Agricultural production and nutrient runoff in the Corn Belt ...

EPA Pesticide Factsheets

Agricultural production in the Corn Belt region of the Upper Mississippi River Basin (UMRB) remains a leading source of nitrogen runoff that contributes to the annual hypoxic 'Dead Zone' in the Gulf of Mexico. The rise of corn production, land conversion, and fertilizer use in response to ethanol policy incentives in recent years is well documented and may worsen this effect. We develop a spatially distributed dynamic environmental performance index (EPI), accounting for both desirable agricultural outputs and undesirable nonpoint source emissions from farm production, to examine the corresponding changes in environmental performance within the UMRB between 2002 and 2007, which is characterized by increasing policy incentives for ethanol production. County-level production data from the USDA agricultural census are aggregated to hydrologic unit code (HUC8) boundaries using a geographic information system (GIS), and a previously developed statistical model, which includes net anthropogenic nitrogen inputs (NANI) as well as precipitation and land use characteristics as inputs, is used to estimate annual nitrogen loadings delivered to streams from HUC8 watersheds. The EPI allows us to decompose performance of each HUC8 region over time into changes in productive efficiency and emissions efficiency. To our knowledge, this is the first study to examine the corresponding changes in environmental performance for producers in this region at the watershed scale. The resu

Levee Presence and Wetland Areas within the 100-Year Floodplain of the Wabash Basin

NASA Astrophysics Data System (ADS)

Morrison, R. R.; Dong, Q.; Nardi, F.; Grantham, T.; Annis, A.

2016-12-01

Wetlands have declined over the past century due to land use changes and water management activities in the United States. Levees have been extensively built to provide protection against flooding events, and can fundamentally alter the water distribution and hydrologic dynamics within floodplains. Although levees can reduce wetlands in many places, it is unclear how much wetland areas are impacted at a basin-scale. This study explores the relationship between wetlands, levee presence, and other important hydrologic metrics within a 100-year floodplain. We estimated total wetland area, levee length, floodplain area and other variables, in discrete 12-digit hydrologic units (HUC-12) of the Wabash Basin (n=854) and examined the relationship between these variables using non-parametric statistical tests. We found greater areas of wetland habitat in HUC12 units that contain levees compared to those without levees when we aggregated the results across the entire basin. Factors such as stream order, mean annual flow, and HUC12 area are not correlated with the wetland area in HUC-12 units that contain levees. In addition, median wetland area in HUC12 units with levees is surprisingly consistent regardless of maximum stream order. Visual observations of wetland distributions indicate that wetland presence may be dependent on its location relative to levees. These results indicate that refined geospatial analyses may be necessary to explore the complex influence of levees on wetland habitat, and that additional basins should be explored to develop more generalized trends. This information is preliminary and subject to revision.

NYC Reservoirs Watershed Areas (HUC 12)

EPA Pesticide Factsheets

This NYC Reservoirs Watershed Areas (HUC 12) GIS layer was derived from the 12-Digit National Watershed Boundary Database (WBD) at 1:24,000 for EPA Region 2 and Surrounding States. HUC 12 polygons were selected from the source based on interactively comparing these HUC 12s in our GIS with images of the New York City's Water Supply System Map found at http://www.nyc.gov/html/dep/html/drinking_water/wsmaps_wide.shtml. The 12 digit Hydrologic Units (HUCs) for EPA Region 2 and surrounding states (Northeastern states, parts of the Great Lakes, Puerto Rico and the USVI) are a subset of the National Watershed Boundary Database (WBD), downloaded from the Natural Resources Conservation Service (NRCS) Geospatial Gateway and imported into the EPA Region 2 Oracle/SDE database. This layer reflects 2009 updates to the WBD that included new boundary data for New York and New Jersey.

Assessment of the Temporal Evolution of Storm Surge via Land to Water Isopleths in Coastal Louisiana

NASA Astrophysics Data System (ADS)

Siverd, C. G.; Hagen, S. C.; Bilskie, M. V.; Braud, D.; Gao, S.; Peele, H.; Twilley, R.

2017-12-01

The low-lying coastal Louisiana deltaic landscape features an intricate system of fragmented wetlands, natural ridges, man-made navigation canals and flood protection infrastructure. Since 1900 and prior to the landfall of Hurricane Katrina in 2005, Louisiana lost approximately 480,000 ha (1,850 sq mi) of coastal wetlands and an additional 20,000 ha (77 sq mi) due to Katrina. This resulted in a total wetland storm protection value loss of USD 28.3 billion and USD 1.1 billion, respectively (Costanza 2008). To investigate the response of hurricane storm surge (e.g. peak water levels, inundation time and extent) through time due to land loss, hydrodynamic models that represent historical eras of the Louisiana coastal landscape were developed. Land:Water (L:W) isopleths (Gagliano 1970, 1971, Twilley 2016) have been calculated along the coast from the Sabine River to the Pearl River. These isopleths were utilized to create a simplified coastal landscape (bathymetry, topography, bottom roughness) representing circa 2010. Similar methodologies are employed with the objective of developing storm surge models that represent the coastal landscape for past eras. The goal is to temporally examine the evolution of storm surge along coastal Louisiana. The isopleths determined to best represent the Louisiana coast as a result of the methodology devised to develop the simple storm surge model for c.2010 are applied in the development of surge models for historical eras c.1930 and c.1970. The ADvaced CIRCulation (ADCIRC) code (Luettich 2004) is used to perform storm surge simulations with a predetermined suite of hurricane wind and pressure forcings. Hydrologic Unit Code 12 (HUC12) sub-watersheds provide geographical bounds to quantify mean maximum water surface elevations (WSEs), volume of inundation, and area of inundation. HUC12 sub-watersheds also provide a means to compare/contrast these quantified surge parameters on a HUC12-by-HUC12 basis for the c.1930, c.1970 and c.2010 eras. Results will provide insight into how storm surge has evolved in coastal Louisiana from 1930 to 2010 and assist to inform policy makers of regions with temporally accelerating storm surge.

EnviroAtlas - Agricultural Water Demand by 12-Digit HUC for the Conterminous United States

EPA Pesticide Factsheets

The national agricultural water demand metric provides insight into the amount of water currently used for agricultural irrigation in the contiguous United States. The values are based on 2005 irrigation water use; combined 2010 crop, 2006 land use, and 2001 remotely sensed irrigation location estimates; and have been summarized by watershed or 12-digit hydrologic unit code (HUC). Agricultural irrigation water use, as defined in this case, meets a variety of needs before, during, and after growing seasons (e.g., dust suppression, field preparation, chemical application, weed control, salt removal from root zones, frost protection, crop cooling, and harvesting). Estimates include self-supplied surface and groundwater, as well as supplies from irrigation-specific organizations (e.g., companies, districts, cooperatives, government). This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas - Domestic Water Demand by 12-Digit HUC for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset includes domestic water demand attributes which provide insight into the amount of water currently used for indoor and outdoor residential purposes in the contiguous United States. The values are based on 2010 water demand and 2010 population distribution, and have been summarized by subwatershed, or 12-digit hydrologic unit code (HUC12). For the purposes of this metric, domestic water use includes residential uses, such as for drinking, bathing, cleaning, landscaping, and pools. Depending on the location, domestic water can be self-supplied, such as by private wells, or publicly-supplied, such as by municipalities. Sources include surface water and groundwater. Estimates are for primary residences only (i.e., excluding second homes and tourism rentals). This dataset was produced by the US EPA to support research and online mapping activities related to the EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Spatial variability in nutrient transport by HUC8, state, and subbasin based on Mississippi/Atchafalaya River Basin SPARROW models

USGS Publications Warehouse

Robertson, Dale M.; Saad, David A.; Schwarz, Gregory E.

2014-01-01

Nitrogen (N) and phosphorus (P) loading from the Mississippi/Atchafalaya River Basin (MARB) has been linked to hypoxia in the Gulf of Mexico. With geospatial datasets for 2002, including inputs from wastewater treatment plants (WWTPs), and monitored loads throughout the MARB, SPAtially Referenced Regression On Watershed attributes (SPARROW) watershed models were constructed specifically for the MARB, which reduced simulation errors from previous models. Based on these models, N loads/yields were highest from the central part (centered over Iowa and Indiana) of the MARB (Corn Belt), and the highest P yields were scattered throughout the MARB. Spatial differences in yields from previous studies resulted from different descriptions of the dominant sources (N yields are highest with crop-oriented agriculture and P yields are highest with crop and animal agriculture and major WWTPs) and different descriptions of downstream transport. Delivered loads/yields from the MARB SPARROW models are used to rank subbasins, states, and eight-digit Hydrologic Unit Code basins (HUC8s) by N and P contributions and then rankings are compared with those from other studies. Changes in delivered yields result in an average absolute change of 1.3 (N) and 1.9 (P) places in state ranking and 41 (N) and 69 (P) places in HUC8 ranking from those made with previous national-scale SPARROW models. This information may help managers decide where efforts could have the largest effects (highest ranked areas) and thus reduce hypoxia in the Gulf of Mexico.

A comprehensive evaluation of two MODIS evapotranspiration products over the conterminous United States: using point and gridded FLUXNET and water balance ET

USGS Publications Warehouse

Velpuri, Naga M.; Senay, Gabriel B.; Singh, Ramesh K.; Bohms, Stefanie; Verdin, James P.

2013-01-01

Remote sensing datasets are increasingly being used to provide spatially explicit large scale evapotranspiration (ET) estimates. Extensive evaluation of such large scale estimates is necessary before they can be used in various applications. In this study, two monthly MODIS 1 km ET products, MODIS global ET (MOD16) and Operational Simplified Surface Energy Balance (SSEBop) ET, are validated over the conterminous United States at both point and basin scales. Point scale validation was performed using eddy covariance FLUXNET ET (FLET) data (2001–2007) aggregated by year, land cover, elevation and climate zone. Basin scale validation was performed using annual gridded FLUXNET ET (GFET) and annual basin water balance ET (WBET) data aggregated by various hydrologic unit code (HUC) levels. Point scale validation using monthly data aggregated by years revealed that the MOD16 ET and SSEBop ET products showed overall comparable annual accuracies. For most land cover types, both ET products showed comparable results. However, SSEBop showed higher performance for Grassland and Forest classes; MOD16 showed improved performance in the Woody Savanna class. Accuracy of both the ET products was also found to be comparable over different climate zones. However, SSEBop data showed higher skill score across the climate zones covering the western United States. Validation results at different HUC levels over 2000–2011 using GFET as a reference indicate higher accuracies for MOD16 ET data. MOD16, SSEBop and GFET data were validated against WBET (2000–2009), and results indicate that both MOD16 and SSEBop ET matched the accuracies of the global GFET dataset at different HUC levels. Our results indicate that both MODIS ET products effectively reproduced basin scale ET response (up to 25% uncertainty) compared to CONUS-wide point-based ET response (up to 50–60% uncertainty) illustrating the reliability of MODIS ET products for basin-scale ET estimation. Results from this research would guide the additional parameter refinement required for the MOD16 and SSEBop algorithms in order to further improve their accuracy and performance for agro-hydrologic applications.

GIS-based identification of areas with mineral resource potential for six selected deposit groups, Bureau of Land Management Central Yukon Planning Area, Alaska

USGS Publications Warehouse

Jones, James V.; Karl, Susan M.; Labay, Keith A.; Shew, Nora B.; Granitto, Matthew; Hayes, Timothy S.; Mauk, Jeffrey L.; Schmidt, Jeanine M.; Todd, Erin; Wang, Bronwen; Werdon, Melanie B.; Yager, Douglas B.

2015-01-01

This study has used a data-driven, geographic information system (GIS)-based method for evaluating the mineral resource potential across the large region of the CYPA. This method systematically and simultaneously analyzes geoscience data from multiple geospatially referenced datasets and uses individual subwatersheds (12-digit hydrologic unit codes or HUCs) as the spatial unit of classification. The final map output indicates an estimated potential (high, medium, low) for a given mineral deposit group and indicates the certainty (high, medium, low) of that estimate for any given subwatershed (HUC). Accompanying tables describe the data layers used in each analysis, the values assigned for specific analysis parameters, and the relative weighting of each data layer that contributes to the estimated potential and certainty determinations. Core datasets used include the U.S. Geological Survey (USGS) Alaska Geochemical Database (AGDB2), the Alaska Division of Geologic and Geophysical Surveys Web-based geochemical database, data from an anticipated USGS geologic map of Alaska, and the USGS Alaska Resource Data File. Map plates accompanying this report illustrate the mineral prospectivity for the six deposit groups across the CYPA and estimates of mineral resource potential. There are numerous areas, some of them large, rated with high potential for one or more of the selected deposit groups within the CYPA.

EnviroAtlas - Average Annual Precipitation 1981-2010 by HUC12 for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset provides the average annual precipitation by 12-digit Hydrologic Unit (HUC). The values were estimated from maps produced by the PRISM Climate Group, Oregon State University. The original data was at the scale of 800 m grid cells representing average precipitation from 1981-2010 in mm. The data was converted to inches of precipitation and then zonal statistics were estimated for a final value of average annual precipitation for each 12 digit HUC. For more information about the original dataset please refer to the PRISM website at http://www.prism.oregonstate.edu/. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Sensitivity of Regulated Flow Regimes to Climate Change in the Western United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Tian; Voisin, Nathalie; Leng, Guoyong

Water management activities or flow regulations modify water fluxes at the land surface and affect water resources in space and time. We hypothesize that flow regulations change the sensitivity of river flow to climate change with respect to unmanaged water resources. Quantifying these changes in sensitivity could help elucidate the impacts of water management at different spatiotemporal scales and inform climate adaptation decisions. In this study, we compared the emergence of significant changes in natural and regulated river flow regimes across the Western United States from simulations driven by multiple climate models and scenarios. We find that significant climate change-inducedmore » alterations in natural flow do not cascade linearly through water management activities. At the annual time scale, 50% of the Hydrologic Unit Code 4 (HUC4) sub-basins over the Western U.S. regions tend to have regulated flow regime more sensitive to the climate change than natural flow regime. Seasonality analyses show that the sensitivity varies remarkably across the seasons. We also find that the sensitivity is related to the level of water management. For 35% of the HUC4 sub-basins with the highest level of water management, the summer and winter flows tend to show a heightened sensitivity to climate change due to the complexity of joint reservoir operations. We further demonstrate that the impacts of considering water management in models are comparable to those that arises from uncertainties across climate models and emission scenarios. This prompts further climate adaptation studies research about nonlinearity effects of climate change through water management activities.« less

12-Digit Watershed Boundary Data 1:24,000 for EPA Region 2 and Surrounding States (NAT_HYDROLOGY.HUC12_NRCS_REG2)

EPA Pesticide Factsheets

12 digit Hydrologic Units (HUCs) for EPA Region 2 and surrounding states (Northeastern states, parts of the Great Lakes, Puerto Rico and the USVI) downloaded from the Natural Resources Conservation Service (NRCS) Geospatial Gateway and imported into the EPA Region 2 Oracle/SDE database. This layer reflects 2009 updates to the national Watershed Boundary Database (WBD) that included new boundary data for New York and New Jersey.

Infusion of Trx-1-Overexpressing hucMSC Prolongs the Survival of Acutely Irradiated NOD/SCID Mice by Decreasing Excessive Inflammatory Injury

PubMed Central

Wang, Jun; Tang, YongYong; Liu, Hao; Zhang, Bin; Chen, Hu

2013-01-01

A protective reagent for ARI should have the ability to repair injured tissue caused by radiation and prevent continuous damage from secondary risk factors. Trx-1 was explored as a candidate therapy for ARI, as it scavenges reactive oxygen species, regulates cell growth and differentiation, participates in immune reactions, and inhibits apoptosis by acting inside and/or outside cells. Trx-1 can also decrease excessive inflammation in ARI by regulating the creation of inflamed media, by inhibiting the activation of complement, and by reducing the chemotaxis, adhesion, and migration of inflammatory cells. As effectively and stably expressing exogenous genes in the long term and regulating immune inflammation and tissue repair, MSC are a good choice for Trx-1 gene therapy. In this study, Trx-1-overexpressing hucMSC-Trx-1 were obtained by adenoviral vector-mediated infection. We first measured the redox capacity of hucMSC-Trx-1 with an antioxidant capacity (T-AOC) assay, a hydrogen peroxide (H2O2) content determination assay in vivo, a H2O2-induced oxidation hemolysis assay, and a lipid peroxidation assay in vitro. Then, we measured survival time, the protection of the hematopoietic system, and the regulation of inflammation in important organs in three treatment groups of NOD/SCID mice (treated with hucMSC-Trx-1, with hucMSC, and with saline) that were exposed to 4.5 Gy 60Co-γ-ray radiation. The hucMSC-Trx-1 group achieved superior antioxidation results, protecting bone marrow hematopoietic stem cells (Lin−CD117+: hucMSC-Trx-1 vs. hucMSC, P<0.05; hucMSC-Trx-1 vs. NS, P<0.01), promoting the formation of red blood cells and hemoglobin (hucMSC-Trx-1 vs. hucMSC or NS, P<0.05), reducing inflammation and damage in important organs (Bone marrow and lung: hucMSC-Trx-1 vs. NS, P<0.01; hucMSC-Trx-1 vs. hucMSC, P<0.05. Liver and intestine: hucMSC-Trx-1 vs. NS, P<0.05; hucMSC-Trx-1 vs. hucMSC, P<0.05), and prolonging survival (hucMSC-Trx-1 vs. hucMSC or NS, P<0.01). Therefore, hucMSC-Trx-1 combines the merits of gene and cell therapy as a multifunctional radioprotector for ARI. PMID:24223778

Infusion of Trx-1-overexpressing hucMSC prolongs the survival of acutely irradiated NOD/SCID mice by decreasing excessive inflammatory injury.

PubMed

Hu, JiangWei; Yang, ZaiLiang; Wang, Jun; Tang, YongYong; Liu, Hao; Zhang, Bin; Chen, Hu

2013-01-01

A protective reagent for ARI should have the ability to repair injured tissue caused by radiation and prevent continuous damage from secondary risk factors. Trx-1 was explored as a candidate therapy for ARI, as it scavenges reactive oxygen species, regulates cell growth and differentiation, participates in immune reactions, and inhibits apoptosis by acting inside and/or outside cells. Trx-1 can also decrease excessive inflammation in ARI by regulating the creation of inflamed media, by inhibiting the activation of complement, and by reducing the chemotaxis, adhesion, and migration of inflammatory cells. As effectively and stably expressing exogenous genes in the long term and regulating immune inflammation and tissue repair, MSC are a good choice for Trx-1 gene therapy. In this study, Trx-1-overexpressing hucMSC-Trx-1 were obtained by adenoviral vector-mediated infection. We first measured the redox capacity of hucMSC-Trx-1 with an antioxidant capacity (T-AOC) assay, a hydrogen peroxide (H2O2) content determination assay in vivo, a H2O2-induced oxidation hemolysis assay, and a lipid peroxidation assay in vitro. Then, we measured survival time, the protection of the hematopoietic system, and the regulation of inflammation in important organs in three treatment groups of NOD/SCID mice (treated with hucMSC-Trx-1, with hucMSC, and with saline) that were exposed to 4.5 Gy (60)Co-γ-ray radiation. The hucMSC-Trx-1 group achieved superior antioxidation results, protecting bone marrow hematopoietic stem cells (Lin(-)CD117(+): hucMSC-Trx-1 vs. hucMSC, P<0.05; hucMSC-Trx-1 vs. NS, P<0.01), promoting the formation of red blood cells and hemoglobin (hucMSC-Trx-1 vs. hucMSC or NS, P<0.05), reducing inflammation and damage in important organs (Bone marrow and lung: hucMSC-Trx-1 vs. NS, P<0.01; hucMSC-Trx-1 vs. hucMSC, P<0.05. Liver and intestine: hucMSC-Trx-1 vs. NS, P<0.05; hucMSC-Trx-1 vs. hucMSC, P<0.05), and prolonging survival (hucMSC-Trx-1 vs. hucMSC or NS, P<0.01). Therefore, hucMSC-Trx-1 combines the merits of gene and cell therapy as a multifunctional radioprotector for ARI.

Atlas of Ohio Aquatic Insects: Volume II, Plecoptera.

PubMed

DeWalt, R Edward; Grubbs, Scott A; Armitage, Brian J; Baumann, Richard W; Clark, Shawn M; Bolton, Michael J

2016-01-01

We provide volume II of a distributional atlas of aquatic insects for the eastern USA state of Ohio. This treatment of stoneflies (Plecoptera) is companion to Armitage et al. (2011) on caddisflies (Trichoptera). We build on a recent analysis of Ohio stonefly diversity patterns based on large drainages (DeWalt et al. 2012), but add 3717 new records to the data set. We base most analyses on the United States Geological Survey Hierarchical Unit Code eight (HUC8) drainage scale. In addition to distributional maps for each species, we provide analyses of species richness versus HUC8 drainage area and the number of unique locations in a HUC8 drainage, species richness versus Ohio counties, analyze adult presence phenology throughout the year, and demonstrate stream size range affiliation for each species. This work is based on a total of 7797 specimen records gathered from 21 regional museums, agency data, personal collections, and from the literature Table 1. To our knowledge this is the largest stonefly data set available for a similarly sized geopolitical area anywhere in the world. These data are made available as a Darwin Core Archive supported by the Pensoft Integrated Publishing Toolkit (DeWalt et al. 2016b). All known published papers reporting stoneflies from Ohio are detailed in Suppl. material 1. We recovered 102 species from Ohio, including all nine Nearctic families Table 2​. Two species were removed from the DeWalt et al. (2012) list and two new state records added. Perlidae (32 spp.) was most speciose, compared to the low diversity Pteronarcyidae (2 spp.) and Peltoperlidae (1 sp.). The richest HUC8 drainages occurred in northeastern, south-central, and southern regions of the state where drainages were heavily forested, had the highest slopes, and were contained within or adjacent to the unglaciated Allegheny and Appalachian Plateaus. Species poor drainages occurred mainly in the northwestern region where Wisconsinan aged lake plains climaxed to an expansive wooded wetland, the Black Swamp. The unglaciated Lower Scioto drainage (72 spp.) in south-central Ohio supported the greatest species richness. There was no relationship between species richness and HUC8 drainage size, but the number of unique locations in a drainage strongly related to species richness. All Ohio counties were represented in the data set with Hocking County (59 spp.) of the Lower Scioto drainage being the richest and most heavily sampled. Adult presence phenology was influenced by phylogenetic relationships such that the superfamily Nemouroidea (Capniidae, Leuctridae, Nemouridae, and Taeniopterygidae) generally emerged in winter and spring while the superfamilies Pteronarcyoidea (Pteronarcyidae, Peltoperlidae) and Perloidea (Chloroperlidae, Perlidae, Perlodidae) emerged later, some species continuing emergence through summer months. Species often occupied specific stream size ranges, while others were generalists. Two species once histrorically abundant in the western Lake Erie Bass Islands no longer reside there. Each of the 102 species is discussed in detail, including several that require additional collecting efforts to confirm their identities, presence, and distribution in Ohio.

Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia.

PubMed

AlJohani, Roa'A; Polachek, Ari; Ye, Justine Yang; Chandran, Vinod; Gladman, Dafna D

2018-02-01

To determine the characteristics of patients with psoriatic arthritis (PsA) who have hyperuricemia (HUC) and their outcomes, especially cardiovascular (CVD) and kidney diseases. Patients have been followed prospectively at the PsA clinic according to a standard protocol at 6- to 12-month intervals. We defined HUC in men > 450 µ mol/l or women > 360 µ mol/l. We matched patients with HUC based on sex and age ± 5 years with normal uric acid patients. Demographics information and disease characteristics were reviewed. Outcomes of patients with HUC, especially CVD and kidney diseases, were recorded. Conditional logistic regression was performed to determine factors independently associated with HUC in patients with PsA. There were 325 (31.9%) out of 1019 patients with PsA who had HUC. Of these, 318 cases were matched to 318 controls. There were 11 (3.4%) out of 325 patients with HUC who had gout. Patients with HUC had longer disease duration and a higher Psoriasis Area and Severity Index. They had more concurrent comorbidities, including CVD and metabolic diseases, as well as higher prevalence of kidney stones and higher creatinine. Only 1 patient with HUC was treated with allopurinol at first evaluation visit and 7 patients during followup. Over the followup, 163 of the 318 patients had persistent HUC (pHUC) for more than 2 visits. Patients with pHUC developed more myocardial infarction, heart failure, and renal impairment. Multivariate analysis showed an association between pHUC, PsA disease duration, and obesity. HUC is common in patients with PsA, especially in those with longer disease duration and obesity. Proper control of HUC and metabolic diseases may play a preventive role in improving PsA outcomes.

3,3′-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing

PubMed Central

Shi, Hui; Xu, Xiao; Zhang, Bin; Xu, Jiahao; Pan, Zhaoji; Gong, Aihua; Zhang, Xu; Li, Rong; Sun, Yaoxiang; Yan, Yongmin; Mao, Fei; Qian, Hui; Xu, Wenrong

2017-01-01

Human umbilical cord-derived mesenchymal stem cells (hucMSCs) are suggested as a promising therapeutic tool in regenerative medicine, however, their efficacy requires improvement. Small molecules and drugs come up to be a convenient strategy in regulating stem cells fate and function. Here, we evaluated 3,3′-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model. HucMSCs primed with 50 μM of DIM exhibited desirable repairing effects compared with untreated hucMSCs. DIM enhanced the stemness of hucMSCs, which was related to the activation of Wnt/β-catenin signaling. β-catenin inhibition impaired the healing effects of DIM-primed hucMSCs (DIM-hucMSCs) in vivo. Moreover, we demonstrated that DIM upregulated Wnt11 expression in hucMSC-derived exosomes. Wnt11 knockdown inhibited β-catenin activation and stemness induction in DIM-hucMSCs and abrogated their therapeutic effects in vivo. Thus, our findings indicate that DIM promotes the stemness of hucMSCs through increased exosomal Wnt11 autocrine signaling, which provides a novel strategy for improving the therapeutic effects of hucMSCs on wound healing. PMID:28529644

WaterWatch - Maps, graphs, and tables of current, recent, and past streamflow conditions

USGS Publications Warehouse

Jian, Xiaodong; Wolock, David; Lins, Harry F.

2008-01-01

WaterWatch (http://water.usgs.gov/waterwatch/) is a U.S. Geological Survey (USGS) World Wide Web site that dis­plays maps, graphs, and tables describing real-time, recent, and past streamflow conditions for the United States. The real-time information generally is updated on an hourly basis. WaterWatch provides streamgage-based maps that show the location of more than 3,000 long-term (30 years or more) USGS streamgages; use colors to represent streamflow conditions compared to historical streamflow; feature a point-and-click interface allowing users to retrieve graphs of stream stage (water elevation) and flow; and highlight locations where extreme hydrologic events, such as floods and droughts, are occurring.The streamgage-based maps show streamflow conditions for real-time, average daily, and 7-day average streamflow. The real-time streamflow maps highlight flood and high flow conditions. The 7-day average streamflow maps highlight below-normal and drought conditions.WaterWatch also provides hydrologic unit code (HUC) maps. HUC-based maps are derived from the streamgage-based maps and illustrate streamflow conditions in hydrologic regions. These maps show average streamflow conditions for 1-, 7-, 14-, and 28-day periods, and for monthly average streamflow; highlight regions of low flow or hydrologic drought; and provide historical runoff and streamflow conditions beginning in 1901.WaterWatch summarizes streamflow conditions in a region (state or hydrologic unit) in terms of the long-term typical condition at streamgages in the region. Summary tables are provided along with time-series plots that depict variations through time. WaterWatch also includes tables of current streamflow information and locations of flooding.

Quantitative Microbial Risk Assessment Tutorial - Navigate the SDMPB and Identify an 8-digit HUC of Interest - Updated 2017

EPA Science Inventory

This tutorial reviews some of the screens, icons, and basic functions of the SDMProjectBuilder (SDMPB) that allow a user to identify an 8-digit HUC (HUC-8) of interest from which a pour point or 12-digit HUC (HUC-12) can be chosen for a microbial assessment. It demonstrates how t...

Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/β-Catenin Pathway

PubMed Central

Zhang, Bin; Wu, Xiaodan; Zhang, Xu; Sun, Yaoxiang; Yan, Yongmin; Shi, Hui; Zhu, Yanhua; Wu, Lijun; Pan, Zhaoji; Zhu, Wei

2015-01-01

Human umbilical cord mesenchymal stem cells (hucMSCs) and their exosomes have been considered as potential therapeutic tools for tissue regeneration; however, the underlying mechanisms are still not well understood. In this study, we isolated and characterized the exosomes from hucMSCs (hucMSC-Ex) and demonstrated that hucMSC-Ex promoted the proliferation, migration, and tube formation of endothelial cells in a dose-dependent manner. Furthermore, we demonstrated that hucMSC-Ex promoted wound healing and angiogenesis in vivo by using a rat skin burn model. We discovered that hucMSC-Ex promoted β-catenin nuclear translocation and induced the increased expression of proliferating cell nuclear antigen, cyclin D3, N-cadherin, and β-catenin and the decreased expression of E-cadherin. The activation of Wnt/β-catenin is critical in the induction of angiogenesis by hucMSC-Ex, which could be reversed by β-catenin inhibitor ICG-001. Wnt4 was delivered by hucMSC-Ex, and the knockdown of Wnt4 in hucMSC-Ex abrogated β-catenin nuclear translocation in endothelial cells. The in vivo proangiogenic effects were also inhibited by interference of Wnt4 expression in hucMSC-Ex. Taken together, these results suggest that hucMSC-Ex-mediated Wnt4 induces β-catenin activation in endothelial cells and exerts proangiogenic effects, which could be an important mechanism for cutaneous wound healing. PMID:25824139

EnviroAtlas - NatureServe Analysis of Imperiled or Federally Listed Species by HUC-12 for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset includes analysis by NatureServe of species that are Imperiled (G1/G2) or Listed under the U.S. Endangered Species Act (ESA) by 12-digit Hydrologic Units (HUCs). The analysis results are for use and publication by both the LandScope America website and by the EnviroAtlas. Results are provided for the total number of Aquatic Associated G1-G2/ESA species, the total number of Wetland Associated G1-G2/ESA species, the total number of Terrestrial Associated G1-G2/ESA species, and the total number of Unknown Habitat Association G1-G2/ESA species in each HUC12. NatureServe is a non-profit organization dedicated to developing and providing information about the world's plants, animals, and ecological communities. NatureServe works in partnership with 82 independent Natural Heritage programs and Conservation Data Centers that gather scientific information on rare species and ecosystems in the United States, Latin America, and Canada (the Natural Heritage Network). NatureServe is a leading source for biodiversity information that is essential for effective conservation action. This dataset was produced by NatureServe to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data

Atlas of Ohio Aquatic Insects: Volume II, Plecoptera

PubMed Central

Grubbs, Scott A.; Armitage, Brian J.; Baumann, Richard W.; Clark, Shawn M.; Bolton, Michael J.

2016-01-01

Abstract Background We provide volume II of a distributional atlas of aquatic insects for the eastern USA state of Ohio. This treatment of stoneflies (Plecoptera) is companion to Armitage et al. (2011) on caddisflies (Trichoptera). We build on a recent analysis of Ohio stonefly diversity patterns based on large drainages (DeWalt et al. 2012), but add 3717 new records to the data set. We base most analyses on the United States Geological Survey Hierarchical Unit Code eight (HUC8) drainage scale. In addition to distributional maps for each species, we provide analyses of species richness versus HUC8 drainage area and the number of unique locations in a HUC8 drainage, species richness versus Ohio counties, analyze adult presence phenology throughout the year, and demonstrate stream size range affiliation for each species. New information This work is based on a total of 7797 specimen records gathered from 21 regional museums, agency data, personal collections, and from the literature Table 1. To our knowledge this is the largest stonefly data set available for a similarly sized geopolitical area anywhere in the world. These data are made available as a Darwin Core Archive supported by the Pensoft Integrated Publishing Toolkit (DeWalt et al. 2016b). All known published papers reporting stoneflies from Ohio are detailed in Suppl. material 1. We recovered 102 species from Ohio, including all nine Nearctic families Table 2​. Two species were removed from the DeWalt et al. (2012) list and two new state records added. Perlidae (32 spp.) was most speciose, compared to the low diversity Pteronarcyidae (2 spp.) and Peltoperlidae (1 sp.). The richest HUC8 drainages occurred in northeastern, south-central, and southern regions of the state where drainages were heavily forested, had the highest slopes, and were contained within or adjacent to the unglaciated Allegheny and Appalachian Plateaus. Species poor drainages occurred mainly in the northwestern region where Wisconsinan aged lake plains climaxed to an expansive wooded wetland, the Black Swamp. The unglaciated Lower Scioto drainage (72 spp.) in south-central Ohio supported the greatest species richness. There was no relationship between species richness and HUC8 drainage size, but the number of unique locations in a drainage strongly related to species richness. All Ohio counties were represented in the data set with Hocking County (59 spp.) of the Lower Scioto drainage being the richest and most heavily sampled. Adult presence phenology was influenced by phylogenetic relationships such that the superfamily Nemouroidea (Capniidae, Leuctridae, Nemouridae, and Taeniopterygidae) generally emerged in winter and spring while the superfamilies Pteronarcyoidea (Pteronarcyidae, Peltoperlidae) and Perloidea (Chloroperlidae, Perlidae, Perlodidae) emerged later, some species continuing emergence through summer months. Species often occupied specific stream size ranges, while others were generalists. Two species once histrorically abundant in the western Lake Erie Bass Islands no longer reside there. Each of the 102 species is discussed in detail, including several that require additional collecting efforts to confirm their identities, presence, and distribution in Ohio. PMID:27932932

Distributed HUC-based modeling with SUMMA for ensemble streamflow forecasting over large regional domains.

NASA Astrophysics Data System (ADS)

Saharia, M.; Wood, A.; Clark, M. P.; Bennett, A.; Nijssen, B.; Clark, E.; Newman, A. J.

2017-12-01

Most operational streamflow forecasting systems rely on a forecaster-in-the-loop approach in which some parts of the forecast workflow require an experienced human forecaster. But this approach faces challenges surrounding process reproducibility, hindcasting capability, and extension to large domains. The operational hydrologic community is increasingly moving towards `over-the-loop' (completely automated) large-domain simulations yet recent developments indicate a widespread lack of community knowledge about the strengths and weaknesses of such systems for forecasting. A realistic representation of land surface hydrologic processes is a critical element for improving forecasts, but often comes at the substantial cost of forecast system agility and efficiency. While popular grid-based models support the distributed representation of land surface processes, intermediate-scale Hydrologic Unit Code (HUC)-based modeling could provide a more efficient and process-aligned spatial discretization, reducing the need for tradeoffs between model complexity and critical forecasting requirements such as ensemble methods and comprehensive model calibration. The National Center for Atmospheric Research is collaborating with the University of Washington, the Bureau of Reclamation and the USACE to implement, assess, and demonstrate real-time, over-the-loop distributed streamflow forecasting for several large western US river basins and regions. In this presentation, we present early results from short to medium range hydrologic and streamflow forecasts for the Pacific Northwest (PNW). We employ a real-time 1/16th degree daily ensemble model forcings as well as downscaled Global Ensemble Forecasting System (GEFS) meteorological forecasts. These datasets drive an intermediate-scale configuration of the Structure for Unifying Multiple Modeling Alternatives (SUMMA) model, which represents the PNW using over 11,700 HUCs. The system produces not only streamflow forecasts (using the MizuRoute channel routing tool) but also distributed model states such as soil moisture and snow water equivalent. We also describe challenges in distributed model-based forecasting, including the application and early results of real-time hydrologic data assimilation.

Ohio USA stoneflies (Insecta, Plecoptera): species richness estimation, distribution of functional niche traits, drainage affiliations, and relationships to other states

PubMed Central

DeWalt, R. Edward; Cao, Yong; Tweddale, Tari; Grubbs, Scott A.; Hinz, Leon; Pessino, Massimo; Robinson, Jason L.

2012-01-01

Abstract Ohio is an eastern USA state that historically was >70% covered in upland and mixed coniferous forest; about 60% of it glaciated by the Wisconsinan glacial episode. Its stonefly fauna has been studied in piecemeal fashion until now. The assemblage of Ohio stoneflies was assessed from over 4,000 records accumulated from 18 institutions, new collections, and trusted literature sources. Species richness totaled 102 with estimators Chao2 and ICE Mean predicting 105.6 and 106.4, respectively. Singletons and doubletons totaled 18 species. All North American families were represented with Perlidae accounted for the highest number of species at 34. The family Peltoperlidae contributed a single species. Most species had univoltine–fast life cycles with the vast majority emerging in summer, although there was a significant component of winter stoneflies. Nine United States Geological Survey hierarchical drainage units level 6 (HUC6) were used to stratify specimen data. Species richness was significantly related to the number of unique HUC6 locations, but there was no relationship with HUC6 drainage area. A nonparametric multidimensional scaling analysis found that larger HUC6s in the western part of the state had similar assemblages with lower species richness that were found to align with more savanna and wetland habitat. Other drainages having richer assemblages were aligned with upland deciduous and mixed coniferous forests of the east and south where slopes were higher. The Ohio assemblage was most similar to the well–studied fauna of Indiana (88 spp.) and Kentucky (108 spp.), two neighboring states. Many rare species and several high quality stream reaches should be considered for greater protection. PMID:22539876

The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts.

PubMed

Lisse, Thomas S; Vadivel, Kanagasabai; Bajaj, S Paul; Chun, Rene F; Hewison, Martin; Adams, John S

2014-01-01

Heterogeneous nuclear ribonucleoprotein (hnRNP) C plays a key role in RNA processing. More recently hnRNP C has also been shown to function as a DNA binding protein exerting a dominant-negative effect on transcriptional responses to the vitamin D hormone,1,25-dihydroxyvitamin D (1,25(OH) 2 D), via interaction in cis with vitamin D response elements (VDREs). The physiologically active form of human hnRNPC is a tetramer of hnRNPC1 (huC1) and C2 (huC2) subunits known to be critical for specific RNA binding activity in vivo , yet the requirement for heterodimerization of huC1 and C2 in DNA binding and downstream action is not well understood. While over-expression of either huC1 or huC2 alone in mouse osteoblastic cells did not suppress 1,25(OH) 2 D-induced transcription, over-expression of huC1 and huC2 in combination using a bone-specific polycistronic vector successfully suppressed 1,25(OH) 2 D-mediated induction of osteoblast target gene expression. Over-expression of either huC1 or huC2 in human osteoblasts was sufficient to confer suppression of 1,25(OH) 2 D-mediated transcription, indicating the ability of transfected huC1 and huC2 to successfully engage as heterodimerization partners with endogenously expressed huC1 and huC2. The failure of the chimeric combination of mouse and human hnRNPCs to impair 1,25(OH) 2 D-driven gene expression in mouse cells was structurally predicted, owing to the absence of the last helix in the leucine zipper (LZ) heterodimerization domain of hnRNPC gene product in lower species, including the mouse. These results confirm that species-specific heterodimerization of hnRNPC1 and hnRNPC2 is a necessary prerequisite for DNA binding and down-regulation of 1,25(OH) 2 D-VDR-VDRE-directed gene transactivation in osteoblasts.

A Large-Scale, High-Resolution Hydrological Model Parameter Data Set for Climate Change Impact Assessment for the Conterminous US

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oubeidillah, Abdoul A; Kao, Shih-Chieh; Ashfaq, Moetasim

2014-01-01

To extend geographical coverage, refine spatial resolution, and improve modeling efficiency, a computation- and data-intensive effort was conducted to organize a comprehensive hydrologic dataset with post-calibrated model parameters for hydro-climate impact assessment. Several key inputs for hydrologic simulation including meteorologic forcings, soil, land class, vegetation, and elevation were collected from multiple best-available data sources and organized for 2107 hydrologic subbasins (8-digit hydrologic units, HUC8s) in the conterminous United States at refined 1/24 (~4 km) spatial resolution. Using high-performance computing for intensive model calibration, a high-resolution parameter dataset was prepared for the macro-scale Variable Infiltration Capacity (VIC) hydrologic model. The VICmore » simulation was driven by DAYMET daily meteorological forcing and was calibrated against USGS WaterWatch monthly runoff observations for each HUC8. The results showed that this new parameter dataset may help reasonably simulate runoff at most US HUC8 subbasins. Based on this exhaustive calibration effort, it is now possible to accurately estimate the resources required for further model improvement across the entire conterminous United States. We anticipate that through this hydrologic parameter dataset, the repeated effort of fundamental data processing can be lessened, so that research efforts can emphasize the more challenging task of assessing climate change impacts. The pre-organized model parameter dataset will be provided to interested parties to support further hydro-climate impact assessment.« less

Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect.

PubMed

Jiang, Wenqian; Tan, Youwen; Cai, Mengjie; Zhao, Ting; Mao, Fei; Zhang, Xu; Xu, Wenrong; Yan, Zhixin; Qian, Hui; Yan, Yongmin

2018-01-01

Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30-100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. Human umbilical cord MSC-derived exosomes (hucMSC-Ex) play important roles in liver repair. However, the effects and mechanisms of hucMSC-Ex on liver injury development remain elusive. Mouse models of acute and chronic liver injury and liver tumor were induced by carbon tetrachloride (CCl 4 ) injection, followed by administration of hucMSC-Ex via the tail vein. Alleviation of liver injury by hucMSC-Ex was determined. We further explored the production of oxidative stress and apoptosis in the development of liver injury and compared the antioxidant effects of hucMSC-Ex with frequently used hepatic protectant, bifendate (DDB) in liver injury. hucMSC-Ex alleviated CCl 4 -induced acute liver injury and liver fibrosis and restrained the growth of liver tumors. Decreased oxidative stress and apoptosis were found in hucMSC-Ex-treated mouse models and liver cells. Compared to bifendate (DDB) treatment, hucMSC-Ex presented more distinct antioxidant and hepatoprotective effects. hucMSC-Ex may suppress CCl 4 -induced liver injury development via antioxidant potentials and could be a more effective antioxidant than DDB in CCl 4 -induced liver tumor development.

EnviroAtlas - Historic Places by 12-digit HUC for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset portrays the total number of historic places located within each 12-digit Hydrologic Unit (HUC). The historic places data were compiled from the National Park Service's National Register of Historic Places (NRHP), which provides official federal lists of districts, sites, buildings, structures and objects significant to American history, architecture, archeology, engineering, and culture. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

How Misapplication of the Hydrologic Unit Framework ...

EPA Pesticide Factsheets

Hydrologic units provide a convenient nationwide set of geographic polygons based on an arbitrary subdivision of the drainage of land surface areas at several hierarchical levels. Half or more of these units, however, are not true watersheds as the official name of the framework, Watershed Boundary Dataset (WBD), implies. Hydrologic units and watersheds are commonly treated as synonymous, and this misuse and misunderstanding can have some serious consequences. We discuss some of the strengths and limitations of watersheds and hydrologic units as spatial frameworks. Using examples from the Northwest and Southeast U.S., we explain how the misuse of the hydrologic unit framework has affected the meaning of watersheds and can impair the understanding of the associations of spatial geographic phenomena relative to a potentially infinite number of points on streams due to their linear nature. Watersheds are a fundamental geographic unit used to study the effects of natural and anthropogenic characteristics on the quality and quantity of water. Most scientists and resource managers historically have been in agreement on the spatial meaning of the term ‘watershed’ – that is, the topographic area within which water drains to a specific point on a stream, river, or particular waterbody. The Hydrologic Unit Code (HUC) framework, however, has changed this understanding. Hydrologic units provide a convenient nationwide set of geographic polygons based on an arbitra

Evaluation of the streamgage network for estimating streamflow statistics at ungaged sites in Pennsylvania and the Susquehanna River Basin in Pennsylvania and New York

USGS Publications Warehouse

Sloto, Ronald A.; Stuckey, Marla H.; Hoffman, Scott A.

2017-05-10

The current (2015) streamgage network in Pennsylvania and the Susquehanna River Basin in Pennsylvania and New York was evaluated in order to design a network that would meet the hydrologic needs of many partners and serve a variety of purposes and interests, including estimation of streamflow statistics at ungaged sites. This study was done by the U.S. Geological Survey, in cooperation with the Pennsylvania Department of Environmental Protection and the Susquehanna River Basin Commission. The study area includes the Commonwealth of Pennsylvania and the Susquehanna River Basin in Pennsylvania and New York. For this study, 229 streamgages were identified as reference streamgages that could be used to represent ungaged watersheds. Criteria for a reference streamgage are a minimum of 10 years of continuous record, minimally altered streamflow, and a drainage area less than 1,500 square miles. Some of the reference streamgages have been discontinued but provide historical hydrologic information valuable in the determination of streamflow characteristics of ungaged watersheds. Watersheds in the study area not adequately represented by a reference streamgage were identified by examining a range of basin characteristics, the extent of geographic coverage, and the strength of estimated streamflow correlations between gaged and ungaged sites.Basin characteristics were determined for the reference streamgage watersheds and the 1,662 12-digit hydrologic unit code (HUC12) subwatersheds in Pennsylvania and the Susquehanna River Basin using a geographic information system (GIS) spatial analysis and nationally available GIS datasets. Basin characteristics selected for this study include drainage area, mean basin elevation, mean basin slope, percentage of urbanized area, percentage of forested area, percentage of carbonate bedrock, mean annual precipitation, and soil thickness. A GIS spatial analysis was used to identify HUC12 subwatersheds outside the range of basin characteristics of the reference streamgages. There were 320 HUC12 subwatersheds, or 19 percent of the study area, with basin characteristics outside the range represented by the reference streamgage watersheds.A GIS spatial analysis was used to identify geographic gaps in the streamgage network. For each streamgage, a watershed area, called the gage statistical area (GSA), was delineated. The GSA shows the drainage area within a specific drainage-area ratio of the streamgage for transfer of streamflow statistics from that streamgage to ungaged sites on the valid statistical reach of the GSA for a streamgage. In Pennsylvania, a drainage-area ratio of 0.33–3 times the drainage area of the ungaged site was found to perform as well as, if not better than, more traditional ratios such as 0.5–1.5 (or 2) for transfer of selected streamflow statistics. A total of 1,102 HUC12 subwatersheds, or 66 percent of the study area, are outside the GSA for a reference streamgage.The USGS Baseline Streamflow Estimator (BaSE) program was used to determine how well HUC12 subwatersheds outside the streamgage GSAs are represented by the reference streamgage network in Pennsylvania, based on estimated streamflow correlation. The centroid of each HUC12 subwatershed was run through the BaSE program to determine the reference streamgage with the highest estimated streamflow correlation. There were 929 HUC12 subwatersheds in Pennsylvania, or 56 percent of the State, with an estimated correlation coefficient less than 0.96.The results from the basin characteristic, geographic, and streamflow correlation analyses were combined to identify 1,405 HUC12 subwatersheds in Pennsylvania and the Susquehanna River Basin in Pennsylvania and New York that lack a representative reference, based on at least one identified gap. Of the 1,405 HUC12 subwatersheds, 139 exhibited all three gaps, indicating a 8-percent gap in the reference streamgage network.Streamgages in areas with similar hydrologic characteristics and in close proximity to one another can potentially provide similar information (termed streamgages with high substitution potential). Streamgages were considered to have a high substitution potential with a nearby streamgage(s) if (1) the streamflow correlation coefficient was equal to or greater than 0.96, (2) the streamgages had 10 years of concurrent record, and (3) the streamgages are in the same watershed within the GSA of the streamgage. Seventy-four current (2015) streamgages with high substitution potential with at least one other streamgage were identified in the study area. Although these identified streamgages have a high substitution potential, they provide valuable streamflow information to a stakeholder. Selected primary uses of these streamgages were identified to determine the overall need for an individual streamgage.

A Compilation of Provisional Karst Geospatial Data for the Interior Low Plateaus Physiographic Region, Central United States

USGS Publications Warehouse

Taylor, Charles J.; Nelson, Hugh L.

2008-01-01

Geospatial data needed to visualize and evaluate the hydrogeologic framework and distribution of karst features in the Interior Low Plateaus physiographic region of the central United States were compiled during 2004-2007 as part of the Ground-Water Resources Program Karst Hydrology Initiative (KHI) project. Because of the potential usefulness to environmental and water-resources regulators, private consultants, academic researchers, and others, the geospatial data files created during the KHI project are being made available to the public as a provisional regional karst dataset. To enhance accessibility and visualization, the geospatial data files have been compiled as ESRI ArcReader data folders and user interactive Published Map Files (.pmf files), all of which are catalogued by the boundaries of surface watersheds using U.S. Geological Survey (USGS) eight-digit hydrologic unit codes (HUC-8s). Specific karst features included in the dataset include mapped sinkhole locations, sinking (or disappearing) streams, internally drained catchments, karst springs inventoried in the USGS National Water Information System (NWIS) database, relic stream valleys, and karst flow paths obtained from results of previously reported water-tracer tests.

Neoplastic transformation of SV40-immortalized human urinary tract epithelial cells by in vitro exposure to 3-methylcholanthrene.

PubMed

Reznikoff, C A; Loretz, L J; Christian, B J; Wu, S Q; Meisner, L F

1988-08-01

Normal human urinary tract epithelial cells (HUC) were neoplastically transformed in vitro using a step-wise strategy. First, a partially transformed non-virus-producing cell line was obtained after infection of HUC with simian virus 40 (SV40). This cell line (SV-HUC-1) was demonstrated to be clonal in origin, as 100% of cells contained at least five of seven marker chromosomes. Marker chromosomes were formed by balanced translocations resulting in a 'pseudodiploid' cell line. SV-HUC-1 showed altered growth properties in vitro (e.g. anchorage independent growth) but failed to form tumors in athymic nude mice, even after 3 years in culture (80 passages). In the studies reported here, SV-HUC-1 at early passages (P15-P19) were exposed to 3-methylcholanthrene (MCA) in three separate experiments. After a six-week post-treatment period of cell culture, cells were inoculated s.c. into athymic nude mice. In all experiments, MCA-treated SV-HUC-1 formed carcinomas in mice usually with a latent period of 5-8 weeks. These carcinomas showed heterogeneity with respect to histopathologies and growth properties in the mice and karyotypes. All the tumors retained SV-HUC-1 chromosome markers, but each independent transformant was aneuploid and contained unique new marker chromosomes. Chromosomes usually altered in tumor cells included numbers 3, 5, 6, 9, 11 and 13. Mutations in the ras family of cellular proto-oncogenes resulting in altered mobility of the p21 protein product were not detected in six cell lines established from independently derived tumors. It is not yet known whether other cellular proto-oncogenes are activated in these tumorigenic transformants. Neither control SV-HUC-1 (which were not exposed to MCA), nor early passage HUC exposed to MCA formed tumors when inoculated into mice. Thus, the tumorigenic transformation of HUC resulted from the combined actions of SV40 and MCA.

Quantitative Microbial Risk Assessment Tutorial: Navigate the SDMPB and Identify an 8-digit HUC of Interest

EPA Science Inventory

This tutorial reviews some of the screens, icons, and basic functions of the SDMProjectBuilder (SDMPB) that allow a user to identify a watershed of interest that can be used to choose a pour point or 12-digit HUC (HUC-12) for a microbial assessment. It demonstrates how to identif...

PisCES: Pis(cine) Community Estimation Software

EPA Science Inventory

PisCES predicts a fish community for any NHD-Plus stream reach in the conterminous United States. PisCES utilizes HUC-based distributional information for over 1,000 nature and non-native species obtained from NatureServe, the USGS, and Peterson Field Guide to Freshwater Fishes o...

Stream ecological condition modeling at the reach and the hydrologic unit (HUC) scale: A look at model performance and mapping

EPA Science Inventory

The National Hydrography and updated Watershed Boundary Datasets provide a ready-made framework for hydrographic modeling. Determining particular stream reaches or watersheds in poor ecological condition across large regions is an essential goal for monitoring and management. T...

Projecting water yield and ecosystem productivity across the United States by linking an ecohydrological model to WRF dynamically downscaled climate data

NASA Astrophysics Data System (ADS)

Sun, Shanlei; Sun, Ge; Cohen, Erika; McNulty, Steven G.; Caldwell, Peter V.; Duan, Kai; Zhang, Yang

2016-03-01

Quantifying the potential impacts of climate change on water yield and ecosystem productivity is essential to developing sound watershed restoration plans, and ecosystem adaptation and mitigation strategies. This study links an ecohydrological model (Water Supply and Stress Index, WaSSI) with WRF (Weather Research and Forecasting Model) using dynamically downscaled climate data of the HadCM3 model under the IPCC SRES A2 emission scenario. We evaluated the future (2031-2060) changes in evapotranspiration (ET), water yield (Q) and gross primary productivity (GPP) from the baseline period of 1979-2007 across the 82 773 watersheds (12-digit Hydrologic Unit Code level) in the coterminous US (CONUS). Across the CONUS, the future multi-year means show increases in annual precipitation (P) of 45 mm yr-1 (6 %), 1.8° C increase in temperature (T), 37 mm yr-1 (7 %) increase in ET, 9 mm yr-1 (3 %) increase in Q, and 106 gC m-2 yr-1 (9 %) increase in GPP. We found a large spatial variability in response to climate change across the CONUS 12-digit HUC watersheds, but in general, the majority would see consistent increases all variables evaluated. Over half of the watersheds, mostly found in the northeast and the southern part of the southwest, would see an increase in annual Q (> 100 mm yr-1 or 20 %). In addition, we also evaluated the future annual and monthly changes of hydrology and ecosystem productivity for the 18 Water Resource Regions (WRRs) or two-digit HUCs. The study provides an integrated method and example for comprehensive assessment of the potential impacts of climate change on watershed water balances and ecosystem productivity at high spatial and temporal resolutions. Results may be useful for policy-makers and land managers to formulate appropriate watershed-specific strategies for sustaining water and carbon sources in the face of climate change.

EnviroAtlas - Percentage of stream and water body shoreline lengths within 30 meters of >= 5% or >= 15% impervious cover by 12-Digit HUC for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset shows the percentages of stream and water body shoreline lengths within 30 meters of impervious cover by 12-digit Hydrologic Unit (HUC) subwatershed in the contiguous U.S. Impervious cover alters the hydrologic behavior of streams and water bodies, promoting increased storm water runoff and lower stream flow during periods in between rainfall events. Impervious cover also promotes increased pollutant loads in receiving waters and degraded streamside habitat. This dataset shows were impervious cover occurs close to streams and water bodies, where it is likely to have a greater adverse impact on receiving waters. This dataset was produced by the US EPA to support research and online mapping activities related to the EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Integrating Phosphorus Movement with Soil and Water Loss in the Daily Erosion Project

NASA Astrophysics Data System (ADS)

Sklenar, Tim; Perez-Bidegain, Mario; Cruse, Richard; Gelder, Brian; Herzmann, Daryl

2016-04-01

The Daily Erosion Project (DEP) is an ongoing modelling effort which is now in its second generation. DEP provides comprehensive and dynamic estimates of sediment delivery, soil erosion, and hill slope runoff for agricultural land areas across the Midwestern United States every day for Hydrologic Unit Code 12 (HUC 12) size watersheds. Results are posted every morning on the Internet at dailyerosion.org. Currently DEP covers all of Iowa and portions of Kansas and Minnesota, but expansion of coverage is ongoing. The integration of highly resolute spatial and temporal climate data, soil properties, crop rotation and residue management data affords the opportunity to test the effects of using multiple conservation practices on the transport and fate of water borne nutrients, especially phosphorus, on the Midwestern United States agricultural landscapes. Understanding the interaction of different environmental and land management practices on phosphorus movement will allow data from the DEP to guide conservation efforts as expansion continues into surrounding Midwestern states. The presentation will provide an overview of the DEP technology, including how input data are derived and used to make daily erosion estimates on over 200,000 flowpaths in the modelling area, as well as a discussion of the ongoing phosphorus transport modelling efforts and plans for future expansion (both land area and model functionality).

Concentrations, loads, and yields of total nitrogen and total phosphorus in the Barnegat Bay-Little Egg Harbor watershed, New Jersey, 1989-2011, at multiple spatial scales

USGS Publications Warehouse

Baker, Ronald J.; Wieben, Christine M.; Lathrop, Richard G.; Nicholson, Robert S.

2014-01-01

Concentrations, loads, and yields of nutrients (total nitrogen and total phosphorus) were calculated for the Barnegat Bay-Little Egg Harbor (BB-LEH) watershed for 1989–2011 at annual and seasonal (growing and nongrowing) time scales. Concentrations, loads, and yields were calculated at three spatial scales: for each of the 81 subbasins specified by 14-digit hydrologic unit codes (HUC-14s); for each of the three BB-LEH watershed segments, which coincide with segmentation of the BB-LEH estuary; and for the entire BB-LEH watershed. Base-flow and runoff values were calculated separately and were combined to provide total values. Available surface-water-quality data for all streams in the BB-LEH watershed for 1980–2011 were compiled from existing datasets and quality assured. Precipitation and streamflow data were used to distinguish between water-quality samples that were collected during base-flow conditions and those that were collected during runoff conditions. Base-flow separation of hydrographs of six streams in the BB-LEH watershed indicated that base flow accounts for about 72 to 94 percent of total flow in streams in the watershed. Base-flow mean concentrations (BMCs) of total nitrogen (TN) and total phosphorus (TP) for each HUC-14 subbasin were calculated from relations between land use and measured base-flow concentrations. These relations were developed from multiple linear regression models determined from water-quality data collected at sampling stations in the BB-LEH watershed under base-flow conditions and land-use percentages in the contributing drainage basins. The total watershed base-flow volume was estimated for each year and season from continuous streamflow records for 1989–2011 and relations between precipitation and streamflow during base-flow conditions. For each year and season, the base-flow load and yield were then calculated for each HUC-14 subbasin from the BMCs, total base-flow volume, and drainage area. The watershed-loading application PLOAD was used to calculate runoff concentrations, loads, and yields of TN and TP at the HUC-14 scale. Flow-weighted event-mean concentrations (EMCs) for runoff were developed for each major land-use type in the watershed using storm sampling data from four streams in the BB-LEH watershed and three streams outside the watershed. The EMCs were developed separately for the growing and nongrowing seasons, and were typically greater during the growing season. The EMCs, along with annual and seasonal precipitation amounts and percent imperviousness associated with land-use types, were used as inputs to PLOAD to calculate annual and seasonal runoff concentrations, loads, and yields at the HUC-14 scale. Over the period of study (1989–2011), total surface-water loads (base flow plus runoff) for the entire BB-LEH watershed for TN ranged from about 455,000 kilograms (kg) as N (1995) to 857,000 kg as N (2010). For TP, total loads for the watershed ranged from about 17,000 (1995) to 32,000 kg as P (2010). On average, the north segment accounted for about 66 percent of the annual TN load and 63 percent of the annual TP load, and the central and south segments each accounted for less than 20 percent of the nutrient loads. Loads and yields were strongly associated with precipitation patterns, ensuing hydrologic conditions, and land use. HUC-14 subbasins with the highest yields of nutrients are concentrated in the northern part of the watershed, and have the highest percentages of urban or agricultural land use. Subbasins with the lowest TN and TP yields are dominated by forest cover. Percentages of turf (lawn) cover and nonturf cover were estimated for the watershed. Of the developed land in the watershed, nearly one quarter (24.9 percent) was mapped as turf cover. Because there is a strong relation between percent turf and percent developed land, percent turf in the watershed typically increases with percent development, and the amount of development can be considered a reasonable predictor of the amount of turf cover in the watershed. In the BB-LEH watershed, calculated concentrations of TN and TP were greater for developed–turf areas than for developed–nonturf areas, which, in turn, were greater than those for undeveloped areas.

EnviroAtlas - NHDPlus V2 WBD Snapshot, EnviroAtlas version - Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset is a digital hydrologic unit boundary layer to the Subwatershed (12-digit) 6th level for the conterminous United States, based on the January 6, 2015 NHDPlus V2 WBD (Watershed Boundary Dataset) Snapshot (NHDPlusV21_NationalData_WBDSnapshot_FileGDB_05). The feature class has been edited for use in for EPA ORD's EnviroAtlas. Features in Canada and Mexico have been removed, the boundaries of three 12-digit HUCs have been edited to eliminate gaps and overlaps, the dataset has been dissolved on HUC_12 to create multipart polygons, and information on the percent land area has been added. Hawaii, Puerto Rico, and the U.S. Virgin Islands have been removed, and can be downloaded separately. Other than these modifications, the dataset is the same as the WBD Snapshot included in NHDPlus V2.This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Introduced Terrestrial Species Richness

EPA Pesticide Factsheets

These data represent predicted current distributions of all introduced mammals, birds, reptiles, amphibians and butterflies in the Middle-Atlantic region. These data are available for both 8-digit HUCs and EMAP hexagons. The data are species counts for each spatial unit. More information about these resources, including the variables used in this study, may be found here: https://edg.epa.gov/data/Public/ORD/NERL/ReVA/ReVA_Data.zip.

Native Terrestrial Animal Species Richness

EPA Pesticide Factsheets

These data represent predicted current distributions of all native mammals, birds, reptiles, amphibians and butterflies in the Middle-Atlantic region. The data are available for both 8-digit HUCs and EMAP hexagons and represent total species counts for each spatial unit. More information about these resources, including the variables used in this study, may be found here: https://edg.epa.gov/data/Public/ORD/NERL/ReVA/ReVA_Data.zip.

Agricultural conservation planning framework: 1. Developing multipractice watershed planning scenarios and assessing nutrient reduction potential.

PubMed

Tomer, M D; Porter, S A; Boomer, K M B; James, D E; Kostel, J A; Helmers, M J; Isenhart, T M; McLellan, E

2015-05-01

Spatial data on soils, land use, and topography, combined with knowledge of conservation effectiveness, can be used to identify alternatives to reduce nutrient discharge from small (hydrologic unit code [HUC]12) watersheds. Databases comprising soil attributes, agricultural land use, and light detection and ranging-derived elevation models were developed for two glaciated midwestern HUC12 watersheds: Iowa's Beaver Creek watershed has an older dissected landscape, and Lime Creek in Illinois is young and less dissected. Subsurface drainage is common in both watersheds. We identified locations for conservation practices, including in-field practices (grassed waterways), edge-of-field practices (nutrient-removal wetlands, saturated buffers), and drainage-water management, by applying terrain analyses, geographic criteria, and cross-classifications to field- and watershed-scale geographic data. Cover crops were randomly distributed to fields without geographic prioritization. A set of alternative planning scenarios was developed to represent a variety of extents of implementation among these practices. The scenarios were assessed for nutrient reduction potential using a spreadsheet approach to calculate the average nutrient-removal efficiency required among the practices included in each scenario to achieve a 40% NO-N reduction. Results were evaluated in the context of the Iowa Nutrient Reduction Strategy, which reviewed nutrient-removal efficiencies of practices and established the 40% NO-N reduction as Iowa's target for Gulf of Mexico hypoxia mitigation by agriculture. In both test watersheds, planning scenarios that could potentially achieve the targeted NO-N reduction but remove <5% of cropland from production were identified. Cover crops and nutrient removal wetlands were common to these scenarios. This approach provides an interim technology to assist local watershed planning and could provide planning scenarios to evaluate using watershed simulation models. A set of ArcGIS tools is being released to enable transfer of this mapping technology. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Increased baseflow in Iowa over the second half of the 20th Century

USGS Publications Warehouse

Schilling, K.E.; Libra, R.D.

2003-01-01

Historical trends in annual discharge characteristics were evaluated for 11 gauging stations located throughout Iowa. Discharge records from nine eight-digit hydrologic unit code (HUC-8) watersheds were examined for the period 1940 to 2000, whereas data for two larger river systems (Cedar and Des Moines Rivers) were examined for a longer period of record (1903 to 2000). In nearly all watersheds evaluated, annual baseflow, annual minimum flow, and the annual baseflow percentage significantly increased over time. Some rivers also exhibited increasing trends in total annual discharge, whereas only the Maquoketa River had significantly decreased annual maximum flows. Regression of stream discharge versus precipitation indicated that more precipitation is being routed into streams as baseflow than as stormflow in the second half of the 20th Century. Reasons for the observed streamflow trends are hypothesized to include improved conservation practices, greater artificial drainage, increasing row crop production, and channel incision. Each of these reasons is consistent with the observed trends, and all are likely responsible to some degree in most watersheds.

Statistical classification of hydrogeologic regions in the fractured rock area of Maryland and parts of the District of Columbia, Virginia, West Virginia, Pennsylvania, and Delaware

USGS Publications Warehouse

Fleming, Brandon J.; LaMotte, Andrew E.; Sekellick, Andrew J.

2013-01-01

Hydrogeologic regions in the fractured rock area of Maryland were classified using geographic information system tools with principal components and cluster analyses. A study area consisting of the 8-digit Hydrologic Unit Code (HUC) watersheds with rivers that flow through the fractured rock area of Maryland and bounded by the Fall Line was further subdivided into 21,431 catchments from the National Hydrography Dataset Plus. The catchments were then used as a common hydrologic unit to compile relevant climatic, topographic, and geologic variables. A principal components analysis was performed on 10 input variables, and 4 principal components that accounted for 83 percent of the variability in the original data were identified. A subsequent cluster analysis grouped the catchments based on four principal component scores into six hydrogeologic regions. Two crystalline rock hydrogeologic regions, including large parts of the Washington, D.C. and Baltimore metropolitan regions that represent over 50 percent of the fractured rock area of Maryland, are distinguished by differences in recharge, Precipitation minus Potential Evapotranspiration, sand content in soils, and groundwater contributions to streams. This classification system will provide a georeferenced digital hydrogeologic framework for future investigations of groundwater availability in the fractured rock area of Maryland.

HUC--A User Designed System for All Recorded Knowledge and Information.

ERIC Educational Resources Information Center

Hilton, Howard J.

This paper proposes a user designed system, HUC, intended to provide a single index and retrieval system covering all recorded knowledge and information capable of being retrieved from all modes of storage, from manual to the most sophisticated retrieval system. The concept integrates terminal hardware, software, and database structure to allow…

Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells.

PubMed

Li, Ruomei; Sharma, Biswa Nath; Linder, Stig; Gutteberg, Tore Jarl; Hirsch, Hans H; Rinaldo, Christine Hanssen

2013-05-25

High-level polyomavirus BK (BKPyV) replication in urothelial cells is a hallmark of polyomavirus-associated hemorrhagic cystitis (PyVHC), a painful condition affecting bone marrow transplant recipients. In kidney transplant recipients, replication in tubular epithelial cells is associated with overt disease whereas high-level urothelial replication is clinically silent. We characterized BKPyV replication in primary human urothelial cells (HUCs) and compared it to replication in renal tubular epithelial cells (RPTECs). HUCs were easily infected, as shown by expression of T-antigens, VP1-3, and agnoprotein, and intranuclear virion production. Compared to RPTECs, progeny release was delayed by ≥24h and reduced. BKPyV-infected HUCs rounded up like "decoy cells" and detached without necrosis as shown by delayed cytokeratin-18 release, real-time viability monitoring and imaging. The data show that BKV infection of HUCs and RPTECs is significantly different and support the notion that PyVHC pathogenesis is not solely due to BKPyV replication, but likely requires urotoxic and immunological cofactors. Copyright © 2013 Elsevier Inc. All rights reserved.

Threatened and Endangered Terrestrial Animal Species Richness

EPA Pesticide Factsheets

These data represent predicted current distributions of all U.S. listed threatened and endangered mammals, birds, reptiles, and amphibians in the Middle-Atlantic region. The data are available for both 8-digit HUCs and EMAP hexagons and represent total species counts for each spatial unit. More information about these resources, including the variables used in this study, may be found here: https://edg.epa.gov/data/Public/ORD/NERL/ReVA/ReVA_Data.zip.

Modulated Raman spectroscopy for enhanced identification of bladder tumor cells in urine samples.

PubMed

Canetta, Elisabetta; Mazilu, Michael; De Luca, Anna Chiara; Carruthers, Antonia E; Dholakia, Kishan; Neilson, Sam; Sargeant, Harry; Briscoe, Tina; Herrington, C Simon; Riches, Andrew C

2011-03-01

Standard Raman spectroscopy (SRS) is a noninvasive technique that is used in the biomedical field to discriminate between normal and cancer cells. However, the presence of a strong fluorescence background detracts from the use of SRS in real-time clinical applications. Recently, we have reported a novel modulated Raman spectroscopy (MRS) technique to extract the Raman spectra from the background. In this paper, we present the first application of MRS to the identification of human urothelial cells (SV-HUC-1) and bladder cancer cells (MGH) in urine samples. These results are compared to those obtained by SRS. Classification using the principal component analysis clearly shows that MRS allows discrimination between Raman spectra of SV-HUC-1 and MGH cells with high sensitivity (98%) and specificity (95%). MRS is also used to distinguish between SV-HUC-1 and MGH cells after exposure to urine for up to 6 h. We observe a marked change in the MRS of SV-HUC-1 and MGH cells with time in urine, indicating that the conditions of sample collection will be important for the application of this methodology to clinical urine samples.

EnviroAtlas - Synthetic N fertilizer application to agricultural lands by 12-digit HUC in the Conterminous United States, 2006

EPA Pesticide Factsheets

This EnviroAtlas dataset contains data on the mean synthetic nitrogen (N) fertilizer application to cultivated crop and hay/pasture lands per 12-digit Hydrologic Unit (HUC) in 2006. Synthetic N fertilizer inputs in 2006 were estimated using county-level estimates of farm N fertilizer inputs. We acquired county-level data describing total farm-level inputs (kg N/yr) of synthetic N fertilizer to individual counties in 2006 from the United States Geological Survey (USGS) (http://pubs.usgs.gov/sir/2012/5207/). These data were converted to per area rates (kg N/ha/yr) of synthetic N fertilizer application by dividing the total N input by the land area (ha) of combined cultivated crop and hay/pasture lands within a county as determined from county-level (http://cta.ornl.gov/transnet/Boundaries.html) summarization of the 2006 National Land Cover Database (NLCD; http://www.mrlc.gov/nlcd06_data.php). We distributed county-specific, annual per area N inputs rates (kg N/ha/yr) to cultivated crop and hay/pasture lands (30 x 30 m pixels) within the corresponding county using the raster calculator tool in ArcMap 10.0 (ESRI, Inc., Redlands, CA). Fertilizer data described here represent an average input to a typical agricultural land type within a county, i.e., they are not specific to individual crop types. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the us

Nasopharyngeal Pneumococcal Colonization and Impact of a Single Dose of 13-Valent Pneumococcal Conjugate Vaccine in Indian Children With HIV and Their Unvaccinated Parents.

PubMed

Arya, Bikas K; Bhattacharya, Sangeeta Das; Sutcliffe, Catherine G; Ganaie, Feroze; Bhaskar, Arun; Bhattacharyya, Subhasish; Niyogi, Swapan Kumar; Moss, William J; Panda, Samiran; Ravikumar, Kadahalli Lingegowda; Das, Ranjan Saurav; Mandal, Sutapa

2018-05-01

Human immunodeficiency virus (HIV) infection increases risk of invasive disease from Streptococcus pneumoniae. Pneumococcal conjugate vaccines (PCV) prevent invasive disease and acquisition of vaccine type (VT) pneumococcus in the nasopharynx. To look at the safety and impact of one dose of PCV13 on acquisition of VT pneumococcal carriage in Indian children with HIV. We conducted a cohort study in families of HIV-infected children (CLH) and families of HIV-uninfected children (HUC) in West Bengal. All children received one dose of PCV13. Nasopharyngeal swabs were collected from children and parents at baseline and 2 months after vaccination. One hundred and fifteen CLH and 47 HUC received one dose of PCV13. Fifty-eight percent of CLH were on antiretroviral therapy (ART), and the median nadir CD4 count was 287. There were no significant adverse events in either group. HUC had more VT colonization than CLH-55% versus 23% of all pneumococcal isolates. HIV infection doubled the risk of nonvaccine serotype colonization (P = 0.03). There was no difference in acquisition of VT isolates in CLH (4.4%) and HUC (4.5%) post-PCV13; however, older CLH (>5 years) had decreased clearance of VT strains. ART made no difference in pneumococcal colonization at baseline or after PCV13; however, CLH with higher nadir CD4 counts before starting ART were less likely to have VT colonization post-PCV13 (prevalence ratio, 0.2; 95% confidence interval: 0.1-0.5). While there was no difference in acquisition of VT nasopharyngeal carriage of pneumococcus in CLH and HUC after one dose of PCV13, earlier access to ART may impact response to PCV13 in CLH.

Discrimination of bladder cancer cells from normal urothelial cells with high specificity and sensitivity: combined application of atomic force microscopy and modulated Raman spectroscopy.

PubMed

Canetta, Elisabetta; Riches, Andrew; Borger, Eva; Herrington, Simon; Dholakia, Kishan; Adya, Ashok K

2014-05-01

Atomic force microscopy (AFM) and modulated Raman spectroscopy (MRS) were used to discriminate between living normal human urothelial cells (SV-HUC-1) and bladder tumour cells (MGH-U1) with high specificity and sensitivity. MGH-U1 cells were 1.5-fold smaller, 1.7-fold thicker and 1.4-fold rougher than normal SV-HUC-1 cells. The adhesion energy was 2.6-fold higher in the MGH-U1 cells compared to normal SV-HUC-1 cells, which possibly indicates that bladder tumour cells are more deformable than normal cells. The elastic modulus of MGH-U1 cells was 12-fold lower than SV-HUC-1 cells, suggesting a higher elasticity of the bladder cancer cell membranes. The biochemical fingerprints of cancer cells displayed a higher DNA and lipid content, probably due to an increase in the nuclear to cytoplasm ratio. Normal cells were characterized by higher protein contents. AFM studies revealed a decrease in the lateral dimensions and an increase in thickness of cancer cells compared to normal cells; these studies authenticate the observations from MRS. Nanostructural, nanomechanical and biochemical profiles of bladder cells provide qualitative and quantitative markers to differentiate between normal and cancerous cells at the single cellular level. AFM and MRS allow discrimination between adhesion energy, elasticity and Raman spectra of SV-HUC-1 and MGH-U1 cells with high specificity (83, 98 and 95%) and sensitivity (97, 93 and 98%). Such single-cell-level studies could have a pivotal impact on the development of AFM-Raman combined methodologies for cancer profiling and screening with translational significance. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Application of a three-tier framework to assess ecological condition of Gulf of Mexico coastal wetlands.

PubMed

Nestlerode, Janet A; Hansen, Virginia D; Teague, Aarin; Harwell, Matthew C

2014-06-01

A multi-level coastal wetland assessment strategy was applied to wetlands in the northern Gulf of Mexico (GOM) to evaluate the feasibility of this approach for a broad national scale wetland condition assessment (US Environmental Protection Agency's National Wetlands Condition Assessment). Landscape-scale assessment indicators (tier 1) were developed and applied at the sub-watershed (12-digit hydrologic unit code (HUC)) level within the GOM coastal wetland sample frame with scores calculated using land-use maps and geographic information system. Rapid assessment protocols (tier 2), using a combination of data analysis and field work, evaluated metrics associated with landscape context, hydrology, physical structure, and biological structure. Intensive site monitoring (tier 3) included measures of soil chemistry and composition, water column and pore-water chemistry, and dominant macrophyte community composition and tissue chemistry. Relationships within and among assessment levels were evaluated using multivariate analyses with few significant correlations found. More detailed measures of hydrology, soils, and macrophyte species composition from sites across a known condition gradient, in conjunction with validation of standardized rapid assessment method, may be necessary to fully characterize coastal wetlands across the region.

EnviroAtlas - Manure application to agricultural lands from confined animal feeding operations by 12-digit HUC for the Conterminous United States, 2006

EPA Pesticide Factsheets

This EnviroAtlas dataset contains data on the mean livestock manure application to cultivated crop and hay/pasture lands by 12-digit Hydrologic Unit (HUC) in 2006. Livestock manure inputs to cultivated crop and hay/pasture lands were estimated using county-level estimates of recoverable animal manure from confined feeding operations compiled for 2007. Recoverable manure is defined as manure that is collected, stored, and available for land application from confined feeding operations. County-scale data on livestock populations -- needed to calculate manure inputs -- were only available for the year 2007 from the USDA Census of Agriculture (http://www.agcensus.usda.gov/index.php). We acquired county-level data describing total farm-level inputs (kg N/yr) of recoverable manure to individual counties in 2007 from the International Plant Nutrition Institute (IPNI) Nutrient Geographic Information System (NuGIS; http://www.ipni.net/nugis). These data were converted to per area rates (kg N/ha/yr) of manure N inputs by dividing the total N input by the land area (ha) of combined cultivated crop and hay/pasture (agricultural) lands within a county as determined from county-level summarization of the 2006 NLCD. We distributed county-specific, per area N inputs rates to cultivated crop and hay/pasture lands (30 x 30 m pixels) within the corresponding county. Manure data described here represent an average input to a typical agricultural land type within a county, i.e., the

EnviroAtlas - Atmospheric Nitrogen Deposition by 12-digit HUC for the Conterminous United States (2002)

EPA Pesticide Factsheets

This EnviroAtlas dataset includes annual nitrogen and sulfur deposition within each 12-digit HUC subwatershed for the year 2002. Values are provided for total oxidized nitrogen (HNO3, NO, NO2, N2O5, NH3, HONO, PAN, organic nitrogen, and particulate NO3), oxidized nitrogen wet deposition, oxidized nitrogen dry deposition, total reduced nitrogen (NH3 and particulate NH4), reduced nitrogen dry deposition, reduced nitrogen wet deposition, total dry nitrogen deposition, total wet nitrogen deposition, total nitrogen deposition (wet+dry), total sulfur (SO2 + particulate SO4) dry deposition, total sulfur wet deposition, and total sulfur deposition. The dataset is based on output from the Community Multiscale Air Quality modeling system (CMAQ) v5.0.2 run using the bidirectional flux option for the 12-km grid size for the US, Canada, and Mexico. The CMAQ output has been post-processed to adjust the wet deposition for errors in the location and amount of precipitation and for regional biases in the TNO3 (HNO3 + NO3), NHx (NH4 + NH3), and sulfate wet deposition. Model predicted values of dry deposition were not adjusted. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadab

EnviroAtlas - Atmospheric Nitrogen and Sulfur Deposition by 12-digit HUC for the Conterminous United States (2011)

EPA Pesticide Factsheets

This EnviroAtlas dataset includes annual nitrogen and sulfur deposition within each 12-digit HUC subwatershed for the year 2011. Values are provided for total oxidized nitrogen (HNO3, NO, NO2, N2O5, NH3, HONO, PAN, organic nitrogen, and particulate NO3), oxidized nitrogen wet deposition, oxidized nitrogen dry deposition, total reduced nitrogen (NH3 and particulate NH4), reduced nitrogen dry deposition, reduced nitrogen wet deposition, total dry nitrogen deposition, total wet nitrogen deposition, total nitrogen deposition (wet+dry), total sulfur (SO2 + particulate SO4) dry deposition, total sulfur wet deposition, and total sulfur deposition. The dataset is based on output from the Community Multiscale Air Quality modeling system (CMAQ) run using the bidirectional flux option for the 12-km grid size for the US, Canada, and Mexico. The CMAQ output has been post-processed to adjust the wet deposition for errors in the location and amount of precipitation and for regional biases in the TNO3 (HNO3 + NO3), NHx (NH4 + NH3), and sulfate wet deposition. Model predicted values of dry deposition were not adjusted. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data

EnviroAtlas - Atmospheric Nitrogen Deposition by 12-digit HUC for the Conterminous United States (2006)

EPA Pesticide Factsheets

This EnviroAtlas dataset includes annual nitrogen and sulfur deposition within each 12-digit HUC subwatershed for the year 2006. Values are provided for total oxidized nitrogen (HNO3, NO, NO2, N2O5, NH3, HONO, PAN, organic nitrogen, and particulate NO3), oxidized nitrogen wet deposition, oxidized nitrogen dry deposition, total reduced nitrogen (NH3 and particulate NH4), reduced nitrogen dry deposition, reduced nitrogen wet deposition, total dry nitrogen deposition, total wet nitrogen deposition, total nitrogen deposition (wet+dry), total sulfur (SO2 + particulate SO4) dry deposition, total sulfur wet deposition, and total sulfur deposition. The dataset is based on output from the Community Multiscale Air Quality modeling system (CMAQ) run using the bidirectional flux option for the 12-km grid size for the US, Canada, and Mexico. The CMAQ output has been post-processed to adjust the wet deposition for errors in the location and amount of precipitation and for regional biases in the TNO3 (HNO3 + NO3), NHx (NH4 + NH3), and sulfate wet deposition. Model predicted values of dry deposition were not adjusted. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable dat

Python tools for rapid development, calibration, and analysis of generalized groundwater-flow models

NASA Astrophysics Data System (ADS)

Starn, J. J.; Belitz, K.

2014-12-01

National-scale water-quality data sets for the United States have been available for several decades; however, groundwater models to interpret these data are available for only a small percentage of the country. Generalized models may be adequate to explain and project groundwater-quality trends at the national scale by using regional scale models (defined as watersheds at or between the HUC-6 and HUC-8 levels). Coast-to-coast data such as the National Hydrologic Dataset Plus (NHD+) make it possible to extract the basic building blocks for a model anywhere in the country. IPython notebooks have been developed to automate the creation of generalized groundwater-flow models from the NHD+. The notebook format allows rapid testing of methods for model creation, calibration, and analysis. Capabilities within the Python ecosystem greatly speed up the development and testing of algorithms. GeoPandas is used for very efficient geospatial processing. Raster processing includes the Geospatial Data Abstraction Library and image processing tools. Model creation is made possible through Flopy, a versatile input and output writer for several MODFLOW-based flow and transport model codes. Interpolation, integration, and map plotting included in the standard Python tool stack also are used, making the notebook a comprehensive platform within on to build and evaluate general models. Models with alternative boundary conditions, number of layers, and cell spacing can be tested against one another and evaluated by using water-quality data. Novel calibration criteria were developed by comparing modeled heads to land-surface and surface-water elevations. Information, such as predicted age distributions, can be extracted from general models and tested for its ability to explain water-quality trends. Groundwater ages then can be correlated with horizontal and vertical hydrologic position, a relation that can be used for statistical assessment of likely groundwater-quality conditions. Convolution with age distributions can be used to quickly ascertain likely future water-quality conditions. Although these models are admittedly very general and are still being tested, the hope is that they will be useful for answering questions related to water quality at the regional scale.

EnviroAtlas - Cultivated biological nitrogen fixation in agricultural lands by 12-digit HUC in the Conterminous United States, 2006

EPA Pesticide Factsheets

This EnviroAtlas dataset contains data on the mean cultivated biological nitrogen fixation (C-BNF) in cultivated crop and hay/pasture lands per 12-digit Hydrologic Unit (HUC) in 2006. Nitrogen (N) inputs from the cultivation of legumes, which possess a symbiotic relationship with N-fixing bacteria, were calculated with a recently developed model relating county-level yields of various leguminous crops with BNF rates. We accessed county-level data on annual crop yields for soybeans (Glycine max L.), alfalfa (Medicago sativa L.), peanuts (Arachis hypogaea L.), various dry beans (Phaseolus, Cicer, and Lens spp.), and dry peas (Pisum spp.) for 2006 from the USDA Census of Agriculture (http://www.agcensus.usda.gov/index.php). We estimated the yield of the non-alfalfa leguminous component of hay as 32% of the yield of total non-alfalfa hay (http://www.agcensus.usda.gov/index.php). Annual rates of C-BNF by crop type were calculated using a model that relates yield to C-BNF. We assume yield data reflect differences in soil properties, water availability, temperature, and other local and regional factors that can influence root nodulation and rate of N fixation. We distributed county-specific, C-BNF rates to cultivated crop and hay/pasture lands delineated in the 2006 National Land Cover Database (30 x 30 m pixels) within the corresponding county. C-BNF data described here represent an average input to a typical agricultural land type within a county, i.e., they are not

Involvement of epigenetics and EMT related miRNA in arsenic induced neoplastic transformation and their potential clinical use

PubMed Central

Michailidi, Christina; Hayashi, Masamichi; Datta, Sayantan; Sen, Tanusree; Zenner, Kaitlyn; Oladeru, Oluwadamilola; Brait, Mariana; Izumchenko, Evgeny; Baras, Alexander; VandenBussche, Christopher; Argos, Maria; Bivalacqua, Trinity J; Ahsan, Habibul; Hahn, Noah M.; Netto, George J.; Sidransky, David; Hoque, Mohammad O.

2015-01-01

Exposure to toxicants leads to cumulative molecular changes that overtime increase a subject’s risk of developing urothelial carcinoma (UC). To assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model and tested a panel of miRNAs in urine samples from arsenic exposed subjects, UC patients and controls. To prepare an in vitro model, we chronically exposed an immortalized normal human bladder cell line (HUC1) to arsenic. Growth of the HUC1 cells was increased in a time dependent manner after arsenic treatment and cellular morphology was changed. In soft agar assay, colonies were observed only in arsenic treated cells and the number of colonies gradually increased with longer periods of treatment. Similarly, invaded cells in invasion assay were observed only in arsenic treated cells. Withdrawal of arsenic treatment for 2.5 months did not reverse the tumorigenic properties of arsenic treated cells. Western blot analysis demonstrated decreased PTEN and increased AKT and mTOR in arsenic treated HUC1 cells. Levels of miR-200a, miR-200b, and miR-200c were down-regulated in arsenic exposed HUC1 cells by quantitative RT-PCR. Furthermore, in human urine, miR-200c and miR-205 were inversely associated with arsenic exposure (P=0.005 and 0.009, respectively). Expression of miR-205 discriminated cancer cases from controls with high sensitivity and specificity (AUC=0.845). Our study suggests that exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of arsenic exposure as well as a maker of early UC detection. PMID:25586904

Characterizing and optimizing poly-l-lactide-co-ε-caprolactone membranes for urothelial tissue engineering

PubMed Central

Sartoneva, Reetta; Haaparanta, Anne-Marie; Lahdes-Vasama, Tuija; Mannerström, Bettina; Kellomäki, Minna; Salomäki, Minna; Sándor, George; Seppänen, Riitta; Miettinen, Susanna; Haimi, Suvi

2012-01-01

Different synthetic biomaterials such as polylactide (PLA), polycaprolactone and poly-l-lactide-co-ε-caprolactone (PLCL) have been studied for urothelial tissue engineering, with favourable results. The aim of this research was to further optimize the growth surface for human urothelial cells (hUCs) by comparing different PLCL-based membranes: smooth (s) and textured (t) PLCL and knitted PLA mesh with compression-moulded PLCL (cPLCL). The effects of topographical texturing on urothelial cell response and mechanical properties under hydrolysis were studied. The main finding was that both sPLCL and tPLCL supported hUC growth significantly better than cPLCL. Interestingly, tPLCL gave no significant advantage to hUC attachment or proliferation compared with sPLCL. However, during the 14 day assessment period, the majority of cells were viable and maintained phenotype on all the membranes studied. The material characterization exhibited potential mechanical characteristics of sPLCL and tPLCL for urothelial applications. Furthermore, the highest elongation of tPLCL supports the use of this kind of texturing. In conclusion, in light of our cell culture results and mechanical characterization, both sPLCL and tPLCL should be further studied for urothelial tissue engineering. PMID:22896571

Seasonal hydrologic responses to climate change in the Pacific Northwest

NASA Astrophysics Data System (ADS)

Vano, Julie A.; Nijssen, Bart; Lettenmaier, Dennis P.

2015-04-01

Increased temperatures and changes in precipitation will result in fundamental changes in the seasonal distribution of streamflow in the Pacific Northwest and will have serious implications for water resources management. To better understand local impacts of regional climate change, we conducted model experiments to determine hydrologic sensitivities of annual, seasonal, and monthly runoff to imposed annual and seasonal changes in precipitation and temperature. We used the Variable Infiltration Capacity (VIC) land-surface hydrology model applied at 1/16° latitude-longitude spatial resolution over the Pacific Northwest (PNW), a scale sufficient to support analyses at the hydrologic unit code eight (HUC-8) basin level. These experiments resolve the spatial character of the sensitivity of future water supply to precipitation and temperature changes by identifying the seasons and locations where climate change will have the biggest impact on runoff. The PNW exhibited a diversity of responses, where transitional (intermediate elevation) watersheds experience the greatest seasonal shifts in runoff in response to cool season warming. We also developed a methodology that uses these hydrologic sensitivities as basin-specific transfer functions to estimate future changes in long-term mean monthly hydrographs directly from climate model output of precipitation and temperature. When principles of linearity and superposition apply, these transfer functions can provide feasible first-order estimates of the likely nature of future seasonal streamflow change without performing downscaling and detailed model simulations.

The Virtual Watershed Observatory: Cyberinfrastructure for Model-Data Integration and Access

NASA Astrophysics Data System (ADS)

Duffy, C.; Leonard, L. N.; Giles, L.; Bhatt, G.; Yu, X.

2011-12-01

The Virtual Watershed Observatory (VWO) is a concept where scientists, water managers, educators and the general public can create a virtual observatory from integrated hydrologic model results, national databases and historical or real-time observations via web services. In this paper, we propose a prototype for automated and virtualized web services software using national data products for climate reanalysis, soils, geology, terrain and land cover. The VWO has the broad purpose of making accessible water resource simulations, real-time data assimilation, calibration and archival at the scale of HUC 12 watersheds (Hydrologic Unit Code) anywhere in the continental US. Our prototype for model-data integration focuses on creating tools for fast data storage from selected national databases, as well as the computational resources necessary for a dynamic, distributed watershed simulation. The paper will describe cyberinfrastructure tools and workflow that attempts to resolve the problem of model-data accessibility and scalability such that individuals, research teams, managers and educators can create a WVO in a desired context. Examples are given for the NSF-funded Shale Hills Critical Zone Observatory and the European Critical Zone Observatories within the SoilTrEC project. In the future implementation of WVO services will benefit from the development of a cloud cyber infrastructure as the prototype evolves to data and model intensive computation for continental scale water resource predictions.

Implications of Water Use and Hydroclimatic Anomalies on the Freshwater Sustainability across the US Sunbelt

NASA Astrophysics Data System (ADS)

Arumugam, S.; Sabo, J. L.; Ruhí, A.; Sinha, T.; Kominoski, J. S.; Hagler, M.; Kunkel, K.; Berglund, E.; Larson, K.; Mahinthakumar, K.

2014-12-01

A synthesis on freshwater sustainability is investigated across the US Sunbelt. Spatio-temporal variability of potential drivers - hydroclimate and water use - influencing the freshwater sustainability are examined both individually as well as collectively by considering the eco-region and 4-digit Hydrologic Unit Code (HUC-4)as the spatial reference for the analysis. A detailed analysis on national water use also indicates a north-south gradient with Frostbelt being more efficient in water use as opposed to the Sunbelt. This basically stems from the understanding of regional cross-differences in public supply consumption per capita which is significantly low in high-income urban counties. National analyses on agricultural water use efficiency (i.e., per-acreage application) also shows sprinkler irrigation and micro-irrigation being the primary drivers of differences in agricultural consumption. Given the well-known hydroclimatic west (arid)-east (humid) gradient across the Sunbelt, the study also evaluates the role of flow anomalies - represented by the changes in magnitude, frequency and timing of extremes (high flows and low flows) and by the changes in seasonality - in influencing native fish diversity patterns, as a proxy for freshwater biodiversity, in virgin basins and in basins influenced by significant storage and pumping. Cross-regional differences in water consumption during and after droughts are also presented in the context of adaptations and policy relevance.

EnviroAtlas National Layers Master Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). This web service includes layers depicting EnviroAtlas national metrics mapped at the 12-digit HUC within the conterminous United States. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Synthesis and characterization of a stable humic-urease complex: application to barley seed encapsulation for improving N uptake.

PubMed

Mvila, Beaufray G; Pilar-Izquierdo, María C; Busto, María D; Perez-Mateos, Manuel; Ortega, Natividad

2016-07-01

Most N fertilizers added to soil are not efficiently used by plants and are lost to the atmosphere or leached from the soil, causing environmental pollution and increasing cost. Barley seed encapsulation in calcium alginate gels containing free or immobilized urease to enhance plant utilization of soil N was investigated. Urease was immobilized with soil humic acids (HA). A central composite face-centered design was applied to optimize the immobilization process, reaching an immobilization yield of 127%. Soil stability of urease was enhanced after the immobilization. Seed encapsulation with free urease (FU) and humic-urease complex (HUC) resulted in a urease activity retention in the coating layer of 46% and 24%, and in germination rates of 87% and 92%, respectively. Under pot culture conditions, the pots planted with seeds encapsulated with FU and HUC showed higher ammonium N (NH4 (+) -N) (26% and 64%, respectively) than the control soil at 28 days after planting (DAP). Moreover, the seed encapsulation with FU and HUC increased the N uptake 83% and 97%, respectively, at 35 DAP. Seed encapsulation with urease could substantially contribute to enhancing plant N nutrition in the early stages of seedling establishment. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice.

PubMed

Sanna, Maria Domenica; Quattrone, Alessandro; Galeotti, Nicoletta

2018-06-01

Currently available antidepressant drugs often fail to achieve full remission and patients might evolve to treatment resistance, showing the need to achieve a better therapy of depressive disorders. Increasing evidence supports that post-transcriptional regulation of gene expression is important in neuronal development and survival and a relevant role is played by RNA binding proteins (RBP). To explore new therapeutic strategies, we investigated the role of the neuron-specific ELAV-like RBP (HuB, HuC, HuD) in a mouse model of depression. In this study, a 4-week unpredictable chronic mild stress (UCMS) protocol was applied to mice to induce a depressive-like phenotype. In the last 2 weeks of the UCMS regimen, silencing of HuB, HuC or HuD was performed by using specific antisense oligonucleotides (aODN). Treatment of UCMS-exposed mice with anti-HuB and anti-HuC aODN improved both anhedonia and behavioural despair, used as measures of depressive-like behaviour, without modifying the response of stressed mice to an anxiety-inducing environment. On the contrary, HuD silencing promoted an anxiolytic-like behaviour in UCMS-exposed mice without improving depressive-like behaviours. The antidepressant-like phenotype of anti-HuB and anti-HuC mice was not shown concurrently with the promotion of adult hippocampal neurogenesis in the dentate gyrus, and no increase in the BDNF and CREB content was detected. Conversely, in the CA3 hippocampal region, projection area of newly born neurons, HuB and HuC silencing increased the number of BrdU/NeuN positive cells. These results give the first indication of a role of nELAV in the modulation of emotional states in a mouse model of depression. Copyright © 2018 Elsevier Ltd. All rights reserved.

EnviroAtlas - Percent Stream Buffer Zone As Natural Land Cover for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset shows the percentage of land area within a 30 meter buffer zone along the National Hydrography Dataset (NHD) high resolution stream network, and along water bodies such as lakes and ponds that are connected via flow to the streams, that is classified as forest land cover, modified forest land cover, and natural land cover using the 2006 National Land Cover Dataset (NLCD) for each Watershed Boundary Dataset (WBD) 12-digit hydrological unit (HUC) in the conterminous United States. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

A biohybrid hydrogel for the urate-responsive release of urate oxidase.

PubMed

Geraths, Christian; Daoud-El Baba, Marie; Charpin-El Hamri, Ghislaine; Weber, Wilfried

2013-10-10

Functional biomaterials that detect and correct pathological parameters hold high promises for biomedical application. In this study we describe a biohybrid hydrogel that detects elevated concentrations of uric acid and responds by dissolution and the release of uric acid-degrading urate oxidase. This material was synthesized by incorporating PEG-stabilized urate oxidase into a polyacrylamide hydrogel that was crosslinked by the uric acid-sensitive interaction between the uric acid transcription factor HucR and its operator hucO. We characterize the uric acid responsiveness of the material and demonstrate that it can effectively be applied to counteract flares of uric acid in a mouse model. This approach might be a first step towards a biomedical device autonomously managing uric acid burst associated to gouty arthritis and the tumor lysis syndrome. © 2013.

Cytogenetic damage, oncogenic transformation and p53 induction in human epithelial cells in response to irradiation

NASA Astrophysics Data System (ADS)

Armitage, Mark

Ionizing radiation can have several different effects on cells, some are almost instantaneous such as the generation of DNA damage, other cellular responses take a matter of minutes or hours - DNA repair protein induction/activation, and others may take months or even years to be manifested - carcinogenesis. Human epithelial cell lines derived from both normal, non-neoplastic tissues and from a malignant source were cultured in order to examine several effects of ionizing radiation on such cell types. Cells not from a malignant source were previously immortalized by viral infection or by transfection with viral sequences. Simian virus 40 immortalised uroepithelial cells (SV-HUC) were found to be approximately a factor of two fold more radioresistant than cells of malignant origin (T24) in terms of unrepaired clastogenic damage i.e. assessment of micronuclei levels following irradiation. SV-HUC lines unlike T24 cells are non-tumourigenic when inoculated into nude athymic mice. SV-HUC lines proved very resistant to full oncogenic transformation using radiation and chemical carcinogens. However, morphological alterations and decreased anchorage dependant growth was observed in post carcinogen treated cells after appropriate cell culture conditions were utilized. The progression from this phenotype to a fully tumourigenic one was not recorded in this study. The ability of ionizing radiation to induce increased levels of the nuclear phosphoprotein p53 was also assessed using several different cell lines. SV- HUC and T24 cell lines failed to exhibit any increased p53 stabilization following irradiation. One cell line, a human papilloma virus transformed line (HPV) did show an approximate two fold increase of the wild type p53 protein after treatment with radiation. Only the cell line HPV showed any cell cycle delay, resulting in accumulation of cells in the G2/M compartment in post irradiation cell cycle analysis. The status of p53 was also assessed i.e. wild type or mutant conformation in all the above cells lines and two other control lines HOS (a human osteosarcoma cell line) and H Tori-3 (SV40 immortalised thyroid epithelial cells).

Local and Cumulative Impervious Cover of Massachusetts Stream Basins

USGS Publications Warehouse

Brandt, Sara L.; Steeves, Peter A.

2009-01-01

Impervious surfaces such as paved roads, parking lots, and building roofs can affect the natural streamflow patterns and ecosystems of nearby streams. This dataset summarizes the percentage of impervious area for watersheds across Massachusetts by using a newly available statewide 1-m binary raster dataset of impervious surface for 2005. In order to accurately capture the wide spatial variability of impervious surface, it was necessary to delineate a new set of finely discretized basin boundaries for Massachusetts. This new set of basins was delineated at a scale finer than that of the existing 12-digit Hydrologic Unit Code basins (HUC-12s) of the national Watershed Boundary Dataset. The dataset consists of three GIS shapefiles. The Massachusetts nested subbasins and the hydrologic units data layers consist of topographically delineated boundaries and their associated percentage of impervious cover for all of Massachusetts except Cape Cod, the Islands, and the Plymouth-Carver region. The Massachusetts groundwater-contributing areas data layer consists of groundwater contributing-area boundaries for streams and coastal areas of Cape Cod and the Plymouth-Carver region. These boundaries were delineated by using groundwater-flow models previously published by the U.S. Geological Survey. Subbasin and hydrologic unit boundaries were delineated statewide with the exception of Cape Cod and the Plymouth-Carver Region. For the purpose of this study, a subbasin is defined as the entire drainage area upstream of an outlet point. Subbasins draining to multiple outlet points on the same stream are nested. That is, a large downstream subbasin polygon comprises all of the smaller upstream subbasin polygons. A hydrologic unit is the intervening drainage area between a given outlet point and the outlet point of the next upstream unit (Fig. 1). Hydrologic units divide subbasins into discrete, nonoverlapping areas. Each hydrologic unit corresponds to a subbasin delineated from the same outlet point; the hydrologic unit and the subbasin share the same unique identifier attribute. Because the same set of outlet points was used for the delineation of subbasins and hydrologic units, the linework for both data layers is identical; however, polygon attributes differ because for a given outlet point, the subbasin polygon area is the sum of all the upstream hydrologic units. Impervious surface summarized for a subbasin represents the percentage of impervious surface area of the entire upstream watershed, whereas the impervious surface for a hydrologic unit represents the percentage of impervious surface area for the intervening drainage area between two outlet points.

Microelectrical Impedance Spectroscopy for the Differentiation between Normal and Cancerous Human Urothelial Cell Lines: Real-Time Electrical Impedance Measurement at an Optimal Frequency

PubMed Central

Park, Yangkyu; Kim, Hyeon Woo; Yun, Joho; Seo, Seungwan; Park, Chang-Ju; Lee, Jeong Zoo; Lee, Jong-Hyun

2016-01-01

Purpose. To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). Materials and Methods. Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channels of the devices. The first device (μEIS-OF) was designed to determine the optimal frequency at which the impedance of two cell lines is most distinguishable. The μEIS-OF trapped the flowing cells and measured their impedance at a frequency ranging from 5 kHz to 1 MHz. The second device (μEIS-RT) was designed for real-time impedance measurement of the cells at the optimal frequency. The impedance was measured instantaneously as the cells passed the sensing electrodes of μEIS-RT. Results. The optimal frequency, which maximized the average difference of the amplitude and phase angle between the two cell lines (p < 0.001), was determined to be 119 kHz. The real-time impedance of the cell lines was measured at 119 kHz; the two cell lines differed significantly in terms of amplitude and phase angle (p < 0.001). Conclusion. The μEIS-RT can discriminate SV-HUC-1 and TCCSUP cells by measuring the impedance at the optimal frequency determined by the μEIS-OF. PMID:26998490

EnviroAtlas - 303(d) Impairments by 12-digit HUC for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset depicts the total length of stream or river flowlines that have impairments submitted to the EPA by states under section 303(d) of the Clean Water Act. It also contains the total lengths of streams, rivers, and canals, total waterbody area, and stream density (stream length per area) from the US Geological Survey's high-resolution National Hydrography Dataset (NHD).This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

New distributional records of the stygobitic crayfish Cambarus cryptodytes (Decapoda: Cambaridae) in the Floridan Aquifer System of southwestern Georgia

USGS Publications Warehouse

Fenolio, Dante B.; Niemiller, Matthew L.; Gluesenkamp, Andrew G.; Mckee, Anna; Taylor, Steven J.

2017-01-01

Cambarus cryptodytes (Dougherty Plain Cave Crayfish) is an obligate inhabitant of groundwater habitats (i.e., a stygobiont) with troglomorphic adaptations in the Floridan aquifer system of southwestern Georgia and adjacent Florida panhandle, particularly in the Dougherty Plain and Marianna Lowlands. Documented occurrences of Dougherty Plain Cave Crayfish are spatially distributed as 2 primary clusters separated by a region where few caves and springs have been documented; however, the paucity of humanly accessible karst features in this intermediate region has inhibited investigation of the species' distribution. To work around this constraint, we employed bottle traps to sample for Dougherty Plain Cave Crayfish and other groundwater fauna in 18 groundwater-monitoring wells that access the Floridan aquifer system in 10 counties in southwestern Georgia. We captured 32 Dougherty Plain Cave Crayfish in 9 wells in 8 counties between September 2014 and August 2015. We detected crayfish at depths ranging from 17.9 m to 40.6 m, and established new county records for Early, Miller, Mitchell, and Seminole counties in Georgia, increasing the number of occurrences in Georgia from 8 to 17 sites. In addition, a new US Geological Survey (USGS) Hydrologic Unit Code 8 (HUC8) watershed record was established for the Spring Creek watershed. These new records fill in the distribution gap between the 2 previously known clusters in Georgia and Jackson County, FL. Furthermore, this study demonstrates that deployment of bottle traps in groundwater-monitoring wells can be an effective approach to presence—absence surveys of stygobionts, especially in areas where surface access to groundwater is limited.

Identification of N-(deoxyguanosin-8-yl)-4-azobiphenyl by (32)P-postlabeling analyses of DNA in human uroepithelial cells exposed to proximate metabolites of the environmental carcinogen 4-aminobiphenyl.

PubMed

Hatcher, James F; Swaminathan, Santhanam

2002-01-01

DNA adducts formed in human uroepithelial cells (HUC) following exposure to N-hydroxy-4-aminobiphenyl (N-OH-ABP), the proximate metabolite of the human bladder carcinogen 4-aminobiphenyl (ABP), were analyzed by the (32)P-postlabeling method. Two adducts detected by (32)P-postlabeling were previously identified as the 3',5'-bisphospho derivatives of N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-ABP) and N-(deoxyadenosin-8-yl)-4-aminobiphenyl (dA-C8-ABP) (Frederickson S et al. [1992] Carcinogenesis 13: 955-961; Hatcher and Swaminathan [1995b] Carcinogenesis 16: 295-301). In contrast to the dG-C8-ABP adduct, which was 3'-dephosphorylated by nuclease P1, dA-C8-ABP was resistant to nuclease P1, thus providing an enrichment step before postlabeling. Autoradiography of the two-dimensional thin-layer chromatogram of the postlabeled products obtained following nuclease P1 digestion revealed several minor adducts, one of which has been identified in the present study. Postlabeling analyses following nuclease P1 digestion of the products obtained from the reaction of N-acetoxy-4-aminobiphenyl with deoxyguanosine-3'-monophosphate (dGp) demonstrated the presence of this minor adduct. The 3'-monophosphate derivative of the adduct was subsequently chromatographically purified and subjected to spectroscopic analyses. Based on proton NMR and mass spectroscopic analyses of the synthetic product, the chemical structure of the adduct has been identified as N-(deoxyguanosin-N(2)-yl)-4-azobiphenyl (dG-N==N-ABP). (32)P-Postlabeling analysis of the nuclease P1-enriched DNA hydrolysate of HUCs treated with N-OH-ABP or N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) showed the presence of the dG-N==N-ABP adduct. It was also detected in calf thymus DNA incubated with HUC cytosol and N-OH-ABP in the presence of acetyl-CoA, or incubated with HUC microsomes and N-OH-AABP. These results demonstrate that in the target cells for ABP carcinogenesis in vivo, N-OH-ABP and N-OH-AABP are bioactivated by acyltransferases to reactive arylnitrenium ions that covalently interact at the N2 position of deoxyguanosine in DNA. Copyright 2002 Wiley-Liss, Inc.

Estimation of shallow ground-water recharge in the Great Lakes basin

USGS Publications Warehouse

Neff, B.P.; Piggott, A.R.; Sheets, R.A.

2006-01-01

This report presents the results of the first known integrated study of long-term average ground-water recharge to shallow aquifers (generally less than 100 feet deep) in the United States and Canada for the Great Lakes, upper St. Lawrence, and Ottawa River Basins. The approach used was consistent throughout the study area and allows direct comparison of recharge rates in disparate parts of the study area. Estimates of recharge are based on base-flow estimates for streams throughout the Great Lakes Basin and the assumption that base flow in a given stream is equal to the amount of shallow ground-water recharge to the surrounding watershed, minus losses to evapotranspiration. Base-flow estimates were developed throughout the study area using a single model based on an empirical relation between measured base-flow characteristics at streamflow-gaging stations and the surficial-geologic materials, which consist of bedrock, coarse-textured deposits, fine-textured deposits, till, and organic matter, in the surrounding surface-water watershed. Model calibration was performed using base-flow index (BFI) estimates for 959 stations in the U.S. and Canada using a combined 28,784 years of daily streamflow record determined using the hydrograph-separation software program PART. Results are presented for watersheds represented by 8-digit hydrologic unit code (HUC, U.S.) and tertiary (Canada) watersheds. Recharge values were lowest (1.6-4.0 inches/year) in the eastern Lower Peninsula of Michigan; southwest of Green Bay, Wisconsin; in northwestern Ohio; and immediately south of the St. Lawrence River northeast of Lake Ontario. Recharge values were highest (12-16.8 inches/year) in snow shadow areas east and southeast of each Great Lake. Further studies of deep aquifer recharge and the temporal variability of recharge would be needed to gain a more complete understanding of ground-water recharge in the Great Lakes Basin.

Flow characteristics at U.S. Geological Survey streamgages in the conterminous United States

USGS Publications Warehouse

Wolock, David

2003-01-01

This dataset represents point locations and flow characteristics for current (as of November 20, 2001) and historical U.S. Geological Survey (USGS) streamgages in the conterminous United States. The flow characteristics were computed from the daily streamflow data recorded at each streamgage for the period of record. The attributes associated with each streamgage include: Station number Station name Station latitude (decimal degrees in North American Datum of 1983, NAD 83) Station longitude (decimal degrees in NAD 83) First date (year, month, day) of streamflow data Last date (year, month, day) of streamflow data Number of days of streamflow data Minimum and maximum daily flow for the period of record (cubic feet per second) Percentiles (1, 5, 10, 20, 25, 50, 75, 80, 90, 95, 99) of daily flow for the period of record (cubic feet per second) Average and standard deviation of daily flow for the period of record (cubic feet per second) Mean annual base-flow index (BFI: see supplemental information) computed for the period of record (fraction, ranging from 0 to 1) Year-to-year standard deviation of the annual base-flow index computed for the period of record (fraction) Number of years of data used to compute the base-flow index (years) Reported drainage area (square miles) Reported contributing drainage area (square miles) National Water Information System (NWIS)-Web page URL for streamgage Hydrologic Unit Code (HUC, 8 digit) Hydrologic landscape region (HLR) River Reach File 1 (RF1) segment identification number (E2RF1##) Station numbers, names, locations, and drainage areas were acquired through the National Water Information System (NWIS)-Web (http://water.usgs.gov/nwis) on November 20, 2001. The streamflow data used to compute flow characteristics were copied from the Water server (water.usgs.gov:/www/htdocs/nwisweb/data1/discharge/) on November 2, 2001. The missing value indicator for all attributes is -99. Some streamflow characteristics are missing for: (1) streamgages measuring flow subject to tidal effects, which cause flow to reverse directions, (2) streamgages with site information but no streamflow data at the time the data were retrieved, and (3) streamgages with record length too short to compute the base-flow index.

Differentiation of human adipose-derived stem cells co-cultured with urothelium cell line toward a urothelium-like phenotype in a nude murine model.

PubMed

Zhang, Ming; Peng, Yubing; Zhou, Zhe; Zhou, Juan; Wang, Zhong; Lu, Mujun

2013-02-01

To investigated the urothelium differentiation potential of adipose-derived stem cells (ASCs) that were coimplanted with the immortalized human bladder urothelium cell line (SV-HUC-1) into the subcutaneous tissue of athymic mice. The ASCs were isolated from the human adipose tissue of patients undergoing liposuction procedures and were expanded in vitro. After labeling with CM-DiI, the ASCs were mixed with SV-HUC-1 and implanted into the subcutaneous tissue of athymic mice for 2 and 4 weeks. The urothelium-specific markers uroplakin-Ia and uroplakin-II were detected by immunofluorescence. The transformation rate of ASCs into the urothelium phenotype was evaluated at each measurement point. We found that 25.87% ± 1.38% of ASCs expressed the urothelium-specific marker uroplakin-Ia and 23.60% ± 2.57% of ASCs expressed uroplakin-II 2 weeks after coimplantation with SV-HUC-1 in vivo. After 4 weeks, 70.07% ± 3.84% of ASCs expressed uroplakin-Ia and 65.56% ± 2.94% expressed uroplakin-II. However, no obvious organizational multilayered urothelium structure, such as that of the native bladder mucosa, was found in the subcutaneous tissues of the athymic mice. The results of our study have demonstrated that ASCs could be differentiated toward the urothelium-like phenotype when they were coimplanted in direct contact with cells of a mature urothelium cell line, and the proportion of differentiated cells increased from 2 to 4 weeks. The differentiation potential of ASCs toward the urothelial cell type suggests that ASCs might have potential to be used in urinary tract repair with a tissue engineering approach in the future. Copyright © 2013 Elsevier Inc. All rights reserved.

Evaluation of Lactic Acid Bacteria Isolated from Fermented Plant Products for Antagonistic Activity Against Urinary Tract Pathogen Staphylococcus saprophyticus.

PubMed

Tsai, Cheng-Chih; Lai, Tzu-Min; Lin, Pei-Pei; Hsieh, You-Miin

2018-06-01

Urinary tract infections (UTIs) are the most common infectious diseases in infants and the elderly; they are also the most common among nosocomial infections. The treatment of UTIs usually involves a short-term course of antibiotics. The purpose of this study was to identify the strains of lactic acid bacteria (LAB) that can inhibit the urinary tract pathogen Staphylococcus saprophyticus, as alternatives to antibiotics. In this study, we collected 370 LAB strains from fermented plant products and reference strains from the Bioresources Collection and Research Center (BCRC). Using spent culture supernatants (SCS), we then screened these LAB strains with for antimicrobial effects on urinary tract pathogens by the well-diffusion assay. Seven LAB strains-PM2, PM68, PM78, PM201, PM206, PM229, and RY2-exhibited inhibitory activity and were evaluated for anti-growth activity against urinary tract pathogens by the co-culture inhibition assay. Anti-adhesion and anti-invasion activities against urinary tract pathogens were evaluated using the SV-HUC-1 urothelial cell cultures. The results revealed that the survival rate of S. saprophyticus ranged from 0.9-2.96%, with the pH continuously decreasing after co-culture with LAB strains for 4 h. In the competitive adhesion assay, the exclusion and competition groups performed better than the displacement group. In the SV-HUC-1 cell invasion assay, PM201, PM206, PM229, and RY2 were found to inhibit the invasion of SV-HUC-1 cells by S. saprophyticus BCRC 10786. To conclude, RY2, PM229, and PM68 strains exhibited inhibitory activity against the urinary tract pathogen S. saprophyticus.

Sources and Loading of Nitrogen to U.S. Estuaries

EPA Science Inventory

Previous assessments of land-based nitrogen loading and sources to U.S. estuaries have been limited to estimates for larger systems with watersheds at the scale of 8-digit HUCs and larger, in part due to the coarse resolution of available data, including estuarine watershed bound...

Acquisition Of Rainfall Dataset And The Application For The Automatic Harvester In The Chesapeake Bay Region

NASA Astrophysics Data System (ADS)

Choi, Y.; Piasecki, M.

2008-12-01

The objective of this study is the preparation and indexing of rainfall data products for ingestion into the Chesapeake Bay Environmental Observatory (CBEO) node of the CUAHSI/WATERs network. Rainfall products (which are obtained and then processed based on the WSR-88D NEXRAD network) are obtained from the NOAA/NWS Advanced Hydrologic Prediction Service that combines the Multi-sensor Precipitation Estimate (MPE) data generated by the Regional River Forecast Centers and Hydro-NEXRAD rainfall data generated as a service by the University of Iowa. The former is collected on 4*4 km grid (HRAP) with a daily average temporal resolution and the latter on a 1minute*1minute degree grid with hourly values. We have generated a cut-out for the Chesapeake Bay Basin that contains about 9,300 nodes (sites) for the MPE data and about 300,000 nodes (sites) for the Hydro-NEXRAD product. Automated harvesting services have been implemented for both data products. The MPE data is harvested from its download site using ArcGIS which in turn is used to extract the data for the Chesapeake Bay watershed before a scripting program is used to scatter the data into the ODM. The Hydro-NEXRAD is downloaded from a web-based system at the University of Iowa which permits downloads for large scale watersheds organized by Hydraulic Unit Codes (HUC). The resulting ASCII is then automatically parsed and the information stored alongside the MPE data. The two data products stored side-by-side then allows a comparison between them addressing the accuracy and agreement between the methods used to arrive at rainfall data as both use the raw reflectivity data from the WSD-88D system.

Agricultural conservation planning framework: 1. Developing multi-practice watershed planning scenarios and assessing nutrient reduction potential

USDA-ARS?s Scientific Manuscript database

We show that spatial data on soils, land use, and high-resolution topography, combined with knowledge of conservation practice effectiveness, can be leveraged to identify and assess alternatives to reduce nutrient discharge from small (HUC12) agricultural watersheds. Databases comprising soil attrib...

Evaluating the Effect of Green Infrastructure Stormwater Best Management Practices on New England Stream Habitat

EPA Science Inventory

The U.S. EPA is evaluating the effectiveness of green infrastructure (GI) stormwater best management practices (BMPs) on stream habitat at the small watershed (< HUC12) scale in New England. Predictive models for thermal regime and substrate characteristics (substrate size, % em...

Agricultural conservation planning framework: 2. Classification of riparian buffer design-types with application to assess and map stream corridors

USDA-ARS?s Scientific Manuscript database

A watershed’s riparian corridor presents opportunities to stabilize streambanks, intercept runoff, and influence shallow groundwater with riparian buffers. This paper presents a system to classify these riparian opportunities and apply it towards riparian management planning in HUC12 watersheds. Hig...

Evaluating Effectiveness of Green Infrastructure Application of Stormwater Best Management Practices in Protecting Stream Habitat and Biotic Condition in New England

EPA Science Inventory

The US EPA is developing assessment tools to evaluate the effectiveness of green infrastructure (GI) applied in stormwater best management practices (BMPs) at the small watershed (HUC12 or finer) scale. Based on analysis of historical monitoring data using boosted regression tre...

Exogenous C3 protein enhances the adaptive immune response to polymicrobial sepsis through down-regulation of regulatory T cells.

PubMed

Yuan, Yujie; Ren, Jianan; Cao, Shougen; Zhang, Weiwei; Li, Jieshou

2012-01-01

The role of complement system in bridging innate and adaptive immunity has been confirmed in various invasive pathogens. It is still obscure how complement proteins promote T cell-mediated immune response during sepsis. The aim of this study is to investigate the role of exogenous C3 protein in the T-cell responses to sepsis. Sepsis was induced by colon ascendens stent peritonitis (CASP) in wild-type C57BL/6 mice, sham-operated mice for control. Human purified C3 protein (HuC3, 1 mg) was intraperitoneally injected at 6 h post-surgery, with 200 μl phosphate-buffered saline as control. The levels of C3 and cytokines, the expression of FOXP3 and NF-κB, and the percentages of CD4(+) T-cell subsets were compared among the groups at given time points. The polymicrobial sepsis produced considerable release of TNF-α and IL-10, and caused complement C3 exhaustion. Exogenous C3 administration markedly improved the 48 h survival rate, as compared with nontreatment (40% vs. 5%, P<0.01). The expression of FOXP3 protein was increased during sepsis, but can be suppressed by HuC3 administration. A single injection of HuC3 postponed the decline of differentiated Th1 cells, and depressed the activation of Th2/Th17 cells. Besides, the Th1-Th2 shift in late stage of sepsis can be controlled under C3 supplementation. The suppression of NF-κB pathway might be related to the appearance of immunocompromise. The study confirmed the important role of exogenous C3 in up-regulation of adaptive immune response to sepsis. The complement pathway would be a pivotal target for severe sepsis management. Copyright © 2011 Elsevier B.V. All rights reserved.

Estimated Withdrawals and Other Elements of Water Use in the Great Lakes Basin of the United States in 2005

USGS Publications Warehouse

Mills, Patrick C.; Sharpe, Jennifer B.

2010-01-01

Estimates of water withdrawals in the United States part of the Great Lakes Basin and 107 of its watersheds designated by the 8-digit hydrologic unit code (HUCs) indicate that about 30.3 billion gallons per day (Bgal/d) were withdrawn for practically all categories of use in 2005. Virtually all water withdrawn was freshwater. Surface-water withdrawals totaled 28.8 Bgal/d, or 95 percent of total withdrawals; about 24 Bgal/d was withdrawn from the Great Lakes or their connecting channels. Total withdrawals, and total surface-water withdrawals, decreased 7 percent from 1995 to 2005, generally following the withdrawal trends of industrial use and that of the largest use-thermoelectric power. Groundwater withdrawals increased 3 percent from 1995 to 2005 and 33 percent during 1985-2005. The substantial increase since 1985 results primarily from increases in irrigation and self-supplied domestic withdrawals. In 2005, withdrawals for public supply, domestic, and irrigation use accounted for 81 percent of groundwater withdrawals. About 21.9 Bgal/d, or 72 percent of total withdrawals for 2005, was used for thermoelectric power. Virtually all of this water was derived from surface water and used for once-through cooling at powerplants. As such, the reuse potential of this water in the basin is high, with the majority of the withdrawn water returned to its surface-water source. Public-supply withdrawals were 3.81 Bgal/d (13 percent), with withdrawals declining by about 13 percent from 1995 to 2005. In 2005, about 77 percent of the population in the Great Lakes Basin obtained drinking water from public suppliers, compared to about 78 percent in 1995 and 83 percent in 1985. Surface water consistently provided about 88 percent of the total withdrawals for public supply since 1985. Self-supplied industrial withdrawals in 2005 totaled 2.93 Bgal/d (10 percent), possibly as much as 30 percent less than in 1995. Surface water was the source for 95 percent of industrial withdrawals. Combined withdrawals for mining, irrigation, domestic, aquaculture, and livestock use (in order of decreasing rate) were 1.63 Bgal/d, or only 5 percent of total withdrawals; the withdrawals were distributed almost equally between surface-water and groundwater sources. Withdrawals for each of these uses, except livestock, increased almost continuously during 1985-2005. Withdrawals for mining increased 103 percent and for irrigation 94 percent during 1985-2005; livestock withdrawals decreased 25 percent from their peak in 1990. The number of irrigated acres increased 56 percent since 1985, totaling 750,000 acres in 2005. No use of reclaimed wastewater for industrial or irrigation applications was reported; however, sources of information regarding its use were sparse. Within the basin, the Lake Michigan watershed accounted for 15.0 Bgal/d, or 49 percent, of total water withdrawals for 2005; an estimated 12.3 Bgal/d was withdrawn directly from Lake Michigan. The State of Michigan accounted for 38 percent of total water withdrawals, representing the largest surface-water withdrawals (primarily for thermoelectric power use) and groundwater withdrawals (primarily for public supply and self-supplied domestic use). A disproportionately large percentage of surface-water withdrawals (6 percent, 1.80 Bgal/d) were in Illinois, given this state represents less than 1 percent of the land area of the basin. Ninety percent of the Illinois population served by the water withdrawn from Lake Michigan for public supply resides outside the basin. Within land-based HUCs, the Lower Maumee (04100009) of Ohio accounted for the largest total withdrawal and total surface-water withdrawal (about 0.75 Bgal/d). The St. Joseph (04050001) of Michigan and Indiana accounted for the largest total groundwater withdrawal (0.25 Bgal/d).

National Unity and Ethnic Identity in a Vietnamese University

ERIC Educational Resources Information Center

Tran, Linh T.; Walter, Pierre G.

2010-01-01

In this article, the authors discuss the ways in which Vietnam's educational policies for ethnic minorities are enacted in the bachelor of arts (BA) program in ethnic minority cultures (EMC) at the Hanoi University of Culture (HUC). Hanoi University of Culture is one of only two universities in Vietnam that offer this program. Although the BA is…

Sensitivity of Hydrologic Extremes to Spatial Resolution of Meteorological Forcings: A Case Study of the Conterminous United States

NASA Astrophysics Data System (ADS)

Kao, S. C.; Naz, B. S.; Gangrade, S.; Ashfaq, M.; Rastogi, D.

2016-12-01

The magnitude and frequency of hydroclimate extremes are projected to increase in the conterminous United States (CONUS) with significant implications for future water resource planning and flood risk management. Nevertheless, apart from the change of natural environment, the choice of model spatial resolution could also artificially influence the features of simulated extremes. To better understand how the spatial resolution of meteorological forcings may affect hydroclimate projections, we test the runoff sensitivity using the Variable Infiltration Capacity (VIC) model that was calibrated for each CONUS 8-digit hydrologic unit (HUC8) at 1/24° ( 4km) grid resolution. The 1980-2012 gridded Daymet and PRISM meteorological observations are used to conduct the 1/24° resolution control simulation. Comparative simulations are achieved by smoothing the 1/24° forcing into 1/12° and 1/8° resolutions which are then used to drive the VIC model for the CONUS. In addition, we also test how the simulated high and low runoff conditions would react to change in precipitation (±10%) and temperature (+1°C). The results are further analyzed for various types of hydroclimate extremes across different watersheds in the CONUS. This work helps us understand the sensitivity of simulated runoff to different spatial resolutions of climate forcings and also its sensitivity to different watershed sizes and characteristics of extreme events in the future climate conditions.

Leukemia inhibitory factor (LIF) enhances MAP2 + and HUC/D + neurons and influences neurite extension during differentiation of neural progenitors derived from human embryonic stem cells.

EPA Science Inventory

Leukemia Inhibitory Factor (L1F), a member of the Interleukin 6 cytokine family, has a role in differentiation of Human Neural Progenitor (hNP) cells in vitro. hNP cells, derived from Human Embryonic Stem (hES) cells, have an unlimited capacity for self-renewal in monolayer cultu...

Increasingly, Data Availability Limits Model Predictive Capacity: the Western Lake Erie Basin, a Case Study

NASA Astrophysics Data System (ADS)

Behrman, K. D.; Johnson, M. V. V.; Atwood, J. D.; Norfleet, M. L.

2016-12-01

Recent algal blooms in Western Lake Erie Basin (WLEB) have renewed scientific community's interest in developing process based models to better understand and predict the drivers of eutrophic conditions in the lake. At the same time, in order to prevent future blooms, farmers, local communities and policy makers are interested in developing spatially explicit nutrient and sediment management plans at various scales, from field to watershed. These interests have fueled several modeling exercises intended to locate "hotspots" in the basin where targeted adoption of additional agricultural conservation practices could provide the most benefit to water quality. The models have also been used to simulate various scenarios representing potential agricultural solutions. The Soil and Water Assessment Tool (SWAT) and its sister model, the Agricultural Policy Environmental eXtender (APEX), have been used to simulate hydrology of interacting land uses in thousands of scientific studies around the world. High performance computing allows SWAT and APEX users to continue to improve and refine the model specificity to make predictions at small-spatial scales. Consequently, data inputs and calibration/validation data are now becoming the limiting factor to model performance. Water quality data for the tributaries and rivers that flow through WLEB is spatially and temporally limited. Land management data, including conservation practice and nutrient management data, are not publicly available at fine spatial and temporal scales. Here we show the data uncertainties associated with modeling WLEB croplands at a relatively large spatial scale (HUC-4) using site management data from over 1,000 farms collected by the Conservation Effects Assessment Project (CEAP). The error associated with downscaling this data to the HUC-8 and HUC-12 scale is shown. Simulations of spatially explicit dynamics can be very informative, but care must be taken when policy decisions are made based on models with unstated, but implicit assumptions. As we interpret modeling results, we must communicate the spatial and temporal scale for which the model was developed and at which the data is valid. When there is little to no data to enable appropriate validation and calibration, the results must be interpreted with appropriate skepticism.

Capturing the externalities: National and watershed scale damages from release of reactive nitrogen beyond the farm, factory, tailpipe and table

NASA Astrophysics Data System (ADS)

Compton, J.; Sobota, D. J.; McCrackin, M. L.; Harrison, J.

2014-12-01

Human demand for food, fuel, and industrial products results in the release of 61% of the newly fixed anthropogenic N to the environment in the US each year. This 15.8 Tg N yr-1 input to air, land and water has important social, economic and environmental consequences, yet little research clearly links this N release to the full suite of effects. Here we connect the biogeochemical fluxes of N with existing data on N-associated damages in order to quantify the externalities of N release related to human health, ecosystems and climate regulation for the US at national and watershed scales. Release of N to the environment was estimated circa 2000 with models describing N inputs by source, nutrient uptake efficiency, leaching losses, and gaseous emissions at the scale of 8-digit US Geologic Survey Hydrologic Unit Codes (HUC8s). Potential damages or benefits of anthropogenic N leaked to the environment were calculated by scaling specific N fluxes with the costs associated with human health, agriculture, ecosystems, and the climate system. For the US, annual damage costs of anthropogenic N leaked to the environment in 2000 totaled 289 billion USD. Approximately 57% of the total damages were associated with fossil fuel combustion, driven by the human respiratory health impacts of NOx as a precursor of ozone and a component of particulates. Another 37% of the damage costs were associated with agricultural N. Damages associated with agriculture were 85.5 billion, largely through eutrophication and harmful effects on aquatic habitat. Through aggressive but tangible improvements in atmospheric emissions, agricultural N use and wastewater treatment, we could reduce N export to the coast by nearly 25% within 30 years. These improvements would reduce the externalities associated with the leakage of N beyond its intended uses in agriculture, transportation and energy with minimal impact to these sectors dependent on anthropogenic N fixation.

Evaluation of Drought Implications on Ecosystem Services: Freshwater Provisioning and Food Provisioning in the Upper Mississippi River Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Ping; Omani, Nina; Chaubey, Indrajeet

Drought is one of the most widespread extreme climate events with a potential to alter freshwater availability and related ecosystem services. Given the interconnectedness between freshwater availability and many ecosystem services, including food provisioning, it is important to evaluate the drought implications on freshwater provisioning and food provisioning services. Studies about drought implications on streamflow, nutrient loads, and crop yields have been increased and these variables are all process-based model outputs that could represent ecosystem functions that contribute to the ecosystem services. However, few studies evaluate drought effects on ecosystem services such as freshwater and food provisioning and quantify thesemore » services using an index-based ecosystem service approach. In this study, the drought implications on freshwater and food provisioning services were evaluated for 14 four-digit HUC (Hydrological Unit Codes) subbasins in the Upper Mississippi River Basin (UMRB), using three drought indices: standardized precipitation index (SPI), standardized soil water content index (SSWI), and standardized streamflow index (SSI). The results showed that the seasonal freshwater provisioning was highly affected by the precipitation deficits and/or surpluses in summer and autumn. A greater importance of hydrological drought than meteorological drought implications on freshwater provisioning was evident for the majority of the subbasins, as evidenced by higher correlations between freshwater provisioning and SSI12 than SPI12. Food provisioning was substantially affected by the precipitation and soil water deficits during summer and early autumn, with relatively less effect observed in winter. A greater importance of agricultural drought effects on food provisioning was evident for most of the subbasins during crop reproductive stages. Results from this study may provide insights to help make effective land management decisions in responding to extreme climate conditions in order to protect and restore freshwater provisioning and food provisioning services in the UMRB.« less

Evaluation of Drought Implications on Ecosystem Services: Freshwater Provisioning and Food Provisioning in the Upper Mississippi River Basin.

PubMed

Li, Ping; Omani, Nina; Chaubey, Indrajeet; Wei, Xiaomei

2017-05-08

Drought is one of the most widespread extreme climate events with a potential to alter freshwater availability and related ecosystem services. Given the interconnectedness between freshwater availability and many ecosystem services, including food provisioning, it is important to evaluate the drought implications on freshwater provisioning and food provisioning services. Studies about drought implications on streamflow, nutrient loads, and crop yields have been increased and these variables are all process-based model outputs that could represent ecosystem functions that contribute to the ecosystem services. However, few studies evaluate drought effects on ecosystem services such as freshwater and food provisioning and quantify these services using an index-based ecosystem service approach. In this study, the drought implications on freshwater and food provisioning services were evaluated for 14 four-digit HUC (Hydrological Unit Codes) subbasins in the Upper Mississippi River Basin (UMRB), using three drought indices: standardized precipitation index ( SPI ), standardized soil water content index ( SSWI ), and standardized streamflow index ( SSI ). The results showed that the seasonal freshwater provisioning was highly affected by the precipitation deficits and/or surpluses in summer and autumn. A greater importance of hydrological drought than meteorological drought implications on freshwater provisioning was evident for the majority of the subbasins, as evidenced by higher correlations between freshwater provisioning and SSI 12 than SPI 12. Food provisioning was substantially affected by the precipitation and soil water deficits during summer and early autumn, with relatively less effect observed in winter. A greater importance of agricultural drought effects on food provisioning was evident for most of the subbasins during crop reproductive stages. Results from this study may provide insights to help make effective land management decisions in responding to extreme climate conditions in order to protect and restore freshwater provisioning and food provisioning services in the UMRB.

Evaluation of Drought Implications on Ecosystem Services: Freshwater Provisioning and Food Provisioning in the Upper Mississippi River Basin

PubMed Central

Li, Ping; Omani, Nina; Chaubey, Indrajeet; Wei, Xiaomei

2017-01-01

Drought is one of the most widespread extreme climate events with a potential to alter freshwater availability and related ecosystem services. Given the interconnectedness between freshwater availability and many ecosystem services, including food provisioning, it is important to evaluate the drought implications on freshwater provisioning and food provisioning services. Studies about drought implications on streamflow, nutrient loads, and crop yields have been increased and these variables are all process-based model outputs that could represent ecosystem functions that contribute to the ecosystem services. However, few studies evaluate drought effects on ecosystem services such as freshwater and food provisioning and quantify these services using an index-based ecosystem service approach. In this study, the drought implications on freshwater and food provisioning services were evaluated for 14 four-digit HUC (Hydrological Unit Codes) subbasins in the Upper Mississippi River Basin (UMRB), using three drought indices: standardized precipitation index (SPI), standardized soil water content index (SSWI), and standardized streamflow index (SSI). The results showed that the seasonal freshwater provisioning was highly affected by the precipitation deficits and/or surpluses in summer and autumn. A greater importance of hydrological drought than meteorological drought implications on freshwater provisioning was evident for the majority of the subbasins, as evidenced by higher correlations between freshwater provisioning and SSI12 than SPI12. Food provisioning was substantially affected by the precipitation and soil water deficits during summer and early autumn, with relatively less effect observed in winter. A greater importance of agricultural drought effects on food provisioning was evident for most of the subbasins during crop reproductive stages. Results from this study may provide insights to help make effective land management decisions in responding to extreme climate conditions in order to protect and restore freshwater provisioning and food provisioning services in the UMRB. PMID:28481311

Predicting future US water yield and ecosystem productivity by linking an ecohydrological model to WRF dynamically downscaled climate projections

NASA Astrophysics Data System (ADS)

Sun, S.; Sun, G.; Cohen, E.; McNulty, S. G.; Caldwell, P.; Duan, K.; Zhang, Y.

2015-12-01

Quantifying the potential impacts of climate change on water yield and ecosystem productivity (i.e., carbon balances) is essential to developing sound watershed restoration plans, and climate change adaptation and mitigation strategies. This study links an ecohydrological model (Water Supply and Stress Index, WaSSI) with WRF (Weather Research and Forecasting Model) dynamically downscaled climate projections of the HadCM3 model under the IPCC SRES A2 emission scenario. We evaluated the future (2031-2060) changes in evapotranspiration (ET), water yield (Q) and gross primary productivity (GPP) from the baseline period of 1979-2007 across the 82 773 watersheds (12 digit Hydrologic Unit Code level) in the conterminous US (CONUS), and evaluated the future annual and monthly changes of hydrology and ecosystem productivity for the 18 Water Resource Regions (WRRs) or 2-digit HUCs. Across the CONUS, the future multi-year means show increases in annual precipitation (P) of 45 mm yr-1 (6 %), 1.8 °C increase in temperature (T), 37 mm yr-1 (7 %) increase in ET, 9 mm yr-1 (3 %) increase in Q, and 106 g C m-2 yr-1 (9 %) increase in GPP. Response to climate change was highly variable across the 82, 773 watersheds, but in general, the majority would see consistent increases in all variables evaluated. Over half of the 82 773 watersheds, mostly found in the northeast and the southern part of the southwest would have an increase in annual Q (>100 mm yr-1 or 20 %). This study provides an integrated method and example for comprehensive assessment of the potential impacts of climate change on watershed water balances and ecosystem productivity at high spatial and temporal resolutions. Results will be useful for policy-makers and land managers in formulating appropriate watershed-specific strategies for sustaining water and carbon sources in the face of climate change.

Evaluation of Drought Implications on Ecosystem Services: Freshwater Provisioning and Food Provisioning in the Upper Mississippi River Basin

DOE PAGES

Li, Ping; Omani, Nina; Chaubey, Indrajeet; ...

2017-05-08

Drought is one of the most widespread extreme climate events with a potential to alter freshwater availability and related ecosystem services. Given the interconnectedness between freshwater availability and many ecosystem services, including food provisioning, it is important to evaluate the drought implications on freshwater provisioning and food provisioning services. Studies about drought implications on streamflow, nutrient loads, and crop yields have been increased and these variables are all process-based model outputs that could represent ecosystem functions that contribute to the ecosystem services. However, few studies evaluate drought effects on ecosystem services such as freshwater and food provisioning and quantify thesemore » services using an index-based ecosystem service approach. In this study, the drought implications on freshwater and food provisioning services were evaluated for 14 four-digit HUC (Hydrological Unit Codes) subbasins in the Upper Mississippi River Basin (UMRB), using three drought indices: standardized precipitation index (SPI), standardized soil water content index (SSWI), and standardized streamflow index (SSI). The results showed that the seasonal freshwater provisioning was highly affected by the precipitation deficits and/or surpluses in summer and autumn. A greater importance of hydrological drought than meteorological drought implications on freshwater provisioning was evident for the majority of the subbasins, as evidenced by higher correlations between freshwater provisioning and SSI12 than SPI12. Food provisioning was substantially affected by the precipitation and soil water deficits during summer and early autumn, with relatively less effect observed in winter. A greater importance of agricultural drought effects on food provisioning was evident for most of the subbasins during crop reproductive stages. Results from this study may provide insights to help make effective land management decisions in responding to extreme climate conditions in order to protect and restore freshwater provisioning and food provisioning services in the UMRB.« less

Integrated Energy-Water Planning in the Western and Texas Interconnections (Invited)

NASA Astrophysics Data System (ADS)

Tidwell, V. C.

2013-12-01

While thermoelectric power generation accounts for less than one percent of total water consumption in the western U.S, steady growth in demand is projected for this sector. Complexities and heterogeneity in water supply, water demand, and institutional controls make water development a challenging proposition throughout the West. A consortium of National Laboratories, the University of Texas and the Electric Power Research Institute are working with the Western Governors' Association and Western States Water Council to assist the Western Electricity Coordinating Council and the Electric Reliability Council of Texas to integrate water related issues into long-term transmission planning. Specifically, water withdrawal and consumption have been estimated for each western power plant and their susceptibility to climate impacts assessed. To assist with transmission planning, water availability and cost data have been mapped at the 8-digit Hydrologic Unit Code level for the conterminous western U.S. (1208 watersheds). Five water sources were individually considered, including unappropriated surface water, unappropriated groundwater, appropriated water, municipal wastewater and brackish groundwater. Also mapped is projected growth in consumptive water demand to 2030. The relative costs (capital and O&M) to secure, convey, and treat the water as necessary have also been estimated for each source of water. These data configured into watershed level supply curves were subsequently used to constrain West-wide transmission planning. Results across a range of alternative energy futures indicate the impact of water availability and cost on the makeup and siting of future power generation. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Water budgets at a 8-digit HUC level constructed by aggregating available water (all five sources) and subtracting projected change in demand for 2010-2030.

"Like a Distant Cousin": Bi-Cultural Negotiation as Key Perspective in Understanding the Evolving Relationship of Future Reform Rabbis with Israel and the Jewish People

ERIC Educational Resources Information Center

Muszkat-Barkan, Michal; Grant, Lisa D.

2015-01-01

This research explores the impact of a year studying in Israel on Hebrew Union College-Jewish Institute of Religion (HUC-JIR) rabbinical students' emotional connection toward and knowledge about the State of Israel and the Jewish People. We want to better understand the students' beliefs, ideas, and behaviors that emerge from their experience…

Extraction and development of inset models in support of groundwater age calculations for glacial aquifers

USGS Publications Warehouse

Feinstein, Daniel T.; Kauffman, Leon J.; Haserodt, Megan J.; Clark, Brian R.; Juckem, Paul F.

2018-06-22

The U.S. Geological Survey developed a regional model of Lake Michigan Basin (LMB). This report describes the construction of five MODFLOW inset models extracted from the LMB regional model and their application using the particle-tracking code MODPATH to simulate the groundwater age distribution of discharge to wells pumping from glacial deposits. The five study areas of the inset model correspond to 8-digit hydrologic unit code (HUC8) basins. Two of the basins are tributary to Lake Michigan from the east, two are tributary to the lake from the west, and one is just west of the western boundary of the Lake Michigan topographic basin. The inset models inherited many of the inputs to the parent LMB model, including the hydrostratigraphy and layering scheme, the hydraulic conductivity assigned to bedrock layers, recharge distribution, and water use in the form of pumping rates from glacial and bedrock wells. The construction of the inset models entailed modifying some inputs, most notably the grid spacing (reduced from cells 5,000 feet on a side in the parent LMB model to 500 feet on a side in the inset models). The refined grid spacing allowed for more precise location of pumped wells and more detailed simulation of groundwater/surface-water interactions. The glacial hydraulic conductivity values, the top bedrock surface elevation, and the surface-water network input to the inset models also were modified. The inset models are solved using the MODFLOW–NWT code, which allows for more robust handling of conditions in unconfined aquifers than previous versions of MODFLOW. Comparison of the MODFLOW inset models reveals that they incorporate a range of hydrogeologic conditions relative to the glacial part of the flow system, demonstrated by visualization and analysis of model inputs and outputs and reflected in the range of ages generated by MODPATH for existing and hypothetical glacial wells. Certain inputs and outputs are judged to be candidate predictors that, if treated statistically, may be capable of explaining much of the variance in the simulated age metrics. One example of a predictor that model results indicate strongly affects simulated age is the depth of the well open interval below the simulated water table. The strength of this example variable as an overall predictor of groundwater age and its relation to other predictors can be statistically tested through the metamodeling process. In this way the inset models are designed to serve as a training area for metamodels that estimate groundwater age in glacial wells, which in turn will contribute to ongoing studies, under the direction of the U.S. Geological Survey National Water Quality Assessment, of contaminant susceptibility of shallow groundwater across the glacial aquifer system.

Shaping electromagnetic waves using software-automatically-designed metasurfaces.

PubMed

Zhang, Qian; Wan, Xiang; Liu, Shuo; Yuan Yin, Jia; Zhang, Lei; Jun Cui, Tie

2017-06-15

We present a fully digital procedure of designing reflective coding metasurfaces to shape reflected electromagnetic waves. The design procedure is completely automatic, controlled by a personal computer. In details, the macro coding units of metasurface are automatically divided into several types (e.g. two types for 1-bit coding, four types for 2-bit coding, etc.), and each type of the macro coding units is formed by discretely random arrangement of micro coding units. By combining an optimization algorithm and commercial electromagnetic software, the digital patterns of the macro coding units are optimized to possess constant phase difference for the reflected waves. The apertures of the designed reflective metasurfaces are formed by arranging the macro coding units with certain coding sequence. To experimentally verify the performance, a coding metasurface is fabricated by automatically designing two digital 1-bit unit cells, which are arranged in array to constitute a periodic coding metasurface to generate the required four-beam radiations with specific directions. Two complicated functional metasurfaces with circularly- and elliptically-shaped radiation beams are realized by automatically designing 4-bit macro coding units, showing excellent performance of the automatic designs by software. The proposed method provides a smart tool to realize various functional devices and systems automatically.

Trends in precipitation, streamflow, reservoir pool elevations, and reservoir releases in Arkansas and selected sites in Louisiana, Missouri, and Oklahoma, 1951–2011

USGS Publications Warehouse

Wagner, Daniel M.; Krieger, Joshua D.; Merriman, Katherine R.

2014-01-01

The U.S. Geological Survey (USGS) and the U.S. Army Corps of Engineers (USACE) conducted a statistical analysis of trends in precipitation, streamflow, reservoir pool elevations, and reservoir releases in Arkansas and selected sites in Louisiana, Missouri, and Oklahoma for the period 1951–2011. The Mann-Kendall test was used to test for trends in annual and seasonal precipitation, annual and seasonal streamflows of 42 continuous-record USGS streamflow-gaging stations, annual pool elevations and releases from 16 USACE reservoirs, and annual releases from 11 dams on the Arkansas River. A statistically significant (p≤0.10) upward trend was observed in annual precipitation for the State, with a Sen slope of approximately 0.10 inch per year. Autumn and winter were the only seasons that had statistically significant trends in precipitation. Five of six physiographic sections and six of seven 4-digit hydrologic unit code (HUC) regions in Arkansas had statistically significant upward trends in autumn precipitation, with Sen slopes of approximately 0.06 to 0.10 inch per year. Sixteen sites had statistically significant upward trends in the annual mean daily streamflow and were located on streams that drained regions with statistically significant upward trends in annual precipitation. Expected annual rates of change corresponding to statistically significant trends in annual mean daily streamflows, which ranged from 0.32 to 0.88 percent, were greater than those corresponding to regions with statistically significant upward trends in annual precipitation, which ranged from 0.19 to 0.28 percent, suggesting that the observed trends in regional annual precipitation do not fully account for the observed trends in annual mean daily streamflows. Trends in annual maximum daily streamflows were similar to trends in the annual mean daily streamflows but were only statistically significant at seven sites. There were more statistically significant trends (28 of 42 sites) in the annual minimum daily streamflows than in the annual means or maximums. Statistically significant trends in the annual minimum daily streamflows were upward at 18 sites and downward at 10 sites. Despite autumn being the only season that had statistically significant upward trends in seasonal precipitation, statistically significant upward trends in seasonal mean streamflows occurred in every season but spring. Trends in the annual mean, maximum, and minimum daily pool elevations of USACE reservoirs were consistent between metrics for reservoirs in the White, Arkansas, and Ouachita River watersheds, while trends varied between metrics at DeQueen Lake, Millwood Lake, and Lake Chicot. Most of the statistically significant trends in pool elevation metrics were upward and gradual—Sen slopes were less than 0.37 foot per year—and were likely the result of changes in reservoir regulation plans. Trends in the annual mean and maximum daily releases from USACE reservoirs were generally upward in all HUC regions. There were few statistically significant trends in the annual mean daily releases because the reservoirs are operated to maintain a regulation stage at a downstream site according to guidelines set forth in the regulation plans of the reservoirs. The annual number of low-flow days was both increasing and decreasing for reservoirs in northern Arkansas and southern Missouri and generally increasing for reservoirs in southern Arkansas.

EnviroAtlas - Reptile Biodiversity Ecosystem Services Metrics by 12-digit HUC for the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset contains biodiversity metrics reflecting ecosystem services or other aspects of biodiversity for reptile species, based on the number of reptile species as measured by predicted habitat present within a pixel. These metrics were created from grouping national level single species habitat models created by the USGS Gap Analysis Program into smaller ecologically based, phylogeny based, or stakeholder suggested composites. The dataset includes reptile species richness metrics for all reptile species, lizards, snakes, turtles, poisonous reptiles, Natureserve-listed G1,G2, and G3 reptile species, and reptile species listed by IUCN (International Union for Conservation of Nature), PARC (Partners in Amphibian and Reptile Conservation) and SWPARC (Southwest Partners in Amphibian and Reptile Conservation). This dataset was produced by a joint effort of New Mexico State University, US EPA, and USGS to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa

Instruction at the Hopkins Marine Station

DTIC Science & Technology

1992-07-29

foI homtadcodnaio.. caronavirus nucleocapsid protein. wheat germ bial ~ ~ %~H2A (5), mussel sperm nuclear protein 03 [6), and man chromofsome...wvpi,~Tninev PM"p Johne HiWA~aa Unuw~rsaty &Dio of Medicine, Balw,,.vv, Manh land 21205 The two germ -line- specific Sp histione classes Treatment of...composit conical morphology of the male pronucleus- Mal, pro- serine-proline adjacent to two basic amino acids (lyo hucl*I inhibite’d with I nsMGDMAP

Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis.

PubMed

Lin, Yi-Chia; Lin, Ji-Fan; Wen, Sheng-I; Yang, Shan-Che; Tsai, Te-Fu; Chen, Hung-En; Chou, Kuang-Yu; Hwang, Thomas I-Sheng

2017-05-01

Chloroquine (CQ) and hydroxychloroquine (HCQ), two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro. The results showed that CQ and HCQ inhibited the proliferation of multiple human bladder cell lines (including RT4, 5637, and T24) in a time- and dose-dependent fashion, especially in advanced bladder cancer cell lines (5637 and T24) compared to immortalized uroepithelial cells (SV-Huc-1) or other reference cancer cell lines (PC3 and MCF-7). We found that 24-hour treatment of CQ or HCQ significantly decreased the clonogenic formation in 5637 and T24 cells compared to SV-Huc-1. As human bladder cancer tumor exhibits high basal level of autophagic activities, we detected the autophagic flux in cells treated with CQ and HCQ, showing an alternation in LC3 flux in CQ- or HCQ-treated cells. Moreover, bladder cancer cells treated with CQ and HCQ underwent apoptosis, resulting in increased caspase 3/7 activities, increased level of cleaved poly(ADP-ribose) polymerase (PARP), caspase 3, and DNA fragmentation. Given these results, targeting autophagy with CQ and HCQ represents an effective cancer therapeutic strategy against human bladder cancer. Copyright © 2017. Published by Elsevier Taiwan.

The Water-Use Implications of a Changing Power Sector

NASA Astrophysics Data System (ADS)

Peer, R.; Sanders, K.

2016-12-01

Changing policies, declining natural gas prices due to shale production and, growing pressure for cleaner energy sources are causing significant shifts in the fuels and technologies utilized for US electricity generation. These shifts have already impacted the volumes of water required for cooling thermal power plants, imposing consequences for watersheds that have yet to be quantified. This research investigates how these regulatory, economic, and socially-driven changes in the power sector have impacted cooling water usage across the US, which currently represents nearly half of US water withdrawals. This study uses plant-specific fuel consumption, generation, and cooling water data to assess water usage trends in the power sector from 2008 to 2014 across HUC-8 hydrologic units. Over this period, transitions from steam-cycle coal and nuclear units towards combined-cycle natural gas units and renewables, as well as transitions from once-through cooling towards wet recirculating tower and dry cooling systems resulted in large shifts in water usage. Trends towards non-traditional cooling water sources such as recycled water reduced freshwater consumption in some watersheds. Although US cooling water withdrawals and consumption increased from 2008 to 2014 largely due to electricity demand growth, the average water withdrawn and consumed per unit of electricity generated decreased and remained similar in magnitude, respectively. Changes at the watershed scale were not uniform, with some experiencing significant water use reductions and environmental benefits, especially due to coal-fired power plant retirements. Results highlight the importance of evaluating both water withdrawals and consumption at local spatial scales, as these shifts have varying consequences on water availability and quality for downstream users and ecosystems. This analysis underscores the importance of prioritizing local water security in global climate change adaptation and mitigation efforts.

System for loading executable code into volatile memory in a downhole tool

DOEpatents

Hall, David R.; Bartholomew, David B.; Johnson, Monte L.

2007-09-25

A system for loading an executable code into volatile memory in a downhole tool string component comprises a surface control unit comprising executable code. An integrated downhole network comprises data transmission elements in communication with the surface control unit and the volatile memory. The executable code, stored in the surface control unit, is not permanently stored in the downhole tool string component. In a preferred embodiment of the present invention, the downhole tool string component comprises boot memory. In another embodiment, the executable code is an operating system executable code. Preferably, the volatile memory comprises random access memory (RAM). A method for loading executable code to volatile memory in a downhole tool string component comprises sending the code from the surface control unit to a processor in the downhole tool string component over the network. A central processing unit writes the executable code in the volatile memory.

Controlling Energy Radiations of Electromagnetic Waves via Frequency Coding Metamaterials.

PubMed

Wu, Haotian; Liu, Shuo; Wan, Xiang; Zhang, Lei; Wang, Dan; Li, Lianlin; Cui, Tie Jun

2017-09-01

Metamaterials are artificial structures composed of subwavelength unit cells to control electromagnetic (EM) waves. The spatial coding representation of metamaterial has the ability to describe the material in a digital way. The spatial coding metamaterials are typically constructed by unit cells that have similar shapes with fixed functionality. Here, the concept of frequency coding metamaterial is proposed, which achieves different controls of EM energy radiations with a fixed spatial coding pattern when the frequency changes. In this case, not only different phase responses of the unit cells are considered, but also different phase sensitivities are also required. Due to different frequency sensitivities of unit cells, two units with the same phase response at the initial frequency may have different phase responses at higher frequency. To describe the frequency coding property of unit cell, digitalized frequency sensitivity is proposed, in which the units are encoded with digits "0" and "1" to represent the low and high phase sensitivities, respectively. By this merit, two degrees of freedom, spatial coding and frequency coding, are obtained to control the EM energy radiations by a new class of frequency-spatial coding metamaterials. The above concepts and physical phenomena are confirmed by numerical simulations and experiments.

Moving Beyond Streamflow Observations: Lessons From A Multi-Objective Calibration Experiment in the Mississippi Basin

NASA Astrophysics Data System (ADS)

Koppa, A.; Gebremichael, M.; Yeh, W. W. G.

2017-12-01

Calibrating hydrologic models in large catchments using a sparse network of streamflow gauges adversely affects the spatial and temporal accuracy of other water balance components which are important for climate-change, land-use and drought studies. This study combines remote sensing data and the concept of Pareto-Optimality to address the following questions: 1) What is the impact of streamflow (SF) calibration on the spatio-temporal accuracy of Evapotranspiration (ET), near-surface Soil Moisture (SM) and Total Water Storage (TWS)? 2) What is the best combination of fluxes that can be used to calibrate complex hydrological models such that both the accuracy of streamflow and the spatio-temporal accuracy of ET, SM and TWS is preserved? The study area is the Mississippi Basin in the United States (encompassing HUC-2 regions 5,6,7,9,10 and 11). 2003 and 2004, two climatologically average years are chosen for calibration and validation of the Noah-MP hydrologic model. Remotely sensed ET data is sourced from GLEAM, SM from ESA-CCI and TWS from GRACE. Single objective calibration is carried out using DDS Algorithm. For Multi objective calibration PA-DDS is used. First, the Noah-MP model is calibrated using a single objective function (Minimize Mean Square Error) for the outflow from the 6 HUC-2 sub-basins for 2003. Spatial correlograms are used to compare the spatial structure of ET, SM and TWS between the model and the remote sensing data. Spatial maps of RMSE and Mean Error are used to quantify the impact of calibrating streamflow on the accuracy of ET, SM and TWS estimates. Next, a multi-objective calibration experiment is setup to determine the pareto optimal parameter sets (pareto front) for the following cases - 1) SF and ET, 2) SF and SM, 3) SF and TWS, 4) SF, ET and SM, 5) SF, ET and TWS, 6) SF, SM and TWS, 7) SF, ET, SM and TWS. The best combination of fluxes that provides the optimal trade-off between accurate streamflow and preserving the spatio-temporal structure of ET, SM and TWS is then determined by validating the model outputs for the pareto-optimal parameter sets. Results from single-objective calibration experiment with streamflow shows that it does indeed negatively impact the accuracy of ET, SM and TWS estimates.

Damping Proceedings Held in Las Vegas, Nevada on 5-7 March 1986. Volume 1

DTIC Science & Technology

1986-05-01

Parin AE-1 -_ Design Oriented Measuring Techniques for Determining the Mechanical Properties of Rubber ;! Dr.lr. B. Devis, Dr.Ir. C. DeMeetsman, and...Prof,.Ir.., J. Peters AF-1 ’Selected Complex Modulus Data;JW C. Chesneau and B. Ouperray AG -I - On The Fractional Calculus Model of Viscoelastic...HUC Rubber i 0 composite material ci an elamtomeric astrf.x and iller partx Ccarbon b, ctk fibrea textiles, ... ). Although it *eem to ill

Comparative analysis of design codes for timber bridges in Canada, the United States, and Europe

Treesearch

James Wacker; James (Scott) Groenier

2010-01-01

The United States recently completed its transition from the allowable stress design code to the load and resistance factor design (LRFD) reliability-based code for the design of most highway bridges. For an international perspective on the LRFD-based bridge codes, a comparative analysis is presented: a study addressed national codes of the United States, Canada, and...

Controlling Energy Radiations of Electromagnetic Waves via Frequency Coding Metamaterials

PubMed Central

Wu, Haotian; Liu, Shuo; Wan, Xiang; Zhang, Lei; Wang, Dan; Li, Lianlin

2017-01-01

Metamaterials are artificial structures composed of subwavelength unit cells to control electromagnetic (EM) waves. The spatial coding representation of metamaterial has the ability to describe the material in a digital way. The spatial coding metamaterials are typically constructed by unit cells that have similar shapes with fixed functionality. Here, the concept of frequency coding metamaterial is proposed, which achieves different controls of EM energy radiations with a fixed spatial coding pattern when the frequency changes. In this case, not only different phase responses of the unit cells are considered, but also different phase sensitivities are also required. Due to different frequency sensitivities of unit cells, two units with the same phase response at the initial frequency may have different phase responses at higher frequency. To describe the frequency coding property of unit cell, digitalized frequency sensitivity is proposed, in which the units are encoded with digits “0” and “1” to represent the low and high phase sensitivities, respectively. By this merit, two degrees of freedom, spatial coding and frequency coding, are obtained to control the EM energy radiations by a new class of frequency‐spatial coding metamaterials. The above concepts and physical phenomena are confirmed by numerical simulations and experiments. PMID:28932671

76 FR 22003 - Delegation of Functions and Authority Under Sections 315 and 325 of Title 32, United States Code

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... Functions and Authority Under Sections 315 and 325 of Title 32, United States Code Memorandum for the... United States of America, including section 301 of title 3, United States Code, I hereby delegate to you: (a) the functions and authority of the President contained in section 315 of title 32, United States...

Short, unit-memory, Byte-oriented, binary convolutional codes having maximal free distance

NASA Technical Reports Server (NTRS)

Lee, L. N.

1975-01-01

It is shown that (n sub 0, k sub 0) convolutional codes with unit memory always achieve the largest free distance among all codes of the same rate k sub 0/n sub 0 and same number 2MK sub 0 of encoder states, where M is the encoder memory. A unit-memory code with maximal free distance is given at each place where this free distance exceeds that of the best code with k sub 0 and n sub 0 relatively prime, for all Mk sub 0 less than or equal to 6 and for R = 1/2, 1/3, 1/4, 2/3. It is shown that the unit-memory codes are byte-oriented in such a way as to be attractive for use in concatenated coding systems.

Spatial relationships of levees and wetland systems within floodplains of the Wabash Basin, USA

NASA Astrophysics Data System (ADS)

Bray, E. N.; Morrison, R. R.; Nardi, F.; Annis, A.; Dong, Q.

2017-12-01

Given the unique biogeochemical, physical, and hydrologic services provided by floodplain wetlands, proper management of river systems should include an understanding of how floodplain modifications influences wetland ecosystems. The construction of levees can reduce river-floodplain connectivity, yet it is unclear how levees affect wetlands within a river system, let alone the cumulative impacts within an entire watershed. This paper explores spatial relationships between levee and floodplain wetland systems in the Wabash basin, United States. We used a hydrogeomorphic floodplain delineation technique to map floodplain extents and identify wetlands that may be hydrologically connected to river networks. We then spatially examined the relationship between levee presence, wetland area, and other river network attributes within discrete HUC-12 sub-basins. Our results show that cumulative wetland area is relatively constant in sub-basins that contain levees, regardless of maximum stream order within the sub-basin. In sub-basins that do not contain levees, cumulative wetland area increases with maximum stream order. However, we found that wetland distributions around levees can be complex, and further studies on the influence of levees on wetland habitat may need to be evaluated at finer-resolution spatial scales.

Identifying high energy density stream-reaches through refined geospatial resolution in hydropower resource assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasha, M. Fayzul K.; Yang, Majntxov; Yeasmin, Dilruba

Benefited from the rapid development of multiple geospatial data sets on topography, hydrology, and existing energy-water infrastructures, the reconnaissance level hydropower resource assessment can now be conducted using geospatial models in all regions of the US. Furthermore, the updated techniques can be used to estimate the total undeveloped hydropower potential across all regions, and may eventually help identify further hydropower opportunities that were previously overlooked. To enhance the characterization of higher energy density stream-reaches, this paper explored the sensitivity of geospatial resolution on the identification of hydropower stream-reaches using the geospatial merit matrix based hydropower resource assessment (GMM-HRA) model. GMM-HRAmore » model simulation was conducted with eight different spatial resolutions on six U.S. Geological Survey (USGS) 8-digit hydrologic units (HUC8) located at three different terrains; Flat, Mild, and Steep. The results showed that more hydropower potential from higher energy density stream-reaches can be identified with increasing spatial resolution. Both Flat and Mild terrains exhibited lower impacts compared to the Steep terrain. Consequently, greater attention should be applied when selecting the discretization resolution for hydropower resource assessments in the future study.« less

Identifying high energy density stream-reaches through refined geospatial resolution in hydropower resource assessment

DOE PAGES

Pasha, M. Fayzul K.; Yang, Majntxov; Yeasmin, Dilruba; ...

2016-01-07

Benefited from the rapid development of multiple geospatial data sets on topography, hydrology, and existing energy-water infrastructures, the reconnaissance level hydropower resource assessment can now be conducted using geospatial models in all regions of the US. Furthermore, the updated techniques can be used to estimate the total undeveloped hydropower potential across all regions, and may eventually help identify further hydropower opportunities that were previously overlooked. To enhance the characterization of higher energy density stream-reaches, this paper explored the sensitivity of geospatial resolution on the identification of hydropower stream-reaches using the geospatial merit matrix based hydropower resource assessment (GMM-HRA) model. GMM-HRAmore » model simulation was conducted with eight different spatial resolutions on six U.S. Geological Survey (USGS) 8-digit hydrologic units (HUC8) located at three different terrains; Flat, Mild, and Steep. The results showed that more hydropower potential from higher energy density stream-reaches can be identified with increasing spatial resolution. Both Flat and Mild terrains exhibited lower impacts compared to the Steep terrain. Consequently, greater attention should be applied when selecting the discretization resolution for hydropower resource assessments in the future study.« less

Development of a Pilot Learning Module on Water Energy Nexus Using a Data-Analytic and Hypothesis-Driven Approach

NASA Astrophysics Data System (ADS)

Eldardiry, H. A.; Unruh, H. G., Sr.; Habib, E. H.; Tidwell, V. C.

2016-12-01

Recent community initiatives have identified key foundational knowledge gaps that need to be addressed before transformative solutions can be made in the area of Food, Energy and Water (FEW) nexus. In addition, knowledge gaps also exist in the area of FEW education and needs to be addressed before we can make an impact on building the next generation FEW workforces. This study reports on the development of a pilot learning-module that focuses on two elements of the FEW nexus, Energy and Water. The module follows an active-learning approach to develop a set of student-centered learning activities using FEW datasets situated in real-world settings in the contiguous US. The module is based on data-driven learning exercises that incorporate different geospatial layers and manipulate datasets at a watershed scale representing the eight-digit Hydrologic Unit Code (HUC8). Examples of such datasets include water usage by different demand sectors (available from the US Geological Survey, USGS), and power plants stratified by energy source, cooling technology, and plant capacity (available from the US Energy Information Administration, EIA). The module is structured in three sections: (1) introduction to the water and energy systems, (2) quantifying stresses on water system at a catchment scale, and (3) scenario-based analysis on the interdependencies in the water-energy systems. Following a data-analytic framework, the module guides students to make different assumptions about water use growth rates and see how these new water demands will impinge on freshwater supplies. The module engages students in analysis that examines how thermoelectric water use would depend on assumptions about future demand for electricity, power plant fuel source, cooling type, and carbon sequestration. Students vary the input parameters, observe and assess the effect on water use, and address gaps via non-potable water resources (e.g., municipal wastewater). The module is implemented using a web-based platform where datasets, lesson contents, and student learning activities are presented within a geo-spatial context. The presentation will share insight on how the dynamics of FEW systems can be taught using meaningful educational experiences that promote students' understanding of FEW systems and their complex inter-connections.

Ada Integrated Environment III Computer Program Development Specification. Volume III. Ada Optimizing Compiler.

DTIC Science & Technology

1981-12-01

file.library-unit{.subunit).SYMAP Statement Map: library-file. library-unit.subunit).SMAP Type Map: 1 ibrary.fi le. 1 ibrary-unit{.subunit). TMAP The library...generator SYMAP Symbol Map code generator SMAP Updated Statement Map code generator TMAP Type Map code generator A.3.5 The PUNIT Command The P UNIT...Core.Stmtmap) NAME Tmap (Core.Typemap) END Example A-3 Compiler Command Stream for the Code Generator Texas Instruments A-5 Ada Optimizing Compiler

Development of small molecule biosensors by coupling the recognition of the bacterial allosteric transcription factor with isothermal strand displacement amplification.

PubMed

Yao, Yongpeng; Li, Shanshan; Cao, Jiaqian; Liu, Weiwei; Fan, Keqiang; Xiang, Wensheng; Yang, Keqian; Kong, Deming; Wang, Weishan

2018-05-08

Here, we demonstrate an easy-to-implement and general biosensing strategy by coupling the small-molecule recognition of the bacterial allosteric transcription factor (aTF) with isothermal strand displacement amplification (SDA) in vitro. Based on this strategy, we developed two biosensors for the detection of an antiseptic, p-hydroxybenzoic acid, and a disease marker, uric acid, using bacterial aTF HosA and HucR, respectively, highlighting the great potential of this strategy for the development of small-molecule biosensors.

5 CFR 831.201 - Exclusions from retirement coverage.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 83 of title 5, United States Code: (1) Employees serving under appointments limited to one year or... subject to subchapter III of chapter 83 of title 5, United States Code, without a break in service or... of title 5, United States Code, except that this exclusion does not operate in the case of a member...

5 CFR 831.201 - Exclusions from retirement coverage.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 83 of title 5, United States Code: (1) Employees serving under appointments limited to one year or... subject to subchapter III of chapter 83 of title 5, United States Code, without a break in service or... of title 5, United States Code, except that this exclusion does not operate in the case of a member...

5 CFR 831.201 - Exclusions from retirement coverage.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 83 of title 5, United States Code: (1) Employees serving under appointments limited to one year or... subject to subchapter III of chapter 83 of title 5, United States Code, without a break in service or... of title 5, United States Code, except that this exclusion does not operate in the case of a member...

5 CFR 831.201 - Exclusions from retirement coverage.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 83 of title 5, United States Code: (1) Employees serving under appointments limited to one year or... subject to subchapter III of chapter 83 of title 5, United States Code, without a break in service or... of title 5, United States Code, except that this exclusion does not operate in the case of a member...

5 CFR 831.201 - Exclusions from retirement coverage.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 83 of title 5, United States Code: (1) Employees serving under appointments limited to one year or... subject to subchapter III of chapter 83 of title 5, United States Code, without a break in service or... of title 5, United States Code, except that this exclusion does not operate in the case of a member...

Codes for the identification of aquifer names and geologic units in the United States and the Caribbean outlying areas

USGS Publications Warehouse

,

1988-01-01

This standard provides codes to be used for the identification of aquifer names and geologic units in the United States, the Caribbean and other outlying areas. Outlying areas include Puerto Rico, the Virgin Islands, American Samoa, the Midway Islands, Trust Territories of the Pacific Islands, and miscellaneous Pacific Islands. Each code identifies an aquifer or rock-stratigraphic unit and its age designation. The codes provide a standardized base for use by organizations in the storage, retrieval, and exchange of ground-water data; the indexing and inventory of ground-water data and information; the cataloging of ground-water data acquisition activities; and a variety of other applications.

Codes for the identification of aquifer names and geologic units in the United States and the Caribbean outlying areas

USGS Publications Warehouse

,

1985-01-01

This standard provides codes to be used for the identification of aquifer names and geologic units in the United States, the Caribbean and other outlying areas. Outlying areas include Puerto Rico, the Virgin Islands, American Samoa, the Midway Islands, Trust Territories of the Pacific Islands, and miscellaneous Pacific Islands. Each code identifies an aquifer or rock-stratigraphic unit and its age designation. The codes provide a standardized base for use by organizations in the storage, retrieval, and exchange of ground-water data; the indexing and inventory of ground-water data and information; the cataloging of ground-water data acquisition activities; and a variety of other applications.

Prioritizing watersheds for conservation actions in the southeastern coastal plain ecoregion.

PubMed

Jang, Taeil; Vellidis, George; Kurkalova, Lyubov A; Boll, Jan; Hyman, Jeffrey B

2015-03-01

The aim of this study was to apply and evaluate a recently developed prioritization model which uses the synoptic approach to geographically prioritize watersheds in which Best Management Practices (BMPs) can be implemented to reduce water quality problems resulting from erosion and sedimentation. The model uses a benefit-cost framework to rank candidate watersheds within an ecoregion or river basin so that BMP implementation within the highest ranked watersheds will result in the most water quality improvement per conservation dollar invested. The model was developed to prioritize BMP implementation efforts in ecoregions containing watersheds associated with the USDA-NRCS Conservation Effects Assessment Project (CEAP). We applied the model to HUC-8 watersheds within the southeastern Coastal Plain ecoregion (USA) because not only is it an important agricultural area but also because it contains a well-studied medium-sized CEAP watershed which is thought to be representative of the ecoregion. The results showed that the three HUC-8 watersheds with the highest rankings (most water quality improvement expected per conservation dollar invested) were located in the southern Alabama, northern Florida, and eastern Virginia. Within these watersheds, measures of community attitudes toward conservation practices were highly ranked, and these indicators seemed to push the watersheds to the top of the rankings above other similar watersheds. The results, visualized as maps, can be used to screen and reduce the number of watersheds that need further assessment by managers and decision-makers within the study area. We anticipate that this model will allow agencies like USDA-NRCS to geographically prioritize BMP implementation efforts.

Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.

PubMed

Wang, Linli; Chen, Yuehua; Guan, Chunyan; Zhao, Zhiju; Li, Qiang; Yang, Jianguo; Mo, Jian; Wang, Bin; Wu, Wei; Yang, Xiaohui; Song, Libing; Li, Jun

2017-11-02

Because the lack of an induced pluripotent stem cell (iPSC) induction system with optimal safety and efficiency limits the application of these cells, development of such a system is important. To create such an induction system, we screened a variety of reprogrammed plasmid combinations and multiple compounds and then verified the system's feasibility using urine cells from different individuals. We also compared large-scale iPSC chromosomal variations and expression of genes associated with genomic stability between this system and the traditional episomal system using karyotype and quantitative reverse transcription polymerase chain reaction analyses. We developed a high-efficiency episomal system, the 6F/BM1-4C system, lacking tumorigenic factors for human urine-derived cell (hUC) reprogramming. This system includes six low-risk factors (6F), Oct4, Glis1, Klf4, Sox2, L-Myc, and the miR-302 cluster. Transfected hUCs were treated with four compounds (4C), inhibitor of lysine-demethylase1, methyl ethyl ketone, glycogen synthase kinase 3 beta, and histone deacetylase, within a short time period. Comparative analysis revealed significantly decreased chromosomal variation in iPSCs and significantly increased Sirt1 expression compared with iPSCs induced using the traditional episomal system. The 6F/BM1-4C system effectively induces reprogramming of urine cells in samples obtained from different individuals. iPSCs induced using the 6F/BM1-4C system are more stable at the cytogenetic level and have potential value for clinical application.

Three polypeptides screened from phage display random peptide library may be the receptor polypeptide of Mycoplasma genitalium adhesion protein.

PubMed

Deng, Xiangying; Zhu, Youcong; Dai, Pei; Yu, Minjun; Chen, Liesong; Zhu, Cuiming; You, Xiaoxing; Li, Lingling; Zeng, Yanhua

2018-04-28

Mycoplasma genitalium adhesion protein (MgPa) is a major adhesin of M. genitalium, a human pathogen associated with a series of genitourinary tract diseases. MgPa plays a very important role in M. genitalium adhering to the host cells. However, the exact receptor peptides or proteins of MgPa are still poorly understood so far. Three polypeptides (V-H-W-D-F-R-Q-W-W-Q-P-S), (D-W-S-S-W-V -Y-R-D-P-Q-T) and (H-Y-I-D-F-R-W) were previously screened from a phage display random peptide library using recombinant MgPa (rMgPa) as a target molecule. In this study, three polypeptides were artificially synthesized and investigated as to whether they are potential receptors of MgPa. We found that rMgPa specifically bound to three synthesized polypeptides as determined via an indirect enzyme-linked immunosorbent assay (ELISA). Moreover, three polypeptides were further identified by indirect immunofluorescence microscopy (IFM). We confirmed that rMgPa and M. genitalium can adhere to SV-HUC-1 cells in vitro and that anti-rMgPa antibody and three synthesized polypeptides can partially inhibit the adherence of rMgPa and M. genitalium to SV-HUC-1 cells. In summary, these three polypeptides may be the essential receptor peptides of MgPa, and may aid in enhancing the understanding of biological function of MgPa and the possible pathogenic mechanism of M. genitalium. Copyright © 2018 Elsevier Ltd. All rights reserved.

Long-Term Grazing Exclusion Improves the Composition and Stability of Soil Organic Matter in Inner Mongolian Grasslands

PubMed Central

Wang, Chunyan; He, Nianpeng; Zhang, Jinjing; Lv, Yuliang; Wang, Li

2015-01-01

Alteration of the composition of soil organic matter (SOM) in Inner Mongolian grassland soils associated with the duration of grazing exclusion (GE) has been considered an important index for evaluating the restoring effects of GE practice. By using five plots from a grassland succession series from free grazing to 31-year GE, we measured the content of soil organic carbon (SOC), humic acid carbon (HAC), fulvic acid carbon (FAC), humin carbon (HUC), and humic acid structure to evaluate the changes in SOM composition. The results showed that SOC, HUC, and the ratios of HAC/FAC and HAC/extractable humus carbon (C) increased significantly with prolonged GE duration, and their relationships can be well fitted by positive exponential equations, except for FAC. In contrast, the HAC content increased logarithmically with prolonged GE duration. Long-term GE enhanced the content of SOC and soil humification, which was obvious after more than 10 years of GE. Solid-state 13C nuclear magnetic resonance spectroscopy showed that the ratios of alkyl C/O-alkyl C first decreased, and then remained stable with prolonged GE. Alternately, the ratios of aromaticity and hydrophobicity first increased, and then were maintained at relatively stable levels. Thus, a decade of GE improved the composition and structure of SOM in semiarid grassland soil and made it more stable. These findings provide new evidence to support the positive effects of long-term GE on soil SOC sequestration in the Inner Mongolian grasslands, in view of the improvement of SOM structure and stability. PMID:26057249

Long-Term Grazing Exclusion Improves the Composition and Stability of Soil Organic Matter in Inner Mongolian Grasslands.

PubMed

Wang, Chunyan; He, Nianpeng; Zhang, Jinjing; Lv, Yuliang; Wang, Li

2015-01-01

Alteration of the composition of soil organic matter (SOM) in Inner Mongolian grassland soils associated with the duration of grazing exclusion (GE) has been considered an important index for evaluating the restoring effects of GE practice. By using five plots from a grassland succession series from free grazing to 31-year GE, we measured the content of soil organic carbon (SOC), humic acid carbon (HAC), fulvic acid carbon (FAC), humin carbon (HUC), and humic acid structure to evaluate the changes in SOM composition. The results showed that SOC, HUC, and the ratios of HAC/FAC and HAC/extractable humus carbon (C) increased significantly with prolonged GE duration, and their relationships can be well fitted by positive exponential equations, except for FAC. In contrast, the HAC content increased logarithmically with prolonged GE duration. Long-term GE enhanced the content of SOC and soil humification, which was obvious after more than 10 years of GE. Solid-state 13C nuclear magnetic resonance spectroscopy showed that the ratios of alkyl C/O-alkyl C first decreased, and then remained stable with prolonged GE. Alternately, the ratios of aromaticity and hydrophobicity first increased, and then were maintained at relatively stable levels. Thus, a decade of GE improved the composition and structure of SOM in semiarid grassland soil and made it more stable. These findings provide new evidence to support the positive effects of long-term GE on soil SOC sequestration in the Inner Mongolian grasslands, in view of the improvement of SOM structure and stability.

Sectoral Vulnerabilities to Changing Water Resources: Current and Future Tradeoffs between Supply and Demand in the Conterminous U.S

NASA Astrophysics Data System (ADS)

Meldrum, J.; Averyt, K.; Caldwell, P.; Sun, G.; Huber-lee, A. T.; McNulty, S.

2012-12-01

Assessing the sustainability of human activities depends, in part, on the availability of water supplies to meet the demands of those activities. Thermoelectric cooling, agriculture, and municipal uses all compete for water supplies, but each sector differs in its characteristic ratio of water consumption versus withdrawals. This creates different implications for contributing to water supply stress and, conversely, vulnerabilities within each sector to changing water supplies. In this study, we use two measures of water stress, relating to water withdrawals and to water consumption, and calculate the role of each of these three sectors in contributing to the two different measures. We estimate water stress with an enhanced version of the Water Supply Stress Index (WaSSI), calculating the ratio of water demand to water supply at the 8-digit Hydrologic Unit Code (HUC) scale (Sun et al. 2008, 2011; Caldwell et al. 2011). Current water supplies are based on an integrated water balance and flow routing model of the conterminous United States, which accounts for surface water supply, groundwater supply, and major return flows. Future supplies are based on simulated regional changes in streamflow in 2050 from an ensemble of 12 climate models (Milly et al. 2005). We estimate water demands separately for agriculture, municipal uses, and thermoelectric cooling, with the first two based on Kenny et al. (2005) and the last on the approach of Averyt et al. (2011). We find substantial regional variation not only in the overall WaSSI for withdrawals and consumption but also in contribution of the three water use sectors to that total. Results suggest that the relative vulnerabilities of different sectors of human activity to water supply stress vary spatially and that policies for alleviating that stress must consider the specific, regional context of the tradeoffs between competing water demands. Ref's: Averyt, K., Fisher, J., Huber-Lee, A., Lewis, A., Macknick, J., Madden, N., Rogers, J., and Tellinghuisen, S. 2011. Freshwater use by US power plants: electricity's thirst for a precious resource. A report of the Energy and Water in a Warming World initiative, Cambridge, MA: Union of Concerned Scientists, 52 pp. Caldwell, P., Sun, G., McNulty, S., Cohen, E., and Moore Myers, J. 2011. Modeling Impacts of Environmental Change on Ecosystem Services across the Conterminous United States, in: Proceedings of the Fourth Interagency Conference on Research in the Watersheds, Fairbanks, AK, 26-30 Sept 2011, 63-69. Kenny, J., Barber, N., Hutson, S., Linsey, K., Lovelace, J., and Maupin, M. 2009. Estimated use of water in the United States in 2005. US Geological Survey Circular 1344, 52 pp. Milly, P. C. D., Dunne, K. A., and Vecchia, A. V. 2005. Global pattern of trends in streamflow and water availability in a changing climate. Nature 438(7066):347-350. Sun, G., McNulty, S., Moore Myers, J., and Cohen, E. 2008. Impacts of multiple stresses on water demand and supply across the Southeastern United States. Journal of American Water Resources Association 44(6):1441-1457. Sun, G., Caldwell, P., Noormets, A., Cohen, E., McNulty, S., Treasure, E., Domec, J., Mu, Q., Xiao, J., John, R., and Chen, J. 2011. Upscaling key ecosystem functions across the Conterminous United States by a water-centric ecosystem model, J. Geophys. Res., 116.

Some partial-unit-memory convolutional codes

NASA Technical Reports Server (NTRS)

Abdel-Ghaffar, K.; Mceliece, R. J.; Solomon, G.

1991-01-01

The results of a study on a class of error correcting codes called partial unit memory (PUM) codes are presented. This class of codes, though not entirely new, has until now remained relatively unexplored. The possibility of using the well developed theory of block codes to construct a large family of promising PUM codes is shown. The performance of several specific PUM codes are compared with that of the Voyager standard (2, 1, 6) convolutional code. It was found that these codes can outperform the Voyager code with little or no increase in decoder complexity. This suggests that there may very well be PUM codes that can be used for deep space telemetry that offer both increased performance and decreased implementational complexity over current coding systems.

Concatenated coding systems employing a unit-memory convolutional code and a byte-oriented decoding algorithm

NASA Technical Reports Server (NTRS)

Lee, L.-N.

1977-01-01

Concatenated coding systems utilizing a convolutional code as the inner code and a Reed-Solomon code as the outer code are considered. In order to obtain very reliable communications over a very noisy channel with relatively modest coding complexity, it is proposed to concatenate a byte-oriented unit-memory convolutional code with an RS outer code whose symbol size is one byte. It is further proposed to utilize a real-time minimal-byte-error probability decoding algorithm, together with feedback from the outer decoder, in the decoder for the inner convolutional code. The performance of the proposed concatenated coding system is studied, and the improvement over conventional concatenated systems due to each additional feature is isolated.

Concatenated coding systems employing a unit-memory convolutional code and a byte-oriented decoding algorithm

NASA Technical Reports Server (NTRS)

Lee, L. N.

1976-01-01

Concatenated coding systems utilizing a convolutional code as the inner code and a Reed-Solomon code as the outer code are considered. In order to obtain very reliable communications over a very noisy channel with relatively small coding complexity, it is proposed to concatenate a byte oriented unit memory convolutional code with an RS outer code whose symbol size is one byte. It is further proposed to utilize a real time minimal byte error probability decoding algorithm, together with feedback from the outer decoder, in the decoder for the inner convolutional code. The performance of the proposed concatenated coding system is studied, and the improvement over conventional concatenated systems due to each additional feature is isolated.

3 CFR - Delegation of Reporting Functions Specified in Section 491 of Title 10, United State Code

Code of Federal Regulations, 2014 CFR

2014-01-01

... 3 The President 1 2014-01-01 2014-01-01 false Delegation of Reporting Functions Specified in Section 491 of Title 10, United State Code Presidential Documents Other Presidential Documents Memorandum of June 19, 2013 Delegation of Reporting Functions Specified in Section 491 of Title 10, United State Code Memorandum for the Secretary of Defense B...

3 CFR - Delegation of Functions and Authority Under Sections 315 and 325 of Title 32, United States Code

Code of Federal Regulations, 2012 CFR

2012-01-01

... 3 The President 1 2012-01-01 2012-01-01 false Delegation of Functions and Authority Under Sections 315 and 325 of Title 32, United States Code Presidential Documents Other Presidential Documents Memorandum of April 14, 2011 Delegation of Functions and Authority Under Sections 315 and 325 of Title 32, United States Code Memorandum for the...

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation

PubMed Central

Uppugunduri, Chakradhara Rao S.; Storelli, Flavia; Mlakar, Vid; Huezo-Diaz Curtis, Patricia; Rezgui, Aziz; Théorêt, Yves; Marino, Denis; Doffey-Lazeyras, Fabienne; Chalandon, Yves; Bader, Peter; Daali, Youssef; Bittencourt, Henrique; Krajinovic, Maja; Ansari, Marc

2017-01-01

Hemorrhagic cystitis (HC) is one of the complications of busulfan-cyclophosphamide (BU-CY) conditioning regimen during allogeneic hematopoietic stem cell transplantation (HSCT) in children. Identifying children at high risk of developing HC in a HSCT setting could facilitate the evaluation and implementation of effective prophylactic measures. In this retrospective analysis genotyping of selected candidate gene variants was performed in 72 children and plasma Sulfolane (Su, water soluble metabolite of BU) levels were measured in 39 children following treatment with BU-CY regimen. The cytotoxic effects of Su and acrolein (Ac, water soluble metabolite of CY) were tested on human urothelial cells (HUCs). The effect of Su was also tested on cytochrome P 450 (CYP) function in HepaRG hepatic cells. Cumulative incidences of HC before day 30 post HSCT were estimated using Kaplan–Meier curves and log-rank test was used to compare the difference between groups in a univariate analysis. Multivariate Cox regression was used to estimate hazard ratios with 95% confidence intervals (CIs). Multivariate analysis included co-variables that were significantly associated with HC in a univariate analysis. Cumulative incidence of HC was 15.3%. In the univariate analysis, HC incidence was significantly (p < 0.05) higher in children older than 10 years (28.6 vs. 6.8%) or in children with higher Su levels (>40 vs. <11%) or in carriers of both functional GSTM1 and CYP2C9 (33.3 vs. 6.3%) compared to the other group. In a multivariate analysis, combined GSTM1 and CYP2C9 genotype status was associated with HC occurrence with a hazards ratio of 4.8 (95% CI: 1.3–18.4; p = 0.02). Ac was found to be toxic to HUC cells at lower concentrations (33 μM), Su was not toxic to HUC cells at concentrations below 1 mM and did not affect CYP function in HepaRG cells. Our observations suggest that pre-emptive genotyping of CYP2C9 and GSTM1 may aid in selection of more effective prophylaxis to reduce HC development in pediatric patients undergoing allogeneic HSCT. Article summary: (1) Children carrying functional alleles in GSTM1 and CYP2C9 are at high risk for developing hemorrhagic cystitis following treatment with busulfan and cyclophosphamide based conditioning regimen. (2) Identification of children at high risk for developing hemorrhagic cystitis in an allogeneic HSCT setting will enable us to evaluate and implement optimal strategies for its prevention. Trial registration: This study is a part of the trail “clinicaltrials.gov identifier: NCT01257854.” PMID:28744217

The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation.

PubMed

Uppugunduri, Chakradhara Rao S; Storelli, Flavia; Mlakar, Vid; Huezo-Diaz Curtis, Patricia; Rezgui, Aziz; Théorêt, Yves; Marino, Denis; Doffey-Lazeyras, Fabienne; Chalandon, Yves; Bader, Peter; Daali, Youssef; Bittencourt, Henrique; Krajinovic, Maja; Ansari, Marc

2017-01-01

Hemorrhagic cystitis (HC) is one of the complications of busulfan-cyclophosphamide (BU-CY) conditioning regimen during allogeneic hematopoietic stem cell transplantation (HSCT) in children. Identifying children at high risk of developing HC in a HSCT setting could facilitate the evaluation and implementation of effective prophylactic measures. In this retrospective analysis genotyping of selected candidate gene variants was performed in 72 children and plasma Sulfolane (Su, water soluble metabolite of BU) levels were measured in 39 children following treatment with BU-CY regimen. The cytotoxic effects of Su and acrolein (Ac, water soluble metabolite of CY) were tested on human urothelial cells (HUCs). The effect of Su was also tested on cytochrome P 450 (CYP) function in HepaRG hepatic cells. Cumulative incidences of HC before day 30 post HSCT were estimated using Kaplan-Meier curves and log-rank test was used to compare the difference between groups in a univariate analysis. Multivariate Cox regression was used to estimate hazard ratios with 95% confidence intervals (CIs). Multivariate analysis included co-variables that were significantly associated with HC in a univariate analysis. Cumulative incidence of HC was 15.3%. In the univariate analysis, HC incidence was significantly ( p < 0.05) higher in children older than 10 years (28.6 vs. 6.8%) or in children with higher Su levels (>40 vs. <11%) or in carriers of both functional GSTM1 and CYP2C9 (33.3 vs. 6.3%) compared to the other group. In a multivariate analysis, combined GSTM1 and CYP2C9 genotype status was associated with HC occurrence with a hazards ratio of 4.8 (95% CI: 1.3-18.4; p = 0.02). Ac was found to be toxic to HUC cells at lower concentrations (33 μM), Su was not toxic to HUC cells at concentrations below 1 mM and did not affect CYP function in HepaRG cells. Our observations suggest that pre-emptive genotyping of CYP2C9 and GSTM1 may aid in selection of more effective prophylaxis to reduce HC development in pediatric patients undergoing allogeneic HSCT. Article summary : (1) Children carrying functional alleles in GSTM1 and CYP2C9 are at high risk for developing hemorrhagic cystitis following treatment with busulfan and cyclophosphamide based conditioning regimen. (2) Identification of children at high risk for developing hemorrhagic cystitis in an allogeneic HSCT setting will enable us to evaluate and implement optimal strategies for its prevention. Trial registration : This study is a part of the trail "clinicaltrials.gov identifier: NCT01257854."

Unit Testing for the Application Control Language (ACL) Software

NASA Technical Reports Server (NTRS)

Heinich, Christina Marie

2014-01-01

In the software development process, code needs to be tested before it can be packaged for release in order to make sure the program actually does what it says is supposed to happen as well as to check how the program deals with errors and edge cases (such as negative or very large numbers). One of the major parts of the testing process is unit testing, where you test specific units of the code to make sure each individual part of the code works. This project is about unit testing many different components of the ACL software and fixing any errors encountered. To do this, mocks of other objects need to be created and every line of code needs to be exercised to make sure every case is accounted for. Mocks are important to make because it gives direct control of the environment the unit lives in instead of attempting to work with the entire program. This makes it easier to achieve the second goal of exercising every line of code.

Effects of Climate Change on Flood Frequency in the Pacific Northwest

NASA Astrophysics Data System (ADS)

Gergel, D. R.; Stumbaugh, M. R.; Lee, S. Y.; Nijssen, B.; Lettenmaier, D. P.

2014-12-01

A key concern about climate change as related to water resources is the potential for changes in hydrologic extremes, including flooding. We explore changes in flood frequency in the Pacific Northwest using downscaled output from ten Global Climate Models (GCMs) from the Coupled Model Inter-Comparison Project 5 (CMIP5) for historical forcings (1950-2005) and future Representative Concentration Pathways (RCPs) 4.5 and 8.5 (2006-2100). We use archived output from the Integrated Scenarios Project (ISP) (http://maca.northwestknowledge.net/), which uses the Multivariate Adaptive Constructed Analogs (MACA) method for statistical downscaling. The MACA-downscaled GCM output was then used to force the Variable Infiltration Capacity (VIC) hydrology model with a 1/16th degree spatial resolution and a daily time step. For each of the 238 HUC-08 areas within the Pacific Northwest (USGS Hydrologic Region 15), we computed, from the ISP archive, the series of maximum daily runoff values (surrogate for the annual maximum flood), and then the mean annual flood. Finally, we computed the ratios of the RCP4.5 and RCP8.5 mean annual floods to their corresponding values for the historical period. We evaluate spatial patterns in the results. For snow-dominated watersheds, the changes are dominated by reductions in flood frequency in basins that currently have spring-dominant floods, and increases in snow affected basins with fall-dominant floods. In low elevation basins west of the Cascades, changes in flooding are more directly related to changes in precipitation extremes. We further explore the nature of these effects by evaluating the mean Julian day of the annual maximum flood for each HUC-08 and how this changes between the historical and RCP4.5 and RCP8.5 scenarios.

Ketamine-induced bladder fibrosis involves epithelial-to-mesenchymal transition mediated by transforming growth factor-β1.

PubMed

Wang, Junpeng; Chen, Yang; Gu, Di; Zhang, Guihao; Chen, Jiawei; Zhao, Jie; Wu, Peng

2017-10-01

Bladder wall fibrosis is a major complication of ketamine-induced cystitis (KC), but the underlying pathogenesis is poorly understood. The aim of the present study was to elucidate the mechanism of ketamine-induced fibrosis in association with epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor-β1 (TGF-β1). Sprague-Dawley rats were randomly distributed into four groups, which received saline, ketamine, ketamine combined with a TGF-β receptor inhibitor (SB-505124) for 16 wk, or 12 wk of ketamine and 4 wk of abstinence. In addition, the profibrotic effect of ketamine was confirmed in SV-40 immortalized human uroepithelial (SV-HUC-1) cells. The ketamine-treated rats displayed voiding dysfunction and decreased bladder compliance. Bladder fibrosis was accompanied by the appearance of a certain number of cells expressing both epithelial and mesenchymal markers, indicating that epithelial cells might undergo EMT upon ketamine administration. Meanwhile, the expression level of TGF-β1 was significantly upregulated in the urothelium of bladders in ketamine-treated rats. Treatment of SV-HUC-1 cells with ketamine increased the expression of TGF-β1 and EMT-inducing transcription factors, resulting in the downregulation of E-cadherin and upregulation of fibronectin and α-smooth muscle actin. Administration of SB-505124 inhibited EMT and fibrosis both in vitro and vivo. In addition, withdrawal from ketamine did not lead to recovery of bladder urinary function or decreased fibrosis. Taken together, our study shows for the first time that EMT might contribute to bladder fibrosis in KC. TGF-β1 may have an important role in bladder fibrogenesis via an EMT mechanism. Copyright © 2017 the American Physiological Society.

Vasculogenic mimicry in bladder cancer and its association with the aberrant expression of ZEB1

PubMed Central

Li, Baimou; Mao, Xiaopeng; Wang, Hua; Su, Guanyu; Mo, Chengqiang; Cao, Kaiyuan; Qiu, Shaopeng

2018-01-01

The aim of the present study was to investigate the associations between vasculogenic mimicry (VM) and zinc finger E-box binding homeobox 1 (ZEB1) in bladder cancer. VM structure and ZEB1 expression were analyzed by cluster of differentiation 34/periodic acid Schiff (PAS) double staining and immunohistochemical staining in 135 specimens from patients with bladder cancer, and a further 12 specimens from normal bladder tissues. Three-dimensional (3-D) culture was used to detect VM formation in the bladder transitional cancer cell lines UM-UC-3 and J82, and the immortalized human bladder epithelium cell line SV-HUC-1 in vitro. ZEB1 expression in these cell lines was compared by reverse transcription-quantitative polymerase chain reaction and western blot assays. In addition, small interfering RNA was used to inhibit ZEB1 in UM-UC-3 and J82 cells, followed by 3-D culturing of treated cell lines. As a result, VM was observed in 31.1% of specimens from bladder cancer tissues, and cases with high ZEB1 expression accounted for 60.0% of patients with bladder cancer. In addition, ZEB1 expression was closely associated with VM (r=0.189; P<0.05), and also increased as the grade and stage of the tumor developed. In an in vitro assay, UM-UC-3 and J82 cells exhibited VM formation, however, SV-HUC-1 did not. Furthermore, VM-forming cancer cell lines UM-UC-3 and J82 exhibited higher ZEB1 expression. Notably, VM formation was inhibited following knockdown of ZEB1. In conclusion, ZEB1 may be associated with VM in bladder cancer and serve an important role in the process of VM formation. However, its detailed mechanism requires further study. PMID:29552157

Error control techniques for satellite and space communications

NASA Technical Reports Server (NTRS)

Costello, Daniel J., Jr.

1992-01-01

Worked performed during the reporting period is summarized. Construction of robustly good trellis codes for use with sequential decoding was developed. The robustly good trellis codes provide a much better trade off between free distance and distance profile. The unequal error protection capabilities of convolutional codes was studied. The problem of finding good large constraint length, low rate convolutional codes for deep space applications is investigated. A formula for computing the free distance of 1/n convolutional codes was discovered. Double memory (DM) codes, codes with two memory units per unit bit position, were studied; a search for optimal DM codes is being conducted. An algorithm for constructing convolutional codes from a given quasi-cyclic code was developed. Papers based on the above work are included in the appendix.

77 FR 43103 - Policy on the 2009 Revision of the International Maritime Organization Code for the Construction...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-23

... Offshore Drilling Units AGENCY: Coast Guard, DHS. ACTION: Notice of availability. SUMMARY: The Coast Guard...), Code for the Construction and Equipment of Mobile Offshore Drilling Units, 2009 (2009 MODU Code). CG...: Background and Purpose Foreign documented MODUs engaged in any offshore activity associated with the...

3 CFR 13593 - Executive Order 13593 of December 13, 2011. 2011 Amendments to the Manual for Courts-Martial...

Code of Federal Regulations, 2012 CFR

2012-01-01

... United States of America, including chapter 47 of title 10, United States Code (Uniform Code of Military Justice, 10 U.S.C. 801-946), and in order to prescribe amendments to the Manual for Courts-Martial, United...

3 CFR 13643 - Executive Order 13643 of May 15, 2013. 2013 Amendments to the Manual for Courts-Martial, United...

Code of Federal Regulations, 2014 CFR

2014-01-01

... States of America, including chapter 47 of title 10, United States Code (Uniform Code of Military Justice, 10 U.S.C. 801-946), and in order to prescribe amendments to the Manual for Courts-Martial, United...

Coordinated design of coding and modulation systems

NASA Technical Reports Server (NTRS)

Massey, J. L.

1976-01-01

Work on partial unit memory codes continued; it was shown that for a given virtual state complexity, the maximum free distance over the class of all convolutional codes is achieved within the class of unit memory codes. The effect of phase-lock loop (PLL) tracking error on coding system performance was studied by using the channel cut-off rate as the measure of quality of a modulation system. Optimum modulation signal sets for a non-white Gaussian channel considered an heuristic selection rule based on a water-filling argument. The use of error correcting codes to perform data compression by the technique of syndrome source coding was researched and a weight-and-error-locations scheme was developed that is closely related to LDSC coding.

A tactile-output paging communication system for the deaf-blind

NASA Technical Reports Server (NTRS)

Baer, J. A.

1979-01-01

A radio frequency paging communication system that has coded vibrotactile outputs suitable for use by deaf-blind people was developed. In concept, the system consists of a base station transmitting and receiving unit and many on-body transmitting and receiving units. The completed system has seven operating modes: fire alarm; time signal; repeated single character Morse code; manual Morse code; emergency aid request; operational status test; and message acknowledge. The on-body units can be addressed in three ways: all units; a group of units; or an individual unit. All the functions developed were integrated into a single package that can be worn on the user's wrist. The control portion of the on-body unit is implemented by a microcomputer. The microcomputer is packaged in a custom-designed hybrid circuit to reduce its physical size.

Impacts of impervious cover, water withdrawals, and climate change on river flows in the conterminous US

NASA Astrophysics Data System (ADS)

Caldwell, P. V.; Sun, G.; McNulty, S. G.; Cohen, E. C.; Moore Myers, J. A.

2012-08-01

Rivers are essential to aquatic ecosystem and societal sustainability, but are increasingly impacted by water withdrawals, land-use change, and climate change. The relative and cumulative effects of these stressors on continental river flows are relatively unknown. In this study, we used an integrated water balance and flow routing model to evaluate the impacts of impervious cover and water withdrawal on river flow across the conterminous US at the 8-digit Hydrologic Unit Code (HUC) watershed scale. We then estimated the impacts of projected change in withdrawals, impervious cover, and climate under the B1 "Low" and A2 "High" emission scenarios on river flows by 2060. Our results suggest that compared to no impervious cover, 2010 levels of impervious cover increased river flows by 9.9% on average with larger impacts in and downstream of major metropolitan areas. In contrast, compared to no water withdrawals, 2005 withdrawals decreased river flows by 1.4% on average with larger impacts in heavily irrigated arid regions of Western US. By 2060, impacts of climate change were predicted to overwhelm the potential gain in river flow due to future changes in impervious cover and add to the potential reduction in river flows from withdrawals, decreasing mean annual river flows from 2010 levels by 16% on average. However, increases in impervious cover by 2060 may offset the impact of climate change during the growing season in some watersheds. Large water withdrawals will aggravate the predicted impact of climate change on river flows, particularly in the Western US. Predicted ecohydrological impacts of land cover, water withdrawal, and climate change will likely include alteration of the terrestrial water balance, stream channel habitat, riparian and aquatic community structure in snow-dominated basins, and fish and mussel extirpations in heavily impacted watersheds. These changes may also require new infrastructure to support increasing anthropogenic demand for water, relocation of agricultural production, and/or water conservation measures. Given that the impacts of land use, withdrawals and climate may be either additive or offsetting in different magnitudes, integrated and spatially explicit modeling and management approaches are necessary to effectively manage water resources for aquatic life and human use in the face of global change.

42 CFR 414.46 - Additional rules for payment of anesthesia services.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... (a) Definitions. For purposes of this section, the following definitions apply: (1) Base unit means the value for each anesthesia code that reflects all activities other than anesthesia time. These... furnishes the carrier with the base units for each anesthesia procedure code. The base units are derived...

42 CFR 414.46 - Additional rules for payment of anesthesia services.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... (a) Definitions. For purposes of this section, the following definitions apply: (1) Base unit means the value for each anesthesia code that reflects all activities other than anesthesia time. These... furnishes the carrier with the base units for each anesthesia procedure code. The base units are derived...

40 CFR 62.15265 - How do I monitor the load of my municipal waste combustion unit?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Mechanical Engineers (ASME PTC 4.1—1964): Test Code for Steam Generating Units, Power Test Code 4.1-1964... of Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You....archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. (4) Design, construct...

40 CFR 62.15265 - How do I monitor the load of my municipal waste combustion unit?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Mechanical Engineers (ASME PTC 4.1—1964): Test Code for Steam Generating Units, Power Test Code 4.1-1964... of Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You....archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. (4) Design, construct...

40 CFR 62.15265 - How do I monitor the load of my municipal waste combustion unit?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mechanical Engineers (ASME PTC 4.1—1964): Test Code for Steam Generating Units, Power Test Code 4.1-1964... of Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You....archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. (4) Design, construct...

40 CFR 62.15265 - How do I monitor the load of my municipal waste combustion unit?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Mechanical Engineers (ASME PTC 4.1—1964): Test Code for Steam Generating Units, Power Test Code 4.1-1964... of Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You....archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. (4) Design, construct...

40 CFR 62.15265 - How do I monitor the load of my municipal waste combustion unit?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Mechanical Engineers (ASME PTC 4.1—1964): Test Code for Steam Generating Units, Power Test Code 4.1-1964... of Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You....archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. (4) Design, construct...

Effects of Climate Change on Extreme Streamflow Risks in the Olympic National Park

NASA Astrophysics Data System (ADS)

Tohver, I. M.; Lee, S.; Hamlet, A.

2011-12-01

Conventionally, natural resource management practices are designed within the framework that past conditions serve as a baseline for future conditions. However, the warmer future climate projected for the Pacific Northwest will alter the region's flood and low flow risks, posing considerable challenges to resource managers in the Olympic National Forest (ONF) and Olympic National Park (ONP). Shifts in extreme streamflow will influence two key management objectives in the ONF and ONP: the protection of wildlife and the maintenance of road infrastructure. The ONF is charged with managing habitat for species listed under the Endangered Species Act (ESA), and with maintaining the network of forest roads and culverts. Climate-induced increases in flood severity will introduce additional challenges in road and culvert design. Furthermore, the aging road infrastructure and more extreme summer low flows will compromise aquatic habitats, intrinsic to the health of threatened and endangered fish species listed under the ESA. Current practice uses estimates of Q100 (or the peak flow with an estimated 100 year return frequency) as the standard metric for stream crossing design. Simple regression models relating annual precipitation and basin area to Q100 are used in the design process. Low flow estimates are based on historical streamflow data to calculate the 7-day consecutive lowest flow with a 10-year return interval, or 7Q10. Under the projections a changing climate, these methods for estimating extreme flows are ill equipped to capture the complex and spatially varying effects of seasonal changes in temperature, precipitation, and snowpack on extreme flow risk. As an alternative approach, this study applies a physically-based hydrologic model to estimate historical and future flood risk at 1/16th degree (latitude/longitude) resolution (about 32 km2). We downscaled climate data derived from 10 global climate models to use as input for the Variable Infiltration Capacity (VIC) model, a macro-scale hydrologic model, which simulates various hydrologic variables at a daily time step. Using the VIC estimates for baseflow and run-off, we calculated Q100 and 7Q10 for the historical period and under two emission scenarios, A1B and B1, at three future time intervals: the 2020s, the 2040s and the 2080s. We also calculated Q100 and 7Q10 at the spatial scale of the 12-digit hydrologic unit codes (HUCs) as delineated by the United States Geologic Survey. The results demonstrate the sensitivity of snowpack at mid-elevation basins to a warmer climate, resulting in more severe winter flooding and lower streamflows in the summertime. These ensemble estimates of extreme streamflows will serve as a tool for management practices by providing high-resolution maps of changing risk over the ONF and ONP.

Increasing Trend of Fatal Falls in Older Adults in the United States, 1992 to 2005: Coding Practice or Reporting Quality?

PubMed

Kharrazi, Rebekah J; Nash, Denis; Mielenz, Thelma J

2015-09-01

To investigate whether changes in death certificate coding and reporting practices explain part or all of the recent increase in the rate of fatal falls in adults aged 65 and older in the United States. Trends in coding and reporting practices of fatal falls were evaluated under mortality coding schemes for International Classification of Diseases (ICD), Ninth Revision (1992-1998) and Tenth Revision (1999-2005). United States, 1992 to 2005. Individuals aged 65 and older with falls listed as the underlying cause of death (UCD) on their death certificates. The primary outcome was annual fatal falls rates per 100,000 U.S. residents aged 65 and older. Coding practice was assessed through analysis of trends in rates of specific UCD fall ICD e-codes over time. Reporting quality was assessed by examining changes in the location on the death certificate where fall e-codes were reported, in particular, the percentage of fall e-codes recorded in the proper location on the death certificate. Fatal falls rates increased over both time periods: 1992 to 1998 and 1999 to 2005. A single falls e-code was responsible for the increasing trend of fatal falls overall from 1992 to 1998 (E888, other and unspecified fall) and from 1999 to 2005 (W18, other falls on the same level), whereas trends for other falls e-codes remained stable. Reporting quality improved steadily throughout the study period. Better reporting quality, not coding practices, contributed to the increasing rate of fatal falls in older adults in the United States from 1992 to 2005. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

48 CFR 52.204-18 - Commercial and Government Entity Code Maintenance.

Code of Federal Regulations, 2014 CFR

2014-10-01

... assigned to entities located in the United States or its outlying areas by the Defense Logistics Agency... NATO Support Agency (NSPA) to entities located outside the United States and its outlying areas that... code on the contract. (c) Contractors located in the United States or its outlying areas that are not...

Theory of epigenetic coding.

PubMed

Elder, D

1984-06-07

The logic of genetic control of development may be based on a binary epigenetic code. This paper revises the author's previous scheme dealing with the numerology of annelid metamerism in these terms. Certain features of the code had been deduced to be combinatorial, others not. This paradoxical contrast is resolved here by the interpretation that these features relate to different operations of the code; the combinatiorial to coding identity of units, the non-combinatorial to coding production of units. Consideration of a second paradox in the theory of epigenetic coding leads to a new solution which further provides a basis for epimorphic regeneration, and may in particular throw light on the "regeneration-duplication" phenomenon. A possible test of the model is also put forward.

Numerical Electromagnetic Code (NEC)-Basic Scattering Code. Part 2. Code Manual

DTIC Science & Technology

1979-09-01

imaging of source axes for magnetic source. Ax R VSOURC(1,1) + 9 VSOURC(1,2) + T VSOURC(1,3) 4pi = x VIMAG(I,1) + ^ VINAG (1,2)+ VIMAG(l,3) An =unit...VNC A. yt and z components of the end cap unit normal OUTPUT VARIABLE VINAG X.. Y, and z components defining thesource image coordinate system axesin

Transfer Function Bounds for Partial-unit-memory Convolutional Codes Based on Reduced State Diagram

NASA Technical Reports Server (NTRS)

Lee, P. J.

1984-01-01

The performance of a coding system consisting of a convolutional encoder and a Viterbi decoder is analytically found by the well-known transfer function bounding technique. For the partial-unit-memory byte-oriented convolutional encoder with m sub 0 binary memory cells and (k sub 0 m sub 0) inputs, a state diagram of 2(K) (sub 0) was for the transfer function bound. A reduced state diagram of (2 (m sub 0) +1) is used for easy evaluation of transfer function bounds for partial-unit-memory codes.

Novel variants of the 5S rRNA genes in Eruca sativa.

PubMed

Singh, K; Bhatia, S; Lakshmikumaran, M

1994-02-01

The 5S ribosomal RNA (rRNA) genes of Eruca sativa were cloned and characterized. They are organized into clusters of tandemly repeated units. Each repeat unit consists of a 119-bp coding region followed by a noncoding spacer region that separates it from the coding region of the next repeat unit. Our study reports novel gene variants of the 5S rRNA genes in plants. Two families of the 5S rDNA, the 0.5-kb size family and the 1-kb size family, coexist in the E. sativa genome. The 0.5-kb size family consists of the 5S rRNA genes (S4) that have coding regions similar to those of other reported plant 5S rDNA sequences, whereas the 1-kb size family consists of the 5S rRNA gene variants (S1) that exist as 1-kb BamHI tandem repeats. S1 is made up of two variant units (V1 and V2) of 5S rDNA where the BamHI site between the two units is mutated. Sequence heterogeneity among S4, V1, and V2 units exists throughout the sequence and is not limited to the noncoding spacer region only. The coding regions of V1 and V2 show approximately 20% dissimilarity to the coding regions of S4 and other reported plant 5S rDNA sequences. Such a large variation in the coding regions of the 5S rDNA units within the same plant species has been observed for the first time. Restriction site variation is observed between the two size classes of 5S rDNA in E. sativa.(ABSTRACT TRUNCATED AT 250 WORDS)

Recommendations for Adopting the International Code of Marketing of Breast-milk Substitutes Into U.S. Policy.

PubMed

Soldavini, Jessica; Taillie, Lindsey Smith

2017-08-01

In 1981, the World Health Organization adopted the International Code of Marketing of Breast-milk Substitutes ( International Code), with subsequent resolutions adopted since then. The International Code contributes to the safe and adequate provision of nutrition for infants by protecting and promoting breastfeeding and ensuring that human milk substitutes, when necessary, are used properly through adequate information and appropriate marketing and distribution. Despite the World Health Organization recommendations for all member nations to implement the International Code in its entirety, the United States has yet to take action to translate it into any national measures. In 2012, only 22.3% of infants in the United States met the American Academy of Pediatrics recommendation of at least 6 months of exclusive breastfeeding. Countries adopting legislation reflecting the provisions of the International Code have seen increases in breastfeeding rates. This article discusses recommendations for translating the International Code into U.S. policy. Adopting legislation that implements, monitors, and enforces the International Code in its entirety has the potential to contribute to increased rates of breastfeeding in the United States, which can lead to improved health outcomes in both infants and breastfeeding mothers.

Ecosystem services impacts associated with environmental ...

EPA Pesticide Factsheets

Nitrogen release to the environment from human activities can have important and costly impacts on human health, recreation, transportation, fisheries, and ecosystem health. Recent efforts to quantify these damage costs have identified annual damages associated with reactive nitrogen release to the EU and US in the hundreds of billions of US dollars (USD). The general approach used to estimate these damages associated with reactive nitrogen are derived from a variety of methods to estimate economic damages, for example, impacts to human respiratory health in terms of hospital visits and mortality, willingness to pay to improve a water body and costs to replace or treat drinking water systems affected by nitrate or cyanotoxin contamination. These values are then extrapolated to other areas to develop the damage cost estimates that are probably best seen as potential damage costs, particularly for aquatic ecosystems. We seek to provide an additional verification of these potential damages using data assembled by the US EPA for case studies of measured costs of nutrient impacts across the US from 2000-2012. We compare the spatial distribution and the magnitude of these costs with the spatial distribution and magnitude of costs from HUC8 watershed units across the US by Sobota et al. (2015). We anticipate that this analysis will provide a ground truthing of existing damage cost estimates, and continue to support the incorporation of cost and benefit informatio

EnviroAtlas - Biodiversity Metrics by 12-digit HUC for the Southwestern United States

EPA Pesticide Factsheets

This EnviroAtlas dataset was produced by a joint effort of New Mexico State University, US EPA, and the US Geological Survey (USGS) to support research and online mapping activities related to EnviroAtlas. Ecosystem services, i.e., services provided to humans from ecological systems, have become a key issue of this century in resource management, conservation planning, and environmental decision analysis. Mapping and quantifying ecosystem services have become strategic national interests for integrating ecology with economics to help understand the effects of human policies and actions and their subsequent impacts on both ecosystem function and human well-being. Some aspects of biodiversity are valued by humans in varied ways, and thus are important to include in any assessment that seeks to identify and quantify the benefits of ecosystems to humans. Some biodiversity metrics clearly reflect ecosystem services (e.g., abundance and diversity of harvestable species), whereas others may reflect indirect and difficult to quantify relationships to services (e.g., relevance of species diversity to ecosystem resilience, or cultural and aesthetic values). Wildlife habitat has been modeled at broad spatial scales and can be used to map a number of biodiversity metrics. We map 15 biodiversity metrics reflecting ecosystem services or other aspects of biodiversity for all vertebrate species except fish. Metrics include species richness for all vertebrates, specific taxon gr

EnviroAtlas - Bird National Biodiversity Ecosystem Services Metrics by 12-digit HUC for the Conterminous United States

EPA Pesticide Factsheets

This dataset was produced by a joint effort of New Mexico State University (NMSU), the U.S. Environmental Protection Agency (EPA), and the U.S. Geological Survey (USGS) to support research and online mapping activities related to EnviroAtlas. Ecosystem services, i.e., services provided to humans from ecological systems, have become a key issue of this century in resource management, conservation planning, and environmental decision analysis. Mapping and quantifying ecosystem services have become strategic national interests for integrating ecology with economics to help understand the effects of human policies and actions and their subsequent impacts on both ecosystem function and human well-being. Some aspects of biodiversity are valued by humans in varied ways, and thus are important to include in any assessment that seeks to identify and quantify the benefits of ecosystems to humans. Some biodiversity metrics clearly reflect ecosystem services (e.g., abundance and diversity of harvestable species), whereas others may reflect indirect and difficult to quantify relationships to services (e.g., relevance of species diversity to ecosystem resilience, or cultural and aesthetic values). Wildlife habitat has been modeled at broad spatial scales and can be used to map a number of biodiversity metrics. We map 15 biodiversity metrics reflecting ecosystem services or other aspects of biodiversity for bird species. Metrics include all bird species richness, lists identif

EnviroAtlas - Biodiversity Metrics by 12-digit HUC for the Southeastern United States

EPA Pesticide Factsheets

This EnviroAtlas dataset was produced by a joint effort of New Mexico State University, US EPA, and the US Geological Survey (USGS) to support research and online mapping activities related to EnviroAtlas. Ecosystem services, i.e., services provided to humans from ecological systems, have become a key issue of this century in resource management, conservation planning, and environmental decision analysis. Mapping and quantifying ecosystem services have become strategic national interests for integrating ecology with economics to help understand the effects of human policies and actions and their subsequent impacts on both ecosystem function and human well-being. Some aspects of biodiversity are valued by humans in varied ways, and thus are important to include in any assessment that seeks to identify and quantify the benefits of ecosystems to humans. Some biodiversity metrics clearly reflect ecosystem services (e.g., abundance and diversity of harvestable species), whereas others may reflect indirect and difficult to quantify relationships to services (e.g., relevance of species diversity to ecosystem resilience, or cultural and aesthetic values). Wildlife habitat has been modeled at broad spatial scales and can be used to map a number of biodiversity metrics. We map 14 biodiversity metrics reflecting ecosystem services or other aspects of biodiversity for all vertebrate species except fish. Metrics include species richness for all vertebrates, specific taxon gr

EnviroAtlas - Total reptile species by 12-digit HUC for the conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset was produced by a joint effort of New Mexico State University, US Environmental Protection Agency (US EPA,) and the U.S. Geological Survey (USGS) to support research and online mapping activities related to EnviroAtlas. Ecosystem services, i.e., services provided to humans from ecological systems have become a key issue of this century in resource management, conservation planning, and environmental decision analysis. Mapping and quantifying ecosystem services have become strategic national interests for integrating ecology with economics to help understand the effects of human policies and actions and their subsequent impacts on both ecosystem function and human well-being. Some aspects of biodiversity are valued by humans in varied ways, and thus are important to include in any assessment that seeks to identify and quantify the benefits of ecosystems to humans. Some biodiversity metrics clearly reflect ecosystem services (e.g., abundance and diversity of harvestable species), whereas others may reflect indirect and difficult to quantify relationships to services (e.g., relevance of species diversity to ecosystem resilience, cultural and aesthetic values). Wildlife habitat has been modeled at broad spatial scales and can be used to map a number of biodiversity metrics. We map 15 biodiversity metrics reflecting ecosystem services or other aspects of biodiversity for all vertebrate species except fish. Metrics include species richness fo

Quantifying the physical demands of collision sports: does microsensor technology measure what it claims to measure?

PubMed

Gabbett, Tim J

2013-08-01

The physical demands of rugby league, rugby union, and American football are significantly increased through the large number of collisions players are required to perform during match play. Because of the labor-intensive nature of coding collisions from video recordings, manufacturers of wearable microsensor (e.g., global positioning system [GPS]) units have refined the technology to automatically detect collisions, with several sport scientists attempting to use these microsensors to quantify the physical demands of collision sports. However, a question remains over the validity of these microtechnology units to quantify the contact demands of collision sports. Indeed, recent evidence has shown significant differences in the number of "impacts" recorded by microtechnology units (GPSports) and the actual number of collisions coded from video. However, a separate study investigated the validity of a different microtechnology unit (minimaxX; Catapult Sports) that included GPS and triaxial accelerometers, and also a gyroscope and magnetometer, to quantify collisions. Collisions detected by the minimaxX unit were compared with video-based coding of the actual events. No significant differences were detected in the number of mild, moderate, and heavy collisions detected via the minimaxX units and those coded from video recordings of the actual event. Furthermore, a strong correlation (r = 0.96, p < 0.01) was observed between collisions recorded via the minimaxX units and those coded from video recordings of the event. These findings demonstrate that only one commercially available and wearable microtechnology unit (minimaxX) can be considered capable of offering a valid method of quantifying the contact loads that typically occur in collision sports. Until such validation research is completed, sport scientists should be circumspect of the ability of other units to perform similar functions.

Information theoretic analysis of proprioceptive encoding during finger flexion in the monkey sensorimotor system.

PubMed

Witham, Claire L; Baker, Stuart N

2015-01-01

There is considerable debate over whether the brain codes information using neural firing rate or the fine-grained structure of spike timing. We investigated this issue in spike discharge recorded from single units in the sensorimotor cortex, deep cerebellar nuclei, and dorsal root ganglia in macaque monkeys trained to perform a finger flexion task. The task required flexion to four different displacements against two opposing torques; the eight possible conditions were randomly interleaved. We used information theory to assess coding of task condition in spike rate, discharge irregularity, and spectral power in the 15- to 25-Hz band during the period of steady holding. All three measures coded task information in all areas tested. Information coding was most often independent between irregularity and 15-25 Hz power (60% of units), moderately redundant between spike rate and irregularity (56% of units redundant), and highly redundant between spike rate and power (93%). Most simultaneously recorded unit pairs coded using the same measure independently (86%). Knowledge of two measures often provided extra information about task, compared with knowledge of only one alone. We conclude that sensorimotor systems use both rate and temporal codes to represent information about a finger movement task. As well as offering insights into neural coding, this work suggests that incorporating spike irregularity into algorithms used for brain-machine interfaces could improve decoding accuracy. Copyright © 2015 the American Physiological Society.

Unitals and ovals of symmetric block designs in LDPC and space-time coding

NASA Astrophysics Data System (ADS)

Andriamanalimanana, Bruno R.

2004-08-01

An approach to the design of LDPC (low density parity check) error-correction and space-time modulation codes involves starting with known mathematical and combinatorial structures, and deriving code properties from structure properties. This paper reports on an investigation of unital and oval configurations within generic symmetric combinatorial designs, not just classical projective planes, as the underlying structure for classes of space-time LDPC outer codes. Of particular interest are the encoding and iterative (sum-product) decoding gains that these codes may provide. Various small-length cases have been numerically implemented in Java and Matlab for a number of channel models.

Of Codes and Crowns: The Development of Law. [Student's Book] Law-in-Social Studies Series.

ERIC Educational Resources Information Center

Suter, Coral; Croddy, Marshall

Intended to supplement secondary level world history courses, this booklet will help students understand the history of and need for rules and laws. There are five units. In the first unit, students examine evidence from anthropology and archaeology which show how rules developed in prehistoric cultures. The second unit deals with the Code of…

Automated collection and processing of environmental samples

DOEpatents

Troyer, Gary L.; McNeece, Susan G.; Brayton, Darryl D.; Panesar, Amardip K.

1997-01-01

For monitoring an environmental parameter such as the level of nuclear radiation, at distributed sites, bar coded sample collectors are deployed and their codes are read using a portable data entry unit that also records the time of deployment. The time and collector identity are cross referenced in memory in the portable unit. Similarly, when later recovering the collector for testing, the code is again read and the time of collection is stored as indexed to the sample collector, or to a further bar code, for example as provided on a container for the sample. The identity of the operator can also be encoded and stored. After deploying and/or recovering the sample collectors, the data is transmitted to a base processor. The samples are tested, preferably using a test unit coupled to the base processor, and again the time is recorded. The base processor computes the level of radiation at the site during exposure of the sample collector, using the detected radiation level of the sample, the delay between recovery and testing, the duration of exposure and the half life of the isotopes collected. In one embodiment, an identity code and a site code are optically read by an image grabber coupled to the portable data entry unit.

Size principle and information theory.

PubMed

Senn, W; Wyler, K; Clamann, H P; Kleinle, J; Lüscher, H R; Müller, L

1997-01-01

The motor units of a skeletal muscle may be recruited according to different strategies. From all possible recruitment strategies nature selected the simplest one: in most actions of vertebrate skeletal muscles the recruitment of its motor units is by increasing size. This so-called size principle permits a high precision in muscle force generation since small muscle forces are produced exclusively by small motor units. Larger motor units are activated only if the total muscle force has already reached certain critical levels. We show that this recruitment by size is not only optimal in precision but also optimal in an information theoretical sense. We consider the motoneuron pool as an encoder generating a parallel binary code from a common input to that pool. The generated motoneuron code is sent down through the motoneuron axons to the muscle. We establish that an optimization of this motoneuron code with respect to its information content is equivalent to the recruitment of motor units by size. Moreover, maximal information content of the motoneuron code is equivalent to a minimal expected error in muscle force generation.

Effect of bar-code technology on the safety of medication administration.

PubMed

Poon, Eric G; Keohane, Carol A; Yoon, Catherine S; Ditmore, Matthew; Bane, Anne; Levtzion-Korach, Osnat; Moniz, Thomas; Rothschild, Jeffrey M; Kachalia, Allen B; Hayes, Judy; Churchill, William W; Lipsitz, Stuart; Whittemore, Anthony D; Bates, David W; Gandhi, Tejal K

2010-05-06

Serious medication errors are common in hospitals and often occur during order transcription or administration of medication. To help prevent such errors, technology has been developed to verify medications by incorporating bar-code verification technology within an electronic medication-administration system (bar-code eMAR). We conducted a before-and-after, quasi-experimental study in an academic medical center that was implementing the bar-code eMAR. We assessed rates of errors in order transcription and medication administration on units before and after implementation of the bar-code eMAR. Errors that involved early or late administration of medications were classified as timing errors and all others as nontiming errors. Two clinicians reviewed the errors to determine their potential to harm patients and classified those that could be harmful as potential adverse drug events. We observed 14,041 medication administrations and reviewed 3082 order transcriptions. Observers noted 776 nontiming errors in medication administration on units that did not use the bar-code eMAR (an 11.5% error rate) versus 495 such errors on units that did use it (a 6.8% error rate)--a 41.4% relative reduction in errors (P<0.001). The rate of potential adverse drug events (other than those associated with timing errors) fell from 3.1% without the use of the bar-code eMAR to 1.6% with its use, representing a 50.8% relative reduction (P<0.001). The rate of timing errors in medication administration fell by 27.3% (P<0.001), but the rate of potential adverse drug events associated with timing errors did not change significantly. Transcription errors occurred at a rate of 6.1% on units that did not use the bar-code eMAR but were completely eliminated on units that did use it. Use of the bar-code eMAR substantially reduced the rate of errors in order transcription and in medication administration as well as potential adverse drug events, although it did not eliminate such errors. Our data show that the bar-code eMAR is an important intervention to improve medication safety. (ClinicalTrials.gov number, NCT00243373.) 2010 Massachusetts Medical Society

78 FR 37923 - Delegation of Reporting Functions Specified in Section 491 of Title 10, United State Code

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-24

...--Delegation of Reporting Functions Specified in Section 491 of Title 10, United States Code Notice of June 20..., June 24, 2013 / Presidential Documents#0;#0; #0; #0;Title 3-- #0;The President [[Page 37923

78 FR 37921 - Delegation of Reporting Functions Specified in Section 491 of Title 10, United State Code

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-24

...--Delegation of Reporting Functions Specified in Section 491 of Title 10, United States Code Notice of June 20..., June 24, 2013 / Presidential Documents#0;#0; #0; #0;Title 3-- #0;The President [[Page 37923

Accuracy and time requirements of a bar-code inventory system for medical supplies.

PubMed

Hanson, L B; Weinswig, M H; De Muth, J E

1988-02-01

The effects of implementing a bar-code system for issuing medical supplies to nursing units at a university teaching hospital were evaluated. Data on the time required to issue medical supplies to three nursing units at a 480-bed, tertiary-care teaching hospital were collected (1) before the bar-code system was implemented (i.e., when the manual system was in use), (2) one month after implementation, and (3) four months after implementation. At the same times, the accuracy of the central supply perpetual inventory was monitored using 15 selected items. One-way analysis of variance tests were done to determine any significant differences between the bar-code and manual systems. Using the bar-code system took longer than using the manual system because of a significant difference in the time required for order entry into the computer. Multiple-use requirements of the central supply computer system made entering bar-code data a much slower process. There was, however, a significant improvement in the accuracy of the perpetual inventory. Using the bar-code system for issuing medical supplies to the nursing units takes longer than using the manual system. However, the accuracy of the perpetual inventory was significantly improved with the implementation of the bar-code system.

Clean Energy in City Codes: A Baseline Analysis of Municipal Codification across the United States

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, Jeffrey J.; Aznar, Alexandra; Dane, Alexander

Municipal governments in the United States are well positioned to influence clean energy (energy efficiency and alternative energy) and transportation technology and strategy implementation within their jurisdictions through planning, programs, and codification. Municipal governments are leveraging planning processes and programs to shape their energy futures. There is limited understanding in the literature related to codification, the primary way that municipal governments enact enforceable policies. The authors fill the gap in the literature by documenting the status of municipal codification of clean energy and transportation across the United States. More directly, we leverage online databases of municipal codes to develop nationalmore » and state-specific representative samples of municipal governments by population size. Our analysis finds that municipal governments with the authority to set residential building energy codes within their jurisdictions frequently do so. In some cases, communities set codes higher than their respective state governments. Examination of codes across the nation indicates that municipal governments are employing their code as a policy mechanism to address clean energy and transportation.« less

Internationalizing professional codes in engineering.

PubMed

Harris, Charles E

2004-07-01

Professional engineering societies which are based in the United States, such as the American Society of Mechanical Engineers (ASME, now ASME International) are recognizing that their codes of ethics must apply to engineers working throughout the world. An examination of the ethical code of the ASME International shows that its provisions pose many problems of application, especially in societies outside the United States. In applying the codes effectively in the international environment, two principal issues must be addressed. First, some Culture Transcending Guidelines must be identified and justified. Nine such guidelines are identified Second, some methods for applying the codes to particular situations must be identified Three such methods are specification, balancing, and finding a creative middle way.

1 CFR 21.52 - Statutory material.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Statutory material. 21.52 Section 21.52 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF... material. (a) United States Code. All citations to statutory authority shall include a United States Code...

1 CFR 21.52 - Statutory material.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Statutory material. 21.52 Section 21.52 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF... material. (a) United States Code. All citations to statutory authority shall include a United States Code...

1 CFR 21.52 - Statutory material.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 1 General Provisions 1 2012-01-01 2012-01-01 false Statutory material. 21.52 Section 21.52 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF... material. (a) United States Code. All citations to statutory authority shall include a United States Code...

Novel Role of MDA-9/Syntenin in Regulating Urothelial Cell Proliferation by Modulating EGFR Signaling

PubMed Central

Dasgupta, Santanu; Menezes, Mitchell E.; Das, Swadesh K.; Emdad, Luni; Janjic, Aleksandar; Bhatia, Shilpa; Mukhopadhyay, Nitai D; Shao, Chunbo; Sarkar, Devanand; Fisher, Paul B.

2013-01-01

Purpose Urothelial cell carcinoma (UCC) rapidly progresses from superficial to muscle-invasive tumors. The key molecules involved in metastatic progression and its early detection require clarification. The present study defines a seminal role of the metastasis-associated gene MDA-9/Syntenin in UCC progression. Experimental Design Expression pattern of MDA-9/Syntenin was examined in 44 primary UCC and the impact of its overexpression and knock down was examined in multiple cells lines and key findings were validated in primary tumors. Results Significantly higher (p= 0.002–0.003) expression of MDA-9/Syntenin was observed in 64% (28/44) of primary tumors and an association was evident with stage (p=0.01), grade (p=0.03) and invasion status (p=0.02). MDA-9/Syntenin overexpression in non-tumorigenic HUC-1 cells increased proliferation (p=0.0012), invasion (p=0.0001) and EGFR, AKT, PI3K and c-Src expression. Alteration of Beta-catenin, E-Cadherin, Vimentin, Claudin-1, ZO-1 and TCF4 expression were also observed. MDA-9/Syntenin knock down in 3 UCC cell lines reversed phenotypic and molecular changes observed in the HUC-1 cells and reduced in vivo metastasis. Key molecular changes observed in the cell lines were confirmed in primary tumors. A physical interaction and co-localization of MDA-9/Syntenin and EGFR was evident in UCC cell lines and primary tumors. A logistic regression model analysis revealed a significant correlation between MDA-9/Syntenin:EGFR and MDA-9/Syntenin: AKT expressions with stage (p=0.04, EGFR), (p=0.01, AKT). A correlation between MDA-9/Syntenin: β-catenin co-expression with stage (p=0.03) and invasion (p=0.04) was also evident. Conclusions Our findings indicate that MDA-9/Syntenin might provide an attractive target for developing detection, monitoring and therapeutic strategies for managing UCC. PMID:23873690

Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling.

PubMed

Dasgupta, Santanu; Menezes, Mitchell E; Das, Swadesh K; Emdad, Luni; Janjic, Aleksandar; Bhatia, Shilpa; Mukhopadhyay, Nitai D; Shao, Chunbo; Sarkar, Devanand; Fisher, Paul B

2013-09-01

Urothelial cell carcinoma (UCC) rapidly progresses from superficial to muscle-invasive tumors. The key molecules involved in metastatic progression and its early detection require clarification. The present study defines a seminal role of the metastasis-associated gene MDA-9/Syntenin in UCC progression. Expression pattern of MDA-9/Syntenin was examined in 44 primary UCC and the impact of its overexpression and knockdown was examined in multiple cells lines and key findings were validated in primary tumors. Significantly higher (P=0.002-0.003) expression of MDA-9/Syntenin was observed in 64% (28 of 44) of primary tumors and an association was evident with stage (P=0.01), grade (P=0.03), and invasion status (P=0.02). MDA-9/Syntenin overexpression in nontumorigenic HUC-1 cells increased proliferation (P=0.0012), invasion (P=0.0001), and EGF receptor (EGFR), AKT, phosphoinositide 3-kinase (PI3K), and c-Src expression. Alteration of β-catenin, E-cadherin, vimentin, claudin-1, ZO-1, and T-cell factor-4 (TCF4) expression was also observed. MDA-9/Syntenin knockdown in three UCC cell lines reversed phenotypic and molecular changes observed in the HUC-1 cells and reduced in vivo metastasis. Key molecular changes observed in the cell lines were confirmed in primary tumors. A physical interaction and colocalization of MDA-9/Syntenin and EGFR was evident in UCC cell lines and primary tumors. A logistic regression model analysis revealed a significant correlation between MDA-9/Syntenin:EGFR and MDA-9/Syntenin:AKT expressions with stage (P=0.04, EGFR; P=0.01, AKT). A correlation between MDA-9/Syntenin:β-catenin coexpression with stage (P=0.03) and invasion (P=0.04) was also evident. Our findings indicate that MDA-9/Syntenin might provide an attractive target for developing detection, monitoring, and therapeutic strategies for managing UCC. ©2013 AACR.

EAC: A program for the error analysis of STAGS results for plates

NASA Technical Reports Server (NTRS)

Sistla, Rajaram; Thurston, Gaylen A.; Bains, Nancy Jane C.

1989-01-01

A computer code is now available for estimating the error in results from the STAGS finite element code for a shell unit consisting of a rectangular orthotropic plate. This memorandum contains basic information about the computer code EAC (Error Analysis and Correction) and describes the connection between the input data for the STAGS shell units and the input data necessary to run the error analysis code. The STAGS code returns a set of nodal displacements and a discrete set of stress resultants; the EAC code returns a continuous solution for displacements and stress resultants. The continuous solution is defined by a set of generalized coordinates computed in EAC. The theory and the assumptions that determine the continuous solution are also outlined in this memorandum. An example of application of the code is presented and instructions on its usage on the Cyber and the VAX machines have been provided.

76 FR 44977 - Shipping Coordinating Committee; Notice of Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-27

... packing of cargo transport units. --Consideration for the efficacy of Container Inspection Programme... Dangerous Goods, Solid Cargoes and Containers (DSC 16) to be held at IMO Headquarters, London, United... Solid Bulk Cargoes Code (IMSBC Code) including evaluation of properties of solid bulk cargos. --Casualty...

3 CFR 13552 - Executive Order 13552 of August 31, 2010. 2010 Amendments to the Manual for Courts-Martial...

Code of Federal Regulations, 2011 CFR

2011-01-01

... States of America, including chapter 47 of title 10, United States Code (Uniform Code of Military Justice, 10 U.S.C. 801-946), and in order to prescribe amendments to the Manual for Courts-Martial, United...

5 CFR 752.606 - Agency records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... title 38, United States Code; and (6) An employee of the Government Printing Office. (c) Exclusions... title 38, United States Code; and (9) An employee of the Government Printing Office. (d) Employees... employee of the Central Intelligence Agency or the Government Accountability Office; (8) An employee of the...

Further Developments in the Communication Link and Error Analysis (CLEAN) Simulator

NASA Technical Reports Server (NTRS)

Ebel, William J.; Ingels, Frank M.

1995-01-01

During the period 1 July 1993 - 30 June 1994, significant developments to the Communication Link and Error ANalysis (CLEAN) simulator were completed. Many of these were reported in the Semi-Annual report dated December 1993 which has been included in this report in Appendix A. Since December 1993, a number of additional modules have been added involving Unit-Memory Convolutional codes (UMC). These are: (1) Unit-Memory Convolutional Encoder module (UMCEncd); (2) Hard decision Unit-Memory Convolutional Decoder using the Viterbi decoding algorithm (VitUMC); and (3) a number of utility modules designed to investigate the performance of LTMC's such as LTMC column distance function (UMCdc), UMC free distance function (UMCdfree), UMC row distance function (UMCdr), and UMC Transformation (UMCTrans). The study of UMC's was driven, in part, by the desire to investigate high-rate convolutional codes which are better suited as inner codes for a concatenated coding scheme. A number of high-rate LTMC's were found which are good candidates for inner codes. Besides the further developments of the simulation, a study was performed to construct a table of the best known Unit-Memory Convolutional codes. Finally, a preliminary study of the usefulness of the Periodic Convolutional Interleaver (PCI) was completed and documented in a Technical note dated March 17, 1994. This technical note has also been included in this final report.

Argument structure hierarchy system and method for facilitating analysis and decision-making processes

DOEpatents

Janssen, Terry

2000-01-01

A system and method for facilitating decision-making comprising a computer program causing linkage of data representing a plurality of argument structure units into a hierarchical argument structure. Each argument structure unit comprises data corresponding to a hypothesis and its corresponding counter-hypothesis, data corresponding to grounds that provide a basis for inference of the hypothesis or its corresponding counter-hypothesis, data corresponding to a warrant linking the grounds to the hypothesis or its corresponding counter-hypothesis, and data corresponding to backing that certifies the warrant. The hierarchical argument structure comprises a top level argument structure unit and a plurality of subordinate level argument structure units. Each of the plurality of subordinate argument structure units comprises at least a portion of the grounds of the argument structure unit to which it is subordinate. Program code located on each of a plurality of remote computers accepts input from one of a plurality of contributors. Each input comprises data corresponding to an argument structure unit in the hierarchical argument structure and supports the hypothesis or its corresponding counter-hypothesis. A second programming code is adapted to combine the inputs into a single hierarchical argument structure. A third computer program code is responsive to the second computer program code and is adapted to represent a degree of support for the hypothesis and its corresponding counter-hypothesis in the single hierarchical argument structure.

23 CFR 710.201 - State responsibilities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false State responsibilities. 710.201 Section 710.201 Highways... interest acquired for all Federal-aid projects funded pursuant to title 23 of the United States Code shall... or acquisitions advanced under title 23 of the United States Code with a written description of its...

75 FR 53019 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... soliciting comments concerning an existing regulation, REG-147144-06, (TD 9446) Section 1.367(a)-8, Gain...: Gain Recognition Agreements With Respect to Certain Transfers of Stock or Securities by United States... Internal Revenue Code (Code) concerning gain recognition agreements filed by United States persons with...

Pacific Northwest (PNW) Hydrologic Landscape (HL) polygons and HL code

EPA Pesticide Factsheets

A five-letter hydrologic landscape code representing five indices of hydrologic form that are related to hydrologic function: climate, seasonality, aquifer permeability, terrain, and soil permeability. Each hydrologic assessment unit is classified by one of the 81 different five-letter codes representing these indices. Polygon features in this dataset were created by aggregating (dissolving boundaries between) adjacent, similarly-coded hydrologic assessment units. Climate Classes: V-Very wet, W-Wet, M-Moist, D-Dry, S-Semiarid, A-Arid. Seasonality Sub-Classes: w-Fall or winter, s-Spring. Aquifer Permeability Classes: H-High, L-Low. Terrain Classes: M-Mountain, T-Transitional, F-Flat. Soil Permeability Classes: H-High, L-Low.

Kim Jong IL and North Korea: The Leader and the System

DTIC Science & Technology

2006-03-01

defined in Title 17, United States Code , section 101. As such, it is in the public domain, and under the provisions of Title 17, United States Code ...diplomat.35 Kim probably also had a major hand in designing the massive Nuremburg -style rally at the stadium that Albright witnessed the day before

76 FR 78874 - Defense Federal Acquisition Regulation Supplement: Title 41 Positive Law Codification-Further...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-20

... Regulation Supplement: Title 41 Positive Law Codification--Further Implementation (DFARS Case 2012- D003... statutory titles to the new Positive Law Codification of Title 41, United States Code, ``Public Contracts... 111-350 enacted a new codified version of Title 41 United States Code (U.S.C.), entitled ``Public...

Factors Affecting Code Status in a University Hospital Intensive Care Unit

ERIC Educational Resources Information Center

Van Scoy, Lauren Jodi; Sherman, Michael

2013-01-01

The authors collected data on diagnosis, hospital course, and end-of-life preparedness in patients who died in the intensive care unit (ICU) with "full code" status (defined as receiving cardiopulmonary resuscitation), compared with those who didn't. Differences were analyzed using binary and stepwise logistic regression. They found no…

1 CFR 5.4 - Publication not authorized.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication not authorized. 5.4 Section 5.4... Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to treaties...) Chapter 15 of title 44, United States Code, prohibits the publication in the Federal Register of comments...

1 CFR 5.4 - Publication not authorized.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication not authorized. 5.4 Section 5.4... Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to treaties...) Chapter 15 of title 44, United States Code, prohibits the publication in the Federal Register of comments...

78 FR 62411 - Delegation of Authority Under Sections 552(c)(2) and 614 of the Foreign Assistance Act of 1961...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-21

... laws of the United States of America, including section 301 of title 3, United States Code, I hereby... and the SMC without regard to any other provision of law within the purview of section 614(a)(1) of...] Billing code 3295-F4 ...

An efficient decoding for low density parity check codes

NASA Astrophysics Data System (ADS)

Zhao, Ling; Zhang, Xiaolin; Zhu, Manjie

2009-12-01

Low density parity check (LDPC) codes are a class of forward-error-correction codes. They are among the best-known codes capable of achieving low bit error rates (BER) approaching Shannon's capacity limit. Recently, LDPC codes have been adopted by the European Digital Video Broadcasting (DVB-S2) standard, and have also been proposed for the emerging IEEE 802.16 fixed and mobile broadband wireless-access standard. The consultative committee for space data system (CCSDS) has also recommended using LDPC codes in the deep space communications and near-earth communications. It is obvious that LDPC codes will be widely used in wired and wireless communication, magnetic recording, optical networking, DVB, and other fields in the near future. Efficient hardware implementation of LDPC codes is of great interest since LDPC codes are being considered for a wide range of applications. This paper presents an efficient partially parallel decoder architecture suited for quasi-cyclic (QC) LDPC codes using Belief propagation algorithm for decoding. Algorithmic transformation and architectural level optimization are incorporated to reduce the critical path. First, analyze the check matrix of LDPC code, to find out the relationship between the row weight and the column weight. And then, the sharing level of the check node updating units (CNU) and the variable node updating units (VNU) are determined according to the relationship. After that, rearrange the CNU and the VNU, and divide them into several smaller parts, with the help of some assistant logic circuit, these smaller parts can be grouped into CNU during the check node update processing and grouped into VNU during the variable node update processing. These smaller parts are called node update kernel units (NKU) and the assistant logic circuit are called node update auxiliary unit (NAU). With NAUs' help, the two steps of iteration operation are completed by NKUs, which brings in great hardware resource reduction. Meanwhile, efficient techniques have been developed to reduce the computation delay of the node processing units and to minimize hardware overhead for parallel processing. This method may be applied not only to regular LDPC codes, but also to the irregular ones. Based on the proposed architectures, a (7493, 6096) irregular QC-LDPC code decoder is described using verilog hardware design language and implemented on Altera field programmable gate array (FPGA) StratixII EP2S130. The implementation results show that over 20% of logic core size can be saved than conventional partially parallel decoder architectures without any performance degradation. If the decoding clock is 100MHz, the proposed decoder can achieve a maximum (source data) decoding throughput of 133 Mb/s at 18 iterations.

Groundwater Discharge of Legacy Nitrogen to River Networks: Linking Regional Groundwater Models to Streambed Groundwater-Surface Water Exchange and Nitrogen Processing

NASA Astrophysics Data System (ADS)

Barclay, J. R.; Helton, A. M.; Briggs, M. A.; Starn, J. J.; Hunt, A.

2017-12-01

Despite years of management, excess nitrogen (N) is a pervasive problem in many aquatic ecosystems. More than half of surface water in the United States is derived from groundwater, and widespread N contamination in aquifers from decades of watershed N inputs suggest legacy N discharging from groundwater may contribute to contemporary N pollution problems in surface waters. Legacy N loads to streams and rivers are controlled by both regional scale flow paths and fine-scale processes that drive N transformations, such as groundwater-surface water exchange across steep redox gradients that occur at stream bed interfaces. Adequately incorporating these disparate scales is a challenge, but it is essential to understanding legacy N transport and making informed management decisions. We developed a regional groundwater flow model for the Farmington River, a HUC-8 basin that drains to the Long Island Sound, a coastal estuary that suffers from elevated N loads despite decades of management, to understand broad patterns of regional transport. To evaluate and refine the regional model, we used thermal infrared imagery paired with vertical temperature profiling to estimate groundwater discharge at the streambed interface. We also analyzed discharging groundwater for multiple N species to quantify fine scale patterns of N loading and transformation via denitrification at the streambed interface. Integrating regional and local estimates of groundwater discharge of legacy N to river networks should improve our ability to predict spatiotemporal patterns of legacy N loading to and transformation within surface waters.

Ergonomic glovebox workspace layout tool and associated method of use

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roddy, Shannon Howard

The present invention provides an elongate tool that aides in the placement of objects and machinery within a glovebox, such that the objects and machinery can be safely handled by a user. The tool includes a plurality of visual markings (in English units, metric units, other units, grooves, ridges, varying widths, etc.) that indicate distance from the user within the glovebox, optionally broken into placement preference zones that are color coded, grayscale coded, or the like.

Mandating better buildings: a global review of building codes and prospects for improvement in the United States

DOE PAGES

Sun, Xiaojing; Brown, Marilyn A.; Cox, Matt; ...

2015-03-11

This paper provides a global overview of the design, implementation, and evolution of building energy codes. Reflecting alternative policy goals, building energy codes differ significantly across the United States, the European Union, and China. This review uncovers numerous innovative practices including greenhouse gas emissions caps per square meter of building space, energy performance certificates with retrofit recommendations, and inclusion of renewable energy to achieve “nearly zero-energy buildings”. These innovations motivated an assessment of an aggressive commercial building code applied to all US states, requiring both new construction and buildings with major modifications to comply with the latest version of themore » ASHRAE 90.1 Standards. Using the National Energy Modeling System (NEMS), we estimate that by 2035, such building codes in the United States could reduce energy for space heating, cooling, water heating and lighting in commercial buildings by 16%, 15%, 20% and 5%, respectively. Impacts on different fuels and building types, energy rates and bills as well as pollution emission reductions are also examined.« less

In search of the Abrams post office, Trinity County

USGS Publications Warehouse

Lanphere, Marvin A.; Irwin, William P.

1987-01-01

An understanding of earth history depends in part on stratigraphy, a division of geology in which the distinctive features of natural units or formations of layered rocks are studied and described and names are assigned to them. The procedures for describing and naming rock units in a uniform way are incorporated in documents known as stratigraphic codes. The North American Stratigraphic Code (1983) is currently used by most geologists in the United States when formation names are selected. Rock unit names consist of a geographic name, generally taken from a natural feature near the locality where the unit was first described, followed by a descriptive feature, usually the dominant rock type in the unit. Although the procedure for naming a rock unit seems straightforward, stratigraphic nomenclature can lead to confusion when the principles outlined in the stratigraphic code are ignored or incorrectly applied. This paper traces the naming of the Abrams Mica Schist, one of the major units of the northern California Klamath Mountains. It describes how uncertainty about the location of the geographic feature after which the unit was named has led to conflicting terminology. The search revealed some interesting history of the early days of mining in the Coffee Creek region of the Trinity Alps in Trinity County. 

Effects of visual cue and response assignment on spatial stimulus coding in stimulus-response compatibility.

PubMed

Nishimura, Akio; Yokosawa, Kazuhiko

2012-01-01

Tlauka and McKenna ( 2000 ) reported a reversal of the traditional stimulus-response compatibility (SRC) effect (faster responding to a stimulus presented on the same side than to one on the opposite side) when the stimulus appearing on one side of a display is a member of a superordinate unit that is largely on the opposite side. We investigated the effects of a visual cue that explicitly shows a superordinate unit, and of assignment of multiple stimuli within each superordinate unit to one response, on the SRC effect based on superordinate unit position. Three experiments revealed that stimulus-response assignment is critical, while the visual cue plays a minor role, in eliciting the SRC effect based on the superordinate unit position. Findings suggest bidirectional interaction between perception and action and simultaneous spatial stimulus coding according to multiple frames of reference, with contribution of each coding to the SRC effect flexibly varying with task situations.

Ex-Vessel Core Melt Modeling Comparison between MELTSPREAD-CORQUENCH and MELCOR 2.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R.; Farmer, Mitchell; Francis, Matthew W.

System-level code analyses by both United States and international researchers predict major core melting, bottom head failure, and corium-concrete interaction for Fukushima Daiichi Unit 1 (1F1). Although system codes such as MELCOR and MAAP are capable of capturing a wide range of accident phenomena, they currently do not contain detailed models for evaluating some ex-vessel core melt behavior. However, specialized codes containing more detailed modeling are available for melt spreading such as MELTSPREAD as well as long-term molten corium-concrete interaction (MCCI) and debris coolability such as CORQUENCH. In a preceding study, Enhanced Ex-Vessel Analysis for Fukushima Daiichi Unit 1: Meltmore » Spreading and Core-Concrete Interaction Analyses with MELTSPREAD and CORQUENCH, the MELTSPREAD-CORQUENCH codes predicted the 1F1 core melt readily cooled in contrast to predictions by MELCOR. The user community has taken notice and is in the process of updating their systems codes; specifically MAAP and MELCOR, to improve and reduce conservatism in their ex-vessel core melt models. This report investigates why the MELCOR v2.1 code, compared to the MELTSPREAD and CORQUENCH 3.03 codes, yield differing predictions of ex-vessel melt progression. To accomplish this, the differences in the treatment of the ex-vessel melt with respect to melt spreading and long-term coolability are examined. The differences in modeling approaches are summarized, and a comparison of example code predictions is provided.« less

Hydrologic unit maps

USGS Publications Warehouse

Seaber, Paul R.; Kapinos, F. Paul; Knapp, George L.

1987-01-01

A set of maps depicting approved boundaries of, and numerical codes for, river-basin units of the United States has been developed by the U.S . Geological Survey. These 'Hydrologic Unit Maps' are four-color maps that present information on drainage, culture, hydrography, and hydrologic boundaries and codes of (1) the 21 major water-resources regions and the 222 subregions designated by the U.S . Water Resources Council, (2) the 352 accounting units of the U.S. Geological Survey's National Water Data Network, and (3) the 2,149 cataloging units of the U.S . Geological Survey's 'Catalog of information on Water Data:' The maps are plotted on the Geological Survey State base-map series at a scale of 1 :500,000 and, except for Alaska, depict hydrologic unit boundaries for all drainage basins greater than 700 square miles (1,813 square kilometers). A complete list of all the hydrologic units, along with their drainage areas, their names, and the names of the States or outlying areas in which they reside, is contained in the report. These maps and associated codes provide a standardized base for use by water-resources organizations in locating, storing, retrieving, and exchanging hydrologic data, in indexing and inventorying hydrologic data and information, in cataloging water-data acquisition activities, and in a variety of other applications. Because the maps have undergone extensive review by all principal Federal, regional, and State water-resource agencies, they are widely accepted for use in planning and describing water-use and related land-use activities, and in geographically organizing hydrologic data . Examples of these uses are given in the report . The hydrologic unit codes shown on the maps have been approved as a Federal Information Processing Standard for use by the Federal establishment.

Non-US data compression and coding research. FASAC Technical Assessment Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, R.M.; Cohn, M.; Craver, L.W.

1993-11-01

This assessment of recent data compression and coding research outside the United States examines fundamental and applied work in the basic areas of signal decomposition, quantization, lossless compression, and error control, as well as application development efforts in image/video compression and speech/audio compression. Seven computer scientists and engineers who are active in development of these technologies in US academia, government, and industry carried out the assessment. Strong industrial and academic research groups in Western Europe, Israel, and the Pacific Rim are active in the worldwide search for compression algorithms that provide good tradeoffs among fidelity, bit rate, and computational complexity,more » though the theoretical roots and virtually all of the classical compression algorithms were developed in the United States. Certain areas, such as segmentation coding, model-based coding, and trellis-coded modulation, have developed earlier or in more depth outside the United States, though the United States has maintained its early lead in most areas of theory and algorithm development. Researchers abroad are active in other currently popular areas, such as quantizer design techniques based on neural networks and signal decompositions based on fractals and wavelets, but, in most cases, either similar research is or has been going on in the United States, or the work has not led to useful improvements in compression performance. Because there is a high degree of international cooperation and interaction in this field, good ideas spread rapidly across borders (both ways) through international conferences, journals, and technical exchanges. Though there have been no fundamental data compression breakthroughs in the past five years--outside or inside the United State--there have been an enormous number of significant improvements in both places in the tradeoffs among fidelity, bit rate, and computational complexity.« less

47 CFR 97.309 - RTTY and data emission codes.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false RTTY and data emission codes. 97.309 Section 97... AMATEUR RADIO SERVICE Technical Standards § 97.309 RTTY and data emission codes. (a) Where authorized by... the following specified digital codes: (1) The 5-unit, start-stop, International Telegraph Alphabet No...

Video coding for 3D-HEVC based on saliency information

NASA Astrophysics Data System (ADS)

Yu, Fang; An, Ping; Yang, Chao; You, Zhixiang; Shen, Liquan

2016-11-01

As an extension of High Efficiency Video Coding ( HEVC), 3D-HEVC has been widely researched under the impetus of the new generation coding standard in recent years. Compared with H.264/AVC, its compression efficiency is doubled while keeping the same video quality. However, its higher encoding complexity and longer encoding time are not negligible. To reduce the computational complexity and guarantee the subjective quality of virtual views, this paper presents a novel video coding method for 3D-HEVC based on the saliency informat ion which is an important part of Human Visual System (HVS). First of all, the relationship between the current coding unit and its adjacent units is used to adjust the maximum depth of each largest coding unit (LCU) and determine the SKIP mode reasonably. Then, according to the saliency informat ion of each frame image, the texture and its corresponding depth map will be divided into three regions, that is, salient area, middle area and non-salient area. Afterwards, d ifferent quantization parameters will be assigned to different regions to conduct low complexity coding. Finally, the compressed video will generate new view point videos through the renderer tool. As shown in our experiments, the proposed method saves more bit rate than other approaches and achieves up to highest 38% encoding time reduction without subjective quality loss in compression or rendering.

Firing rate modulation of human motor units in different muscles during isometric contraction with various forces.

PubMed

Seki, K; Narusawa, M

1996-05-06

To examine the factors affecting the control of human motor units, rate coding strategies of the motor units were investigated in upper limb and intrinsic hand muscles during voluntary isometric contraction of steady force levels up to 80% of maximal voluntary contraction. Numerous spike trains from single motor units were recorded from the m. first dorsal interosseous (FDI) and the m. biceps brachii (BB) of eight human subjects by means of tungsten micro-electrodes, and the mean firing rate (MFR) was calculated for each subject and inter-individual comparisons made. The MFRs of the FDI were larger than that of the BB at the higher force level, and substantial differences were not found between these muscles at the lower force level. The slope of the linear regression line of MFRs vs. exerted forces for the FDI was more than twice that for the BB. Therefore, isometric force control of the FDI depends more on the rate coding strategy. The difference in rate coding between the FDI and BB motor units may be determined by factors other than muscle fiber composition, because both muscles are known to possess a similar composition of fiber types. Possible mechanisms underlying these characteristics of rate coding strategy are considered in this report.

76 FR 58137 - Defense Federal Acquisition Regulation Supplement; Positive Law Codification of Title 41 U.S.C...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... Supplement; Positive Law Codification of Title 41 U.S.C. (DFARS Case 2011-D036) AGENCY: Defense Acquisition... DFARS to the new Codification of Title 41, United States Code, ``Public Contracts.'' DATES: Effective... of Title 41, United States Code (U.S.C.), entitled ``Public Contracts.'' The purpose of this final...

Examination of wireless technology to improve nurse communication, response time to bed alarms, and patient safety.

PubMed

Guarascio-Howard, Linda

2011-01-01

A medical-surgical unit in a southwestern United States hospital examined the results of adding wireless communication technology to assist nurses in identifying patient bed status changes and enhancing team communication. Following the addition of wireless communication, response time to patient calls and the number of nurse-initiated communications were compared to pre-wireless calls and response time sampling period. In the baseline study, nurse-initiated communications and response time to patient calls were investigated for a team nursing model (Guarascio-Howard & Malloch, 2007). At this time, technology consisted of a nurse call system and telephones located at each decentralized nurse station and health unit coordinator (HUC) station. For this follow-up study, a wireless device was given to nurses and their team members following training on device use and privacy issues. Four registered nurses (RNs) were shadowed for 8 hours (32 hours total) before and after the introduction of the wireless devices. Data were collected regarding patient room visits, number of patient calls, bed status calls, response time to calls, and the initiator of the communication episodes. Follow-up study response time to calls significantly decreased (t-test p = .03). RNs and licensed practical nurses responded to bed status calls in less than 1 minute-62% of the 37 calls. Communication results indicated a significant shift (One Proportion Z Test) in RN-initiated communications, suggesting an enhanced ability to communicate with team members and to assist in monitoring patient status. Patient falls trended downward, although not significantly (p > .05), for a 6-month period of wireless technology use compared to the same period the previous year. The addition of a wireless device has advantages in team nursing, namely increasing communication with staff members and decreasing response time to patient and bed status calls. Limitations of the study included a change in caregiver team members and issues regarding wireless device and locator badge compliance. Administrative issues that arose during this field study included bed and cable maintenance, device battery charging, and the training of new and floating team members.

Priority-based methods for reducing the impact of packet loss on HEVC encoded video streams

NASA Astrophysics Data System (ADS)

Nightingale, James; Wang, Qi; Grecos, Christos

2013-02-01

The rapid growth in the use of video streaming over IP networks has outstripped the rate at which new network infrastructure has been deployed. These bandwidth-hungry applications now comprise a significant part of all Internet traffic and present major challenges for network service providers. The situation is more acute in mobile networks where the available bandwidth is often limited. Work towards the standardisation of High Efficiency Video Coding (HEVC), the next generation video coding scheme, is currently on track for completion in 2013. HEVC offers the prospect of a 50% improvement in compression over the current H.264 Advanced Video Coding standard (H.264/AVC) for the same quality. However, there has been very little published research on HEVC streaming or the challenges of delivering HEVC streams in resource-constrained network environments. In this paper we consider the problem of adapting an HEVC encoded video stream to meet the bandwidth limitation in a mobile networks environment. Video sequences were encoded using the Test Model under Consideration (TMuC HM6) for HEVC. Network abstraction layers (NAL) units were packetized, on a one NAL unit per RTP packet basis, and transmitted over a realistic hybrid wired/wireless testbed configured with dynamically changing network path conditions and multiple independent network paths from the streamer to the client. Two different schemes for the prioritisation of RTP packets, based on the NAL units they contain, have been implemented and empirically compared using a range of video sequences, encoder configurations, bandwidths and network topologies. In the first prioritisation method the importance of an RTP packet was determined by the type of picture and the temporal switching point information carried in the NAL unit header. Packets containing parameter set NAL units and video coding layer (VCL) NAL units of the instantaneous decoder refresh (IDR) and the clean random access (CRA) pictures were given the highest priority followed by NAL units containing pictures used as reference pictures from which others can be predicted. The second method assigned a priority to each NAL unit based on the rate-distortion cost of the VCL coding units contained in the NAL unit. The sum of the rate-distortion costs of each coding unit contained in a NAL unit was used as the priority weighting. The preliminary results of extensive experiments have shown that all three schemes offered an improvement in PSNR, when comparing original and decoded received streams, over uncontrolled packet loss. Using the first method consistently delivered a significant average improvement of 0.97dB over the uncontrolled scenario while the second method provided a measurable, but less consistent, improvement across the range of testing conditions and encoder configurations.

Coordinated design of coding and modulation systems

NASA Technical Reports Server (NTRS)

Massey, J. L.; Ancheta, T.; Johannesson, R.; Lauer, G.; Lee, L.

1976-01-01

The joint optimization of the coding and modulation systems employed in telemetry systems was investigated. Emphasis was placed on formulating inner and outer coding standards used by the Goddard Spaceflight Center. Convolutional codes were found that are nearly optimum for use with Viterbi decoding in the inner coding of concatenated coding systems. A convolutional code, the unit-memory code, was discovered and is ideal for inner system usage because of its byte-oriented structure. Simulations of sequential decoding on the deep-space channel were carried out to compare directly various convolutional codes that are proposed for use in deep-space systems.

Remembering Plurals: Unit of Coding and Form of Coding during Serial Recall.

ERIC Educational Resources Information Center

Van Der Molen, Hugo; Morton, John

1979-01-01

Adult females recalled lists of six words, including some plural nouns, presented visually in sequence. A frequent error was to detach the plural from its root. This supports a morpheme-based as opposed to a unitary word code. Evidence for a primarily phonological coding of the plural morpheme was obtained. (Author/RD)

34 CFR Appendix to Part 73 - Code of Ethics for Government Service

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Code of Ethics for Government Service Appendix to Part.... Appendix to Part 73—Code of Ethics for Government Service Any person in Government service should: Put... Code of Ethics was unanimously passed by the United States Congress on June 27, 1980, and signed into...

Ethical Issues and Codes of Ethics: Views of Adult Education Practitioners in Canada and the United States.

ERIC Educational Resources Information Center

Gordon, Wanda; Sork, Thomas J.

2001-01-01

Replicating an Indiana study, 261 responses from British Columbia adult educators revealed a high degree of support for codes of ethics and identified ethical dilemmas in practice. Half currently operated under a code. Responses to whether codes should have a regulatory function were mixed. (Contains 44 references.) (SK)

34 CFR Appendix to Part 73 - Code of Ethics for Government Service

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Code of Ethics for Government Service Appendix to Part.... Appendix to Part 73—Code of Ethics for Government Service Any person in Government service should: Put... Code of Ethics was unanimously passed by the United States Congress on June 27, 1980, and signed into...

34 CFR Appendix to Part 73 - Code of Ethics for Government Service

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 1 2014-07-01 2014-07-01 false Code of Ethics for Government Service Appendix to Part.... Appendix to Part 73—Code of Ethics for Government Service Any person in Government service should: Put... Code of Ethics was unanimously passed by the United States Congress on June 27, 1980, and signed into...

34 CFR Appendix to Part 73 - Code of Ethics for Government Service

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false Code of Ethics for Government Service Appendix to Part.... Appendix to Part 73—Code of Ethics for Government Service Any person in Government service should: Put... Code of Ethics was unanimously passed by the United States Congress on June 27, 1980, and signed into...

34 CFR Appendix to Part 73 - Code of Ethics for Government Service

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false Code of Ethics for Government Service Appendix to Part.... Appendix to Part 73—Code of Ethics for Government Service Any person in Government service should: Put... Code of Ethics was unanimously passed by the United States Congress on June 27, 1980, and signed into...

77 FR 34221 - Air Quality Designations for the 2008 Ozone National Ambient Air Quality Standards for Several...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... Regulatory Review B. Paperwork Reduction Act C. Regulatory Flexibility Act D. Unfunded Mandates Reform Act E... preamble. APA Administrative Procedure Act CAA Clean Air Act CFR Code of Federal Regulations D.C. District... Authority Rule U.S. United States U.S.C. United States Code VCS Voluntary Consensus Standards VOC Volatile...

5 CFR 335.101 - Effect of position change on status and tenure.

Code of Federal Regulations, 2010 CFR

2010-01-01

... and tenure. (a) Status. A position change authorized by § 335.102 does not change the competitive... under chapter 45 of title 39, United States Code, or required by law to be filled on a permanent basis... paid under chapter 45 of title 39, United States Code, or required by law to be filled on a permanent...

5 CFR 335.101 - Effect of position change on status and tenure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... and tenure. (a) Status. A position change authorized by § 335.102 does not change the competitive... under chapter 45 of title 39, United States Code, or required by law to be filled on a permanent basis... paid under chapter 45 of title 39, United States Code, or required by law to be filled on a permanent...

32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

Code of Federal Regulations, 2010 CFR

2010-07-01

...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... Defense assistance to programs of adult education in civil defense subjects (50 United States Code App. 2281 (e), (f)). 6. Office of Civil Defense radiological instruments grants (50 United States Code App...

32 CFR Appendix A to Part 195 - Programs to Which This Part Applies

Code of Federal Regulations, 2011 CFR

2011-07-01

...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... Defense assistance to programs of adult education in civil defense subjects (50 United States Code App. 2281 (e), (f)). 6. Office of Civil Defense radiological instruments grants (50 United States Code App...

76 FR 53497 - Florida Power and Light Company; St. Lucie Plant, Units 1 and 2; Environmental Assessment and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

... Appendix G to the Code for calculating K IM factors, and instead applies FEM [finite element modeling..., Units 1 and 2 are calculated using the CE NSSS finite element modeling methods. The Need for the... Society of Mechanical Engineers (ASME) Code, Section XI, Appendix G) or determined by applying finite...

Instruction in Specialized Braille Codes, Abacus, and Tactile Graphics at Universities in the United States and Canada

ERIC Educational Resources Information Center

Rosenblum, L. Penny; Smith, Derrick

2012-01-01

Introduction: This study gathered data on methods and materials that are used to teach the Nemeth braille code, computer braille, foreign-language braille, and music braille in 26 university programs in the United States and Canada that prepare teachers of students with visual impairments. Information about instruction in the abacus and the…

75 FR 5290 - Notice of the Record of Decision for the United States Marine Corps Grow the Force at Marine...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

...) of 1969, 42 United States Code (U.S.C.) Section 4332(2)(c), the regulations of the Council on Environmental Quality (CEQ) for Implementing the Procedural Provisions of NEPA (40 Code of Federal Regulations... infrastructure construction (e.g. buildings, roads, utility lines); (2) demolition and/or upgrades to existing...

34 CFR 685.207 - Obligation to repay.

Code of Federal Regulations, 2010 CFR

2010-07-01

... title 10, United States Code and is called or ordered to active duty for a period of more than 30 days... period when called or ordered to active duty as specified in paragraph (b)(2)(ii)(A) of this section is... of title 10, United States Code and is called or ordered to active duty for a period of more than 30...

Global digital data sets of soil type, soil texture, surface slope and other properties: Documentation of archived data tape

NASA Technical Reports Server (NTRS)

Staub, B.; Rosenzweig, C.; Rind, D.

1987-01-01

The file structure and coding of four soils data sets derived from the Zobler (1986) world soil file is described. The data were digitized on a one-degree square grid. They are suitable for large-area studies such as climate research with general circulation models, as well as in forestry, agriculture, soils, and hydrology. The first file is a data set of codes for soil unit, land-ice, or water, for all the one-degree square cells on Earth. The second file is a data set of codes for texture, land-ice, or water, for the same soil units. The third file is a data set of codes for slope, land-ice, or water for the same units. The fourth file is the SOILWRLD data set, containing information on soil properties of land cells of both Matthews' and Food and Agriculture Organization (FAO) sources. The fourth file reconciles land-classification differences between the two and has missing data filled in.

Simulating the heterogeneity in braided channel belt deposits: 1. A geometric-based methodology and code

NASA Astrophysics Data System (ADS)

Ramanathan, Ramya; Guin, Arijit; Ritzi, Robert W.; Dominic, David F.; Freedman, Vicky L.; Scheibe, Timothy D.; Lunt, Ian A.

2010-04-01

A geometric-based simulation methodology was developed and incorporated into a computer code to model the hierarchical stratal architecture, and the corresponding spatial distribution of permeability, in braided channel belt deposits. The code creates digital models of these deposits as a three-dimensional cubic lattice, which can be used directly in numerical aquifer or reservoir models for fluid flow. The digital models have stratal units defined from the kilometer scale to the centimeter scale. These synthetic deposits are intended to be used as high-resolution base cases in various areas of computational research on multiscale flow and transport processes, including the testing of upscaling theories. The input parameters are primarily univariate statistics. These include the mean and variance for characteristic lengths of sedimentary unit types at each hierarchical level, and the mean and variance of log-permeability for unit types defined at only the lowest level (smallest scale) of the hierarchy. The code has been written for both serial and parallel execution. The methodology is described in part 1 of this paper. In part 2 (Guin et al., 2010), models generated by the code are presented and evaluated.

Simulating the Heterogeneity in Braided Channel Belt Deposits: Part 1. A Geometric-Based Methodology and Code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ramanathan, Ramya; Guin, Arijit; Ritzi, Robert W.

A geometric-based simulation methodology was developed and incorporated into a computer code to model the hierarchical stratal architecture, and the corresponding spatial distribution of permeability, in braided channel belt deposits. The code creates digital models of these deposits as a three-dimensional cubic lattice, which can be used directly in numerical aquifer or reservoir models for fluid flow. The digital models have stratal units defined from the km scale to the cm scale. These synthetic deposits are intended to be used as high-resolution base cases in various areas of computational research on multiscale flow and transport processes, including the testing ofmore » upscaling theories. The input parameters are primarily univariate statistics. These include the mean and variance for characteristic lengths of sedimentary unit types at each hierarchical level, and the mean and variance of log-permeability for unit types defined at only the lowest level (smallest scale) of the hierarchy. The code has been written for both serial and parallel execution. The methodology is described in Part 1 of this series. In Part 2, models generated by the code are presented and evaluated.« less

A COTS-Based Replacement Strategy for Aging Avionics Computers

DTIC Science & Technology

2001-12-01

Communication Control Unit. A COTS-Based Replacement Strategy for Aging Avionics Computers COTS Microprocessor Real Time Operating System New Native Code...Native Code Objec ts Native Code Thread Real - Time Operating System Legacy Function x Virtual Component Environment Context Switch Thunk Add-in Replace

Verification of BWR Turbine Skyshine Dose with the MCNP5 Code Based on an Experiment Made at SHIMANE Nuclear Power Station

NASA Astrophysics Data System (ADS)

Tayama, Ryuichi; Wakasugi, Kenichi; Kawanaka, Ikunori; Kadota, Yoshinobu; Murakami, Yasuhiro

We measured the skyshine dose from turbine buildings at Shimane Nuclear Power Station Unit 1 (NS-1) and Unit 2 (NS-2), and then compared it with the dose calculated with the Monte Carlo transport code MCNP5. The skyshine dose values calculated with the MCNP5 code agreed with the experimental data within a factor of 2.8, when the roof of the turbine building was precisely modeled. We concluded that our MCNP5 calculation was valid for BWR turbine skyshine dose evaluation.

40 CFR Appendix A to Subpart A of... - Tables

Code of Federal Regulations, 2011 CFR

2011-07-01

... precursor of PM2.5. Table 2a to Appendix A of Subpart A—Data Elements for Reporting on Emissions From Point Sources, Where Required by 40 CFR 51.30 Data elements Every-yearreporting Three-yearreporting (1... phone number ✓ ✓ (6) FIPS code ✓ ✓ (7) Facility ID codes ✓ ✓ (8) Unit ID code ✓ ✓ (9) Process ID code...

Children's Behavior in the Postanesthesia Care Unit: The Development of the Child Behavior Coding System-PACU (CBCS-P)

PubMed Central

Tan, Edwin T.; Martin, Sarah R.; Fortier, Michelle A.; Kain, Zeev N.

2012-01-01

Objective To develop and validate a behavioral coding measure, the Children's Behavior Coding System-PACU (CBCS-P), for children's distress and nondistress behaviors while in the postanesthesia recovery unit. Methods A multidisciplinary team examined videotapes of children in the PACU and developed a coding scheme that subsequently underwent a refinement process (CBCS-P). To examine the reliability and validity of the coding system, 121 children and their parents were videotaped during their stay in the PACU. Participants were healthy children undergoing elective, outpatient surgery and general anesthesia. The CBCS-P was utilized and objective data from medical charts (analgesic consumption and pain scores) were extracted to establish validity. Results Kappa values indicated good-to-excellent (κ's > .65) interrater reliability of the individual codes. The CBCS-P had good criterion validity when compared to children's analgesic consumption and pain scores. Conclusions The CBCS-P is a reliable, observational coding method that captures children's distress and nondistress postoperative behaviors. These findings highlight the importance of considering context in both the development and application of observational coding schemes. PMID:22167123

Model for mapping settlements

DOEpatents

Vatsavai, Ranga Raju; Graesser, Jordan B.; Bhaduri, Budhendra L.

2016-07-05

A programmable media includes a graphical processing unit in communication with a memory element. The graphical processing unit is configured to detect one or more settlement regions from a high resolution remote sensed image based on the execution of programming code. The graphical processing unit identifies one or more settlements through the execution of the programming code that executes a multi-instance learning algorithm that models portions of the high resolution remote sensed image. The identification is based on spectral bands transmitted by a satellite and on selected designations of the image patches.

Codes and standards for structural wood products and their use in the United States

Treesearch

David W. Green; Roland Hernandez

1998-01-01

The system of model building codes and voluntary product standards used in the United States for structural lumber and engineered wood products can appear complicated and confusing to those introduced to it for the first time. This paper is a discussion of the various types of structural wood products commonly used in U.S. residential and commercial construction and...

Director of Small and Disadvantaged Business Utilization

DTIC Science & Technology

1989-03-17

Small and Disadvantaged Business Utilization References: (a) Title 15, United States Code (b) Title 10, United States Code (c) DoD 5025.1-M, "Department...position of Director of Small and Disadvantaged Business Utilization (Director, SADBU) under the direction, authority, and control of the Under...Defense Agencies, and the DoD Field Activities. C. RESPONSIBILITIES The Director of Small and Disadvantaged Business Utilization shall serve as the

Determining Market Categorization of United States Zip Codes for Purposes of Army Recruiting

DTIC Science & Technology

2016-06-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited DETERMINING MARKET ...2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE DETERMINING MARKET CATEGORIZATION OF UNITED STATES ZIP CODES FOR...Army uses commercial market segmentation data to analyze markets and past accessions to assign recruiters and quotas to maximize production. We use

An Act to Amend Title 38, United States Code, to Set a Termination Date for Veterans' Educational Benefits.... Public Law 94-502, 94th Congress.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate.

The Veterans' Education and Employment Assistance Act of 1976 (Public Law 94-502) is described in this document. The act is structured to amend title 38, United States Code, to set a termination date for veterans' educational benefits, to increase vocational rehabilitation subsistence allowances, educational and training assistance allowances, and…

Rectified factor networks for biclustering of omics data.

PubMed

Clevert, Djork-Arné; Unterthiner, Thomas; Povysil, Gundula; Hochreiter, Sepp

2017-07-15

Biclustering has become a major tool for analyzing large datasets given as matrix of samples times features and has been successfully applied in life sciences and e-commerce for drug design and recommender systems, respectively. actor nalysis for cluster cquisition (FABIA), one of the most successful biclustering methods, is a generative model that represents each bicluster by two sparse membership vectors: one for the samples and one for the features. However, FABIA is restricted to about 20 code units because of the high computational complexity of computing the posterior. Furthermore, code units are sometimes insufficiently decorrelated and sample membership is difficult to determine. We propose to use the recently introduced unsupervised Deep Learning approach Rectified Factor Networks (RFNs) to overcome the drawbacks of existing biclustering methods. RFNs efficiently construct very sparse, non-linear, high-dimensional representations of the input via their posterior means. RFN learning is a generalized alternating minimization algorithm based on the posterior regularization method which enforces non-negative and normalized posterior means. Each code unit represents a bicluster, where samples for which the code unit is active belong to the bicluster and features that have activating weights to the code unit belong to the bicluster. On 400 benchmark datasets and on three gene expression datasets with known clusters, RFN outperformed 13 other biclustering methods including FABIA. On data of the 1000 Genomes Project, RFN could identify DNA segments which indicate, that interbreeding with other hominins starting already before ancestors of modern humans left Africa. https://github.com/bioinf-jku/librfn. djork-arne.clevert@bayer.com or hochreit@bioinf.jku.at. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

45 CFR 162.103 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... definitions apply: Code set means any set of codes used to encode data elements, such as tables of terms... code sets inherent to a transaction, and not related to the format of the transaction. Data elements... information in a transaction. Data set means a semantically meaningful unit of information exchanged between...

45 CFR 162.103 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... definitions apply: Code set means any set of codes used to encode data elements, such as tables of terms... code sets inherent to a transaction, and not related to the format of the transaction. Data elements... information in a transaction. Data set means a semantically meaningful unit of information exchanged between...

WINCOF-I code for prediction of fan compressor unit with water ingestion

NASA Technical Reports Server (NTRS)

Murthy, S. N. B.; Mullican, A.

1990-01-01

The PURDUE-WINCOF code, which provides a numerical method of obtaining the performance of a fan-compressor unit of a jet engine with water ingestion into the inlet, was modified to take into account: (1) the scoop factor, (2) the time required for the setting-in of a quasi-steady distribution of water, and (3) the heat and mass transfer processes over the time calculated under 2. The modified code, named WINCOF-I was utilized to obtain the performance of a fan-compressor unit of a generic jet engine. The results illustrate the manner in which quasi-equilibrium conditions become established in the machine and the redistribution of ingested water in various stages in the form of a film out of the casing wall, droplets across the span, and vapor due to mass transfer.

On the effective implementation of a boundary element code on graphics processing units unsing an out-of-core LU algorithm

DOE Office of Scientific and Technical Information (OSTI.GOV)

D'Azevedo, Ed F; Nintcheu Fata, Sylvain

2012-01-01

A collocation boundary element code for solving the three-dimensional Laplace equation, publicly available from \\url{http://www.intetec.org}, has been adapted to run on an Nvidia Tesla general purpose graphics processing unit (GPU). Global matrix assembly and LU factorization of the resulting dense matrix were performed on the GPU. Out-of-core techniques were used to solve problems larger than available GPU memory. The code achieved over eight times speedup in matrix assembly and about 56~Gflops/sec in the LU factorization using only 512~Mbytes of GPU memory. Details of the GPU implementation and comparisons with the standard sequential algorithm are included to illustrate the performance ofmore » the GPU code.« less

40 CFR Appendix A to Subpart A of... - Tables

Code of Federal Regulations, 2010 CFR

2010-07-01

... phone number ✓ ✓ (6) FIPS code ✓ ✓ (7) Facility ID codes ✓ ✓ (8) Unit ID code ✓ ✓ (9) Process ID code... for Reporting on Emissions From Nonpoint Sources and Nonroad Mobile Sources, Where Required by 40 CFR... start date ✓ ✓ (3) Inventory end date ✓ ✓ (4) Contact name ✓ ✓ (5) Contact phone number ✓ ✓ (6) FIPS...

Evaluation of IgY Antibody as a Polyspecific Coombs-Reagent.

PubMed

Calzado, Esteban Justo Gutiérrez; Heredia, Marlene Toledano; Duharte, Jeorge Fernadez; Zarnani, Amir-Hassan

2017-01-01

During the last twenty years, the extraction of specific egg yolk (IgY) antibodies from the immunized chickens has been accepted as a useful alternative to the immunization of mammals. The aim of the present study was immunizing the chickens with Human Umbilical Cord Serum (HUCS) and the extraction of specific anti-human globulins (IgG, C3b, and C3d) antibodies from egg yolk in order to obtain polyspecific Coombs reagent. The novelty of this work was the achievement of a polyclonal reagent through a very cheap alternative method in accordance with all ethical regulations required for obtaining it. Three Leghorn hens (21 weeks old) were immunized four times for a period of 66 days with 20uL of HUCS mixed with PBS/FCA or FIA each time. The extraction of IgY antibodies was performed according to the method of lipid precipitation of yolk and using water soluble fraction as the reagent material. The resulting IgY antibody was characterized by SDS-PAGE and immunoelectrophoresis and tested for the presence of hetero-agglutinins by means of direct agglutination using human erythrocytes of all blood groups treated with 0.1% papain and for indirect Coombs-test to evaluate its specificity to fractions (C3b, C3d, C4d) of human complement and human IgG, respectively. Our findings show, that, the reagent obtained contains IgY and other 3 proteins (SDS-PAGE), and reacts specifically with plasma proteins, that migrate in β and ϒ regions. In immunoelectrophoresis, in addition, there is the presence of low hetero-agglutinins levels in IgY-preparation (3 lots), and the possibility to produce high amount (more than 500 ml/egg ) of polyspecific Coombs-reagent in chickens is also discussed. IgY-preparation (3 lots), and the possibility to produce high amount (more than 500 ml/egg ) of polyspecific Coombs-reagent in chickens with the originality to achieve a polyclonal reagent through a very cheap alternative method in accordance with all ethical regulations required for obtaining it, was also discussed.

Evaluation of IgY Antibody as a Polyspecific Coombs-Reagent

PubMed Central

Calzado, Esteban Justo Gutiérrez; Heredia, Marlene Toledano; Duharte, Jeorge Fernadez; Zarnani, Amir-Hassan

2017-01-01

Background: During the last twenty years, the extraction of specific egg yolk (IgY) antibodies from the immunized chickens has been accepted as a useful alternative to the immunization of mammals. The aim of the present study was immunizing the chickens with Human Umbilical Cord Serum (HUCS) and the extraction of specific anti-human globulins (IgG, C3b, and C3d) antibodies from egg yolk in order to obtain polyspecific Coombs reagent. Methods: The novelty of this work was the achievement of a polyclonal reagent through a very cheap alternative method in accordance with all ethical regulations required for obtaining it. Three Leghorn hens (21 weeks old) were immunized four times for a period of 66 days with 20uL of HUCS mixed with PBS/FCA or FIA each time. The extraction of IgY antibodies was performed according to the method of lipid precipitation of yolk and using water soluble fraction as the reagent material. The resulting IgY antibody was characterized by SDS-PAGE and immunoelectrophoresis and tested for the presence of hetero-agglutinins by means of direct agglutination using human erythrocytes of all blood groups treated with 0.1% papain and for indirect Coombs-test to evaluate its specificity to fractions (C3b, C3d, C4d) of human complement and human IgG, respectively. Results: Our findings show, that, the reagent obtained contains IgY and other 3 proteins (SDS-PAGE), and reacts specifically with plasma proteins, that migrate in β and ϒ regions. In immunoelectrophoresis, in addition, there is the presence of low hetero-agglutinins levels in IgY-preparation (3 lots), and the possibility to produce high amount (more than 500 ml/egg) of polyspecific Coombs-reagent in chickens is also discussed. Conclusion: IgY-preparation (3 lots), and the possibility to produce high amount (more than 500 ml/egg) of polyspecific Coombs-reagent in chickens with the originality to achieve a polyclonal reagent through a very cheap alternative method in accordance with all ethical regulations required for obtaining it, was also discussed. PMID:28496948

Dual Coding of Frequency Modulation in the Ventral Cochlear Nucleus.

PubMed

Paraouty, Nihaad; Stasiak, Arkadiusz; Lorenzi, Christian; Varnet, Léo; Winter, Ian M

2018-04-25

Frequency modulation (FM) is a common acoustic feature of natural sounds and is known to play a role in robust sound source recognition. Auditory neurons show precise stimulus-synchronized discharge patterns that may be used for the representation of low-rate FM. However, it remains unclear whether this representation is based on synchronization to slow temporal envelope (ENV) cues resulting from cochlear filtering or phase locking to faster temporal fine structure (TFS) cues. To investigate the plausibility of those encoding schemes, single units of the ventral cochlear nucleus of guinea pigs of either sex were recorded in response to sine FM tones centered at the unit's best frequency (BF). The results show that, in contrast to high-BF units, for modulation depths within the receptive field, low-BF units (<4 kHz) demonstrate good phase locking to TFS. For modulation depths extending beyond the receptive field, the discharge patterns follow the ENV and fluctuate at the modulation rate. The receptive field proved to be a good predictor of the ENV responses for most primary-like and chopper units. The current in vivo data also reveal a high level of diversity in responses across unit types. TFS cues are mainly conveyed by low-frequency and primary-like units and ENV cues by chopper and onset units. The diversity of responses exhibited by cochlear nucleus neurons provides a neural basis for a dual-coding scheme of FM in the brainstem based on both ENV and TFS cues. SIGNIFICANCE STATEMENT Natural sounds, including speech, convey informative temporal modulations in frequency. Understanding how the auditory system represents those frequency modulations (FM) has important implications as robust sound source recognition depends crucially on the reception of low-rate FM cues. Here, we recorded 115 single-unit responses from the ventral cochlear nucleus in response to FM and provide the first physiological evidence of a dual-coding mechanism of FM via synchronization to temporal envelope cues and phase locking to temporal fine structure cues. We also demonstrate a diversity of neural responses with different coding specializations. These results support the dual-coding scheme proposed by psychophysicists to account for FM sensitivity in humans and provide new insights on how this might be implemented in the early stages of the auditory pathway. Copyright © 2018 the authors 0270-6474/18/384123-15$15.00/0.

Country Report on Building Energy Codes in Australia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shui, Bin; Evans, Meredydd; Somasundaram, Sriram

2009-04-02

This report is part of a series of reports on building energy efficiency codes in countries associated with the Asian Pacific Partnership (APP) - Australia, South Korea, Japan, China, India, and the United States of America (U.S.). This reports gives an overview of the development of building energy codes in Australia, including national energy policies related to building energy codes, history of building energy codes, recent national projects and activities to promote building energy codes. The report also provides a review of current building energy codes (such as building envelope, HVAC, and lighting) for commercial and residential buildings in Australia.

Profile of Prior-Service Accessions to the U.S. (United States) Navy: Fiscal Years 1973-1981.

DTIC Science & Technology

1983-04-01

ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT. TASK AREA A WORKC UNIT NUMBERS " Institute for Policy Research and Evaluation N-253...research effort aimed at enhancing Navy manpower policy. * *. . . . . . .. - Distribution List Director Technology Programs Office of Naval Research (Code...200) Arlington, VA 22217 Director Research Programs Office of Naval Research (Code 400) Arlington, VA 22217 Manpower, Personnel and Training

Error Correcting Codes I. Applications of Elementary Algebra to Information Theory. Modules and Monographs in Undergraduate Mathematics and Its Applications Project. UMAP Unit 346.

ERIC Educational Resources Information Center

Rice, Bart F.; Wilde, Carroll O.

It is noted that with the prominence of computers in today's technological society, digital communication systems have become widely used in a variety of applications. Some of the problems that arise in digital communications systems are described. This unit presents the problem of correcting errors in such systems. Error correcting codes are…

Water Quality Management Studies. Postimpoundment Study of R.E. ’Bob’ Woodruff Lake, Alabama River, Alabama.

DTIC Science & Technology

1984-08-01

8 3. Water-quality, sediment, and biological parameters, associated units, EPA STORET codes, container type, 0 preservative and methods used for...Section III.B). Water samples were collected and preserved according to * _ approved EPA (1974) or American Public Health Association (APHA) (1975...procedures. Water-quality parameters tested, associated units, EPA STORET codes, test procedures, and preservation tech- niques used throughout the

Porting a Hall MHD Code to a Graphic Processing Unit

NASA Technical Reports Server (NTRS)

Dorelli, John C.

2011-01-01

We present our experience porting a Hall MHD code to a Graphics Processing Unit (GPU). The code is a 2nd order accurate MUSCL-Hancock scheme which makes use of an HLL Riemann solver to compute numerical fluxes and second-order finite differences to compute the Hall contribution to the electric field. The divergence of the magnetic field is controlled with Dedner?s hyperbolic divergence cleaning method. Preliminary benchmark tests indicate a speedup (relative to a single Nehalem core) of 58x for a double precision calculation. We discuss scaling issues which arise when distributing work across multiple GPUs in a CPU-GPU cluster.

On the Finite Element Implementation of the Generalized Method of Cells Micromechanics Constitutive Model

NASA Technical Reports Server (NTRS)

Wilt, T. E.

1995-01-01

The Generalized Method of Cells (GMC), a micromechanics based constitutive model, is implemented into the finite element code MARC using the user subroutine HYPELA. Comparisons in terms of transverse deformation response, micro stress and strain distributions, and required CPU time are presented for GMC and finite element models of fiber/matrix unit cell. GMC is shown to provide comparable predictions of the composite behavior and requires significantly less CPU time as compared to a finite element analysis of the unit cell. Details as to the organization of the HYPELA code are provided with the actual HYPELA code included in the appendix.

System Synchronizes Recordings from Separated Video Cameras

NASA Technical Reports Server (NTRS)

Nail, William; Nail, William L.; Nail, Jasper M.; Le, Doung T.

2009-01-01

A system of electronic hardware and software for synchronizing recordings from multiple, physically separated video cameras is being developed, primarily for use in multiple-look-angle video production. The system, the time code used in the system, and the underlying method of synchronization upon which the design of the system is based are denoted generally by the term "Geo-TimeCode(TradeMark)." The system is embodied mostly in compact, lightweight, portable units (see figure) denoted video time-code units (VTUs) - one VTU for each video camera. The system is scalable in that any number of camera recordings can be synchronized. The estimated retail price per unit would be about $350 (in 2006 dollars). The need for this or another synchronization system external to video cameras arises because most video cameras do not include internal means for maintaining synchronization with other video cameras. Unlike prior video-camera-synchronization systems, this system does not depend on continuous cable or radio links between cameras (however, it does depend on occasional cable links lasting a few seconds). Also, whereas the time codes used in prior video-camera-synchronization systems typically repeat after 24 hours, the time code used in this system does not repeat for slightly more than 136 years; hence, this system is much better suited for long-term deployment of multiple cameras.

Nuclear shell model code CRUNCHER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Resler, D.A.; Grimes, S.M.

1988-05-01

A new nuclear shell model code CRUNCHER, patterned after the code VLADIMIR, has been developed. While CRUNCHER and VLADIMIR employ the techniques of an uncoupled basis and the Lanczos process, improvements in the new code allow it to handle much larger problems than the previous code and to perform them more efficiently. Tests involving a moderately sized calculation indicate that CRUNCHER running on a SUN 3/260 workstation requires approximately one-half the central processing unit (CPU) time required by VLADIMIR running on a CRAY-1 supercomputer.

Electrical generating unit inventory 1976-1986: Illinois, Indiana, Kentucky, Ohio, Pennsylvania and West Virginia

NASA Astrophysics Data System (ADS)

Jansen, S. D.

1981-09-01

The ORBES region consists of all of Kentucky, most of West Virginia, substantial parts of Illinois, Indiana, and Ohio, and southwestern Pennsylvania. The inventory lists installed electrical generating capacity in commercial service as of December 1, 1976, and scheduled capacity additions and removals between 1977 and 1986 in the six ORBES states (Illinois, Indiana, Kentucky, Ohio, Pennsylvania, and West Virginia). The following information is included for each electrical generating unit: unit ID code, company index, whether point or industrial ownership, plant name, whether inside or outside the ORBES region, FIPS county code, type of unit, size in megawatts, type of megawatt rating, status of unit, data of commercial operation, scheduled retirement date, primary fuel, alternate fuel, type of cooling, source of cooling water, and source of information.

Model My Watershed: A high-performance cloud application for public engagement, watershed modeling and conservation decision support

NASA Astrophysics Data System (ADS)

Aufdenkampe, A. K.; Tarboton, D. G.; Horsburgh, J. S.; Mayorga, E.; McFarland, M.; Robbins, A.; Haag, S.; Shokoufandeh, A.; Evans, B. M.; Arscott, D. B.

2017-12-01

The Model My Watershed Web app (https://app.wikiwatershed.org/) and the BiG-CZ Data Portal (http://portal.bigcz.org/) and are web applications that share a common codebase and a common goal to deliver high-performance discovery, visualization and analysis of geospatial data in an intuitive user interface in web browser. Model My Watershed (MMW) was designed as a decision support system for watershed conservation implementation. BiG CZ Data Portal was designed to provide context and background data for research sites. Users begin by creating an Area of Interest, via an automated watershed delineation tool, a free draw tool, selection of a predefined area such as a county or USGS Hydrological Unit (HUC), or uploading a custom polygon. Both Web apps visualize and provide summary statistics of land use, soil groups, streams, climate and other geospatial information. MMW then allows users to run a watershed model to simulate different scenarios of human impacts on stormwater runoff and water-quality. BiG CZ Data Portal allows users to search for scientific and monitoring data within the Area of Interest, which also serves as a prototype for the upcoming Monitor My Watershed web app. Both systems integrate with CUAHSI cyberinfrastructure, including visualizing observational data from CUAHSI Water Data Center and storing user data via CUAHSI HydroShare. Both systems also integrate with the new EnviroDIY Water Quality Data Portal (http://data.envirodiy.org/), a system for crowd-sourcing environmental monitoring data using open-source sensor stations (http://envirodiy.org/mayfly/) and based on the Observations Data Model v2.

RD Optimized, Adaptive, Error-Resilient Transmission of MJPEG2000-Coded Video over Multiple Time-Varying Channels

NASA Astrophysics Data System (ADS)

Bezan, Scott; Shirani, Shahram

2006-12-01

To reliably transmit video over error-prone channels, the data should be both source and channel coded. When multiple channels are available for transmission, the problem extends to that of partitioning the data across these channels. The condition of transmission channels, however, varies with time. Therefore, the error protection added to the data at one instant of time may not be optimal at the next. In this paper, we propose a method for adaptively adding error correction code in a rate-distortion (RD) optimized manner using rate-compatible punctured convolutional codes to an MJPEG2000 constant rate-coded frame of video. We perform an analysis on the rate-distortion tradeoff of each of the coding units (tiles and packets) in each frame and adapt the error correction code assigned to the unit taking into account the bandwidth and error characteristics of the channels. This method is applied to both single and multiple time-varying channel environments. We compare our method with a basic protection method in which data is either not transmitted, transmitted with no protection, or transmitted with a fixed amount of protection. Simulation results show promising performance for our proposed method.

26 CFR 1.6042-3 - Dividends subject to reporting.

Code of Federal Regulations, 2012 CFR

2012-04-01

... documentation of foreign status and definition of U.S. payor and non-U.S. payor) shall apply. The provisions of... the Internal Revenue Code (Code). (iv) Distributions or payments from sources outside the United States (as determined under the provisions of part I, subchapter N, chapter 1 of the Code and the...

Identification of ICD Codes Suggestive of Child Maltreatment

ERIC Educational Resources Information Center

Schnitzer, Patricia G.; Slusher, Paula L.; Kruse, Robin L.; Tarleton, Molly M.

2011-01-01

Objective: In order to be reimbursed for the care they provide, hospitals in the United States are required to use a standard system to code all discharge diagnoses: the International Classification of Disease, 9th Revision, Clinical Modification (ICD-9). Although ICD-9 codes specific for child maltreatment exist, they do not identify all…

48 CFR Appendix D to Chapter 7 - Direct USAID Contracts With a U.S. Citizen or a U.S. Resident Alien for Personal Services Abroad

Code of Federal Regulations, 2014 CFR

2014-10-01

... Government employees for purposes of the Internal Revenue Code (Title 26 of the United States Code) and are... of the Foreign Assistance Act of 1961, as amended, and the Internal Revenue Code (Title 26 of the...

48 CFR Appendix D to Chapter 7 - Direct USAID Contracts With a U.S. Citizen or a U.S. Resident Alien for Personal Services Abroad

Code of Federal Regulations, 2012 CFR

2012-10-01

... Government employees for purposes of the Internal Revenue Code (Title 26 of the United States Code) and are... of the Foreign Assistance Act of 1961, as amended, and the Internal Revenue Code (Title 26 of the...

48 CFR Appendix D to Chapter 7 - Direct USAID Contracts With a U.S. Citizen or a U.S. Resident Alien for Personal Services Abroad

Code of Federal Regulations, 2013 CFR

2013-10-01

... Government employees for purposes of the Internal Revenue Code (Title 26 of the United States Code) and are... of the Foreign Assistance Act of 1961, as amended, and the Internal Revenue Code (Title 26 of the...

26 CFR 1.42-5 - Monitoring compliance with low-income housing credit requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... be required to retain the original local health, safety, or building code violation reports or... account local health, safety, and building codes (or other habitability standards), and the State or local government unit responsible for making local health, safety, or building code inspections did not issue a...

Teaching Speech Organization and Outlining Using a Color-Coded Approach.

ERIC Educational Resources Information Center

Hearn, Ralene

The organization/outlining unit in the basic Public Speaking course can be made more interesting by using a color-coded instructional method that captivates students, facilitates understanding, and provides the opportunity for interesting reinforcement activities. The two part lesson includes a mini-lecture with a color-coded outline and a two…

26 CFR 1.42-5 - Monitoring compliance with low-income housing credit requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... be required to retain the original local health, safety, or building code violation reports or... account local health, safety, and building codes (or other habitability standards), and the State or local government unit responsible for making local health, safety, or building code inspections did not issue a...

Reactivity effects in VVER-1000 of the third unit of the kalinin nuclear power plant at physical start-up. Computations in ShIPR intellectual code system with library of two-group cross sections generated by UNK code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zizin, M. N.; Zimin, V. G.; Zizina, S. N., E-mail: zizin@adis.vver.kiae.ru

2010-12-15

The ShIPR intellectual code system for mathematical simulation of nuclear reactors includes a set of computing modules implementing the preparation of macro cross sections on the basis of the two-group library of neutron-physics cross sections obtained for the SKETCH-N nodal code. This library is created by using the UNK code for 3D diffusion computation of first VVER-1000 fuel loadings. Computation of neutron fields in the ShIPR system is performed using the DP3 code in the two-group diffusion approximation in 3D triangular geometry. The efficiency of all groups of control rods for the first fuel loading of the third unit ofmore » the Kalinin Nuclear Power Plant is computed. The temperature, barometric, and density effects of reactivity as well as the reactivity coefficient due to the concentration of boric acid in the reactor were computed additionally. Results of computations are compared with the experiment.« less

Reactivity effects in VVER-1000 of the third unit of the kalinin nuclear power plant at physical start-up. Computations in ShIPR intellectual code system with library of two-group cross sections generated by UNK code

NASA Astrophysics Data System (ADS)

Zizin, M. N.; Zimin, V. G.; Zizina, S. N.; Kryakvin, L. V.; Pitilimov, V. A.; Tereshonok, V. A.

2010-12-01

The ShIPR intellectual code system for mathematical simulation of nuclear reactors includes a set of computing modules implementing the preparation of macro cross sections on the basis of the two-group library of neutron-physics cross sections obtained for the SKETCH-N nodal code. This library is created by using the UNK code for 3D diffusion computation of first VVER-1000 fuel loadings. Computation of neutron fields in the ShIPR system is performed using the DP3 code in the two-group diffusion approximation in 3D triangular geometry. The efficiency of all groups of control rods for the first fuel loading of the third unit of the Kalinin Nuclear Power Plant is computed. The temperature, barometric, and density effects of reactivity as well as the reactivity coefficient due to the concentration of boric acid in the reactor were computed additionally. Results of computations are compared with the experiment.

49 CFR 602.15 - Grant requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... either State or locally adopted building codes or standards, the higher of the competing minimums would... title 49, United States Code, as well as cross-cutting requirements, including but not limited to those...

49 CFR 602.15 - Grant requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... either State or locally adopted building codes or standards, the higher of the competing minimums would... title 49, United States Code, as well as cross-cutting requirements, including but not limited to those...

NACSN, note 67--Application for revision of Articles 36 and 37, Lithodemic units of the North American stratigraphic code

USGS Publications Warehouse

Easton, Robert M.; Edwards, Lucy E.; Orndorff, Randall C.; Duguet, Manuel; Ferrusquia-Villafranca, Ismael

2015-01-01

Currently the North American Stratigraphic Code, (NACSN 2005, Article 37) sets restrictions on the use of the term “complex” for lithodemic units. With exceptions for “volcanic complex” and “structural complex,” a complex must consist of more than one genetic class of rock (i.e., sedimentary, igneous or metamorphic). Thus, the use of the term “complex” to describe masses of intrusive rocks is not allowed. Asimilar restriction is also included in a recent British Geological Survey proposal for using lithodemic units to classify igneous rocks (Gillespie et al. 2008).Currently the North American Stratigraphic Code, (NACSN 2005, Article 37) sets restrictions on the use of the term “complex” for lithodemic units. With exceptions for “volcanic complex” and “structural complex,” a complex must consist of more than one genetic class of rock (i.e., sedimentary, igneous or metamorphic). Thus, the use of the term “complex” to describe masses of intrusive rocks is not allowed. Asimilar restriction is also included in a recent British Geological Survey proposal for using lithodemic units to classify igneous rocks (Gillespie et al. 2008).

Application of Advanced Concepts and Techniques in Electromagnetic Topology Based Simulations: CRIPTE and Related Codes

DTIC Science & Technology

2008-12-01

multiconductor transmission line theory. The per-unit capacitance, inductance , and characteristic impedance matrices generated from the companion LAPLACE...code based on the Method of Moments application, by meshing different sections of the multiconductor cable for capacitance and inductance matrices [21...conductors held together in four pairs and resided in the cable jacket. Each of eight conductors was also designed with the per unit length resistance

Alcohol industry self-regulation: who is it really protecting?

PubMed

Noel, Jonathan; Lazzarini, Zita; Robaina, Katherine; Vendrame, Alan

2017-01-01

Self-regulation has been promoted by the alcohol industry as a sufficient means of regulating alcohol marketing activities. However, evidence suggests that the guidelines of self-regulated alcohol marketing codes are violated routinely, resulting in excessive alcohol marketing exposure to youth and the use of content that is potentially harmful to youth and other vulnerable populations. If the alcohol industry does not adhere to its own regulations the purpose and design of these codes should be questioned. Indeed, implementation of alcohol marketing self-regulation in Brazil, the United Kingdom and the United States was likely to delay statutory regulation rather than to promote public health. Moreover, current self-regulation codes suffer from vague language that may allow the industry to circumvent the guidelines, loopholes that may obstruct the implementation of the codes, lax exposure guidelines that can allow excessive youth exposure, even if properly followed, and a standard of review that may be inappropriate for protecting vulnerable populations. Greater public health benefits may be realized if legislative restrictions were applied to alcohol marketing, and strict statutory alcohol marketing regulations have been implemented and defended successfully in the European Union, with European courts declaring that restrictions on alcohol marketing are proportional to the benefits to public health. In contrast, attempts to restrict alcohol marketing activities in the United States have occurred through private litigation and have been unsuccessful. None the less, repeated violations of industry codes may provide legislators with sufficient justification to pass new legislation and for such legislation to withstand constitutional review in the United States and elsewhere. © 2016 Society for the Study of Addiction.

Country Report on Building Energy Codes in Canada

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shui, Bin; Evans, Meredydd

2009-04-06

This report is part of a series of reports on building energy efficiency codes in countries associated with the Asian Pacific Partnership (APP) - Australia, South Korea, Japan, China, India, and the United States of America . This reports gives an overview of the development of building energy codes in Canada, including national energy policies related to building energy codes, history of building energy codes, recent national projects and activities to promote building energy codes. The report also provides a review of current building energy codes (such as building envelope, HVAC, lighting, and water heating) for commercial and residential buildingsmore » in Canada.« less

High dynamic range coding imaging system

NASA Astrophysics Data System (ADS)

Wu, Renfan; Huang, Yifan; Hou, Guangqi

2014-10-01

We present a high dynamic range (HDR) imaging system design scheme based on coded aperture technique. This scheme can help us obtain HDR images which have extended depth of field. We adopt Sparse coding algorithm to design coded patterns. Then we utilize the sensor unit to acquire coded images under different exposure settings. With the guide of the multiple exposure parameters, a series of low dynamic range (LDR) coded images are reconstructed. We use some existing algorithms to fuse and display a HDR image by those LDR images. We build an optical simulation model and get some simulation images to verify the novel system.

Oil and gas field code master list, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This document contains data collected through October 1993 and provides standardized field name spellings and codes for all identified oil and/or gas fields in the United States. Other Federal and State government agencies, as well as industry, use the EIA Oil and Gas Field Code Master List as the standard for field identification. A machine-readable version of the Oil and Gas Field Code Master List is available from the National Technical Information Service.

[Introduction of a bar coding pharmacy stock replenishment system in a prehospital emergency medical unit: economical impact].

PubMed

Dupuis, S; Fecci, J-L; Noyer, P; Lecarpentier, E; Chollet-Xémard, C; Margenet, A; Marty, J; Combes, X

2009-01-01

To assess economical impact after introduction of a bar coding pharmacy stock replenishment system in a prehospital emergency medical unit. Observational before and after study. A computer system using specific software and bare-code technology was introduced in the pre hospital emergency medical unit (Smur). Overall activity and costs related to pharmacy were recorded annually during two periods: the first 2 years period before computer system introduction and the second one during the 4 years following this system installation. The overall clinical activity increased by 10% between the two periods whereas pharmacy related costs continuously decreased after the start of pharmacy management computer system use. Pharmacy stock management was easier after introduction of the new stock replenishment system. The mean pharmacy related cost of one patient management was 13 Euros before and 9 Euros after the introduction of the system. The overall cost savings during the studied period was calculated to reach 134,000 Euros. The introduction of a specific pharmacy management computer system allowed to do important costs savings in a prehospital emergency medical unit.

Status and Outlook of Metric Conversion of Standards: The Views of Nine Selected Major Standards Development Bodies.

DTIC Science & Technology

1982-05-01

insufficient need for a hard metric version of the ASME Boiler and Pressure Vessel Code and industry would not support the metric version. The Code Is not...aircraft industry is concerned with certification requirements in metric units. The inch-pound Boiler and Pressure Vessel Code is the current standard

Transferring Standard English Braille Skills to the Unified English Braille Code: A Pilot Study

ERIC Educational Resources Information Center

Steinman, Bernard A.; Kimbrough, B. T.; Johnson, Franklin; LeJeune, B. J.

2004-01-01

The enormously complex and sometimes controversial project to unify the traditional literary Braille code used in English-speaking countries with the technical and mathematical codes authorized by the Braille Authority of North America (BANA) and the Braille Authority of the United Kingdom (BAUK) proposes to change English Grade Two Braille on a…

Transcoding method from H.264/AVC to high efficiency video coding based on similarity of intraprediction, interprediction, and motion vector

NASA Astrophysics Data System (ADS)

Liu, Mei-Feng; Zhong, Guo-Yun; He, Xiao-Hai; Qing, Lin-Bo

2016-09-01

Currently, most video resources on line are encoded in the H.264/AVC format. More fluent video transmission can be obtained if these resources are encoded in the newest international video coding standard: high efficiency video coding (HEVC). In order to improve the video transmission and storage on line, a transcoding method from H.264/AVC to HEVC is proposed. In this transcoding algorithm, the coding information of intraprediction, interprediction, and motion vector (MV) in H.264/AVC video stream are used to accelerate the coding in HEVC. It is found through experiments that the region of interprediction in HEVC overlaps that in H.264/AVC. Therefore, the intraprediction for the region in HEVC, which is interpredicted in H.264/AVC, can be skipped to reduce coding complexity. Several macroblocks in H.264/AVC are combined into one PU in HEVC when the MV difference between two of the macroblocks in H.264/AVC is lower than a threshold. This method selects only one coding unit depth and one prediction unit (PU) mode to reduce the coding complexity. An MV interpolation method of combined PU in HEVC is proposed according to the areas and distances between the center of one macroblock in H.264/AVC and that of the PU in HEVC. The predicted MV accelerates the motion estimation for HEVC coding. The simulation results show that our proposed algorithm achieves significant coding time reduction with a little loss in bitrates distortion rate, compared to the existing transcoding algorithms and normal HEVC coding.

Exploring longitudinal shifts in international nurse migration to the United States between 2003 and 2013 through a random effects panel data analysis.

PubMed

Squires, Allison; Ojemeni, Melissa T; Jones, Simon

2016-06-30

No study has examined the longitudinal trends in National Council Licensure Exam for Registered Nurse (NCLEX-RN) applicants and pass rates among internationally-educated nurses (IENs) seeking to work in the United States, nor has any analysis explored the impact of specific events on these trends, including changes to the NCLEX-RN exam, the role of the economic crisis, or the passing of the WHO Code on the International Recruitment of Health Personnel. This study seeks to understand the impact of the three aforementioned factors that may be influencing current and future IEN recruitment patterns in the United States. In this random effects panel data analysis, we analyzed 11 years (2003-2013) of annual IEN applicant numbers and pass rates for registered nurse credentialing. Data were obtained from publicly available reports on exam pass rates. With the global economic crisis and NCLEX-RN changes in 2008 coupled with the WHO Code passage in 2010, we sought to compare if (1) the number of applicants changed significantly after those 2 years and (2) if pass rates changed following exam modifications implemented in 2008 and 2011. A total of 177 countries were eligible for inclusion in this analysis, representing findings from 200,453 IEN applicants to the United States between 2003 and 2013. The majority of applicants were from the Philippines (58 %) and India (11 %), with these two countries combined representing 69 % of the total. Candidates from Sub-Saharan African countries totalled 7133 (3 % of all applications) over the study period, with half of these coming from Nigeria alone. No significant changes were found in the number of candidates following the 2008 economic crisis or the 2010 WHO Code, although pass rates decreased significantly following the 2008 exam modifications and the WHO Code implementation. This study suggests that, while the WHO Code has had an influence on overall IEN migration dynamics to the United States by decreasing candidate numbers, in most cases, the WHO Code was not the single cause of these fluctuations. Indeed, the impact of the NCLEX-RN exam changes appears to exert a larger influence.

Operation of the Defense Acquisition System

DTIC Science & Technology

2008-12-08

United States Code (l) DoD Directive 8320.02, “Data Sharing in a Net-Centric Department of Defense,” December 2, 2004 (m) DoD Instruction 5200.39...2004 (t) ISO 15418-1999- “EAN/ UCC Application Identifiers and Fact Data Identifiers and Maintenance” (u) ISO 15434-1999 – “Transfer Syntax for High...Acquisition Knowledge Sharing System7 (y) Section 644 of title 15, United States Code, “Procurement strategies; contract bundling” (z) Public Law 101-576

31 CFR Appendix C to Part 589 - Executive Order 13662

Code of Federal Regulations, 2014 CFR

2014-07-01

... Constitution and the laws of the United States of America, including the International Emergency Economic... 3, United States Code, I, BARACK OBAMA, President of the United States of America, hereby expand the... United States. Accordingly, I hereby order: Section 1. (a) All property and interests in property that...

Coupling Legacy and Contemporary Deterministic Codes to Goldsim for Probabilistic Assessments of Potential Low-Level Waste Repository Sites

NASA Astrophysics Data System (ADS)

Mattie, P. D.; Knowlton, R. G.; Arnold, B. W.; Tien, N.; Kuo, M.

2006-12-01

Sandia National Laboratories (Sandia), a U.S. Department of Energy National Laboratory, has over 30 years experience in radioactive waste disposal and is providing assistance internationally in a number of areas relevant to the safety assessment of radioactive waste disposal systems. International technology transfer efforts are often hampered by small budgets, time schedule constraints, and a lack of experienced personnel in countries with small radioactive waste disposal programs. In an effort to surmount these difficulties, Sandia has developed a system that utilizes a combination of commercially available codes and existing legacy codes for probabilistic safety assessment modeling that facilitates the technology transfer and maximizes limited available funding. Numerous codes developed and endorsed by the United States Nuclear Regulatory Commission and codes developed and maintained by United States Department of Energy are generally available to foreign countries after addressing import/export control and copyright requirements. From a programmatic view, it is easier to utilize existing codes than to develop new codes. From an economic perspective, it is not possible for most countries with small radioactive waste disposal programs to maintain complex software, which meets the rigors of both domestic regulatory requirements and international peer review. Therefore, re-vitalization of deterministic legacy codes, as well as an adaptation of contemporary deterministic codes, provides a creditable and solid computational platform for constructing probabilistic safety assessment models. External model linkage capabilities in Goldsim and the techniques applied to facilitate this process will be presented using example applications, including Breach, Leach, and Transport-Multiple Species (BLT-MS), a U.S. NRC sponsored code simulating release and transport of contaminants from a subsurface low-level waste disposal facility used in a cooperative technology transfer project between Sandia National Laboratories and Taiwan's Institute of Nuclear Energy Research (INER) for the preliminary assessment of several candidate low-level waste repository sites. Sandia National Laboratories is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE AC04 94AL85000.

The positive financial impact of using an Intensive Care Information System in a tertiary Intensive Care Unit.

PubMed

Levesque, Eric; Hoti, Emir; de La Serna, Sofia; Habouchi, Houssam; Ichai, Philippe; Saliba, Faouzi; Samuel, Didier; Azoulay, Daniel

2013-03-01

In the French healthcare system, the intensive care budget allocated is directly dependent on the activity level of the center. To evaluate this activity level, it is necessary to code the medical diagnoses and procedures performed on Intensive Care Unit (ICU) patients. The aim of this study was to evaluate the effects of using an Intensive Care Information System (ICIS) on the incidence of coding errors and its impact on the ICU budget allocated. Since 2005, the documentation on and monitoring of every patient admitted to our ICU has been carried out using an ICIS. However, the coding process was performed manually until 2008. This study focused on two periods: the period of manual coding (year 2007) and the period of computerized coding (year 2008) which covered a total of 1403 ICU patients. The time spent on the coding process, the rate of coding errors (defined as patients missed/not coded or wrongly identified as undergoing major procedure/s) and the financial impact were evaluated for these two periods. With computerized coding, the time per admission decreased significantly (from 6.8 ± 2.8 min in 2007 to 3.6 ± 1.9 min in 2008, p<0.001). Similarly, a reduction in coding errors was observed (7.9% vs. 2.2%, p<0.001). This decrease in coding errors resulted in a reduced difference between the potential and real ICU financial supplements obtained in the respective years (€194,139 loss in 2007 vs. a €1628 loss in 2008). Using specific computer programs improves the intensive process of manual coding by shortening the time required as well as reducing errors, which in turn positively impacts the ICU budget allocation. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Scoring the Strengths and Weaknesses of Underage Drinking Laws in the United States

PubMed Central

Fell, James C.; Thomas, Sue; Scherer, Michael; Fisher, Deborah A.; Romano, Eduardo

2015-01-01

Several studies have examined the impact of a number of minimum legal drinking age 21 (MLDA-21) laws on underage alcohol consumption and alcohol-related crashes in the United States. These studies have contributed to our understanding of how alcohol control laws affect drinking and driving among those who are under age 21. However, much of the extant literature examining underage drinking laws use a “Law/No law” coding which may obscure the variability inherent in each law. Previous literature has demonstrated that inclusion of law strengths may affect outcomes and overall data fit when compared to “Law/No law” coding. In an effort to assess the relative strength of states’ underage drinking legislation, a coding system was developed in 2006 and applied to 16 MLDA-21 laws. The current article updates the previous endeavor and outlines a detailed strength coding mechanism for the current 20 MLDA-21 laws. PMID:26097775

Dynamic wavefront creation for processing units using a hybrid compactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Puthoor, Sooraj; Beckmann, Bradford M.; Yudanov, Dmitri

A method, a non-transitory computer readable medium, and a processor for repacking dynamic wavefronts during program code execution on a processing unit, each dynamic wavefront including multiple threads are presented. If a branch instruction is detected, a determination is made whether all wavefronts following a same control path in the program code have reached a compaction point, which is the branch instruction. If no branch instruction is detected in executing the program code, a determination is made whether all wavefronts following the same control path have reached a reconvergence point, which is a beginning of a program code segment tomore » be executed by both a taken branch and a not taken branch from a previous branch instruction. The dynamic wavefronts are repacked with all threads that follow the same control path, if all wavefronts following the same control path have reached the branch instruction or the reconvergence point.« less

Force Identification from Structural Response

DTIC Science & Technology

1999-12-01

STUDENT AT (If applicable) AFIT/CIA Univ of New Mexico A 6c. ADDRESS (City, State, and ZIP Code ) 7b. ADDRESS (City, State, and ZIP Code ) Wright...ADDRESS (City, State, and ZIP Code ) 10. SOURCE OF FUNDING NUMBERS PROGRAM PROJECT TASK WORK UNIT ELEMENT NO. NO. NO. ACCESSION NO. 11. TITLE (h,,clude...FOR PUBLIC RELEASE IAW AFR 190-1 ERNEST A. HAYGOOD, 1st Lt, USAF Executive Officer, Civilian Institution Programs 17. COSATI CODES 18. SUBJECT TERMS

A smooth particle hydrodynamics code to model collisions between solid, self-gravitating objects

NASA Astrophysics Data System (ADS)

Schäfer, C.; Riecker, S.; Maindl, T. I.; Speith, R.; Scherrer, S.; Kley, W.

2016-05-01

Context. Modern graphics processing units (GPUs) lead to a major increase in the performance of the computation of astrophysical simulations. Owing to the different nature of GPU architecture compared to traditional central processing units (CPUs) such as x86 architecture, existing numerical codes cannot be easily migrated to run on GPU. Here, we present a new implementation of the numerical method smooth particle hydrodynamics (SPH) using CUDA and the first astrophysical application of the new code: the collision between Ceres-sized objects. Aims: The new code allows for a tremendous increase in speed of astrophysical simulations with SPH and self-gravity at low costs for new hardware. Methods: We have implemented the SPH equations to model gas, liquids and elastic, and plastic solid bodies and added a fragmentation model for brittle materials. Self-gravity may be optionally included in the simulations and is treated by the use of a Barnes-Hut tree. Results: We find an impressive performance gain using NVIDIA consumer devices compared to our existing OpenMP code. The new code is freely available to the community upon request. If you are interested in our CUDA SPH code miluphCUDA, please write an email to Christoph Schäfer. miluphCUDA is the CUDA port of miluph. miluph is pronounced [maßl2v]. We do not support the use of the code for military purposes.

Monte Carlo calculation of dose rate conversion factors for external exposure to photon emitters in soil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clovas, A.; Zanthos, S.; Antonopoulos-Domis, M.

2000-03-01

The dose rate conversion factors {dot D}{sub CF} (absorbed dose rate in air per unit activity per unit of soil mass, nGy h{sup {minus}1} per Bq kg{sup {minus}1}) are calculated 1 m above ground for photon emitters of natural radionuclides uniformly distributed in the soil. Three Monte Carlo codes are used: (1) The MCNP code of Los Alamos; (2) The GEANT code of CERN; and (3) a Monte Carlo code developed in the Nuclear Technology Laboratory of the Aristotle University of Thessaloniki. The accuracy of the Monte Carlo results is tested by the comparison of the unscattered flux obtained bymore » the three Monte Carlo codes with an independent straightforward calculation. All codes and particularly the MCNP calculate accurately the absorbed dose rate in air due to the unscattered radiation. For the total radiation (unscattered plus scattered) the {dot D}{sub CF} values calculated from the three codes are in very good agreement between them. The comparison between these results and the results deduced previously by other authors indicates a good agreement (less than 15% of difference) for photon energies above 1,500 keV. Antithetically, the agreement is not as good (difference of 20--30%) for the low energy photons.« less

Coding tools investigation for next generation video coding based on HEVC

NASA Astrophysics Data System (ADS)

Chen, Jianle; Chen, Ying; Karczewicz, Marta; Li, Xiang; Liu, Hongbin; Zhang, Li; Zhao, Xin

2015-09-01

The new state-of-the-art video coding standard, H.265/HEVC, has been finalized in 2013 and it achieves roughly 50% bit rate saving compared to its predecessor, H.264/MPEG-4 AVC. This paper provides the evidence that there is still potential for further coding efficiency improvements. A brief overview of HEVC is firstly given in the paper. Then, our improvements on each main module of HEVC are presented. For instance, the recursive quadtree block structure is extended to support larger coding unit and transform unit. The motion information prediction scheme is improved by advanced temporal motion vector prediction, which inherits the motion information of each small block within a large block from a temporal reference picture. Cross component prediction with linear prediction model improves intra prediction and overlapped block motion compensation improves the efficiency of inter prediction. Furthermore, coding of both intra and inter prediction residual is improved by adaptive multiple transform technique. Finally, in addition to deblocking filter and SAO, adaptive loop filter is applied to further enhance the reconstructed picture quality. This paper describes above-mentioned techniques in detail and evaluates their coding performance benefits based on the common test condition during HEVC development. The simulation results show that significant performance improvement over HEVC standard can be achieved, especially for the high resolution video materials.

Color-Coded Labels Cued Nurses to Adhere to Central Line Connector Change.

PubMed

Morrison, Theresa Lynch; Laney, Christina; Foglesong, Jan; Brennaman, Laura

2016-01-01

This study examined nurses' adherence to policies regarding needleless connector changes using a novel, day-of-the-week, color-coded label compared with usual care that relied on electronic medical record (EMR) documentation. This was a prospective, comparative study. The study was performed on 4 medical-surgical units in a seasonally fluctuating, 715-bed healthcare system composed of 2 community hospitals. Convenience sample was composed of adults with central lines hospitalized for 4 or more days. At 4-day intervals, investigators observed bedside label use and EMR needleless connector change documentation. Control patients received standard care-needleless connector change with associated documentation in the EMR. Intervention patients, in addition to standard care, had a day-of-the-week, color-coded label placed on each needleless connector. To account for clustering within unit, multinomial logistic regression models using survey sampling methodology were used to conduct Wald χ tests. A multinominal odds ratio and 95% confidence interval (CI) provided an estimate of using labels that were provided on units relative to usual care documentation of needleless connector change in the EMR. In 335 central line observations, the units with labels (n = 205) had a 321% increase rate of documentation of needleless connector change in the EMR (odds ratio, 4.21; 95% CI, 1.76-10.10; P = .003) compared with the usual care control patients. For units with labels, when labels were present, placement of labels on needleless connectors increased the odds that nurses documented connector changes per policy (4.72; 95% CI, 2.02, 10.98; P = .003). Day-of-the-week, color-coded labels cued nurses to document central line needleless connector change in the EMR, which increased adherence to the needleless connector change policy. Providing day-of-the-week, color-coded needleless connector labels increased EMR documentation of timely needleless connector changes. Timely needleless connector changes may lower the incidence of central line-associated bloodstream infection.

The Effects of Bar-coding Technology on Medication Errors: A Systematic Literature Review.

PubMed

Hutton, Kevin; Ding, Qian; Wellman, Gregory

2017-02-24

The bar-coding technology adoptions have risen drastically in U.S. health systems in the past decade. However, few studies have addressed the impact of bar-coding technology with strong prospective methodologies and the research, which has been conducted from both in-pharmacy and bedside implementations. This systematic literature review is to examine the effectiveness of bar-coding technology on preventing medication errors and what types of medication errors may be prevented in the hospital setting. A systematic search of databases was performed from 1998 to December 2016. Studies measuring the effect of bar-coding technology on medication errors were included in a full-text review. Studies with the outcomes other than medication errors such as efficiency or workarounds were excluded. The outcomes were measured and findings were summarized for each retained study. A total of 2603 articles were initially identified and 10 studies, which used prospective before-and-after study design, were fully reviewed in this article. Of the 10 included studies, 9 took place in the United States, whereas the remaining was conducted in the United Kingdom. One research article focused on bar-coding implementation in a pharmacy setting, whereas the other 9 focused on bar coding within patient care areas. All 10 studies showed overall positive effects associated with bar-coding implementation. The results of this review show that bar-coding technology may reduce medication errors in hospital settings, particularly on preventing targeted wrong dose, wrong drug, wrong patient, unauthorized drug, and wrong route errors.

Clinician's Primer to ICD-10-CM Coding for Cleft Lip/Palate Care.

PubMed

Allori, Alexander C; Cragan, Janet D; Della Porta, Gina C; Mulliken, John B; Meara, John G; Bruun, Richard; Shusterman, Stephen; Cassell, Cynthia H; Raynor, Eileen; Santiago, Pedro; Marcus, Jeffrey R

2017-01-01

On October 1, 2015, the United States required use of the Clinical Modification of the International Classification of Diseases, 10th Revision (ICD-10-CM) for diagnostic coding. This primer was written to assist the cleft care community with understanding and use of ICD-10-CM for diagnostic coding related to cleft lip and/or palate (CL/P).

Software Cost Estimating,

DTIC Science & Technology

1982-05-13

Size Of The Software. A favourite measure for software system size is linos of operational code, or deliverable code (operational code plus...regression models, these conversions are either derived from productivity measures using the "cost per instruction" type of equation or they are...appropriate to different development organisattons, differert project types, different sets of units for measuring e and s, and different items

Electromagnetic reprogrammable coding-metasurface holograms.

PubMed

Li, Lianlin; Jun Cui, Tie; Ji, Wei; Liu, Shuo; Ding, Jun; Wan, Xiang; Bo Li, Yun; Jiang, Menghua; Qiu, Cheng-Wei; Zhang, Shuang

2017-08-04

Metasurfaces have enabled a plethora of emerging functions within an ultrathin dimension, paving way towards flat and highly integrated photonic devices. Despite the rapid progress in this area, simultaneous realization of reconfigurability, high efficiency, and full control over the phase and amplitude of scattered light is posing a great challenge. Here, we try to tackle this challenge by introducing the concept of a reprogrammable hologram based on 1-bit coding metasurfaces. The state of each unit cell of the coding metasurface can be switched between '1' and '0' by electrically controlling the loaded diodes. Our proof-of-concept experiments show that multiple desired holographic images can be realized in real time with only a single coding metasurface. The proposed reprogrammable hologram may be a key in enabling future intelligent devices with reconfigurable and programmable functionalities that may lead to advances in a variety of applications such as microscopy, display, security, data storage, and information processing.Realizing metasurfaces with reconfigurability, high efficiency, and control over phase and amplitude is a challenge. Here, Li et al. introduce a reprogrammable hologram based on a 1-bit coding metasurface, where the state of each unit cell of the coding metasurface can be switched electrically.

Repeats of base oligomers as the primordial coding sequences of the primeval earth and their vestiges in modern genes.

PubMed

Ohno, S

1984-01-01

Three outstanding properties uniquely qualify repeats of base oligomers as the primordial coding sequences of all polypeptide chains. First, when compared with randomly generated base sequences in general, they are more likely to have long open reading frames. Second, periodical polypeptide chains specified by such repeats are more likely to assume either alpha-helical or beta-sheet secondary structures than are polypeptide chains of random sequence. Third, provided that the number of bases in the oligomeric unit is not a multiple of 3, these internally repetitious coding sequences are impervious to randomly sustained base substitutions, deletions, and insertions. This is because the recurring periodicity of their polypeptide chains is given by three consecutive copies of the oligomeric unit translated in three different reading frames. Accordingly, when one reading frame is open, the other two are automatically open as well, all three being capable of coding for polypeptide chains of identical periodicity. Under this circumstance, a frame shift due to the deletion or insertion of a number of bases that is not a multiple of 3 fails to alter the down-stream amino acid sequence, and even a base change causing premature chain-termination can silence only one of the three potential coding units. Newly arisen coding sequences in modern organisms are oligomeric repeats, and most of the older genes retain various vestiges of their original internal repetitions. Some of the genes (e.g., oncogenes) have even inherited the property of being impervious to randomly sustained base changes.

26 CFR 1.851-7 - Certain unit investment trusts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Certain unit investment trusts. 1.851-7 Section... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.851-7 Certain unit investment trusts. (a) In general. For purposes of the Internal Revenue Code, a unit...

26 CFR 1.851-7 - Certain unit investment trusts.

Code of Federal Regulations, 2013 CFR

2013-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.851-7 Certain unit investment trusts. (a) In general. For purposes of the Internal Revenue Code, a unit... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Certain unit investment trusts. 1.851-7 Section...

26 CFR 1.851-7 - Certain unit investment trusts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.851-7 Certain unit investment trusts. (a) In general. For purposes of the Internal Revenue Code, a unit... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Certain unit investment trusts. 1.851-7 Section...

26 CFR 1.851-7 - Certain unit investment trusts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (CONTINUED) INCOME TAXES (CONTINUED) Regulated Investment Companies and Real Estate Investment Trusts § 1.851-7 Certain unit investment trusts. (a) In general. For purposes of the Internal Revenue Code, a unit... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Certain unit investment trusts. 1.851-7 Section...

26 CFR 1.851-7 - Certain unit investment trusts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Certain unit investment trusts. 1.851-7 Section... (CONTINUED) INCOME TAXES Regulated Investment Companies and Real Estate Investment Trusts § 1.851-7 Certain unit investment trusts. (a) In general. For purposes of the Internal Revenue Code, a unit investment...

Diversity of coding profiles of mechanoreceptors in glabrous skin of kittens.

PubMed

Gibson, J M; Beitel, R E; Welker, W

1975-03-21

We examined stimulul-response (S-R) profiles of 35 single mechanoreceptive afferent units having small receptive fields in glabrous forepaw skin of 24 anesthetized domestic kittens. Single unit activity was recorded with tungsten microelectrodes from cervical dorsal root ganglia. The study was designed to be as quantitatively descriptive as possible. We indented each unit's receptive field with a broad battery of simple, carefully controlled stimuli whose major parameters, including amplitude, velocity, acceleration, duration, and interstimulus interval were systematically varied. Stimuli were delivered by a small probe driven by a feedback-controlled axial displacement generator. Single unit discharge data were analyzed by a variety of direct and derived measures including dot patterns, peristimulus histograms, instantaneous and mean instantaneous firing rates, tuning curves, thresholds for amplitude and velocity, adaptation rates, dynamic and static sensitivities, and others. We found that with respect to any of the S-R transactions examined, the properties of our sample of units were continuously and broadly distributed. Any one unit might exhibit either a slow or rapid rate of adaptation, or might superficially appear to preferentially code a single stimulus parameter such as amplitude or velocity. But when the entire range of responsiveness of units to the entire stimulus battery was surveyed by a variety of analytic techniques, we were unable to find any justifiable basis for designation of discrete categories of S-R profiles. Intermediate response types were always found, and in general, all units were both broadly tuned and capable of responding to integrals of several stimulus parameters, our data argue against the usefulness of evaluating a unit's S-R coding capabilities by means of a limited ste of stimulation of response analysis procedures.

Gravitational tree-code on graphics processing units: implementation in CUDA

NASA Astrophysics Data System (ADS)

Gaburov, Evghenii; Bédorf, Jeroen; Portegies Zwart, Simon

2010-05-01

We present a new very fast tree-code which runs on massively parallel Graphical Processing Units (GPU) with NVIDIA CUDA architecture. The tree-construction and calculation of multipole moments is carried out on the host CPU, while the force calculation which consists of tree walks and evaluation of interaction list is carried out on the GPU. In this way we achieve a sustained performance of about 100GFLOP/s and data transfer rates of about 50GB/s. It takes about a second to compute forces on a million particles with an opening angle of θ ≈ 0.5. The code has a convenient user interface and is freely available for use. http://castle.strw.leidenuniv.nl/software/octgrav.html

Insight from Fukushima Daiichi Unit 3 Investigations using MELCOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R.; Francis, Matthew W.; Ott, Larry J.

During the emergency response period of the accidents that took place at Fukushima Daiichi in March of 2011, researchers at Oak Ridge National Laboratory (ORNL) conducted a number of studies using the MELCOR code to help understand what was occurring and what had occurred. During the post-accident period, the Department of Energy (DOE) and the US Nuclear Regulatory Commission (NRC) jointly sponsored a study of the Fukushima Daiichi accident with collaboration among Oak Ridge, Sandia, and Idaho national laboratories. The purpose of the study was to compile relevant data, reconstruct the accident progression using computer codes, assess the codes predictivemore » capabilities, and identify future data needs. The current paper summarizes some of the early MELCOR simulations and analyses conducted at ORNL of the Fukushima Daiichi Unit 3 accident. Extended analysis and discussion of the Unit 3 accident is also presented taking into account new knowledge and modeling refinements made since the joint DOE/NRC study.« less

Considerations of MCNP Monte Carlo code to be used as a radiotherapy treatment planning tool.

PubMed

Juste, B; Miro, R; Gallardo, S; Verdu, G; Santos, A

2005-01-01

The present work has simulated the photon and electron transport in a Theratron 780® (MDS Nordion)⁶⁰Co radiotherapy unit, using the Monte Carlo transport code, MCNP (Monte Carlo N-Particle). This project explains mainly the different methodologies carried out to speedup calculations in order to apply this code efficiently in radiotherapy treatment planning.

Research Prototype: Automated Analysis of Scientific and Engineering Semantics

NASA Technical Reports Server (NTRS)

Stewart, Mark E. M.; Follen, Greg (Technical Monitor)

2001-01-01

Physical and mathematical formulae and concepts are fundamental elements of scientific and engineering software. These classical equations and methods are time tested, universally accepted, and relatively unambiguous. The existence of this classical ontology suggests an ideal problem for automated comprehension. This problem is further motivated by the pervasive use of scientific code and high code development costs. To investigate code comprehension in this classical knowledge domain, a research prototype has been developed. The prototype incorporates scientific domain knowledge to recognize code properties (including units, physical, and mathematical quantity). Also, the procedure implements programming language semantics to propagate these properties through the code. This prototype's ability to elucidate code and detect errors will be demonstrated with state of the art scientific codes.

Simulation-based training delivered directly to the pediatric cardiac intensive care unit engenders preparedness, comfort, and decreased anxiety among multidisciplinary resuscitation teams.

PubMed

Allan, Catherine K; Thiagarajan, Ravi R; Beke, Dorothy; Imprescia, Annette; Kappus, Liana J; Garden, Alexander; Hayes, Gavin; Laussen, Peter C; Bacha, Emile; Weinstock, Peter H

2010-09-01

Resuscitation of pediatric cardiac patients involves unique and complex physiology, requiring multidisciplinary collaboration and teamwork. To optimize team performance, we created a multidisciplinary Crisis Resource Management training course that addressed both teamwork and technical skill needs for the pediatric cardiac intensive care unit. We sought to determine whether participation improved caregiver comfort and confidence levels regarding future resuscitation events. We developed a simulation-based, in situ Crisis Resource Management curriculum using pediatric cardiac intensive care unit scenarios and unit-specific resuscitation equipment, including an extracorporeal membrane oxygenation circuit. Participants replicated the composition of a clinical team. Extensive video-based debriefing followed each scenario, focusing on teamwork principles and technical resuscitation skills. Pre- and postparticipation questionnaires were used to determine the effects on participants' comfort and confidence regarding participation in future resuscitations. A total of 182 providers (127 nurses, 50 physicians, 2 respiratory therapists, 3 nurse practitioners) participated in the course. All participants scored the usefulness of the program and scenarios as 4 of 5 or higher (5 = most useful). There was significant improvement in participants' perceived ability to function as a code team member and confidence in a code (P < .001). Participants reported they were significantly more likely to raise concerns about inappropriate management to the code leader (P < .001). We developed a Crisis Resource Management training program in a pediatric cardiac intensive care unit to teach technical resuscitation skills and improve team function. Participants found the experience useful and reported improved ability to function in a code. Further work is needed to determine whether participation in the Crisis Resource Management program objectively improves team function during real resuscitations. 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

49 CFR Appendix I to Part 805 - Miscellaneous Statutory Provisions

Code of Federal Regulations, 2010 CFR

2010-10-01

... Resolution 175, 85th Congress, 2d Session (72 Stat. B12), the “Code of Ethics for Government Service.” (b) Chapter 11 of Title 18, United States Code, relating to bribery, graft, and conflicts of interest (18 U.S...

Identifying and acting on potentially inappropriate care? Inadequacy of current hospital coding for this task.

PubMed

Cooper, P David; Smart, David R

2017-06-01

Recent Australian attempts to facilitate disinvestment in healthcare, by identifying instances of 'inappropriate' care from large Government datasets, are subject to significant methodological flaws. Amongst other criticisms has been the fact that the Government datasets utilized for this purpose correlate poorly with datasets collected by relevant professional bodies. Government data derive from official hospital coding, collected retrospectively by clerical personnel, whilst professional body data derive from unit-specific databases, collected contemporaneously with care by clinical personnel. Assessment of accuracy of official hospital coding data for hyperbaric services in a tertiary referral hospital. All official hyperbaric-relevant coding data submitted to the relevant Australian Government agencies by the Royal Hobart Hospital, Tasmania, Australia for financial year 2010-2011 were reviewed and compared against actual hyperbaric unit activity as determined by reference to original source documents. Hospital coding data contained one or more errors in diagnoses and/or procedures in 70% of patients treated with hyperbaric oxygen that year. Multiple discrete error types were identified, including (but not limited to): missing patients; missing treatments; 'additional' treatments; 'additional' patients; incorrect procedure codes and incorrect diagnostic codes. Incidental observations of errors in surgical, anaesthetic and intensive care coding within this cohort suggest that the problems are not restricted to the specialty of hyperbaric medicine alone. Publications from other centres indicate that these problems are not unique to this institution or State. Current Government datasets are irretrievably compromised and not fit for purpose. Attempting to inform the healthcare policy debate by reference to these datasets is inappropriate. Urgent clinical engagement with hospital coding departments is warranted.

Empirical impact evaluation of the WHO Global Code of Practice on the International Recruitment of Health Personnel in Australia, Canada, UK and USA

PubMed Central

2013-01-01

Background The active recruitment of health workers from developing countries to developed countries has become a major threat to global health. In an effort to manage this migration, the 63rd World Health Assembly adopted the World Health Organization (WHO) Global Code of Practice on the International Recruitment of Health Personnel in May 2010. While the Code has been lauded as the first globally-applicable regulatory framework for health worker recruitment, its impact has yet to be evaluated. We offer the first empirical evaluation of the Code’s impact on national and sub-national actors in Australia, Canada, United Kingdom and United States of America, which are the English-speaking developed countries with the greatest number of migrant health workers. Methods 42 key informants from across government, civil society and private sectors were surveyed to measure their awareness of the Code, knowledge of specific changes resulting from it, overall opinion on the effectiveness of non-binding codes, and suggestions to improve this Code’s implementation. Results 60% of respondents believed their colleagues were not aware of the Code, and 93% reported that no specific changes had been observed in their work as a result of the Code. 86% reported that the Code has not had any meaningful impact on policies, practices or regulations in their countries. Conclusions This suggests a gap between awareness of the Code among stakeholders at global forums and the awareness and behaviour of national and sub-national actors. Advocacy and technical guidance for implementing the Code are needed to improve its impact on national decision-makers. PMID:24228827

Video streaming with SHVC to HEVC transcoding

NASA Astrophysics Data System (ADS)

Gudumasu, Srinivas; He, Yuwen; Ye, Yan; Xiu, Xiaoyu

2015-09-01

This paper proposes an efficient Scalable High efficiency Video Coding (SHVC) to High Efficiency Video Coding (HEVC) transcoder, which can reduce the transcoding complexity significantly, and provide a desired trade-off between the transcoding complexity and the transcoded video quality. To reduce the transcoding complexity, some of coding information, such as coding unit (CU) depth, prediction mode, merge mode, motion vector information, intra direction information and transform unit (TU) depth information, in the SHVC bitstream are mapped and transcoded to single layer HEVC bitstream. One major difficulty in transcoding arises when trying to reuse the motion information from SHVC bitstream since motion vectors referring to inter-layer reference (ILR) pictures cannot be reused directly in transcoding. Reusing motion information obtained from ILR pictures for those prediction units (PUs) will reduce the complexity of the SHVC transcoder greatly but a significant reduction in the quality of the picture is observed. Pictures corresponding to the intra refresh pictures in the base layer (BL) will be coded as P pictures in enhancement layer (EL) in the SHVC bitstream; and directly reusing the intra information from the BL for transcoding will not get a good coding efficiency. To solve these problems, various transcoding technologies are proposed. The proposed technologies offer different trade-offs between transcoding speed and transcoding quality. They are implemented on the basis of reference software SHM-6.0 and HM-14.0 for the two layer spatial scalability configuration. Simulations show that the proposed SHVC software transcoder reduces the transcoding complexity by up to 98-99% using low complexity transcoding mode when compared with cascaded re-encoding method. The transcoder performance at various bitrates with different transcoding modes are compared in terms of transcoding speed and transcoded video quality.

Unified method of knowledge representation in the evolutionary artificial intelligence systems

NASA Astrophysics Data System (ADS)

Bykov, Nickolay M.; Bykova, Katherina N.

2003-03-01

The evolution of artificial intelligence systems called by complicating of their operation topics and science perfecting has resulted in a diversification of the methods both the algorithms of knowledge representation and usage in these systems. Often by this reason it is very difficult to design the effective methods of knowledge discovering and operation for such systems. In the given activity the authors offer a method of unitized representation of the systems knowledge about objects of an external world by rank transformation of their descriptions, made in the different features spaces: deterministic, probabilistic, fuzzy and other. The proof of a sufficiency of the information about the rank configuration of the object states in the features space for decision making is presented. It is shown that the geometrical and combinatorial model of the rank configurations set introduce their by group of some system of incidence, that allows to store the information on them in a convolute kind. The method of the rank configuration description by the DRP - code (distance rank preserving code) is offered. The problems of its completeness, information capacity, noise immunity and privacy are reviewed. It is shown, that the capacity of a transmission channel for such submission of the information is more than unit, as the code words contain the information both about the object states, and about the distance ranks between them. The effective algorithm of the data clustering for the object states identification, founded on the given code usage, is described. The knowledge representation with the help of the rank configurations allows to unitize and to simplify algorithms of the decision making by fulfillment of logic operations above the DRP - code words. Examples of the proposed clustering techniques operation on the given samples set, the rank configuration of resulted clusters and its DRP-codes are presented.

Hurricane Harvey Riverine Flooding: Part 1 - Reconstruction of Hurricane Harvey Flooding for Harris County, TX using a GPU-accelerated 2D flood model for post-flood hazard analysis

NASA Astrophysics Data System (ADS)

Kalyanapu, A. J.; Dullo, T. T.; Gangrade, S.; Kao, S. C.; Marshall, R.; Islam, S. R.; Ghafoor, S. K.

2017-12-01

Hurricane Harvey that made landfall in the southern Texas this August is one of the most destructive hurricanes during the 2017 hurricane season. During its active period, many areas in coastal Texas region received more than 40 inches of rain. This downpour caused significant flooding resulting in about 77 casualties, displacing more than 30,000 people, inundating hundreds of thousands homes and is currently estimated to have caused more than $70 billion in direct damage. One of the significantly affected areas is Harris County where the city of Houston, TX is located. Covering over two HUC-8 drainage basins ( 2702 mi2), this county experienced more than 80% of its annual average rainfall during this event. This study presents an effort to reconstruct flooding caused by extreme rainfall due to Hurricane Harvey in Harris County, Texas. This computationally intensive task was performed at a 30-m spatial resolution using a rapid flood model called Flood2D-GPU, a graphics processing unit (GPU) accelerated model, on Oak Ridge National Laboratory's (ORNL) Titan Supercomputer. For this task, the hourly rainfall estimates from the National Center for Environmental Prediction Stage IV Quantitative Precipitation Estimate were fed into the Variable Infiltration Capacity (VIC) hydrologic model and Routing Application for Parallel computation of Discharge (RAPID) routing model to estimate flow hydrographs at 69 locations for Flood2D-GPU simulation. Preliminary results of the simulation including flood inundation extents, maps of flood depths and inundation duration will be presented. Future efforts will focus on calibrating and validating the simulation results and assessing the flood damage for better understanding the impacts made by Hurricane Harvey.

Clinical laboratory sciences data transmission : the NPU coding system

PubMed Central

PONTET, Françoise; PETERSEN, Ulla MAGDAL; FUENTES-ARDERIU, Xavier; NORDIN, Gunnar; BRUUNSHUUS, Ivan; IHALAINEN, Jarkko; KARLSSON, Daniel; FORSUM, Urban; DYBKAER, René; SCHADOW, Gunther; KUELPMANN, Wolf; FÉRARD, Georges; KANG, Dongchon; McDONALD, Clement; HILL, Gilbert

2011-01-01

Introduction In health care services, technology requires that correct information be duly available to professionals, citizens and authorities, worldwide. Thus, clinical laboratory sciences require standardized electronic exchanges for results of laboratory examinations. Methods. The NPU (Nomenclature, Properties and Units) coding system provides a terminology for identification of result values (property values). It is structured according to BIPM, ISO, IUPAC and IFCC recommendations. It uses standard terms for established concepts and structured definitions describing: which part of the universe is examined, which component of relevance in that part, which kind-of-property is relevant. Unit and specifications can be added where relevant [System(spec) Component(spec); kind-of-property(spec) = ? unit]. Results. The English version of this terminology is freely accessible at http://dior.imt.liu.se/cnpu/ and http://www.labterm.dk, directly or through the IFCC and IUPAC websites. It has been nationally used for more than 10 years in Denmark and Sweden and has been translated into 6 other languages. Conclusions. The NPU coding system provides a terminology for dedicated kinds-of-property following the international recommendations. It fits well in the health network and is freely accessible. Clinical laboratory professionals worldwide will find many advantages in using the NPU coding system, notably with regards to an accreditation process. PMID:19745311

Industrial Facility Combustion Energy Use

DOE Data Explorer

McMillan, Colin

2016-08-01

Facility-level industrial combustion energy use is calculated from greenhouse gas emissions data reported by large emitters (>25,000 metric tons CO2e per year) under the U.S. EPA's Greenhouse Gas Reporting Program (GHGRP, https://www.epa.gov/ghgreporting). The calculation applies EPA default emissions factors to reported fuel use by fuel type. Additional facility information is included with calculated combustion energy values, such as industry type (six-digit NAICS code), location (lat, long, zip code, county, and state), combustion unit type, and combustion unit name. Further identification of combustion energy use is provided by calculating energy end use (e.g., conventional boiler use, co-generation/CHP use, process heating, other facility support) by manufacturing NAICS code. Manufacturing facilities are matched by their NAICS code and reported fuel type with the proportion of combustion fuel energy for each end use category identified in the 2010 Energy Information Administration Manufacturing Energy Consumption Survey (MECS, http://www.eia.gov/consumption/manufacturing/data/2010/). MECS data are adjusted to account for data that were withheld or whose end use was unspecified following the procedure described in Fox, Don B., Daniel Sutter, and Jefferson W. Tester. 2011. The Thermal Spectrum of Low-Temperature Energy Use in the United States, NY: Cornell Energy Institute.

Simultaneous Semi-Distributed Model Calibration Guided by ...

EPA Pesticide Factsheets

Modelling approaches to transfer hydrologically-relevant information from locations with streamflow measurements to locations without such measurements continues to be an active field of research for hydrologists. The Pacific Northwest Hydrologic Landscapes (PNW HL) provide a solid conceptual classification framework based on our understanding of dominant processes. A Hydrologic Landscape code (5 letter descriptor based on physical and climatic properties) describes each assessment unit area, and these units average area 60km2. The core function of these HL codes is to relate and transfer hydrologically meaningful information between watersheds without the need for streamflow time series. We present a novel approach based on the HL framework to answer the question “How can we calibrate models across separate watersheds simultaneously, guided by our understanding of dominant processes?“. We should be able to apply the same parameterizations to assessment units of common HL codes if 1) the Hydrologic Landscapes contain hydrologic information transferable between watersheds at a sub-watershed-scale and 2) we use a conceptual hydrologic model and parameters that reflect the hydrologic behavior of a watershed. In this study, This work specifically tests the ability or inability to use HL-codes to inform and share model parameters across watersheds in the Pacific Northwest. EPA’s Western Ecology Division has published and is refining a framework for defining la

Clinical laboratory sciences data transmission: the NPU coding system.

PubMed

Pontet, Françoise; Magdal Petersen, Ulla; Fuentes-Arderiu, Xavier; Nordin, Gunnar; Bruunshuus, Ivan; Ihalainen, Jarkko; Karlsson, Daniel; Forsum, Urban; Dybkaer, René; Schadow, Gunther; Kuelpmann, Wolf; Férard, Georges; Kang, Dongchon; McDonald, Clement; Hill, Gilbert

2009-01-01

In health care services, technology requires that correct information be duly available to professionals, citizens and authorities, worldwide. Thus, clinical laboratory sciences require standardized electronic exchanges for results of laboratory examinations. The NPU (Nomenclature, Properties and Units) coding system provides a terminology for identification of result values (property values). It is structured according to BIPM, ISO, IUPAC and IFCC recommendations. It uses standard terms for established concepts and structured definitions describing: which part of the universe is examined, which component of relevance in that part, which kind-of-property is relevant. Unit and specifications can be added where relevant [System(spec)-Component(spec); kind-of-property(spec) = ? unit]. The English version of this terminology is freely accessible at http://dior.imt.liu.se/cnpu/ and http://www.labterm.dk, directly or through the IFCC and IUPAC websites. It has been nationally used for more than 10 years in Denmark and Sweden and has been translated into 6 other languages. The NPU coding system provides a terminology for dedicated kinds-of-property following the international recommendations. It fits well in the health network and is freely accessible. Clinical laboratory professionals worldwide will find many advantages in using the NPU coding system, notably with regards to an accreditation process.

Mock Code: A Code Blue Scenario Requested by and Developed for Registered Nurses

PubMed Central

Rideout, Janice; Pritchett-Kelly, Sherry; McDonald, Melissa; Mullins-Richards, Paula; Dubrowski, Adam

2016-01-01

The use of simulation in medical training is quickly becoming more common, with applications in emergency, surgical, and nursing education. Recently, registered nurses working in surgical inpatient units requested a mock code simulation to practice skills, improve knowledge, and build self-confidence in a safe and controlled environment. A simulation scenario using a high-fidelity mannequin was developed and will be discussed herein. PMID:28123919

OCTGRAV: Sparse Octree Gravitational N-body Code on Graphics Processing Units

NASA Astrophysics Data System (ADS)

Gaburov, Evghenii; Bédorf, Jeroen; Portegies Zwart, Simon

2010-10-01

Octgrav is a very fast tree-code which runs on massively parallel Graphical Processing Units (GPU) with NVIDIA CUDA architecture. The algorithms are based on parallel-scan and sort methods. The tree-construction and calculation of multipole moments is carried out on the host CPU, while the force calculation which consists of tree walks and evaluation of interaction list is carried out on the GPU. In this way, a sustained performance of about 100GFLOP/s and data transfer rates of about 50GB/s is achieved. It takes about a second to compute forces on a million particles with an opening angle of heta approx 0.5. To test the performance and feasibility, we implemented the algorithms in CUDA in the form of a gravitational tree-code which completely runs on the GPU. The tree construction and traverse algorithms are portable to many-core devices which have support for CUDA or OpenCL programming languages. The gravitational tree-code outperforms tuned CPU code during the tree-construction and shows a performance improvement of more than a factor 20 overall, resulting in a processing rate of more than 2.8 million particles per second. The code has a convenient user interface and is freely available for use.

A Fast MHD Code for Gravitationally Stratified Media using Graphical Processing Units: SMAUG

NASA Astrophysics Data System (ADS)

Griffiths, M. K.; Fedun, V.; Erdélyi, R.

2015-03-01

Parallelization techniques have been exploited most successfully by the gaming/graphics industry with the adoption of graphical processing units (GPUs), possessing hundreds of processor cores. The opportunity has been recognized by the computational sciences and engineering communities, who have recently harnessed successfully the numerical performance of GPUs. For example, parallel magnetohydrodynamic (MHD) algorithms are important for numerical modelling of highly inhomogeneous solar, astrophysical and geophysical plasmas. Here, we describe the implementation of SMAUG, the Sheffield Magnetohydrodynamics Algorithm Using GPUs. SMAUG is a 1-3D MHD code capable of modelling magnetized and gravitationally stratified plasma. The objective of this paper is to present the numerical methods and techniques used for porting the code to this novel and highly parallel compute architecture. The methods employed are justified by the performance benchmarks and validation results demonstrating that the code successfully simulates the physics for a range of test scenarios including a full 3D realistic model of wave propagation in the solar atmosphere.

Optimizing the use of a sensor resource for opponent polarization coding

PubMed Central

Heras, Francisco J.H.

2017-01-01

Flies use specialized photoreceptors R7 and R8 in the dorsal rim area (DRA) to detect skylight polarization. R7 and R8 form a tiered waveguide (central rhabdomere pair, CRP) with R7 on top, filtering light delivered to R8. We examine how the division of a given resource, CRP length, between R7 and R8 affects their ability to code polarization angle. We model optical absorption to show how the length fractions allotted to R7 and R8 determine the rates at which they transduce photons, and correct these rates for transduction unit saturation. The rates give polarization signal and photon noise in R7, and in R8. Their signals are combined in an opponent unit, intrinsic noise added, and the unit’s output analysed to extract two measures of coding ability, number of discriminable polarization angles and mutual information. A very long R7 maximizes opponent signal amplitude, but codes inefficiently due to photon noise in the very short R8. Discriminability and mutual information are optimized by maximizing signal to noise ratio, SNR. At lower light levels approximately equal lengths of R7 and R8 are optimal because photon noise dominates. At higher light levels intrinsic noise comes to dominate and a shorter R8 is optimum. The optimum R8 length fractions falls to one third. This intensity dependent range of optimal length fractions corresponds to the range observed in different fly species and is not affected by transduction unit saturation. We conclude that a limited resource, rhabdom length, can be divided between two polarization sensors, R7 and R8, to optimize opponent coding. We also find that coding ability increases sub-linearly with total rhabdom length, according to the law of diminishing returns. Consequently, the specialized shorter central rhabdom in the DRA codes polarization twice as efficiently with respect to rhabdom length than the longer rhabdom used in the rest of the eye. PMID:28316880

Serial turbo trellis coded modulation using a serially concatenated coder

NASA Technical Reports Server (NTRS)

Divsalar, Dariush (Inventor); Dolinar, Samuel J. (Inventor); Pollara, Fabrizio (Inventor)

2010-01-01

Serial concatenated trellis coded modulation (SCTCM) includes an outer coder, an interleaver, a recursive inner coder and a mapping element. The outer coder receives data to be coded and produces outer coded data. The interleaver permutes the outer coded data to produce interleaved data. The recursive inner coder codes the interleaved data to produce inner coded data. The mapping element maps the inner coded data to a symbol. The recursive inner coder has a structure which facilitates iterative decoding of the symbols at a decoder system. The recursive inner coder and the mapping element are selected to maximize the effective free Euclidean distance of a trellis coded modulator formed from the recursive inner coder and the mapping element. The decoder system includes a demodulation unit, an inner SISO (soft-input soft-output) decoder, a deinterleaver, an outer SISO decoder, and an interleaver.

Future Research Needs for Dredgeability of Rock: Rock Dredging Workshop Held in Jacksonville, Florida on 25-26 July 1985.

DTIC Science & Technology

1986-09-01

ORGANIZATION Gjeoteehnical Laborator WESGR-M 6c ADDRESS (City, Slate, and ZIP Code ) 7b ADDRESS(City, State. and ZIP Code ) PO Box 631 Vicksburg, MS 39180...of Engineers 8< ADDRESS(City, State, and ZIP Code ) 10 SOURCE OF FUNDING NUMBERS PROGRAM PROJECT TASK WORK UNIT.. ", 1 :, • ; I, - u It ., " ’ ~f...Springfield, VA 22161 17 COSATI CODES 18 SUBJECT TERMS (Continue-On revprse of necessary and identify by block number) " FIELD GROUP SUB GROUP

Volume accumulator design analysis computer codes

NASA Technical Reports Server (NTRS)

Whitaker, W. D.; Shimazaki, T. T.

1973-01-01

The computer codes, VANEP and VANES, were written and used to aid in the design and performance calculation of the volume accumulator units (VAU) for the 5-kwe reactor thermoelectric system. VANEP computes the VAU design which meets the primary coolant loop VAU volume and pressure performance requirements. VANES computes the performance of the VAU design, determined from the VANEP code, at the conditions of the secondary coolant loop. The codes can also compute the performance characteristics of the VAU's under conditions of possible modes of failure which still permit continued system operation.

The Differentiation of Human Adipose-Derived Stem Cells towards a Urothelium-Like Phenotype In Vitro and the Dynamic Temporal Changes of Related Cytokines by Both Paracrine and Autocrine Signal Regulation

PubMed Central

Zhou, Zhe; Zhang, Ke; Zhou, Juan; Zhao, Yang; Wang, Zhong; Lu, Mu-jun

2014-01-01

Purpose To investigate the differentiation ability of human adipose-derived stem cells (ASCs) towards urothelium-like cells in vitro and the dynamic changes of related cytokines and cytokine receptors in the culture medium. Materials and Methods The ASCs were induced using both conditioned media (CM) and the transwell co-culture system with an immortalized urothelium cell line (SV-HUC-1,HUC) for 21 days. Protein and mRNA expression of the mature urothelium specific markers uroplakin-IA (UP-1A) and uroplakin-II (UP-II) were detected by immunofluorescence and quantitative real-time PCR, respectively. Array detection was used to screen 41 cytokines and receptors in the upper medium of urothelium, non-induced ASCs and urothelium-induced ASCs at three time points, early (12 hours), intermediate (7 days) and late (21 days). Results After induction for 7 days, the ASCs grown in both CM and transwell co-culture system expressed uroplakin-IA (13.54±2.00%; 17.28±1.84%) and uroplakin-II (19.49±1.73%; 13.98±1.47%). After induction for 21 days, ASCs grown in co-culture had significantly increased expression of uroplakin-IA (48.03±1.25%; 49.57±2.85%) and uroplakin-II (45.38±2.50%; 46.58±1.95%). In the upper medium of urothelium, 28 cytokines and 8 cytokine receptors had significantly higher expression than the counterpart of non-induced ASCs. After 7 days induction, the expression of 22 cytokines and 8 cytokine receptors was significantly elevated in the upper medium of induced ASCs compared to non-induced ASCs. At the early and intermediate time points, ASCs secreted high levels of relative cytokines and soluble receptors, but their expressions decreased significantly at the late time point. Conclusion The adipose-derived stem cells have the potential to be differentiated into urothelium-like cells in vitro by both CM and transwell co-culture system with mature urothelium. Numerous cytokines and receptors were involved in the differentiation process with dynamic temporal changes by both paracrine and autocrine signal regulation. Further studies should be carried out to determine the detailed mechanism of cytokines and receptors and to enhance the urothelium differentiation efficiency of ASCs. PMID:24752317

The differentiation of human adipose-derived stem cells towards a urothelium-like phenotype in vitro and the dynamic temporal changes of related cytokines by both paracrine and autocrine signal regulation.

PubMed

Zhang, Ming; Xu, Ming-Xi; Zhou, Zhe; Zhang, Ke; Zhou, Juan; Zhao, Yang; Wang, Zhong; Lu, Mu-Jun

2014-01-01

To investigate the differentiation ability of human adipose-derived stem cells (ASCs) towards urothelium-like cells in vitro and the dynamic changes of related cytokines and cytokine receptors in the culture medium. The ASCs were induced using both conditioned media (CM) and the transwell co-culture system with an immortalized urothelium cell line (SV-HUC-1,HUC) for 21 days. Protein and mRNA expression of the mature urothelium specific markers uroplakin-IA (UP-1A) and uroplakin-II (UP-II) were detected by immunofluorescence and quantitative real-time PCR, respectively. Array detection was used to screen 41 cytokines and receptors in the upper medium of urothelium, non-induced ASCs and urothelium-induced ASCs at three time points, early (12 hours), intermediate (7 days) and late (21 days). After induction for 7 days, the ASCs grown in both CM and transwell co-culture system expressed uroplakin-IA (13.54±2.00%; 17.28±1.84%) and uroplakin-II (19.49±1.73%; 13.98±1.47%). After induction for 21 days, ASCs grown in co-culture had significantly increased expression of uroplakin-IA (48.03±1.25%; 49.57±2.85%) and uroplakin-II (45.38±2.50%; 46.58±1.95%). In the upper medium of urothelium, 28 cytokines and 8 cytokine receptors had significantly higher expression than the counterpart of non-induced ASCs. After 7 days induction, the expression of 22 cytokines and 8 cytokine receptors was significantly elevated in the upper medium of induced ASCs compared to non-induced ASCs. At the early and intermediate time points, ASCs secreted high levels of relative cytokines and soluble receptors, but their expressions decreased significantly at the late time point. The adipose-derived stem cells have the potential to be differentiated into urothelium-like cells in vitro by both CM and transwell co-culture system with mature urothelium. Numerous cytokines and receptors were involved in the differentiation process with dynamic temporal changes by both paracrine and autocrine signal regulation. Further studies should be carried out to determine the detailed mechanism of cytokines and receptors and to enhance the urothelium differentiation efficiency of ASCs.

Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma.

PubMed

Brait, Mariana; Munari, Enrico; LeBron, Cynthia; Noordhuis, Maartje G; Begum, Shahnaz; Michailidi, Christina; Gonzalez-Roibon, Nilda; Maldonado, Leonel; Sen, Tanusree; Guerrero-Preston, Rafael; Cope, Leslie; Parrella, Paola; Fazio, Vito Michele; Ha, Patrick K; Netto, George J; Sidransky, David; Hoque, Mohammad O

2013-04-01

Urothelial cell carcinoma (UCC) is the second most common genitourinary malignant disease in the USA, and tobacco smoking is the major known risk factor for UCC development. Exposure to carcinogens, such as those contained in tobacco smoke, is known to directly or indirectly damage DNA, causing mutations, chromosomal deletion events and epigenetic alterations in UCC. Molecular studies have shown that chromosome 9 alterations and P53, RAS, RB and PTEN mutations are among the most frequent events in UCC. Recent studies suggested that continuous tobacco carcinogen exposure drives and enhances the selection of epigenetically altered cells in UCC, predominantly in the invasive form of the disease. However, the sequence of molecular events that leads to UCC after exposure to tobacco smoke is not well understood. To elucidate molecular events that lead to UCC oncogenesis and progression after tobacco exposure, we developed an in vitro cellular model for smoking-induced UCC. SV-40 immortalized normal HUC1 human bladder epithelial cells were continuously exposed to 0.1% cigarette smoke extract (CSE) until transformation occurred. Morphological alterations and increased cell proliferation of non-malignant urothelial cells were observed after 4 months (mo) of treatment with CSE. Anchorage-independent growth assessed by soft agar assay and increase in the migratory and invasive potential was observed in urothelial cells after 6 mo of CSE treatment. By performing a PCR mRNA expression array specific to the PI3K-AKT pathway, we found that 26 genes were upregulated and 22 genes were downregulated after 6 mo of CSE exposure of HUC1 cells. Among the altered genes, PTEN, FOXO1, MAPK1 and PDK1 were downregulated in the transformed cells, while AKT1, AKT2, HRAS, RAC1 were upregulated. Validation by RT-PCR and western blot analysis was then performed. Furthermore, genome-wide methylation analysis revealed MCAM, DCC and HIC1 are hypermethylated in CSE-treated urothelial cells when compared with non-CSE exposed cells. The methylation status of these genes was validated using quantitative methylation-specific PCR (QMSP), confirming an increase in methylation of CSE-treated urothelial cells compared to untreated controls. Therefore, our findings suggest that a tobacco signature could emerge from distinctive patterns of genetic and epigenetic alterations and can be identified using an in vitro cellular model for the development of smoking-induced cancer.

Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma

PubMed Central

Brait, Mariana; Munari, Enrico; LeBron, Cynthia; Noordhuis, Maartje G.; Begum, Shahnaz; Michailidi, Christina; Gonzalez-Roibon, Nilda; Maldonado, Leonel; Sen, Tanusree; Guerrero-Preston, Rafael; Cope, Leslie; Parrella, Paola; Fazio, Vito Michele; Ha, Patrick K.; Netto, George J.; Sidransky, David; Hoque, Mohammad O.

2013-01-01

Urothelial cell carcinoma (UCC) is the second most common genitourinary malignant disease in the USA, and tobacco smoking is the major known risk factor for UCC development. Exposure to carcinogens, such as those contained in tobacco smoke, is known to directly or indirectly damage DNA, causing mutations, chromosomal deletion events and epigenetic alterations in UCC. Molecular studies have shown that chromosome 9 alterations and P53, RAS, RB and PTEN mutations are among the most frequent events in UCC. Recent studies suggested that continuous tobacco carcinogen exposure drives and enhances the selection of epigenetically altered cells in UCC, predominantly in the invasive form of the disease. However, the sequence of molecular events that leads to UCC after exposure to tobacco smoke is not well understood. To elucidate molecular events that lead to UCC oncogenesis and progression after tobacco exposure, we developed an in vitro cellular model for smoking-induced UCC. SV-40 immortalized normal HUC1 human bladder epithelial cells were continuously exposed to 0.1% cigarette smoke extract (CSE) until transformation occurred. Morphological alterations and increased cell proliferation of non-malignant urothelial cells were observed after 4 months (mo) of treatment with CSE. Anchorage-independent growth assessed by soft agar assay and increase in the migratory and invasive potential was observed in urothelial cells after 6 mo of CSE treatment. By performing a PCR mRNA expression array specific to the PI3K-AKT pathway, we found that 26 genes were upregulated and 22 genes were downregulated after 6 mo of CSE exposure of HUC1 cells. Among the altered genes, PTEN, FOXO1, MAPK1 and PDK1 were downregulated in the transformed cells, while AKT1, AKT2, HRAS, RAC1 were upregulated. Validation by RT-PCR and western blot analysis was then performed. Furthermore, genome-wide methylation analysis revealed MCAM, DCC and HIC1 are hypermethylated in CSE-treated urothelial cells when compared with non-CSE exposed cells. The methylation status of these genes was validated using quantitative methylation-specific PCR (QMSP), confirming an increase in methylation of CSE-treated urothelial cells compared to untreated controls. Therefore, our findings suggest that a tobacco signature could emerge from distinctive patterns of genetic and epigenetic alterations and can be identified using an in vitro cellular model for the development of smoking-induced cancer. PMID:23435205

10 CFR 1014.10 - Action on approved claims.

Code of Federal Regulations, 2010 CFR

2010-01-01

... against the United States and against any employee of the Government whose act or omission gave rise to... 2677 of title 28, United States Code, that acceptance shall be final and conclusive on the claimant...

3 CFR 13572 - Executive Order 13572 of April 29, 2011. Blocking Property of Certain Persons With Respect to...

Code of Federal Regulations, 2012 CFR

2012-01-01

... Constitution and the laws of the United States of America, including the International Emergency Economic... section 301 of title 3, United States Code, I, BARACK OBAMA, President of the United States of America...: Section 1. All property and interests in property that are in the United States, that hereafter come...

EPA Office of Water (OW): 12-digit Hydrologic Unit Boundaries of the United States

EPA Pesticide Factsheets

The Watershed Boundary Dataset (WBD) is a complete digital hydrologic unit national boundary layer that is at the Subwatershed (12-digit) level. It is composed of the watershed boundaries delineated by state agencies at the 1:24,000 scale. Please refer to the individual state metadata as the primary reference source. To access state specific metadata, go to the following link to view documentation created by agencies that performed the watershed delineation. This data set is a complete digital hydrologic unit boundary layer to the Subwatershed (12-digit) 6th level. This data set consists of geo-referenced digital data and associated attributes created in accordance with the FGDC Proposal, Version 1.0 - Federal Standards For Delineation of Hydrologic Unit Boundaries 3/01/02. Polygons are attributed with hydrologic unit codes for 4th level sub-basins, 5th level watersheds, 6th level subwatersheds, name, size, downstream hydrologic unit, type of watershed, non-contributing areas and flow modification. Arcs are attributed with the highest hydrologic unit code for each watershed, linesource and a metadata reference file.Please refer to the Metadata contact if you want access to the WBD national data set.

5 CFR 890.1303 - Eligibility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... EMPLOYEES HEALTH BENEFITS PROGRAM Department of Defense Federal Employees Health Benefits Program... Code, for self-only coverage or for self and family coverage. A self and family enrollment will include... family” in section 8901(5) of title 5, United States Code. A self and family enrollment will not cover a...

5 CFR 890.1303 - Eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... EMPLOYEES HEALTH BENEFITS PROGRAM Department of Defense Federal Employees Health Benefits Program... Code, for self-only coverage or for self and family coverage. A self and family enrollment will include... family” in section 8901(5) of title 5, United States Code. A self and family enrollment will not cover a...

5 CFR 550.103 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL... subchapter V of chapter 55 of title 5, United States Code. Basic workweek, for full-time employees, means the... Foreign Service primary skill code of 2501; (4) Who is a special agent in the Diplomatic Security Service...

A multidisciplinary approach to vascular surgery procedure coding improves coding accuracy, work relative value unit assignment, and reimbursement.

PubMed

Aiello, Francesco A; Judelson, Dejah R; Messina, Louis M; Indes, Jeffrey; FitzGerald, Gordon; Doucet, Danielle R; Simons, Jessica P; Schanzer, Andres

2016-08-01

Vascular surgery procedural reimbursement depends on accurate procedural coding and documentation. Despite the critical importance of correct coding, there has been a paucity of research focused on the effect of direct physician involvement. We hypothesize that direct physician involvement in procedural coding will lead to improved coding accuracy, increased work relative value unit (wRVU) assignment, and increased physician reimbursement. This prospective observational cohort study evaluated procedural coding accuracy of fistulograms at an academic medical institution (January-June 2014). All fistulograms were coded by institutional coders (traditional coding) and by a single vascular surgeon whose codes were verified by two institution coders (multidisciplinary coding). The coding methods were compared, and differences were translated into revenue and wRVUs using the Medicare Physician Fee Schedule. Comparison between traditional and multidisciplinary coding was performed for three discrete study periods: baseline (period 1), after a coding education session for physicians and coders (period 2), and after a coding education session with implementation of an operative dictation template (period 3). The accuracy of surgeon operative dictations during each study period was also assessed. An external validation at a second academic institution was performed during period 1 to assess and compare coding accuracy. During period 1, traditional coding resulted in a 4.4% (P = .004) loss in reimbursement and a 5.4% (P = .01) loss in wRVUs compared with multidisciplinary coding. During period 2, no significant difference was found between traditional and multidisciplinary coding in reimbursement (1.3% loss; P = .24) or wRVUs (1.8% loss; P = .20). During period 3, traditional coding yielded a higher overall reimbursement (1.3% gain; P = .26) than multidisciplinary coding. This increase, however, was due to errors by institution coders, with six inappropriately used codes resulting in a higher overall reimbursement that was subsequently corrected. Assessment of physician documentation showed improvement, with decreased documentation errors at each period (11% vs 3.1% vs 0.6%; P = .02). Overall, between period 1 and period 3, multidisciplinary coding resulted in a significant increase in additional reimbursement ($17.63 per procedure; P = .004) and wRVUs (0.50 per procedure; P = .01). External validation at a second academic institution was performed to assess coding accuracy during period 1. Similar to institution 1, traditional coding revealed an 11% loss in reimbursement ($13,178 vs $14,630; P = .007) and a 12% loss in wRVU (293 vs 329; P = .01) compared with multidisciplinary coding. Physician involvement in the coding of endovascular procedures leads to improved procedural coding accuracy, increased wRVU assignments, and increased physician reimbursement. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Is the orthographic/phonological onset a single unit in reading aloud?

PubMed

Mousikou, Petroula; Coltheart, Max; Saunders, Steven; Yen, Lisa

2010-02-01

Two main theories of visual word recognition have been developed regarding the way orthographic units in printed words map onto phonological units in spoken words. One theory suggests that a string of single letters or letter clusters corresponds to a string of phonemes (Coltheart, 1978; Venezky, 1970), while the other suggests that a string of single letters or letter clusters corresponds to coarser phonological units, for example, onsets and rimes (Treiman & Chafetz, 1987). These theoretical assumptions were critical for the development of coding schemes in prominent computational models of word recognition and reading aloud. In a reading-aloud study, we tested whether the human reading system represents the orthographic/phonological onset of printed words and nonwords as single units or as separate letters/phonemes. Our results, which favored a letter and not an onset-coding scheme, were successfully simulated by the dual-route cascaded (DRC) model (Coltheart, Rastle, Perry, Langdon, & Ziegler, 2001). A separate experiment was carried out to further adjudicate between 2 versions of the DRC model.

Electrical generating unit inventory, 1976-1986: Illinois, Indiana, Kentucky, Ohio, Pennsylvania and West Virginia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jansen, S.D.

1981-09-01

The report was prepared as part of the Ohio River Basin Energy Study (ORBES), a multidisciplinary policy research program. The ORBES region consists of all of Kentucky, most of West Virginia, substantial parts of Illinois, Indiana, and Ohio, and southwestern Pennsylvania. The inventory lists installed electrical generating capacity in commercial service as of December 1, 1976, and scheduled capacity additions and removals between 1977 and 1986 in the six ORBES states (Illinois, Indiana, Kentucky, Ohio, Pennsylvania, and West Virginia). The following information is included for each electrical generating unit: unit ID code, company index, whether joint or industrial ownership, plantmore » name, whether inside or outside the ORBES region, FIPS county code, type of unit, size in megawatts, type of megawatt rating, status of unit, date of commercial operation (actual or scheduled), scheduled retirement date (if any), primary fuel, alternate fuel, type of cooling, source of cooling water, and source of information.« less

Nonlinear Real-Time Optical Signal Processing.

DTIC Science & Technology

1988-07-01

Principal Investigator B. K. Jenkins Signal and Image Processing Institute University of Southern California Mail Code 0272 Los Angeles, California...ADDRESS (09% SteW. Mnd ZIP Code ) 10. SOURC OF FUNONG NUMBERS Bldg. 410, Bolling AFB PROGAM CT TASK WORK UNIT Washington, D.C. 20332 EEETP.aso o 11...TAB Unmnnncced Justification By Distribution/ I O’ Availablility Codes I - ’_ ji and/or 2 I Summary During the period 1 July 1987 - 30 June 1988, the

5 CFR 630.1301 - Purpose and applicability.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the Armed Forces of the United States serving on active duty during the Persian Gulf War and who... and employees— (1) To whom subchapter IV of chapter 63 of title 5, United States Code, applies; and (2...

5 CFR 630.1301 - Purpose and applicability.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the Armed Forces of the United States serving on active duty during the Persian Gulf War and who... and employees— (1) To whom subchapter IV of chapter 63 of title 5, United States Code, applies; and (2...

5 CFR 630.1301 - Purpose and applicability.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the Armed Forces of the United States serving on active duty during the Persian Gulf War and who... and employees— (1) To whom subchapter IV of chapter 63 of title 5, United States Code, applies; and (2...

5 CFR 630.1301 - Purpose and applicability.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the Armed Forces of the United States serving on active duty during the Persian Gulf War and who... and employees— (1) To whom subchapter IV of chapter 63 of title 5, United States Code, applies; and (2...

5 CFR 630.1301 - Purpose and applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... the Armed Forces of the United States serving on active duty during the Persian Gulf War and who... and employees— (1) To whom subchapter IV of chapter 63 of title 5, United States Code, applies; and (2...

Population and Housing Unit Estimates

Science.gov Websites

United States Census Bureau Topics Population Latest Information Age and Sex Ancestry Children Mobility Population Estimates Population Projections Race Veterans Economy Latest Information Portal Other Economic Programs Business Latest Information Business Characteristics Classification Codes

33 CFR 160.113 - Prohibition of vessel operation and cargo transfers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of chapter 37 of Title 46, U.S. Code, from operating in the navigable waters of the United States, or from transferring cargo or residue in any port or place under the jurisdiction of the United States... or treaty of the United States; (3) Does not comply with applicable vessel traffic service...

Ecological subregion codes by county, coterminous United States

Treesearch

Victor A. Rudis

1999-01-01

This publication presents the National Hierarchical Framework of Ecological Units (ECOMAP 1993) by county for the coterminous United States. Assignment of the framework to individual counties is based on the predominant area by province and section to facilitate integration of county-referenced information with areas of uniform ecological potential. Included are maps...

A Basic Unit on Ethics for Technical Communicators.

ERIC Educational Resources Information Center

Markel, Mike

1991-01-01

Describes a basic unit on ethics for technical communicators and offers suggestions on how to go about teaching the unit. Includes a brief definition of ethics, an explanation of the employee's three basic obligations, ways to analyze common dilemmas in technical communication, the role of the code of conduct, and a case study. (SR)

31 CFR Appendix A to Part 589 - Executive Order 13660

Code of Federal Regulations, 2014 CFR

2014-07-01

... Constitution and the laws of the United States of America, including the International Emergency Economic... 3, United States Code, I, BARACK OBAMA, President of the United States of America, find that the... deal with that threat. I hereby order: Section 1. (a) All property and interests in property that are...

Unit-Credit Titles under Program Headings, Directory. Technology Education: Vocational Industrial, Industrial Arts, Home Economics.

ERIC Educational Resources Information Center

Manitoba Dept. of Education and Training, Winnipeg. Curriculum Services Branch.

This directory lists the unit-credit titles of the technology education courses offered in Manitoba, along with their corresponding department codes and course numbers. Sections A through C list the unit-credit titles of the following vocational-industrial clusters: heavy industrial (agriculture, auto body repair, building construction, building…

41 CFR 101-42.1102-8 - United States Munitions List items which require demilitarization.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true United States Munitions... States Munitions List items which require demilitarization. (a) General. The United States Munitions List... appropriate code assigned to each Munitions List Item (MLI) to describe what, if any, restrictions or actual...

41 CFR 101-42.1102-8 - United States Munitions List items which require demilitarization.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false United States Munitions... States Munitions List items which require demilitarization. (a) General. The United States Munitions List... appropriate code assigned to each Munitions List Item (MLI) to describe what, if any, restrictions or actual...

41 CFR 101-42.1102-8 - United States Munitions List items which require demilitarization.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 2 2011-07-01 2007-07-01 true United States Munitions... States Munitions List items which require demilitarization. (a) General. The United States Munitions List... appropriate code assigned to each Munitions List Item (MLI) to describe what, if any, restrictions or actual...

41 CFR 101-42.1102-8 - United States Munitions List items which require demilitarization.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true United States Munitions... States Munitions List items which require demilitarization. (a) General. The United States Munitions List... appropriate code assigned to each Munitions List Item (MLI) to describe what, if any, restrictions or actual...

41 CFR 101-42.1102-8 - United States Munitions List items which require demilitarization.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 2 2013-07-01 2012-07-01 true United States Munitions... States Munitions List items which require demilitarization. (a) General. The United States Munitions List... appropriate code assigned to each Munitions List Item (MLI) to describe what, if any, restrictions or actual...

1 CFR 8.1 - Policy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of the...

1 CFR 8.1 - Policy.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 1 General Provisions 1 2011-01-01 2011-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of the...

75 FR 67386 - Policy for Banning of Foreign Vessels From Entry into United States Ports

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... company management and continuous improvement are two fundamental objectives of an effective SMS... International Maritime Organization (IMO) Resolution A.741 (18), titled ``International Management Code for the Safe Operation of Ships and for Pollution Prevention (International Safe Management [ISM] Code)''. The...

47 CFR 87.199 - Special requirements for 406.0-406.1 MHz ELTs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... identification code, issued by the National Oceanic and Atmospheric Administration (NOAA), the United States... code addressed to: NOAA/SARSAT Beacon Registration, E/SP3, Federal Building 4, Room 3320, 5200 Auth..., type of aircraft, alternate emergency contact, and other information as required by NOAA. The...

47 CFR 87.199 - Special requirements for 406.0-406.1 MHz ELTs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... identification code, issued by the National Oceanic and Atmospheric Administration (NOAA), the United States... code addressed to: NOAA/SARSAT Beacon Registration, E/SP3, Federal Building 4, Room 3320, 5200 Auth..., type of aircraft, alternate emergency contact, and other information as required by NOAA. The...

The Code Noir: Construction of Slavery in French Colonial Louisiana.

ERIC Educational Resources Information Center

Arlyck, Kevin

2003-01-01

Presents a lesson focusing on the history of slavery. Compares two systems of slavery in North America to teach students about slavery within and outside of the United States. States that the lesson uses the "Code Noir" to help students understand the similarities and differences between the systems. (CMK)

21 CFR 11.300 - Controls for identification codes/passwords.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Controls for identification codes/passwords. 11.300 Section 11.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... attempts at their unauthorized use to the system security unit, and, as appropriate, to organizational...

21 CFR 11.300 - Controls for identification codes/passwords.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Controls for identification codes/passwords. 11.300 Section 11.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... attempts at their unauthorized use to the system security unit, and, as appropriate, to organizational...

40 CFR 62.14104 - Requirements for municipal waste combustor operating practices.

Code of Federal Regulations, 2013 CFR

2013-07-01

...), proceed in accordance with ASME PTC 4.1-1964 (Reaffirmed 1991), Power Test Codes: Test Code for Steam Generating Units (with 1968 and 1969 Addenda). For design, construction, installation, calibration, and use... Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You may...

40 CFR 62.14104 - Requirements for municipal waste combustor operating practices.

Code of Federal Regulations, 2014 CFR

2014-07-01

...), proceed in accordance with ASME PTC 4.1-1964 (Reaffirmed 1991), Power Test Codes: Test Code for Steam Generating Units (with 1968 and 1969 Addenda). For design, construction, installation, calibration, and use... Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You may...

40 CFR 62.14104 - Requirements for municipal waste combustor operating practices.

Code of Federal Regulations, 2010 CFR

2010-07-01

...), proceed in accordance with ASME PTC 4.1-1964 (Reaffirmed 1991), Power Test Codes: Test Code for Steam Generating Units (with 1968 and 1969 Addenda). For design, construction, installation, calibration, and use... Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You may...

40 CFR 62.14104 - Requirements for municipal waste combustor operating practices.

Code of Federal Regulations, 2012 CFR

2012-07-01

...), proceed in accordance with ASME PTC 4.1-1964 (Reaffirmed 1991), Power Test Codes: Test Code for Steam Generating Units (with 1968 and 1969 Addenda). For design, construction, installation, calibration, and use... Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You may...

40 CFR 62.14104 - Requirements for municipal waste combustor operating practices.

Code of Federal Regulations, 2011 CFR

2011-07-01

...), proceed in accordance with ASME PTC 4.1-1964 (Reaffirmed 1991), Power Test Codes: Test Code for Steam Generating Units (with 1968 and 1969 Addenda). For design, construction, installation, calibration, and use... Mechanical Engineers, Service Center, 22 Law Drive, Post Office Box 2900, Fairfield, NJ 07007. You may...

Trends in Gastroenteritis-associated Mortality in the United States 1985-2005: Variations by ICD-9 and ICD-10 Codes

EPA Science Inventory

BackgroundTrends in gastroenteritis-associated mortality are changing over time with development of antibiotic resistant strains of certain pathogens, improved diagnostic methods, and changing healthcare. In 1999, ICD-10 coding was introduced for mortality records which can also ...

40 CFR 51.166 - Prevention of significant deterioration of air quality.

Code of Federal Regulations, 2014 CFR

2014-07-01

... pollutant: Fossil fuel-fired steam electric plants of more than 250 million British thermal units per hour... ethanol by natural fermentation included in NAICS codes 325193 or 312140), fossil-fuel boilers (or... that produce ethanol by natural fermentation included in NAICS codes 325193 or 312140; (u) Fossil-fuel...

40 CFR 51.166 - Prevention of significant deterioration of air quality.

Code of Federal Regulations, 2012 CFR

2012-07-01

... pollutant: Fossil fuel-fired steam electric plants of more than 250 million British thermal units per hour... ethanol by natural fermentation included in NAICS codes 325193 or 312140), fossil-fuel boilers (or... that produce ethanol by natural fermentation included in NAICS codes 325193 or 312140; (u) Fossil-fuel...

40 CFR 51.166 - Prevention of significant deterioration of air quality.

Code of Federal Regulations, 2013 CFR

2013-07-01

... pollutant: Fossil fuel-fired steam electric plants of more than 250 million British thermal units per hour... ethanol by natural fermentation included in NAICS codes 325193 or 312140), fossil-fuel boilers (or... that produce ethanol by natural fermentation included in NAICS codes 325193 or 312140; (u) Fossil-fuel...

40 CFR 51.166 - Prevention of significant deterioration of air quality.

Code of Federal Regulations, 2011 CFR

2011-07-01

... pollutant: Fossil fuel-fired steam electric plants of more than 250 million British thermal units per hour... ethanol by natural fermentation included in NAICS codes 325193 or 312140), fossil-fuel boilers (or... that produce ethanol by natural fermentation included in NAICS codes 325193 or 312140; (u) Fossil-fuel...

To make improvements in the enactment of title 41, United States Code, into a positive law title and to improve the Code.

THOMAS, 112th Congress

Rep. Smith, Lamar [R-TX-21

2012-07-09

Senate - 09/12/2012 Received in the Senate and Read twice and referred to the Committee on the Judiciary. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

45 CFR 162.103 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... definitions apply: Code set means any set of codes used to encode data elements, such as tables of terms... sets inherent to a transaction, and not related to the format of the transaction. Data elements that... information in a transaction. Data set means a semantically meaningful unit of information exchanged between...

40 CFR 51.50 - What definitions apply to this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

... organization transmitting the data set, including first name, middle name or initial, and surname. Contact... unit's nameplate by the manufacturer. The data element is reported in megawatts or kilowatts. Method accuracy description (MAD) codes means a set of six codes used to define the accuracy of latitude/longitude...

45 CFR 162.103 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... definitions apply: Code set means any set of codes used to encode data elements, such as tables of terms... sets inherent to a transaction, and not related to the format of the transaction. Data elements that... information in a transaction. Data set means a semantically meaningful unit of information exchanged between...

45 CFR 162.103 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... definitions apply: Code set means any set of codes used to encode data elements, such as tables of terms... sets inherent to a transaction, and not related to the format of the transaction. Data elements that... information in a transaction. Data set means a semantically meaningful unit of information exchanged between...

40 CFR 51.50 - What definitions apply to this subpart?

Code of Federal Regulations, 2014 CFR

2014-07-01

... organization transmitting the data set, including first name, middle name or initial, and surname. Contact... unit's nameplate by the manufacturer. The data element is reported in megawatts or kilowatts. Method accuracy description (MAD) codes means a set of six codes used to define the accuracy of latitude/longitude...

40 CFR 51.50 - What definitions apply to this subpart?

Code of Federal Regulations, 2013 CFR

2013-07-01

... organization transmitting the data set, including first name, middle name or initial, and surname. Contact... unit's nameplate by the manufacturer. The data element is reported in megawatts or kilowatts. Method accuracy description (MAD) codes means a set of six codes used to define the accuracy of latitude/longitude...

40 CFR 51.50 - What definitions apply to this subpart?

Code of Federal Regulations, 2012 CFR

2012-07-01

... organization transmitting the data set, including first name, middle name or initial, and surname. Contact... unit's nameplate by the manufacturer. The data element is reported in megawatts or kilowatts. Method accuracy description (MAD) codes means a set of six codes used to define the accuracy of latitude/longitude...

Cataloguing and Classification Section. Bibliographic Control Division. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on cataloging, classification, and coding systems which were presented at the 1982 International Federation of Library Associations (IFLA) conference include: (1) "Numbering and Coding Systems for Bibliographic Control in Use in North America" by Lois Mai Chan (United States); (2) "A Project Undertaken by the Library of…

Studies of Heat Transfer in Complex Internal Flows.

DTIC Science & Technology

1982-01-01

D.C. 20362 (Tel 202-692-6874) Mr. Richard S. Carlton Director, Engines Division, Code 523 NC #4 Naval Sea Systems Command Washington, D.C. 20362...Walter Ritz Code 033C Naval Ships Systems Engineering Station Philadelphia, Pennsylvania 19112 (Tel. 215-755-3841) Dr. Simion Kuo United Tech. Res

1 CFR 8.6 - Forms of publication.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Forms of publication. 8.6 Section 8.6 General... FEDERAL REGULATIONS § 8.6 Forms of publication. (a) Under section 1506 of title 44, United States Code, the Administrative Committee authorizes publication of the Code of Federal Regulations in the...

1 CFR 8.6 - Forms of publication.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true Forms of publication. 8.6 Section 8.6 General... FEDERAL REGULATIONS § 8.6 Forms of publication. (a) Under section 1506 of title 44, United States Code, the Administrative Committee authorizes publication of the Code of Federal Regulations in the...

1 CFR 8.1 - Policy.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 1 General Provisions 1 2013-01-01 2012-01-01 true Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of the...

1 CFR 8.1 - Policy.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 1 General Provisions 1 2012-01-01 2012-01-01 false Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of the...

1 CFR 8.1 - Policy.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 1 General Provisions 1 2014-01-01 2012-01-01 true Policy. 8.1 Section 8.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER CODE OF FEDERAL REGULATIONS § 8.1 Policy. (a) Pursuant to chapter 15 of title 44, United States Code, the Director of the...

Collision count in rugby union: A comparison of micro-technology and video analysis methods.

PubMed

Reardon, Cillian; Tobin, Daniel P; Tierney, Peter; Delahunt, Eamonn

2017-10-01

The aim of our study was to determine if there is a role for manipulation of g force thresholds acquired via micro-technology for accurately detecting collisions in rugby union. In total, 36 players were recruited from an elite Guinness Pro12 rugby union team. Player movement profiles and collisions were acquired via individual global positioning system (GPS) micro-technology units. Players were assigned to a sub-category of positions in order to determine positional collision demands. The coding of collisions by micro-technology at g force thresholds between 2 and 5.5 g (0.5 g increments) was compared with collision coding by an expert video analyst using Bland-Altman assessments. The most appropriate g force threshold (smallest mean difference compared with video analyst coding) was lower for all forwards positions (2.5 g) than for all backs positions (3.5 g). The Bland-Altman 95% limits of agreement indicated that there may be a substantial over- or underestimation of collisions coded via GPS micro-technology when using expert video analyst coding as the reference comparator. The manipulation of the g force thresholds applied to data acquired by GPS micro-technology units based on incremental thresholds of 0.5 g does not provide a reliable tool for the accurate coding of collisions in rugby union. Future research should aim to investigate smaller g force threshold increments and determine the events that cause coding of false positives.

Real-Space Density Functional Theory on Graphical Processing Units: Computational Approach and Comparison to Gaussian Basis Set Methods.

PubMed

Andrade, Xavier; Aspuru-Guzik, Alán

2013-10-08

We discuss the application of graphical processing units (GPUs) to accelerate real-space density functional theory (DFT) calculations. To make our implementation efficient, we have developed a scheme to expose the data parallelism available in the DFT approach; this is applied to the different procedures required for a real-space DFT calculation. We present results for current-generation GPUs from AMD and Nvidia, which show that our scheme, implemented in the free code Octopus, can reach a sustained performance of up to 90 GFlops for a single GPU, representing a significant speed-up when compared to the CPU version of the code. Moreover, for some systems, our implementation can outperform a GPU Gaussian basis set code, showing that the real-space approach is a competitive alternative for DFT simulations on GPUs.

Development of a 14-digit Hydrologic Unit Code Numbering System for South Carolina

USGS Publications Warehouse

Bower, David E.; Lowry, Claude; Lowery, Mark A.; Hurley, Noel M.

1999-01-01

A Hydrologic Unit Map showing the cataloging units, watersheds, and subwatersheds of South Carolina has been developed by the U.S. Geological Survey in cooperation with the South Carolina Department of Health and Environmental Control, funded through a U.S. Environmental Protection Agency 319 Grant, and the U.S. Department of Agriculture, Natural Resources Conservation Service. These delineations represent 8-, 11-, and 14-digit Hydrologic Unit Codes, respectively. This map presents information on drainage, hydrography, and hydrologic boundaries of the water-resources regions, subregions, accounting units, cataloging units, watersheds, and subwatersheds. The source maps for the basin delineations are 1:24,000-scale 7.5-minute series topographic maps and the base maps are from 1:100,000-scale Digital Line Graphs; however, the data are published at a scale of 1:500,000. In addition, an electronic version of the data is provided on a compact disc.Of the 1,022 subwatersheds delineated for this project, 1,004 range in size from 3,000 to 40,000 acres (4.69 to 62.5 square miles). Seventeen subwatersheds are smaller than 3,000 acres and one subwatershed, located on St. Helena Island, is larger than 40,000 acres.This map and its associated codes provide a standardized base for use by water-resource managers and planners in locating, storing, retrieving, and exchanging hydrologic data. In addition, the map can be used for cataloging water-data acquisition activities, geographically organizing hydrologic data, and planning and describing water-use and related land-use activities.

26 CFR 1.987-5 - Transition rules for certain qualified business units using a profit and loss method of...

Code of Federal Regulations, 2010 CFR

2010-04-01

... of United States persons that have a nondollar functional currency and that used a net worth method...) branches of United States persons, whose functional currency (as defined in section 985 of the Code and the regulations thereunder) is other than the United States dollar (dollar) and that used a profit and loss method...

Nellis Air Force Base Capital Improvements Program Environmental Assessment

DTIC Science & Technology

2013-08-01

Air Force Warfare Center USC United States Code USCB United States Census Bureau USFWS United States Fish and Wildlife Service VOC Volatile...project arise with the potential to affect desert tortoise, consultation with the United States (U.S.) Fish and Wildlife Service would be initiated...Environmental Design (LEED) facilities and decrease energy consumption on military installations. The projects described in the CIP are derived

Installation Development Environmental Assessment Travis Air Force Base, California

DTIC Science & Technology

2007-11-01

United States Code USEPA United States Environmental Protection Agency USFWS United States Fish and Wildlife Service USGS United States...kilometers) north to south, its northern half referred to as the Sacramento Valley and its southern half as the San Joaquin Valley . This area is...Sacramento and San Joaquin Rivers, fans and floodplains of tributary streams, and terraces and foothills around the edge of the valleys . Elevation

Buen Viaje: Mutually Beneficial Tourism. A Four-Lesson Unit about Traveling with Care in Mexico for Grades 8-12 and Adult Learners in English and Spanish.

ERIC Educational Resources Information Center

Mattson, Alexandra; Ruiz, Octavio; Sommers, Meredith

Intended for secondary students, this curriculum unit (in both English and Spanish) provides a look into Mexico's second largest industry, tourism. The curriculum unit of four lessons includes general information about tourism, maps, stories, and a code of behavior for travelers. The unit enumerates learner objectives, defines vocabulary and…

Spacelab interface development test, volume 1, sections 1-6

NASA Technical Reports Server (NTRS)

Harris, L. H.

1979-01-01

Data recorded during the following tests is presented: pulse coded modulator master unit to Spacelab (S/L) interface, master timing unit to S/L interface, multiplexer-demultiplexer/serial input-output to S/L interface, and special tests.

Medical Surveillance Monthly Report (MSMR). Volume 6, Number 3, March 2000

DTIC Science & Technology

2000-03-01

Rocky Mountain spotted fever (RMSF), are more common in temperate regions such as the United States...0.2 1. Through September 30, 1999. Characteristics N Rate2 Malaria Rocky Mountain Spotted Fever Rate2NRate2 Lyme disease 3. IAW DoD Occupational...085.9); Lyme disease (ICD-9-CM code: 088.81); dengue fever (ICD-9-CM code: 061); or Rocky Mountain spotted fever (ICD-9-CM code: 082.0). If an

Verifying the Chemical Weapons Convention: The Case for a United Nations Verification Agency

DTIC Science & Technology

1991-12-01

ORGANIZATION REPORT NUMBER(S) 6&. NAME OF PERFORMING ORGANIZATION j6b. OFFICE SYMBOL 7&. NAME OF MONITORING ORGANIZATION Naval Postgraduate School J(if applicaip...Naval Postgraduate School 6c. ADDRESS (City, State, and ZIP Code) 7b. ADDRESS (City, State, and ZIP Code) Monterey. CA 93943-5000 Monterey, CA 93943...Governinent. 17. COSATI CODES 18. SUBJECT TERMS (continue on reverse if necessaty and identify by black number) -FIELD GROUP SUBGROUP Chemical

County-based estimates of nitrogen and phosphorus content of animal manure in the United States for 1982, 1987, and 1992

USGS Publications Warehouse

Puckett, Larry; Hitt, Kerie; Alexander, Richard

1998-01-01

names that correspond to the FIPS codes. 2. Tabular component - Nine tab-delimited ASCII lookup tables of animal counts and nutrient estimates organized by 5-digit state/county FIPS (Federal Information Processing Standards) code. Another table lists the county names that correspond to the FIPS codes. The use of trade names is for identification purposes only and does not constitute endorsement by the U.S. Geological Survey.

Simulated effects of alternative withdrawal strategies on groundwater flow in the unconfined Kirkwood-Cohansey aquifer system, the Rio Grande water-bearing zone, and the Atlantic City 800-foot sand in the Great Egg Harbor and Mullica River Basins, New Jersey

USGS Publications Warehouse

Pope, Daryll A.; Carleton, Glen B.; Buxton, Debra E.; Walker, Richard L.; Shourds, Jennifer L.; Reilly, Pamela A.

2012-01-01

Groundwater is essential for water supply and plays a critical role in maintaining the environmental health of freshwater and estuarine ecosystems in the Atlantic Coastal basins of New Jersey. The unconfined Kirkwood-Cohansey aquifer system and the confined Atlantic City 800-foot sand are major sources of groundwater in the area, and each faces different water-supply concerns. The U.S. Geological Survey (USGS), in cooperation with the New Jersey Department of Environmental Protection (NJDEP), conducted a study to simulate the effects of withdrawals in the Kirkwood-Cohansey aquifer system, the Atlantic City 800-foot sand, and the Rio Grande water-bearing zone and to evaluate potential scenarios. The study area encompasses Atlantic County and parts of Burlington, Camden, Gloucester, Ocean, Cape May, and Cumberland Counties. The major hydrogeologic units affecting water supply in the study area are the surficial Kirkwood-Cohansey aquifer system, a thick diatomaceous clay confining unit in the upper part of Kirkwood Formation; the Rio Grande water-bearing zone; and the Atlantic City 800-foot sand of the Kirkwood Formation. Hydrogeologic data from 18 aquifer tests and specific capacity data from 230 wells were analyzed to provide horizontal hydraulic conductivity of the aquifers. Groundwater withdrawals are greatest from the Kirkwood-Cohansey aquifer system, and 65 percent of the water is used for public supply. Groundwater withdrawals from the Atlantic City 800-foot sand are about half those from the Kirkwood-Cohansey aquifer system. Ninety-five percent of the withdrawals from the Atlantic City 800-foot sand is used for public supply. Data from six streamgaging stations and 51 low-flow partial record sites were used to estimate base flow in the area. Base flow ranges from 60 to 92 percent of streamflow. A groundwater flow model of the Kirkwood-Cohansey aquifer system, the Rio Grande water-bearing zone, and the Atlantic City 800-foot sand was developed and calibrated using water-level data from 148 wells and base-flow data from 22 gaging or low-flow partial record stations. The Kirkwood-Cohansey aquifer system within the Great Egg Harbor River and the Mullica River Basins was simulated on a monthly basis from 1998 through 2006. An existing regional model of the New Jersey Coastal Plain was revised to provide boundary conditions for the Great Egg Harbor and Mullica River Basin model (referred to as the Great Egg-Mullica model). In the Great Egg-Mullica model, monthly groundwater recharge rates used in the model ranged from 10-15 inches per year in 2001 to 20-25 inches per year in 2005. The mean-absolute error for 10 of the 14 long-term hydrographs used in model calibration was less than 5 ft. Groundwater flow budgets for the Great Egg-Mullica model calibration periods, May 2005 and September 2006, and for the entire model calibration period 1998 to 2006, showed that nearly 70 percent of the water entering the Atlantic City 800-foot sand came from the horizontal connection with the Kirkwood-Cohansey aquifer system in updip areas. The groundwater flow model was used to simulate scenarios under three possible conditions: average 1998 to 2006 withdrawals (Average scenario), full-allocation withdrawals (Full Allocation scenario), and projected 2050-demand withdrawals (2050 Demand scenario). Withdrawals in the Full Allocation scenario are nearly twice the withdrawals from the Average scenario, primarily because of the potential for large agricultural withdrawals if all allocations are used. Withdrawals for the 2050 Demand scenario are about 50 percent greater than those for the Average scenario, primarily due to expected increases in withdrawals for public supply. Monthly base-flow depletion criteria were determined using the Low-Flow Margin method, currently under consideration by NJDEP, to estimate available water on an annual basis at the Hydrologic Unit Code 11 (HUC11) level and to determine whether a water-supply deficit exists. Simulations of various groundwater-withdrawal scenarios were made using the calibrated model, and results were compared with baseline conditions (no withdrawals) to determine where and when base-flow deficits may be occurring and may be expected to occur in the future. Scenarios were simulated to assess base-flow depletion that could occur from different groundwater-withdrawal situations. In the Average scenario, deficits occurred in 7 of the 14 subbasins. In the Full Allocation scenario, deficits occurred in 11 of the subbasins. In the 2050 Demand scenario, deficits occurred in 9 of the 14 subbasins. The largest deficits occurred in the Absecon Creek subbasin because the base-flow depletion criteria for this subbasin is small due to the surface-water diversions that are already occurring there and because existing groundwater withdrawals in the subbasin have resulted in base-flow depletion under current (1998-2006) conditions. Three adjusted scenarios, variations of the Average, Full Allocation, and 2050 Demand scenarios, were simulated; for the adjusted scenarios, the withdrawals were modified in stages with the intent to successively eliminate or minimize the base-flow deficits. Modifications included shifting withdrawals to a deeper part of the Kirkwood-Cohansey aquifer system, implementing seasonal conjunctive use of shallow and deep aquifers, and specifying reductions in withdrawals within a HUC11 subbasin in deficit. The adjusted scenarios are intended to show the relative effectiveness of each of the three approaches in reducing the deficits. Most of the deficits under the Average, Full Allocation, and 2050 Demand scenarios were eliminated by reductions in withdrawals or allocations. Shifting withdrawals to a deeper part of the Kirkwood-Cohansey aquifer system or seasonal conjunctive use did not eliminate deficits for any subbasin. Reductions in withdrawals accounted for more than 95 percent of the total reduction of deficits in all but one subbasin.

The presence of social support messages on YouTube videos about inflammatory bowel disease and ostomies.

PubMed

Frohlich, Dennis Owen; Zmyslinski-Seelig, Anne

2012-01-01

The purpose of this study was to explore the types of social support messages YouTube users posted on medical videos. Specifically, the study compared messages posted on inflammatory bowel disease-related videos and ostomy-related videos. Additionally, the study analyzed the differences in social support messages posted on lay-created videos and professionally-created videos. Conducting a content analysis, the researchers unitized the comments on each video; the total number of thought units amounted to 5,960. Researchers coded each thought unit through the use of a coding scheme modified from a previous study. YouTube users posted informational support messages most frequently (65.1%), followed by emotional support messages (18.3%), and finally, instrumental support messages (8.2%).

Opcode counting for performance measurement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gara, Alan; Satterfield, David L.; Walkup, Robert E.

Methods, systems and computer program products are disclosed for measuring a performance of a program running on a processing unit of a processing system. In one embodiment, the method comprises informing a logic unit of each instruction in the program that is executed by the processing unit, assigning a weight to each instruction, assigning the instructions to a plurality of groups, and analyzing the plurality of groups to measure one or more metrics. In one embodiment, each instruction includes an operating code portion, and the assigning includes assigning the instructions to the groups based on the operating code portions ofmore » the instructions. In an embodiment, each type of instruction is assigned to a respective one of the plurality of groups. These groups may be combined into a plurality of sets of the groups.« less

The Relative Value Unit: History, Current Use, and Controversies.

PubMed

Baadh, Amanjit; Peterkin, Yuri; Wegener, Melanie; Flug, Jonathan; Katz, Douglas; Hoffmann, Jason C

2016-01-01

The relative value unit (RVU) is an important measuring tool for the work performed by physicians, and is currently used in the United States to calculate physician reimbursement. An understanding of radiology RVUs and current procedural terminology codes is important for radiologists, trainees, radiology managers, and administrators, as this knowledge would help them to understand better their current productivity and reimbursement, as well as controversies regarding reimbursement, and permit them to adapt to reimbursement changes that may occur in the future. This article reviews the components of the RVU and how radiology payment is calculated, highlights trends in RVUs and resultant payment for diagnostic and therapeutic imaging and examinations, and discusses current issues involving RVU and current procedural terminology codes. Copyright © 2015 Mosby, Inc. All rights reserved.

Opcode counting for performance measurement

DOEpatents

Gara, Alan; Satterfield, David L; Walkup, Robert E

2013-10-29

Methods, systems and computer program products are disclosed for measuring a performance of a program running on a processing unit of a processing system. In one embodiment, the method comprises informing a logic unit of each instruction in the program that is executed by the processing unit, assigning a weight to each instruction, assigning the instructions to a plurality of groups, and analyzing the plurality of groups to measure one or more metrics. In one embodiment, each instruction includes an operating code portion, and the assigning includes assigning the instructions to the groups based on the operating code portions of the instructions. In an embodiment, each type of instruction is assigned to a respective one of the plurality of groups. These groups may be combined into a plurality of sets of the groups.

Opcode counting for performance measurement

DOEpatents

Gara, Alan; Satterfield, David L.; Walkup, Robert E.

2015-08-11

Methods, systems and computer program products are disclosed for measuring a performance of a program running on a processing unit of a processing system. In one embodiment, the method comprises informing a logic unit of each instruction in the program that is executed by the processing unit, assigning a weight to each instruction, assigning the instructions to a plurality of groups, and analyzing the plurality of groups to measure one or more metrics. In one embodiment, each instruction includes an operating code portion, and the assigning includes assigning the instructions to the groups based on the operating code portions of the instructions. In an embodiment, each type of instruction is assigned to a respective one of the plurality of groups. These groups may be combined into a plurality of sets of the groups.

Opcode counting for performance measurement

DOEpatents

Gara, Alan; Satterfield, David L.; Walkup, Robert E.

2016-10-18

Methods, systems and computer program products are disclosed for measuring a performance of a program running on a processing unit of a processing system. In one embodiment, the method comprises informing a logic unit of each instruction in the program that is executed by the processing unit, assigning a weight to each instruction, assigning the instructions to a plurality of groups, and analyzing the plurality of groups to measure one or more metrics. In one embodiment, each instruction includes an operating code portion, and the assigning includes assigning the instructions to the groups based on the operating code portions of the instructions. In an embodiment, each type of instruction is assigned to a respective one of the plurality of groups. These groups may be combined into a plurality of sets of the groups.

26 CFR 1.959-4 - Distributions to United States persons not counting as dividends.

Code of Federal Regulations, 2010 CFR

2010-04-01

... normal taxes and surtaxes) of subtitle A (relating to income taxes) of the Code as a distribution which... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Distributions to United States persons not... Distributions to United States persons not counting as dividends. Except as provided in section 960(a)(3) and...

76 FR 31991 - All Items Consumer Price Index for All Urban Consumers; United States City Average

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

... DEPARTMENT OF LABOR Office of the Secretary All Items Consumer Price Index for All Urban Consumers; United States City Average Pursuant to Section 33105(c) of Title 49, United States Code, and the... Consumer Price Index for All Urban Consumers (1967 = 100) increased 110.0 percent from its 1984 annual...

77 FR 23283 - All Items Consumer Price Index for All Urban Consumers; United States City Average

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... DEPARTMENT OF LABOR Office of the Secretary All Items Consumer Price Index for All Urban Consumers; United States City Average Pursuant to Section 33105(c) of Title 49, United States Code, and the... Consumer Price Index for All Urban Consumers (1967 = 100) increased 116.6 percent from its 1984 annual...

48 CFR 52.204-16 - Commercial and Government Entity Code Reporting.

Code of Federal Regulations, 2014 CFR

2014-10-01

... assigned to entities located in the United States or its outlying areas by the Defense Logistics Agency... NATO Support Agency (NSPA) to entities located outside the United States and its outlying areas that... www.sam.gov. If the Offeror is located in the United States or its outlying areas and does not already...

Continuous Codes and Standards Improvement (CCSI)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rivkin, Carl H; Burgess, Robert M; Buttner, William J

2015-10-21

As of 2014, the majority of the codes and standards required to initially deploy hydrogen technologies infrastructure in the United States have been promulgated. These codes and standards will be field tested through their application to actual hydrogen technologies projects. Continuous codes and standards improvement (CCSI) is a process of identifying code issues that arise during project deployment and then developing codes solutions to these issues. These solutions would typically be proposed amendments to codes and standards. The process is continuous because as technology and the state of safety knowledge develops there will be a need to monitor the applicationmore » of codes and standards and improve them based on information gathered during their application. This paper will discuss code issues that have surfaced through hydrogen technologies infrastructure project deployment and potential code changes that would address these issues. The issues that this paper will address include (1) setback distances for bulk hydrogen storage, (2) code mandated hazard analyses, (3) sensor placement and communication, (4) the use of approved equipment, and (5) system monitoring and maintenance requirements.« less

Welding.

ERIC Educational Resources Information Center

Cowan, Earl; And Others

The curriculum guide for welding instruction contains 16 units presented in six sections. Each unit is divided into the following areas, each of which is color coded: terminal objectives, specific objectives, suggested activities, and instructional materials; information sheet; transparency masters; assignment sheet; test; and test answers. The…

76 FR 77563 - Florida Power & Light Company; St. Lucie Plant, Unit No. 1; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-13

....2, because the P-T limits developed for St. Lucie, Unit 1, use a finite element method to determine... Code for calculating K Im factors, and instead applies FEM [finite element modeling] methods for...

39 CFR 3050.24 - Documentation supporting estimates of costs avoided by worksharing and other mail characteristics...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Computer Reader finalization costs, cost per image, and Remote Bar Code Sorter leakage; (8) Percentage of... processing units costs for Carrier Route, High Density, and Saturation mail; (j) Mail processing unit costs...

39 CFR 3050.24 - Documentation supporting estimates of costs avoided by worksharing and other mail characteristics...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Computer Reader finalization costs, cost per image, and Remote Bar Code Sorter leakage; (8) Percentage of... processing units costs for Carrier Route, High Density, and Saturation mail; (j) Mail processing unit costs...

39 CFR 3050.24 - Documentation supporting estimates of costs avoided by worksharing and other mail characteristics...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Computer Reader finalization costs, cost per image, and Remote Bar Code Sorter leakage; (8) Percentage of... processing units costs for Carrier Route, High Density, and Saturation mail; (j) Mail processing unit costs...

39 CFR 3050.24 - Documentation supporting estimates of costs avoided by worksharing and other mail characteristics...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Computer Reader finalization costs, cost per image, and Remote Bar Code Sorter leakage; (8) Percentage of... processing units costs for Carrier Route, High Density, and Saturation mail; (j) Mail processing unit costs...

39 CFR 3050.24 - Documentation supporting estimates of costs avoided by worksharing and other mail characteristics...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Computer Reader finalization costs, cost per image, and Remote Bar Code Sorter leakage; (8) Percentage of... processing units costs for Carrier Route, High Density, and Saturation mail; (j) Mail processing unit costs...

30 CFR 250.1495 - How do I demonstrate financial solvency?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 99503-5823, jeffrey,[email protected], (907) 334-5300. (2) For Gulf of Mexico and Atlantic OCS: Joshua Joyce, Regional FARM Program Coordinator, BOEMRE Gulf of Mexico OCS Region, 1201 Elmwood Park Boulevard... provision of the U.S. Bankruptcy Code (Title 11 of the United States Code), or BOEMRE notifies you that you...

30 CFR 250.1495 - How do I demonstrate financial solvency?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., [email protected], (907) 334-5300. (2) For Gulf of Mexico and Atlantic OCS: Joshua Joyce, Regional FARM Program Coordinator, BOEM Gulf of Mexico OCS Region, 1201 Elmwood Park Boulevard New Orleans, LA.... Bankruptcy Code (Title 11 of the United States Code), or BSEE notifies you that you must redemonstrate...

30 CFR 250.1495 - How do I demonstrate financial solvency?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., [email protected], (907) 334-5300. (2) For Gulf of Mexico and Atlantic OCS: Joshua Joyce, Regional FARM Program Coordinator, BOEM Gulf of Mexico OCS Region, 1201 Elmwood Park Boulevard New Orleans, LA.... Bankruptcy Code (Title 11 of the United States Code), or BSEE notifies you that you must redemonstrate...

30 CFR 250.1495 - How do I demonstrate financial solvency?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., [email protected], (907) 334-5300. (2) For Gulf of Mexico and Atlantic OCS: Joshua Joyce, Regional FARM Program Coordinator, BOEM Gulf of Mexico OCS Region, 1201 Elmwood Park Boulevard New Orleans, LA.... Bankruptcy Code (Title 11 of the United States Code), or BSEE notifies you that you must redemonstrate...

26 CFR 51.4T - Information provided by the agencies (temporary).

Code of Federal Regulations, 2013 CFR

2013-04-01

... sales price (ASP) for each Healthcare Common Procedure Coding System (HCPCS) code for the sales year...IdentifiableDataFiles/03_PartBNationalSummaryDataFile.asp to obtain the number of allowed billing units per... respective NDCs) manufactured by a single entity, CMS will multiply the annual weighted ASP by the total...

26 CFR 51.4T - Information provided by the agencies (temporary).

Code of Federal Regulations, 2014 CFR

2014-04-01

... sales price (ASP) for each Healthcare Common Procedure Coding System (HCPCS) code for the sales year...IdentifiableDataFiles/03_PartBNationalSummaryDataFile.asp to obtain the number of allowed billing units per... respective NDCs) manufactured by a single entity, CMS will multiply the annual weighted ASP by the total...

26 CFR 51.4T - Information provided by the agencies (temporary).

Code of Federal Regulations, 2012 CFR

2012-04-01

... sales price (ASP) for each Healthcare Common Procedure Coding System (HCPCS) code for the sales year...IdentifiableDataFiles/03_PartBNationalSummaryDataFile.asp to obtain the number of allowed billing units per... respective NDCs) manufactured by a single entity, CMS will multiply the annual weighted ASP by the total...

Occupational Titles Including Job Descriptions for Health Occupations Education.

ERIC Educational Resources Information Center

East Texas State Univ., Commerce. Occupational Curriculum Lab.

This alphabetical compilation of 80 occupational titles for health occupations education is taken from the Dictionary of Occupational Titles, (DOT), 4th edition, 1977. An index shows the arrangement of the occupational titles (together with instructional program and DOT code) according to the United States Office of Education code numbers. For…

Health Impact Assessment (HIA) of Proposed Code Changes Regarding Onsite Sewage Disposal Systems in Suffolk County, NY

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) conducted a Health Impact Assessment (HIA) of proposed code changes regarding residential onsite sewage disposal systems (OSDS) in Suffolk County, New York. Of the approximately 569,000 housing units in Suffolk County, 365,000 are no...

A History of Instructional Methods in Uncontracted and Contracted Braille

ERIC Educational Resources Information Center

D'Andrea, Frances Mary

2009-01-01

This literature review outlines the history of the braille code as used in the United States and Canada, illustrating how both the code itself and instructional strategies for teaching it changed over time. The review sets the stage for the research questions of the recently completed Alphabetic Braille and Contracted Braille Study.

Design and construction of a 2D metal organic framework with multiple cavities: a nonregular net with a paracyclophane that codes for multiply fused nodes.

PubMed

Papaefstathiou, Giannis S; Friscić, Tomislav; MacGillivray, Leonard R

2005-10-19

A metal organic framework with two different nodes (circle and square) and a structure related to one of the 20 known 2-uniform nets has been constructed using an organic building unit that codes for multiply fused nodes.

78 FR 73568 - VTL Associates, LLC, et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-06

... from, the series in connection with the purchase and redemption of Creation Units; and (e) certain... Inside Information Policy. In accordance with the Code of Ethics \\10\\ and Inside Information Policy of... affiliate specified in Item 10. \\10\\ The Adviser has also adopted or will adopt a code of ethics pursuant to...

76 FR 7864 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

...: Psychiatric Unit Criteria Work Sheet and Supporting Regulations 412.25 and 412.27; Use: A limited number of... National Correct Coding Initiative in Medicaid, SMD Letter 10-017 dated September 1, 2010. Use; The Patient... State Use of National Correct Coding Initiative. A State Medicaid Director letter, 10-017 dated...

Associative memory of phase-coded spatiotemporal patterns in leaky Integrate and Fire networks.

PubMed

Scarpetta, Silvia; Giacco, Ferdinando

2013-04-01

We study the collective dynamics of a Leaky Integrate and Fire network in which precise relative phase relationship of spikes among neurons are stored, as attractors of the dynamics, and selectively replayed at different time scales. Using an STDP-based learning process, we store in the connectivity several phase-coded spike patterns, and we find that, depending on the excitability of the network, different working regimes are possible, with transient or persistent replay activity induced by a brief signal. We introduce an order parameter to evaluate the similarity between stored and recalled phase-coded pattern, and measure the storage capacity. Modulation of spiking thresholds during replay changes the frequency of the collective oscillation or the number of spikes per cycle, keeping preserved the phases relationship. This allows a coding scheme in which phase, rate and frequency are dissociable. Robustness with respect to noise and heterogeneity of neurons parameters is studied, showing that, since dynamics is a retrieval process, neurons preserve stable precise phase relationship among units, keeping a unique frequency of oscillation, even in noisy conditions and with heterogeneity of internal parameters of the units.

Practical Implementation of Prestack Kirchhoff Time Migration on a General Purpose Graphics Processing Unit

NASA Astrophysics Data System (ADS)

Liu, Guofeng; Li, Chun

2016-08-01

In this study, we present a practical implementation of prestack Kirchhoff time migration (PSTM) on a general purpose graphic processing unit. First, we consider the three main optimizations of the PSTM GPU code, i.e., designing a configuration based on a reasonable execution, using the texture memory for velocity interpolation, and the application of an intrinsic function in device code. This approach can achieve a speedup of nearly 45 times on a NVIDIA GTX 680 GPU compared with CPU code when a larger imaging space is used, where the PSTM output is a common reflection point that is gathered as I[ nx][ ny][ nh][ nt] in matrix format. However, this method requires more memory space so the limited imaging space cannot fully exploit the GPU sources. To overcome this problem, we designed a PSTM scheme with multi-GPUs for imaging different seismic data on different GPUs using an offset value. This process can achieve the peak speedup of GPU PSTM code and it greatly increases the efficiency of the calculations, but without changing the imaging result.

New World Health Organization guidance helps protect breastfeeding as a human right.

PubMed

Grummer-Strawn, Laurence M; Zehner, Elizabeth; Stahlhofer, Marcus; Lutter, Chessa; Clark, David; Sterken, Elisabeth; Harutyunyan, Susanna; Ransom, Elizabeth I

2017-10-01

Written by the WHO/UNICEF NetCode author group, the comment focuses on the need to protect families from promotion of breast-milk substitutes and highlights new WHO Guidance on Ending Inappropriate Promotion of Foods for Infants and Young Children. The World Health Assembly welcomed this Guidance in 2016 and has called on all countries to adopt and implement the Guidance recommendations. NetCode, the Network for Global Monitoring and Support for Implementation of the International Code of Marketing of Breast-milk Substitutes and Subsequent Relevant World Health Assembly Resolutions, is led by the World Health Organization and the United Nations Children's Fund. NetCode members include the International Baby Food Action Network, World Alliance for Breastfeeding Action, Helen Keller International, Save the Children, and the WHO Collaborating Center at Metropol University. The comment frames the issue as a human rights issue for women and children, as articulated by a statement from the United Nations Office of the High Commissioner for Human Rights. © 2017 The Authors. Maternal and Child Nutrition Published by John Wiley & Sons, Ltd.

Role Allocation and Team Structure in Command and Control Teams

DTIC Science & Technology

2014-06-01

organizational psychology and management sciences literature show concepts such as empowered self-management and self-regulating work teams (see Cooney, 2004...tankers (FT), search units (S) and rescue units (R). Each unit is represented on the map by a numbered icon. Each type of unit is colour -coded and...Understanding team adaptation: A conceptual analysis and model. Journal of Applied Psychology , 91, 1189-1207. Cannon-Bowers, J. A., Tannenbaum

An Analysis of United States Marine Corps Enlisted Entry-Level Training Using Supply Chain and Operations Management

DTIC Science & Technology

2010-12-01

An Analysis of United States Marine Corps Enlisted Entry-Level Training Using Supply Chain and Operations Management ______________________________________ By...Report 4. TITLE AND SUBTITLE: An Analysis of United States Marine Corps Enlisted Entry-Level Training Using Supply Chain and Operations Management 6...Level Training; United States Marine Corps; Operations Management ; Supply Chain Management; Process Analysis 16. PRICE CODE 17. SECURITY

Comparing Methods for Estimating Direct Costs of Adverse Drug Events.

PubMed

Gyllensten, Hanna; Jönsson, Anna K; Hakkarainen, Katja M; Svensson, Staffan; Hägg, Staffan; Rehnberg, Clas

2017-12-01

To estimate how direct health care costs resulting from adverse drug events (ADEs) and cost distribution are affected by methodological decisions regarding identification of ADEs, assigning relevant resource use to ADEs, and estimating costs for the assigned resources. ADEs were identified from medical records and diagnostic codes for a random sample of 4970 Swedish adults during a 3-month study period in 2008 and were assessed for causality. Results were compared for five cost evaluation methods, including different methods for identifying ADEs, assigning resource use to ADEs, and for estimating costs for the assigned resources (resource use method, proportion of registered cost method, unit cost method, diagnostic code method, and main diagnosis method). Different levels of causality for ADEs and ADEs' contribution to health care resource use were considered. Using the five methods, the maximum estimated overall direct health care costs resulting from ADEs ranged from Sk10,000 (Sk = Swedish krona; ~€1,500 in 2016 values) using the diagnostic code method to more than Sk3,000,000 (~€414,000) using the unit cost method in our study population. The most conservative definitions for ADEs' contribution to health care resource use and the causality of ADEs resulted in average costs per patient ranging from Sk0 using the diagnostic code method to Sk4066 (~€500) using the unit cost method. The estimated costs resulting from ADEs varied considerably depending on the methodological choices. The results indicate that costs for ADEs need to be identified through medical record review and by using detailed unit cost data. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Metrics and tools for consistent cohort discovery and financial analyses post-transition to ICD-10-CM

PubMed Central

Boyd, Andrew D; ‘John’ Li, Jianrong; Kenost, Colleen; Joese, Binoy; Min Yang, Young; Kalagidis, Olympia A; Zenku, Ilir; Saner, Donald; Bahroos, Neil; Lussier, Yves A

2015-01-01

In the United States, International Classification of Disease Clinical Modification (ICD-9-CM, the ninth revision) diagnosis codes are commonly used to identify patient cohorts and to conduct financial analyses related to disease. In October 2015, the healthcare system of the United States will transition to ICD-10-CM (the tenth revision) diagnosis codes. One challenge posed to clinical researchers and other analysts is conducting diagnosis-related queries across datasets containing both coding schemes. Further, healthcare administrators will manage growth, trends, and strategic planning with these dually-coded datasets. The majority of the ICD-9-CM to ICD-10-CM translations are complex and nonreciprocal, creating convoluted representations and meanings. Similarly, mapping back from ICD-10-CM to ICD-9-CM is equally complex, yet different from mapping forward, as relationships are likewise nonreciprocal. Indeed, 10 of the 21 top clinical categories are complex as 78% of their diagnosis codes are labeled as “convoluted” by our analyses. Analysis and research related to external causes of morbidity, injury, and poisoning will face the greatest challenges due to 41 745 (90%) convolutions and a decrease in the number of codes. We created a web portal tool and translation tables to list all ICD-9-CM diagnosis codes related to the specific input of ICD-10-CM diagnosis codes and their level of complexity: “identity” (reciprocal), “class-to-subclass,” “subclass-to-class,” “convoluted,” or “no mapping.” These tools provide guidance on ambiguous and complex translations to reveal where reports or analyses may be challenging to impossible. Web portal: http://www.lussierlab.org/transition-to-ICD9CM/ Tables annotated with levels of translation complexity: http://www.lussierlab.org/publications/ICD10to9 PMID:25681260

CrossTalk, The Journal of Defense Software Engineering. Volume 27, Number 4. July/August 2014

DTIC Science & Technology

2014-07-01

hires him for the work.” To do this with a development project, isolate parts of the sys- tem the development of which is not obvious and develop...class. Coupling makes it more difficult to isolate units of code for testing. The interdependence also makes code comprehension more difficult and...coupled, it is more difficult or impossible to isolate the module under test to ensure the test is focusing only on the desired code and producing

Connection anonymity analysis in coded-WDM PONs

NASA Astrophysics Data System (ADS)

Sue, Chuan-Ching

2008-04-01

A coded wavelength division multiplexing passive optical network (WDM PON) is presented for fiber to the home (FTTH) systems to protect against eavesdropping. The proposed scheme applies spectral amplitude coding (SAC) with a unipolar maximal-length sequence (M-sequence) code matrix to generate a specific signature address (coding) and to retrieve its matching address codeword (decoding) by exploiting the cyclic properties inherent in array waveguide grating (AWG) routers. In addition to ensuring the confidentiality of user data, the proposed coded-WDM scheme is also a suitable candidate for the physical layer with connection anonymity. Under the assumption that the eavesdropper applies a photo-detection strategy, it is shown that the coded WDM PON outperforms the conventional TDM PON and WDM PON schemes in terms of a higher degree of connection anonymity. Additionally, the proposed scheme allows the system operator to partition the optical network units (ONUs) into appropriate groups so as to achieve a better degree of anonymity.

System, methods and apparatus for program optimization for multi-threaded processor architectures

DOEpatents

Bastoul, Cedric; Lethin, Richard A; Leung, Allen K; Meister, Benoit J; Szilagyi, Peter; Vasilache, Nicolas T; Wohlford, David E

2015-01-06

Methods, apparatus and computer software product for source code optimization are provided. In an exemplary embodiment, a first custom computing apparatus is used to optimize the execution of source code on a second computing apparatus. In this embodiment, the first custom computing apparatus contains a memory, a storage medium and at least one processor with at least one multi-stage execution unit. The second computing apparatus contains at least two multi-stage execution units that allow for parallel execution of tasks. The first custom computing apparatus optimizes the code for parallelism, locality of operations and contiguity of memory accesses on the second computing apparatus. This Abstract is provided for the sole purpose of complying with the Abstract requirement rules. This Abstract is submitted with the explicit understanding that it will not be used to interpret or to limit the scope or the meaning of the claims.

A qualitative study on physicians' perceptions of specialty characteristics.

PubMed

Park, Kwi Hwa; Jun, Soo-Koung; Park, Ie Byung

2016-09-01

There has been limited research on physicians' perceptions of the specialty characteristics that are needed to sustain a successful career in medical specialties in Korea. Medical Specialty Preference Inventory in the United States or SCI59 (specialty choice inventory) in the United Kingdom are implemented to help medical students plan their careers. The purpose of this study was to explore the characteristics of the major specialties in Korea. Twelve physicians from different specialties participated in an exploratory study consisting of qualitative interviews about the personal ability and emotional characteristics and job attributes of each specialty. The collected data were analysed with content analysis methods. Twelve codes were extracted for ability & skill attributes, 23 codes for emotion & attitude attributes, and 12 codes for job attributes. Each specialty shows a different profile in terms of its characteristic attributes. The findings have implications for the design of career planning programs for medical students.

Miscellaneous streamflow measurements in the State of Washington, January 1961 to September 1985

USGS Publications Warehouse

Williams, John R.; Riis, S.A.

1989-01-01

This report is a compilation of previously published miscellaneous streamflow measurements made in Washington State by the U.S. Geological Survey between January 1961 and September 1985. It is a supplement to a volume of similar data for the period 1890 to January 1961. The data include stream name and stream to which it is tributary, latitude and longitude, county code, hydrologic unit code, land-line location, drainage area, and measurement dates and discharges. In general, the data sites are not at gaging stations; however, some data are given for gaging station sites during periods when the stations were not in operation. All data in this report have been entered into a computerized data base that includes the data for the period 1890 to January 1961. The data can be retrieved in a variety of ways, such as by county, by hydrologic unit code, by river basin , or by size of drainage area. (USGS)

A Simple Secure Hash Function Scheme Using Multiple Chaotic Maps

NASA Astrophysics Data System (ADS)

Ahmad, Musheer; Khurana, Shruti; Singh, Sushmita; AlSharari, Hamed D.

2017-06-01

The chaotic maps posses high parameter sensitivity, random-like behavior and one-way computations, which favor the construction of cryptographic hash functions. In this paper, we propose to present a novel hash function scheme which uses multiple chaotic maps to generate efficient variable-sized hash functions. The message is divided into four parts, each part is processed by a different 1D chaotic map unit yielding intermediate hash code. The four codes are concatenated to two blocks, then each block is processed through 2D chaotic map unit separately. The final hash value is generated by combining the two partial hash codes. The simulation analyses such as distribution of hashes, statistical properties of confusion and diffusion, message and key sensitivity, collision resistance and flexibility are performed. The results reveal that the proposed anticipated hash scheme is simple, efficient and holds comparable capabilities when compared with some recent chaos-based hash algorithms.

More Than Bar Codes: Integrating Global Standards-Based Bar Code Technology Into National Health Information Systems in Ethiopia and Pakistan to Increase End-to-End Supply Chain Visibility.

PubMed

Hara, Liuichi; Guirguis, Ramy; Hummel, Keith; Villanueva, Monica

2017-12-28

The United Nations Population Fund (UNFPA) and the United States Agency for International Development (USAID) DELIVER PROJECT work together to strengthen public health commodity supply chains by standardizing bar coding under a single set of global standards. From 2015, UNFPA and USAID collaborated to pilot test how tracking and tracing of bar coded health products could be operationalized in the public health supply chains of Ethiopia and Pakistan and inform the ecosystem needed to begin full implementation. Pakistan had been using proprietary bar codes for inventory management of contraceptive supplies but transitioned to global standards-based bar codes during the pilot. The transition allowed Pakistan to leverage the original bar codes that were preprinted by global manufacturers as opposed to printing new bar codes at the central warehouse. However, barriers at lower service delivery levels prevented full realization of end-to-end data visibility. Key barriers at the district level were the lack of a digital inventory management system and absence of bar codes at the primary-level packaging level, such as single blister packs. The team in Ethiopia developed an open-sourced smartphone application that allowed the team to scan bar codes using the mobile phone's camera and to push the captured data to the country's data mart. Real-time tracking and tracing occurred from the central warehouse to the Addis Ababa distribution hub and to 2 health centers. These pilots demonstrated that standardized product identification and bar codes can significantly improve accuracy over manual stock counts while significantly streamlining the stock-taking process, resulting in efficiencies. The pilots also showed that bar coding technology by itself is not sufficient to ensure data visibility. Rather, by using global standards for identification and data capture of pharmaceuticals and medical devices, and integrating the data captured into national and global tracking systems, countries are able to lay the foundation for interoperability and ensure a harmonized language between global health stakeholders. © Hara et al.

More Than Bar Codes: Integrating Global Standards-Based Bar Code Technology Into National Health Information Systems in Ethiopia and Pakistan to Increase End-to-End Supply Chain Visibility

PubMed Central

Hara, Liuichi; Guirguis, Ramy; Hummel, Keith; Villanueva, Monica

2017-01-01

The United Nations Population Fund (UNFPA) and the United States Agency for International Development (USAID) DELIVER PROJECT work together to strengthen public health commodity supply chains by standardizing bar coding under a single set of global standards. From 2015, UNFPA and USAID collaborated to pilot test how tracking and tracing of bar coded health products could be operationalized in the public health supply chains of Ethiopia and Pakistan and inform the ecosystem needed to begin full implementation. Pakistan had been using proprietary bar codes for inventory management of contraceptive supplies but transitioned to global standards-based bar codes during the pilot. The transition allowed Pakistan to leverage the original bar codes that were preprinted by global manufacturers as opposed to printing new bar codes at the central warehouse. However, barriers at lower service delivery levels prevented full realization of end-to-end data visibility. Key barriers at the district level were the lack of a digital inventory management system and absence of bar codes at the primary-level packaging level, such as single blister packs. The team in Ethiopia developed an open-sourced smartphone application that allowed the team to scan bar codes using the mobile phone's camera and to push the captured data to the country's data mart. Real-time tracking and tracing occurred from the central warehouse to the Addis Ababa distribution hub and to 2 health centers. These pilots demonstrated that standardized product identification and bar codes can significantly improve accuracy over manual stock counts while significantly streamlining the stock-taking process, resulting in efficiencies. The pilots also showed that bar coding technology by itself is not sufficient to ensure data visibility. Rather, by using global standards for identification and data capture of pharmaceuticals and medical devices, and integrating the data captured into national and global tracking systems, countries are able to lay the foundation for interoperability and ensure a harmonized language between global health stakeholders. PMID:29284701

Validating malignant melanoma ICD-9-CM codes in Umbria, ASL Napoli 3 Sud and Friuli Venezia Giulia administrative healthcare databases: a diagnostic accuracy study.

PubMed

Orso, Massimiliano; Serraino, Diego; Abraha, Iosief; Fusco, Mario; Giovannini, Gianni; Casucci, Paola; Cozzolino, Francesco; Granata, Annalisa; Gobbato, Michele; Stracci, Fabrizio; Ciullo, Valerio; Vitale, Maria Francesca; Eusebi, Paolo; Orlandi, Walter; Montedori, Alessandro; Bidoli, Ettore

2018-04-20

To assess the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in identifying subjects with melanoma. A diagnostic accuracy study comparing melanoma ICD-9-CM codes (index test) with medical chart (reference standard). Case ascertainment was based on neoplastic lesion of the skin and a histological diagnosis from a primary or metastatic site positive for melanoma. Administrative databases from Umbria Region, Azienda Sanitaria Locale (ASL) Napoli 3 Sud (NA) and Friuli Venezia Giulia (FVG) Region. 112, 130 and 130 cases (subjects with melanoma) were randomly selected from Umbria, NA and FVG, respectively; 94 non-cases (subjects without melanoma) were randomly selected from each unit. Sensitivity and specificity for ICD-9-CM code 172.x located in primary position. The most common melanoma subtype was malignant melanoma of skin of trunk, except scrotum (ICD-9-CM code: 172.5), followed by malignant melanoma of skin of lower limb, including hip (ICD-9-CM code: 172.7). The mean age of the patients ranged from 60 to 61 years. Most of the diagnoses were performed in surgical departments.The sensitivities were 100% (95% CI 96% to 100%) for Umbria, 99% (95% CI 94% to 100%) for NA and 98% (95% CI 93% to 100%) for FVG. The specificities were 88% (95% CI 80% to 93%) for Umbria, 77% (95% CI 69% to 85%) for NA and 79% (95% CI 71% to 86%) for FVG. The case definition for melanoma based on clinical or instrumental diagnosis, confirmed by histological examination, showed excellent sensitivities and good specificities in the three operative units. Administrative databases from the three operative units can be used for epidemiological and outcome research of melanoma. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Validating malignant melanoma ICD-9-CM codes in Umbria, ASL Napoli 3 Sud and Friuli Venezia Giulia administrative healthcare databases: a diagnostic accuracy study

PubMed Central

Orso, Massimiliano; Serraino, Diego; Fusco, Mario; Giovannini, Gianni; Casucci, Paola; Cozzolino, Francesco; Granata, Annalisa; Gobbato, Michele; Stracci, Fabrizio; Ciullo, Valerio; Vitale, Maria Francesca; Orlandi, Walter; Montedori, Alessandro; Bidoli, Ettore

2018-01-01

Objectives To assess the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in identifying subjects with melanoma. Design A diagnostic accuracy study comparing melanoma ICD-9-CM codes (index test) with medical chart (reference standard). Case ascertainment was based on neoplastic lesion of the skin and a histological diagnosis from a primary or metastatic site positive for melanoma. Setting Administrative databases from Umbria Region, Azienda Sanitaria Locale (ASL) Napoli 3 Sud (NA) and Friuli Venezia Giulia (FVG) Region. Participants 112, 130 and 130 cases (subjects with melanoma) were randomly selected from Umbria, NA and FVG, respectively; 94 non-cases (subjects without melanoma) were randomly selected from each unit. Outcome measures Sensitivity and specificity for ICD-9-CM code 172.x located in primary position. Results The most common melanoma subtype was malignant melanoma of skin of trunk, except scrotum (ICD-9-CM code: 172.5), followed by malignant melanoma of skin of lower limb, including hip (ICD-9-CM code: 172.7). The mean age of the patients ranged from 60 to 61 years. Most of the diagnoses were performed in surgical departments. The sensitivities were 100% (95% CI 96% to 100%) for Umbria, 99% (95% CI 94% to 100%) for NA and 98% (95% CI 93% to 100%) for FVG. The specificities were 88% (95% CI 80% to 93%) for Umbria, 77% (95% CI 69% to 85%) for NA and 79% (95% CI 71% to 86%) for FVG. Conclusions The case definition for melanoma based on clinical or instrumental diagnosis, confirmed by histological examination, showed excellent sensitivities and good specificities in the three operative units. Administrative databases from the three operative units can be used for epidemiological and outcome research of melanoma. PMID:29678984

Integrating advanced practice providers into medical critical care teams.

PubMed

McCarthy, Christine; O'Rourke, Nancy C; Madison, J Mark

2013-03-01

Because there is increasing demand for critical care providers in the United States, many medical ICUs for adults have begun to integrate nurse practitioners and physician assistants into their medical teams. Studies suggest that such advanced practice providers (APPs), when appropriately trained in acute care, can be highly effective in helping to deliver high-quality medical critical care and can be important elements of teams with multiple providers, including those with medical house staff. One aspect of building an integrated team is a practice model that features appropriate coding and billing of services by all providers. Therefore, it is important to understand an APP's scope of practice, when they are qualified for reimbursement, and how they may appropriately coordinate coding and billing with other team providers. In particular, understanding when and how to appropriately code for critical care services (Current Procedural Terminology [CPT] code 99291, critical care, evaluation and management of the critically ill or critically injured patient, first 30-74 min; CPT code 99292, critical care, each additional 30 min) and procedures is vital for creating a sustainable program. Because APPs will likely play a growing role in medical critical care units in the future, more studies are needed to compare different practice models and to determine the best way to deploy this talent in specific ICU settings.

7 CFR 400.767 - Requester obligations.

Code of Federal Regulations, 2011 CFR

2011-01-01

....gov; or (iv) By overnight delivery to the Associate Administrator, Risk Management Agency, United... subpart must: (1) Be submitted: (i) In writing by certified mail, to the Associate Administrator, Risk Management Agency, United States Department of Agriculture, Stop Code 0801, 1400 Independence Avenue, SW...

7 CFR 400.767 - Requester obligations.

Code of Federal Regulations, 2010 CFR

2010-01-01

....gov; or (iv) By overnight delivery to the Associate Administrator, Risk Management Agency, United... subpart must: (1) Be submitted: (i) In writing by certified mail, to the Associate Administrator, Risk Management Agency, United States Department of Agriculture, Stop Code 0801, 1400 Independence Avenue, SW...

A volcanic activity alert-level system for aviation: Review of its development and application in Alaska

USGS Publications Warehouse

Guffanti, Marianne C.; Miller, Thomas

2013-01-01

An alert-level system for communicating volcano hazard information to the aviation industry was devised by the Alaska Volcano Observatory (AVO) during the 1989–1990 eruption of Redoubt Volcano. The system uses a simple, color-coded ranking that focuses on volcanic ash emissions: Green—normal background; Yellow—signs of unrest; Orange—precursory unrest or minor ash eruption; Red—major ash eruption imminent or underway. The color code has been successfully applied on a regional scale in Alaska for a sustained period. During 2002–2011, elevated color codes were assigned by AVO to 13 volcanoes, eight of which erupted; for that decade, one or more Alaskan volcanoes were at Yellow on 67 % of days and at Orange or Red on 12 % of days. As evidence of its utility, the color code system is integrated into procedures of agencies responsible for air-traffic management and aviation meteorology in Alaska. Furthermore, it is endorsed as a key part of globally coordinated protocols established by the International Civil Aviation Organization to provide warnings of ash hazards to aviation worldwide. The color code and accompanying structured message (called a Volcano Observatory Notice for Aviation) comprise an effective early-warning message system according to the United Nations International Strategy for Disaster Reduction. The aviation color code system currently is used in the United States, Russia, New Zealand, Iceland, and partially in the Philippines, Papua New Guinea, and Indonesia. Although there are some barriers to implementation, with continued education and outreach to Volcano Observatories worldwide, greater use of the aviation color code system is achievable.

A volcanic activity alert-level system for aviation: review of its development and application in Alaska

USGS Publications Warehouse

Guffanti, Marianne; Miller, Thomas P.

2013-01-01

An alert-level system for communicating volcano hazard information to the aviation industry was devised by the Alaska Volcano Observatory (AVO) during the 1989–1990 eruption of Redoubt Volcano. The system uses a simple, color-coded ranking that focuses on volcanic ash emissions: Green—normal background; Yellow—signs of unrest; Orange—precursory unrest or minor ash eruption; Red—major ash eruption imminent or underway. The color code has been successfully applied on a regional scale in Alaska for a sustained period. During 2002–2011, elevated color codes were assigned by AVO to 13 volcanoes, eight of which erupted; for that decade, one or more Alaskan volcanoes were at Yellow on 67 % of days and at Orange or Red on 12 % of days. As evidence of its utility, the color code system is integrated into procedures of agencies responsible for air-traffic management and aviation meteorology in Alaska. Furthermore, it is endorsed as a key part of globally coordinated protocols established by the International Civil Aviation Organization to provide warnings of ash hazards to aviation worldwide. The color code and accompanying structured message (called a Volcano Observatory Notice for Aviation) comprise an effective early-warning message system according to the United Nations International Strategy for Disaster Reduction. The aviation color code system currently is used in the United States, Russia, New Zealand, Iceland, and partially in the Philippines, Papua New Guinea, and Indonesia. Although there are some barriers to implementation, with continued education and outreach to Volcano Observatories worldwide, greater use of the aviation color code system is achievable.

The static evolution of the new Italian code of medical ethics.

PubMed

Montanari Vergallo, G; Busardò, F P; Zaami, S; Marinelli, E

2016-01-01

Eight years since the last revision, in May 2014 the Italian code of medical ethics has been updated. Here, the Authors examine the reform in the light of the increasing difficulties of the medical profession arising from the severity of the Italian law Courts. The most significant aspects of this new code are firstly, the patient's freedom of self-determination and secondly, risk prevention through the disclosure of errors and adverse events. However, in both areas the reform seems to be less effective if we compare the ethical codes of France, the United Kingdom and the United States. In particular, the non-taking into consideration of the said code quality standards and scientific evidence which should guide doctors in their clinical practice is to say the least questionable. Since these are the most significant changes in the new code, it seems inevitable to conclude that the 2014 edition is essentially in line with previous versions. Now more than ever it is necessary that medical ethics acknowledges that medicine, society and medical jurisprudence have changed and doctors must be given new rules in order to protect both patients' rights and dignity of the profession. The physician's right to refuse to perform treatment at odds with his own clinical beliefs cannot be the only mean to safeguard the dignity of the profession. A clear boundary must also be established between medicine and professionalism as well as the criteria in determining the scientific evidences that physicians must follow. This has not been done in the Italian code of ethics, despite all the controversy caused by the Stamina case.

Code for ethical international recruitment practices: the CGFNS alliance case study.

PubMed

Shaffer, Franklin A; Bakhshi, Mukul; Dutka, Julia To; Phillips, Janice

2016-06-30

Projections indicate a global workforce shortage of approximately 4.3 million across the health professions. The need to ensure an adequate supply of health workers worldwide has created a context for the increased global migration of these professionals. The global trend in the migration of health professionals has given rise to the international recruitment industry to facilitate the passage of health workers from source to destination countries. This is particularly the case in the United States, where the majority of immigrant health professionals have come by way of the recruiting industry. This industry is largely unregulated in the United States as well as in many other countries, for which voluntary codes have been used as a means to increase transparency of the recruitment process, shape professional conduct, and mitigate harm to foreign-educated health workers. The CGFNS Alliance case study presented herein describes a multi-stakeholder effort in the United States to promote ethical recruitment practices. Such codes not only complement the WHO Global Code of Practice but are necessary to maximize the impact of these global standards on local settings. This case study offers both a historical perspective and a conceptual framework for examining the multiplicity of factors affecting the migration of human resources for health. The lessons learned provide critical insights into the factors pertaining to the relevancy and effectiveness of the WHO Code from the perspectives of both source and destination countries. This study provides a conceptual model for examining the usefulness of the WHO Code as well as how best to ensure its viability, sustainability, relevancy, and effectiveness in the global environment. This case study concludes with recommendations for evolving business models that need to be in place to strengthen the effectiveness of the WHO Code in the marketplace and to ensure its impact on the international recruitment industry in advancing ethical practices. These recommendations include using effective screening mechanisms to determine health professionals' readiness for migration as well as implementing certification processes to raise the practice standards for those directly involved in recruiting skilled workers and managing the migration flow.

A Verification-Driven Approach to Traceability and Documentation for Auto-Generated Mathematical Software

NASA Technical Reports Server (NTRS)

Denney, Ewen W.; Fischer, Bernd

2009-01-01

Model-based development and automated code generation are increasingly used for production code in safety-critical applications, but since code generators are typically not qualified, the generated code must still be fully tested, reviewed, and certified. This is particularly arduous for mathematical and control engineering software which requires reviewers to trace subtle details of textbook formulas and algorithms to the code, and to match requirements (e.g., physical units or coordinate frames) not represented explicitly in models or code. Both tasks are complicated by the often opaque nature of auto-generated code. We address these problems by developing a verification-driven approach to traceability and documentation. We apply the AUTOCERT verification system to identify and then verify mathematical concepts in the code, based on a mathematical domain theory, and then use these verified traceability links between concepts, code, and verification conditions to construct a natural language report that provides a high-level structured argument explaining why and how the code uses the assumptions and complies with the requirements. We have applied our approach to generate review documents for several sub-systems of NASA s Project Constellation.

Design of a Microprogram Control Unit with Concurrent Error Detection.

DTIC Science & Technology

1984-08-01

I fxoot Office of Naval Research N/A N00039-80-C-0556 ta. ADDRESS (City. St.. and ZIP Cod 10. SOURCE OF FUNOING N0. -PROGRAM PROJECT TASK WORK UNIT...However, the CED concept is mainly applied to various codes data transmission, and simple functional units, such as arithmetic units. Little work has...been done in the control unit area. Previous work is primarily in the use of clanical self-checking circuits, using bit slicin& parity, and m-out-of-n

Designing a Common Interchange Format for Unit Data Using the Command and Control Information Exchange Data Model (C2IEDM) and XSLT

DTIC Science & Technology

2004-09-01

Required> </Equipment> <Equipment code="L44680"> <Description>LAUNCHER GRENADE SMOKE: SCREENING RP M250 </Description> <Required...EquipmentPiecesOnHand> </UnitEquipment> <UnitEquipment> <EquipmentDescription>LAUNCHER GRENADE SMOKE: SCREENING RP M250 </EquipmentDescription

Report on the Program and Contract Infrastructure Technical Requirements Development for the Guam Realignment Program

DTIC Science & Technology

2012-02-08

Office GRN Guam Road Network GWA Guam Waterworks Authority ICG Interagency Coordination Group JFY Japanese Fiscal Year JRM Joint...PAC) (Pacific) NCTS Naval Computer and Telecommunications Station NEPA National Environmental Policy Act NPDES National Pollutant Discharge...Elimination System OPNAV Operational Navy UFC Unified Facilities Criteria U.S. United States USC United States Code USDA United States

Know Your America: Suggested Study Course in Americanism. Revised Edition.

ERIC Educational Resources Information Center

American Legion, Indianapolis, IN. Americanism and Children's Youth Div.

The purpose of this booklet is to increase understanding of fundamental U.S. documents, the U.S. flag, patriotic institutions, and of San Francisco (California), March 14-16, 1986 of U.S. residents. Unit 2 describes and interprets the code of displaying the U.S. flag and provides a suggested flag education unit of study. Units 3 and 4 offer…

Programmatic Environmental Assessment for Base General Plan Development, Schriever Air Force Base, Colorado

DTIC Science & Technology

2012-06-01

will not involve an element of high risk or uncertainty on the human environment, and its effects on the quality of the human environment are not...Information System HAPs Hazardous air pollutants HAZMAT Hazardous Material HVAC heating, ventilation , and air conditioning HUD U.S. Housing and...Engineers USAF Unites States Air Force USC United States Code USEPA United States Environmental Protection Agency USFWS United States Fish and Wildlife

Fair Use and Unpublished Works. Joint Hearing on S. 2370 and H.R. 4263, Bills To Amend Section 107 of Title 17, United States Code...before the Subcommittee on Patents, Copyrights, and Trademarks of the Senate Committee on the Judiciary and the Subcommittee on Courts, Intellectual Property, and the Administration of Justice of the House Committee on the Judiciary.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on the Judiciary.

This hearing was called to consider two bills that would amend the section of the United States Code relating to fair use, to clarify that such section applies to both published and unpublished copyrighted works. Recent judicial developments are reviewed which suggest that the fair use doctrine does not apply to the subsequent uses of unpublished…

A study of high density bit transition requirements versus the effects on BCH error correcting coding

NASA Technical Reports Server (NTRS)

Ingels, F.; Schoggen, W. O.

1981-01-01

Several methods for increasing bit transition densities in a data stream are summarized, discussed in detail, and compared against constraints imposed by the 2 MHz data link of the space shuttle high rate multiplexer unit. These methods include use of alternate pulse code modulation waveforms, data stream modification by insertion, alternate bit inversion, differential encoding, error encoding, and use of bit scramblers. The psuedo-random cover sequence generator was chosen for application to the 2 MHz data link of the space shuttle high rate multiplexer unit. This method is fully analyzed and a design implementation proposed.

Optimized bit extraction using distortion modeling in the scalable extension of H.264/AVC.

PubMed

Maani, Ehsan; Katsaggelos, Aggelos K

2009-09-01

The newly adopted scalable extension of H.264/AVC video coding standard (SVC) demonstrates significant improvements in coding efficiency in addition to an increased degree of supported scalability relative to the scalable profiles of prior video coding standards. Due to the complicated hierarchical prediction structure of the SVC and the concept of key pictures, content-aware rate adaptation of SVC bit streams to intermediate bit rates is a nontrivial task. The concept of quality layers has been introduced in the design of the SVC to allow for fast content-aware prioritized rate adaptation. However, existing quality layer assignment methods are suboptimal and do not consider all network abstraction layer (NAL) units from different layers for the optimization. In this paper, we first propose a technique to accurately and efficiently estimate the quality degradation resulting from discarding an arbitrary number of NAL units from multiple layers of a bitstream by properly taking drift into account. Then, we utilize this distortion estimation technique to assign quality layers to NAL units for a more efficient extraction. Experimental results show that a significant gain can be achieved by the proposed scheme.

High-Speed Particle-in-Cell Simulation Parallelized with Graphic Processing Units for Low Temperature Plasmas for Material Processing

NASA Astrophysics Data System (ADS)

Hur, Min Young; Verboncoeur, John; Lee, Hae June

2014-10-01

Particle-in-cell (PIC) simulations have high fidelity in the plasma device requiring transient kinetic modeling compared with fluid simulations. It uses less approximation on the plasma kinetics but requires many particles and grids to observe the semantic results. It means that the simulation spends lots of simulation time in proportion to the number of particles. Therefore, PIC simulation needs high performance computing. In this research, a graphic processing unit (GPU) is adopted for high performance computing of PIC simulation for low temperature discharge plasmas. GPUs have many-core processors and high memory bandwidth compared with a central processing unit (CPU). NVIDIA GeForce GPUs were used for the test with hundreds of cores which show cost-effective performance. PIC code algorithm is divided into two modules which are a field solver and a particle mover. The particle mover module is divided into four routines which are named move, boundary, Monte Carlo collision (MCC), and deposit. Overall, the GPU code solves particle motions as well as electrostatic potential in two-dimensional geometry almost 30 times faster than a single CPU code. This work was supported by the Korea Institute of Science Technology Information.

Uneven-Layered Coding Metamaterial Tile for Ultra-wideband RCS Reduction and Diffuse Scattering.

PubMed

Su, Jianxun; He, Huan; Li, Zengrui; Yang, Yaoqing Lamar; Yin, Hongcheng; Wang, Junhong

2018-05-25

In this paper, a novel uneven-layered coding metamaterial tile is proposed for ultra-wideband radar cross section (RCS) reduction and diffuse scattering. The metamaterial tile is composed of two kinds of square ring unit cells with different layer thickness. The reflection phase difference of 180° (±37°) between two unit cells covers an ultra-wide frequency range. Due to the phase cancellation between two unit cells, the metamaterial tile has the scattering pattern of four strong lobes deviating from normal direction. The metamaterial tile and its 90-degree rotation can be encoded as the '0' and '1' elements to cover an object, and diffuse scattering pattern can be realized by optimizing phase distribution, leading to reductions of the monostatic and bi-static RCSs simultaneously. The metamaterial tile can achieve -10 dB RCS reduction from 6.2 GHz to 25.7 GHz with the ratio bandwidth of 4.15:1 at normal incidence. The measured and simulated results are in good agreement and validate the proposed uneven-layered coding metamaterial tile can greatly expanding the bandwidth for RCS reduction and diffuse scattering.

Hanford facility dangerous waste permit application, general information portion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hays, C.B.

1998-05-19

The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOE/RL-91-28) and a Unit-Specific Portion. Both the General Information and Unit-Specific portions of the Hanford Facility Dangerous Waste Permit Application address the content of the Part B permit application guidance prepared by the Washington State Department of Ecology (Ecology 1996) and the U.S. Environmental Protection Agency (40 Code of Federal Regulations 270), with additional information needed by the Hazardous and Solid Waste Amendments and revisions of Washington Administrative Code 173-303. Documentation contained in the General Information Portion ismore » broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in this report).« less

24 CFR 880.207 - Property standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

... State and local laws, codes, ordinances and regulations. (g) Smoke detectors—(1) Performance requirement... smoke detector, in proper working condition, on each level of the unit. If the unit is occupied by hearing-impaired persons, smoke detectors must have an alarm system, designed for hearing-impaired persons...

24 CFR 880.207 - Property standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... State and local laws, codes, ordinances and regulations. (g) Smoke detectors—(1) Performance requirement... smoke detector, in proper working condition, on each level of the unit. If the unit is occupied by hearing-impaired persons, smoke detectors must have an alarm system, designed for hearing-impaired persons...

24 CFR 880.207 - Property standards.

Code of Federal Regulations, 2011 CFR

2011-04-01

... State and local laws, codes, ordinances and regulations. (g) Smoke detectors—(1) Performance requirement... smoke detector, in proper working condition, on each level of the unit. If the unit is occupied by hearing-impaired persons, smoke detectors must have an alarm system, designed for hearing-impaired persons...

24 CFR 880.207 - Property standards.

Code of Federal Regulations, 2014 CFR

2014-04-01

... State and local laws, codes, ordinances and regulations. (g) Smoke detectors—(1) Performance requirement... smoke detector, in proper working condition, on each level of the unit. If the unit is occupied by hearing-impaired persons, smoke detectors must have an alarm system, designed for hearing-impaired persons...