS Publications Warehouse

    Sample, Christine; Fryxell, John; Bieri, Joanna; Federico, Paula; Earl, Julia; Wiederholt, Ruscena; Mattsson, Brady; Flockhart, Tyler; Nicol, Sam; Diffendorfer, James E.; Thogmartin, Wayne E.; Erickson, Richard A.; Norris, D. Ryan

    2017-01-01

    Variation in movement across time and space fundamentally shapes the abundance and distribution of populations. Although a variety of approaches model structured population dynamics, they are limited to specific types of spatially structured populations and lack a unifying framework. Here, we propose a unified network-based framework sufficiently novel in its flexibility to capture a wide variety of spatiotemporal processes including metapopulations and a range of migratory patterns. It can accommodate different kinds of age structures, forms of population growth, dispersal, nomadism and migration, and alternative life-history strategies. Our objective was to link three general elements common to all spatially structured populations (space, time and movement) under a single mathematical framework. To do this, we adopt a network modeling approach. The spatial structure of a population is represented by a weighted and directed network. Each node and each edge has a set of attributes which vary through time. The dynamics of our network-based population is modeled with discrete time steps. Using both theoretical and real-world examples, we show how common elements recur across species with disparate movement strategies and how they can be combined under a unified mathematical framework. We illustrate how metapopulations, various migratory patterns, and nomadism can be represented with this modeling approach. We also apply our network-based framework to four organisms spanning a wide range of life histories, movement patterns, and carrying capacities. General computer code to implement our framework is provided, which can be applied to almost any spatially structured population. This framework contributes to our theoretical understanding of population dynamics and has practical management applications, including understanding the impact of perturbations on population size, distribution, and movement patterns. By working within a common framework, there is less chance that comparative analyses are colored by model details rather than general principles

  20. Condition Based Maintenance Technology Impact Study: Assessment Methods, Study Design and Interim Results

    DTIC Science & Technology

    2014-07-01

    Unified Theory of Acceptance and Use of Technology, Structuration Model of Technology, UNCLASSIFIED DSTO-TR-2992 UNCLASSIFIED 5 Adaptive...Structuration Theory , Model of Mutual Adaptation, Model of Technology Appropriation, Diffusion/Implementation Model, and Tri-core Model, among others [11...simulation gaming essay/scenario writing genius forecasting role play/acting backcasting swot brainstorming relevance tree/logic chart scenario workshop

  1. Middle Rio Grande Cooperative Water Model

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tidwell, Vince; Passell, Howard

    2005-11-01

    This is computer simulation model built in a commercial modeling product Called Studio Expert, developed by Powersim, Inc. The simulation model is built in a system dynamics environment, allowing the simulation of the interaction among multiple systems that are all changing over time. The model focuses on hydrology, ecology, demography, and economy of the Middle Rio Grande, with Water as the unifying feature.

  2. MODeLeR: A Virtual Constructivist Learning Environment and Methodology for Object-Oriented Design

    ERIC Educational Resources Information Center

    Coffey, John W.; Koonce, Robert

    2008-01-01

    This article contains a description of the organization and method of use of an active learning environment named MODeLeR, (Multimedia Object Design Learning Resource), a tool designed to facilitate the learning of concepts pertaining to object modeling with the Unified Modeling Language (UML). MODeLeR was created to provide an authentic,…

  3. Unified Dark Matter scalar field models with fast transition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bertacca, Daniele; Bruni, Marco; Piattella, Oliver F.

    2011-02-01

    We investigate the general properties of Unified Dark Matter (UDM) scalar field models with Lagrangians with a non-canonical kinetic term, looking specifically for models that can produce a fast transition between an early Einstein-de Sitter CDM-like era and a later Dark Energy like phase, similarly to the barotropic fluid UDM models in JCAP01(2010)014. However, while the background evolution can be very similar in the two cases, the perturbations are naturally adiabatic in fluid models, while in the scalar field case they are necessarily non-adiabatic. The new approach to building UDM Lagrangians proposed here allows to escape the common problem ofmore » the fine-tuning of the parameters which plague many UDM models. We analyse the properties of perturbations in our model, focusing on the the evolution of the effective speed of sound and that of the Jeans length. With this insight, we can set theoretical constraints on the parameters of the model, predicting sufficient conditions for the model to be viable. An interesting feature of our models is that what can be interpreted as w{sub DE} can be < −1 without violating the null energy conditions.« less

  4. GFDL's unified regional-global weather-climate modeling system with variable resolution capability for severe weather predictions and regional climate simulations

    NASA Astrophysics Data System (ADS)

    Lin, S. J.

    2015-12-01

    The NOAA/Geophysical Fluid Dynamics Laboratory has been developing a unified regional-global modeling system with variable resolution capabilities that can be used for severe weather predictions (e.g., tornado outbreak events and cat-5 hurricanes) and ultra-high-resolution (1-km) regional climate simulations within a consistent global modeling framework. The fundation of this flexible regional-global modeling system is the non-hydrostatic extension of the vertically Lagrangian dynamical core (Lin 2004, Monthly Weather Review) known in the community as FV3 (finite-volume on the cubed-sphere). Because of its flexability and computational efficiency, the FV3 is one of the final candidates of NOAA's Next Generation Global Prediction System (NGGPS). We have built into the modeling system a stretched (single) grid capability, a two-way (regional-global) multiple nested grid capability, and the combination of the stretched and two-way nests, so as to make convection-resolving regional climate simulation within a consistent global modeling system feasible using today's High Performance Computing System. One of our main scientific goals is to enable simulations of high impact weather phenomena (such as tornadoes, thunderstorms, category-5 hurricanes) within an IPCC-class climate modeling system previously regarded as impossible. In this presentation I will demonstrate that it is computationally feasible to simulate not only super-cell thunderstorms, but also the subsequent genesis of tornadoes using a global model that was originally designed for century long climate simulations. As a unified weather-climate modeling system, we evaluated the performance of the model with horizontal resolution ranging from 1 km to as low as 200 km. In particular, for downscaling studies, we have developed various tests to ensure that the large-scale circulation within the global varaible resolution system is well simulated while at the same time the small-scale can be accurately captured within the targeted high resolution region.

  5. Development and Implementation of Metrics for Identifying Military Impulse Noise

    DTIC Science & Technology

    2010-09-01

    False Negative Rate FP False Positive FPR False Positive Rate FtC Fort Carson, CO GIS Geographic Information System GMM Gaussian mixture model Hz...60 70 80 90 100 110 Bin Number B in N um be r N um ber of D ata Points M apped to B in 14 Figure 8. Plot of typical neuron activation...signal metrics and waveform itself were saved and transmitted to the home base. There is also a provision to download the entire recorded waveform

  6. Cognitive Affective Engagement Model of Multiple Source Use

    ERIC Educational Resources Information Center

    List, Alexandra; Alexander, Patricia A.

    2017-01-01

    This article introduces the cognitive affective engagement model (CAEM) of multiple source use. The CAEM is presented as a way of unifying cognitive and behaviorally focused models of multiple text engagement with research on the role of affective factors (e.g., interest) in text processing. The CAEM proposes that students' engagement with…

  7. The Determinants of Student Effort at Learning ERP: A Cultural Perspective

    ERIC Educational Resources Information Center

    Alshare, Khaled A.; El-Masri, Mazen; Lane, Peggy L.

    2015-01-01

    This paper develops a research model based on the Unified Theory of Acceptance and Use of Technology model (UTAUT) and Hofstede's cultural dimensions to explore factors that influence student effort at learning Enterprise Resource Planning (ERP) systems. A Structural Equation Model (SEM) using LISREL was utilized to validate the proposed research…

  8. A Software Hub for High Assurance Model-Driven Development and Analysis

    DTIC Science & Technology

    2007-01-23

    verification of UML models in TLPVS. In Thomas Baar, Alfred Strohmeier, Ana Moreira, and Stephen J. Mellor, editors, UML 2004 - The Unified Modeling...volume 3785 of Lecture Notes in Computer Science, pages 52–65, Manchester, UK, Nov 2005. Springer. [GH04] Günter Graw and Peter Herrmann. Transformation

  9. Towards new-generation soil erosion modeling: Building a unified omnivorous model

    USDA-ARS?s Scientific Manuscript database

    Soil erosion is a global threat to agricultural production, and results in off-site sediment and nutrient losses that negatively impact water and air quality. Models are mathematical equations used to estimate the amount of soil lost from a land air, due to the erosive forces of water or wind. Early...

  10. Higher Education Quality Assessment Model: Towards Achieving Educational Quality Standard

    ERIC Educational Resources Information Center

    Noaman, Amin Y.; Ragab, Abdul Hamid M.; Madbouly, Ayman I.; Khedra, Ahmed M.; Fayoumi, Ayman G.

    2017-01-01

    This paper presents a developed higher education quality assessment model (HEQAM) that can be applied for enhancement of university services. This is because there is no universal unified quality standard model that can be used to assess the quality criteria of higher education institutes. The analytical hierarchy process is used to identify the…

  11. Colaborated Architechture Framework for Composition UML 2.0 in Zachman Framework

    NASA Astrophysics Data System (ADS)

    Hermawan; Hastarista, Fika

    2016-01-01

    Zachman Framework (ZF) is the framework of enterprise architechture that most widely adopted in the Enterprise Information System (EIS) development. In this study, has been developed Colaborated Architechture Framework (CAF) to collaborate ZF with Unified Modeling Language (UML) 2.0 modeling. The CAF provides the composition of ZF matrix that each cell is consist of the Model Driven architechture (MDA) from the various UML models and many Software Requirement Specification (SRS) documents. Implementation of this modeling is used to develops Enterprise Resource Planning (ERP). Because ERP have a coverage of applications in large numbers and complexly relations, it is necessary to use Agile Model Driven Design (AMDD) approach as an advanced method to transforms MDA into components of application modules with efficiently and accurately. Finally, through the using of the CAF, give good achievement in fullfilment the needs from all stakeholders that are involved in the overall process stage of Rational Unified Process (RUP), and also obtaining a high satisfaction to fullfiled the functionality features of the ERP software in PT. Iglas (Persero) Gresik.

  12. Hidden gauged U (1 ) model: Unifying scotogenic neutrino and flavor dark matter

    NASA Astrophysics Data System (ADS)

    Yu, Jiang-Hao

    2016-06-01

    In both scotogenic neutrino and flavor dark matter models, the dark sector communicates with the standard model fermions via Yukawa portal couplings. We propose an economic scenario where the scotogenic neutrino and a flavored mediator share the same inert Higgs doublet and all are charged under a hidden gauged U (1 ) symmetry. The dark Z2 symmetry in the dark sector is regarded as the remnant of this hidden U (1 ) symmetry breaking. In particular, we investigate a dark U (1 )D [and also U (1 )B-L] model which unifies the scotogenic neutrino and top-flavored mediator. Thus dark tops and dark neutrinos are the standard model fermion partners, and the dark matter could be the inert Higgs or the lightest dark neutrino. We note that this model has rich collider signatures on dark tops, the inert Higgs and the Z' gauge boson. Moreover, the scalar associated to the U (1 )D [and also U (1 )B -L ] symmetry breaking could explain the 750 GeV diphoton excess reported by ATLAS and CMS recently.

  13. Evaluation of NCMRWF unified model vertical cloud structure with CloudSat over the Indian summer monsoon region

    NASA Astrophysics Data System (ADS)

    Jayakumar, A.; Mamgain, Ashu; Jisesh, A. S.; Mohandas, Saji; Rakhi, R.; Rajagopal, E. N.

    2016-05-01

    Representation of rainfall distribution and monsoon circulation in the high resolution versions of NCMRWF Unified model (NCUM-REG) for the short-range forecasting of extreme rainfall event is vastly dependent on the key factors such as vertical cloud distribution, convection and convection/cloud relationship in the model. Hence it is highly relevant to evaluate the vertical structure of cloud and precipitation of the model over the monsoon environment. In this regard, we utilized the synergy of the capabilities of CloudSat data for long observational period, by conditioning it for the synoptic situation of the model simulation period. Simulations were run at 4-km grid length with the convective parameterization effectively switched off and on. Since the sample of CloudSat overpasses through the monsoon domain is small, the aforementioned methodology may qualitatively evaluate the vertical cloud structure for the model simulation period. It is envisaged that the present study will open up the possibility of further improvement in the high resolution version of NCUM in the tropics for the Indian summer monsoon associated rainfall events.

  14. Rehabilitation of Cleft Palate: Parents and Professionals, A Unifying Model

    ERIC Educational Resources Information Center

    Pannbacker, Mary; Schneiderman, Carl

    1977-01-01

    Described are commonalities and differences between parents of children with cleft palate and rehabilitation professionals, and offered are suggestions to increase communication and joint effectiveness. (DB)

  15. Super-volcanic investigations

    NASA Astrophysics Data System (ADS)

    Till, Christy B.; Pritchard, Matthew; Miller, Craig A.; Brugman, Karalee K.; Ryan-Davis, Juliet

    2018-04-01

    Multi-disciplinary analyses of Earth's most destructive volcanic systems show that continuous monitoring and an understanding of each volcano's quirks, rather than a single unified model, are key to generating accurate hazard assessments.

  16. Adaptive unified continuum FEM modeling of a 3D FSI benchmark problem.

    PubMed

    Jansson, Johan; Degirmenci, Niyazi Cem; Hoffman, Johan

    2017-09-01

    In this paper, we address a 3D fluid-structure interaction benchmark problem that represents important characteristics of biomedical modeling. We present a goal-oriented adaptive finite element methodology for incompressible fluid-structure interaction based on a streamline diffusion-type stabilization of the balance equations for mass and momentum for the entire continuum in the domain, which is implemented in the Unicorn/FEniCS software framework. A phase marker function and its corresponding transport equation are introduced to select the constitutive law, where the mesh tracks the discontinuous fluid-structure interface. This results in a unified simulation method for fluids and structures. We present detailed results for the benchmark problem compared with experiments, together with a mesh convergence study. Copyright © 2016 John Wiley & Sons, Ltd.

  17. A subsequent closed-form description of propagated signaling phenomena in the membrane of an axon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Melendy, Robert F., E-mail: rfmelendy@liberty.edu

    2016-05-15

    I recently introduced a closed-form description of propagated signaling phenomena in the membrane of an axon [R.F. Melendy, Journal of Applied Physics 118, 244701 (2015)]. Those results demonstrate how intracellular conductance, the thermodynamics of magnetization, and current modulation, function together in generating an action potential in a unified, closed-form description. At present, I report on a subsequent closed-form model that unifies intracellular conductance and the thermodynamics of magnetization, with the membrane electric field, E{sub m}. It’s anticipated this work will compel researchers in biophysics, physical biology, and the computational neurosciences, to probe deeper into the classical and quantum features ofmore » membrane magnetization and signaling, informed by the computational features of this subsequent model.« less

  18. Towards a unified theory of health-disease: II. Holopathogenesis

    PubMed Central

    Almeida-Filho, Naomar

    2014-01-01

    This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease. PMID:24897040

  19. Scientific Communication and the Unified Laboratory Sequence1

    NASA Astrophysics Data System (ADS)

    Silverstein, Todd P.; Hudak, Norman J.; Chapple, Frances H.; Goodney, David E.; Brink, Christina P.; Whitehead, Joyce P.

    1997-02-01

    The "Temperature Dependent Relaxation Kinetics" lab was first implemented in 1987; it uses stopped-flow pH jump techniques to determine rate constants and activation parameters (H, S, G) for a reaction mechanism. Two new experiments (Monoamine Oxidase, and Molecular Modeling) will be implemented in the fall of 1997. The "Monoamine Oxidase" project uses chromatography and spectrophotometry to purify and characterize the enzyme. Subsequent photometric assays explore the enzyme's substrate specificity, activation energy, and denaturation. Finally, in the "Molecular Modeling"project, students characterize enzyme - substrate and drug - receptor interactions. Energy minimization protocols are used to make predictions about protein structure and ligand binding, and to explore pharmacological and biomedical implications. With these additions, the twelve Unified Laboratory projects introduce our chemistry majors to nearly all of the instrumental methods commonly encountered in modern chemistry.

  20. A unified perspective on robot control - The energy Lyapunov function approach

    NASA Technical Reports Server (NTRS)

    Wen, John T.

    1990-01-01

    A unified framework for the stability analysis of robot tracking control is presented. By using an energy-motivated Lyapunov function candidate, the closed-loop stability is shown for a large family of control laws sharing a common structure of proportional and derivative feedback and a model-based feedforward. The feedforward can be zero, partial or complete linearized dynamics, partial or complete nonlinear dynamics, or linearized or nonlinear dynamics with parameter adaptation. As result, the dichotomous approaches to the robot control problem based on the open-loop linearization and nonlinear Lyapunov analysis are both included in this treatment. Furthermore, quantitative estimates of the trade-offs between different schemes in terms of the tracking performance, steady state error, domain of convergence, realtime computation load and required a prior model information are derived.

  1. The Layer-Based, Pragmatic Model of the Communication Process.

    ERIC Educational Resources Information Center

    Targowski, Andrew S.; Bowman, Joel P.

    1988-01-01

    Presents the Targowski/Bowman model of the communication process, which introduces a new paradigm that isolates the various components for individual measurement and analysis, places these components into a unified whole, and places communication and its business component into a larger cultural context. (MM)

  2. Complex networks as a unified framework for descriptive analysis and predictive modeling in climate

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steinhaeuser, Karsten J K; Chawla, Nitesh; Ganguly, Auroop R

    The analysis of climate data has relied heavily on hypothesis-driven statistical methods, while projections of future climate are based primarily on physics-based computational models. However, in recent years a wealth of new datasets has become available. Therefore, we take a more data-centric approach and propose a unified framework for studying climate, with an aim towards characterizing observed phenomena as well as discovering new knowledge in the climate domain. Specifically, we posit that complex networks are well-suited for both descriptive analysis and predictive modeling tasks. We show that the structural properties of climate networks have useful interpretation within the domain. Further,more » we extract clusters from these networks and demonstrate their predictive power as climate indices. Our experimental results establish that the network clusters are statistically significantly better predictors than clusters derived using a more traditional clustering approach. Using complex networks as data representation thus enables the unique opportunity for descriptive and predictive modeling to inform each other.« less

  3. A remote sensing computer-assisted learning tool developed using the unified modeling language

    NASA Astrophysics Data System (ADS)

    Friedrich, J.; Karslioglu, M. O.

    The goal of this work has been to create an easy-to-use and simple-to-make learning tool for remote sensing at an introductory level. Many students struggle to comprehend what seems to be a very basic knowledge of digital images, image processing and image arithmetic, for example. Because professional programs are generally too complex and overwhelming for beginners and often not tailored to the specific needs of a course regarding functionality, a computer-assisted learning (CAL) program was developed based on the unified modeling language (UML), the present standard for object-oriented (OO) system development. A major advantage of this approach is an easier transition from modeling to coding of such an application, if modern UML tools are being used. After introducing the constructed UML model, its implementation is briefly described followed by a series of learning exercises. They illustrate how the resulting CAL tool supports students taking an introductory course in remote sensing at the author's institution.

  4. Health services management modalities in the Brazilian Unified National Health System: a narrative review of research production in Public Health (2005-2016).

    PubMed

    Ravioli, Antonio Franco; Soárez, Patrícia Coelho De; Scheffer, Mário César

    2018-01-01

    The current study aimed to systematically analyze trends and priorities in the theoretical and conceptual approaches and empirical studies on specific health services management modalities in the Brazilian Unified National Health System. A narrative review of the literature identified, in 33 publications, the location and nature of services, management models, methodological procedures, and study outcomes. The research deals mainly with the models' conceptual and legal characteristics and management practices, in addition to addressing contracts, procurement, human resources, financing, and control mechanisms. In conclusion, the literature is limited and concentrated in the State of São Paulo, showing little theoretical diversity and methodological weaknesses, while it is nonconclusive as to the superiority of one management model over another. New evaluation studies are needed that are capable of comparing different models and assessing their performance and their effects on the quality of health services' provision, the population's health, and the health system's organization.

  5. Nonlinear THz Plamonic Disk Resonators

    NASA Astrophysics Data System (ADS)

    Seren, Huseyin; Zhang, Jingdi; Keiser, George; Maddox, Scott; Fan, Kebin; Cao, Lingyue; Bank, Seth; Zhang, Xin; Averitt, Richard

    2013-03-01

    Particle surface plasmons (PPSs) at visible wavelengths continue to be actively investigated with the goal of nanoscale control of light. In contrast, terahertz (THz) surface plasmon experiments are at a nascent stage of investigation. Doped semiconductors with proper carrier density and mobility support THz PSPs. One approach is to utilize thick doped films etched into subwavelength disks. Given the ease of tuning the semiconductor carrier density, THz PSPs are tunable and exhibit interesting nonlinear THz plasmonic effects. We created THz PSP structures using MBE grown 2um thick InAs films with a doping concentration of 1e17cm-3 on 500um thick semi-insulating GaAs substrate. We patterned 40um diameter disks with a 60um period by reactive ion etching. Our THz time-domain measurements reveal a resonance at 1.1THz which agrees well with simulation results using a Drude model. A nonlinear response occurs at high THz electric field strengths (>50kV/cm). In particular, we observed a redshift and quenching of the resonance due to impact ionization which resulted in changes in the carrier density and effective mass due to inter-valley scattering.

  6. Implicit gas-kinetic unified algorithm based on multi-block docking grid for multi-body reentry flows covering all flow regimes

    NASA Astrophysics Data System (ADS)

    Peng, Ao-Ping; Li, Zhi-Hui; Wu, Jun-Lin; Jiang, Xin-Yu

    2016-12-01

    Based on the previous researches of the Gas-Kinetic Unified Algorithm (GKUA) for flows from highly rarefied free-molecule transition to continuum, a new implicit scheme of cell-centered finite volume method is presented for directly solving the unified Boltzmann model equation covering various flow regimes. In view of the difficulty in generating the single-block grid system with high quality for complex irregular bodies, a multi-block docking grid generation method is designed on the basis of data transmission between blocks, and the data structure is constructed for processing arbitrary connection relations between blocks with high efficiency and reliability. As a result, the gas-kinetic unified algorithm with the implicit scheme and multi-block docking grid has been firstly established and used to solve the reentry flow problems around the multi-bodies covering all flow regimes with the whole range of Knudsen numbers from 10 to 3.7E-6. The implicit and explicit schemes are applied to computing and analyzing the supersonic flows in near-continuum and continuum regimes around a circular cylinder with careful comparison each other. It is shown that the present algorithm and modelling possess much higher computational efficiency and faster converging properties. The flow problems including two and three side-by-side cylinders are simulated from highly rarefied to near-continuum flow regimes, and the present computed results are found in good agreement with the related DSMC simulation and theoretical analysis solutions, which verify the good accuracy and reliability of the present method. It is observed that the spacing of the multi-body is smaller, the cylindrical throat obstruction is greater with the flow field of single-body asymmetrical more obviously and the normal force coefficient bigger. While in the near-continuum transitional flow regime of near-space flying surroundings, the spacing of the multi-body increases to six times of the diameter of the single-body, the interference effects of the multi-bodies tend to be negligible. The computing practice has confirmed that it is feasible for the present method to compute the aerodynamics and reveal flow mechanism around complex multi-body vehicles covering all flow regimes from the gas-kinetic point of view of solving the unified Boltzmann model velocity distribution function equation.

  7. Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lynch, Caitlin; Pan, Yongmei; Li, Linhao

    Objective: Accumulating evidence suggests that activation of mouse constitutive androstane receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic gluconeogenesis, lipogenesis, and fatty acid synthesis. However, the role of human (h) CAR in energy metabolism is largely unknown. The present study aims to investigate the effects of selective hCAR activators on hepatic energy metabolism in human primary hepatocytes (HPH). Methods: Ligand-based structure–activity models were used for virtual screening of the Specs database ( (www.specs.net)) followed by biological validation in cell-based luciferase assays. The effects of two novel hCAR activators (UM104 and UM145) on hepatic energy metabolism were evaluatedmore » in HPH. Results: Real-time PCR and Western blotting analyses reveal that activation of hCAR by UM104 and UM145 significantly repressed the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, two pivotal gluconeogenic enzymes, while exerting negligible effects on the expression of genes associated with lipogenesis and fatty acid synthesis. Functional experiments show that UM104 and UM145 markedly inhibit hepatic synthesis of glucose but not triglycerides in HPH. In contrast, activation of mCAR by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a selective mCAR activator, repressed the expression of genes associated with gluconeogenesis, lipogenesis, and fatty acid synthesis in mouse primary hepatocytes, which were consistent with previous observations in mouse model in vivo. Conclusion: Our findings uncover an important species difference between hCAR and mCAR in hepatic energy metabolism, where hCAR selectively inhibits gluconeogenesis without suppressing fatty acid synthesis. Implications: Such species selectivity should be considered when exploring CAR as a potential therapeutic target for metabolic disorders. - Highlights: • Novel hCAR activators were identified by computational and biological approaches. • The role of hCAR in hepatic energy metabolism was examined. • hCAR activators repress gluconeogenesis but not lipogenesis and fatty acid synthesis. • Human and mouse CAR exhibit differential effects on energy metabolism.« less

  8. Estimated costs of advanced lung cancer care in a public reference hospital.

    PubMed

    Knust, Renata Erthal; Portela, Margareth Crisóstomo; Pereira, Claudia Cristina de Aguiar; Fortes, Guilherme Bastos

    2017-08-17

    To estimate the direct medical costs of advanced non-small cell lung cancer care. We assessed a cohort of 277 patients treated in the Brazilian National Cancer Institute in 2011. The costs were estimated from the perspective of the hospital as a service provider of reference for the Brazilian Unified Health System. The materials and procedures used were identified and quantified, per patient, and we assigned to them monetary values, consolidated in phases of the assistance defined. The analyses had a descriptive character with costs in Real (R$). Overall, the cohort represented a cost of R$2,473,559.91, being 71.5% related to outpatient care and 28.5% to hospitalizations. In the outpatient care, costs with radiotherapy (34%) and chemotherapy (22%) predominated. The results pointed to lower costs in the initial phase of treatment (7.2%) and very high costs in the maintenance phase (61.6%). Finally, we identified statistically significant differences of average cost by age groups, education levels, physical performance, and histological type. This study provides a current, useful, and relevant picture of the costs of patients with non-small cell lung cancer treated in a public hospital of reference and it provides information on the magnitude of the problem of cancer in the context of public health. The results confirm the importance of radiation treatment and hospitalizations as the main components of the cost of treatment. Despite some losses of follow-up, we assess that, for approximately 80% of the patients included in the study, the estimates presented herein are satisfactory for the care of the disease, from the perspective of a service provider of reference of the Brazilian Unified Health System, as it provides elements for the management of the service, as well as for studies that result in more rational forms of resource allocation. Estimar os custos médicos diretos da assistência ao câncer de pulmão não pequenas células avançado. Foi avaliada uma coorte de 277 pacientes matriculados no Instituto Nacional do Câncer em 2011. Os custos foram estimados sob a perspectiva do hospital como prestador de serviços de referência para o SUS. Insumos e procedimentos utilizados foram identificados e quantificados, por paciente, sendo a eles atribuídos valores monetários, consolidados por fases da assistência definidas. As análises tiveram caráter descritivo com custos em reais (R$). Em termos globais, a coorte representou um custo de R$2.473.559,91, sendo 71,5% relacionados à atenção ambulatorial e 28,5% as internações. Na atenção ambulatorial, predominaram os custos com radioterapia (34%) e quimioterapia (22%). Os resultados apontaram para custos menores na fase inicial de tratamento (7,2%) e custos muito elevados na fase de manutenção (61,6%). Por fim, identificaram-se diferenças estatisticamente significativas das médias dos custos por faixas etárias, níveis de escolaridade, desempenho físico e tipo histológico. Este estudo fornece um retrato atual, útil e relevante sobre os custos de pacientes com câncer de pulmão não pequenas células assistidos em um hospital público de referência e provê elementos sobre a magnitude do problema do câncer no âmbito da saúde pública. Os resultados ratificam a importância do tratamento radioterápico e das internações como principais componentes de custo do tratamento. Apesar de algumas perdas de seguimento avalia-se que, para cerca de 80% dos pacientes incluídos no estudo, as estimativas aqui apresentadas sejam satisfatoriamente fidedignas ao cuidado da doença, sob a perspectiva de um prestador de referência do SUS, fornecendo elementos para a gestão do serviço, bem como para estudos que redundem em formas mais racionais de alocação de recursos.

  9. The establishment of insulin resistance model in FL83B and L6 cell

    NASA Astrophysics Data System (ADS)

    Liu, Lanlan; Han, Jizhong; Li, Haoran; Liu, Mengmeng; Zeng, Bin

    2017-10-01

    The insulin resistance models of mouse liver epithelial and rat myoblasts cells were induced by three kinds of inducers: dexamethasone, high insulin and high glucose. The purpose is to select the optimal insulin resistance model, to provide a simple and reliable TR cell model for the study of the pathogenesis of TR and the improvement of TR drugs and functional foods. The MTT method is used for toxicity screening of three compounds, selecting security and suitable concentration. We performed a Glucose oxidase peroxidase (GOD-POD) method involving FL83B and L6 cell with dexamethasone, high insulin and high glucose-induced insulin resistance. Results suggested that FL83B cells with dexamethasone-induced (0.25uM) were established insulin resistance and L6 cells with high-glucose (30mM) and dexamethasone-induced (0.25uM) were established insulin resistance.

  10. A Novel Strategy to Inhibit Hedgehog Signaling and Control Growth of Androgen-Independent Prostate Cancer Cells

    DTIC Science & Technology

    2013-12-01

    M TIME PPC1 Volume of Spheroid Ctrl (respective media) .2% DMSO 10 uM Free Curcumin 20 uM Free Curcumin 10 uM Tagged Curcumin 20 uM Tagged... Curcumin FIGURE 6 Ctrl media 10uM FC 20uM FC 20uM TC 10uM TC 2% DMSO PC3 t0 Div 8 FIGURE 7 Phospho-p65 NFκB subunit expression decreased In

  11. The Development of Web-based Graphical User Interface for Unified Modeling Data with Multi (Correlated) Responses

    NASA Astrophysics Data System (ADS)

    Made Tirta, I.; Anggraeni, Dian

    2018-04-01

    Statistical models have been developed rapidly into various directions to accommodate various types of data. Data collected from longitudinal, repeated measured, clustered data (either continuous, binary, count, or ordinal), are more likely to be correlated. Therefore statistical model for independent responses, such as Generalized Linear Model (GLM), Generalized Additive Model (GAM) are not appropriate. There are several models available to apply for correlated responses including GEEs (Generalized Estimating Equations), for marginal model and various mixed effect model such as GLMM (Generalized Linear Mixed Models) and HGLM (Hierarchical Generalized Linear Models) for subject spesific models. These models are available on free open source software R, but they can only be accessed through command line interface (using scrit). On the othe hand, most practical researchers very much rely on menu based or Graphical User Interface (GUI). We develop, using Shiny framework, standard pull down menu Web-GUI that unifies most models for correlated responses. The Web-GUI has accomodated almost all needed features. It enables users to do and compare various modeling for repeated measure data (GEE, GLMM, HGLM, GEE for nominal responses) much more easily trough online menus. This paper discusses the features of the Web-GUI and illustrates the use of them. In General we find that GEE, GLMM, HGLM gave very closed results.

  12. Pedagogical Issues in Object Orientation.

    ERIC Educational Resources Information Center

    Nerur, Sridhar; Ramanujan, Sam; Kesh, Someswar

    2002-01-01

    Discusses the need for people with object-oriented (OO) skills, explains benefits of OO in software development, and addresses some of the difficulties in teaching OO. Topics include the evolution of programming languages; differences between OO and traditional approaches; differences from data modeling; and Unified Modeling Language (UML) and…

  13. Analysis of Predicted Aircraft Wake Vortex Transport and Comparison with Experiment Volume I -- Wake Vortex Predictive System Study

    DOT National Transportation Integrated Search

    1974-04-01

    A unifying wake vortex transport model is developed and applied to a wake vortex predictive system concept. The fundamentals of vortex motion underlying the predictive model are discussed including vortex decay, bursting and instability phenomena. A ...

  14. Reconciling Time, Space and Function: A New Dorsal-Ventral Stream Model of Sentence Comprehension

    ERIC Educational Resources Information Center

    Bornkessel-Schlesewsky, Ina; Schlesewsky, Matthias

    2013-01-01

    We present a new dorsal-ventral stream framework for language comprehension which unifies basic neurobiological assumptions (Rauschecker & Scott, 2009) with a cross-linguistic neurocognitive sentence comprehension model (eADM; Bornkessel & Schlesewsky, 2006). The dissociation between (time-dependent) syntactic structure-building and…

  15. Stochastic nonlinear dynamics pattern formation and growth models

    PubMed Central

    Yaroslavsky, Leonid P

    2007-01-01

    Stochastic evolutionary growth and pattern formation models are treated in a unified way in terms of algorithmic models of nonlinear dynamic systems with feedback built of a standard set of signal processing units. A number of concrete models is described and illustrated by numerous examples of artificially generated patterns that closely imitate wide variety of patterns found in the nature. PMID:17908341

  16. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2010-01-01

    A multi-scale modeling system with unified physics has been developed at NASA Goddard Space Flight Center (GSFC). The system consists of an MMF, the coupled NASA Goddard finite-volume GCM (fvGCM) and Goddard Cumulus Ensemble model (GCE, a CRM); the state-of-the-art Weather Research and Forecasting model (WRF) and the stand alone GCE. These models can share the same microphysical schemes, radiation (including explicitly calculated cloud optical properties), and surface models that have been developed, improved and tested for different environments. In this talk, I will present: (1) A brief review on GCE model and its applications on the impact of the aerosol on deep precipitation processes, (2) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) A discussion on the Goddard WRF version (its developments and applications). We are also performing the inline tracer calculation to comprehend the physical processes (i.e., boundary layer and each quadrant in the boundary layer) related to the development and structure of hurricanes and mesoscale convective systems. In addition, high - resolution (spatial. 2km, and temporal, I minute) visualization showing the model results will be presented.

  17. A comprehensive model on field-effect pnpn devices (Z2-FET)

    NASA Astrophysics Data System (ADS)

    Taur, Yuan; Lacord, Joris; Parihar, Mukta Singh; Wan, Jing; Martinie, Sebastien; Lee, Kyunghwa; Bawedin, Maryline; Barbe, Jean-Charles; Cristoloveanu, Sorin

    2017-08-01

    A comprehensive model for field-effect pnpn devices (Z2-FET) is presented. It is based on three current continuity equations coupled to two MOS equations. The model reproduces the characteristic S-shaped I-V curve when the device is driven by a current source. The negative resistance region at intermediate currents occurs as the center junction undergoes a steep transition from reverse to forward bias. Also playing a vital role are the mix and match of the minority carrier diffusion current and the generation recombination current. Physical insights to the key mechanisms at work are gained by regional approximations of the model, from which analytical expressions for the maximum and minimum voltages at the switching points are derived. From 1981 to 2001, he was with the Silicon Technology Department of IBM Thomas J. Watson Research Center, Yorktown Heights, New York, where he was Manager of Exploratory Devices and Processes. Areas in which he has worked and published include latchup-free 1-um CMOS, self-aligned TiSi2, 0.5-um CMOS and BiCMOS, shallow trench isolation, 0.25-um CMOS with n+/p + poly gates, SOI, low-temperature CMOS, and 0.1-um CMOS. Since October 2001, he has been a professor in the Department of Electrical and Computer Engineering, University of California, San Diego. Dr. Yuan Taur was elected a Fellow of the IEEE in 1998. He has served as Editor-in-Chief of the IEEE Electron Device Letters from 1999 to 2011. He authored or co-authored over 200 technical papers and holds 14 U.S. patents. He co-authored a book, ;Fundamentals of Modern VLSI Devices,; published by Cambridge University Press in 1998. The 2nd edition was published in 2009. Dr. Yuan Taur received IEEE Electron Devices Society's J. J. Ebers Award in 2012 ;for contributions to the advancement of several generations of CMOS process technologies.;

  18. Gas-kinetic unified algorithm for hypersonic flows covering various flow regimes solving Boltzmann model equation in nonequilibrium effect

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Zhihui; Ma, Qiang; Wu, Junlin

    2014-12-09

    Based on the Gas-Kinetic Unified Algorithm (GKUA) directly solving the Boltzmann model equation, the effect of rotational non-equilibrium is investigated recurring to the kinetic Rykov model with relaxation property of rotational degrees of freedom. The spin movement of diatomic molecule is described by moment of inertia, and the conservation of total angle momentum is taken as a new Boltzmann collision invariant. The molecular velocity distribution function is integrated by the weight factor on the internal energy, and the closed system of two kinetic controlling equations is obtained with inelastic and elastic collisions. The optimization selection technique of discrete velocity ordinatemore » points and numerical quadrature rules for macroscopic flow variables with dynamic updating evolvement are developed to simulate hypersonic flows, and the gas-kinetic numerical scheme is constructed to capture the time evolution of the discretized velocity distribution functions. The gas-kinetic boundary conditions in thermodynamic non-equilibrium and numerical procedures are studied and implemented by directly acting on the velocity distribution function, and then the unified algorithm of Boltzmann model equation involving non-equilibrium effect is presented for the whole range of flow regimes. The hypersonic flows involving non-equilibrium effect are numerically simulated including the inner flows of shock wave structures in nitrogen with different Mach numbers of 1.5-Ma-25, the planar ramp flow with the whole range of Knudsen numbers of 0.0009-Kn-10 and the three-dimensional re-entering flows around tine double-cone body.« less

  19. Successful N{sub 2} leptogenesis with flavour coupling effects in realistic unified models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bari, Pasquale Di; King, Stephen F.

    2015-10-02

    In realistic unified models involving so-called SO(10)-inspired patterns of Dirac and heavy right-handed (RH) neutrino masses, the lightest right-handed neutrino N{sub 1} is too light to yield successful thermal leptogenesis, barring highly fine tuned solutions, while the second heaviest right-handed neutrino N{sub 2} is typically in the correct mass range. We show that flavour coupling effects in the Boltzmann equations may be crucial to the success of such N{sub 2} dominated leptogenesis, by helping to ensure that the flavour asymmetries produced at the N{sub 2} scale survive N{sub 1} washout. To illustrate these effects we focus on N{sub 2} dominatedmore » leptogenesis in an existing model, the A to Z of flavour with Pati-Salam, where the neutrino Dirac mass matrix may be equal to an up-type quark mass matrix and has a particular constrained structure. The numerical results, supported by analytical insight, show that in order to achieve successful N{sub 2} leptogenesis, consistent with neutrino phenomenology, requires a “flavour swap scenario” together with a less hierarchical pattern of RH neutrino masses than naively expected, at the expense of some mild fine-tuning. In the considered A to Z model neutrino masses are predicted to be normal ordered, with an atmospheric neutrino mixing angle well into the second octant and the Dirac phase δ≃20{sup ∘}, a set of predictions that will be tested in the next years in neutrino oscillation experiments. Flavour coupling effects may be relevant for other SO(10)-inspired unified models where N{sub 2} leptogenesis is necessary.« less

  20. Successful N{sub 2} leptogenesis with flavour coupling effects in realistic unified models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bari, Pasquale Di; King, Stephen F., E-mail: P.Di-Bari@soton.ac.uk, E-mail: king@soton.ac.uk

    2015-10-01

    In realistic unified models involving so-called SO(10)-inspired patterns of Dirac and heavy right-handed (RH) neutrino masses, the lightest right-handed neutrino N{sub 1} is too light to yield successful thermal leptogenesis, barring highly fine tuned solutions, while the second heaviest right-handed neutrino N{sub 2} is typically in the correct mass range. We show that flavour coupling effects in the Boltzmann equations may be crucial to the success of such N{sub 2} dominated leptogenesis, by helping to ensure that the flavour asymmetries produced at the N{sub 2} scale survive N{sub 1} washout. To illustrate these effects we focus on N{sub 2} dominatedmore » leptogenesis in an existing model, the A to Z of flavour with Pati-Salam, where the neutrino Dirac mass matrix may be equal to an up-type quark mass matrix and has a particular constrained structure. The numerical results, supported by analytical insight, show that in order to achieve successful N{sub 2} leptogenesis, consistent with neutrino phenomenology, requires a ''flavour swap scenario'' together with a less hierarchical pattern of RH neutrino masses than naively expected, at the expense of some mild fine-tuning. In the considered A to Z model neutrino masses are predicted to be normal ordered, with an atmospheric neutrino mixing angle well into the second octant and the Dirac phase δ≅ 20{sup o}, a set of predictions that will be tested in the next years in neutrino oscillation experiments. Flavour coupling effects may be relevant for other SO(10)-inspired unified models where N{sub 2} leptogenesis is necessary.« less

  1. Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects.

    PubMed

    Krasovitski, Boris; Frenkel, Victor; Shoham, Shy; Kimmel, Eitan

    2011-02-22

    The purpose of this study was to develop a unified model capable of explaining the mechanisms of interaction of ultrasound and biological tissue at both the diagnostic nonthermal, noncavitational (<100 mW · cm(-2)) and therapeutic, potentially cavitational (>100 mW · cm(-2)) spatial peak temporal average intensity levels. The cellular-level model (termed "bilayer sonophore") combines the physics of bubble dynamics with cell biomechanics to determine the dynamic behavior of the two lipid bilayer membrane leaflets. The existence of such a unified model could potentially pave the way to a number of controlled ultrasound-assisted applications, including CNS modulation and blood-brain barrier permeabilization. The model predicts that the cellular membrane is intrinsically capable of absorbing mechanical energy from the ultrasound field and transforming it into expansions and contractions of the intramembrane space. It further predicts that the maximum area strain is proportional to the acoustic pressure amplitude and inversely proportional to the square root of the frequency (ε A,max ∝ P(A)(0.8f - 0.5) and is intensified by proximity to free surfaces, the presence of nearby microbubbles in free medium, and the flexibility of the surrounding tissue. Model predictions were experimentally supported using transmission electron microscopy (TEM) of multilayered live-cell goldfish epidermis exposed in vivo to continuous wave (CW) ultrasound at cavitational (1 MHz) and noncavitational (3 MHz) conditions. Our results support the hypothesis that ultrasonically induced bilayer membrane motion, which does not require preexistence of air voids in the tissue, may account for a variety of bioeffects and could elucidate mechanisms of ultrasound interaction with biological tissue that are currently not fully understood.

  2. Multilayer network of language: A unified framework for structural analysis of linguistic subsystems

    NASA Astrophysics Data System (ADS)

    Martinčić-Ipšić, Sanda; Margan, Domagoj; Meštrović, Ana

    2016-09-01

    Recently, the focus of complex networks' research has shifted from the analysis of isolated properties of a system toward a more realistic modeling of multiple phenomena - multilayer networks. Motivated by the prosperity of multilayer approach in social, transport or trade systems, we introduce the multilayer networks for language. The multilayer network of language is a unified framework for modeling linguistic subsystems and their structural properties enabling the exploration of their mutual interactions. Various aspects of natural language systems can be represented as complex networks, whose vertices depict linguistic units, while links model their relations. The multilayer network of language is defined by three aspects: the network construction principle, the linguistic subsystem and the language of interest. More precisely, we construct a word-level (syntax and co-occurrence) and a subword-level (syllables and graphemes) network layers, from four variations of original text (in the modeled language). The analysis and comparison of layers at the word and subword-levels are employed in order to determine the mechanism of the structural influences between linguistic units and subsystems. The obtained results suggest that there are substantial differences between the networks' structures of different language subsystems, which are hidden during the exploration of an isolated layer. The word-level layers share structural properties regardless of the language (e.g. Croatian or English), while the syllabic subword-level expresses more language dependent structural properties. The preserved weighted overlap quantifies the similarity of word-level layers in weighted and directed networks. Moreover, the analysis of motifs reveals a close topological structure of the syntactic and syllabic layers for both languages. The findings corroborate that the multilayer network framework is a powerful, consistent and systematic approach to model several linguistic subsystems simultaneously and hence to provide a more unified view on language.

  3. Cogenerating and pre-annihilating dark matter by a new gauge interaction in a unified model

    DOE PAGES

    Barr, S. M.; Scherrer, Robert J.

    2016-05-31

    Here, grand unified theories based on large groups (with rank ≥ 6) are a natural context for dark matter models. They contain Standard-Model-singlet fermions that could be dark matter candidates, and can contain new non-abelian interactions whose sphalerons convert baryons, leptons, and dark matter into each other, ''cogenerating" a dark matter asymmetry comparable to the baryon asymmetry. In this paper it is shown that the same non-abelian interactions can ''pre-annihilate" the symmetric component of heavy dark matter particles χ, which then decay late into light stable dark matter particles ζ that inherit their asymmetry. We derive cosmological constraints on themore » parameters of such models. The mass of χ must be < 3000 TeV and their decays must happen when 2 × 10 –7 < T dec/mχ < 10 –4. It is shown that such decays can come from d=5 operators with coefficients of order 1/MGUT or 1/M Pℓ. We present a simple realization of our model based on the group SU(7).« less

  4. Regularized variational theories of fracture: A unified approach

    NASA Astrophysics Data System (ADS)

    Freddi, Francesco; Royer-Carfagni, Gianni

    2010-08-01

    The fracture pattern in stressed bodies is defined through the minimization of a two-field pseudo-spatial-dependent functional, with a structure similar to that proposed by Bourdin-Francfort-Marigo (2000) as a regularized approximation of a parent free-discontinuity problem, but now considered as an autonomous model per se. Here, this formulation is altered by combining it with structured deformation theory, to model that when the material microstructure is loosened and damaged, peculiar inelastic (structured) deformations may occur in the representative volume element at the price of surface energy consumption. This approach unifies various theories of failure because, by simply varying the form of the class for admissible structured deformations, different-in-type responses can be captured, incorporating the idea of cleavage, deviatoric, combined cleavage-deviatoric and masonry-like fractures. Remarkably, this latter formulation rigorously avoid material overlapping in the cracked zones. The model is numerically implemented using a standard finite-element discretization and adopts an alternate minimization algorithm, adding an inequality constraint to impose crack irreversibility ( fixed crack model). Numerical experiments for some paradigmatic examples are presented and compared for various possible versions of the model.

  5. Viscoplasticity based on overstress with a differential growth law for the equilibrium stress

    NASA Technical Reports Server (NTRS)

    Krempl, E.; Mcmahon, J. J.; Yao, D.

    1985-01-01

    Two coupled, nonlinear differential equations are proposed for the modeling of the elastic and rate (time) dependent inelastic behavior of structural metals in the absence of recovery and aging. The structure of the model is close to the unified theories but contains essential differences. It is shown that the model reproduces almost elastic regions upon initial loading and in the unloading regions of the hysteresis loop. Under loading, unloading and reloading in strain control the model simulated the experimentally observed sharp transition from nearly elastic to inelastic behavior. When a formulation akin to existing unified theories is adopted the almost elastic regions reduce the points and the transition upon reloading is very gradual. For different formulations the behavior under sudden in(de)creases of the strain rate by two orders of magnitude is simulated by numerical experiments and differences are noted. The model represents cyclically neutral behavior and contains three constants and two positive, decreasing functions. The determination of constants and functions from monotonic loading with strain rate changes and relaxation periods is described.

  6. Spray Combustion Modeling with VOF and Finite-Rate Chemistry

    NASA Technical Reports Server (NTRS)

    Chen, Yen-Sen; Shang, Huan-Min; Liaw, Paul; Wang, Ten-See

    1996-01-01

    A spray atomization and combustion model is developed based on the volume-of-fluid (VOF) transport equation with finite-rate chemistry model. The gas-liquid interface mass, momentum and energy conservation laws are modeled by continuum surface force mechanisms. A new solution method is developed such that the present VOF model can be applied for all-speed range flows. The objectives of the present study are: (1) to develop and verify the fractional volume-of-fluid (VOF) cell partitioning approach into a predictor-corrector algorithm to deal with multiphase (gas-liquid) free surface flow problems; (2) to implement the developed unified algorithm in a general purpose computational fluid dynamics (CFD) code, Finite Difference Navier-Stokes (FDNS), with droplet dynamics and finite-rate chemistry models; and (3) to demonstrate the effectiveness of the present approach by simulating benchmark problems of jet breakup/spray atomization and combustion. Modeling multiphase fluid flows poses a significant challenge because a required boundary must be applied to a transient, irregular surface that is discontinuous, and the flow regimes considered can range from incompressible to highspeed compressible flows. The flow-process modeling is further complicated by surface tension, interfacial heat and mass transfer, spray formation and turbulence, and their interactions. The major contribution of the present method is to combine the novel feature of the Volume of Fluid (VOF) method and the Eulerian/Lagrangian method into a unified algorithm for efficient noniterative, time-accurate calculations of multiphase free surface flows valid at all speeds. The proposed method reformulated the VOF equation to strongly couple two distinct phases (liquid and gas), and tracks droplets on a Lagrangian frame when spray model is required, using a unified predictor-corrector technique to account for the non-linear linkages through the convective contributions of VOF. The discontinuities within the sharp interface will be modeled as a volume force to avoid stiffness. Formations of droplets, tracking of droplet dynamics and modeling of the droplet breakup/evaporation, are handled through the same unified predictor-corrector procedure. Thus the new algorithm is non-iterative and is flexible for general geometries with arbitrarily complex topology in free surfaces. The FDNS finite-difference Navier-Stokes code is employed as the baseline of the current development. Benchmark test cases of shear coaxial LOX/H2 liquid jet with atomization/combustion and impinging jet test cases are investigated in the present work. Preliminary data comparisons show good qualitative agreement between data and the present analysis. It is indicative from these results that the present method has great potential to become a general engineering design analysis and diagnostics tool for problems involving spray combustion.

  7. A unified framework for unraveling the functional interaction structure of a biomolecular network based on stimulus-response experimental data.

    PubMed

    Cho, Kwang-Hyun; Choo, Sang-Mok; Wellstead, Peter; Wolkenhauer, Olaf

    2005-08-15

    We propose a unified framework for the identification of functional interaction structures of biomolecular networks in a way that leads to a new experimental design procedure. In developing our approach, we have built upon previous work. Thus we begin by pointing out some of the restrictions associated with existing structure identification methods and point out how these restrictions may be eased. In particular, existing methods use specific forms of experimental algebraic equations with which to identify the functional interaction structure of a biomolecular network. In our work, we employ an extended form of these experimental algebraic equations which, while retaining their merits, also overcome some of their disadvantages. Experimental data are required in order to estimate the coefficients of the experimental algebraic equation set associated with the structure identification task. However, experimentalists are rarely provided with guidance on which parameters to perturb, and to what extent, to perturb them. When a model of network dynamics is required then there is also the vexed question of sample rate and sample time selection to be resolved. Supplying some answers to these questions is the main motivation of this paper. The approach is based on stationary and/or temporal data obtained from parameter perturbations, and unifies the previous approaches of Kholodenko et al. (PNAS 99 (2002) 12841-12846) and Sontag et al. (Bioinformatics 20 (2004) 1877-1886). By way of demonstration, we apply our unified approach to a network model which cannot be properly identified by existing methods. Finally, we propose an experiment design methodology, which is not limited by the amount of parameter perturbations, and illustrate its use with an in numero example.

  8. Global Weather Prediction and High-End Computing at NASA

    NASA Technical Reports Server (NTRS)

    Lin, Shian-Jiann; Atlas, Robert; Yeh, Kao-San

    2003-01-01

    We demonstrate current capabilities of the NASA finite-volume General Circulation Model an high-resolution global weather prediction, and discuss its development path in the foreseeable future. This model can be regarded as a prototype of a future NASA Earth modeling system intended to unify development activities cutting across various disciplines within the NASA Earth Science Enterprise.

  9. System Models of Information, Communication and Mass Communication: Revaluation of Some Basic Concepts of Communication.

    ERIC Educational Resources Information Center

    Wiio, Osmo A.

    A more unified approach to communication theory can evolve through systems modeling of information theory, communication modes, and mass media operations. Such systematic analysis proposes, as is the case care here, that information models be based upon combinations of energy changes and exchanges and changes in receiver systems. The mass media is…

  10. Comparison of postbuckling model and finite element model with compression strength of corrugated boxes

    Treesearch

    Thomas J. Urbanik; Edmond P. Saliklis

    2002-01-01

    Conventional compression strength formulas for corrugated fiberboard boxes are limited to geometry and material that produce an elastic postbuckling failure. Inelastic postbuckling can occur in squatty boxes and trays, but a mechanistic rationale for unifying observed strength data is lacking. This study employs a finite element model, instead of actual experiments, to...

  11. Dataflow models for fault-tolerant control systems

    NASA Technical Reports Server (NTRS)

    Papadopoulos, G. M.

    1984-01-01

    Dataflow concepts are used to generate a unified hardware/software model of redundant physical systems which are prone to faults. Basic results in input congruence and synchronization are shown to reduce to a simple model of data exchanges between processing sites. Procedures are given for the construction of congruence schemata, the distinguishing features of any correctly designed redundant system.

  12. A Unified Approach to Optimization

    DTIC Science & Technology

    2014-10-02

    employee scheduling, ad placement, latin squares, disjunctions of linear systems, temporal modeling with interval variables, and traveling salesman problems ...integrating technologies. A key to integrated modeling is to formulate a problem with high-levelmetaconstraints, which are inspired by the “global... problem substructure to the solver. This contrasts with the atomistic modeling style of mixed integer programming (MIP) and satisfiability (SAT) solvers

  13. Models and parameters for environmental radiological assessments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, C W

    1984-01-01

    This book presents a unified compilation of models and parameters appropriate for assessing the impact of radioactive discharges to the environment. Models examined include those developed for the prediction of atmospheric and hydrologic transport and deposition, for terrestrial and aquatic food-chain bioaccumulation, and for internal and external dosimetry. Chapters have been entered separately into the data base. (ACR)

  14. A Unified Approach to Model-Based Planning and Execution

    NASA Technical Reports Server (NTRS)

    Muscettola, Nicola; Dorais, Gregory A.; Fry, Chuck; Levinson, Richard; Plaunt, Christian; Norvig, Peter (Technical Monitor)

    2000-01-01

    Writing autonomous software is complex, requiring the coordination of functionally and technologically diverse software modules. System and mission engineers must rely on specialists familiar with the different software modules to translate requirements into application software. Also, each module often encodes the same requirement in different forms. The results are high costs and reduced reliability due to the difficulty of tracking discrepancies in these encodings. In this paper we describe a unified approach to planning and execution that we believe provides a unified representational and computational framework for an autonomous agent. We identify the four main components whose interplay provides the basis for the agent's autonomous behavior: the domain model, the plan database, the plan running module, and the planner modules. This representational and problem solving approach can be applied at all levels of the architecture of a complex agent, such as Remote Agent. In the rest of the paper we briefly describe the Remote Agent architecture. The new agent architecture proposed here aims at achieving the full Remote Agent functionality. We then give the fundamental ideas behind the new agent architecture and point out some implication of the structure of the architecture, mainly in the area of reactivity and interaction between reactive and deliberative decision making. We conclude with related work and current status.

  15. A unified model of supernova driven by magnetic monopoles

    NASA Astrophysics Data System (ADS)

    Peng, Qiu-He; Liu, Jing-Jing; Chou, Chih-Kang

    2017-12-01

    In this paper, we first discuss a series of important but puzzling physical mechanisms concerning the energy source, various kinds of core collapsed supernovae explosion mechanisms during central gravitational collapse in astrophysics. We also discuss the puzzle of possible association of γ -ray burst with gravitational wave perturbation, the heat source for the molten interior of the core of the Earth and finally the puzzling problem of the cooling of white dwarfs. We then make use of the estimations for the space flux of magnetic monopoles (hereafter MMs) and nucleon decay induced by MMs (called the Rubakov-Callen (RC) effect) to obtain the luminosity due to the RC effect. In terms of the formula for this RC luminosity, we present a unified treatment for the heat source of the Earth's core, the energy source for the white dwarf interior, various kinds of core collapsed supernovae (Type II Supernova (SNII), Type Ib Supernova (SNIb), Type Ic Supernova (SNIc), Super luminous supernova (SLSN)), and the production mechanism for γ -ray burst. This unified model can also be used to reasonably explain the possible association of the short γ -ray burst detected by the Fermi γ -ray Burst Monitoring Satellite (GBM) with the LIGO gravitational wave event GW150914 in September 2015.

  16. Fitting the Reduced RUM with Mplus: A Tutorial

    ERIC Educational Resources Information Center

    Chiu, Chia-Yi; Köhn, Hans-Friedrich; Wu, Huey-Min

    2016-01-01

    The Reduced Reparameterized Unified Model (Reduced RUM) is a diagnostic classification model for educational assessment that has received considerable attention among psychometricians. However, the computational options for researchers and practitioners who wish to use the Reduced RUM in their work, but do not feel comfortable writing their own…

  17. MODELING DIFFUSION AND REACTION IN SOILS: X. A UNIFYING MODEL FOR SOLUTE AND GAS DIFFUSIVITY IN UNSATURATED SOIL. (R825433)

    EPA Science Inventory

    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

  18. Modelling and Implementation of Catalogue Cards Using FreeMarker

    ERIC Educational Resources Information Center

    Radjenovic, Jelen; Milosavljevic, Branko; Surla, Dusan

    2009-01-01

    Purpose: The purpose of this paper is to report on a study involving the specification (using Unified Modelling Language (UML) 2.0) of information requirements and implementation of the software components for generating catalogue cards. The implementation in a Java environment is developed using the FreeMarker software.…

  19. Standing at the Intersection: Reconsidering the Balance in Administration.

    ERIC Educational Resources Information Center

    Lancaster, James M.; Cooper, Diane L.

    1998-01-01

    States that student affairs administrators must choose wisely between increasing reliance on legal minimalism and a more reflective judgment model that can evolve toward a model of unified practice balancing policy and law with developmentally appropriate practices. Offers recommendations concerning the future of student affairs. (Author/MKA)

  20. FORMED: Bringing Formal Methods to the Engineering Desktop

    DTIC Science & Technology

    2016-02-01

    integrates formal verification into software design and development by precisely defining semantics for a restricted subset of the Unified Modeling...input-output contract satisfaction and absence of null pointer dereferences. 15. SUBJECT TERMS Formal Methods, Software Verification , Model-Based...Domain specific languages (DSLs) drive both implementation and formal verification

  1. Aerospace System Unified Life Cycle Engineering Producibility Measurement Issues

    DTIC Science & Technology

    1989-05-01

    Control .................................................................. 11-9 5 . C o st...in the development process; these computer -aided models offer clarity approaching that of a prototype model. Once a part geometry is represented...of part geometry , allowing manufacturability evaluation and possibly other computer -integrated manufacturing (CIM) tasks. (Other papers that discuss

  2. Theoretical Convergence in Assessment of Cognition

    ERIC Educational Resources Information Center

    Bowden, Stephen C.

    2013-01-01

    In surveying the literature on assessment of cognitive abilities in adults and children, it is easy to assume that the proliferation of test batteries and terminology reflects a poverty of unifying models. However, the lack of recognition accorded good models of cognitive abilities may reflect inattention to theoretical development and injudicious…

  3. Building Dynamic Conceptual Physics Understanding

    ERIC Educational Resources Information Center

    Trout, Charlotte; Sinex, Scott A.; Ragan, Susan

    2011-01-01

    Models are essential to the learning and doing of science, and systems thinking is key to appreciating many environmental issues. The National Science Education Standards include models and systems in their unifying concepts and processes standard, while the AAAS Benchmarks include them in their common themes chapter. Hyerle and Marzano argue for…

  4. Potential of DCT/SCDT in Addressing Two Elusive Themes of Mental Health Counseling.

    ERIC Educational Resources Information Center

    Borders, L. DiAnne

    1994-01-01

    Responds to previous article by Rigazio-DiGilio on Developmental Counseling and Therapy and Systemic Cognitive-Developmental Therapy as two integrative models that unify individual, family, and network treatment within coconstructive-developmental framework. Considers extent to which model breaks impasse in integrating development into counseling…

  5. Experiments with the Combat CAS: Unifying Net-Enabled Teams

    DTIC Science & Technology

    2009-06-01

    1998. “ Network Centric Warfare: Its Origin and Future.” Proceedings. Volume 124/1/1, 139. Annapolis, MD: U.S. Naval Institute. Chomsky , Noam ...linguistic models, see Chomsky 1962). Discourse models make explicit the structure not of sentences but of situations as we perceive or imagine them

  6. A View of the Combat CAS: Unifying Net-Enabled Teams

    DTIC Science & Technology

    2008-01-01

    Centric Warfare: Its Origin and Future. Proceedings. Volume 124/1/1, 139. Annapolis, MD: U.S. Naval Institute. Chomsky , Noam . 1962. Syntactic Structures...representations and discourse models (For linguistic mod- els, see Chomsky 1962). Discourse models make explicit the struc- ture not of sentences but of

  7. Bayesian Estimation of Multi-Unidimensional Graded Response IRT Models

    ERIC Educational Resources Information Center

    Kuo, Tzu-Chun

    2015-01-01

    Item response theory (IRT) has gained an increasing popularity in large-scale educational and psychological testing situations because of its theoretical advantages over classical test theory. Unidimensional graded response models (GRMs) are useful when polytomous response items are designed to measure a unified latent trait. They are limited in…

  8. A Model for Conducting and Assessing Interdisciplinary Undergraduate Dissertations

    ERIC Educational Resources Information Center

    Engström, Henrik

    2015-01-01

    This paper presents an effort to create a unified model for conducting and assessing undergraduate dissertations, shared by all disciplines involved in computer game development at a Swedish university. Computer game development includes technology-oriented disciplines as well as disciplines with aesthetical traditions. The challenge has been to…

  9. A Unified Framework for Monetary Theory and Policy Analysis.

    ERIC Educational Resources Information Center

    Lagos, Ricardo; Wright, Randall

    2005-01-01

    Search-theoretic models of monetary exchange are based on explicit descriptions of the frictions that make money essential. However, tractable versions of these models typically make strong assumptions that render them ill suited for monetary policy analysis. We propose a new framework, based on explicit micro foundations, within which macro…

  10. Performance modeling codes for the QuakeSim problem solving environment

    NASA Technical Reports Server (NTRS)

    Parker, J. W.; Donnellan, A.; Lyzenga, G.; Rundle, J.; Tullis, T.

    2003-01-01

    The QuakeSim Problem Solving Environment uses a web-services approach to unify and deploy diverse remote data sources and processing services within a browser environment. Here we focus on the high-performance crustal modeling applications that will be included in this set of remote but interoperable applications.

  11. Social Media Usage: Examination of Influencers and Effects

    ERIC Educational Resources Information Center

    Brooks, Stoney L.

    2013-01-01

    This dissertation is concerned with investigating topics surrounding the phenomenon of social media usage. Essay One draws from the technology acceptance literature by utilizing concepts from the Technology Acceptance Model (TAM), the Unified Theory of Acceptance and Use of Technology (UTAUT), and the model of hedonic technology acceptance. The…

  12. Designing Corporate Databases to Support Technology Innovation

    ERIC Educational Resources Information Center

    Gultz, Michael Jarett

    2012-01-01

    Based on a review of the existing literature on database design, this study proposed a unified database model to support corporate technology innovation. This study assessed potential support for the model based on the opinions of 200 technology industry executives, including Chief Information Officers, Chief Knowledge Officers and Chief Learning…

  13. A Unified Cropland Layer at 250-m for global agriculture monitoring

    USGS Publications Warehouse

    Waldner, François; Fritz, Steffen; Di Gregorio, Antonio; Plotnikov, Dmitry; Bartalev, Sergey; Kussul, Nataliia; Gong, Peng; Thenkabail, Prasad S.; Hazeu, Gerard; Klein, Igor; Löw, Fabian; Miettinen, Jukka; Dadhwal, Vinay Kumar; Lamarche, Céline; Bontemps, Sophie; Defourny, Pierre

    2016-01-01

    Accurate and timely information on the global cropland extent is critical for food security monitoring, water management and earth system modeling. Principally, it allows for analyzing satellite image time-series to assess the crop conditions and permits isolation of the agricultural component to focus on food security and impacts of various climatic scenarios. However, despite its critical importance, accurate information on the spatial extent, cropland mapping with remote sensing imagery remains a major challenge. Following an exhaustive identification and collection of existing land cover maps, a multi-criteria analysis was designed at the country level to evaluate the fitness of a cropland map with regards to four dimensions: its timeliness, its legend, its resolution adequacy and its confidence level. As a result, a Unified Cropland Layer that combines the fittest products into a 250 m global cropland map was assembled. With an evaluated accuracy ranging from 82% to 95%, the Unified Cropland Layer successfully improved the accuracy compared to single global products.

  14. Constitutive modeling for isotropic materials (HOST)

    NASA Technical Reports Server (NTRS)

    Lindholm, U. S.; Chan, K. S.; Bodner, S. R.; Weber, R. M.; Walker, K. P.; Cassenti, B. N.

    1985-01-01

    This report presents the results of the second year of work on a problem which is part of the NASA HOST Program. Its goals are: (1) to develop and validate unified constitutive models for isotropic materials, and (2) to demonstrate their usefulness for structural analyses of hot section components of gas turbine engines. The unified models selected for development and evaluation are that of Bodner-Partom and Walker. For model evaluation purposes, a large constitutive data base is generated for a B1900 + Hf alloy by performing uniaxial tensile, creep, cyclic, stress relation, and thermomechanical fatigue (TMF) tests as well as biaxial (tension/torsion) tests under proportional and nonproportional loading over a wide range of strain rates and temperatures. Systematic approaches for evaluating material constants from a small subset of the data base are developed. Correlations of the uniaxial and biaxial tests data with the theories of Bodner-Partom and Walker are performed to establish the accuracy, range of applicability, and integability of the models. Both models are implemented in the MARC finite element computer code and used for TMF analyses. Benchmark notch round experiments are conducted and the results compared with finite-element analyses using the MARC code and the Walker model.

  15. Fully Associative, Nonisothermal, Potential-Based Unified Viscoplastic Model for Titanium-Based Matrices

    NASA Technical Reports Server (NTRS)

    2005-01-01

    A number of titanium matrix composite (TMC) systems are currently being investigated for high-temperature air frame and propulsion system applications. As a result, numerous computational methodologies for predicting both deformation and life for this class of materials are under development. An integral part of these methodologies is an accurate and computationally efficient constitutive model for the metallic matrix constituent. Furthermore, because these systems are designed to operate at elevated temperatures, the required constitutive models must account for both time-dependent and time-independent deformations. To accomplish this, the NASA Lewis Research Center is employing a recently developed, complete, potential-based framework. This framework, which utilizes internal state variables, was put forth for the derivation of reversible and irreversible constitutive equations. The framework, and consequently the resulting constitutive model, is termed complete because the existence of the total (integrated) form of the Gibbs complementary free energy and complementary dissipation potentials are assumed a priori. The specific forms selected here for both the Gibbs and complementary dissipation potentials result in a fully associative, multiaxial, nonisothermal, unified viscoplastic model with nonlinear kinematic hardening. This model constitutes one of many models in the Generalized Viscoplasticity with Potential Structure (GVIPS) class of inelastic constitutive equations.

  16. Consistency of Cluster Analysis for Cognitive Diagnosis: The Reduced Reparameterized Unified Model and the General Diagnostic Model.

    PubMed

    Chiu, Chia-Yi; Köhn, Hans-Friedrich

    2016-09-01

    The asymptotic classification theory of cognitive diagnosis (ACTCD) provided the theoretical foundation for using clustering methods that do not rely on a parametric statistical model for assigning examinees to proficiency classes. Like general diagnostic classification models, clustering methods can be useful in situations where the true diagnostic classification model (DCM) underlying the data is unknown and possibly misspecified, or the items of a test conform to a mix of multiple DCMs. Clustering methods can also be an option when fitting advanced and complex DCMs encounters computational difficulties. These can range from the use of excessive CPU times to plain computational infeasibility. However, the propositions of the ACTCD have only been proven for the Deterministic Input Noisy Output "AND" gate (DINA) model and the Deterministic Input Noisy Output "OR" gate (DINO) model. For other DCMs, there does not exist a theoretical justification to use clustering for assigning examinees to proficiency classes. But if clustering is to be used legitimately, then the ACTCD must cover a larger number of DCMs than just the DINA model and the DINO model. Thus, the purpose of this article is to prove the theoretical propositions of the ACTCD for two other important DCMs, the Reduced Reparameterized Unified Model and the General Diagnostic Model.

  17. Control of magnetic bearing systems via the Chebyshev polynomial-based unified model (CPBUM) neural network.

    PubMed

    Jeng, J T; Lee, T T

    2000-01-01

    A Chebyshev polynomial-based unified model (CPBUM) neural network is introduced and applied to control a magnetic bearing systems. First, we show that the CPBUM neural network not only has the same capability of universal approximator, but also has faster learning speed than conventional feedforward/recurrent neural network. It turns out that the CPBUM neural network is more suitable in the design of controller than the conventional feedforward/recurrent neural network. Second, we propose the inverse system method, based on the CPBUM neural networks, to control a magnetic bearing system. The proposed controller has two structures; namely, off-line and on-line learning structures. We derive a new learning algorithm for each proposed structure. The experimental results show that the proposed neural network architecture provides a greater flexibility and better performance in controlling magnetic bearing systems.

  18. An Unified Multiscale Framework for Planar, Surface, and Curve Skeletonization.

    PubMed

    Jalba, Andrei C; Sobiecki, Andre; Telea, Alexandru C

    2016-01-01

    Computing skeletons of 2D shapes, and medial surface and curve skeletons of 3D shapes, is a challenging task. In particular, there is no unified framework that detects all types of skeletons using a single model, and also produces a multiscale representation which allows to progressively simplify, or regularize, all skeleton types. In this paper, we present such a framework. We model skeleton detection and regularization by a conservative mass transport process from a shape's boundary to its surface skeleton, next to its curve skeleton, and finally to the shape center. The resulting density field can be thresholded to obtain a multiscale representation of progressively simplified surface, or curve, skeletons. We detail a numerical implementation of our framework which is demonstrably stable and has high computational efficiency. We demonstrate our framework on several complex 2D and 3D shapes.

  19. Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings

    PubMed Central

    García-López, Pablo; García-Marín, Virginia; Freire, Miguel

    2010-01-01

    Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. Here, we present original results obtained from high-quality images of Cajal's histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained using extended focus imaging, three-dimensional reconstruction, and rendering. Based on the data available in the literature regarding the formation of dendritic spines during development and our results, we propose a unifying model for dendritic spine development. PMID:21584262

  20. Noncommutative GUTs, Standard Model and C, P, T

    NASA Astrophysics Data System (ADS)

    Aschieri, P.; Jurčo, B.; Schupp, P.; Wess, J.

    2003-02-01

    Noncommutative Yang-Mills theories are sensitive to the choice of the representation that enters in the gauge kinetic term. We constrain this ambiguity by considering grand unified theories. We find that at first order in the noncommutativity parameter θ, SU(5) is not truly a unified theory, while SO(10) has a unique noncommutative generalization. In view of these results we discuss the noncommutative SM theory that is compatible with SO(10) GUT and find that there are no modifications to the SM gauge kinetic term at lowest order in θ. We study in detail the reality, Hermiticity and C, P, T properties of the Seiberg-Witten map and of the resulting effective actions expanded in ordinary fields. We find that in models of GUTs (or compatible with GUTs) right-handed fermions and left-handed ones appear with opposite Seiberg-Witten map.

  1. Integrating HL7 RIM and ontology for unified knowledge and data representation in clinical decision support systems.

    PubMed

    Zhang, Yi-Fan; Tian, Yu; Zhou, Tian-Shu; Araki, Kenji; Li, Jing-Song

    2016-01-01

    The broad adoption of clinical decision support systems within clinical practice has been hampered mainly by the difficulty in expressing domain knowledge and patient data in a unified formalism. This paper presents a semantic-based approach to the unified representation of healthcare domain knowledge and patient data for practical clinical decision making applications. A four-phase knowledge engineering cycle is implemented to develop a semantic healthcare knowledge base based on an HL7 reference information model, including an ontology to model domain knowledge and patient data and an expression repository to encode clinical decision making rules and queries. A semantic clinical decision support system is designed to provide patient-specific healthcare recommendations based on the knowledge base and patient data. The proposed solution is evaluated in the case study of type 2 diabetes mellitus inpatient management. The knowledge base is successfully instantiated with relevant domain knowledge and testing patient data. Ontology-level evaluation confirms model validity. Application-level evaluation of diagnostic accuracy reaches a sensitivity of 97.5%, a specificity of 100%, and a precision of 98%; an acceptance rate of 97.3% is given by domain experts for the recommended care plan orders. The proposed solution has been successfully validated in the case study as providing clinical decision support at a high accuracy and acceptance rate. The evaluation results demonstrate the technical feasibility and application prospect of our approach. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  2. A unified and efficient framework for court-net sports video analysis using 3D camera modeling

    NASA Astrophysics Data System (ADS)

    Han, Jungong; de With, Peter H. N.

    2007-01-01

    The extensive amount of video data stored on available media (hard and optical disks) necessitates video content analysis, which is a cornerstone for different user-friendly applications, such as, smart video retrieval and intelligent video summarization. This paper aims at finding a unified and efficient framework for court-net sports video analysis. We concentrate on techniques that are generally applicable for more than one sports type to come to a unified approach. To this end, our framework employs the concept of multi-level analysis, where a novel 3-D camera modeling is utilized to bridge the gap between the object-level and the scene-level analysis. The new 3-D camera modeling is based on collecting features points from two planes, which are perpendicular to each other, so that a true 3-D reference is obtained. Another important contribution is a new tracking algorithm for the objects (i.e. players). The algorithm can track up to four players simultaneously. The complete system contributes to summarization by various forms of information, of which the most important are the moving trajectory and real-speed of each player, as well as 3-D height information of objects and the semantic event segments in a game. We illustrate the performance of the proposed system by evaluating it for a variety of court-net sports videos containing badminton, tennis and volleyball, and we show that the feature detection performance is above 92% and events detection about 90%.

  3. Wide dynamic logarithmic InGaAs sensor suitable for eye-safe active imaging

    NASA Astrophysics Data System (ADS)

    Ni, Yang; Bouvier, Christian; Arion, Bogdan; Noguier, Vincent

    2016-05-01

    In this paper, we present a simple method to analyze the injection efficiency of the photodiode interface circuit under fast shuttering conditions for active Imaging applications. This simple model has been inspired from the companion model for reactive elements largely used in CAD. In this paper, we demonstrate that traditional CTIA photodiode interface is not adequate for active imaging where fast and precise shuttering operation is necessary. Afterwards we present a direct amplification based photodiode interface which can provide an accurate and fast shuttering operation on photodiode. These considerations have been used in NIT's newly developed ROIC and corresponding SWIR sensors both in VGA 15um pitch (NSC1201) and also in QVGA 25um pitch (NSC1401).

  4. Compositional control of continuously graded anode functional layer

    NASA Astrophysics Data System (ADS)

    McCoppin, J.; Barney, I.; Mukhopadhyay, S.; Miller, R.; Reitz, T.; Young, D.

    2012-10-01

    In this work, solid oxide fuel cells (SOFC's) are fabricated with linear-compositionally graded anode functional layers (CGAFL) using a computer-controlled compound aerosol deposition (CCAD) system. Cells with different CGAFL thicknesses (30 um and 50 um) are prepared with a continuous compositionally graded interface deposited between the electrolyte and anode support current collecting regions. The compositional profile was characterized using energy dispersive X-ray spectroscopic mapping. An analytical model of the compound aerosol deposition was developed. The model predicted compositional profiles for both samples that closely matched the measured profiles, suggesting that aerosol-based deposition methods are capable of creating functional gradation on length scales suitable for solid oxide fuel cell structures. The electrochemical performances of the two cells are analyzed using electrochemical impedance spectroscopy (EIS).

  5. High-speed 1.3 -1.55 um InGaAs/InP PIN photodetector for microwave photonics

    NASA Astrophysics Data System (ADS)

    Kozyreva, O. A.; Solov'ev, Y. V.; Polukhin, I. S.; Mikhailov, A. K.; Mikhailovskiy, G. A.; Odnoblyudov, M. A.; Gareev, E. Z.; Kolodeznyi, E. S.; Novikov, I. I.; Karachinsky, L. Ya; Egorov, A. Yu; Bougrov, V. E.

    2017-11-01

    We have fabricated the 1.3-1.55 um PIN photodetector based on InGaAs/InP heterostructure. Measurement results of optical and electrical characteristics of PIN photodetector chip were the following: photoconductivity at 1550 nm was 0.65 A/W and internal capacitance was 0.025 pF. Microwave model of photodetector was developed and verified by measurements of scattering matrix. The implementation of broadband (up to 20 GHz) hybrid integrated matching and biasing circuit for high-speed photodetector is presented.

  6. Modeling Thermal Inactivation of Bacillus Spores

    DTIC Science & Technology

    2009-03-01

    Ungers, G. “The Negative Control Mecha- nism for E . Coli DNA Replication,” Proceedings of the National Academy of Sci- ences of the USA, 63: 1410-1417...damage by: d [DNA] dt = − k1 [DNA]− k2 [H2O] [DNA] where [DNA] =information content of DNA k1 =rate coefficient associated with [DNA] breakdown during...ax im um a va ila bl e w at er p er u ni t v ol um e Core Cortex Absorbed water Bound water Total water Figure 3.2: Initial Distribution of

  7. Ultramicronized palmitoylethanolamide (PEA-um(®)) in the treatment of idiopathic pulmonary fibrosis.

    PubMed

    Di Paola, Rosanna; Impellizzeri, Daniela; Fusco, Roberta; Cordaro, Marika; Siracusa, Rosalba; Crupi, Rosalia; Esposito, Emanuela; Cuzzocrea, Salvatore

    2016-09-01

    Pulmonary fibrosis is a chronic condition characterized by progressive scarring of lung parenchyma. The aim of this study was to examine the effects of an ultramicronized preparation of palmitoylethanolamide (PEA-um(®)), an endogenous fatty acid amide, in mice subjected to idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis was induced in male mice by a single intratracheal administration of saline with bleomycin sulphate (1mg/kg body weight) in a volume of 100μL. PEA-um(®) was injected intraperitoneally at 1, 3 or 10mg/kg 1h after bleomycin instillation and daily thereafter. Animals were sacrificed after 7 and 21days by pentobarbitone overdose. One cohort of mice was sacrificed after seven days of bleomycin administration, followed by bronchoalveloar lavage and determination of myeloperoxidase activity, lung edema and histopathology features. In the 21-day cohort, mortality was assessed daily, and surviving mice were sacrificed followed by the above analyses together with immunohistochemical localization of CD8, tumor necrosis factor-α, CD4, interleukin-1β, transforming growth factor-β, inducible nitric oxide synthase and basic fibroblast growth factor. Compared to bleomycin-treated mice, animals that received also PEA-um(®) (3 or 10mg/kg) had significantly decreased weight loss, mortality, inflammation, lung damage at the histological level, and lung fibrosis at 7 and 21days. PEA-um(®) (1mg/kg) did not significantly inhibit the inflammation response and lung fibrosis. This study demonstrates that PEA-um(®) (3 and 10mg/kg) reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Health and innovation: economic dynamics and Welfare State in Brazil.

    PubMed

    Gadelha, Carlos Augusto Grabois; Braga, Patrícia Seixas da Costa

    2016-11-03

    The effective enforcement of the access to healthcare as fundamental right requires an important theoretical and political effort at linking the often contradictory economic and social dimensions of development. This study suggests the need for a systemic view of policies related to the industrial base and innovation in health and the construction of the Brazilian Unified National Health System (SUS). The authors investigate the relations between health, innovation, and development, seeking to show and update the political, economic, and social determinants of the recent Brazilian experience with the Health Economic-Industrial Complex (HEIC). They discuss how the agenda for innovation and domestic industrial production in health gained a central place in the project for construction of the SUS. The article thus seeks to link inherent issues from the agenda for development, production, and innovation to social policy in healthcare, as observed in recent years, and based on this analysis, points to political and conceptual challenges for implementing the SUS, especially as regards strengthening its technological and industrial base. As a byproduct, the article develops an analytical and factual focus on the consolidation of the HEIC in Brazil, both as a dynamic vector of industrial development, generating investment, income, employment, and innovations, and as a decisive element for reducing vulnerability and structural dependence in health. The authors aim to show that strengthening the SUS and orienting it to social needs is an essential part of building a social Welfare State in Brazil. Resumo: A efetivação da saúde como um direito fundamental exige importante esforço, teórico e político, de articulação das dimensões econômicas e sociais, por vezes contraditórias, do desenvolvimento. Este trabalho indica a necessidade de um olhar sistêmico das políticas relacionadas à base produtiva e de inovação em saúde e à construção do Sistema Único de Saúde (SUS). Investiga as relações entre saúde, inovação e desenvolvimento, buscando mostrar e atualizar os determinantes políticos, econômicos e sociais da experiência brasileira recente relacionada ao Complexo Econômico-Industrial da Saúde (CEIS). Mostra como a agenda da inovação e da produção nacional em saúde ganhou centralidade no projeto de construção do SUS. O artigo procura, assim, articular questões inerentes à agenda do desenvolvimento, da produção e da inovação com a política social em saúde, tal como observado nos últimos anos e, valendo-se de sua análise, aponta desafios políticos e conceituais para a efetivação do SUS, em especial no que se refere ao fortalecimento de sua base tecnológica e produtiva. Como desdobramento, desenvolve um enfoque analítico e factual que relaciona a consolidação do CEIS no Brasil tanto como um vetor dinâmico do desenvolvimento industrial, gerando investimento, renda, emprego e inovações, quanto como elemento decisivo para a redução da vulnerabilidade e da dependência estrutural em saúde. Procura mostrar que seu fortalecimento e direcionamento para as necessidades sociais é parte essencial da construção de um Estado de Bem-Estar Social no Brasi.

  9. Open system models of isotopic evolution in Earth's silicate reservoirs: Implications for crustal growth and mantle heterogeneity

    NASA Astrophysics Data System (ADS)

    Kumari, Seema; Paul, Debajyoti; Stracke, Andreas

    2016-12-01

    An open system evolutionary model of the Earth, comprising continental crust (CC), upper and lower mantle (UM, LM), and an additional isolated reservoir (IR) has been developed to study the isotopic evolution of the silicate Earth. The model is solved numerically at 1 Myr time steps over 4.55 Gyr of Earth history to reproduce both the present-day concentrations and isotope ratios of key radioactive decay systems (Rb-Sr, Sm-Nd, and U-Th-Pb) in these terrestrial reservoirs. Various crustal growth scenarios - continuous versus episodic and early versus late crustal growth - and their effect on the evolution of Sr-Nd-Pb isotope systematics in the silicate reservoirs have been evaluated. Modeling results where the present-day UM is ∼60% of the total mantle mass and a lower mantle that is non-primitive reproduce the estimated geochemical composition and isotope ratios in Earth's silicate reservoirs. The isotopic evolution of the silicate Earth is strongly affected by the mode of crustal growth; only an exponential crustal growth pattern with crustal growth since the early Archean satisfactorily explains the chemical and isotopic evolution of the crust-mantle system and accounts for the so-called Pb paradoxes. Assuming that the OIB source is located in the deeper mantle, our model could, however, not reproduce its target ɛNd of +4.6 for the UM, which has been estimated from the average isotope ratios of 32 individual ocean island localities. Hence, either mantle plumes sample the LM in a non-representative way, or the simplified model set-up does not capture the full complexity of Earth's lower mantle (Nd isotope) evolution. Compared to the results obtained for a 4.55 Ga Earth, a model assuming a protracted U-Pb evolution of silicate Earth by ca. 100 Myr reproduces a slightly better fit for the Pb isotope ratios in Earth's silicate reservoirs. One notable feature of successful models is the early depletion of incompatible elements (as well as rapid decrease in Th/U) in the UM within the initial 500 Myr, as a result of early formation of CC, which supports other evidence in favor of the presence of Hadean continental crust. Therefore, a chondritic Th/U ratio (4 ± 0.2) in the UM until 2 Gyr appears rather unlikely. We find that the κ conundrum - the observation that measured Th/U ratios and those deduced from 208Pb-206Pb isotope systematics differ - is a natural outcome of an open system evolution in which preferential recycling of U for the past 2 Gyr has played a dominant role. Overall, our simulations strongly favor exponential crustal growth, starting in the early Hadean, the transient preservation of compositionally distinct mantle reservoirs over billion year time periods, and a generally less incompatible element depleted, but non-primitive composition of the lower mantle.

  10. IR spectral properties of dust and ice at the Mars south polar cap

    NASA Astrophysics Data System (ADS)

    Titus, T. N.; Kieffer, H. H.

    2001-11-01

    Removal of atmospheric dust effects is required to derive surface IR spectral emissivity. Commonly, the atmospheric-surface separation is based on radiative transfer (RT) spectral inversion methods using nadir-pointing observations. This methodology depends on a priori knowledge of the spectral shape of each atmospheric aerosol (e.g. dust or water ice) and a large thermal contrast between the surface and atmosphere. RT methods fail over the polar caps due to low thermal contrast between the atmosphere and the surface. We have used multi-angle Emission Phase Function (EPF) observations to estimate the opacity spectrum of dust over the springtime south polar cap and the underlying surface radiance, and thus, the surface emissivity. We include a few EPFs from Hellas Basin as a basis for comparisons between the spectral shape of polar and non-polar dust. Surface spectral emissivities over the seasonal cap are compared to CO2 models. Our results show that the spectral shape of the polar dust opacity is not constant, but is a two-parameter family that can be characterized by the 9 um and 20 um opacities. The 9 um opacity varies from 0.15 to 0.45 and characterizes the overall atmospheric conditions. The 9 um to 20 um opacity ratio varies from 2.0 to 5.1, suggesting changes in dust size distribution over the polar caps. Derived surface temperatures from the EPFs confirm that the slightly elevated temperatures (relative to CO2 frost temperature) observed in ``cryptic'' regions are a surface effect, not atmospheric. Comparison of broad-band reflectivity and surface emissivities to model spectra suggest the bright regions (e.g. perennial cap, Mountains of Mitchell) have higher albedos due to a thin surface layer of fine-grain CO2 (perhaps either frost or fractured ice) with an underlying layer of either coarse grain or slab CO2 ice.

  11. "All in the Family" in Context: A Unified Model of Media Studies Applied to Television Criticism.

    ERIC Educational Resources Information Center

    Timberg, Bernard

    Proposing the use of a single comprehensive communications model, the Circles of Context Model, for all forms of communication, this paper shows how the model can be used to identify different kinds of criticism of the television comedy series "All in the Family" and the ways in which that criticism shifted during the show's nine-year…

  12. General slip regime permeability model for gas flow through porous media

    NASA Astrophysics Data System (ADS)

    Zhou, Bo; Jiang, Peixue; Xu, Ruina; Ouyang, Xiaolong

    2016-07-01

    A theoretical effective gas permeability model was developed for rarefied gas flow in porous media, which holds over the entire slip regime with the permeability derived as a function of the Knudsen number. This general slip regime model (GSR model) is derived from the pore-scale Navier-Stokes equations subject to the first-order wall slip boundary condition using the volume-averaging method. The local closure problem for the volume-averaged equations is studied analytically and numerically using a periodic sphere array geometry. The GSR model includes a rational fraction function of the Knudsen number which leads to a limit effective permeability as the Knudsen number increases. The mechanism for this behavior is the viscous fluid inner friction caused by converging-diverging flow channels in porous media. A linearization of the GSR model leads to the Klinkenberg equation for slightly rarefied gas flows. Finite element simulations show that the Klinkenberg model overestimates the effective permeability by as much as 33% when a flow approaches the transition regime. The GSR model reduces to the unified permeability model [F. Civan, "Effective correlation of apparent gas permeability in tight porous media," Transp. Porous Media 82, 375 (2010)] for the flow in the slip regime and clarifies the physical significance of the empirical parameter b in the unified model.

  13. Attenuation of midinfrared free electron laser energy with eyewear

    NASA Astrophysics Data System (ADS)

    Joos, Karen M.; Gabella, William

    2005-04-01

    Purpose: To determine the attenuation of free electron laser (FEL) energy at several wavelengths through microscope objective and eyeglass lenses. Materials and Methods: The FEL at wavelengths of 2.3 um, 2.5 um, 3.0 um, 3.5 um, 4.0 um, 4.5 um, 5.0 um, 6.45 um, 7.0 um, 7.5 um, and 8.0 um was telescoped using a 500 mm nominal focal length lens and a 200 mm focal length lens. The beam had a final spot of about 3 mm and was passed through a 3 mm aperture and onto the 8 mm active area of a J9LP Molectron detector. The eyeglass sample was placed 3 cm in front of the detector. Energy readings were averaged over multiple pulses. Results: Attenuation varied greatly with wavelength and sample from a low attenuation of 0.46 dB, 90% transmission, for short wavelengths through common glass to greater than 60 dB attenuation (transmission at the detector noise level) for IR safe glass by Aura, Inc. Conclusion: Only the designated laser safety goggles effectively attenuate free electron laser energy at 2.3 um and 2.5 um. A microscope objective lens, polycarbonate, and silica glass eyewear is capable of effectively attenuating FEL energy at wavelengths greater than 4.5 um, but the polycarbonate lenses demonstrated material damage.

  14. A new general circulation model of Jupiter's atmosphere based on the UKMO Unified Model: Three-dimensional evolution of isolated vortices and zonal jets in mid-latitudes

    NASA Astrophysics Data System (ADS)

    Yamazaki, Y. H.; Skeet, D. R.; Read, P. L.

    2004-04-01

    We have been developing a new three-dimensional general circulation model for the stratosphere and troposphere of Jupiter based on the dynamical core of a portable version of the Unified Model of the UK Meteorological Office. Being one of the leading terrestrial GCMs, employed for operational weather forecasting and climate research, the Unified Model has been thoroughly tested and performance tuned for both vector and parallel computers. It is formulated as a generalized form of the standard primitive equations to handle a thick atmosphere, using a scaled pressure as the vertical coordinate. It is able to accurately simulate the dynamics of a three-dimensional fully compressible atmosphere on the whole or a part of a spherical shell at high spatial resolution in all three directions. Using the current version of the GCM, we examine the characteristics of the Jovian winds in idealized configurations based on the observed vertical structure of temperature. Our initial focus is on the evolution of isolated eddies in the mid-latitudes. Following a brief theoretical investigation of the vertical structure of the atmosphere, limited-area cyclic channel domains are used to numerically investigate the nonlinear evolution of the mid-latitude winds. First, the evolution of deep and shallow cyclones and anticyclones are tested in the atmosphere at rest to identify a preferred horizontal and vertical structure of the vortices. Then, the dependency of the migration characteristics of the vortices are investigated against modelling parameters to find that it is most sensitive to the horizontal diffusion. We also examine the hydrodynamical stability of observed subtropical jets in both northern and southern hemispheres in the three-dimensional nonlinear model as initial value problems. In both cases, it was found that the prominent jets are unstable at various scales and that vorteces of various sizes are generated including those comparable to the White Ovals and the Great Red Spot.

  15. ViDI: Virtual Diagnostics Interface. Volume 2; Unified File Format and Web Services as Applied to Seamless Data Transfer

    NASA Technical Reports Server (NTRS)

    Fleming, Gary A. (Technical Monitor); Schwartz, Richard J.

    2004-01-01

    The desire to revolutionize the aircraft design cycle from its currently lethargic pace to a fast turn-around operation enabling the optimization of non-traditional configurations is a critical challenge facing the aeronautics industry. In response, a large scale effort is underway to not only advance the state of the art in wind tunnel testing, computational modeling, and information technology, but to unify these often disparate elements into a cohesive design resource. This paper will address Seamless Data Transfer, the critical central nervous system that will enable a wide variety of varied components to work together.

  16. Cosmological consequences of grand unified theories on density fluctuations

    NASA Astrophysics Data System (ADS)

    Lindley, D.

    1981-05-01

    Recent investigations into the cosmological consequences of grand unified theories (GUTs) of elementary particles have shown that the observed matter-antimatter asymmetry of the Universe can be explained without recourse to the hypothesis of specific initial conditions. It is shown here that the origin of inhomogeneities in the matter distribution, which are thought to be responsible for the later formation of galaxies, cannot be explained by a simple addition of density fluctuations to the standard model. The appearance of these fluctuations, after the epoch when baryon number is fixed, is almost purely adiabatic, any departure from adiabaticity falling off in inverse proportion to the mass of the perturbation.

  17. 3 CFR - Unified Command Plan 2011

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Unified Command Plan 2011 Presidential Documents Other Presidential Documents Memorandum of April 6, 2011 Unified Command Plan 2011 Memorandum for the... implementation of the revised Unified Command Plan. Consistent with title 10, United States Code, section 161(b...

  18. Micro pore arrays in free standing cyclic olefin copolymer membranes: fabrication and surface functionalization strategies for in-vitro barrier tissue models

    NASA Astrophysics Data System (ADS)

    Gel, M.; Kandasamy, S.; Cartledge, K.; Be, C. L.; Haylock, D.

    2013-12-01

    In recent years there has been growing interest in micro engineered in-vitro models of tissues and organs. These models are designed to mimic the in-vivo like physiological conditions with a goal to study human physiology in an organ-specific context or to develop in-vitro disease models. One of the challenges in the development of these models is the formation of barrier tissues in which the permeability is controlled locally by the tissues cultured at the interface. In-vitro models of barrier tissues are typically created by generating a monolayer of cells grown on thin porous membranes. This paper reports a robust preparation method for free standing porous cyclic olefin copolymer (COC) membranes. We also demonstrate that gelatin coated membranes facilitate formation of highly confluent monolayer of HUVECs. Membranes with thickness in the range of 2-3 um incorporating micro pores with diameter approximately 20 um were fabricated and integrated with microfluidic channels. The performance of the device was demonstrated with a model system mimicking the endothelial barrier in bone marrow sinusoids.

  19. 76 FR 76046 - Interim Final Determination To Defer Sanctions, San Joaquin Valley Unified Air Pollution Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Determination To Defer Sanctions, San Joaquin Valley Unified Air Pollution Control District AGENCY... Valley Unified Air Pollution Control District (SJVUAPCD or District) portion of the California State...), we finalized a limited approval and limited disapproval of San Joaquin Valley Unified Air Pollution...

  20. 76 FR 41745 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... approval and limited disapproval of revisions to the San Joaquin Valley Unified Air Pollution Control... Valley Unified Air Pollution Control District (SJVUAPCD) Rule 4682, Polystyrene, Polyethylene, and...

  1. 76 FR 68103 - Revisions to the California State Implementation Plan, San Joaquin Valley Unified Air Pollution...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... the California State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District... revisions to the San Joaquin Valley Unified Air Pollution Control District (SJVUAPCD) portion of the... State Implementation Plan, San Joaquin Valley Unified Air Pollution Control District Rule 4692...

  2. A grand unified model for liganded gold clusters

    NASA Astrophysics Data System (ADS)

    Xu, Wen Wu; Zhu, Beien; Zeng, Xiao Cheng; Gao, Yi

    2016-12-01

    A grand unified model (GUM) is developed to achieve fundamental understanding of rich structures of all 71 liganded gold clusters reported to date. Inspired by the quark model by which composite particles (for example, protons and neutrons) are formed by combining three quarks (or flavours), here gold atoms are assigned three `flavours' (namely, bottom, middle and top) to represent three possible valence states. The `composite particles' in GUM are categorized into two groups: variants of triangular elementary block Au3(2e) and tetrahedral elementary block Au4(2e), all satisfying the duet rule (2e) of the valence shell, akin to the octet rule in general chemistry. The elementary blocks, when packed together, form the cores of liganded gold clusters. With the GUM, structures of 71 liganded gold clusters and their growth mechanism can be deciphered altogether. Although GUM is a predictive heuristic and may not be necessarily reflective of the actual electronic structure, several highly stable liganded gold clusters are predicted, thereby offering GUM-guided synthesis of liganded gold clusters by design.

  3. A New Unified Analysis of Estimate Errors by Model-Matching Phase-Estimation Methods for Sensorless Drive of Permanent-Magnet Synchronous Motors and New Trajectory-Oriented Vector Control, Part I

    NASA Astrophysics Data System (ADS)

    Shinnaka, Shinji; Sano, Kousuke

    This paper presents a new unified analysis of estimate errors by model-matching phase-estimation methods such as rotor-flux state-observers, back EMF state-observers, and back EMF disturbance-observers, for sensorless drive of permanent-magnet synchronous motors. Analytical solutions about estimate errors, whose validity is confirmed by numerical experiments, are rich in universality and applicability. As an example of universality and applicability, a new trajectory-oriented vector control method is proposed, which can realize directly quasi-optimal strategy minimizing total losses with no additional computational loads by simply orienting one of vector-control coordinates to the associated quasi-optimal trajectory. The coordinate orientation rule, which is analytically derived, is surprisingly simple. Consequently the trajectory-oriented vector control method can be applied to a number of conventional vector control systems using one of the model-matching phase-estimation methods.

  4. Unified selective sorting approach to analyse multi-electrode extracellular data

    NASA Astrophysics Data System (ADS)

    Veerabhadrappa, R.; Lim, C. P.; Nguyen, T. T.; Berk, M.; Tye, S. J.; Monaghan, P.; Nahavandi, S.; Bhatti, A.

    2016-06-01

    Extracellular data analysis has become a quintessential method for understanding the neurophysiological responses to stimuli. This demands stringent techniques owing to the complicated nature of the recording environment. In this paper, we highlight the challenges in extracellular multi-electrode recording and data analysis as well as the limitations pertaining to some of the currently employed methodologies. To address some of the challenges, we present a unified algorithm in the form of selective sorting. Selective sorting is modelled around hypothesized generative model, which addresses the natural phenomena of spikes triggered by an intricate neuronal population. The algorithm incorporates Cepstrum of Bispectrum, ad hoc clustering algorithms, wavelet transforms, least square and correlation concepts which strategically tailors a sequence to characterize and form distinctive clusters. Additionally, we demonstrate the influence of noise modelled wavelets to sort overlapping spikes. The algorithm is evaluated using both raw and synthesized data sets with different levels of complexity and the performances are tabulated for comparison using widely accepted qualitative and quantitative indicators.

  5. ERAIZDA: a model for holistic annotation of animal infectious and zoonotic diseases

    PubMed Central

    Buza, Teresia M.; Jack, Sherman W.; Kirunda, Halid; Khaitsa, Margaret L.; Lawrence, Mark L.; Pruett, Stephen; Peterson, Daniel G.

    2015-01-01

    There is an urgent need for a unified resource that integrates trans-disciplinary annotations of emerging and reemerging animal infectious and zoonotic diseases. Such data integration will provide wonderful opportunity for epidemiologists, researchers and health policy makers to make data-driven decisions designed to improve animal health. Integrating emerging and reemerging animal infectious and zoonotic disease data from a large variety of sources into a unified open-access resource provides more plausible arguments to achieve better understanding of infectious and zoonotic diseases. We have developed a model for interlinking annotations of these diseases. These diseases are of particular interest because of the threats they pose to animal health, human health and global health security. We demonstrated the application of this model using brucellosis, an infectious and zoonotic disease. Preliminary annotations were deposited into VetBioBase database (http://vetbiobase.igbb.msstate.edu). This database is associated with user-friendly tools to facilitate searching, retrieving and downloading of disease-related information. Database URL: http://vetbiobase.igbb.msstate.edu PMID:26581408

  6. A unified model of Grignard reagent formation.

    PubMed

    Shao, Yunqi; Liu, Zhen; Huang, Pan; Liu, Boping

    2018-04-25

    Grignard reagents are among the most fundamental reagents in organic synthesis, yet studies have hitherto failed to fully explain the selectivity and kinetics of Grignard reagent formation (GRF). The present study provides new insights into the intermediates and pathways of GRF using density functional theory (DFT) calculations. Potential energy surfaces of RX dissociation along different directions reveal the origin of configuration retention of alkenyl and aromatic halides. Radical intermediates participate solely in the dissociation stage, and depend on the geometry of the reactant halide. Dissociation of organic halides yields stabilized surface anions, and the rest of the reaction is ionic in nature. MgX+/RMg+ were proposed as the key intermediates of Mg leaving from the surface in the self-activation of GRF, which explains the accelerated kinetics upon addition of RMgX or MgX2. The intermediacy of the cations was supported by a simple electrochemical experiment. To the best of our knowledge, this is the first unified ionic model (I-model) developed for resolving the controversial issues of GRF.

  7. Unified Theory for Aircraft Handling Qualities and Adverse Aircraft-Pilot Coupling

    NASA Technical Reports Server (NTRS)

    Hess, R. A.

    1997-01-01

    A unified theory for aircraft handling qualities and adverse aircraft-pilot coupling or pilot-induced oscillations is introduced. The theory is based on a structural model of the human pilot. A methodology is presented for the prediction of (1) handling qualities levels; (2) pilot-induced oscillation rating levels; and (3) a frequency range in which pilot-induced oscillations are likely to occur. Although the dynamics of the force-feel system of the cockpit inceptor is included, the methodology will not account for effects attributable to control sensitivity and is limited to single-axis tasks and, at present, to linear vehicle models. The theory is derived from the feedback topology of the structural model and an examination of flight test results for 32 aircraft configurations simulated by the U.S. Air Force/CALSPAN NT-33A and Total In-Flight Simulator variable stability aircraft. An extension to nonlinear vehicle dynamics such as that encountered with actuator saturation is discussed.

  8. Generalized thermoelastic problem of an infinite body with a spherical cavity under dual-phase-lags

    NASA Astrophysics Data System (ADS)

    Karmakar, R.; Sur, A.; Kanoria, M.

    2016-07-01

    The aim of the present contribution is the determination of the thermoelastic temperatures, stress, displacement, and strain in an infinite isotropic elastic body with a spherical cavity in the context of the mechanism of the two-temperature generalized thermoelasticity theory (2TT). The two-temperature Lord-Shulman (2TLS) model and two-temperature dual-phase-lag (2TDP) model of thermoelasticity are combined into a unified formulation with unified parameters. The medium is assumed to be initially quiescent. The basic equations are written in the form of a vector matrix differential equation in the Laplace transform domain, which is then solved by the state-space approach. The expressions for the conductive temperature and elongation are obtained at small times. The numerical inversion of the transformed solutions is carried out by using the Fourier-series expansion technique. A comparative study is performed for the thermoelastic stresses, conductive temperature, thermodynamic temperature, displacement, and elongation computed by using the Lord-Shulman and dual-phase-lag models.

  9. Unified selective sorting approach to analyse multi-electrode extracellular data

    PubMed Central

    Veerabhadrappa, R.; Lim, C. P.; Nguyen, T. T.; Berk, M.; Tye, S. J.; Monaghan, P.; Nahavandi, S.; Bhatti, A.

    2016-01-01

    Extracellular data analysis has become a quintessential method for understanding the neurophysiological responses to stimuli. This demands stringent techniques owing to the complicated nature of the recording environment. In this paper, we highlight the challenges in extracellular multi-electrode recording and data analysis as well as the limitations pertaining to some of the currently employed methodologies. To address some of the challenges, we present a unified algorithm in the form of selective sorting. Selective sorting is modelled around hypothesized generative model, which addresses the natural phenomena of spikes triggered by an intricate neuronal population. The algorithm incorporates Cepstrum of Bispectrum, ad hoc clustering algorithms, wavelet transforms, least square and correlation concepts which strategically tailors a sequence to characterize and form distinctive clusters. Additionally, we demonstrate the influence of noise modelled wavelets to sort overlapping spikes. The algorithm is evaluated using both raw and synthesized data sets with different levels of complexity and the performances are tabulated for comparison using widely accepted qualitative and quantitative indicators. PMID:27339770

  10. Time-dependent transport of energetic particles in magnetic turbulence: computer simulations versus analytical theory

    NASA Astrophysics Data System (ADS)

    Arendt, V.; Shalchi, A.

    2018-06-01

    We explore numerically the transport of energetic particles in a turbulent magnetic field configuration. A test-particle code is employed to compute running diffusion coefficients as well as particle distribution functions in the different directions of space. Our numerical findings are compared with models commonly used in diffusion theory such as Gaussian distribution functions and solutions of the cosmic ray Fokker-Planck equation. Furthermore, we compare the running diffusion coefficients across the mean magnetic field with solutions obtained from the time-dependent version of the unified non-linear transport theory. In most cases we find that particle distribution functions are indeed of Gaussian form as long as a two-component turbulence model is employed. For turbulence setups with reduced dimensionality, however, the Gaussian distribution can no longer be obtained. It is also shown that the unified non-linear transport theory agrees with simulated perpendicular diffusion coefficients as long as the pure two-dimensional model is excluded.

  11. An Abstract Process and Metrics Model for Evaluating Unified Command and Control: A Scenario and Technology Agnostic Approach

    DTIC Science & Technology

    2004-06-01

    18 EBO Cognitive or Memetic input type ..................................................................... 18 Unanticipated EBO generated... Memetic Effects Based COA.................................................................................... 23 Policy...41 Belief systems or Memetic Content Metrics

  12. Theory Creation, Modification, and Testing: An Information-Processing Model and Theory of the Anticipated and Unanticipated Consequences of Research and Development

    ERIC Educational Resources Information Center

    Perla, Rocco J.; Carifio, James

    2011-01-01

    Background: Extending Merton's (1936) work on the consequences of purposive social action, the model, theory and taxonomy outlined here incorporates and formalizes both anticipated and unanticipated research findings in a unified theoretical framework. The model of anticipated research findings was developed initially by Carifio (1975, 1977) and…

  13. Using an Agenda Setting Model to Help Students Develop & Exercise Participatory Skills and Values

    ERIC Educational Resources Information Center

    Perry, Anthony D.; Wilkenfeld, Britt S.

    2006-01-01

    The Agenda Setting Model is a program component that can be used in courses to contribute to students' development as responsible, effective, and informed citizens. This model involves students in finding a unified voice to assert an agenda of issues that they find especially pressing. This is often the only time students experience such a…

  14. A Unified Model of Student Engagement in Classroom Learning and Classroom Learning Environment: One Measure and One Underlying Construct

    ERIC Educational Resources Information Center

    Cavanagh, Robert F.

    2015-01-01

    This study employed the capabilities-expectations model of engagement in classroom learning based on bio-ecological frameworks of intellectual development and flow theory. According to the capabilities-expectations model, engagement requires a balance between the capabilities of a student for learning in a particular situation and what is expected…

  15. A Proposed Pattern of Enterprise Architecture

    DTIC Science & Technology

    2013-02-01

    consistent architecture descriptions. UPDM comprises extensions to both OMG’s Unified Modelling Language (UML) and Systems Modelling Language ( SysML ...those who use UML and SysML . These represent significant advancements that enable architecture trade-off analyses, architecture model execution...Language ( SysML ), and thus provides for architectural descriptions that contain a rich set of (formally) connected DoDAF/MoDAF viewpoints expressed

  16. A Unifying Mechanistic Model of Selective Attention in Spiking Neurons

    PubMed Central

    Bobier, Bruce; Stewart, Terrence C.; Eliasmith, Chris

    2014-01-01

    Visuospatial attention produces myriad effects on the activity and selectivity of cortical neurons. Spiking neuron models capable of reproducing a wide variety of these effects remain elusive. We present a model called the Attentional Routing Circuit (ARC) that provides a mechanistic description of selective attentional processing in cortex. The model is described mathematically and implemented at the level of individual spiking neurons, with the computations for performing selective attentional processing being mapped to specific neuron types and laminar circuitry. The model is used to simulate three studies of attention in macaque, and is shown to quantitatively match several observed forms of attentional modulation. Specifically, ARC demonstrates that with shifts of spatial attention, neurons may exhibit shifting and shrinking of receptive fields; increases in responses without changes in selectivity for non-spatial features (i.e. response gain), and; that the effect on contrast-response functions is better explained as a response-gain effect than as contrast-gain. Unlike past models, ARC embodies a single mechanism that unifies the above forms of attentional modulation, is consistent with a wide array of available data, and makes several specific and quantifiable predictions. PMID:24921249

  17. Forecasting of monsoon heavy rains: challenges in NWP

    NASA Astrophysics Data System (ADS)

    Sharma, Kuldeep; Ashrit, Raghavendra; Iyengar, Gopal; Bhatla, R.; Rajagopal, E. N.

    2016-05-01

    Last decade has seen a tremendous improvement in the forecasting skill of numerical weather prediction (NWP) models. This is attributed to increased sophistication in NWP models, which resolve complex physical processes, advanced data assimilation, increased grid resolution and satellite observations. However, prediction of heavy rains is still a challenge since the models exhibit large error in amounts as well as spatial and temporal distribution. Two state-of-art NWP models have been investigated over the Indian monsoon region to assess their ability in predicting the heavy rainfall events. The unified model operational at National Center for Medium Range Weather Forecasting (NCUM) and the unified model operational at the Australian Bureau of Meteorology (Australian Community Climate and Earth-System Simulator -- Global (ACCESS-G)) are used in this study. The recent (JJAS 2015) Indian monsoon season witnessed 6 depressions and 2 cyclonic storms which resulted in heavy rains and flooding. The CRA method of verification allows the decomposition of forecast errors in terms of error in the rainfall volume, pattern and location. The case by case study using CRA technique shows that contribution to the rainfall errors come from pattern and displacement is large while contribution due to error in predicted rainfall volume is least.

  18. Toward a Transdisciplinary Model of Evidence-Based Practice

    PubMed Central

    Satterfield, Jason M; Spring, Bonnie; Brownson, Ross C; Mullen, Edward J; Newhouse, Robin P; Walker, Barbara B; Whitlock, Evelyn P

    2009-01-01

    Context This article describes the historical context and current developments in evidence-based practice (EBP) for medicine, nursing, psychology, social work, and public health, as well as the evolution of the seminal “three circles” model of evidence-based medicine, highlighting changes in EBP content, processes, and philosophies across disciplines. Methods The core issues and challenges in EBP are identified by comparing and contrasting EBP models across various health disciplines. Then a unified, transdisciplinary EBP model is presented, drawing on the strengths and compensating for the weaknesses of each discipline. Findings Common challenges across disciplines include (1) how “evidence” should be defined and comparatively weighted; (2) how and when the patient's and/or other contextual factors should enter the clinical decision-making process; (3) the definition and role of the “expert”; and (4) what other variables should be considered when selecting an evidence-based practice, such as age, social class, community resources, and local expertise. Conclusions A unified, transdisciplinary EBP model would address historical shortcomings by redefining the contents of each model circle, clarifying the practitioner's expertise and competencies, emphasizing shared decision making, and adding both environmental and organizational contexts. Implications for academia, practice, and policy also are discussed. PMID:19523122

  19. A Unified Computational Model for Solar and Stellar Flares

    NASA Technical Reports Server (NTRS)

    Allred, Joel C.; Kowalski, Adam F.; Carlsson, Mats

    2015-01-01

    We present a unified computational framework that can be used to describe impulsive flares on the Sun and on dMe stars. The models assume that the flare impulsive phase is caused by a beam of charged particles that is accelerated in the corona and propagates downward depositing energy and momentum along the way. This rapidly heats the lower stellar atmosphere causing it to explosively expand and dramatically brighten. Our models consist of flux tubes that extend from the sub-photosphere into the corona. We simulate how flare-accelerated charged particles propagate down one-dimensional flux tubes and heat the stellar atmosphere using the Fokker-Planck kinetic theory. Detailed radiative transfer is included so that model predictions can be directly compared with observations. The flux of flare-accelerated particles drives return currents which additionally heat the stellar atmosphere. These effects are also included in our models. We examine the impact of the flare-accelerated particle beams on model solar and dMe stellar atmospheres and perform parameter studies varying the injected particle energy spectra. We find the atmospheric response is strongly dependent on the accelerated particle cutoff energy and spectral index.

  20. Unified Deep Learning Architecture for Modeling Biology Sequence.

    PubMed

    Wu, Hongjie; Cao, Chengyuan; Xia, Xiaoyan; Lu, Qiang

    2017-10-09

    Prediction of the spatial structure or function of biological macromolecules based on their sequence remains an important challenge in bioinformatics. When modeling biological sequences using traditional sequencing models, characteristics, such as long-range interactions between basic units, the complicated and variable output of labeled structures, and the variable length of biological sequences, usually lead to different solutions on a case-by-case basis. This study proposed the use of bidirectional recurrent neural networks based on long short-term memory or a gated recurrent unit to capture long-range interactions by designing the optional reshape operator to adapt to the diversity of the output labels and implementing a training algorithm to support the training of sequence models capable of processing variable-length sequences. Additionally, the merge and pooling operators enhanced the ability to capture short-range interactions between basic units of biological sequences. The proposed deep-learning model and its training algorithm might be capable of solving currently known biological sequence-modeling problems through the use of a unified framework. We validated our model on one of the most difficult biological sequence-modeling problems currently known, with our results indicating the ability of the model to obtain predictions of protein residue interactions that exceeded the accuracy of current popular approaches by 10% based on multiple benchmarks.

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