Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-04

NASA Technical Reports Server (NTRS)

Bauman, William; Wheeler, Mark; Lambert, Winifred; Case, Jonathan; Short, David

2004-01-01

This report summarizes the Applied Meteorology Unit (A MU) activities for the fourth quarter of Fiscal Year 2004 (July -Sept 2004). Tasks covered are: (1) Objective Lightning Probability Forecast: Phase I, (2) Severe Weather Forecast Decision Aid, (3) Hail Index, (4) Shuttle Ascent Camera Cloud Obstruction Forecast, (5) Advanced Regional Prediction System (ARPS) Optimization and Training Extension and (5) User Control Interface for ARPS Data Analysis System (ADAS) Data Ingest.

The Applied Meteorology Unit: Nineteen Years Successfully Transitioning Research Into Operations for America's Space Program

NASA Technical Reports Server (NTRS)

Madura, John T.; Bauman, William H., III; Merceret, Francis J.; Roeder, William P.; Brody, Frank C.; Hagemeyer, Bartlett C.

2011-01-01

The Applied Meteorology Unit (AMU) provides technology development and transition services to improve operational weather support to America's space program . The AMU was founded in 1991 and operates under a triagency Memorandum of Understanding (MOU) between the National Aeronautics and Space Administration (NASA), the United States Air Force (USAF) and the National Weather Service (NWS) (Ernst and Merceret, 1995). It is colocated with the 45th Weather Squadron (45WS) at Cape Canaveral Air Force Station (CCAFS) and funded by the Space Shuttle Program . Its primary customers are the 45WS, the Spaceflight Meteorology Group (SMG) operated for NASA by the NWS at the Johnson Space Center (JSC) in Houston, TX, and the NWS forecast office in Melbourne, FL (MLB). The gap between research and operations is well known. All too frequently, the process of transitioning research to operations fails for various reasons. The mission of the AMU is in essence to bridge this gap for America's space program.

Recent Weather Technologies Delivered to America's Space Program by the Applied Meteorology Unit

NASA Technical Reports Server (NTRS)

Bauman, WIlliam, H., III; Crawford, Winifred

2009-01-01

The Applied Meteorology Unit (AMU) is a unique joint venture of NASA, the Air Force and the National Weather Service (NWS) and has been supporting the Space Program for nearly two decades. The AMU acts as a bridge between the meteorological research community and operational forecasters by developing, evaluating and transitioning new technology and techniques to improve weather support to spaceport operations at the Eastern Range (ER) and Kennedy Space Center. Its primary customers are the 45th Weather Squadron at Cape Canaveral Air Force Station (CCAFS), the Spaceflight Meteorology Group at Johnson Space Center and the National Weather Service Office in Melbourne, FL. Its products are used to support NASA's Shuttle and ELV programs as well as Department of Defense and commercial launches from the ER. Shuttle support includes landing sites beyond the ER. The AMU is co-located with the Air Force operational forecasters at CCAFS to facilitate continuous two-way interaction between the AMU and its operational customers. It is operated under a NASA, Air Force, and NWS Memorandum of Understanding (MOU) by a competitively-selected contractor. The contract, which is funded and managed by NASA, provides five full time professionals with degrees in meteorology or related fields, some of whom also have operational experience. NASA provides a Ph.D.- level NASA civil service scientist as Chief of the AMU. The AMU is tasked by its customers through a unique, nationally recognized process. The tasks are limited to development, evaluation and operational transition of technology to improve weather support to spaceport operations and providing expert advice to the customers. The MOU expressly forbids using the AMU resources to conduct operations or do basic research. The presentation will provide a brief overview of the AMU and how it is tasked by its customers to provide high priority products and services. The balance of the presentation will cover a sampling of products delivered over the last 18 years that are currently in operational use. Each example will describe the problem to be solved, the solution provided, and the operational benefits of implementing that solution.

Applied Meteorology Unit - Operational Contributions to Spaceport Canaveral

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Roeder, William P.; Lafosse, Richard A.; Sharp, David W.; Merceret, Francis J.

2004-01-01

The Applied Meteorology Unit (AMU) provides technology development, evaluation and transition services to improve operational weather support to the Space Shuttle and the National Space Program. It is established under a Memorandum of Understanding among NASA, the Air Force and the National .Weather Service (NWS). The AMU is funded and managed by NASA and operated by ENSCO, Inc. through a competitively awarded NASA contract. The primary customers are the 45th Weather Squadron (45WS) at Cape Canaveral Air Force Station (CCAFS), FL; the Spaceflight Meteorology Group (SMG) at Johnson Space Center (JSC) in Houston, TX; and the NWS office in Melbourne, FL (NWS MLB). This paper will briefly review the AMU's history and describe the three processes through which its work is assigned. Since its inception in 1991 the AMU has completed 72 projects, all of which are listed at the end of this paper. At least one project that highlights each of the three tasking processes will be briefly reviewed. Some of the projects that have been especially beneficial to the space program will also be discussed in more detail, as will projects that developed significant new techniques or science in applied meteorology.

Applied Meteorology Unit (AMU) Quarterly Report

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Wheeler, Mark

2011-01-01

This Quarter's Highlights include reports on the following tasks: (1) Mr. Wheeler completed a study for the 30th Weather Squadron at Vandenberg Air Force Base in California in which he found precursors in weather observations that will help the forecasters determine when they will get strong wind gusts at their northern towers. The final report is now on the AMU website at http://science.ksc.nasa.gov/amu/final-reports/30ws-north-base-winds.pdf. (2) continued work on the second phase of verifying the performance of the MesoNAM weather model at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). (3) continued work to improve the AMU peak wind tool by analyzing wind tower data to determine peak wind behavior during times of onshore and offshore flow. (4) continued updating lightning c1imatologies for KSC/CCAFS and other airfields around central Florida and created new c1imatologies for moisture and stability thresholds.

Real-Time Kennedy Space Center and Cape Canaveral Air Force Station High-Resolution Model Implementation and Verification

NASA Technical Reports Server (NTRS)

Shafer, Jaclyn A.; Watson, Leela R.

2015-01-01

Customer: NASA's Launch Services Program (LSP), Ground Systems Development and Operations (GSDO), and Space Launch System (SLS) programs. NASA's LSP, GSDO, SLS and other programs at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) use the daily and weekly weather forecasts issued by the 45th Weather Squadron (45 WS) as decision tools for their day-to-day and launch operations on the Eastern Range (ER). For example, to determine if they need to limit activities such as vehicle transport to the launch pad, protect people, structures or exposed launch vehicles given a threat of severe weather, or reschedule other critical operations. The 45 WS uses numerical weather prediction models as a guide for these weather forecasts, particularly the Air Force Weather Agency (AFWA) 1.67 kilometer Weather Research and Forecasting (WRF) model. Considering the 45 WS forecasters' and Launch Weather Officers' (LWO) extensive use of the AFWA model, the 45 WS proposed a task at the September 2013 Applied Meteorology Unit (AMU) Tasking Meeting requesting the AMU verify this model. Due to the lack of archived model data available from AFWA, verification is not yet possible. Instead, the AMU proposed to implement and verify the performance of an ER version of the AMU high-resolution WRF Environmental Modeling System (EMS) model (Watson 2013) in real-time. The tasking group agreed to this proposal; therefore the AMU implemented the WRF-EMS model on the second of two NASA AMU modeling clusters. The model was set up with a triple-nested grid configuration over KSC/CCAFS based on previous AMU work (Watson 2013). The outer domain (D01) has 12-kilometer grid spacing, the middle domain (D02) has 4-kilometer grid spacing, and the inner domain (D03) has 1.33-kilometer grid spacing. The model runs a 12-hour forecast every hour, D01 and D02 domain outputs are available once an hour and D03 is every 15 minutes during the forecast period. The AMU assessed the WRF-EMS 1.33-kilometer domain model performance for the 2014 warm season (May-September). Verification statistics were computed using the Model Evaluation Tools, which compared the model forecasts to observations. The mean error values were close to 0 and the root mean square error values were less than 1.8 for mean sea-level pressure (millibars), temperature (degrees Kelvin), dewpoint temperature (degrees Kelvin), and wind speed (per millisecond), all very small differences between the forecast and observations considering the normal magnitudes of the parameters. The precipitation forecast verification results showed consistent under-forecasting of the precipitation object size. This could be an artifact of calculating the statistics for each hour rather than for the entire 12-hour period. The AMU will continue to generate verification statistics for the 1.33-kilometer WRF-EMS domain as data become available in future cool and warm seasons. More data will produce more robust statistics and reveal a more accurate assessment of model performance. Once the formal task was complete, the AMU conducted additional work to better understand the wind direction results. The results were stratified diurnally and by wind speed to determine what effects the stratifications would have on the model wind direction verification statistics. The results are summarized in the addendum at the end of this report. In addition to verifying the model's performance, the AMU also made the output available in the Advanced Weather Interactive Processing System II (AWIPS II). This allows the 45 WS and AMU staff to customize the model output display on the AMU and Range Weather Operations AWIPS II client computers and conduct real-time subjective analyses. In the future, the AMU will implement an updated version of the WRF-EMS model that incorporates local data assimilation. This model will also run in real-time and be made available in AWIPS II.

Situational Lightning Climatologies for Central Florida: Phase IV: Central Florida Flow Regime Based Climatologies of Lightning Probabilities

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2009-01-01

The threat of lightning is a daily concern during the warm season in Florida. Research has revealed distinct spatial and temporal distributions of lightning occurrence that are strongly influenced by large-scale atmospheric flow regimes. Previously, the Applied Meteorology Unit (AMU) calculated the gridded lightning climatologies based on seven flow regimes over Florida for 1-, 3- and 6-hr intervals in 5-, 10-, 20-, and 30-NM diameter range rings around the Shuttle Landing Facility (SLF) and eight other airfields in the National Weather Service in Melbourne (NWS MLB) county warning area (CWA). In this update to the work, the AMU recalculated the lightning climatologies for using individual lightning strike data to improve the accuracy of the climatologies. The AMU included all data regardless of flow regime as one of the stratifications, added monthly stratifications, added three years of data to the period of record and used modified flow regimes based work from the AMU's Objective Lightning Probability Forecast Tool, Phase II. The AMU made changes so the 5- and 10-NM radius range rings are consistent with the aviation forecast requirements at NWS MLB, while the 20- and 30-NM radius range rings at the SLF assist the Spaceflight Meteorology Group in making forecasts for weather Flight Rule violations during Shuttle landings. The AMU also updated the graphical user interface with the new data.

Situational Lightning Climatologies for Central Florida: Phase IV

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2009-01-01

The threat of lightning is a daily concern during the warm season in Florida. Research has revealed distinct spatial and temporal distributions of lightning occurrence that are strongly influenced by large-scale atmospheric flow regimes. Previously, the Applied Meteorology Unit (AMU) calculated the gridded lightning climatologies based on seven flow regimes over Florida for 1-, 3- and 6-hr intervals in 5-, 10-,20-, and 30-NM diameter range rings around the Shuttle Landing Facility (SLF) and eight other airfields in the National Weather Service in Melbourne (NWS MLB) county warning area (CWA). In this update to the work, the AMU recalculated the lightning climatologies for using individual lightning strike data to improve the accuracy of the climatologies. The AMU included all data regardless of flow regime as one of the stratifications, added monthly stratifications, added three years of data to the period of record and used modified flow regimes based work from the AMU's Objective Lightning Probability Forecast Tool, Phase II. The AMU made changes so the 5- and 10-NM radius range rings are consistent with the aviation forecast requirements at NWS MLB, while the 20- and 30-NM radius range rings at the SLF assist the Spaceflight Meteorology Group in making forecasts for weather Flight Rule violations during Shuttle landings. The AMU also updated the graphical user interface with the new data.

Radiation Internal Monitoring by In Vivo Scanning in Operation Tomodachi

DTIC Science & Technology

2013-08-01

2 cubic meter (m3) Mass /Density pound (lb) 4.535 924 × 10–1 kilogram (kg) atomic mass unit (AMU) 1.660 539 × 10–27 kilogram (kg) pound- mass per...40 2.2.5. Critical Level and Minimum Detectable Activity ............................... 42 ii Section 3. Radiological Properties...operation quality assurance program. x Operation Tomodachi Dose Assessment and Recording Working Group members, who provided critical information

Gemini 9 configured extravehicular spacesuit assembly

NASA Image and Video Library

1966-05-01

S66-31019 (May 1966) --- Test subject Fred Spross, Crew Systems Division, wears the Gemini-9 configured extravehicular spacesuit assembly. The legs are covered with Chromel R, which is a cloth woven from stainless steel fibers, used to protect the astronaut and suit from the hot exhaust thrust of the Astronaut Maneuvering Unit (AMU). Astronaut Eugene A. Cernan will wear this spacesuit during his Gemini-9A extravehicular activity (EVA). Photo credit: NASA

Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32

PubMed Central

Boeckstaens, Mélanie; Merhi, Ahmad; Llinares, Elisa; Van Vooren, Pascale; Springael, Jean-Yves; Wintjens, René; Marini, Anna Maria

2015-01-01

Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are integrated by the TORC1 complex which notably regulates arrestin-mediated endocytosis of amino-acid transporters. Ammonium is a ubiquitous compound playing key physiological roles in many, if not all, organisms. In yeast, it is a preferred nitrogen source transported by three Mep proteins which are orthologues of the mammalian Rhesus factors. By combining genetic, kinetic, biochemical and cell microscopy analyses, the current study reveals a novel mechanism enabling TORC1 to regulate the inherent activity of ammonium transport proteins, independently of arrestin-mediated endocytosis, identifying the still functional orphan Amu1/Par32 as a selective regulator intermediate. We show that, under poor nitrogen supply, the TORC1 effector kinase' Npr1' promotes phosphorylation of Amu1/Par32 which appears mainly cytosolic while ammonium transport proteins are active. Upon preferred nitrogen supplementation, like glutamine or ammonium addition, TORC1 upregulation enables Npr1 inhibition and Amu1/Par32 dephosphorylation. In these conditions, as in Npr1-lacking cells, hypophosphorylated Amu1/Par32 accumulates at the cell surface and mediates the inhibition of specific ammonium transport proteins. We show that the integrity of a conserved repeated motif of Amu1/Par32 is required for the interaction with these transport proteins. This study underscores the diversity of strategies enabling TORC1-Npr1 to selectively monitor cell permeability to nutrients by discriminating between transporters to be degraded or transiently inactivated and kept stable at the plasma membrane. This study further identifies the function of Amu1/Par32 in acute control of ammonium transport in response to variations in nitrogen availability. PMID:26172854

Applied Meteorology Unit (AMU) Quarterly Report - Fourth Quarter FY-10

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Barrett, Joe; Watson, Leela; Wheeler, Mark

2010-01-01

Three AMU tasks were completed in this Quarter, each resulting in a forecast tool now being used in operations and a final report documenting how the work was done. AMU personnel completed the following tasks (1) Phase II of the Peak Wind Tool for General Forecasting task by delivering an improved wind forecasting tool to operations and providing training on its use; (2) a graphical user interface (GUI) she updated with new scripts to complete the ADAS Update and Maintainability task, and delivered the scripts to the Spaceflight Meteorology Group on Johnson Space Center, Texas and National Weather Service in Melbourne, Fla.; and (3) the Verify MesoNAM Performance task after we created and delivered a GUI that forecasters will use to determine the performance of the operational MesoNAM weather model forecast.

Astronaut Gene Cernan poses in front of Gemini Mission Simulator

NASA Image and Video Library

1966-08-09

S66-32698 (17 June 1966) --- Astronaut Eugene A. Cernan discusses his Gemini-9A extravehicular activity before a gathering of news media representatives in the MSC auditorium. In the background is an Astronaut Maneuvering Unit (AMU) mock-up mounted in a mock-up of a Gemini spacecraft adapter equipment section. Astronauts Cernan and Thomas P. Stafford completed their three-day mission in space on June 6, 1966. Photo credit: NASA

Applied Meteorology Unit (AMU)

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Wheeler, Mark

2011-01-01

The AMU Team began four new tasks in this quarter: (1) began work to improve the AMU-developed tool that provides the launch weather officers information on peak wind speeds that helps them assess their launch commit criteria; (2) began updating lightning climatologies for airfields around central Florida. These climatologies help National Weather Service and Air Force forecasters determine the probability of lightning occurrence at these sites; (3) began a study for the 30th Weather Squadron at Vandenberg Air Force Base in California to determine if precursors can be found in weather observations to help the forecasters determine when they will get strong wind gusts in their northern towers; and (4) began work to update the AMU-developed severe weather tool with more data and possibly improve its performance using a new statistical technique. Include is a section of summaries and detail reporting on the quarterly tasks: (1) Peak Wind Tool for user Meteorological Interactive Data Display System (LCC), Phase IV, (2) Situational Lightning climatologies for Central Florida, Phase V, (3) Vandenberg AFB North Base Wind Study and (4) Upgrade Summer Severe Weather Tool Meteorological Interactive Data Display System (MIDDS).

Assessment of Non-Traditional Isotopic Ratios by Mass Spectrometry for Analysis of Nuclear Activities

DTIC Science & Technology

2016-03-01

Assessment of Non-traditional Isotopic Ratios by Mass Spectrometry for Analysis of Nuclear Activities Distribution Statement A. Approved for pubic...cubic meter (m 3 ) cubic foot (ft 3 ) 2.831 685 × 10 –2 cubic meter (m 3 ) Mass /Density pound (lb) 4.535 924 × 10 –1 kilogram (kg) unified...atomic mass unit (amu) 1.660 539 × 10 –27 kilogram (kg) pound- mass per cubic foot (lb ft –3 ) 1.601 846 × 10 1 kilogram per cubic meter (kg m –3

Petroleum geology and resources of the Amu-Darya basin, Turkmenistan, Uzbekistan, Afghanistan, and Iran

USGS Publications Warehouse

Ulmishek, Gregory F.

2004-01-01

The Amu-Darya basin is a highly productive petroleum province in Turkmenistan and Uzbekistan (former Soviet Union), extending southwestward into Iran and southeastward into Afghanistan. The basin underlies deserts and semideserts north of the high ridges of the Kopet-Dag and Bande-Turkestan Mountains. On the northwest, the basin boundary crosses the crest of the Karakum regional structural high, and on the north the basin is bounded by the shallow basement of the Kyzylkum high. On the east, the Amu-Darya basin is separated by the buried southeast spur of the Gissar Range from the Afghan-Tajik basin, which is deformed into a series of north-south-trending synclinoria and anticlinoria. The separation of the two basins occurred during the Neogene Alpine orogeny; earlier, they were parts of a single sedimentary province. The basement of the Amu-Darya basin is a Hercynian accreted terrane composed of deformed and commonly metamorphosed Paleozoic rocks. These rocks are overlain by rift grabens filled with Upper Permian-Triassic rocks that are strongly compacted and diagenetically altered. This taphrogenic sequence, also considered to be a part of the economic basement, is overlain by thick Lower to Middle Jurassic, largely continental, coal-bearing rocks. The overlying Callovian-Oxfordian rocks are primarily carbonates. A deep-water basin surrounded by shallow shelves with reefs along their margins was formed during this time and reached its maximum topographic expression in the late Oxfordian. In Kimmeridgian-Tithonian time, the basin was filled with thick evaporites of the Gaurdak Formation. The Cretaceous-Paleogene sequence is composed chiefly of marine clastic rocks with carbonate intervals prominent in the Valanginian, Barremian, Maastrichtian, and Paleocene stratigraphic units. In Neogene time, the Alpine orogeny on the basin periphery resulted in deposition of continental clastics, initiation of new and rejuvenation of old faults, and formation of most structural traps. A single total petroleum system is identified in the Amu-Darya basin. The system is primarily gas prone. Discovered gas reserves are listed by Petroconsultants (1996) at about 230 trillion cubic feet, but recent discoveries and recent reserve estimates in older fields should increase this number by 40 to 50 trillion cubic feet. Reserves of liquid hydrocarbons (oil and condensate) are comparatively small, less than 2 billion barrels. Most of the gas reserves are concentrated in two stratigraphic intervals, Upper Jurassic carbonates and Neocomian clastics, each of which contains about one-half of the reserves. Reserves of other stratigraphic units?from Middle Jurassic to Paleogene in age?are relatively small. Source rocks for the gas are the Lower to Middle Jurassic clastics and coal and Oxfordian basinal black shales in the east-central part of the basin. The latter is probably responsible for the oil legs and much of the condensate in gas pools. Throughout most of the basin both source-rock units are presently in the gas-window zone. Traps are structural, paleogeomorphic, and stratigraphic, as well as a combination of these types. The giant Dauletabad field is in a combination trap with an essential hydrodynamic component. Four assessment units were identified in the total petroleum system. One unit in the northeastern, northern, and northwestern marginal areas of the basin and another in the southern marginal area are characterized by wide vertical distribution of hydrocarbon pools in Middle Jurassic to Paleocene rocks and the absence of the salt of the Gaurdak Formation. The other two assessment units are stratigraphically stacked; they occupy the central area of the basin and are separated by the regional undeformed salt seal of the Gaurdak Formation. The largest part of undiscovered hydrocarbon resources of the Amu-Darya basin is expected in older of these assessment units. The mean value of total assessed resources of the Amu-Darya basin is estimated

Cosmic-ray elemental abundances from 1 to 10 GeV per amu for boron through nickel

NASA Technical Reports Server (NTRS)

Dwyer, Robert; Meyer, Peter

1987-01-01

The relative abundances of cosmic-ray nuclei in the charge range boron through nickel over the energy range 1-10 GeV per amu were measured with a balloon-borne detector. The instrument consists of a scintillation and Cerenkov counter telescope with a multiwire proportional chamber hodoscope and has been flown in four high-altitude balloon flights. Good charge resolution (sigma = 0.2 charge units at iron) and high statistical accuracy have been achieved. These data are used to derive the energy dependence of the leakage path length using the leaky box model of propagation and confinement in the galaxy. This energy dependence is found to be best fit by lambda = E(tot) exp -n, where n = 0.49 + or - 0.06 over 1-10 GeV per amu. Relative abundances at the source are consistent with an energy-independent composition.

First Cloud-to-Ground Lightning Timing Study

NASA Technical Reports Server (NTRS)

Huddleston, Lisa L.

2013-01-01

NASA's LSP, GSDO and other programs use the probability of cloud-to-ground (CG) lightning occurrence issued by the 45th Weather Squadron (45 WS) in their daily and weekly lightning probability forecasts. These organizations use this information when planning potentially hazardous outdoor activities, such as working with fuels, or rolling a vehicle to a launch pad, or whenever personnel will work outside and would be at-risk from lightning. These organizations would benefit greatly if the 45 WS could provide more accurate timing of the first CG lightning strike of the day. The Applied Meteorology Unit (AMU) has made significant improvements in forecasting the probability of lightning for the day, but forecasting the time of the first CG lightning with confidence has remained a challenge. To address this issue, the 45 WS requested the AMU to determine if flow regimes, wind speed categories, or a combination of the two could be used to forecast the timing of the first strike of the day in the Kennedy Space Center (KSC)/Cape Canaveral Air Force Station (CCAFS) lightning warning circles. The data was stratified by various sea breeze flow regimes and speed categories in the surface to 5,000-ft layer. The surface to 5,000-ft layer was selected since that is the layer the 45 WS uses to predict the behavior of sea breeze fronts, which are the dominant influence on the occurrence of first lightning in Florida during the warm season. Due to small data sample sizes after stratification, the AMU could not determine a statistical relationship between flow regimes or speed categories and the time of the first CG strike.. As expected, although the amount and timing of lightning activity varies by time of day based on the flow regimes and speed categories, there are extended tails of low lightning activity making it difficult to specify times when the threat of the first lightning flash can be avoided. However, the AMU developed a graphical user interface with input from the 45 WS that allows forecasters to visualize the climatological frequencies of the timing of the first lightning strike. This tool should contribute directly to the 45 WS goal of improving lightning timing capability for its NASA, US Air Force and commercial customers.

Astronaut Bruce McCandless tests astronaut maneuvering unit

NASA Image and Video Library

1973-08-16

S72-30704 (1972) --- Astronaut Bruce McCandless II, backup pilot for Skylab 2, tests the balance and control of an astronaut maneuvering unit (AMU) test model at Martin Marietta Corporation's Denver division. The jet-powered backpack can fly for 30 minutes and can be worn over normal clothing or spacesuit. Photo credit: NASA

Quantifying Preferences of Farmers and Veterinarians for National Animal Health Programs: The Example of Bovine Mastitis and Antimicrobial Usage in Switzerland

PubMed Central

van den Borne, Bart H. P.; van Soest, Felix J. S.; Reist, Martin; Hogeveen, Henk

2017-01-01

Bovine udder health in Switzerland is of a relatively high level. However, antimicrobial usage (AMU) seems high in comparison to other European countries also. A new udder health and AMU improvement program could improve this situation but it is uncertain whether there is support from the field. This study aimed to quantify preferences of dairy farmers and veterinarians for the start and design characteristics of a new national udder health and AMU improvement program in Switzerland. A total of 478 dairy farmers and 98 veterinarians completed an online questionnaire. Questions on their demographics and their mindset toward AMU were complemented with an adaptive choice-based conjoint interview, a novel conjoint analysis technique to quantify preferences of respondents for characteristics of a product for which multiple trade-off decisions must be made (here a bovine udder health and AMU improvement program). The conjoint analysis was followed by a multivariate multiple regression analysis to identify groups of respondents with different program design preferences. Logistic regression models were used to associate covariates with respondents’ preference to start a new udder health and AMU improvement program. Most farmers (55%) and veterinarians (62%) were in favor of starting a new voluntary udder health and AMU improvement program, but the program design preferences agreed moderately between the two stakeholder groups. Farmers preferred an udder health and AMU improvement program that did not contain a penalty system for high AMU, was voluntary for all dairy herds, and aimed to simultaneously improve udder health and reduce AMU. Veterinarians preferred a program that had the veterinary organization and the government taking the lead in program design decision making, did not contain a penalty system for high AMU, and aimed to simultaneously improve udder health and reduce AMU. Differences between groups of farmers and veterinarians concerning their start preference were identified. Also, the magnitude of various program design preferences changed for farmers with different opinions toward AMU. The information obtained from this study may support the decision-making process and the communication to the field afterward, when discussing national strategies to improve udder health and AMU in Switzerland. PMID:28626750

Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-14

NASA Technical Reports Server (NTRS)

Bauman, William H.; Crawford, Winifred C.; Watson, Leela R.; Shafer, Jaclyn

2014-01-01

Ms. Crawford completed the final report for the dual-Doppler wind field task. Dr. Bauman completed transitioning the 915-MHz and 50-MHz Doppler Radar Wind Profiler (DRWP) splicing algorithm developed at Marshall Space Flight Center (MSFC) into the AMU Upper Winds Tool. Dr. Watson completed work to assimilate data into model configurations for Wallops Flight Facility (WFF) and Kennedy Space Center/Cape Canaveral Air Force Station (KSC/CCAFS). Ms. Shafer began evaluating the a local high-resolution model she had set up previously for its ability to forecast weather elements that affect launches at KSC/CCAFS. Dr. Watson began a task to optimize the data-assimilated model she just developed to run in real time.

Range-Specific High-resolution Mesoscale Model Setup

NASA Technical Reports Server (NTRS)

Watson, Leela R.

2013-01-01

This report summarizes the findings from an AMU task to determine the best model configuration for operational use at the ER and WFF to best predict winds, precipitation, and temperature. The AMU ran test cases in the warm and cool seasons at the ER and for the spring and fall seasons at WFF. For both the ER and WFF, the ARW core outperformed the NMM core. Results for the ER indicate that the Lin microphysical scheme and the YSU PBL scheme is the optimal model configuration for the ER. It consistently produced the best surface and upper air forecasts, while performing fairly well for the precipitation forecasts. Both the Ferrier and Lin microphysical schemes in combination with the YSU PBL scheme performed well for WFF in the spring and fall seasons. The AMU has been tasked with a follow-on modeling effort to recommended local DA and numerical forecast model design optimized for both the ER and WFF to support space launch activities. The AMU will determine the best software and type of assimilation to use, as well as determine the best grid resolution for the initialization based on spatial and temporal availability of data and the wall clock run-time of the initialization. The AMU will transition from the WRF EMS to NU-WRF, a NASA-specific version of the WRF that takes advantage of unique NASA software and datasets. 37

Development of diagnostics in the search for an explanation of aerotoxic syndrome.

PubMed

Schopfer, Lawrence M; Furlong, Clement E; Lockridge, Oksana

2010-09-01

Aerotoxic syndrome is assumed to be caused by exposure to tricresyl phosphate, an additive in engine lubricants and hydraulic fluids that is activated to the toxic 2-(ortho-cresyl)-4H-1,3,2-benzodioxaphosphoran-2-one (CBDP). Currently, there is no laboratory evidence to support intoxication of airline crew members by CBDP. Our goal was to develop methods for testing in vivo exposure by identifying and characterizing biomarkers. Mass spectrometry was used to study the reaction of CBDP with human albumin, free tyrosine, and human butyrylcholinesterase. Human albumin made a covalent bond with CBDP, adding a mass of 170amu to Tyr411 to yield the o-cresyl phosphotyrosine derivative. Human butyrylcholinesterase made a covalent bond with CBDP on Ser198 to yield five adducts with added masses of 80, 108, 156, 170, and 186amu. The most abundant adduct had an added mass of 80amu from phosphate (HPO(3)), a surprising result given that no pesticide or nerve agent is known to yield phosphorylated serine with an added mass of 80amu. The next most abundant adduct had an added mass of 170amu to form o-cresyl phosphoserine. It is concluded that toxic gases or oil mists in cabin air may form adducts on plasma butyrylcholinesterase and albumin, detectable by mass spectrometry. 2010 Elsevier Inc. All rights reserved.

Peak Wind Tool for General Forecasting

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III; Short, David

2008-01-01

This report describes work done by the Applied Meteorology Unit (AMU) in predicting peak winds at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). The 45th Weather Squadron requested the AMU develop a tool to help them forecast the speed and timing of the daily peak and average wind, from the surface to 300 ft on KSC/CCAFS during the cool season. Based on observations from the KSC/CCAFS wind tower network , Shuttle Landing Facility (SLF) surface observations, and CCAFS sounding s from the cool season months of October 2002 to February 2007, the AMU created mul tiple linear regression equations to predict the timing and speed of the daily peak wind speed, as well as the background average wind speed. Several possible predictors were evaluated, including persistence , the temperature inversion depth and strength, wind speed at the top of the inversion, wind gust factor (ratio of peak wind speed to average wind speed), synoptic weather pattern, occurrence of precipitation at the SLF, and strongest wind in the lowest 3000 ft, 4000 ft, or 5000 ft.

Use and clinical efficacy of standard and health information technology fall risk assessment tools.

PubMed

Teh, Ruth C; Wilson, Anne; Ranasinghe, Damith; Visvanathan, Renuka

2017-12-01

To evaluate the health information technology (HIT) compared to Fall Risk for Older Persons (FROP) tool in fall risk screening. A HIT tool trial was conducted on the geriatric evaluation and management (GEM, n = 111) and acute medical units (AMU, n = 424). Health information technology and FROP scores were higher on GEM versus AMU, with no differences between people who fell and people who did not fall. Both score completion rates were similar, and their values correlated marginally (Spearman's correlation coefficient 0.33, P < 0.01). HIT and FROP scores demonstrated similar sensitivity (80 vs 82%) and specificity (32 vs 36%) for detecting hospital falls. Hospital fall rates trended towards reduction on AMU (4.20 vs 6.96, P = 0.15) and increase on GEM (10.98 vs 6.52, P = 0.54) with HIT tool implementation. Health information technology tool acceptability and scoring were comparable to FROP screening, with mixed effects on fall rate with HIT tool implementation. Clinician partnership remains key to effective tool development. © 2017 AJA Inc.

Configuring the HYSPLIT Model for National Weather Service Forecast Office and Spaceflight Meteorology Group Applications

NASA Technical Reports Server (NTRS)

Dreher, Joseph G.

2009-01-01

For expedience in delivering dispersion guidance in the diversity of operational situations, National Weather Service Melbourne (MLB) and Spaceflight Meteorology Group (SMG) are becoming increasingly reliant on the PC-based version of the HYSPLIT model run through a graphical user interface (GUI). While the GUI offers unique advantages when compared to traditional methods, it is difficult for forecasters to run and manage in an operational environment. To alleviate the difficulty in providing scheduled real-time trajectory and concentration guidance, the Applied Meteorology Unit (AMU) configured a Linux version of the Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) (HYSPLIT) model that ingests the National Centers for Environmental Prediction (NCEP) guidance, such as the North American Mesoscale (NAM) and the Rapid Update Cycle (RUC) models. The AMU configured the HYSPLIT system to automatically download the NCEP model products, convert the meteorological grids into HYSPLIT binary format, run the model from several pre-selected latitude/longitude sites, and post-process the data to create output graphics. In addition, the AMU configured several software programs to convert local Weather Research and Forecast (WRF) model output into HYSPLIT format.

Situational Lightning Climatologies for Central Florida: Phase V

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2011-01-01

The AMU added three years of data to the POR from the previous work resulting in a 22-year POR for the warm season months from 1989-2010. In addition to the flow regime stratification, moisture and stability stratifications were added to separate more active from less active lighting days within the same flow regime. The parameters used for moisture and stability stratifications were PWAT and TI which were derived from sounding data at four Florida radiosonde sites. Lightning data consisted of NLDN CG lightning flashes within 30 NM of each airfield. The AMU increased the number of airfields from nine to thirty-six which included the SLF, CCAFS, PAFB and thirty-three airfields across Florida. The NWS MLB requested the AMU calculate lightning climatologies for additional airfields that they support as a backup to NWS TBW which was then expanded to include airfields supported by NWS JAX and NWS MFL. The updated climatologies of lightning probabilities are based on revised synoptic-scale flow regimes over the Florida peninsula (Lambert 2007) for 5-, 10-, 20- and 30-NM radius range rings around the thirty-six airfields in 1-, 3- and 6-hour increments. The lightning, flow regime, moisture and stability data were processed in S-PLUS software using scripts written by the AMU to automate much of the data processing. The S-PLUS data files were exported to Excel to allow the files to be combined in Excel Workbooks for easier data handling and to create the tables and charts for the Gill. The AMU revised the Gill developed in the previous phase (Bauman 2009) with the new data and provided users with an updated HTML tool to display and manipulate the data and corresponding charts. The tool can be used with most web browsers and is computer operating system independent. The AMU delivered two Gills - one with just the PWAT stratification and one with both the PWAT and TI stratifications due to insufficient data in some of the PWATITI stratification combinations. This will allow the forecasters to choose a moisture-only or moisture/stability stratification depending on the flow regime and available data.

Determining the Probability of Violating Upper-Level Wind Constraints for the Launch of Minuteman III Ballistic Missiles at Vandenberg Air Force Base

NASA Technical Reports Server (NTRS)

Shafer, Jaclyn A.; Brock, Tyler M.

2012-01-01

The 30th Operational Support Squadron Weather Flight (30 OSSWF) provides comprehensive weather services to the space program at Vandenberg Air Force Base (VAFB) in California. One of their responsibilities is to monitor upper-level winds to ensure safe launch operations of the Minuteman Ill ballistic missile. The 30 OSSWF tasked the Applied Meteorology Unit (AMU) to analyze VAFB sounding data with the goal of determining the probability of violating (PoV) their upper-level thresholds for wind speed and shear constraints specific to this launch vehicle, and to develop a tool that will calculate the PoV of each constraint on the day of launch. In order to calculate the probability of exceeding each constraint, the AMU collected and analyzed historical data from VAFB. The historical sounding data were retrieved from the National Oceanic and Atmospheric Administration Earth System Research Laboratory archive for the years 1994-2011 and then stratified into four sub-seasons: January-March, April-June, July-September, and October-December. The AMU determined the theoretical distributions that best fit the maximum wind speed and maximum wind shear datasets and applied this information when calculating the averages and standard deviations needed for the historical and real-time PoV calculations. In addition, the AMU included forecast sounding data from the Rapid Refresh model. This information provides further insight for the launch weather officers (LWOs) when determining if a wind constraint violation will occur over the next few hours on the day of launch. The AMU developed an interactive graphical user interface (GUI) in Microsoft Excel using Visual Basic for Applications. The GUI displays the critical sounding data easily and quickly for LWOs on day of launch. This tool will replace the existing one used by the 30 OSSWF, assist the LWOs in determining the probability of exceeding specific wind threshold values, and help to improve the overall upper winds forecast for the launch customer. This presentation will describe how the AMU calculated the historical and real-time PoV values for the specific upper-level wind launch constraints and outline the development of the interactive GUI display.

Anvil Forecast Tool in the Advanced Weather Interactive Processing System

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III; Hood, Doris

2009-01-01

Meteorologists from the 45th Weather Squadron (45 WS) and National Weather Service Spaceflight Meteorology Group (SMG) have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violations of the Lightning Launch Commit Criteria and Space Shuttle Flight Rules. As a result, the Applied Meteorology Unit (AMU) was tasked to create a graphical overlay tool for the Meteorological Interactive Data Display System (MIDDS) that indicates the threat of thunderstorm anvil clouds, using either observed or model forecast winds as input. The tool creates a graphic depicting the potential location of thunderstorm anvils one, two, and three hours into the future. The locations are based on the average of the upper level observed or forecasted winds. The graphic includes 10 and 20 n mi standoff circles centered at the location of interest, as well as one-, two-, and three-hour arcs in the upwind direction. The arcs extend outward across a 30 sector width based on a previous AMU study that determined thunderstorm anvils move in a direction plus or minus 15 of the upper-level wind direction. The AMU was then tasked to transition the tool to the Advanced Weather Interactive Processing System (AWIPS). SMG later requested the tool be updated to provide more flexibility and quicker access to model data. This presentation describes the work performed by the AMU to transition the tool into AWIPS, as well as the subsequent improvements made to the tool.

Applied Meteorology Unit (AMU)

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Wheeler, Mark

2011-01-01

This Quarter's Highlights incllude: completion of the second phase of verifying the performance of the MesoNAM weather model at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). (1) The data was delivered to the 45th Weather Squadron (45 WS) and the final report was distributed (2) Staff completed modifying and updating lightning c1imatologies for KSC/CCAFS and other airfields around central Florida. We delivered the tool to the National Weather Service in Melbourne and 45 WS and distributed the final report (3) Staff completed modifying the AMU peak wind tool by analyzing wind tower data to determine peak wind behavior during times of onshore and offshore flow. This was delivered the to the 45 WS and distributed the final report.

Higher perceived risk of antimicrobials is related to lower antimicrobial usage among pig farmers in four European countries.

PubMed

Visschers, V H M; Postma, M; Sjölund, M; Backhans, A; Collineau, L; Loesken, S; Belloc, C; Dewulf, J; Emanuelson, U; Grosse Beilage, E; Siegrist, M; Stärk, K D C

2016-11-12

The prudent use of antimicrobials (AMs) should be widened in pig farming to reduce the risk of AM resistance (AMR) in human and veterinary medicine. It is therefore important to understand pig farmers' motivators and the barriers to AM usage (AMU) on their farms. The authors investigated pig farmers' self-estimated levels of AMU, their perceived benefits and risks and the need for AMs in a cross-sectional survey in Belgium, France, Germany and Sweden. The authors also compared these perceptions between the four countries and related them to pig farmers' actual AMU. The results showed that farmers who used more AMs also estimated their own usage as higher. Farmers perceived many benefits but relatively few risks of AMU in pig farming. Some significant cross-country differences in farmers' perceptions were found, but they were relatively small. After controlling for country differences and farm differences, only perceived risks had a significant association with AMU. The authors therefore conclude that in order to promote prudent AMU, it seems most promising to focus on the structural differences in pig farming and veterinary medicine (e.g. legislation, role of the veterinarian) among countries. In addition, interventions which aim at reducing AMU should increase farmers' awareness of the risks of extensive AMU. British Veterinary Association.

A measurement of the energy spectra of cosmic rays from 20 to 1000 GeV per amu

NASA Technical Reports Server (NTRS)

Gregory, John C.; Takahashi, Y.; Hayashi, T.; Thoburn, C.; Parnell, T. A.; Watts, John W., Jr.; Fowler, P. H.; Masheder, M. R. W.; Derrickson, James H.

1991-01-01

A group collaboration was made in the development of the Bristol University Gas Spectrometer number 4 (BUGS 4). The BUGS 4 detector is designed to measure the charge spectrum for species between oxygen and the iron peak as a function of energy per nucleon, between 20 and 1000 GeV/amu. It is particularly concerned with energies above 50 GeV/amu. The high energy component is considerably less affected by propagation through the interstellar medium than the lower energy component and is expected to approach the original charge spectrum of the source more closely. This information allows one to unravel the effects of cosmic ray production, acceleration, and propagation. The detector is described in total detail. The method of estimating the charge and energy of a cosmic ray depends on the energy of the particle. Calculations and experiments lead to the expectation of a nearly constant charge resolution of about 0.2 charge units over the whole energy range except 4.5 less than gamma less than 20. In this band, the experiment is insensitive to energy. A balloon flight is planned in 1993.

Ammonia in comet P/Halley

NASA Technical Reports Server (NTRS)

Meier, R.; Eberhardt, P.; Krankowsky, D.; Hodges, R. R.

1994-01-01

In comet P/Halley the abundances of ammonia relative to water reported in the literature differ by about one order of magnitude from roughly 0.1% up to 2%. Different observational techniques seem to have inherent systematic errors. Using the ion mass channels m/q = 19 amu/e, 18 amu/e and 17 amu/e of the Neutral Mass Spectrometer experiment aboard the spacecraft Giotto, we derive a production rate of ammonia of (1.5(sub -0.7)(sup +0.5))% relative to water. Inside the contact surface we can explain our data by a nuclear source only. The uncertainty in our abundance of ammonia is primarily a result of uncertainties in some key reaction coefficients. We discuss in detail these reactions and the range of error indicated results from extreme assumptions in the rate coefficients. From our data, even in the worst case, we can exclude the ammonia abundance to be only of the order of a few per mill.

Midwives' experiences of labour care in midwifery units. A qualitative interview study in a Norwegian setting.

PubMed

Skogheim, Gry; Hanssen, Tove A

2015-12-01

In some economically developed countries, women's choice of birth care and birth place is encouraged. The aim of this study was to explore and describe the experiences of midwives who started working in alongside/free-standing midwifery units (AMU/FMU) and their experiences with labour care in this setting. A qualitative explorative design using a phenomenographic approach was used. Semi-structured interviews were conducted with ten strategically sampled midwives working in midwifery units. The analysis revealed the following five categories of experiences noted by the midwives: mixed emotions and de-learning obstetric unit habits, revitalising midwifery philosophy, alertness and preparedness, presence and patience, and coping with time. Starting to work in an AMU/FMU can be a distressing period for a midwife. First, it may require de-learning the medical approach to birth, and, second, it may entail a revitalisation (and re-learning) of birth care that promotes physiological birth. Midwifery, particularly in FMUs, requires an especially careful assessment of the labouring process, the ability to be foresighted, and capability in emergencies. The autonomy of midwives may be constrained also in AMUs/FMUs. However, working in these settings is also viewed as experiencing "the art of midwifery" and enables revitalisation of the midwifery philosophy. Copyright © 2015 Elsevier B.V. All rights reserved.

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name English common name Scientific name Amu piniki-mumu Pink coral (also known...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name English common name Scientific name Amu piniki-mumu Pink coral (also known...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name Englishcommon name Scientific name Amu piniki-mumu Pink coral (also known as...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name Englishcommon name Scientific name Amu piniki-mumu Pink coral (also known as...

50 CFR 665.161 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Definitions. As used in §§ 665.160 through 665.169: American Samoa precious coral management unit species (American Samoa precious coral MUS) means any coral of the genus Corallium in addition to the following species of corals: Local name Englishcommon name Scientific name Amu piniki-mumu Pink coral (also known as...

Farmers' knowledge and expectations of antimicrobial use and resistance are strongly related to usage in Dutch livestock sectors.

PubMed

Kramer, Tineke; Jansen, Leonie E; Lipman, Len J A; Smit, Lidwien A M; Heederik, Dick J J; Dorado-García, Alejandro

2017-11-01

Comprehensive strategies to improve on-farm antimicrobial use (AMU) are needed to contain antimicrobial resistance (AMR). Little is known about farmers' motivating and enabling factors, and about their influence on AMU. In a cross-sectional online survey, Dutch dairy, veal and pig farmers (n=457) reported their on-farm AMU as "Defined Daily Dose Animal" per year (DDDA F ) and completed a detailed questionnaire on their view, knowledge and behavior towards AMU and AMR. Exploratory factor analysis (EFA) on the questionnaire items identified four psychological factors labeled as 'referent beliefs', 'perceived risk', 'knowledge', and 'undesired attitude to regulations'. Linear regression was done to explore the relationship between the obtained factors and on-farm AMU across the three animal sectors. Dairy farmers showed the highest factor scores for 'knowledge' and the lowest for 'perceived risk'. 'Knowledge' scores were significantly and inversely related to AMU (P=0.0004). Borderline significant associations with AMU were found for 'perceived risk' and 'undesired attitude to regulations' (negative and positive relationships respectively). There were no apparent differences for these relationships between the three livestock sectors. Behavioral interventions in farmers such as educational campaigns or increased support by veterinarians could empower farmers with more prudent and rational practices, eventually reducing AMU in food animals. Copyright © 2017 Elsevier B.V. All rights reserved.

Applied Meteorology Unit Quarterly Report. First Quarter FY-13

NASA Technical Reports Server (NTRS)

2013-01-01

The AMU team worked on five tasks for their customers: (1) Ms. Crawford continued work on the objective lightning forecast task for airports in east-central Florida. (2) Ms. Shafer continued work on the task for Vandenberg Air Force Base to create an automated tool that will help forecasters relate pressure gradients to peak wind values. (3) Dr. Huddleston began work to develop a lightning timing forecast tool for the Kennedy Space Center/Cape Canaveral Air Force Station area. (3) Dr. Bauman began work on a severe weather forecast tool focused on east-central Florida. (4) Dr. Watson completed testing high-resolution model configurations for Wallops Flight Facility and the Eastern Range, and wrote the final report containing the AMU's recommendations for model configurations at both ranges.

The farm cost of decreasing antimicrobial use in dairy production

PubMed Central

Tauer, Loren William; Gröhn, Yrjo Tapio

2018-01-01

Antimicrobials are used in animal agriculture to cure bacterial infectious diseases. However, antimicrobial use (AMU) inevitably leads to the selection of resistant bacteria, potentially infecting humans. As a global public threat, antimicrobial resistance has led policy makers to implement regulations supervising AMU. The objective of our research was to investigate the farm impact of several potential policies aimed at decreasing AMU. We modeled a dairy herd of 1000 cows with an average level of disease prevalence for the nine most frequent bacterial dairy diseases found in western countries. We calculated the farm net costs of AMU prohibition, as well as cost increases in antimicrobial treatments prices, and an increase in the milk withdrawal period after AMU. Sensitivity analyses were conducted to assess the impact of output and input prices, and disease prevalence. At a mean disease prevalence, the average net costs of not using antimicrobials were $61 per cow per year greater compared to a scenario modeling current farm AMU. The model predicted that the minimum and maximum increased costs associated with AMU prohibition were $46 and $73 per cow per year compared to current AMU. In each scenario, the cost difference increased with disease prevalence. Sensitivity analysis showed that the three stochastic variables which most significantly influenced the cost difference were respectively, cow replacement prices, cow slaughter price, and the milk price. Antimicrobial price increases of a factor of five, or extending the milk withdrawal period by 15 days, resulted in increasing the costs of diseases to a level where the farmer was better off not using antimicrobials. Our results suggest that the farm level costs of AMU prohibition in many cases might be minor, although the consequences of any policy instrument should be carefully evaluated to reach the ultimate goal of decreasing AMU without threatening the sustainability of milk production. PMID:29566103

Configuration and Evaluation of a Dual-Doppler 3-D Wind Field System

NASA Technical Reports Server (NTRS)

Crawford, Winifred C.

2014-01-01

Current LSP, GSDO, and SLS space vehicle operations are halted when wind speeds from specific directions exceed defined thresholds and when lightning is a threat. Strong winds and lightning are difficult parameters for the 45th Weather Squadron (45 WS) to forecast, yet are important in the protection of customer vehicle operations and the personnel that conduct them. A display of the low-level horizontal wind field to reveal areas of high winds or convergence would be a valuable tool for forecasters in assessing the timing of high winds, or convection initiation and subsequent lightning occurrence. This is especially important for areas where no weather observation platforms exist. Developing a dual-Doppler radar capability would provide such a display to assist forecasters in predicting high winds and convection initiation. The wind fields can also be used to initialize a local mesoscale numerical weather prediction model to help improve the model forecast winds, convection initiation, and other phenomena. The 45 WS and NWS MLB tasked the Applied Meteorology Unit (AMU) to develop a dual- Doppler wind field display using data from the 45th Space Wing radar, known as the Weather Surveillance Radar (WSR), NWS MLB Weather Surveillance Radar 1988 Doppler (KMLB), and the Orlando International Airport Terminal Doppler Weather Radar (KMCO). They also stipulated that the software used should be freely available. The AMU evaluated two software packages and, with concurrence from NWS MLB and the 45 WS, chose the Warning Decision Support System-Integrated Information (WDSS-II). The AMU collected data from two significant weather cases: a tornadic event on 14 April 2013 and a severe wind and hail event on 12 February 2014. For the 14 April case, the data were from WSR and KMLB. For the 12 February case, the data were from KMCO and KMLB. The AMU installed WDSS-II on a Linux PC, then processed and quality controlled the radar data for display and analysis using WDSS-II tools. Because of issues with de-aliasing the WSR velocity field, the AMU did not use data from this radar in this study and only analyzed the 12 February case. Merging the data to create the dual-Doppler analysis involved several steps. The AMU used instructions from the WDSS-II website and discussion forum to determine the correct tools to use for the analysis, and was successful in creating a merged reflectivity field, which was critical to the success of creating a merged velocity field. However, the AMU was unable to create a merged velocity field. The AMU researched the WDSS-II forum for discussions on similar issues, asked questions on the forum, and tested different options and values in the merger tool with no success. Developing a dual-Doppler wind field was the main goal of this task, but that was not accomplished. It could be an issue of not using the correct options or the correct value for the options used, or there could be issues with the radar data. There is a follow-on AMU task to install the operational version of WDSS-II in the NWS MLB office. This will provide more opportunities to try different options and input values in order to create a merged wind field from KMCO and KMLB.

Improving Maintenance Data Collection Via Point-of- Maintenance (POMX) Implementation

DTIC Science & Technology

2006-03-01

accurate documentation, (3) identifying and correcting the root causes for poor data integrity, and (4) educating the unit on the critical need for data ...the validity of the results. The data in this study were analyzed using the SAS JMP 6.0 statistical software package. The results for the tests...traditional keyboard data entry methods at a computer terminal. These terminals are typically located in the aircraft maintenance unit (AMU) facility , away

Improving Maintenance Data Collection Via Point-Of-Maintenance (POMX) Implementation

DTIC Science & Technology

2006-03-01

accurate documentation, (3) identifying and correcting the root causes for poor data integrity, and (4) educating the unit on the critical need for data ...the validity of the results. The data in this study were analyzed using the SAS JMP 6.0 statistical software package. The results for the tests...traditional keyboard data entry methods at a computer terminal. These terminals are typically located in the aircraft maintenance unit (AMU) facility , away

Users Guide for the Anvil Threat Corridor Forecast Tool V1.7.0 for AWIPS

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2007-01-01

The Applied Meteorology Unit (AMU) originally developed the Anvil Threat Sector Tool for the Meteorological Interactive Data Display System (MIDDS) and delivered the capability in three phases beginning with a feasibility study in 2000 and delivering the operational final product in December 2003. This tool is currently used operationally by the 45th Weather Squadron (45 WS) Launch Weather Officers (LWO) and Spaceflight Meteorology Group (SMG) forecasters. Phase I of the task established the technical feasibility of developing an objective, observations-based tool for short-range anvil forecasting. The AMU was subsequently tasked to develop short-term anvil forecasting tools to improve predictions of the threat of triggered lightning to space launch and landing vehicles. Under the Phase II effort, the AMU developed a nowcasting anvil threat sector tool, which provided the user with a threat sector based on the most current radiosonde upper wind data from a co-located or upstream station. The Phase II Anvil Threat Sector Tool computes the average wind speed and direction in the layer between 300 and 150 mb from the latest radiosonde for a user-designated station. The following threat sector properties are consistent with the propagation and lifetime characteristics of thunderstorm anvil clouds observed over Florida and its coastal waters (Short et al. 2002): a) 20 n mi standoff circle, b) 30 degree sector width, c) Orientation given by 300 to 150 mb average wind direction, d) 1-, 2-, and 3- hour arcs in upwind direction, and e) Arc distances given by 300 to 150 mb average wind speed. Figure 1 is an example of the MIDDS Anvil Threat Sector tool overlaid on a visible satellite image at 2132 UTC 13 May 2001. Space Launch Complex 39A was selected as the center point and the Anvil Threat Sector was determined from upper-level wind data at 1500 UTC in the preconvective environment. Narrow thunderstorm anvil clouds extend from central Florida to the space launch and landing facilities at the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) and beyond. The anvil clouds were generated around 1930 UTC (1430 EDT) by thunderstorm activity over central Florida and transported 90 n mi east-northeastward within 2 hours, as diagnosed by the anvil forecast tool. Phase III, delivered in February 2003, built upon the results of Phase II by enhancing the Anvil Threat Sector Tool with the capability to use national model forecast winds for depiction of potential anvil lengths and orientations over the KSC/CCAFS area with lead times from 3 through 168 hours (7 days). In September 2003, AMU customers requested the capability to use data from the KSC 50 MHz Doppler Radar Wind Profiler (DRWP) in the Anvil Threat Sector Tool and this capability was delivered by the AMU in December 2003. In March 2005, the AMU was tasked to migrate the MIDDS Anvil Threat Sector Tool capabilities onto the Advanced Weather Interactive Processing System (AWIPS) as the Anvil Threat Corridor Forecast Tool.

A proposed analytic framework for determining the impact of an antimicrobial resistance intervention.

PubMed

Grohn, Yrjo T; Carson, Carolee; Lanzas, Cristina; Pullum, Laura; Stanhope, Michael; Volkova, Victoriya

2017-06-01

Antimicrobial use (AMU) is increasingly threatened by antimicrobial resistance (AMR). The FDA is implementing risk mitigation measures promoting prudent AMU in food animals. Their evaluation is crucial: the AMU/AMR relationship is complex; a suitable framework to analyze interventions is unavailable. Systems science analysis, depicting variables and their associations, would help integrate mathematics/epidemiology to evaluate the relationship. This would identify informative data and models to evaluate interventions. This National Institute for Mathematical and Biological Synthesis AMR Working Group's report proposes a system framework to address the methodological gap linking livestock AMU and AMR in foodborne bacteria. It could evaluate how AMU (and interventions) impact AMR. We will evaluate pharmacokinetic/dynamic modeling techniques for projecting AMR selection pressure on enteric bacteria. We study two methods to model phenotypic AMR changes in bacteria in the food supply and evolutionary genotypic analyses determining molecular changes in phenotypic AMR. Systems science analysis integrates the methods, showing how resistance in the food supply is explained by AMU and concurrent factors influencing the whole system. This process is updated with data and techniques to improve prediction and inform improvements for AMU/AMR surveillance. Our proposed framework reflects both the AMR system's complexity, and desire for simple, reliable conclusions.

Radar Scan Strategies for the Patrick Air Force Base Weather Surveillance Radar, Model-74C, Replacement

NASA Technical Reports Server (NTRS)

Short, David

2008-01-01

The 45th Weather Squadron (45 WS) is replacing the Weather Surveillance Radar, Model 74C (WSR-74C) at Patrick Air Force Base (PAFB), with a Doppler, dual polarization radar, the Radtec 43/250. A new scan strategy is needed for the Radtec 43/250, to provide high vertical resolution data over the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) launch pads, while taking advantage of the new radar's advanced capabilities for detecting severe weather phenomena associated with convection within the 45 WS area of responsibility. The Applied Meteorology Unit (AMU) developed several scan strategies customized for the operational needs of the 45 WS. The AMU also developed a plan for evaluating the scan strategies in the period prior to operational acceptance, currently scheduled for November 2008.

Cosmic-ray energy spectra between 10 and several hundred GeV per atomic mass unit for elements from Ar-18 to Ni-28 - Results from HEAO 3

NASA Technical Reports Server (NTRS)

Binns, W. R.; Israel, M. H.; Jones, Michael D.; Kamionkowski, M. P.; Garrard, T. L.

1988-01-01

Results from the Heavy Nuclei experiment on HEAO 3 are used to determine the primary abundances of Ni and Fe. Ni and Fe are found to have nearly constant relative abundances over the interval of 10 to about 500 GeV per amu. Individual secondary elements derived principally from interactions of primary Fe nuclei are shown to display a power-law decrease in relative abundance up to about 150 GeV per amu. Ar/Fe and Ca/Fe ratios of 2.6 + or - 0.7 percent and 8.8 + or - 0.7 percent, respectively, are found, confirming a fractionation of source abundances in which elements with high values of the first ionization potential are depleted relative to those with low first ionization potential.

Simulation of a Real-Time Local Data Integration System over East-Central Florida

NASA Technical Reports Server (NTRS)

Case, Jonathan

1999-01-01

The Applied Meteorology Unit (AMU) simulated a real-time configuration of a Local Data Integration System (LDIS) using data from 15-28 February 1999. The objectives were to assess the utility of a simulated real-time LDIS, evaluate and extrapolate system performance to identify the hardware necessary to run a real-time LDIS, and determine the sensitivities of LDIS. The ultimate goal for running LDIS is to generate analysis products that enhance short-range (less than 6 h) weather forecasts issued in support of the 45th Weather Squadron, Spaceflight Meteorology Group, and Melbourne National Weather Service operational requirements. The simulation used the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS) software on an IBM RS/6000 workstation with a 67-MHz processor. This configuration ran in real-time, but not sufficiently fast for operational requirements. Thus, the AMU recommends a workstation with a 200-MHz processor and 512 megabytes of memory to run the AMU's configuration of LDIS in real-time. This report presents results from two case studies and several data sensitivity experiments. ADAS demonstrates utility through its ability to depict high-resolution cloud and wind features in a variety of weather situations. The sensitivity experiments illustrate the influence of disparate data on the resulting ADAS analyses.

The Evaluation of the Regional Atmospheric Modeling System in the Eastern Range Dispersion Assessment System

NASA Technical Reports Server (NTRS)

Case, Jonathan

2001-01-01

The Applied Meteorology Unit (AMU) evaluated the Regional Atmospheric Modeling System (RAMS) contained within the Eastern Range Dispersion Assessment System (ERDAS). ERDAS provides emergency response guidance for Cape Canaveral Air Force Station and Kennedy Space Center operations in the event of an accidental hazardous material release or aborted vehicle launch. The RAMS prognostic data are available to ERDAS for display and are used to initialize the 45th Space Wing/Range Safety dispersion model. Thus, the accuracy of the dispersion predictions is dependent upon the accuracy of RAMS forecasts. The RAMS evaluation consisted of an objective and subjective component for the 1999 and 2000 Florida warm seasons, and the 1999-2000 cool season. In the objective evaluation, the AMU generated model error statistics at surface and upper-level observational sites, compared RAMS errors to a coarser RAMS grid configuration, and benchmarked RAMS against the nationally-used Eta model. In the subjective evaluation, the AMU compared forecast cold fronts, low-level temperature inversions, and precipitation to observations during the 1999-2000 cool season, verified the development of the RAMS forecast east coast sea breeze during both warm seasons, and examined the RAMS daily thunderstorm initiation and precipitation patterns during the 2000 warm season. This report summarizes the objective and subjective verification for all three seasons.

Mutagenesis in human cells with accelerated H and Fe ions

NASA Technical Reports Server (NTRS)

Kronenberg, Amy

1994-01-01

The overall goals of this research were to determine the risks of mutation induction and the spectra of mutations induced by energetic protons and iron ions at two loci in human lymphoid cells. During the three year grant period the research has focused in three major areas: (1) the acquisition of sufficient statistics for human TK6 cell mutation experiments using Fe ions (400 MeV/amu), Fe ions (600 MeV/amu) and protons (250 MeV/amu); (2) collection of thymidine kinase- deficient (tk) mutants or hypoxanthine phosphoribosyltransferase deficient (hprt) mutants induced by either Fe 400 MeV/amu, Fe 600 MeV/amu, or H 250 MeV/amu for subsequent molecular analysis; and (3) molecular characterization of mutants isolated after exposure to Fe ions (600 MeV/amu). As a result of the shutdown of the BEVALAC heavy ion accelerator in December 1992, efforts were rearranged somewhat in time to complete our dose-response studies and to complete mutant collections in particular for the Fe ion beams prior to the shutdown. These goals have been achieved. A major effort was placed on collection, re-screening, and archiving of 3 different series of mutants for the various particle beam exposures: tk-ng mutants, tk-sg mutants, and hprt-deficient mutants. Where possible, groups of mutants were isolated for several particle fluences. Comparative analysis of mutation spectra has occured with characterization of the mutation spectrum for hprt-deficient mutants obtained after exposure of TK6 cells to Fe ions (600 MeV/amu) and a series of spontaneous mutants.

Performance evaluation of a miniature magnetic sector mass spectrometer onboard a satellite in space.

PubMed

Guo, Meiru; Li, Detian; Cheng, Yongjun; Wang, Yongjun; Sun, Wenjun; Pei, Xiaoqiang; Dong, Meng; Sheng, Xuemin; Zhao, Lan; Li, Yanwu

2018-04-01

With the rapid development of space technology in China, it is urgent to use mass spectrometer to detect the space environment. In this work, a space miniature magnetic sector mass spectrometer is evaluated, which consists of three subsystems: (1) physical unit, (2) electric control unit, (3) and high voltage power. It has 90° magnetic sector-field analyzer with double trajectory, in which a trajectory measurement range is from 1 to 12 amu, the other range is from 6 to 90 amu.The mass spectrometer has two work models, one is used to measure space neutral gas when the filament of mass spectrometer ion source turned on, the other is used to measure space charged ions when the filament turned off. The absolute resolution of this device is less than 1 amu, the minimum detectable ion current is about 10 -13  A, and the sensitivity is 10 -6  A/Pa (N 2 ). Its overall size is 170 mm × 165 mm × 170 mm, its weight is 4.5 kg, and its power consumption is 18 W. A series of environmental adaptability tests, including high and low temperature cycle, shock, vibration, thermal vacuum cycle, were carried out on the ground before launching, and sensitivity and peak position were also calibrated on the ground. In November 2012, the mass spectrometer was carried by an experimental satellite to 499 km sun synchronization and is still working right now. It successfully detected the atmosphere compositions both in the satellite orbit and gas-emitted from satellite, including O, He, 12 CO 2 , 13 CO 2 , H 2 , N 2 , O 2 , H 2 O, and so on.

Estimating neutron dose equivalent rates from heavy ion reactions around 10 MeV amu(-1) using the PHITS code.

PubMed

Iwamoto, Yosuke; Ronningen, R M; Niita, Koji

2010-04-01

It has been sometimes necessary for personnel to work in areas where low-energy heavy ions interact with targets or with beam transport equipment and thereby produce significant levels of radiation. Methods to predict doses and to assist shielding design are desirable. The Particle and Heavy Ion Transport code System (PHITS) has been typically used to predict radiation levels around high-energy (above 100 MeV amu(-1)) heavy ion accelerator facilities. However, predictions by PHITS of radiation levels around low-energy (around 10 MeV amu(-1)) heavy ion facilities to our knowledge have not yet been investigated. The influence of the "switching time" in PHITS calculations of low-energy heavy ion reactions, defined as the time when the JAERI Quantum Molecular Dynamics model (JQMD) calculation stops and the Generalized Evaporation Model (GEM) calculation begins, was studied using neutron energy spectra from 6.25 MeV amu(-1) and 10 MeV amu(-1) (12)C ions and 10 MeV amu(-1) (16)O ions incident on a copper target. Using a value of 100 fm c(-1) for the switching time, calculated neutron energy spectra obtained agree well with the experimental data. PHITS was then used with the switching time of 100 fm c(-1) to simulate an experimental study by Ohnesorge et al. by calculating neutron dose equivalent rates produced by 3 MeV amu(-1) to 16 MeV amu(-1) (12)C, (14)N, (16)O, and (20)Ne beams incident on iron, nickel and copper targets. The calculated neutron dose equivalent rates agree very well with the data and follow a general pattern which appears to be insensitive to the heavy ion species but is sensitive to the target material.

Vandenberg Air Force Base Pressure Gradient Wind Study

NASA Technical Reports Server (NTRS)

Shafer, Jaclyn A.

2013-01-01

Warning category winds can adversely impact day-to-day space lift operations at Vandenberg Air Force Base (VAFB) in California. NASA's Launch Services Program and other programs at VAFB use wind forecasts issued by the 30 Operational Support Squadron Weather Flight (30 OSSWF) to determine if they need to limit activities or protect property such as a launch vehicle. The 30 OSSWF tasked the AMU to develop an automated Excel graphical user interface that includes pressure gradient thresholds between specific observing stations under different synoptic regimes to aid forecasters when issuing wind warnings. This required the AMU to determine if relationships between the variables existed.

Modifications to the Objective Lightning Probability Forecast Tool at Kennedy Space Center/Cape Canaveral Air Force Station, Florida

NASA Technical Reports Server (NTRS)

Crawford, Winifred; Roeder, William

2010-01-01

The 45th Weather Squadron (45 WS) at Cape Canaveral Air Force Station (CCAFS) includes the probability of lightning occurrence in their 24-Hour and Weekly Planning Forecasts, briefed at 0700 EDT for daily operations planning on Kennedy Space Center (KSC) and CCAFS. This forecast is based on subjective analyses of model and observational data and output from an objective tool developed by the Applied Meteorology Unit (AMU). This tool was developed over two phases (Lambert and Wheeler 2005, Lambert 2007). It consists of five equations, one for each warm season month (May-Sep), that calculate the probability of lightning occurrence for the day and a graphical user interface (GUI) to display the output. The Phase I and II equations outperformed previous operational tools by a total of 56%. Based on this success, the 45 WS tasked the AMU with Phase III to improve the tool further.

Ammonia 15N/14N Isotope Ratio in the Jovian Atmosphere

NASA Technical Reports Server (NTRS)

Mahaffy, P.R.; Niemann, H. B.; Atreya, S. K.; Wong, M. H.; Owen, T. C; Einaudi, Franco (Technical Monitor)

2000-01-01

Data from the Galileo Probe Mass Spectrometer has been used to derive the N-15/N-14 isotope ratio in ammonia at Jupiter. Although the mass spectral interference from the water contribution to 18 amu makes an accurate derivation of the (N-15)H3/(N-14)H3 ratio difficult from measurements of the singly ionized signals at 18 and 17 amu, this interference is not present in the doubly charged 8.5 and 9.0 amu signals from (N-14)H3++ and (N-15)H3++ respectively. Although the count rate from the 9 amu signal is low during the direct sampling of the atmosphere, the ammonia signal was considerably enhanced during the first enrichment cell (EC1) experiment that measured gas sampled between 0.8 and 2.8 bar. Count rates at 9 amu in the EC1 experiment reach 60/second and measure ammonia sampled from 0.88 to 2.8 bar. In the EC1 measurements the 8.5 amu signal is not measured directly, but can be calculated from the ammonia contribution to 17 amu and the ratio of NH3 ions of a double to single charged observed during a high resolution mass scan taken near the end of the descent. The high resolution scan gives this ratio from ammonia sampled much deeper in the atmosphere. These results are described and compared with Infrared Space Observatory-Short Wavelength Spectrometer (ISO-SWS) observations that give this ratio at 400 mbar.

Survey of quantitative antimicrobial consumption in two different pig finishing systems.

PubMed

Moreno, M A

2012-09-29

The primary objectives of this study were to: (a) collect on-farm antimicrobial use (AMU) data in fattener pigs employing two questionnaire-based surveys; (b) assess different quantitative measures for quantifying AMU in fattener pigs; (c) compare AMU in fattener pigs between two different management systems producing finishers: farrow-to-finish (FtF) farms versus finisher farms. Two questionnaires were designed both containing five groups of questions focused on the responder, the farm and AMU (eg, in-feed, in-drinking water and parenteral); both surveys were carried out by means of personal face-to-face interviews. Both surveys started with a sample size of 108 potentially eligible farms per survey; nevertheless, finally 67 finisher farms and 49 FtF farms were recruited. Overall percentages of animals exposed to antimicrobials (AM) were high (90 per cent in finisher farms and 54 per cent FtF farms); colistin (61 per cent and 33 per cent) and doxycycline (62 per cent and 23 per cent) were the most common AMs, followed by amoxicillin (51 per cent and 19 per cent) and lincomycin (49 per cent), respectively. Questionnaire-based surveys using face-to-face interviews are useful for capturing information regarding AMU at the farm level. Farm-level data per administration route can be used for comparative AMU analysis between farms. Nevertheless, for the analysis of the putative relationships between AMU and AM resistance, measures based on exposed animals or exposure events are needed.

High resolution Cerenkov and range detectors for balloon-borne cosmic-ray experiment

NASA Technical Reports Server (NTRS)

Ahlen, S. P.; Cartwright, B. G.; Tarle, G.

1975-01-01

A combination of an active Cerenkov detector and passive range detectors is proposed for the high resolution measurement of isotopic composition in the neighborhood of iron in the galactic cosmic rays. A large area (4,300 sq cm) Cerenkov counter and passive range detectors were tested. Tests with heavy ions (2.1 GeV/amu C-12, 289 MeV/amu Ar-40, and 594 MeV/amu Ne-20) revealed the spatial uniformity of response of the Cerenkov counter to be better than 1% peak-to-peak. Light collection efficiency is independent of projectile energy and incidence angle to within at least 0.5%. Passive Lexan track recorders to measure range in the presence of the nuclear interaction background which results from stopping particles through 0.9 interaction lengths of matter were also tested. It was found that nuclear interactions produce an effective range straggling distribution only approximately 75% wider than that expected from range straggling alone. The combination of these tested techniques makes possible high mass resolution in the neighborhood of iron.

Veterinarians' attitudes toward antimicrobial use and selective dry cow treatment in the Netherlands.

PubMed

Scherpenzeel, C G M; Santman-Berends, I M G A; Lam, T J G M

2018-03-28

In the Netherlands, regulations have been in place since 2008 to reduce the overall use of antimicrobials to mitigate antimicrobial resistance. As part of these regulations, a ban on the preventive use of antimicrobials, such as applying blanket dry cow treatment, was introduced and alternative measures such as selective dry cow treatment (SDCT) were implemented. Both farmers and veterinarians play an important role in implementing these measures and have a shared responsibility with respect to prudent antimicrobial use (AMU). The attitude of Dutch dairy veterinarians toward restricted AMU and toward SDCT is unknown, but a favorable attitude toward this approach seems crucial for successful implementation. In 2015, an online questionnaire was collected from 181 veterinarians that contained questions with regard to their attitude and behavior toward reduction of AMU and toward SDCT. Descriptive statistics were used to describe the data, and multivariable logistic regression models with a logit link function were applied to evaluate potential associations between veterinarians' attitudes toward AMU and SDCT and the rationale behind their mindset, based on positive and negative aspects of reduction in AMU. The veterinarians were divided into 3 groups based on their opinion on 4 statements with regard to AMU and SDCT: veterinarians with an unfavorable, a neutral, and a favorable attitude toward reduction of AMU and toward SDCT. For the multivariable logistic regression analysis, the first 2 groups were combined and compared with the veterinarians with a favorable attitude. The general attitude of Dutch dairy veterinarians toward reduction of AMU was positive, and most expressed the belief that they can still be a good veterinarian when they prescribe less antimicrobials. Veterinarians indicated they progressively promoted SDCT beginning in 2013. Most veterinarians see the advice they provide to farmers on SDCT as the best possible approach and are convinced that their farmers apply this SDCT approach. The results of the multivariable analyses showed that veterinarians with a favorable attitude mentioned positive aspects of SDCT, such as an increased consciousness of AMU among farmers, improving animal health, reducing antimicrobial resistance, and a chance to add value for the farmer, more often than other veterinarians. The latter group significantly more often indicated negative aspects of SDCT, such as a higher risk of sick cows and feeling pushed to follow the rules. In conclusion, the general attitude of Dutch dairy veterinarians toward reduction of AMU and SDCT was found to be positive. However, given the influence veterinarians potentially have on the attitude of farmers and the variability found in their attitude and behavior, veterinarians need specific attention if regional or national programs are organized trying to change behavior of farmers and encourage prudent AMU and SDCT. Copyright © 2018 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Burkholderia sacchari DSM 17165: A source of compositionally-tunable block-copolymeric short-chain poly(hydroxyalkanoates) from xylose and levulinic acid.

PubMed

Ashby, Richard D; Solaiman, Daniel K Y; Nuñez, Alberto; Strahan, Gary D; Johnston, David B

2018-04-01

Burkholderia sacchari was used to produce poly-3-hydroxybutyrate-co-3-hydroxyvalerate block copolymers from xylose and levulinic acid. Levulinic acid was the preferred substrate resulting in 3-hydroxyvalerate (3HV) contents as high as 95 mol% at 24 h. The 3HB:3HV ratios were controlled by the initial levulinic acid media concentration and fermentation length. Higher levulinic acid concentrations and longer durations, resulted in polymers with two glass transition temperatures, each approximating those associated with poly-3HB and poly-3HV. 13 C NMR confirmed the presence of high concentrations of 3HB-3HB and 3HV-3HV homopolymeric dyads, while mass spectrometry of the partial hydrolysis products did not conform to Bernoullian statistics for randomness, confirming block sequences. MS/MS analysis of specific oligomers showed the mass-loss of 86 amu (a 3HB unit) and 100 amu (a 3HV unit) attesting to some randomness within the polymers. This study verifies the potential for producing Poly-3HB-block-3HV copolymers from inexpensive biorenewable feedstocks without sequential addition of carbon sources. Published by Elsevier Ltd.

A Sounding-based Severe Weather Tool to Support Daily Operations at Kennedy Space Center and Cape Canaveral Air Force Station

NASA Technical Reports Server (NTRS)

Bauman, William H.; Roeder, William P.

2014-01-01

People and property at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) are at risk when severe weather occurs. Strong winds, hail and tornadoes can injure individuals and cause costly damage to structures if not properly protected. NASA's Launch Services Program and Ground Systems Development and Operations Program and other KSC programs use the daily and weekly severe weather forecasts issued by the 45th Weather Squadron (45 WS) to determine if they need to limit an activity such as working on gantries, or protect property such as a vehicle on a pad. The 45 WS requested the Applied Meteorology Unit (AMU) develop a warm season (May-September) severe weather tool for use in the Meteorological Interactive Data Display System (MIDDS) based on the late morning, 1500 UTC (1100 local time), CCAFS (XMR) sounding. The 45 WS frequently makes decisions to issue a severe weather watch and other severe weather warning support products to NASA and the 45th Space Wing in the late morning, after the 1500 UTC sounding. The results of this work indicate that certain stability indices based on the late morning XMR soundings can depict differences between days with reported severe weather and days with no reported severe weather. The AMU determined a frequency of reported severe weather for the stability indices and implemented an operational tool in MIDDS.

Severe Weather Tool using 1500 UTC Cape Canaveral Air Force Station Soundings

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2013-01-01

People and property at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) are at risk when severe weather occurs. Strong winds, hail and tornadoes can injure individuals and cause costly damage to structures if not properly protected. NASA's Launch Services Program and Ground Systems Development and Operations Program and other KSC programs use the daily and weekly severe weather forecasts issued by the 45th Weather Squadron (45 WS) to determine if they need to limit an activity such as working on gantries, or protect property such as a vehicle on a pad. The 45 WS requested the Applied Meteorology Unit (AMU) develop a warm season (May-September) severe weather tool for use in the Meteorological Interactive Data Display System (MIDDS) based on the late morning, 1500 UTC (1100 local time), CCAFS (XMR) sounding. The 45 WS frequently makes decisions to issue a severe weather watch and other severe weather warning support products to NASA and the 45th Space Wing in the late morning, after the 1500 UTC sounding. The results of this work indicate that certain stability indices based on the late morning XMR soundings can depict differences between days with reported severe weather and days with no reported severe weather. The AMU determined a frequency of reported severe weather for the stability indices and implemented an operational tool in MIDDS.

Use of relativistic rise in ionization chambers for measurement of high energy heavy nuclei

NASA Technical Reports Server (NTRS)

Barthelmy, S. D.; Israel, M. H.; Klarmann, J.; Vogel, J. S.

1983-01-01

A balloon-borne instrument has been constructed to measure the energy spectra of cosmic-ray heavy nuclei in the range of about 0.3 to about 100 GeV/amu. It makes use of the relativistic rise portion of the Bethe-Bloch curve in ionization chambers for energy determination in the 10- to 100-GeV/amu interval. The instrument consists of six layers of dual-gap ionization chambers for energy determination above 10 GeV/amu. Charge is determined with a NE114 scintillator and a Pilot 425 plastic Cerenkov counter. A CO2 gas Cerenkov detector (1 atm; threshold of 30 GeV/amu) calibrates the ion chambers in the relativistic rise region. The main emphasis of the instrument is the determination of the change of the ratio of Iron (26) to the Iron secondaries (21-25) in the energy range of 10 to 100 GeV/amu. Preliminary data from a balloon flight in the fall of 1982 from Palestine, TX is presented.

Reducing Antimicrobial Usage in Pig Production without Jeopardizing Production Parameters.

PubMed

Postma, M; Vanderhaeghen, W; Sarrazin, S; Maes, D; Dewulf, J

2017-02-01

Antimicrobial usage (AMU) has been described to be high in pig production. Although farmers are aware of the high usage, little is known about intervention to improve the situation. This study evaluated the extent to which AMU could be reduced in pig production by the optimization of herd management, biosecurity status, vaccination strategy, anthelmintic therapy and advice on prudent AMU. Furthermore, the effects of these interventions on the herd production results were explored. This intervention study was conducted on 61 Flemish pig herds and included three visits per herd. During the initial visit, information was gathered on herd management, biosecurity status (quantified by means of the Biocheck.UGent ™ risk-based scoring system), vaccination strategy, anthelmintic therapy and AMU. This info was then translated into a herd-specific action plan which was discussed with the farmer and herd veterinarian/other advisors during the second visit. In the final herd visit (±8 months later), comparable data were obtained to evaluate the progress. Overall, a significant improvement of 2.4 points external and 7 points internal biosecurity on the herds was obtained, combined with additional vaccination, anthelmintic therapy and prudent AMU. This was accompanied by a significant reduction in the AMU with a decrease of 52% for the pigs from birth till slaughter and 32% for breeding animals, based on treatment incidences (TIs) and included an important reduction in the use of critically important antimicrobials. More importantly, the increased biosecurity levels and decreased AMU were combined with significantly improved technical results such as the number of weaned piglets per sow per year (+1.1), daily weight gain (+5.9 g/day) and mortality in the finisher period (-0.6%). Guided interventions as a team effort of farmer and herd veterinarian/other advisors have shown to be a promising method in the reduction of AMU in pig production. © 2016 Blackwell Verlag GmbH.

Constructed wetlands and solar-driven disinfection technologies for sustainable wastewater treatment and reclamation in rural India: SWINGS project.

PubMed

Álvarez, J A; Ávila, C; Otter, P; Kilian, R; Istenič, D; Rolletschek, M; Molle, P; Khalil, N; Ameršek, I; Mishra, V K; Jorgensen, C; Garfi, A; Carvalho, P; Brix, H; Arias, C A

2017-09-01

SWINGS was a cooperation project between the European Union and India, aiming at implementing state of the art low-cost technologies for the treatment and reuse of domestic wastewater in rural areas of India. The largest wastewater treatment plant consists of a high-rate anaerobic system, followed by vertical and horizontal subsurface flow constructed wetlands with a treatment area of around 1,900 m 2 and a final step consisting of solar-driven anodic oxidation (AO) and ultraviolet (UV) disinfection units allowing direct reuse of the treated water. The implementation and operation of two pilot plants in north (Aligarh Muslim University, AMU) and central India (Indira Gandhi National Tribal University, IGNTU) are shown in this study. The overall performance of AMU pilot plant during the first 7 months of operation showed organic matter removal efficiencies of 87% total suspended solids, 95% 5-day biological oxygen demand (BOD 5 ) and 90% chemical oxygen demand, while Kjeldahl nitrogen removal reached 89%. The UV disinfection unit produces water for irrigation and toilet flushing with pathogenic indicator bacteria well below WHO guidelines. On the other hand, the AO disinfection unit implemented at IGNTU and operated for almost a year has been shown to produce an effluent of sufficient quality to be reused by the local population for agriculture and irrigation.

Sensitivity and fragmentation calibration of the time-of-flight mass spectrometer RTOF on board ESA's Rosetta mission

NASA Astrophysics Data System (ADS)

Gasc, Sébastien; Altwegg, Kathrin; Jäckel, Annette; Le Roy, Léna; Rubin, Martin; Fiethe, Björn; Mall, Urs; Rème, Henri

2014-05-01

The European Space Agency's Rosetta mission will rendez-vous comet 67P/Churyumov-Gerasimenko (67P) in September 2014. The Rosetta spacecraft with the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) onboard will follow and survey 67P for more than a year until the comet reaches its perihelion and beyond. ROSINA will provide new information on the global molecular, elemental, and isotopic composition of the coma [1]. ROSINA consists of a pressure sensor (COPS) and two mass spectrometers, the Double Focusing Mass Spectrometer (DFMS) and the Reflectron Time Of Flight mass spectrometer (RTOF). RTOF has a wide mass range, from 1 amu/e to >300 amu/e, and contains two ion sources, a reflectron and two detectors. The two ion sources, the orthogonal and the storage source, are capable to measure cometary ions while the latter also allows measuring cometary neutral gas. In neutral gas mode the ionization is performed through electron impact. A built-in Gas Calibration Unit (GCU) contains a known gas mixture composed of He, CO2, and Kr that can be used for in-flight calibration of the instrument. Among other ROSINA specific scientific goals, RTOF's task will be to determine molecular composition of volatiles via measuring and separating heavy hydrocarbons; it has been designed to study the development of the cometary activity as well as the coma chemistry between 3.5 AU and perihelion. From the spectroscopic studies and in-situ observations of other comets, we expect to find molecules such as H2O, CO, CO2, hydrocarbons, alcohols, formaldehyde, and other organic compounds in the coma of 67P/Churyumov-Gerasimenko [2]. To demonstrate and quantify the sensitivity and functionality of RTOF, calibration measurements have been realized with more than 20 species among the most abundant molecules quoted above, as well as other species such as PAHs. We will describe the applied methods used to realize this calibration and will discuss our preliminary results, i.e. RTOF capabilities in terms of sensitivity, isotopic ratios, and fragmentation patterns. We will demonstrate that RTOF is well capable to meet the requirements to address the scientific questions discussed above. [1] Balsiger, H. et al.: ROSINA-Rosetta Orbiter Spectrometer for Ion and Neutral Analysis, Space Science Reviews, Vol. 128, 745-801, 2007. [2] Bockelée-Morvan, D., Crovisier, J., Mumma, M. J., and Weaver, H. A.: The Composition of Cometary Volatiles, in Comets II (M. C. Festou et al., eds), Univ. Arizona Press, Tucson, 2004

Anvil Tool in the Advanced Weather Interactive Processing System

NASA Technical Reports Server (NTRS)

Barrett, Joe, III; Bauman, William, III; Keen, Jeremy

2007-01-01

Meteorologists from the 45th Weather Squadron (45 WS) and Spaceflight Meteorology Group (SMG) have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violations of the lightning Launch Commit Criteria and Space Shuttle Flight Rules. As a result, the Applied Meteorology Unit (AMU) created a graphical overlay tool for the Meteorological Interactive Data Display Systems (MIDDS) to indicate the threat of thunderstorm anvil clouds, using either observed or model forecast winds as input. In order for the Anvil Tool to remain available to the meteorologists, the AMU was tasked to transition the tool to the Advanced Weather interactive Processing System (AWIPS). This report describes the work done by the AMU to develop the Anvil Tool for AWIPS to create a graphical overlay depicting the threat from thunderstorm anvil clouds. The AWIPS Anvil Tool is based on the previously deployed AMU MIDDS Anvil Tool. SMG and 45 WS forecasters have used the MIDDS Anvil Tool during launch and landing operations. SMG's primary weather analysis and display system is now AWIPS and the 45 WS has plans to replace MIDDS with AWIPS. The Anvil Tool creates a graphic that users can overlay on satellite or radar imagery to depict the potential location of thunderstorm anvils one, two, and three hours into the future. The locations are based on an average of the upper-level observed or forecasted winds. The graphic includes 10 and 20 nm standoff circles centered at the location of interest, in addition to one-, two-, and three-hour arcs in the upwind direction. The arcs extend outward across a 30 degree sector width based on a previous AMU study which determined thunderstorm anvils move in a direction plus or minus 15 degrees of the upper-level (300- to 150-mb) wind direction. This report briefly describes the history of the MIDDS Anvil Tool and then explains how the initial development of the AWIPS Anvil Tool was carried out. After testing was performed by SMG, 45 WS, and AMU, a number of needed improvements were identified. A bug report document was created that showed the status of each bug and desired improvement. This report lists the improvements that were made to increase the accuracy and user-friendliness of the tool. Final testing was carried out and documented and then the final version of the software and Users Guide was provided to SMG and the 45 WS. Several possible future improvements to the tool are identified that would increase the flexibility of the tool. This report contains a brief history of the development of the Anvil Tool in MIDDS, and then describes the transition and development of software to AWIPS.

GEMINI-TITAN (GT)-9 - MOCKUP - ADAPTER EQUIPMENT SECTION - FUEL CELL - MSC

NASA Image and Video Library

1966-03-01

S66-22686 (March 1966) --- Mock-up of the adapter equipment section to be used on the Gemini-9 spaceflight. This section provides volume and attach points for several system modules, including Orbit Attitude Maneuver System, Environmental Control System primary oxygen supply, batteries, coolant, and electrical and electric components. This section will also hold the Astronaut Maneuvering Unit (AMU) backpack (center). Photo credit: NASA

The first report of Japanese antimicrobial use measured by national database based on health insurance claims data (2011-2013): comparison with sales data, and trend analysis stratified by antimicrobial category and age group.

PubMed

Yamasaki, Daisuke; Tanabe, Masaki; Muraki, Yuichi; Kato, Genta; Ohmagari, Norio; Yagi, Tetsuya

2018-04-01

Our objective was to evaluate the utility of the national database (NDB) based on health insurance claims data for antimicrobial use (AMU) surveillance in medical institutions in Japan. The population-weighted total AMU expressed as defined daily doses (DDDs) per 1000 inhabitants per day (DID) was measured by the NDB. The data were compared with our previous study measured by the sales data. Trend analysis of DID from 2011 to 2013 and subgroup analysis stratified by antimicrobial category and age group were performed. There was a significant linear correlation between the AMUs measured by the sales data and the NDB. Total oral and parenteral AMUs (expressed in DID) were 1.04-fold from 12.654 in 2011 to 13.202 in 2013 and 1.13-fold from 0.734 to 0.829, respectively. Percentage of oral form among total AMU was high with more than 94% during the study period. AMU in the children group (0-14 years) decreased from 2011 to 2013 regardless of dosage form, although the working age group (15-64 years) and elderly group (65 and above years) increased. Oral AMU in the working age group was approximately two-thirds of those in the other age groups. In contrast, parenteral AMU in the elderly group was extremely high compared to the other age groups. The trend of AMU stratified by antimicrobial category and age group were successfully measured using the NDB, which can be a tool to monitor outcome indices for the national action plan on antimicrobial resistance.

Production of nearly monodisperse Fe3O4 and Fe@Fe3O4 nanoparticles in aqueous medium and their surface modification for biomedical applications

NASA Astrophysics Data System (ADS)

Tegafaw, Tirusew; Xu, Wenlong; Lee, Sang Hyup; Chae, Kwon Seok; Chang, Yongmin; Lee, Gang Ho

2017-02-01

Iron (Fe)-based nanoparticles are extremely valuable in biomedical applications owing to their low toxicity and high magnetization values at room temperature. In this study, we synthesized nearly monodisperse iron oxide (Fe3O4) and Fe@Fe3O4 (core: Fe, shell: Fe3O4) nanoparticles in aqueous medium under argon flow and then, coated them with various biocompatible ligands and silica. In this study, eight types of surface-modified nanoparticles were investigated, namely, Fe3O4@PAA (PAA = polyacrylic acid; Mw of PAA = 5100 amu and 15,000 amu), Fe3O4@PAA-FA (FA = folic acid; Mw of PAA = 5100 amu and 15,000 amu), Fe3O4@PEI-fluorescein (PEI = polyethylenimine; Mw of PEI = 1300 amu), Fe@Fe3O4@PEI (Mw of PEI = 10,000 amu), Fe3O4@SiO2 and Fe@Fe3O4@SiO2 nanoparticles. We characterized the prepared surface-modified nanoparticles using high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) absorption spectroscopy, a superconducting quantum interference device (SQUID), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) spectroscopy and confocal microscopy. Finally, we measured the cytotoxicity of the samples. The results indicate that the surface-modified nanoparticles are biocompatible and are potential candidates for various biomedical applications.

Accurate mass analysis of ethanesulfonic acid degradates of acetochlor and alachlor using high-performance liquid chromatography and time-of-flight mass spectrometry

USGS Publications Warehouse

Thurman, E.M.; Ferrer, I.; Parry, R.

2002-01-01

Degradates of acetochlor and alachlor (ethanesulfonic acids, ESAs) were analyzed in both standards and in a groundwater sample using high-performance liquid chromatography-time-of-flight mass spectrometry with electrospray ionization. The negative pseudomolecular ion of the secondary amide of acetochlor ESA and alachlor ESA gave average masses of 256.0750??0.0049 amu and 270.0786??0.0064 amu respectively. Acetochlor and alachlor ESA gave similar masses of 314.1098??0.0061 amu and 314.1153??0.0048 amu; however, they could not be distinguished by accurate mass because they have the same empirical formula. On the other hand, they may be distinguished using positive-ion electrospray because of different fragmentation spectra, which did not occur using negative-ion electrospray.

Accurate mass analysis of ethanesulfonic acid degradates of acetochlor and alachlor using high-performance liquid chromatography and time-of-flight mass spectrometry

USGS Publications Warehouse

Thurman, E.M.; Ferrer, Imma; Parry, R.

2002-01-01

Degradates of acetochlor and alachlor (ethanesulfonic acids, ESAs) were analyzed in both standards and in a groundwater sample using high-performance liquid chromatography-time-of-flight mass spectrometry with electrospray ionization. The negative pseudomolecular ion of the secondary amide of acetochlor ESA and alachlor ESA gave average masses of 256.0750+/-0.0049 amu and 270.0786+/-0.0064 amu respectively. Acetochlor and alachlor ESA gave similar masses of 314.1098+/-0.0061 amu and 314.1153+/-0.0048 amu; however, they could not be distinguished by accurate mass because they have the same empirical formula. On the other hand, they may be distinguished using positive-ion electrospray because of different fragmentation spectra, which did not occur using negative-ion electrospray.

Local Data Integration in East Central Florida Using the ARPS Data Analysis System

NASA Technical Reports Server (NTRS)

Case, Jonathan; Manobianco, John

1998-01-01

This paper describes the Applied Meteorology Unit's (AMU) efforts to configure, implement, and test a version of the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS; Brewster 1996) that assimilates all available data within 250 km of the Kennedy Space Center (KSC) and the Eastern Range at Cape Canaveral Air Station (CCAS). The objective for running a Local Data Integration System (LDIS) such as ADAS is to generate products which may enhance weather nowcasts and short-range (less than 6 h) forecasts issued in support of ground and aerospace operations at KSC/CCAS. A LDIS such as ADAS has the potential to provide added value because it combines observational data to produce gridded analyses of temperature, wind, and moisture (including clouds) and diagnostic quantities such as vorticity, divergence, etc. at specified temporal and spatial resolutions. In this regard, a LDTS along with suitable visualization tools may provide users with a ignore complete and comprehensive understanding of evolving weather than could be developed by individually examining the disparate data sets over the same area and time. The AMU implemented a working prototype of the ADAS which does not run in real-time. Instead, the AMU is evaluating ADAS through post-analyses of weather events for a warm and cool season case. The case studies were chosen to investigate the capabilities and limitations of a LDIS such as ADAS including the impact of non-incorporation of specific data sources on the utility of the subsequent analyses.

Determining the Probability of Violating Upper-Level Wind Constraints for the Launch of Minuteman Ill Ballistic Missiles At Vandenberg Air Force Base

NASA Technical Reports Server (NTRS)

Shafer, Jaclyn A.; Brock, Tyler M.

2013-01-01

The 30th Operational Support Squadron Weather Flight (30 OSSWF) provides comprehensive weather services to the space program at Vandenberg Air Force Base (VAFB) in California. One of their responsibilities is to monitor upper-level winds to ensure safe launch operations of the Minuteman Ill ballistic missile. The 30 OSSWF requested the Applied Meteorology Unit (AMU) analyze VAFB sounding data to determine the probability of violating (PoV) upper-level thresholds for wind speed and shear constraints specific to this launch vehicle, and to develop a graphical user interface (GUI) that will calculate the PoV of each constraint on the day of launch. The AMU suggested also including forecast sounding data from the Rapid Refresh (RAP) model. This would provide further insight for the launch weather officers (LWOs) when determining if a wind constraint violation will occur over the next few hours, and help to improve the overall upper winds forecast on launch day.

Interpretation of the ion mass spectra in the mass per charge range 25-35 amu/e obtained in the inner coma of Halley's comet by the HIS-sensor of the Giotto IMS experiment

NASA Technical Reports Server (NTRS)

Geiss, J.; Altwegg, K.; Anders, E.; Balsiger, H.; Meier, A.; Shelley, E. G.; Ip, W.-H.; Rosenbauer, H.; Neugebauer, M.

1991-01-01

The IMS-HIS double-focusing mass spectrometer that flew on the Giotto spacecraft covered the mass per charge range from 12 to 56 (amu/e). By comparing flight data, calibration data and results of model calculations of the ion population in the inner coma, the absolute mass scale is established, and ions in the mass range 25 to 35 are identified. Ions resulting from protonation of molecules with high proton affinity are relatively abundant, enabling us to estimate relative source strengths for H2CO, CH3OH, HCN, and H2S, providing for the first time a positive in situ measurement of methanol. Also, upper limits for NO and some hydrocarbons are derived.

Antimicrobial use through feed, water, and injection in 20 swine farms in Alberta and Saskatchewan

PubMed Central

Rosengren, Leigh B.; Waldner, Cheryl L.; Reid-Smith, Richard J.; Harding, John C.S.; Gow, Sheryl P.; Wilkins, Wendy L.

2008-01-01

Antimicrobial resistance (AMR) is an emerging animal welfare and public health issue linked to antimicrobial use (AMU) in livestock. This study was conducted in 2004 on 20 swine farms in Alberta and Saskatchewan. On-farm records and questionnaires were used to retrospectively describe the antimicrobial exposures of pigs through feed, water, and injection. Antimicrobial use in all production categories was described over 12 months. On-farm records and questionnaires provided sufficient data to describe antimicrobial exposure rates through feed and water. In contrast, on-farm records did not supply sufficient data to describe parenteral antimicrobial exposure rates. Records lacked data on the number of exposures per treatment, therefore parenteral AMU was described as an exposure incidence. Parenteral exposure records were often unavailable for pigs less than 22 kg, in which case questionnaires were used. The incidence of parenteral AMU was significantly higher in herds reporting exposure by questionnaire compared with existing records, suggesting that on-farm records did not reliably describe parenteral AMU. However, because antimicrobial exposures in feed and water were markedly more common than through injection, it was concluded that existing on-farm data would be a valuable resource for investigating AMU and AMR in pigs. PMID:18505203

Antimicrobial use surveillance in broiler chicken flocks in Canada, 2013-2015

PubMed Central

Irwin, Rebecca J.; Reid-Smith, Richard J.

2017-01-01

There is a paucity of data on the reason for and the quantity of antimicrobials used in broiler chickens in Canada. To address this, the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) implemented surveillance of antimicrobial use (AMU) and antimicrobial resistance (AMR) in broiler chicken flocks in 2013. Shortly after this (2014), the poultry industry banned the preventive use of ceftiofur in broiler chickens. The objectives of this analysis were to describe antimicrobial use (AMU) in Canadian broiler chickens between 2013 and 2015 (n = 378 flocks), compare these results to other animal species in Canada, to highlight the utility of farm surveillance data to evaluate the impact of a policy change, and to explore how different antimicrobial use metrics might affect data interpretation and communication. The surveillance data indicated that the poultry industry policy resulted in lower antimicrobial use and resistance, and they successfully captured information on when, where, why, and how much antimicrobials were being used. The majority of antimicrobials were administered via the feed (95%). The relative frequency of antimicrobial classes used in broiler chickens differed from those used in swine or in food animal production in general. Coccidiostats were the most frequently used antimicrobial classes (53% of total kg). Excluding coccidiostats, the top three most frequently used antimicrobial classes were bacitracin (53% of flocks), virginiamycin (25%) and avilamycin (21%), mainly used for the prevention of necrotic enteritis. Depending on the AMU metric utilized, the relative rankings of the top antimicrobials changed; hence the choice of the AMU metric is an important consideration for any AMU reporting. When using milligrams/Population Correction Unit (mg/PCU) the top three antimicrobial classes used were bacitracins (76 mg/PCU), trimethoprim-sulfonamides (24 mg/PCU), and penicillins (15 mg/PCU), whereas when using a number of Defined Daily Doses in animals using Canadian standards /1,000 chicken-days at risk (nDDDvetCA/1,000 CD) the ranking was bacitracins (223 nDDDvetCA/1,000 CD), streptogramins (118 nDDDvetCA/1,000 CD), and trimethoprim-sulfonamides (87 nDDDvetCA/1,000 CD). The median animal treatment days in feed for one cycle (ATD/cycle) during the three-year study were 34 ATD/cycle; this was equal to the mean age of the flocks at pre-harvest sampling day (days at risk), indicating that the studied flocks except those that were raised without antibiotics and organic, were fed with medicated rations throughout the observation period. Overall, more than half (59%) of antimicrobials used in broiler chickens were in classes not used in human medicine, such as ionophores and chemical coccidiostats aimed to prevent coccidiosis. Compared to grower-finisher pigs and in production animal species (national sales data), the mg/PCU of antimicrobials used in broiler chickens was relatively lower. The findings of this paper highlighted the importance of farm-level AMU surveillance in measuring the impact of interventions to reduce antimicrobials in poultry. PMID:28658278

Comparison of treatment records and inventory of empty drug containers to quantify antimicrobial usage in dairy herds.

PubMed

Nobrega, Diego B; De Buck, Jeroen; Naqvi, S Ali; Liu, Gang; Naushad, Sohail; Saini, Vineet; Barkema, Herman W

2017-12-01

Assessment of antimicrobial use (AMU) is vital for interpreting the origin of changes in antimicrobial resistance (AMR). The objectives of the present study were to estimate the association between AMU determined using on-farm treatment records (TR) and inventory of empty drug containers (INV). Herds were selected to represent Canadian dairy farms. Producers were asked to record animal health events and treatments on a standard General Health Event form. For inventory data, 40-L receptacles were placed at various locations considered convenient to deposit all empty drug containers. Antimicrobial defined-daily dosages (ADD) were calculated for 51 Canadian herds using the 2 methods. Estimation of AMU was 31,840 ADD using the INV and 14,487 ADD using the TR, indicating that for every TR entry, 2.20 times more treatments were observed using the INV. Mastitis, reproductive conditions, and dry cow therapy were the most frequent reasons for antimicrobial therapy when assessing TR. For all antimicrobials evaluated, mean ADD was higher using the INV versus TR. Regardless, a strong positive correlation (0.80) was observed between the 2 methods, indicating that herds with increased number of ADD recorded using the INV also had increased number of ADD recorded using TR. Furthermore, a positive association was observed for the 6 most commonly used antimicrobials. In comparison to methods used in surveillance programs on AMU in livestock that assume a constant use in all herds (i.e., sales data), INV provided a herd-level specific quantity of AMU positively correlated with AMU recorded at the animal level in general. The INV was easy to implement and provided a measure of total AMU in the herd. Availability of such information would be valuable for interpreting changes in AMR at the herd level and enabling evaluation of interventions for decreasing AMR. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Intermediate energy heavy ions: An emerging multi-disciplinary research tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alonso, J.R.

1988-10-01

In the ten years that beams of intermediate energy ({approx}50 MeV/amu{le}E{le}{approx}2 GeV/amu) heavy ions (Z{le}92) have been available, an increasing number of new research areas have been opened up. Pioneering work at the Bevalac at the Lawrence Berkeley Laboratory, still the world's only source of the heaviest beams in this energy range, has led to the establishment of active programs in nuclear physics, atomic physics, cosmic ray physics, as well as biology and medicine, and industrial applications. The great promise for growth of these research areas has led to serious planning for new facilities capable of delivering such beams; severalmore » such facilities are now in construction around the world. 20 refs., 5 figs., 1 tab.« less

Situational Lightning Climatologies

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred

2010-01-01

Research has revealed distinct spatial and temporal distributions of lightning occurrence that are strongly influenced by large-scale atmospheric flow regimes. It was believed there were two flow systems, but it has been discovered that actually there are seven distinct flow regimes. The Applied Meteorology Unit (AMU) has recalculated the lightning climatologies for the Shuttle Landing Facility (SLF), and the eight airfields in the National Weather Service in Melbourne (NWS MLB) County Warning Area (CWA) using individual lightning strike data to improve the accuracy of the climatologies. The software determines the location of each CG lightning strike with 5-, 10-, 20-, and 30-nmi (.9.3-, 18.5-, 37-, 55.6-km) radii from each airfield. Each CG lightning strike is binned at 1-, 3-, and 6-hour intervals at each specified radius. The software merges the CG lightning strike time intervals and distance with each wind flow regime and creates probability statistics for each time interval, radii, and flow regime, and stratifies them by month and warm season. The AMU also updated the graphical user interface (GUI) with the new data.

Mass spectra of neutral particles released during electrical breakdown of thin polymer films

NASA Technical Reports Server (NTRS)

Kendall, B. R. F.

1985-01-01

A special type of time-of-flight mass spectrometer triggered from the breakdown event was developed to study the composition of the neutral particle flux released during the electrical breakdown of polymer films problem. Charge is fed onto a metal-backed polymer surface by a movable smooth platinum contact. A slowly increasing potential from a high-impedance source is applied to the contact until breakdown occurs. The breakdown characteristics is made similar to those produced by an electron beam charging system operating at similar potentials. The apparatus showed that intense instantaneous fluxes of neutral particles are released from the sites of breakdown events. For Teflon FEP films of 50 and 75 microns thickness the material released consists almost entirely of fluorocarbon fragments, some of them having masses greater than 350 atomic mass units amu, while the material released from a 50 micron Kapton film consists mainly of light hydrocarbons with masses at or below 44 amu, with additional carbon monoxide and carbon dioxide. The apparatus is modified to allow electron beam charging of the samples.

Applied Meteorology Unit (AMU) Quarterly Report Third Quarter FY · 13

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Shafer, Jaclyn; Huddleston, Lisa

2013-01-01

The AMU team worked on seven tasks for their customers: (1) Ms. Crawford completed the objective lightning forecast tool for east -central Florida airports and delivered the tool and the final report to the customers. (2) Ms. Shafer continued work for Vandenberg Air Force Base on an automated tool to relate pressure gradients to peak winds. (3) Dr. Huddleston updated and delivered the tool that shows statistics on the timing of the first lightning strike of the day in the Kennedy Space Center (KSC)/Cape Canaveral Air Force Station (CCAFS) area. (4) Dr. Bauman continued work on a severe weather forecast tool focused on the Eastern Range (ER). (5) Ms. Crawford acquired the software and radar data needed to create a dual-Doppler analysis over the east-central Florida and KSC/CCAFS areas. (6) Mr. Decker continued developing a wind pairs database for the Launch Services Program to use when evaluating upper-level winds for launch vehicles. (7) Dr. Watson continued work to assimilate observational data into the high-resolution model configurations she created for Wallops Flight Facility and the ER.

Objective Lightning Probability Forecasts for East-Central Florida Airports

NASA Technical Reports Server (NTRS)

Crawford, Winfred C.

2013-01-01

The forecasters at the National Weather Service in Melbourne, FL, (NWS MLB) identified a need to make more accurate lightning forecasts to help alleviate delays due to thunderstorms in the vicinity of several commercial airports in central Florida at which they are responsible for issuing terminal aerodrome forecasts. Such forecasts would also provide safer ground operations around terminals, and would be of value to Center Weather Service Units serving air traffic controllers in Florida. To improve the forecast, the AMU was tasked to develop an objective lightning probability forecast tool for the airports using data from the National Lightning Detection Network (NLDN). The resulting forecast tool is similar to that developed by the AMU to support space launch operations at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) for use by the 45th Weather Squadron (45 WS) in previous tasks (Lambert and Wheeler 2005, Lambert 2007). The lightning probability forecasts are valid for the time periods and areas needed by the NWS MLB forecasters in the warm season months, defined in this task as May-September.

The ion population between 1300 km and 230000 km in the coma of comet P/Halley

NASA Technical Reports Server (NTRS)

Altwegg, K.; Balsiger, H.; Geiss, J.; Goldstein, R.; Ip, W. -H.; Meier, A.; Neugebauer, M.; Rosenbauer, H.; Shelley, E.

1993-01-01

During the encounter of the spacecraft Giotto with Comet Halley the two sensors of the ion mass spectrometer (IMS), high energy range spectrometer (HERS) and high intensity spectrometer (HIS), measured the mass and the three-dimensional velocity distributions of cometary ions. HIS looked mainly at the cold, slow part of the distribution close to the nucleus, HERS at the more energetic pick-up ions further out. After a thorough recalibration of the HIS flight spare unit and an extensive data analysis we present here continuous ion density-, composition-, velocity-, and temperature profiles for the water group ion (mass range 16-19 amu/e) along Giotto's inbound trajectory from 230,000 to 1300 km from the comet nucleus. The two sensors are in very good agreement in the region where their measurements overlap thus giving an excellent data base for the discussion of theoretical comet models. The most prominent feature where models and observations disagree is the so called pile up region between 8000 and 15,000 km from the nucleus.

Petroleum geology of Amu-Dar'ya province of Soviet Central Asia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clarke J.W.

1986-05-01

The Amu-Dar'ya oil and gas province extends over an area of 360,000 km/sup 2/ in central and eastern Turkmenia and western Uzbekistan in southern Soviet Central Asia. The province coincides with the eastern half of the Turan platform. A Mesozoic-Cenozoic sedimentary cover, 2-7 km thick, rests on a folded paleozoic basement. An Upper Jurassic salt unit divides the sedimentary section into subsalt and suprasalt parts. The structure of the sedimentary cover developed by vertical movements during the Mesozoic and Cenozoic, most of it during the late Tertiary in response to Alpine tectonism. Consequently, much of the trap formation and fillingmore » is late in geologic time and is apparently in progress at present. The province is gas prone; only in the Bukhara area on the east is there significant oil. Five plays are recognized. The Lower to Middle Jurassic play consists of alternating clays, sandstone, and siltstone. Thickness is 100-400 m. The Upper Jurassic play consists of Callovian-Oxfordian carbonate deposits, which are up to 500 m thick. The seal is Kimmeridgian-Tithonian salt. The carbonate deposits of this play are commonly a reef facies. The Lower Cretaceous play consists largely of alternating sandstone, clays, and siltstones. The seal is a clay unit of late Aptian and Albian age, which also separates this play from the overlying Albian-Cenomanian play. The Albian-Cenomanian play has sandstone and siltstone reservoirs, and the seal is a Turonian clay unit. The Paleogene play is prospective in the northeast part of the study area in the so-called Bukhara clastic beds.« less

The evaluation of ASOS for the Kennedy Space Center's Shuttle Landing Facility

NASA Technical Reports Server (NTRS)

Yersavich, Ann; Wheeler, Mark; Taylor, Gregory; Schumann, Robin; Manobianco, John

1994-01-01

This report documents the Applied Meteorology Unit's (AMU) evaluation of the effectiveness and utility of the Automated Surface Observing System (ASOS) in terms of spaceflight operations and user requirements. In particular, the evaluation determines which of the Shuttle Landing Facility (SLF) observation requirements can be satisfied by ASOS. This report also includes a summary of ASOS' background, current configuration and specifications, system performance, and the possible concepts of operations for use of ASOS at the SLF. This evaluation stems from a desire by the Air Force to determine if ASOS units could be used to reduce the cost of SLF meteorological observations.

Assessment of undiscovered continuous gas resources in the Amu Darya Basin Province of Turkmenistan, Uzbekistan, Iran, and Afghanistan, 2017

USGS Publications Warehouse

Schenk, Christopher J.; Tennyson, Marilyn E.; Mercier, Tracey J.; Hawkins, Sarah J.; Gaswirth, Stephanie B.; Marra, Kristen R.; Klett, Timothy R.; Le, Phuong A.; Brownfield, Michael E.; Woodall, Cheryl A.

2017-08-17

Using a geology-based assessment methodology, the U.S. Geological Survey estimated mean undiscovered, technically recoverable continuous resources of 35.1 trillion cubic feet of gas in the Amu Darya Basin Province of Turkmenistan, Uzbekistan, Iran, and Afghanistan.

Anvil Forecast Tool in the Advanced Weather Interactive Processing System, Phase II

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III

2008-01-01

Meteorologists from the 45th Weather Squadron (45 WS) and Spaceflight Meteorology Group have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violations of the Lightning Launch Commit Criteria and Space Light Rules. As a result, the Applied Meteorology Unit (AMU) created a graphical overlay tool for the Meteorological Interactive Data Display Systems (MIDDS) to indicate the threat of thunderstorm anvil clouds, using either observed or model forecast winds as input.

Analysis of Rapidly Developing Low Cloud Ceilings in a Stable Environment

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Barrett, Joe H., III; Case, Jonathan L.; Wheeler, Mark M.; Baggett, G. Wayne

2006-01-01

Forecasters at the Space Meteorology Group (SMG) issue 30 to 90 minute forecasts for low cloud ceilings at the Space Shuttle Landing Facility (TTS) to support Space Shuttle landings. Mission verification statistics have shown ceilings to be the number one forecast challenge for SMG. More specifically, forecasters at SMG are concerned with any rapidly developing clouds/ceilings below 8000 ft in a stable, capped thermodynamic environment. Therefore, the Applied Meteorology Unit (AMU) was tasked to examine archived events of rapid stable cloud formation resulting in ceilings below 8000 ft, and document the atmospheric regimes favoring this type of cloud development. The AMU examined the cool season months of November to March during the years of 1993-2003 for days that had low-level inversions and rapid, stable low cloud formation that resulted in ceilings violating the Space Shuttle Flight Rules. The AMU wrote and modified existing code to identify inversions from the morning (-10 UTC) Cape Canaveral, FL rawinsonde (XMR) during the cool season and output pertinent sounding information. They parsed all days with cloud ceilings below 8000 ft at TTS, forming a database of possible rapidly-developing low ceiling events. Days with precipitation or noticeable fog burn-off situations were excluded from the database. In the first phase of this work, only the daytime hours were examined for possible ceiling development events since low clouds are easier to diagnose with visible satellite imagery. Phase II of this work includes expanding the database to include nighttime cases which is underway as this abstract is being written. For the nighttime cases, the AMU will analyze both the 00 UTC soundings and the 10 UTC soundings to examine those data for the presence of a low-level inversion. The 00 UTC soundings will probably not have a surface-based inversion, but the presence of inversions or "neutral" layers aloft and below 8,000 ft will most likely help define the stable regime, being a thermodynamically "capped" environment. Occurrences of elevated low-level inversions or stable layers will be highlighted in conjunction with nights that experienced a possible development or onset of cloud ceilings below 8,000 ft. Using these criteria to narrow down the database, the AMU will then use archived IR satellite imagery for these possible events. This presentation summarizes the composite meteorological conditions for 20 daytime event days with rapid low cloud ceiling formation and 48 non-events days consisting of advection or widespread low cloud ceilings and describes two sample cases of daytime rapidly-developing low cloud ceilings. The authors will also summarize the work from the nighttime cases and describe a representative sample case from this data set.

"SHOUT" to improve the quality of care delivered to patients with acute kidney injury at Great Western Hospital.

PubMed

Brady, Paul; Gorham, James; Kosti, Angeliki; Seligman, William; Courtney, Alona; Mazan, Karolina; Paterson, Stuart; Ramcharitar, Steve; Chandrasekaran, Badri; Juniper, Mark; Greamspet, Mala; Daniel, Jessica; Chalstrey, Sue; Ahmed, Ijaz; Dasgupta, Tanaji

2015-01-01

Acute kidney injury (AKI) affects up to 20% of all patients admitted to hospital, and is associated with a higher risk of adverse clinical outcomes, increased healthcare costs, as well as long term risks of chronic kidney disease and end stage renal failure. The aim of this project was to improve the quality of care for patients with AKI admitted to the acute medical unit (AMU) at the Great Western Hospital (GWH). We assessed awareness and self reported confidence among physicians in our Trust, in addition to basic aspects of care relevant to AKI on our AMU. A multifaceted quality improvement strategy was developed, which included measures to improve awareness such as a Trust wide AKI awareness day, and reconfiguring the admission proforma on our AMU in order to enhance risk assessment, staging, and early response to AKI. Ancillary measures such as the dissemination of flashcards for lanyards containing core information were also used. Follow up assessments showed that foundation year one (FY1) doctors' self reported confidence in managing AKI increased from 2.8 to 4.2, as measured on a five point Likert scale (P=0.0003). AKI risk assessment increased from 13% to 57% (P=0.07) following a change in the admission proforma. Documentation of the diagnosis of AKI increased from 66% to 95% (P=0.038) among flagged patients. Documentation of urine dip results increased from 33% to 73% (P=0.01), in addition to a rise in appropriate referral for specialist input, although this was not statistically significant. Our results suggest that using the twin approaches of improving awareness, and small changes to systemic factors such as modification of the admission proforma, can lead to significant enhancements in the quality of care of patients with AKI.

Anvil Forecast Tool in the Advanced Weather Interactive Processing System (AWIPS)

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III; Hood, Doris

2009-01-01

Launch Weather Officers (LWOs) from the 45th Weather Squadron (45 WS) and forecasters from the National Weather Service (NWS) Spaceflight Meteorology Group (SMG) have identified anvil forecasting as one of their most challenging tasks when predicting the probability of violating the Lightning Launch Commit Criteria (LLCC) (Krider et al. 2006; Space Shuttle Flight Rules (FR), NASA/JSC 2004)). As a result, the Applied Meteorology Unit (AMU) developed a tool that creates an anvil threat corridor graphic that can be overlaid on satellite imagery using the Meteorological Interactive Data Display System (MIDDS, Short and Wheeler, 2002). The tool helps forecasters estimate the locations of thunderstorm anvils at one, two, and three hours into the future. It has been used extensively in launch and landing operations by both the 45 WS and SMG. The Advanced Weather Interactive Processing System (AWIPS) is now used along with MIDDS for weather analysis and display at SMG. In Phase I of this task, SMG tasked the AMU to transition the tool from MIDDS to AWIPS (Barrett et aI., 2007). For Phase II, SMG requested the AMU make the Anvil Forecast Tool in AWIPS more configurable by creating the capability to read model gridded data from user-defined model files instead of hard-coded files. An NWS local AWIPS application called AGRID was used to accomplish this. In addition, SMG needed to be able to define the pressure levels for the model data, instead of hard-coding the bottom level as 300 mb and the top level as 150 mb. This paper describes the initial development of the Anvil Forecast Tool for MIDDS, followed by the migration of the tool to AWIPS in Phase I. It then gives a detailed presentation of the Phase II improvements to the AWIPS tool.

IRIS Product Recommendations

NASA Technical Reports Server (NTRS)

Short, David A.

2000-01-01

This report presents the Applied Meteorology Unit's (AMU) evaluation of SIGMET Inc.'s Integrated Radar Information System (IRIS) Product Generator and recommendations for products emphasizing lightning and microburst tools. The IRIS Product Generator processes radar reflectivity data from the Weather Surveillance Radar, model 74C (WSR-74C), located on Patrick Air Force Base. The IRIS System was upgraded from version 6.12 to version 7.05 in late December 1999. A statistical analysis of atmospheric temperature variability over the Cape Canaveral Air Force Station (CCAFS) Weather Station provided guidance for the configuration of radar products that provide information on the mixed-phase (liquid and ice) region of clouds, between 0 C and -20 C. Mixed-phase processes at these temperatures are physically linked to electrification and the genesis of severe weather within convectively generated clouds. Day-to-day variations in the atmospheric temperature profile are of sufficient magnitude to warrant periodic reconfiguration of radar products intended for the interpretation of lightning and microburst potential of convectively generated clouds. The AMU also examined the radar volume-scan strategy to determine the scales of vertical gaps within the altitude range of the 0 C to -20 C isotherms over the Kennedy Space Center (KSC)/CCAFS area. This report present's two objective strategies for designing volume scans and proposes a modified scan strategy that reduces the average vertical gap by 37% as a means for improving radar observations of cloud characteristics in the critical 0 C to -20 C layer. The AMU recommends a total of 18 products, including 11 products that require use of the IRIS programming language and the IRIS User Product Insert feature. Included is a cell trends product and display, modeled after the WSR-88D cell trends display in use by the National Weather Service.

ADAS Update and Maintainability

NASA Technical Reports Server (NTRS)

Watson, Leela R.

2010-01-01

Since 2000, both the National Weather Service Melbourne (NWS MLB) and the Spaceflight Meteorology Group (SMG) have used a local data integration system (LOIS) as part of their forecast and warning operations. The original LOIS was developed by the Applied Meteorology Unit (AMU) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (AD AS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features. Over the years, the LDIS has become problematic to maintain since it depends on AMU-developed shell scripts that were written for an earlier version of the ADAS software. The goals of this task were to update the NWS MLB/SMG LDIS with the latest version of ADAS, incorporate new sources of observational data, and upgrade and modify the AMU-developed shell scripts written to govern the system. In addition, the previously developed ADAS graphical user interface (GUI) was updated. Operationally, these upgrades will result in more accurate depictions of the current local environment to help with short-range weather forecasting applications, while also offering an improved initialization for local versions of the Weather Research and Forecasting (WRF) model used by both groups.

Assessment of undiscovered oil and gas resources of the Amu Darya Basin and Afghan-Tajik Basin Provinces, Afghanistan, Iran, Tajikistan, Turkmenistan, and Uzbekistan, 2011

USGS Publications Warehouse

Klett, T.R.; Schenk, Christopher J.; Wandrey, Craig J.; Charpentier, Ronald R.; Brownfield, Michael E.; Pitman, Janet K.; Pollastro, Richard M.; Cook, Troy A.; Tennyson, Marilyn E.

2012-01-01

Using a geology-based assessment methodology, the U.S. Geological Survey estimated volumes of undiscovered, technically recoverable, conventional petroleum resources for the Amu Darya Basin and Afghan–Tajik Basin Provinces of Afghanistan, Iran, Tajikistan, Turkmenistan, and Uzbekistan. The mean volumes were estimated at 962 million barrels of crude oil, 52 trillion cubic feet of natural gas, and 582 million barrels of natural gas liquids for the Amu Darya Basin Province and at 946 million barrels of crude oil, 7 trillion cubic feet of natural gas, and 85 million barrels of natural gas liquids for the Afghan–Tajik Basin Province.

Fermilab Muon g-2 Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorringe, Tim

The Fermilab muon g-2 experiment will measure the muon anomalous magnetic momentmore » $$a_{\\mu}$$ to 140 ppb – a four-fold improvement over the earlier Brookhaven experiment. The measurement of $$a_{\\mu}$$ is well known as a unique test of the standard model with broad sensitivity to new interactions, particles and phenomena. The goal of 140 ppb is commensurate with ongoing improvements in the SM prediction of the anomalous moment and addresses the longstanding 3.5$$\\sigma$$ discrepancy between the BNL result and the SM prediction. In this article I discuss the physics motivation and experimental technique for measuring $$a_{\\mu}$$, and the current status and the future work for the project.« less

Volume Averaged Height Integrated Radar Reflectivity (VAHIRR) Cost-Benefit Analysis

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2008-01-01

Lightning Launch Commit Criteria (LLCC) are designed to prevent space launch vehicles from flight through environments conducive to natural or triggered lightning and are used for all U.S. government and commercial launches at government and civilian ranges. They are maintained by a committee known as the NASA/USAF Lightning Advisory Panel (LAP). The previous LLCC for anvil cloud, meant to avoid triggered lightning, have been shown to be overly restrictive. Some of these rules have had such high safety margins that they prohibited flight under conditions that are now thought to be safe 90% of the time, leading to costly launch delays and scrubs. The LLCC for anvil clouds was upgraded in the summer of 2005 to incorporate results from the Airborne Field Mill (ABFM) experiment at the Eastern Range (ER). Numerous combinations of parameters were considered to develop the best correlation of operational weather observations to in-cloud electric fields capable of rocket triggered lightning in anvil clouds. The Volume Averaged Height Integrated Radar Reflectivity (VAHIRR) was the best metric found. Dr. Harry Koons of Aerospace Corporation conducted a risk analysis of the VAHIRR product. The results indicated that the LLCC based on the VAHIRR product would pose a negligible risk of flying through hazardous electric fields. Based on these findings, the Kennedy Space Center Weather Office is considering seeking funding for development of an automated VAHIRR algorithm for the new ER 45th Weather Squadron (45 WS) RadTec 431250 weather radar and Weather Surveillance Radar-1988 Doppler (WSR-88D) radars. Before developing an automated algorithm, the Applied Meteorology Unit (AMU) was tasked to determine the frequency with which VAHIRR would have allowed a launch to safely proceed during weather conditions otherwise deemed "red" by the Launch Weather Officer. To do this, the AMU manually calculated VAHIRR values based on candidate cases from past launches with known anvil cloud LLCC violations. An automated algorithm may be developed if the analyses from past launches show VAHIRR would have provided a significant cost benefit by allowing a launch to proceed. The 45 WS at the ER and 30th Weather Squadron (30 WS) at the Western Range provided the AMU with launch weather summaries from past launches that were impacted by LLCC. The 45 WS provided summaries from 14 launch attempts and the 30 WS fkom 5. The launch attempts occurred between December 2001 and June 2007. These summaries helped the AMU determine when the LLCC were "red" due to anvil cloud. The AMU collected WSR-88D radar reflectivity, cloud-to-ground lightning strikes, soundings and satellite imagery. The AMU used step-by-step instructions for calculating VAHIRR manually as provided by the 45 WS. These instructions were used for all of the candidate cases when anvil cloud caused an LLCC violation identified in the launch weather summaries. The AMU evaluated several software programs capable of visualizing radar data so that VAHIRR could be calculated and chose GR2Analyst from Gibson Ridge Software, LLC. Data availability and lack of detail from some launch weather summaries permitted analysis of six launch attempts from the ER and none from the WR. The AMU did not take into account whether or not other weather LCC violations were occurring at the same time as the anvil cloud LLCC since the goal of this task was to determine how often VAHIRR provided relief to the anvil cloud LLCC at any time during several previous launch attempts. Therefore, in the statistics presented in this report, it is possible that even though VAHIRR provided relief to the anvil cloud LLCC, other weather LCC could have been violated not permitting the launch to proceed. The results of this cost-benefit analysis indicated VAHIRR provided relief from the anvil cloud LLCC between about 15% and 18% of the time for varying 5-minute time periods based on summaries fkom six launch attempts and would have allowed launch to proceed that were otherwise "NO GO" due to the anvil cloud LLCC if the T-0 time occurred during the anvil cloud LLCC violations.

Stable Low Cloud Phase II: Nocturnal Event Study

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Barrett, Joe, III

2007-01-01

This report describes the work done by the Applied Meteorology Unit (AMU) in developing a database of nights that experienced rapid (< 90 minutes) low cloud formation in a stable atmosphere, resulting in ceilings at the Shuttle Landing Facility (TTS) that violated Space Shuttle Flight Rules (FR). This work is the second phase of a similar AMU task that examined the same phenomena during the day. In the first phase of this work, the meteorological conditions favoring the rapid formation of low ceilings include the presence of any inversion below 8000 ft, high relative humidity (RH) beneath the inversion and a clockwise turning of the winds from the surface to the middle troposphere (-15000 ft). The AMU compared and contrasted the atmospheric and thermodynamic conditions between nights with rapid low ceiling formation and nights with low ceilings resulting from other mechanisms. The AMU found that there was little to discern between the rapidly-forming ceiling nights and other low ceiling nights at TTS. When a rapid development occurred, the average RH below the inversions was 87% while non-events had an average RH of 79%. One key parameter appeared to be the vertical wind profile in the Cape Canaveral, FL radiosonde (XMR) sounding. Eighty-three percent of the rapid development events had veering winds with height from the surface to the middle troposphere (-15,000 ft) while 61% of the non-events had veering winds with height. Veering winds indicate a warm-advection regime, which supports large-scale rising motion and ultimately cloud formation in a moist environment. However, only six of the nights (out of 86 events examined) with low cloud ceilings had an occurrence of rapidly developing ceilings. Since only 7% rapid development events were observed in this dataset, it is likely that rapid low cloud development is not a common occurrence during the night, or at least not as common as during the day. In the AMU work on the daytime rapid low cloud development (Case and Wheeler 2005), nearly 30% of the low cloud ceiling cases investigated were identified as rapidly developing events. Forecasters at the Space Meteorology Group (SMG) issue 30 to 90 minute forecasts for low cloud ceilings at TTS to support Space Shuttle landings. Mission verification statistics have shown ceilings to be the number one forecast challenge. More specifically, forecasters at SMG are concerned with any rapidly developing clouds/ceilings below 8000 R in a stable, capped thermodynamic environment. Therefore, the AMU was tasked to examine archived events of rapid stable cloud formation resulting in ceilings below 8000 ft, and document the atmospheric regimes favoring this type of cloud development. The AMU examined the cool season months of November to March during the years of 1994-2005 for nights that had low-level inversions and rapid, stable low cloud formation that resulted in ceilings violating the Space Shuttle FR. The AMU wrote and modified existing code to identify inversions from the evening and morning XMR radiosonde during the cool season and output pertinent sounding information. They parsed all days with cloud ceilings below 8000 ft at TTS, forming a database of possible rapidly-developing low ceiling events. Nights with precipitation or noticeable fog burn-off situations were excluded from the database. Only the nighttime hours were examined for possible ceiling development events since the daytime events were examined in the first phase of this work. The report presents one sample case of rapidly-developing low cloud ceilings. The case depicts the representative meteorological and thermodynamic characteristics of such events. The case also illustrates how quickly the cloud decks can develop, sometimes forming in 30 minutes or less. The report also summarizes the composite meteorological conditions for 6 event nights with rapid low cloud ceiling formation and 80 non-events nights consisting of advection or widespread low cloud ceilings. The teorological conditions were quite similar for both the event and non-event nights, since both types of nights experienced low cloud ceilings. Both types of nights had a relatively moist environment beneath an inversion based below 8000 ft.

Integrating Wind Profiling Radars and Radiosonde Observations with Model Point Data to Develop a Decision Support Tool to Assess Upper-Level Winds for Space Launch

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Flinn, Clay

2013-01-01

On the day-of-launch, the 45th Weather Squadron (45 WS) Launch Weather Officers (LWOs) monitor the upper-level winds for their launch customers to include NASA's Launch Services Program and NASA's Ground Systems Development and Operations Program. They currently do not have the capability to display and overlay profiles of upper-level observations and numerical weather prediction model forecasts. The LWOs requested the Applied Meteorology Unit (AMU) develop a tool in the form of a graphical user interface (GUI) that will allow them to plot upper-level wind speed and direction observations from the Kennedy Space Center (KSC) 50 MHz tropospheric wind profiling radar, KSC Shuttle Landing Facility 915 MHz boundary layer wind profiling radar and Cape Canaveral Air Force Station (CCAFS) Automated Meteorological Processing System (AMPS) radiosondes, and then overlay forecast wind profiles from the model point data including the North American Mesoscale (NAM) model, Rapid Refresh (RAP) model and Global Forecast System (GFS) model to assess the performance of these models. The AMU developed an Excel-based tool that provides an objective method for the LWOs to compare the model-forecast upper-level winds to the KSC wind profiling radars and CCAFS AMPS observations to assess the model potential to accurately forecast changes in the upperlevel profile through the launch count. The AMU wrote Excel Visual Basic for Applications (VBA) scripts to automatically retrieve model point data for CCAFS (XMR) from the Iowa State University Archive Data Server (http://mtarchive.qeol.iastate.edu) and the 50 MHz, 915 MHz and AMPS observations from the NASA/KSC Spaceport Weather Data Archive web site (http://trmm.ksc.nasa.gov). The AMU then developed code in Excel VBA to automatically ingest and format the observations and model point data in Excel to ready the data for generating Excel charts for the LWO's. The resulting charts allow the LWOs to independently initialize the three models 0-hour forecasts against the observations to determine which is the best performing model and then overlay the model forecasts on time-matched observations during the launch countdown to further assess the model performance and forecasts. This paper will demonstrate integration of observed and predicted atmospheric conditions into a decision support tool and demonstrate how the GUI is implemented in operations.

Vandenberg Air Force Base Upper Level Wind Launch Weather Constraints

NASA Technical Reports Server (NTRS)

Shafer, Jaclyn A.; Wheeler, Mark M.

2012-01-01

The 30th Operational Support Squadron Weather Flight (30 OSSWF) provides comprehensive weather services to the space program at Vandenberg Air Force Base (VAFB) in California. One of their responsibilities is to monitor upper-level winds to ensure safe launch operations of the Minuteman III ballistic missile. The 30 OSSWF tasked the Applied Meteorology Unit (AMU) to analyze VAFB sounding data with the goal of determining the probability of violating (PoV) their upper-level thresholds for wind speed and shear constraints specific to this launch vehicle, and to develop a tool that will calculate the PoV of each constraint on the day of launch. In order to calculate the probability of exceeding each constraint, the AMU collected and analyzed historical data from VAFB. The historical sounding data were retrieved from the National Oceanic and Atmospheric Administration Earth System Research Laboratory archive for the years 1994-2011 and then stratified into four sub-seasons: January-March, April-June, July-September, and October-December. The maximum wind speed and 1000-ft shear values for each sounding in each subseason were determined. To accurately calculate the PoV, the AMU determined the theoretical distributions that best fit the maximum wind speed and maximum shear datasets. Ultimately it was discovered that the maximum wind speeds follow a Gaussian distribution while the maximum shear values follow a lognormal distribution. These results were applied when calculating the averages and standard deviations needed for the historical and real-time PoV calculations. In addition to the requirements outlined in the original task plan, the AMU also included forecast sounding data from the Rapid Refresh model. This information provides further insight for the launch weather officers (LWOs) when determining if a wind constraint violation will occur over the next few hours on day of launch. The interactive graphical user interface (GUI) for this project was developed in Microsoft Excel using Visual Basic for Applications. The GUI displays the critical sounding data easily and quickly for the LWOs on day of launch. This tool will replace the existing one used by the 30 OSSWF, assist the LWOs in determining the probability of exceeding specific wind threshold values, and help to improve the overall upper winds forecast for the launch customer.

Technetium-99 cycling in maple trees: characterization of changes in chemical form.

PubMed

Garten, C T; Lomax, R D

1989-08-01

Prior field studies near an old radioactive waste disposal site at Oak Ridge, TN, indicated that following root uptake, metabolism by deciduous trees rendered 99Tc less biogeochemically mobile than expected, based on chemistry of the pertechnetate (TcO-4) anion. Subsequently, the form of technetium (Tc) in maple tree (Acer sp.) sap, leaves, wood and forest leaf litter was characterized using one or more of the following methods: dialysis, physical fractionation, chemical extraction, gel permeation chromatography, enzymatic extraction, or thin layer chromatography (TLC) on silica gel. Chromatography (Sephadex G-25) of TcO-4 incubated in vitro with tree sap showed it to behave similar to TcO-4 anion. When labeled wood and leaf tissues were processed using a tissue homogenizer, 15% and 40%, respectively, of the Tc was solubilized into phosphate buffer. Most (65% to 80%) of the solubilized Tc passing a 0.45-micron filter also passed through an ultrafiltration membrane with a nominal molecular weight cutoff of 10,000 atomic mass units (amu). A majority (72% to 80%) of the Tc in wood could be chemically removed by successive extractions with ethanol, water and weak mineral acid. These same extractants removed only 23% to 31% of the Tc from maple leaves or forest floor leaf litter. Most of the Tc in leaves and leaf litter was removed only by strongly alkaline reagents typically used to release structural polysaccharides (hemicelluloses) from plant tissues. Chromatography (Sephadex G-25) of the ethanol-water extract from wood and the alkaline extract from leaves demonstrated that Tc in these extracts was not principally TcO-4 but was complexed with molecules greater than 1000 amu. Incubations of leaf and wood homogenates with protease approximately doubled the amount of Tc released from contaminated tissues. Ultrafiltration of protease-solubilized Tc from leaves and wood showed that 40% and 93%, respectively, of the Tc was less than 10,000 amu. TLC of the less than 10,000 amu fraction indicated the presence of TcO-4 in wood but not in leaves. In the leaf, TcO-4 is converted to less soluble forms apparently associated with structural components of leaf cell walls. This conversion explains why 99Tc is not easily leached by rainfall from tree foliage and why 99Tc appears to accumulate in forest floor leaf litter layers at the Oak Ridge study site.

Displaying Composite and Archived Soundings in the Advanced Weather Interactive Processing System

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III; Volkmer, Matthew R.; Blottman, Peter F.; Sharp, David W.

2008-01-01

In a previous task, the Applied Meteorology Unit (AMU) developed spatial and temporal climatologies of lightning occurrence based on eight atmospheric flow regimes. The AMU created climatological, or composite, soundings of wind speed and direction, temperature, and dew point temperature at four rawinsonde observation stations at Jacksonville, Tampa, Miami, and Cape Canaveral Air Force Station, for each of the eight flow regimes. The composite soundings were delivered to the National Weather Service (NWS) Melbourne (MLB) office for display using the National version of the Skew-T Hodograph analysis and Research Program (NSHARP) software program. The NWS MLB requested the AMU make the composite soundings available for display in the Advanced Weather Interactive Processing System (AWIPS), so they could be overlaid on current observed soundings. This will allow the forecasters to compare the current state of the atmosphere with climatology. This presentation describes how the AMU converted the composite soundings from NSHARP Archive format to Network Common Data Form (NetCDF) format, so that the soundings could be displayed in AWl PS. The NetCDF is a set of data formats, programming interfaces, and software libraries used to read and write scientific data files. In AWIPS, each meteorological data type, such as soundings or surface observations, has a unique NetCDF format. Each format is described by a NetCDF template file. Although NetCDF files are in binary format, they can be converted to a text format called network Common data form Description Language (CDL). A software utility called ncgen is used to create a NetCDF file from a CDL file, while the ncdump utility is used to create a CDL file from a NetCDF file. An AWIPS receives soundings in Binary Universal Form for the Representation of Meteorological data (BUFR) format (http://dss.ucar.edu/docs/formats/bufr/), and then decodes them into NetCDF format. Only two sounding files are generated in AWIPS per day. One file contains all of the soundings received worldwide between 0000 UTC and 1200 UTC, and the other includes all soundings between 1200 UTC and 0000 UTC. In order to add the composite soundings into AWIPS, a procedure was created to configure, or localize, AWIPS. This involved modifying and creating several configuration text files. A unique fourcharacter site identifier was created for each of the 32 soundings so each could be viewed separately. The first three characters were based on the site identifier of the observed sounding, while the last character was based on the flow regime. While researching the localization process for soundings, the AMU discovered a method of archiving soundings so old soundings would not get purged automatically by AWl PS. This method could provide an alternative way of localizing AWl PS for composite soundings. In addition, this would allow forecasters to use archived soundings in AWIPS for case studies. A test sounding file in NetCDF format was written in order to verify the correct format for soundings in AWIPS. After the file was viewed successfully in AWIPS, the AMU wrote a software program in the Tool Command Language/Tool Kit (Tcl/Tk) language to convert the 32 composite soundings from NSHARP Archive to CDL format. The ncgen utility was then used to convert the CDL file to a NetCDF file. The NetCDF file could then be read and displayed in AWIPS.

Tower Mesonetwork Climatology and Interactive Display Tool

NASA Technical Reports Server (NTRS)

Case, Jonathan L.; Bauman, William H., III

2004-01-01

Forecasters at the 45th Weather Squadron and Spaceflight Meteorology Group use data from the tower network over the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) to evaluate Launch Commit Criteria, and issue and verify forecasts for ground operations. Systematic biases in these parameters could adversely affect an analysis, forecast, or verification. Also, substantial geographical variations in temperature and wind speed can occur under specific wind directions. To address these concerns, the Applied Meteorology Unit (AMU) developed a climatology of temperatures and winds from the tower network, and identified the geographical variation and significant tower biases. The mesoclimate is largely driven by the complex land-water interfaces across KSC/CCAFS. Towers with close proximity to water typically had much warmer nocturnal temperatures and higher wind speeds throughout the year. The strongest nocturnal wind speeds occurred from October to March whereas the strongest mean daytime wind speeds occurred from February to May. These results of this project can be viewed by forecasters through an interactive graphical user interface developed by the AMU. The web-based interface includes graphical and map displays of mean, standard deviation, bias, and data availability for any combination of towers, variables, months, hours, and wind directions.

Negative Ion Chemistry in the Coma of Comet 1P/Halley

NASA Technical Reports Server (NTRS)

Cordiner, M. A.; Charnley, S. B.

2012-01-01

Negative ions (anions) were identified in the coma of comet 1P/Halley from in-situ measurements performed by the Giotto spacecraft in 1986. These anions were detected with masses in the range 7-110 amu, but with insufficient mass resolution to permit unambiguous identification. We present details of a new chemical-hydrodynamic model for the coma of comet Halley that includes - for the first time - atomic and molecular anions, in addition to a comprehensive hydrocarbon chemistry. Anion number densities arc calculated as a function of radius in the coma, and compared with the Giotto results. Important anion production mechanisms arc found to include radiative electron attachment, polar photodissociation, dissociative electron attachment, and proton transfer. The polyyne anions C4H(-) and C6H(-) arc found to be likely candidates to explain the Giotto anion mass spectrum in the range 49-73 amu. Thc CN(-) anion probably makes a significant contribution to the mass spectrum at 26 amu. Larger carbon-chain anions such as C8H(1) can explain the peak near 100 amu provided there is a source of large carbon-chain-bearing molecules from the cometary nucleus.

Mesozoic evolution of the Amu Darya basin

NASA Astrophysics Data System (ADS)

Brunet, Marie-Françoise; Ershov, Andrey; Korotaev, Maxim; Mordvintsev, Dmitriy; Barrier, Eric; Sidorova, Irina

2014-05-01

This study, granted by the Darius Programme, aims at proposing a model of tectono-stratigraphic evolution of the Amu Darya basin since the Late Palaeozoic and to understand the relationship with the nearby basins. The Amu Darya basin, as its close eastern neighbour, the Afghan-Tajik basin, lies on the Turan platform, after the closure of the Turkestan Ocean during the Late Paleozoic. These two basins, spread on mainly lowlands of Turkmenistan, southwest Uzbekistan, Tajikistan, and northern Afghanistan, are separated from one another by the South-Western Gissar meganticline, where series of the northern Amu Darya margin are outcropping. The evolution is closely controlled by several periods of crustal thinning (post-collision rifting and back-arc extension), with some marine incursions, coming in between accretions of continental blocks and collisions that succeeded from the Late Triassic-Early Jurassic (Eo-Cimmerian orogeny) to the Cenozoic times. These orogenies controlled the deposition of thick clastics sequences, and the collision of the Indian Plate with Eurasia strongly deformed the sedimentary cover of the Afghan-Tajik basin. The more than 7 km thick Meso-Cenozoic sedimentary succession of the Amu Darya basin, lies on a complex system of rifts and blocks. Their orientation and age (late Permian, Triassic?) are not well known because of deep burial. The north-eastern margin, with the Bukhara (upper margin) and Chardzhou steps, is NW oriented, parallel to the Paleozoic Turkestan suture. The orientation bends to W-E, in the part of the Gissar situated to the North of the Afghan-Tajik basin. This EW trending orientation prevails also in the south(-eastern) margin of the basin (series of North Afghanistan highs) and in the Murgab depression, the south-eastern deepest portion of the Amu Darya basin. It is in this area and in the eastern part of the Amu Darya basin that the Jurassic as well as the lower Cretaceous sediments are the thickest. The south-western part of the basin is occupied by the Pre-Kopet Dagh Cenozoic foreland basin NW oriented, possibly underlain by an earlier extensional trough. The main elements of the sedimentary pile, which can be partly observed in the South-Western Gissar are: Lower to Middle Jurassic continental to paralic clastic rocks; upper Middle to Upper Jurassic marine carbonate then thick Tithonian evaporite rocks, sealing the reservoirs in the Jurassic carbonates; continental Neocomian clastic rocks and red beds, Aptian to Paleogene marine carbonate and clastic rocks. To reconstruct the geodynamic evolution of the Amu Darya Basin, we analysed the subsidence by backstripping of some wells/pseudo-wells and of three cross-sections with some examples of thermal modelling on the periods of maturation of the potential source rocks. The crustal thinning events take place in the Permo-Triassic? (depending on the age of the rifts underlying the basin), in Early-Middle Jurassic and during the Early Cretaceous, resulting in increases of the tectonic subsidence rates.

Isolation and characterization of DM40 and DM43, two snake venom metalloproteinase inhibitors from Didelphis marsupialis serum.

PubMed

Neves-Ferreira, A G; Cardinale, N; Rocha, S L; Perales, J; Domont, G B

2000-05-01

From Didelphis marsupialis serum, two antihemorrhagic proteins were isolated by DEAE-Sephacel, Phenyl-Sepharose and Superdex 200 and characterized. Their masses by mass spectrometry were 40318 AMU for DM40 and 42373 and 43010 AMU for DM43, indicating the presence of isoforms for the last. Molecular masses of 44.8 and 47.3 were obtained by SDS-PAGE, respectively for DM40 and DM43. Both inhibitors showed isoelectric points lower than 3.5 and glycosylation percentages varying from 20.5 to 29.0%, as estimated by chemical deglycosylation and amino acid analysis. N-terminal sequences of the first 17 residues of DM40 and DM43 were identical except for the exchange of R9 for P9. Both were homologous to oprin, a similar inhibitor from Didelphis virginiana serum. No evidence of complex formation between DM40 and DM43 was observed either by native PAGE or gel filtration chromatography. In addition to the antihemorrhagic activity, DM40 and DM43 inhibited the hydrolysis of casein, fibrinogen and fibronectin by Bothrops jararaca venom. DM43 also showed antilethal, antiedematogenic and antihyperalgesic activities. None of the inhibitors showed enzymatic activity on casein. Both proteins formed stable complexes with jararhagin and inhibited its hemorrhagic effect as well as the enzymatic activity of this toxin on fluorogenic substrate.

The Energetic Particles Acceleration, Composition, and Transport (EPACT) experiment on the ISTP/wind spacecraft

NASA Technical Reports Server (NTRS)

Reames, D. V.; Von Rosenvinge, T. T.; Ramaty, R.; Mason, G. M.; Hamilton, D. C.; Forman, M. A.; Webber, W. R.

1990-01-01

The EPACT experiment will measure abundances, spectra, and angular distributions of particles from 20 keV/amu to 500 MeV/amu. At high energies, isotopes will be resolved up through Z = 26, at intermediate energies elements with Z between 1 and 82 will be observed, and at low energies element abundances above Z = 2 will be resolved for the first time.

Statistical Short-Range Forecast Guidance for Cloud Ceilings Over the Shuttle Landing Facility

NASA Technical Reports Server (NTRS)

Lambert, Winifred C.

2001-01-01

This report describes the results of the AMU's Short-Range Statistical Forecasting task. The cloud ceiling forecast over the Shuttle Landing Facility (SLF) is a critical element in determining whether a Shuttle should land. Spaceflight Meteorology Group (SMG) forecasters find that ceilings at the SLF are challenging to forecast. The AMU was tasked to develop ceiling forecast equations to minimize the challenge. Studies in the literature that showed success in improving short-term forecasts of ceiling provided the basis for the AMU task. A 20-year record of cool-season hourly surface observations from stations in east-central Florida was used for the equation development. Two methods were used: an observations-based (OBS) method that incorporated data from all stations, and a persistence climatology (PCL) method used as the benchmark. Equations were developed for 1-, 2-, and 3-hour lead times at each hour of the day. A comparison between the two methods indicated that the OBS equations performed well and produced an improvement over the PCL equations. Therefore, the conclusion of the AMU study is that OBS equations produced more accurate forecasts than the PCL equations, and can be used in operations. They provide another tool with which to make the ceiling forecasts that are critical to safe Shuttle landings at KSC.

“SHOUT” to improve the quality of care delivered to patients with acute kidney injury at Great Western Hospital

PubMed Central

Brady, Paul; Gorham, James; Kosti, Angeliki; Seligman, William; Courtney, Alona; Mazan, Karolina; Paterson, Stuart; Ramcharitar, Steve; Chandrasekaran, Badri; Juniper, Mark; Greamspet, Mala; Daniel, Jessica; Chalstrey, Sue; Ahmed, Ijaz; Dasgupta, Tanaji

2015-01-01

Acute kidney injury (AKI) affects up to 20% of all patients admitted to hospital, and is associated with a higher risk of adverse clinical outcomes, increased healthcare costs, as well as long term risks of chronic kidney disease and end stage renal failure. The aim of this project was to improve the quality of care for patients with AKI admitted to the acute medical unit (AMU) at the Great Western Hospital (GWH). We assessed awareness and self reported confidence among physicians in our Trust, in addition to basic aspects of care relevant to AKI on our AMU. A multifaceted quality improvement strategy was developed, which included measures to improve awareness such as a Trust wide AKI awareness day, and reconfiguring the admission proforma on our AMU in order to enhance risk assessment, staging, and early response to AKI. Ancillary measures such as the dissemination of flashcards for lanyards containing core information were also used. Follow up assessments showed that foundation year one (FY1) doctors’ self reported confidence in managing AKI increased from 2.8 to 4.2, as measured on a five point Likert scale (P=0.0003). AKI risk assessment increased from 13% to 57% (P=0.07) following a change in the admission proforma. Documentation of the diagnosis of AKI increased from 66% to 95% (P=0.038) among flagged patients. Documentation of urine dip results increased from 33% to 73% (P=0.01), in addition to a rise in appropriate referral for specialist input, although this was not statistically significant. Our results suggest that using the twin approaches of improving awareness, and small changes to systemic factors such as modification of the admission proforma, can lead to significant enhancements in the quality of care of patients with AKI. PMID:26734401

The analysis of rapidly developing fog at the Kennedy Space Center

NASA Technical Reports Server (NTRS)

Wheeler, Mark M.; Atchison, Michael K.; Schumann, Robin; Taylor, Greg E.; Yersavich, Ann; Warburton, John D.

1994-01-01

This report documents fog precursors and fog climatology at Kennedy Space Center (KSC) Florida from 1986 to 1990. The major emphasis of this report focuses on rapidly developing fog events that would affect the less than 7-statute mile visibility rule for End-Of-Mission (EOM) Shuttle landing at KSC (Rule 4-64(A)). The Applied Meteorology Unit's (AMU's) work is to: develop a data base for study of fog associated weather conditions relating to violations of this landing constraint; develop forecast techniques or rules-of-thumb to determine whether or not current conditions are likely to result in an acceptable condition at landing; validate the forecast techniques; and transition techniques to operational use. As part of the analysis the fog events were categorized as either advection, pre-frontal or radiation. As a result of these analyses, the AMU developed a fog climatological data base, identified fog precursors and developed forecaster tools and decision trees. The fog climatological analysis indicates that during the fog season (October to April) there is a higher risk for a visibility violation at KSC during the early morning hours (0700 to 1200 UTC), while 95 percent of all fog events have dissipated by 1600 UTC. A high number of fog events are characterized by a westerly component to the surface wind at KSC (92 percent) and 83 percent of the fog events had fog develop west of KSC first (up to 2 hours). The AMU developed fog decision trees and forecaster tools that would help the forecaster identify fog precursors up to 12 hours in advance. Using the decision trees as process tools ensures the important meteorological data are not overlooked in the forecast process. With these tools and a better understanding of fog formation in the local KSC area, the Shuttle weather support forecaster should be able to give the Launch and Flight Directors a better KSC fog forecast with more confidence.

Workstation-Based Real-Time Mesoscale Modeling Designed for Weather Support to Operations at the Kennedy Space Center and Cape Canaveral Air Station

NASA Technical Reports Server (NTRS)

Manobianco, John; Zack, John W.; Taylor, Gregory E.

1996-01-01

This paper describes the capabilities and operational utility of a version of the Mesoscale Atmospheric Simulation System (MASS) that has been developed to support operational weather forecasting at the Kennedy Space Center (KSC) and Cape Canaveral Air Station (CCAS). The implementation of local, mesoscale modeling systems at KSC/CCAS is designed to provide detailed short-range (less than 24 h) forecasts of winds, clouds, and hazardous weather such as thunderstorms. Short-range forecasting is a challenge for daily operations, and manned and unmanned launches since KSC/CCAS is located in central Florida where the weather during the warm season is dominated by mesoscale circulations like the sea breeze. For this application, MASS has been modified to run on a Stardent 3000 workstation. Workstation-based, real-time numerical modeling requires a compromise between the requirement to run the system fast enough so that the output can be used before expiration balanced against the desire to improve the simulations by increasing resolution and using more detailed physical parameterizations. It is now feasible to run high-resolution mesoscale models such as MASS on local workstations to provide timely forecasts at a fraction of the cost required to run these models on mainframe supercomputers. MASS has been running in the Applied Meteorology Unit (AMU) at KSC/CCAS since January 1994 for the purpose of system evaluation. In March 1995, the AMU began sending real-time MASS output to the forecasters and meteorologists at CCAS, Spaceflight Meteorology Group (Johnson Space Center, Houston, Texas), and the National Weather Service (Melbourne, Florida). However, MASS is not yet an operational system. The final decision whether to transition MASS for operational use will depend on a combination of forecaster feedback, the AMU's final evaluation results, and the life-cycle costs of the operational system.

Constraining heating processes in the solar wind with kinetic properties of heavy ions

NASA Astrophysics Data System (ADS)

Kasper, J. C.; Tracy, P.; Zurbuchen, T.; Raines, J. M.; Gilbert, J. A.; Shearer, P.

2016-12-01

Heavy ion components (A > 4 amu) in collisionally young solar wind plasma show a clear, stable dependence of temperature on mass, probably reflecting the conditions in the solar corona. Using results from the Solar Wind Ion Composition Spectrometer (SWICS) onboard the Advanced Composition Explorer (ACE), we find that the heavy ion temperatures are well organized by a simple linear fit of the form Ti/Tp=(1.35+/- .02) mi/mp. Most importantly we find that the current model predictions based on turbulent transport and kinetic dissipation are in agreement with observed nonthermal heating in intermediate collisional age plasma for m/q < 3.5 amu/e, but are not in quantitative or qualitative agreement with the lowest collisional age results. These dependencies provide new constraints on the physics of ion heating in multispecies plasma, along with predictions to be tested by the upcoming Solar Probe Plus and Solar Orbiter missions to the near-Sun environment.

Flow Regime Based Climatologies of Lightning Probabilities for Spaceports and Airports

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Sharp, David; Spratt, Scott; Lafosse, Richard A.

2008-01-01

The objective of this work was to provide forecasters with a tool to indicate the warm season climatological probability of one or more lightning strikes within a circle at a site within a specified time interval. This paper described the AMU work conducted in developing flow regime based climatologies of lightning probabilities for the SLF and seven airports in the NWS MLB CWA in east-central Florida. The paper also described the GUI developed by the AMU that is used to display the data for the operational forecasters. There were challenges working with gridded lightning data as well as the code that accompanied the gridded data. The AMU modified the provided code to be able to produce the climatologies of lightning probabilities based on eight flow regimes for 5-, 10-, 20-, and 30-n mi circles centered on eight sites in 1-, 3-, and 6-hour increments.

New calculations and measurements of the Coulomb cross-section for the production of direct electron pairs by high energy nuclei

NASA Technical Reports Server (NTRS)

Derrickson, J. H.; Dake, S.; Dong, B. L.; Eby, P. B.; Fountain, W. F.; Fuki, M.; Gregory, J. C.; Hayashi, T.; Iyono, A.; King, D. T.

1989-01-01

Recently, new calculations were made of the direct Coulomb pair cross section that rely less in arbitrary parameters. More accurate calculations of the cross section down to low pair energies were made. New measurements of the total direct electron pair yield, and the energy and angular distribution of the electron pairs in emulsion were made for O-16 at 60 and 200 GeV/amu at S-32 at 200 GeV/amu which give satisfactory agreement with the new calculations. These calculations and measurements are presented along with previous accelerator measurements made of this effect during the last 40 years. The microscope scanning criteria used to identify the direct electron pairs is described. Prospects for application of the pair method to cosmic ray energy measurements in the region 10 (exp 13) to 10 (exp 15) eV/amu are discussed.

The Muon $g$-$2$ Experiment at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gohn, Wesley

A new measurement of the anomalous magnetic moment of the muon,more » $$a_{\\mu} \\equiv (g-2)/2$$, will be performed at the Fermi National Accelerator Laboratory with data taking beginning in 2017. The most recent measurement, performed at Brookhaven National Laboratory (BNL) and completed in 2001, shows a 3.5 standard deviation discrepancy with the standard model value of $$a_\\mu$$. The new measurement will accumulate 21 times the BNL statistics using upgraded magnet, detector, and storage ring systems, enabling a measurement of $$a_\\mu$$ to 140 ppb, a factor of 4 improvement in the uncertainty the previous measurement. This improvement in precision, combined with recent improvements in our understanding of the QCD contributions to the muon $g$-$2$, could provide a discrepancy from the standard model greater than 7$$\\sigma$$ if the central value is the same as that measured by the BNL experiment, which would be a clear indication of new physics.« less

Impact of Local Sensors

NASA Technical Reports Server (NTRS)

Watson, Leela R.; Bauman, William H., III

2008-01-01

Forecasters at the 45th Weather Squadron (45 WS) use observations from the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) wind tower network and the CCAFS (XMR) daily rawinsonde observations (RAOB) to issue and verify wind advisories and warnings for operations. These observations are also used by the National Weather Service (NWS) Spaceflight Meteorology Group (SMG) in Houston, Texas and the NWS Melbourne, Florida (NWS MLB) to initialize their locally-run mesoscale models. In addition, SMG uses these observations to support shuttle landings at the Shuttle Landing Facility (SLF). Due to impending budget cuts, some or all of the KSC/CCAFS wind towers on the east-central Florida mainland and the XMR RAOBs may be eliminated. The locations of the mainland towers and XMR RAOB site are shown in Figure I. The loss of these data may impact the forecast capability of the 45 WS, SMG and NWS MLB. The AMU was tasked to conduct an objective independent modeling study to help determine how important these observations are to the accuracy of the model output used by the forecasters. To accomplish this, the Applied Meteorology Unit (AMU) performed a sensitivity study using the Weather Research and Forecasting (WRF) model initialized with and without KSC/CCAFS wind tower and XMR RAOB data.

Verification and implementation of microburst day potential index (MDPI) and wind INDEX (WINDEX) forecasting tools at Cape Canaveral Air Station

NASA Technical Reports Server (NTRS)

Wheeler, Mark

1996-01-01

This report details the research, development, utility, verification and transition on wet microburst forecasting and detection the Applied Meteorology Unit (AMU) did in support of ground and launch operations at Kennedy Space Center (KSC) and Cape Canaveral Air Station (CCAS). The unforecasted wind event on 16 August 1994 of 33.5 ms-1 (65 knots) at the Shuttle Landing Facility raised the issue of wet microburst detection and forecasting. The AMU researched and analyzed the downburst wind event and determined it was a wet microburst event. A program was developed for operational use on the Meteorological Interactive Data Display System (MIDDS) weather system to analyze, compute and display Theta(epsilon) profiles, the microburst day potential index (MDPI), and wind index (WINDEX) maximum wind gust value. Key microburst nowcasting signatures using the WSR-88D data were highlighted. Verification of the data sets indicated that the MDPI has good potential in alerting the duty forecaster to the potential of wet microburst and the WINDEX values computed from the hourly surface data do have potential in showing a trend for the maximum gust potential. WINDEX should help in filling in the temporal hole between the MDPI on the last Cape Canaveral rawinsonde and the nowcasting radar data tools.

Analysis of trace levels of sulfonamide and tetracycline antimicrobials in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry

USGS Publications Warehouse

Lindsey, M.E.; Meyer, M.; Thurman, E.M.

2001-01-01

A method has been developed for the trace analysis of two classes of antimicrobials consisting of six sulfonamides (SAs) and five tetracyclines (TCs), which commonly are used for veterinary purposes and agricultural feed additives and are suspected to leach into ground and surface water. The method used solid-phase extraction and liquid chromatography/mass spectrometry (LC/MS) with positive ion electrospray. The unique combination of a metal chelation agent (Na2EDTA) with a macroporous copolymer resulted in quantitative recoveries by solid-phase extraction (mean recovery, 98 ?? 12%) at submicrogram-per-liter concentrations. An ammonium formate/formic acid buffer with a methanol/water gradient was used to separate the antimicrobials and to optimize the signal intensity. Mass spectral fragmentation and ionization characteristics were determined for each class of compounds for unequivocal identification. For all SAs, a characteristic m/z 156 ion representing the sulfanilyl fragment was identified. TCs exhibited neutral losses of 17 amu resulting from the loss of ammonia and 35 amu from the subsequent loss of water. Unusual matrix effects were seen only for TCs in this first survey of groundwater and surface water samples from sites around the United States, requiring that TCs be quantitated using the method of standard additions.

High-Resolution Analysis Products to Support Severe Weather and Cloud-to-Ground Lightning Threat Assessments over Florida

NASA Technical Reports Server (NTRS)

Case, Jonathan; Spratt, Scott; Sharp, David

2006-01-01

The Applied Meteorology Unit (AMU) located at the Kennedy Space Center (KSC)/Cape Canaveral Air Force Station (CCAFS) implemented an operational configuration of the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS), as well as the ARPS numerical weather prediction (NWP) model. Operational, high-resolution ADAS analyses have been produced from this configuration at the National Weather Service in Melbourne, FL (NWS MLB) and the Spaceflight Meteorology Group (SMG) over the past several years. Since that time, ADAS fields have become an integral part of forecast operations at both NWS MLB and SMG. To continue providing additional utility, the AMU has been tasked to implement visualization products to assess the potential for supercell thunderstorms and significant tornadoes, and to improve assessments of short-term cloud-to-ground (CG) lightning potential. This paper and presentation focuses on the visualization products developed by the AMU for the operational high-resolution ADAS and AR.PS at the NWS MLB and SMG. The two severe weather threat graphics implemented within ADAS/ARPS are the Supercell Composite Parameter (SCP) and Significant Tornado Parameter (SIP). The SCP was designed to identify areas with supercell thunderstorm potential through a combination of several instability and shear parameters. The SIP was designed to identify areas that favor supercells producing significant tornadoes (F2 or greater intensity) versus non-tornadic supercells. Both indices were developed by the NOAAINWS Storm Prediction Center (SPC) and were normalized by key threshold values based on previous studies. The indices apply only to discrete storms, not other convective modes. In a post-analysis mode, the AMU calculated SCP and SIP for graphical output using an ADAS configuration similar to the operational set-ups at NWS MLB and SMG. Graphical images from ADAS were generated every 15 minutes for 13 August 2004, the day that Hurricane Charley approached and made landfall on the Florida peninsula. Several tornadoes struck the interior of the Florida peninsula in advance of Hurricane Charley's landfall during the daylight hours of 13 August. Since SPC had previously examined this case using SCP and SIP graphics generated from output of the Rapid Update Cycle (RUC) model, this day served as a good benchmark to compare and validate the high-resolution ADAS graphics against the smoother RUC analyses, which serves as background fields to the ADAS analyses. The ADAS-generated SCP and STP graphics have been integrated into the suite of products examined operationally by NWS MLB forecasters and are used to provide additional guidance for assessment of the near-storm environment during convective situations.

30 WS North Base Wind Study

NASA Technical Reports Server (NTRS)

Wheeler, Mark

2011-01-01

The 30 Weather Squadron (30 WS) is concerned about strong winds observed at their northern towers without advance warning. They state that terrain influences along the extreme northern fringes of Vandenberg Air Force Base (VAFB) make it difficult for forecasters to issue timely and accurate high wind warnings for northeasterly wind events. These events tend to occur during the winter or early spring when they are under the influence of the Great Basin high pressure weather regime. The Launch Weather Officers (LWOs) have seen these rapid wind increases in the current northern Towers 60, 70 and 71 in excess of their 35 kt operational warning threshold. For this task, the 30 WS requested the Applied Meteorology Unit (AMU) analyze data from days when these towers reported winds in excess of 35 kt and determine if there were any precursors in the observations that would allow the LWOs to better forecast and warn their operational customers for these wind events. The 30 WS provided wind tower data for the cool season (October - March) from the period January 2004-March 20 IO. The AMU decoded and evaluated the wind tower data for 66 days identified by the 30 WS as having high-wind events. Out of the 66 event days, only 30 had wind speed observations of > or =35 kt from at least one of the three northern towers. The AMU analyzed surface and upper air charts to determine the synoptic conditions for each event day along with tower peak wind speed and direction time series and wind rose charts for all 30 event days. The analysis revealed a trend on all event days in which the tower winds shifted to the northeast for a period of time before the first recorded > or =35 kt wind speed. The time periods for the 30 event days ranged from 20 minutes to several hours, with a median value of 110 minutes. This trend, if monitored, could give the 30 WS forecasters a precursor to assist in issuing an operational warning before a high wind event occurs. The AMU recommends developing a high-wind alert capability for VAFB using a local mesoscale model to forecast these wind events. The model should incorporate all of the VAFB local data sets and have a forecast capability of between 2 to 24 hours. Such a model would allow the meteorologists at VAFB to alert the operational customers of high wind events in a timely manner so protective action could be taken.

Economic and Geopolitical Integration between Morocco and Algeria

DTIC Science & Technology

2005-09-01

ACM: Arab Common Market AMU: Arab Maghreb Union ASEAN: Association of South East Asian Nations CAP: Common Agricultural Policy CSE...adopted, and an active agricultural policy helped develop the rural regions and limited the risk of massive urbanization. Algeria adopted a centralized...to protect members of the Union from the Moroccan competition. “The Common Agricultural Policy (CAP) remains the main obstacle towards wider access

Radiation Dose Assessments for Shore-Based Individuals in Operation Tomodachi, Revision 1

DTIC Science & Technology

2012-12-31

meter (m2) gallon (gal, U.S. liquid) 3.785 412 × 10–3 cubic meter (m3) cubic foot (ft3) 2.831 685 × 10–2 cubic meter (m3) Mass /Density pound (lb...4.535 924 × 10–1 kilogram (kg) atomic mass unit (AMU) 1.660 539 × 10–27 kilogram (kg) pound- mass per cubic foot (lb ft–3) 1.601 846 × 101 kilogram...Ridge, Inc., who provided peer review. • Dr. Mondher Chehata of SAIC who provided technical consultation and critical reviews of environmental

An unusual pathogen in ambulatory care: two cases of Scedosporium soft tissue infections presenting as "unresponsive cellulitis".

PubMed

Misselbrook, Gary Peter; Lillie, Patrick; Thomas, Claire P

2016-01-01

Soft tissue infections with Scedosporium spp. are an uncommon but serious and emerging cause of infection in immunocompromised patients. Acute Medical Units (AMUs) in the UK are increasingly managing patients with cellulitis in an outpatient setting, therefore acute physicians should be aware of some of the more uncommon causes of soft tissue infection, particularly in patients not responding to initial antibiotic therapy. We present two cases of Scedosporium presenting to the AMU as cellulitis not responding to initial antibiotic therapy and outline the assessment and management of this important condition.

The response of ionization chambers to relativistic heavy nuclei

NASA Technical Reports Server (NTRS)

Newport, B. J.; Stone, E. C.; Waddington, C. J.; Binns, W. R.; Fixsen, D. J.; Garrard, T. L.; Grimm, G.; Israel, M. H.; Klarmann, J.

1985-01-01

The LBL Bevalac for the Heavy Nuclei Experiment on HEAO-3, compared the response of a set of laboratory ionization chambers to beams of 26Fe, 36Kr, 54Xe, 67 Ho, and 79Au nuclei at maximum energies ranging from 1666 MeV/amu for Fe to 1049 MeV/amu for Au. The response of these chambers shows a significant deviation from the expected energy dependence, but only a slight deviation from Z sq scaling.

Survey of quantitative antimicrobial consumption per production stage in farrow-to-finish pig farms in Spain

PubMed Central

Moreno, Miguel A.

2014-01-01

Objectives To characterise antimicrobial use (AMU) per production stage in terms of drugs, routes of application, indications, duration and exposed animals in farrow-to-finish pig farms in Spain. Design Survey using a questionnaire on AMU during the six months prior to the interview, administered in face-to-face interviews completed from April to October 2010. Participants 108 potentially eligible farms covering all the country were selected using a multistage sampling methodology; of these, 33 were excluded because they did not fulfil the participation criteria and 49 were surveyed. Results The rank of the most used antimicrobials per farm and production stage and administration route started with polymyxins (colistin) by feed during the growing and the preweaning phases, followed by β-lactams by feed during the growing and the preweaning phases and by injection during the preweaning phase. Conclusions The study demonstrates that the growing stage (from weaning to the start of finishing) has the highest AMU according to different quantitative indicators (number of records, number of antimicrobials used, percentage of farms reporting use, relative number of exposed animals per farm and duration of exposure); feed is the administration route that produces the highest antimicrobial exposure based on the higher number of exposed animals and the longer duration of treatment; and there are large differences in AMU among individual pig farms. PMID:26392868

Low-energy electron-induced dissociation in condensed-phase L-cysteine II: a comparative study on anion desorption from chemisorbed and physisorbed films

NASA Astrophysics Data System (ADS)

Alizadeh, Elahe; Massey, Sylvain; Sanche, Léon; Rowntree, Paul A.

2016-04-01

Due to its multifunctional structure, cysteine is becoming an ideal model molecule for investigating the complex interactions of proteins with metallic surfaces such as gold nanoparticles. We report herein the results of low-energy electron induced degradation of L-cysteine films, chemisorbed on a gold substrate via the thiol group or physisorbed into a clean gold surface. The data were recorded under ultra-high vacuum conditions at room temperature. Anion yields desorbed from these films by the impact of 0.5 to 19 eV electrons provide clear evidence of the efficient decomposition of this amino acid via dissociative electron attachment (i.e., from dissociation of intermediate transient anions located between 5 and 14 eV). The peaks in the desorbed-anion yield functions, associated with DEA, are superimposed on a continuously rising signal attributed to dipolar dissociation. Similar to the results previously observed from physisorbed films, light anionic species, with masses lower than 35 amu, have been detected. In addition, we measured for first time fragments at 14 amu (CH2-) and 15 amu (CH3-) desorbing from physisorbed films, as well as heavier fragments of mass 45 and 46 amu desorbing from chemisorbed films. Contribution to the Topical Issue "Low-Energy Interactions related to Atmospheric and Extreme Conditions", edited by S. Ptasinska, M. Smialek-Telega, A. Milosavljevic, B. Sivaraman.

Evaluation of metrics for benchmarking antimicrobial use in the UK dairy industry.

PubMed

Mills, Harriet L; Turner, Andrea; Morgans, Lisa; Massey, Jonathan; Schubert, Hannah; Rees, Gwen; Barrett, David; Dowsey, Andrew; Reyher, Kristen K

2018-03-31

The issue of antimicrobial resistance is of global concern across human and animal health. In 2016, the UK government committed to new targets for reducing antimicrobial use (AMU) in livestock. Although a number of metrics for quantifying AMU are defined in the literature, all give slightly different interpretations. This paper evaluates a selection of metrics for AMU in the dairy industry: total mg, total mg/kg, daily dose and daily course metrics. Although the focus is on their application to the dairy industry, the metrics and issues discussed are relevant across livestock sectors. In order to be used widely, a metric should be understandable and relevant to the veterinarians and farmers who are prescribing and using antimicrobials. This means that clear methods, assumptions (and possible biases), standardised values and exceptions should be published for all metrics. Particularly relevant are assumptions around the number and weight of cattle at risk of treatment and definitions of dose rates and course lengths; incorrect assumptions can mean metrics over-represent or under-represent AMU. The authors recommend that the UK dairy industry work towards the UK-specific metrics using the UK-specific medicine dose and course regimens as well as cattle weights in order to monitor trends nationally. © British Veterinary Association (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey.

PubMed

Cai, Yiying; Venkatachalam, Indumathi; Tee, Nancy W; Tan, Thean Yen; Kurup, Asok; Wong, Sin Yew; Low, Chian Yong; Wang, Yang; Lee, Winnie; Liew, Yi Xin; Ang, Brenda; Lye, David C; Chow, Angela; Ling, Moi Lin; Oh, Helen M; Cuvin, Cassandra A; Ooi, Say Tat; Pada, Surinder K; Lim, Chong Hee; Tan, Jack Wei Chieh; Chew, Kean Lee; Nguyen, Van Hai; Fisher, Dale A; Goossens, Herman; Kwa, Andrea L; Tambyah, Paul A; Hsu, Li Yang; Marimuthu, Kalisvar

2017-05-15

We conducted a national point prevalence survey (PPS) to determine the prevalence of healthcare-associated infections (HAIs) and antimicrobial use (AMU) in Singapore acute-care hospitals. Trained personnel collected HAI, AMU, and baseline hospital- and patient-level data of adult inpatients from 13 private and public acute-care hospitals between July 2015 and February 2016, using the PPS methodology developed by the European Centre for Disease Prevention and Control. Factors independently associated with HAIs were determined using multivariable regression. Of the 5415 patients surveyed, there were 646 patients (11.9%; 95% confidence interval [CI], 11.1%-12.8%) with 727 distinct HAIs, of which 331 (45.5%) were culture positive. The most common HAIs were unspecified clinical sepsis (25.5%) and pneumonia (24.8%). Staphylococcus aureus (12.9%) and Pseudomonas aeruginosa (11.5%) were the most common pathogens implicated in HAIs. Carbapenem nonsusceptibility rates were highest in Acinetobacter species (71.9%) and P. aeruginosa (23.6%). Male sex, increasing age, surgery during current hospitalization, and presence of central venous or urinary catheters were independently associated with HAIs. A total of 2762 (51.0%; 95% CI, 49.7%-52.3%) patients were on 3611 systemic antimicrobial agents; 462 (12.8%) were prescribed for surgical prophylaxis and 2997 (83.0%) were prescribed for treatment. Amoxicillin/clavulanate was the most frequently prescribed (24.6%) antimicrobial agent. This survey suggested a high prevalence of HAIs and AMU in Singapore's acute-care hospitals. While further research is necessary to understand the causes and costs of HAIs and AMU in Singapore, repeated PPSs over the next decade will be useful to gauge progress at controlling HAIs and AMU. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA

PubMed Central

Bos, Marian E. H.; Verstappen, Koen M.; Van Cleef, Brigitte A. G. L.; Kluytmans, Jan A. J. W.; Wagenaar, Jaap A.; Heederik, Dick J. J.

2015-01-01

With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU) in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA). Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C)) was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07) and animals (p = 0.12 in first cycle)). These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend. PMID:26305895

Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA.

PubMed

Dorado-García, Alejandro; Graveland, Haitske; Bos, Marian E H; Verstappen, Koen M; Van Cleef, Brigitte A G L; Kluytmans, Jan A J W; Wagenaar, Jaap A; Heederik, Dick J J

2015-01-01

With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU) in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA). Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C)) was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07) and animals (p = 0.12 in first cycle)). These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend.

Observation of direct hadronic pairs in nucleus-nucleus collisions in JACEE emulsion chambers

NASA Technical Reports Server (NTRS)

Burnett, T. H.; Dake, S.; Fuki, M.; Gregory, J. C.; Hayashi, T.; Hayashi, T.; Holynski, R.; Iwai, J.; Jones, W. V.; Jurak, A.

1985-01-01

In a number of high energy ( or = 1 TeV/amu) nucleus-nucleus collisions observed in Japanese-American Cooperative Emulsion Experiment (JACEE) emulsion chambers, nonrandom spatial association of produced charged particles, mostly hadronic pairs, are observed. Similar narrow pairs are observed in about 100 events at much low energy (20 to 60 GeV/amu). Analysis shows that 30 to 50% of Pair abundances are understood by the Hambury-Brown-Twiss effect, and the remainder seems to require other explanations.

The response of ionization chambers to relativistic heavy nuclei

NASA Technical Reports Server (NTRS)

Newport, B. J.; Stone, E. C.; Waddington, C. J.; Binns, W. R.; Fixsen, D. J.; Garrard, T. L.; Grimm, G.; Israel, M. H.; Klarmann, J.

1985-01-01

As part of a recent calibration at the LBL Bevalac for the Heavy Nuclei Experiment on HEAO-3, the response of a set of laboratory ionization chambers were compared to beams of 26Fe, 36 Kr, 54Xe, 67 Ho, and 79 Au nuclei at maximum energies ranging from 1666 MeV/amu for Fe to 1049 MeV/amu for Au. The response of these chambers shows a significant deviation from the expected energy dependence, but only a slight deviation from Z squared scaling.

Target electron ionization in Li2+-Li collisions: A multi-electron perspective

NASA Astrophysics Data System (ADS)

Śpiewanowski, M. D.; Gulyás, L.; Horbatsch, M.; Kirchner, T.

2015-05-01

The recent development of the magneto-optical trap reaction-microscope has opened a new chapter for detailed investigations of charged-particle collisions from alkali atoms. It was shown that energy-differential cross sections for ionization from the outer-shell in O8+-Li collisions at 1500 keV/amu can be readily explained with the single-active-electron approximation. Understanding of K-shell ionization, however, requires incorporating many-electron effects. An ionization-excitation process was found to play an important role. We present a theoretical study of target electron removal in Li2+-Li collisions at 2290 keV/amu. The results indicate that in outer-shell ionization a single-electron process plays the dominant part. However, the K-shell ionization results are more difficult to interpret. On one hand, we find only weak contributions from multi-electron processes. On the other hand, a large discrepancy between experimental and single-particle theoretical results indicate that multi-electron processes involving ionization from the outer shell may be important for a complete understanding of the process. Work supported by NSERC, Canada and the Hungarian Scientific Research Fund.

Energy Calibration of the Scintillating Optical Fiber Calorimeter Chamber (SOFCAL)

NASA Technical Reports Server (NTRS)

Christl, M. C.; Fountain, W. F.; Parnell, T.; Roberts, F. E.; Gregory, J. C.; Johnson, J.; Takahashi, Y.

1997-01-01

The Scintillating Optical Fiber Calorimeter (SOFCAL) detector is designed to make direct measures of the primary cosmic ray spectrum from -200 GeV/amu - 20 TeV/amu. The primary particles are resolved into groups according to their charge (p, He, CNO, Medium Z, Heavy Z) using both active and passive components integrated into the detector. The principal part of SOFCAL is a thin ionization calorimeter that measures the electromagnetic cascades that result from these energetic particles interacting in the detector. The calorimeter is divided into two sections: a thin passive emulsion/x-ray film calorimeter, and a fiber calorimeter that uses crossing layers of small scintillating optical fibers to sample the energy deposition of the cascades. The energy determination is made by fitting the fiber data to transition curves generated by Monte Carlo simulations. The fiber data must first be calibrated using the electron counts from the emulsion plates in the calorimeter for a small number of events. The technique and results of this calibration will be presented together with samples of the data from a balloon flight.

Mastitis treatment-Reduction in antibiotic usage in dairy cows.

PubMed

Krömker, V; Leimbach, S

2017-08-01

Animal-friendly, economical, resource-saving milk production provides the basis for sustained consumer acceptance. Bovine mastitis plays a decisive role in the dairy industry-disturbing animal health and welfare and causing considerable economic losses on the other hand. Currently, antimicrobial treatment is indispensable to keep bovine udder health, animal welfare and economic aspects in balance. On the contrary, emergence and spread of antimicrobial resistance (AMR) is an urgent matter of particular public interest, and as a consequence, antimicrobial usage (AMU) in production livestock is a critically discussed subject. In urgent need of future reduction in AMU in the dairy industry, this review article describes and discusses possible approaches promising prompt implementation, including therapeutical alternatives as well as pro- and metaphylactic concepts such as the implementation of evidence-based mastitis therapy concepts and selective dry cow treatment (sDCT), in search of the most effective and contemporary methods for decreasing AMU and AMR in dairy production. © 2017 Blackwell Verlag GmbH.

Antimicrobials usage assessments in commercial poultry and local birds in North-central Nigeria: Associated pathways and factors for resistance emergence and spread.

PubMed

Alhaji, N B; Haruna, A E; Muhammad, B; Lawan, M K; Isola, T O

2018-06-01

The World Health Organization's Global Action Plan on antimicrobial resistance (AMR) recommended monitoring of antimicrobial use (AMU) through surveillance and research to help mitigate AMR. This survey was aimed at assessing poultry owners' knowledge/awareness and practices regarding AMU, identified pathways for AMR emergence and spread in small-scale commercial poultry farms and free-range local bird flocks in North-central Nigeria. An interview questionnaire-based cross-sectional study was conducted on commercial poultry farmers and local bird flock keepers in 2017. Also, a Traffic Light system model was used assess risk status of AMU in farms and flocks. All the 384 recruited poultry farmers/keepers participated in the survey. Female respondents were the majority (67.2%). Low proportion of poultry farmers (46.4%, 89/192) and very low proportion of bird keepers (6.8%, 13/192) knew antimicrobials misuse to be when administered under dose. About 48% (93/192) of farmers and 93% (179/192) of keepers arbitrary determined antimicrobial dosage before administration. Respondents used antimicrobials for therapeutic, prophylactic, and growth promotion in birds. Also, participants significantly identified contaminated poultry products, infected poultry or contaminated formites, and discharged contaminated faeces into environment as pathways for transmission of antimicrobial resistant pathogens to humans. Traffic Light system model revealed 88.5% of small-scale commercial poultry farms to frequently used antimicrobials without veterinarians' consultations thereby attaining Class 1 (Red risk) status. The model showed that 92.1% of free-range local bird flocks rarely used antimicrobials thereby attaining Class 3 (Green risk) status. Improper antimicrobial dosage in poultry (OR: 7.23; 95% CI: 2.74, 19.21), non-enforcement of AMU regulating laws in poultry (OR: 4.12; 95% CI: 2.39, 7.10), weak financial status of poultry owners (OR: 3.00; 95% CI: 2.39, 7.10), and management system (OR: 8.94; 95% CI: 5.62, 14.24) were more likely to satisfactorily influenced antimicrobials misuse in poultry farms and local bird flocks. The survey revealed low knowledge level regarding AMU in the poultry. Antimicrobials were rarely used in local bird flocks, making them likely organic and safe from AMR. It is imperative to educate farmers on judicious AMU, enforce existing veterinary legislation on antimicrobials, establish antimicrobials surveillance system, and sensitize farmers on adequate biosecurity measures and routine vaccination of farms, so as to assure food safety, food security, and public health. Copyright © 2018 Elsevier B.V. All rights reserved.

Nuclear Security Summit and Workshop 2015: Preventing, Understanding and Recovering from Nuclear Accidents lessons learned from Chernobyl and Fukushima

DTIC Science & Technology

2016-09-01

10 –3 cubic meter (m 3 ) cubic foot (ft 3 ) 2.831 685 × 10 –2 cubic meter (m 3 ) Mass /Density pound (lb) 4.535 924 × 10 –1 kilogram (kg...unified atomic mass unit (amu) 1.660 539 × 10 –27 kilogram (kg) pound- mass per cubic foot (lb ft –3 ) 1.601 846 × 10 1 kilogram per cubic meter (kg m...have a controlling infleunce on the solubility of actinides and fission products, and can be harnessed for non-invasive bioremediation. In the “far

User's guide to the Residual Gas Analyzer (RGA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Artman, S.A.

1988-08-04

The Residual Gas Analyzer (RGA), a Model 100C UTI quadrupole mass spectrometer, measures the concentrations of selected masses in the Fusion Energy Division's (FED) Advanced Toroidal Facility (ATF). The RGA software is a VAX FORTRAN computer program which controls the experimental apparatus, records the raw data, performs data reduction, and plots the data. The RGA program allows data to be collected from an RGA on ATF or from either of two RGAs in the laboratory. In the laboratory, the RGA diagnostic plays an important role in outgassing studied on various candidate materials for fusion experiments. One such material, graphite, ismore » being used more often in fusion experiments due to its ability to withstand high power loads. One of the functions of the RGA diagnostic is aid in the determination of the best grade of graphite to be used in these experiments and to study the procedures used to condition it. A procedure of particular interest involves baking the graphite sample in order to remove impurities that may be present in it. These impurities can be studied while in the ATF plasma or while being baked and outgassed in the laboratory. The Residual Gas Analyzer is a quadrupole mass spectrometer capable of scanning masses ranging in size from 1 atomic mass unit (amu) to 300 amu while under computer control. The procedure for collecting data for a particular mass is outlined.« less

Assessing Upper-Level Winds on Day-of-Launch

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Wheeler, Mark M.

2012-01-01

On the day-or-launch. the 45th Weather Squadron Launch Weather Officers (LWOS) monitor the upper-level winds for their launch customers to include NASA's Launch Services Program (LSP). During launch operations, the payload launch team sometimes asks the LWO if they expect the upper level winds to change during the countdown but the LWOs did not have the capability to quickly retrieve or display the upper-level observations and compare them to the numerical weather prediction model point forecasts. The LWOs requested the Applied Meteorology Unit (AMU) develop a capability in the form of a graphical user interface (GUI) that would allow them to plot upper-level wind speed and direction observations from the Kennedy Space Center Doppler Radar Wind Profilers and Cape Canaveral Air Force Station rawinsondes and then overlay model point forecast profiles on the observation profiles to assess the performance of these models and graphically display them to the launch team. The AMU developed an Excel-based capability for the LWOs to assess the model forecast upper-level winds and compare them to observations. They did so by creating a GUI in Excel that allows the LWOs to first initialize the models by comparing the O-hour model forecasts to the observations and then to display model forecasts in 3-hour intervals from the current time through 12 hours.

Lunar Hydrospheric Explorer (HYDROX)

NASA Technical Reports Server (NTRS)

Cooper, J. F.; Paschalidis, N.; Sittler, E. C., Jr.; Jones, S. L.; Stubbs, T. J.; Sarantos, M.; Khurana, K. K.; Angelopoulos, V.; Jordan, A. P.; Schwadron, N. A.

2015-01-01

The Lunar Hydrospheric Explorer (HYDROX) is a 6U CubeSat designed to further confirm the existence of lunar exospheric water, and to determine source processes and surface sites, through ion mass spectrometer measurements of water group (O+, OH+, H2O+) and related ions at energy charge up to 2 keV/e. and mass/charge 1-40amu/e. HYDROX would follow up on the now-concluded exospheric compositional measurements by the Neutral Mass Spectrometer on the NASA LADEE mission and on other remote sensing surface and exospheric measurements (LADEE,LRO, etc.).

Antimicrobial and SOD activities of novel transition metal ternary complexes of iminodiacetic acid containing alpha-diimine as auxiliary ligand.

PubMed

Siddiqi, Zafar A; Shahid, M; Khalid, Mohd; Kumar, S

2009-06-01

Ternary complexes containing an alpha-diimine auxiliary ligand have been widely used as models for several mono and polynuclear metal enzymes. The present ternary complexes [M(IDA)(Phen)H(2)O] x xH(2)O (x = 2, 3 or 4) were prepared as novel antimicrobial agents employing reactions of Cu(OAc)(2) or MCl(2) (M = Co, Ni, Cr) with iminodiacetic acid (H(2)IDA) in the presence of 1,10-phenanthroline (Phen), whose chemical structure and bonding were elucidated by IR, FAB-Mass, (1)H, (13)C NMR, EPR spectral and elemental analyses. The antimicrobial activities against Escherichia coli (K-12), Bacillus subtilis (MTCC 121), Staphylococcus aureus (IOA-SA-22), Salmonella typhimurium (MTCC 98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei (isolates from Department of Microbiology, Faculty of Agricultural Science, AMU) were investigated and significant activities were obtained. The superoxide dismutase activity of the Cu(II) complex was assessed by NBT assay. The single crystal X-ray structure for [Cu(IDA)(Phen)H(2)O] x 2 H(2)O indicates a triclinic unit cell in P-1 space group with structural parameters, a = 6.745(5), b = 10.551(5), c = 11.414(5)A, alpha = 95.770(5), beta = 91.396(5), gamma = 92.518(5) degrees and presence of an extensive H-bonding and pi-pi stacking interactions which generate a supramolecular framework.

High Time-Resolved Kinetic Temperatures of Solar Wind Minor Ions Measured with SOHO/CELIAS/CTOF

NASA Astrophysics Data System (ADS)

Janitzek, N. P.; Berger, L.; Drews, C.; Wimmer-Schweingruber, R. F.

2017-12-01

Solar wind heavy ions with an atomic number Z > 2 are referred to as minor ions since they represent a fraction of less than one percent of all solar wind ions. They can be therefore regarded as test particles, only reacting to but not driving the dynamics of the solar wind plasma, which makes them a unique diagnostic tool for plasma wave phenomena both in the solar atmosphere and the extended heliosphere. In the past, several studies have investigated the kinetic temperatures of minor ions, but due to low counting statistics these studies are based on ion velocity distribution functions (VDFs) recorded over time periods of several hours. The Charge Time-Of-Flight (CTOF) mass spectrometer as part of the Charge, ELement and Isotope Analysis System (CELIAS) onboard the SOlar and Heliospheric Observatory (SOHO) provides solar wind heavy ion 1D radial VDFs with excellent charge state separation, an unprecedented cadence of 5 minutes and very high counting statistics, exceeding similar state-of-the-art instruments by a factor of ten. In our study, based on CTOF measurements at Langrangian point L1 between DOY 150 and DOY 220 in 1996, we investigate systematically the influence of the VDF time resolution on the derived kinetic temperatures for solar wind silicon and iron ions. The selected ion set spans a wide range of mass-per-charge from 3 amu/e < m/q < 8 amu/e. Therefore, it is suitable for the search of signatures of gyrofrequency-dependent heating processes resulting from the resonant interaction of heavy ions with ion-cyclotron waves.

Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 β-Lactamase.

PubMed

Ruggiero, Melina; Papp-Wallace, Krisztina M; Taracila, Magdalena A; Mojica, Maria F; Bethel, Christopher R; Rudin, Susan D; Zeiser, Elise T; Gutkind, Gabriel; Bonomo, Robert A; Power, Pablo

2017-06-01

PER β-lactamases are an emerging family of extended-spectrum β-lactamases (ESBL) found in Gram-negative bacteria. PER β-lactamases are unique among class A enzymes as they possess an inverted omega (Ω) loop and extended B3 β-strand. These singular structural features are hypothesized to contribute to their hydrolytic profile against oxyimino-cephalosporins (e.g., cefotaxime and ceftazidime). Here, we tested the ability of avibactam (AVI), a novel non-β-lactam β-lactamase inhibitor to inactivate PER-2. Interestingly, the PER-2 inhibition constants (i.e., k 2 / K = 2 × 10 3 ± 0.1 × 10 3 M -1 s -1 , where k 2 is the rate constant for acylation (carbamylation) and K is the equilibrium constant) that were obtained when AVI was tested were reminiscent of values observed testing the inhibition by AVI of class C and D β-lactamases (i.e., k 2 / K range of ≈10 3 M -1 s -1 ) and not class A β-lactamases (i.e., k 2 / K range, 10 4 to 10 5 M -1 s -1 ). Once AVI was bound, a stable complex with PER-2 was observed via mass spectrometry (e.g., 31,389 ± 3 atomic mass units [amu] → 31,604 ± 3 amu for 24 h). Molecular modeling of PER-2 with AVI showed that the carbonyl of AVI was located in the oxyanion hole of the β-lactamase and that the sulfate of AVI formed interactions with the β-lactam carboxylate binding site of the PER-2 β-lactamase (R220 and T237). However, hydrophobic patches near the PER-2 active site (by Ser70 and B3-B4 β-strands) were observed and may affect the binding of necessary catalytic water molecules, thus slowing acylation ( k 2 / K ) of AVI onto PER-2. Similar electrostatics and hydrophobicity of the active site were also observed between OXA-48 and PER-2, while CTX-M-15 was more hydrophilic. To demonstrate the ability of AVI to overcome the enhanced cephalosporinase activity of PER-2 β-lactamase, we tested different β-lactam-AVI combinations. By lowering MICs to ≤2 mg/liter, the ceftaroline-AVI combination could represent a favorable therapeutic option against Enterobacteriaceae expressing bla PER-2 Our studies define the inactivation of the PER-2 ESBL by AVI and suggest that the biophysical properties of the active site contribute to determining the efficiency of inactivation. Copyright © 2017 American Society for Microbiology.

Exploring the Landscape of Diazabicyclooctane (DBO) Inhibition: Avibactam Inactivation of PER-2 β-Lactamase

PubMed Central

Ruggiero, Melina; Papp-Wallace, Krisztina M.; Taracila, Magdalena A.; Mojica, Maria F.; Bethel, Christopher R.; Rudin, Susan D.; Zeiser, Elise T.; Gutkind, Gabriel

2017-01-01

ABSTRACT PER β-lactamases are an emerging family of extended-spectrum β-lactamases (ESBL) found in Gram-negative bacteria. PER β-lactamases are unique among class A enzymes as they possess an inverted omega (Ω) loop and extended B3 β-strand. These singular structural features are hypothesized to contribute to their hydrolytic profile against oxyimino-cephalosporins (e.g., cefotaxime and ceftazidime). Here, we tested the ability of avibactam (AVI), a novel non-β-lactam β-lactamase inhibitor to inactivate PER-2. Interestingly, the PER-2 inhibition constants (i.e., k2/K = 2 × 103 ± 0.1 × 103 M−1 s−1, where k2 is the rate constant for acylation (carbamylation) and K is the equilibrium constant) that were obtained when AVI was tested were reminiscent of values observed testing the inhibition by AVI of class C and D β-lactamases (i.e., k2/K range of ≈103 M−1 s−1) and not class A β-lactamases (i.e., k2/K range, 104 to 105 M−1 s−1). Once AVI was bound, a stable complex with PER-2 was observed via mass spectrometry (e.g., 31,389 ± 3 atomic mass units [amu] → 31,604 ± 3 amu for 24 h). Molecular modeling of PER-2 with AVI showed that the carbonyl of AVI was located in the oxyanion hole of the β-lactamase and that the sulfate of AVI formed interactions with the β-lactam carboxylate binding site of the PER-2 β-lactamase (R220 and T237). However, hydrophobic patches near the PER-2 active site (by Ser70 and B3-B4 β-strands) were observed and may affect the binding of necessary catalytic water molecules, thus slowing acylation (k2/K) of AVI onto PER-2. Similar electrostatics and hydrophobicity of the active site were also observed between OXA-48 and PER-2, while CTX-M-15 was more hydrophilic. To demonstrate the ability of AVI to overcome the enhanced cephalosporinase activity of PER-2 β-lactamase, we tested different β-lactam–AVI combinations. By lowering MICs to ≤2 mg/liter, the ceftaroline-AVI combination could represent a favorable therapeutic option against Enterobacteriaceae expressing blaPER-2. Our studies define the inactivation of the PER-2 ESBL by AVI and suggest that the biophysical properties of the active site contribute to determining the efficiency of inactivation. PMID:28348157

First insights on the organic species from the high resolution mass spectrometer ROSINA DFMS on-board the Rosetta spacecraft

NASA Astrophysics Data System (ADS)

Le Roy, L.; Altwegg, K.; Berthelier, J. J.; Calmonte, U.; Dhooghe, F.; Fiethe, B.; Fuselier, S.; Gombosi, T. I.; Rubin, M.; Tzou, C. Y.

2014-12-01

Starting in August 2014, the ROSINA experiment will characterize the composition and dynamics of 67P/Churyumov-Gerasimenko's coma. ROSINA consists of a suite of three instruments: a pressure sensor (COPS: COmetary Pressure Sensor) and two mass spectrometers: the Reflectron Time of Flight mass spectrometer (RTOF) and the Double Focusing Mass Spectrometer (DFMS). Here we will focus on the first results obtained by DFMS, the high-resolution mass spectrometer of ROSINA. DFMS is a traditional magnetic mass spectrometer that combines an electrostatic analyzer for energy analysis with a magnet for momentum analysis. To date, DFMS is the highest mass resolution mass spectrometer in space, with resolution (m/Δm = 3000 at 1% of the peak height at 28 amu/q). It will be able to resolve CO from N2 at m/z= 28 amu/q or 12CH and 13C at m/z= 13 amu/q. We will present the first results of DFMS: the detection of organic species and their implication for the origin of cometary material.

Testing the Muon g-2 Anomaly at the LHC

DOE PAGES

Freitas, Ayres; Lykken, Joseph; Kell, Stefan; ...

2014-05-29

The long-standing difference between the experimental measurement and the standard-model prediction for the muon's anomalous magnetic moment,more » $$a_{\\mu} = (g_{\\mu}-2)/2$$, may be explained by the presence of new weakly interacting particles with masses of a few 100 GeV. Particles of this kind can generally be directly produced at the LHC, and thus they may already be constrained by existing data. In this work, we investigate this connection between $$a_{\\mu}$$ and the LHC in a model-independent approach, by introducing one or two new fields beyond the standard model with spin and weak isospin up to one. For each case, we identify the preferred parameter space for explaining the discrepancy of a_mu and derive bounds using data from LEP and the 8-TeV LHC run. Furthermore, we estimate how these limits could be improved with the 14-TeV LHC. We find that the 8-TeV results already rule out a subset of our simplified models, while almost all viable scenarios can be tested conclusively with 14-TeV data.« less

Formation of oligonucleotide adducts in pharmaceutical formulations.

PubMed

Krotz, Achim H; Gaus, Hans; Hardee, Gregory E

2005-01-01

During preformulation studies, we observed that oligonucleotide extracted from topical formulations contained considerable amounts of covalently modified oligonucleotide adducts. In this report, we describe the identification and characterization of reaction products that form when PS-oligodeoxyribonucleotide ISIS 2302 (1) is brought into contact with aqueous solutions of glycerol-derived excipients. Compatibility tests showed that the presence of certain glycerides in the formulation lead to adduct formation (1+58x amu, 1+72x amu, 1+58x+72y amu, x, and y are the number of modifications on one oligonucleotide strand). No adduct formation was observed in the presence of triglycerides or propylene glycol-derived excipients used in the study. Using nucleosides as model compounds, two modifications of deoxyguanosine were isolated by preparative reversed phase (RP)-high pressure liquid chromatography (HPLC) and characterized by nuclear magnetic resonance (NMR) and HPLC-mass spectrometry (MS). Modifications were identified as N2-(1-carboxymethyl)- and N2-(1-carboxyethyl) derivatives of 2'-deoxyguanosine. The mechanism of formation of these adducts may involve advanced glycation reactions possibly caused by excipient impurities or degradation products such as glyceraldehyde or glyceraldehyde derivatives.

A balloon measurement of the isotopic composition of galactic cosmic ray boron, carbon and nitrogen. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Zumberge, J. F.

1981-01-01

The isotopic compositions of galactic cosmic ray boron, carbon, and nitrogen were measured at energies near 300 MeV amu, using a balloon-borne instrument at an atmospheric depth of approximately 5 g/sq cm. The calibrations of the detectors comprising the instrument are described. The saturation properties of the cesium iodide scintillators used for measurement of particle energy are studied in the context of analyzing the data for mass. The achieved rms mass resolution varies from approximately 0.3 amu at boron to approximately 0.5 amu at nitrogen, consistent with a theoretical analysis of the contributing factors. Corrected for detector interactions and the effects of the residual atmosphere the results are B-10/B=0.33 (+0.17, -0.11), C-13/C=0.06 (+0.13, -0.11), and N-15/N=0.42 (+0.19, -0.17). A model of galactic propagation and solar modulation is described. Assuming a cosmic ray source composition of solar-like isotopic abundances, the model predicts abundances near Earth consistent with the measurements.

Measurements and calculations of the Coulomb cross section for the production of direct electron pairs by energetic heavy nuclei in nuclear track emulsion

NASA Technical Reports Server (NTRS)

Derrickson, J. H.; Eby, P. B.; Fountain, W. F.; Parnell, T. A.; Dong, B. L.; Gregory, J. C.; Takahashi, Y.; King, D. T.

1988-01-01

Measurements and theoretical predictions of the Coulomb cross section for the production of direct electron pairs by heavy ions in emulsion have been performed. Nuclear track emulsions were exposed to the 1.8 GeV/amu Fe-56 beam at the Lawrence Berkeley Laboratory bevalac and to the 60 and 200 GeV/amu O-16 and the 200 GeV/amu S-32 beam at the European Center for Nuclear Research Super Proton Synchrotron modified to accelerate heavy ions. The calculations combine the Weizsacker-Williams virtual quanta method applicable to the low-energy transfers and the Kelner-Kotov relativistic treatment for the high-energy transfers. Comparison of the measured total electron pair yield, the energy transfer distribution, and the emission angle distribution with theoretical predictions revealed a discrepancy in the frequency of occurrence of the low-energy pairs (less than or = 10 MeV). The microscope scanning criteria used to identify the direct electron pairs is described and efforts to improve the calculation of the cross section for pair production are also discussed.

Abundances and energy spectra of high energy heavy cosmic-ray nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barthelmy, S.D.

1985-01-01

We have measured the relative abundances of the cosmic rays in the iron group region at energies from a few GeV/amu to approximately 70 GeV/amu. This is done using a balloon-borne instrument consisting of gas ionization chambers, a plastic scintillator, a plastic Cherenkov counter, and a CO/sub 2/ gas Cherenkov counter. The instrument was flown from Palestine, Texas in the fall of 1982 for a total exposure of 62 m/sup 2/-ster-hr at an average atmospheric depth of 4 g/cm/sup 2/. The elemental charge was determined for a combination of the scintillator and plastic Cherenkov detector. Results are reported on themore » /sub 22/Ti//sub 26/Fe, /sub 24/Cr//sub 26/Fe, /sub 20/Ca//sub 26/Fe, and /sub 28/Ni//sub 28/Fe abundance ratios from 2 to 70 GeV/amu. Within this work results on the previously unused method of relativistic rise in gas ionization chambers is detailed as well as results on the return to nonsaturation of plastic scintillators.« less

Relative abundances of elements (20 or = Z or = 28) at energies up to 70 GeV/amu using relativistic rise in ion chambers

NASA Technical Reports Server (NTRS)

Barthelmy, S. D.; Israel, M. H.; Klarmann, J.

1985-01-01

The results of a new balloon borne cosmic ray detector flown from Palestine, TX in Sept., 1982 are discussed. The exposure of 62 square meter-ster-hr is sufficient to prove the concept of using gas ionization chambers as energy measuring devices in the relativistic rise region. The abundances, relative Fe-26, of the pure secondaries Cr-22 and Ti-24, the pure primary Ni26, and the mixed primary and secondary Ca-20 between 6 and 70GeV/amu were measured.

Antimicrobial resistance and small ruminant veterinary practice.

PubMed

Scott, Lisa C; Menzies, Paula I

2011-03-01

Antimicrobial resistance (AMR) is recognized as an emerging issue in the practice of veterinary medicine. Although little surveillance and research has been completed on the prevalence of AMR and associated risk factors in small ruminants, evidence of AMR is present in many countries. Furthermore, antimicrobial use (AMU) practices in sheep have been shown to be associated with increased resistance, highlighting the issue of prudent use of these drugs in many countries. Furthermore, AMU practices in sheep have been shown to be associated with increased resistance, highlighting the issue of prudent use of these drugs. Copyright © 2011 Elsevier Inc. All rights reserved.

Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe

NASA Technical Reports Server (NTRS)

Costes, S.; Barcellos-Hoff, M. H.

2002-01-01

This paper summarizes quantitative in vivo laminin immunofluorescence analysis of mammary glands and skin epithelial structures from mice exposed to 1 GeV/amu Fe ions. Digital confocal microscopic images were quantified and linked to the rough "core-penumbra" Fe track physical description. Comparison to gamma-ray sparsely ionizing radiation suggested the core of the Fe track being responsible for a biological response only seen with energetic Fe particles. Conclusions for modeling in vivo responses to radiation were then implied. c2002 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

The Scintillating Optical Fiber Calorimeter Instrument Performance (SOFCAL)

NASA Technical Reports Server (NTRS)

Christl, M. J.; Benson, C. M.; Berry, F. A.; Fountain, W. F.; Gregory, J. C.; Johnson, J. S.; Munroe, R. B.; Parnell, T. A.; Takahashi, Y.; Watts, J. W.

1999-01-01

SOFCAL is a balloon-borne instrument designed to measure the P-He cosmic ray spectra from about 200 GeV/amu - 20 TeV/amu. SOFCAL uses a thin lead and scintillating-fiber ionization calorimeter to measure the cascades produced by cosmic rays interacting in the hybrid detector system. Above the fiber calorimeter is an emulsion chamber that provides the interaction target, primary particle identification and in-flight energy calibration for the scintillating fiber data. The energy measurement technique and its calibration are described, and the present results from the analysis of a 1 day balloon flight will be presented.

Cosmic-ray isotopic composition of C, N, O, Ne, Mg, Si nuclei in the energy range 50-200 MeV per nucleon measured by the Voyager spacecraft during the solar minimum period

NASA Technical Reports Server (NTRS)

Lukasiak, A.; Ferrando, P.; Mcdonald, F. B.; Webber, W. R.

1994-01-01

The isotopic composition of C, N, O, Ne, Mg, Si cosmic ray nuclei has been measured in the energy range 50-200 MeV per nucleon using data collected by the High-Energy Telescope of the cosmic-ray subsystem experiment on the Voyager 1 and 2 spacecraft. These data were collected during the period of minimum solar activity in 1986-1988 at an average distance of 27 AU with an effective solar modulation that was much less than at the Earth. The isotope analysis, based on the energy loss - total energy method, has a mass resolution of 0.2 amu for carbon and 0.4 amu at silicon. We find a (C-13)/(C-12) ratio slightly lower and a (O-18)/(O-16) ratio slightly enhanced over their solar system value. We also observe the previously reported enhancement of the (Ne-22)/(Ne-20) ratio relative to solar at the cosmic-ray source but only a weak, if any, enhancement of the (Mg-25)/(Mg-24), (Mg-26)/(Mg 24), and (Si-30)/(Si-28) ratios.

The influence of dose, dose-rate and particle fragmentation on cataract induction by energetic iron ions

NASA Technical Reports Server (NTRS)

Medvedovsky, C.; Worgul, B. V.; Huang, Y.; Brenner, D. J.; Tao, F.; Miller, J.; Zeitlin, C.; Ainsworth, E. J.

1994-01-01

Because activities in space necessarily involve chronic exposure to a heterogeneous charged particle radiation field it is important to assess the influence of dose-rate and the possible modulating role of heavy particle fragmentation on biological systems. Using the well-studied cataract model, mice were exposed to plateau 600 MeV/amu Fe-56 ions either as acute or fractionated exposures at total doses of 5-504 cGy. Additional groups of mice received 20, 360 and 504 cGy behind 50 mm of polyethylene, which simulates body shielding. The reference radiation consisted of Co-60 gamma radiation. The animals were examined by slit lamp biomicroscopy over their three year life spans. In accordance with our previous observations with heavy particles, the cataractogenic potential of the 600 MeV/amu Fe-56 ions was greater than for low-Linear Energy Transfer (LET) radiation and increased with decreasing dose relative to gamma rays. Fractionation of a given dose of Fe-56 ions did not reduce the cataractogenicity of the radiation compared to the acute regimen. Fragmentation of the beam in the polyethylene did not alter the cataractotoxicity of the ions, either when administered singly or in fractions.

The influence of dose, dose-rate and particle fragmentation on cataract induction by energetic iron ions

NASA Astrophysics Data System (ADS)

Medvedovsky, C.; Worgul, B. V.; Huang, Y.; Brenner, D. J.; Tao, F.; Miller, J.; Zeitlin, C.; Ainsworth, E. J.

1994-10-01

Because activities in space necessarily involve chronic exposure to a heterogeneous charged particle radiation field it is important to assess the influence of dose-rate and the possible modulating role of heavy particle fragmentation on biological systems. Using the well-studied cataract model, mice were exposed to plateau 600 MeV/amu 56Fe ions either as acute or fractionated exposures at total doses of 5 - 504 cGy. Additional groups of mice received 20, 360 and 504 cGy behind 50 mm of polyethylene, which simulates body shielding. The reference radiation consisted of 60Co γ radiation. The animals were examined by slit lamp biomicroscopy over their three year life spans. In accordance with our previous observations with heavy particles, the cataractogenic potential of the 600 MeV/amu 56Fe ions was greater than for low-LET radiation and increased with decreasing dose relative to γ-rays. Fractionation of a given dose of 56Fe ions did not reduce the cataractogenicity of the radiation compared to the acute regimen. Fragmentation of the beam in the polyethylene did not alter the cataractotoxicity of the ions, either when administered singly or in fractions.

A novel double-focusing time-of-flight mass spectrometer for absolute recoil ion cross sections measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sigaud, L., E-mail: lsigaud@if.uff.br; Jesus, V. L. B. de; Ferreira, Natalia

In this work, the inclusion of an Einzel-like lens inside the time-of-flight drift tube of a standard mass spectrometer coupled to a gas cell—to study ionization of atoms and molecules by electron impact—is described. Both this lens and a conical collimator are responsible for further focalization of the ions and charged molecular fragments inside the spectrometer, allowing a much better resolution at the time-of-flight spectra, leading to a separation of a single mass-to-charge unit up to 100 a.m.u. The procedure to obtain the overall absolute efficiency of the spectrometer and micro-channel plate detector is also discussed.

A novel double-focusing time-of-flight mass spectrometer for absolute recoil ion cross sections measurements.

PubMed

Sigaud, L; de Jesus, V L B; Ferreira, Natalia; Montenegro, E C

2016-08-01

In this work, the inclusion of an Einzel-like lens inside the time-of-flight drift tube of a standard mass spectrometer coupled to a gas cell-to study ionization of atoms and molecules by electron impact-is described. Both this lens and a conical collimator are responsible for further focalization of the ions and charged molecular fragments inside the spectrometer, allowing a much better resolution at the time-of-flight spectra, leading to a separation of a single mass-to-charge unit up to 100 a.m.u. The procedure to obtain the overall absolute efficiency of the spectrometer and micro-channel plate detector is also discussed.

Birthplace choices: what are the information needs of women when choosing where to give birth in England? A qualitative study using online and face to face focus groups.

PubMed

Hinton, Lisa; Dumelow, Carol; Rowe, Rachel; Hollowell, Jennifer

2018-01-08

Current clinical guidelines and national policy in England support offering 'low risk' women a choice of birth setting. Options include: home, free-standing midwifery unit (FMU), alongside midwifery unit (AMU) or obstetric unit (OU). This study, which is part of a broader project designed to inform policy on 'choice' in relation to childbirth, aimed to provide evidence on UK women's experiences of choice and decision-making in the period since the publication of the Birthplace findings (2011) and new NICE guidelines (2014). This paper reports on findings relating to women's information needs when making decisions about where to give birth. A qualitative focus group study including 69 women in the last trimester of pregnancy in England in 2015-16. Seven focus groups were conducted online via a bespoke web portal, and one was face-to-face. To explore different aspects of women's experience, each group included women with specific characteristics or options; planning a home birth, living in areas with lots of choice, living in areas with limited choice, first time mothers, living close to a FMU, living in opt-out AMU areas, living in socioeconomically disadvantaged areas and planning to give birth in an OU. Focus group transcripts were analysed thematically. Women drew on multiple sources when making choices about where to give birth. Sources included; the Internet, friends' recommendations and experiences, antenatal classes and their own personal experiences. Their midwife was not the main source of information. Women wanted the option to discuss and consider their birth preferences throughout their pregnancy, not at a fixed point. Birthplace choice is informed by many factors. Women may encounter fewer overt obstacles to exercising choice than in the past, but women do not consistently receive information about birthplace options from their midwife at a time and in a manner that they find helpful. Introducing options early in pregnancy, but deferring decision-making about birthplace until a woman has had time to consider and explore options and discuss these with her midwife, might facilitate choice.

Evolution of the coma composition at 67P/Churyumov-Gerasimenko as seen by ROSINA/Rosetta from November 2014 to April 2015

NASA Astrophysics Data System (ADS)

Gasc, Sébastien; Altwegg, Kathrin; Balsiger, Hans; Calmonte, Ursina; Galli, André; Jäckel, Annette; Le Roy, Léna; Rubin, Martin; Tzou, Chia-Yu; Wurz, Peter; Berthelier, Jean-Jacques; Fiethe, Björn; Fuselier, Stephen; Gombosi, Tamas; De Keyser, Johan; Mall, Urs; Rème, Henri

2015-04-01

The European Space Agency's Rosetta spacecraft, with the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) onboard [1], has been following and observing comet 67P/Churyumov-Gerasimenko (67P/C-G) since August 2014. ROSINA has provided new information on the molecular, elemental, and isotopic composition of 67P/C-G's coma [2,3]. ROSINA consists of a pressure sensor (COPS) and two mass spectrometers, the Double Focusing Mass Spectrometer (DFMS) and the Reflectron Time Of Flight mass spectrometer (RTOF). DFMS has a high mass resolution (ca. 3'000 at 1%) and a high sensitivity, whereas RTOF has a wide mass range (from 1 amu/e to >300 amu/e) and a high temporal resolution. Both mass spectrometers are designed to measure cometary neutral gas as well as cometary ions. In this work, we present the first results and discuss the evolution of the composition of the coma measured by ROSINA from November 2014 until the end of March 2015. During this period, Rosetta delivered the lander, then stayed in bound orbits at distances of 20-30 km away from the comet center, and finally performed comet flybys from 10 km up to 250 km away from 67P/C-G. [1] Balsiger, H. et al.: ROSINA-Rosetta Orbiter Spectrometer for Ion and Neutral Analysis, Space Science Reviews, Vol. 128, 745-801, 2007 [2] Altwegg, K. et al.: Comet 67P/Churyumov-Gerasimenko, a true Kuiper belt comet as judged from its D/H in water, Science Express, 2014 [3] Hässig, M. et al.: Time variability and heterogeneity in the coma of 67P/Churyumov-Gerasimenko, Science, in press, 2015

Analysis of Rapidly Developing Low Cloud Ceilings in a Stable Environment

NASA Technical Reports Server (NTRS)

Wheeler, Mark M.; Case, Jonathan L.

2005-01-01

This report describes the work done by the Applied Meteorology Unit (AMU) in developing a database of days that experienced rapid (< 90 minutes) low cloud formation in a stable atmosphere, resulting in ceilings at the Shuttle Landing Facility (TTS) that violated Space Shuttle Flight Rules (FR). The meteorological conditions favoring the rapid formation of low ceilings include the presence of any inversion below 8000 ft, high relative humidity beneath the inversion, and a clockwise turning of the winds from the surface to the middle troposphere (approx. 15000 ft). The AMU compared and contrasted the atmospheric and thermodynamic conditions between days with rapid low ceiling formation and days with low ceiling resulting from other mechanism. The AMU found that the vertical wind profile is the probable discerning factor between the rapidly-forming ceiling days and other low ceiling days at TTS. Most rapidly-developing low ceiling days had a clockwise turning of the winds with height, whereas other low ceiling days typically had a counter-clockwise turning of the winds with height or negligible vertical wind shear. Forecasters at the Space Meteorology Group (SMG) issue 30 to 90 minute forecasts for low cloud ceilings at TTS to support Space Shuttle landings. Mission verification statistics have shown ceilings to be the number one forecast challenge. More specifically, forecasters at SMG are concerned with any rapidly developing clouds ceilings below 8000 ft in a stable, capped thermodynamic environment, Therefore, the AMU was tasked to examine archived events of rapid stable cloud formation resulting in ceilings below 8000 ft, and document the atmospheric regimes favoring this type of cloud development. The AMU examined the cool season months of November to March during the years of 1993-2003 for days that had low-level inversions and rapid, stable low cloud formation that resulted in ceilings violating the Space Shuttle FR. The AMU wrote and modified existing code to identify inversions from the morning Cape Canaveral, FL rawinsonde (XMR) during the cool season and output pertinent sounding information. They parsed all days with cloud ceilings below 8000 ft at TTS, forming a database of possible rapidly-developing low ceiling events. Days with precipitation or noticeable fog bum-off situations were excluded from the database. Only the daytime hours were examined for possible ceiling development events since low clouds are easier to diagnose with visible satellite imagery. Follow-on work would expand the database to include nighttime cases, using a special enhancement of the infrared imagery for identifying areas of low clouds. The report presents two sample cases of rapidly-developing low cloud ceilings. These cases depict the representative meteorological and thermodynamic characteristics of such events. The cases also illustrate how quickly the cloud decks can develop, sometimes forming in 30 minutes or less. The report also summarizes the composite meteorological conditions for 20 event days with rapid low cloud ceiling formation and 48 non-events days consisting of advection or widespread low cloud ceilings. The meteorological conditions were quite similar for both the event and non-event days, since both types of days experienced low cloud ceilings. Both types of days had a relatively moist environment beneath the inversion based below 8000 ft. In the 20 events identified, de onset of low ceilings occurred between 1200-1800 UTC in every instance. The distinguishing factor between the event and non-event days appears to be the vertical wind profile in the XMR sounding. Eighty-five percent of the event days had a clockwise turning of the winds with height in the lower to middle troposphere whereas 83% of the non-events had a counter-clockwise turning of the winds with height or negligible vertical wind shear. A clockwise turning of the winds with height indicates a warm advection regime, which supports large-scale rising motn and possible cloud formation. Meanwhile, a counter-clockwise turning of the winds with height indicates cold advection or sinking motion in a post-cold frontal environment.

Integrating Wind Profiling Radars and Radiosonde Observations with Model Point Data to Develop a Decision Support Tool to Assess Upper-Level Winds for Space Launch

NASA Technical Reports Server (NTRS)

Bauman, William H., III; Flinn, Clay

2013-01-01

On the day of launch, the 45th Weather Squadron (45 WS) Launch Weather Officers (LWOs) monitor the upper-level winds for their launch customers. During launch operations, the payload/launch team sometimes asks the LWOs if they expect the upper-level winds to change during the countdown. The LWOs used numerical weather prediction model point forecasts to provide the information, but did not have the capability to quickly retrieve or adequately display the upper-level observations and compare them directly in the same display to the model point forecasts to help them determine which model performed the best. The LWOs requested the Applied Meteorology Unit (AMU) develop a graphical user interface (GUI) that will plot upper-level wind speed and direction observations from the Cape Canaveral Air Force Station (CCAFS) Automated Meteorological Profiling System (AMPS) rawinsondes with point forecast wind profiles from the National Centers for Environmental Prediction (NCEP) North American Mesoscale (NAM), Rapid Refresh (RAP) and Global Forecast System (GFS) models to assess the performance of these models. The AMU suggested adding observations from the NASA 50 MHz wind profiler and one of the US Air Force 915 MHz wind profilers, both located near the Kennedy Space Center (KSC) Shuttle Landing Facility, to supplement the AMPS observations with more frequent upper-level profiles. Figure 1 shows a map of KSC/CCAFS with the locations of the observation sites and the model point forecasts.

Toward a Micro Gas Chromatograph/Mass Spectrometer (GC/MS) System

NASA Technical Reports Server (NTRS)

Wiberg, D. V.; Eyre, F. B.; Orient, O.; Chutjian, A.; Garkarian, V.

2001-01-01

Miniature mass filters (e.g., quadrupoles, ion traps) have been the subject of several miniaturization efforts. A project is currently in progress at JPL to develop a miniaturized Gas Chromatograph/Mass Spectrometer (GC/MS) system, incorporating and/or developing miniature system components including turbomolecular pumps, scroll type roughing pump, quadrupole mass filter, gas chromatograph, precision power supply and other electronic components. The preponderance of the system elements will be fabricated using microelectromechanical systems (MEMS) techniques. The quadrupole mass filter will be fabricated using an X-ray lithography technique producing high precision, 5x5 arrays of quadrupoles with pole lengths of about 3 mm and a total volume of 27 cubic mm. The miniature scroll pump will also be fabricated using X-ray lithography producing arrays of scroll stages about 3 mm in diameter. The target detection range for the mass spectrometer is 1 to 300 atomic mass units (AMU) with are solution of 0.5 AMU. This resolution will allow isotopic characterization for geochronology, atmospheric studies and other science efforts dependant on the understanding of isotope ratios of chemical species. This paper will discuss the design approach, the current state-of-the art regarding the system components and the progress toward development of key elements. The full system is anticipated to be small enough in mass, volume and power consumption to allow in situ chemical analysis on highly miniaturized science craft for geochronology, atmospheric characterization and detection of life experiments applicable to outer planet roadmap missions.

Mass separation of deuterium and helium with conventional quadrupole mass spectrometer by using varied ionization energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Yaowei; Hu, Jiansheng, E-mail: hujs@ipp.ac.cn; Wan, Zhao

2016-03-15

Deuterium pressure in deuterium-helium mixture gas is successfully measured by a common quadrupole mass spectrometer (model: RGA200) with a resolution of ∼0.5 atomic mass unit (AMU), by using varied ionization energy together with new developed software and dedicated calibration for RGA200. The new software is developed by using MATLAB with the new functions: electron energy (EE) scanning, deuterium partial pressure measurement, and automatic data saving. RGA200 with new software is calibrated in pure deuterium and pure helium 1.0 × 10{sup −6}–5.0 × 10{sup −2} Pa, and the relation between pressure and ion current of AMU4 under EE = 25 eVmore » and EE = 70 eV is obtained. From the calibration result and RGA200 scanning with varied ionization energy in deuterium and helium mixture gas, both deuterium partial pressures (P{sub D{sub 2}}) and helium partial pressure (P{sub He}) could be obtained. The result shows that deuterium partial pressure could be measured if P{sub D{sub 2}} > 10{sup −6} Pa (limited by ultimate pressure of calibration vessel), and helium pressure could be measured only if P{sub He}/P{sub D{sub 2}} > 0.45, and the measurement error is evaluated as 15%. This method is successfully employed in EAST 2015 summer campaign to monitor deuterium outgassing/desorption during helium discharge cleaning.« less

Modeling of the phase equilibria of polystyrene in methylcyclohexane with semi-empirical quantum mechanical methods I.

PubMed

Wilczura-Wachnik, Hanna; Jónsdóttir, Svava Osk

2003-04-01

A method for calculating interaction parameters traditionally used in phase-equilibrium computations in low-molecular systems has been extended for the prediction of solvent activities of aromatic polymer solutions (polystyrene+methylcyclohexane). Using ethylbenzene as a model compound for the repeating unit of the polymer, the intermolecular interaction energies between the solvent molecule and the polymer were simulated. The semiempirical quantum chemical method AM1, and a method for sampling relevant internal orientations for a pair of molecules developed previously were used. Interaction energies are determined for three molecular pairs, the solvent and the model molecule, two solvent molecules and two model molecules, and used to calculated UNIQUAC interaction parameters, a(ij) and a(ji). Using these parameters, the solvent activities of the polystyrene 90,000 amu+methylcyclohexane system, and the total vapor pressures of the methylcyclohexane+ethylbenzene system were calculated. The latter system was compared to experimental data, giving qualitative agreement. Figure Solvent activities for the methylcylcohexane(1)+polystyrene(2) system at 316 K. Parameters aij (blue line) obtained with the AM1 method; parameters aij (pink line) from VLE data for the ethylbenzene+methylcyclohexane system. The abscissa is the polymer weight fraction defined as y2(x1)=(1mx1)M2/[x1M1+(1mx1)M2], where x1 is the solvent mole fraction and Mi are the molecular weights of the components.

Calcium isotopic anomalies and the lack of aluminum-26 in an unusual Allende inclusion

NASA Technical Reports Server (NTRS)

Lee, T.; Russell, W. A.; Wasserburg, G. J.

1979-01-01

This letter reports the discovery of an unusual Allende inclusion that is rich in hibonite, Ca(Al, Ti, Mg)12O19, the most refractory and possibly the most primitive major oxide mineral from the solar nebula. The Mg and Ca isotopic compositions of this hibonite-rich inclusion are studied in order to investigate the distribution of Al-26 in the solar system and to extend the search for isotopic anomalies. The Mg results indicate that no Mg isotopic anomalies are present, that the initial Al-26/Al-27 ratio for the inclusion when it crystallized was less than 200 billionths, and that the Mg mass-fractionation effect in the inclusion must be less than about 20 per mil/amu for the hibonite and 10 per mil/amu for other phases. The Ca studies reveal that large Ca mass-fractionation effects of about 7.5 per mil/amu are present and that additional small 'nonlinear' effects of presumably nuclear origin at a level of about 1 to 2 per mil are present in at least Ca-42. A plausible model for the evolution of the hibonite-rich inclusion is outlined.

Peak Wind Tool for General Forecasting

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III

2010-01-01

The expected peak wind speed of the day is an important forecast element in the 45th Weather Squadron's (45 WS) daily 24-Hour and Weekly Planning Forecasts. The forecasts are used for ground and space launch operations at the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). The 45 WS also issues wind advisories for KSC/CCAFS when they expect wind gusts to meet or exceed 25 kt, 35 kt and 50 kt thresholds at any level from the surface to 300 ft. The 45 WS forecasters have indicated peak wind speeds are challenging to forecast, particularly in the cool season months of October - April. In Phase I of this task, the Applied Meteorology Unit (AMU) developed a tool to help the 45 WS forecast non-convective winds at KSC/CCAFS for the 24-hour period of 0800 to 0800 local time. The tool was delivered as a Microsoft Excel graphical user interface (GUI). The GUI displayed the forecast of peak wind speed, 5-minute average wind speed at the time of the peak wind, timing of the peak wind and probability the peak speed would meet or exceed 25 kt, 35 kt and 50 kt. For the current task (Phase II ), the 45 WS requested additional observations be used for the creation of the forecast equations by expanding the period of record (POR). Additional parameters were evaluated as predictors, including wind speeds between 500 ft and 3000 ft, static stability classification, Bulk Richardson Number, mixing depth, vertical wind shear, temperature inversion strength and depth and wind direction. Using a verification data set, the AMU compared the performance of the Phase I and II prediction methods. Just as in Phase I, the tool was delivered as a Microsoft Excel GUI. The 45 WS requested the tool also be available in the Meteorological Interactive Data Display System (MIDDS). The AMU first expanded the POR by two years by adding tower observations, surface observations and CCAFS (XMR) soundings for the cool season months of March 2007 to April 2009. The POR was expanded again by six years, from October 1996 to April 2002, by interpolating 1000-ft sounding data to 100-ft increments. The Phase II developmental data set included observations for the cool season months of October 1996 to February 2007. The AMU calculated 68 candidate predictors from the XMR soundings, to include 19 stability parameters, 48 wind speed parameters and one wind shear parameter. Each day in the data set was stratified by synoptic weather pattern, low-level wind direction, precipitation and Richardson Number, for a total of 60 stratification methods. Linear regression equations, using the 68 predictors and 60 stratification methods, were created for the tool's three forecast parameters: the highest peak wind speed of the day (PWSD), 5-minute average speed at the same time (A WSD), and timing of the PWSD. For PWSD and A WSD, 30 Phase II methods were selected for evaluation in the verification data set. For timing of the PWSD, 12 Phase\\I methods were selected for evaluation. The verification data set contained observations for the cool season months of March 2007 to April 2009. The data set was used to compare the Phase I and II forecast methods to climatology, model forecast winds and wind advisories issued by the 45 WS. The model forecast winds were derived from the 0000 and 1200 UTC runs of the 12-km North American Mesoscale (MesoNAM) model. The forecast methods that performed the best in the verification data set were selected for the Phase II version of the tool. For PWSD and A WSD, linear regression equations based on MesoNAM forecasts performed significantly better than the Phase I and II methods. For timing of the PWSD, none of the methods performed significantly bener than climatology. The AMU then developed the Microsoft Excel and MIDDS GUls. The GUIs display the forecasts for PWSD, AWSD and the probability the PWSD will meet or exceed 25 kt, 35 kt and 50 kt. Since none of the prediction methods for timing of the PWSD performed significantly better thanlimatology, the tool no longer displays this predictand. The Excel and MIDDS GUIs display forecasts for Day-I to Day-3 and Day-I to Day-5, respectively. The Excel GUI uses MesoNAM forecasts as input, while the MIDDS GUI uses input from the MesoNAM and Global Forecast System model. Based on feedback from the 45 WS, the AMU added the daily average wind speed from 30 ft to 60 ft to the tool, which is one of the parameters in the 24-Hour and Weekly Planning Forecasts issued by the 45 WS. In addition, the AMU expanded the MIDDS GUI to include forecasts out to Day-7.

Antimicrobial use on Canadian dairy farms.

PubMed

Saini, V; McClure, J T; Léger, D; Dufour, S; Sheldon, A G; Scholl, D T; Barkema, H W

2012-03-01

Antimicrobial use (AMU) data are critical for formulating policies for containing antimicrobial resistance. The present study determined AMU on Canadian dairy farms and characterized variation in AMU based on herd-level factors such as milk production, somatic cell count, herd size, geographic region and housing type. Drug use data were collected on 89 dairy herds in 4 regions of Canada, Alberta, Ontario, Québec, and the Maritime provinces (Prince Edward Island, New Brunswick, and Nova Scotia) for an average of 540 d per herd. Dairy producers and farm personnel were asked to deposit empty drug containers into specially provided receptacles. Antimicrobial use was measured as antimicrobial drug use rate (ADUR), with the unit being number of animal defined-daily doses (ADD)/1,000 cow-days. Antimicrobial drug use rates were determined at farm, region, and national level. Combined ADUR of all antimicrobial classes was 14.35 ADD/1,000 cow-days nationally. National level ADUR of the 6 most commonly used antimicrobial drug classes, cephalosporins, penicillins, penicillin combinations, tetracyclines, trimethoprim-sulfonamide combinations, and lincosamides were 3.05, 2.56, 2.20, 1.83, 0.87, and 0.84 ADD/1,000 cow-days, respectively. Dairy herds in Ontario were higher users of third-generation cephalosporins (ceftiofur) than in Québec. Alberta dairy herds were higher users of tetracyclines in comparison to Maritimes. Antimicrobial drug use rate was higher via systemic route as compared with intramammary and other routes of administration (topical, oral, and intrauterine). The ADUR of antimicrobials used intramammarily was higher for clinical mastitis treatment than dry cow therapy. For dry cow therapy, penicillin ADUR was greater than ADUR of first-generation cephalosporins. For clinical mastitis treatment, ADUR of intramammary penicillin combinations was greater than ADUR of cephapirin. Herd-level milk production was positively associated with overall ADUR, ADUR of systemically administered ceftiofur, cephapirin administered for dry cow therapy, and pirlimycin administered for clinical mastitis treatment. Herd size and ADUR of systemically administered ceftiofur were also positively associated. In conclusion, β-lactams were most commonly used on Canadian dairy farms. Among antimicrobials of very high importance in human medicine, the use of fluoroquinolones was rare, whereas third-generation cephalosporins and penicillin combinations containing colistin were used very frequently on Canadian dairy farms. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

A Systems Analysis View of the Vietnam War 1965-1972. Volume 9. Population Security

DTIC Science & Technology

1975-02-01

CONPIDENTAL- DAA JJ* t I fe’. 18 CONFIDIBNITPALu3 C *’• SOUTH VIETNAM AMU STATUS VC cONUOU HAMMET I (I :I *, . ,A S~CONIDENTIAL GVN WRAL POMUITI0N CONTROL...ce they were not A-B hamlets at the beginning or end of the year. TABLE 2 A-B HAN BALMZ SHEET F(IC0R IWL RAWD HAMMET Pattern Types No. Population...is statistically insignificant in this equation . High kill ratios are associated with periods of high VC/NVA activity, so this model is consistent

High current H{sub 2}{sup +} cyclotrons for neutrino physics: The IsoDAR and DAE{delta}ALUS projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alonso, Jose R.; Collaboration: DAE delta ALUS Collaboration

2013-04-19

Using H{sub 2}{sup +} ions is expected to mitigate the two major impediments to accelerating very high currents in cyclotrons, due to lower space charge at injection, and stripping extraction. Planning for peak currents of 10 particle milliamps at 800 MeV/amu, these cyclotrons can generate adequate neutrino fluxes for Decay-At-Rest (DAR) studies of neutrino oscillation and CP violation. The Injector Cyclotron, at 60 MeV/amu can also provide adequate fluxes of electron antineutrinos from {sup 8}Li decay for sterile neutrino searches in existing liquid scintillator detectors at Kam LAND or SNO+. This paper outlines programs for designing and building these machines.

Investigation of cloud condensation nuclei properties and droplet growth kinetics of the water-soluble aerosol fraction in Mexico City

NASA Astrophysics Data System (ADS)

Padró, Luz T.; Tkacik, Daniel; Lathem, Terry; Hennigan, Chris J.; Sullivan, Amy P.; Weber, Rodney J.; Huey, L. Greg; Nenes, Athanasios

2010-05-01

We present hygroscopic and cloud condensation nuclei (CCN) relevant properties of the water-soluble fraction of Mexico City aerosol collected upon filters during the 2006 Megacity Initiative: Local and Global Research Observations (MILAGRO) campaign. Application of κ-Köhler theory to the observed CCN activity gave a fairly constant hygroscopicity parameter (κ = 0.28 ± 0.06) regardless of location and organic fraction. Köhler theory analysis was used to understand this invariance by separating the molar volume and surfactant contributions to the CCN activity. Organics were found to depress surface tension (10-15%) from that of pure water. Daytime samples exhibited lower molar mass (˜200 amu) and surface tension depression than nighttime samples (˜400 amu); this is consistent with fresh hygroscopic secondary organic aerosol (SOA) condensing onto particles during peak photochemical hours, subsequently aging during nighttime periods of high relative humidity. Changes in surface tension partially compensate for shifts in average molar volume to give the constant hygroscopicity observed, which implies the amount (volume fraction) of soluble material in the parent aerosol is the key composition parameter required for CCN predictions. This finding, if applicable elsewhere, may explain why CCN predictions are often found to be insensitive to assumptions of chemical composition and provides a very simple way to parameterize organic hygroscopicity in atmospheric models (i.e., κorg = 0.28ɛWSOC). Special care should be given, however, to surface tension depression from organic surfactants, as its nonlinear dependence with organic fraction may introduce biases in observed (and predicted) hygroscopicity. Finally, threshold droplet growth analysis suggests the water-soluble organics do not affect activation kinetics.

Transforming the "Valley of Death" into a "Valley of Opportunity"

NASA Technical Reports Server (NTRS)

Jedlovec, Gary J.; Merceret, Francis J.; O'Brien, T. P.; Roeder, William P.; Huddleston, Lisa L.; Bauman, William H., III

2014-01-01

Transitioning technology from research to operations (23 R2O) is difficult. The problem's importance is exemplified in the literature and in every failed attempt to do so. Although the R2O gap is often called the "valley of death", a recent a Space Weather editorial called it a "Valley of Opportunity". There are significant opportunities for space weather organizations to learn from the terrestrial experience. Dedicated R2O organizations like those of the various NOAA testbeds and collaborative "proving ground" projects take common approaches to improving terrestrial weather forecasting through the early transition of research capabilities into the operational environment. Here we present experience-proven principles for the establishment and operation of similar space weather organizations, public or private. These principles were developed and currently being demonstrated by NASA at the Applied Meteorology Unit (AMU) and the Short-term Prediction Research and Transition (SPoRT) Center. The AMU was established in 1991 jointly by NASA, the U.S. Air Force (USAF) and the National Weather Service (NWS) to provide tools and techniques for improving weather support to the Space Shuttle Program (Madura et al., 2011). The primary customers were the USAF 45th Weather Squadron (45 WS) and the NWS Spaceflight Meteorology Group (SMG who provided the weather observing and forecast support for Shuttle operations). SPoRT was established in 2002 to transition NASA satellite and remote-sensing technology to the NWS. The continuing success of these organizations suggests the common principles guiding them may be valuable for similar endeavors in the space weather arena.

Geology and undiscovered resource assessment of the potash-bearing Central Asia Salt Basin, Turkmenistan, Uzbekistan, Tajikistan, and Afghanistan: Chapter AA in Global mineral resource assessment

USGS Publications Warehouse

Wynn, Jeff; Orris, Greta J.; Dunlap, Pamela; Cocker, Mark D.; Bliss, James D.

2016-03-23

Chapter 1 of this report provides an overview of the history of the CASB and summarizes evaporite potash deposition, halokinesis, and dissolution processes that have affected the current distribution of potash-bearing salt in the CASB. Chapter 2 describes the Gissar tract, an uplifted region that contains a mix of stratabound and halokinetic potash deposits and all of the discovered and exploited potash deposits of the CASB. Chapter 3 describes the Amu Darya tract, where evaporite deposits remain flat-lying and undeformed since their original deposition. Chapter 4 describes the highly deformed and compressed Afghan-Tajik tract and what is known of the deeply-buried Jurassic salt. Chapter 5 describes the spatial databases included with this report, which contain a collection of CASB potash information. Appendixes A and B summarize descriptive models for stratabound and halokinetic potash-bearing salt deposits, respectively. Appendix C summarizes the AGE method used to evaluate the Gissar and Amu Darya tracts. Appendixes D and E contain grade and thickness data for the Gissar and Amu Darya tracts. Appendix F provides the SYSTAT script used to estimate undiscovered K2 O in a CASB tract. Appendix G provides a potash glossary, and appendix H provides biographies of assessment participants.

Understanding antimicrobial stewardship: Disease severity treatment thresholds and antimicrobial alternatives among organic and conventional calf producers.

PubMed

Habing, Greg; Djordjevic, Catherine; Schuenemann, Gustavo M; Lakritz, Jeff

2016-08-01

Reductions in livestock antimicrobial use (AMU) can be achieved through identification of effective antimicrobial alternatives as well as accurate and stringent identification of cases requiring antimicrobial therapy. Objective measurements of selectivity that incorporate appropriate case definitions are necessary to understand the need and potential for reductions in AMU through judicious use. The objective of this study was to measure selectivity using a novel disease severity treatment threshold for calf diarrhea, and identify predictors of more selective application of antimicrobials among conventional dairy producers. A second objective of this study was to describe the usage frequency and perceptions of efficacy of common antimicrobial alternatives among conventional and organic producers. The cross-sectional survey was mailed to Michigan and Ohio, USA dairy producers and contained questions on AMU attitudes, AMU practices, veterinary-written protocols, and antimicrobial alternatives. The treatment threshold, defined based on the case severity where the producer would normally apply antimicrobials, was identified with a series of descriptions with increasing severity, and ordinal multivariable logistic regression was used to determine the association between the treatment threshold and individual or herd characteristics. The response rate was 49% (727/1488). Overall, 42% of conventional producers reported any veterinary-written treatment protocol, and 27% (113/412) of conventional producers had a veterinary-written protocol for the treatment of diarrhea that included a case identification. The majority (58%, 253/437) of conventional producers, but a minority (7%) of organic producers disagreed that antibiotic use in agriculture led to resistant bacterial infections in people. Among conventional producers, the proportion of producers applying antimicrobials for therapy increased from 13% to 67% with increasing case severity. The treatment threshold was low, medium, and high for 11% (47/419), 57% (251/419), and 28% (121/419) of conventional producers, respectively. Treatment threshold was not significantly associated with the use of protocols or frequency of veterinary visits; however, individuals with more concern for the public health impact of livestock AMU had a significantly higher treatment threshold (i.e. more selective) (p<0.05). Alternative therapies were used by both organic and conventional producers, but, garlic, aloe, and "other herbal therapies" with little documented efficacy were used by a majority (>60%) of organic producers. Overall, findings from this study highlight the need for research on antimicrobial alternatives, wider application of treatment protocols, and farm personnel education and training on diagnostic criteria for initiation of antimicrobial therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

Herd-level relationship between antimicrobial use and presence or absence of antimicrobial resistance in gram-negative bovine mastitis pathogens on Canadian dairy farms.

PubMed

Saini, Vineet; McClure, J T; Scholl, Daniel T; DeVries, Trevor J; Barkema, Herman W

2013-08-01

Concurrent data on antimicrobial use (AMU) and resistance are needed to contain antimicrobial resistance (AMR) in bacteria. The present study examined a herd-level association between AMU and AMR in Escherichia coli (n=394) and Klebsiella species (n=139) isolated from bovine intramammary infections and mastitis cases on 89 dairy farms in 4 regions of Canada [Alberta, Ontario, Québec, and Maritime Provinces (Prince Edward Island, Nova Scotia, and New Brunswick)]. Antimicrobial use data were collected using inventory of empty antimicrobial containers and antimicrobial drug use rate was calculated to quantify herd-level AMU. Minimum inhibitory concentrations (MIC) were determined using Sensititre National Antimicrobial Resistance Monitoring System (NARMS) gram-negative MIC plate (Trek Diagnostic Systems Inc., Cleveland, OH). Isolates were classified as susceptible, intermediate, or resistant. Intermediate and resistant category isolates were combined to form an AMR category, and multivariable logistic regression models were built to determine herd-level odds of AMR to tetracycline, ampicillin, cefoxitin, chloramphenicol, trimethoprim-sulfamethoxazole combination, sulfisoxazole, streptomycin and kanamycin in E. coli isolates. In the case of Klebsiella species isolates, logistic regression models were built for tetracycline and sulfisoxazole; however, no associations between AMU and AMR in Klebsiella species were observed. Ampicillin-intermediate or -resistant E. coli isolates were associated with herds that used intramammarily administered cloxacillin, penicillin-novobiocin combination, and cephapirin used for dry cow therapy [odds ratios (OR)=26, 32, and 189, respectively], and intramammary ceftiofur administered for lactating cow therapy and systemically administered penicillin (OR=162 and 2.7, respectively). Use of systemically administered penicillin on a dairy farm was associated with tetracycline and streptomycin-intermediate or -resistant E. coli isolates (OR=5.6 and 2.8, respectively). Use of cephapirin and cloxacillin administered intramammarily for dry cow therapy was associated with increasing odds of having at least 1 kanamycin-intermediate or -resistant E. coli isolate at a farm (OR=8.7 and 9.3, respectively). Use of systemically administered tetracycline and ceftiofur was associated with cefoxitin-intermediate or -resistant E. coli (OR=0.13 and 0.16, respectively); however, the odds of a dairy herd having at least 1 cefoxitin-intermediate or -resistant E. coli isolate due to systemically administered ceftiofur increased with increasing average herd parity (OR=3.1). Association between herd-level AMU and AMR in bovine mastitis coliforms was observed for certain antimicrobials. Differences in AMR between different barn types and geographical regions were not observed. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Sputtered gas-phase dianions detected by high-sensitivity mass spectrometry

NASA Astrophysics Data System (ADS)

Gnaser, Hubert; Golser, Robin

2006-10-01

The detection of small doubly-charged molecular anions by means of highly sensitive mass spectrometry is discussed. The production of these gas-phase dianions is accomplished by sputtering the specimen with Cs + ions with an energy of a few keV. It is demonstrated that dianions can be detected most easily when the molecular ion has an odd total mass; then, the dianions will show up at half-integral mass numbers in the mass spectrum. In addition, the agreement of the relative abundances of several isotopomers of a dianion with the nominal isotopic pattern corroborates the identification of a dianionic species in the mass spectrum. These features are exemplified by monitoring mixed silicon-oxygen dianions of the general form OO52-[28], Sn2-[29], SiC62-[30], BeCn2-[31], and PtX62- (X = F, Cl, Br) [32]. More recent work of this group investigated the existence of long-lived dianions containing tetrahedrally coordinated oxygen atoms, namely, O(C)42- and O(BN)42-[33], of cyclic carbon cluster dianions [34], of tetraborates [35], of derivatives of the closo-hexaborate dianion BH62-[36], and of aromatic dianions [37]. Apart from identifying (meta)stable dianions, these computations indicated a possible general formation principle: small dianions are expected to be particularly stable if they consist of a central, at least partially positively charged atom and several equivalent negatively charged ligands [2,6,30,38]. Furthermore, it was pointed out [31,39,40] that for multiply charged anions a repulsive Coulomb barrier for electron emission exists which may result in small metastable dianions which can be detected by mass spectrometry. In fact, the existence of such a Coulomb barrier was inferred from various experiments [41-47]. Apart from dianions, Cederbaum and coworkers studied different small MCAs [19,24,25,48-50]. Theoretical work by other groups [51-59] corroborated and diversified these results. Following the experimental detection of Cn2-[12], several different types of other dianions were produced by means of sputtering: SiCn2- ( n = 6, 8, 10) [60], BeCn2- (4 ⩽ n ⩽ 14) [61,62], OCn2- (5 ⩽ n ⩽ 19) [63,64], SCn2- (6 ⩽ n ⩽ 18) [65], BeF42- and, MgF42-[66], CaF42-[67], HfF62-[68], ZrF62-[65], LiF32-[69], BeOn2- ( n = 4, 6), and CuBeO42-[70], as well as a few others [65,71]. However, also a considerable number of unsuccessful searches for dianions were reported [13,65,68,72]. Apart from sputtering, other ways of dianion formation were employed: Oxygen cluster (O)n2- ( n = 3, 5, 7, 9) were formed by electron attachment to an O 2 beam [73]. Electrospray ionization was used to produce various dianions, e.g., SO42-·nHO, SO62-·nHO, and SO82-·nHO[74], MX42- (M = Pd, Pt; X = Cl, Br) [43,44,75], MX62- (M = Re, Os, Ir, Pt; X = Cl, Br) [43,76], ZrF62-[77] or aliphatic dicarboxylate dianions [78-80]. While fullerene dianions (with n = 70-124) [81] and even C603- and C604-[82] could be produced by electrospray mass spectrometry, no C602- dianions were observed in these studies. Doubly-charged C602- and C702- ions have been produced also by laser desorption[83,84] or by collisions with Na atoms [85] whereas CF482-[41], C842-[42], C762-[86], and C702-[87] could be formed by electron attachment. More recently, dianions and even trianions of large metal clusters (some 30 or more constituents) could be produced by laser ablation [88] or by metal evaporation and subsequent electron attachment[89-92]. The aim of the present work is to discuss the production of dianions in the gas phase by sputtering and to describe their detection both in conventional mass spectrometers, operated at ion-beam energies of a few keV and in high-energy mass spectrometry. For the former, the pertinent aspects will be illustrated by means of a new class of molecular dianions, OO72-. Three distinct peaks at half-integral mass numbers are seen in the spectrum, at 98.5, 99.5, and 100.5 amu; their relative intensities are 1:9.0 × 10 -2:1.7 × 10 -3. Following the above argument, we can assume that these are caused by dianions with an odd total mass. Both silicon and oxygen have three stable isotopes: 28Si, 29Si, 30Si and 16O, 17O, 18O, respectively. Hence, various combinations of them can lead to an odd mass in a SiO72- dianion. Because of their (largely) different isotopic abundances, a clear identification is possible. Using a polynomial distribution to compute the abundances, the three most abundant SiO72- isotopomers with an odd total mass that can produce the peaks at these half-integral mass numbers are: 28Si229SiO72- at 98.5 amu, 28SiSiSiO72- at 99.5 amu, and 29SiSi216O72- at 100.5 amu. At 99.5 and 100.5 amu, two other isotopomers contribute to the signals: 28Si229SiO618O and 28SiSiSiO618O, but their abundances are lower by factors of 39 and 9.8, respectively. The computed relative isotopic pattern of these three mass peaks is then: 1:8.3 × 10 -2:2.2 × 10 -3. These ratios are rather close to the above given measured relative intensities of these peaks. This agreement provides essentially undisputable evidence that SiO72- dianions produced by sputtering are detected in the spectrum shown in Fig. 1. Principally, the mass peaks at the integral mass numbers 98 and 99 amu in Fig. 1 can result from any singly-charged molecular species, such as the peak at 100 amu which is due to the 28Si316O anion. However, the measured intensity ratio of the peaks at 98 and 98.5 amu (˜6.4) agrees very well with the computed abundance pattern of the 28Si316O72- and 28Si229SiO72- isotopomers (6.44). Therefore, the signal at 98 amu can be assumed to be largely due to 28Si316O72-. For the peak at 99 amu, the measured ratio relative to 98.5 is 0.94, whereas the nominal dianion ratio of 28Si230SiO72- (at 99 amu) to 28Si229SiO72- (at 98.5 amu) amounts to 0.80. This difference indicates that, apart from the dianion, another ion species contributes to the signal detected at 99 amu. Fig. 2 shows a mass spectrum in the range of the smallest OO52-; it is monitored as 28SiSiO52- at 68.5 amu. However, the intensity is too low for this species to detect other isotopomers of this kind, e.g., 29SiSiO52- at 69.5 amu. The experimental observation of this dianion corroborates the theoretical prediction of its stability by Cederbaum and coworkers some 10 years ago [28]. Using these data and similar ones for other cluster ions, their abundance distribution can be established. Fig. 3 depicts the yields of OO102-, was observed as 28Si429SiO102- at 150.5 amu. Apart from the dianions described so far also singly charged negative molecular ions were observed, containing various numbers of Si and O atoms. In the present experiment, the intensities of sputtered O-carrying molecules (charged or neutral) depend on the arrival rate of O 2-molecules at the surface. This is due to the fact that, for a fixed Cs + flux density, the value of j(O 2) determines the stationary oxygen surface coverage. (The sticking coefficient of O 2 also influences the magnitude of the coverage.) The decisive quantity is therefore the ratio of the O 2 arrival rate and of the Cs + flux density, R = j(O 2)/ j(Cs +). As the majority of sputtered species originate from the first and second monolayer of the surface, the intensities of O-carrying molecules may saturate at an oxygen coverage approaching unity. The dependence of the yields of some selected OO7- anion at high positive emission energies. A similar observation for Cn-[16] was ascribed to the fragmentation of dianion species: as a doubly-charged parent ion gains twice the energy in the accelerating field before fragmenting compared to a singly-charged ion, the decomposition process may result in singly-charged daughter ions with an energy surplus which will show up in the corresponding energy spectra at positive emission energies. The energy spectra of the two dianions SiO72- and SiO92- shown Fig. 5b also indicate the presence of tails towards "negative" energies, albeit to a lesser extent. This observation contrasts with the respective data for Cn2- dianions for which such negative excursions were absent [16]. In the present case, fragmentation processes which produce a doubly-charged daughter ion from a parent dianion, in analogy to the situation of singly-charged species, could explain this finding, but such a decay mechanism appears highly unlikely. The formation of dianions by electron attachment processes or electron transfer in gas-phase collisions near the emission site at the surface could produce such energy deficits. While ions decomposing in the accelerating region cannot pass through the spectrometer under normal operation (i.e., with the sample potential V = -4500 V), a possible problem in terms of the unambiguous detection of dianions could be envisaged: Let us, for example, consider a singly-charged SiO10- anion which, during its passage from the electrostatic to the magnetic sector, breaks up into two fragments of equal mass ( SiO5- and Si 2O 5); then, the charged daughter ion possesses the same magnetic rigidity ( ME/ q2) as the doubly-charged SiO52- and these two ion species could not be separated by the magnet; and the same would hold for any symmetrically decaying molecules. However, in the present instrument the final energy deflector in front of the detector might separate those species via their different energies. In addition, fragmentation processes will produce also other daughter ions (with unequal masses) which hence should show up in the mass spectrum at fractional mass numbers; the apparent absence of such mass peaks would then be a distinct indication that the signals detected are not due to a decomposition process. At this point, the necessity to use half-integral mass numbers for the detection of dianions by conventional (low-energy) mass spectrometry becomes obvious. Unfortunately, for several dianion species of interest the requirement that the total mass number of the molecule has to be odd cannot be fulfilled, e.g., KF32- or KCl32-. As compared to low-energy mass spectrometry, accelerator mass spectrometry (AMS) provides additional means to identify doubly-charged negative molecules. AMS allows to "analyze" a molecular dianion due to the break-up of the molecule into its atomic constituents during the stripping process in a tandem accelerator. The full strength shows up in cases for which the dianion under consideration is not part of series of similar dianionic species (such as Cn2-, OCn2-, or SinO2n+12-). Typical examples for that situation are LiF32- and CaF42-. Both could not be detected by low-energy mass spectrometry [13,68], but were later observed by AMS [67,69]. The experimental scheme will be discussed by means of one of the most coveted dianions produced by sputtering, LiF32-, which is detected as 6LiF32- at M/ q = 31.5 amu. When negative ions with M/ q = 31.5 amu are injected at the low-energy side of a tandem accelerator (running at 2.7 MV) and the high-energy side is set to detect 19F 2+, up to threefold coincidences are observed in an energy detector, cf. Fig. 6. Assuming the negative ions are in fact dianions of mass 63 amu, e.g., 6LiF32-, such a spectrum can be interpreted as follows: when a particular 6LiF32- breaks up in the stripper, each of the atomic constituents 6Li and 19F starts a history of its own. So, after some interactions with the stripper gas, a 19F will exit in charge state 2+ with a certain probability. Since the high-energy side is set to 19F 2+, it will eventually be registered in the energy detector. The total energy measured in the detector depends on the fate of the other 19F from this very dianion. If only one out of the three 19F leaves the stripper in charge state 2+ and comes into the detector, the multi-channel-analyzer counts it in the peak corresponding to the particle energy, say E1 (around channel 200 in Fig. 6, labeled 1F). If two out of the three 19F go into 2+, they may hit the detector simultaneously, yielding 2 E1 and thus contributing a peak at twice the energy (around channel 400 in Fig. 6, labeled 2F). With a certain probability, even all three 19F from one particular 6LiF32- may coincide. It is important to note that the peak-to-peak ratios would not change with source output. This is to be distinguished from pile-up, i.e., the random coincidence of 19F 2+ from different molecules. Indeed, coincidences up to three-fold are observed when ions with M/ q = 31.5 are injected into the accelerator during sputtering of LiF (enriched in 6Li to more than 90%), see Fig. 6. This observation proves that the signal at M/ q = 31.5 contains molecular ions with three 19F atoms, that must be dianions as their masses add up to 57 amu. The remaining mass must then be 6 amu which can only be 6Li. Another example, CaF42- was examined using 43CaF42- (the only isotopomer with odd total mass) with M/ q = 119/2 = 59.5 amu. Injecting ions with this mass-to-charge into the accelerator and setting the high-energy side to monitor 19F +, up to fourfold coincidences were observed in the detector [67], in agreement with expectations. However, when four 19F simultaneously arrive from a molecule with apparent mass 59.5 amu (smaller than 76 amu, i.e., F 4), the molecule can only be a dianion with mass 119 amu, and the remaining constituents must together have mass 43 amu. Whether the remainder is 43Ca (or something else, e.g., 27Al 16O) can be inferred from the additional information provided by mass scans at the low-energy side and at the high-energy side. For example, a clear peak in the count rate of 43 + must show up at the high-energy side, when negative ions with apparent mass 59.5 amu are injected. This was indeed the case. Both signatures together, the correct multiplicity of coincidences in the energy detector and the observation of the residual species of the original molecule ( 43Ca in the case of 43CaF42- and 6Li for 6LiF32-), provided the means for an unambiguous verification of the existence of those extremely elusive dianions. This approach of AMS was first employed for the detection of dianions by Middleton and Klein [15], and was applied later by other groups [67,69,105,106].

Cassini CAPS-ELS observations of carbon-based anions and aerosol growth in Titan's ionosphere

NASA Astrophysics Data System (ADS)

Desai, Ravindra; Coates, Andrew; Wellbrock, Anne; Kataria, Dhiren; Jones, Geraint; Lewis, Gethyn; Waite, J.

2016-06-01

Cassini observations of Titans ionosphere revealed an atmosphere rich in positively charged ions with masses up to > 350 amu and negatively charged ions and aerosols with mass over charge ratios as high as 13,800 amu/q. The detection of negatively charged molecules by the Cassini CAPS Electron Spectrometer (CAPS-ELS) was particularly surprising and showed how the synthesis of large aerosol-size particles takes place at altitudes much greater than previously thought. Here, we present further analysis into this CAPS-ELS dataset, through an enhanced understanding of the instrument's response function. In previous studies the intrinsic E/E energy resolution of the instrument did not allow specific species to be identified and the detections were classified into broad mass ranges. In this study we use an updated fitting procedure to show how the ELS mass spectrum can be resolved into specific peaks at multiples of carbon-based anions up to > 100 amu/q. The negatively charged ions and aerosols in Titans ionosphere increase in mass with decreasing altitude, the lightest species being observed close to Titan's exobase of ˜1,450km and heaviest species observed at altitudes < 950km. We identify key stages in this apparent growth process and report on key intermediaries which appear to trigger the rapid growth of the larger aerosol-size particles.

Addressing Antimicrobial Resistance: An Overview of Priority Actions to Prevent Suboptimal Antimicrobial Use in Food-Animal Production

PubMed Central

Lhermie, Guillaume; Gröhn, Yrjö T.; Raboisson, Didier

2017-01-01

The growing concern regarding emergence of bacteria resistant to antimicrobials and their potential for transmission to humans via animal production has led various authorities worldwide to implement measures to decrease antimicrobial use (AMU) in livestock production. These measures are influenced by those implemented in human medicine, and emphasize the importance of antimicrobial stewardship, surveillance, infection prevention and control and research. In food producing animals, unlike human medicine, antimicrobials are used to control diseases which cause economic losses. This major difference may explain the failure of the public policies implemented to control antimicrobial usage. Here we first review the specific factors influencing AMU across the farm animal sector and highlighting the farmers’ decision-making process of AMU. We then discuss the efficiency of existing regulations implemented by policy makers, and assess the need for alternative strategies, such as substitution between antimicrobials and other measures for infectious disease control. We also discuss the interests of regulating antimicrobial prices. Finally, we emphasize the value of optimizing antimicrobial regimens, and developing veterinary precision medicine to achieve clinical efficacy in animals while limiting negative impacts on public health. The fight against antimicrobial resistance requires both a reduction and an optimization of antimicrobial consumption. The set of actions currently implemented by policy makers does not adequately address the economic interests of farmers’ use of antimicrobials. PMID:28111568

Lunar Pickup Ions Observed by ARTEMIS: Spatial and Temporal Distribution and Constraints on Species and Source Locations

NASA Technical Reports Server (NTRS)

Halekas, Jasper S.; Poppe, A. R.; Delory, G. T.; Sarantos, M.; Farrell, W. M.; Angelopoulos, V.; McFadden, J. P.

2012-01-01

ARTEMIS observes pickup ions around the Moon, at distances of up to 20,000 km from the surface. The observed ions form a plume with a narrow spatial and angular extent, generally seen in a single energy/angle bin of the ESA instrument. Though ARTEMIS has no mass resolution capability, we can utilize the analytically describable characteristics of pickup ion trajectories to constrain the possible ion masses that can reach the spacecraft at the observation location in the correct energy/angle bin. We find that most of the observations are consistent with a mass range of approx. 20-45 amu, with a smaller fraction consistent with higher masses, and very few consistent with masses below 15 amu. With the assumption that the highest fluxes of pickup ions come from near the surface, the observations favor mass ranges of approx. 20-24 and approx. 36-40 amu. Although many of the observations have properties consistent with a surface or near-surface release of ions, some do not, suggesting that at least some of the observed ions have an exospheric source. Of all the proposed sources for ions and neutrals about the Moon, the pickup ion flux measured by ARTEMIS correlates best with the solar wind proton flux, indicating that sputtering plays a key role in either directly producing ions from the surface, or producing neutrals that subsequently become ionized.

ACE-SWICS In Situ Plasma Composition of Fragmented Comet 73P/Schwassmann-Wachmann 3

NASA Astrophysics Data System (ADS)

Gilbert, J. A.; Lepri, S. T.; Rubin, M.; Zurbuchen, T.

2013-12-01

The interiors of comets contain some of the most pristine material in the solar system. Comet 73P/Schwassmann-Wachmann 3, discovered in 1930 with a double nucleus, is a Jupiter-family comet with a 5.34-year period. This comet split into 5 fragments in 1995 and disintegrated into nearly 70 pieces in 2006. In May and June of 2006, recently ionized cometary particles originating from some of these fragments were collected with the ACE-SWICS sensor. Due to a combination of the close proximity of the fragments passing between ACE-SWICS and the Sun, and the instrument characteristics, unique measurements regarding the charge state composition and the elemental abundances of both cometary and heliospheric plasma were made during this time. The cometary material released from some of these fragments can be identified by the concentrations of water-group pick-up ions having a mass-per-charge of 16-18 amu/e. With a focus on Helium, Carbon, and water-group ions, we present an analysis of the cometary plasma. Charge state ratios of C+/O+ fall below 0.1 during detection of comet fragment plasma, and there is a clear increase in He+ during fragment crossings. The C/O ratio and He charge states are used to provide constraints on the activity of the cometary fragments and also the spatial distribution of the extended and ionized cometary tail.

The last large pelletron accelerator of the Herb era

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chopra, S.; Narayanan, M. M.; Joshi, R.

1999-04-26

Prof. Ray Herb pioneered the concept and design of the tandem Pelletron accelerator in the late sixties at NEC. The 15UD Pelletron at Nuclear Science Centre (NSC), upgraded for 16MV operation using compressed geometry accelerating tubes is the last such large Pelletron. It has unique features like offset and matching quadrupoles after the stripper for charge state selection inside the high voltage terminal and consequently the option of further stripping the ion species of the selected charge states at high energy dead section, and elaborate pulsing system in the pre-acceleration region consisting of a beam chopper, a travelling wave deflector,more » a light ion buncher (1-80 amu) and a heavy ion buncher (>80 amu). NSC was established as a heavy ion accelerator based inter university centre in 1985. It became operational in July 1991 to cater to the research requirements of a large user community which at present includes about fifty universities, twenty-eight colleges and a dozen other academic institutes and research laboratories. The number of users in Materials and allied sciences is about 500. Various important modifications have been made to improve the performance of the accelerator in the last seven years. These include replacement of the corona voltage grading system by a resistor based one, a pick-up loop to monitor charging system performance, conversion from basic double unit structure to singlet, installation of a spiral cavity based phase detector system with post-accelerator stripper after the analyzing magnet, and a high efficiency multi harmonic buncher. Installation of a turbo pump based stripper gas recirculation system in the terminal is also planned. A brief description of utilization of the machine will be given.« less

Farmers' attitude toward the introduction of selective dry cow therapy.

PubMed

Scherpenzeel, C G M; Tijs, S H W; den Uijl, I E M; Santman-Berends, I M G A; Velthuis, A G J; Lam, T J G M

2016-10-01

The attitude of Dutch dairy farmers toward selective dry cow treatment (SDCT) is unknown, although a favorable mindset toward application of SDCT seems crucial for successful implementation. Given the fact that blanket dry cow treatment has been strongly promoted until recently, the implementation of SDCT was expected to be quite a challenge. This study aimed to provide insight into the level of implementation of SDCT in 2013 in the Netherlands, the methods used by farmers for selection of cows for dry cow treatment (DCT), the relation between SDCT and udder health and antimicrobial usage (AMU) in 2013, and the mindset of farmers toward SDCT. In 2014, a questionnaire was conducted in a group of 177 herds included in a large-scale udder health study in 2013 and for which all clinical mastitis cases during this year were recorded. In addition, data on somatic cell count (SCC) parameters and AMU was available for these herds. The questionnaire included questions with regard to DCT with a special emphasis on farmers' attitude and mindset with regard to applying DCT in 2013. The data that were obtained from the questionnaire were combined with the data on clinical mastitis, SCC, and AMU. Descriptive statistics were used to evaluate the data and to study the association between DCT, udder health, and AMU. Univariable and multivariable logistic regression models with a logit link function were applied to evaluate potential associations between DCT and farmers' mindset. Selective DCT was taken up progressively by the farmers in our study, with 75% of them implementing SDCT in 2013. The main criterion used to select cows for DCT was the SCC history during the complete previous lactation. The herds were divided into 3 groups based on the percentage of cows dried off with antibiotics in 2013 as indicated by the farmers during interviews. The first group applied BDCT, and the herds for which SDCT was applied were split in 2 equally sized groups based on the median percentage of cows dried off with antibiotics (67%). The incidence rate of subclinical and clinical mastitis were comparable between the groups. Results of the multivariable model showed that 4 factors related to farmers' mindset were associated with the probability to apply SDCT: "financial consequences of SDCT," "uncertainty whether a cow will recover without antimicrobials," the statement "I do not have a problem with the (potential) negative consequences of SDCT," and the usage of internal teat sealants. Application of SDCT appeared to be associated with farmers' attitude. The mindset of farmers with respect to reduction of AMU and the implementation of SDCT was generally positive. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Radiation effects on late cytopathological parameters in the murine lens relative to particle fluence

NASA Astrophysics Data System (ADS)

Tao, F.; Powers-Risius, P.; Alpen, E. L.; Medvedovsky, C.; David, J.; Worgul, B. V.

1994-10-01

Lenses of mice irradiated with 250 MeV protons, 670 MeV/amu20Ne, 600 MeV/amu 56Fe, 600 MeV/amu 93Nb and 593 MeV/amu 139La ions were evaluated by analyzing cytopathological indicators which have been implicated in the cataractogenic process. The LETs ranged from 0.40 keV/μm to 953 keV/μm and fluences from 1.31 × 103/mm2 to 4.99 × 107/mm2. 60Co γ-rays were used as the reference radiation. The doses ranged from 10 to 40 cGy. The lenses were assessed 64 weeks post irradiation in order to observe the late effects of LET and dose on the target cell population of the lens epithelium. Our study shows that growth dependent pathological changes occur at the cellular level as a function of dose and LET. The shapes of the RBE-LET and RBE-dose curves are consistent with previous work on eye and other biological systems done in both our laboratory and others. The RBEmax's were estimated, for the most radiation cataract related cytological changes, MN frequency and MR disorganization, by calculating the ratio of the initial slopes of dose effect curve for various heavy ions to that of 60Co γ-ray. For each ion studied, the RBEmax derived from micronucleus (MN) frequency is similar to that derived from meridional row (MR) disorganization, suggesting that heavy ions are equally efficient at producing each type of damage. Furthermore, on a per particle basis (particle/cell nucleus), both MN frequency and MR disorganization are LET dependent indicating that these classic precataractogenic indicators are multi-gene effects. Poisson probability analysis of the particle number traversing cell nuclei (average area = 24 μm2)suggested that single nuclear traversals determine these changes. By virtue of their precataractogenic nature the data on these endpoints intimate that radiation cataract may also be the consequence of single hits. In any case, these observations are consistent with the current theory of the mechanism of radiation cataractogenesis, which proposes that genomic damage to the epithelial cells surviving the exposure is responsible for opacification.

Leak rate measurements for satellite subsystems and residual gas analysis during space environment tests. [thermal vacuum and solar simulation tests

NASA Technical Reports Server (NTRS)

Nuss, H. E.

1975-01-01

The measuring and evaluation procedure for the determination of leak rates of satellite subsystems with a quadrupole mass spectrometer, and the results of the residual gas analysis are described. The method selected for leak rate determination was placing the system into a vacuum chamber and furnishing the chamber with a mass spectrometer and calibrated leaks. The residual gas of a thermal vacuum test facility, in which the thermal balance test radiation input was simulated by a heated canister, was analyzed with the mass spectrometer in the atomic mass unit range up to 300 amu. In addition to the measurements during the space environment tests, mass spectrometric studies were performed with samples of spacecraft materials. The studies were carried out during tests for the projects HELIOS, AEROS B and SYMPHONIE.

Interpretation of the ion mass spectra in the mass range 25-35 obtained in the inner coma of Halley's comet by the HIS-sensor of the Giotto IMS Experiment

NASA Technical Reports Server (NTRS)

Geiss, J.; Altwegg, K.; Anders, E.; Balsiger, H.; Ip, W.-H.; Meier, A.; Neugebauer, M.; Rosenbauer, H.; Shelley, E. G.

1991-01-01

The IMS-HIS double-focussing mass spectrometer that flew on the Giotto spacecraft covered the mass per charge range from 12 to 56 (AMU/e). By comparing flight data, calibration data, and results of model calculations of the ion population in the inner coma, the absolute mass scale is established, and ions in the mass range 25 to 35 are identified. Ions resulting from protonation of molecules with high proton affinity are relatively abundant, enabling us to estimate relative source strengths for H2CO, CH3OH, HCN, and H2S, providing for the first time a positive in situ measurement of methanol. Also, upper limits for NO and some hydrocarbons are derived.

Energy-Dependent Ionization States of Shock-Accelerated Particles in the Solar Corona

NASA Technical Reports Server (NTRS)

Reames, Donald V.; Ng, C. K.; Tylka, A. J.

2000-01-01

We examine the range of possible energy dependence of the ionization states of ions that are shock-accelerated from the ambient plasma of the solar corona. If acceleration begins in a region of moderate density, sufficiently low in the corona, ions above about 0.1 MeV/amu approach an equilibrium charge state that depends primarily upon their speed and only weakly on the plasma temperature. We suggest that the large variations of the charge states with energy for ions such as Si and Fe observed in the 1997 November 6 event are consistent with stripping in moderately dense coronal. plasma during shock acceleration. In the large solar-particle events studied previously, acceleration occurs sufficiently high in the corona that even Fe ions up to 600 MeV/amu are not stripped of electrons.

Review of antimicrobial therapy of selected bacterial diseases in broiler chickens in Canada

PubMed Central

Agunos, Agnes; Léger, Dave; Carson, Carolee

2012-01-01

This paper reviews common therapeutic applications of antimicrobials in broiler chicken production in relation to Canadian guidelines, surveillance data, and emerging public health concerns about antimicrobial use (AMU). Escherichia coli, Clostridium perfringens, and Staphylococcus spp., were reviewed because of their animal health and economic significance. Enterococcus cecorum and Salmonella were included because of their importance in antimicrobial resistance (AMR) surveillance. This review identified that i) antimicrobials are available in Canada to treat infections by these agents, but may be through over the counter or extra-label use, ii) prevalence rates for these diseases are unknown, iii) antimicrobial use estimates in broilers are lacking, and iv) AMR has emerged in clinical isolates, though data are very sparse. This review highlights the need for surveillance of AMU and AMR in broiler chickens in Canada. PMID:23729827

Thermalization of Heavy Ions in the Solar Wind

NASA Astrophysics Data System (ADS)

Tracy, Patrick J.; Kasper, Justin C.; Zurbuchen, Thomas H.; Raines, Jim M.; Shearer, Paul; Gilbert, Jason

2015-10-01

Observations of velocity distribution functions from the Advanced Composition Explorer/Solar Wind Ion Composition Spectrometer heavy ion composition instrument are used to calculate ratios of kinetic temperature and Coulomb collisional interactions of an unprecedented 50 ion species in the solar wind. These ions cover a mass per charge range of 1-5.5 amu/e and were collected in the time range of 1998-2011. We report the first calculation of the Coulomb thermalization rate between each of the heavy ion (A > 4 amu) species present in the solar wind along with protons (H+) and alpha particles (He2+). From these rates, we find that protons are the dominant source of Coulomb collisional thermalization for heavy ions in the solar wind and use this fact to calculate a collisional age for those heavy ion populations. The heavy ion thermal properties are well organized by this collisional age, but we find that the temperature of all heavy ions does not simply approach that of protons as Coulomb collisions become more important. We show that He2+ and C6+ follow a monotonic decay toward equal temperatures with protons with increasing collisional age, but O6+ shows a noted deviation from this monotonic decay. Furthermore, we show that the deviation from monotonic decay for O6+ occurs in solar wind of all origins, as determined by its Fe/O ratio. The observed differences in heavy ion temperature behavior point toward a local heating mechanism that favors ions depending on their charge and mass.

Antimicrobial Usage and Antimicrobial Resistance in Animal Production in Southeast Asia: A Review

PubMed Central

Nhung, Nguyen T.; Cuong, Nguyen V.; Thwaites, Guy; Carrique-Mas, Juan

2016-01-01

Southeast Asia is an area of great economic dynamism. In recent years, it has experienced a rapid rise in the levels of animal product production and consumption. The region is considered to be a hotspot for infectious diseases and antimicrobial resistance (AMR). We reviewed English-language peer-reviewed publications related to antimicrobial usage (AMU) and AMR in animal production, as well as antimicrobial residues in meat and fish from 2000 to 2016, in the region. There is a paucity of data from most countries and for most bacterial pathogens. Most of the published work relates to non-typhoidal Salmonella (NTS), Escherichia coli (E. coli), and Campylobacter spp. (mainly from Vietnam and Thailand), Enterococcus spp. (Malaysia), and methicillin-resistant Staphylococcus aureus (MRSA) (Thailand). However, most studies used the disk diffusion method for antimicrobial susceptibility testing; breakpoints were interpreted using Clinical Standard Laboratory Institute (CSLI) guidelines. Statistical models integrating data from publications on AMR in NTS and E. coli studies show a higher overall prevalence of AMR in pig isolates, and an increase in levels of AMR over the years. AMU studies (mostly from Vietnam) indicate very high usage levels of most types of antimicrobials, including beta-lactams, aminoglycosides, macrolides, and quinolones. This review summarizes information about genetic determinants of resistance, most of which are transferrable (mostly plasmids and integrons). The data in this review provide a benchmark to help focus research and policies on AMU and AMR in the region. PMID:27827853

Interaction of dimethylamine with clean and partially oxidized copper surfaces

NASA Astrophysics Data System (ADS)

Kelber, J. A.; Rogers, J. W.; Banse, B. A.; Koel, B. E.

1990-05-01

The interaction of dimethylamine (DMA) with partially oxidized polycrystalline copper [Cu(poly)] and clean and partially oxidized Cu(110) between 110 and 500 K has been examined using electron stimulated desorption (ESD), high resolution electron energy loss spectroscopy (HREELS) and temperature programmed desorption (TPD). ESD mass spectra of the DMA adsorbed on O/Cu(poly) between 112 and 230 K consistently display peaks at 44 amu [(CH 3) 2N] + and 46 amu [(CH 3) 2NH-H] +, but no significant parent peak at 45 amu [(CH 3) 2NH] +, even though this last feature is prominent in the gas-phase mass spectrum. OH - is not observed at temperatures below 184 K and the yield at higher temperatures is much less than that of O +. HREELS of DMA on clean and oxygen covered Cu(110) obtained at temperatures between 100 and 320 K show characteristic vibrational spectra for molecular DMA and no OH(a) vibrational modes. TPD results show that the desorption profiles of all the major peaks in the DMA mass spectrum follow that of the parent peak with no evidence for production of H 2O. The ESD, HREELS and TPD results all indicate that DMA is molecularly and reversibly adsorbed, with no significant formation of surface hydroxyl species. The results indicate that preferential adsorption of amines from amine/epoxy mixtures onto metal oxide surfaces could passivate the surface and prevent subsequent bonding to the epoxy resin.

UCx target preparations and characterizations

NASA Astrophysics Data System (ADS)

Andrighetto, Alberto; Corradetti, Stefano; Manzolaro, Mattia; Scarpa, Daniele; Monetti, Alberto; Rossignoli, Massimo; Borgna, Francesca; Ballan, Michele; Agostini, Mattia; D'Agostini, Fabio; Ferrari, Matteo; Zenoni, Aldo

2018-05-01

The Target-Ion Source unit is the core of an ISOL-RIB facility. Many international ISOL facilities have chosen different layouts of this unit. Many research groups are involved in research and development of targets capable of dissipating high power and, at the same time, be able to have a fast isotope release. This is mandatory in order to produce beams of short half-life isotopes. The research of new materials with advanced microstructural features is crucial in this field. The design of a proper target is indeed strictly related to the obtainment of porous refractory materials, which are capable to work under extreme conditions (temperatures up to 2000 °C in high vacuum) with a high release efficiency. For SPES, the second generation Italian ISOL-RIB Facility, the target will be made of uranium carbide (UCx) in which, by fission induced by a proton beam of 40 MeV of energy (8 kW of power), isotopes in the 60-160 amu mass region are produced. The current technological developments are also crucial in the study of third generation ISOL facilities.

Development of a compact laser-based single photon ionization time-of-flight mass spectrometer

NASA Astrophysics Data System (ADS)

Tonokura, Kenichi; Kanno, Nozomu; Yamamoto, Yukio; Yamada, Hiroyuki

2010-02-01

We have developed a compact, laser-based, single photon ionization time-of-flight mass spectrometer (SPI-TOF-MS) for on-line monitoring of trace organic species. To obtain the mass spectrum, we use a nearly fragmentation-free SPI technique with 10.5 eV (118 nm) vacuum ultraviolet laser pulses generated by frequency tripling of the third harmonic of an Nd:YAG laser. The instrument can be operated in a linear TOF-MS mode or a reflectron TOF-MS mode in the coaxial design. We designed ion optics to optimize detection sensitivity and mass resolution. For data acquisition, the instrument is controlled using LabVIEW control software. The total power requirement for the vacuum unit, control electronics unit, ion optics, and detection system is approximately 100 W. We achieve a detection limit of parts per billion by volume (ppbv) for on-line trace analysis of several organic compounds. A mass resolution of 800 at about 100 amu is obtained for reflectron TOF-MS mode in a 0.35 m long instrument. The application of on-line monitoring of diesel engine exhaust was demonstrated.

Amu Darya River

Atmospheric Science Data Center

2013-04-16

... and the river waters are used intensively to irrigate cotton and other crops. During the Soviet era, large irrigation systems were developed and the region became specialized in cotton growing. Independence from the Soviet Union occurred in 1991 and is ...

Health risks from large-scale water pollution: Current trends and implications for improving drinking water quality in the lower Amu Darya drainage basin, Uzbekistan

NASA Astrophysics Data System (ADS)

Törnqvist, Rebecka; Jarsjö, Jerker

2010-05-01

Safe drinking water is a primary prerequisite to human health, well being and development. Yet, there are roughly one billion people around the world that lack access to safe drinking water supply. Health risk assessments are effective for evaluating the suitability of using various water sources as drinking water supply. Additionally, knowledge of pollutant transport processes on relatively large scales is needed to identify effective management strategies for improving water resources of poor quality. The lower Amu Darya drainage basin close to the Aral Sea in Uzbekistan suffers from physical water scarcity and poor water quality. This is mainly due to the intensive agriculture production in the region, which requires extensive freshwater withdrawals and use of fertilizers and pesticides. In addition, recurrent droughts in the region affect the surface water availability. On average 20% of the population in rural areas in Uzbekistan lack access to improved drinking water sources, and the situation is even more severe in the lower Amu Darya basin. In this study, we consider health risks related to water-borne contaminants by dividing measured substance concentrations with health-risk based guideline values from the World Health Organisation (WHO). In particular, we analyse novel results of water quality measurements performed in 2007 and 2008 in the Mejdurechye Reservoir (located in the downstream part of the Amu Darya river basin). We furthermore identify large-scale trends by comparing the Mejdurechye results to reported water quality results from a considerable stretch of the Amu Darya river basin, including drainage water, river water and groundwater. The results show that concentrations of cadmium and nitrite exceed the WHO health-risk based guideline values in Mejdurechye Reservoir. Furthermore, concentrations of the since long ago banned and highly toxic pesticides dichlorodiphenyltrichloroethane (DDT) and γ-hexachlorocyclohexane (γ-HCH) were detected in the reservoir water for the first time in a decade. However, a relatively pronounced temporal variability in concentrations was observed for many of the substances, implying that the reservoir could contain low-risk waters temporarily. Health risk factors related to lead and chromium concentrations in groundwater were up to 200 times higher than for river water. The identified major divergence in health risk between groundwater and surface water illuminates the risk of using groundwater for drinking water supply during recurrent surface water deficits in the study area. However, the severe water scarcity and lack of financial resources in the region makes the choices of alternative water supply sources limited. Due to the presence of multiple contaminants, it appears reasonable that the aggregated toxicity of contaminant mixtures should be in focus in surface and groundwater water monitoring and management in the region. Key words: Aral Sea, Drinking water, Groundwater, Health Risk, Surface Water

Upgrade Summer Severe Weather Tool

NASA Technical Reports Server (NTRS)

Watson, Leela

2011-01-01

The goal of this task was to upgrade to the existing severe weather database by adding observations from the 2010 warm season, update the verification dataset with results from the 2010 warm season, use statistical logistic regression analysis on the database and develop a new forecast tool. The AMU analyzed 7 stability parameters that showed the possibility of providing guidance in forecasting severe weather, calculated verification statistics for the Total Threat Score (TTS), and calculated warm season verification statistics for the 2010 season. The AMU also performed statistical logistic regression analysis on the 22-year severe weather database. The results indicated that the logistic regression equation did not show an increase in skill over the previously developed TTS. The equation showed less accuracy than TTS at predicting severe weather, little ability to distinguish between severe and non-severe weather days, and worse standard categorical accuracy measures and skill scores over TTS.

SiC As An Energetic Particle Detector

NASA Technical Reports Server (NTRS)

Yan, F.; Hicks, J.; Shappirio, Mark D.; Brown, S.; Smith, C.; Xin, X.; Zhao, J. H.

2005-01-01

Several new technologies have been introduced recently in the region of semiconductor material for solid state detectors (SSD). Of particular interest is silicon carbide (SIC) since its band gap is larger than that of pure silicon, reducing its dark current and making SIC capable of operating at high temperatures and more tolerant of radiation damage. But the trade off is that a higher band gap also means fewer electron hole pairs generated, and thus a smaller signal, for detecting incident radiation. To determine what the lower limit of SiC detectors to energetic particles is, we irradiated a SiC diode with particles ranging in energy from 50 keV to 1.6 MeV and masses from 1 to 16 amu. We found that the SiC detectors sensitivity was comparable to that of pure silicon, with the SiC detector being able to measure particles down to 50 keV/amu and possibly lower.

Depth-resolved photo- and ionoluminescence of LiF and Al2O3

NASA Astrophysics Data System (ADS)

Skuratov, V. A.; Kirilkin, N. S.; Kovalev, Yu. S.; Strukova, T. S.; Havanscak, K.

2012-09-01

Microluminescence and laser confocal scanning microscopy techniques have been used to study spatial distribution of F-type color centers in LiF and mechanical stress profiles in Al2O3:Cr single crystals irradiated with 1.2 MeV/amu Ar, Kr, Xe and 3 MeV/amu Kr and Bi ions. It was found that F2 and F3+-center profiles at low ion fluences correlate with ionizing energy loss profiles. With increasing ion fluence, after ion track halo overlapping, the luminescence yield is defined by radiation defects formed in elastic collisions in the end-of-range area. Stress profiles and stress tensor components in ruby crystals across swift heavy ion irradiated layers have been deduced from depth-resolved photo-stimulated spectra using piezospectroscopic effect. Experimental data show that that stresses are compressive in basal plane and tensile in perpendicular direction in all samples irradiated with high energy ions.

Ion composition in a noctilucent cloud

NASA Technical Reports Server (NTRS)

Goldberg, R. A.; Witt, G.

1976-01-01

Ion composition at mesospheric altitudes was measured and compared between high and mid-latitude sites under summer daytime conditions. Rocket-borne measurements were made with pumped quadrupole ion mass spectrometers. The mid-latitude data were obtained at Wallops Island, Virginia on June 30, 1973, at 1510 LMT. Large quantities of hydronium cluster ions were observed through 109+, with maximum concentrations at 55+ and 73+. Also, cluster ions of nitric oxide were observed through 84+. The high latitude launch occurred at Kiruna, Sweden on August 2, 1973, at 0700 LMT following visual sighting of a noctilucent cloud on the prior evening. The data near mesopause shows cluster ions, but also a preponderance of heavy ions between 90 and 145 AMU, with groupings 18 AMU apart but unrelated to the more typical cluster ions. One possible set of consistent identifications leads to iron and iron oxide hydrates. These results may suggest the presence of metallic particulates and ions which form hydrated clusters ions.

The composition of heavy molecular ions inside the ionopause of Comet Halley

NASA Technical Reports Server (NTRS)

Mitchell, David L.; Lin, R. P.; Anderson, K. A.; Carlson, C. W.; Curtis, D. W.; Korth, A.; Reme, H.; Sauvaud, J. A.; Duston, C.; Mendis, D. A.

1989-01-01

The RPA2-PICCA instrument aboard the Giotto spacecraft obtained 10-210 amu mass spectral of cold thermal molecular ions in the coma of Comet Halley. The dissociation products of the long chain formaldehyde polymer polyoxymethylene (POM) have recently been proposed as the dominant complex molecules in the coma of Comet Halley; however, POM alone cannot account for all of the features of the high resolution spectrum. An important component of the dust at Comet Halley is particles highly enriched in carbon, hydrogen, oxygen, and nitrogen relative to the composition of carbonaceous chondrites. Since this dust could be a source for the heavy molecules observed by PICCA, a search was conducted for other chemical species by determining all the molecules with mass between 20 and 120 amu which can be made from the relatively abundant C, H, O, and N, without regard to chemical structure.

Magnesium Isotopes in the Earth, Moon, Mars, and Pallasite Parent Body: High-Precision Analysis of Olivine by Laser-Ablation Multi-Collector ICPMS

NASA Technical Reports Server (NTRS)

Norman, M.; McCulloch, M.; ONeill, H.; Brandon, A.

2004-01-01

Magnesium isotopes potentially offer new insights into a diverse range of processes including evaporation and condensation in the solar nebula, melting and metasomatism in planetary interiors, and hydrothermal alteration [1,2,3,4]. Volatility-related Mg isotopic variations of up to 10 per mil/amu relative to a terrestrial standard have been found in early nebular phases interpreted as evaporation residues [1], and relatively large variations (up to 3 per mil/amu) in the terrestrial mantle have been reported recently [4]. In order to investigate possible differences in the nebular history of material contributing to the terrestrial planets, and to search for evidence of a high-temperature origin of the Moon, we have measured the magnesium isotopic composition of primitive olivines from the Earth, Moon, Mars, and pallasite parent body using laser-ablation multicollector ICPMS.

Energy spectra of cosmic-ray nuclei from 50 to 2000 GeV per amu

NASA Technical Reports Server (NTRS)

Grunsfeld, John M.; L'Heureux, Jacques; Meyer, Peter; Muller, Dietrich; Swordy, Simon P.

1988-01-01

A direct measurement of the elemental composition of cosmic rays up to energies of several TeV/amu was performed during the Spacelab 2 flight of the Space Shuttle. Results on the spectral shape for the elements C, O, Ne, Mg, Si, and Fe, obtained from this experiment, are presented. It was found that the C and O energy spectra retain a power-law spectrum in energy with an exponent Gamma of about 2.65. The Fe spectrum is flatter (Gamma of about 2.55) up to a particle energy of about 10 to the 14th eV, indicating a steady increase in the relative abundance of iron in cosmic rays up to this energy. The energy spectra of Ne, Mg, and Si are steeper than anticipated. This behavior is unexpected within current models of cosmic-ray acceleration.

Theory of the stopping power of fast multicharged ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yudin, G.L.

1991-12-01

The processes of Coulomb excitation and ionization of atoms by a fast charged particle moving along a classical trajectory are studied. The target electrons are described by the Dirac equation, while the field of the incident particle is described by the Lienard-Wiechert potential. The theory is formulated in the form most convenient for investigation of various characteristics of semiclassical atomic collisions. The theory of sudden perturbations, which is valid at high enough velocities for a high projectile charge, is employed to obtain probabilities and cross sections of the Coulomb excitation and ionization of atomic hydrogen by fast multiply charged ions.more » Based on the semiclassical sudden Born approximation, the ionization cross section and the average electronic energy loss of a fast ion in a single collision with an atom are investigated over a wide specific energy range from 500 keV/amu to 50 MeV/amu.« less

Isotopic composition of cosmic ray nitrogen at 1.5 GeV/amu

NASA Technical Reports Server (NTRS)

Dwyer, R.; Meyer, P.

1975-01-01

For any location, the earth's magnetic field acts as a filter for incoming cosmic rays, allowing only particles above a certain rigidity. The relative isotopic composition of abundant elements can be measured with a detector sensitive to the velocity of particles in the penumbra of the earth's magnetic field. In this paper, the nitrogen velocity spectrum is compared with that of carbon plus oxygen as a reference, since in this case Z-dependent effects are minimal. The form of the energy spectrum of carbon, nitrogen, and oxygen, needed for proper correction, was measured in the same experiment. The results were obtained using a scintillator-Cerenkov counter telescope with a geometric factor of 0.25 sq in sr, flown twice on high-altitude balloons from Palestine, Texas, obtaining an exposure factor of 20 sq m sr hr. Results are presented on the isotopic composition of nitrogen at about 1.5GeV/amu.

Evaluation of the 29-km Eta Model for Weather Support to the United States Space Program

NASA Technical Reports Server (NTRS)

Manobianco, John; Nutter, Paul

1997-01-01

The Applied Meteorology Unit (AMU) conducted a year-long evaluation of NCEP's 29-km mesoscale Eta (meso-eta) weather prediction model in order to identify added value to forecast operations in support of the United States space program. The evaluation was stratified over warm and cool seasons and considered both objective and subjective verification methodologies. Objective verification results generally indicate that meso-eta model point forecasts at selected stations exhibit minimal error growth in terms of RMS errors and are reasonably unbiased. Conversely, results from the subjective verification demonstrate that model forecasts of developing weather events such as thunderstorms, sea breezes, and cold fronts, are not always as accurate as implied by the seasonal error statistics. Sea-breeze case studies reveal that the model generates a dynamically-consistent thermally direct circulation over the Florida peninsula, although at a larger scale than observed. Thunderstorm verification reveals that the meso-eta model is capable of predicting areas of organized convection, particularly during the late afternoon hours but is not capable of forecasting individual thunderstorms. Verification of cold fronts during the cool season reveals that the model is capable of forecasting a majority of cold frontal passages through east central Florida to within +1-h of observed frontal passage.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meierbachtol, K.; Tovesson, F.; Shields, D.

We developed the SPectrometer for Ion DEtermination in fission Research (SPIDER) for measuring mass yield distributions of fission products from spontaneous and neutron-induced fission. The 2E–2v method of measuring the kinetic energy (E) and velocity (v) of both outgoing fission products has been utilized, with the goal of measuring the mass of the fission products with an average resolution of 1 atomic mass unit (amu). Moreover, the SPIDER instrument, consisting of detector components for time-of-flight, trajectory, and energy measurements, has been assembled and tested using 229Th and 252Cf radioactive decay sources. For commissioning, the fully assembled system measured fission productsmore » from spontaneous fission of 252Cf. Individual measurement resolutions were met for time-of-flight (250 ps FWHM), spacial resolution (2 mm FHWM), and energy (92 keV FWHM for 8.376 MeV). Finally, these mass yield results measured from 252Cf spontaneous fission products are reported from an E–v measurement.« less

Applied Meteorology Unit Quarterly Report, Second Quarter FY-13

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Shafer, Jaclyn; Huddleston, Lisa

2013-01-01

The AMU team worked on six tasks for their customers: (1) Ms. Crawford continued work on the objective lightning forecast task for airports in east-central Florida, and began work on developing a dual-Doppler analysis with local Doppler radars, (2) Ms. Shafer continued work for Vandenberg Air Force Base on an automated tool to relate pressure gradients to peak winds, (3) Dr. Huddleston continued work to develop a lightning timing forecast tool for the Kennedy Space Center/Cape Canaveral Air Force Station area, (4) Dr. Bauman continued work on a severe weather forecast tool focused on east-central Florida, (5) Mr. Decker began developing a wind pairs database for the Launch Services Program to use when evaluating upper-level winds for launch vehicles, and (6) Dr. Watson began work to assimilate observational data into the high-resolution model configurations, she created for Wallops Flight Facility and the Eastern Range.

Testing the quantum superposition principle: matter waves and beyond

NASA Astrophysics Data System (ADS)

Ulbricht, Hendrik

2015-05-01

New technological developments allow to explore the quantum properties of very complex systems, bringing the question of whether also macroscopic systems share such features, within experimental reach. The interest in this question is increased by the fact that, on the theory side, many suggest that the quantum superposition principle is not exact, departures from it being the larger, the more macroscopic the system. Testing the superposition principle intrinsically also means to test suggested extensions of quantum theory, so-called collapse models. We will report on three new proposals to experimentally test the superposition principle with nanoparticle interferometry, optomechanical devices and by spectroscopic experiments in the frequency domain. We will also report on the status of optical levitation and cooling experiments with nanoparticles in our labs, towards an Earth bound matter-wave interferometer to test the superposition principle for a particle mass of one million amu (atomic mass unit).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tracy, Patrick J.; Kasper, Justin C.; Zurbuchen, Thomas H.

Observations of velocity distribution functions from the Advanced Composition Explorer/Solar Wind Ion Composition Spectrometer heavy ion composition instrument are used to calculate ratios of kinetic temperature and Coulomb collisional interactions of an unprecedented 50 ion species in the solar wind. These ions cover a mass per charge range of 1–5.5 amu/e and were collected in the time range of 1998–2011. We report the first calculation of the Coulomb thermalization rate between each of the heavy ion (A > 4 amu) species present in the solar wind along with protons (H{sup +}) and alpha particles (He{sup 2+}). From these rates, wemore » find that protons are the dominant source of Coulomb collisional thermalization for heavy ions in the solar wind and use this fact to calculate a collisional age for those heavy ion populations. The heavy ion thermal properties are well organized by this collisional age, but we find that the temperature of all heavy ions does not simply approach that of protons as Coulomb collisions become more important. We show that He{sup 2+} and C{sup 6+} follow a monotonic decay toward equal temperatures with protons with increasing collisional age, but O{sup 6+} shows a noted deviation from this monotonic decay. Furthermore, we show that the deviation from monotonic decay for O{sup 6+} occurs in solar wind of all origins, as determined by its Fe/O ratio. The observed differences in heavy ion temperature behavior point toward a local heating mechanism that favors ions depending on their charge and mass.« less

The Beam Dynamics and Beam Related Uncertainties in Fermilab Muon $g-2$ Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Wanwei

The anomaly of the muon magnetic moment,more » $$a_{\\mu}\\equiv (g-2)/2$$, has played an important role in constraining physics beyond the Standard Model for many years. Currently, the Standard Model prediction for $$a_{\\mu}$$ is accurate to 0.42 parts per million (ppm). The most recent muon $g-2$ experiment was done at Brookhaven National Laboratory (BNL) and determined $$a_{\\mu}$$ to 0.54 ppm, with a central value that differs from the Standard Model prediction by 3.3-3.6 standard deviations and provides a strong hint of new physics. The Fermilab Muon $g-2$ Experiment has a goal to measure $$a_{\\mu}$$ to unprecedented precision: 0.14 ppm, which could provide an unambiguous answer to the question whether there are new particles and forces that exist in nature. To achieve this goal, several items have been identified to lower the systematic uncertainties. In this work, we focus on the beam dynamics and beam associated uncertainties, which are important and must be better understood. We will discuss the electrostatic quadrupole system, particularly the hardware-related quad plate alignment and the quad extension and readout system. We will review the beam dynamics in the muon storage ring, present discussions on the beam related systematic errors, simulate the 3D electric fields of the electrostatic quadrupoles and examine the beam resonances. We will use a fast rotation analysis to study the muon radial momentum distribution, which provides the key input for evaluating the electric field correction to the measured $$a_{\\mu}$$.« less

Time of flight mass spectra of ions in plasmas produced by hypervelocity impacts of organic and mineralogical microparticles on a cosmic dust analyser

NASA Astrophysics Data System (ADS)

Goldsworthy, B. J.; Burchell, M. J.; Cole, M. J.; Armes, S. P.; Khan, M. A.; Lascelles, S. F.; Green, S. F.; McDonnell, J. A. M.; Srama, R.; Bigger, S. W.

2003-10-01

The ionic plasma produced by a hypervelocity particle impact can be analysed to determine compositional information for the original particle by using a time-of-flight mass spectrometer. Such methods have been adopted on interplanetary dust detectors to perform in-situ analyses of encountered grains, for example, the Cassini Cosmic Dust Analyser (CDA). In order to more fully understand the data returned by such instruments, it is necessary to study their response to impacts in the laboratory. Accordingly, data are shown here for the mass spectra of ionic plasmas, produced through the acceleration of microparticles via a 2 MV van de Graaff accelerator and their impact on a dimensionally correct CDA model with a rhodium target. The microparticle dusts examined have three different chemical compositions: metal (iron), organic (polypyrrole and polystyrene latex) and mineral (aluminosilicate clay). These microparticles have mean diameters in the range 0.1 to 1.6 mu m and their velocities range from 1-50 km s-1. They thus cover a wide range of compositions, sizes and speeds expected for dust particles encountered by spacecraft in the Solar System. The advent of new low-density, microparticles with highly controllable attributes (composition, size) has enabled a number of new investigations in this area. The key is the use of a conducting polymer, either as the particle itself or as a thin overlayer on organic (or inorganic) core particles. This conductive coating permits efficient electrostatic charging and acceleration. Here, we examine how the projectile's chemical composition influences the ionic plasma produced after the hypervelocity impact. This study thus extends our understanding of impact plasma formation and detection. The ionization yield normalized to particle mass was found to depend on impact speed to the power (3.4 +/- 0.1) for iron and (2.9 +/- 0.1) for polypyrrole coated polystyrene and aluminosilicate clay. The ioization signal rise time was found to fall for all projectile materials from a few microseconds at low impact speeds (3 km s-1) to a few tenths of a microsecond at higher speeds (approximately 16 km s-1 for aluminosilicate particles and approximately 28 km s-1 for iron and polystyrene particles). At speeds greater than these the rise time was a constant few tenths of a microsecond independent of impact speed. The mass resolution of the time of flight spectrometer was found to be non-linear at high masses above 100 amu. It was Delta m/m = 5 for m = 1 amu and 40 for m = 200 amu. However, although at high masses most mass peaks had the resolution quoted, there were also occasional much narrower mass peaks observed, suggesting that at 250 to 280 amu Delta m/m = 80 to 100. The lower resolutions may be due to closely spaced mass peak signals effectively merging into one observed peak due to the (greater but still finite) resolution found for the isolated mass peaks. Complex mass spectra have been reproducibly obtained from a number of different projectiles that display many charged molecular fragments with masses up to 250 amu and with periodicities of 12-14 amu. These new studies reveal an extremely strong dependence of the time-of-flight mass spectra on the impact speed, particularly at low velocities (1-20 km s-1). In some impact velocity regimes it is possible to distinguish time-of-flight spectra originating from organic microparticles from those obtained from iron microparticles. However, such discrimination was not possible at high impact speeds, nor was it possible to distinguish between the time-of-flight spectra obtained for aluminosilicate particles from those obtained for iron projectiles.

The Distant Double Bond Determines the Fate of the Carboxylic Group in the Dissociative Photoionization of Oleic Acid.

PubMed

Heringa, Maarten F; Slowik, Jay G; Goldmann, Maximilian; Signorell, Ruth; Hemberger, Patrick; Bodi, Andras

2017-12-15

The valence threshold photoionization of oleic acid has been studied using synchrotron VUV radiation and imaging photoelectron photoion coincidence (iPEPICO) spectroscopy. An oleic acid aerosol beam was impacted on a copper thermodesorber, heated to 130 °C, to evaporate the particles quantitatively. Upon threshold photoionization, oleic acid produces the intact parent ion first, followed by dehydration at higher energies. Starting at ca. 10 eV, a large number of fragment ions slowly rise suggesting several fragmentation coordinates with quasi-degenerate activation energies. However, water loss is the dominant low-energy dissociation channel, and it is shown to be closely related to the unsaturated carbon chain. In the lowest-barrier process, one of the four allylic hydrogen atoms is transferred to the carboxyl group to form the leaving water molecule and a cyclic ketone fragment ion. A statistical model to analyze the breakdown diagram and measured rate constants yields a 0 K appearance energy of 9.77 eV, which can be compared with the density functional theory result of 9.19 eV. Alternative H-transfer steps yielding a terminal C=O group are ruled out based on energetics and kinetics arguments. Some of the previous photoionization mass spectrometric studies also reported 2 amu and 26 amu loss fragment ions, corresponding to hydrogen and acetylene loss. We could not identify such peaks in the mass spectrum of oleic acid. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Formation of the oxygen torus in the inner magnetosphere: Van Allen Probes observations

DOE PAGES

Nose, Masahito; Oimatsu, S.; Keika, K.; ...

2015-02-19

Here we study the formation process of an oxygen torus during the 12–15 November 2012 magnetic storm, using the magnetic field and plasma wave data obtained by Van Allen Probes. We estimate the local plasma mass density (ρ L) and the local electron number density (n eL) from the resonant frequencies of standing Alfvén waves and the upper hybrid resonance band. The average ion mass (M) can be calculated by M ~ ρ L/n eL under the assumption of quasi-neutrality of plasma. During the storm recovery phase, both Probe A and Probe B observe the oxygen torus at L =more » 3.0–4.0 and L = 3.7–4.5, respectively, on the morning side. The oxygen torus has M = 4.5–8 amu and extends around the plasmapause that is identified at L~3.2–3.9. We find that during the initial phase, M is 4–7 amu throughout the plasma trough and remains at ~1 amu in the plasmasphere, implying that ionospheric O + ions are supplied into the inner magnetosphere already in the initial phase of the magnetic storm. Numerical calculation under a decrease of the convection electric field reveals that some of thermal O + ions distributed throughout the plasma trough are trapped within the expanded plasmasphere, whereas some of them drift around the plasmapause on the dawnside. This creates the oxygen torus spreading near the plasmapause, which is consistent with the Van Allen Probes observations. We conclude that the oxygen torus identified in this study favors the formation scenario of supplying O + in the inner magnetosphere during the initial phase and subsequent drift during the recovery phase.« less

Kinetic and potential sputtering of an anorthite-like glassy thin film

DOE PAGES

Hijazi, H.; Bannister, M. E.; Meyer, H. M.; ...

2017-07-28

In this paper, we present measurements of He + and He +2 ion-induced sputtering of an anorthite-like thin film at a fixed solar wind-relevant impact energy of ~0.5 keV/amu using a quartz crystal microbalance approach (QCM) for determination of total absolute sputtering yields. He +2 ions are the most abundant multicharged ions in the solar wind, and increased sputtering by these ions in comparison to equivelocity He + ions is expected to have the biggest effect on the overall sputtering efficiency of solar wind impact on the Moon. These measurements indicate an almost 70% increase of the sputtering yield formore » doubly charged incident He ions compared to that for same velocity He + impact (14.6 amu/ion for He +2 vs. 8.7 amu/ion for He+). Using a selective sputtering model, the new QCM results presented here, together with previously published results for Ar +q ions and SRIM results for the relevant kinetic-sputtering yields, the effect due to multicharged-solar-wind-ion impact on local near-surface modification of lunar anorthite-like soil is explored. It is shown that the multicharged-solar-wind component leads to a more pronounced and significant differentiation of depleted and enriched surface elements as well as a shortening of the timescale over which such surface-compositional modifications might occur in astrophysical settings. Additionally, to validate previous and future determinations of multicharged-ion-induced sputtering enhancement for those cases where the QCM approach cannot be used, relative quadrupole mass spectrometry (QMS)-based measurements are presented for the same anorthite-like thin film as were investigated by QCM, and their suitability and limitations for charge state-enhanced yield measurements are discussed.« less

In-situ observation of Martian neutral exosphere: Results from MENCA aboard Indian Mars Orbiter Mission (MOM)

NASA Astrophysics Data System (ADS)

Bhardwaj, Anil; Pratim Das, Tirtha; Dhanya, M. B.; Thampi, Smitha V.

2016-07-01

Till very recently, the only in situ measurements of the Martian upper atmospheric composition was from the mass spectrometer experiments aboard the two Viking landers, which covered the altitude region from 120 to 200 km. Hence, the exploration by the Mars Exospheric Neutral Composition Analyser (MENCA) aboard the Mars Orbiter Mission (MOM) spacecraft of ISRO and the Neutral Gas and Ion Mass Spectrometer (NGIMS) experiment aboard the Mars Atmosphere and Volatile ENvironment (MAVEN) mission of NASA are significant steps to further understand the Martian neutral exosphere and its variability. MENCA is a quadrupole based neutral mass spectrometer which observes the radial distribution of the Martian neutral exosphere. The analysis of the data from MENCA has revealed unambiguous detection of the three major constituents, which are amu 44 (CO2), amu 28 (contributions from CO and N2) and amu 16 (atomic O), as well as a few minor species. Since MOM is in a highly elliptical orbit, the MENCA observations pertain to different local times, in the low-latitude region. Examples of such observations would be presented, and compared with NGIMS results. Emphasis would be given to the observations pertaining to high solar zenith angles and close to perihelion period. During the evening hours, the transition from CO2 to O dominated region is observed near 270 km, which is significantly different from the previous observations corresponding to sub-solar point and SZA of ~45°. The mean evening time exospheric temperature derived using these observations is 271±5 K. These are the first observations corresponding to the Martian evening hours, which would help to provide constraints to the thermal escape models.

Kinetic and potential sputtering of an anorthite-like glassy thin film

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hijazi, H.; Bannister, M. E.; Meyer, H. M.

In this paper, we present measurements of He + and He +2 ion-induced sputtering of an anorthite-like thin film at a fixed solar wind-relevant impact energy of ~0.5 keV/amu using a quartz crystal microbalance approach (QCM) for determination of total absolute sputtering yields. He +2 ions are the most abundant multicharged ions in the solar wind, and increased sputtering by these ions in comparison to equivelocity He + ions is expected to have the biggest effect on the overall sputtering efficiency of solar wind impact on the Moon. These measurements indicate an almost 70% increase of the sputtering yield formore » doubly charged incident He ions compared to that for same velocity He + impact (14.6 amu/ion for He +2 vs. 8.7 amu/ion for He+). Using a selective sputtering model, the new QCM results presented here, together with previously published results for Ar +q ions and SRIM results for the relevant kinetic-sputtering yields, the effect due to multicharged-solar-wind-ion impact on local near-surface modification of lunar anorthite-like soil is explored. It is shown that the multicharged-solar-wind component leads to a more pronounced and significant differentiation of depleted and enriched surface elements as well as a shortening of the timescale over which such surface-compositional modifications might occur in astrophysical settings. Additionally, to validate previous and future determinations of multicharged-ion-induced sputtering enhancement for those cases where the QCM approach cannot be used, relative quadrupole mass spectrometry (QMS)-based measurements are presented for the same anorthite-like thin film as were investigated by QCM, and their suitability and limitations for charge state-enhanced yield measurements are discussed.« less

Kinetic and potential sputtering of an anorthite-like glassy thin film

NASA Astrophysics Data System (ADS)

Hijazi, H.; Bannister, M. E.; Meyer, H. M.; Rouleau, C. M.; Meyer, F. W.

2017-07-01

In this paper, we present measurements of He+ and He+2 ion-induced sputtering of an anorthite-like thin film at a fixed solar wind-relevant impact energy of 0.5 keV/amu using a quartz crystal microbalance approach (QCM) for determination of total absolute sputtering yields. He+2 ions are the most abundant multicharged ions in the solar wind, and increased sputtering by these ions in comparison to equivelocity He+ ions is expected to have the biggest effect on the overall sputtering efficiency of solar wind impact on the Moon. Our measurements indicate an almost 70% increase of the sputtering yield for doubly charged incident He ions compared to that for same velocity He+ impact (14.6 amu/ion for He+2 vs. 8.7 amu/ion for He+). Using a selective sputtering model, the new QCM results presented here, together with previously published results for Ar+q ions and SRIM results for the relevant kinetic-sputtering yields, the effect due to multicharged-solar-wind-ion impact on local near-surface modification of lunar anorthite-like soil is explored. It is shown that the multicharged-solar-wind component leads to a more pronounced and significant differentiation of depleted and enriched surface elements as well as a shortening of the timescale over which such surface-compositional modifications might occur in astrophysical settings. In addition, to validate previous and future determinations of multicharged-ion-induced sputtering enhancement for those cases where the QCM approach cannot be used, relative quadrupole mass spectrometry (QMS)-based measurements are presented for the same anorthite-like thin film as were investigated by QCM, and their suitability and limitations for charge state-enhanced yield measurements are discussed.

Characterization of secondary organic aerosol from photo-oxidation of gasoline exhaust and specific sources of major components.

PubMed

Ma, Pengkun; Zhang, Peng; Shu, Jinian; Yang, Bo; Zhang, Haixu

2018-01-01

To further explore the composition and distribution of secondary organic aerosol (SOA) components from the photo-oxidation of light aromatic precursors (toluene, m-xylene, and 1,3,5-trimethylbenzene (1,3,5-TMB)) and idling gasoline exhaust, a vacuum ultraviolet photoionization mass spectrometer (VUV-PIMS) was employed. Peaks of the molecular ions of the SOA components with minimum molecular fragmentation were clearly observed from the mass spectra of SOA, through the application of soft ionization methods in VUV-PIMS. The experiments comparing the exhaust-SOA and light aromatic mixture-SOA showed that the observed distributions of almost all the predominant cluster ions in the exhaust-SOA were similar to that of the mixture-SOA. Based on the characterization experiments of SOA formed from individual light aromatic precursors, the SOA components with molecular weights of 98 and 110 amu observed in the exhaust-SOA resulted from the photo-oxidation of toluene and m-xylene; the components with a molecular weight of 124 amu were derived mainly from m-xylene; and the components with molecular weights of 100, 112, 128, 138, and 156 amu were mainly derived from 1,3,5-TMB. These results suggest that C 7 -C 9 light aromatic hydrocarbons are significant SOA precursors and that major SOA components originate from gasoline exhaust. Additionally, some new light aromatic hydrocarbon-SOA components were observed for the first time using VUV-PIMS. The corresponding reaction mechanisms were also proposed in this study to enrich the knowledge base of the formation mechanisms of light aromatic hydrocarbon-SOA compounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

Genomic instability in human lymphoid cells exposed to 1 GeV/amu Fe ions

NASA Technical Reports Server (NTRS)

Grosovsky, A.; Bethel, H.; Parks, K.; Ritter, L.; Giver, C.; Gauny, S.; Wiese, C.; Kronenberg, A.

2001-01-01

The goal of this study was to assess whether charged particle radiations of importance to spaceflight elicit genomic instability in human TK6 lymphoblasts. The incidence of genomic instability in TK6 cells was assessed 21 days after exposure to 2, 4, or 6 Fe ions (1 GeV/amu, LET= 146 keV/micrometers). Three indices of instability were used: intraclonal karyotypic heterogeneity, mutation rate analysis at the thymidine kinase (TK1) locus, and re-cloning efficiency. Fifteen of sixty clones demonstrated karyotypic heterogeneity. Five clones had multiple indicators of karyotypic change. One clone was markedly hypomutable and polyploid. Six clones were hypomutable, while 21 clones were mutators. Of these, seven were karyotypically unstable. Six clones had low re-cloning efficiencies, one of which was a mutator. All had normal karyotypes. In summary, many clones that survived exposure to a low fluence of Fe ions manifested one or more forms of genomic instability that may hasten the development of neoplasia through deletion or by recombination.

Tool for Forecasting Cool-Season Peak Winds Across Kennedy Space Center and Cape Canaveral Air Force Station (CCAFS)

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III; Roeder, William P.

2010-01-01

Peak wind speed is important element in 24-Hour and Weekly Planning Forecasts issued by 45th Weather Squadron (45 WS). Forecasts issued for planning operations at KSC/CCAFS. 45 WS wind advisories issued for wind gusts greater than or equal to 25 kt. 35 kt and 50 kt from surface to 300 ft. AMU developed cool-season (Oct - Apr) tool to help 45 WS forecast: daily peak wind speed, 5-minute average speed at time of peak wind, and probability peak speed greater than or equal to 25 kt, 35 kt, 50 kt. AMU tool also forecasts daily average wind speed from 30 ft to 60 ft. Phase I and II tools delivered as a Microsoft Excel graphical user interface (GUI). Phase II tool also delivered as Meteorological Interactive Data Display System (MIDDS) GUI. Phase I and II forecast methods were compared to climatology, 45 WS wind advisories and North American Mesoscale model (MesoNAM) forecasts in a verification data set.

An analytical model for calculating microdosimetric distributions from heavy ions in nanometer site targets.

PubMed

Czopyk, L; Olko, P

2006-01-01

The analytical model of Xapsos used for calculating microdosimetric spectra is based on the observation that straggling of energy loss can be approximated by a log-normal distribution of energy deposition. The model was applied to calculate microdosimetric spectra in spherical targets of nanometer dimensions from heavy ions at energies between 0.3 and 500 MeV amu(-1). We recalculated the originally assumed 1/E(2) initial delta electrons spectrum by applying the Continuous Slowing Down Approximation for secondary electrons. We also modified the energy deposition from electrons of energy below 100 keV, taking into account the effective path length of the scattered electrons. Results of our model calculations agree favourably with results of Monte Carlo track structure simulations using MOCA-14 for light ions (Z = 1-8) of energy ranging from E = 0.3 to 10.0 MeV amu(-1) as well as with results of Nikjoo for a wall-less proportional counter (Z = 18).

Next Generation Muon g-2 Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertzog, David W.

2015-12-02

I report on the progress of two new muon anomalous magnetic moment experiments, which are in advanced design and construction phases. The goal of Fermilab E989 is to reduce the experimental uncertainty ofmore » $$a_\\mu$$ from Brookhaven E821 by a factor of 4; that is, $$\\delta a_\\mu \\sim 16 \\times 10^{-11}$$, a relative uncertainty of 140~ppb. The method follows the same magic-momentum storage ring concept used at BNL, and pioneered previously at CERN, but muon beam preparation, storage ring internal hardware, field measuring equipment, and detector and electronics systems are all new or upgraded significantly. In contrast, J-PARC E34 will employ a novel approach based on injection of an ultra-cold, low-energy, muon beam injected into a small, but highly uniform magnet. Only a small magnetic focusing field is needed to maintain storage, which distinguishes it from CERN, BNL and Fermilab. E34 aims to roughly match the previous BNL precision in their Phase~1 installation.« less

Isotope-selective high-order interferometry with large organic molecules in free fall

NASA Astrophysics Data System (ADS)

Rodewald, Jonas; Dörre, Nadine; Grimaldi, Andrea; Geyer, Philipp; Felix, Lukas; Mayor, Marcel; Shayeghi, Armin; Arndt, Markus

2018-03-01

Interferometry in the time domain has proven valuable for matter-wave based measurements. This concept has recently been generalized to cold molecular clusters using short-pulse standing light waves which realized photo-depletion gratings, arranged in a time-domain Talbot–Lau interferometer (OTIMA). Here we extend this idea further to large organic molecules and demonstrate a new scheme to scan the emerging molecular interferogram in position space. The capability of analyzing different isotopes of the same monomer under identical conditions opens perspectives for studying the interference fringe shift as a function of time in gravitational free fall. The universality of OTIMA interferometry allows one to handle a large variety of particles. In our present work, quasi-continuous laser evaporation allows transferring fragile organic molecules into the gas phase, covering more than an order of magnitude in mass between 614 amu and 6509 amu, i.e. 300% more massive than in previous OTIMA experiments. For all masses, we find about 30% fringe visibility.

Genomic instability in human lymphoid cells exposed to 1 GeV/amu Fe ions.

PubMed

Grosovsky, A; Bethel, H; Parks, K; Ritter, L; Giver, C; Gauny, S; Wiese, C; Kronenberg, A

2001-01-01

The goal of this study was to assess whether charged particle radiations of importance to spaceflight elicit genomic instability in human TK6 lymphoblasts. The incidence of genomic instability in TK6 cells was assessed ~21 days after exposure to 2, 4, or 6 Fe ions (1 GeV/amu, LET= 146 keV/micrometers). Three indices of instability were used: intraclonal karyotypic heterogeneity, mutation rate analysis at the thymidine kinase (TK1) locus, and re-cloning efficiency. Fifteen of sixty clones demonstrated karyotypic heterogeneity. Five clones had multiple indicators of karyotypic change. One clone was markedly hypomutable and polyploid. Six clones were hypomutable, while 21 clones were mutators. Of these, seven were karyotypically unstable. Six clones had low re-cloning efficiencies, one of which was a mutator. All had normal karyotypes. In summary, many clones that survived exposure to a low fluence of Fe ions manifested one or more forms of genomic instability that may hasten the development of neoplasia through deletion or by recombination.

Transition Marshall Space Flight Center Wind Profiler Splicing Algorithm to Launch Services Program Upper Winds Tool

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2014-01-01

NASAs LSP customers and the future SLS program rely on observations of upper-level winds for steering, loads, and trajectory calculations for the launch vehicles flight. On the day of launch, the 45th Weather Squadron (45 WS) Launch Weather Officers (LWOs) monitor the upper-level winds and provide forecasts to the launch team via the AMU-developed LSP Upper Winds tool for launches at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station. This tool displays wind speed and direction profiles from rawinsondes released during launch operations, the 45th Space Wing 915-MHz Doppler Radar Wind Profilers (DRWPs) and KSC 50-MHz DRWP, and output from numerical weather prediction models.The goal of this task was to splice the wind speed and direction profiles from the 45th Space Wing (45 SW) 915-MHz Doppler radar Wind Profilers (DRWPs) and KSC 50-MHz DRWP at altitudes where the wind profiles overlap to create a smooth profile. In the first version of the LSP Upper Winds tool, the top of the 915-MHz DRWP wind profile and the bottom of the 50-MHz DRWP were not spliced, sometimes creating a discontinuity in the profile. The Marshall Space Flight Center (MSFC) Natural Environments Branch (NE) created algorithms to splice the wind profiles from the two sensors to generate an archive of vertically complete wind profiles for the SLS program. The AMU worked with MSFC NE personnel to implement these algorithms in the LSP Upper Winds tool to provide a continuous spliced wind profile.The AMU transitioned the MSFC NE algorithms to interpolate and fill data gaps in the data, implement a Gaussian weighting function to produce 50-m altitude intervals in each sensor, and splice the data together from both DRWPs. They did so by porting the MSFC NE code written with MATLAB software into Microsoft Excel Visual Basic for Applications (VBA). After testing the new algorithms in stand-alone VBA modules, the AMU replaced the existing VBA code in the LSP Upper Winds tool with the new algorithms. They then tested the code in the LSP Upper Winds tool with archived data. The tool will be delivered to the 45 WS after the 50-MHz DRWP upgrade is complete and the tool is tested with real-time data. The 50-MHz DRWP upgrade is expected to be finished in October 2014.

Measurements of H(+), He(2+), and He(+), in Corotating Interaction Regions at 1 AU

NASA Astrophysics Data System (ADS)

Chotoo, Kancham

Using the Supra-Thermal Ion Composition Spectrometer (STICS) from the SMS experiment on the WIND spacecraft, measurements of H+, He2+, and He+ were made during two corotating interacting regions (CIRs) at 1 AU. The unique energy range of STICS (6-198 keV/e) allowed simultaneous observation of the pre- and post-accelerated ions. These observations gave important clues about the source population, injection, acceleration mechanism, and ion transport in CIRs. The abundance of He2+ relative to H+ in the velocity range 2.5-6.0 times the solar wind velocity, VSW, (5-90 keV/amu) was between 0.11-0.18, which is more than double the solar wind values. However, the same ratio was observed in the suprathermal tail above 1.4 VSW in the spacecraft frame or above ~0.4 VSW in the solar wind frame. This suggests that the H+ and He2+ ions are injected equally into the CIR acceleration process from the suprathermal tail of the solar wind. At 1 AU the H+ and He2+ ions are primarily from the solar wind, but the He+ ions are interstellar pickup ions. The He+/He2+ ratio at 1 AU was ~0.15 for the same velocity range as above. However, this ratio was greater than 1.0 at 4.5 AU as measured previously (Gloeckler et al., 1994). This shows that the relative contribution of the pickup He+ ions to the seed population increases with radial distance away from the Sun. By combining data from three separate sensors on WIND (SMS-MASS, SMS-STICS, and EPACT-STEP), the extended helium distribution was presented for solar wind ions (~1 keV/amu) through energetic particles up to ~1 MeV/amu. The distribution covered 14 orders of magnitude in phase space density. This is the first time such an extended helium distribution is being reported at any radial distance. Using the Fisk and Lee (1980) model to fit the data between ~10-1000 keV/amu, the energetic particles were found to originate from 1.0-1.2 AU and not from beyond 2 AU, as is conventional believed. Anisotropy measurements were made using STICS for both the H+ and He2+ ions in the solar wind frame, and the results were compared to those made by EPACT-STEP. For both time intervals, the anisotropy directions showed significant deviations away from the average magnetic field direction in agreement with the STEP observations of Dwyer et al. (1997).

40 CFR 180.960 - Polymers; exemptions from the requirement of a tolerance.

Code of Federal Regulations, 2014 CFR

2014-07-01

...-hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a minimum of six...-hydroxypoly(oxyethylene)poly (oxypropylene) poly(oxyethylene) block copolymer; the minimum poly(oxypropylene... weight (in amu), 900,000 62386-95-2 Monophosphate ester of the block copolymer α-hydro-ω-hydroxypoly...

Phase Transition of H 2 in Subnanometer Pores Observed at 75 K

DOE PAGES

Olsen, Raina J.; Gillespie, Andrew K.; Contescu, Cristian I.; ...

2017-10-30

In this paper, we report a phase transition in H 2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5–0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H 2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H 2 is stabilized by the surface structure. Here we observe a transition at 75 Kmore » and 77–200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase. We model the low-density phase as a monolayer commensurate solid composed mostly of para-H 2 (the ground nuclear spin state, S = 0) and the high-density phase as an orientationally ordered bilayer commensurate solid composed mostly of ortho-H 2 (S = 1). We attribute the increase in density with temperature to the fact that the oblong ortho-H 2 can pack more densely. The transition is observed using two experiments. The high-density phase is associated with an increase in neutron backscatter by a factor of 7.0 ± 0.1. Normally, hydrogen produces no backscatter (scattering angle >90°). This backscatter appears along with a discontinuous increase in the excitation mass from 1.2 amu to 21.0 ± 2.3 amu, which we associate with collective nuclear spin excitations in the orientationally ordered phase. Film densities were measured using hydrogen adsorption. Finally, no phase transition was observed in H 2 adsorbed in control activated carbon materials.« less

Phase Transition of H 2 in Subnanometer Pores Observed at 75 K

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olsen, Raina J.; Gillespie, Andrew K.; Contescu, Cristian I.

In this paper, we report a phase transition in H 2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5–0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H 2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H 2 is stabilized by the surface structure. Here we observe a transition at 75 Kmore » and 77–200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase. We model the low-density phase as a monolayer commensurate solid composed mostly of para-H 2 (the ground nuclear spin state, S = 0) and the high-density phase as an orientationally ordered bilayer commensurate solid composed mostly of ortho-H 2 (S = 1). We attribute the increase in density with temperature to the fact that the oblong ortho-H 2 can pack more densely. The transition is observed using two experiments. The high-density phase is associated with an increase in neutron backscatter by a factor of 7.0 ± 0.1. Normally, hydrogen produces no backscatter (scattering angle >90°). This backscatter appears along with a discontinuous increase in the excitation mass from 1.2 amu to 21.0 ± 2.3 amu, which we associate with collective nuclear spin excitations in the orientationally ordered phase. Film densities were measured using hydrogen adsorption. Finally, no phase transition was observed in H 2 adsorbed in control activated carbon materials.« less

The SPIDER fission fragment spectrometer for fission product yield measurements

DOE PAGES

Meierbachtol, K.; Tovesson, F.; Shields, D.; ...

2015-04-01

We developed the SPectrometer for Ion DEtermination in fission Research (SPIDER) for measuring mass yield distributions of fission products from spontaneous and neutron-induced fission. The 2E–2v method of measuring the kinetic energy (E) and velocity (v) of both outgoing fission products has been utilized, with the goal of measuring the mass of the fission products with an average resolution of 1 atomic mass unit (amu). Moreover, the SPIDER instrument, consisting of detector components for time-of-flight, trajectory, and energy measurements, has been assembled and tested using 229Th and 252Cf radioactive decay sources. For commissioning, the fully assembled system measured fission productsmore » from spontaneous fission of 252Cf. Individual measurement resolutions were met for time-of-flight (250 ps FWHM), spacial resolution (2 mm FHWM), and energy (92 keV FWHM for 8.376 MeV). Finally, these mass yield results measured from 252Cf spontaneous fission products are reported from an E–v measurement.« less

Statistical Short-Range Guidance for Peak Wind Speed Forecasts at Edwards Air Force Base, CA

NASA Technical Reports Server (NTRS)

Dreher, Joseph G.; Crawford, Winifred; Lafosse, Richard; Hoeth, Brian; Burns, Kerry

2009-01-01

The peak winds near the surface are an important forecast element for space shuttle landings. As defined in the Flight Rules (FR), there are peak wind thresholds that cannot be exceeded in order to ensure the safety of the shuttle during landing operations. The National Weather Service Spaceflight Meteorology Group (SMG) is responsible for weather forecasts for all shuttle landings, and is required to issue surface average and 10-minute peak wind speed forecasts. They indicate peak winds are a challenging parameter to forecast. To alleviate the difficulty in making such wind forecasts, the Applied Meteorology Unit (AMU) developed a PC-based graphical user interface (GUI) for displaying peak wind climatology and probabilities of exceeding peak wind thresholds for the Shuttle Landing Facility (SLF) at Kennedy Space Center (KSC; Lambert 2003). However, the shuttle occasionally may land at Edwards Air Force Base (EAFB) in southern California when weather conditions at KSC in Florida are not acceptable, so SMG forecasters requested a similar tool be developed for EAFB.

Substitution pattern elucidation of hydroxypropyl Pinus pinaster (Ait.) bark polyflavonoid derivatives by ESI(-)-MS/MS.

PubMed

García Marrero, Danny E; Glasser, Wolfgang G; Pizzi, Antonio; Paczkowski, Sebastian; Laborie, Marie-Pierre G

2014-10-01

The structure of condensed tannins (CTs) from Pinus pinaster bark extract and their hydroxypropylated derivatives with four degrees of substitution (DS 1, 2, 3 and 4) has been characterized for the first time using negative-ion mode electrospray ionization tandem mass spectrometry (ESI(-)-MS/MS). The results showed that P. pinaster bark CTs possess structural homogeneity in terms of monomeric units (C(15), catechin). The oligomer sizes were detected to be dimers to heptamers. The derivatives showed typical phenyl-propyl ether mass fragmentation by substituent elimination (58 amu) and inherent C(15) flavonoid fissions. The relative abundance of the product ions revealed a preferential triple, tetra-/penta- and octa- hydroxypropylation substitution pattern in the monomer, dimer and trimer derivatives, respectively. A defined order of -OH reactivity towards propylene oxide was established by means of multistage experiments (A-ring ≥ B-ring > C-ring). A high structural heterogeneity of the modified oligomers was detected. Copyright © 2014 John Wiley & Sons, Ltd.

Weather Research and Forecasting Model Wind Sensitivity Study at Edwards Air Force Base, CA

NASA Technical Reports Server (NTRS)

Watson, Leela R.; Bauman, William H., III; Hoeth, Brian

2009-01-01

This abstract describes work that will be done by the Applied Meteorology Unit (AMU) in assessing the success of different model configurations in predicting "wind cycling" cases at Edwards Air Force Base, CA (EAFB), in which the wind speeds and directions oscillate among towers near the EAFB runway. The Weather Research and Forecasting (WRF) model allows users to choose among two dynamical cores - the Advanced Research WRF (ARW) and the Non-hydrostatic Mesoscale Model (NMM). There are also data assimilation analysis packages available for the initialization of the WRF model - the Local Analysis and Prediction System (LAPS) and the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS). Having a series of initialization options and WRF cores, as well as many options within each core, creates challenges for local forecasters, such as determining which configuration options are best to address specific forecast concerns. The goal of this project is to assess the different configurations available and determine which configuration will best predict surface wind speed and direction at EAFB.

Mars Exospheric studies with MENCA on a Mars Orbiter

NASA Astrophysics Data System (ADS)

Bhardwaj, Anil; Menca Team

2012-07-01

The study of Martian exosphere is important for understanding the escape rate of Martian atmosphere and its impact on Mars' climate change. The neutral density distribution and the composition of Martian exosphere still remain largely unexplored. There are no in-situ measurements of the Martian exosphere; only a few remote sensing measurements have been made and some modelling studies are carried out. We proposed to fly a neutral mass spectrometer, namely "MENCA" (Mars Exospheric Neutral Composition Analyser) to explore the Martian exospheric neutral density and composition at an altitude of ~500 km and above from the surface of Mars, and to study its radial and diurnal variations. MENCA is based on the technique of quadrupole mass spectrometry and has the mass range of 1-300 amu with unit mass resolution. (*) MENCA Team includes: S.V. Mohankumar, T. P. Das, P. Sreelatha, P. Pradeepkumar, B. Sunder, Amarnath Nandi, Neha Naik, G. Supriya, Vipin K. Yadav, M. B. Dhanya, R. Satheesh Thampi, G. P. Padmanabhan

Geochemistry of CI chondrites: Major and trace elements, and Cu and Zn Isotopes

NASA Astrophysics Data System (ADS)

Barrat, J. A.; Zanda, B.; Moynier, F.; Bollinger, C.; Liorzou, C.; Bayon, G.

2012-04-01

In order to check the heterogeneity of the CI chondrites and determine the average composition of this group of meteorites, we analyzed a series of six large chips (weighing between 0.6 and 1.2 g) of Orgueil prepared from five different stones. In addition, one sample from each of Ivuna and Alais was analyzed. Although the sizes of the chips used in this study were “large”, our results show evidence for minor chemical heterogeneity in Orgueil, particularly for alkali elements and U. After removal of one outlier sample, the spread of the results is considerably reduced. For most of the 46 elements analyzed in this study, the average composition calculated for Orgueil is in very good agreement with previous CI estimates. This average, obtained with a “large” mass of samples, is analytically homogeneous and is suitable for normalization purposes. Finally, the Cu and Zn isotopic ratios are homogeneously distributed within the CI parent body with a spread of less than 100 ppm per atomic mass unit (amu).

Applied Meteorology Unit (AMU) Quarterly Report Fourth Quarter FY-13

NASA Technical Reports Server (NTRS)

Bauman, William; Crawford, Winifred; Watson, Leela; Shafer, Jaclyn; Huddleston, Lisa

2013-01-01

Ms. Shafer completed the task to determine relationships between pressure gradients and peak winds at Vandenberg Air Force Base (VAFB), and began developing a climatology for the VAFB wind towers; Dr. Huddleston completed the task to develop a tool to help forecast the time of the first lightning strike of the day in the Kennedy Space Center (KSC)/Cape Canaveral Air Force Station (CCAFS) area; Dr. Bauman completed work on a severe weather forecast tool focused on the Eastern Range (ER), and also developed upper-winds analysis tools for VAFB and Wallops Fl ight Facility (WFF); Ms. Crawford processed and displayed radar data in the software she will use to create a dual-Doppler analysis over the east-central Florida and KSC/CCAFS areas; Mr. Decker completed developing a wind pairs database for the Launch Services Program to use when evaluating upper-level winds for launch vehicles; Dr. Watson continued work to assimilate observational data into the high-resolution model configurations she created for WFF and the ER.

Analysis of mutant quantity and quality in human-hamster hybrid AL and AL-179 cells exposed to 137Cs-gamma or HZE-Fe ions

NASA Technical Reports Server (NTRS)

Waldren, C.; Vannais, D.; Drabek, R.; Gustafson, D.; Kraemer, S.; Lenarczyk, M.; Kronenberg, A.; Hei, T.; Ueno, A.; Chatterjee, A. (Principal Investigator)

1998-01-01

We measured the number of mutants and the kinds of mutations induced by 137Cs-gamma and by HZE-Fe (56Fe [600 MeV/amu, LET = 190 KeV/micrometer) in standard AL human hamster hybrid cells and in a new variant hybrid, AL-179. We found that HZE-Fe was more mutagenic than 137Cs-gamma per unit dose (about 1.6 fold), but was slightly less mutagenic per mean lethal dose, DO, at both the S1 and hprt- loci of AL cells. On the other hand, HZE-Fe induced about nine fold more complex S1- mutants than 137Cs-gamma rays, 28% vs 3%. 137Cs-gamma rays induced about twice as many S1- mutants and hprt-mutants in AL-179 as in AL cells, and about nine times more of the former were complex, and potentially unstable kinds of mutations.

Range-Specific High-Resolution Mesoscale Model Setup: Data Assimilation

NASA Technical Reports Server (NTRS)

Watson, Leela R.

2014-01-01

Mesoscale weather conditions can have an adverse effect on space launch, landing, and ground processing at the Eastern Range (ER) in Florida and Wallops Flight Facility (WFF) in Virginia. During summer, land-sea interactions across Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) lead to sea breeze front formation, which can spawn deep convection that can hinder operations and endanger personnel and resources. Many other weak locally driven low-level boundaries and their interactions with the sea breeze front and each other can also initiate deep convection in the KSC/CCAFS area. Some of these other boundaries include the Indian River breeze front, Banana River breeze front, outflows from previous convection, horizontal convective rolls, convergence lines from other inland bodies of water such as Lake Okeechobee, the trailing convergence line from convergence of sea breeze fronts due to the shape of Cape Canaveral, frictional convergence lines from the islands in the Bahamas, convergence lines from soil moisture differences, convergence lines from cloud shading, and others. All these subtle weak boundary interactions often make forecasting of operationally important weather very difficult at KSC/CCAFS during the convective season (May-Oct). These convective processes often build quickly, last a short time (60 minutes or less), and occur over small distances, all of which also poses a significant challenge to the local forecasters who are responsible for issuing weather advisories, watches, and warnings. Surface winds during the transition seasons of spring and fall pose the most difficulties for the forecasters at WFF. They also encounter problems forecasting convective activity and temperature during those seasons. Therefore, accurate mesoscale model forecasts are needed to aid in their decision making. Both the ER and WFF would benefit greatly from high-resolution mesoscale model output to better forecast a variety of unique weather phenomena. Global and national scale models cannot properly resolve important local-scale weather features at each location due to their horizontal resolutions being much too coarse. Therefore, a properly tuned model at a high resolution is needed to provide improved capability. This task is a multi-year effort in which the Applied Meteorology Unit (AMU) will tune the Weather Research and Forecasting (WRF) model individually for each range. The goal of the first year, the results of which are in this report, was to tune the WRF model based on the best model resolution and run time while using reasonable computing capabilities. To accomplish this, the ER and WFF supported the tasking of the AMU to perform a number of sensitivity tests in order to determine the best model configuration for operational use at each of the ranges to best predict winds, precipitation, and temperature (Watson 2013). This task is a continuation of that work and will provide a recommended local data assimilation (DA) and numerical forecast model design optimized for the ER and WFF to support space launch activities. The model will be optimized for local weather challenges at both ranges.

40 CFR 180.960 - Polymers; exemptions from the requirement of a tolerance.

Code of Federal Regulations, 2012 CFR

2012-07-01

...-hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a minimum of six...) block copolymer; the minimum poly(oxypropylene) content is 27 moles and the minimum molecular weight (in... weight (in amu), 900,000 62386-95-2 Monophosphate ester of the block copolymer α-hydro-ω-hydroxypoly...

40 CFR 180.960 - Polymers; exemptions from the requirement of a tolerance.

Code of Federal Regulations, 2013 CFR

2013-07-01

...-hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a minimum of six... (oxypropylene) poly(oxyethylene) block copolymer; the minimum poly(oxypropylene) content is 27 moles and the... number average molecular weight (in amu), 900,000 62386-95-2 Monophosphate ester of the block copolymer α...

Imaging thermal plasma mass and velocity analyzer

NASA Astrophysics Data System (ADS)

Yau, Andrew W.; Howarth, Andrew

2016-07-01

We present the design and principle of operation of the imaging ion mass and velocity analyzer on the Enhanced Polar Outflow Probe (e-POP), which measures low-energy (1-90 eV/e) ion mass composition (1-40 AMU/e) and velocity distributions using a hemispherical electrostatic analyzer (HEA), a time-of-flight (TOF) gate, and a pair of toroidal electrostatic deflectors (TED). The HEA and TOF gate measure the energy-per-charge and azimuth of each detected ion and the ion transit time inside the analyzer, respectively, providing the 2-D velocity distribution of each major ionospheric ion species and resolving the minor ion species under favorable conditions. The TED are in front of the TOF gate and optionally sample ions at different elevation angles up to ±60°, for measurement of 3-D velocity distribution. We present examples of observation data to illustrate the measurement capability of the analyzer, and show the occurrence of enhanced densities of heavy "minor" O++, N+, and molecular ions and intermittent, high-velocity (a few km/s) upward and downward flowing H+ ions in localized regions of the quiet time topside high-latitude ionosphere.

Advantages of TOF-SIMS analysis of hydroxyapatite and fluorapatite in comparison with XRD, HR-TEM and FT-IR.

PubMed

Okazaki, Masayuki; Hirata, Isao; Matsumoto, Takuya; Takahashi, Junzo

2005-12-01

The chemical analysis of hydroxyapatite and fluorapatite was carried out using time-of-flight secondary ion mass spectrometry (TOF-SIMS). Hydroxyapatite and fluorapatite were synthesized at 80 +/- 1 degrees C and pH 7.4 +/- 0.2. Fluorapatite was better crystallized, with its (300) reflection shifted to a slightly higher angle. High-resolution transmission electron microscopy clearly revealed a typical, regular hexagonal cross section perpendicular to the c-axis for fluorapatite and a flattened hexagonal cross section for hydroxyapatite. FT-IR spectra of fluorapatite confirmed the absence of OH absorption peak--which was seen in hydroxyapatite at about 3570 cm(-1). TOF-SIMS mass spectra showed a peak at 40 amu due to calcium. In addition, a peak at 19 amu due to fluorine could be clearly seen, although the intensities of PO, PO2, and PO3 were very low. It was confirmed that TOF-SIMS clearly showed the differences between positive and negative mass spectra of hydroxyapatite and fluorapatite, especially for F-. We concluded that TOF-SIMS exhibited distinct advantages compared with other methods of analysis.

On the CO and N2 abundance in Comet Halley

NASA Technical Reports Server (NTRS)

Eberhardt, P.; Krankowsky, D.; Schulte, W.; Dolder, U.; Laemmerzahl, P.; Berthelier, J. J.; Woweries, J.; Stubbemann, U.; Hodges, R. R.; Hoffmann, J. H.

1986-01-01

The mass 28 amu/e signal observed in the neutral mode of the Giotto neutral gas mass spectrometer (NMS) is evaluated. At 1000 km from the nucleus number density n(CO)/ n(H2O) is less than or = 0.07. The production rate of CO as a parent molecule directly from the nucleus is thus less than 7% of the H2O production rate. However, CO is also produced from an extended source in the inner coma (r is less than 20,000 km) and at 20,000 km from the nucleus, for the total equivalent CO production rate 0.05 is less than or = Q(CO)/Q(H2O) is less than or = 0.15. For N2 an upper limit Q(N2)/Q(H2O) is less than or = 0.1 is derived. No parent molecule for the CO is identified in agreement with the NMS measurements. It is proposed that CO or a very short-lived parent is released in the coma from cometary dust grains, such as the CHON particles.

Anorthite sputtering by H + and Ar q+ (q = 1-9) at solar wind velocities

DOE PAGES

Hijazi, Hussein Dib; Bannister, Mark E.; Meyer, III, Harry M.; ...

2014-10-16

Here, we report sputtering measurements of anorthite-like material, taken to be representative of soils found in the lunar highlands, impacted by singly and multicharged ions representative of the solar wind. The ions investigated include protons, as well as singly and multicharged Ar ions (as proxies for the nonreactive heavy solar wind constituents), in the charge state range +1 to +9, at fixed solar wind-relevant impact velocities of 165 and 310 km/s (0.25 keV/amu and 0.5 keV/amu). A quartz microbalance approach (QCM) for determination of total sputtering yields was used. The goal of the measurements was to determine the sputtering contributionmore » of the heavy, multicharged minority solar wind constituents in comparison to that due to the dominant H + fraction. The QCM results show a yield increase of a factor of about 80 for Ar + versus H + sputtering and an enhancement by a factor of 1.67 between Ar 9+ and Ar +, which is a clear indication of a potential sputtering effect.« less

A digital FDIRC prototype for isotopic identification in astroparticle physics

NASA Astrophysics Data System (ADS)

Suh, J. E.; Marrocchesi, P. S.; Bigongiari, G.; Brogi, P.; Collazuol, G.; Sulaj, A.

2017-12-01

Experimental results obtained with a prototype of a Focused Internal Reflection Cherenkov, equipped with 16 high-granularity arrays of NUV-SiPM and tested at CERN SPS in March 2015, are discussed. The detector was exposed to relativistic ions of 13, 19 and 30 GeV/amu obtained from fragmentation of a primary Ar beam. The FDIRC included a single Fused Silica radiator bar optically connected to a cylindrical mirror and an imaging focal plane of dimensions ∼4 cm×∼3 cm, covered with a total of 1024 SiPM photosensors. It was operated in photon counting mode thanks to the excellent performance of the SiPM arrays. The complete simulation of the detector was extended to the case of a planar device with multiple bars covering a sensitive area of the order of 1 m2. MC simulation is performed to evaluate its expected mass resolution for the identification of cosmic isotopes of astrophysical interest as 9Be and 10Be at energies of several GeV/amu with the goal to extend the energy reach of the present available data.

The suitability of Tedlar bags for breath sampling in medical diagnostic research.

PubMed

Steeghs, Marco M L; Cristescu, Simona M; Harren, Frans J M

2007-01-01

Tedlar bags are tested for their suitability for breath sampling for medical diagnostic purposes. Proton-transfer reaction-mass spectrometry was used to monitor the changes in composition of various mixtures contained in custom-made black-layered Tedlar bags. Characteristic ions at m/z 88 and 95 amu reflect considerable pollution from the bag material. The pollutant found on m/z 88 amu is most probably N,N-dimethylacetamide, a latent solvent used in the production of Tedlar film. Gas composition losses during filling were found to range from 5 to 47%, depending on the compound. Once stored, the half-lives of methanol, acetaldehyde, acetone, isoprene, benzene, toluene and styrene were estimated between 5 and 13 days. Losses from breath samples (52 h after filling) were found to be less than 10%. No observable decrease was found for ethylene over 3 days, using laser-based photoacoustic detection. For the use of Tedlar bags, a standardized protocol is advised, where the time point of analysis is fixed for all samples and should be kept as close as possible to the time of sampling.

Shuttle Upper Atmosphere Mass Spectrometer Experimental Flight Results

NASA Technical Reports Server (NTRS)

Blanchard, R. C.; Ozoroski, Thomas A.; Nicholson, John Y.

1994-01-01

Calibrated pressure measurements for species with mass-to-charge ratios up to 50 amu/e(-) were obtained trom the shuttle upper atmosphere mass spectrometer experiment during re-entry on the STS-35 mission. The principal experimental objective is to obtain measurements of freestream density in the hypersonic rarefied flow flight regime. Data were collected from 180 to about 87 km. However, data above 115 km were contaminated from a source of gas emanating from pressure transdueers connected in parallel to the mass spectrometer. At lower altitudes, the pressure transducer data are compared to the mass spectrometer total pressure with excellent agreement. Near the orifice entrance, a significant amount of CO2 was generated from chemical reactions. The freestream density in the rarefied flow flight regime is calculated using an orifice pressure coefficient model based upon direct simulation Monte Carlo results. This density, when compared with the 1976 U.S. Standard Atmosphere model, exhibits the wavelike nature seen on previous flights using accelerometry. Selected spectra are presented at higher altitudes (320 km) showing the effects of the ingestion of gases from a forward fuselage fuel dump.

Applied Meteorology Unit (AMU)

NASA Technical Reports Server (NTRS)

Bauman, William; Lambert, Winifred; Case, Jonathan; Short, David; Barrett, Joe

2006-01-01

Develop climatologies of gridded CG lightning densities and frequencies of occurrence for the Melbourne, FL National Weather Service (NWS MLB) county warning area. These grids are used to create a first-guess field for the lightning threat index map that is available on the NWS MLB NASA KSCIKT website. Forecasters previously created this map from scratch. Having the climatologies as a background field will increase consistency between forecasters and decrease their workload. Delivered all files containing the lightning climatologies, the data, and the code used to create the climatologies to NWS MLB. Completed and distributed a final memorandum describing how the climatologies were created. All the files were installed on the NWS MLB computer system, and then the code was compiled and tested to ensure that it worked properly on their operating system. The climatologies and their descriptions are posted on the NWS MLB website. Forecasting Low-Level Convergent Bands Under Southeast Flow Provide guidance to operational personnel that will help improve their forecasts of cloud bands under large-scale southeast flow. When these bands occur, they can lead to cloud, rain, and thunderstorm occurrences that adversely affect launch, landing, and ground operations at Kennedy Space Center/Cape Canaveral Air Force Station (KSC/CCAFS). Completed the first draft of the final report. The conclusions from this task indicated low-level wind speed and direction, low-level high pressure ridge position, east coast sea breeze front activity and upper-level jet streak position have the greatest influence on convergent band formation and movement during southeasterly flow.

Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci.

PubMed

Ponomarev, Artem L; Costes, Sylvain V; Cucinotta, Francis A

2008-11-01

We computed probabilities to have multiple double-strand breaks (DSB), which are produced in DNA on a regional scale, and not in close vicinity, in volumes matching the size of DNA damage foci, of a large chromatin loop, and in the physical volume of DNA containing the HPRT (human hypoxanthine phosphoribosyltransferase) locus. The model is based on a Monte Carlo description of DSB formation by heavy ions in the spatial context of the entire human genome contained within the cell nucleus, as well as at the gene sequence level. We showed that a finite physical volume corresponding to a visible DNA repair focus, believed to be associated with one DSB, can contain multiple DSB due to heavy ion track structure and the DNA supercoiled topography. A corrective distribution was introduced, which was a conditional probability to have excess DSB in a focus volume, given that there was already one present. The corrective distribution was calculated for 19.5 MeV/amu N ions, 3.77 MeV/amu alpha-particles, 1000 MeV/amu Fe ions, and X-rays. The corrected initial DSB yield from the experimental data on DNA repair foci was calculated. The DSB yield based on the corrective function converts the focus yield into the DSB yield, which is comparable with the DSB yield based on the earlier PFGE experiments. The distribution of DSB within the physical limits of the HPRT gene was analyzed by a similar method as well. This corrective procedure shows the applicability of the model and empowers the researcher with a tool to better analyze focus statistics. The model enables researchers to analyze the DSB yield based on focus statistics in real experimental situations that lack one-to-one focus-to-DSB correspondance.

"Water Is Life"--Farmer Rationales and Water Saving in Khorezm, Uzbekistan: A Lifeworld Analysis

ERIC Educational Resources Information Center

Oberkircher, Lisa; Hornidge, Anna-Katharina

2011-01-01

Khorezm Province is located in the Amu Darya lowlands of Uzbekistan, where unsustainable use of irrigation water has led to the Aral Sea crisis. This study deals with the question of how farmers in Khorezm perceive water and its management and how this facilitates or prevents water conservation, or "water saving," in irrigated…

A Linguistic Analysis of Errors in the Compositions of Arba Minch University Students

ERIC Educational Resources Information Center

Tizazu, Yoseph

2014-01-01

This study reports the dominant linguistic errors that occur in the written productions of Arba Minch University (hereafter AMU) students. A sample of paragraphs was collected for two years from students ranging from freshmen to graduating level. The sampled compositions were then coded, described, and explained using error analysis method. Both…

POLYCYCLIC AROMATIC HYDROCARBON (PAH) SIZE DISTRIBUTIONS IN AEROSOLS FROM APPLIANCES OF RESIDENTIAL WOOD COMBUSTION AS DETERMINED BY DIRECT THERMAL DESORPTION - GC/MS

EPA Science Inventory

The paper describesd a direct thermal desorption (TDS) approach to determine the PAH composition (MW = 202-302 amu) in size-segregated aerosols from residential wood combustion (RWC). Six combustion tests are performed with two highly available wood fuel varieties, Douglas-fir (P...

Solar cycle variation of geosynchronous plasma mass density derived from the frequency of standing Alfvén waves

NASA Astrophysics Data System (ADS)

Takahashi, Kazue; Denton, Richard E.; Singer, Howard J.

2010-07-01

We have studied the solar cycle variation of equatorial plasma mass density ρeq in the plasma trough at geosynchronous altitude. The density was indirectly determined from the frequency, fT3, of the third harmonic of toroidal standing Alfvén waves detected over a 12 year period from 1980 to 1991 with magnetometers on five Geostationary Operational Environmental Satellites (GOES). Realistic models of the ambient magnetic field and field line mass distribution were used in numerically solving the wave equation to relate fT3 to ρeq. Scanning the magnetometer data in a 30 min time window that moved forward in 10 min steps, we obtained 228,382 fT3 samples equivalent to 1586 days of data. The detection rate of fT3 is highest (˜50%) in the prenoon sector, and fT3 and ρeq samples from this sector were used to examine their dependence on F10.7, Kp, and Dst. Overall, F10.7 exhibits the highest correlation with fT3 and ρeq, implying that the solar UV/EUV control of ion production at the ionospheric height is strongly reflected in mass density variations at geosynchronous orbit. Using 27 day medians computed excluding periods of plasmasphere expansion to geosynchronous orbit and geomagnetic storm, we obtained the empirical formula fT3 (mHz) = 38 - 0.097F10.7 and logρeq (amu cm-3) = 0.42 + 0.0039F10.7, where F10.7 is given in the solar flux units 10-22 W · m-2 · Hz-1. This last formula means that with the 27 day F10.7 in the range of 68-255 in the selected solar cycle, the mass density varied by a factor of ˜5 from ˜5 to ˜26 amu cm-3. During extremely quiet times (Kp averaged using a 3 day time scale <1), for which the plasmasphere may extend out to geosynchronous orbit, and during storm periods (Dst < -50 nT), the mass density may be enhanced beyond these values.

Calculation of the Frequency Distribution of the Energy Deposition in DNA Volumes by Heavy Ions

NASA Technical Reports Server (NTRS)

Plante, Ianik; Cicinotta, Francis A.

2012-01-01

Radiation quality effects are largely determined by energy deposition in small volumes of characteristic sizes less than 10 nm representative of short-segments of DNA, the DNA nucleosome, or molecules initiating oxidative stress in the nucleus, mitochondria, or extra-cellular matrix. On this scale, qualitatively distinct types of molecular damage are possible for high linear energy transfer (LET) radiation such as heavy ions compared to low LET radiation. Unique types of DNA lesions or oxidative damages are the likely outcome of the energy deposition. The frequency distribution for energy imparted to 1-20 nm targets per unit dose or particle fluence is a useful descriptor and can be evaluated as a function of impact parameter from an ions track. In this work, the simulation of 1-Gy irradiation of a cubic volume of 5 micron by: 1) 450 (1)H(+) ions, 300 MeV; 2) 10 (12)C(6+) ions, 290 MeV/amu and 3) (56)Fe(26+) ions, 1000 MeV/amu was done with the Monte-Carlo simulation code RITRACKS. Cylindrical targets are generated in the irradiated volume, with random orientation. The frequency distribution curves of the energy deposited in the targets is obtained. For small targets (i.e. <25 nm size), the probability of an ion to hit a target is very small; therefore a large number of tracks and targets as well as a large number of histories are necessary to obtain statistically significant results. This simulation is very time-consuming and is difficult to perform by using the original version of RITRACKS. Consequently, the code RITRACKS was adapted to use multiple CPU on a workstation or on a computer cluster. To validate the simulation results, similar calculations were performed using targets with fixed position and orientation, for which experimental data are available [5]. Since the probability of single- and double-strand breaks in DNA as function of energy deposited is well know, the results that were obtained can be used to estimate the yield of DSB, and can be extended to include other targeted or non-target effects.

Shuttle landing facility cloud cover study: Climatological analysis and two tenths cloud cover rule evaluation

NASA Technical Reports Server (NTRS)

Atchison, Michael K.; Schumann, Robin; Taylor, Greg; Warburton, John; Wheeler, Mark; Yersavich, Ann

1993-01-01

The two-tenths cloud cover rule in effect for all End Of Mission (EOM) STS landings at the Kennedy Space Center (KSC) states: 'for scattered cloud layers below 10,000 feet, cloud cover must be observed to be less than or equal to 0.2 at the de-orbit burn go/no-go decision time (approximately 90 minutes before landing time)'. This rule was designed to protect against a ceiling (below 10,000 feet) developing unexpectedly within the next 90 minutes (i.e., after the de-orbit burn decision and before landing). The Applied Meteorological Unit (AMU) developed and analyzed a database of cloud cover amounts and weather conditions at the Shuttle Landing Facility for a five-year (1986-1990) period. The data indicate the best time to land the shuttle at KSC is during the summer while the worst time is during the winter. The analysis also shows the highest frequency of landing opportunities occurs for the 0100-0600 UTC and 1300-1600 UTC time periods. The worst time of the day to land a shuttle is near sunrise and during the afternoon. An evaluation of the two-tenths cloud cover rule for most data categorizations has shown that there is a significant difference in the proportions of weather violations one and two hours subsequent to initial conditions of 0.2 and 0.3 cloud cover. However, for May, Oct., 700 mb northerly wind category, 1500 UTC category, and 1600 UTC category there is some evidence that the 0.2 cloud cover rule may be overly conservative. This possibility requires further investigation. As a result of these analyses, the AMU developed nomograms to help the Spaceflight Meteorological Group (SMG) and the Cape Canaveral Forecast Facility (CCFF) forecast cloud cover for EOM and Return to Launch Site (RTLS) at KSC. Future work will include updating the two tenths database, further analysis of the data for several categorizations, and developing a proof of concept artificial neural network to provide forecast guidance of weather constraint violations for shuttle landings.

A Comparison of Tropical Storm (TS) and Non-TS Gust Factors for Assessing Peak Wind Probabilities at the Eastern Range

NASA Technical Reports Server (NTRS)

Merceret, Francis J.; Crawford, Winifred C.

2010-01-01

Peak wind speed is an important forecast element to ensure the safety of personnel and flight hardware at Kennedy Space Center (KSC) and the Cape Canaveral Air Force Station (CCAFS) in East-Central Florida. The 45th Weather Squadron (45 WS), the organization that issues forecasts for the KSC/CCAFS area, finds that peak winds are more difficult to forecast than mean winds. This difficulty motivated the 45 WS to request two independent studies. The first (Merceret 2009) was the development of a reliable model for gust factors (GF) relating the peak to the mean wind speed in tropical storms (TS). The second (Lambert et al. 2008) was a climatological study of non-TS cool season (October-April) mean and peak wind speeds by the Applied Meteorology Unit (AMU; Bauman et al. 2004) without the use of GF. Both studies presented their statistics as functions of mean wind speed and height. Most of the few comparisons of TS and non-TS GF in the literature suggest that non-TS GF at a given height and mean wind speed are smaller than the corresponding TS GF. The investigation reported here converted the non-TS peak wind statistics calculated by the AMU to the equivalent GF statistics and compared them with the previous TS GF results. The advantage of this effort over all previously reported studies of its kind is that the TS and non-TS data were taken from the same towers in the same locations. This eliminates differing surface attributes, including roughness length and thermal properties, as a major source of variance in the comparison. The goal of this study is two-fold: to determine the relationship between the non-TS and TS GF and their standard deviations (GFSD) and to determine if models similar to those developed for TS data in Merceret (2009) could be developed for the non-TS environment. The results are consistent with the literature, but include much more detailed, quantitative information on the nature of the relationship between TS and non-TS GF and GFSD as a function of height and mean wind speed.

Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase.

PubMed

Liyasova, Mariya S; Schopfer, Lawrence M; Lockridge, Oksana

2013-03-25

Cresyl saligenin phosphate (CBDP) is a suspected causative agent of "aerotoxic syndrome", affecting pilots, crew members and passengers. CBDP is produced in vivo from ortho-containing isomers of tricresyl phosphate (TCP), a component of jet engine lubricants and hydraulic fluids. CBDP irreversibly inhibits butyrylcholinesterase (BChE) in human plasma by forming adducts on the active site serine (Ser-198). Inhibited BChE undergoes aging to release saligenin and o-cresol. The active site histidine (His-438) was hypothesized to abstract o-hydroxybenzyl moiety from the initial adduct on Ser-198. Our goal was to test this hypothesis. Mass spectral analysis of CBDP-inhibited BChE digested with Glu-C showed an o-hydroxybenzyl adduct (+106 amu) on lysine 499, a residue far from the active site, but not on His-438. Nevertheless, the nitrogen of the imidazole ring of free L-histidine formed a variety of adducts upon reaction with CBDP, including the o-hydroxybenzyl adduct, suggesting that histidine-CBDP adducts may form on other proteins. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase

PubMed Central

Liyasova, Mariya S.; Schopfer, Lawrence M.; Lockridge, Oksana

2012-01-01

Cresyl saligenin phosphate (CBDP) is a suspected causative agent of “aerotoxic syndrome”, affecting pilots, crew members and passengers. CBDP is produced in vivo from ortho-containing isomers of tricresyl phosphate (TCP), a component of jet engine lubricants and hydraulic fluids. CBDP irreversibly inhibits butyrylcholinesterase (BChE) in human plasma by forming adducts on the active site serine (Ser-198). Inhibited BChE undergoes aging to release saligenin and o-cresol. The active site histidine (His-438) was hypothesized to abstract o-hydroxybenzyl moiety from the initial adduct on Ser-198. Our goal was to test this hypothesis. Mass spectral analysis of CBDP-inhibited BChE digested with Glu-C showed an o-hydroxybenzyl adduct (+106 amu) on lysine 499, a residue far from the active site, but not on His-438. Nevertheless, the nitrogen of the imidazole ring of free L-histidine formed a variety of adducts upon reaction with CBDP, including the o-hydroxybenzyl adduct, suggesting that histidine-CBDP adducts may form on other proteins. PMID:22898212

Impact of consultant specialty on discharge decisions in patients admitted as medical emergencies to hospitals in the United Kingdom.

PubMed

Subbe, C P; Jeune, Ivan Le; Ward, D; Pradhan, S; Masterton-Smith, C

2017-02-01

The Society for Acute Medicine's Benchmarking Audit (SAMBA) annually examines Clinical Quality Indicators (CQIs) of the care of patients admitted to UK hospitals as medical emergencies. The aim of this study is to review the impact of consultant specialty on discharge decisions in the SAMBA data-set. Prospective audit of patients admitted to acute medical units (AMUs) on 25 June 2015 to participating hospitals throughout the UK with subgroup analysis. Eighty-three units submitted patient data from 3138 patients.Nearly 1845 (58%, IQR for units 50-69%) of patients were referrals from Emergency Medicine, 1072 (32%, IQR for units 24-44%) were referrals from Primary Care. The mean age was 65 (SD 20). One hundred and forty-one (4.5%) patients were admitted from care homes and 951 (30%) of patients were at least 'mildly frail' and 407 (13%) had signs of physiological instability. The median and the mean time to being seen by a doctor were 1 h 20 min and 2 h 3 min, respectively. The median and the mean time to being seen by senior specialist were 3 h 55 min and 5 h 56 min, respectively. By 72 h, 29 (1%) patients had died in the AMU, 73 were admitted to critical care units, 1297 (41%) had been discharged to their own home and 60 to nursing or residential homes. For every 100 patients seen specialists in acute medicine discharged 12 more patients than specialists from other disciplines of medicine ( P  < 0.001). The difference remained significant after adjustment for case mix. Specialist in acute care might facilitate discharge in a higher proportion of patients. © The Author 2016. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com

The Determinants of Academic Performance of under Graduate Students: In the Case of Arba Minch University Chamo Campus

ERIC Educational Resources Information Center

Yigermal, Moges Endalamaw

2017-01-01

The main objective of the paper is to investigate the determinant factors affecting the academic performance of regular undergraduate students of Arba Minch university (AMU) chamo campus students. To meet the objective, the Pearson product moment correlation statistical tool and econometrics data analysis (OLS regression) method were used with the…

Assessing Water Security in the Amu Darya River Basin, Afghanistan

DTIC Science & Technology

2006-06-16

Television 11/20/04 Turkmenistan, Uzbekistan 3 Turkmenistan and Uzbekistan sign friendship accord. Cooperation Dushanbe Tajik Avesta (WWW...center for bilateral cooperation to support counter- narcotics efforts. Security Dushanbe Avesta WWW 10/8/05 Tajikistan, Uzbekistan -1...Tajikistanis demand compensation for injury from antipersonnel mines on the Tajik-Uzbek border. Cooperation Dushanbe Avesta WWW 116 10/13/05

Determinant of Academic Performance of Under Graduate Students: In the Cause of Arba Minch University Chamo Campus

ERIC Educational Resources Information Center

Yigermal, Moges Endalamaw

2017-01-01

This study was designed to investigate the determinant factors affecting academic performance of regular undergraduate students of Arba Minch University (AMU) Chamo Campus students. The study employed the use of correlation design to establish the nature of the relationships. Data were collected from 100 respondents selected from all the 12…

TVDG LET Calculator

Science.gov Websites

Sodium Iodide Water Select your Ion from the list 1 Hydrogen 1 2 Helium 4 3 Lithium 7 4 Beryllium 9 5 . It works reasonably well for ion energies larger than ~1 MeV/amu and for ions heavier than lithium the Specified Ion in the Specified Target. Select the Target Material from the dropdown list. Select

Weather Research and Forecasting Model Wind Sensitivity Study at Edwards Air Force Base, CA

NASA Technical Reports Server (NTRS)

Watson, Leela R.; Bauman, William H., III

2008-01-01

NASA prefers to land the space shuttle at Kennedy Space Center (KSC). When weather conditions violate Flight Rules at KSC, NASA will usually divert the shuttle landing to Edwards Air Force Base (EAFB) in Southern California. But forecasting surface winds at EAFB is a challenge for the Spaceflight Meteorology Group (SMG) forecasters due to the complex terrain that surrounds EAFB, One particular phenomena identified by SMG is that makes it difficult to forecast the EAFB surface winds is called "wind cycling". This occurs when wind speeds and directions oscillate among towers near the EAFB runway leading to a challenging deorbit bum forecast for shuttle landings. The large-scale numerical weather prediction models cannot properly resolve the wind field due to their coarse horizontal resolutions, so a properly tuned high-resolution mesoscale model is needed. The Weather Research and Forecasting (WRF) model meets this requirement. The AMU assessed the different WRF model options to determine which configuration best predicted surface wind speed and direction at EAFB, To do so, the AMU compared the WRF model performance using two hot start initializations with the Advanced Research WRF and Non-hydrostatic Mesoscale Model dynamical cores and compared model performance while varying the physics options.

Thermal Programmed Desorption of C32 H 66

NASA Astrophysics Data System (ADS)

Cisternas, M.; Del Campo, V.; Cabrera, A. L.; Volkmann, U. G.; Hansen, F. Y.; Taub, H.

2011-03-01

Alkanes are of interest as prototypes for more complex molecules and membranes. In this work we study the desorption kinetics of dotriacontane C32 adsorbed on Si O2 /Si substrate. We combine in our instrument High Resolution Ellipsometry (HRE) and Thermal Programmed Desorption (TPD). C32 monolayers were deposited in high vacuum from a Knudsen cell on the substrate, monitorizing sample thickness in situ with HRE. Film thickness was in the range of up to 100 AA, forming a parallel bilayer and perpendicular C32 layer. The Mass Spectrometer (RGA) of the TPD section was detecting the shift of the desorption peaks at different heating rates applied to the sample. The mass registered with the RGA was AMU 57 for parallel and perpendicular layers, due to the abundance of this mass value in the disintegration process of C32 in the mass spectrometers ionizer. Moreover, the AMU 57 signal does not interfere with other signals coming from residual gases in the vacuum chamber. The desorption energies obtained were ΔEdes = 11,9 kJ/mol for the perpendicular bilayer and ΔEdes = 23 ,5 kJ/mol for the parallel bilayer.

The project of the mass separator of atomic nuclei produced in heavy ion induced reactions

NASA Astrophysics Data System (ADS)

Oganessian, Yu. Ts.; Shchepunov, V. A.; Dmitriev, S. N.; Itkis, M. G.; Gulbekyan, G. G.; Khabarov, M. V.; Bekhterev, V. V.; Bogomolov, S. L.; Efremov, A. A.; Pashenko, S. V.; Stepantsov, S. V.; Yeremin, A. V.; Yavor, M. I.; Kalimov, A. G.

2003-05-01

A new separator and mass analyzer, named MASHA (mass analyzer of super heavy atoms), has been designed at the Flerov Laboratory JINR Dubna to separate and measure masses of nuclei and molecules with precision better than 10 -3. The set up can work in the wide mass range from A≈20 to A≈500, its mass acceptance is as large as ±2.8%. In particular, it allows unambiguous mass identification of super heavy nuclei with a resolution better than 1 amu at the level of 300 amu. Synthesized in nuclear reactions nuclides are emitted from an ECR ion source at energy E=40 kV and charge state Q=+1. Then they pass the following steps of separation and analysis: the first section of rough separation, the second section of separation and mass analysis and the final section of separation with a 90° electrostatic deflector. In the focal plane of the device, a focal plane detector determines positions (masses) of studied nuclei. Ion optics of the analyzer, optimized up to the second order, is considered. Description of its elements and subsystems is given.

Ion composition and upstream solar wind observations at comet Giacobini-Zinner

NASA Astrophysics Data System (ADS)

Coplan, M. A.; Ogilvie, K. W.; A'Hearn, M. F.; Bochsler, P.; Geiss, J.

1987-01-01

The observations by the ion composition instrument (ICI) on the ICE spacecraft made during the encounter with comet P/Giacobini-Zinner (Ogilvie et al., 1986) are discussed in detail. Solar wind He-4(2+) kinetic temperatures, densities, and velocities before, during, and after the encounter are presented. These data combined with He-4(2+) velocity distributions provide evidence for the existence of a thick diffuse shock. Relative abundances of water group ions and CO(+) are derived along with an estimate of the abundance of an ion with M/Q = 24 + or - 1 amu/e. The ICI data are compared with electron data from two other experiments (Bame et al., 1986; Meyer-Vernet et al., 1986) and found to be in reasonable agreement in the region outside the tail. Spectroscopic data for several neutral and ionic species are compared with the ICI results for the water group ions and CO(+). The spectroscopic data are also used to eliminate Mg(+) and CN(+) as candidates for the M/Q = 24 peak. The two most likely candidates are C2(+) and Na(+), but neither photoionization of parent neutrals nor sputtering from dust grains is sufficient to explain the observed abundance relative to H2O(+).

Charge exchange of highly charged argon ions as a function of projectile energy

NASA Astrophysics Data System (ADS)

Allen, F. I.; Biedermann, C.; Radtke, R.; Fussmann, G.

2007-03-01

X-ray emission of highly charged argon ions following charge exchange collisions with argon atoms has been measured as a function of projectile energy. The ions are extracted from the Electron Beam Ion Trap (EBIT) in Berlin and selected according to their massto-charge ratios. Experiments focussed on hydrogen-like and bare argon ions which were decelerated from 125q eV/amu to below 0.25q eV/amu prior to interaction with an argon gas target. The x-ray spectra recorded probe the cascading transitions resulting from electron capture into Rydberg states and are found to vary significantly with collision velocity. This indicates a shift in the orbital angular momentum of the capture state. Hardness ratios are observed to increase with decreasing projectile energy though at a rate which differs from the results of simulations. For comparison, measurements of the x-ray emission following charge exchange within the trap were carried out and are in agreement with the findings of the EBIT group at LLNL. Both of these in situ measurements, however, are in discrepancy with the results of the experiments using extracted ions.

Ion Composition in Saturn's Plasma Environment: Early Results from the Cassini Plasma Spectrometer

NASA Technical Reports Server (NTRS)

Reisenfeld, D. B.; Baragiola, R. A.; Crary, F. J.; Coates, A. J.; Goldstein, R.; Hill, T. W.; Johnson, R. E.; McComas, D. J.; Sittler, E. C.; Shappirio, M. D.

2005-01-01

Prior to Cassini s arrival at Saturn, most of what was known about the composition of the plasma in Saturn s environment was derived from limited measurements by Pioneer 11 and Voyager 1 and 2 in 1979-1981[1-3]. The measurements reported here were made by the Cassini Plasma Spectrometer (CAPS) [4] during the first two Cassini orbits, including the closest approach to Saturn and the rings during the tour, and a close flyby of Titan. The CAPS instrument resolves ion energy/charge from 1 V to 50 kV and ion mass/charge from 1 to approx.100 amu/e, and it measures electron energy from 1 eV to 28 keV. Initial composition measurements of Saturn s magnetosphere show that protons dominate outside approx.8 R(sub s), while inside this radius the plasma is dominated by a mix of water-derived ions and N(+). Over the A and B rings a plasma layer is observed composed of O2(+) and O(+) . The close passage near Titan shows a rich network of both positive and negative molecular ions. We report preliminary analysis of these and other composition findings.

Charging of dust grains in a plasma with negative ions

NASA Astrophysics Data System (ADS)

Kim, Su-Hyun; Merlino, Robert L.

2006-05-01

The effect of negative ions on the charging of dust particles in a plasma is investigated experimentally. A plasma containing a very low percentage of electrons is formed in a single-ended SF6 is admitted into the vacuum system. The relatively cold (Te≈0.2eV ) readily attach to SF6 molecules to form SF6- negative ions. Calculations of the dust charge indicate that for electrons, negative ions, and positive ions of comparable temperatures, the charge (or surface potential) of the dust can be positive if the positive ion mass is smaller than the negative ion mass and if ɛ, the ratio of the electron to positive ion density, is sufficiently small. The K+ positive ions (mass 39amu) and SF6- negative ions (mass 146amu), and also utilizes a rotating cylinder to dispense dust into the plasma column. Analysis of the current-voltage characteristics of a Langmuir probe in the dusty plasma shows evidence for the reduction in the (magnitude) of the negative dust charge and the transition to positively charged dust as the relative concentration of the residual electrons is reduced. Some remarks are offered concerning experiments that could become possible in a dusty plasma with positive grains.

Late skin damage in rabbits and monkeys after exposure to particulate radiations

NASA Technical Reports Server (NTRS)

Bergtold, D. S.; Cox, A. B.; Lett, J. T.; Su, C. M.

1983-01-01

Preliminary results are reported of experiments on the late effects of exposure to particulate radiations on stem cell populations. Skin biopsies were taken from the ears of rabbits irradiated 2-5 years previously with 530 MeV/amu Ar ions (LET 90 keV/micron), or 365 MeV/amu Ne ions (LET 35 keV micron), and from the chests and inner thighs of rhesus monkeys irradiated 16-18 years previously with 32-MeV protons (LET about 1.2 keV/micron). Skin fibroblast cultures obtained from the biopsy samples in rabbits were observed to undergo dose-dependent decreases in in vitro life span, with estimated survival curves showing the effects of Ar-ion irradiation to be more severe than those of Ne-ion irradiation. In addition, the healing of the biopsy wound was observed to become slower as radiation dose increased. In the monkey, radiation reduced the average number of fibroblasts at the time of cessation of growth in culture. Results thus demonstrate the capacity of skin sampling to reveal stem cell destruction, and have important implications for astronauts and other persons at risk of particle exposure with regard to healing responses to trauma or surgery.

Developing a Peak Wind Probability Forecast Tool for Kennedy Space Center and Cape Canaveral Air Force Station

NASA Technical Reports Server (NTRS)

Lambert, WInifred; Roeder, William

2007-01-01

This conference presentation describes the development of a peak wind forecast tool to assist forecasters in determining the probability of violating launch commit criteria (LCC) at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) in east-central Florida. The peak winds are an important forecast element for both the Space Shuttle and Expendable Launch Vehicle (ELV) programs. The LCC define specific peak wind thresholds for each launch operation that cannot be exceeded in order to ensure the safety of the vehicle. The 45th Weather Squadron (45 WS) has found that peak winds are a challenging parameter to forecast, particularly in the cool season months of October through April. Based on the importance of forecasting peak winds, the 45 WS tasked the Applied Meteorology Unit (AMU) to develop a short-range peak-wind forecast tool to assist in forecasting LCC violations. The tool will include climatologies of the 5-minute mean and peak winds by month, hour, and direction, and probability distributions of the peak winds as a function of the 5-minute mean wind speeds.

Statistical Short-Range Guidance for Peak Wind Forecasts on Kennedy Space Center/Cape Canaveral Air Force Station, Phase III

NASA Technical Reports Server (NTRS)

Crawford, Winifred

2010-01-01

This final report describes the development of a peak wind forecast tool to assist forecasters in determining the probability of violating launch commit criteria (LCC) at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). The peak winds are an important forecast element for both the Space Shuttle and Expendable Launch Vehicle (ELV) programs. The LCC define specific peak wind thresholds for each launch operation that cannot be exceeded in order to ensure the safety of the vehicle. The 45th Weather Squadron (45 WS) has found that peak winds are a challenging parameter to forecast, particularly in the cool season months of October through April. Based on the importance of forecasting peak winds, the 45 WS tasked the Applied Meteorology Unit (AMU) to develop a short-range peak-wind forecast tool to assist in forecasting LCC violations.The tool includes climatologies of the 5-minute mean and peak winds by month, hour, and direction, and probability distributions of the peak winds as a function of the 5-minute mean wind speeds.

A Peak Wind Probability Forecast Tool for Kennedy Space Center and Cape Canaveral Air Force Station

NASA Technical Reports Server (NTRS)

Crawford, Winifred; Roeder, William

2008-01-01

This conference abstract describes the development of a peak wind forecast tool to assist forecasters in determining the probability of violating launch commit criteria (LCC) at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) in east-central Florida. The peak winds are an important forecast element for both the Space Shuttle and Expendable Launch Vehicle (ELV) programs. The LCC define specific peak wind thresholds for each launch operation that cannot be exceeded in order to ensure the safety of the vehicle. The 45th Weather Squadron (45 WS) has found that peak winds are a challenging parameter to forecast, particularly in the cool season months of October through April. Based on the importance of forecasting peak winds, the 45 WS tasked the Applied Meteorology Unit (AMU) to develop a short-range peak-wind forecast tool to assist in forecasting LCC violatioas.The tool will include climatologies of the 5-minute mean end peak winds by month, hour, and direction, and probability distributions of the peak winds as a function of the 5-minute mean wind speeds.

Peak Wind Forecasts for the Launch-Critical Wind Towers on Kennedy Space Center/Cape Canaveral Air Force Station, Phase IV

NASA Technical Reports Server (NTRS)

Crawford, Winifred

2011-01-01

This final report describes the development of a peak wind forecast tool to assist forecasters in determining the probability of violating launch commit criteria (LCC) at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). The peak winds arc an important forecast clement for both the Space Shuttle and Expendable Launch Vehicle (ELV) programs. The LCC define specific peak wind thresholds for each launch operation that cannot be exceeded in order to ensure the safety of the vehicle. The 45th Weather Squadron (45 WS) has found that peak winds are a challenging parameter to forecast, particularly in the cool season months of October through April. Based on the importance of forecasting peak winds, the 45 WS tasked the Applied Meteorology Unit (AMU) to update the statistics in the current peak-wind forecast tool to assist in forecasting LCC violations. The tool includes onshore and offshore flow climatologies of the 5-minute mean and peak winds and probability distributions of the peak winds as a function of the 5-minute mean wind speeds.

Creating Interactive Graphical Overlays in the Advanced Weather Interactive Processing System (AWIPS) Using Shapefiles and DGM Files

NASA Technical Reports Server (NTRS)

Barrett, Joe H., III; Lafosse, Richard; Hood, Doris; Hoeth, Brian

2007-01-01

Graphical overlays can be created in real-time in the Advanced Weather Interactive Processing System (AWIPS) using shapefiles or DARE Graphics Metafile (DGM) files. This presentation describes how to create graphical overlays on-the-fly for AWIPS, by using two examples of AWIPS applications that were created by the Applied Meteorology Unit (AMU). The first example is the Anvil Threat Corridor Forecast Tool, which produces a shapefile that depicts a graphical threat corridor of the forecast movement of thunderstorm anvil clouds, based on the observed or forecast upper-level winds. This tool is used by the Spaceflight Meteorology Group (SMG) and 45th Weather Squadron (45 WS) to analyze the threat of natural or space vehicle-triggered lightning over a location. The second example is a launch and landing trajectory tool that produces a DGM file that plots the ground track of space vehicles during launch or landing. The trajectory tool can be used by SMG and the 45 WS forecasters to analyze weather radar imagery along a launch or landing trajectory. Advantages of both file types will be listed.

Assessment of undiscovered technically recoverable conventional petroleum resources of northern Afghanistan

USGS Publications Warehouse

Klett, T.R.; Ulmishek, G.F.; Wandrey, C.J.; Agena, Warren F.; Steinshouer, Douglas

2006-01-01

Using a geology-based assessment methodology, the U.S. Geological Survey - Afghanistan Ministry of Mines and Industry Joint Oil and Gas Resource Assessment Team estimated mean volumes of undiscovered petroleum in northern Afghanistan; the resulting estimates are 1.6 billion barrels (0.2 billion metric tons) of crude oil, 16 trillion cubic feet (0.4 trillion cubic meters) of natural gas, and 0.5 billion barrels (0.8 billion metric tons) of natural gas liquids. Most of the undiscovered crude oil is in the Afghan-Tajik Basin and most of the undiscovered natural gas is in the Amu Darya Basin. Four total petroleum systems were identified, and these were subdivided into eight assessment units for the purpose of this resource assessment. The area with the greatest potential for undiscovered natural gas accumulations is in Upper Jurassic carbonate and reef reservoirs beneath an impermeable salt layer in relatively unexplored parts of northern Afghanistan. The Afghan-Tajik Basin has the greatest potential for undiscovered crude oil accumulations, and these are potentially in Cretaceous to Paleogene carbonate reservoir rocks associated with thrust faulting and folding.

Weather Research and Forecasting Model Sensitivity Comparisons for Warm Season Convective Initiation

NASA Technical Reports Server (NTRS)

Watson, Leela R.

2007-01-01

This report describes the work done by the Applied Meteorology Unit (AMU) in assessing the success of different model configurations in predicting warm season convection over East-Central Florida. The Weather Research and Forecasting Environmental Modeling System (WRF EMS) software allows users to choose among two dynamical cores - the Advanced Research WRF (ARW) and the Non-hydrostatic Mesoscale Model (NMM). There are also data assimilation analysis packages available for the initialization of the WRF model - the Local Analysis and Prediction System (LAPS) and the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS). Besides model core and initialization options, the WRF model can be run with one- or two-way nesting. Having a series of initialization options and WRF cores, as well as many options within each core, creates challenges for local forecasters, such as determining which configuration options are best to address specific forecast concerns. This project assessed three different model intializations available to determine which configuration best predicts warm season convective initiation in East-Central Florida. The project also examined the use of one- and two-way nesting in predicting warm season convection.

Extended Statistical Short-Range Guidance for Peak Wind Speed Analyses at the Shuttle Landing Facility: Phase II Results

NASA Technical Reports Server (NTRS)

Lambert, Winifred C.

2003-01-01

This report describes the results from Phase II of the AMU's Short-Range Statistical Forecasting task for peak winds at the Shuttle Landing Facility (SLF). The peak wind speeds are an important forecast element for the Space Shuttle and Expendable Launch Vehicle programs. The 45th Weather Squadron and the Spaceflight Meteorology Group indicate that peak winds are challenging to forecast. The Applied Meteorology Unit was tasked to develop tools that aid in short-range forecasts of peak winds at tower sites of operational interest. A seven year record of wind tower data was used in the analysis. Hourly and directional climatologies by tower and month were developed to determine the seasonal behavior of the average and peak winds. Probability density functions (PDF) of peak wind speed were calculated to determine the distribution of peak speed with average speed. These provide forecasters with a means of determining the probability of meeting or exceeding a certain peak wind given an observed or forecast average speed. A PC-based Graphical User Interface (GUI) tool was created to display the data quickly.

Antimicrobial Resistance: Its Surveillance, Impact, and Alternative Management Strategies in Dairy Animals

PubMed Central

Sharma, Chetan; Rokana, Namita; Chandra, Mudit; Singh, Brij Pal; Gulhane, Rohini Devidas; Gill, Jatinder Paul Singh; Ray, Pallab; Puniya, Anil Kumar; Panwar, Harsh

2018-01-01

Antimicrobial resistance (AMR), one among the most common priority areas identified by both national and international agencies, is mushrooming as a silent pandemic. The advancement in public health care through introduction of antibiotics against infectious agents is now being threatened by global development of multidrug-resistant strains. These strains are product of both continuous evolution and un-checked antimicrobial usage (AMU). Though antibiotic application in livestock has largely contributed toward health and productivity, it has also played significant role in evolution of resistant strains. Although, a significant emphasis has been given to AMR in humans, trends in animals, on other hand, are not much emphasized. Dairy farming involves surplus use of antibiotics as prophylactic and growth promoting agents. This non-therapeutic application of antibiotics, their dosage, and withdrawal period needs to be re-evaluated and rationally defined. A dairy animal also poses a serious risk of transmission of resistant strains to humans and environment. Outlining the scope of the problem is necessary for formulating and monitoring an active response to AMR. Effective and commendably connected surveillance programs at multidisciplinary level can contribute to better understand and minimize the emergence of resistance. Besides, it requires a renewed emphasis on investments into research for finding alternate, safe, cost effective, and innovative strategies, parallel to discovery of new antibiotics. Nevertheless, numerous direct or indirect novel approaches based on host–microbial interaction and molecular mechanisms of pathogens are also being developed and corroborated by researchers to combat the threat of resistance. This review places a concerted effort to club the current outline of AMU and AMR in dairy animals; ongoing global surveillance and monitoring programs; its impact at animal human interface; and strategies for combating resistance with an extensive overview on possible alternates to current day antibiotics that could be implemented in livestock sector. PMID:29359135

Antimicrobial Resistance: Its Surveillance, Impact, and Alternative Management Strategies in Dairy Animals.

PubMed

Sharma, Chetan; Rokana, Namita; Chandra, Mudit; Singh, Brij Pal; Gulhane, Rohini Devidas; Gill, Jatinder Paul Singh; Ray, Pallab; Puniya, Anil Kumar; Panwar, Harsh

2017-01-01

Antimicrobial resistance (AMR), one among the most common priority areas identified by both national and international agencies, is mushrooming as a silent pandemic. The advancement in public health care through introduction of antibiotics against infectious agents is now being threatened by global development of multidrug-resistant strains. These strains are product of both continuous evolution and un-checked antimicrobial usage (AMU). Though antibiotic application in livestock has largely contributed toward health and productivity, it has also played significant role in evolution of resistant strains. Although, a significant emphasis has been given to AMR in humans, trends in animals, on other hand, are not much emphasized. Dairy farming involves surplus use of antibiotics as prophylactic and growth promoting agents. This non-therapeutic application of antibiotics, their dosage, and withdrawal period needs to be re-evaluated and rationally defined. A dairy animal also poses a serious risk of transmission of resistant strains to humans and environment. Outlining the scope of the problem is necessary for formulating and monitoring an active response to AMR. Effective and commendably connected surveillance programs at multidisciplinary level can contribute to better understand and minimize the emergence of resistance. Besides, it requires a renewed emphasis on investments into research for finding alternate, safe, cost effective, and innovative strategies, parallel to discovery of new antibiotics. Nevertheless, numerous direct or indirect novel approaches based on host-microbial interaction and molecular mechanisms of pathogens are also being developed and corroborated by researchers to combat the threat of resistance. This review places a concerted effort to club the current outline of AMU and AMR in dairy animals; ongoing global surveillance and monitoring programs; its impact at animal human interface; and strategies for combating resistance with an extensive overview on possible alternates to current day antibiotics that could be implemented in livestock sector.

Elimination of Bisphenol A and Triclosan Using the Enzymatic System of Autochthonous Colombian Forest Fungi

PubMed Central

Arboleda, Carolina; Cabana, H.; De Pril, E.; Jones, J. Peter; Jiménez, G. A.; Mejía, A. I.; Agathos, S. N.; Penninckx, M. J.

2013-01-01

Bisphenol A (BPA) and triclosan (TCS) are known or suspected potential endocrine disrupting chemicals (EDCs) which may pose a risk to human health and have an environmental impact. Enzyme preparations containing mainly laccases, obtained from Ganoderma stipitatum and Lentinus swartzii, two autochthonous Colombian forest white rot fungi (WRF), previously identified as high enzyme producers, were used to remove BPA and TCS from aqueous solutions. A Box-Behnken factorial design showed that pH, temperature, and duration of treatment were significant model terms for the elimination of BPA and TCS. Our results demonstrated that these EDCs were extensively removed from 5 mg L−1 solutions after a contact time of 6 hours. Ninety-four percent of TCS and 97.8% of BPA were removed with the enzyme solution from G. stipitatum; 83.2% of TCS and 88.2% of BPA were removed with the L. swartzii enzyme solution. After a 6-hour treatment with enzymes from G. stipitatum and L. swartzii, up to 90% of the estrogenic activity of BPA was lost, as shown by the yeast estrogen screen assay. 2,2-Azino-bis-(3-ethylthiazoline-6-sulfonate) (ABTS) was used as a mediator (laccase/mediator system) and significantly improved the laccase catalyzed elimination of BPA and TCS. The elimination of BPA in the absence of a mediator resulted in production of oligomers of molecular weights of 454, 680, and 906 amu as determined by mass spectra analysis. The elimination of TCS in the same conditions produced dimers, trimers, and tetramers of molecular weights of 574, 859, and 1146 amu. Ecotoxicological studies using Daphnia pulex to determine lethal concentration (LC50) showed an important reduction of the toxicity of BPA and TCS solutions after enzymatic treatments. Use of laccases emerges thus as a key alternative in the development of innovative wastewater treatment technologies. Moreover, the exploitation of local biodiversity appears as a potentially promising approach for identifying new efficient strains for biotechnological applications. PMID:25969787

USSR Report, International Economic Relations, No. 56.

DTIC Science & Technology

1983-05-18

receive assistance in creating a soil-agrochemical service, a state seed-growing complex, in reconstructing an animal artificial insemination station...for normal business cooperation between the USSR and the USA will remove the artificial obstacles which have been raised in its way. In conclusion I...system in the Jalalabad area, several state ..farms, an oil storage at Hairaton port on the Amu Darya, the .Lotus satellite communication station

SOFIA Science Imagery

NASA Image and Video Library

2017-09-14

SCI2017_0003: The column of material at and just below the surface of dwarf planet Ceres (box) – the top layer contains anhydrous (dry) pyroxene dust accumulated from space mixed in with native hydrous (wet) dust, carbonates, and water ice. (Bottom) Cross section of Ceres showing the surface layers that are the subject of this study plus a watery mantle and a rocky-metallic core. Credit: Pierre Vernazza, LAM–CNRS/AMU

Mass spectrometric measurements of atmospheric composition

NASA Technical Reports Server (NTRS)

Hoffman, J. H.

1974-01-01

The development of a magnetic sector field analyzer for continuous sampling and measurement of outer planetary atmospheres is discussed. Special features of the analyzer include a dynamic range of 10 to the minus 7th power, a mass range from 1 to 48 AMU, two ion sensitivities, a special scan time of 35 sec at 14 BPS, and the use of ion counting techniques for analysis.

Assessing the Use of Remote Sensing and a Crop Growth Model to Improve Modeled Streamflow in Central Asia

NASA Astrophysics Data System (ADS)

Richey, A. S.; Richey, J. E.; Tan, A.; Liu, M.; Adam, J. C.; Sokolov, V.

2015-12-01

Central Asia presents a perfect case study to understand the dynamic, and often conflicting, linkages between food, energy, and water in natural systems. The destruction of the Aral Sea is a well-known environmental disaster, largely driven by increased irrigation demand on the rivers that feed the endorheic sea. Continued reliance on these rivers, the Amu Darya and Syr Darya, often place available water resources at odds between hydropower demands upstream and irrigation requirements downstream. A combination of tools is required to understand these linkages and how they may change in the future as a function of climate change and population growth. In addition, the region is geopolitically complex as the former Soviet basin states develop management strategies to sustainably manage shared resources. This complexity increases the importance of relying upon publically available information sources and tools. Preliminary work has shown potential for the Variable Infiltration Capacity (VIC) model to recreate the natural water balance in the Amu Darya and Syr Darya basins by comparing results to total terrestrial water storage changes observed from NASA's Gravity Recovery and Climate Experiment (GRACE) satellite mission. Modeled streamflow is well correlated to observed streamflow at upstream gauges prior to the large-scale expansion of irrigation and hydropower. However, current modeled results are unable to capture the human influence of water use on downstream flow. This study examines the utility of a crop simulation model, CropSyst, to represent irrigation demand and GRACE to improve modeled streamflow estimates in the Amu Darya and Syr Darya basins. Specifically we determine crop water demand with CropSyst utilizing available data on irrigation schemes and cropping patterns. We determine how this demand can be met either by surface water, modeled by VIC with a reservoir operation scheme, and/or by groundwater derived from GRACE. Finally, we assess how the inclusion of CropSyst and groundwater to model and meet irrigation demand improves modeled streamflow from VIC throughout the basins. The results of this work are integrated into a decision support platform to assist the basin states in understanding water availability and the impact of management decisions on available resources.

Rates and determinants of antimicrobial use, including extra-label, on Ontario sheep farms

PubMed Central

Moon, Catherine S.; Berke, Olaf; Avery, Brent P.; McEwen, Scott A.; Reid-Smith, Richard J.; Scott, Lisa; Menzies, Paula

2011-01-01

Few antimicrobials are licensed for use in sheep in Canada, and the range of indications is narrow. Treatment in an “extra-label” manner may be ineffective. In addition, potentially harmful drug residues in food-animal products and antimicrobial resistance in bacteria may be associated with extra-label drug use (ELDU). No data had been documented on drug use, specifically antimicrobial use (AMU), in Ontario sheep, although it was thought that much use was extra-label. This study investigated AMU and ELDU on 49 lamb-producing Ontario sheep farms. Data were prospectively collected over 12 months from the participating farms, and farm-level practices were ascertained with a questionnaire. Treatment-level and farm-level variables were investigated for associations with rates of AMU by means of Poisson rate regression models fit with a generalized estimating equation to control for clustering at the farm level. Antimicrobials with high mean exposure rates included chlortetracycline (in feed), penicillins, and oxytetracycline. The exposure rate in lambs was significantly lower (P < 0.01) with antimicrobial treatment of systemic signs, respiratory disease, or wound or injury than with treatment of other reported diseases or conditions; it was also significantly lower with 3 or more lambing periods per year (α = 0.05). The exposure rate in adult sheep was significantly lower with treatment of 5 of the 6 most prevalent diseases or conditions (α = 0.05) and significantly higher with producer decision to treat and producer experience of 20 y or greater. Rates of using antimicrobials not licensed for use in sheep were high, as was extra-label use of licensed antimicrobials. Diseases reportedly treated most often with antimicrobials (e.g., systemic signs, mastitis) were significantly associated with lower rates of ELDU (α = 0.05). Compared with the rates in adult sheep, the mean rate of use of nonlicensed antimicrobials was similar in the lambs, whereas the mean rate of extra-label use of licensed antimicrobials was lower among the lambs. The results are useful in determining if public health concerns about antimicrobial use in Ontario sheep are warranted and in creating drug use and licensure strategies for the Canadian sheep industry. PMID:21461189

Managing the water-energy-food nexus: Gains and losses from new water development in Amu Darya River Basin

NASA Astrophysics Data System (ADS)

Jalilov, Shokhrukh-Mirzo; Keskinen, Marko; Varis, Olli; Amer, Saud; Ward, Frank A.

2016-08-01

According to the UN, the population of Central Asia will increase from its current approximately 65 million people to a well over 90 million by the end of this century. Taking this increasing population into consideration, it is impossible to project development strategies without considering three key factors in meeting the demands of a growing population: water, food and energy. Societies will have to choose, for instance, between using land and fertilizer for food production or for bio-based or renewable energy production, and between using fresh water for energy production or for irrigating crops. Thus water, food and energy are inextricably linked and must be considered together as a system. Recently, tensions among the Central Asian countries over the use of water for energy and energy production have increased with the building of Rogun Dam on the Vakhsh River, a tributary of the Amu Darya River. The dam will provide upstream Tajikistan with hydropower, while downstream countries fear it could negatively impact their irrigated agriculture. Despite recent peer reviewed literature on water resources management in Amu Darya Basin, none to date have addressed the interconnection and mutual impacts within water-energy-food systems in face of constructing the Rogun Dam. We examine two potential operation modes of the dam: Energy Mode (ensuring Tajikistan's hydropower needs) and Irrigation Mode (ensuring water for agriculture downstream). Results show that the Energy Mode could ensure more than double Tajikistan's energy capacity, but would reduce water availability during the growing season, resulting in an average 37% decline in agricultural benefits in downstream countries. The Irrigation Mode could bring a surplus in agricultural benefits to Tajikistan and Uzbekistan in addition an increasing energy benefits in Tajikistan by two fold. However, energy production in the Irrigation Mode would be non-optimally distributed over the seasons resulting in the most of hydropower being produced during the growing season. Neither operation mode provides optimal benefits for all the countries, emphasizing how difficult it is to actually reach a win-win scenario across the water-energy-food security nexus in transboundary river basins.

Outgassing of Flown and Unflown MIR Solar Cells

NASA Technical Reports Server (NTRS)

Harvey, Gale A.; Kinard, William H.; Wilson, Linda A.

2000-01-01

A solar panel array with more than ten years space exposure was removed from the Mir core module in November 1997, and an eight panel section was returned to Earth in January 1998. Several solar cells were removed from panel eight of the returned array and placed in a high vacuum system with a residual gas analyzer (200 amu mass spectrometer) and a cold finger. Similar unflown solar cells of the same vintage were later obtained from Energia. Several of the unflown cells were also placed in the vacuum system and outgassed residues were collected on the LN2 cold finger. Almost 3 mg of outgassed residue was collected -from a string of three unflown solar cells over a period of 94 hours under vacuum. The collected residue was weighed with a microbalance, and then the residue was analyzed by FTIR spectroscopy, and by gas chromatograph-mass spectroscopy. About 25 outgassed constituents were separated by the gas chromatograph, and a high-resolution mass spectrum was obtained of each constituent. Molecular identifications have been made for the constituents. The constituents are primarily cyclic siloxanes, and several of the constituents are isomers of the same molecule. Most of the outgassed constituents have a molecular mass of about 500 amu. Almost one mg of residue was extracted from one sq cm of coverglass/adhesive from a flown solar cell by soaking in isopropyl alcohol for 30 minutes. The gas chromatograph separated about 20 constituents. The constituents are mostly cyclic siloxanes with linear branches, hydrocarbons, and phthalates. The typical molecular mass is about 600 amu. These identifications of specific outgassing molecules have resulted in a more complete understanding of the SiO(x) contamination on the Mir solar cell coverglasses, and on the MEEP experiment trays and optical specimens during the Shuttle-Mir Phase One flight experiment program. Adjusted outgassing rates based on the data reported here, and/or measured outgassing rates and specific molecular identifications of ISS hardware samples are needed to input into model predictions of induced environment effects of the ISS.

Dust Storm, Aral Sea

NASA Technical Reports Server (NTRS)

2002-01-01

The Aral Sea has shrunk to less than half its size since 1985. The Aral Sea receives little water (sometimes no water) from the two major rivers that empty into it-the Syr Darya and Amu Darya. Instead, the river water is diverted to support irrigation for the region's extensive cotton fields. Recently, water scarcity has increased due to a prolonged drought in Central Asia. As the Aral Sea recedes, its former sea bed is exposed. The Aral's sea bed is composed of fine sediments-including fertilizers and other agricultural chemicals-that are easily picked up by the region's strong winds, creating thick dust storms. The International Space Station crew observed and recorded a large dust storm blowing eastward from the Aral Sea in late June 2001. This image illustrates the strong coupling between human activities (water diversions and irrigation), and rapidly changing land, sea and atmospheric processes-the winds blow across the

Characterization of recombinant human HBP/CAP37/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes.

PubMed

Rasmussen, P B; Bjørn, S; Hastrup, S; Nielsen, P F; Norris, K; Thim, L; Wiberg, F C; Flodgaard, H

1996-07-15

Neutrophil-derived heparin-binding protein (HBP) is a strong chemoattractant for monocytes. We report here for the first time the expression of recombinant HBP. A baculovirus containing the human HBP cDNA mediated in insect cells the secretion of a 7-residue N-terminally extended HBP form (pro-HBP). Deletion of the pro-peptide-encoding cDNA sequence resulted in correctly processed HBP at the N-terminus. Electrospray mass spectrum analysis of recombinant HBP yielded a molecular weight of 27.237 +/- 3 amu. Consistent with this mass is a HBP form of 225 amino acids (mature part +3 amino acid C-terminal extension). The biological activity of recombinant HBP was confirmed by its chemotactic action towards monocytes. Furthermore, we have shown that recombinant HBP stimulates in a dose-dependent manner the lipopolysaccharide (LPS)-induced cytokine release from human monocytes.

Mycelial actinobacteria in salt-affected soils of arid territories of Ukraine and Russia

NASA Astrophysics Data System (ADS)

Grishko, V. N.; Syshchikova, O. V.; Zenova, G. M.; Kozhevin, P. A.; Dubrova, M. S.; Lubsanova, D. A.; Chernov, I. Yu.

2015-01-01

A high population density (up to hundreds of thousands or millions CFU/g soil) of mycelial bacteria (actinomycetes) is determined in salt-affected soils of arid territories of Ukraine, Russia, and Turkmenistan. Of all the studied soils, the lowest amounts of actinomycetes (thousands and tens of thousands CFU/g soil) are isolated from sor (playa) and soda solonchaks developed on the bottoms of drying salt lakes in Buryatia and in the Amu Darya Delta. Actinomycetes of the Streptomyces, Micromonospora, and Nocardiopsis genera were recorded in the studied soils. It is found that conditions of preincubation greatly affect the activity of substrate consumption by the cultures of actinomycetes. This could be attributed to changes in the metabolism of actinomycetes as a mechanism of their adaptation to the increased osmotic pressure of the medium. The alkali tolerance of halotolerant actinomycetes isolated from the salt-affected soils is experimentally proved.

Analysis of Marine Biota for Chemical Warfare Materials by Means of a Gas Chromatography/Mass Spectrometer System

DTIC Science & Technology

2011-01-01

All of the samples were analyzed in SIM. By comparing the EIC’s (See Appendix) of the MS (for sample EML 091524) and Sample EML091524 it can be...of detection. 25 Blank 26 ACRONYMS amu BFB BME CCV CTC CTF CVAA CVAO CWM DoD ECBC EIC EICP EML EPA GC HD HUMMA IB ICV IOP L

Neutron emission and dose distribution from natural carbon irradiated with a 12 MeV amu-1 12C5+ ion beam.

PubMed

Nandy, Maitreyee; Sarkar, P K; Sanami, T; Takada, M; Shibata, T

2016-09-01

Measured neutron energy distribution emitted from a thick stopping target of natural carbon at 0°, 30°, 60° and 90° from nuclear reactions caused by 12 MeV amu -1 incident 12 C 5+ ions were converted to energy differential and total neutron absorbed dose as well as ambient dose equivalent H * (10) using the fluence-to-dose conversion coefficients provided by the ICRP. Theoretical estimates were obtained using the Monte Carlo nuclear reaction model code PACE and a few existing empirical formulations for comparison. Results from the PACE code showed an underestimation of the high-energy part of energy differential dose distributions at forward angles whereas the empirical formulation by Clapier and Zaidins (1983 Nucl. Instrum. Methods 217 489-94) approximated the energy integrated angular distribution of H * (10) satisfactorily. Using the measured data, the neutron doses received by some vital human organs were estimated for anterior-posterior exposure. The estimated energy-averaged quality factors were found to vary for different organs from about 7 to about 13. Emitted neutrons having energies above 20 MeV were found to contribute about 20% of the total dose at 0° while at 90° the contribution was reduced to about 2%.

MiniSODAR(TradeMark) Evaluation

NASA Technical Reports Server (NTRS)

Short, David A.; Wheeler, Mark M.

2003-01-01

This report describes results of the AMU's Instrumentation and Measurement task for evaluation of the Doppler miniSODAR(TradeMark) System (DmSS). The DmSS is an acoustic wind profiler providing high resolution data to a height of approx. 410 ft. The Boeing Company installed a DmSS near Space Launch Complex 37 in mid-2002 as a substitute for a tall wind tower and plans to use DmSS data for the analysis and forecasting of winds during ground and launch operations. Peak wind speed data are of particular importance to Launch Weather Officers of the 45th Weather Squadron for evaluating user Launch Commit Criteria. The AMU performed a comparative analysis of wind data between the DmSS and nearby wind towers from August 2002 to July 2003. The DmSS vertical profile of average wind speed showed good agreement with the wind towers. However, the DMSS peak wind speeds were higher, on average, than the wind tower peak wind speeds by about 25%. A statistical model of an idealized Doppler profiler was developed and it predicted that average wind speeds would be well determined but peak wind speeds would be over-estimated due to an under-specification of vertical velocity variations in the atmosphere over the Profiler.

Thick optical waveguides in lithium niobate induced by swift heavy ions (approximately 10 MeV/amu) at ultralow fluences.

PubMed

Olivares, José; Crespillo, Miguel L; Caballero-Calero, Olga; Ynsa, María D; García-Cabañes, Angel; Toulemonde, Marcel; Trautmann, Christina; Agulló-López, Fernando

2009-12-21

Heavy mass ions, Kr and Xe, having energies in the approximately 10 MeV/amu range have been used to produce thick planar optical waveguides at the surface of lithium niobate (LiNbO3). The waveguides have a thickness of 40-50 micrometers, depending on ion energy and fluence, smooth profiles and refractive index jumps up to 0.04 (lambda = 633 nm). They propagate ordinary and extraordinary modes with low losses keeping a high nonlinear optical response (SHG) that makes them useful for many applications. Complementary RBS/C data provide consistent values for the partial amorphization and refractive index change at the surface. The proposed method is based on ion-induced damage caused by electronic excitation and essentially differs from the usual implantation technique using light ions (H and He) of MeV energies. It implies the generation of a buried low-index layer (acting as optical barrier), made up of amorphous nanotracks embedded into the crystalline lithium niobate crystal. An effective dielectric medium approach is developed to describe the index profiles of the waveguides. This first test demonstration could be extended to other crystalline materials and could be of great usefulness for mid-infrared applications.

Xenon Fractionation and Archean Hydrogen Escape

NASA Technical Reports Server (NTRS)

Zahnle, K. J.

2015-01-01

Xenon is the heaviest gas found in significant quantities in natural planetary atmospheres. It would seem the least likely to escape. Yet there is more evidence for xenon escape from Earth than for any element other than helium and perhaps neon. The most straightforward evidence is that most of the radiogenic Xe from the decay of (129)I (half-life 15.7 Myr) and (244)Pu (half-life 81 Myr) that is Earth's birthright is missing. The missing xenon is often attributed to the impact erosion of early atmospheres of Earth and its ancestors. It is obvious that if most of the radiogenic xenon were driven off by impacts, most of the rest of the atmophiles fared the same fate. The other line of evidence is in the nonradiogenic isotopes of xenon and its silent partner, krypton. Atmospheric xenon is strongly mass fractionated (at about 4% per amu) compared to any known solar system source (Figure 1). This is in stark contrast to krypton, which may not be fractionated at all: atmospheric Kr is slightly heavier than solar Kr (at about 0.5% per amu), but it is the same as in carbonaceous chondrites. Nonradiogenic xenon is also under abundant relative to krypton (the so-called "missing xenon" problem). Together these observations imply that xenon has been subject to fractionating escape and krypton not.

Giotto IMS measurements of the production rate of hydrogen cyanide in the coma of Comet Halley

NASA Technical Reports Server (NTRS)

Ip, W.-H.; Balsiger, H.; Geiss, J.; Goldstein, B. E.; Kettmann, G.

1990-01-01

The ion composition measurements in the ionosphere of Comet Halley by the ion mass spectrometer (IMS) experiment on the Giotto spacecraft are used to estimate the relative abundance of HCN. From a comparison of the normalized number density of ions with mass-to-charge (M/q) ratio of 28 AMU/e with steady-state photochemical models, it can be determined that the production rate of HCN directly from the central nucleus is Q(HCN) is less than about 0.0002 Q(H2O) at the time of Giotto encounter. The related photochemical- model calculations also indicate that Q(NH3)/Q(H2O) at the time of Giotto encounter. The related photo-chemical model calculations also indicate that Q(HN3)/Q(H2O) equals about 0.005, in agreement with recent determination from ground-based observations. The estimated value of Q(HCN) is lower than the relative abundance of Q(HCN)/Q(H2O) of about 0.001, as derived from radio observations of the 88.6 GHz emission of the J = 1 - 0 transition of HCN. The difference may be the result of time variations of the coma composition and dynamics, as well as other model-dependent effects.

Direct electron-pair production by high energy heavy charged particles

NASA Technical Reports Server (NTRS)

Takahashi, Y.; Gregory, J. C.; Hayashi, T.; Dong, B. L.

1989-01-01

Direct electron pain production via virtual photons by moving charged particles is a unique electro-magnetic process having a substantial dependence on energy. Most electro-magnetic processes, including transition radiation, cease to be sensitive to the incident energy above 10 TeV/AMU. Thus, it is expected, that upon establishment of cross section and detection efficiency of this process, it may provide a new energy measuring technique above 10 TeV/AMU. Three accelerator exposures of emulsion chambers designed for measurements of direct electron-pains were performed. The objectives of the investigation were to provide the fundamental cross-section data in emulsion stacks to find the best-fit theoretical model, and to provide a calibration of measurements of direct electron-pairs in emulsion chamber configurations. This paper reports the design of the emulsion chambers, accelerator experiments, microscope measurements, and related considerations for future improvements of the measurements, and for possible applications to high energy cosmic ray experiments. Also discussed are the results from scanning 56m of emulsion tracks at 1200x magnification so that scanning efficiency is optimized. Measurements of the delta-ray range spectrum were also performed for much shorter track lengths, but with sufficiently large statistics in the number of measured delta-rays.

Composition and chemistry of Titan's thermosphere and ionosphere.

PubMed

Vuitton, V; Yelle, R V; Lavvas, P

2009-02-28

Titan has long been known to harbour the richest atmospheric chemistry in the Solar System. Until recently, it had been believed that complex hydrocarbons and nitriles were produced through neutral chemistry that would eventually lead to the formation of micrometre sized organic aerosols. However, recent measurements by the Cassini spacecraft are drastically changing our understanding of Titan's chemistry. The Ion and Neutral Mass Spectrometer (INMS) and the Cassini Plasma Spectrometer (CAPS) revealed an extraordinary complex ionospheric composition. INMS detected roughly 50 positive ions with m/z<100 and a density higher than 0.1cm-3. CAPS provided evidence for heavy (up to 350amu) positively and negatively charged (up to 4000amu) ions. These observations all indicate that Titan's ionospheric chemistry is incredibly complex and that molecular growth starts in the upper atmosphere rather than at lower altitude. Here, we review the recent progress made on ionospheric chemistry. The presence of heavy neutrals in the upper atmosphere has been inferred as a direct consequence of the presence of complex positive ions. Benzene (C6H6) is created by ion chemistry at high altitudes and its main photolysis product, the phenyl radical (C6H5), is at the origin of the formation of aromatic species at lower altitude.

Late skin damage in rabbits and monkeys after exposure to particulate radiations

NASA Astrophysics Data System (ADS)

Bergtold, D. S.; Cox, A. B.; Lett, J. T.; Su, C. M.

Skin biopsies were taken from the central regions of the ears of New Zealand white rabbits following localized exposure of one ear of each rabbit to 530 MeV/amu Ar or 365 MeV/amu Ne ions. The unirradiated ears served as controls. Biopsies were taken also from the chests and inner thighs of rhesus monkeys after whole-body exposure to 32 MeV protons and from unirradiated control animals. The linear energy transfers (LET∞'s) for the radiations were 90 +/- 5, 35 +/- 3, and ~1.2 keV/μm, respectively. In the rabbit studies, explants were removed with a 2 mm diameter dermal punch at post-irradiation times up to five years after exposure. Similar volumes of monkey tissue were taken from skin samples excised surgically 16-18 years following proton irradiation. Fibroblast cultures were initiated from the explants and were propagated in vitro until terminal senescence (cessation of cell division) occurred. Cultures from irradiated tissue exhibited decreases in doubling potential that were dependent on radiation dose and LET∞ and seemed to reflect damage to stem cell populations. The implications of these results for astronauts exposed to heavy ions and/or protons in space include possible manifestations of residual effects in the skin many years after exposure (e.g. unsatisfactory responses to trauma or surgery).

Evaluation of Mesoscale Model Phenomenological Verification Techniques

NASA Technical Reports Server (NTRS)

Lambert, Winifred

2006-01-01

Forecasters at the Spaceflight Meteorology Group, 45th Weather Squadron, and National Weather Service in Melbourne, FL use mesoscale numerical weather prediction model output in creating their operational forecasts. These models aid in forecasting weather phenomena that could compromise the safety of launch, landing, and daily ground operations and must produce reasonable weather forecasts in order for their output to be useful in operations. Considering the importance of model forecasts to operations, their accuracy in forecasting critical weather phenomena must be verified to determine their usefulness. The currently-used traditional verification techniques involve an objective point-by-point comparison of model output and observations valid at the same time and location. The resulting statistics can unfairly penalize high-resolution models that make realistic forecasts of a certain phenomena, but are offset from the observations in small time and/or space increments. Manual subjective verification can provide a more valid representation of model performance, but is time-consuming and prone to personal biases. An objective technique that verifies specific meteorological phenomena, much in the way a human would in a subjective evaluation, would likely produce a more realistic assessment of model performance. Such techniques are being developed in the research community. The Applied Meteorology Unit (AMU) was tasked to conduct a literature search to identify phenomenological verification techniques being developed, determine if any are ready to use operationally, and outline the steps needed to implement any operationally-ready techniques into the Advanced Weather Information Processing System (AWIPS). The AMU conducted a search of all literature on the topic of phenomenological-based mesoscale model verification techniques and found 10 different techniques in various stages of development. Six of the techniques were developed to verify precipitation forecasts, one to verify sea breeze forecasts, and three were capable of verifying several phenomena. The AMU also determined the feasibility of transitioning each technique into operations and rated the operational capability of each technique on a subjective 1-10 scale: (1) 1 indicates that the technique is only in the initial stages of development, (2) 2-5 indicates that the technique is still undergoing modifications and is not ready for operations, (3) 6-8 indicates a higher probability of integrating the technique into AWIPS with code modifications, and (4) 9-10 indicates that the technique was created for AWIPS and is ready for implementation. Eight of the techniques were assigned a rating of 5 or below. The other two received ratings of 6 and 7, and none of the techniques a rating of 9-10. At the current time, there are no phenomenological model verification techniques ready for operational use. However, several of the techniques described in this report may become viable techniques in the future and should be monitored for updates in the literature. The desire to use a phenomenological verification technique is widespread in the modeling community, and it is likely that other techniques besides those described herein are being developed, but the work has not yet been published. Therefore, the AMIU recommends that the literature continue to be monitored for updates to the techniques described in this report and for new techniques being developed whose results have not yet been published. 111

Using Flow Regime Lightning and Sounding Climatologies to Initialize Gridded Lightning Threat Forecasts for East Central Florida

NASA Technical Reports Server (NTRS)

Lambert, Winifred; Short, David; Wolkmer, Matthew; Sharp, David; Spratt, Scott

2006-01-01

Each morning, the forecasters at the National Weather Service in Melbourne, FL (NWS MLB) produce an experimental cloud-to-ground (CG) lightning threat index map for their county warning area (CWA) that is posted to their web site (http://www.srh.weather.gov/mlb/ghwo/lightning.shtml) . Given the hazardous nature of lightning in East Central Florida, especially during the warm season months of May September, these maps help users factor the threat of lightning, relative to their location, into their daily plans. The maps are color-coded in five levels from Very Low to Extreme, with threat level definitions based on the probability of lightning occurrence and the expected amount of CG activity. On a day in which thunderstorms are expected, there are typically two or more threat levels depicted spatially across the CWA. The locations of relative lightning threat maxima and minima often depend on the position and orientation of the low-level ridge axis, forecast propagation and interaction of sea/lake/outflow boundaries, expected evolution of moisture and stability fields, and other factors that can influence the spatial distribution of thunderstorms over the CWA. The lightning threat index maps are issued for the 24-hour period beginning at 1200 UTC each day with a grid resolution of 5 km x 5 km. Product preparation is performed on the AWIPS Graphical Forecast Editor (GFE), which is the standard NWS platform for graphical editing. Currently, the forecasters create each map manually, starting with a blank map. To improve efficiency of the forecast process, NWS MLB requested that the Applied Meteorology Unit (AMU) create gridded warm season lightning climatologies that could be used as first-guess inputs to initialize lightning threat index maps. The gridded values requested included CG strike densities and frequency of occurrence stratified by synoptic-scale flow regime. The intent is to improve consistency between forecasters while allowing them to focus on the mesoscale detail of the forecast, ultimately benefiting the end-users of the product. Several studies took place at the Florida State University (FSU) and NWS Tallahassee (TAE) in which they created daily flow regimes using Florida 1200 UTC synoptic soundings and CG strike densities, or number of strikes per specified area. The soundings used to determine the flow regimes were taken at Miami (MIA), Tampa (TBW), and Jacksonville (JAX), FL, and the lightning data for the strike densities came from the National Lightning Detection Network (NLDN). The densities were created on a 2.5 km x 2.5 km grid for every hour of every day during the warm seasons in the years 1989-2004. The grids encompass an area that includes the entire state of Florida and adjacent Atlantic and Gulf of Mexico waters. Personnel at FSU and NWS TAE provided this data and supporting software for the work performed by the AMU.

Using Flow Regime Lightning and Sounding Climatologies to Initialize Gridded Lightning Threat Forecasts for East Central Florida

NASA Technical Reports Server (NTRS)

Lambert, Winifred; Short, David; Volkmer, Matthew; Sharp, David; Spratt, Scott

2007-01-01

Each morning, the forecasters at the National Weather Service in Melbourne, FL (NWS MLB) produce an experimental cloud-to-ground (CG) lightning threat index map for their county warning area (CWA) that is posted to their web site (httl://www.srh.weather.gov/mlb/ghwo/lightning.shtml) . Given the hazardous nature of lightning in East Central Florida, especially during the warm season months of May September, these maps help users factor the threat of lightning, relative to their location, into their daily plans. The maps are color-coded in five levels from Very Low to Extreme, with threat level definitions based on the probability of lightning occurrence and the expected amount of CG activity. On a day in which thunderstorms are expected, there are typically two or more threat levels depicted spatially across the CWA. The locations of relative lightning threat maxima and minima often depend on the position and orientation of the low-level ridge axis, forecast propagation and interaction of sea/lake/outflow boundaries, expected evolution of moisture and stability fields, and other factors that can influence the spatial distribution of thunderstorms over the CWA. The lightning threat index maps are issued for the 24-hour period beginning at 1200 UTC each day with a grid resolution of 5 km x 5 km. Product preparation is performed on the AWIPS Graphical Forecast Editor (GFE), which is the standard NWS platform for graphical editing. Until recently, the forecasters created each map manually, starting with a blank map. To improve efficiency of the forecast process, NWS MLB requested that the Applied Meteorology Unit (AMU) create gridded warm season lightning climatologies that could be used as first-guess inputs to initialize lightning threat index maps. The gridded values requested included CG strike densities and frequency of occurrence stratified by synoptic-scale flow regime. The intent was to improve consistency between forecasters while allowing them to focus on the mesoscale detail of the forecast. Several studies took place at the Florida State University (FSU) and NWS Tallahassee (TAE) in which they created daily flow regimes using Florida 1200 UTC synoptic soundings and CG strike densities, or number of strikes per specified area. The soundings used to determine the flow regimes were taken at Miami (MIA), Tampa (TBW), and Jacksonville (JAX), FL, and the lightning data for the strike densities came from the National Lightning Detection Network (NLDN). The densities were created on a 2.5 km x 2.5 km grid for every hour of every day during the warm seasons in the years 1989-2004. The grids encompass an area that includes the entire state of Florida and adjacent Atlantic and Gulf of Mexico waters. Personnel at FSU and NWS TAE provided this data and supporting software for the work performed by the AMU.

A statistical survey of ultralow-frequency wave power and polarization in the Hermean magnetosphere.

PubMed

James, Matthew K; Bunce, Emma J; Yeoman, Timothy K; Imber, Suzanne M; Korth, Haje

2016-09-01

We present a statistical survey of ultralow-frequency wave activity within the Hermean magnetosphere using the entire MErcury Surface, Space ENvironment, GEochemistry, and Ranging magnetometer data set. This study is focused upon wave activity with frequencies <0.5 Hz, typically below local ion gyrofrequencies, in order to determine if field line resonances similar to those observed in the terrestrial magnetosphere may be present. Wave activity is mapped to the magnetic equatorial plane of the magnetosphere and to magnetic latitude and local times on Mercury using the KT14 magnetic field model. Wave power mapped to the planetary surface indicates the average location of the polar cap boundary. Compressional wave power is dominant throughout most of the magnetosphere, while azimuthal wave power close to the dayside magnetopause provides evidence that interactions between the magnetosheath and the magnetopause such as the Kelvin-Helmholtz instability may be driving wave activity. Further evidence of this is found in the average wave polarization: left-handed polarized waves dominate the dawnside magnetosphere, while right-handed polarized waves dominate the duskside. A possible field line resonance event is also presented, where a time-of-flight calculation is used to provide an estimated local plasma mass density of ∼240 amu cm -3 .

Hydrochemical water evolution in the Aral Sea Basin. Part I: Unconfined groundwater of the Amu Darya Delta - Interactions with surface waters

NASA Astrophysics Data System (ADS)

Schettler, Georg; Oberhänsli, Hedi; Stulina, Galina; Mavlonov, Aslon A.; Naumann, Rudolf

2013-07-01

The Aral Sea, which has been affected by lake level lowering of approximately 25 m and a salinity increase from 10 to >100 g/l since 1963, represents, along with the Amu Dary Delta a dynamic hydrological system under an arid climate regime. The system receives river water inflow at high seasonal and inter-annual variability from remote alpine source areas. In the Amu Darya Delta, there is a distinct salinity contrast between the low-salinity river water (∼1 g/l) and the salinity of the unconfined GW (GWunconf: 10-95 g/l). The GWunconf levels are predominantly controlled by the seepage of the river water inflow and GW discharge into the shrinking Aral Sea. In June 2009 and August 2009, we sampled water from various sources including surface waters, GWunconf, lake water and soil leachates for chemical analyses. Evaporative enrichment, precipitation/dissolution of gypsum and precipitation of calcite drive the GWunconf to an NaCl(SO4) water type presenting a positive correlation between Na and SO4. We model the hydrochemical evolution of the GWunconf in a box model which considers the capillary rise of near-surface GW, the precipitation of minerals in the unsaturated horizon and the seasonal re-flushing of adhesive residual brines and soluble salts. The model documents a rapid increase in salinity over a few annual cycles. Furthermore, the model simulations demonstrate the importance of the aeolian redistribution of soluble salts on the hydrochemical GW evolution. In a lab experiment, halite, hexahydrite and starkeyite are precipitated during the late stages of evaporative enrichment from a representative local brine. Processes specific to different water compartments plausibly explain the variations of selected element ratios. For example, the precipitation of low-Sr calcite in irrigation canals and natural river branches of the delta lowers Ca/Sr. The dissolution of gypsum in soils (Ca/Sr mole ratio ∼ 150) and the possible precipitation of SrSO4 associated with Sr-depletion in adhesive residual brines increases Ca/Sr in seepage and re-increases Ca/Sr in the unconfined GW. Aral Sea water, which receives high-Ca/Sr surface and groundwater inflow, developed due to continued precipitation of high-Ca/Sr calcite the almost lowest Ca/Sr ratio (∼25) over time. We observed spatial variations in the GWunconf composition: (i) ammonium levels increase strongly due to interaction with lake sediments rich in organic matter and (ii) distinct increases in levels of nitrate, U, Mo and Se locally reflect oxygenation when GW levels decrease. The Amu Darya Delta acts as a sink for boron (uptake via terrestrial vegetation) and a source for bromide (release by degradation of organically-bound Br). Our results concerning the hydrochemical evolution of the GWunconf and additional data from the Aral Sea constrain the parameter ‘GW discharge’ in water budget models of the lake and improve the basis for palaeoclimatic interpretations of sediment records from the Aral Sea.

Aral Sea in Uzbekastan seen from STS-59

NASA Technical Reports Server (NTRS)

1994-01-01

View northeastward across Uzbekastan to the partly-ice-covered Aral Sea and Kazakhstan. The irrigated fan-delta of the Amu Darya extends from the right side of the photograph to end in extensive salt flats at the south end of the sea. The Aral was the fourth-largest inland sea or lake in the world, until diversion and over-use of the river water for irrigation led, in this arid climate, to the sea's decline.

Stopping of 200-GeV gold nuclei in nuclear emulsions

NASA Technical Reports Server (NTRS)

Waddington, C.J.; Freier, P. S.; Fixsen, D. J.

1983-01-01

The residual ranges of Au-197(79) nuclei stopping in nuclear emulsions has been measured for nuclei with an incident energy of 991 MeV/amu. The mean ranges observed are appreciably less than those predicted from measurements made on energetic particles of lower charge. However, by the consideration of higher-order correction terms to the rate of energy loss, good agreement can be obtained between the predicted and observed ranges.

Neon transport in selected organic composites. [stopping power of Kapton and polyethylene

NASA Technical Reports Server (NTRS)

Townsend, L. W.; Wilson, J. W.; Bidasaria, H. B.

1984-01-01

An energy-dependent, perturbation expansion solution for heavy-ion transport in one dimension was used to calculate the dose from Ne-20 beams at incident kinetic energies of 350, 670, and 2000 MeV/amu onto selected organic composites. Transport coefficients, applicable to arbitrary ion beams over a broad range of energies, are presented. Polyethylene and Kapton were tested as constituents of multilayered shielding for spacecraft and astronauts.

Design and fabrication of a basic mass analyzer and vacuum system

NASA Technical Reports Server (NTRS)

Judson, C. M.; Josias, C.; Lawrence, J. L., Jr.

1977-01-01

A two-inch hyperbolic rod quadrupole mass analyzer with a mass range of 400 to 200 amu and a sensitivity exceeding 100 packs per billion has been developed and tested. This analyzer is the basic hardware portion of a microprocessor-controlled quadrupole mass spectrometer for a Gas Analysis and Detection System (GADS). The development and testing of the hyperbolic-rod quadrupole mass spectrometer and associated hardware are described in detail.

Detection of Dichlorvos Adducts in a Hepatocyte Cell Line

DTIC Science & Technology

2014-06-30

form adducts to DDVP.16,20−22 Two distinct DDVP adducts are formed by covalent bonding to the hydroxyl group of tyrosine, serine, and threonine ...variable modifications on methionine (oxidation) and on serine, tyrosine, or threonine (phosphorylation, O-methylphosphate, or O-dimethylphosphate). Only...modifications on tyrosine, serine, or threonine residues with a mass of 94 or 108 amu corresponding to O-methyl- or O-dimethyl-phosphate groups. We found 53

Effect of giant charge-transfer resonance σCT 109 barn on operation of magnetic fusion reactor below ``critical energy.''

NASA Astrophysics Data System (ADS)

Hester, Timothy; Maglich, Bogdan; Scott, Dan; Vaucher, Alexander

2016-10-01

Charge transfer (CT) reactivity was assumed to be negligible compared to ionization (IO) before Belfast measurements1-3 revealed the opposite: CT predominance over IO, σCT 109 b , σCT /σIO U 100 , below critical `atomic unit of velocity', vo = 2.2 ×108cms-1 , which is orbital velocity of e in H atom. Near vo, U = 1 , i.e. σCT σIO . Critical ion energy is T0 (lab) = k 25 M [ KeV ] = 200 KeV for [ ERR : md : MbegChr = 0 x 2329 , MendChr = 0 x 232 A , nParams = 1 ] = ion mass [ amu ] = 4 for DT mix ; k = 2 . ``Burnout'' pumping that requires U << 1 is inoperable in the U >> 1 regime whereas CT continually acts like compressor increasing operating vacuum pressure during neutral beam discharge to 10-3 Torr/0.3 s; this, in turn, sets upper limits to ion life-time against neutralization to τ =10-6 s. τ is 105 times shorter than thermalization time constant; hence plasma cannot be created. Lawson4 was unaware of CT resonance; his ``critical temperature'' (30 KeV for DT) should be replaced with T0.

Objective Lightning Probability Forecasting for Kennedy Space Center and Cape Canaveral Air Force Station, Phase II

NASA Technical Reports Server (NTRS)

Lambert, Winifred; Wheeler, Mark

2007-01-01

This report describes the work done by the Applied Meteorology Unit (AMU) to update the lightning probability forecast equations developed in Phase I. In the time since the Phase I equations were developed, new ideas regarding certain predictors were formulated and a desire to make the tool more automated was expressed by 45 WS forecasters. Five modifications were made to the data: 1) increased the period of record from 15 to 17 years, 2) modified the valid area to match the lighting warning areas, 3) added the 1000 UTC CCAFS sounding to the other soundings in determining the flow regime, 4) used a different smoothing function for the daily climatology, and 5) determined the optimal relative humidity (RH) layer to use as a predictor. The new equations outperformed the Phase I equations in several tests, and improved the skill of the forecast over the Phase I equations by 8%. A graphical user interface (GUI) was created in the Meteorological Interactive Data Display System (MIDDS) that gathers the predictor values for the equations automatically. The GUI was transitioned to operations in May 2007 for the 2007 warm season.

An Objective Verification of the North American Mesoscale Model for Kennedy Space Center and Cape Canaveral Air Force Station

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2010-01-01

The 45th Weather Squadron (45 WS) Launch Weather Officers (LWO's) use the 12-km resolution North American Mesoscale (NAM) model (MesoNAM) text and graphical product forecasts extensively to support launch weather operations. However, the actual performance of the model at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) has not been measured objectively. In order to have tangible evidence of model performance, the 45 WS tasked the Applied Meteorology Unit (AMU; Bauman et ai, 2004) to conduct a detailed statistical analysis of model output compared to observed values. The model products are provided to the 45 WS by ACTA, Inc. and include hourly forecasts from 0 to 84 hours based on model initialization times of 00, 06, 12 and 18 UTC. The objective analysis compared the MesoNAM forecast winds, temperature (T) and dew pOint (T d), as well as the changes in these parameters over time, to the observed values from the sensors in the KSC/CCAFS wind tower network shown in Table 1. These objective statistics give the forecasters knowledge of the model's strengths and weaknesses, which will result in improved forecasts for operations.

Maintaining a Local Data Integration System in Support of Weather Forecast Operations

NASA Technical Reports Server (NTRS)

Watson, Leela R.; Blottman, Peter F.; Sharp, David W.; Hoeth, Brian

2010-01-01

Since 2000, both the National Weather Service in Melbourne, FL (NWS MLB) and the Spaceflight Meteorology Group (SMG) at Johnson Space Center in Houston, TX have used a local data integration system (LDIS) as part of their forecast and warning operations. The original LDIS was developed by NASA's Applied Meteorology Unit (AMU; Bauman et ai, 2004) in 1998 (Manobianco and Case 1998) and has undergone subsequent improvements. Each has benefited from three-dimensional (3-D) analyses that are delivered to forecasters every 15 minutes across the peninsula of Florida. The intent is to generate products that enhance short-range weather forecasts issued in support of NWS MLB and SMG operational requirements within East Central Florida. The current LDIS uses the Advanced Regional Prediction System (ARPS) Data Analysis System (ADAS) package as its core, which integrates a wide variety of national, regional, and local observational data sets. It assimilates all available real-time data within its domain and is run at a finer spatial and temporal resolution than current national- or regional-scale analysis packages. As such, it provides local forecasters with a more comprehensive understanding of evolving fine-scale weather features

Delta 2 Explosion Plume Analysis Report

NASA Technical Reports Server (NTRS)

Evans, Randolph J.

2000-01-01

A Delta II rocket exploded seconds after liftoff from Cape Canaveral Air Force Station (CCAFS) on 17 January 1997. The cloud produced by the explosion provided an opportunity to evaluate the models which are used to track potentially toxic dispersing plumes and clouds at CCAFS. The primary goal of this project was to conduct a case study of the dispersing cloud and the models used to predict the dispersion resulting from the explosion. The case study was conducted by comparing mesoscale and dispersion model results with available meteorological and plume observations. This study was funded by KSC under Applied Meteorology Unit (AMU) option hours. The models used in the study are part of the Eastern Range Dispersion Assessment System (ERDAS) and include the Regional Atmospheric Modeling System (RAMS), HYbrid Particle And Concentration Transport (HYPACT), and Rocket Exhaust Effluent Dispersion Model (REEDM). The primary observations used for explosion cloud verification of the study were from the National Weather Service's Weather Surveillance Radar 1988-Doppler (WSR-88D). Radar reflectivity measurements of the resulting cloud provided good estimates of the location and dimensions of the cloud over a four-hour period after the explosion. The results indicated that RAMS and HYPACT models performed reasonably well. Future upgrades to ERDAS are recommended.

The Influence of Non-spectral Matrix Effects on the Accuracy of Isotope Ratio Measurement by MC-ICP-MS

NASA Astrophysics Data System (ADS)

Barling, J.; Shiel, A.; Weis, D.

2006-12-01

Non-spectral interferences in ICP-MS are caused by matrix elements effecting the ionisation and transmission of analyte elements. They are difficult to identify in MC-ICP-MS isotopic data because affected analyses exhibit normal mass dependent isotope fractionation. We have therefore investigated a wide range of matrix elements for both stable and radiogenic isotope systems using a Nu Plasma MC-ICP-MS. Matrix elements commonly enhance analyte sensitivity and change the instrumental mass bias experienced by analyte elements. These responses vary with element and therefore have important ramifications for the correction of data for instrumental mass bias by use of an external element (e.g. Pb and many non-traditional stable isotope systems). For Pb isotope measurements (Tl as mass bias element), Mg, Al, Ca, and Fe were investigated as matrix elements. All produced signal enhancement in Pb and Tl. Signal enhancement varied from session to session but for Ca and Al enhancement in Pb was less than for Tl while for Mg and Fe enhancement levels for Pb and Tl were similar. After correction for instrumental mass fractionation using Tl, Mg effected Pb isotope ratios were heavy (e.g. ^{208}Pb/204Pbmatrix > ^{208}Pb/204Pbtrue) for both moderate and high [Mg] while Ca effected Pb showed little change at moderate [Ca] but were light at high [Ca]. ^{208}Pb/204Pbmatrix - ^{208}Pb/204Pbtrue for all elements ranged from +0.0122 to - 0.0177. Isotopic shifts of similar magnitude are observed between Pb analyses of samples that have seen either one or two passes through chemistry (Nobre Silva et al, 2005). The double pass purified aliquots always show better reproducibility. These studies show that the presence of matrix can have a significant effect on the accuracy and reproducibility of replicate Pb isotope analyses. For non-traditional stable isotope systems (e.g. Mo(Zr), Cd(Ag)), the different responses of analyte and mass bias elements to the presence of matrix can result in del/amu for measured & mass bias corrected data that disagree outside of error. Either or both values can be incorrect. For samples, unlike experiments, the correct del/amu is not known in advance. Therefore, for sample analyses to be considered accurate, both measured and exponentially corrected del/amu should agree.

Understanding the formation and composition of hazes in planetary atmospheres that contain carbon monoxide

NASA Astrophysics Data System (ADS)

Hörst, S. M.; Yoon, Y. H.; Hicks, R. K.; Tolbert, M. A.

2012-09-01

Measurements from the Cassini Plasma Spectrometer (CAPS) have revealed the presence of molecules in Titan's ionosphere with masses in excess of hundreds of amu. Negative ions with mass/charge (m/z) up to 10,000 amu/q [1] and positive ions with m/z up to 400 amu/q [2] have been detected. CAPS has also observed O+ flowing into Titan's upper atmosphere [3], which appears to originate from Enceladus and is likely the source of oxygen bearing molecules in Titan's atmosphere [4]. The observed O+ is deposited in the region now known to contain large organic molecules. A recent Titan atmosphere simulation experiment has shown that incorporation of oxygen into Titan aerosol analogues results in the formation of all five nucleotide bases and the two smallest amino acids, glycine and alanine [5]. Similar chemical processes may have occurred in the atmosphere of the early Earth, or in the atmospheres of extrasolar planets; atmospheric aerosols may be an important source of the building blocks of life. Atmospheric aerosols play an important role in determining the radiation budget of an atmosphere and can also provide a wealth of organic material to the surface. The presence of atmospheric aerosols has been invoked to explain the relatively featureless spectrum of HD 189773b, including the lack of predicted atmospheric Na and K spectral lines [9]. The majority of the O+ precipitating into Titan's atmosphere forms CO (O(3P)+CH3 -> CO+H2+H) [4]. CO has also been detected in the atmospheres of a number of exoplanets including HD 189733b, HD 209458b, and WASP-12b [6-8]. It is therefore important to understand the role CO plays in the formation and composition of hazes in planetary atmospheres. Using a High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-ToF-AMS) (see e.g. [10]) we have obtained in situ composition measurements of aerosol particles (so-called "tholins") produced in N2/CH4/CO gas mixtures subjected to either FUV radiation (deuterium lamp, 115-400 nm) or a spark discharge for a range of initial CO mixing ratios. A comparison of the composition of tholins produced using the two different energy sources will be presented. The effect of variation of CO mixing ratio on aerosol production and composition will also be discussed.

Three Dimensional Lightning Launch Commit Criteria Visualization Tool

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2014-01-01

Lightning occurrence too close to a NASA LSP or future SLS program launch vehicle in flight would have disastrous results. The sensitive electronics on the vehicle could be damaged to the point of causing an anomalous flight path and ultimate destruction of the vehicle and payload.According to 45th Weather Squadron (45 WS) Lightning Launch Commit Criteria (LLCC), a vehicle cannot launch if lightning is within 10 NM of its pre-determined flight path. The 45 WS Launch Weather Officers (LWOs) evaluate this LLCC for their launch customers to ensure the safety of the vehicle in flight. Currently, the LWOs conduct a subjective analysis of the distance between lightning and the flight path using data from different display systems. A 3-D display in which the lightning data and flight path are together would greatly reduce the ambiguity in evaluating this LLCC. It would give the LWOs and launch directors more confidence in whether a GO or NO GO for launch should be issued. When lightning appears close to the path, the LWOs likely err on the side of conservatism and deem the lightning to be within 10 NM. This would cause a costly delay or scrub. If the LWOs can determine with a strong level of certainty that the lightning is beyond 10 NM, launch availability would increase without compromising safety of the vehicle, payload or, in the future, astronauts.The AMU was tasked to conduct a market research of commercial, government, and open source software that might be able to ingest and display the 3-D lightning data from the KSC Lightning Mapping Array (LMA), the 45th Space Wing Weather Surveillance Radar (WSR), the National Weather Service in Melbourne Weather Surveillance Radar 1988 Doppler (WSR-88D), and the vehicle flight path data so that all can be visualized together. To accomplish this, the AMU conducted Internet searches for potential software candidates and interviewed software developers.None of the available off-the-shelf software had a 3-D capability that could display all of the data in a single visualization. The AMU determined there are two viable software packages that could satisfy the 45 WS requirement with further development and recommends the KSC Weather Office follow-up with both organizations to request development costs.

An Analysis of the Requirements and Potential Opportunities for the Future Education of Law Enforcement Intelligence Analysts

DTIC Science & Technology

2008-03-01

thinking as a specialized course. None of these schools requires a foreign language. Only Cal State Fullerton and Sacrament State requires students to...research methods. None of the schools require a foreign language. AMU offers critical thinking as an elective from its General Program for students ...analysts should learn more about the religion. Question Six: Instruction in which of these types of philosophies (Western, Eastern, Middle Eastern, or

Design of An Improved Miniature Ion Neutral Mass Spectrometer for NASA Applications

NASA Technical Reports Server (NTRS)

Swaminathan, Viji K.; Alig, Roger C.

1997-01-01

The ion optics of NASA's Ion Neutral Mass Spectrometer (INMS) sensor was simulated with three dimensional models of the open source, the quadrupole deflector, the exit lens system and the quadrupole mass analyzer to design more compact models with lower weight. Comparison of calculated transmission with experimental results shows good agreement. Transmission analyses with varying geometrical parameters and voltages throw light on possible ways of reducing the size of the sensor. Trajectories of ions of mass 1-99 amu were simulated to analyze and optimize transmission. Analysis of open source transmission with varying angle of attack shows that the angular acceptance can be considerably increased by programming the voltages on the ion trap/ collimator. Analysis of transmission sensitivity to voltages and misalignments of the quadrupole deflector rods indicate that increased transmission is possible with a geometrically asymmetrical deflector and a deflector can be designed with much lower sensitivities of transmission. Bringing the disks closer together can decrease the size of the quadrupole deflector and also increase transmission. The exit lens system can be redesigned to be smaller by eliminating at least one electrode entirely without loss of transmission. Ceramic materials were investigated to find suitable candidates for use in the construction of lighter weight mass spectrometer. A high-sensitivity, high-resolution portable gas chromatograph mass spectrometer with a mass range of 2-700 amu has been built and will be commercialized in Phase 3.

Charge-state dependence of binary-encounter-electron cross sections and peak energies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hidmi, H.I.; Richard, P.; Sanders, J.M.

The charge-state dependence of the binary-encounter-electron (BEE) double-differential cross section (DDCS) at 0[degree] with respect to the beam direction resulting from collisions of 1 MeV/amu H[sup +], C[sup [ital q]+], N[sup [ital q]+], O[sup [ital q]+], F[sup [ital q]+], Si[sup [ital q]+], and Cl[sup [ital q]+], and 0.5 MeV/amu Cu[sup [ital q]+] with H[sub 2] is reported. The data show an enhancement in the BEE DDCS as the charge state of the projectile is decreased, in agreement with the data reported by Richard [ital et] [ital al]. [J. Phys. B 23, L213 (1990)]. The DDCS enhancement ratios observed for themore » three-electron isoelectronic sequence C[sup 3+]:C[sup 6+], N[sup 4+]:N[sup 7+], O[sup 5+]:O[sup 8+], and F[sup 6+]:F[sup 9+] are about 1.35, whereas a DDCS enhancement of 3.5 was observed for Cu[sup 4+]. The BEE enhancement with increasing electrons on the projectile has been shown by several authors to be due to the non-Coulomb static potential of the projectile and additionally to the [ital e]-[ital e] exchange interaction. An impulse-approximation (IA) model fits the shape of the BEE DDCS and predicts a [ital Z][sub [ital p

An electrodynamic ion funnel for electrospray ionization source based time-of-flight mass spectrometry

NASA Astrophysics Data System (ADS)

Bhushan, K. G.; Rao, K. C.; Sule, U.; Reddy, P.; Rodrigues, S. M.; Gaikwad, D. T.; Mukundhan, R.; Gupta, S. K.

2016-04-01

An electrodynamic ion funnel has been developed for improving the sensitivity of electrospray ionization sources widely used in the mass spectrometric study of proteins and other biological macromolecules. The ion funnel consists of 52 electrodes and works under the combined influence of RF and DC voltages in the pressure range of 0.1 to 5 mbar. A novel feature of this ion funnel is the specific shape of the exit electrode that improves transmission of lower mass ions by reducing the depth of effective trapping potentials. In this paper, we report on the optimization of the ion funnel design using ion trajectory simulation software SIMION 8.0 especially in the mass range 500-5000 amu, followed by experimental observations of the ion transmission from the electrospray interface. It is seen that the electrospray-ion funnel combination greatly enhances the transmission when compared with an electrospray-skimmer interface. Ion currents > 1 nA could be obtained at the exit of the ion funnel for dilute Streptomycin Sulphate (~ 1500 amu) solution with the ion funnel operating in the 500-900 kHz frequency range, amplitude of 70 Vp-p, under a DC gradient of about 20 Volts/cm at a background pressure of 0.3 mbar. Details of the construction of the ion funnel along with the experimental results are presented.

Distinguishing sympathomimetic amines from amphetamine and methamphetamine in urine by gas chromatography/mass spectrometry.

PubMed

Thurman, E M; Pedersen, M J; Stout, R L; Martin, T

1992-01-01

Derivatives of seven commonly used sympathomimetic amines and two "designer amines" were isolated from urine, separated chromatographically from amphetamine and methamphetamine, and determined by mass spectrometry with selected ion monitoring. The drugs included ephedrine, propylhexedrine, pseudoephedrine, phenylpropanolamine, hydroxynorephedrine, phenylephrine, phentermine, methylenedioxyamphetamine (MDA), and methylenedioxy methamphetamine (MDMA). The drugs were liquid extracted from urine and derivatized by either heptafluorobutyric anhydride (HFBA) or 4-carbethoxyhexafluorobutyryl chloride (4-CB). Because the base peak ions for ephedrine, pseudoephedrine, propylhexedrine, MDMA, and phentermine are identical to methamphetamine (e.g. 254 amu for HFBA) and those for phenylephrine, hydroxynorephedrine, phenylpropanolamine, and MDA are identical to amphetamine (e.g. 240 amu for HFBA), a table of selected ions was developed for all 11 drugs that distinguished amphetamine and methamphetamine from the sympathomimetic amines with either HFBA or 4-CB. The distinguishing ions rely on the ring structure of the different drugs and fragmentation associated with that structure. The 4-CB reagent partially derivatized the hydroxy-containing sympathomimetic amines, while the HFBA completely derivatized all the sympathomimetic amines. Furthermore, false positive results for the 4-CB reagent were found only for methamphetamine (20-2250 ng/mL of methamphetamine) when high concentrations (greater than 5 micrograms) of ephedrine or pseudoephedrine were present in the specimen. These results are related to a combination of injection port temperature and cleanliness of the injection port sleeve.

Real-time single-molecule imaging of quantum interference.

PubMed

Juffmann, Thomas; Milic, Adriana; Müllneritsch, Michael; Asenbaum, Peter; Tsukernik, Alexander; Tüxen, Jens; Mayor, Marcel; Cheshnovsky, Ori; Arndt, Markus

2012-03-25

The observation of interference patterns in double-slit experiments with massive particles is generally regarded as the ultimate demonstration of the quantum nature of these objects. Such matter-wave interference has been observed for electrons, neutrons, atoms and molecules and, in contrast to classical physics, quantum interference can be observed when single particles arrive at the detector one by one. The build-up of such patterns in experiments with electrons has been described as the "most beautiful experiment in physics". Here, we show how a combination of nanofabrication and nano-imaging allows us to record the full two-dimensional build-up of quantum interference patterns in real time for phthalocyanine molecules and for derivatives of phthalocyanine molecules, which have masses of 514 AMU and 1,298 AMU respectively. A laser-controlled micro-evaporation source was used to produce a beam of molecules with the required intensity and coherence, and the gratings were machined in 10-nm-thick silicon nitride membranes to reduce the effect of van der Waals forces. Wide-field fluorescence microscopy detected the position of each molecule with an accuracy of 10 nm and revealed the build-up of a deterministic ensemble interference pattern from single molecules that arrived stochastically at the detector. In addition to providing this particularly clear demonstration of wave-particle duality, our approach could also be used to study larger molecules and explore the boundary between quantum and classical physics.

Real-time single-molecule imaging of quantum interference

NASA Astrophysics Data System (ADS)

Juffmann, Thomas; Milic, Adriana; Müllneritsch, Michael; Asenbaum, Peter; Tsukernik, Alexander; Tüxen, Jens; Mayor, Marcel; Cheshnovsky, Ori; Arndt, Markus

2012-05-01

The observation of interference patterns in double-slit experiments with massive particles is generally regarded as the ultimate demonstration of the quantum nature of these objects. Such matter-wave interference has been observed for electrons, neutrons, atoms and molecules and, in contrast to classical physics, quantum interference can be observed when single particles arrive at the detector one by one. The build-up of such patterns in experiments with electrons has been described as the ``most beautiful experiment in physics''. Here, we show how a combination of nanofabrication and nano-imaging allows us to record the full two-dimensional build-up of quantum interference patterns in real time for phthalocyanine molecules and for derivatives of phthalocyanine molecules, which have masses of 514 AMU and 1,298 AMU respectively. A laser-controlled micro-evaporation source was used to produce a beam of molecules with the required intensity and coherence, and the gratings were machined in 10-nm-thick silicon nitride membranes to reduce the effect of van der Waals forces. Wide-field fluorescence microscopy detected the position of each molecule with an accuracy of 10 nm and revealed the build-up of a deterministic ensemble interference pattern from single molecules that arrived stochastically at the detector. In addition to providing this particularly clear demonstration of wave-particle duality, our approach could also be used to study larger molecules and explore the boundary between quantum and classical physics.

Evidence for ancient atmospheric xenon in Archean rocks and implications for the early evolution of the atmosphere

NASA Astrophysics Data System (ADS)

Pujol, M.; Marty, B.; Burnard, P.; Hofmann, A.

2012-12-01

The initial atmospheric xenon isotopic composition has been much debated over the last 4 decades. A Non radiogenic Earth Atmospheric xenon (NEA-Xe) composition has been proposed to be the best estimate of the initial signature ([1]). NEA-Xe consists of modern atmospheric Xe without fission (131-136Xe) or radioactive decay (129Xe) products. However, the isotope composition of such non-radiogenic xenon is very different to that of potential cosmochemical precursors such as solar or meteoritic Xe, as it is mass-fractionated by up to 3-4 % per amu relative to the potential precursors, and it is also elementally depleted relative to other noble gases. Because the Xe isotopic composition of the Archean appears to be intermediate between that of these cosmochemical end-members and that of the modern atmosphere, we argued that isotopic fractionation of atmospheric xenon did not occur early in Earth's history by hydrodynamic escape, as postulated by all other models ([1], [2], [3]), but instead was a continuous, long term process that lasted during at least the Hadean and Archean eons. Taken at face value, the decrease of the Xe isotopic fractionation from 1.6-2.1 % amu-1 3.5 Ga ago ([4]) to 1 % amu-1 3.0 Ga ago (Ar-Ar age in fluid inclusions trapped in quartz from the same Dresser Formation, [5]) could reflect a secular variation of the atmospheric Xe signature. Nevertheless, up until now, all data showing an isotopic mass fractionation have been measured in rocks and fluids from the same formation (Dresser Formation, Western Australia, aged 3.5 Ga), and have yet to be confirmed in rocks from different locations. In order to better constrain xenon isotopic fractionation of the atmosphere through time, we decided to analyze barites from different ages, geological environments and metamorphism grade. We started this study with barite from the Fig Tree Formation (South Africa, aged 3.26 Ga). This barite was sampled in old mines so have negligible modern exposure time. It is well preserved (no apparent metamorphism) and was deposited in a shallow submarine environment ("Finger type" barites) associated with hydrothermal circulation (white smokers). Compared to barite from the Dresser formation, Fig Tree barite had a long ancient exposure time in the subsurface (under shallow water for example) resulting in huge excesses of 131Xe (131Xe/130Xe ratio ~38 compared to 5.213 for the modern atmosphere one) due to 130Ba(n,γ) reactions. Fissiogenic products (132 to 136Xe) are also more present than in barites from the Dresser Formation and are compatible with the age of the Fig Tree formation. Despite corrections for secondary productions that are hard to constrain, the Fig Tree barite still shows an isotopic mass fractionation of about 1% amu-1, consistent with our expected atmospheric fractionation evolution. [1] Pepin R. O. (1991) Icarus 92(1), 2-79. [2] Dauphas N. (2003) Icarus 165, 326-339. [3] Tolstikhin I. and O'Nions R.K. (1994) Chem. Geol. 115, 1-6. [4] Pujol M., Marty B., Burnard P. and Philippot P. (2009) Geochim. Cosmochim. Acta 73, 6834-46. [5] Pujol M., Marty B. and Burgess R. (2011) Earth Planet. Sci. Lett. 308, 298-306

The SPES High Power ISOL production target

NASA Astrophysics Data System (ADS)

Andrighetto, A.; Corradetti, S.; Ballan, M.; Borgna, F.; Manzolaro, M.; Scarpa, D.; Monetti, A.; Rossignoli, M.; Silingardi, R.; Mozzi, A.; Vivian, G.; Boratto, E.; De Ruvo, L.; Sattin, N.; Meneghetti, G.; Oboe, R.; Guerzoni, M.; Margotti, A.; Ferrari, M.; Zenoni, A.; Prete, G.

2016-11-01

SPES (Selective Production of Exotic Species) is a facility under construction at INFN-LNL (Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali di Legnaro), aimed to produce intense neutron-rich radioactive ion beams (RIBs). These will be obtained using the ISOL (Isotope Separation On-Line) method, bombarding a uranium carbide target with a proton beam of 40MeV energy and currents up to 200μA. The target configuration was designed to obtain a high number of fissions, up to 1013 per second, low power deposition and fast release of the produced isotopes. The exotic isotopes generated in the target are ionized, mass separated and re-accelerated by the ALPI superconducting LINAC at energies of 10AMeV and higher, for masses in the region of A = 130 amu , with an expected rate on the secondary target up to 109 particles per second. In this work, recent results on the R&D activities regarding the SPES RIB production target-ion source system are reported.

Observations of ultraheavy cosmic ray particles at 10 GV cutoff rigidity

NASA Technical Reports Server (NTRS)

Yanagimachi, T.; Hisano, K.; Ito, K.; Kobayashi, S.; Doke, T.; Hamasaki, R.; Hayashi, T.; Yakenaka, T.; Nagata, K.

1985-01-01

Ultraheavy cosmic ray particles with Z 45 and Fe were observed in two balloon flights at a mean geomagnetic cutoff rigidity of 10 GV. Fluxes of these particles at the top of the atmosphere are presented. A ratio of (Z 45)/(Fe) is compared with other experimental results. The ratio decreases with increasing energy in the energy range from 1 to 10 GeV/amu. A possibility is presented to explain the variation of the ratio with energy.

Irradiation chamber and sample changer for biological samples

NASA Astrophysics Data System (ADS)

Kraft, G.; Daues, H. W.; Fischer, B.; Kopf, U.; Liebold, H. P.; Quis, D.; Stelzer, H.; Kiefer, J.; Schöpfer, F.; Schneider, E.; Weber, K.; Wulf, H.; Dertinger, H.

1980-01-01

This paper describes an irradiation system with which living cells of different origin are irradiated with heavy ion beams (18⩽ Z⩽92) at energies up to 10 MeV/amu. The system consists of a beam monitor connected to the vacuum system of the accelerator and the irradiation chamber, containing the biological samples under atmospheric pressure. The requirements and aims of the set up are discussed. The first results with saccharomyces cerevisiae and Chinese Hamster tissue cells are presented.

Isotopic composition of cosmic ray nuclei with Z greater than or equal to 10

NASA Technical Reports Server (NTRS)

Webber, W. R.; Lezniak, J. A.; Kish, J.

1974-01-01

Results of measurements of the isotopic composition of Z greater than or equal to 10 cosmic ray nuclei using a new technique employing a combination of Cerenkov and total energy counters. An effective mass resolution of about 0.4 AMU is obtained for particles with energies between 400 and 500 MeV/nuc and charges between 12 and 16. The preliminary mass distribution of nuclei with charges from 12 to 28 is presented and discussed.

Aral Sea in Uzbekastan seen from STS-59

NASA Image and Video Library

1994-04-14

STS059-L22-140 (9-20 April 1994) --- View northeastward across Uzbekastan to the partly-ice-covered Aral Sea and Kazakhstan. The irrigated fan-delta of the Amu Darya extends from the right side of the photograph to end in extensive salt flats at the south end of the sea. The Aral was the fourth-largest inland sea or lake in the world, until diversion and over-use of the river water for irrigation led, in this arid climate, to the sea's decline. Linhof camera.

A measurement of the energy spectra of cosmic rays from 20 to 1000 GeV per AMU

NASA Technical Reports Server (NTRS)

Gregory, John C.; Smith, Arthur

1994-01-01

During the report period the BUGS-4 instrument was completed, and the maiden voyage took place on 29 September from Fort Sumner, New Mexico. The successful flight of a large spherical drift chamber is a unique first for the sub-orbital balloon program. Unfortunately the instrument was consumed by fire after striking a power line during landing. However, while at float altitude, circa 24 hours of data were telemetered. The pre-flight preparations, and flight operations are described.

Structure, Bonding and Surface Chemistry of Metal Oxide Nanoclusters

DTIC Science & Technology

2015-06-23

studies to cobalt and chromium oxides and to both oxides and pure metal clusters of aluminum, using acetonitrile as the ligand. The chromium solutions...seen in molecular beam experiments. The cobalt oxide sample produced a blue solution, and mass spectra had a single main peak at 551 amu. Mass...of cobalt and nickel oxide cluster cations," J. Phys. Chem. A 116, 5398-5404 (2012). DOI: 10.1021/jp302560p. 4. A. M. Ricks, A. D. Brathwaite, M

Forecasting Cool Season Daily Peak Winds at Kennedy Space Center and Cape Canaveral Air Force Station

NASA Technical Reports Server (NTRS)

Barrett, Joe, III; Short, David; Roeder, William

2008-01-01

The expected peak wind speed for the day is an important element in the daily 24-Hour and Weekly Planning Forecasts issued by the 45th Weather Squadron (45 WS) for planning operations at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). The morning outlook for peak speeds also begins the warning decision process for gusts ^ 35 kt, ^ 50 kt, and ^ 60 kt from the surface to 300 ft. The 45 WS forecasters have indicated that peak wind speeds are a challenging parameter to forecast during the cool season (October-April). The 45 WS requested that the Applied Meteorology Unit (AMU) develop a tool to help them forecast the speed and timing of the daily peak and average wind, from the surface to 300 ft on KSC/CCAFS during the cool season. The tool must only use data available by 1200 UTC to support the issue time of the Planning Forecasts. Based on observations from the KSC/CCAFS wind tower network, surface observations from the Shuttle Landing Facility (SLF), and CCAFS upper-air soundings from the cool season months of October 2002 to February 2007, the AMU created multiple linear regression equations to predict the timing and speed of the daily peak wind speed, as well as the background average wind speed. Several possible predictors were evaluated, including persistence, the temperature inversion depth, strength, and wind speed at the top of the inversion, wind gust factor (ratio of peak wind speed to average wind speed), synoptic weather pattern, occurrence of precipitation at the SLF, and strongest wind in the lowest 3000 ft, 4000 ft, or 5000 ft. Six synoptic patterns were identified: 1) surface high near or over FL, 2) surface high north or east of FL, 3) surface high south or west of FL, 4) surface front approaching FL, 5) surface front across central FL, and 6) surface front across south FL. The following six predictors were selected: 1) inversion depth, 2) inversion strength, 3) wind gust factor, 4) synoptic weather pattern, 5) occurrence of precipitation at the SLF, and 6) strongest wind in the lowest 3000 ft. The forecast tool was developed as a graphical user interface with Microsoft Excel to help the forecaster enter the variables, and run the appropriate regression equations. Based on the forecaster's input and regression equations, a forecast of the day's peak and average wind is generated and displayed. The application also outputs the probability that the peak wind speed will be ^ 35 kt, 50 kt, and 60 kt.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ford, A.L.; Reading, J.F.; Becker, R.L.

Theoretical methods used previously for H/sup +/, He/sup 2 +/, and C/sup 6 +/ collisions with neutral argon atoms have been applied to collisions of H/sup +/, He/sup 2 +/, and Li/sup 3 +/ projectiles with neon, and to collisions of H/sup +/ with carbon targets. The energy range covered by the calculations is 0.4 to 4.0 MeV/amu for the neon target, and 0.2 to 2.0 MeV/amu for carbon. We calculate single-electron amplitudes for target K-shell ionization and target K- and L-shell, to projectile K-shell, charge transfer. These single-electron amplitudes are used, in an independent-particle model that allows for multielectronmore » processes, to compute K-shell vacancy production cross sections sigma/sup IPM//sub V/K, and cross sections sigma/sup IPM//sub C/,VK for producing a charge-transfer state of the projectile in the coincidence with a K-shell vacancy in the target. These cross sections are in reasonable agreement with the recent experiments of Rodbro et al. at Aarhus. In particular, the calculated, as well as the experimental, sigma/sub C/,VK scale with projectile nuclear charge Z/sub p/ less strongly than the Z/sup 5//sub p/ of the Oppenheimer-Brinkman-Kramers (OBK) approximation. For He/sup 2 +/ and Li/sup 3 +/ projectiles at collision energies below where experimental data are available, our calculated multielectron corrections to the single-electron approximation for sigma/sub C/,VK are large.« less

Accelerated heavy particles and the lens. VII: The cataractogenic potential of 450 MeV/amu iron ions

NASA Technical Reports Server (NTRS)

Worgul, B. V.; Brenner, D. J.; Medvedovsky, C.; Merriam, G. R. Jr; Huang, Y.

1993-01-01

PURPOSE. To determine the cataractogenic potential dose of high velocity iron ions as a fixation of dose administered singly or fractionated. The dose is critical to risk assessment and to theories of radiation action and cataractogenesis. METHODS. Twenty-eight-day-old rats were examined by slit-lamp biomicroscopy on a weekly-bi-weekly basis for more than 2 yr after radiation exposure. For the acute exposure study doses of 1, 2, 5, 25, and 50 cGy were evaluated. The fractionated regimens involved total doses of 2, 25, and 50 cGy. The reference radiation consisted of 50, 100, 200, or 700 cGy of 250 kilovolt (peak) x-rays. RESULTS. In accordance with previous findings in the rat using 570 MeV/amu 40Ar ions, the relative biologic effectiveness increased rapidly with decreasing dose, reaching values as high as 100. Unlike 40Ar ions, fractionation of the 56Fe doses did not produce a consistent enhancement at any of the doses examined. CONCLUSIONS. The data support the previous findings of a high cataractogenic potential for high linear energy transfer (LET) radiation. The effectiveness for the production of cataracts increases with decreasing dose relative to x-rays and is independent of dose protraction. Although the present study did not reveal a consistent enhancement of effect when the ions were applied in fractions, the results are consistent with at least one theory of the inverse dose-rate effect observed for high-LET radiation.

Enceladus's Plumes: A Rocket Analogy

NASA Astrophysics Data System (ADS)

McNutt, R. L.; Perry, M. E.; Waite, J. H.; Fletcher, G.; Cravens, T. E.

2009-12-01

The plumes of Enceladus, and the source of the E-ring in the Saturnian system, easily rank as the major, significant, and unexpected discovery of the Cassini mission. While clearly the source of the E-ring,the nature of the sources and the energetics and dynamics of the plumes and underlying jets remains a subject of intensive study. Refinements of the observations suggest supersonic flow of the primary, water-vapor effluent. Such behavior implies a sonic critical point in the flow beginning from a heated reservoir of vapor, through a constriction, and out at supersonic speeds in the space above the plume/jet channels. Such geometry and thermal conditions mimic that of a de Laval nozzle, such as used in rocket engines for converting chemically heated combustion products into a directional flow. A chamber temperature of 180K suggests an outflow speed as high as 0.8 km/s. With a column density across a jet of ~3 x 1016 cm-2 (about twice that of the broad plume) and a jet width of ~10 km, the implied outflow of water molecules is ~3 x 1010 cm-3 x π/4 (106 cm)2 x 18 amu x 1.66 x 10-27 amu/kg x 8 x 104 cm/s = ~60 kg/s in each constituent jet, of which eight were identified by the Cassini Ultraviolet Imaging Spectrograph (UVIS) during the occultation measurements of the plume region of Enceladus carried out on 24 October 2007.

Xe- and U-tracks in apatite and muscovite near the etching threshold

NASA Astrophysics Data System (ADS)

Wauschkuhn, Bastian; Jonckheere, Raymond; Ratschbacher, Lothar

2015-01-01

Ion irradiation of a wedge-shaped Durango apatite backed by a mica detector allows investigating ion track ranges and etching properties at different points along the tracks. Transmission profiles obtained by irradiation with 2 × 106 cm-2 11.1 MeV/amu 132Xe and 2 × 106 cm-2 11.1 MeV/amu 238U parallel to the apatite c-axis correspond to ranges calculated with SRIM (Xe: 76.3 μm; U: 81.1 μm). However, the measured profiles show much greater etchable track-length variations than the calculated longitudinal straggles. The probable cause is that the length deficit exhibits significant variation from track to track. The measured length deficit in muscovite is in agreement with most existing data. In contrast, the length deficit in apatite appears to be close to zero, which is in conflict with all earlier estimates. This probably results from the etching properties of the apatite basal face, which permit surface-assisted sub-threshold etching of track sections in the nuclear stopping regime. These sections are not accessible from the opposite direction, i.e. by etching towards the endpoint of the tracks or in the direction of the ion beam. This conclusion is supported by the fact that linear dislocations are revealed in apatite basal faces and by the observation of imperfect etch pits that are separated from the etched ion track channel by a section that appears unetched under the microscope.

Use of molecular modeling to determine the interaction and competition of gases within coal for carbon dioxide sequestration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeffrey D. Evanseck; Jeffry D. Madura; Jonathan P. Mathews

2006-04-21

Molecular modeling was employed to both visualize and probe our understanding of carbon dioxide sequestration within a bituminous coal. A large-scale (>20,000 atoms) 3D molecular representation of Pocahontas No. 3 coal was generated. This model was constructed based on a the review data of Stock and Muntean, oxidation and decarboxylation data for aromatic clustersize frequency of Stock and Obeng, and the combination of Laser Desorption Mass Spectrometry data with HRTEM, enabled the inclusion of a molecular weight distribution. The model contains 21,931 atoms, with a molecular mass of 174,873 amu, and an average molecular weight of 714 amu, with 201more » structural components. The structure was evaluated based on several characteristics to ensure a reasonable constitution (chemical and physical representation). The helium density of Pocahontas No. 3 coal is 1.34 g/cm{sup 3} (dmmf) and the model was 1.27 g/cm{sup 3}. The structure is microporous, with a pore volume comprising 34% of the volume as expected for a coal of this rank. The representation was used to visualize CO{sub 2}, and CH{sub 4} capacity, and the role of moisture in swelling and CO{sub 2}, and CH{sub 4} capacity reduction. Inclusion of 0.68% moisture by mass (ash-free) enabled the model to swell by 1.2% (volume). Inclusion of CO{sub 2} enabled volumetric swelling of 4%.« less

Examples of the Zeroth Theorem of the History of Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, J.D.

2007-08-24

The zeroth theorem of the history of science, enunciated byE. P. Fischer, states that a discovery (rule,regularity, insight) namedafter someone (often) did not originate with that person. I present fiveexamples from physics: the Lorentz condition partial muAmu = 0 definingthe Lorentz gauge of the electromagnetic potentials; the Dirac deltafunction, delta(x); the Schumann resonances of the earth-ionospherecavity; the Weizsacker-Williams method of virtual quanta; the BMTequation of spin dynamics. I give illustrated thumbnail sketches of boththe true and reputed discoverers and quote from their "discovery"publications.

Manipulating ion-atom collisions with coherent electromagnetic radiation.

PubMed

Kirchner, Tom

2002-08-26

Laser-assisted ion-atom collisions are considered in terms of a nonperturbative quantum mechanical description of the electronic motion. It is shown for the system He(2+) - H at 2 keV/amu that the collision dynamics depend strongly on the initial phase of the laser field and the applied wavelength. Whereas electronic transitions are caused by the concurrent action of the field and the projectile ion at relatively low frequencies, they can be separated into modified collisional capture and field ionization events in the region above the one-photon ionization threshold.

Analysis of Biologic Samples for Morphine and Morphine-Related Compounds by Gas Chromatographic-Mass Spectrometric Methods

DTIC Science & Technology

1976-04-01

spectra are obtained for each peak detected in the CC effluent stream. In this mode of operation, the "total ion current" is usually used as a guide...correcting drift for both magnetic field and electrical field instruments. The peak setting is usually made to the 47 nearest 0.1 amu, and adjustments...su stances by charge transfer from nitric oxide ions (No ), however, the M14 ions are the base peak . This obser- vation by Jardine and Fenselau (44

A survey of heavy ions in Titan's ionosphere

NASA Astrophysics Data System (ADS)

Crary, Frank

2016-06-01

The Cassini Plasma Spectrometer (CAPS) has observed heavy positive ions, with masses up to approximately 300 amu, as well as negative ions with even higher masses. The abundance and density of these positive ions have been reported for selected encounters, especially during those where comparisons with Ion and Neutral Mass Spectrometer (INMS) data are possible. The present work presents a survey of all available encounters, showing the density of ions in various mass ranges and their spatial distribution. The influence of the broad mass distribution on ionospheric conductivity will also be discussed.

Neon-20 depth-dose relations in water

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Townsend, L. W.; Bidasaria, H. B.; Schimmerling, W.; Wong, M.; Howard, J.

1984-01-01

The dose from heavy ion beams has been calculated using a one-dimensional transport theory and evaluated for 670 MeV/amu 20 Ne beams in water. The result is presented so as to be applicable to arbitrary ions for which the necessary interaction data are known. The present evaluation is based on thar Silberg-Tsao fragmentation parameters augmented with light fragment production from intranuclear cascades, recently calculated nuclear absorption cross sections, and evaluated stopping power data. Comparison with recent experimental data obtained at the Lawrence Berkeley Laboratory reveals the need for more accurate fragmentation data.

Neon-20 depth-dose relations in water

NASA Astrophysics Data System (ADS)

Wilson, J. W.; Townsend, L. W.; Bidasaria, H. B.; Schimmerling, W.; Wong, M.; Howard, J.

1984-05-01

The dose from heavy ion beams has been calculated using a one-dimensional transport theory and evaluated for 670 MeV/amu 20 Ne beams in water. The result is presented so as to be applicable to arbitrary ions for which the necessary interaction data are known. The present evaluation is based on thar Silberg-Tsao fragmentation parameters augmented with light fragment production from intranuclear cascades, recently calculated nuclear absorption cross sections, and evaluated stopping power data. Comparison with recent experimental data obtained at the Lawrence Berkeley Laboratory reveals the need for more accurate fragmentation data.

Growth of the Pamir

NASA Astrophysics Data System (ADS)

Gloaguen, R.; Ratschbacher, L.

2009-04-01

We aim to establish the Late Cenozoic deformation field of the Pamir by localizing and characterizing active and neotectonic deformation structures, and setting up the drainage-basin, river-capture, river- reversal, and regional erosion history. The project thus aims to record the short-term, upper crustal response to active intra-continental subduction, orocline formation, and erosion. Our hypothesis is that the neotectonics is governed by subduction beneath the frontal part of the orocline, E-W extension in the intra-plateau Karakul-lake rift, and transtension (east) and transpression (west) along the lateral margins of the orocline, a result of oroclinal formation, rotation of the Indian indenter, and focused precipitation caused by the Westerlies. The model for the evolution of the drainage system involves: growth of the Pamir by N-ward propagating deformation, establishing E-trending belts of shortening and rivers/drainages; diversion and blocking of these rivers by the development of the lateral boundaries of the orocline that resulted in river capture and reversal. Even the present-day Panj (Amu Darya) is affected by ongoing uplift: tilted river terraces, wind gaps, and abnormal intersection of streams of different order indicate that large parts of the river have changed flow direction. The determination of a number of geomorphic indices with remote sensing techniques help us to identify areas experiencing tectonic deformation.

Comment on "Zircon U-Th-Pb dating using LA-ICP-MS: Simultaneous U-Pb and U-Th dating on 0.1 Ma Toya Tephra, Japan" by Hisatoshi Ito

NASA Astrophysics Data System (ADS)

Guillong, M.; Schmitt, A. K.; Bachmann, O.

2015-04-01

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) of eight zircon reference materials and synthetic zircon-hafnon end-members indicate that corrections for abundance sensitivity and molecular zirconium sesquioxide ions (Zr2O3+) are critical for reliable determination of 230Th abundances in zircon. Other polyatomic interferences in the mass range 223-233 amu are insignificant. When corrected for abundance sensitivity and interferences, activity ratios of (230Th)/(238U) for the zircon reference materials we used average 1.001 ± 0.010 (1σ error; mean square of weighted deviates MSWD = 1.45; n = 8). This includes the 91500 and Plešovice zircons, which were deemed unsuitable for calibration of (230Th)/(238U) by Ito (2014). Uranium series zircon ages generated by LA-ICP-MS without mitigating (e.g., by high mass resolution) or correcting for abundance sensitivity and molecular interferences on 230Th such as those presented by Ito (2014) are potentially unreliable.

Assay of free captopril in human plasma as monobromobimane derivative, using RPLC/(+)ESI/MS/MS: validation aspects and bioequivalence evaluation.

PubMed

Medvedovici, Andrei; Albu, Florin; Sora, Iuliana Daniela; Udrescu, Stefan; Galaon, Toma; David, Victor

2009-10-01

A sensitive method for determination of free captopril as monobromobimane derivative in plasma samples is discussed. The internal standard (IS) was 5-methoxy-1H-benzimidazole-2-thiol. Derivatization with monobromobimane immediately after blood collection and plasma preparation prevents oxidation of captopril to the corresponding disulfide compound and enhances the ionization yield. Consequently, derivatization enhances sample stability and detection sensitivity. Addition of the internal standard was made immediately after plasma preparation. The internal standard was also derivatized by monobromobimane, as it contains a thiol functional group. Preparation of plasma samples containing captopril and IS derivatives was based upon protein precipitation through addition of acetonitrile, in a volumetric ratio 1:2. The reversed-phase liquid chromatographic separation was achieved on a rapid resolution cartridge Zorbax SB-C(18), monitored through positive electrospray ionization and tandem MS detection using the multiple-reaction monitoring mode. Transitions were 408-362 amu for the captopril derivative and 371-260 amu for the internal standard derivative. The kinetics of captopril oxidation to the corresponding disulfide compound in plasma matrix was also studied using the proposed method. A linear log-log calibration was obtained over the concentration interval 2.5-750 ng/mL. A low limit of quantitation in the 2.5 ng/mL range was obtained. The analytical method was fully validated and successfully applied in a three-way, three-period, single-dose (50 mg), block-randomized bioequivalence study for two pharmaceutical formulations (captopril LPH 25 and 50 mg) against the comparator Capoten 50 mg. Copyright (c) 2009 John Wiley & Sons, Ltd.

Prevalence of zoonotic bacteria in wild and farmed aquatic species and seafood: a scoping study, systematic review, and meta-analysis of published research.

PubMed

Tuševljak, Nataša; Rajić, Andrijana; Waddell, Lisa; Dutil, Lucie; Cernicchiaro, Natalia; Greig, Judy; Wilhelm, Barbara J; Wilkins, Wendy; Totton, Sarah; Uhland, F Carl; Avery, Brent; McEwen, Scott A

2012-06-01

Increased reliance on seafood has brought to light concerns regarding food safety, but the information to inform risk assessment or surveillance needs is lacking. A scoping study (ScS) was conducted to characterize published research investigating selected zoonotic bacteria and public health topics in various wild and farmed aquatic species and seafood. This was followed by a systematic review (SR) on selected bacteria (Aeromonas spp., generic Escherichia coli, Salmonella spp., and Vibrio spp.) and aquatic species (clams, mussels, oysters, salmon, and shrimp [including prawn]); a meta-analysis (MA) was conducted only at the retail level due to considerable variability among various pathogen/seafood combinations. The ScS revealed the most frequently investigated themes were farm-level prevalence and intervention research for Vibrio spp. and Aeromonas spp. Antimicrobial use (AMU) and the association between AMU and antimicrobial resistance were rarely investigated. The SR indicated a consistent lack of reporting regarding study methodology and results, precluding the use of many studies in and full benefits of MA. MA of Aeromonas, E. coli, and Salmonella prevalence in retail salmon resulted in pooled estimates of 13% (6-27%), 2% (0.1-11%), and 1% (0-5%), respectively. When MA of pathogen/seafood combination resulted in statistically significant heterogeneity (p<0.1), median/range were reported at the region level. The results from our ScS, SR, and MA could be used for better design of future bacteriological surveys of seafood and as inputs for risk assessments or surveillance initiatives in this field.

Development, validation and utilization of a highly sensitive LC-MS/MS method for quantification of levonorgestrel released from a subdermal implant in human plasma.

PubMed

Cirrincione, Lauren R; Penchala, Sujan Dilly; Scarsi, Kimberly K; Podany, Anthony T; Winchester, Lee C; Back, David J; Khoo, Saye H; Fletcher, Courtney V; Siccardi, Marco; Else, Laura J

2018-05-01

Levonorgestrel (LNG) is a synthetic progestin that is available in oral contraceptive tablets, a subdermal implant, and an intrauterine system for contraception. LNG pharmacokinetics are a pivotal determinant of contraceptive efficacy and essential in assessing drug-drug interactions influencing LNG exposure following different routes of LNG administration. A highly sensitive LC-MS/MS method was developed and validated to quantify levonorgestrel in human plasma. Liquid-liquid extraction was utilized with a sample volume of 500 μL to extract levonorgestrel from plasma. Chromatographic separation of LNG was achieved with a Fortis™ C18 (3 μm: 100 mm × 2.1 mm) reverse phase analytical column. The mobile phases consisted of de-ionized water plus 0.1% NH 4 OH (100:0.1%, v/v) (A), and methanol plus 0.1% NH 4 OH (100:0.1%, v/v) (B) delivered as a gradient at a flow rate of 400 μL/min. Detection of LNG and internal standard (D-(-)-norgestrel-d7) was achieved using positive polarity mode monitoring at 313.2-245.2 amu and 320.1-251.2 amu, respectively. The assay was linear over the calibration range of 49.6 to 1500 pg/mL. This method was used to quantify plasma LNG released by subdermal implant in support of a drug interaction study among women with HIV receiving efavirenz- or nevirapine-based antiretroviral therapy. Copyright © 2018 Elsevier B.V. All rights reserved.

Geology and hydrocarbon habitat of the Amu-Darya region (central Asia)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoecklin, J.; Orassianou, T.

1991-08-01

The Amu-Darya region, shared by the Soviet Republics of Turkmenistan, Uzbekistan, and Tadzhikistan, is the second-largest gas province of the USSSR after western Siberia both production and reserves. Its more than 180 gas, gas-condensate, and minor oil fields include 6 giants with reserves of over 3 tcf, such as the Sovietabad field of eastern Turkmenistan, which in 1989 produced nearly 1 tcf of gas and which had an initial recoverable reserve of 38 tcf of gas. oil in addition to gas is produced mainly in the eastern Uzbekian and Tadzhikian parts. The region represents a large depression covering the southeasternmore » portion of the epi-Hercynian Turan platform to the north of the Alpine-Himalayan fold belts of northeastern Iran and northern Afghanistan. Continental, paralic, lagoonal, and shallow-marine environments characterized Mesozoic-Tertiary platform sedimentation, with maximum sediment thicknesses of about 10 km in the Alpine foredeeps at the southern platform margin. Large amounts of essentially gas-prone organic matter accumulated in the Late Triassic to Middle Jurassic. Main hydrocarbon reservoirs are Callovian-Oxfordian shelf-platform and reefal carbonates under cover of thick Kimmeridgian-Tithonian salt, and shale-sealed Lower Cretaceous continental and near-shore deltaic sandstones. In the Tadzhik basin in the extreme east, oil is contained in Lower Tertiary fractured carbonates interbedded with bituminous shales. Synsedimentary differential movements and gently folding in the Miocene to Pliocene were the main trap mechanisms. The region has still a considerable undrilled future potential, particularly in its deeper southern parts.« less

Observations of metal concentrations in E-region sporadic thin layers using incoherent-scatter radar

NASA Astrophysics Data System (ADS)

Suzuki, Nobuhiro

This thesis has used incoherent-scatter radar data from the facility at Sondrestrom, Greenland to determine the ion mass values inside thin sporadic-E layers in the lower ionosphere. Metallic positively-charged ions of meteoric origin are deposited in the earth's upper atmosphere over a height range of about 85-120 km. Electric fields and neutral-gas (eg N2, O, O2) winds at high latitudes may produce convergent ion dynamics that results in the re-distribution of the background altitude distribution of the ions to form thin (1-3 km) high-density layers that are detectable with radar. A large database of experimental radar observations has been processed to determine ion mass values inside these thin ion layers. The range resolution of the radar was 600 meters that permitted mass determinations at several altitude steps within the layers. Near the lower edge of the layers the ion mass values were in the range 20-25 amu while at the top portion of the layers the mass values were generally in the range 30-40 amu. The numerical values are consistent with in-situ mass spectrometer data obtained by other researchers that suggest these layers are mainly composed of a mixture or Mg +, Si+, and Fe + ions. The small tendency for heavier ions to reside at the top portion of the layers is consistent with theory. The results have also found new evidence for the existence of complex-shaped multiple layers; the examples studied suggest similar ion mass values in different layers that in some cases are separated in altitude by several km.

Evaporation and Accompanying Isotopic Fractionation of Sulfur from FE-S Melt During Shock Wave Heating

NASA Technical Reports Server (NTRS)

Tachibana, S.; Huss, G. R.; Miura, H.; Nakamoto, T.

2004-01-01

Chondrules probably formed by melting and subsequent cooling of solid precursors. Evaporation during chondrule melting may have resulted in depletion of volatile elements in chondrules. It is known that kinetic evaporation, especially evaporation from a melt, often leads to enrichment of heavy isotopes in an evaporation residue. However, no evidence for a large degree of heavy-isotope enrichment has been reported in chondrules for K, Mg, Si, and Fe (as FeO). The lack of isotopic fractionation has also been found for sulfur in troilites (FeS) within Bishunpur (LL3.1) and Semarkona (LL3.0) chondrules by an ion microprobe study. The largest fractionation, found in only one grain, was 2.7 +/- 1.4 %/amu, while all other troilite grains showed isotopic fractionations of <1 %/amu. The suppressed isotopic fractionation has been interpreted as results of (i) rapid heating of precursors at temperatures below the silicate solidus and (ii) diffusion-controlled evaporation through a surrounding silicate melt at temperatures above the silicate solidus. The kinetic evaporation model suggests that a rapid heating rate of >10(exp 4)-10(exp 6) K/h for a temperature range of 1000-1300 C is required to explain observed isotopic fractionations. Such a rapid heating rate seems to be difficult to be achieved in the X-wind model, but can be achieved in shock wave heating models. In this study, we have applied the sulfur evaporation model to the shock wave heating conditions of to evaluate evaporation of sulfur and accompanying isotopic fractionation during shock wave heating at temperatures below the silicate solidus.

Statistical Analysis of Model Data for Operational Space Launch Weather Support at Kennedy Space Center and Cape Canaveral Air Force Station

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2010-01-01

The 12-km resolution North American Mesoscale (NAM) model (MesoNAM) is used by the 45th Weather Squadron (45 WS) Launch Weather Officers at Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) to support space launch weather operations. The 45 WS tasked the Applied Meteorology Unit to conduct an objective statistics-based analysis of MesoNAM output compared to wind tower mesonet observations and then develop a an operational tool to display the results. The National Centers for Environmental Prediction began running the current version of the MesoNAM in mid-August 2006. The period of record for the dataset was 1 September 2006 - 31 January 2010. The AMU evaluated MesoNAM hourly forecasts from 0 to 84 hours based on model initialization times of 00, 06, 12 and 18 UTC. The MesoNAM forecast winds, temperature and dew point were compared to the observed values of these parameters from the sensors in the KSC/CCAFS wind tower network. The data sets were stratified by model initialization time, month and onshore/offshore flow for each wind tower. Statistics computed included bias (mean difference), standard deviation of the bias, root mean square error (RMSE) and a hypothesis test for bias = O. Twelve wind towers located in close proximity to key launch complexes were used for the statistical analysis with the sensors on the towers positioned at varying heights to include 6 ft, 30 ft, 54 ft, 60 ft, 90 ft, 162 ft, 204 ft and 230 ft depending on the launch vehicle and associated weather launch commit criteria being evaluated. These twelve wind towers support activities for the Space Shuttle (launch and landing), Delta IV, Atlas V and Falcon 9 launch vehicles. For all twelve towers, the results indicate a diurnal signal in the bias of temperature (T) and weaker but discernable diurnal signal in the bias of dewpoint temperature (T(sub d)) in the MesoNAM forecasts. Also, the standard deviation of the bias and RMSE of T, T(sub d), wind speed and wind direction indicated the model error increased with the forecast period all four parameters. The hypothesis testing uses statistics to determine the probability that a given hypothesis is true. The goal of using the hypothesis test was to determine if the model bias of any of the parameters assessed throughout the model forecast period was statistically zero. For th is dataset, if this test produced a value >= -1 .96 or <= 1.96 for a data point, then the bias at that point was effectively zero and the model forecast for that point was considered to have no error. A graphical user interface (GUI) was developed so the 45 WS would have an operational tool at their disposal that would be easy to navigate among the multiple stratifications of information to include tower locations, month, model initialization times, sensor heights and onshore/offshore flow. The AMU developed the GUI using HyperText Markup Language (HTML) so the tool could be used in most popular web browsers with computers running different operating systems such as Microsoft Windows and Linux.

Definition Study of a Coordinated Group of Experiments to Measure and Monitor the in situ Plasma and Electromagnetic Environment of a Polar Orbiting Space Shuttle.

DTIC Science & Technology

1985-09-01

instruments should be included in the SACS package: Mass Spectrometer - The ion/neutral quadrupole mass spectrometer obtains composition measurements of...contamination. The preferred direction is into the RAM. The field-of-view is _ 200 and t ie mass range is 1 to 64 AMU.- Energetic Particle Deteotors...Dimensions Dimensions Weight Item Stowed (cm) Deployed (cm) (kg) Ejected Recovery Mass Spectrometer N/A 15x7x7 bxbx6 12.7 N/A N/A Energetic Particle Det N

The open-source neutral-mass spectrometer on Atmosphere Explorer-C, -D, and -E.

NASA Technical Reports Server (NTRS)

Nier, A. O.; Potter, W. E.; Hickman, D. R.; Mauersberger, K.

1973-01-01

The open-source mass spectrometer will be used to obtain the number densities of the neutral atmospheric gases in the mass range 1 to 48 amu at the satellite location. The ion source has been designed to allow gas particles to enter the ionizing region with the minimum practicable number of prior collisions with surfaces. This design minimizes the loss of atomic oxygen and other reactive species due to reactions with the walls of the ion source. The principal features of the open-source spectrometer and the laboratory calibration system are discussed.

Duluth, Duluth IAP, Minnesota. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1983-08-01

0iu.A . Al. AL..? 91,. 041.1 DION of- a* 1 AA .D IC If tAL MaiE OF OUSYAINW1 ICUSAF ETAC 0- 14.5 (0k A) aI Fa p..oew m amu... CELIN 39, 43 1 . 11 o 1. 61. *1. 61.4o o1 11 .1 61. je 1 611 1. 1 1.1 61.1 41. 1 20000 166, l l... 7 Lj17 47l8) 4l.) 4l) 8la %7-8 47. - .-XI" 47 1 7

Modelling the influence of irrigation on the shrinking Aral Sea

NASA Astrophysics Data System (ADS)

Aus der Beek, Tim; Voss, Frank; Floerke, Martina

2010-05-01

The Aral Sea is fed by two tributaries, the Amu Darya and the Syr Darya, and often is considered as one of the most complex hydrological basins of the world. The shrinkage of the Aral Sea during the last 50 years, which has been caused by excessive irrigation projects, has led to numerous ecological, human and economical problems. This study focuses on historic modelling (1960-2002) of the Amu Darya (535,000 km²) and the Syr Darya (219,000 km²) to assess the influence of land-use change, i.e. conversion of non-cultivated land to irrigated crops, on the hydrological cycle and on the shrinkage of the Aral Sea. Therefore, we have compiled crop- and irrigation-specific land use maps in five year intervals from extensive literature and data base reviews. These maps are first applied within the WaterGAP irrigation model, which has been further developed to account for the seven major crops of Central Asia, to compute crop-specific net irrigation requirements. In combination with a newly set up data base on time series of irrigation project efficiencies for Iran, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan we have also been able to depict crop-specific gross irrigation requirements. These results have then been applied within the WaterGAP hydrology model, where they alter the water balance of each affected grid cell, and thus, runoff generation. All irrigation and hydrology calculations have been conducted in daily time steps and five arc minutes spatial resolution (~ 8 x 10 km grid cells) for the entire Aral Sea basin. Climate forcing data for the 42 year period has been taken from the CRU TS2.1 data set. First results of this model experiment show that not only massive water abstractions have caused the changes in the hydrological regime of both rivers, but also poor land and water management has taken its toll. Between 1960 and 1990 a state driven land use conversion from locally adapted food crops, such as cereals, to water intensive cash crops, such as cotton, has taken place. This and other factors have led to nearly doubling of water withdrawals within the basin. One further example is the on-going construction of the Karakum Canal, which diverts about 18km³ per year from the Amu Darya to the Karakum Desert, causing immense changes in the hydrograph and inflow to the Aral Sea. Due to poor water management, i.e. transmission losses of up to ~12km³ per year and old irrigation systems, most of the diverted canal water cannot be used for irrigation purposes. The influence of climate change in the Aral Sea basin between 1960 and 2002 is evident. However, excessive water abstractions mask climate change induced hydrological regime changes.

Bright optical centre in diamond with narrow, highly polarised and nearly phonon-free fluorescence at room temperature

NASA Astrophysics Data System (ADS)

John, Roger; Lehnert, Jan; Mensing, Michael; Spemann, Daniel; Pezzagna, Sébastien; Meijer, Jan

2017-05-01

Using shallow implantation of ions and molecules with masses centred at 27 atomic mass units (amu) in diamond, a new artificial optical centre with unique properties has been created. The centre shows a linearly polarised fluorescence with a main narrow emission line mostly found at 582 nm, together with a weak vibronic sideband at room temperature. The fluorescence lifetime is ∼2 ns and the brightest centres are more than three times brighter than the nitrogen-vacancy centres. A majority of the centres shows stable fluorescence whereas some others present a blinking behaviour, at faster or slower rates. Furthermore, a second kind of optical centre has been simultaneously created in the same diamond sample, within the same ion implantation run. This centre has a narrow zero-phonon line (ZPL) at ∼546 nm and a broad phonon sideband at room temperature. Interestingly, optically detected magnetic resonance (ODMR) has been measured on several single 546 nm centres and two resonance peaks are found at 0.99 and 1.27 GHz. In view of their very similar ODMR and optical spectra, the 546 nm centre is likely to coincide with the ST1 centre, reported once (with a ZPL at 550 nm), but of still unknown nature. These new kinds of centres are promising for quantum information processing, sub-diffraction optical imaging or use as single-photon sources.

[Macromolecular aromatic network characteristics of Chinese power coal analyzed by synchronous fluorescence and X-ray diffraction].

PubMed

Ye, Cui-Ping; Feng, Jie; Li, Wen-Ying

2012-07-01

Coal structure, especially the macromolecular aromatic skeleton structure, has a strong influence on coke reactivity and coal gasification, so it is the key to grasp the macromolecular aromatic skeleton coal structure for getting the reasonable high efficiency utilization of coal. However, it is difficult to acquire their information due to the complex compositions and structure of coal. It has been found that the macromolecular aromatic network coal structure would be most isolated if small molecular of coal was first extracted. Then the macromolecular aromatic skeleton coal structure would be clearly analyzed by instruments, such as X-ray diffraction (XRD), fluorescence spectroscopy with synchronous mode (Syn-F), Gel permeation chromatography (GPC) etc. Based on the previous results, according to the stepwise fractional liquid extraction, two Chinese typical power coals, PS and HDG, were extracted by silica gel as stationary phase and acetonitrile, tetrahydrofuran (THF), pyridine and 1-methyl-2-pyrollidinone (NMP) as a solvent group for sequential elution. GPC, Syn-F and XRD were applied to investigate molecular mass distribution, condensed aromatic structure and crystal characteristics. The results showed that the size of aromatic layers (La) is small (3-3.95 nm) and the stacking heights (Lc) are 0.8-1.2 nm. The molecular mass distribution of the macromolecular aromatic network structure is between 400 and 1 130 amu, with condensed aromatic numbers of 3-7 in the structure units.

Binary-encounter electrons observed at 0 degree in collisions of 1--2-MeV/amu H sup + , C sup 6+ , N sup 7+ , O sup 8+ , and F sup 9+ ions with H sub 2 and He targets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, D.H.; Richard, P.; Zouros, T.J.M.

The energy distribution of binary-encounter electrons (BEE) produced in collisions of 1--2 MeV/amu H{sup +} and bare C, N, O, and F ions with H{sub 2} and He gas targets is reported at 0{degree} with respect to the beam direction. These electrons result from ionization of the target due to hard collisions with the projectile and can thus be considered to be produced in a process analogous to elastic scattering of a free electron from a highly charged ion. An impulse-approximation (IA) model has been developed to describe this process in which quasifree'' target electrons undergo 180{degree} Rutherford scattering inmore » the projectile frame. The measured BEE double-differential production cross sections for bare ions were well described by this model and were found to scale with {ital Z}{sub {ital p}}{sup 2} and {ital E}{sub {ital p}}{sup {minus}({similar to}2.6--2.7)} where {ital Z}{sub {ital p}} and {ital E}{sub {ital p}} are the charge and energy of the projectile, respectively. An energy shift of the BEE below 4{ital t}, where {ital t} is the cusp electron energy, is observed and is also predicted by the IA treatment. A plane-wave Born approximation (PWBA) calculation for BEE production is also found to be in overall agreement with our data. However, the energy shift of the BEE peak could not be fully accounted for within this PWBA calculation.« less

Coincidence studies of He ionized by C{sup 6+}, Au{sup 24+}, and Au{sup 53+}

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGovern, M.; Walters, H. R. J.; Assafrao, D.

2010-04-15

A recently developed [Phys. Rev. A 79, 042707 (2009)] impact parameter coupled pseudostate approximation (CP) is applied to calculate triple differential cross sections for single ionization of He by C{sup 6+}, Au{sup 24+}, and Au{sup 53+} projectiles at impact energies of 100 and 2 MeV/amu for C{sup 6+} and 3.6 MeV/amu for Au{sup 24+} and Au{sup 53+}. For C{sup 6+}, satisfactory, but not perfect, agreement is found with experimental measurements in coplanar geometry, but there is substantial disagreement with data taken in a perpendicular plane geometry. The CP calculations firmly contradict a projectile-nucleus interaction model which has been used tomore » support the perpendicular plane measurements. For Au{sup 24+} and Au{sup 53+}, there is a complete lack of accord with the available experiments. However, for Au{sup 24+} the theoretical position appears to be quite firm with clear indications of convergence in the CP approximation and very good agreement between CP and the completely different three-distorted-waves eikonal-initial-state (3DW-EIS) approximation. The situation for Au{sup 53+} is different. At the momentum transfers at which the measurements were made, there are doubts about the convergence of the CP approximation and a factor of 2 difference between the CP and 3DW-EIS predictions. The discord between theory and experiment is even greater with the experiment giving cross sections a factor of 10 larger than the theory. A study of the convergence of the CP approximation shows that it improves rapidly with reducing momentum transfer. As a consequence, lower-order cross sections than the triple are quite well converged and present an opportunity for a more reliable test of the experiment.« less

Preliminary Inventory in the Early Coma of Comet 67P/Churyumov-Gerasimenko

NASA Astrophysics Data System (ADS)

Calmonte, Ursina; Altwegg, Kathrin; Le Roy, Léna; Rubin, Martin; Berthelier, Jean-Jacques; De Keyser, Johan; Fiethe, Björn; Fuselier, Steve A; Combi, Mike

2014-11-01

After a 10-year journey, the European Space Agency’s Rosetta mission encountered its target comet Churyumov-Gerasimenko. Rosetta will accompany the comet to perihelion and beyond. On board the Rosetta spacecraft is the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) experiment. ROSINA consists of a pressure sensor and two complementary mass spectrometers. One is the Double Focusing Mass Spectrometer, which has high dynamic range and a mass resolution m/Δm = 3000 at 1% peak height (m/Δm = 9000 at 50% peak height) at mass 28 amu/q. It is therefore well suited to detect minor species in the lower mass range up to mass 140 amu [1].ROSINA has been taking data since May 2014 and first signals of the comet were detected at the beginning of August. We will present a preliminary inventory of species seen by ROSINA in the early coma of comet Churyumov-Gerasimenko.References[1] Balsiger, H., Altwegg, K., Bochsler, P., Eberhardt, P., Fischer, J., Graf, S., Jäckel, A., Kopp, E., Langer, U., Mildner, M., Müller, J., Riesen, T., Rubin, M., Scherer, S., Wurz, P., Wüthrich, S., Arijs, E., Delanoye, S., de Keyser, J., Neefs, E., Nevejans, D., Rème, H., Aoustin, C., Mazelle, C., Médale, J.-L., Sauvaud, J.A., Berthelier, J.-J., Bertaux, J.-L., Duvet, L., Illiano, J.-M., Fuselier, S.A., Ghielmetti, A.G., Magoncelli, T., Shelley, E.G., Korth, A., Heerlein, K., Lauche, H., Livi, S., Loose, A., Mall, U., Wilken, B., Gliem, F., Fiethe, B., Gombosi, T.I., Block, B., Carignan, G.R., Fisk, L.A., Waite, J.H., Young, D.T. and Wollnik, H.,. Rosina Rosetta Orbiter Spectrometer for Ion and Neutral Analysis, Space Science Reviews 128, pp745-801, 2007.

Petrographic and reservoir features of Hauterivian (Lower Cretaceous) Shatlyk horizon in the Malay gas field, Amu-Darya basin, east Turkmenia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naz, H.; Ersan, A.

1996-08-01

Malay gas field in Amu-Darya basin, eastern Turkmenia, is located on the structural high that is on the Malay-Bagadzha arch north of the Repetek-Kelif structure zone. With 500 km{sup 2} areal coverage, 16 producing wells and 200 billion m{sup 3} estimated reserves, the field was discovered in 1978 and production began in 1987 from 2400-m-deep Hauterivian-age (Early Cretaceous) Shatlyk horizon. The Shatlyk elastic sequence shows various thickness up to 100 m in the Malay structural closure and is studied through E-log, core, petrographic data and reservoir characteristics. The Shatlyk consists of poorly indurated, reddish-brown and gray sandstones, and sandy graymore » shales. The overall sand-shale ratio increases up and the shales interleave between the sand packages. The reservoir sandstones are very fine to medium grained, moderately sorted, compositionally immature, subarkosic arenites. The framework grains include quartz, feldspar and volcanic lithic fragments. Quartz grains are monocrystalline in type and most are volcanic in origin. Feldspars consist of K- Feldspar and plagioclase. The orthoclases are affected by preferential alteration. The sandstones show high primary intergranular porosity and variations in permeability. Patch-like evaporate cement and the iron-rich grain coatings are reducing effects in permeability. The coats are pervasive in reddish-brown sandstones but are not observed in the gray sandstones. The evaporate cement is present in all the sandstone samples examined and, in places, follows the oxidation coats. The petrographic evidences and the regional facies studies suggest the deposition in intersection area from continental to marine nearshore deltaic environment.« less

PAH/Aromatic Tar and Coke Precursor Formation in the Early Stages of Triglyceride (Triolein) Pyrolysis.

PubMed

Alhroub, Ibrahim; Kozliak, Evguenii; Kubátová, Alena; Sulkes, Mark

2018-03-29

There has been a limited understanding of high MW polycyclic aromatic hydrocarbon (PAH) product chemistry in the pyrolysis of triglycerides (TGs), though the subject has important implications for both fuel production from TGs and food science. Previous TG pyrolysis studies have been able to identify only relatively low MW GC-elutable aromatics occurring in the bulk liquid phase; products occurring in the solid phase have remained inaccessible to chemical analysis. In contrast, cold gas expansion molecular beam methods, where pyrolysis products are analyzed in real time as they are entrained in gas expansions, remove product collection difficulties, thereby allowing for analysis of coke/tar PAH precursors. In this study, the model TG triolein was heated and the ensuing products in the molecular beam were soft photoionized, enabling time-of-flight mass detection. Use of 266 nm pulses enabled selective photoionization of aromatic products. Unlike previous work on analysis of the liquid phase TG cracking products, a different and distinct pattern of rather large PAHs, up to 444 amu, was observed, at nontrivial relative product fractions. With an increase of temperature to ∼350 °C, a small number of PAHs with MW ≥ 276 amu increasingly dominated the aromatic product distribution. Surprisingly, PAH product detection ensued at rather low temperatures, as low as ∼260 °C. For tentative PAH product identification and product chemistry rationalization, we observed the product homology pattern and applied a stoichiometric analysis. The latter, combined with the known homology profiles of TG cracking products, indicated specific patterns of intermediate fragment association that facilitated large-MW PAH formation as a result of TG cracking.

Modelling the impact of Global Change on the hydrological system of the Aral Sea basin

NASA Astrophysics Data System (ADS)

Aus der Beek, T.; Voß, F.; Flörke, M.

During the last decades the Aral Sea basin has suffered an enormous depletion of water resources within its lakes and rivers with consequences for society, economy, and nature. Within this model study, Global Change impacts on the Amu Darya and Syr Darya rivers, as well as on the Aral Sea itself, are being analysed for the period 1958-2002. In a first step, a multi-annual data base on crop specific irrigated areas has been set-up, which has then been integrated in the hydrology and water use model WaterGAP3. As a second step, anthropogenic water abstractions have been calculated, which were then assimilated in the simulation of river runoff of the Amu Darya and Syr Darya. The last step includes the simulation of the water balance of the Aral Sea, by taking into account modelled river inflow. Within WaterGAP3, the water use module has been switched on and off to separate the impacts of Climate and Global Change (i.e. water abstractions). Irrigation water abstractions are very well represented by WaterGAP3 and lie within the range of reported values. Modelled river discharge also shows a good fit to observed data, whereas phases are in sync but volumes are slightly overestimated. Simulated volumes of the Aral Sea itself are well reflected by the model, though results for the period 1990-2002 are too high. In this study, the Climate Change impacts are much smaller (14%) than the water use impacts (86%) on the shrinkage of the Aral Sea. Finally, an outlook on potential scenario model studies is given, which could analyse the different strategies of mitigation and adaptation of Global Change in the Aral Sea basin.

Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis.

PubMed

Abeylath, Sampath C; Turos, Edward; Dickey, Sonja; Lim, Daniel V

2008-03-01

This report describes the synthesis and evaluation of glycosylated polyacrylate nanoparticles that have covalently-bound antibiotics within their framework. The requisite glycosylated drug monomers were prepared from one of three known antibiotics, an N-sec-butylthio beta-lactam, ciprofloxacin, and a penicillin, by acylation with 3-O-acryloyl-1,2-O-isopropylidene-5,6 bis((chlorosuccinyl)oxy)-d-glucofuranose (7) or 6-O-acetyl-3-O-acryloyl-1,2-O-isopropylidene-5-(chlorosuccinyl)oxy-alpha-d-glucofuranose (10). These acrylated monomers were subjected to emulsion polymerization in a 7:3 (w:w) mixture of butyl acrylate-styrene in the presence of sodium dodecyl sulfate as surfactant (3 weight %) and potassium persulfate as a radical initiator (1 weight %). The resulting nanoparticle emulsions were characterized by dynamic light scattering and found to have similar diameters ( approximately 40 nm) and size distributions to those of our previously studied systems. Microbiological testing showed that the N-sec-butylthio beta-lactam and ciprofloxacin nanoparticles both have powerful in vitro activities against methicillin-resistant Staphylococcus aureus and Bacillus anthracis, while the penicillin-bound nanoparticles have no antimicrobial activity. This indicates the need for matching a suitable antibiotic with the nanoparticle carrier. Overall, the study shows that even relatively large, polar acrylate monomers (MW>1000 amu) can be efficiently incorporated into the nanoparticle matrix by emulsion polymerization, providing opportunities for further advances in nanomedicine.

Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis

PubMed Central

Abeylath, Sampath C.; Turos, Edward; Dickey, Sonja; Limb, Daniel V.

2008-01-01

This report describes the synthesis and evaluation of glycosylated polyacrylate nanoparticles that have covalently-bound antibiotics within their framework. The requisite glycosylated drug monomers were prepared from one of three known antibiotics, an N-sec-butylthio β-lactam, ciprofloxacin, and a penicillin, by acylation with 3-O-acryloyl-1,2-O-isopropylidene-5,6 bis((chlorosuccinyl)oxy)-D-glucofuranose (7) or 6-O-acetyl-3-O-acryloyl-1,2-O-isopropylidene-5-(chlorosuccinyl)oxy-α-D-glucofuranose (10). These acrylated monomers were subjected to emulsion polymerization in a 7:3 (w:w) mixture of butyl acrylate-styrene in the presence of sodium dodecyl sulfate as surfactant (3 weight %) and potassium persulfate as a radical initiator (1 weight %). The resulting nanoparticle emulsions were characterized by dynamic light scattering and found to have similar diameters (~40 nm) and size distributions to those of our previously studied systems. Microbiological testing showed that the N-sec-butylthio β-lactam and ciprofloxacin nanoparticles both have powerful in vitro activities against methicillin-resistant Staphylococcus aureus and Bacillus anthracis, while the penicillin-bound nanoparticles have no antimicrobial activity. This indicates the need for matching a suitable antibiotic with the nanoparticle carrier. Overall, the study shows that even relatively large, polar acrylate monomers (MW>1000 amu) can be efficiently incorporated into the nanoparticle matrix by emulsion polymerization, providing opportunities for further advances in nanomedicine. PMID:18063370

The isotopic composition of cosmic ray calcium

NASA Technical Reports Server (NTRS)

Krombel, K. E.; Wiedenbeck, M. E.

1985-01-01

Data from the high energy cosmic ray experiment on the international sun earth explorer 3 (ISEE-3) spacecraft have been used to study the isotopic composition of cosmic ray calcium at an energy of approx. 260 MeV/amu. The arriving calcium is found to consist of (32 + or - 6)%. A propagation model consistent with both the light and the subiron secondary element abundances was used for the interpretation of the observed calcium composition. The measured 42Ca+43Ca+44Ca abundance is consistent with the calculated secondary production, while the 40Ca abundance implies a source ratio of 40Ca/Fe = (7.0 + or - 1.7)%.

The method of space-time and conservation element and solution element: A new approach for solving the Navier-Stokes and Euler equations

NASA Technical Reports Server (NTRS)

Chang, Sin-Chung

1995-01-01

A new numerical framework for solving conservation laws is being developed. This new framework differs substantially in both concept and methodology from the well-established methods, i.e., finite difference, finite volume, finite element, and spectral methods. It is conceptually simple and designed to overcome several key limitations of the above traditional methods. A two-level scheme for solving the convection-diffusion equation is constructed and used to illuminate the major differences between the present method and those previously mentioned. This explicit scheme, referred to as the a-mu scheme, has two independent marching variables.

Time-dependent spin-density-functional-theory description of He+-He collisions

NASA Astrophysics Data System (ADS)

Baxter, Matthew; Kirchner, Tom; Engel, Eberhard

2017-09-01

Theoretical total cross-section results for all ionization and capture processes in the He+-He collision system are presented in the approximate impact energy range of 10-1000 keV/amu. Calculations were performed within the framework of time-dependent spin-density functional theory. The Krieger-Li-Iafrate approximation was used to determine an accurate exchange-correlation potential in the exchange-only limit. The results of two models, one where electron translation factors in the orbitals used to calculate the potential are ignored and another where partial electron translation factors are included, are compared with available experimental data as well as a selection of previous theoretical calculations.

Direct pair production in heavy-ion--atom collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anholt, R.; Jakubassa-Amundsen, D.H.; Amundsen, P.A.

1983-02-01

Direct pair production in approx.5-MeV/amu heavy-ion--atom collisions with uranium target atoms is calculated with the plane-wave Born approximation and the semiclassical approximation. Briggs's approximation is used to obtain the electron and positron wave functions. Since pair production involves high momentum transfer q from the moving projectile to the vacuum, use is made of a high-q approximation to greatly simplify the numerical computations. Coulomb deflection of the projectile, the effect of finite nuclear size on the elec- tronic wave functions, and the energy loss by the projectile exciting the pair are all taken into account in these calculations.

The identification of H3S(+) with the ion of mass per charge (m/q) 35 observed in the coma of Comet Halley

NASA Technical Reports Server (NTRS)

Marconi, M. L.; Mendis, D. A.; Korth, A.; Lin, R. P.; Mitchell, D. L.

1990-01-01

A sharp peak in the mass spectrum at 35 amu is observed by the heavy ion analyzer on board the Giotto spacecraft just inside the ionopause. This peak is identified with H3S(+) and it is argued that the dominant source of its likely parent molecule (H2S) is the observed distributed source of circumnuclear dust, rather than the central nucleus. In this case, the total production rate of H2S is more than about 0.5 percent that of the dominant cometary molecule H2O.

EDITSPEC: Basic Procedures Manual,

DTIC Science & Technology

1981-11-15

0 ag 0 6 s a ~ m.0~~ 0. uj u2 cc 200 , 50 M. - 3- *-a 0. a "a . OC 0aU b-, 00 6. c v a am u ascU Amu soa- o o ’. ~ *ac ~ ~ . i.ac 6*~~~ ~ .0 A0s c...8217 ’,z +a’ . -ll v .0 •%d* go J e mJ.,.bfJ .. 6. . . O ~ ~ ~ 6 A ,, 0i uu2 jA b. OZa U q r. -a 3 U Ua 2 1 a e g g g U ~ u ~ .1H .- a.i h Ag ;I I W

In Situ Plasma Measurements of Fragmented Comet 73P Schwassmann-Wachmann 3

NASA Astrophysics Data System (ADS)

Gilbert, J. A.; Lepri, S. T.; Rubin, M.; Combi, M.; Zurbuchen, T. H.

2015-12-01

The interiors of comets contain some of the most pristine material in the solar system. Comet 73P/Schwassmann-Wachmann 3, discovered in 1930, is a Jupiter-family comet with a 5.34-year period. This comet split into 5 fragments in 1995 and disintegrated into nearly 70 major pieces in 2006. In 2006 May and June, recently ionized cometary particles originating from fragments including and surrounding some of these major objects were collected with the ACE/SWICS and Wind/STICS sensors. Due to a combination of the instrument characteristics and the close proximity of the fragments passing between those spacecraft and the Sun, unique measurements regarding the charge state composition and the elemental abundances of both cometary and heliospheric plasma were made during that time. The cometary material released from some of these fragments can be identified by the concentrations of water-group pickup ions having a mass-per-charge ratio of 16-18 amu e-1, indicating that while these fragments are small, they are still actively sublimating. We present an analysis of cometary composition, spatial distribution, and heliospheric interactions, with a focus on helium, C+/O+, and water-group ions.

IN SITU PLASMA MEASUREMENTS OF FRAGMENTED COMET 73P SCHWASSMANN–WACHMANN 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilbert, J. A.; Lepri, S. T.; Combi, M.

2015-12-10

The interiors of comets contain some of the most pristine material in the solar system. Comet 73P/Schwassmann–Wachmann 3, discovered in 1930, is a Jupiter-family comet with a 5.34-year period. This comet split into 5 fragments in 1995 and disintegrated into nearly 70 major pieces in 2006. In 2006 May and June, recently ionized cometary particles originating from fragments including and surrounding some of these major objects were collected with the ACE/SWICS and Wind/STICS sensors. Due to a combination of the instrument characteristics and the close proximity of the fragments passing between those spacecraft and the Sun, unique measurements regarding themore » charge state composition and the elemental abundances of both cometary and heliospheric plasma were made during that time. The cometary material released from some of these fragments can be identified by the concentrations of water-group pickup ions having a mass-per-charge ratio of 16–18 amu e{sup −1}, indicating that while these fragments are small, they are still actively sublimating. We present an analysis of cometary composition, spatial distribution, and heliospheric interactions, with a focus on helium, C{sup +}/O{sup +}, and water-group ions.« less

The origin of shallow lakes in the Khorezm Province, Uzbekistan, and the history of pesticide use around these lakes

USGS Publications Warehouse

Rosen, Michael R.; Crootof, Arica; Reidy, Liam; Saito, Laurel; Nishonov, Bakhriddin; Scott, Julian A.

2018-01-01

The economy of the Khorezm Province in Uzbekistan relies on the large-scale agricultural production of cotton. To sustain their staple crop, water from the Amu Darya is diverted for irrigation through canal systems constructed during the early to mid-twentieth century when this region was part of the Soviet Union. These diversions severely reduce river flow to the Aral Sea. The Province has >400 small shallow (<3 m deep) lakes that may have originated because of this intensive irrigation. Sediment cores were collected from 12 lakes to elucidate their origin because this knowledge is critical to understanding water use in Khorezm. Core chronological data indicate that the majority of the lakes investigated are less than 150 years old, which supports a recent origin of the lakes. The thickness of lacustrine sediments in the cores analyzed ranged from 20 to 60 cm in all but two of the lakes, indicating a relatively slow sedimentation rate and a relatively short-term history for the lakes. Hydrologic changes in the lakes are evident from loss on ignition and pollen analyses of a subset of the lake cores. The data indicate that the lakes have transitioned from a dry, saline, arid landscape during pre-lake conditions (low organic carbon content) and low pollen concentrations (in the basal sediments) to the current freshwater lakes (high organic content), with abundant freshwater pollen taxa over the last 50–70 years. Sediments at the base of the cores contain pollen taxa dominated by Chenopodiaceae and Tamarix, indicating that the vegetation growing nearby was tolerant to arid saline conditions. The near surface sediments of the cores are dominated by Typha/Sparganium, which indicate freshwater conditions. Increases in pollen of weeds and crop plants indicate an intensification of agricultural activities since the 1950s in the watersheds of the lakes analyzed. Pesticide profiles of DDT (dichlorodiphenyltrichloroethane) and its degradates and γ-HCH (gamma-hexachlorocyclohexane), which were used during the Soviet era, show peak concentrations in the top 10 cm of some of the cores, where estimated ages of the sediments (1950–1990) are associated with peak pesticide use during the Soviet era. These data indicate that the lakes are relatively young (mostly <150 years old) and that without irrigation and canal inputs from the Amu Darya, the lakes would not exist as freshwater lakes.

A Meso-Climatology Study of the High-Resolution Tower Network Over the Florida Spaceport

NASA Technical Reports Server (NTRS)

Case, Jonathan L.; Bauman, William H., III

2004-01-01

Forecasters at the US Air Force 45th Weather Squadron (45 WS) use wind and temperature data from the tower network over the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS) to evaluate Launch Commit Criteria and to issue and verify temperature and wind advisories, watches, and warnings for ground operations. The Spaceflight Meteorology Group at the Johnson Space Center in Houston, TX also uses these data when issuing forecasts for shuttle landings at the KSC Shuttle Landing Facility. Systematic biases in these parameters at any of the towers could adversely affect an analysis, forecast, or verification for all of these operations. In addition, substantial geographical variations in temperature and wind speed can occur under specific wind directions. Therefore, the Applied Meteorology Unit (AMU), operated by ENSCO Inc., was tasked to develop a monthly and hourly climatology of temperatures and winds from the tower network, and identify the geographical variation, tower biases, and the magnitude of those biases. This paper presents a sub-set of results from a nine-year climatology of the KSC/CCAFS tower network, highlighting the geographical variations based on location, month, times of day, and specific wind direction regime. Section 2 provides a description of the tower mesonetwork and instrumentation characteristics. Section 3 presents the methodology used to construct the tower climatology including QC methods and data processing. The results of the tower climatology are presented in Section 4 and Section 5 summarizes the paper.

Report on the Radar/PIREP Cloud Top Discrepancy Study

NASA Technical Reports Server (NTRS)

Wheeler, Mark M.

1997-01-01

This report documents the results of the Applied Meteorology Unit's (AMU) investigation of inconsistencies between pilot reported cloud top heights and weather radar indicated echo top heights (assumed to be cloud tops) as identified by the 45 Weather Squadron (45WS). The objective for this study is to document and understand the differences in echo top characteristics as displayed on both the WSR-88D and WSR-74C radars and cloud top heights reported by the contract weather aircraft in support of space launch operations at Cape Canaveral Air Station (CCAS), Florida. These inconsistencies are of operational concern since various Launch Commit Criteria (LCC) and Flight Rules (FR) in part describe safe and unsafe conditions as a function of cloud thickness. Some background radar information was presented. Scan strategies for the WSR-74C and WSR-88D were reviewed along with a description of normal radar beam propagation influenced by the Effective Earth Radius Model. Atmospheric conditions prior to and leading up to both launch operations were detailed. Through the analysis of rawinsonde and radar data, atmospheric refraction or bending of the radar beam was identified as the cause of the discrepancies between reported cloud top heights by the contract weather aircraft and those as identified by both radars. The atmospheric refraction caused the radar beam to be further bent toward the Earth than normal. This radar beam bending causes the radar target to be displayed erroneously, with higher cloud top heights and a very blocky or skewed appearance.

High-precision Ru isotopic measurements by multi-collector ICP-MS.

PubMed

Becker, Harry; Dalpe, Claude; Walker, Richard J

2002-06-01

Ruthenium isotopic data for a pure Aldrich ruthenium nitrate solution obtained using a Nu Plasma multi collector inductively coupled plasma-mass spectrometer (MC-ICP-MS) shows excellent agreement (better than 1 epsilon unit = 1 part in 10(4)) with data obtained by other techniques for the mass range between 96 and 101 amu. External precisions are at the 0.5-1.7 epsilon level (2sigma). Higher sensitivity for MC ICP-MS compared to negative thermal ionization mass spectrometry (N-TIMS) is offset by the uncertainties introduced by relatively large mass discrimination and instabilities in the plasma source-ion extraction region that affect the long-term reproducibility. Large mass bias correction in ICP mass spectrometry demands particular attention to be paid to the choice of normalizing isotopes. Because of its position in the mass spectrum and the large mass bias correction, obtaining precise and accurate abundance data for 104Ru by MC-ICP-MS remains difficult. Internal and external mass bias correction schemes in this mass range may show similar shortcomings if the isotope of interest does not lie within the mass range covered by the masses used for normalization. Analyses of meteorite samples show that if isobaric interferences from Mo are sufficiently large (Ru/Mo < 10(4)), uncertainties on the Mo interference correction propagate through the mass bias correction and yield inaccurate results for Ru isotopic compositions. Second-order linear corrections may be used to correct for these inaccuracies, but such results are generally less precise than N-TIMS data.

Mass spectrometry of cis-diamminedichloroplatinum(II) adducts with the dinucleosidemonophosphates d(ApG), d(GpG) and d(TpC) in an ion trap.

PubMed

Hagemeister, Timo; Linscheid, Michael

2002-07-01

The detection and fragmentation behaviour of adducts of the chemotherapeutic cis-diamminedichloroplatinum(II) (cisplatin) with the dinucleosidemonophosphates d(ApG), d(GpG) and d(TpC) as model compounds for DNA adducts in an ion trap with electrospray ionization were studied. Mainly the monofunctional adduct, the bifunctional adduct and the bifunctional adduct with platinum bridging two dinucleosidemonophosphates were detected. In addition, several more complex adducts were seen resulting from reactions among these species. Adduct formation was low in the case of d(TpC). Fragmentation could be controlled strongly by varying the temperature of the transfer capillary; furthermore, tandem mass spectrometric (MS/MS) experiments on both the monofunctional and the bifunctional adducts were performed. For the adducts of d(ApG) and d(GpG) losses of NH(3) and HCl were the most dominant reactions, followed by the losses of one, then another two units of 98 amu from the sugar-phosphate backbone, whereas d(TpC)-Pt predominantly forms the dinucleosidemonophosphate. In the gas phase, the conversion of the monofunctional into the bifunctional adducts through binding to another site in the dinucleotide accompanied by loss of NH(3) or HCl could also be observed. The removal of a ligand from the coordination sphere of the square-planar platinum complexes appeared to be the crucial step for the induction of further fragmentation of the dinucleotide ligand. MS(n) experiments of the bifunctional adducts of d(ApG) and d(GpG) revealed different fragmentation pathways involving the loss of phosphoric acid, metaphosphoric acid, deoxyribose units (intact or dehydrated) and the nucleobases in different orders, leaving characteristic binding site-determining fragments. Fragmentation of these ions was also performed, mainly resulting in fragmentation of the bases. The study confirmed the remarkable stability of the platinum-guanine bond compared with other nucleobases. Copyright 2002 John Wiley & Sons, Ltd.

An Operational Configuration of the ARPS Data Analysis System to Initialize WRF in the NM'S Environmental Modeling System

NASA Technical Reports Server (NTRS)

Case, Jonathan; Blottman, Pete; Hoeth, Brian; Oram, Timothy

2006-01-01

The Weather Research and Forecasting (WRF) model is the next generation community mesoscale model designed to enhance collaboration between the research and operational sectors. The NM'S as a whole has begun a transition toward WRF as the mesoscale model of choice to use as a tool in making local forecasts. Currently, both the National Weather Service in Melbourne, FL (NWS MLB) and the Spaceflight Meteorology Group (SMG) are running the Advanced Regional Prediction System (AIRPS) Data Analysis System (ADAS) every 15 minutes over the Florida peninsula to produce high-resolution diagnostics supporting their daily operations. In addition, the NWS MLB and SMG have used ADAS to provide initial conditions for short-range forecasts from the ARPS numerical weather prediction (NWP) model. Both NM'S MLB and SMG have derived great benefit from the maturity of ADAS, and would like to use ADAS for providing initial conditions to WRF. In order to assist in this WRF transition effort, the Applied Meteorology Unit (AMU) was tasked to configure and implement an operational version of WRF that uses output from ADAS for the model initial conditions. Both agencies asked the AMU to develop a framework that allows the ADAS initial conditions to be incorporated into the WRF Environmental Modeling System (EMS) software. Developed by the NM'S Science Operations Officer (S00) Science and Training Resource Center (STRC), the EMS is a complete, full physics, NWP package that incorporates dynamical cores from both the National Center for Atmospheric Research's Advanced Research WRF (ARW) and the National Centers for Environmental Prediction's Non-Hydrostatic Mesoscale Model (NMM) into a single end-to-end forecasting system. The EMS performs nearly all pre- and postprocessing and can be run automatically to obtain external grid data for WRF boundary conditions, run the model, and convert the data into a format that can be readily viewed within the Advanced Weather Interactive Processing System. The EMS has also incorporated the WRF Standard Initialization (SI) graphical user interface (GUT), which allows the user to set up the domain, dynamical core, resolution, etc., with ease. In addition to the SI GUT, the EMS contains a number of configuration files with extensive documentation to help the user select the appropriate input parameters for model physics schemes, integration timesteps, etc. Therefore, because of its streamlined capability, it is quite advantageous to configure ADAS to provide initial condition data to the EMS software. One of the biggest potential benefits of configuring ADAS for ingest into the EMS is that the analyses could be used to initialize either the ARW or NMM. Currently, the ARPS/ADAS software has a conversion routine only for the ARW dynamical core. However, since the NIvIM runs about 2.5 times faster than the ARW, it is quite advantageous to be able to run an ADAS/NMM configuration operationally due to the increased efficiency.

Light Isotope Abundances in Solar Energetic Particles Measured by the NINA-2 Instrument

NASA Astrophysics Data System (ADS)

Mikhailov, V. V.; Bakaldin, A.; Galper, A.; Koldashov, S.; Korotkov, M.; Leonov, A.; Mikhaylova, J.; Voronov, S.; Bidoli, V.; Casolino, M.; De Pascale, M.; Furano, G.; Iannucci, A.; Morselli, A.; Picozza, P.; Sparvoli, R.; Boezio, M.; Bonvicini, V.; Vacchi, A.; Zampa, N.; Ambriola, M.; Bellotti, R.; Cafagna, F.; Circella, M.; De Marzo, C.; Adriani, O.; Papini, P.; Spillantini, P.; Straulino, S.; Vannuccini, E.; Ricci, M.; Castellini, G.

2003-07-01

The instrument NINA-2 flew on board the satellite MITA between July 2000 and August 2001, in circular polar orbit. This paper reports about a set of Solar Energetic Particle events measured by the NINA-2 instrument. The detector has mass resolution of about 0.15 amu for light nuclei and gives the possibility to observe hydrogen and helium isotop es in the energy range 10-50 MeV/n. Data of 3 He and 4 He were used to determine the 3 He/4 He ratio. For each event the deuterium-to-proton ratio was also estimated. This ratio, averaged over all events, is less than 3×10-5 .

Isotope mass fractionation during evaporation of Mg2SiO4

NASA Technical Reports Server (NTRS)

Davis, Andrew M.; Clayton, Robert N.; Mayeda, Toshiko K.; Hashimoto, Akihiko

1990-01-01

Synthetic forsterite (Mg2SiO4) was partially evaporated in vacuum for various durations and at different temperatures. The residual charges obtained when molten Mg2SiO4 was evaporated to 12 percent of its initial mass were enriched in heavy isotopes by about 20, 30, and 15 per mil/amu for O, Mg, and Si, respectively, whereas solid forsterite evaporated to a similar residual mass fraction showed negligible fractionations. These results imply that calcium and aluminum-rich refractory inclusions in carbonaceous chondrites must have been at least partially molten in the primordial solar nebula if the observed large mass fractionation effects were caused by evaporation processes in the nebula.

Inference of the angular velocity of plasma in the Jovian magnetosphere from the sweepback of magnetic field

NASA Technical Reports Server (NTRS)

Khurana, Krishan K.; Kivelson, Margaret G.

1993-01-01

The averaged angular velocity of plasma from magnetic observations is evaluated using plasma outflow rate as a parameter. New techniques are developed to calculate the normal and azimuthal components of the magnetic field in and near to the plasma sheet in a plasma sheet coordinate system. The revised field components differ substantially from the quantities used in previous analyses. With the revised field values, it appears that during the Voyager 2 flyby for an outflow rate of 2.5 x 10 exp 29 amu/s, the observed magnetic torque may be sufficient to keep the plasma in corotation to radial distances of 50 Rj in the postmidnight quadrant.

Neutron-rich isotope production using the uranium carbide multi-foil SPES target prototype

NASA Astrophysics Data System (ADS)

Scarpa, D.; Biasetto, L.; Corradetti, S.; Manzolaro, M.; Andrighetto, A.; Carturan, S.; Prete, G.; Zanonato, P.; Stracener, D. W.

2011-03-01

In the framework of the R&D program for the SPES (Selective Production of Exotic Species) project of the Istituto Nazionale di Fisica Nucleare (INFN), production yields of neutron-rich isotopes have been measured at the Holifield Radioactive Ion Beam Facility (HRIBF, Oak Ridge National Laboratory, USA). This experiment makes use of the multi-foil SPES target prototype composed of 7 uranium carbide discs, with excess of graphite (ratio C/ U = 4 . 77 isotopes of medium mass (between 72 and 141amu), produced via proton-induced fission of uranium using a 40MeV proton beam, have been collected and analyzed for the target heated at 2000 ° C target temperature.

[An experimental study of the susceptibility of the snakehead Ophiocephalus argus to infestation by larvae of the tapeworm Diphyllobothrium latum].

PubMed

Khodakova, V I; Zholdasova, I M; Allaniiazova, T; Frolova, A A; Artamoshin, A S; Guseva, L N; Arystanov, E; Gitsu, G A

1998-01-01

Experiments were made to infect young Ophiocephalus argus, the fish of prey delivered from eastern Asia in the Amu-Dar'ya River basin, outside the area of the broad tapeworm Diphyllobothrium latum. The dalags were infected mainly by ingesting the local copepods Arctodiaptomus salinus, the experimentally invaded larvae of the broad tapeworm. The latter larvae were obtained from the development of eggs of the helminth isolated from strobilae from the patients treated in Perm Province. D. latum plerocercoids lived in the dalags nearly 3 weeks, then they died and lysed. Thus, the dalag cannot be a supplementary host of D. latum.

Time-of-flight mass spectrometry of laser exploding foil initiated PETN samples

NASA Astrophysics Data System (ADS)

Fajardo, Mario E.; Molek, Christopher D.; Fossum, Emily C.

2017-01-01

We report the results of time-of-flight mass spectrometry (TOFMS) measurements of the gaseous products of thin-film pentaerythritol tetranitrate [PETN, C(CH2NO3)4] samples reacting in vacuo. The PETN sample spots are produced by masked physical vapor deposition [A.S. Tappan, et al., AIP Conf. Proc. 1426, 677 (2012)] onto a first-surface aluminum mirror. A pulsed laser beam imaged through the soda lime glass mirror substrate converts the aluminum layer into a high-temperature high-pressure plasma which initiates chemical reactions in the overlying PETN sample. We had previously proposed [E.C. Fossum, et al., AIP Conf. Proc. 1426, 235 (2012)] to exploit differences in gaseous product chemical identities and molecular velocities to provide a chemically-based diagnostic for distinguishing between "detonation-like" and deflagration responses. Briefly: we expect in-vacuum detonations to produce hyperthermal (v˜10 km/s) thermodynamically-stable products such as N2, CO2, and H2O, and for deflagrations to produce mostly reaction intermediates, such as NO and NO2, with much slower molecular velocities - consistent with the expansion-quenched thermal decomposition of PETN. We observe primarily slow reaction intermediates (NO2, CH2NO3) at low laser pulse energies, the appearance of NO at intermediate laser pulse energies, and the appearance of hyperthemal CO/N2 at mass 28 amu at the highest laser pulse energies. However, these results are somewhat ambiguous, as the NO, NO2, and CH2NO3 intermediates persist and all species become hyperthermal at the higher laser pulse energies. Also, the purported CO/N2 signal at 28 amu may be contaminated by silicon ablated from the glass mirror substrate. We plan to mitigate these problems in future experiments by adopting the "Buelow" sample configuration which employs an intermediate foil barrier to shield the energetic material from the laser and the laser driven plasma [S.J. Buelow, et al., AIP Conf. Proc. 706, 1377 (2003)].

Tropical Greenhouse Measurements of Volatile Organic Compounds Using Switchable Reagent Ion Proton-Transfer-Reaction Time-of-Flight Mass Spectromety (PTR-TOF-MS)

NASA Astrophysics Data System (ADS)

Veres, P.; Auld, J.; Williams, J.

2012-04-01

In this presentation, we will summarize the results of measurements made in an approximately 1300 m3 tropical greenhouse at the Johannes Gutenberg University botanical garden in Mainz Germany conducted over a one month period. The greenhouse is home to a large variety of plant species from hot and humid regions of the world. The greenhouse is also host to several crops such as Cocoa and Cola Nut as well as ornamental plants. A particular focus of the species maintained are those which are considered ant plants, or plants which have an intimate relationship with ants in tropical habitats. Volatile organic compounds (VOCs) were measured using a Switchable Reagent Ion Proton-Transfer-Reaction Time-of-Flight Mass Spectrometer (PTR-TOF-MS) using H3O+, NO+, and O2+ ion chemistry. Measurements will be presented both for primary emissions observed in the closed greenhouse atmosphere as well as the oxidation products observed after the introduction of ambient ozone. The high resolving power (5000 m/Δm) of the time-of-flight instrument allows for the separation of isobaric species. In particular, both isoprene (68.1170 amu) and furan (68.0740 amu) were observed and separated as primary emissions during this study. The significance of this will be discussed in terms of both atmospheric implications as well as with respect to previous measurements of isoprene obtained using quadrupole PTR-MS where isobaric separation of these compounds is not possible. Additionally observed species (e.g. Methanol, Acetaldehyde, MVK and MEK) will be discussed in detail with respect to their behavior as a function of light, temperature and relative humidity. The overall instrument performance of the PTR-TOF-MS technique using the H3O+, NO+, and O2+ primary ions for the measurement of VOCs will be evaluated.

The Mushroom: A half-sky energetic ion and electron detector

NASA Astrophysics Data System (ADS)

Hill, M. E.; Mitchell, D. G.; Andrews, G. B.; Cooper, S. A.; Gurnee, R. S.; Hayes, J. R.; Layman, R. S.; McNutt, R. L.; Nelson, K. S.; Parker, C. W.; Schlemm, C. E.; Stokes, M. R.; Begley, S. M.; Boyle, M. P.; Burgum, J. M.; Do, D. H.; Dupont, A. R.; Gold, R. E.; Haggerty, D. K.; Hoffer, E. M.; Hutcheson, J. C.; Jaskulek, S. E.; Krimigis, S. M.; Liang, S. X.; London, S. M.; Noble, M. W.; Roelof, E. C.; Seifert, H.; Strohbehn, K.; Vandegriff, J. D.; Westlake, J. H.

2017-02-01

We present a time-of-flight mass spectrometer design for the measurement of ions in the 30 keV to 10 MeV range for protons (up to 40 MeV and 150 MeV for He and heavy ions, respectively) and 30 keV to 1 MeV range for electrons, covering half of the sky with 80 apertures. The instrument, known as the "Mushroom," owing to its shape, solves the field of view problem for magnetospheric and heliospheric missions that employ three-axis stabilized spacecraft, yet still require extended angular coverage; the Mushroom is also compatible with a spinning spacecraft. The most important new feature of the Mushroom is the method through which uncomplicated electrostatic optics and clean position sensing combine to permit many apertures to fit into a compact, low-mass sensor head (or wedge), several of which (ideally eight) compose a full instrument. Most of the sensor head's volume is an empty, equipotential region, resulting in the modest 250 g mass of each 10-aperture wedge. The Mushroom is capable of separating ion species across most of its energy range and angular field of view. For example, separation of the neighboring 3He and 4He isotopes is excellent; the full width at half maximum mass resolution has been measured to be 0.24 amu to 0.32 amu, respectively. Converting this to a Gaussian width σm in mass m, this represents a σm/m mass resolution better than 0.04. This separation is highly desirable for the flight program for which the first Mushroom was built, the Solar Probe Plus mission. More generally, we estimate the mass resolution to be σm/m ≈ 0.1, but this is energy, mass, and angularly dependent. We also discuss the solid-state detector stack capability, which extends the energy range of protons and helium, with composition, to 100 MeV.

Holocene River Dynamics, Climate Change and Floodwater Farming in the Watersheds of the Pamir and Tien Shan Mountains of Inner Asia

NASA Astrophysics Data System (ADS)

Macklin, M. G.; Panyushkina, I. P.; Toonen, W. H. J.

2014-12-01

The Ili, Syr Dayra and Amu Dayra rivers of Inner Asia are emerging as critical areas for the development of irrigation-based agriculture in the ancient world. Following research by Russian archaeologists in the 1970s it is evident that these watersheds had flourishing riverine civilizations comparable to those in Mesopotamia and the Indus Valley. But unlike these areas where the relationship between Holocene river dynamics, climate change and floodwater farming is increasingly underpinned by radiometric dating, the alluvial archaeology of Inner Asia is significantly under researched. To address this, a major multi-disciplinary research program was begun in 2011 centred on the Talgar catchment, a south-bank tributary of the Ili river, southeast Kazakhstan. Building on archaeological excavations and surveys conducted over the past 20 years, we have undertaken one of the most detailed investigations of Holocene people-river environment interactions in Inner Asia. River development has been reconstructed over the last 20,000 years and human settlement histories from the Eneolithic to the Medieval period documented. Periods of Holocene river aggradation and high water levels in Lake Balkhash and Aral Sea correspond with cooler and wetter neoglacial episodes while river entrenchment and floodplain soil development are associated with warmer and drier conditions. Floodwater farming in the Talgar river reached its acme in the late Iron Age (400-200 cal. BC) with more than 60 settlement sites and 550 burial mounds. This corresponds to a period of reduced flood flows, river stability and glacier retreat in the Tien Shan headwaters. A new hydroclimatic-based model for the spatial and temporal dynamics of floodwater farming in the Ili, Syr Dayra and Amu Dayra watersheds is proposed, which explains the large scale expansion (down-river) and contraction (up-river) of settlements since the first use of irrigation in the Neolithic through to the late Medieval period.

Observation of fullerenes (C60-C70) associated with LDEF crater number 31

NASA Technical Reports Server (NTRS)

Radicatidibrozolo, Filippo; Fleming, R. H.; Bunch, T. E.

1992-01-01

The presence of fullerenes in and around the LDEF crater number 31 is reported. This crater has a high C level associated with it, and is interpreted as having been produced by the impact of a C-rich micrometeoroid. Fullerenes are large 3-D C structures, among which the species C sub 60 (MW 720) and C sub 70 (MW 840) are preeminent. Fullerenes have several UV absorption bands, hence fullerenes should be detectable using UV laser ionization time-of-flight mass spectrometry. We use a LIMA-2A instrument with pulsed UV laser (266 nm) to search for high mass C species associated with LDEF crater number 31. The mass range was 0 to 1200 amu. Low ablating laser power levels were used (less than or = 5 x 10 exp 7 W/sq. cm); 200 mass spectra were acquired and summed. We observed high mass signals near m/z 720, exhibiting 24 amu separation, which is characteristic of fullerenes. Alkali ion signals were also observed. Little or no C clusters of intermediate mass were observed. We interpret the signals around m/z 720 as fullerenes, mainly C sub 60+ with lower levels of C sub 70+. We propose that the mechanism that produces these signals is resonant multiphoton ionization (REMPI). This selective mechanism explains why low mass C cluster ions are not observed along with the fullerenes, since they have much higher ionization potentials. This finding is unexpected, since up to now the search for fullerenes in extraterrestrial materials has not been successful. We conclude that the fullerenes became associated with crater number 31 in space. Two alternative (and exciting) scenarios are being considered at this time: either the fullerenes were carried by the C-rich projectile that formed crater number 31, or the fullerenes formed upon impact with the LDEF. We show the results of experiments at the ARC Vertical Gun Facility, which may establish some constraints on the origin of the fullerenes.

Earth Observations taken by the Expedition 15 Crew

NASA Image and Video Library

2007-05-12

ISS015-E-07874 (12 May 2007) --- A major dust storm (center right) along the east side of the Aral Sea, Kazakhstan, is featured in this image photographed by an Expedition 15 crewmember on the International Space Station while passing over central Asia. The white, irregular lines along the bottom of the image are salt and clay deposits on the present coastline. On the spring day when the ISS crew shot the image, winds were blowing from the west (lower left). The gray, puffy appearance is typical of dust clouds, allowing scientists to distinguish dust from fog and smog. The dust in this image is rising from the sea bed of the Aral Sea, from a point close to the middle of the original Aral Sea of 40--50 years ago, then the fourth largest inland sea on Earth. Heavy extraction of water from the main supply river, the Amu Dary'a, has resulted in rapid shrinking of the sea. According to scientists, dust storms have been occurring in the Aral Sea region for thousands of years, but since the drastic shrinking of the sea over the past half-century an important change in dust composition has occurred. The dust now includes fertilizer and pesticide washed into the Sea from the extensive cotton fields of the Amu Dary'a floodplain. Years of liberal application of agricultural chemicals have resulted in concentration of these pollutants on the sea bed. These are now exposed to the wind and transported hundreds of kilometers in a generally easterly direction. Research suggests that the remobilized chemicals are the cause of high rates of many diseases in the populations along the north, east and southern margins of the Aral Sea. This is one of the unintended consequences of the shrinking of the sea, which has made international news for many years due to the loss of the fishing industry and other significant ecological problems.

Geometrical and gravimetrical observations of the Aral Sea and its tributaries along with hydrological models

NASA Astrophysics Data System (ADS)

Singh, A.; Seitz, F.; Schwatke, C.; Güntner, A.

2012-04-01

Satellite altimetry is capable of measuring surface water level changes of large water bodies. This is especially interesting for regions where in-situ gauges are sparse or not available. Temporal variations of coastline and horizontal extent of a water body can be derived from optical remote sensing data. A joint analysis of both data types together with a digital elevation model allows for the estimation of water volume changes. Related variations of water mass map into the observations of the satellite gravity field mission GRACE. In this presentation, we demonstrate the application of heterogeneuous remote sensing methods for studying chages of water volume and mass of the Aral Sea and compare the results with respect to their consistency. Our analysis covers the period 2002-2011. In particular we deal with data from multi-mission radar and laser satellite altimetry that are analyzed in combination with coastlines from Landsat images. The resultant vertical and horizontal variations of the lake surface are geometrically intersected with the bathymetry of the Aral Sea in order to compute volumetric changes. These are transformed into variations of water mass that are subsequently compared with storage changes derived from GRACE satellite gravimetry. Hence we obtain a comprehensive picture of the hydrological changes in the region. Observations from all datasets correspond quite well with each other with respect to their temporal development. However, geometrically determined volume changes and mass changes observed by GRACE agree less well during years of heavy water inflow in to the Aral Sea from its southern tributary 'Amu Darya' since the GRACE signals are contaminated by the large mass of water stored in the river delta and prearalie region On the other hand, GRACE observations of the river basins of Syr Darya and Amu Dayra correspond very well with hydrological models and mass changes computed from the balance of precipitation, evaporation and runoff determined from the atmospheric-terrestrial water balance.

Finite field equation of Yang--Mills theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brandt, R.A.; Wing-Chiu, N.; Yeung, W.

1980-03-01

We consider the finite local field equation -)(1+1/..cap alpha.. (1+f/sub 4/))g/sup munu/D'Alembertian-partial/sup ..mu../partial/sup ..nu../)A/sup nua/ =-(1+f/sub 3/) g/sup 2/N(A/sup c/..nu..A/sup a/..mu..A/sub ..nu..//sup c/) +xxx+(1-s)/sup 2/M/sup 2/A/sup a/..mu.., introduced by Lowenstein to rigorously describe SU(2) Yang--Mills theory, which is written in terms of normal products. We also consider the operator product expansion A/sup c/..nu..(x+xi) A/sup a/..mu..(x) A/sup b/lambda(x-xi) approx...sigma..M/sup c/ab..nu mu..lambda/sub c/'a'b'..nu..'..mu..'lambda' (xi) N(A/sup nuprimec/'A/sup muprimea/'A/sup lambdaprimeb/')(x), and using asymptotic freedom, we compute the leading behavior of the Wilson coefficients M/sup ...//sub .../(xi) with the help of a computer, and express the normal products in the field equation in terms ofmore » products of the c-number Wilson coefficients and of operator products like A/sup c/..nu..(x+xi) A/sup a/..mu..(x) A/sup b/lambda(x-xi) at separated points. Our result is -)(1+(1/..cap alpha..)(1+f/sub 4/))g/sup munu/D'Alembertian-partial/sup ..mu../partial/sup ..nu../)A/sup nua/ =-(1+f/sub 3/) g/sup 2/lim/sub xiarrow-right0/) (lnxi)/sup -0.28/2b/(A/sup c/..nu.. (x+xi) A/sup a/..mu..(x) A/sub ..nu..//sup c/(x-xi) +epsilon/sup a/bcA/sup muc/(x+xi) partial/sup ..nu../A/sup b//sub ..nu../(x)+xxx) +xxx)+(1-s)/sup 2/M/sup 2/A/sup a/..mu.., where ..beta.. (g) =-bg/sup 3/, and so (lnxi)/sup -0.28/2b/ is the leading behavior of the c-number coefficient multiplying the operator products in the field equation.« less

Ion cyclotron waves near comet C/2013 A1 (Siding Spring) and Mars

NASA Astrophysics Data System (ADS)

Crary, F. J.; Dols, V. J.; Connerney, J. E. P.; Espley, J. R.

2014-12-01

On October 19, 2014, comet C/2013 A1 (Siding Spring) passed approximately 135,000 km from Mars. Previously,we predicted the amplitude of ion cyclotron waves which might be observed during the Siding Spring encounter. Ioncyclotron waves have been observed both in the vicinity of comets and of Mars. These waves are generated by theionization of neutrals in the flowing solar wind, which produces an unstable ring-beam velocity distribution. We estimated that, for a production rate of 2x1028 s-1, ion cyclotron wave with amplitudes over 0.1 nT would be present within ‡5 hours (1.2 million km) of closest approach. We will compare the actual observations made by the MAVEN spacecraft with these predictions. The spacecraft was close to or downstream of the martian bow shock, which complicates the interpretation of the data. Taking thisinto account, we will describe the observations and their implications for wave activity and cometary neutral production. We also present updated hybrid simulations of ion cyclotron wave generation. The simulations use our best estimate of solar wind conditions at the time of the encounter and a variable injection of 18 AMU pickup ions, at a rates consistent a model of the cometary neutrals.

Purification of a myotoxin from the toadfish Thalassophryne maculosa (Günter) venom.

PubMed

Sosa-Rosales, J I; D'Suze, G; Salazar, V; Fox, J; Sevcik, C

2005-02-01

Venom was milked by gently pressing the base of the opercular and dorsal fin spines. Three fractions were obtained by molecular exclusion high pressure liquid chromatography (HPLC) (Protein Pak 125SW, Millipore Corporation) column, but only the last one with 22.7 min retention time (rt) was biological active (TmPP-22.7). This fraction was rechromatographed on reversed phase HPLC chlorobutylsilane columns (C4, Vydac) nine fractions were obtained, but only one (TmC4-47.2) with 47.2 min rt was biologically active. MALD-TOF mass analysis was carried out on two samples of TmC-47.2 and the results were 15,161.36 and 15,154.70 a.m.u., respectively. Raw venom (1040 microg/ml) depolarised frog (Hyla crepitans) muscle irreversibly from -85 (-88, -81) mV (n=20, median and its 95% CI) to -18 (-24, -15) mV (n=24). The biological activity in TmPP-22.7 (38 microg/ml), which depolarised muscle fibres from -79 (-82, -76) mV (n=20) to -63 (-69 -57) mV (n=24). The depolarising fraction was TmC4-47.2 (50 microg/ml) which depolarised muscles from -87 (91, -82) mV (n=33) to -63 (-76 -51) mV (n=53); the depolarising effect at this concentration was completely reversed on washing with normal saline for 2 h. Muscles treated with 1 microM tetrodotoxin (TTX) were depolarised from -80 (-85, -72) mV (n=49) to -44 (-56, -31) mV (n=44) when 100 microg/ml TmC4-47.2 were applied with TTX; washing 130 min with 1 microM TTX repolarised to -59 (-69, -50) mV (n=25). We also present evidence that TmC4-47.2 induces myonecrosis in mice.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collister, R.; Gwinner, G.; Tandecki, M.

We present the isotope shifts of the 7s 1/2 to 7p 1/2 transition for francium isotopes ²⁰⁶⁻²¹³Fr with reference to ²²¹Fr collected from two experimental periods. The shifts are measured on a sample of atoms prepared within a magneto-optical trap by a fast sweep of radio-frequency sidebands applied to a carrier laser. King plot analysis, which includes literature values for 7s 1/2 to 7p 3/2 isotope shifts, provides a field shift constant ratio of 1.0520(10) and a difference between the specific mass shift constants of 170(100) GHz amu between the D₁ and D₂ transitions, of sufficient precision to differentiate betweenmore » ab initio calculations.« less

Negative ion formation in potassium-nitromethane collisions.

PubMed

Antunes, R; Almeida, D; Martins, G; Mason, N J; Garcia, G; Maneira, M J P; Nunes, Y; Limão-Vieira, P

2010-10-21

Ion-pair formation in gaseous nitromethane (CH(3)NO(2)) induced by electron transfer has been studied by investigating the products of collisions between fast potassium atoms and nitromethane molecules using a crossed molecular-beam technique. The negative ions formed in such collisions were analysed using time-of-flight mass spectroscopy. The six most dominant product anions are NO(2)(-), O(-), CH(3)NO(2)(-), OH(-), CH(2)NO(2)(-) and CNO(-). By using nitromethane-d(3) (CD(3)NO(2)), we found that previous mass 17 amu assignment to O(-) delayed fragment, is in the present experiment may be unambiguously assigned to OH(-). The formation of CH(2)NO(2)(-) may be explained in terms of dissociative electron attachment to highly vibrationally excited molecules.

Search for Stable Strange Quark Matter in Lunar Soil

NASA Astrophysics Data System (ADS)

Han, K.; Ashenfelter, J.; Chikanian, A.; Emmet, W.; Finch, L. E.; Heinz, A.; Madsen, J.; Majka, R. D.; Monreal, B.; Sandweiss, J.

2009-08-01

We report results from a search for strangelets (small chunks of strange quark matter) in lunar soil using the Yale WNSL accelerator as a mass spectrometer. We have searched over a range in mass from A=42 to A=70amu for nuclear charges 5, 6, 8, 9, and 11. No strangelets were found in the experiment. For strangelets with nuclear charge 8, a concentration in lunar soil higher than 10-16 is excluded at the 95% confidence level. The implied limit on the strangelet flux in cosmic rays is the most sensitive to date for the covered range and is relevant to both recent theoretical flux predictions and a strangelet candidate event found by the AMS-01 experiment.

A particle astrophysics magnet facility: ASTROMAG

NASA Technical Reports Server (NTRS)

Ormes, Jonathan F. (Editor); Israel, Martin H. (Editor); Mewaldt, Richard A. (Editor); Wiedenbeck, Mark E. (Editor)

1988-01-01

The primary scientific objectives of ASTROMAG are to: examine cosmological models by searching for antimatter and dark matter candidates; study the origin and evolution of matter in the galaxy by direct sampling of galactic matter; and study the origin and acceleration of the relativistic particle plasma in the galaxy and its effects on the dynamics and evolution of the galaxy. These general scientific objectives will be met by ASTROMAG with particle detection instruments designed to make the following observations: search, for anti-nuclei of helium and heavier element; measure the spectra of anti-protons and positrons; measure the isotopic composition of cosmic ray nuclei at energies of several GeV/amu; and measure the energy spectra of cosmic ray nuclei to very high energies.

Report of the Aircraft Systems/Flight Test Workshop (1979) Aircraft Engineering Division, Systems and Flight Test Branches, held October 2 - 10, 1979, NASA/AMES Research Center, Moffett Field, CA

DTIC Science & Technology

1979-10-10

intercept the ILS at Allegheny County. The outside air temperature was +60 at 3000 feet. It was possible to perform the ILS approach within one dot...stMatr wW lrve of the Aru paca roferomd -L Zt* AMU taliax. JAM4 0. E8DLMSM cc: P-13Ol/13iA/1O/203/200/g-21-O/23/C-E’Ifl-4 no 0Ai3 ..c /2 .89 AGENDA ITEM...to intercept the ILS at Allegheny County. The outside air temperature was +60 at 3000 feet. It was possible to perform the ILS approach within one dot

STS-2, -3, -4 Induced Environment Contamination Monitor (ICEM)

NASA Technical Reports Server (NTRS)

Miller, E. R. (Editor)

1983-01-01

The second, third, and fourth space transportation system missions are described including the location of the IECM in the payload bay and the shuttle coordinate systems used. Measurement results from the three flights are given for each instrument with comparisons to original goals for preflight environment and induced environment contamination. These results include very low levels of molecular mass accumulation rates, absence of molecular films on optical samples, outgassing species above 50 amu undetectable generally low levels of on-orbit particulates, and decay rates for early mission water dump particulates. Results of exposure of several optical materials and coatings to atomic oxygen are also presented. From these results, it is concluded that the space shuttle met the established induced environment contamination goals.

Beam production of a laser ion source with a rotating hollow cylinder target for low energy positive and negative ions

NASA Astrophysics Data System (ADS)

Saquilayan, G. Q.; Wada, M.

2017-08-01

A laser ion source that utilizes a hollow cylinder target is being developed for the production of positive and negative ions. Continuous operation of the laser ion source is possible through the design of a rotating target. Ion extraction through a grounded circular aperture was tested for positive and negative ions up to 1 kV. Time-of-flight measurements for the mass separation of ions were made by placing a Faraday cup at locations 0 and 15 mm from the beam extraction axis. Signals corresponding to slow and massive ions were detected with mass at least 380 amu. Investigation on the beam profile suggests a geometrical optimization of the beam forming system is necessary.

Forecasting Lightning at Kennedy Space Center/Cape Canaveral Air Force Station, Florida

NASA Technical Reports Server (NTRS)

Lambert, Winfred; Wheeler, Mark; Roeder, William

2005-01-01

The Applied Meteorology Unit (AMU) developed a set of statistical forecast equations that provide a probability of lightning occurrence on Kennedy Space Center (KSC) I Cape Canaveral Air Force Station (CCAFS) for the day during the warm season (May September). The 45th Weather Squadron (45 WS) forecasters at CCAFS in Florida include a probability of lightning occurrence in their daily 24-hour and weekly planning forecasts, which are briefed at 1100 UTC (0700 EDT). This information is used for general scheduling of operations at CCAFS and KSC. Forecasters at the Spaceflight Meteorology Group also make thunderstorm forecasts for the KSC/CCAFS area during Shuttle flight operations. Much of the current lightning probability forecast at both groups is based on a subjective analysis of model and observational data. The objective tool currently available is the Neumann-Pfeffer Thunderstorm Index (NPTI, Neumann 1971), developed specifically for the KSCICCAFS area over 30 years ago. However, recent studies have shown that 1-day persistence provides a better forecast than the NPTI, indicating that the NPTI needed to be upgraded or replaced. Because they require a tool that provides a reliable estimate of the daily thunderstorm probability forecast, the 45 WS forecasters requested that the AMU develop a new lightning probability forecast tool using recent data and more sophisticated techniques now possible through more computing power than that available over 30 years ago. The equation development incorporated results from two research projects that investigated causes of lightning occurrence near KSCICCAFS and over the Florida peninsula. One proved that logistic regression outperformed the linear regression method used in NPTI, even when the same predictors were used. The other study found relationships between large scale flow regimes and spatial lightning distributions over Florida. Lightning, probabilities based on these flow regimes were used as candidate predictors in the equation development. Fifteen years (1 989-2003) of warm season data were used to develop the forecast equations. The data sources included a local network of cloud-to-ground lightning sensors called the Cloud-to-Ground Lightning Surveillance System (CGLSS), 1200 UTC Florida synoptic soundings, and the 1000 UTC CCAFS sounding. Data from CGLSS were used to determine lightning occurrence for each day. The 1200 UTC soundings were used to calculate the synoptic-scale flow regimes and the 1000 UTC soundings were used to calculate local stability parameters, which were used as candidate predictors of lightning occurrence. Five logistic regression forecast equations were created through careful selection and elimination of the candidate predictors. The resulting equations contain five to six predictors each. Results from four performance tests indicated that the equations showed an increase in skill over several standard forecasting methods, good reliability, an ability to distinguish between non-lightning and lightning days, and good accuracy measures and skill scores. Given the overall good performance the 45 WS requested that the equations be transitioned to operations and added to the current set of tools used to determine the daily lightning probability of occurrence.

Stopping of relativistic heavy ions in various media

NASA Technical Reports Server (NTRS)

Waddington, C. J.; Fixsen, D. J.; Crawford, H. J.; Lindstrom, P. J.; Heckman, H. H.

1986-01-01

The residual ranges of (900 + or - 3)-MeV/amu gold nuclei accelerated at the Lawrence Berkeley Laboratory Bevalac have been measured in several different media. The energy of the beam of nuclei was measured directly using a new time-of-flight system. The ranges were measured by absorption in linear wedges of polyethylene, carbon, aluminum, copper, tin, and lead and in circular wedges of polystyrene, aluminum, and gold, and by total absorption in nuclear emulsion. The measured ranges were significantly different from those calculated from the best available theoretical estimates of the energy loss of highly charged nuclei. It is concluded that at present energy losses and residual ranges of relativistic heavy ions in an arbitrary medium cannot be predicted with better than an approximately 2 percent accuracy.

Elemental abundances of cosmic rays with Z 33 as measured on HEAO-3

NASA Technical Reports Server (NTRS)

Newport, B. J.; Stone, E. C.; Waddington, C. J.; Binns, W. R.; Garrard, T. L.; Israel, M. H.; Klarmann, J.

1985-01-01

The Heavy Nuclei Experiment on (HEAO-3) high energy astronomy observatory 3 uses a combination of ion chambers and a Cerenkov counter. During analysis, each particle is assigned two parameters, Z sub c and Z sub i, proportional to the square roots of the Cerenkov and mean ionization signals respectively. Because the ionization signal is double valued, a unique assignment of particle charge, Z, is not possible in general. Previous work was limited to particles of either high rigidity or low energy, for which a unique charge assignment was possible, although those subsets contain less than 50% of the total number of particles observed. The maximum likelihood technique was used to determine abundances for the complete data set from approx. 1.5 to approx. 80 GeV/amu.

Isotope shifts in francium isotopes Fr 206 - 213 and Fr 221

DOE PAGES

Collister, R.; Gwinner, G.; Tandecki, M.; ...

2014-11-07

We present the isotope shifts of the 7s 1/2 to 7p 1/2 transition for francium isotopes ²⁰⁶⁻²¹³Fr with reference to ²²¹Fr collected from two experimental periods. The shifts are measured on a sample of atoms prepared within a magneto-optical trap by a fast sweep of radio-frequency sidebands applied to a carrier laser. King plot analysis, which includes literature values for 7s 1/2 to 7p 3/2 isotope shifts, provides a field shift constant ratio of 1.0520(10) and a difference between the specific mass shift constants of 170(100) GHz amu between the D₁ and D₂ transitions, of sufficient precision to differentiate betweenmore » ab initio calculations.« less

Secondary electrons induced by fast ions under channeling conditions. II. Screening of fast heavy ions in solids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kudo, H.; Shima, K.; Seki, S.

1991-06-01

Ion-beam shadowing effects have been observed for secondary electrons induced by various ions in the energy range of 1.8--3.8 MeV/amu, under various channeling conditions in Si and GaAs crystals. From a comparison of the energy spectra of electrons induced by ions of equal velocity, we have found reduced shadowing effects for heavy ions (Si, S, and Cl) as compared with light (H, He, C, and O) ions. It is concluded that the reduction results from the screening of the heavy ion's nuclear charge by bound electrons. By analyzing the reduced shadowing effect, the effective nuclear charges for the heavy ionsmore » within the target crystals have been determined.« less

Material Outgassing, Identification and Deposition, MOLIDEP System

NASA Technical Reports Server (NTRS)

Scialdone, John J.; Montoya, Alex F.

2002-01-01

The outgassing tests are performed employing a modified vacuum operated Cahn analytical microbalance, identified as the MOLIDEP system. The test measures under high vacuum, the time varying Molecular mass loss of a material sample held at a chosen temperature; it Identifies the outgassing molecular components using an inline SRS 300 amu Residual Gas Analyzer (RGA) and employs a temperature controlled 10 MHz Quartz Crystal Microbalance (QCM) to measure the condensable DEPosits. Both the QCM and the RGA intercept within the conductive passage the outgassing products being evacuated by a turbomolecular pump. The continuous measurements of the mass loss, the rate of loss, the sample temperature, the rate of temperature change, the QCM temperature and the QCM recorded condensable deposits or rate of deposits are saved to an Excel spreadsheet. A separate computer controls the RGA.

Sputtering of sulfur by kiloelectronvolt ions - Application to the magnetospheric plasma interaction with Io

NASA Technical Reports Server (NTRS)

Chrisey, D. B.; Johnson, R. E.; Phipps, J. A.; Mcgrath, M. A.; Boring, J. W.

1987-01-01

Accurate measurements of the yields, mass spectra, and energy spectra of ejected sulfur are presented based on vapor deposits of sulfur at temperatures and ion energies relevant to the plasma interaction with the surface of Io. The measured sputtering yields are much lower than previous estimates for room temperature sulfur films, but are comparable to previous measurements of low-temperature keV ion sputtering of SO2. Results suggest that if ions reach the surface of Io its atmosphere will have a nonnegligible sulfur component which is primarily S2. Comparison of injection rates determined for sulfur with those for SO2 indicates that injection from sulfur deposits contributes 13 percent to the total mass injection rate of about 2-3 x 10 to the 29th amu/sec.

NASA Weather Support 2017

NASA Technical Reports Server (NTRS)

Carroll, Matt

2017-01-01

In the mid to late 1980's, as NASA was studying ways to improve weather forecasting capabilities to reduce excessive weather launch delays and to reduce excessive weather Launch Commit Criteria (LCC) waivers, the Challenger Accident occurred and the AC-67 Mishap occurred.[1] NASA and USAF weather personnel had advance knowledge of extremely high levels of weather hazards that ultimately caused or contributed to both of these accidents. In both cases, key knowledge of the risks posed by violations of weather LCC was not in the possession of final decision makers on the launch teams. In addition to convening the mishap boards for these two lost missions, NASA convened expert meteorological boards focusing on weather support. These meteorological boards recommended the development of a dedicated organization with the highest levels of weather expertise and influence to support all of American spaceflight. NASA immediately established the Weather Support Office (WSO) in the Office of Space Flight (OSF), and in coordination with the United Stated Air Force (USAF), initiated an overhaul of the organization and an improvement in technology used for weather support as recommended. Soon after, the USAF established a senior civilian Launch Weather Officer (LWO) position to provide meteorological support and continuity of weather expertise and knowledge over time. The Applied Meteorology Unit (AMU) was established by NASA, USAF, and the National Weather Service to support initiatives to place new tools and methods into an operational status. At the end of the Shuttle Program, after several weather office reorganizations, the WSO function had been assigned to a weather branch at Kennedy Space Center (KSC). This branch was dismantled in steps due to further reorganization, loss of key personnel, and loss of budget line authority. NASA is facing the loss of sufficient expertise and leadership required to provide current levels of weather support. The recommendation proposed herein is to re-establish the WSO under a high level office, with funding set at about the same levels as today, with a revitalized charter and focus to allow for the WSO to operate as originally intended.

PTR-QMS versus PTR-TOF comparison in a region with oil and natural gas extraction industry in the Uintah Basin in 2013

NASA Astrophysics Data System (ADS)

Warneke, C.; Veres, P.; Murphy, S. M.; Soltis, J.; Field, R. A.; Graus, M. G.; Koss, A.; Li, S.-M.; Li, R.; Yuan, B.; Roberts, J. M.; de Gouw, J. A.

2015-01-01

Here we compare volatile organic compound (VOC) measurements using a standard proton-transfer-reaction quadrupole mass spectrometer (PTR-QMS) with a new proton-transfer-reaction time of flight mass spectrometer (PTR-TOF) during the Uintah Basin Winter Ozone Study 2013 (UBWOS2013) field experiment in an oil and gas field in the Uintah Basin, Utah. The PTR-QMS uses a quadrupole, which is a mass filter that lets one mass to charge ratio pass at a time, whereas the PTR-TOF uses a time of flight mass spectrometer, which takes full mass spectra with typical 0.1 s-1 min integrated acquisition times. The sensitivity of the PTR-QMS in units of counts per ppbv (parts per billion by volume) is about a factor of 10-35 times larger than the PTR-TOF, when only one VOC is measured. The sensitivity of the PTR-TOF is mass dependent because of the mass discrimination caused by the sampling duty cycle in the orthogonal-acceleration region of the TOF. For example, the PTR-QMS on mass 33 (methanol) is 35 times more sensitive than the PTR-TOF and for masses above 120 amu less than 10 times more. If more than 10-35 compounds are measured with PTR-QMS, the sampling time per ion decreases and the PTR-TOF has higher signals per unit measuring time for most masses. For UBWOS2013 the PTR-QMS measured 34 masses in 37 s and on that timescale the PTR-TOF is more sensitive for all masses. The high mass resolution of the TOF allows for the measurements of compounds that cannot be separately detected with the PTR-QMS, such as oxidation products from alkanes and cycloalkanes emitted by oil and gas extraction. PTR-TOF masses do not have to be preselected, allowing for identification of unanticipated compounds. The measured mixing ratios of the two instruments agreed very well (R2 ≥ 0.92 and within 20%) for all compounds and masses monitored with the PTR-QMS.

PTR-QMS vs. PTR-TOF comparison in a region with oil and natural gas extraction industry in the Uintah Basin in 2013

NASA Astrophysics Data System (ADS)

Warneke, C.; Veres, P. R.; Murphy, S. M.; Soltis, J.; Field, R. A.; Graus, M. G.; Koss, A.; Li, S.-M.; Li, R.; Yuan, B.; Roberts, J. M.; de Gouw, J. A.

2014-07-01

Here we compare volatile organic compound (VOC) measurements using a standard Proton-Transfer-Reaction Quadrupole Mass Spectrometer (PTR-QMS) with a new Proton-Transfer-Reaction Time Of Flight Mass Spectrometer (PTR-TOF) during the Uintah Basin Winter Ozone Study 2013 (UBWOS2013) field experiment in an oil and gas field in the Uintah Basin, Utah. The PTR-QMS uses a quadrupole, which is a mass filter that lets one mass pass at a time, whereas the PTR-TOF uses a Time Of Flight mass spectrometer, which takes full mass spectra with typical 0.1 s to 1 min integrated acquisition times. The sensitivity of the PTR-QMS in units of counts per ppbv is about a factor of 10-35 times larger than the PTR-TOF, when only one VOC is measured. The sensitivity of the PTR-TOF is mass dependent because of the mass discrimination caused by the sampling duty cycle in the orthogonal-acceleration region of the TOF. For example, the PTR-QMS on mass 33 (methanol) is 35 times more sensitive than the PTR-TOF and for masses above 120 amu less than 10 times more. If more than 10-35 compounds are measured with PTR-QMS, the sampling time per ion decreases and the PTR-TOF has higher signals per unit measuring time for most masses. For UBWOS2013 the PTR-QMS measured 34 masses in 37 s and on that time-scale the PTR-TOF is more sensitive for all masses. The high mass resolution of the TOF allows for the measurements of compounds that cannot be separately detected with the PTR-QMS, such as oxidation products from alkanes and cycloalkanes emitted by oil and gas extraction. PTR-TOF masses do not have to be pre-selected allowing for identification of unanticipated compounds. The measured mixing ratios of the two instruments agreed very well (R2 ≥ 0.92 and within 20%) for all compounds and masses monitored with the PTR-QMS.

Identification of nitrogen sources to four small lakes in the agricultural region of Khorezm, Uzbekistan

USGS Publications Warehouse

Shanafield, M.; Rosen, M.; Saito, L.; Chandra, S.; Lamers, J.; Nishonov, Bakhriddin

2010-01-01

Pollution of inland waters by agricultural land use is a concern in many areas of the world, and especially in arid regions, where water resources are inherently scarce. This study used physical and chemical water quality and stable nitrogen isotope (δ15N) measurements from zooplankton to examine nitrogen (N) sources and concentrations in four small lakes of Khorezm, Uzbekistan, an arid, highly agricultural region, which is part of the environmentally-impacted Aral Sea Basin. During the 2-year study period, ammonium concentrations were the highest dissolved inorganic N species in all lakes, with a maximum of 3.00 mg N l−1 and an average concentration of 0.62 mg N l−1. Nitrate levels were low, with a maximum concentration of 0.46 mg N l−1 and an average of 0.05 mg N l−1 for all four lakes. The limited zooplankton δ15N values did not correlate with the high loads of synthetic fertilizer applied to local croplands during summer months. These results suggest that the N cycles in these lakes may be more influenced by regional dynamics than agricultural activity in the immediate surroundings. The Amu-Darya River, which provides the main source of irrigation water to the region, was identified as a possible source of the primary N input to the lakes.

Verify MesoNAM Performance

NASA Technical Reports Server (NTRS)

Bauman, William H., III

2010-01-01

The AMU conducted an objective analysis of the MesoNAM forecasts compared to observed values from sensors at specified KSC/CCAFS wind towers by calculating the following statistics to verify the performance of the model: 1) Bias (mean difference), 2) Standard deviation of Bias, 3) Root Mean Square Error (RMSE), and 4) Hypothesis test for Bias = O. The 45 WS LWOs use the MesoNAM to support launch weather operations. However, the actual performance of the model at KSC and CCAFS had not been measured objectively. The analysis compared the MesoNAM forecast winds, temperature and dew point to the observed values from the sensors on wind towers. The data were stratified by tower sensor, month and onshore/offshore wind direction based on the orientation of the coastline to each tower's location. The model's performance statistics were then calculated for each wind tower based on sensor height and model initialization time. The period of record for the data used in this task was based on the operational start of the current MesoNAM in mid-August 2006 and so the task began with the first full month of data, September 2006, through May 2010. The analysis of model performance indicated: a) The accuracy decreased as the forecast valid time from the model initialization increased, b) There was a diurnal signal in T with a cool bias during the late night and a warm bias during the afternoon, c) There was a diurnal signal in Td with a low bias during the afternoon and a high bias during the late night, and d) The model parameters at each vertical level most closely matched the observed parameters at heights closest to those vertical levels. The AMU developed a GUI that consists of a multi-level drop-down menu written in JavaScript embedded within the HTML code. This tool allows the LWO to easily and efficiently navigate among the charts and spreadsheet files containing the model performance statistics. The objective statistics give the LWOs knowledge of the model's strengths and weaknesses and the GUI allows quick access to the data which will result in improved forecasts for operations.

Shrinking Aral Sea

NASA Image and Video Library

2017-12-08

(Aral Sea: left 2014 and right 2000, 1960 extent black line) In the 1960s, the Soviet Union undertook a major water diversion project on the arid plains of Kazakhstan, Uzbekistan, and Turkmenistan. The region’s two major rivers, fed by snowmelt and precipitation in faraway mountains, were used to transform the desert into farms for cotton and other crops. Before the project, the Syr Darya and the Amu Darya rivers flowed down from the mountains, cut northwest through the Kyzylkum Desert, and finally pooled together in the lowest part of the basin. The lake they made, the Aral Sea, was once the fourth largest in the world. Although irrigation made the desert bloom, it devastated the Aral Sea. This series of images from the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA’s Terra satellite documents the changes. At the start of the series in 2000, the lake was already a fraction of its 1960 extent (black line). The Northern Aral Sea (sometimes called the Small Aral Sea) had separated from the Southern (Large) Aral Sea. The Southern Aral Sea had split into eastern and western lobes that remained tenuously connected at both ends. By 2001, the southern connection had been severed, and the shallower eastern part retreated rapidly over the next several years. Especially large retreats in the eastern lobe of the Southern Sea appear to have occurred between 2005 and 2009, when drought limited and then cut off the flow of the Amu Darya. Water levels then fluctuated annually between 2009 and 2014 in alternately dry and wet years. Dry conditions in 2014 caused the Southern Sea’s eastern lobe to completely dry up for the first time in modern times. Continue reading: 1.usa.gov/1nLX9Ku Read more: 1.usa.gov/1pqEnDj Credit: NASA Earth Observatory NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Modeling the Vakhsh Cascade in the Amu Darya River Basin - Implementing Future Storage Facilities in a Hydrological Model for Impact Assessment

NASA Astrophysics Data System (ADS)

Steiner, J. F.; Siegfried, T.; Yakovlev, A.

2014-12-01

In the Amu Darya River Basin in Central Asia, the Vakhsh catchment in Tajikistan is a major source of hydropower energy for the country. With a number of large dams already constructed, upstream Tajikistan is interested in the construction of one more large dam and a number of smaller storage facilities with the prospect of supplying its neighboring states with hydropower through a newly planned power grid. The impact of new storage facilities along the river is difficult to estimate and causes considerable concern and consternation among the downstream users. Today, it is one of the vexing poster child studies in international water conflict that awaits resolution. With a lack of meteorological data and a complex topography that makes application of remote sensed data difficult it is a challenge to model runoff correctly. Large parts of the catchment is glacierized and ranges from just 500 m asl to peaks above 7000 m asl. Based on in-situ time series for temperature and precipitation we find local correction factors for remote sensed products. Using this data we employ a model based on the Budyko framework with an extension for snow and ice in the higher altitude bands. The model furthermore accounts for groundwater and soil storage. Runoff data from a number of stations are used for the calibration of the model parameters. With an accurate representation of the existing and planned reservoirs in the Vakhsh cascade we study the potential impacts from the construction of the new large reservoir in the river. Impacts are measured in terms of a) the timing and availability of new hydropower energy, also in light of its potential for export to South Asia, b) shifting challenges with regard to river sediment loads and siltation of reservoirs and c) impacts on downstream runoff and the timely availability of irrigation water there. With our coupled hydro-climatological approach, the challenges of optimal cascade management can be addressed so as to minimize detrimental impacts on all sides if runoff forecast information at seasonal scales is taken into account for optimal operational multi-storage management.

White matter atlas of the human spinal cord with estimation of partial volume effect.

PubMed

Lévy, S; Benhamou, M; Naaman, C; Rainville, P; Callot, V; Cohen-Adad, J

2015-10-01

Template-based analysis has proven to be an efficient, objective and reproducible way of extracting relevant information from multi-parametric MRI data. Using common atlases, it is possible to quantify MRI metrics within specific regions without the need for manual segmentation. This method is therefore free from user-bias and amenable to group studies. While template-based analysis is common procedure for the brain, there is currently no atlas of the white matter (WM) spinal pathways. The goals of this study were: (i) to create an atlas of the white matter tracts compatible with the MNI-Poly-AMU template and (ii) to propose methods to quantify metrics within the atlas that account for partial volume effect. The WM atlas was generated by: (i) digitalizing an existing WM atlas from a well-known source (Gray's Anatomy), (ii) registering this atlas to the MNI-Poly-AMU template at the corresponding slice (C4 vertebral level), (iii) propagating the atlas throughout all slices of the template (C1 to T6) using regularized diffeomorphic transformations and (iv) computing partial volume values for each voxel and each tract. Several approaches were implemented and validated to quantify metrics within the atlas, including weighted-average and Gaussian mixture models. Proof-of-concept application was done in five subjects for quantifying magnetization transfer ratio (MTR) in each tract of the atlas. The resulting WM atlas showed consistent topological organization and smooth transitions along the rostro-caudal axis. The median MTR across tracts was 26.2. Significant differences were detected across tracts, vertebral levels and subjects, but not across laterality (right-left). Among the different tested approaches to extract metrics, the maximum a posteriori showed highest performance with respect to noise, inter-tract variability, tract size and partial volume effect. This new WM atlas of the human spinal cord overcomes the biases associated with manual delineation and partial volume effect. Combined with multi-parametric data, the atlas can be applied to study demyelination and degeneration in diseases such as multiple sclerosis and will facilitate the conduction of longitudinal and multi-center studies. Copyright © 2015 Elsevier Inc. All rights reserved.

An Analysis of Peak Wind Speed Data from Collocated Mechanical and Ultrasonic Anemometers

NASA Technical Reports Server (NTRS)

Short, David A.; Wells, Leonard A.; Merceret, Francis J.; Roeder, William P.

2005-01-01

This study focuses on a comparison of peak wind speeds reported by mechanical and ultrasonic anemometers at Cape Canaveral Air Force Station and Kennedy Space Center (CCAFS/KSC) on the east central coast of Florida and Vandenberg Air Force Base (VAFB) on the central coast of California. The legacy mechanical wind instruments on CCAFS/KSC and VAFB weather towers are being changed from propeller-and-vane (CCAFS/KSC) and cup-and-vane (VAFB) sensors to ultrasonic sensors under the Range Standardization and Automation (RSA) program. The wind tower networks on KSC/CCAFS and VAFB have 41 and 27 towers, respectively. Launch Weather Officers, forecasters, and Range Safety analysts at both locations need to understand the performance of the new wind sensors for a myriad of reasons that include weather warnings, watches, advisories, special ground processing operations, launch pad exposure forecasts, user Launch Commit Criteria (LCC) forecasts and evaluations, and toxic dispersion support. The Legacy sensors measure wind speed and direction mechanically. The ultrasonic RSA sensors have no moving parts. Ultrasonic sensors were originally developed to measure very light winds (Lewis and Dover 2004). The technology has evolved and now ultrasonic sensors provide reliable wind data over a broad range of wind speeds. However, because ultrasonic sensors respond more quickly than mechanical sensors to rapid fluctuations in speed, characteristic of gusty wind conditions, comparisons of data from the two sensor types have shown differences in the statistics of peak wind speeds (Lewis and Dover 2004). The 45th Weather Squadron (45 WS) and the 30 WS requested the Applied Meteorology Unit (AMU) to compare data from RSA and Legacy sensors to determine if there are significant differences in peak wind speed information from the two systems.

Determination of eugenol, anethole, and coumarin in the mainstream cigarette smoke of Indonesian clove cigarettes.

PubMed

Polzin, Gregory M; Stanfill, Stephen B; Brown, Candace R; Ashley, David L; Watson, Clifford H

2007-10-01

Indonesian clove cigarettes (kreteks), typically have the appearance of a conventional domestic cigarette. The unique aspects of kreteks are that in addition to tobacco they contain dried clove buds (15-40%, by wt.), and are flavored with a proprietary "sauce". Whereas the clove buds contribute to generating high levels of eugenol in the smoke, the "sauce" may also contribute other potentially harmful constituents in addition to those associated with tobacco use. We measured levels of eugenol, trans-anethole (anethole), and coumarin in smoke from 33 brands of clove-flavored cigarettes (filtered and unfiltered) from five kretek manufacturers. In order to provide information for evaluating the delivery of these compounds under standard smoking conditions, a quantification method was developed for their measurement in mainstream cigarette smoke. The method allowed collection of mainstream cigarette smoke particulate matter on a Cambridge filter pad, extraction with methanol, sampling by automated headspace solid-phase microextraction, and subsequent analysis using gas chromatography/mass spectrometry. The presence of these compounds was confirmed in the smoke of kreteks using mass spectral library matching, high-resolution mass spectrometry (+/-0.0002 amu), and agreement with a relative retention time index, and native standards. We found that when kreteks were smoked according to standardized machine smoke parameters as specified by the International Standards Organization, all 33 clove brands contained levels of eugenol ranging from 2,490 to 37,900 microg/cigarette (microg/cig). Anethole was detected in smoke from 13 brands at levels of 22.8-1,030 microg/cig, and coumarin was detected in 19 brands at levels ranging from 9.2 to 215 microg/cig. These detected levels are significantly higher than the levels found in commercial cigarette brands available in the United States.

Consultant Input in Acute Medical Admissions and Patient Outcomes in Hospitals in England: A Multivariate Analysis

PubMed Central

Bell, Derek; Lambourne, Adrian; Percival, Frances; Laverty, Anthony A.; Ward, David K.

2013-01-01

Recent recommendations for physicians in the UK outline key aspects of care that should improve patient outcomes and experience in acute hospital care. Included in these recommendations are Consultant patterns of work to improve timeliness of clinical review and improve continuity of care. This study used a contemporaneous validated survey compared with clinical outcomes derived from Hospital Episode Statistics, between April 2009 and March 2010 from 91 acute hospital sites in England to evaluate systems of consultant cover for acute medical admissions. Clinical outcomes studied included adjusted case fatality rates (aCFR), including the ratio of weekend to weekday mortality, length of stay and readmission rates. Hospitals that had an admitting Consultant presence within the Acute Medicine Unit (AMU, or equivalent) for a minimum of 4 hours per day (65% of study group) had a lower aCFR compared with hospitals that had Consultant presence for less than 4 hours per day (p<0.01) and also had a lower 28 day re-admission rate (p<0.01). An ‘all inclusive’ pattern of Consultant working, incorporating all the guideline recommendations and which included the minimum Consultant presence of 4 hours per day (29%) was associated with reduced excess weekend mortality (p<0.05). Hospitals with >40 acute medical admissions per day had a lower aCFR compared to hospitals with fewer than 40 admissions per day (p<0.03) and had a lower 7 day re-admission rate (p<0.02). This study is the first large study to explore the potential relationships between systems of providing acute medical care and clinical outcomes. The results show an association between well-designed systems of Consultant working practices, which promote increased patient contact, and improved patient outcomes in the acute hospital setting. PMID:23613858

Consultant input in acute medical admissions and patient outcomes in hospitals in England: a multivariate analysis.

PubMed

Bell, Derek; Lambourne, Adrian; Percival, Frances; Laverty, Anthony A; Ward, David K

2013-01-01

Recent recommendations for physicians in the UK outline key aspects of care that should improve patient outcomes and experience in acute hospital care. Included in these recommendations are Consultant patterns of work to improve timeliness of clinical review and improve continuity of care. This study used a contemporaneous validated survey compared with clinical outcomes derived from Hospital Episode Statistics, between April 2009 and March 2010 from 91 acute hospital sites in England to evaluate systems of consultant cover for acute medical admissions. Clinical outcomes studied included adjusted case fatality rates (aCFR), including the ratio of weekend to weekday mortality, length of stay and readmission rates. Hospitals that had an admitting Consultant presence within the Acute Medicine Unit (AMU, or equivalent) for a minimum of 4 hours per day (65% of study group) had a lower aCFR compared with hospitals that had Consultant presence for less than 4 hours per day (p<0.01) and also had a lower 28 day re-admission rate (p<0.01). An 'all inclusive' pattern of Consultant working, incorporating all the guideline recommendations and which included the minimum Consultant presence of 4 hours per day (29%) was associated with reduced excess weekend mortality (p<0.05). Hospitals with >40 acute medical admissions per day had a lower aCFR compared to hospitals with fewer than 40 admissions per day (p<0.03) and had a lower 7 day re-admission rate (p<0.02). This study is the first large study to explore the potential relationships between systems of providing acute medical care and clinical outcomes. The results show an association between well-designed systems of Consultant working practices, which promote increased patient contact, and improved patient outcomes in the acute hospital setting.

Image-based modeling of radiation-induced foci

NASA Astrophysics Data System (ADS)

Costes, Sylvain; Cucinotta, Francis A.; Ponomarev, Artem; Barcellos-Hoff, Mary Helen; Chen, James; Chou, William; Gascard, Philippe

Several proteins involved in the response to DNA double strand breaks (DSB) form microscopically visible nuclear domains, or foci, after exposure to ionizing radiation. Radiation-induced foci (RIF) are believed to be located where DNA damage occurs. To test this assumption, we used Monte Carlo simulations to predict the spatial distribution of DSB in human nuclei exposed to high or low-LET radiation. We then compared these predictions to the distribution patterns of three DNA damage sensing proteins, i.e. 53BP1, phosphorylated ATM and γH2AX in human mammary epithelial. The probability to induce DSB can be derived from DNA fragment data measured experimentally by pulsed-field gel electrophoresis. We first used this probability in Monte Carlo simulations to predict DSB locations in synthetic nuclei geometrically described by a complete set of human chromosomes, taking into account microscope optics from real experiments. Simulations showed a very good agreement for high-LET, predicting 0.7 foci/µm along the path of a 1 GeV/amu Fe particle against measurement of 0.69 to 0.82 foci/µm for various RIF 5 min following exposure (LET 150 keV/µm). On the other hand, discrepancies were shown in foci frequency for low-LET, with measurements 20One drawback using a theoretical model for the nucleus is that it assumes a simplistic and static pattern for DNA densities. However DNA damage pattern is highly correlated to DNA density pattern (i.e. the more DNA, the more likely to have a break). Therefore, we generalized our Monte Carlo approach to real microscope images, assuming pixel intensity of DAPI in the nucleus was directly proportional to the amount of DNA in that pixel. With such approach we could predict DNA damage pattern in real images on a per nucleus basis. Since energy is randomly deposited along high-LET particle paths, RIF along these paths should also be randomly distributed. As expected, simulations produced DNA-weighted random (Poisson) distributions. In contrast, the distributions of RIF obtained as early as 5 min after exposure to high LET (1 GeV/amu Fe) were non-random. This deviation from the expected DNA-weighted random pattern was further characterized by "relative DNA image measurements". This novel imaging approach showed that RIF were located preferentially at the interface between high and low DNA density regions, and were more frequent than predicted in regions with lower DNA density. The same preferential nuclear location was also measured for RIF induced by 1 Gy of low-LET radiation. This deviation from random behavior was evident only 5 min after irradiation for phosphorylated ATM RIF, while γH2AX and 53BP1 RIF showed pronounced deviations up to 30 min after exposure. These data suggest that RIF within a few minutes following exposure to radiation cluster into open regions of the nucleus (i.e. euchromatin). It is possible that DNA lesions are collected in these nuclear sub-domains for more efficient repair. If so, this would imply that DSB are actively transported within the nucleus, a phenomenon that has not yet been considered in modeling DNA misrepair following exposure to radiation. These results are thus critical for more accurate risk models of radiation and we are actively working on characterizing further RIF movement in human nuclei using live cell imaging.

Analysis and application of heavy isotopes in the environment

NASA Astrophysics Data System (ADS)

Steier, Peter; Dellinger, Franz; Forstner, Oliver; Golser, Robin; Knie, Klaus; Kutschera, Walter; Priller, Alfred; Quinto, Francesca; Srncik, Michaela; Terrasi, Filippo; Vockenhuber, Christof; Wallner, Anton; Wallner, Gabriele; Wild, Eva Maria

2010-04-01

A growing number of AMS laboratories are pursuing applications of actinides. We discuss the basic requirements of the AMS technique of heavy (i.e., above ˜150 amu) isotopes, present the setup at the Vienna Environmental Research Accelerator (VERA) which is especially well suited for the isotope 236U, and give a comparison with other AMS facilities. Special emphasis will be put on elaborating the effective detection limits for environmental samples with respect to other mass spectrometric methods. At VERA, we have carried out measurements for radiation protection and environmental monitoring ( 236U, 239,240,241,242,244Pu), astrophysics ( 182Hf, 236U, 244Pu, 247Cm), nuclear physics, and a search for long-lived super-heavy elements ( Z > 100). We are pursuing the environmental distribution of 236U, as a basis for geological applications of natural 236U.

Radiative-emission analysis in charge-exchange collisions of O6 + with argon, water, and methane

NASA Astrophysics Data System (ADS)

Leung, Anthony C. K.; Kirchner, Tom

2017-04-01

Processes of electron capture followed by Auger and radiative decay were investigated in slow ion-atom and -molecule collisions. A quantum-mechanical analysis which utilizes the basis generator method within an independent electron model was carried out for collisions of O 6 + with Ar, H2O , and CH4 at impact energies of 1.17 and 2.33 keV/amu. At these impact energies, a closure approximation in the spectral representation of the Hamiltonian for molecules was found to be necessary to yield reliable results. Total single-, double-, and triple-electron-capture cross sections obtained show good agreement with previous measurements and calculations using the classical trajectory Monte Carlo method. The corresponding emission spectra from single capture for each collision system are in satisfactory agreement with previous calculations.

Method for studying a sample of material using a heavy ion induced mass spectrometer source

DOEpatents

Fries, D.P.; Browning, J.F.

1999-02-16

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu. 3 figs.

Method for studying a sample of material using a heavy ion induced mass spectrometer source

DOEpatents

Fries, David P.; Browning, James F.

1999-01-01

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu.

System for studying a sample of material using a heavy ion induced mass spectrometer source

DOEpatents

Fries, David P.; Browning, James F.

1998-01-01

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu.

System for studying a sample of material using a heavy ion induced mass spectrometer source

DOEpatents

Fries, D.P.; Browning, J.F.

1998-07-21

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high (n,f) reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu. 3 figs.

The neutral mass spectrometer on Dynamics Explorer B

NASA Technical Reports Server (NTRS)

Carignan, G. R.; Block, B. P.; Maurer, J. C.; Hedin, A. E.; Reber, C. A.; Spencer, N. W.

1981-01-01

A neutral gas mass spectrometer has been developed to satisfy the measurement requirements of the Dynamics Explorer mission. The mass spectrometer, a quadrupole, will measure the abundances of neutral species in the region 300-500 km in the earth's atmosphere. These measurements will be used in concert with other simultaneous observations on Dynamics Explorer to study the physical processes involved in the interactions of the magnetosphere-ionosphere-atmosphere system. The instrument, which is similar to that flown on Atmosphere Explorer, employs an electron beam ion source operating in the closed mode and a discrete dynode multiplier as a detector. The mass range is 22 to 50 amu. The abundances of atomic oxygen, molecular nitrogen, helium, argon, and possibly atomic nitrogen will be measured to an accuracy of about + or - 15% over the specified altitude range, with a temporal resolution of one second.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborty, Bipasha; Davies, C. T. H.; de Oliveira, P. G.

We determine the contribution to the anomalous magnetic moment of the muon from themore » $$\\alpha^2_{\\mathrm{QED}}$$ hadronic vacuum polarization diagram using full lattice QCD and including $u/d$ quarks with physical masses for the first time. We use gluon field configurations that include $u$, $d$, $s$ and $c$ quarks in the sea at multiple values of the lattice spacing, multiple $u/d$ masses and multiple volumes that allow us to include an analysis of finite-volume effects. We obtain a result for $$a_{\\mu}^{\\mathrm{HVP,LO}}$$ of $667(6)(12)$, where the first error is from the lattice calculation and the second includes systematic errors from missing QED and isospin-breaking effects and from quark-line disconnected diagrams. Our result implies a discrepancy between the experimental determination of $$a_{\\mu}$$ and the Standard Model of 3$$\\sigma$$.« less

Mars Pathfinder and the exploration of southern Amazonis Planitia

NASA Technical Reports Server (NTRS)

Barlow, Nadine G.

1994-01-01

The southern region of Amazonis Planitia provides a variety of target terrains for a roving vehicle such as the Mars Pathfinder Mission. A landing site is proposed at 4 deg N latitude 162 deg W longitude. This area has a reference altitude of between 0 and -1 km and consists of relatively smooth Amazonian-aged deposits within the entire 100 x 200 km landing ellipse. The proposed landing site is within the Upper Member Medusae Fossae Formation deposits (Amu) and near the boundary with Middle Member Medusae Fossae Formation deposits (Amm) and Member 1 Arcadia Formation plains (Aa(sub 1)). Slightly further afield are 107-km-diameter Nicholson crater, its ejecta deposits, and knobby terrain of proposed Hesperian age (HNu). Depending on the exact landing site of the spacecraft and the traverse distance of the rover, these materials also may be sampled.

Models for Cometary Comae Containing Negative Ions

NASA Technical Reports Server (NTRS)

Cordiner, M. A.; Charnley, S. B.

2012-01-01

The presence of negative ions (anions) in cometary comae is known from Giotto mass spectrometry of IP/Halley. The anions O(-), OH(-), C(-), CH(-) and CN(-) have been detected, as well as unidentified anions with masses 22-65 and 85-110 amu [I]. Organic molecular anions such as C4H(-) and C6H(-) are known to have a significant impact on the charge balance of interstellar clouds and circumstellar envelopes and have been shown to act as catalysts for the gas phase synthesis of larger hydrocarbon molecules in the ISM, but their importance in cometary comae has not yet been fully explored. We present details of our new models for the chemistry of cometary comae that include atomic and molecular anions. We calculate the impact of these anions on the charge balance and examine their importance for cometary coma chemistry.

The He-3/He-4 ratios for solar energetic particle events during the Combined Release and Radiation Effects Satellite Mission

NASA Technical Reports Server (NTRS)

Chen, Jiasheng; Guzik, T. Gregory; Wefel, John P.

1995-01-01

Helium data measured by the University of Chicago instrument, ONR-604, are employed to determine the ratio of He-3 to He-4 for solar energetic particle (SEP) events over an energy range 50-110 MeV/nucleon during the 1990/1991 Combined Release and Radiation Effects Satellite mission. The Sun in this period is extremely active. A total of 29 separate SEP events have been identified; among them 16 major events have been analyzed to obtain He-3/He-4 ratios, with a mass resolution of 0.10 amu. Thirteen events have a He-3/He-4 ratio larger than 0.005, one order of magnitude greater than the solar coronal value. The He-3/He-4 ratio at energies of 50-110 MeV/nucleon is independent of the size of the SEP event, for the moderately large flares analyzed here. The helium energy spectra are represented by power laws. During the 1991 June flare period, different large-particle injections associated with different solar flares, but occurring from the same active region, have a similar average spectral index and a similar He-3/He-4 ratio. The spectral index of He-4 varies from event to event, i.e., from as small as 1.5 to as large as 7.5. A correlation is found between the inferred spectral index from gamma-ray measurements and our measured spectral indices for the 1991 June 11 and June 15 events, suggesting that the high-energy SEPs may come from the same acceleration event as the particles that interact at the Sun and produce the gamma rays. The implications of these results for particle acceleration and propagation at the flare site and in the solar corona are discussed.

Realistic simulations of a cyclotron spiral inflector within a particle-in-cell framework

NASA Astrophysics Data System (ADS)

Winklehner, Daniel; Adelmann, Andreas; Gsell, Achim; Kaman, Tulin; Campo, Daniela

2017-12-01

We present an upgrade to the particle-in-cell ion beam simulation code opal that enables us to run highly realistic simulations of the spiral inflector system of a compact cyclotron. This upgrade includes a new geometry class and field solver that can handle the complicated boundary conditions posed by the electrode system in the central region of the cyclotron both in terms of particle termination, and calculation of self-fields. Results are benchmarked against the analytical solution of a coasting beam. As a practical example, the spiral inflector and the first revolution in a 1 MeV /amu test cyclotron, located at Best Cyclotron Systems, Inc., are modeled and compared to the simulation results. We find that opal can now handle arbitrary boundary geometries with relative ease. Simulated injection efficiencies and beam shape compare well with measured efficiencies and a preliminary measurement of the beam distribution after injection.

Contributions of solar-wind induced potential sputtering to the lunar surface erosion rate and it's exosphere

NASA Astrophysics Data System (ADS)

Alnussirat, S. T.; Barghouty, A. F.; Edmunson, J. E.; Sabra, M. S.; Rickman, D. L.

2018-04-01

Sputtering of lunar regolith by solar-wind protons and heavy ions with kinetic energies of about 1 keV/amu is an important erosive process that affects the lunar surface and exosphere. It plays an important role in changing the chemical composition and thickness of the surface layer, and in introducing material into the exosphere. Kinetic sputtering is well modeled and understood, but understanding of mechanisms of potential sputtering has lagged behind. In this study we differentiate the contributions of potential sputtering from the standard (kinetic) sputtering in changing the chemical composition and erosion rate of the lunar surface. Also we study the contribution of potential sputtering in developing the lunar exosphere. Our results show that potential sputtering enhances the total characteristic sputtering erosion rate by about 44%, and reduces sputtering time scales by the same amount. Potential sputtering also introduces more material into the lunar exosphere.

Gas-phase study on uridine: Conformation and X-ray photofragmentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Itälä, Eero, E-mail: ersita@utu.fi; Kooser, Kuno; Levola, Helena

2015-05-21

Fragmentation of RNA nucleoside uridine, induced by carbon 1s core ionization, has been studied. The measurements by combined electron and ion spectroscopy have been performed in gas phase utilizing synchrotron radiation. As uridine is a combination of d-ribose and uracil, which have been studied earlier with the same method, this study also considers the effect of chemical environment and the relevant functional groups. Furthermore, since in core ionization the initial core hole is always highly localized, charge migration prior to fragmentation has been studied here. This study also demonstrates the destructive nature of core ionization as in most cases themore » C 1s ionization of uridine leads to concerted explosions producing only small fragments with masses ≤43 amu. In addition to fragmentation patterns, we found out that upon evaporation the sugar part of the uridine molecule attains hexagonal form.« less

Avalanche photodiode based time-of-flight mass spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ogasawara, Keiichi, E-mail: kogasawara@swri.edu; Livi, Stefano A.; Desai, Mihir I.

2015-08-15

This study reports on the performance of Avalanche Photodiodes (APDs) as a timing detector for ion Time-of-Flight (TOF) mass spectroscopy. We found that the fast signal carrier speed in a reach-through type APD enables an extremely short timescale response with a mass or energy independent <2 ns rise time for <200 keV ions (1−40 AMU) under proper bias voltage operations. When combined with a microchannel plate to detect start electron signals from an ultra-thin carbon foil, the APD comprises a novel TOF system that successfully operates with a <0.8 ns intrinsic timing resolution even using commercial off-the-shelf constant-fraction discriminators. Bymore » replacing conventional total-energy detectors in the TOF-Energy system, APDs offer significant power and mass savings or an anti-coincidence background rejection capability in future space instrumentation.« less

An instrument employing electronic counters and an emulsion chamber for studying heavy cosmic ray interactions (JACEE-3)

NASA Technical Reports Server (NTRS)

Austin, R. W.; Meegan, C. A.; Parnell, T. A.; Selig, W. J.; Watts, J. W.; Burnett, T. H.; Iwai, J.; Lord, J. J.; Strauscz, S.; Wilkes, R. J.;

Molecular wake shield gas analyzer

NASA Technical Reports Server (NTRS)

Hoffman, J. H.

1980-01-01

Techniques for measuring and characterizing the ultrahigh vacuum in the wake of an orbiting spacecraft are studied. A high sensitivity mass spectrometer that contains a double mass analyzer consisting of an open source miniature magnetic sector field neutral gas analyzer and an identical ion analyzer is proposed. These are configured to detect and identify gas and ion species of hydrogen, helium, nitrogen, oxygen, nitric oxide, and carbon dioxide and any other gas or ion species in the 1 to 46 amu mass range. This range covers the normal atmospheric constituents. The sensitivity of the instrument is sufficient to measure ambient gases and ion with a particle density of the order of one per cc. A chemical pump, or getter, is mounted near the entrance aperture of the neutral gas analyzer which integrates the absorption of ambient gases for a selectable period of time for subsequent release and analysis. The sensitivity is realizable for all but rare gases using this technique.

Theoretical investigation of the electron capture and loss processes in the collisions of He2+ + Ne.

PubMed

Hong, Xuhai; Wang, Feng; Jiao, Yalong; Su, Wenyong; Wang, Jianguo; Gou, Bingcong

2013-08-28

Based on the time-dependent density functional theory, a method is developed to study ion-atom collision dynamics, which self-consistently couples the quantum mechanical description of electron dynamics with the classical treatment of the ion motion. Employing real-time and real-space method, the coordinate space translation technique is introduced to allow one to focus on the region of target or projectile depending on the actual concerned process. The benchmark calculations are performed for the collisions of He(2+) + Ne, and the time evolution of electron density distribution is monitored, which provides interesting details of the interaction dynamics between the electrons and ion cores. The cross sections of single and many electron capture and loss have been calculated in the energy range of 1-1000 keV/amu, and the results show a good agreement with the available experiments over a wide range of impact energies.

Detection of singly ionized energetic lunar pick-up ions upstream of earth's bow shock

NASA Technical Reports Server (NTRS)

Hilchenbach, M.; Hovestadt, D.; Klecker, B.; Moebius, E.

1992-01-01

Singly ionized suprathermal ions upstream of the earth's bow shock have been detected by using the time-of-flight spectrometer SULEICA on the AMPTE/IRM satellite. The data were collected between August and December 1985. The flux of the ions in the mass range between 23 and 37 amu is highly anisotropic towards the earth. The ions are observed with a period of about 29 days around new moon (+/- 3 days). The correlation of the energy of the ions with the solar wind speed and the interplanetary magnetic field orientation indicates the relation to the pick-up process. We conclude that the source of these pick-up ions is the moon. We argue that due to the impinging solar wind, atoms are sputtered off the lunar surface, ionized in the sputtering process or by ensuing photoionization and picked up by the solar wind.

Calibration of a stack of NaI scintillators at the Berkeley Bevalac

NASA Technical Reports Server (NTRS)

Schindler, S. M.; Buffington, A.; Lau, K.; Rasmussen, I. L.

1983-01-01

An analysis of the carbon and argon data reveals that essentially all of the charge-changing fragmentation reactions within the stack can be identified and removed by imposing the simple criteria relating the observed energy deposition profiles to the expected Bragg curve depositions. It is noted that these criteria are even capable of identifying approximately one-third of the expected neutron-stripping interactions, which in these cases have anomalous deposition profiles. The contribution of mass error from uncertainty in delta E has an upper limit of 0.25 percent for Mn; this produces an associated mass error for the experiment of about 0.14 amu. It is believed that this uncertainty will change little with changing gamma. Residual errors in the mapping produce even smaller mass errors for lighter isotopes, whereas photoelectron fluctuations and delta-ray effects are approximately the same independent of the charge and energy deposition.

Quiet-Time Spectra and Abundances of Energetic Particles During the 1996 Solar Minimum

NASA Technical Reports Server (NTRS)

Reames, Donald V.

1999-01-01

We report the energy spectra and abundances of ions with atomic number, Z, in the interval Z is greater than or equal to 2 and Z is less than or equal to 36 and energies approximately 3-20 MeV/amu for solar and interplanetary quiet periods between 1994 November and 1998 April as measured by the large-geometry Low Energy Matrix Telescope (LEMT) telescope on the Wind spacecraft near Earth. The energy spectra show the presence of galactic (GCR) and "anomalous" cosmic ray (ACR) components, depending on the element. ACR components are reported for Mg and Si for the first time at 1 AU and the previous observation of S and Ar is confirmed. However, only GCR components are clearly apparent for the elements Ca, Ti, Cr, Fe, as well as for C. New limits are placed on a possible ACR contribution for other elements, including Kr.

Quiet-Time Spectra and Abundances of Energetic Particles During the 1996 Solar Minimum

NASA Technical Reports Server (NTRS)

Reames, Donald V.

1998-01-01

This report concerns the energy spectra and abundances of ions with atomic number, Z, in the interval 2 greater than or equal to Z and Z less than or equal to 36 and energies approximately 3-20 MeV/amu for solar and interplanetary quiet periods between November 1994 and April 1998 as measured by the large-geometry LEMT telescope on the Wind spacecraft near Earth. The energy spectra show the presence of galactic (GCR) and 'anomalous' cosmic ray (ACR) components, depending on the element. ACR components are reported for Mg and Si for the first time at 1 AU and the previous observation of S and Ar is confirmed. However, only GCR components are clearly apparent for the elements Ca, Ti, Cr, Fe, as well as for C. New limits are placed on a possible ACR contribution for other elements, including Kr.

Mass analysis of neutral particles and ions released during electrical breakdowns on spacecraft surfaces

NASA Technical Reports Server (NTRS)

Kendall, B. R. F.

1983-01-01

A specialized spectrometer was designed and developed to measure the mass and velocity distributions of neutral particles (molecules and molecular clusters) released from metal-backed Teflon and Kapton films. Promising results were obtained with an insulation breakdown initiation system based on a moveable contact touching the insulated surfaces. A variable energy, high voltage pulse is applied to the contact. The resulting surface damage sites can be made similar in size and shape to those produced by a high voltage electron beam system operating at similar discharge energies. The point discharge apparatus was used for final development of several high speed recording systems and for measurements of the composition of the materials given off by the discharge. Results with this apparatus show evolution of large amounts of fluorocarbon fragments from discharge through Teflon FEP, while discharges through Kapton produce mainly very light hydrocarbon fragments at masses below about 80 a.m.u.

A Semiempirical Formula for Single-Electron-Capture Cross Sections of Multiply Charged Ions Colliding with H, H2 and He

NASA Astrophysics Data System (ADS)

Nakai, Yohta; Shirai, Toshizo; Tabata, Tatsuo; Ito, Rinsuke

1989-01-01

A universal analytic formula is given for the total cross sections of single-electron capture by multiply-charged ions colliding with H, H2 or He. Values of constants in the formula have been determined by least-squares fit to experimental data collected from the literature. The formula is applicable to ions of almost all atomic species with charge q greater than 4 (for the H and H2 targets) or 5 (for the He target) in the energy region from about 1 to 107 eV amu-1. The root-mean-square deviation of the data from the formula is 29%. The formula shows that the cross sections are proportional to q1.07 at low energies and to q2.86 at high energies. Other trends of the cross sections that can be derived from the formula are also discussed.

In situ measurements of the photochemical formation rates and optical properties of organic aerosols in CH4/CO2 mixtures.

NASA Astrophysics Data System (ADS)

Adamkovics, M.; Boering, K. A.

2003-12-01

The presence of photochemically-generated hazes has a significant impact on radiative transfer in planetary atmospheres. While the rates of particle formation have been inferred from photochemical or microphysical models constrained to match observations, these rates have not been determined experimentally. Thus, the fundamental kinetics of particle formation are not known and remain highly parameterized in planetary atmospheric models. We have developed instrumentation for measuring the formation rates and optical properties of organic aerosols produced by irradiating mixtures of precursor gases via in situ optical (633nm) scattering and online quadrupole mass spectrometry (1-200 amu). Results for the generation of particulate hydrocarbons from the irradiation of pure, gas-phase CH4 as well as CH4/CO2 mixtures with vacuum ultraviolet (120-160nm) light, along with simultaneous measurements of the evolution of higher gas-phase hydrocarbons will be presented.

Organochlorine pesticides residue in lakes of Khorezm, Uzbekistan

USGS Publications Warehouse

Rosen, Michael R.; Nishonov, Bakhriddin; Fayzieva, Dilorom; Saito, L.; Lamers, J.

2009-01-01

The Khorezm province in northwest Uzbekistan is a productive agricultural area within the Aral Sea Basin that produces cotton, rice and wheat. Various organochlorine pesticides were widely used for cotton production before Uzbekistan's independence in 1991. In Khorezm, small lakes have formed in natural depressions that receive inputs mostly from agricultural runoff. Samples from lake waters and sediments, as well as water from the Amu Darya River (which is the source of most of the lake water) have been analyzed to study variations in the concentrations of organochlorine pesticides residues during the year. Low concentrations of DDT, DDD, DDE, a-HCH and y-HCH compounds were found in water and sediment samples. The concentration of persistent organochlorine pesticides (DDT and HCH) in water and sediment is much lower than the maximum permissible concentrations that exist for water and soil. According to these preliminary results, the investigated lakes in Khorezm appear to be suitable for recreation or for aquaculture.

Worldwide Emerging Environmental Issues Affecting the U.S. Military. September 2007 Report

DTIC Science & Technology

2007-09-01

5 5.1.2 Progress on the Nuclear- Test -Ban Treaty……………………………………………...6 5.1.3 Nuclear Disarmament………………………………………………………………..…6 5.1.4 IAEA...9 5.4.6 Post-Kyoto Negotiations……………………………………………………………….9 5.5 UNESCO Added 23 New Reserve Sites in 18 Countries……………………………………10 5.6... Semipalatinsk Nuclear Ground, the Amu-Darya river basin, and the Aral Sea. Military Implications: CENTCOM and military stationed in the East Caspian

On-chip quantum interference of a superconducting microsphere

NASA Astrophysics Data System (ADS)

Pino, H.; Prat-Camps, J.; Sinha, K.; Prasanna Venkatesh, B.; Romero-Isart, O.

2018-04-01

We propose and analyze an all-magnetic scheme to perform a Young’s double slit experiment with a micron-sized superconducting sphere of mass ≳ {10}13 amu. We show that its center of mass could be prepared in a spatial quantum superposition state with an extent of the order of half a micrometer. The scheme is based on magnetically levitating the sphere above a superconducting chip and letting it skate through a static magnetic potential landscape where it interacts for short intervals with quantum circuits. In this way, a protocol for fast quantum interferometry using quantum magnetomechanics is passively implemented. Such a table-top earth-based quantum experiment would operate in a parameter regime where gravitational energy scales become relevant. In particular, we show that the faint parameter-free gravitationally-induced decoherence collapse model, proposed by Diósi and Penrose, could be unambiguously falsified.

Interaction of Titan's ionosphere with Saturn's magnetosphere.

PubMed

Coates, Andrew J

2009-02-28

Titan is the only Moon in the Solar System with a significant permanent atmosphere. Within this nitrogen-methane atmosphere, an ionosphere forms. Titan has no significant magnetic dipole moment, and is usually located inside Saturn's magnetosphere. Atmospheric particles are ionized both by sunlight and by particles from Saturn's magnetosphere, mainly electrons, which reach the top of the atmosphere. So far, the Cassini spacecraft has made over 45 close flybys of Titan, allowing measurements in the ionosphere and the surrounding magnetosphere under different conditions. Here we review how Titan's ionosphere and Saturn's magnetosphere interact, using measurements from Cassini low-energy particle detectors. In particular, we discuss ionization processes and ionospheric photoelectrons, including their effect on ion escape from the ionosphere. We also discuss one of the unexpected discoveries in Titan's ionosphere, the existence of extremely heavy negative ions up to 10000amu at 950km altitude.

ISP Descriptions of Four Military Computer Architectures

DTIC Science & Technology

1978-04-01

9 1? LOAD "AGNITLII II Ill FO El 2 *> lorto0c VS * Lga ?i LOAD B AmU I 22 5LXt.At*Cf S Set 1 23 STORE 1 $A[ I 24 STORE A 5xg9 I 2S STORE a r-W I WE...HOOP: 79 3 0051E WLEVINt A Os’tx I 70 i opE!’ I 70 6 DPEI: 70 5 GPO !’ 70’ 7 HOP. I ?21 120 4 LOGCALSU He: 1 72 2 SLIM HANi I 72 2 OIMPENtCI I44OR2 I7...34. 15111 ’IflCfNI.CIJI no0 ,3 F4 ’l1’ 11. W hVI tWtJ-W J p O5-2 VS PAP I I 1 3.), \\F) PrI30("I I. \\c PAP141 dtitt-r(17󈧤>i \\D P0PISI -d.11wC27,32): \\U

Low-velocity ion stopping in a dense and low-temperature plasma target

NASA Astrophysics Data System (ADS)

Deutsch, Claude; Popoff, Romain

2007-07-01

We investigate the stopping specificities involved in the heating of thin foils irradiated by intense ion beams in the 0.3-3 MeV/amu energy range and in close vicinity of the Bragg peak. Considering a swiftly ionized target to eV temperatures before expansion while retaining solid-state density, a typical warm dense matter (WDM) situation thus arises. We stress low Vp stopping through ion diffusion in the given target plasma. This allows to include the case of a strongly magnetized target in a guiding center approximation. We also demonstrate that the ion projectile penetration depth in target is significantly affected by multiple scattering on target electrons. The given plasma target is taken weakly coupled with Maxwell electron either with no magnetic field ( B=0) or strongly magnetized ( B≠0). Dynamical coupling between ion projectiles energy losses and projectiles charge state will also be addressed.

Titan's Complex Chemistry: Insights from the Lab

NASA Astrophysics Data System (ADS)

Horst, Sarah

2018-06-01

The Cassini-Huygens mission revealed Titan to be a complex world with physical processes reminiscent of other terrestrial planets, but chemistry that is unlike anywhere else in the Solar System. Titan's complex atmospheric chemistry converts N2 and CH4 into numerous, abundant organic molecules ranging from relatively simple hydrocarbons to ions with mass to charge ratios up to 10,000 amu/q. The molecules eventually settle to the surface where they can participate in and be modified by geological processes such as aeolian and fluvial erosion or undergo subsequent chemistry in Titan's lakes and seas or impact craters and potential cryovolcanic flows. From the processes leading to massive ion formation in the atmosphere to the behavior of saltating organic sands on the surface, laboratory experiments are playing a pivotal role in understanding Titan and expanding our understanding of planetary processes into new, exciting phase space.

Irradiation of 4H-SiC UV detectors with heavy ions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinina, E. V., E-mail: evk@mail.ioffe.ru; Lebedev, A. A.; Bogdanova, E.

Ultraviolet (UV) photodetectors based on Schottky barriers to 4H-SiC are formed on lightly doped n-type epitaxial layers grown by the chemical vapor deposition method on commercial substrates. The diode structures are irradiated at 25°C by 167-MeV Xe ions with a mass of 131 amu at a fluence of 6 × 10{sup 9} cm{sup −2}. Comparative studies of the optical and electrical properties of as-grown and irradiated structures with Schottky barriers are carried out in the temperature range 23–180°C. The specific features of changes in the photosensitivity and electrical characteristics of the detector structures are accounted for by the capture ofmore » photogenerated carriers into traps formed due to fluctuations of the conduction-band bottom and valence-band top, with subsequent thermal dissociation.« less

Cavity Control and Cooling of Nanoparticles in High Vacuum

NASA Astrophysics Data System (ADS)

Millen, James

2016-05-01

Levitated systems are a fascinating addition to the world of optically-controlled mechanical resonators. It is predicted that nanoparticles can be cooled to their c.o.m. ground state via the interaction with an optical cavity. By freeing the oscillator from clamping forces dissipation and decoherence is greatly reduced, leading to the potential to produce long-lived, macroscopically spread, mechanical quantum states, allowing tests of collapse models and any mass limit of quantum physics. Reaching the low pressures required to cavity-cool to the ground state has proved challenging. Our approach is to cavity cool a beam of nanoparticles in high vacuum. We can cool the c.o.m. motion of nanospheres, and control the rotation of nanorods, with the potential to produce cold, aligned nanostructures. Looking forward, we will utilize novel microcavities to enhance optomechanical cooling, preparing particles in a coherent beam ideally suited to ultra-high mass interferometry at 107 a.m.u.

Cavity Cooling of Nanoparticles: Towards Matter-Wave experiments

NASA Astrophysics Data System (ADS)

Millen, James; Kuhn, Stefan; Arndt, Markus

2016-05-01

Levitated systems are a fascinating addition to the world of optically-controlled mechanical resonators. It is predicted that nanoparticles can be cooled to their c.o.m. ground state via the interaction with an optical cavity. By freeing the oscillator from clamping forces dissipation and decoherence is greatly reduced, leading to the potential to produce long-lived, macroscopically spread, mechanical quantum states, allowing tests of collapse models and any mass limit of quantum physics. Reaching the low pressures required to cavity-cool to the ground state has proved challenging. Our approach is to cavity cool a beam of nanoparticles in high vacuum. We can cool the c.o.m. motion of nanospheres a few hundred nanometers in size. Looking forward, we will utilize novel microcavities to enhance optomechanical cooling, preparing particles in a coherent beam ideally suited to ultra-high mass interferometry at 107 a.m.u.

Anions in Cometary Comae

NASA Technical Reports Server (NTRS)

Charnley, Steven B.

2011-01-01

The presence of negative ions (anions) in cometary comae is known from Giotto mass spectrometry of IP/Halley. The anions 0-, OH-, C-, CH- and CN- have been detected, as well as unidentified anions with masses 22-65 and 85-110 amu (Chaizy et al. 1991). Organic molecular anions are known to have a significant impact on the charge balance of interstellar clouds and circumstellar envelopes and have been shown to act as catalysts for the gas-phase synthesis of larger hydrocarbon molecules in the ISM, but their importance in cometary comae has not yet been explored. We present details of the first attempt to model the chemistry of anions in cometary comae. Based on the combined chemical and hydro dynamical model of Rodgers & Charnley (2002), we investigate the role of large carbon-chain anions in cometary coma chemistry. We calculate the effects of these anions on coma thermodynamics, charge balance and examine their impact on molecule formation.

The Giotto electron plasma experiment

NASA Technical Reports Server (NTRS)

Reme, H.; Cotin, F.; Cros, A.; Medale, J. L.; Sauvaud, J. A.

1987-01-01

The RPA-Copernic experiment aboard Giotto is described. The experiment is designed to measure the three-dimensional distributions of electrons between 10 eV and 30 keV (by the RPA-1 EESA spectrometer) and the composition and distribution, close to the comet, of thermal positive ions in the mass range 10-213 amu (by the RPA-2 PICCA electrostatic mass analyzer). Three microprocessors interface RPA-1 EESA with RPA-2 PICCA and with the spacecraft and perform extensive onboard data processing. The experiment was operated successfully aboard the spacecraft in September 1985 during the encounter of Giotto with the comet Halley. The results provided by the EESA-1 indicate that the solar wind interaction with the comet Halley forms a well-defined bow shock with features quite different from the features of the comet Giacobini-Zinner bow shock; the data also showed a presence of accelerated keV electrons at the cometary bow shock, upstream and in the transition region.

Limit on rotational energy available to excite Jovian aurora

NASA Technical Reports Server (NTRS)

Eviatar, A.; Siscoe, G. L.

1980-01-01

There is a fundamental relationship between the power that is extracted from Jupiter's rotation to drive magnetospheric processes and the rate at which mass is injected into the Io plasma torus. Half of this power is consumed by bulk motion of the plasma and the other half represents an upper limit on the energy from rotation available for dissipation and in particular to excite the Jovian aurora. Since the rotation of the planet is the only plausible source of energy, the power inferred from the observed auroral intensities requires a plasma injection rate of 2.6 x 10 to the 29th AMU/sec or greater. This in turn leads to a residence time of a torus particle of 48 days or less. These results raise doubts about the applicability of equilibrium thermodynamics to the determination of plasma parameters in the Io torus.

Lake Sarez, Tajikistan

NASA Technical Reports Server (NTRS)

2002-01-01

Lake Sarez (top), deep in the Pamir mountains of Tajikistan, was created 90 years ago when a strong earthquake triggered a massive landslide that, in turn, became a huge dam along the Murghob River, now called the Usoi Dam. The resulting lake is perched above surrounding drainages at an elevation greater than 3000m, and is part of the watershed that drains the towering Akademi Nauk Range (see the regional image, lower). The lake is 61 km long and as deep as 500 m, and holds an estimated 17 cubic km of water. The area experiences considerable seismic activity, and scientists fear that part of the right bank may slump into the lake, creating a huge wave that will top over and possibly breach the natural dam. Such a wave would create a catastrophic flood downstream along the Bartang, Panj and Amu Darya Rivers, perhaps reaching all the way to the Aral Sea. Currently, central Asian governments, as well as the World Bank and the UN are monitoring the dam closely, and have proposed gradually lowering the lake level as a preventive measure. More information about the lake is available at the following web sites: Lake Sarez Study group, UN Report, Reliefweb Digital photograph numbers ISS002-E-7771 and ISS002-E-7479 were taken in the spring of 2001 from Space Station Alpha and are provided by the Earth Sciences and Image Analysis Laboratory at Johnson Space Center. Additional images taken by astronauts and cosmonauts can be viewed at the NASA-JSC Gateway to Astronaut Photography of Earth.

Agroforestry-based management of salt-affected croplands in irrigated agricultural landscape in Uzbekistan

NASA Astrophysics Data System (ADS)

Khamzina, Asia; Kumar, Navneet; Heng, Lee

2017-04-01

In the lower Amu Darya River Basin, the decades of intensive irrigation led to elevated groundwater tables, resulting in ubiquitous soil salinization and adverse impact on crop production. Field-scale afforestation trials and farm-scale economic analyses in the Khorezm region have determined that afforestation can be an environmentally and financially attractive land-use option for degraded croplands because it combines a diversified agricultural production, carbon sequestration, an improved soil health and minimizes the use of irrigation water. We examined prospects for upscaling afforestation activity for regional land-use planning considering prevailing constraints in irrigated agriculture landscape. Assessment of salinity-induced cropland productivity decline using satellite imagery of multiple spatial and temporal resolution revealed that 18-38% of the marginally productive or abandoned cropland might be considered for conversion to agroforestry. Furthermore, a regional-scale water balance suggests that most of these marginal croplands are characterized by sufficient surface water supplies for irrigating the newly planted saplings, before they are able to rely on the groundwater alone. However, the 10-year monitoring of soil salt dynamics in the afforestation trials reveals increasing salinity levels due to the salt exclusion from the root water uptake by the trees. Further study focuses on enhancing long-term sustainability of afforestation as a management option for highly saline lands by examining salt tolerance of candidate species using 13C isotopic signature as the indicator of water and salt stress, salt leaching needs and implications for regional scale planning.

Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes

NASA Astrophysics Data System (ADS)

Worgul, B. V.; Smilenov, L.; Brenner, D. J.; Vazquez, M.; Hall, E. J.

Previous studies have shown that the eyes of ATM heterozygous mice exposed to low-LET radiation (X-rays) are significantly more susceptible to the development of cataracts than are those of wildtype mice. The findings, as well as others, run counter to the assumption underpinning current radiation safety guidelines, that individuals are all equally sensitive to the biological effects of radiation. A question, highly relevant to human space activities is whether or not, in similar fashion there may exist a genetic predisposition to high-LET radiation damage. Mice haplodeficient for the ATM gene and wildtypes were exposed to 325 mGy of 1 GeV/amu 56Fe ions at the AGS facility of Brookhaven National Laboratory. The fluence was equivalent to 1 ion per lens epithelial cell nuclear area. Controls consisted of irradiated wildtype as well as unirradiated wildtype and heterozygous mice. Prevalence analyses for stage 0.5-3.0 cataracts indicated that not only cataract onset but also progression were accelerated in the mice haplo-deficient for the ATM gene. The data show that heterozygosity for the ATM gene predisposes the eye to the cataractogenic influence of heavy ions and suggest that ATM heterozygotes in the human population may also be radiosensitive. This may have to be considered in the selection of individuals who will be exposed to both HZE particles and low-LET radiation as they may be predisposed to increased late normal tissue damage.

Using Cloud-to-Ground Lightning Climatologies to Initialize Gridded Lightning Threat Forecasts for East Central Florida

NASA Technical Reports Server (NTRS)

Lambert, Winnie; Sharp, David; Spratt, Scott; Volkmer, Matthew

2005-01-01

Each morning, the forecasters at the National Weather Service in Melbourn, FL (NWS MLB) produce an experimental cloud-to-ground (CG) lightning threat index map for their county warning area (CWA) that is posted to their web site (http://www.srh.weather.gov/mlb/ghwo/lightning.shtml) . Given the hazardous nature of lightning in central Florida, especially during the warm season months of May-September, these maps help users factor the threat of lightning, relative to their location, into their daily plans. The maps are color-coded in five levels from Very Low to Extreme, with threat level definitions based on the probability of lightning occurrence and the expected amount of CG activity. On a day in which thunderstorms are expected, there are typically two or more threat levels depicted spatially across the CWA. The locations of relative lightning threat maxima and minima often depend on the position and orientation of the low-level ridge axis, forecast propagation and interaction of sea/lake/outflow boundaries, expected evolution of moisture and stability fields, and other factors that can influence the spatial distribution of thunderstorms over the CWA. The lightning threat index maps are issued for the 24-hour period beginning at 1200 UTC (0700 AM EST) each day with a grid resolution of 5 km x 5 km. Product preparation is performed on the AWIPS Graphical Forecast Editor (GFE), which is the standard NWS platform for graphical editing. Currently, the forecasters create each map manually, starting with a blank map. To improve efficiency of the forecast process, NWS MLB requested that the Applied Meteorology Unit (AMU) create gridded warm season lightning climatologies that could be used as first-guess inputs to initialize lightning threat index maps. The gridded values requested included CG strike densities and frequency of occurrence stratified by synoptic-scale flow regime. The intent is to increase consistency between forecasters while enabling them to focus on the mesoscale detail of the forecast, ultimately benefiting the end-users of the product. Several studies took place at the Florida State University (FSU) and NWS Tallahassee (TAE) for which they created daily flow regimes using Florida 1200 UTC synoptic soundings and CG strike densities from National Lightning Detection Network (NLDN) data. The densities were created on a 2.5 km x 2.5 km grid for every hour of every day during the warm seasons in the years 1989-2004. The grids encompass an area that includes the entire state of Florida and adjacent Atlantic and Gulf of Mexico waters. Personnel at the two organizations provided this data and supporting software for the work performed by the AMU. The densities were first stratified by flow regime, then by time in 1-, 3-, 6-, 12-, and 24-hour increments while maintaining the 2.5 km x 2.5 km grid resolution. A CG frequency of occurrence was calculated for each stratification and grid box by counting the number of days with lightning and dividing by the total number of days in the data set. New CG strike densities were calculated for each stratification and grid box by summing the strike number values over all warm seasons, then normalized by dividing the summed values by the number of lightning days. This makes the densities conditional on whether lightning occurred. The frequency climatology values will be used by forecasters as proxy inputs for lightning prObability, while the density climatology values will be used for CG amount. In addition to the benefits outlined above, these climatologies will provide improved temporal and spatial resolution, expansion of the lightning threat area to include adjacent coastal waters, and potential to extend the forecast to include the day-2 period. This presentation will describe the lightning threat index map, discuss the work done to create the maps initialized with climatological guidance, and show examples of the climatological CG lightning densities and frequencies of occurren based on flow regime.

Chromatographic speciation of Cr(III)-species, inter-species equilibrium isotope fractionation and improved chemical purification strategies for high-precision isotope analysis.

PubMed

Larsen, K K; Wielandt, D; Schiller, M; Bizzarro, M

2016-04-22

Chromatographic purification of chromium (Cr), which is required for high-precision isotope analysis, is complicated by the presence of multiple Cr-species with different effective charges in the acid digested sample aliquots. The differing ion exchange selectivity and sluggish reaction rates of these species can result in incomplete Cr recovery during chromatographic purification. Because of large mass-dependent inter-species isotope fractionation, incomplete recovery can affect the accuracy of high-precision Cr isotope analysis. Here, we demonstrate widely differing cation distribution coefficients of Cr(III)-species (Cr(3+), CrCl(2+) and CrCl2(+)) with equilibrium mass-dependent isotope fractionation spanning a range of ∼1‰/amu and consistent with theory. The heaviest isotopes partition into Cr(3+), intermediates in CrCl(2+) and the lightest in CrCl2(+)/CrCl3°. Thus, for a typical reported loss of ∼25% Cr (in the form of Cr(3+)) through chromatographic purification, this translates into 185 ppm/amu offset in the stable Cr isotope ratio of the residual sample. Depending on the validity of the mass-bias correction during isotope analysis, this further results in artificial mass-independent effects in the mass-bias corrected (53)Cr/(52)Cr (μ(53)Cr* of 5.2 ppm) and (54)Cr/(52)Cr (μ(54)Cr* of 13.5 ppm) components used to infer chronometric and nucleosynthetic information in meteorites. To mitigate these fractionation effects, we developed strategic chemical sample pre-treatment procedures that ensure high and reproducible Cr recovery. This is achieved either through 1) effective promotion of Cr(3+) by >5 days exposure to HNO3H2O2 solutions at room temperature, resulting in >∼98% Cr recovery for most types of sample matrices tested using a cationic chromatographic retention strategy, or 2) formation of Cr(III)-Cl complexes through exposure to concentrated HCl at high temperature (>120 °C) for several hours, resulting in >97.5% Cr recovery using a chromatographic elution strategy that takes advantage of the slow reaction kinetics of de-chlorination of Cr in dilute HCl at room temperature. These procedures significantly improve cation chromatographic purification of Cr over previous methods and allow for high-purity Cr isotope analysis with a total recovery of >95%. Copyright © 2016 Elsevier B.V. All rights reserved.

Chromatographic speciation of Cr(III)-species, inter-species equilibrium isotope fractionation and improved chemical purification strategies for high-precision isotope analysis

PubMed Central

Larsen, K.K.; Wielandt, D.; Schiller, M.; Bizzarro, M.

2016-01-01

Chromatographic purification of chromium (Cr), which is required for high-precision isotope analysis, is complicated by the presence of multiple Cr-species with different effective charges in the acid digested sample aliquots. The differing ion exchange selectivity and sluggish reaction rates of these species can result in incomplete Cr recovery during chromatographic purification. Because of large mass-dependent inter-species isotope fractionation, incomplete recovery can affect the accuracy of high-precision Cr isotope analysis. Here, we demonstrate widely differing cation distribution coefficients of Cr(III)-species (Cr3+, CrCl2+ and CrCl2+) with equilibrium mass-dependent isotope fractionation spanning a range of ~1‰/amu and consistent with theory. The heaviest isotopes partition into Cr3+, intermediates in CrCl2+ and the lightest in CrCl2+/CrCl3°. Thus, for a typical reported loss of ~25% Cr (in the form of Cr3+) through chromatographic purification, this translates into 185 ppm/amu offset in the stable Cr isotope ratio of the residual sample. Depending on the validity of the mass-bias correction during isotope analysis, this further results in artificial mass-independent effects in the mass-bias corrected 53Cr/52Cr (μ53 Cr* of 5.2 ppm) and 54Cr/52Cr (μ54Cr* of 13.5 ppm) components used to infer chronometric and nucleosynthetic information in meteorites. To mitigate these fractionation effects, we developed strategic chemical sample pre-treatment procedures that ensure high and reproducible Cr recovery. This is achieved either through 1) effective promotion of Cr3+ by >5 days exposure to HNO3 —H2O2 solutions at room temperature, resulting in >~98% Cr recovery for most types of sample matrices tested using a cationic chromatographic retention strategy, or 2) formation of Cr(III)-Cl complexes through exposure to concentrated HCl at high temperature (>120 °C) for several hours, resulting in >97.5% Cr recovery using a chromatographic elution strategy that takes advantage of the slow reaction kinetics of de-chlorination of Cr in dilute HCl at room temperature. These procedures significantly improve cation chromatographic purification of Cr over previous methods and allow for high-purity Cr isotope analysis with a total recovery of >95%. PMID:27036208

Monte-Carlo Simulation of Radiation Track Structure and Calculation of Dose Deposition in Nanovolumes

NASA Technical Reports Server (NTRS)

Plante, I.; Cucinotta, F. A.

2010-01-01

INTRODUCTION: The radiation track structure is of crucial importance to understand radiation damage to molecules and subsequent biological effects. Of a particular importance in radiobiology is the induction of double-strand breaks (DSBs) by ionizing radiation, which are caused by clusters of lesions in DNA, and oxidative damage to cellular constituents leading to aberrant signaling cascades. DSB can be visualized within cell nuclei with gamma-H2AX experiments. MATERIAL AND METHODS: In DSB induction models, the DSB probability is usually calculated by the local dose obtained from a radial dose profile of HZE tracks. In this work, the local dose imparted by HZE ions is calculated directly from the 3D Monte-Carlo simulation code RITRACKS. A cubic volume of 5 micron edge (Figure 1) is irradiated by a (Fe26+)-56 ion of 1 GeV/amu (LET approx.150 keV/micron) and by a fluence of 450 H+ ions, 300 MeV/amu (LET approx. 0.3 keV/micron). In both cases, the dose deposited in the volume is approx.1 Gy. The dose is then calculated into each 3D pixels (voxels) of 20 nm edge and visualized in 3D. RESULTS AND DISCUSSION: The dose is deposited uniformly in the volume by the H+ ions. The voxels which receive a high dose (orange) corresponds to electron track ends. The dose is deposited differently by the 56Fe26+ ion. Very high dose (red) is deposited in voxels with direct ion traversal. Voxels with electron track ends (orange) are also found distributed around the path of the track. In both cases, the appearance of the dose distribution looks very similar to DSBs seen in gammaH2AX experiments, particularly when the visualization threshold is applied. CONCLUSION: The refinement of the dose calculation to the nanometer scale has revealed important differences in the energy deposition between high- and low-LET ions. Voxels of very high dose are only found in the path of high-LET ions. Interestingly, experiments have shown that DSB induced by high-LET radiation are more difficult to repair. Therefore, this new approach may be useful to understand the nature of DSB and oxidative damage induced by ionizing radiation.

Discharge patterns of human genioglossus motor units during arousal from sleep.

PubMed

Wilkinson, Vanessa; Malhotra, Atul; Nicholas, Christian L; Worsnop, Christopher; Jordan, Amy S; Butler, Jane E; Saboisky, Julian P; Gandevia, Simon C; White, David P; Trinder, John

2010-03-01

Single motor unit recordings of the human genioglossus muscle reveal motor units with a variety of discharge patterns. Integrated multiunit electromyographic recordings of genioglossus have demonstrated an abrupt increase in the muscle's activity at arousal from sleep. The aim of the present study was to determine the effect of arousal from sleep on the activity of individual motor units as a function of their particular discharge pattern. Genioglossus activity was measured using intramuscular fine-wire electrodes inserted via a percutaneous approach. Arousals from sleep were identified using the ASDA criterion and the genioglossus electromyogram recordings analyzed for single motor unit activity. Sleep research laboratory. Sleep and respiratory data were collected in 8 healthy subjects (6 men). 138 motor units were identified during prearousalarousal sleep: 25% inspiratory phasic, 33% inspiratory tonic, 4% expiratory phasic, 3% expiratory tonic, and 35% tonic. At arousal from sleep inspiratory phasic units significantly increased the proportion of a breath over which they were active, but did not appreciably increase their rate of firing. 80 new units were identified at arousals, 75% were inspiratory, many of which were active for only 1 or 2 breaths. 22% of units active before arousal, particularly expiratory and tonic units, stopped at the arousal. Increased genioglossus muscle activity at arousal from sleep is primarily due to recruitment of inspiratory phasic motor units. Further, activity within the genioglossus motoneuron pool is reorganized at arousal as, in addition to recruitment, approximately 20% of units active before arousals stopped firing.

Properties of the Medussae Fossae Formation and its relation to the volcanic history of Mars

NASA Astrophysics Data System (ADS)

Ivanov, Anton B.; Cantini, Federico

2016-10-01

Medussae Fossae (MFF) is a well known formation, stretching west of Tharsis volanoes. It is characterized as a relatively young Amazonian units (Amm, Amu), due to widespread signs of erosion. Earth based imaging radar observations at 3.5 cm [1] and 12 cm [2] have discovered a dark radar feature (Stealth), which roughly correlates with the MFF outline.Recent investigations [3], suggested that the unit emplacement is in fact during Hesperian period, but it is composed of material that can be easily eroded. It is not clear when the erosion happened and if it is a continuing process. Hypotheses on MFF formation range from volcanic material emplacement (ash flow tuffs or pyroclastic materials) to an ice-rich dusty mantle, deposited during high obliquity.In this work, we will present the latest observations of the East Medussae Fossae formation by the long wavelength MARSIS radar, continuing the work reported in [4], as well as complementing data surveyed by SHARAD data in [5]. The MARSIS radar has detected strong subsurface interfaces in the areas of Gordi and Eumenides Dorsae at depths up to 1.5km. We will present our analysis of the data, inferring the dielectric properties of the material to constrain properties of the material constituting the Medusae Fossae formation. We will also demonstrate an efficient user interface to work with MARSIS data inside a Geographical Information System (GIS).The research leading to these results has received funding from the European Unions Seventh Framework Programme (FP7/2007-2013) under iMars grant agreement 607379.[1] D. Muhleman, et al., "Radar images of mars," Science, vol. 253, no. 5027, 1991.[2] J. K. Harmon, et al., "Arecibo radar imagery of Mars: The major volcanic provinces," Icarus, vol. 220, aug 2012.[3] L. Kerber, et al., "The dispersal of pyroclasts from Apollinaris Patera, Mars: Implications for the origin of the Medusae Fossae Formation," Icarus, vol. 216, nov 2011.[4] T. R. Watters, et al., "Radar Sounding of the Medusae Fossae Formation Mars: Equatorial Ice or Dry, Low-Density Deposits?," Science, vol. 318, nov 2007.[5] L. M. Carter, et al., "Shallow radar (SHARAD) sounding observations of the Medusae Fossae Formation, Mars," Icarus, vol. 199, pp. , feb 2009.

[Career Awareness Units. Grades K-6.

ERIC Educational Resources Information Center

Price, Peggy R.; And Others

The 13 units outline activities focusing on particular occupations and skills integrated with language arts, mathematics, science, social studies, and other areas. Unit One, for the kindergarten level, contains 11 activities centering on helpers for the home. Unit Two examines restaurant occupations through 10 activities. The six activities in…

The effect of fast and slow motor unit activation on whole-muscle mechanical performance: the size principle may not pose a mechanical paradox

PubMed Central

Holt, N. C.; Wakeling, J. M.; Biewener, A. A.

2014-01-01

The output of skeletal muscle can be varied by selectively recruiting different motor units. However, our knowledge of muscle function is largely derived from muscle in which all motor units are activated. This discrepancy may limit our understanding of in vivo muscle function. Hence, this study aimed to characterize the mechanical properties of muscle with different motor unit activation. We determined the isometric properties and isotonic force–velocity relationship of rat plantaris muscles in situ with all of the muscle active, 30% of the muscle containing predominately slower motor units active or 20% of the muscle containing predominately faster motor units active. There was a significant effect of active motor unit type on isometric force rise time (p < 0.001) and the force–velocity relationship (p < 0.001). Surprisingly, force rise time was longer and maximum shortening velocity higher when all motor units were active than when either fast or slow motor units were selectively activated. We propose this is due to the greater relative effects of factors such as series compliance and muscle resistance to shortening during sub-maximal contractions. The findings presented here suggest that recruitment according to the size principle, where slow motor units are activated first and faster ones recruited as demand increases, may not pose a mechanical paradox, as has been previously suggested. PMID:24695429

The effect of fast and slow motor unit activation on whole-muscle mechanical performance: the size principle may not pose a mechanical paradox.

PubMed

Holt, N C; Wakeling, J M; Biewener, A A

2014-05-22

The output of skeletal muscle can be varied by selectively recruiting different motor units. However, our knowledge of muscle function is largely derived from muscle in which all motor units are activated. This discrepancy may limit our understanding of in vivo muscle function. Hence, this study aimed to characterize the mechanical properties of muscle with different motor unit activation. We determined the isometric properties and isotonic force-velocity relationship of rat plantaris muscles in situ with all of the muscle active, 30% of the muscle containing predominately slower motor units active or 20% of the muscle containing predominately faster motor units active. There was a significant effect of active motor unit type on isometric force rise time (p < 0.001) and the force-velocity relationship (p < 0.001). Surprisingly, force rise time was longer and maximum shortening velocity higher when all motor units were active than when either fast or slow motor units were selectively activated. We propose this is due to the greater relative effects of factors such as series compliance and muscle resistance to shortening during sub-maximal contractions. The findings presented here suggest that recruitment according to the size principle, where slow motor units are activated first and faster ones recruited as demand increases, may not pose a mechanical paradox, as has been previously suggested.

Adjustments differ among low-threshold motor units during intermittent, isometric contractions.

PubMed

Farina, Dario; Holobar, Ales; Gazzoni, Marco; Zazula, Damjan; Merletti, Roberto; Enoka, Roger M

2009-01-01

We investigated the changes in muscle fiber conduction velocity, recruitment and derecruitment thresholds, and discharge rate of low-threshold motor units during a series of ramp contractions. The aim was to compare the adjustments in motor unit activity relative to the duration that each motor unit was active during the task. Multichannel surface electromyographic (EMG) signals were recorded from the abductor pollicis brevis muscle of eight healthy men during 12-s contractions (n = 25) in which the force increased and decreased linearly from 0 to 10% of the maximum. The maximal force exhibited a modest decline (8.5 +/- 9.3%; P < 0.05) at the end of the task. The discharge times of 73 motor units that were active for 16-98% of the time during the first five contractions were identified throughout the task by decomposition of the EMG signals. Action potential conduction velocity decreased during the task by a greater amount for motor units that were initially active for >70% of the time compared with that of less active motor units. Moreover, recruitment and derecruitment thresholds increased for these most active motor units, whereas the thresholds decreased for the less active motor units. Another 18 motor units were recruited at an average of 171 +/- 32 s after the beginning of the task. The recruitment and derecruitment thresholds of these units decreased during the task, but muscle fiber conduction velocity did not change. These results indicate that low-threshold motor units exhibit individual adjustments in muscle fiber conduction velocity and motor neuron activation that depended on the relative duration of activity during intermittent contractions.

36 CFR 9.83 - Coordination of AMRAP activities in National Park System units.

Code of Federal Regulations, 2014 CFR

2014-07-01

... activities in National Park System units. 9.83 Section 9.83 Parks, Forests, and Public Property NATIONAL PARK... Coordination of AMRAP activities in National Park System units. (a) To facilitate compliance with this Subpart... agreeable schedule of AMRAP projects and activities in Alaska units of the National Park System. Where...

36 CFR 9.83 - Coordination of AMRAP activities in National Park System units.

Code of Federal Regulations, 2012 CFR

2012-07-01

... activities in National Park System units. 9.83 Section 9.83 Parks, Forests, and Public Property NATIONAL PARK... Coordination of AMRAP activities in National Park System units. (a) To facilitate compliance with this Subpart... agreeable schedule of AMRAP projects and activities in Alaska units of the National Park System. Where...

36 CFR 9.83 - Coordination of AMRAP activities in National Park System units.

Code of Federal Regulations, 2011 CFR

2011-07-01

... activities in National Park System units. 9.83 Section 9.83 Parks, Forests, and Public Property NATIONAL PARK... Coordination of AMRAP activities in National Park System units. (a) To facilitate compliance with this Subpart... agreeable schedule of AMRAP projects and activities in Alaska units of the National Park System. Where...

36 CFR 9.83 - Coordination of AMRAP activities in National Park System units.

Code of Federal Regulations, 2010 CFR

2010-07-01

... activities in National Park System units. 9.83 Section 9.83 Parks, Forests, and Public Property NATIONAL PARK... Coordination of AMRAP activities in National Park System units. (a) To facilitate compliance with this Subpart... agreeable schedule of AMRAP projects and activities in Alaska units of the National Park System. Where...