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; the U.S. Departments of Defense, Interior, Agriculture, Commerce, Housing and Urban Development United States Advisory Council on Historic Preservation logo U.S. Department of the Interior seal U.S Department of the Interior (DOI) and the Advisory Council on Historic Preservation (ACHP) have announced the

KSC-97PC1515

NASA Image and Video Library

1997-10-02

Participating in the Crew Equipment Integration Test (CEIT) at Kennedy Space Center are STS-87 crew members, assisted by Glenda Laws, extravehicular activity (EVA) coordinator, Johnson Space Center, at left. Next to Laws is Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, who is looking on as Mission Specialist Winston Scott gets a hands-on look at some of the equipment. The STS-87 mission will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks

Thalamic reticular nucleus induces fast and local modulation of arousal state

PubMed Central

Lewis, Laura D; Voigts, Jakob; Flores, Francisco J; Schmitt, L Ian; Wilson, Matthew A

2015-01-01

During low arousal states such as drowsiness and sleep, cortical neurons exhibit rhythmic slow wave activity associated with periods of neuronal silence. Slow waves are locally regulated, and local slow wave dynamics are important for memory, cognition, and behaviour. While several brainstem structures for controlling global sleep states have now been well characterized, a mechanism underlying fast and local modulation of cortical slow waves has not been identified. Here, using optogenetics and whole cortex electrophysiology, we show that local tonic activation of thalamic reticular nucleus (TRN) rapidly induces slow wave activity in a spatially restricted region of cortex. These slow waves resemble those seen in sleep, as cortical units undergo periods of silence phase-locked to the slow wave. Furthermore, animals exhibit behavioural changes consistent with a decrease in arousal state during TRN stimulation. We conclude that TRN can induce rapid modulation of local cortical state. DOI: http://dx.doi.org/10.7554/eLife.08760.001 PMID:26460547

Agroforestry: Enhancing resiliency in U.S. agricultural landscapes under changing conditions - executive summary

Treesearch

Toral Patel-Weynand; Gary Bentrup; Michele M. Schoeneberger

2017-01-01

Agroforestry, the intentional integration of trees and shrubs into crop and animal production systems, is being deployed to enhance productivity, profitability, and environmental stewardship of agricultural operations and lands across the United States. The full assessment at https://doi.org/10.2737/WO-GTR-96...

The self-organization of grid cells in 3D

PubMed Central

Stella, Federico; Treves, Alessandro

2015-01-01

Do we expect periodic grid cells to emerge in bats, or perhaps dolphins, exploring a three-dimensional environment? How long will it take? Our self-organizing model, based on ring-rate adaptation, points at a complex answer. The mathematical analysis leads to asymptotic states resembling face centered cubic (FCC) and hexagonal close packed (HCP) crystal structures, which are calculated to be very close to each other in terms of cost function. The simulation of the full model, however, shows that the approach to such asymptotic states involves several sub-processes over distinct time scales. The smoothing of the initially irregular multiple fields of individual units and their arrangement into hexagonal grids over certain best planes are observed to occur relatively quickly, even in large 3D volumes. The correct mutual orientation of the planes, though, and the coordinated arrangement of different units, take a longer time, with the network showing no sign of convergence towards either a pure FCC or HCP ordering. DOI: http://dx.doi.org/10.7554/eLife.05913.001 PMID:25821989

Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

PubMed Central

Rosselló, Ricardo Antonio; Chen, Chun-Chun; Dai, Rui; Howard, Jason T; Hochgeschwender, Ute; Jarvis, Erich D

2013-01-01

Cells are fundamental units of life, but little is known about evolution of cell states. Induced pluripotent stem cells (iPSCs) are once differentiated cells that have been re-programmed to an embryonic stem cell-like state, providing a powerful platform for biology and medicine. However, they have been limited to a few mammalian species. Here we found that a set of four mammalian transcription factor genes used to generate iPSCs in mouse and humans can induce a partially reprogrammed pluripotent stem cell (PRPSCs) state in vertebrate and invertebrate model organisms, in mammals, birds, fish, and fly, which span 550 million years from a common ancestor. These findings are one of the first to show cross-lineage stem cell-like induction, and to generate pluripotent-like cells for several of these species with in vivo chimeras. We suggest that the stem-cell state may be highly conserved across a wide phylogenetic range. DOI: http://dx.doi.org/10.7554/eLife.00036.001 PMID:24015354

KSC-97PC1511

NASA Image and Video Library

1997-10-02

Participating in the Crew Equipment Integration Test (CEIT) at Kennedy Space Center are STS-87 crew members Winston Scott, at left, and Takao Doi, Ph.D., of the National Space Development Agency of Japan, both mission specialists on STS-87. The CEIT gives astronauts an opportunity to get a hands-on look at the payloads with which they will be working on-orbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the STS-87 mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks. STS-87 is scheduled for a Nov. 19 liftoff from KSC

KSC-97PC1486

NASA Image and Video Library

1997-10-02

STS-87 astronaut crew members participate in the Crew Equipment Integration Test (CEIT) in Kennedy Space Center’s (KSC's) Vertical Processing Facility. From left are Mission Specialist Kalpana Chawla, Ph.D.; Pilot Steven Lindsey; Mission Specialist Takao Doi , Ph.D., of the National Space Development Agency of Japan; and Mission Specialist Winston Scott. The CEIT gives astronauts an opportunity to get a hands-on look at the payloads with which they will be working onorbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the STS-87 mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks

STS-87 Mission Specialist Doi addresses the media at the SLF

NASA Technical Reports Server (NTRS)

1997-01-01

As STS-87 Commander Kevin Kregel looks on, Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan addresses members of the press and media at Kennedy Space Center's Shuttle Landing Facility after arriving for the final prelaunch activities leading up to the scheduled Nov. 19 liftoff. Other STS-87 crew members not pictured are Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., and Winston Scott; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. STS-87 will be the fourth flight of the United States Microgravity Payload and the Spartan-201 deployable satellite.

U.S. Department of the Interior South Central Climate Science Center

USGS Publications Warehouse

Shipp, Allison A.

2012-01-01

On September 14, 2009, the Secretary of the Interior signed a Secretarial Order (No. 3289) entitled, "Addressing the Impacts of Climate Change on America's Water, Land, and Other Natural and Cultural Resources." The Order effectively established the U.S. Department of the Interior (DOI) Climate Science Centers (CSCs) for the purpose of integrating DOI science and management expertise with similar contributions from our partners to provide information to support strategic adaptation and mitigation efforts on public and private lands across the United States and internationally. The South Central Climate Science Center (SC CSC) is supported by a consortium of partners that include The University of Oklahoma, Texas Tech University, Louisiana State University, The Chickasaw Nation, The Choctaw Nation of Oklahoma, Oklahoma State University, and the National Oceanic and Atmospheric Administration's Geophysical Fluid Dynamics Laboratory. Additionally, the SC CSC will collaborate with a number of other universities, State and federal agencies, and nongovernmental organizations (NGOs) with interests and expertise in climate science. The primary partners of the SC CSC are the Landscape Conservation Cooperatives (LCCs), which include the Desert, Eastern Tallgrass Prairie and Big Rivers, Great Plains, Gulf Coast Prairie, Gulf Coastal Plains and Ozarks, and Southern Rockies. CSC collaborations are focused on common science priorities that address priority partner needs, eliminate redundancies in science, share scientific information and findings, and expand understanding of climate change impacts in the south-central United States and Mexico.

The State Geologic Map Compilation (SGMC) geodatabase of the conterminous United States

USGS Publications Warehouse

Horton, John D.; San Juan, Carma A.; Stoeser, Douglas B.

2017-06-30

The State Geologic Map Compilation (SGMC) geodatabase of the conterminous United States (https://doi. org/10.5066/F7WH2N65) represents a seamless, spatial database of 48 State geologic maps that range from 1:50,000 to 1:1,000,000 scale. A national digital geologic map database is essential in interpreting other datasets that support numerous types of national-scale studies and assessments, such as those that provide geochemistry, remote sensing, or geophysical data. The SGMC is a compilation of the individual U.S. Geological Survey releases of the Preliminary Integrated Geologic Map Databases for the United States. The SGMC geodatabase also contains updated data for seven States and seven entirely new State geologic maps that have been added since the preliminary databases were published. Numerous errors have been corrected and enhancements added to the preliminary datasets using thorough quality assurance/quality control procedures. The SGMC is not a truly integrated geologic map database because geologic units have not been reconciled across State boundaries. However, the geologic data contained in each State geologic map have been standardized to allow spatial analyses of lithology, age, and stratigraphy at a national scale.

75 FR 44276 - Vendor Outreach Workshop for Small Businesses in the Midwest Region of the United States

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-28

... business interested in working with the Department, we urge you to register online at: http://www.doi.gov... DEPARTMENT OF THE INTERIOR Office of the Secretary Vendor Outreach Workshop for Small Businesses.... SUMMARY: The Office of Small and Disadvantaged Business Utilization of the Department of the Interior is...

30 CFR 1229.109 - Reimbursement for costs incurred by a State under the delegation of authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... under the delegation of authority. (a) The Department of the Interior (DOI) shall reimburse the State... DOI and will provide the DOI, on a quarterly basis, a summary of costs incurred for which the State is...

STS-87 crew participates in Crew Equipment Interface Test

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 astronaut crew members participate in the Crew Equipment Integration Test (CEIT) in Kennedy Space Centers (KSC's) Vertical Processing Facility. From left are Mission Specialist Kalpana Chawla, Ph.D.; Pilot Steven Lindsey; Mission Specialist Takao Doi , Ph.D., of the National Space Development Agency of Japan; and Mission Specialist Winston Scott. The CEIT gives astronauts an opportunity to get a hands-on look at the payloads with which they will be working on- orbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the STS-87 mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks.

STS-87 crew participates in Crew Equipment Interface Test

NASA Technical Reports Server (NTRS)

1997-01-01

Participating in the Crew Equipment Integration Test (CEIT) at Kennedy Space Center are STS-87 crew members Winston Scott, at left, and Takao Doi, Ph.D., of the National Space Development Agency of Japan, both mission specialists on STS-87. The CEIT gives astronauts an opportunity to get a hands-on look at the payloads with which they will be working on-orbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the STS-87 mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks. STS-87 is scheduled for a Nov. 19 liftoff from KSC.

STS-47 crew and backups at MSFC's Payload Crew Training Complex

NASA Technical Reports Server (NTRS)

1992-01-01

STS-47 Endeavour, Orbiter Vehicle (OV) 105, Spacelab Japan (SLJ) crewmembers and backup payload specialists stand outside SLJ module mockup at the Payload Crew Training Complex at Marshall SpaceFlight Center (MSFC) in Huntsville, Alabama. From left to right are Payload Specialist Mamoru Mohri, backup Payload Specialist Takao Doi, backup Payload Specialist Chiaki Naito-Mukai, Mission Specialist (MS) Mae C. Jemison, MS N. Jan Davis, backup Payload Specialist Stan Koszelak, and MS and Payload Commander (PLC) Mark C. Lee. The MSFC-managed mission is a joint venture in space-based research between the United States and Japan. Mohri, Doi, and Mukai represent Japan's National Space Development Agency (NASDA). View provided with alternate number 92P-142.

Toward a Global 1/25 deg HYCOM Ocean Prediction System with Tides

DTIC Science & Technology

2011-09-30

Wallcraft, C. Lozano, H. L.Tolman, A. Srinivasan, S. Hankin, P. Cornillon, R. Weisberg, A. Barth, R. He, C. Werner, and J. Wilkin , 2009. U.S. GODAE...United States. Climate Dynamics, doi:10.1007/s00382-010-0988-7. Xu, X., W.J. Schmitz Jr., H.E. Hurlburt, P.J. Hogan , and E.P. Chassignet, 2010. Transport

KSC-97PC1695

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1701

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1700

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1696

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1697

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1692

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1694

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1691

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1699

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

KSC-97PC1698

NASA Image and Video Library

1997-11-19

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers

STS-87 Columbia Launch

NASA Technical Reports Server (NTRS)

1997-01-01

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia soars from Launch Pad 39B at 2:46:00 p.m. EST, November 19, on the fourth flight of the United States Microgravity Payload and Spartan-201 satellite. The crew members include Mission Commander Kevin Kregel.; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., Winston Scott, and Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 16-day STS-87 mission, the crew will oversee experiments in microgravity; deploy and retrieve a solar satellite; and test a new experimental camera, the AERCam Sprint. Dr. Doi and Scott also will perform a spacewalk to practice International Space Station maneuvers.

Rapid assessment of U.S. forest and soil organic carbon storage and forest biomass carbon-sequestration capacity

USGS Publications Warehouse

Sundquist, Eric T.; Ackerman, Katherine V.; Bliss, Norman B.; Kellndorfer, Josef M.; Reeves, Matt C.; Rollins, Matthew G.

2009-01-01

This report provides results of a rapid assessment of biological carbon stocks and forest biomass carbon sequestration capacity in the conterminous United States. Maps available from the U.S. Department of Agriculture are used to calculate estimates of current organic carbon storage in soils (73 petagrams of carbon, or PgC) and forest biomass (17 PgC). Of these totals, 3.5 PgC of soil organic carbon and 0.8 PgC of forest biomass carbon occur on lands managed by the U.S. Department of the Interior (DOI). Maps of potential vegetation are used to estimate hypothetical forest biomass carbon sequestration capacities that are 3–7 PgC higher than current forest biomass carbon storage in the conterminous United States. Most of the estimated hypothetical additional forest biomass carbon sequestration capacity is accrued in areas currently occupied by agriculture and development. Hypothetical forest biomass carbon sequestration capacities calculated for existing forests and woodlands are within ±1 PgC of estimated current forest biomass carbon storage. Hypothetical forest biomass sequestration capacities on lands managed by the DOI in the conterminous United States are 0–0.4 PgC higher than existing forest biomass carbon storage. Implications for forest and other land management practices are not considered in this report. Uncertainties in the values reported here are large and difficult to quantify, particularly for hypothetical carbon sequestration capacities. Nevertheless, this rapid assessment helps to frame policy and management discussion by providing estimates that can be compared to amounts necessary to reduce predicted future atmospheric carbon dioxide levels.

A Democratic Vietnam; Not in the United States’ Core Interests

DTIC Science & Technology

2013-11-01

and human rights reform. There are two main reasons for this argument. First, economic reform and deregulation under the Doi Moi (Renovation...economic reform, deregulation of Vietnam’s growing capital market, and exposed Vietnamese society to western influences, the VCP has taken measures to...Security required a motorbike license, residence permit and proof of insurance for registration. 94 More controversially, the ministry also

Trade Group Rules Against China in Rare Earths Dispute

NASA Astrophysics Data System (ADS)

Showstack, Randy

2014-04-01

The World Trade Organization (WTO) has ruled against China in a trade dispute over rare earth elements (REE) as well as tungsten and molybdenum, the group announced on 26 March. The European Union, Japan, and the United States brought trade cases against China in March 2012 concerning alleged unfair export restraints on the materials (see Eos, 93(13), 134-135, doi:10.1029/2012EO130002).

30 CFR 229.109 - Reimbursement for costs incurred by a State under the delegation of authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... authority. (a) The Department of the Interior (DOI) shall reimburse the State for 100 percent of the direct... maintain books and records in accordance with the standards established by the DOI and will provide the DOI...

Department of the Interior Climate Science Centers

USGS Publications Warehouse

Jones, Sonya A.

2011-01-01

What is a Climate Science Center? On September 14, 2009, the Secretary of the Interior signed a Secretarial Order (No. 3289) entitled, "Addressing the Impacts of Climate Change on America's Water, Land, and Other Natural and Cultural Resources." The Order effectively established the U.S. Department of the Interior (DOI) Climate Science Centers (CSCs), which will integrate DOI science and management expertise with similar contributions from our partners to provide information to support adaptation and mitigation efforts on both public and private lands, across the United States and internationally.The Southeast CSC, hosted by NC State University (NCSU), will collaborate with a number of other universities, State and Federal agencies, and nongovernmental organizations (NGOs) with interest and expertise in climate science. The primary partner for the Southeast CSC will be the Landscape Conservation Cooperatives (LCCs) in the Southeast, including the Appalachian, Gulf Coastal Plains and Ozarks, Gulf Coast Prairie, Peninsular Florida, and the South Atlantic. CSC collaborations are focused on common science priorities, addressing priority partner needs, minimizing redundancies in science, sharing scientific findings, and expanding understanding of climate change impacts in the Southeast.

STS-87 crew participates in Crew Equipment Interface Test

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 astronaut crew members participate in the Crew Equipment Integration Test (CEIT) with the Spartan-201 payload in Kennedy Space Centers (KSC's) Vertical Processing Facility. From left are Pilot Steven Lindsey; Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Mission Specialist Kalpana Chawla, Ph.D.; Commander Kevin Kregel; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. The CEIT gives astronauts an opportunity to get a hands- on look at the payloads with which they will be working on-orbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the mission, Dr. Doi will be the first Japanese astronaut to perform a spacewalk. STS-87 is scheduled for a Nov. 19 liftoff from KSC.

KSC-97PC1488

NASA Image and Video Library

1997-10-02

STS-87 astronaut crew members prepare to fly back to Johnson Space Center in Houston after participating in the Crew Equipment Integration Test (CEIT) at Kennedy Space Center (KSC) in early October. From left are Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine; Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Mission Specialist Winston Scott; Commander Kevin Kregel; Pilot Steven Lindsey; and Mission Specialist Kalpana Chawla, Ph.D. The CEIT gives astronauts an opportunity to get a hands-on look at the payloads with which they will be working on-orbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the STS-87 mission, scheduled for a Nov. 19 liftoff from KSC, Dr. Doi and Scott will both perform spacewalks

KSC-97PC1481

NASA Image and Video Library

1997-10-02

STS-87 astronaut crew members participate in the Crew Equipment Integration Test (CEIT) with the Spartan-201 payload in Kennedy Space Center’s (KSC's) Vertical Processing Facility. From left are Pilot Steven Lindsey; Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Mission Specialist Kalpana Chawla, Ph.D.; Commander Kevin Kregel; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. The CEIT gives astronauts an opportunity to get a hands-on look at the payloads with which they will be working on-orbit. STS-87 will be the fourth United States Microgravity Payload and flight of the Spartan-201 deployable satellite. During the mission, Dr. Doi will be the first Japanese astronaut to perform a spacewalk. STS-87 is scheduled for a Nov. 19 liftoff from KSC

Spatial resolution recovery utilizing multi-ray tracing and graphic processing unit in PET image reconstruction.

PubMed

Liang, Yicheng; Peng, Hao

2015-02-07

Depth-of-interaction (DOI) poses a major challenge for a PET system to achieve uniform spatial resolution across the field-of-view, particularly for small animal and organ-dedicated PET systems. In this work, we implemented an analytical method to model system matrix for resolution recovery, which was then incorporated in PET image reconstruction on a graphical processing unit platform, due to its parallel processing capacity. The method utilizes the concepts of virtual DOI layers and multi-ray tracing to calculate the coincidence detection response function for a given line-of-response. The accuracy of the proposed method was validated for a small-bore PET insert to be used for simultaneous PET/MR breast imaging. In addition, the performance comparisons were studied among the following three cases: 1) no physical DOI and no resolution modeling; 2) two physical DOI layers and no resolution modeling; and 3) no physical DOI design but with a different number of virtual DOI layers. The image quality was quantitatively evaluated in terms of spatial resolution (full-width-half-maximum and position offset), contrast recovery coefficient and noise. The results indicate that the proposed method has the potential to be used as an alternative to other physical DOI designs and achieve comparable imaging performances, while reducing detector/system design cost and complexity.

Selenium contamination and remediation at Stewart Lake Waterfowl Management Area and Ashley Creek, middle Green River basin, Utah

USGS Publications Warehouse

Rowland, Ryan C.; Stephens, Doyle W.; Waddell, Bruce; Naftz, David L.

2003-01-01

Selenium is an element required in trace amounts for human and animal health, but it can cause health problems for livestock, wildlife, and humans when ingested in higher-than-required concentrations. Incidences of mortality, birth defects, and reproductive failure in waterfowl were discovered at Kesterson National Wildlife Refuge, San Joaquin Valley, California, by the U.S. Fish and Wildlife Service (USFWS) in 1983 (Presser, 1994). These problems were attributed to elevated concentrations of selenium in irrigation drainage that discharged to the refuge. Because of concern about possible adverse effects from irrigation drainage on Department of the Interior (DOI) projects elsewhere in the United States, the DOI organized scientists from the U.S. Geological Survey (USGS), USFWS, Bureau of Reclamation (BOR), and Bureau of Indian Affairs (BIA) to form the National Irrigation Water-Quality Program (NIWQP). The objectives of the program are to investigate DOI-managed lands for potential contamination related to irrigation drainage, conduct studies to identify the problems, investigate methodologies to remediate those problems, and implement remediation plans (U.S. Department of the Interior, 2002).

A method for assessing carbon stocks, carbon sequestration, and greenhouse-gas fluxes in ecosystems of the United States under present conditions and future scenarios

Treesearch

Zhiliang Zhu; Brian Bergamaschi; Richard Bernknopf; David Clow; Dennis Dye; Stephen Faulkner; William Forney; Robert Gleason; Todd Hawbaker; Jinxun Liu; Shuguang Liu; Stephen Prisley; Bradley Reed; Matthew Reeves; Matthew Rollins; Benjamin Sleeter; Terry Sohl; Sarah Stackpoole; Stephen Stehman; Robert Striegl; Anne Wein

2010-01-01

This methodology was developed to fulfill a requirement by the Energy Independence and Security Act of 2007 (EISA). The EISA legislation mandates the U.S. Department of the Interior (DOI) to develop a methodology and conduct an assessment of carbon storage, carbon sequestration, and fluxes of three principal greenhouse gases (GHG) for the Nation's ecosystems. The...

Areas Susceptible to Irrigation-Induced Selenium Contamination of Water and Biota in the Western United States

USGS Publications Warehouse

Seiler, Ralph L.; Skorupa, Joseph P.; Peltz, Lorri A.

1999-01-01

The U.S. Department of the Interior (DOI) studied contamination induced by irrigation drainage in 26 areas of the Western United States during 1986-95. Comprehensive compilation, synthesis, and evaluation of the data resulting from these studies were initiated by DOI in 1992. Soils and ground water in irrigated areas of the West can contain high concentrations of selenium because of (1) residual selenium from the soil's parent rock beneath irrigated land; (2) selenium derived from rocks in mountains upland from irrigated land by erosion and transport along local drainages, and (3) selenium brought into the area in surface water imported for irrigation. Application of irrigation water to seleniferous soils can dissolve and mobilize selenium and create hydraulic gradients that cause the discharge of seleniferous ground water into irrigation drains. Given a source of selenium, the magnitude of selenium contamination in drainage-affected aquatic ecosystems is strongly related to the aridity of the area and the presence of terminal lakes and ponds. Marine sedimentary rocks and deposits of Late Cretaceous or Tertiary age are generally seleniferous in the Western United States. Depending on their origin and history, some Tertiary continental sedimentary deposits also are seleniferous. Irrigation of areas associated with these rocks and deposits can result in concentrations of selenium in water that exceed criteria for the protection of freshwater aquatic life. Geologic and climatic data for the Western United States were evaluated and incorporated into a geographic information system (GIS) to produce a map identifying areas susceptible to irrigation-induced selenium contamination. Land is considered susceptible where a geologic source of selenium is in or near the area and where the evaporation rate is more than 2.5 times the precipitation rate. In the Western United States, about 160,000 square miles of land, which includes about 4,100 square miles (2.6 million acres) of land irrigated for agriculture, has been identified as being susceptible. Biological data were used to evaluate the reliability of the map. In 12 of DOl's 26 study areas, concentrations of selenium measured in bird eggs were elevated sufficiently to significantly reduce hatchability of the eggs. The GIS map identifies 9 of those 12 areas. Deformed bird embryos having classic symptoms of selenium toxicosis were found in four of the study areas, and the map identifies all four as susceptible to irrigation-induced selenium contamination.

Improving Simulations of Fine Dust Surface Concentrations over the Western United States by Optimizing the Particle Size Distribution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Li; Kok, Jasper F.; Henze, Daven

2013-06-28

To improve estimates of remote contributions of dust to fine particulate matter (PM2.5) in the western United States, new dust particle size distributions (PSDs) based upon scale-invariant fragmentation theory (Kok_PSD) with constraints from in situ measurements (IMP_PSD) are implemented in a chemical transport model (GEOS-Chem). Compared to initial simulations, this leads to reductions in the mass of emitted dust particles with radii <1.8 mm by 40%-60%. Consequently, the root-mean-square error in simulated fine dust concentrations compared to springtime surface observations in the western United States is reduced by 67%-81%. The ratio of simulated fine to coarse PM mass is alsomore » improved, which is not achievable by reductions in total dust emissions. The IMP_PSD best represents the PSD of dust transported from remote sources and reduces modeled PM2.5 concentrations up to 5 mg/m3 over the western United States, which is important when considering sources contributing to nonattainment of air quality standards. Citation: Zhang, L., J. F. Kok, D. K. Henze, Q. Li, and C. Zhao (2013), Improving simulations of fine dust surface concentrations over the western United States by optimizing the particle size distribution, Geophys. Res. Lett., 40, 3270-3275, doi:10.1002/grl.50591.« less

Alaska geology revealed

USGS Publications Warehouse

Wilson, Frederic H.; Labay, Keith A.

2016-11-09

This map shows the generalized geology of Alaska, which helps us to understand where potential mineral deposits and energy resources might be found, define ecosystems, and ultimately, teach us about the earth history of the State. Rock units are grouped in very broad categories on the basis of age and general rock type. A much more detailed and fully referenced presentation of the geology of Alaska is available in the Geologic Map of Alaska (http://dx.doi.org/10.3133/sim3340). This product represents the simplification of thousands of individual rock units into just 39 broad groups. Even with this generalization, the sheer complexity of Alaskan geology remains evident.

Hand-to-Hand Combat and the Use of Combatives Skills: An Analysis of United States Army Post Combat Surveys from 2004-2008

DTIC Science & Technology

2014-11-19

to develop virtual environments for practicing stress management skills with military personnel prior to deployment. Cyberpsychology , Behavior , and... Social Networking , 13, 83-94. doi: 10.1089=cyber.2009.0336 Bowen, G. A. (2009). Document analysis as a qualitative research method. Qualitative... Behavioral Science and Leadership, was very helpful in providing insight and advice as the project progressed. Matt Larsen, US Army (Retired), former

A chronosequence feasibility assessment of emergency fire rehabilitation records within the intermountain western United States-final report to the Joint Fire Science Program-Project 08-S-08

Treesearch

Kevin C. Knutson; David A. Pyke; Troy A. Wirth; David S. Pilliod; Matthew L. Brooks; Jeanne C. Chambers

2009-01-01

Department of the Interior (DOI) bureaus have invested heavily (for example, the U.S. Bureau of Land Management (BLM) spent more than $60 million in fiscal year 2007) in seeding vegetation for emergency stabilization and burned area rehabilitation of non-forested arid lands over the past 10 years. The primary objectives of these seedings commonly are to (1) reduce the...

Preparedness for the Evaluation and Management of Mass Casualty Incidents Involving Anticholinesterase Compounds: A Survey of Emergency Department Directors in the 12 Largest Cities in the United States

DTIC Science & Technology

2010-11-01

ORIGINAL ARTICLE Preparedness for the evaluation and management of mass casualty incidents involving anticholinesterase compounds: A survey of...Greenberg, MD, MPH Abstract Objectives: Anticholinesterases include carba- mate and organophosphorus (OP) insecticides and nerve agents. Release of...counterpart to REMM would be either moderately or very helpful for MCIs involving anticholinesterases . DOI:IO.5055/ajdm.2010.0035

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges.

PubMed

Alayed, Mrwan; Deen, M Jamal

2017-09-14

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system.

A spatial database of wildfires in the United States, 1992-2011

NASA Astrophysics Data System (ADS)

Short, K. C.

2013-07-01

The statistical analysis of wildfire activity is a critical component of national wildfire planning, operations, and research in the United States (US). However, there are multiple federal, state, and local entities with wildfire protection and reporting responsibilities in the US, and no single, unified system of wildfire record-keeping exists. To conduct even the most rudimentary interagency analyses of wildfire numbers and area burned from the authoritative systems of record, one must harvest records from dozens of disparate databases with inconsistent information content. The onus is then on the user to check for and purge redundant records of the same fire (i.e. multijurisdictional incidents with responses reported by several agencies or departments) after pooling data from different sources. Here we describe our efforts to acquire, standardize, error-check, compile, scrub, and evaluate the completeness of US federal, state, and local wildfire records from 1992-2011 for the national, interagency Fire Program Analysis (FPA) application. The resulting FPA Fire-occurrence Database (FPA FOD) includes nearly 1.6 million records from the 20 yr period, with values for at least the following core data elements: location at least as precise as a Public Land Survey System section (2.6 km2 grid), discovery date, and final fire size. The FPA FOD is publicly available from the Research Data Archive of the US Department of Agriculture, Forest Service (doi:10.2737/RDS-2013-0009). While necessarily incomplete in some aspects, the database is intended to facilitate fairly high-resolution geospatial analysis of US wildfire activity over the past two decades, based on available information from the authoritative systems of record.

A spatial database of wildfires in the United States, 1992-2011

NASA Astrophysics Data System (ADS)

Short, K. C.

2014-01-01

The statistical analysis of wildfire activity is a critical component of national wildfire planning, operations, and research in the United States (US). However, there are multiple federal, state, and local entities with wildfire protection and reporting responsibilities in the US, and no single, unified system of wildfire record keeping exists. To conduct even the most rudimentary interagency analyses of wildfire numbers and area burned from the authoritative systems of record, one must harvest records from dozens of disparate databases with inconsistent information content. The onus is then on the user to check for and purge redundant records of the same fire (i.e., multijurisdictional incidents with responses reported by several agencies or departments) after pooling data from different sources. Here we describe our efforts to acquire, standardize, error-check, compile, scrub, and evaluate the completeness of US federal, state, and local wildfire records from 1992-2011 for the national, interagency Fire Program Analysis (FPA) application. The resulting FPA Fire-Occurrence Database (FPA FOD) includes nearly 1.6 million records from the 20 yr period, with values for at least the following core data elements: location, at least as precise as a Public Land Survey System section (2.6 km2 grid), discovery date, and final fire size. The FPA FOD is publicly available from the Research Data Archive of the US Department of Agriculture, Forest Service (doi:10.2737/RDS-2013-0009). While necessarily incomplete in some aspects, the database is intended to facilitate fairly high-resolution geospatial analysis of US wildfire activity over the past two decades, based on available information from the authoritative systems of record.

Northern Prairie Wildlife Research Center

USGS Publications Warehouse

,

2009-01-01

The Northern Prairie Wildlife Research Center (NPWRC) conducts integrated research to fulfill the Department of the Interior's responsibilities to the Nation's natural resources. Located on 600 acres along the James River Valley near Jamestown, North Dakota, the NPWRC develops and disseminates scientific information needed to understand, conserve, and wisely manage the Nation's biological resources. Research emphasis is primarily on midcontinental plant and animal species and ecosystems of the United States. During the center's 40-year history, its scientists have earned an international reputation for leadership and expertise on the biology of waterfowl and grassland birds, wetland ecology and classification, mammalian behavior and ecology, grassland ecosystems, and application of statistics and geographic information systems. To address current science challenges, NPWRC scientists collaborate with researchers from other U.S. Geological Survey centers and disciplines (Biology, Geography, Geology, and Water) and with biologists and managers in the Department of the Interior (DOI), other Federal agencies, State agencies, universities, and nongovernmental organizations. Expanding upon its scientific expertise and leadership, the NPWRC is moving in new directions, including invasive plant species, restoration of native habitats, carbon sequestration and marketing, and ungulate management on DOI lands.

Remote sensing and geospatial support to burned area emergency response teams

USGS Publications Warehouse

McKinley, Randy; Clark, Jess

2011-01-01

A major concern of land managers in the United States is the response of watersheds to weather after a wildfire. With an ever-expanding wildland-urban interface (WUI), land managers must be cognizant of potential damage to private property and other values at risk. In the United States, land-management agencies from the U.S. Department of Agriculture (USDA) and the U.S. Department of the Interior (DOI) deploy Burned Area Emergency Response (BAER) teams to address these concerns and to “prescribe and implement emergency treatments to minimize threats to life or property or to stabilize and prevent unacceptable degradation to natural and cultural resources resulting from the effects of a fire” (USDA Forest Service 2004, p. 17). BAER teams’ objective is emergency stabilization of burned areas, rather than long-term restoration of the landscape after a fire.

Surveillance for Asian H5N1 avian influenza in the United States

USGS Publications Warehouse

Ip, Hon S.; Slota, Paul G.

2006-01-01

Increasing concern over the potential for migratory birds to introduce the Asian H5N1 strain of avian influenza to North America prompted the White House Policy Coordinating Committee for Pandemic Influenza Preparedness to request that the U.S. Departments of Agriculture (USDA) and Interior (DOI) develop a plan for the early detection of highly pathogenic avian influenza (HPAI) in the United States. To promote coordination among wildlife, agriculture, and human health agencies on HPAI surveillance efforts, the two Departments worked with representatives from the U.S. Department of Health and Human Services, the International Association of Fish and Wildlife Agencies, and the Alaska Department of Fish and Game to develop the U.S. Interagency Strategic Plan for Early Detection of Asian H5N1 Highly Pathogenic Avian Influenza in Wild Migratory Birds.

An overview and the latest status of the Landsat Data Continuity Mission (LDCM)

NASA Astrophysics Data System (ADS)

Sabelhaus, Phil

2011-10-01

The Landsat Data Continuity Mission (LDCM) will provide continuity in the multi-decadal land use/land cover change measurements of the Landsat Program for scientific research. The project office at the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) is responsible for the development, launch and post launch activation and check out for the Landsat Data Continuity Mission. The LDCM project is currently in its development phase with launch scheduled for December 2012 on an Atlas V launch vehicle provided by the Kennedy Space Center (KSC) from the Vandenberg Air Force Base (VAFB). The project is a partnership between NASA and the Department of the Interior (DOI)/United States Geological Survey (USGS). DOI/USGS is responsible for development of the ground system and will assume responsibility for satellite and ground system operations following the check-out period. This paper will provide an overview and the latest status of the LDCM mission.

Terrestrial ecosystems: national inventory of vegetation and land use

USGS Publications Warehouse

Gergely, Kevin J.; McKerrow, Alexa

2013-11-12

The Gap Analysis Program (GAP)/Landscape Fire and Resource Management Planning Tools (LANDFIRE) National Terrestrial Ecosystems Data represents detailed data on the vegetation and land-use patterns of the United States, including Alaska, Hawaii, and Puerto Rico. This national dataset combines detailed land cover data generated by the GAP with LANDFIRE data (http://www.landfire.gov/). LANDFIRE is an interagency vegetation, fire, and fuel characteristics mapping program sponsored by the U.S. Department of the Interior (DOI) and the U.S. Department of Agriculture Forest Service.

Confidence in the Efficacy and Safety of Dietary Supplements Among United States Active Duty Army Personnel

DTIC Science & Technology

2012-10-10

Alternative Medicine 2012, 12:182 doi:10.1186/1472-6882-12-182 Christina E Carvey (christina.carvey@us.army.mil) Emily K Farina (emily.k.farina@us.army.mil...www.biomedcentral.com/info/authors/ BMC Complementary and Alternative Medicine © 2012 Carvey et al. This is an open access article distributed under the terms of...U.S. Army Research Institute of Environmental Medicine ,Military Nutrition Division,Kansas Street, Natick,MA,01760 8. PERFORMING ORGANIZATION REPORT

STS-87 Mission Specialist Scott in white room

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Mission Specialist Winston Scott is assisted with his ascent and re-entry flight suit in the white room at Launch Pad 39B by Danny Wyatt, NASA quality assurance specialist. STS-87 is the fourth flight of the United States Microgravity Payload and Spartan-201. Scott is scheduled to perform an extravehicular activity spacewalk with Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, during STS-87. Scott also performed a spacewalk on the STS-72 mission.

KSC-97PC1707

NASA Image and Video Library

1997-11-19

STS-87 Mission Specialist Winston Scott is assisted with his ascent and re-entry flight suit in the white room at Launch Pad 39B by Danny Wyatt, NASA quality assurance specialist. STS-87 is the fourth flight of the United States Microgravity Payload and Spartan-201. Scott is scheduled to perform an extravehicular activity spacewalk with Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan, during STS-87. Scott also performed a spacewalk on the STS-72 mission

43 CFR 2.31 - How will DOI respond to my appeal?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false How will DOI respond to my appeal? 2.31... OF INFORMATION ACT FOIA Appeals § 2.31 How will DOI respond to my appeal? (a) Appeals will be decided... will state the basis for DOI's decision as follows: (1) Decision to release or withhold records. (i) If...

43 CFR 2.31 - How will DOI respond to my appeal?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false How will DOI respond to my appeal? 2.31... OF INFORMATION ACT FOIA Appeals § 2.31 How will DOI respond to my appeal? (a) Appeals will be decided... will state the basis for DOI's decision as follows: (1) Decision to release or withhold records. (i) If...

Time-Resolved Diffuse Optical Spectroscopy and Imaging Using Solid-State Detectors: Characteristics, Present Status, and Research Challenges

PubMed Central

Alayed, Mrwan

2017-01-01

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-invasive imaging modalities that have wide spread potential applications in many fields, particularly for structural and functional imaging in medicine. In this article, we review time-resolved diffuse optical imaging (TR-DOI) systems using solid-state detectors with a special focus on Single-Photon Avalanche Diodes (SPADs) and Silicon Photomultipliers (SiPMs). These TR-DOI systems can be categorized into two types based on the operation mode of the detector (free-running or time-gated). For the TR-DOI prototypes, the physical concepts, main components, figures-of-merit of detectors, and evaluation parameters are described. The performance of TR-DOI prototypes is evaluated according to the parameters used in common protocols to test DOI systems particularly basic instrumental performance (BIP). In addition, the potential features of SPADs and SiPMs to improve TR-DOI systems and expand their applications in the foreseeable future are discussed. Lastly, research challenges and future developments for TR-DOI are discussed for each component in the prototype separately and also for the entire system. PMID:28906462

Department of Interior Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... INTERIOR (DOI) DEPARTMENT OF THE INTERIOR Office of the Secretary 25 CFR Ch. I 30 CFR Chs. II and VII 36... Plugging and Platform Decommissioning 1010-AD61 Department of the Interior (DOI) Final Rule Stage United...-AX19 BILLING CODE 4310--55--S [[Page 21817

Operational air quality forecast guidance for the United States

NASA Astrophysics Data System (ADS)

Stajner, Ivanka; Lee, Pius; Tong, Daniel; Pan, Li; McQueen, Jeff; Huang, Jinaping; Djalalova, Irina; Wilczak, James; Huang, Ho-Chun; Wang, Jun; Stein, Ariel; Upadhayay, Sikchya

2016-04-01

NOAA provides operational air quality predictions for ozone and wildfire smoke over the United States (U.S.) and predictions of airborne dust over the contiguous 48 states at http://airquality.weather.gov. These predictions are produced using U.S. Environmental Protection Agency (EPA) Community Model for Air Quality (CMAQ) and NOAA's HYSPLIT model (Stein et al., 2015) with meteorological inputs from the North American Mesoscale Forecast System (NAM). The current efforts focus on improving test predictions of fine particulate matter (PM2.5) from CMAQ. Emission inputs for ozone and PM2.5 predictions include inventory information from the U.S. EPA and recently added contributions of particulate matter from intermittent wildfires and windblown dust that rely on near real-time information. Current testing includes refinement of the vertical grid structure in CMAQ and inclusion of contributions of dust transport from global sources into the U.S. domain using the NEMS Global Aerosol Capability (NGAC). The addition of wildfire smoke and dust contributions in CMAQ reduced model underestimation of PM2.5 in summertime. Wintertime overestimation of PM2.5 was reduced by suppressing emissions of soil particles when the terrain is covered by snow or ice. Nevertheless, seasonal biases and biases in the diurnal cycle of PM2.5 are still substantial. Therefore, a new bias correction procedure based on an analog ensemble approach was introduced (Djalalova et al., 2015). It virtually eliminates biases in monthly means or in the diurnal cycle, but it also reduces day-to-day variability in PM2.5 predictions. Refinements to the bias correction procedure are being developed. Upgrades for the representation of wildfire smoke emissions within the domain and from global sources are in testing. Another area of active development includes approaches to scale emission inventories for nitrogen oxides in order to reproduce recent changes observed by the AirNow surface monitoring network and by satellite instruments (Tong et al., 2015) and to use these updated emissions to improve ozone predictions (Pan et al., 2015). An overview of the impacts of these recent and ongoing efforts to improve predictions of ozone, smoke and PM2.5 will be presented. Djalalova, I. et al., 2015: PM2.5 analog forecast and Kalman filter post-processing for the Community Multiscale Air Quality (CMAQ) model. Atmospheric Environment, doi:10.1016/j.atmosenv.2015.05.057. Pan L. et al., 2014: Assessment of NOx and O3 forecasting performances in the U.S. National Air Quality Forecasting Capability before and after the 2012 major emissions updates. Atmospheric Environment, doi: 10.1016/j.atmosenv.2014.06.020. Stein, A. et al., 2015: NOAA's HYSPLIT atmospheric transport and dispersion modeling system. Bull. Amer. Meteor. Soc., doi:10.1175/BAMS-D-14-00110.1. Tong, D.Q. et al., 2015: Long-term NOx trends over large cities in the United States during the great recession: Comparison of satellite retrievals, ground observations, and emission inventories. Atmospheric Environment, doi:10.1016/j.atmosenv.2015.01.035.

Conceptual Design for the Amphibian Research and Monitoring Initiative (ARMI)

NASA Astrophysics Data System (ADS)

Battaglin, W. A.; Langtimm, C. A.; Adams, M. J.; Gallant, A. L.; James, D. L.

2001-12-01

In 2000, the President of the United States (US) and Congress directed Department of Interior (DOI) agencies to develop a program for monitoring trends in amphibian populations on DOI lands and to conduct research into causes of declines. The U.S. Geological Survey (USGS) was given lead responsibility for planning and implementing the Amphibian Research and Monitoring Initiative (ARMI) in cooperation with the National Park Service (NPS), Fish and Wildlife Service, and Bureau of Land Management. The program objectives are to (1) establish a network for monitoring the status and distribution of amphibian species on DOI lands; (2) identify and monitor environmental conditions known to affect amphibian populations; (3) conduct research on causes of amphibian population change and malformations; and (4) provide information to resource managers, policy makers, and the public in support of amphibian conservation. The ARMI program will integrate research efforts of USGS, other Federal, and non-federal herpetologists, hydrologists, and geographers across the Nation. ARMI will conduct a small number (~20) of intensive research efforts (for example, studies linking amphibian population changes to hydrologic conditions) and a larger number (~50) of more generalized inventory and monitoring studies encompassing broader areas such as NPS units. ARMI will coordinate with and try to augment other amphibian inventory studies such as the National Amphibian Atlas and the North American Amphibian Monitoring Program. ARMI will develop and test protocols for the standardized collection of amphibian data and provide a centrally managed database designed to simplify data entry, retrieval, and analysis. ARMI pilot projects are underway at locations across the US.

Proceedings of the third USGS modeling conference, June 7-11, 2010, Broomfield, Colorado-Understanding and predicting for a changing world

USGS Publications Warehouse

Brady, Shailaja R.

2011-01-01

The Third USGS Modeling Conference was held June 7th-11, 2010, in Broomfield, Colorado. The conference focused on the development and application of analytical and theoretical models and data availability that support managing the Nation's resources and help protect lives and property. Participants at the conference included scientists and managers from Department of the Interior (DOI) Bureaus; national and international Federal, State, and local agencies; academic institutions; and nongovernmental organizations. The conference was organized according to DOI priorities and the strategic directions of the USGS Science Strategy; the following themes were emphasized: (1) Understanding Ecosystems and Restoring America's Treasured Landscapes; (2) Climate Change and Impact; (3) New Energy Frontier and Minerals for America; (4) A National Hazards, Risk, and Resilience Assessment Program; (5) Role of Environment and Wildlife in Human Health; (6) A Water Census of the United States; and (7) New Methods of Investigation and Discovery. The conference theme-"Understanding and Predicting for a Changing World"-focused on the following goals: advance development and application of models; provide tools that address management issues; present state-of-the-art models ranging from individual phenomena to integrated systems; and foster a working community among scientists and managers.

Estimating State-Specific Contributions to PM2.5- and O3-Related Health Burden from Residential Combustion and Electricity Generating Unit Emissions in the United States.

PubMed

Penn, Stefani L; Arunachalam, Saravanan; Woody, Matthew; Heiger-Bernays, Wendy; Tripodis, Yorghos; Levy, Jonathan I

2017-03-01

Residential combustion (RC) and electricity generating unit (EGU) emissions adversely impact air quality and human health by increasing ambient concentrations of fine particulate matter (PM 2.5 ) and ozone (O 3 ). Studies to date have not isolated contributing emissions by state of origin (source-state), which is necessary for policy makers to determine efficient strategies to decrease health impacts. In this study, we aimed to estimate health impacts (premature mortalities) attributable to PM 2.5 and O 3 from RC and EGU emissions by precursor species, source sector, and source-state in the continental United States for 2005. We used the Community Multiscale Air Quality model employing the decoupled direct method to quantify changes in air quality and epidemiological evidence to determine concentration-response functions to calculate associated health impacts. We estimated 21,000 premature mortalities per year from EGU emissions, driven by sulfur dioxide emissions forming PM 2.5 . More than half of EGU health impacts are attributable to emissions from eight states with significant coal combustion and large downwind populations. We estimate 10,000 premature mortalities per year from RC emissions, driven by primary PM 2.5 emissions. States with large populations and significant residential wood combustion dominate RC health impacts. Annual mortality risk per thousand tons of precursor emissions (health damage functions) varied significantly across source-states for both source sectors and all precursor pollutants. Our findings reinforce the importance of pollutant-specific, location-specific, and source-specific models of health impacts in design of health-risk minimizing emissions control policies. Citation: Penn SL, Arunachalam S, Woody M, Heiger-Bernays W, Tripodis Y, Levy JI. 2017. Estimating state-specific contributions to PM 2.5 - and O 3 -related health burden from residential combustion and electricity generating unit emissions in the United States. Environ Health Perspect 125:324-332; http://dx.doi.org/10.1289/EHP550.

Results of the Phoenix Relative Humidity Sensor Recalibration

NASA Astrophysics Data System (ADS)

Martinez, G.; Fischer, E.; Renno, N. O.

2017-12-01

We show results of the recalibration of the Thermal and Electrical Conductivity Probe (TECP) relative humidity (RH) sensor of the Phoenix Mars lander [Zent et al., 2009]. Due to uncertainties in its pre-flight calibration, which partially overlapped the environmental conditions found at the Phoenix landing site [Tamppari et al., 2010], only the raw, unprocessed output of the TECP RH sensor is available in NASA's Planetary Data System (PDS). The sensor's calibration was revised in 2016 to correct for inaccuracies at the lowest temperatures [Zent et al., 2016], but the new processed RH values were not posted in the PDS. We have been using a spare engineering unit of the TECP to recalibrate the sensor in the full range of Phoenix landing site conditions in the Michigan Mars Environmental Chamber (MMEC) [Fischer et al., 2016]. We compare raw output data of the engineering unit in the MMEC with that of the flight unit from the preflight calibration. We observed that the engineering unit's RH sensor output was shifted to higher values compared to the flight unit's output at the same conditions of temperature and humidity. Based on this shift, we use a translation function that fits the in-situ measurements of the flight unit into the engineering unit output space. To improve the accuracy of this function, we use additional observations corresponding to saturated conditions when near-surface fog was observed [Whiteway et al., 2009], as well as observations around noon when the RH is expected to be below 5%. The entire range of conditions observed on the Martian surface is covered in our recalibration. The raw output of the sensor is used to obtain a new calibration function. This allows us to obtain high-level RH data at Martian polar conditions. The recalibrated data will be posted in the PDS. REFERENCES: Fischer, E., et al. (2016), Astrobiology, 16, 12, doi: 10.1089/ast.2016.1525. Tamppari, L. K., et al. (2010), J. Geophys. Res., 115, E00E17, doi:10.1029/2009JE003415. Whiteway, J. A., et al. (2009), Science, 325, 68, doi: 10.1126/science.1172344. Zent, A. P., et al. (2009), J. Geophys. Res., 114, E00A27, doi:10.1029/2007JE003052. Zent, A. P., et al. (2016), J. Geophys. Res. Planets, 121, 626-651, doi:10.1002/2015JE004933.

Space Shuttle STS-87 Columbia launch

NASA Technical Reports Server (NTRS)

1997-01-01

Like a rising sun lighting up the afternoon sky, the Space Shuttle Columbia (STS-87) soared from Launch Pad 39B on the fourth flight of the United States Microgravity Payload (USMP-4) and Spartan-201 satellite which were managed by scientists and engineers from the Marshall Space Flight Center. During the 16-day mission, the crew oversaw experiments in microgravity; deployed and retrieved a solar satellite; and tested a new experimental camera, the AERCam Sprint. Two crew members, Dr. Takao Doi and Winston Scott also performed a spacewalk to practice International Space Station maneuvers.

Practice Safe Driving.

PubMed

2017-07-01

More than 30,000 people die in motor vehicle collisions each year in the United States. Distracted, drowsy, and drunk driving cause most motor vehicle collision injuries and deaths. An editorial published in the October 2016 issue of JOSPT identified the global need for effective strategies to reduce, if not eliminate, preventable injuries, including whiplash-associated disorders and deaths from distracted driving. This is a call to action for everyone who gets behind the wheel of a car. J Orthop Sports Phys Ther 2017;47(7):449. doi:10.2519/jospt.2017.0506.

Interior Secretary Highlights Key Trends, Including Climate Change and Fiscal Constraint

NASA Astrophysics Data System (ADS)

Showstack, Randy

2014-06-01

Climate change is "the defining issue of our time," Department of the Interior (DOI) Secretary Sally Jewell said during her 18 June keynote addess at the AGU Science Policy Conference in Washington, D. C. The United States has to "lead by example. We can't be the largest economy in the world and the second largest producer of carbon in the world"—after China—"and not take care of our own problems first to demonstrate to the world what needs to be done," she said.

Persistent Identifiers for Field Expeditions: A Next Step for the US Oceanographic Research Fleet

NASA Astrophysics Data System (ADS)

Arko, Robert; Carbotte, Suzanne; Chandler, Cynthia; Smith, Shawn; Stocks, Karen

2016-04-01

Oceanographic research cruises are complex affairs, typically requiring an extensive effort to secure the funding, plan the experiment, and mobilize the field party. Yet cruises are not typically published online as first-class digital objects with persistent, citable identifiers linked to the scientific literature. The Rolling Deck to Repository (R2R; info@rvdata.us) program maintains a master catalog of oceanographic cruises for the United States research fleet, currently documenting over 6,000 expeditions on 37 active and retired vessels. In 2015, R2R started routinely publishing a Digital Object Identifier (DOI) for each completed cruise. Cruise DOIs, in turn, are linked to related persistent identifiers where available including the Open Researcher and Contributor ID (ORCID) for members of the science party, the International Geo Sample Number (IGSN) for physical specimens collected during the cruise, the Open Funder Registry (FundRef) codes that supported the experiment, and additional DOIs for datasets, journal articles, and other products resulting from the cruise. Publishing a persistent identifier for each field expedition will facilitate interoperability between the many different repositories that hold research products from cruises; will provide credit to the investigators who secured the funding and carried out the experiment; and will facilitate the gathering of fleet-wide altmetrics that demonstrate the broad impact of oceanographic research.

NASDA President Isao Uchida greets STS-87 Mission Specialist Takao Doi, Ph.D., after landing

NASA Technical Reports Server (NTRS)

1997-01-01

The president of the National Space Development Agency (NASDA) of Japan, Isao Uchida, at left, chats with STS-87 Mission Specialist Takao Doi, Ph.D., of NASDA, shortly after the landing of Columbia at Kennedy Space Center. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16-hour and 34- minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Commander Kevin Kregel; Pilot Steven Lindsey; Mission Specialists Winston Scott and Kalpana Chawla, Ph.D.; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

STS-87 M.S. Takao Doi, Ph.D., of NASDA after landing

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency (NASDA) of Japan greets a NASDA official shortly after the orbiter Columbia returned to KSC, touching down on Runway 33 at KSC's Shuttle Landing Facility. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, drawing the 15-day, 16-hour and 34-minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Commander Kevin Kregel; Pilot Steven Lindsey; Mission Specialists Winston Scott and Kalpana Chawla, Ph.D.; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

Spatial and temporal patterns of plantation forests in the United States since the 1930s: an annual and gridded data set for regional Earth system modeling

NASA Astrophysics Data System (ADS)

Chen, Guangsheng; Pan, Shufen; Hayes, Daniel J.; Tian, Hanqin

2017-08-01

Plantation forest area in the conterminous United States (CONUS) ranked second among the world's nations in the land area apportioned to forest plantation. As compared to the naturally regenerated forests, plantation forests demonstrate significant differences in biophysical characteristics, and biogeochemical and hydrological cycles as a result of more intensive management practices. Inventory data have been reported for multiple time periods on plot, state, and regional scales across the CONUS, but the requisite annual and spatially explicit plantation data set over a long-term period for analysis of the role of plantation management on regional or national scales is lacking. Through synthesis of multiple inventory data sources, this study developed methods to spatialize the time series plantation forest and tree species distribution data for the CONUS over the 1928-2012 time period. According to this new data set, plantation forest area increased from near zero in the 1930s to 268.27 thousand km2 in 2012, accounting for 8.65 % of the total forestland area in the CONUS. Regionally, the South contained the highest proportion of plantation forests, accounting for about 19.34 % of total forestland area in 2012. This time series and gridded data set developed here can be readily applied in regional Earth system modeling frameworks for assessing the impacts of plantation management practices on forest productivity, carbon and nitrogen stocks, and greenhouse gases (e.g., CO2, CH4, and N2O) and water fluxes on regional or national scales. The gridded plantation distribution and tree species maps, and the interpolated state-level annual tree planting area and plantation area during 1928-2012, are available from https://doi.org/10.1594/PANGAEA.873558.

Immunogenicity of Novel Mumps Vaccine Candidates Generated by Genetic Modification

PubMed Central

Xu, Pei; Chen, Zhenhai; Phan, Shannon; Pickar, Adrian

2014-01-01

Mumps is a highly contagious human disease, characterized by lateral or bilateral nonsuppurative swelling of the parotid glands and neurological complications that can result in aseptic meningitis or encephalitis. A mumps vaccination program implemented since the 1960s reduced mumps incidence by more than 99% and kept the mumps case numbers as low as hundreds of cases per year in the United States before 2006. However, a large mumps outbreak occurred in vaccinated populations in 2006 and again in 2009 in the United States, raising concerns about the efficacy of the vaccination program. Previously, we have shown that clinical isolate-based recombinant mumps viruses lacking expression of either the V protein (rMuVΔV) or the SH protein (rMuVΔSH) are attenuated in a neurovirulence test using newborn rat brains (P. Xu et al., Virology 417:126–136, 2011, http://dx.doi.org/10.1016/j.virol.2011.05.003; P. Xu et al., J. Virol. 86:1768–1776, 2012, http://dx.doi.org/10.1128/JVI.06019-11) and may be good candidates for vaccine development. In this study, we examined immunity induced by rMuVΔSH and rMuVΔV in mice. Furthermore, we generated recombinant mumps viruses lacking expression of both the V protein and the SH protein (rMuVΔSHΔV). Analysis of rMuVΔSHΔV indicated that it was stable in tissue culture cell lines. Importantly, rMuVΔSHΔV was immunogenic in mice, indicating that it is a promising candidate for mumps vaccine development. PMID:24352450

Immunogenicity of novel mumps vaccine candidates generated by genetic modification.

PubMed

Xu, Pei; Chen, Zhenhai; Phan, Shannon; Pickar, Adrian; He, Biao

2014-03-01

Mumps is a highly contagious human disease, characterized by lateral or bilateral nonsuppurative swelling of the parotid glands and neurological complications that can result in aseptic meningitis or encephalitis. A mumps vaccination program implemented since the 1960s reduced mumps incidence by more than 99% and kept the mumps case numbers as low as hundreds of cases per year in the United States before 2006. However, a large mumps outbreak occurred in vaccinated populations in 2006 and again in 2009 in the United States, raising concerns about the efficacy of the vaccination program. Previously, we have shown that clinical isolate-based recombinant mumps viruses lacking expression of either the V protein (rMuVΔV) or the SH protein (rMuVΔSH) are attenuated in a neurovirulence test using newborn rat brains (P. Xu et al., Virology 417:126-136, 2011, http://dx.doi.org/10.1016/j.virol.2011.05.003; P. Xu et al., J. Virol. 86:1768-1776, 2012, http://dx.doi.org/10.1128/JVI.06019-11) and may be good candidates for vaccine development. In this study, we examined immunity induced by rMuVΔSH and rMuVΔV in mice. Furthermore, we generated recombinant mumps viruses lacking expression of both the V protein and the SH protein (rMuVΔSHΔV). Analysis of rMuVΔSHΔV indicated that it was stable in tissue culture cell lines. Importantly, rMuVΔSHΔV was immunogenic in mice, indicating that it is a promising candidate for mumps vaccine development.

A novel single-ended readout depth-of-interaction PET detector fabricated using sub-surface laser engraving.

PubMed

Uchida, H; Sakai, T; Yamauchi, H; Hakamata, K; Shimizu, K; Yamashita, T

2016-09-21

We propose a novel scintillation detector design for positron emission tomography (PET), which has depth of interaction (DOI) capability and uses a single-ended readout scheme. The DOI detector contains a pair of crystal bars segmented using sub-surface laser engraving (SSLE). The two crystal bars are optically coupled to each other at their top segments and are coupled to two photo-sensors at their bottom segments. Initially, we evaluated the performance of different designs of single crystal bars coupled to photomultiplier tubes at both ends. We found that segmentation by SSLE results in superior performance compared to the conventional method. As the next step, we constructed a crystal unit composed of a 3  ×  3  ×  20 mm 3 crystal bar pair, with each bar containing four layers segmented using the SSLE. We measured the DOI performance by changing the optical conditions for the crystal unit. Based on the experimental results, we then assessed the detector performance in terms of the DOI capability by evaluating the position error, energy resolution, and light collection efficiency for various crystal unit designs with different bar sizes and a different number of layers (four to seven layers). DOI encoding with small position error was achieved for crystal units composed of a 3  ×  3  ×  20 mm 3 LYSO bar pair having up to seven layers, and with those composed of a 2  ×  2  ×  20 mm 3 LYSO bar pair having up to six layers. The energy resolution of the segment in the seven-layer 3  ×  3  ×  20 mm 3 crystal bar pair was 9.3%-15.5% for 662 keV gamma-rays, where the segments closer to the photo-sensors provided better energy resolution. SSLE provides high geometrical accuracy at low production cost due to the simplicity of the crystal assembly. Therefore, the proposed DOI detector is expected to be an attractive choice for practical small-bore PET systems dedicated to imaging of the brain, breast, and small animals.

75 FR 82061 - Notice To Amend an Existing System of Records; Privacy Act of 1974; as Amended

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... amended, the Department of the Interior (DOI) is issuing public notice of its intent to amend the Bureau... would require a contrary determination. The DOI will publish a revised notice if changes are made based... primary uses of the records are: (1) To provide the BLM, the DOI or state, local and tribal governments...

30 CFR 1229.121 - Recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

...). (b) The State must maintain in a confidential manner all data obtained from DOI sources or from payor or company sources under the delegation which have been deemed “confidential or proprietary” by DOI...

Development of a life-cycle fugitive methane emissions model utilizing device level emissions and activity factors

NASA Astrophysics Data System (ADS)

Englander, J.; Brandt, A. R.

2017-12-01

There has been numerous studies in quantifying the scale of fugitive emissions from across the natural gas value chain. These studies have typically focused on either specific types of equipment (such as valves) or on a single part of the life-cycle of natural gas production (such as gathering stations).1,2 However it has been demonstrated that average emissions factors are not sufficient for representing leaks in the natural gas system.3 In this work, we develop a robust estimate of fugitive emissions rates by incorporating all publicly available studies done at the component up to the process level. From these known studies, we create a database of leaks with normalized nomenclature from which leak estimates can be drawn from actual leak observations. From this database, and parameterized by meta-data such as location, scale of study, or placement in the life-cycle, we construct stochastic emissions factors specific for each process unit. This will be an integrated tool as part of the Oil production greenhouse gas estimator (OPGEE) as well as the Fugitive Emissions Abatement Simulation Toolkit (FEAST) models to enhances their treatment of venting and fugitive emissions, and will be flexible to include user provided data and input parameters.4,51. Thoma, ED et al. Assessment of Uinta Basin Oil and Natural Gas Well Pad Pneumatic Controller Emissions. J. Environ. Prot. 2017. 2. Marchese, AJ et al. Methane Emissions from United States Natural Gas Gathering and Processing. ES&T 2015. doi:10.1021/acs.est.5b02275 3. Brandt, AR et al. Methane Leaks from Natural Gas Systems Follow Extreme Distributions. ES&T 2016. doi:10.1021/acs.est.6b04303 4. El-Houjeiri, HM et al. An open-source LCA tool estimating greenhouse gas emissions from crude oil production using field characteristics. ES&T 2013. doi: 10.1021/es304570m 5. Kemp, CE et al. Comparing Natural Gas Leakage Detection Technologies Using an Open-Source `Virtual Gas Field' Simulator. ES&T 2016. doi:10.1021/acs.est.5b06068

Estimating State-Specific Contributions to PM2.5- and O3-Related Health Burden from Residential Combustion and Electricity Generating Unit Emissions in the United States

PubMed Central

Penn, Stefani L.; Arunachalam, Saravanan; Woody, Matthew; Heiger-Bernays, Wendy; Tripodis, Yorghos; Levy, Jonathan I.

2016-01-01

Background: Residential combustion (RC) and electricity generating unit (EGU) emissions adversely impact air quality and human health by increasing ambient concentrations of fine particulate matter (PM2.5) and ozone (O3). Studies to date have not isolated contributing emissions by state of origin (source-state), which is necessary for policy makers to determine efficient strategies to decrease health impacts. Objectives: In this study, we aimed to estimate health impacts (premature mortalities) attributable to PM2.5 and O3 from RC and EGU emissions by precursor species, source sector, and source-state in the continental United States for 2005. Methods: We used the Community Multiscale Air Quality model employing the decoupled direct method to quantify changes in air quality and epidemiological evidence to determine concentration–response functions to calculate associated health impacts. Results: We estimated 21,000 premature mortalities per year from EGU emissions, driven by sulfur dioxide emissions forming PM2.5. More than half of EGU health impacts are attributable to emissions from eight states with significant coal combustion and large downwind populations. We estimate 10,000 premature mortalities per year from RC emissions, driven by primary PM2.5 emissions. States with large populations and significant residential wood combustion dominate RC health impacts. Annual mortality risk per thousand tons of precursor emissions (health damage functions) varied significantly across source-states for both source sectors and all precursor pollutants. Conclusions: Our findings reinforce the importance of pollutant-specific, location-specific, and source-specific models of health impacts in design of health-risk minimizing emissions control policies. Citation: Penn SL, Arunachalam S, Woody M, Heiger-Bernays W, Tripodis Y, Levy JI. 2017. Estimating state-specific contributions to PM2.5- and O3-related health burden from residential combustion and electricity generating unit emissions in the United States. Environ Health Perspect 125:324–332; http://dx.doi.org/10.1289/EHP550 PMID:27586513

Overview of Performance Based Practical Design

DOT National Transportation Integrated Search

2018-03-01

DOI: https://doi.org/10.13023/KTC.RR.2018.03 State transportation agencies (STAs) have increasingly turned to practical design and performance based practical design(PBPD) to inform project development and implementation and to reduce project cos...

The hallucinogen DOI reduces low-frequency oscillations in rat prefrontal cortex: reversal by antipsychotic drugs.

PubMed

Celada, Pau; Puig, M Victoria; Díaz-Mataix, Llorenç; Artigas, Francesc

2008-09-01

Perceptual and psychic alterations and thought disorder are fundamental elements of schizophrenia symptoms, a pathology associated with an abnormal macro- and microcircuitry of several brain areas including the prefrontal cortex (PFC). Alterations in information processing in PFC may partly underlie schizophrenia symptoms. The 5-HT(2A/2C) agonist DOI and antipsychotic drugs were administered to anesthetized rats. Single unit and local field potential (LFP) extracellular recordings were made in medial PFC (mPFC). Electrolytic lesions were performed in the thalamic nuclei. DOI markedly disrupts cellular and network activity in rat PFC. DOI altered pyramidal discharge in mPFC (39% excited, 27% inhibited, 34% unaffected; n = 51). In all instances, DOI concurrently reduced low-frequency oscillations (.3-4 Hz; power spectrum: .25 +/- .02 and .14 +/- .01 microV(2) in basal conditions and after 50-300 microg/kg intravenous (i.v.) DOI, respectively; n = 51). Moreover, DOI disrupted the temporal association between the active phase of LFP and pyramidal discharge. Both effects were reversed by M100907 (5-HT(2A) receptor antagonist) and were not attenuated by thalamic lesions, supporting an intracortical origin of the effects of DOI. The reduction in low-frequency oscillations induced by DOI was significantly reversed by the antipsychotic drugs haloperidol (.1-.2 mg/kg i.v.) and clozapine (1 mg/kg i.v.). DOI disorganizes network activity in PFC, reducing low-frequency oscillations and desynchronizing pyramidal discharge from active phases of LFP. These effects may underlie DOI's psychotomimetic action. The reversal by clozapine and haloperidol indicates that antipsychotic drugs may reduce psychotic symptoms by normalizing an altered PFC function.

Drought Risk and Adaptation in the Interior (DRAI)

NASA Astrophysics Data System (ADS)

McNeeley, S.; Ojima, D. S.

2013-12-01

Drought is part of the normal climate variability in the Great Plains and Intermountain Western United States, but recent severe droughts along with climate change projections have increased the interest and need for better understanding of drought science and decision making. The purpose of this study is to understand how the U.S. Department of the Interior's (DOI) federal land and resource managers and their stakeholders (i.e., National Park Service, Bureau of Land Management, Fish and Wildlife Service, Bureau of Reclamation, Bureau of Indian Affairs and tribes, among others) are experiencing and dealing with drought in their landscapes. The Drought Risk and Adaptation in the Interior (DRAI) project is part of a new DOI-sponsored North Central Climate Science Center (NC CSC) crosscutting science initiative on drought across the Center's three foundational science areas: 1. physical climate, 2. ecosystems impacts and responses, and 3. human adaptation and decision making. The overarching goal is to learn more about drought within the DOI public lands and resource management in order to contribute to both the NC CSC regional science as well as providing managers and other decision makers with the most salient, credible, and legitimate research to support land and resource management decisions. Here we will present the project approach along with some initial insights learned from the research to date along with its utility for climate adaptation.

The CAMELS data set: catchment attributes and meteorology for large-sample studies

NASA Astrophysics Data System (ADS)

Addor, Nans; Newman, Andrew J.; Mizukami, Naoki; Clark, Martyn P.

2017-10-01

We present a new data set of attributes for 671 catchments in the contiguous United States (CONUS) minimally impacted by human activities. This complements the daily time series of meteorological forcing and streamflow provided by Newman et al. (2015b). To produce this extension, we synthesized diverse and complementary data sets to describe six main classes of attributes at the catchment scale: topography, climate, streamflow, land cover, soil, and geology. The spatial variations among basins over the CONUS are discussed and compared using a series of maps. The large number of catchments, combined with the diversity of the attributes we extracted, makes this new data set well suited for large-sample studies and comparative hydrology. In comparison to the similar Model Parameter Estimation Experiment (MOPEX) data set, this data set relies on more recent data, it covers a wider range of attributes, and its catchments are more evenly distributed across the CONUS. This study also involves assessments of the limitations of the source data sets used to compute catchment attributes, as well as detailed descriptions of how the attributes were computed. The hydrometeorological time series provided by Newman et al. (2015b, https://doi.org/10.5065/D6MW2F4D) together with the catchment attributes introduced in this paper (https://doi.org/10.5065/D6G73C3Q) constitute the freely available CAMELS data set, which stands for Catchment Attributes and MEteorology for Large-sample Studies.

National Unmanned Aircraft Systems Project Office

USGS Publications Warehouse

Goplen, Susan E.; Sloan, Jeff L.

2015-01-01

The U.S. Geological Survey (USGS) National Unmanned Aircraft Systems (UAS) Project Office leads the implementation of UAS technology in the Department of the Interior (DOI). Our mission is to support the transition of UAS into DOI as a new cost-effective tool for collecting remote-sensing data to monitor environmental conditions, respond to natural hazards, recognize the consequences and benefits of land and climate change and conduct wildlife inventories. The USGS is teaming with all DOI agencies and academia as well as local, State, and Tribal governments with guidance from the Federal Aviation Administration and the DOI Office of Aviation Services (OAS) to lead the safe, efficient, costeffective and leading-edge adoption of UAS technology into the scientific research and operational activities of the DOI.

Unmanned aircraft systems (UAS) activities at the Department of the Interior

USGS Publications Warehouse

Quirk, Bruce K.; Hutt, Michael E.

2014-01-01

The U.S. Department of the Interior (DOI) is responsible for protecting and managing the natural resources and heritage on almost 20% of the land in the United States. The DOI’s mission requires access to remotely sensed data over vast lands, including areas that are remote and potentially dangerous to access. Unmanned Aircraft Systems (UAS) technology has the potential to enable the DOI to be a better steward of the land by: (1) Improving natural hazard forecasting and the analysis of the impacts. (2) Improving the understanding of climate change to better plan for likely impacts. (3) Developing precipitation and evaporation forecasting to better manage water resources. (4) Monitoring Arctic ice change and its impacts on ecosystems, coasts, and transportation. (5) Increasing safety and effectiveness of wildland fire management. (6) Enhancing search and rescue capabilities. (7) Broadening the abilities to monitor environmental or landscape conditions and changes. (8) Better understanding and protecting the Nation’s ecosystems. The initial operational testing and evaluations performed by the DOI have proven that UAS technology can be used to support many of the Department’s activities. UAS technology provides scientists a way to look longer, closer and more frequently at some of Earth’s most remote areas—places that were previously too dangerous or expensive to monitor in detail. The flexibility of operations and relative low cost to purchase and operate Small Unmanned Aerial System (sUAS) enhances the ability to track long-term landscape and environmental change. The initial testing indicates the operational costs are approximately 10% of traditional manned aircraft. In addition, users can quickly assess landscape-altering events such as wildland fires, floods and volcanoes. UAS technology will allow the DOI to do more with less and in the process enhance the Department’s ability to provide unbiased scientific information to help stakeholders make informed decisions. It will also provide a digital baseline record that can be archived and used when monitoring future events or conditions. One possible future scenario has scientists carrying sUAS into the field allowing quick deployment and operation to observe the environment or for emergency response. This scenario could also include a persistent monitoring capability provided by a UAS that can stay airborne over a small geographic area for days or weeks, or possibly longer. While the DOI focus is on sUAS, the Department recognizes that larger UAS systems will also play a role in meeting its mission. The Department anticipates meeting long-duration or specialized acquisition commitments, such as state or national aerial photography, by collaboration with other agencies or through commercial contracts. Even though the DOI continues to evaluate UAS and sensor technology to meet the Department’s mission, some of its bureaus are already moving towards an operational capability. The authors fully anticipate that by 2020 UAS will emerge as one of the primary platforms for DOI remote sensing applications.

The Wetland and Aquatic Research Center strategic science plan

USGS Publications Warehouse

,

2017-02-02

IntroductionThe U.S. Geological Survey (USGS) Wetland and Aquatic Research Center (WARC) has two primary locations (Gainesville, Florida, and Lafayette, Louisiana) and field stations throughout the southeastern United States and Caribbean. WARC’s roots are in U.S. Fish and Wildlife Service (USFWS) and National Park Service research units that were brought into the USGS as the Biological Research Division in 1996. Founded in 2015, WARC was created from the merger of two long-standing USGS biology science Centers—the Southeast Ecological Science Center and the National Wetlands Research Center—to bring together expertise in biology, ecology, landscape science, geospatial applications, and decision support in order to address issues nationally and internationally. WARC scientists apply their expertise to a variety of wetland and aquatic research and monitoring issues that require coordinated, integrated efforts to better understand natural environments. By increasing basic understanding of the biology of important species and broader ecological and physiological processes, this research provides information to policymakers and aids managers in their stewardship of natural resources and in regulatory functions.This strategic science plan (SSP) was developed to guide WARC research during the next 5–10 years in support of Department of the Interior (DOI) partnering bureaus such as the USFWS, the National Park Service, and the Bureau of Ocean Energy Management, as well as other Federal, State, and local natural resource management agencies. The SSP demonstrates the alignment of the WARC goals with the USGS mission areas, associated programs, and other DOI initiatives. The SSP is necessary for workforce planning and, as such, will be used as a guide for future needs for personnel. The SSP also will be instrumental in developing internal funding priorities and in promoting WARC’s capabilities to both external cooperators and other groups within the USGS.

Observations of the atmosphere and surface state over Terra Nova Bay, Antarctica using unmanned aircraft systems

NASA Astrophysics Data System (ADS)

Cassano, J. J.; Seefeldt, M. W.; Palo, S.; Knuth, S. L.; Bradley, A. C.; Herrman, P. D.; Kernebone, P. A.; Logan, N. J.

2015-12-01

In September 2012 five Aerosonde unmanned aircraft were used to make measurements of the atmospheric state over the Terra Nova Bay polynya, Antarctica, to explore the details of air - sea ice - ocean coupling. A total of 14 flights were completed in September 2012. Ten of the flight missions consisted of two unmanned aircraft systems (UAS) sampling the atmosphere over Terra Nova Bay on five different days, with one UAS focusing on the downwind evolution of the air mass and a second UAS flying transects roughly perpendicular to the low level winds. The data from these coordinated UAS flights provide a comprehensive three-dimensional data set of the atmospheric state (air temperature, humidity, pressure, and wind) and surface skin temperature over Terra Nova Bay. The remaining UAS flights during the September 2012 field campaign included two local flights near McMurdo Station for flight testing, a single UAS flight to Terra Nova Bay, and a single UAS flight over the Ross Ice Shelf and Ross Sea polynya. A dataset containing the atmospheric and surface data as well as operational aircraft data has been submitted to the United States Antarctic Program Data Coordination Center (USAP-DCC, http://www.usap-data.org/) for free access (http://gcmd.nasa.gov/getdif.htm?NSF-ANT10-43657, doi:10.15784/600125).

Realisation of all 16 Boolean logic functions in a single magnetoresistance memory cell

NASA Astrophysics Data System (ADS)

Gao, Shuang; Yang, Guang; Cui, Bin; Wang, Shouguo; Zeng, Fei; Song, Cheng; Pan, Feng

2016-06-01

Stateful logic circuits based on next-generation nonvolatile memories, such as magnetoresistance random access memory (MRAM), promise to break the long-standing von Neumann bottleneck in state-of-the-art data processing devices. For the successful commercialisation of stateful logic circuits, a critical step is realizing the best use of a single memory cell to perform logic functions. In this work, we propose a method for implementing all 16 Boolean logic functions in a single MRAM cell, namely a magnetoresistance (MR) unit. Based on our experimental results, we conclude that this method is applicable to any MR unit with a double-hump-like hysteresis loop, especially pseudo-spin-valve magnetic tunnel junctions with a high MR ratio. Moreover, after simply reversing the correspondence between voltage signals and output logic values, this method could also be applicable to any MR unit with a double-pit-like hysteresis loop. These results may provide a helpful solution for the final commercialisation of MRAM-based stateful logic circuits in the near future.Stateful logic circuits based on next-generation nonvolatile memories, such as magnetoresistance random access memory (MRAM), promise to break the long-standing von Neumann bottleneck in state-of-the-art data processing devices. For the successful commercialisation of stateful logic circuits, a critical step is realizing the best use of a single memory cell to perform logic functions. In this work, we propose a method for implementing all 16 Boolean logic functions in a single MRAM cell, namely a magnetoresistance (MR) unit. Based on our experimental results, we conclude that this method is applicable to any MR unit with a double-hump-like hysteresis loop, especially pseudo-spin-valve magnetic tunnel junctions with a high MR ratio. Moreover, after simply reversing the correspondence between voltage signals and output logic values, this method could also be applicable to any MR unit with a double-pit-like hysteresis loop. These results may provide a helpful solution for the final commercialisation of MRAM-based stateful logic circuits in the near future. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr03169b

NASDA President Isao Uchida shakes hands with STS-87 Mission Specialist Takao Doi, Ph.D., after land

NASA Technical Reports Server (NTRS)

1997-01-01

The president of the National Space Development Agency (NASDA) of Japan, Isao Uchida, at left, shakes hands with STS-87 Mission Specialist Takao Doi, Ph.D., of NASDA, shortly after the landing of Columbia at Kennedy Space Center. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16-hour and 34-minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Commander Kevin Kregel; Pilot Steven Lindsey; Mission Specialists Winston Scott and Kalpana Chawla, Ph.D.; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

Scott and Doi conduct tool evaluations during second EVA of STS-87

NASA Image and Video Library

1997-12-03

STS087-341-004 (3 Dec. 1997) --- Backdropped over Africa, Takao Doi, international mission specialist representing Japan’s National Space Development Agency (NASDA), works with a crane device during a second extravehicular activity (EVA) designed to help evaluate techniques and hardware to be used in constructing the International Space Station (ISS). Takao Doi and astronaut Winston E. Scott (out of frame) were involved in the mission's second EVA in the cargo bay of the Earth-orbiting Space Shuttle Columbia. Takao Doi is working with a 156-pound crane designed to aid spacewalkers in transporting Orbital Replacement Units (ORU) from translation carts on the exterior of the ISS to various worksites on the truss structure. The view of Earth below features an inland delta in Mali (frame center). This view is from the east toward the west and was taken with a 35mm camera.

Estimating snow water equivalent from GPS vertical site-position observations in the western United States

PubMed Central

Ouellette, Karli J; de Linage, Caroline; Famiglietti, James S

2013-01-01

[1] Accurate estimation of the characteristics of the winter snowpack is crucial for prediction of available water supply, flooding, and climate feedbacks. Remote sensing of snow has been most successful for quantifying the spatial extent of the snowpack, although satellite estimation of snow water equivalent (SWE), fractional snow covered area, and snow depth is improving. Here we show that GPS observations of vertical land surface loading reveal seasonal responses of the land surface to the total weight of snow, providing information about the stored SWE. We demonstrate that the seasonal signal in Scripps Orbit and Permanent Array Center (SOPAC) GPS vertical land surface position time series at six locations in the western United States is driven by elastic loading of the crust by the snowpack. GPS observations of land surface deformation are then used to predict the water load as a function of time at each location of interest and compared for validation to nearby Snowpack Telemetry observations of SWE. Estimates of soil moisture are included in the analysis and result in considerable improvement in the prediction of SWE. Citation: Ouellette, K. J., C. de Linage, and J. S. Famiglietti (2013), Estimating snow water equivalent from GPS vertical site-position observations in the western United States, Water Resour. Res., 49, 2508–2518, doi:10.1002/wrcr.20173. PMID:24223442

The Messinian evaporites in the Levant Basin: lithology, deformation and its evolution

NASA Astrophysics Data System (ADS)

Feng, Ye; Steinberg, Josh; Reshef, Moshe

2017-04-01

The lithological composition of the Messinian evaporite in the Levant Basin remains controversial and salt deformation mechanisms are still not fully understood, due to the lack of high resolution 3D depth seismic data and well logs that record the entire evaporite sequence. We demonstrate how 3D Pre-stack depth migration (PSDM) and intra-salt tomography can lead to improved salt imaging. Using 3D PSDM seismic data with great coverage and deepwater well log data from recently drilled boreholes, we reveal intra-salt reflective units associated with thin clastic layers and a seismic transparent background consisting of uniform pure halite. Structural maps of all internal reflectors are generated for stratigraphy and attributes analysis. High amplitude fan structures in the lowermost intra-salt reflector are observed, which may indicate the source of the clastic formation during the Messinian Salinity Crisis (MSC). The Messinian evaporite in the Levant Basin comprises six units; the uppermost unit thickens towards the northwest, whereas the other units are uniform in thickness. The top of salt (TS) horizon is relatively horizontal, while all other intra-salt reflectors and base of salt (BS) dip towards the northwest. Different seismic attributes are used for identification of intra-salt deformation patterns. Maximum curvature maps show NW-striking thrust faults on the TS and upper intra-salt units, and dip azimuth maps are used to show different fold orientations between the TS and intra-salt units, which indicate a two-phase deformation mechanism: basin NW tilting as syn-depositional phase and NNE spreading of Plio-Pleistocene overburden as post-depositional phase. RMS amplitude maps are used to identify a channelized system on the TS. An evaporite evolution model during the MSC of the Levant Basin is therefore established based on all the observations. Finally the mechanical properties of the salts will be utilized to explore salt deformation in the Levant Basin. Feng, Y. E., & Reshef, M. (2016). The Eastern Mediterranean Messinian salt-depth imaging and velocity analysis considerations. Petroleum Geoscience, 22(4), 2-19. doi:http://dx.doi.org/10.1144/petgeo2015-088 Feng, Y. E., Yankelzon, A., Steinberg, J., & Reshef, M. (2016). Lithology and characteristics of the Messinian evaporite sequence of the deep Levant Basin, eastern Mediterranean. Marine Geology, 376, 118-131. doi:http://dx.doi.org/10.1016/j.margeo.2016.04.004

The Association between Dust Storms and Daily Non-Accidental Mortality in the United States, 1993-2005.

PubMed

Crooks, James Lewis; Cascio, Wayne E; Percy, Madelyn S; Reyes, Jeanette; Neas, Lucas M; Hilborn, Elizabeth D

2016-11-01

The impact of dust storms on human health has been studied in the context of Asian, Saharan, Arabian, and Australian storms, but there has been no recent population-level epidemiological research on the dust storms in North America. The relevance of dust storms to public health is likely to increase as extreme weather events are predicted to become more frequent with anticipated changes in climate through the 21st century. We examined the association between dust storms and county-level non-accidental mortality in the United States from 1993 through 2005. Dust storm incidence data, including date and approximate location, are taken from the U.S. National Weather Service storm database. County-level mortality data for the years 1993-2005 were acquired from the National Center for Health Statistics. Distributed lag conditional logistic regression models under a time-stratified case-crossover design were used to study the relationship between dust storms and daily mortality counts over the whole United States and in Arizona and California specifically. End points included total non-accidental mortality and three mortality subgroups (cardiovascular, respiratory, and other non-accidental). We estimated that for the United States as a whole, total non-accidental mortality increased by 7.4% (95% CI: 1.6, 13.5; p = 0.011) and 6.7% (95% CI: 1.1, 12.6; p = 0.018) at 2- and 3-day lags, respectively, and by an average of 2.7% (95% CI: 0.4, 5.1; p = 0.023) over lags 0-5 compared with referent days. Significant associations with non-accidental mortality were estimated for California (lag 2 and 0-5 day) and Arizona (lag 3), for cardiovascular mortality in the United States (lag 2) and Arizona (lag 3), and for other non-accidental mortality in California (lags 1-3 and 0-5). Dust storms are associated with increases in lagged non-accidental and cardiovascular mortality. Citation: Crooks JL, Cascio WE, Percy MS, Reyes J, Neas LM, Hilborn ED. 2016. The association between dust storms and daily non-accidental mortality in the United States, 1993-2005. Environ Health Perspect 124:1735-1743; http://dx.doi.org/10.1289/EHP216.

Online Serum PFOA Calculator for Adults

PubMed Central

2017-01-01

Summary: Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that has been detected in >100 public water systems in the United States alone. A variety of epidemiological investigations of PFOA have been published, mostly using measured or modeled serum PFOA concentrations as the exposure metric. Comparison of drinking water PFOA concentrations to those study findings or to typical serum concentrations requires pharmacokinetic modeling. This brief communication describes an online Javascript calculator that easily plots the expected serum PFOA concentration over time and at steady state for adults after starting or stopping consumption of PFOA-contaminated water. Two examples of usage are provided, including increasing serum PFOA after ongoing consumption of contaminated water at the federal limit, and decreasing serum PFOA after carbon filtration began in a contaminated water system. https://doi.org/10.1289/EHP2820 PMID:29068316

Biomarker Levels of Toxic Metals among Asian Populations in the United States: NHANES 2011-2012.

PubMed

Awata, Hiroshi; Linder, Stephen; Mitchell, Laura E; Delclos, George L

2017-03-01

The Centers for Disease Control and Prevention (CDC) recently found that Asians have considerably higher biomarker levels of cadmium, lead, mercury, and arsenic than whites, blacks, Mexican Americans, and other Hispanics in the United States. Our goal was to further evaluate the higher metal biomarker levels among Asians. Biomarker data (blood cadmium, blood lead, blood mercury, urinary total arsenic, and urinary dimethylarsinic acic) from individuals ≥ 6 years of age were obtained from the 2011-2012 National Health and Nutrition Examination Survey (NHANES). We compared geometric mean levels of these five metal biomarkers in Asians with those of four other NHANES race/ethnic groups (white, black, Mexican American, and other Hispanic), and across three Asian subgroups (Chinese, Asian Indian, and other Asian). We also evaluated associations between biomarker levels and sociodemographic, physical, dietary, and behavioral covariates across the Asian subgroups. Asians had significantly higher levels of all five metal biomarkers than other race/ethnic groups ( p < 0.05), regardless of sociodemographic, physical, dietary, behavioral, or geographic characteristics. We also found variations in biomarker levels across the Asian subgroups. In general, Asian Indians had lower levels than the other two Asian subgroups, except for blood lead. The following characteristics were found to be significant predictors of several biomarker levels: sex, age, education, birthplace, smoking, and fish consumption. Overall, the Asian group had the highest geometric mean biomarker levels for all of the five metal variables. Furthermore, we provided evidence that significant variations in the biomarker levels are present across the Asian subgroups in the United States. Citation: Awata H, Linder S, Mitchell LE, Delclos GL. 2017. Biomarker levels of toxic metals among Asian populations in the United States: NHANES 2011-2012. Environ Health Perspect 125:306-313; http://dx.doi.org/10.1289/EHP27.

Noble Gas Plasmas with Metallic Conductivity: A New Light Source from a New State of Matter

DTIC Science & Technology

2015-11-01

light, Applied Physics Letters, (12 2014): 223501. doi: A. Bataller, B. Kappus , C. Camara, S. Putterman. Collision Time Measurements in a...Plasma Extremes Seen through Gas Bubble, Physics, (07 2014): 0. doi: 10.1103/Physics.7.72 A. Bataller, G.?R. Plateau, B. Kappus , S. Putterman

Industry disputes administration report on oil and gas leasing

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-05-01

Despite the Obama administration's efforts to make millions of acres of public lands available for oil and gas development, most of the acreage onshore and offshore of the contiguous United States remains idle, according to “Oil and gas lease utilization, onshore and offshore,” a 15 May report issued by the Department of the Interior (DOI). The report, which is being disputed by industry representatives, notes that 72% of the nearly 36 million leased offshore acres currently are inactive and that 50.6% of onshore leased acres (about 20.8 million acres) also are idle. “As part of the Obama administration's all-of- the-above energy strategy, we continue to make millions of acres of public lands available for safe and responsible domestic energy production on public lands and in federal waters,” said DOI secretary Ken Salazar. “These lands and waters belong to the American people, and they expect those energy supplies to be developed in a timely and responsible manner and with a fair return to taxpayers. We will continue to encourage companies to diligently bring production online quickly and safely on public lands already under lease.”

Sound Velocities of Iron-Nickel and Iron-Nickel-Silicon Alloys at High Pressure

NASA Astrophysics Data System (ADS)

Miller, R. A.; Jackson, J. M.; Sturhahn, W.; Zhao, J.; Murphy, C. A.

2014-12-01

Seismological and cosmochemical studies suggest Earth's core is primarily composed of iron with ~5 to 10 wt% nickel and some light elements [e.g. 1]. To date, the concentration of nickel and the amount and identity of light elements remain poorly constrained due in part to the difficulty of conducting experimental measurements at core conditions. The vibrational properties of a variety iron alloys paired with seismic observations can help better constrain the composition of the core. We directly measured the partial phonon density of states of bcc- and hcp-structured Fe0.9Ni0.1 and Fe0.85Ni0.1Si0.05 at high pressures. The samples were compressed using a panoramic diamond anvil cell. A subset of the experiments were conducted using neon as a pressure transmitting medium. Measurements of high statistical quality were performed with nuclear resonant inelastic x-ray scattering (NRIXS) at sector 3-ID-B of the Advanced Photon Source [2, 3, 4]. The unit cell volume of each sample was determined at each compression point with in-situ x-ray diffraction at sector 3-ID-B before and after each NRIXS measurement. The Debye, compressional, and shear sound velocities were determined from the low energy region of the partial phonon density of states paired with the volume measurements. We will present partial phonon density of states and sound velocities for Fe0.9Ni0.1 and Fe0.85Ni0.1Si0.05 at high-pressure and compare with those of pure iron. References: [1] McDonough, W.F. (2004): Compositional Model for the Earth's Core. Elsevier Ltd., Oxford. [2] Murphy, C.A., J.M. Jackson, W. Sturhahn, and B. Chen (2011): Melting and thermal pressure of hcp-Fe from the phonon density of states, Phys. Earth Planet. Int., doi:10.1016/j.pepi.2011.07.001. [3] Murphy, C.A., J.M. Jackson, W. Sturhahn, and B. Chen (2011): Grüneisen parameter of hcp-Fe to 171 GPa, Geophys. Res. Lett., doi:10.1029/2011GL049531. [4] Murphy, C.A., J.M. Jackson, and W. Sturhahn (2013): Experimental constraints on the thermodynamics and sound velocities of hcp-Fe to core pressures, J. Geophys. Res., doi:10.1002/jgrb.50166.

Retraction Statement: "High-Volumetric Performance Aligned Nano-Porous Microwave Exfoliated Graphite Oxide-based Electrochemical Capacitors" and "Aligned Nano-Porous Microwave Exfoliated Graphite Oxide Ionic Actuators with High Strain and Elastic Energy Density".

PubMed

2016-11-01

These articles first published on 15 August 2013 and 21 August 2013 on the Wiley Online Library have been retracted at the request of the Research Integrity Officer (RIO) of The Pennsylvania State University, in agreement with the corresponding authors, the journal's Editor-in-Chief, and Wiley-VCH Verlag GmbH & Co. KGaA, because portions of the reported results cannot be considered reliable or reproducible. Following an investigation by the RIO of The Pennsylvania State University, it was found that the data in Figure 2a,b and Figure S1a,b (Supporting Information) of the article with DOI: 10.1002/adma.201301243, and Figure S3 (Supporting Information) of the article with DOI: 10.1002/adma.201301370 were falsified. Data regarding the carbon electrode material, A-aMEGO, reported to have a density of 1.15 g cm -3 , in the article with DOI: 10.1002/adma.201301243, were falsified. The RIO of The Pennsylvania State University confirms that the investigation found that the mentioned data were falsified by the first author. No findings of research misconduct were made against the co-authors of these publications. [1] M. Ghaffari, Y. Zhou, H. Xu, M. Lin, T. Y. Kim, R. S. Ruoff, Q. M. Zhang, Adv. Mater. 25: 2013, 4879. doi:10.1002/adma.201301243 [2] M. Ghaffari, W. Kinsman, Y. Zhou, S. Murali, Q. Burlingame, M. Lin, R. S. Ruoff, Q. M. Zhang, Adv. Mater. 25: 2013, 6277. doi:10.1002/adma.201301370. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Wetland methane modelling over the Scandinavian Arctic: Performance of current land-surface models

NASA Astrophysics Data System (ADS)

Hayman, Garry; Quiquet, Aurélien; Gedney, Nicola; Clark, Douglas; Friend, Andrew; George, Charles; Prigent, Catherine

2014-05-01

Wetlands are generally accepted as being the largest, but least well quantified, single natural source of CH4, with global emission estimates ranging from 100-231 Tg yr-1 [1] and for which the Boreal and Arctic regions make a significant contribution [2, 3]. The recent review by Melton et al. [4] has provided a summary of the current state of knowledge on the modelling of wetlands and the outcome of the WETCHIMP model intercomparison exercise. Melton et al. found a large variation in the wetland areas and associated methane emissions from the participating models and varying responses to climate change. In this paper, we report results from offline runs of two land surface models over Scandinavia (JULES, the Joint UK Land Environment Simulator [5, 6] and HYBRID8 [7]), using the same driving meteorological dataset (CRU-NCEP) for the period from January 1980 to December 2010. Although the two land surface models are very different, both models have used a TOPMODEL approach to derive the wetland area and have similar parameterisations of the methane wetland emissions. We find that both models give broadly similar results. They underestimate the wetland areas over Northern Scandinavia, compared to remote sensing and map-based datasets of wetlands [8]. This leads to lower predicted methane emissions compared to those observed on the ground and from aircraft [9]. We will present these findings and identify possible reasons for the underprediction. We will show the sensitivity to using the observed wetland areas to improve the methane emission estimates. References [1] Denman, K., et al.,: Couplings Between Changes in the Climate System and Biogeochemistry, In Climate Change 2007: The Physical Science Basis, Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge University Press, United Kingdom, 2007; [2] Smith, L. C., et al.: Siberian peatlands a net carbon sink and global methane source since the early Holocene, Science, 303, 353-356, doi:10.1126/science.1090553, 2004; [3] Zhuang, Q., et al.: CO2 and CH4 exchanges between land ecosystems and the atmosphere in northern high latitudes over the 21st century, Geophysical Research Letters, 33, doi:10.1029/2006gl026972, 2006; [4] Melton, J.R., et al.: Present state of global wetland extent and wetland methane modelling: conclusions from a model inter-comparison project (WETCHIMP), Biogeosciences, 10, 753-788, doi:10.5194/bg-10-753-2013, 2013; [5] Best, M. J., et al.: The Joint UK Land Environment Simulator (JULES), model description - Part 1: Energy and water fluxes, Geoscientific Model Development, 4, 677-699, doi:10.5194/gmd-4-677-2011, 2011; [6] Clark, D.B., et al.: The Joint UK Land Environment Simulator (JULES), Model description - Part 2: Carbon fluxes and vegetation. Geoscientific Model Development, 4, 701-722, doi:10.5194/gmd-4-701-2011, 2011; [7] Friend, A.D., and N.Y. Kiang: Land surface model development for the GISS GCM: Effects of improved canopy physiology on simulated climate. J. Climate, 18, 2883-2902, doi:10.1175/JCLI3425.1, 2005; [8] Prigent, C., et al.: Changes in land surface water dynamics since the 1990s and relation to population pressure, Geophys. Res. Lett., 39, L08403, doi:10.1029/2012GL051276, 2012; [9] O'Shea, S., et al.: Methane and carbon dioxide fluxes from the European Arctic wetlands during the MAMM project, paper in preparation.

STS-87 crew greet VIPs after successful landing at KSC

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Commander Kevin Kregel, center, shakes hands with the deputy director general of the National Space Agency of Ukraine (NSAU), Eduard Kuznetsov, at far right. Next to Kuznetsov is the Honorable Yuri Shcherbak, Ukraine's ambassador to the United States, standing with the president of the National Space Development Agency (NASDA) of Japan, Isao Uchida, and NASA Administrator Daniel Goldin (center). Approaching the VIPs from the left of the photo are Mission Specialists Kalpana Chawla, Ph.D., and Takao Doi, Ph.D., of NASDA. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16- hour and 34-minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Pilot Steven Lindsey; Mission Specialist Winston Scott; and Payload Specialist Leonid Kadenyuk of NSAU. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

KSC-97PC1744

NASA Image and Video Library

1997-12-05

STS-87 Commander Kevin Kregel, center, shakes hands with the deputy director general of the National Space Agency of Ukraine (NSAU), Eduard Kuznetsov, at far right. Next to Kuznetsov is the Honorable Yuri Shcherbak, Ukraine's ambassador to the United States, standing with the president of the National Space Development Agency (NASDA) of Japan, Isao Uchida, and NASA Administrator Daniel Goldin (center). Approaching the VIPs from the left of the photo are Mission Specialists Kalpana Chawla, Ph.D., and Takao Doi, Ph.D., of NASDA. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16-hour and 34-minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Pilot Steven Lindsey; Mission Specialist Winston Scott; and Payload Specialist Leonid Kadenyuk of NSAU. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program

A Drought Cyberinfrastructure System for Improving Water Resource Management and Policy Making

NASA Astrophysics Data System (ADS)

AghaKouchak, Amir

2015-04-01

Development of reliable monitoring and prediction indices and tools are fundamental to drought preparedness, management, and response decision making. This presentation provides an overview of the Global Integrated Drought Monitoring and Prediction System (GIDMaPS) which offers near real-time drought information using both remote sensing observations and model simulations. Designed as a cyberinfrastructure system, GIDMaPS provides drought information based on a wide range of model simulations and satellite observations from different space agencies. Numerous indices have been developed for drought monitoring based on various indicator variables (e.g., precipitation, soil moisture, water storage). Defining droughts based on a single variable (e.g., precipitation, soil moisture or runoff) may not be sufficient for reliable risk assessment and decision making. GIDMaPS provides drought information based on multiple indices including Standardized Precipitation Index (SPI), Standardized Soil Moisture Index (SSI) and the Multivariate Standardized Drought Index (MSDI) which combines SPI and SSI probabilistically. In other words, MSDI incorporates the meteorological and agricultural drought conditions for overall characterization of droughts, and better management and distribution of water resources among and across different users. The seasonal prediction component of GIDMaPS is based on a persistence model which requires historical data and near-past observations. The seasonal drought prediction component is designed to provide drought information for water resource management, and short-term decision making. In this presentation, both monitoring and prediction components of GIDMaPS will be discussed, and the results from several major droughts including the 2013 Namibia, 2012-2013 United States, 2011-2012 Horn of Africa, and 2010 Amazon Droughts will be presented. The presentation will highlight how this drought cyberinfrastructure system can be used to improve water resource management in California. Furthermore, the presentation provides an overview of the information farmers need for better decision making and how GIDMaPS can be used to improve decision making and reducing drought impacts. Further Reading Hao Z., AghaKouchak A., Nakhjiri N., Farahmand A., 2014, Global Integrated Drought Monitoring and Prediction System, Scientific Data, 1:140001, 1-10, doi: 10.1038/sdata.2014.1. Momtaz F., Nakhjiri N., AghaKouchak A., 2014, Toward a Drought Cyberinfrastructure System, Eos, Transactions American Geophysical Union, 95(22), 182-183, doi:10.1002/2014EO220002. AghaKouchak A., 2014, A Baseline Probabilistic Drought Forecasting Framework Using Standardized Soil Moisture Index: Application to the 2012 United States Drought, Hydrology and Earth System Sciences, 18, 2485-2492, doi: 10.5194/hess-18-2485-2014.

U.S. Department of the Interior South Central Climate Science Center strategic science plan, 2013--18

USGS Publications Warehouse

Winton, Kim T.; Dalton, Melinda S.; Shipp, Allison A.

2013-01-01

The Department of the Interior (DOI) recognizes and embraces the unprecedented challenges of maintaining our Nation’s rich natural and cultural resources in the 21st century. The magnitude of these challenges demands that the conservation community work together to develop integrated adaptation and mitigation strategies that collectively address the impacts of climate change and other landscape-scale stressors. On September 14, 2009, DOI Secretary Ken Salazar signed Secretarial Order 3289 (amended February 22, 2010) entitled, “Addressing the Impacts of Climate Change on America’s Water, Land, and Other Natural and Cultural Resources.” The Order establishes the foundation for two partner-based conservation science entities to address these unprecedented challenges: Climate Science Centers (CSCs and Landscape Conservation Cooperatives (LCCs). CSCs and LCCs are the Department-wide approach for applying scientific tools to increase understanding of climate change and to coordinate an effective response to its impacts on tribes and the land, water, ocean, fish and wildlife, and cultural-heritage resources that DOI manages. Eight CSCs have been established and are managed through the U.S. Geological Survey (USGS) National Climate Change and Wildlife Science Center (NCCWSC); each CSC works in close collaboration with their neighboring CSCs, as well as those across the Nation, to ensure the best and most efficient science is produced. The South Central CSC was established in 2012 through a cooperative agreement with the University of Oklahoma, Texas Tech University, Louisiana State University, the Chickasaw Nation, the Choctaw Nation of Oklahoma, Oklahoma State University, and NOAA’s Geophysical Fluid Dynamics Lab; hereafter termed the ”Consortium” of the South Central CSC. The Consortium has a broad expertise in the physical, biological, natural, and social sciences to address impacts of climate change on land, water, fish and wildlife, ocean, coastal, and cultural resources. The South Central CSC will provide scientific information, tools, and techniques that managers and other parties interested in land, water, wildlife, and cultural resources can use to anticipate, monitor, and adapt to climate change, actively engaging LCCs and other partners in translating science into management decisions. This document is the first Strategic Science Plan for the South Central CSC (2013-18). Using the January 2011 DOI guidance as a model, this document (1) describes the role and interactions of the South Central CSC among partners and stakeholders including Federal, State, and non-governmental organizations throughout the region; (2) describes a concept of what the center will provide to its partners; (3) defines a context for climate impacts in the south central United States; and (4) establishes the science priorities the center will address through research. Science priorities are currently organized as immediate or future research needs; however, this document is intended to be reevaluated and modified as partner needs change and as scientific work progresses.

U.S. Geological Survey (USGS) Western Region: Alaska Coastal and Ocean Science

USGS Publications Warehouse

Holland-Bartels, Leslie

2009-01-01

The U.S. Geological Survey (USGS), a bureau of the Department of the Interior (DOI), is the Nation's largest water, earth, and biological science and mapping agency. The bureau's science strategy 'Facing Tomorrow's Challenges - U.S. Geological Survey Science in the Decade 2007-2017' describes the USGS vision for its science in six integrated areas of societal concern: Understanding Ecosystems and Predicting Ecosystem Change; Climate Variability and Change; Energy and Minerals; Hazards, Risk, and Resilience; Environment and Wildlife in Human Health; and Water Census of the United States. USGS has three Regions that encompass nine geographic Areas. This fact sheet describes examples of USGS science conducted in coastal, nearshore terrestrial, and ocean environments in the Alaska Area.

STS-87 Crew walkout of O&C building

NASA Technical Reports Server (NTRS)

1997-01-01

The crew of Mission STS-87 depart from the Operations and Checkout Building en route to Launch Pad 39B, where the Space Shuttle Columbia awaits liftoff on the fourth flight of the United States Microgravity Payload and the Spartan-201deployable satellite. Leading the way are, from left to right, front to back: Mission Specialist Kalpana Chawla, Ph.D.; Commander Kevin Kregel; Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Mission Specialist Winston Scott; Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine; and Pilot Steven Lindsey. The Space Shuttle Columbia and its crew of six members are scheduled to lift off during a two-and-a-half hour launch window, which opens at 2:46 p.m.

The Association between Dust Storms and Daily Non-Accidental Mortality in the United States, 1993–2005

PubMed Central

Crooks, James Lewis; Cascio, Wayne E.; Percy, Madelyn S.; Reyes, Jeanette; Neas, Lucas M.; Hilborn, Elizabeth D.

2016-01-01

Background: The impact of dust storms on human health has been studied in the context of Asian, Saharan, Arabian, and Australian storms, but there has been no recent population-level epidemiological research on the dust storms in North America. The relevance of dust storms to public health is likely to increase as extreme weather events are predicted to become more frequent with anticipated changes in climate through the 21st century. Objectives: We examined the association between dust storms and county-level non-accidental mortality in the United States from 1993 through 2005. Methods: Dust storm incidence data, including date and approximate location, are taken from the U.S. National Weather Service storm database. County-level mortality data for the years 1993–2005 were acquired from the National Center for Health Statistics. Distributed lag conditional logistic regression models under a time-stratified case-crossover design were used to study the relationship between dust storms and daily mortality counts over the whole United States and in Arizona and California specifically. End points included total non-accidental mortality and three mortality subgroups (cardiovascular, respiratory, and other non-accidental). Results: We estimated that for the United States as a whole, total non-accidental mortality increased by 7.4% (95% CI: 1.6, 13.5; p = 0.011) and 6.7% (95% CI: 1.1, 12.6; p = 0.018) at 2- and 3-day lags, respectively, and by an average of 2.7% (95% CI: 0.4, 5.1; p = 0.023) over lags 0–5 compared with referent days. Significant associations with non-accidental mortality were estimated for California (lag 2 and 0–5 day) and Arizona (lag 3), for cardiovascular mortality in the United States (lag 2) and Arizona (lag 3), and for other non-accidental mortality in California (lags 1–3 and 0–5). Conclusions: Dust storms are associated with increases in lagged non-accidental and cardiovascular mortality. Citation: Crooks JL, Cascio WE, Percy MS, Reyes J, Neas LM, Hilborn ED. 2016. The association between dust storms and daily non-accidental mortality in the United States, 1993–2005. Environ Health Perspect 124:1735–1743; http://dx.doi.org/10.1289/EHP216 PMID:27128449

Space Particle Hazard Measurement and Modeling

DTIC Science & Technology

2016-09-01

understand the interactions of the physical processes driving, then specify and ultimately predict the state of the energetic particle populations...Hudson, and B. T. Kress (2013), Direct observation of the CRAND proton radiation belt source, J. Geophys. Res. Space Physics , 118, doi:10.1002...anticritical temperature for spacecraft charging, J. Geophys Res.: Space Physics , 113, 2156-2202, doi: 10.1029/2008JA013161 2010 – Tested basic

An Analysis of the Potential Impact of Climate Change on Dengue Transmission in the Southeastern United States

PubMed Central

Butterworth, Melinda K.; Morin, Cory W.; Comrie, Andrew C.

2016-01-01

Background: Dengue fever, caused by a mosquito-transmitted virus, is an increasing health concern in the Americas. Meteorological variables such as temperature and precipitation can affect disease distribution and abundance through biophysical impacts on the vector and on the virus. Such tightly coupled links may facilitate further spread of dengue fever under a changing climate. In the southeastern United States, the dengue vector is widely established and exists on the current fringe of dengue transmission. Objectives: We assessed projected climate change–driven shifts in dengue transmission risk in this region. Methods: We used a dynamic mosquito population and virus transmission model driven by meteorological data to simulate Aedes aegypti populations and dengue cases in 23 locations in the southeastern United States under current climate conditions and future climate projections. We compared estimates for each location with simulations based on observed data from San Juan, Puerto Rico, where dengue is endemic. Results: Our simulations based on current climate data suggest that dengue transmission at levels similar to those in San Juan is possible at several U.S. locations during the summer months, particularly in southern Florida and Texas. Simulations that include climate change projections suggest that conditions may become suitable for virus transmission in a larger number of locations and for a longer period of time during each year. However, in contrast with San Juan, U.S. locations would not sustain year-round dengue transmission according to our model. Conclusions: Our findings suggest that Dengue virus (DENV) transmission is limited by low winter temperatures in the mainland United States, which are likely to prevent its permanent establishment. Although future climate conditions may increase the length of the mosquito season in many locations, projected increases in dengue transmission are limited to the southernmost locations. Citation: Butterworth MK, Morin CW, Comrie AC. 2017. An analysis of the potential impact of climate change on dengue transmission in the southeastern United States. Environ Health Perspect 125:579–585; http://dx.doi.org/10.1289/EHP218 PMID:27713106

Ground-water conditions in the Dutch Flats area, Scotts Bluff and Sioux Counties, Nebraska, with a section on chemical quality of the ground water

USGS Publications Warehouse

Babcock, H.M.; Visher, F.N.; Durum, W.H.

1951-01-01

The U.S. Department of the Interior (DOI) studied contamination induced by irrigation drainage in 26 areas of the Western United States during 1986-95. Comprehensive compilation, synthesis, and evaluation of the data resulting from these studies were initiated by DOI in 1992. Soils and ground water in irrigated areas of the West can contain high concentrations of selenium because of (1) residual selenium from the soil's parent rock beneath irrigated land; (2) selenium derived from rocks in mountains upland from irrigated land by erosion and transport along local drainages, and (3) selenium brought into the area in surface water imported for irrigation. Application of irrigation water to seleniferous soils can dissolve and mobilize selenium and create hydraulic gradients that cause the discharge of seleniferous ground water into irrigation drains. Given a source of selenium, the magnitude of selenium contamination in drainage-affected aquatic ecosystems is strongly related to the aridity of the area and the presence of terminal lakes and ponds. Marine sedimentary rocks and deposits of Late Cretaceous or Tertiary age are generally seleniferous in the Western United States. Depending on their origin and history, some Tertiary continental sedimentary deposits also are seleniferous. Irrigation of areas associated with these rocks and deposits can result in concentrations of selenium in water that exceed criteria for the protection of freshwater aquatic life. Geologic and climatic data for the Western United States were evaluated and incorporated into a geographic information system (GIS) to produce a map identifying areas susceptible to irrigation-induced selenium contamination. Land is considered susceptible where a geologic source of selenium is in or near the area and where the evaporation rate is more than 2.5 times the precipitation rate. In the Western United States, about 160,000 square miles of land, which includes about 4,100 square miles (2.6 million acres) of land irrigated for agriculture, has been identified as being susceptible. Biological data were used to evaluate the reliability of the map. In 12 of DOI's 26 study areas, concentrations of selenium measured in bird eggs were elevated sufficiently to significantly reduce hatchability of the eggs. The GIS map identifies 9 of those 12 areas. Deformed bird embryos having classic symptoms of selenium toxicosis were found in four of the study areas, and the map identifies all four as susceptible to irrigation-induced selenium contamination. The report describes the geography, geology, and ground-water resources of the Dutch Flats area in Scotts Bluff and Sioux Counties, Nebr. The area comprises about 60 square miles and consists predominantly of relatively flat-lying terraces. Farming is the principal occupation in the area. The farm lands are irrigated largely from surface water; ground water is used only as a supplementary supply during drought periods. The climate in the area is semiarid, and the mean annual precipitation is about 16 inches. The rocks exposed in the Dutch Flats area are of Tertiary sad Quaternary age. A map showing the areas of outcrop of the rock formations is included in the report. Sufficient unconfined ground water for irrigation supplies is contained in the deposits of the .third terrace, and wells that yield 1,000 to 2,000 gallons a minute probably could be developed. The depth to water in the area ranges from a few feet to about 80 feet sad averages about 30 feet. The depth to water varies throughout the year; it is least in the late summer when the recharge from irrigation is greatest, sad it is greatest in the early spring before irrigation is begun. A map showing the depth to water in September 1949 is included in the report. The ground-water reservoir is recharged by seepage from irrigation canals and laterals, by seepage from irrigation water applied to the farms, and, to a much lesser extent, by precipitation. In the area b

A continuum model of transcriptional bursting

PubMed Central

Corrigan, Adam M; Tunnacliffe, Edward; Cannon, Danielle; Chubb, Jonathan R

2016-01-01

Transcription occurs in stochastic bursts. Early models based upon RNA hybridisation studies suggest bursting dynamics arise from alternating inactive and permissive states. Here we investigate bursting mechanism in live cells by quantitative imaging of actin gene transcription, combined with molecular genetics, stochastic simulation and probabilistic modelling. In contrast to early models, our data indicate a continuum of transcriptional states, with a slowly fluctuating initiation rate converting the gene between different levels of activity, interspersed with extended periods of inactivity. We place an upper limit of 40 s on the lifetime of fluctuations in elongation rate, with initiation rate variations persisting an order of magnitude longer. TATA mutations reduce the accessibility of high activity states, leaving the lifetime of on- and off-states unchanged. A continuum or spectrum of gene states potentially enables a wide dynamic range for cell responses to stimuli. DOI: http://dx.doi.org/10.7554/eLife.13051.001 PMID:26896676

Scott and Doi conduct tool evaluations during second EVA of STS-87

NASA Image and Video Library

1997-12-03

STS087-341-036 (3 Dec. 1997) --- Backdropped against a dark Earth and a light blue horizon, astronaut Takao Doi (right), international mission specialist representing Japan's National Space Development Agency (NASDA), works with a crane while astronaut Winston E. Scott looks on. This second extravehicular activity (EVA) of the mission continued the evaluation of techniques and hardware to be used in constructing the International Space Station (ISS). Near Scott can be seen the representation of a small Orbital Replacement Unit (ORU) in the grasp of the 156-pound crane operated by Doi. A similar crane could be used to transport various sized ORU’s from translation carts on the exterior of the ISS to various worksites on the truss structure. This view was captured, on 35mm film, by a crew mate in the shirt sleeve environment of the Space Shuttle Columbia's cabin. The SPARTAN-201 satellite is in its stowed position at frame center.

Magnetic resonance imaging features of dogs with incomplete recovery after acute, severe spinal cord injury

PubMed Central

Lewis, Melissa J.; Cohen, Eli B.; Olby, Natasha J.

2017-01-01

Study Design Retrospective case series Objectives Describe the magnetic resonance imaging (MRI) features of dogs chronically impaired after severe spinal cord injury (SCI) and investigate associations between imaging variables and residual motor function. Setting United States of America Methods Thoracolumbar MRI from dogs with incomplete recovery months to years after clinically complete (paralysis with loss of pain perception) thoracolumbar SCI were reviewed. Lesion features were described and quantified. Gait was quantified using an ordinal, open field scale (OFS). Associations between imaging features and gait scores, duration of injury (DOI) or SCI treatment were determined. Results 35 dogs were included. Median OFS was 2 (0–6), median DOI was 13 months (3–83) and intervertebral disc herniation was the most common diagnosis (n=27). Myelomalacia was the most common qualitative feature followed by cystic change; syringomyelia and fibrosis were uncommon. Lesion length corrected to L2 length (LL:L2) was variable (median LL:L2=3.5 (1.34–11.54)). Twenty-nine dogs had 100% maximum cross-sectional spinal cord compromise (MSCC) at the lesion epicenter and the length of 100% compromised area varied widely (median length 100% MSCC:L2=1.29 (0.39–7.64). Length 100% MSCC:L2 was associated with OFS (p=0.012). OFS was not associated with any qualitative features. DOI or treatment type were not associated with imaging features or lesion quantification. Conclusions Lesion characteristics on MRI in dogs with incomplete recovery after severe SCI were established. Length of 100% MSCC was associated with hind limb motor function. Findings demonstrate a spectrum of injury severity on MRI amongst severely affected dogs which is related to functional status. PMID:29057987

An inhibitory gate for state transition in cortex

PubMed Central

Zucca, Stefano; D’Urso, Giulia; Pasquale, Valentina; Vecchia, Dania; Pica, Giuseppe; Bovetti, Serena; Moretti, Claudio; Varani, Stefano; Molano-Mazón, Manuel; Chiappalone, Michela; Panzeri, Stefano; Fellin, Tommaso

2017-01-01

Large scale transitions between active (up) and silent (down) states during quiet wakefulness or NREM sleep regulate fundamental cortical functions and are known to involve both excitatory and inhibitory cells. However, if and how inhibition regulates these activity transitions is unclear. Using fluorescence-targeted electrophysiological recording and cell-specific optogenetic manipulation in both anesthetized and non-anesthetized mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin positive cells, tightly control both up-to-down and down-to-up state transitions. Inhibitory regulation of state transition was observed under both natural and optogenetically-evoked conditions. Moreover, perturbative optogenetic experiments revealed that the inhibitory control of state transition was interneuron-type specific. Finally, local manipulation of small ensembles of interneurons affected cortical populations millimetres away from the modulated region. Together, these results demonstrate that inhibition potently gates transitions between cortical activity states, and reveal the cellular mechanisms by which local inhibitory microcircuits regulate state transitions at the mesoscale. DOI: http://dx.doi.org/10.7554/eLife.26177.001 PMID:28509666

Ciguatera Fish Poisoning and Climate Change: Analysis of National Poison Center Data in the United States, 2001–2011

PubMed Central

Strickland, Matthew J.; Hess, Jeremy J.

2014-01-01

Background: Warm sea surface temperatures (SSTs) are positively related to incidence of ciguatera fish poisoning (CFP). Increased severe storm frequency may create more habitat for ciguatoxic organisms. Although climate change could expand the endemic range of CFP, the relationship between CFP incidence and specific environmental conditions is unknown. Objectives: We estimated associations between monthly CFP incidence in the contiguous United States and SST and storm frequency in the Caribbean basin. Methods: We obtained information on 1,102 CFP-related calls to U.S. poison control centers during 2001–2011 from the National Poison Data System. We performed a time-series analysis using Poisson regression to relate monthly CFP call incidence to SST and tropical storms. We investigated associations across a range of plausible lag structures. Results: Results showed associations between monthly CFP calls and both warmer SSTs and increased tropical storm frequency. The SST variable with the strongest association linked current monthly CFP calls to the peak August SST of the previous year. The lag period with the strongest association for storms was 18 months. If climate change increases SST in the Caribbean 2.5–3.5°C over the coming century as projected, this model implies that CFP incidence in the United States is likely to increase 200–400%. Conclusions: Using CFP calls as a marker of CFP incidence, these results clarify associations between climate variability and CFP incidence and suggest that, all other things equal, climate change could increase the burden of CFP. These findings have implications for disease prediction, surveillance, and public health preparedness for climate change. Citation: Gingold DB, Strickland MJ, Hess JJ. 2014. Ciguatera fish poisoning and climate change: analysis of National Poison Center data in the United States, 2001–2011. Environ Health Perspect 122:580–586; http://dx.doi.org/10.1289/ehp.1307196 PMID:24618280

Biomarker Levels of Toxic Metals among Asian Populations in the United States: NHANES 2011–2012

PubMed Central

Awata, Hiroshi; Linder, Stephen; Mitchell, Laura E.; Delclos, George L.

2016-01-01

Introduction: The Centers for Disease Control and Prevention (CDC) recently found that Asians have considerably higher biomarker levels of cadmium, lead, mercury, and arsenic than whites, blacks, Mexican Americans, and other Hispanics in the United States. Objective: Our goal was to further evaluate the higher metal biomarker levels among Asians. Methods: Biomarker data (blood cadmium, blood lead, blood mercury, urinary total arsenic, and urinary dimethylarsinic acic) from individuals ≥ 6 years of age were obtained from the 2011–2012 National Health and Nutrition Examination Survey (NHANES). We compared geometric mean levels of these five metal biomarkers in Asians with those of four other NHANES race/ethnic groups (white, black, Mexican American, and other Hispanic), and across three Asian subgroups (Chinese, Asian Indian, and other Asian). We also evaluated associations between biomarker levels and sociodemographic, physical, dietary, and behavioral covariates across the Asian subgroups. Results: Asians had significantly higher levels of all five metal biomarkers than other race/ethnic groups (p < 0.05), regardless of sociodemographic, physical, dietary, behavioral, or geographic characteristics. We also found variations in biomarker levels across the Asian subgroups. In general, Asian Indians had lower levels than the other two Asian subgroups, except for blood lead. The following characteristics were found to be significant predictors of several biomarker levels: sex, age, education, birthplace, smoking, and fish consumption. Conclusions: Overall, the Asian group had the highest geometric mean biomarker levels for all of the five metal variables. Furthermore, we provided evidence that significant variations in the biomarker levels are present across the Asian subgroups in the United States. Citation: Awata H, Linder S, Mitchell LE, Delclos GL. 2017. Biomarker levels of toxic metals among Asian populations in the United States: NHANES 2011–2012. Environ Health Perspect 125:306–313; http://dx.doi.org/10.1289/EHP27 PMID:27517362

Subsurface structure of Planum Boreum from Mars Reconnaissance Orbiter Shallow Radar soundings

NASA Astrophysics Data System (ADS)

Putzig, Nathaniel E.; Phillips, Roger J.; Campbell, Bruce A.; Holt, John W.; Plaut, Jeffrey J.; Carter, Lynn M.; Egan, Anthony F.; Bernardini, Fabrizio; Safaeinili, Ali; Seu, Roberto

2009-12-01

We map the subsurface structure of Planum Boreum using sounding data from the Shallow Radar (SHARAD) instrument onboard the Mars Reconnaissance Orbiter. Radar coverage throughout the 1,000,000-km 2 area reveals widespread reflections from basal and internal interfaces of the north polar layered deposits (NPLD). A dome-shaped zone of diffuse reflectivity up to 12 μs (˜1-km thick) underlies two-thirds of the NPLD, predominantly in the main lobe but also extending into the Gemina Lingula lobe across Chasma Boreale. We equate this zone with a basal unit identified in image data as Amazonian sand-rich layered deposits [Byrne, S., Murray, B.C., 2002. J. Geophys. Res. 107, 5044, 12 pp. doi:10.1029/2001JE001615; Fishbaugh, K.E., Head, J.W., 2005. Icarus 174, 444-474; Tanaka, K.L., Rodriguez, J.A.P., Skinner, J.A., Bourke, M.C., Fortezzo, C.M., Herkenhoff, K.E., Kolb, E.J., Okubo, C.H., 2008. Icarus 196, 318-358]. Elsewhere, the NPLD base is remarkably flat-lying and co-planar with the exposed surface of the surrounding Vastitas Borealis materials. Within the NPLD, we delineate and map four units based on the radar-layer packets of Phillips et al. [Phillips, R.J., and 26 colleagues, 2008. Science 320, 1182-1185] that extend throughout the deposits and a fifth unit confined to eastern Gemina Lingula. We estimate the volume of each internal unit and of the entire NPLD stack (821,000 km 3), exclusive of the basal unit. Correlation of these units to models of insolation cycles and polar deposition [Laskar, J., Levrard, B., Mustard, J.F., 2002. Nature 419, 375-377; Levrard, B., Forget, F., Montmessin, F., Laskar, J., 2007. J. Geophys. Res. 112, E06012, 18 pp. doi:10.1029/2006JE002772] is consistent with the 4.2-Ma age of the oldest preserved NPLD obtained by Levrard et al. [Levrard, B., Forget, F., Montmessin, F., Laskar, J., 2007. J. Geophys. Res. 112, E06012, 18 pp. doi:10.1029/2006JE002772]. We suggest a dominant layering mechanism of dust-content variation during accumulation rather than one of lag production during periods of sublimation.

Intensity Modulated Radiation Treatment of Prostate Cancer Guided by High Field MR Spectroscopic Imaging

DTIC Science & Technology

2005-05-01

constructed with incorporation of the nonuniform dose prescription. The functional unit density distribution in a sensitive structure is also considered...of the corresponding organ, and -b(i) is the target, we define the effective dose at a voxel as the physical functional unit density. The value of n...cr, tended to include the nonuniform functional unit density dis- D,(i) the calculated dose in voxel i, DO(i) the prescription tribution using Eq. (8

Reply to Comment by W. R. Peltier, D. F. Argus, and R. Drummond on "An Assessment of the ICE6G_C (VM5a) Glacial Isostatic Adjustment Model"

NASA Astrophysics Data System (ADS)

Purcell, A.; Tregoning, P.; Dehecq, A.

2018-02-01

The empirical approximation of Purcell et al. (2011, https://doi.org/10.1029/2011GL048624) has been validated by Peltier et al. (2018, https://doi.org/10.1002/2016JB013844). In their Comment they introduced new results derived from the same ice/rheology models of ICE6G_C (VM5a) but using a different model for Antarctic bathymetry. This has greatly reduced the differences in predicted Antarctic uplift rates relative to those of Purcell et al. (2016, https://doi.org/10.1002/2015JB012742). In fact, with a ˜50% reduction in uplift rate in the Weddell Sea, the results of Peltier et al. (2018, https://doi.org/10.1002/2016JB013844) now agree more closely with the predictions of Purcell et al. (2016, https://doi.org/10.1002/2015JB012742) than with the original ICE6G_C values. Peltier et al. (2018, https://doi.org/10.1002/2016JB013844) state that the high power in their high-frequency spherical harmonic coefficients remains in their new calculations. They also claim that Purcell et al. (2016, https://doi.org/10.1002/2015JB012742) used an inaccurate loading history in deriving their velocity field. In fact, the ice load history was unchanged; to remove any ambiguity, the ice and water load histories used in the CALSEA calculations are provided in the supporting information.

A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy

PubMed Central

Munder, Matthias Christoph; Midtvedt, Daniel; Franzmann, Titus; Nüske, Elisabeth; Otto, Oliver; Herbig, Maik; Ulbricht, Elke; Müller, Paul; Taubenberger, Anna; Maharana, Shovamayee; Malinovska, Liliana; Richter, Doris; Guck, Jochen; Zaburdaev, Vasily; Alberti, Simon

2016-01-01

Cells can enter into a dormant state when faced with unfavorable conditions. However, how cells enter into and recover from this state is still poorly understood. Here, we study dormancy in different eukaryotic organisms and find it to be associated with a significant decrease in the mobility of organelles and foreign tracer particles. We show that this reduced mobility is caused by an influx of protons and a marked acidification of the cytoplasm, which leads to widespread macromolecular assembly of proteins and triggers a transition of the cytoplasm to a solid-like state with increased mechanical stability. We further demonstrate that this transition is required for cellular survival under conditions of starvation. Our findings have broad implications for understanding alternative physiological states, such as quiescence and dormancy, and create a new view of the cytoplasm as an adaptable fluid that can reversibly transition into a protective solid-like state. DOI: http://dx.doi.org/10.7554/eLife.09347.001 PMID:27003292

Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off

PubMed Central

Corrales-Carvajal, Verónica María; Faisal, Aldo A; Ribeiro, Carlos

2016-01-01

Internal states can profoundly alter the behavior of animals. A quantitative understanding of the behavioral changes upon metabolic challenges is key to a mechanistic dissection of how animals maintain nutritional homeostasis. We used an automated video tracking setup to characterize how amino acid and reproductive states interact to shape exploitation and exploration decisions taken by adult Drosophila melanogaster. We find that these two states have specific effects on the decisions to stop at and leave proteinaceous food patches. Furthermore, the internal nutrient state defines the exploration-exploitation trade-off: nutrient-deprived flies focus on specific patches while satiated flies explore more globally. Finally, we show that olfaction mediates the efficient recognition of yeast as an appropriate protein source in mated females and that octopamine is specifically required to mediate homeostatic postmating responses without affecting internal nutrient sensing. Internal states therefore modulate specific aspects of exploitation and exploration to change nutrient selection. DOI: http://dx.doi.org/10.7554/eLife.19920.001 PMID:27770569

How Far Has the International Neurourology Journal Progressed Since Its Transformation Into an English Language Journal?

PubMed Central

2014-01-01

Purpose The publisher of the International Neurourology Journal changed the text to English in 2010 to promote the journal as an international publication. Four years later, what has happened to this journal? This paper will use citation indicators to describe the degree of internationalization. Methods Citation indicators such as impact factors, total citations from Web of Science, Science Journal Rankings (SJR), cites per documents (2 years), and Hirsch indexes (h-indexes) from Web of Science, digital object identifier (DOI)/CrossRef, ScimagoJR, or Scopus were calculated. In addition, the native countries of the authors and researchers citing the journal in Web of Science were analyzed. Results Impact factors in 2012 and 2013 were 0.645 and 0.857, respectively. Total citations in 2011, 2012, and 2013 from Web of Science were 15, 51, and 99, respectively, and the SJRs in 2011 and 2012 were 0.220 and 0.390, respectively. The h-indexes from DOI/CrossRef, Scopus, and Web of Science were 7, 8, and 6, respectively. Out of 153 unsolicited published papers, 27 (17.6%) were from outside of Korea. The researchers citing the journal in Web of Science and Scopus were primarily from the United States, Korea, China, the United Kingdom, and France. Funding agencies supported 39 of 101 original articles (38.6%). Conclusions After changing the text to the English language, the citation indicators show that the International Neurourology Journal has been elevated to an international journal. Although the nationality of authors varies from year to year, the increase in the number of manuscripts from international authors is obvious. PMID:24729921

Active faults newly identified in Pacific Northwest

NASA Astrophysics Data System (ADS)

Balcerak, Ernie

2012-05-01

The Bellingham Basin, which lies north of Seattle and south of Vancouver around the border between the United States and Canada in the northern part of the Cascadia subduction zone, is important for understanding the regional tectonic setting and current high rates of crustal deformation in the Pacific Northwest. Using a variety of new data, Kelsey et al. identified several active faults in the Bellingham Basin that had not been previously known. These faults lie more than 60 kilometers farther north of the previously recognized northern limit of active faulting in the area. The authors note that the newly recognized faults could produce earthquakes with magnitudes between 6 and 6.5 and thus should be considered in hazard assessments for the region. (Journal of Geophysical Reserch-Solid Earth, doi:10.1029/2011JB008816, 2012)

STS-87 Crew walkout of O&C building

NASA Technical Reports Server (NTRS)

1997-01-01

The crew of Mission STS-87 depart from the Operations and Checkout Building en route to Launch Pad 39B, where the Space Shuttle Columbia awaits liftoff on the fourth flight of the United States Microgravity Payload and the Spartan-201deployable satellite. They are, from left to right, front to back: Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Mission Specialist Winston Scott (near van); Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine; and Pilot Steven Lindsey (near van). Missing from this photo are Commander Kevin Kregel and Mission Specialist Kalpana Chawla, Ph.D. The Space Shuttle Columbia and its crew of six members are scheduled to lift off during a two-and-a-half hour launch window, which opens at 2:46 p.m.

Volumetric analysis of day of injury computed tomography is associated with rehabilitation outcomes after traumatic brain injury.

PubMed

Majercik, Sarah; Bledsoe, Joseph; Ryser, David; Hopkins, Ramona O; Fair, Joseph E; Brock Frost, R; MacDonald, Joel; Barrett, Ryan; Horn, Susan; Pisani, David; Bigler, Erin D; Gardner, Scott; Stevens, Mark; Larson, Michael J

2017-01-01

Day-of-injury (DOI) brain lesion volumes in traumatic brain injury (TBI) patients are rarely used to predict long-term outcomes in the acute setting. The purpose of this study was to investigate the relationship between acute brain injury lesion volume and rehabilitation outcomes in patients with TBI at a level one trauma center. Patients with TBI who were admitted to our rehabilitation unit after the acute care trauma service from February 2009-July 2011 were eligible for the study. Demographic data and outcome variables including cognitive and motor Functional Independence Measure (FIM) scores, length of stay (LOS) in the rehabilitation unit, and ability to return to home were obtained. The DOI quantitative injury lesion volumes and degree of midline shift were obtained from DOI brain computed tomography scans. A multiple stepwise regression model including 13 independent variables was created. This model was used to predict postrehabilitation outcomes, including FIM scores and ability to return to home. A p value less than 0.05 was considered significant. Ninety-six patients were enrolled in the study. Mean age was 43 ± 21 years, admission Glasgow Coma Score was 8.4 ± 4.8, Injury Severity Score was 24.7 ± 9.9, and head Abbreviated Injury Scale score was 3.73 ± 0.97. Acute hospital LOS was 12.3 ± 8.9 days, and rehabilitation LOS was 15.9 ± 9.3 days. Day-of-injury TBI lesion volumes were inversely associated with cognitive FIM scores at rehabilitation admission (p = 0.004) and discharge (p = 0.004) and inversely associated with ability to be discharged to home after rehabilitation (p = 0.006). In a cohort of patients with moderate to severe TBI requiring a rehabilitation unit stay after the acute care hospital stay, DOI brain injury lesion volumes are associated with worse cognitive FIM scores at the time of rehabilitation admission and discharge. Smaller-injury volumes were associated with eventual discharge to home. Volumetric neuroimaging in the acute injury phase may improve surgeons' ultimate outcome predictions in TBI patients. Prognostic/epidemiologic study, level V.

Volumetric analysis of day of injury computed tomography is associated with rehabilitation outcomes after traumatic brain injury

PubMed Central

Majercik, Sarah; Bledsoe, Joseph; Ryser, David; Hopkins, Ramona O.; Fair, Joseph E.; Frost, R. Brock; MacDonald, Joel; Barrett, Ryan; Horn, Susan; Pisani, David; Bigler, Erin D.; Gardner, Scott; Stevens, Mark; Larson, Michael J.

2016-01-01

Introduction Day-of-injury (DOI) brain lesion volumes in traumatic brain injury (TBI) patients are rarely used to predict long-term outcomes in the acute setting. The purpose of this study was to investigate the relationship between acute brain injury lesion volume and rehabilitation outcomes in patients with TBI at a Level One Trauma Center. Methods Patients with TBI who were admitted to our rehabilitation unit after the acute care trauma service from February 2009-July 2011 were eligible for the study. Demographic data and outcome variables including cognitive and motor FIM scores, length of stay (LOS) in the rehabilitation unit, and ability to return to home were obtained. DOI quantitative injury lesion volumes and degree of midline shift were obtained from day-of-injury (DOI) brain computed tomography (CT) scans. A multiple step-wise regression model including 13 independent variables was created. This model was used to predict post-rehabilitation outcomes, including FIM scores and ability to return to home. P<0.05 was considered significant. Results 96 patients were enrolled in the study. Mean age was 43±21 years, admission Glasgow Coma Score 8.4±4.8, Injury Severity Score 24.7±9.9, and head Abbreviated Injury Scale score 3.73±0.97. Acute hospital length of stay (LOS) was 12.3±8.9 days and rehabilitation LOS was 15.9±9.3 days. Day-of-injury TBI lesion volumes were inversely associated with cognitive FIM scores at rehabilitation admission (p=0.004) and discharge (p=0.004) and inversely associated with ability to be discharged to home after rehabilitation (p=0.006). Conclusion In a cohort of patients with moderate to severe TBI requiring a rehabilitation unit stay after the acute care hospital stay, DOI brain injury lesion volumes are associated with worse cognitive FIM scores at the time of rehabilitation admission and discharge. Smaller injury volumes were associated with eventual discharge to home. Volumetric neuroimaging in the acute injury phase may improve surgeons’ ultimate outcome predictions in TBI patients. Level of Evidence/Study Type Level V, case series, Prognostic/Epidemiological PMID:27805992

Space Shuttle Projects

NASA Image and Video Library

1997-09-01

Five astronauts and a payload specialist take a break from training at the Johnson Space Center (JSC) to pose for the STS-87 crew portrait. Wearing the orange partial pressure launch and entry suits, from the left, are Kalpana Chawla, mission specialist; Steven W. Lindsey, pilot; Kevin R. Kregel, mission commander; and Leonid K. Kadenyuk, Ukrainian payload specialist. Wearing the white Extravehicular Mobility Unit (EMU) space suits are mission specialists Winston E. Scott (left) and Takao Doi (right). Doi represents Japan’s National Space Development Agency (NASDA). The STS-87 mission launched aboard the Space Shuttle Columbia on November 19, 1997. The primary payload for the mission was the U.S. Microgravity Payload-4 (USMP-4).

Changes in Transportation-Related Air Pollution Exposures by Race-Ethnicity and Socioeconomic Status: Outdoor Nitrogen Dioxide in the United States in 2000 and 2010

PubMed Central

Clark, Lara P.; Millet, Dylan B.

2017-01-01

Background: Disparities in exposure to air pollution by race-ethnicity and by socioeconomic status have been documented in the United States, but the impacts of declining transportation-related air pollutant emissions on disparities in exposure have not been studied in detail. Objective: This study was designed to estimate changes over time (2000 to 2010) in disparities in exposure to outdoor concentrations of a transportation-related air pollutant, nitrogen dioxide (NO2), in the United States. Methods: We combined annual average NO2 concentration estimates from a temporal land use regression model with Census demographic data to estimate outdoor exposures by race-ethnicity, socioeconomic characteristics (income, age, education), and by location (region, state, county, urban area) for the contiguous United States in 2000 and 2010. Results: Estimated annual average NO2 concentrations decreased from 2000 to 2010 for all of the race-ethnicity and socioeconomic status groups, including a decrease from 17.6 ppb to 10.7 ppb (−6.9 ppb) in nonwhite [non-(white alone, non-Hispanic)] populations, and 12.6 ppb to 7.8 ppb (−4.7 ppb) in white (white alone, non-Hispanic) populations. In 2000 and 2010, disparities in NO2 concentrations were larger by race-ethnicity than by income. Although the national nonwhite–white mean NO2 concentration disparity decreased from a difference of 5.0 ppb in 2000 to 2.9 ppb in 2010, estimated mean NO2 concentrations remained 37% higher for nonwhites than whites in 2010 (40% higher in 2000), and nonwhites were 2.5 times more likely than whites to live in a block group with an average NO2 concentration above the WHO annual guideline in 2010 (3.0 times more likely in 2000). Conclusions: Findings suggest that absolute NO2 exposure disparities by race-ethnicity decreased from 2000 to 2010, but relative NO2 exposure disparities persisted, with higher NO2 concentrations for nonwhites than whites in 2010. https://doi.org/10.1289/EHP959 PMID:28930515

Changes in Transportation-Related Air Pollution Exposures by Race-Ethnicity and Socioeconomic Status: Outdoor Nitrogen Dioxide in the United States in 2000 and 2010.

PubMed

Clark, Lara P; Millet, Dylan B; Marshall, Julian D

2017-09-14

Disparities in exposure to air pollution by race-ethnicity and by socioeconomic status have been documented in the United States, but the impacts of declining transportation-related air pollutant emissions on disparities in exposure have not been studied in detail. This study was designed to estimate changes over time (2000 to 2010) in disparities in exposure to outdoor concentrations of a transportation-related air pollutant, nitrogen dioxide (NO2), in the United States. We combined annual average NO2 concentration estimates from a temporal land use regression model with Census demographic data to estimate outdoor exposures by race-ethnicity, socioeconomic characteristics (income, age, education), and by location (region, state, county, urban area) for the contiguous United States in 2000 and 2010. Estimated annual average NO2 concentrations decreased from 2000 to 2010 for all of the race-ethnicity and socioeconomic status groups, including a decrease from 17.6 ppb to 10.7 ppb (-6.9 ppb) in nonwhite [non-(white alone, non-Hispanic)] populations, and 12.6 ppb to 7.8 ppb (-4.7 ppb) in white (white alone, non-Hispanic) populations. In 2000 and 2010, disparities in NO2 concentrations were larger by race-ethnicity than by income. Although the national nonwhite-white mean NO2 concentration disparity decreased from a difference of 5.0 ppb in 2000 to 2.9 ppb in 2010, estimated mean NO2 concentrations remained 37% higher for nonwhites than whites in 2010 (40% higher in 2000), and nonwhites were 2.5 times more likely than whites to live in a block group with an average NO2 concentration above the WHO annual guideline in 2010 (3.0 times more likely in 2000). Findings suggest that absolute NO2 exposure disparities by race-ethnicity decreased from 2000 to 2010, but relative NO2 exposure disparities persisted, with higher NO2 concentrations for nonwhites than whites in 2010. https://doi.org/10.1289/EHP959.

Estimation and Uncertainty Analysis of Impacts of Future Heat Waves on Mortality in the Eastern United States

PubMed Central

Wu, Jianyong; Zhou, Ying; Gao, Yang; Fu, Joshua S.; Johnson, Brent A.; Huang, Cheng; Kim, Young-Min

2013-01-01

Background: Climate change is anticipated to influence heat-related mortality in the future. However, estimates of excess mortality attributable to future heat waves are subject to large uncertainties and have not been projected under the latest greenhouse gas emission scenarios. Objectives: We estimated future heat wave mortality in the eastern United States (approximately 1,700 counties) under two Representative Concentration Pathways (RCPs) and investigated sources of uncertainty. Methods: Using dynamically downscaled hourly temperature projections for 2057–2059, we projected heat wave days that were defined using four heat wave metrics and estimated the excess mortality attributable to them. We apportioned the sources of uncertainty in excess mortality estimates using a variance-decomposition method. Results: Estimates suggest that excess mortality attributable to heat waves in the eastern United States would result in 200–7,807 deaths/year (mean 2,379 deaths/year) in 2057–2059. Average excess mortality projections under RCP4.5 and RCP8.5 scenarios were 1,403 and 3,556 deaths/year, respectively. Excess mortality would be relatively high in the southern states and eastern coastal areas (excluding Maine). The major sources of uncertainty were the relative risk estimates for mortality on heat wave versus non–heat wave days, the RCP scenarios, and the heat wave definitions. Conclusions: Mortality risks from future heat waves may be an order of magnitude higher than the mortality risks reported in 2002–2004, with thousands of heat wave–related deaths per year in the study area projected under the RCP8.5 scenario. Substantial spatial variability in county-level heat mortality estimates suggests that effective mitigation and adaptation measures should be developed based on spatially resolved data. Citation: Wu J, Zhou Y, Gao Y, Fu JS, Johnson BA, Huang C, Kim YM, Liu Y. 2014. Estimation and uncertainty analysis of impacts of future heat waves on mortality in the eastern United States. Environ Health Perspect 122:10–16; http://dx.doi.org/10.1289/ehp.1306670 PMID:24192064

Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition

PubMed Central

Collins, Kevin M; Bode, Addys; Fernandez, Robert W; Tanis, Jessica E; Brewer, Jacob C; Creamer, Matthew S; Koelle, Michael R

2016-01-01

Like many behaviors, Caenorhabditis elegans egg laying alternates between inactive and active states. To understand how the underlying neural circuit turns the behavior on and off, we optically recorded circuit activity in behaving animals while manipulating circuit function using mutations, optogenetics, and drugs. In the active state, the circuit shows rhythmic activity phased with the body bends of locomotion. The serotonergic HSN command neurons initiate the active state, but accumulation of unlaid eggs also promotes the active state independent of the HSNs. The cholinergic VC motor neurons slow locomotion during egg-laying muscle contraction and egg release. The uv1 neuroendocrine cells mechanically sense passage of eggs through the vulva and release tyramine to inhibit egg laying, in part via the LGC-55 tyramine-gated Cl- channel on the HSNs. Our results identify discrete signals that entrain or detach the circuit from the locomotion central pattern generator to produce active and inactive states. DOI: http://dx.doi.org/10.7554/eLife.21126.001 PMID:27849154

Depth of interaction determination in monolithic scintillator with double side SiPM readout.

PubMed

Morrocchi, Matteo; Ambrosi, Giovanni; Bisogni, Maria Giuseppina; Bosi, Filippo; Boretto, Marco; Cerello, Piergiorgio; Ionica, Maria; Liu, Ben; Pennazio, Francesco; Piliero, Maria Antonietta; Pirrone, Giovanni; Postolache, Vasile; Wheadon, Richard; Del Guerra, Alberto

2017-12-01

Monolithic scintillators read out by arrays of photodetectors represent a promising solution to obtain high spatial resolution and the depth of interaction (DOI) of the annihilation photon. We have recently investigated a detector geometry composed of a monolithic scintillator readout on two sides by silicon photomultiplier (SiPM) arrays, and we have proposed two parameters for the DOI determination: the difference in the number of triggered SiPMs on the two sides of the detector and the difference in the maximum collected signal on a single SiPM on each side. This work is focused on the DOI calibration and on the determination of the capability of our detector. For the DOI calibration, we studied a method which can be implemented also in detectors mounted in a full PET scanner. We used a PET detector module composed of a monolithic 20 × 20 × 10 mm 3 LYSO scintillator crystal coupled on two opposite faces to two arrays of SiPMs. On each side, the scintillator was coupled to 6 × 6 SiPMs. In this paper, the two parameters previously proposed for the DOI determination were calibrated with two different methods. The first used a lateral scan of the detector with a collimated 511 keV pencil beam at steps of 0.5 mm to study the detector DOI capability, while the second used the background radiation of the 176 Lu in the scintillator. The DOI determination capability was tested on different regions of the detector using each parameter and the combination of the two. With both parameters for the DOI determination, in the lateral scan, the bias between the mean reconstructed DOI and the real beam position was lower than 0.3 mm, and the DOI distribution had a standard deviation of about 1.5 mm. When using the calibration with the radioactivity of the LYSO, the mean bias increased of about 0.2 mm but with no degradation of the standard deviation of the DOI distribution. The two parameters allow to achieve a DOI resolution comparable with the state of the art, giving a continuous information about the three-dimensional interaction position of the scintillation. These results were obtained by using simple estimators and a detector scalable to a whole PET system. The DOI calibration obtained using lutetium natural radioactivity gives results comparable to the other standard method but appears more readily applicable to detectors mounted in a full PET scanner.

U.S. Department of the Interior Southeast Climate Science Center Science and Operational Plan

USGS Publications Warehouse

Jones, Sonya A.; Dalton, Melinda S.

2012-01-01

Climate change challenges many of the basic assumptions routinely used by conservation planners and managers, including the identification and prioritization of areas for conservation based on current environmental conditions and the assumption those conditions could be controlled by management actions. Climate change will likely alter important ecosystem drivers (temperature, precipitation, and sea-level rise) and make it difficult, if not impossible, to maintain current environmental conditions into the future. Additionally, the potential for future conservation of non-conservation lands may be affected by climate change, which further complicates resource planning. Potential changes to ecosystem drivers, as a result of climate change, highlight the need to develop and adapt effective conservation strategies to cope with the effects of climate and landscape change. The U.S. Congress, recognized the potential effects of climate change and authorized the creation of the U.S. Geological Survey National Climate Change and Wildlife Science Center (NCCWSC) in 2008. The directive of the NCCWSC is to produce science that supports resource-management agencies as they anticipate and adapt to the effects of climate change on fish, wildlife, and their habitats. On September 14, 2009, U.S. Department of the Interior (DOI) Secretary Ken Salazar signed Secretarial Order 3289 (amended February 22, 2010), which expanded the mandate of the NCCWSC to address climate-change-related impacts on all DOI resources. Secretarial Order 3289 "Addressing the Impacts of Climate Change on America's Water, Land, and Other Natural and Cultural Resources," established the foundation of two partner-based conservation science entities: Climate Science Centers (CSC) and their primary partners, Landscape Conservation Cooperatives (LCC). CSCs and LCCs are the Department-wide approach for applying scientific tools to increase the understanding of climate change, and to coordinate an effective response to its impacts on tribes and the land, water, ocean, fish and wildlife, and cultural-heritage resources that DOI manages. The NCCWSC is establishing a network of eight DOI CSCs (Alaska, Southeast, Northwest, North Central, Pacific Islands, Southwest, Northeast, and South Central) that will work with a variety of partners and stakeholders to provide resource managers the tools and information they need to help them anticipate and adapt conservation planning and design for projected climate change. The Southeast CSC, a federally led research collaboration hosted by North Carolina State University, was established in 2010. The Southeast CSC brings together the expertise of federal and university scientists to address climate-change priority needs of federal, state, non-governmental, and tribal resource managers. This document is the first draft of a science and operational plan for the Southeast CSC. The document describes operational considerations, provides the context for climate-change impacts in the Southeastern United States, and establishes six major science themes the Southeast CSC will address in collaboration with partners. This document is intended to be reevaluated and modified as partner needs change.

Evolution of record-breaking high and low monthly mean temperatures

NASA Astrophysics Data System (ADS)

Anderson, A. L.; Kostinski, A. B.

2011-12-01

We examine the ratio of record-breaking highs to record-breaking lows with respect to extent of time-series for monthly mean temperatures within the continental United States (1900-2006) and ask the following question. How are record-breaking high and low surface temperatures in the United States affected by time period? We find that the ratio of record-breaking highs to lows in 2006 increases as the time-series extend further into the past. For example: in 2006, the ratio of record-breaking highs to record-breaking lows is ≈ 13 : 1 with 1950 as the first year and ≈ 25 : 1 with 1900 as the first year; both ratios are an order of magnitude greater than 3-σ for stationary simulations. We also find record-breaking events are more sensitive to trends in time-series of monthly averages than time-series of corresponding daily values. When we consider the ratio as it evolves with respect to a fixed start year, we find it is strongly correlated with the ensemble mean. Correlation coefficients are 0.76 and 0.82 for 1900-2006 and 1950-2006 respectively; 3-σ = 0.3 for pairs of uncorrelated stationary time-series. We find similar values for globally distributed time-series: 0.87 and 0.92 for 1900-2006 and 1950-2006 respectively. However, the ratios evolve differently: global ratios increase throughout (1920-2006) while continental United States ratios decrease from about 1940 to 1970. (Based on Anderson and Kostinski (2011), Evolution and distribution of record-breaking high and low monthly mean temperatures. Journal of Applied Meteorology and Climatology. doi: 10.1175/JAMC-D-10-05025.1)

Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

PubMed Central

Gaiti, Federico; Jindrich, Katia; Fernandez-Valverde, Selene L; Roper, Kathrein E; Degnan, Bernard M; Tanurdžić, Miloš

2017-01-01

Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity. DOI: http://dx.doi.org/10.7554/eLife.22194.001 PMID:28395144

Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

PubMed Central

Sunden, Fanny; Peck, Ariana; Salzman, Julia; Ressl, Susanne; Herschlag, Daniel

2015-01-01

Enzymes enable life by accelerating reaction rates to biological timescales. Conventional studies have focused on identifying the residues that have a direct involvement in an enzymatic reaction, but these so-called ‘catalytic residues’ are embedded in extensive interaction networks. Although fundamental to our understanding of enzyme function, evolution, and engineering, the properties of these networks have yet to be quantitatively and systematically explored. We dissected an interaction network of five residues in the active site of Escherichia coli alkaline phosphatase. Analysis of the complex catalytic interdependence of specific residues identified three energetically independent but structurally interconnected functional units with distinct modes of cooperativity. From an evolutionary perspective, this network is orders of magnitude more probable to arise than a fully cooperative network. From a functional perspective, new catalytic insights emerge. Further, such comprehensive energetic characterization will be necessary to benchmark the algorithms required to rationally engineer highly efficient enzymes. DOI: http://dx.doi.org/10.7554/eLife.06181.001 PMID:25902402

Five-year external reviews of the eight Department of Interior Climate Science Centers: Southeast Climate Science Center

USGS Publications Warehouse

Rice, Kenneth G.; Beier, Paul; Breault, Tim; Middleton, Beth A.; Peck, Myron A.; Tirpak, John M.; Ratnaswamy, Mary; Austen, Douglas; Harrison, Sarah

2017-01-01

In 2008, the U.S. Congress authorized the establishment of the National Climate Change and Wildlife Science Center (NCCWSC) within the U.S. Department of Interior (DOI). Housed administratively within the U.S. Geological Survey (USGS), NCCWSC is part of the DOI’s ongoing mission to meet the challenges of climate change and its effects on wildlife and aquatic resources. From 2010 through 2012, NCCWSC established eight regional DOI Climate Science Centers (CSCs). Each of these regional CSCs operated with the mission to “synthesize and integrate climate change impact data and develop tools that the Department’s managers and partners can use when managing the Department’s land, water, fish and wildlife, and cultural heritage resources” (Salazar 2009). The model developed by NCCWSC for the regional CSCs employed a dual approach of a federal USGS-staffed component and a parallel host-university component established competitively through a 5-year cooperative agreement with NCCWSC. At the conclusion of this 5-year agreement, a review of each CSC was undertaken, with the Southeast Climate Science Center (SE CSC) review in February 2016. The SE CSC is hosted by North Carolina State University (NCSU) in Raleigh, North Carolina, and is physically housed within the NCSU Department of Applied Ecology along with the Center for Applied Aquatic Ecology, the North Carolina Cooperative Fish and Wildlife Research Unit (CFWRU), and the North Carolina Agromedicine Institute. The U.S. Department of Agriculture Southeast Regional Climate Hub is based at NCSU as is the National Oceanic and Atmospheric Administration (NOAA) Southeast Regional Climate Center, the North Carolina Institute for Climate Studies, the North Carolina Wildlife Resources Commission, the NOAA National Weather Service, the State Climate Office of North Carolina, and the U.S. Forest Service Eastern Forest Environmental Threat Assessment Center. This creates a strong core of organizations operating in close proximity focused on climate issues. The geographic area covered by the SE CSC represents all or part of 16 states and the Caribbean Islands and has overlapping boundaries with seven Landscape Conservation Cooperatives (LCCs): Appalachian LCC, Eastern Tallgrass Prairie and Big Rivers LCC, Gulf Coast Prairie LCC, Gulf Coastal Plains and Ozarks LCC, Peninsular Florida LCC, South Atlantic LCC, and Caribbean LCC. The SE CSC region also encompasses 134 U.S. Fish and Wildlife Service refuges and 89 National Park Service (NPS) units and is home to 11 federally recognized and 54 state recognized tribes. 

Race/Ethnicity, Socioeconomic Status, Residential Segregation, and Spatial Variation in Noise Exposure in the Contiguous United States.

PubMed

Casey, Joan A; Morello-Frosch, Rachel; Mennitt, Daniel J; Fristrup, Kurt; Ogburn, Elizabeth L; James, Peter

2017-07-25

Prior research has reported disparities in environmental exposures in the United States, but, to our knowledge, no nationwide studies have assessed inequality in noise pollution. We aimed to a ) assess racial/ethnic and socioeconomic inequalities in noise pollution in the contiguous United States; and b ) consider the modifying role of metropolitan level racial residential segregation. We used a geospatial sound model to estimate census block group–level median (L 50 ) nighttime and daytime noise exposure and 90th percentile (L 10 ) daytime noise exposure. Block group variables from the 2006–2010 American Community Survey (ACS) included race/ethnicity, education, income, poverty, unemployment, homeownership, and linguistic isolation. We estimated associations using polynomial terms in spatial error models adjusted for total population and population density. We also evaluated the relationship between race/ethnicity and noise, stratified by levels of metropolitan area racial residential segregation, classified using a multigroup dissimilarity index. Generally, estimated nighttime and daytime noise levels were higher for census block groups with higher proportions of nonwhite and lower-socioeconomic status (SES) residents. For example, estimated nighttime noise levels in urban block groups with 75% vs. 0% black residents were 46.3 A-weighted decibels (dBA) [interquartile range (IQR): 44.3–47.8 dBA] and 42.3 dBA (IQR: 40.4–45.5 dBA), respectively. In urban block groups with 50% vs. 0% of residents living below poverty, estimated nighttime noise levels were 46.9 dBA (IQR: 44.7–48.5 dBA) and 44.0 dBA (IQR: 42.2–45.5 dBA), respectively. Block groups with the highest metropolitan area segregation had the highest estimated noise exposures, regardless of racial composition. Results were generally consistent between urban and suburban/rural census block groups, and for daytime and nighttime noise and robust to different spatial weight and neighbor definitions. We found evidence of racial/ethnic and socioeconomic differences in model-based estimates of noise exposure throughout the United States. Additional research is needed to determine if differences in noise exposure may contribute to health disparities in the United States. https://doi.org/10.1289/EHP898

Race/Ethnicity, Socioeconomic Status, Residential Segregation, and Spatial Variation in Noise Exposure in the Contiguous United States

PubMed Central

Morello-Frosch, Rachel; Mennitt, Daniel J.; Fristrup, Kurt; Ogburn, Elizabeth L.; James, Peter

2017-01-01

Background: Prior research has reported disparities in environmental exposures in the United States, but, to our knowledge, no nationwide studies have assessed inequality in noise pollution. Objectives: We aimed to a) assess racial/ethnic and socioeconomic inequalities in noise pollution in the contiguous United States; and b) consider the modifying role of metropolitan level racial residential segregation. Methods: We used a geospatial sound model to estimate census block group–level median (L50) nighttime and daytime noise exposure and 90th percentile (L10) daytime noise exposure. Block group variables from the 2006–2010 American Community Survey (ACS) included race/ethnicity, education, income, poverty, unemployment, homeownership, and linguistic isolation. We estimated associations using polynomial terms in spatial error models adjusted for total population and population density. We also evaluated the relationship between race/ethnicity and noise, stratified by levels of metropolitan area racial residential segregation, classified using a multigroup dissimilarity index. Results: Generally, estimated nighttime and daytime noise levels were higher for census block groups with higher proportions of nonwhite and lower-socioeconomic status (SES) residents. For example, estimated nighttime noise levels in urban block groups with 75% vs. 0% black residents were 46.3 A-weighted decibels (dBA) [interquartile range (IQR): 44.3–47.8 dBA] and 42.3 dBA (IQR: 40.4–45.5 dBA), respectively. In urban block groups with 50% vs. 0% of residents living below poverty, estimated nighttime noise levels were 46.9 dBA (IQR: 44.7–48.5 dBA) and 44.0 dBA (IQR: 42.2–45.5 dBA), respectively. Block groups with the highest metropolitan area segregation had the highest estimated noise exposures, regardless of racial composition. Results were generally consistent between urban and suburban/rural census block groups, and for daytime and nighttime noise and robust to different spatial weight and neighbor definitions. Conclusions: We found evidence of racial/ethnic and socioeconomic differences in model-based estimates of noise exposure throughout the United States. Additional research is needed to determine if differences in noise exposure may contribute to health disparities in the United States. https://doi.org/10.1289/EHP898 PMID:28749369

Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states

PubMed Central

Jang, Sumin; Choubey, Sandeep; Furchtgott, Leon; Zou, Ling-Nan; Doyle, Adele; Menon, Vilas; Loew, Ethan B; Krostag, Anne-Rachel; Martinez, Refugio A; Madisen, Linda; Levi, Boaz P; Ramanathan, Sharad

2017-01-01

The complexity of gene regulatory networks that lead multipotent cells to acquire different cell fates makes a quantitative understanding of differentiation challenging. Using a statistical framework to analyze single-cell transcriptomics data, we infer the gene expression dynamics of early mouse embryonic stem (mES) cell differentiation, uncovering discrete transitions across nine cell states. We validate the predicted transitions across discrete states using flow cytometry. Moreover, using live-cell microscopy, we show that individual cells undergo abrupt transitions from a naïve to primed pluripotent state. Using the inferred discrete cell states to build a probabilistic model for the underlying gene regulatory network, we further predict and experimentally verify that these states have unique response to perturbations, thus defining them functionally. Our study provides a framework to infer the dynamics of differentiation from single cell transcriptomics data and to build predictive models of the gene regulatory networks that drive the sequence of cell fate decisions during development. DOI: http://dx.doi.org/10.7554/eLife.20487.001 PMID:28296635

A Brief History of Soil Mapping and Classification in the USA

NASA Astrophysics Data System (ADS)

Brevik, Eric C.; Hartemink, Alfred E.

2014-05-01

Soil maps show the distribution of soils across an area but also depict soil science theory and ideas on soil formation and classification at the time the maps were created. The national soil mapping program in the USA was established in 1899. The first nation-wide soil map was published by M. Whitney in 1909 and showed soil provinces that were largely based on geology. In 1912, G.N. Coffey published the first country-wide map based on soil properties. The map showed 5 broad soil units that used parent material, color and drainage as diagnostic criteria. The 1913 national map was produced by C.F. Marbut, H.H. Bennett, J.E. Lapham, and M.H. Lapham and showed broad physiographic units that were further subdivided into soil series, soil classes and soil types. In 1935, Marbut drafted a series of maps based on soil properties, but these maps were replaced as official U.S. soil maps in 1938 with the work of M. Baldwin, C.E. Kellogg, and J. Thorp. A series of soil maps similar to modern USA maps appeared in the 1960s with the 7th Approximation followed by revisions with the 1975 and 1999 editions of Soil Taxonomy. This review has shown that soil maps in the United States produced since the early 1900s moved initially from a geologic-based concept to a pedologic concept of soils. Later changes were from property-based systems to process-based, and then back to property-based. The information in this presentation is based on Brevik and Hartemink (2013). Brevik, E.C., and A.E. Hartemink. 2013. Soil Maps of the United States of America. Soil Science Society of America Journal 77:1117-1132. doi:10.2136/sssaj2012.0390.

STS-87 Columbia landing at KSC

NASA Technical Reports Server (NTRS)

1997-01-01

With Commander Kevin Kregel and Pilot Steven Lindsey at the controls, the orbiter Columbia makes a smooth touchdown on Runway 33 at KSCs Shuttle Landing Facility at 7:20:04 a.m. EST Dec. 5, completing the 15-day, 16-hour and 34-minute-long STS-87 mission of 6.5 million miles. Also onboard the orbiter are Mission Specialists Winston Scott; Kalpana Chawla, Ph.D.; and Takao Doi, Ph.D., of the National Space Development Agency of Japan; along with Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

Plantar Fasciitis: Will Physical Therapy Help My Foot Pain?

PubMed

2017-02-01

One out of 10 people in the United States experience persistent pain along the bottom of the foot, a condition known as plantar fasciitis. In 2014, the Orthopaedic Section of the American Physical Therapy Association published updated clinical practice guidelines on the best treatments for patients with plantar fasciitis. The guidelines present evidence that strongly suggests a combination of manual therapy and rehabilitative exercises to help patients with this foot condition. In a more recent study published in the February 2017 issue of JOSPT, researchers reviewed the records of people with plantar fasciitis who were sent to physical therapy. The results of this study support prior studies that show faster recovery time for those who receive evidence-based physical therapy for their foot pain. J Orthop Sports Phys Ther 2017;47(2):56. doi:10.2519/jospt.2017.0501.

A machine learning method for fast and accurate characterization of depth-of-interaction gamma cameras

NASA Astrophysics Data System (ADS)

Pedemonte, Stefano; Pierce, Larry; Van Leemput, Koen

2017-11-01

Measuring the depth-of-interaction (DOI) of gamma photons enables increasing the resolution of emission imaging systems. Several design variants of DOI-sensitive detectors have been recently introduced to improve the performance of scanners for positron emission tomography (PET). However, the accurate characterization of the response of DOI detectors, necessary to accurately measure the DOI, remains an unsolved problem. Numerical simulations are, at the state of the art, imprecise, while measuring directly the characteristics of DOI detectors experimentally is hindered by the impossibility to impose the depth-of-interaction in an experimental set-up. In this article we introduce a machine learning approach for extracting accurate forward models of gamma imaging devices from simple pencil-beam measurements, using a nonlinear dimensionality reduction technique in combination with a finite mixture model. The method is purely data-driven, not requiring simulations, and is applicable to a wide range of detector types. The proposed method was evaluated both in a simulation study and with data acquired using a monolithic gamma camera designed for PET (the cMiCE detector), demonstrating the accurate recovery of the DOI characteristics. The combination of the proposed calibration technique with maximum- a posteriori estimation of the coordinates of interaction provided a depth resolution of  ≈1.14 mm for the simulated PET detector and  ≈1.74 mm for the cMiCE detector. The software and experimental data are made available at http://occiput.mgh.harvard.edu/depthembedding/.

The nodal count {0,1,2,3,…} implies the graph is a tree

PubMed Central

Band, Ram

2014-01-01

Sturm's oscillation theorem states that the nth eigenfunction of a Sturm–Liouville operator on the interval has n−1 zeros (nodes) (Sturm 1836 J. Math. Pures Appl. 1, 106–186; 373–444). This result was generalized for all metric tree graphs (Pokornyĭ et al. 1996 Mat. Zametki 60, 468–470 (doi:10.1007/BF02320380); Schapotschnikow 2006 Waves Random Complex Media 16, 167–178 (doi:10.1080/1745530600702535)) and an analogous theorem was proved for discrete tree graphs (Berkolaiko 2007 Commun. Math. Phys. 278, 803–819 (doi:10.1007/S00220-007-0391-3); Dhar & Ramaswamy 1985 Phys. Rev. Lett. 54, 1346–1349 (doi:10.1103/PhysRevLett.54.1346); Fiedler 1975 Czechoslovak Math. J. 25, 607–618). We prove the converse theorems for both discrete and metric graphs. Namely if for all n, the nth eigenfunction of the graph has n−1 zeros, then the graph is a tree. Our proofs use a recently obtained connection between the graph's nodal count and the magnetic stability of its eigenvalues (Berkolaiko 2013 Anal. PDE 6, 1213–1233 (doi:10.2140/apde.2013.6.1213); Berkolaiko & Weyand 2014 Phil. Trans. R. Soc. A 372, 20120522 (doi:10.1098/rsta.2012.0522); Colin de Verdière 2013 Anal. PDE 6, 1235–1242 (doi:10.2140/apde.2013.6.1235)). In the course of the proof, we show that it is not possible for all (or even almost all, in the metric case) the eigenvalues to exhibit a diamagnetic behaviour. In addition, we develop a notion of ‘discretized’ versions of a metric graph and prove that their nodal counts are related to those of the metric graph. PMID:24344337

A Data mining and Meta-Analysis of Geodiversity and Geological Preservation Studies: Pedodiversity, the Other Side of the Coin

NASA Astrophysics Data System (ADS)

Ibáñez, Juanjo; Brevik, Eric C.; Cerdà, Artemi

2017-04-01

Land degradation processes are complex and diverse (Yan and Cai, 2015; Álvarez-Martínez et al., 2016; Zhang et al., 2016). To understand the processes of degradation there is the need to understand a wide range of factors, including the sociological, biological, hydrological and geological components of the ecosystems (de Araujo et al., 2015; Li et al., 2016; Muñoz Rojas et al., 2016; Rodrigo Comino et al., 2016). Although the most widely accepted definitions of geodiversity include geology, landforms and soils, in practice published studies on the preservation of geodiversity typically ignore the soil resource and pay more attention to other items, while many others do not include soils in such definitions. Soils are a key component of the Earth system as they regulate the hydrological, erosional, biological and geochemical Earth cycles (Keesstra et al., 2012; Brevik et al., 2015), offer resources, goods and services to human societies (Mol and Keesstra, 2012), and are a key issue in the United Nations goals to achieve sustainability (Keesstra et al., 2016). The preservation of pedodiversity is practically ignored by governments. The same can be said in the acceptance of geoparks by UNESCO, when soils are ignored. A few researchers have paid attention to geodiversity (Ibáñez et al., 2016; Stavi et al., 2016). In this study a data mining and metanalysis of this topic has been carried out using four different sources; Google, Google Scholar, Scopus, and the contents of Geoheritage journal. The results obtained show the same trends in all four studied sources. Soil resources are neglected in geodiversity studies as well as in the preservation of geological heritage against the scientific rationality inherent in the definition of geodiversity. Furthermore, pedodiversity studies have been carried out by a small set of interested pedologists following the same conceptual frames and mathematical tools reaching interesting universal patterns and a common language, whereas initiatives directed at the quantification of geodiversity have not reached the development of a single or a small set of methodologies accepted by experts. Thus, while pedologists can compare the diversity of soil resources as well as pedodiversity and biodiversity relationships in different regions and environments, the reverse is not true in geodiversity analysis. The authors' analysis of the state of the art, comparing it with what happened in the history of biodiversity research, led to the conclusion that the opportunism and vogue have dominated scientific rationality. There is not a geodiversity paradigm as some geodiversity experts contend and defend but rather a plethora of publications whose results are hardly comparable. This state-of-the-art shows the other side of the coin, which is the challenge of and future opportunities for research about geodiversity to contribute to the development of societies affected by land degradation processes. Acknowledgements This research received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n_ 603498 (RECARE project) and the CGL2013- 47862-C2-1-R and CGL2016-75178-C2-2-R national research projects. References Álvarez-Martínez, J., Gómez-Villar, A., and Lasanta, T. 2016. The use of goats grazing to restore pastures invaded by shrubs and avoid desertification: A preliminary case study in the Spanish Cantabria Mountains. Land Degradation and Development 27(1), 3-13. doi:10.1002/ldr.2230 Brevik, E.C., Cerdà, A., Mataix-Solera, J., Pereg, L., Quinton, J.N., Six, J., and Van Oost, K. 2015. The interdisciplinary nature of SOIL, SOIL, 1, 117-129, doi:10.5194/soil-1-117-2015, de Araújo, A.S.F., Eisenhauer, N., Nunes, L.A.P.L., Leite, L.F.C. and Cesarz, S. 2015. Soil Surface-Active Fauna in Degraded and Restored Lands of Northeast Brazil. Land Degradation and Development 26(1), 1-8. doi:10.1002/ldr.2247. Ibáñez, J.J., Pérez-Gómez, R., Brevik, E.C., and Cerdà, A. 2016. Islands of biogeodiversity in arid lands on a polygons map study: Detecting scale invariance patterns from natural resources maps. Science of the Total Environment 573, 1638-1647. doi:10.1016/j.scitotenv.2016.09.172 Keesstra, S.D., Bouma, J., Wallinga, J., Tittonell, P., Smith, P., Cerdà, A., Montanarella, L., Quinton, J.N., Pachepsky, Y., van der Putten, W.H., Bardgett, R.D., Moolenaar, S., Mol, G., Jansen, B., and Fresco, L.O. 2016. The significance of soils and soil science towards realization of the United Nations Sustainable Development Goals. SOIL 2, 111-128, doi:10.5194/soil-2-111-2016, 2016. Keesstra, S.D., Geissen, V., van Schaik, L., Mosse, K., and Piiranen, S. 2012. Soil as a filter for groundwater quality. Current Opinions in Environmental Sustainability 4, 507-516. doi:10.1016/j.cosust.2012.10.007 Li, Y.B., Li, Q.Y., Luo, G.J., Bai, X.Y., Wang, Y.Y., Wang, S.J., Xie, J., and Yang, G.B. 2016. Discussing the genesis of karst rocky desertification research based on the correlations between cropland and settlements in typical peak-cluster depressions. Solid Earth 7(3), 741-750. DOI: http://dx.doi.org/10.5194/se-7-741-2016 Mol, G., and Keesstra, S.D., 2012. Editorial: Soil science in a changing world. Current Opinions in Environmental Sustainability 4, 473-477. Muñoz-Rojas, M., Erickson, T.E., Martini, D., Dixon, K.D., and Merritt, D.J. 2016. Soil physicochemical and microbiological indicators of short, medium and long term post-fire recovery in semi-arid ecosystems. Ecological Indicators 63, 14-22. doi: 10.1016/j.ecolind.2015.11.038 Rodrigo Comino, J., Quiquerez, A., Follain, S., Raclot, D., Le Bissonnais, Y., Casalí, J., Giménez, R., Cerdà, A., Keesstra, S.D., Brevik, E.C., Pereira, P., Senciales, J.M., Seeger, M., Ruiz Sinoga, J.D., and Ries, J.B. 2016. Soil erosion in sloping vineyards assessed by using botanical indicators and sediment collectors in the Ruwer-Mosel valley. Agriculture Ecosystems and Environment 233, 158-170. DOI: 10.1016/j.agee.2016.09.009 Stavi, I., Rachmilevitch, S., and Yizhaq, H. 2016. Small-scale geodiversity regulates functioning, connectivity, and productivity of shrubby, semi-arid rangelands. Land Degradation and Development, doi:10.1002/ldr.2469 Yan, X., and Cai, Y.L. 2015. Multi-scale anthropogenic driving forces of karst rocky desertification in southwest China. Land Degradation and Development 26(2), 193-200. doi:10.1002/ldr.2209 Zhang, K., An, Z., Cai, D., Guo, Z., and Xiao, J. 2016. Key role of desert-oasis transitional area in avoiding oasis land degradation from aeolian desertification in Dunhuang, northwest China. Land Degradation and Development, doi:10.1002/ldr.2584

Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

PubMed Central

Armbruster, Moritz; Messa, Mirko; Ferguson, Shawn M; De Camilli, Pietro; Ryan, Timothy A

2013-01-01

Modulation of synaptic vesicle retrieval is considered to be potentially important in steady-state synaptic performance. Here we show that at physiological temperature endocytosis kinetics at hippocampal and cortical nerve terminals show a bi-phasic dependence on electrical activity. Endocytosis accelerates for the first 15–25 APs during bursts of action potential firing, after which it slows with increasing burst length creating an optimum stimulus for this kinetic parameter. We show that activity-dependent acceleration is only prominent at physiological temperature and that the mechanism of this modulation is based on the dephosphorylation of dynamin 1. Nerve terminals in which dynamin 1 and 3 have been replaced with dynamin 1 harboring dephospho- or phospho-mimetic mutations in the proline-rich domain eliminate the acceleration phase by either setting endocytosis at an accelerated state or a decelerated state, respectively. DOI: http://dx.doi.org/10.7554/eLife.00845.001 PMID:23908769

Robot Path Planning in Uncertain Environments: A Language-Measure-Theoretic Approach

DTIC Science & Technology

2015-03-01

in the framework of probabilistic finite state automata (PFSA) and language measure from a control-theoretic perspective. The proposed concept has been...DOI: 10.1115/1.4027876] Keywords: path planning, language measure, probabilistic finite state automata 1 Motivation and Introduction In general

Decoding a neural circuit controlling global animal state in C. elegans

PubMed Central

Laurent, Patrick; Soltesz, Zoltan; Nelson, Geoffrey M; Chen, Changchun; Arellano-Carbajal, Fausto; Levy, Emmanuel; de Bono, Mario

2015-01-01

Brains organize behavior and physiology to optimize the response to threats or opportunities. We dissect how 21% O2, an indicator of surface exposure, reprograms C. elegans' global state, inducing sustained locomotory arousal and altering expression of neuropeptides, metabolic enzymes, and other non-neural genes. The URX O2-sensing neurons drive arousal at 21% O2 by tonically activating the RMG interneurons. Stimulating RMG is sufficient to switch behavioral state. Ablating the ASH, ADL, or ASK sensory neurons connected to RMG by gap junctions does not disrupt arousal. However, disrupting cation currents in these neurons curtails RMG neurosecretion and arousal. RMG signals high O2 by peptidergic secretion. Neuropeptide reporters reveal neural circuit state, as neurosecretion stimulates neuropeptide expression. Neural imaging in unrestrained animals shows that URX and RMG encode O2 concentration rather than behavior, while the activity of downstream interneurons such as AVB and AIY reflect both O2 levels and the behavior being executed. DOI: http://dx.doi.org/10.7554/eLife.04241.001 PMID:25760081

Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

PubMed Central

Bellay, Timothy; Klaus, Andreas; Seshadri, Saurav; Plenz, Dietmar

2015-01-01

Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity. DOI: http://dx.doi.org/10.7554/eLife.07224.001 PMID:26151674

Ventromedial hypothalamic neurons control a defensive emotion state

PubMed Central

Kunwar, Prabhat S; Zelikowsky, Moriel; Remedios, Ryan; Cai, Haijiang; Yilmaz, Melis; Meister, Markus; Anderson, David J

2015-01-01

Defensive behaviors reflect underlying emotion states, such as fear. The hypothalamus plays a role in such behaviors, but prevailing textbook views depict it as an effector of upstream emotion centers, such as the amygdala, rather than as an emotion center itself. We used optogenetic manipulations to probe the function of a specific hypothalamic cell type that mediates innate defensive responses. These neurons are sufficient to drive multiple defensive actions, and required for defensive behaviors in diverse contexts. The behavioral consequences of activating these neurons, moreover, exhibit properties characteristic of emotion states in general, including scalability, (negative) valence, generalization and persistence. Importantly, these neurons can also condition learned defensive behavior, further refuting long-standing claims that the hypothalamus is unable to support emotional learning and therefore is not an emotion center. These data indicate that the hypothalamus plays an integral role to instantiate emotion states, and is not simply a passive effector of upstream emotion centers. DOI: http://dx.doi.org/10.7554/eLife.06633.001 PMID:25748136

RETRACTED: An overview of mathematical modeling of electrochemical supercapacitors/ultracapacitors

NASA Astrophysics Data System (ADS)

Ike, Innocent S.; Sigalas, Iakovos; Iyuke, Sunny; Ozoemena, Kenneth I.

2015-01-01

This article has been retracted at the request of the Editor-in-Chief, with agreement of the authors: please see Elsevier Policy on Article Withdrawal. Substantial parts of this review paper are similar to the texts of existing papers in the literature. The co-authors state that the corresponding author submitted the manuscript without their approval. The following works are affected: IEEE Transactions on Power Electronics, 26 (2011) 3472-3480, http://dx.doi.org/10.1109/TPEL.2011.2161096 The Journal of Physical Chemistry Letters, 4 (2013) 1260-1267, http://dx.doi.org/10.1021/jz4002967 The Journal of Physical Chemistry Letters, 4 (2013), 3367-3376, http://dx.doi.org/10.1021/jz4014163 Physical Chemistry Chemical Physics, 16 (2014), 6519-6538, http://dx.doi.org/10.1039/c3cp55186e The Authors unreservedly apologise for this violation of the publishing policies, and offer sincere apologies to the parties affected. The journal apologises to its readers and the authors that the overlap was not detected during the submission and review process.

Hydrography and biogeochemistry dedicated to the Mediterranean BGC-Argo network during a cruise with RV Tethys 2 in May 2015

NASA Astrophysics Data System (ADS)

Taillandier, Vincent; Wagener, Thibaut; D'Ortenzio, Fabrizio; Mayot, Nicolas; Legoff, Hervé; Ras, Joséphine; Coppola, Laurent; Pasqueron de Fommervault, Orens; Schmechtig, Catherine; Diamond, Emilie; Bittig, Henry; Lefevre, Dominique; Leymarie, Edouard; Poteau, Antoine; Prieur, Louis

2018-03-01

We report on data from an oceanographic cruise, covering western, central and eastern parts of the Mediterranean Sea, on the French research vessel Tethys 2 in May 2015. This cruise was fully dedicated to the maintenance and the metrological verification of a biogeochemical observing system based on a fleet of BGC-Argo floats. During the cruise, a comprehensive data set of parameters sensed by the autonomous network was collected. The measurements include ocean currents, seawater salinity and temperature, and concentrations of inorganic nutrients, dissolved oxygen and chlorophyll pigments. The analytical protocols and data processing methods are detailed, together with a first assessment of the calibration state for all the sensors deployed during the cruise. Data collected at stations are available at https://doi.org/10.17882/51678 and data collected along the ship track are available at https://doi.org/10.17882/51691.

Improvements in Diagnostic Accuracy with Quantitative Dynamic Contrast-Enhanced MRI

DTIC Science & Technology

2014-03-01

values   With the fat B1 map it is now possible to obtain a B1 map for the whole field of view. To do this we have been testing software to...10.1002/ mrm .21120. 7. Nehrke K. On the steady-state properties of actual flip angle imaging (AFI). Magn. Reson. Med. 2009;61:84–92. doi: 10.1002/ mrm ...by bilateral dynamic contrast‐enhanced MRI: A sensitivity and specificity study. Magn. … 2008;59:747–54. doi: 10.1002/ mrm .21530. 11. Hylton N

An Evaluation of Semiempirical Models for Partitioning Photosynthetically Active Radiation Into Diffuse and Direct Beam Components

NASA Astrophysics Data System (ADS)

Oliphant, Andrew J.; Stoy, Paul C.

2018-03-01

Photosynthesis is more efficient under diffuse than direct beam photosynthetically active radiation (PAR) per unit PAR, but diffuse PAR is infrequently measured at research sites. We examine four commonly used semiempirical models (Erbs et al., 1982, https://doi.org/10.1016/0038-092X(82)90302-4; Gu et al., 1999, https://doi.org/10.1029/1999JD901068; Roderick, 1999, https://doi.org/10.1016/S0168-1923(99)00028-3; Weiss & Norman, 1985, https://doi.org/10.1016/0168-1923(85)90020-6) that partition PAR into diffuse and direct beam components based on the negative relationship between atmospheric transparency and scattering of PAR. Radiation observations at 58 sites (140 site years) from the La Thuille FLUXNET data set were used for model validation and coefficient testing. All four models did a reasonable job of predicting the diffuse fraction of PAR (ϕ) at the 30 min timescale, with site median r2 values ranging between 0.85 and 0.87, model efficiency coefficients (MECs) between 0.62 and 0.69, and regression slopes within 10% of unity. Model residuals were not strongly correlated with astronomical or standard meteorological variables. We conclude that the Roderick (1999, https://doi.org/10.1016/S0168-1923(99)00028-3) and Gu et al. (1999, https://doi.org/10.1029/1999JD901068) models performed better overall than the two older models. Using the basic form of these models, the data set was used to find both individual site and universal model coefficients that optimized predictive accuracy. A new universal form of the model is presented in section 5 that increased site median MEC to 0.73. Site-specific model coefficients increased median MEC further to 0.78, indicating usefulness of local/regional training of coefficients to capture the local distributions of aerosols and cloud types.

An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

PubMed Central

Schütte, Judith; Wang, Huange; Antoniou, Stella; Jarratt, Andrew; Wilson, Nicola K; Riepsaame, Joey; Calero-Nieto, Fernando J; Moignard, Victoria; Basilico, Silvia; Kinston, Sarah J; Hannah, Rebecca L; Chan, Mun Chiang; Nürnberg, Sylvia T; Ouwehand, Willem H; Bonzanni, Nicola; de Bruijn, Marella FTR; Göttgens, Berthold

2016-01-01

Transcription factor (TF) networks determine cell-type identity by establishing and maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory network models has been hampered by a lack of comprehensive functional validation of regulatory interactions. Here, we report comprehensive ChIP-Seq, transgenic and reporter gene experimental data that have allowed us to construct an experimentally validated regulatory network model for haematopoietic stem/progenitor cells (HSPCs). Model simulation coupled with subsequent experimental validation using single cell expression profiling revealed potential mechanisms for cell state stabilisation, and also how a leukaemogenic TF fusion protein perturbs key HSPC regulators. The approach presented here should help to improve our understanding of both normal physiological and disease processes. DOI: http://dx.doi.org/10.7554/eLife.11469.001 PMID:26901438

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

PubMed Central

Wang, Zhao; Fan, Guizhen; Hryc, Corey F; Blaza, James N; Serysheva, Irina I; Schmid, Michael F; Chiu, Wah; Luisi, Ben F; Du, Dijun

2017-01-01

Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope. Here, we report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening. Within the transport-activated state, the channel remains open even though the pump cycles through three distinct conformations. Collectively, our data provide a dynamic mechanism for the assembly and operation of the AcrAB-TolC pump. DOI: http://dx.doi.org/10.7554/eLife.24905.001 PMID:28355133

30 CFR 250.1911 - What criteria for hazards analyses must my SEMS program meet?

Code of Federal Regulations, 2012 CFR

2012-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Safety...., mobile offshore drilling units; floating production systems; floating production, storage and offloading... transportation activities for oil, gas, or sulphur from areas leased in the OCS. Facilities also include DOI...

77 FR 52340 - Meeting of the Secretarial Commission on Indian Trust Administration and Reform

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

... session the evening of September 13, 2012, at the United Tribes Technical College. DATES: The Commission's... held in the afternoon (time to be determined) on September 12, 2012, and the youth outreach session... Tribes Technical College; further information on these locations will be available at http://www.doi.gov...

Uniting functional network topology and oscillations in the fronto-parietal single unit network of behaving primates

PubMed Central

Dann, Benjamin; Michaels, Jonathan A; Schaffelhofer, Stefan; Scherberger, Hansjörg

2016-01-01

The functional communication of neurons in cortical networks underlies higher cognitive processes. Yet, little is known about the organization of the single neuron network or its relationship to the synchronization processes that are essential for its formation. Here, we show that the functional single neuron network of three fronto-parietal areas during active behavior of macaque monkeys is highly complex. The network was closely connected (small-world) and consisted of functional modules spanning these areas. Surprisingly, the importance of different neurons to the network was highly heterogeneous with a small number of neurons contributing strongly to the network function (hubs), which were in turn strongly inter-connected (rich-club). Examination of the network synchronization revealed that the identified rich-club consisted of neurons that were synchronized in the beta or low frequency range, whereas other neurons were mostly non-oscillatory synchronized. Therefore, oscillatory synchrony may be a central communication mechanism for highly organized functional spiking networks. DOI: http://dx.doi.org/10.7554/eLife.15719.001 PMID:27525488

First record of Scybalocanthon nigriceps (Harold, 1868) (Coleoptera: Scarabaeidae: Scarabaeinae) in Rio Grande do Sul state, southern Brazil.

PubMed

Ferreira, Sheila C; Mare, Rocco A DI; Silva, Pedro G DA

2017-01-01

The dung beetle, Scybalocanthon nigriceps (Harold, 1868), is recorded in Rio Grande do Sul state, Brazil, for the first time, at the Moreno Fortes Biological Reserve, municipality of Dois Irmãos das Missões, northwest region of the state, expanding the area of occurrence and distribution of this species in the country.

Breaching Pathogeographic Barriers by the Bat White-Nose Fungus.

PubMed

Rhodes, Johanna; Fisher, Matthew C

2018-05-22

Bat white-nose syndrome has become associated with unparalleled mortality in bat species across the United States since 2006. In a recent article, Drees and colleagues (mBio 8:e01941-17, 2017, https://doi.org/10.1128/mBio.01941-17) utilized both whole-genome sequencing and microsatellite data to explore the origin and spread of the causative agent of bat white-nose syndrome, Pseudogymnoascus destructans The research by Drees et al. supports the hypothesis that P. destructans was introduced into North America from Europe, with molecular dating suggesting a divergence from European isolates approximately 100 years ago. The approaches described in this study are an important contribution toward pinpointing the origins of this infection and underscore the need for more rigorous international biosecurity in order to stem the tide of emerging fungal pathogens. Copyright © 2018 Rhodes and Fisher.

Reverse total shoulder arthroplasty

PubMed Central

Familiari, Filippo; Rojas, Jorge; Nedim Doral, Mahmut; Huri, Gazi; McFarland, Edward G.

2018-01-01

Since the introduction of reverse total shoulder arthroplasty (RTSA) in 1987 (in Europe) and 2004 (in the United States), the number of RTSAs performed annually has increased. Although the main indication for RTSA has been rotator cuff tears, indications have expanded to include several shoulder conditions, many of which involve dysfunction of the rotator cuff. RTSA complications have been reported to affect 19% to 68% of patients and include acromial fracture, haematoma, infection, instability, mechanical baseplate failure, neurological injury, periprosthetic fracture and scapular notching. Current controversies in RTSA include optimal baseplate positioning, humeral neck-shaft angle (135° versus 155°), glenosphere placement (medial, lateral or bony increased offset RTSA) and subscapularis repair. Improvements in prosthesis design, surgeon experience and clinical results will need to occur to optimize this treatment for many shoulder conditions. Cite this article: EFORT Open Rev 2018;3:58–69 DOI: 10.1302/2058-5241.3.170044 PMID:29657846

STS-87 Columbia Landing at KSC

NASA Technical Reports Server (NTRS)

1997-01-01

With Commander Kevin Kregel and Pilot Steven Lindsey at the controls, the orbiter Columbia touches its main gear down on Runway 33 at KSCs Shuttle Landing Facility at 7:20:04 a.m. EST Dec. 5 to complete the 15-day, 16-hour and 34-minute-long STS-87 mission of 6.5 million miles. Also onboard the orbiter are Mission Specialists Winston Scott; Kalpana Chawla, Ph.D.; and Takao Doi, Ph.D., of the National Space Development Agency of Japan; along with Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

STS-87 Columbia landing at KSC (Drag Chute Deployed)

NASA Technical Reports Server (NTRS)

1997-01-01

With Commander Kevin Kregel and Pilot Steven Lindsey at the controls, the orbiter Columbia touches its main gear down on Runway 33 at KSCs Shuttle Landing Facility at 7:20:04 a.m. EST Dec. 5 to complete the 15-day, 16-hour and 34-minute-long STS-87 mission of 6.5 million miles. Also onboard the orbiter are Mission Specialists Winston Scott; Kalpana Chawla, Ph.D.; and Takao Doi, Ph.D., of the National Space Development Agency of Japan; along with Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

STS-87 concludes with landing of orbiter Columbia at KSC

NASA Technical Reports Server (NTRS)

1997-01-01

With Commander Kevin Kregel and Pilot Steven Lindsey at the controls, the orbiter Columbia makes a smooth touchdown on Runway 33 at KSC's Shuttle Landing Facility at 7:20:04 a.m. EST Dec. 5, completing the 15-day, 16-hour and 34-minute-long STS-87 mission of 6.5 million miles. Also onboard the orbiter are Mission Specialists Winston Scott; Kalpana Chawla, Ph.D.; and Takao Doi, Ph.D., of the National Space Development Agency of Japan; along with Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

STS 87: Meal - Suit Up - Depart O&C - Launch Columbia On Orbit - Landing - Crew Egress

NASA Technical Reports Server (NTRS)

1997-01-01

The STS-87 Space Shuttle Columbia mission begins with the introduction of the seven crew members. The seven crew members include: Commander Kevin R. Kregel, pilot Steven W. Lindsey, mission specialists: Winston E. Scott, Kalpana Chawla and Takao Doi and payload specialist Leonid K. Kadenyuk. The United States Microgravity Payload (USMP-4), Orbital Acceleration Research Experiment (OARE), the EVA Demonstration Flight Test 5 (EDFT-05), Shuttle Ozone Limb Sending Experiment (SOLSE), Loop Heat Pump (LHP), and Sodium Sulfur Battery Experiment (NaSBE) were all shown during this video presentation. The launch of the STS-87 from different Kennedy Space Flight Center (KSFC) areas and Pre-flight training at the Johnson Space Center is presented. The retrieve and recovery spot satellite are also shown. Also, the landing of the Space Shuttle Columbia is presented from different areas at Kennedy Space Flight Center.

RME 1323, AERCam/Sprint held by Lindsey in the middeck

NASA Image and Video Library

1998-01-14

STS087-371-013 (19 November - 5 December 1997) --- On the Space Shuttle Columbia's mid-deck, astronaut Steven W. Lindsey proves that the Autonomous Extravehicular Activity Robotic Camera/Sprint (AERCam/Sprint) experiment is in fact bigger than a soccer ball, to which it is often erroneously compared for dimensional frame of reference, as he allows the Sprint to float near him. The AERCam is a prototype free-flying television camera that could be used for remote inspections of the exterior of the International Space Station (ISS). Later, astronauts Winston E. Scott and Takao Doi took the experiment outside for a brief test during the mission's second Extravehicular Activity (EVA). Lindsey, pilot, is standing with his back to the galley and his left hand on the microgravity glovebox, used extensively during the mission to support the United States Microgravity Payload (USMP-4) mission.

Radio-Frequency Emissions from Streamer Collisions: Implications for High-Energy Processes.

NASA Astrophysics Data System (ADS)

Luque, A.

2017-12-01

The production of energetic particles in a discharge corona is possibly linked to the collision of streamers of opposite polarities [Cooray et al. (2009), Kochkin et al. (2012), Østgaard et al. (2016)]. There is also experimental evidence linking it to radio-frequency emissions in the UHF frequency range (300 MHz-3 GHz) [Montanyà et al. (2015), Petersen and Beasley (2014)]. Here we investigate these two links by modeling the radio-frequency emissions emanating from an encounter between two counter-propagating streamers. Our numerical model combines self-consistently a conservative, high-order Finite-Volume scheme for electron transport with a Finite-Difference Time-Domain (FDTD) method for electromagnetic propagation. We also include the most relevant reactions for streamer propagation: impact ionization, dissociative attachment and photo-ionization. Our implementation benefits from massive parallelization by running on a General-Purpose Graphical Processing Unit (GPGPU). With this code we found that streamer encounters emit electromagnetic waves predominantly in the UHF range, supporting the hypothesis that streamer collisions are essential precursors of high-energy processes in electric discharges. References Cooray, V., et al., J. Atm. Sol.-Terr. Phys., 71, 1890, doi:10.1016/j.jastp.2009.07.010 (2009). Kochkin, P. O., et al., J. Phys. D, 45, 425202, doi: 10.1088/0022-3727/45/42/425202 (2012). Montanyà, J., et al., J. Atm. Sol.-Terr. Phys., 136, 94, doi:10.1016/j.jastp.2015.06.009, (2015). Østgaard, N., et al., J. Geophys. Res. (Atmos.), 121, 2939, doi:10.1002/2015JD024394 (2016). Petersen, D., and W. Beasley, Atmospheric Research, 135, 314, doi:10.1016/j.atmosres.2013.02.006 (2014).

In Brief: Coal mining regulations

NASA Astrophysics Data System (ADS)

Showstack, Randy

2009-12-01

The U.S. Department of the Interior (DOI) announced on 18 November measures to strengthen the oversight of state surface coal mining programs and to promulgate federal regulations to protect streams affected by surface coal mining operations. DOI's Office of Surface Mining Reclamation and Enforcement (OSM) is publishing an advance notice of a proposed rule about protecting streams from adverse impacts of surface coal mining operations. A rule issued by the Bush administration in December 2008 allows coal mine operators to place excess excavated materials into streams if they can show it is not reasonably possible to avoid doing so. “We are moving as quickly as possible under the law to gather public input for a new rule, based on sound science, that will govern how companies handle fill removed from mountaintop coal seams,” according to Wilma Lewis, assistant secretary for Land and Minerals Management at DOI.

Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter

PubMed Central

Khantwal, Chandra M; Abraham, Sherwin J; Han, Wei; Jiang, Tao; Chavan, Tanmay S; Cheng, Ricky C; Elvington, Shelley M; Liu, Corey W; Mathews, Irimpan I; Stein, Richard A; Mchaourab, Hassane S; Tajkhorshid, Emad; Maduke, Merritt

2016-01-01

CLC secondary active transporters exchange Cl- for H+. Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Gluex) upon its protonation. Using 19F NMR, we show that as [H+] is increased to protonate Gluex and enrich the outward-facing state, a residue ~20 Å away from Gluex, near the subunit interface, moves from buried to solvent-exposed. Consistent with functional relevance of this motion, constriction via inter-subunit cross-linking reduces transport. Molecular dynamics simulations indicate that the cross-link dampens extracellular gate-opening motions. In support of this model, mutations that decrease steric contact between Helix N (part of the extracellular gate) and Helix P (at the subunit interface) remove the inhibitory effect of the cross-link. Together, these results demonstrate the formation of a previously uncharacterized 'outward-facing open' state, and highlight the relevance of global structural changes in CLC function. DOI: http://dx.doi.org/10.7554/eLife.11189.001 PMID:26799336

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

PubMed Central

Kroschwald, Sonja; Maharana, Shovamayee; Mateju, Daniel; Malinovska, Liliana; Nüske, Elisabeth; Poser, Ina; Richter, Doris; Alberti, Simon

2015-01-01

RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear. In this study, we analyze P bodies in budding yeast and find that they have liquid-like properties. Surprisingly, yeast stress granules adopt a different material state, which is reminiscent of solid protein aggregates and controlled by protein disaggregases. By using an assay to ectopically nucleate RNP granules, we further establish that RNP granule formation does not depend on amyloid-like aggregation but rather involves many promiscuous interactions. Finally, we show that stress granules have different properties in mammalian cells, where they show liquid-like behavior. Thus, we propose that the material state of RNP granules is flexible and that the solid state of yeast stress granules is an adaptation to extreme environments, made possible by the presence of a powerful disaggregation machine. DOI: http://dx.doi.org/10.7554/eLife.06807.001 PMID:26238190

Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

PubMed Central

Zebrowski, David C; Vergarajauregui, Silvia; Wu, Chi-Chung; Piatkowski, Tanja; Becker, Robert; Leone, Marina; Hirth, Sofia; Ricciardi, Filomena; Falk, Nathalie; Giessl, Andreas; Just, Steffen; Braun, Thomas; Weidinger, Gilbert; Engel, Felix B

2015-01-01

Mammalian cardiomyocytes become post-mitotic shortly after birth. Understanding how this occurs is highly relevant to cardiac regenerative therapy. Yet, how cardiomyocytes achieve and maintain a post-mitotic state is unknown. Here, we show that cardiomyocyte centrosome integrity is lost shortly after birth. This is coupled with relocalization of various centrosome proteins to the nuclear envelope. Consequently, postnatal cardiomyocytes are unable to undergo ciliogenesis and the nuclear envelope adopts the function as cellular microtubule organizing center. Loss of centrosome integrity is associated with, and can promote, cardiomyocyte G0/G1 cell cycle arrest suggesting that centrosome disassembly is developmentally utilized to achieve the post-mitotic state in mammalian cardiomyocytes. Adult cardiomyocytes of zebrafish and newt, which are able to proliferate, maintain centrosome integrity. Collectively, our data provide a novel mechanism underlying the post-mitotic state of mammalian cardiomyocytes as well as a potential explanation for why zebrafish and newts, but not mammals, can regenerate their heart. DOI: http://dx.doi.org/10.7554/eLife.05563.001 PMID:26247711

Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation

PubMed Central

Winans, Amy M; Collins, Sean R; Meyer, Tobias

2016-01-01

Many developing neurons transition through a multi-polar state with many competing neurites before assuming a unipolar state with one axon and multiple dendrites. Hallmarks of the multi-polar state are large fluctuations in microtubule-based transport into and outgrowth of different neurites, although what drives these fluctuations remains elusive. We show that actin waves, which stochastically migrate from the cell body towards neurite tips, direct microtubule-based transport during the multi-polar state. Our data argue for a mechanical control system whereby actin waves transiently widen the neurite shaft to allow increased microtubule polymerization to direct Kinesin-based transport and create bursts of neurite extension. Actin waves also require microtubule polymerization, arguing that positive feedback links these two components. We propose that actin waves create large stochastic fluctuations in microtubule-based transport and neurite outgrowth, promoting competition between neurites as they explore the environment until sufficient external cues can direct one to become the axon. DOI: http://dx.doi.org/10.7554/eLife.12387.001 PMID:26836307

WE-C-217BCD-10: Development of High Performance PET for Animal Imaging and Therapy Applications.

PubMed

Shao, Y; Sun, X; Lan, K; Bircher, C

2012-06-01

A prototype small animal PET is developed with several novel technologies to measure 3D gamma-interaction positions and to substantially improve imaging performance. Each new detector has an 8×8 array of 1.95×1.95×30 mm̂3 LYSO scintillators, with each end optically connected to a solid-state photo multiplier (SSPM) array through a light guide. This dual-ended-readout enables the depth-of-interaction (DOI) measurement. Each SSPM array has 16 SSPMs arranged in a 4×4 matrix. Each SSPM has active area about 3×3 mm̂2, with its output read by an ASIC electronics that directly converts analog signals to digital timing pulses which encode the interaction information for energy, timing, crystal of interaction, and DOI calculations. These digital pulses are transferred to and decoded by FPGA-based TDC for coincident event selection and data acquisition. This independent readout of each SSPM and parallel signal process significantly improve signal-to-noise ratio and permit applying flexible data processing algorithms. The current prototype system consists of two rotating detector panels on a portable gantry, with 4 detectors linearly packed together in each panel to provide ∼16 mm axial and variable trans- axial FOV with adjustable panel-to-panel distance. List-mode OSEM-based image reconstruction with resolution modeling was implemented. Both Na- 22 point source and phantom were used to evaluate the system performance. The measured energy, timing, spatial and DOI resolutions for each crystal were around 16%, 2.6 ns, 2.0 mm and 5.0 mm, respectively. The measured spatial resolutions with DOI were ∼1.7 mm across the entire FOV in all direction, while those without DOI were much worse and non-uniform across the FOV, in the range predominately around 3.0 to 4.0 mm. In addition, images from a F-18 hot-rod phantom with DOI show significantly improved quality compared to those without DOI. DOI- measurable PET shows substantially improved image performance for a compact system. National Institute of Health. University of Texas MD Anderson Cancer Center. © 2012 American Association of Physicists in Medicine.

Particulate Matter Exposure and Preterm Birth: Estimates of U.S. Attributable Burden and Economic Costs

PubMed Central

Trasande, Leonardo; Malecha, Patrick; Attina, Teresa M.

2016-01-01

Background: Preterm birth (PTB) rates (11.4% in 2013) in the United States remain high and are a substantial cause of morbidity. Studies of prenatal exposure have associated particulate matter ≤ 2.5 μm in diameter (PM2.5) and other ambient air pollutants with adverse birth outcomes; yet, to our knowledge, burden and costs of PM2.5-attributable PTB have not been estimated in the United States. Objectives: We aimed to estimate burden of PTB in the United States and economic costs attributable to PM2.5 exposure in 2010. Methods: Annual deciles of PM2.5 were obtained from the U.S. Environmental Protection Agency. We converted PTB odds ratio (OR), identified in a previous meta-analysis (1.15 per 10 μg/m3 for our base case, 1.07–1.16 for low- and high-end scenarios) to relative risk (RRs), to obtain an estimate that better represents the true relative risk. A reference level (RL) of 8.8 μg/m3 was applied. We then used the RR estimates and county-level PTB prevalence to quantify PM2.5-attributable PTB. Direct medical costs were obtained from the 2007 Institute of Medicine report, and lost economic productivity (LEP) was estimated using a meta-analysis of PTB-associated IQ loss, and well-established relationships of IQ loss with LEP. All costs were calculated using 2010 dollars. Results: An estimated 3.32% of PTBs nationally (corresponding to 15,808 PTBs) in 2010 could be attributed to PM2.5 (PM2.5 > 8.8 μg/m3). Attributable PTBs cost were estimated at $5.09 billion [sensitivity analysis (SA): $2.43–9.66 B], of which $760 million were spent for medical care (SA: $362 M–1.44 B). The estimated PM2.5 attributable fraction (AF) of PTB was highest in urban counties, with highest AFs in the Ohio Valley and the southern United States. Conclusions: PM2.5 may contribute substantially to burden and costs of PTB in the United States, and considerable health and economic benefits could be achieved through environmental regulatory interventions that reduce PM2.5 exposure in pregnancy. Citation: Trasande L, Malecha P, Attina TM. 2016. Particulate matter exposure and preterm birth: estimates of U.S. attributable burden and economic costs. Environ Health Perspect 124:1913–1918; http://dx.doi.org/10.1289/ehp.1510810 PMID:27022947

Particulate Matter Exposure and Preterm Birth: Estimates of U.S. Attributable Burden and Economic Costs.

PubMed

Trasande, Leonardo; Malecha, Patrick; Attina, Teresa M

2016-12-01

Preterm birth (PTB) rates (11.4% in 2013) in the United States remain high and are a substantial cause of morbidity. Studies of prenatal exposure have associated particulate matter ≤ 2.5 μm in diameter (PM2.5) and other ambient air pollutants with adverse birth outcomes; yet, to our knowledge, burden and costs of PM2.5-attributable PTB have not been estimated in the United States. We aimed to estimate burden of PTB in the United States and economic costs attributable to PM2.5 exposure in 2010. Annual deciles of PM2.5 were obtained from the U.S. Environmental Protection Agency. We converted PTB odds ratio (OR), identified in a previous meta-analysis (1.15 per 10 μg/m3 for our base case, 1.07-1.16 for low- and high-end scenarios) to relative risk (RRs), to obtain an estimate that better represents the true relative risk. A reference level (RL) of 8.8 μg/m3 was applied. We then used the RR estimates and county-level PTB prevalence to quantify PM2.5-attributable PTB. Direct medical costs were obtained from the 2007 Institute of Medicine report, and lost economic productivity (LEP) was estimated using a meta-analysis of PTB-associated IQ loss, and well-established relationships of IQ loss with LEP. All costs were calculated using 2010 dollars. An estimated 3.32% of PTBs nationally (corresponding to 15,808 PTBs) in 2010 could be attributed to PM2.5 (PM2.5 > 8.8 μg/m3). Attributable PTBs cost were estimated at $5.09 billion [sensitivity analysis (SA): $2.43-9.66 B], of which $760 million were spent for medical care (SA: $362 M-1.44 B). The estimated PM2.5 attributable fraction (AF) of PTB was highest in urban counties, with highest AFs in the Ohio Valley and the southern United States. PM2.5 may contribute substantially to burden and costs of PTB in the United States, and considerable health and economic benefits could be achieved through environmental regulatory interventions that reduce PM2.5 exposure in pregnancy. Citation: Trasande L, Malecha P, Attina TM. 2016. Particulate matter exposure and preterm birth: estimates of U.S. attributable burden and economic costs. Environ Health Perspect 124:1913-1918; http://dx.doi.org/10.1289/ehp.1510810.

Spatially coordinated dynamic gene transcription in living pituitary tissue

PubMed Central

Featherstone, Karen; Hey, Kirsty; Momiji, Hiroshi; McNamara, Anne V; Patist, Amanda L; Woodburn, Joanna; Spiller, David G; Christian, Helen C; McNeilly, Alan S; Mullins, John J; Finkenstädt, Bärbel F; Rand, David A; White, Michael RH; Davis, Julian RE

2016-01-01

Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over time, as opposed to studying snap-shots of gene expression state. We have used imaging of reporter gene expression to track transcription in living pituitary tissue. We integrated live-cell imaging data with statistical modelling for quantitative real-time estimation of the timing of switching between transcriptional states across a whole tissue. Multiple levels of transcription rate were identified, indicating that gene expression is not a simple binary ‘on-off’ process. Immature tissue displayed shorter durations of high-expressing states than the adult. In adult pituitary tissue, direct cell contacts involving gap junctions allowed local spatial coordination of prolactin gene expression. Our findings identify how heterogeneous transcriptional dynamics of single cells may contribute to overall tissue behaviour. DOI: http://dx.doi.org/10.7554/eLife.08494.001 PMID:26828110

Tracking transcription factor mobility and interaction in Arabidopsis roots with fluorescence correlation spectroscopy

PubMed Central

Clark, Natalie M; Hinde, Elizabeth; Winter, Cara M; Fisher, Adam P; Crosti, Giuseppe; Blilou, Ikram; Gratton, Enrico; Benfey, Philip N; Sozzani, Rosangela

2016-01-01

To understand complex regulatory processes in multicellular organisms, it is critical to be able to quantitatively analyze protein movement and protein-protein interactions in time and space. During Arabidopsis development, the intercellular movement of SHORTROOT (SHR) and subsequent interaction with its downstream target SCARECROW (SCR) control root patterning and cell fate specification. However, quantitative information about the spatio-temporal dynamics of SHR movement and SHR-SCR interaction is currently unavailable. Here, we quantify parameters including SHR mobility, oligomeric state, and association with SCR using a combination of Fluorescent Correlation Spectroscopy (FCS) techniques. We then incorporate these parameters into a mathematical model of SHR and SCR, which shows that SHR reaches a steady state in minutes, while SCR and the SHR-SCR complex reach a steady-state between 18 and 24 hr. Our model reveals the timing of SHR and SCR dynamics and allows us to understand how protein movement and protein-protein stoichiometry contribute to development. DOI: http://dx.doi.org/10.7554/eLife.14770.001 PMID:27288545

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

PubMed Central

Sasaki, Yo; Nakagawa, Takashi; Mao, Xianrong; DiAntonio, Aaron; Milbrandt, Jeffrey

2016-01-01

Overexpression of the NAD+ biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD+ or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD+ metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD+ synthesis, NMNAT1 instead blocks the injury-induced, SARM1-dependent NAD+ consumption that is central to axon degeneration. DOI: http://dx.doi.org/10.7554/eLife.19749.001 PMID:27735788

43 CFR Appendix B to Part 2 - Internet Addresses

Code of Federal Regulations, 2010 CFR

2010-10-01

... Page: http://www.doi.gov 2. DOI FOIA Home Page: http://www.doi.gov/foia/ 3. DOI Reference Guide for Obtaining Information: http://www.doi.gov/foia/foitabl.htm 4. List of DOI Public Affairs Offices: http://www.doi.gov/foia/list.html 5. DOI FOIA Contacts: http://www.doi.gov/foia/contacts.html 6. DOI FOIA...

43 CFR Appendix B to Part 2 - Internet Addresses

Code of Federal Regulations, 2012 CFR

2012-10-01

... Page: http://www.doi.gov 2. DOI FOIA Home Page: http://www.doi.gov/foia/ 3. DOI Reference Guide for Obtaining Information: http://www.doi.gov/foia/foitabl.htm 4. List of DOI Public Affairs Offices: http://www.doi.gov/foia/list.html 5. DOI FOIA Contacts: http://www.doi.gov/foia/contacts.html 6. DOI FOIA...

Travelling-wave amplitudes as solutions of the phase-field crystal equation

NASA Astrophysics Data System (ADS)

Nizovtseva, I. G.; Galenko, P. K.

2018-01-01

The dynamics of the diffuse interface between liquid and solid states is analysed. The diffuse interface is considered as an envelope of atomic density amplitudes as predicted by the phase-field crystal model (Elder et al. 2004 Phys. Rev. E 70, 051605 (doi:10.1103/PhysRevE.70.051605); Elder et al. 2007 Phys. Rev. B 75, 064107 (doi:10.1103/PhysRevB.75.064107)). The propagation of crystalline amplitudes into metastable liquid is described by the hyperbolic equation of an extended Allen-Cahn type (Galenko & Jou 2005 Phys. Rev. E 71, 046125 (doi:10.1103/PhysRevE.71.046125)) for which the complete set of analytical travelling-wave solutions is obtained by the method (Malfliet & Hereman 1996 Phys. Scr. 15, 563-568 (doi:10.1088/0031-8949/54/6/003); Wazwaz 2004 Appl. Math. Comput. 154, 713-723 (doi:10.1016/S0096-3003(03)00745-8)). The general solution of travelling waves is based on the function of hyperbolic tangent. Together with its set of particular solutions, the general solution is analysed within an example of specific task about the crystal front invading metastable liquid (Galenko et al. 2015 Phys. D 308, 1-10 (doi:10.1016/j.physd.2015.06.002)). The influence of the driving force on the phase-field profile, amplitude velocity and correlation length is investigated for various relaxation times of the gradient flow. This article is part of the theme issue `From atomistic interfaces to dendritic patterns'.

The integrated water balance and soil data set of the Rollesbroich hydrological observatory

NASA Astrophysics Data System (ADS)

Qu, Wei; Bogena, Heye R.; Huisman, Johan A.; Schmidt, Marius; Kunkel, Ralf; Weuthen, Ansgar; Schiedung, Henning; Schilling, Bernd; Sorg, Jürgen; Vereecken, Harry

2016-10-01

The Rollesbroich headwater catchment located in western Germany is a densely instrumented hydrological observatory and part of the TERENO (Terrestrial Environmental Observatories) initiative. The measurements acquired in this observatory present a comprehensive data set that contains key hydrological fluxes in addition to important hydrological states and properties. Meteorological data (i.e., precipitation, air temperature, air humidity, radiation components, and wind speed) are continuously recorded and actual evapotranspiration is measured using the eddy covariance technique. Runoff is measured at the catchment outlet with a gauging station. In addition, spatiotemporal variations in soil water content and temperature are measured at high resolution with a wireless sensor network (SoilNet). Soil physical properties were determined using standard laboratory procedures from samples taken at a large number of locations in the catchment. This comprehensive data set can be used to validate remote sensing retrievals and hydrological models, to improve the understanding of spatial temporal dynamics of soil water content, to optimize data assimilation and inverse techniques for hydrological models, and to develop upscaling and downscaling procedures of soil water content information. The complete data set is freely available online (http://www.tereno.net, doi:10.5880/TERENO.2016.001, doi:10.5880/TERENO.2016.004, doi:10.5880/TERENO.2016.003) and additionally referenced by three persistent identifiers securing the long-term data and metadata availability.

Phenotypic states become increasingly sensitive to perturbations near a bifurcation in a synthetic gene network

PubMed Central

Axelrod, Kevin; Sanchez, Alvaro; Gore, Jeff

2015-01-01

Microorganisms often exhibit a history-dependent phenotypic response after exposure to a stimulus which can be imperative for proper function. However, cells frequently experience unexpected environmental perturbations that might induce phenotypic switching. How cells maintain phenotypic states in the face of environmental fluctuations remains an open question. Here, we use environmental perturbations to characterize the resilience of phenotypic states in a synthetic gene network near a critical transition. We find that far from the critical transition an environmental perturbation may induce little to no phenotypic switching, whereas close to the critical transition the same perturbation can cause many cells to switch phenotypic states. This loss of resilience was observed for perturbations that interact directly with the gene circuit as well as for a variety of generic perturbations-such as salt, ethanol, or temperature shocks-that alter the state of the cell more broadly. We obtain qualitatively similar findings in natural gene circuits, such as the yeast GAL network. Our findings illustrate how phenotypic memory can become destabilized by environmental variability near a critical transition. DOI: http://dx.doi.org/10.7554/eLife.07935.001 PMID:26302311

Watershed health assessment to monitor land degradation

NASA Astrophysics Data System (ADS)

Hamidreza Sadeghi, Seyed; Hazbavi, Zeinab; Cerdà, Artemi

2017-04-01

Land degradation is a worldwide issue that affects the Planet and the fate of the humankind (Cerdà et al., 2009; Choudhury et al., 2016; Fernández et al., 2016; Ferreira et al., 2016). Several processes affect the sustainability of the ecosystems, from soil erosion to soil compation, deforestation, Climate Change or water, soil and air pollution (Sadeghi et al., 2015a; 2015b; Gómez-Acanta et al., 2016; Mengistu et al., 2016; Mukai, 2016). Several ecosystem theories have been presented in the scientific literatures to monitor land degradation (Cerdà et al., 2016; Davudirad et al., 2016; Fava et al., 2016; Mahyou et al., 2016; Soulard et al., 2016). Besides the scientific tasks of improving the indication, the conviction of the potential users to change their concepts toward a higher consideration of ecosystem attributes, and toward a fruitful application of the health or integrity concepts, will be a main task of future activities. Reliability, resilience and vulnerability (R-R-V) indicators are often used in combination for quantifying risk and decision making in many systems. However, the use of hydrological series data for R-R-V computations has been rather limited. Toward this, the overall objective of this paper is to conduct a risk assessment analysis on stream flow discharge from Shazand Watershed located in the south western of Markazi Province in Iran for the period of 1972-2014 using R-R-V indicators. Based on the R-R-V analysis conducted in this study, the stream flow discharge of the study region followed a cyclic pattern with a decreasing trend. The results further showed a decreasing trend in reliability and resilience and an increasing trend in vulnerability in the Shazand Watershed. It may be concluded that the Shazand Watershed was in overall in unhealthy condition from view of stream flow discharge. Acknowledgements This research was funded by the European Union Seventh Framework Programme (FP7/2007-2013) under grant no. 603498 (RECARE Project). References Cerdà, A., A. G. Morera, and M. B. Bodí. 2009. Soil and Water Losses from New Citrus Orchards Growing on Sloped Soils in the Western Mediterranean Basin. Earth Surface Processes and Landforms 34 (13): 1822-1830. doi:10.1002/esp.1889. Cerdà, A., González-Pelayo, O., Giménez-Morera, A., Jordán, A., Pereira, P., Novara, A., Brevik, E.C., Prosdocimi, M., Mahmoodabadi, M., Keesstra, S., García Orenes, F., Ritsema, C., 2016. The use of barley straw residues to avoid high erosion and runoff rates on persimmon plantations in Eastern Spain under low frequency - high magnitude simulated rainfall events. Soil Res, 54, 2, 154-165 DOI: 10.1071/SR15092 Choudhury, B. U., A. R. Fiyaz, K. P. Mohapatra, and S. Ngachan. 2016. Impact of Land Uses, Agrophysical Variables and Altitudinal Gradient on Soil Organic Carbon Concentration of North-Eastern Himalayan Region of India. Land Degradation and Development 27 (4): 1163-1174. doi:10.1002/ldr.2338. Davudirad, A. A., S. H. Sadeghi, and A. Sadoddin. 2016. The Impact of Development Plans on Hydrological Changes in the Shazand Watershed, Iran. Land Degradation and Development 27 (4): 1236-1244. doi:10.1002/ldr.2523. Fava, F., G. Pulighe, and A. T. Monteiro. 2016. Mapping Changes in Land Cover Composition and Pattern for Comparing Mediterranean Rangeland Restoration Alternatives. Land Degradation and Development 27 (3): 671-681. doi:10.1002/ldr.2456. Fernández-Romero, M. L., B. Lozano-García, L. Parras-Alcántara, C. D. Collins, and J. M. Clark. 2016. Effects of Land Management on Different Forms of Soil Carbon in Olive Groves in Mediterranean Areas. Land Degradation and Development 27 (4): 1186-1195. doi:10.1002/ldr.2327. Ferreira, A. C. C., L. F. C. Leite, A. S. F. de Araújo, and N. Eisenhauer. 2016. Land-use Type Effects on Soil Organic Carbon and Microbial Properties in a Semi-Arid Region of Northeast Brazil. Land Degradation and Development 27 (2): 171-178. doi:10.1002/ldr.2282. Gómez-Acata, E. S., I. Valencia-Becerril, C. Valenzuela-Encinas, A. S. Velásquez-Rodríguez, Y. E. Navarro-Noya, N. Montoya-Ciriaco, M. C. Suárez-Arriaga, et al. 2016. Deforestation and Cultivation with Maize (Zea Mays L.) has a Profound Effect on the Bacterial Community Structure in Soil. Land Degradation and Development 27 (4): 1122-1130. doi:10.1002/ldr.2328. Mahyou, H., B. Tychon, R. Balaghi, M. Louhaichi, and J. Mimouni. 2016. A Knowledge-Based Approach for Mapping Land Degradation in the Arid Rangelands of North Africa. Land Degradation and Development. doi:10.1002/ldr.2470. Mengistu, D., W. Bewket, and R. Lal. 2016. Conservation Effects on Soil Quality and Climate Change Adaptability of Ethiopian Watersheds. Land Degradation and Development 27 (6): 1603-1621. doi:10.1002/ldr.2376. Mukai, S. 2016. Gully Erosion Rates and Analysis of Determining Factors: A Case Study from the Semi-Arid Main Ethiopian Rift Valley. Land Degradation and Development. doi:10.1002/ldr.2532. Sadeghi, S.H.R., Gholami, L., Homaee, M., Khaledi Darvishan, A. 2015. Reducing sediment concentration and soil loss using organic and inorganic amendments at plot scale. Solid Earth, 6 (2), pp. 445-455. DOI: http://dx.doi.org/10.5194/se-6-445-2015 Sadeghi, S.H.R., Gholami, L., Sharifi, E., Khaledi Darvishan, A., Homaee, M. 2015. Scale effect on runoff and soil loss control using rice straw mulch under laboratory conditions. Solid Earth, 6 (1), pp. 1-8.. DOI: http://dx.doi.org/10.5194/se-6-1-2015 Soulard, C. E., W. Acevedo, S. V. Stehman, and O. P. Parker. 2016. Mapping Extent and Change in Surface Mines within the United States for 2001 to 2006. Land Degradation and Development 27 (2): 248-257. doi:10.1002/ldr.2412.

Clonal Dissemination of Enterobacter cloacae Harboring blaKPC-3 in the Upper Midwestern United States

PubMed Central

Hargreaves, Melissa L.; Shaw, Kristin M.; Dobbins, Ginette; Snippes Vagnone, Paula M.; Harper, Jane E.; Boxrud, Dave; Lynfield, Ruth; Aziz, Maliha; Price, Lance B.; Silverstein, Kevin A. T.; Danzeisen, Jessica L.; Youmans, Bonnie; Case, Kyle; Sreevatsan, Srinand

2015-01-01

Carbapenemase-producing, carbapenem-resistant Enterobacteriaceae, or CP-CRE, are an emerging threat to human and animal health, because they are resistant to many of the last-line antimicrobials available for disease treatment. Carbapenemase-producing Enterobacter cloacae harboring blaKPC-3 recently was reported in the upper midwestern United States and implicated in a hospital outbreak in Fargo, North Dakota (L. M. Kiedrowski, D. M. Guerrero, F. Perez, R. A. Viau, L. J. Rojas, M. F. Mojica, S. D. Rudin, A. M. Hujer, S. H. Marshall, and R. A. Bonomo, Emerg Infect Dis 20:1583–1585, 2014, http://dx.doi.org/10.3201/eid2009.140344). In early 2009, the Minnesota Department of Health began collecting and screening CP-CRE from patients throughout Minnesota. Here, we analyzed a retrospective group of CP-E. cloacae isolates (n = 34) collected between 2009 and 2013. Whole-genome sequencing and analysis revealed that 32 of the strains were clonal, belonging to the ST171 clonal complex and differing collectively by 211 single-nucleotide polymorphisms, and it revealed a dynamic clone under positive selection. The phylogeography of these strains suggests that this clone existed in eastern North Dakota and western Minnesota prior to 2009 and subsequently was identified in the Minneapolis and St. Paul metropolitan area. All strains harbored identical IncFIA-like plasmids conferring a CP-CRE phenotype and an additional IncX3 plasmid. In a single patient with multiple isolates submitted over several months, we found evidence that these plasmids had transferred from the E. cloacae clone to an Escherichia coli ST131 bacterium, rendering it as a CP-CRE. The spread of this clone throughout the upper midwestern United States is unprecedented for E. cloacae and highlights the importance of continued surveillance to identify such threats to human health. PMID:26438492

Heat, Heat Waves, and Hospital Admissions among the Elderly in the United States, 1992–2006

PubMed Central

Zanobetti, Antonella; Schwartz, Joel D.; Wellenius, Gregory A.; O’Neill, Marie S.

2014-01-01

Background: Heat-wave frequency, intensity, and duration are increasing with global climate change. The association between heat and mortality in the elderly is well documented, but less is known regarding associations with hospital admissions. Objectives: Our goal was to determine associations between moderate and extreme heat, heat waves, and hospital admissions for nonaccidental causes among Medicare beneficiaries ≥ 65 years of age in 114 cities across five U.S. climate zones. Methods: We used Medicare inpatient billing records and city-specific data on temperature, humidity, and ozone from 1992 through 2006 in a time-stratified case-crossover design to estimate the association between hospitalization and moderate [90th percentile of apparent temperature (AT)] and extreme (99th percentile of AT) heat and heat waves (AT above the 95th percentile over 2–8 days). In sensitivity analyses, we additionally considered confounding by ozone and holidays, different temperature metrics, and alternate models of the exposure–response relationship. Results: Associations between moderate heat and hospital admissions were minimal, but extreme heat was associated with a 3% (95% CI: 2%, 4%) increase in all-cause hospital admissions over the subsequent 8 days. In cause-specific analyses, extreme heat was associated with increased hospitalizations for renal (15%; 95% CI: 9%, 21%) and respiratory (4%; 95% CI: 2%, 7%) diseases, but not for cardiovascular diseases. An added heat-wave effect was observed for renal and respiratory admissions. Conclusion: Extreme heat is associated with increased hospital admissions, particularly for renal causes, among the elderly in the United States. Citation: Gronlund CJ, Zanobetti A, Schwartz JD, Wellenius GA, O’Neill MS. 2014. Heat, heat waves, and hospital admissions among the elderly in the United States, 1992–2006. Environ Health Perspect 122:1187–1192; http://dx.doi.org/10.1289/ehp.1206132 PMID:24905551

a View of the Marble-Cake Mantle from the Southeast Indian Ridge

NASA Astrophysics Data System (ADS)

Hanan, B. B.; Graham, D. W.; Hemond, C.; Blichert-Toft, J.; Albarede, F.

2014-12-01

Along the Southeast Indian Ridge, variations in axial depth, crustal thickness, hydrothermal venting [1], basaltic major elements and U-series disequilibria [2] all indicate a west-to-east decrease in magma supply and mantle temperature from the Amsterdam-St. Paul hotspot to the Australian-Antarctic Discordance. Paired Hf-Pb isotopes in closely spaced glasses (5-10 km) from 81-100°E define two populations revealing compositional streaks in the upper mantle [3]. The number density of the streaks follows a Poisson distribution with a characteristic thickness of ~20 km. K/Ti and Na8 do not correlate with Pb or Hf isotopes, and both isotopic domains encompass N- and E-MORB types indicating the variations represent mantle source heterogeneities. 3He/4He varies from 7.5 - 10.2 RA, more than half the range in global MORB away from hotspot influence [4]. No systematic relationship exists between 3He/4He and Pb or Hf isotopes. A general negative correlation between K/Ti and Fe8 for the SEIR resembles that for MORBs globally, with higher K/Ti associated with lower 3He/4He. Collectively the observations suggest the presence of lithologically heterogeneous mantle. Lower 3He/4He derives from a source containing a few percent pyroxenite or ecologite, while 3He/4He > 9 RA arises from peridotite. Mantle convection has folded together distinct composite reservoirs of heterogeneous mantle, and stretched them into streaks that remain discernible units. The mantle 'unit' giving rise to each MORB sample represents a 'mixture of mixtures' with a multi-stage mixing history. Spectral analysis of the length scales of Hf, Pb and He isotopic variability allows a visual representation of this upper mantle 'texture'. The dominant length scales reflect large (1000, 500 km) and regional scale (100-150 km) structures in mantle flow, and sampling of heterogeneities during partial melting (20-30 km). 1-Baker et al., doi:10.1002/2014GC005344; 2-Russo et al., doi:10.1016/j.epsl.2008.11.016; 3-Hanan et al., doi:10.1016/j.epsl.2013.05.028; 4-Graham et al., doi:10.1002/2014GC005264

Seismic observation of a sharp post-garnet phase transition within the Farallon crust: Evidence for oceanic plateau subduction

NASA Astrophysics Data System (ADS)

Maguire, R.; Ritsema, J.

2017-12-01

The tectonic evolution of North America over the past 150 million years was heavily influenced by the complex subduction history of the Farallon plate. In particular, Laramide mountain building may have been triggered by the initiation of flat slab subduction in the late Cretaceous. While it has been proposed that the cause of slab flattening is related to the subduction of an oceanic plateau[1], direct geophysical evidence of a subducted oceanic plateau is lacking. Here, using P-to-S receiver functions, we detect a sharp seismic discontinuity at 720-km depth beneath the southeastern United States and Gulf of Mexico. We interpret this discontinuity as a garnet-to-bridgmanite phase transition occurring within a thickened Farallon crust. Our results are consistent with a subducted oceanic plateau (likely the conjugate half of the Hess rise) which is foundering below the base of the mantle transition zone. Additionally, we find a strong 520-km discontinuity beneath the southeastern United States which may indicate a hydrous transition zone due to the release of H2O from the Farallon slab. These results provide insight into the dynamics of flat slab subduction as well as the tectonic history of North America. [1] Livaccari, R. F., Burke, K., & Şengör, A. M. C. (1981). Was the Laramide orogeny related to subduction of an oceanic plateau? Nature, v. 289, p. 276-278, doi: 10.1038/289276a0

Environmental Noise Pollution in the United States: Developing an Effective Public Health Response

PubMed Central

Hammer, Monica S.; Swinburn, Tracy K.

2013-01-01

Background: Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise pollution. Objectives: We aimed to describe some of the most serious health effects associated with noise, summarize exposures from several highly prevalent noise sources based on published estimates as well as extrapolations made using these estimates, and lay out proven mechanisms and strategies to reduce noise by incorporating scientific insight and technological innovations into existing public health infrastructure. Discussion: We estimated that 104 million individuals had annual LEQ(24) levels > 70 dBA (equivalent to a continuous average exposure level of >70 dBA over 24 hr) in 2013 and were at risk of noise-induced hearing loss. Tens of millions more may be at risk of heart disease, and other noise-related health effects. Direct regulation, altering the informational environment, and altering the built environment are the least costly, most logistically feasible, and most effective noise reduction interventions. Conclusion: Significant public health benefit can be achieved by integrating interventions that reduce environmental noise levels and exposures into the federal public health agenda. Citation: Hammer MS, Swinburn TK, Neitzel RL. 2014. Environmental noise pollution in the United States: developing an effective public health response. Environ Health Perspect 122:115–119; http://dx.doi.org/10.1289/ehp.1307272 PMID:24311120

Reference Levels for Patient Radiation Doses in Interventional Radiology: Proposed Initial Values for U.S. Practice1

PubMed Central

Miller, Donald L.; Kwon, Deukwoo; Bonavia, Grant H.

2009-01-01

Purpose: To propose initial values for patient reference levels for fluoroscopically guided procedures in the United States. Materials and Methods: This secondary analysis of data from the Radiation Doses in Interventional Radiology Procedures (RAD-IR) study was conducted under a protocol approved by the institutional review board and was HIPAA compliant. Dose distributions (percentiles) were calculated for each type of procedure in the RAD-IR study where there were data from at least 30 cases. Confidence intervals for the dose distributions were determined by using bootstrap resampling. Weight banding and size correction methods for normalizing dose to patient body habitus were tested. Results: The different methods for normalizing patient radiation dose according to patient weight gave results that were not significantly different (P > .05). The 75th percentile patient radiation doses normalized with weight banding were not significantly different from those that were uncorrected for body habitus. Proposed initial reference levels for various interventional procedures are provided for reference air kerma, kerma-area product, fluoroscopy time, and number of images. Conclusion: Sufficient data exist to permit an initial proposal of values for reference levels for interventional radiologic procedures in the United States. For ease of use, reference levels without correction for body habitus are recommended. A national registry of radiation-dose data for interventional radiologic procedures is a necessary next step to refine these reference levels. © RSNA, 2009 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2533090354/-/DC1 PMID:19789226

Genetic and epigenetic variation in the lineage specification of regulatory T cells

PubMed Central

Arvey, Aaron; van der Veeken, Joris; Plitas, George; Rich, Stephen S; Concannon, Patrick; Rudensky, Alexander Y

2015-01-01

Regulatory T (Treg) cells, which suppress autoimmunity and other inflammatory states, are characterized by a distinct set of genetic elements controlling their gene expression. However, the extent of genetic and associated epigenetic variation in the Treg cell lineage and its possible relation to disease states in humans remain unknown. We explored evolutionary conservation of regulatory elements and natural human inter-individual epigenetic variation in Treg cells to identify the core transcriptional control program of lineage specification. Analysis of single nucleotide polymorphisms in core lineage-specific enhancers revealed disease associations, which were further corroborated by high-resolution genotyping to fine map causal polymorphisms in lineage-specific enhancers. Our findings suggest that a small set of regulatory elements specify the Treg lineage and that genetic variation in Treg cell-specific enhancers may alter Treg cell function contributing to polygenic disease. DOI: http://dx.doi.org/10.7554/eLife.07571.001 PMID:26510014

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

PubMed Central

Covarrubias, Anthony J; Aksoylar, Halil Ibrahim; Yu, Jiujiu; Snyder, Nathaniel W; Worth, Andrew J; Iyer, Shankar S; Wang, Jiawei; Ben-Sahra, Issam; Byles, Vanessa; Polynne-Stapornkul, Tiffany; Espinosa, Erika C; Lamming, Dudley; Manning, Brendan D; Zhang, Yijing; Blair, Ian A; Horng, Tiffany

2016-01-01

Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in Ac-CoA synthesis, leading to increased histone acetylation and M2 gene induction. Only a subset of M2 genes is controlled in this way, including those regulating cellular proliferation and chemokine production. Moreover, metabolic signals impinge on the Akt-mTORC1 axis for such control of M2 activation. We propose that Akt-mTORC1 signaling calibrates metabolic state to energetically demanding aspects of M2 activation, which may define a new role for metabolism in supporting macrophage activation. DOI: http://dx.doi.org/10.7554/eLife.11612.001 PMID:26894960

The Department of the Interior Southeast Climate Science Center synthesis report 2011–15—Projects, products, and science priorities

USGS Publications Warehouse

Varela Minder, Elda; Lascurain, Aranzazu R.; McMahon, Gerard

2016-09-28

IntroductionIn 2009, the U.S. Department of the Interior (DOI) Secretary Ken Salazar established a network of eight regional Climate Science Centers (CSCs) that, along with the Landscape Conservation Cooperatives (LCCs), would help define and implement the Department's climate adaptation response. The Southeast Climate Science Center (SE CSC) was established at North Carolina State University (NCSU) in Raleigh, North Carolina, in 2010, under a 5-year cooperative agreement with the U.S. Geological Survey (USGS), to identify and address the regional challenges presented by climate change and variability in the Southeastern United States. All eight regional CSC hosts, including NCSU, were selected through a competitive process.Since its opening, the focus of the SE CSC has been on working with partners in the identification and development of research-based information that can assist managers, including cultural and natural resource managers, in adapting to global change processes, such as climate and land use change, that operate at local to global scales and affect resources important to the DOI mission. The SE CSC was organized to accomplish three goals:Provide co-produced, researched based, actionable science that supports transparent global change adaptation decisions.Convene conversations among decision makers, scientists, and managers to identify key ecosystem adaptation decisions driven by climate and land use change, the values and objectives that will be used to make decisions, and the research-based information needed to assess adaptation options.Build the capacity of natural resource professionals, university faculty, and students to understand and frame natural resource adaptation decisions and develop and use research-based information to make adaptation decisions.This report provides an overview of the SE CSC and the projects developed by the SE CSC since its inception. An important goal of this report is to provide a framework for understanding the evolution of the SE CSC science agenda, which has evolved over the first 5 years of the Center’s operation.

White light emission from an exciplex interface with a single emitting layer (Conference Presentation)

NASA Astrophysics Data System (ADS)

Bernal, Wilson; Perez-Gutierrez, Enrique; Agular, Andres; Barbosa G, J. Oracio C.; Maldonado, Jose L.; Meneses-Nava, Marco Antonio; Rodriguez Rivera, Mario A.; Rodriguez, Braulio

2017-02-01

Efficient solid state lighting devices based in inorganic emissive materials are now available in the market meanwhile for organic emissive materials still a lot of research work is in its way. [1,2] In this work a new organic emissive material based on carbazole, N-(4-Ethynylphenyl) carba-zole-d4 (6-d4), is used as electron-acceptor and commercial PEDOT:PSS as the electron-donor to obtain white emission. Besides the HOMO-LUMO levels of materials the white emission showed dependence on the films thicknesses and applied voltages. In here it is reported that by diminishing the thickness of the PEDOT:PSS layer, from 60 to 35 nm, and by keeping the derivative carbazole layer constant at 100 nm the electro-luminescence (EL) changed from emissive exciton states to the mixture of emissive exciton and exciplex states. [3] For the former thicknesses no white light was obtained meanwhile for the later the EL spectra broadened due to the emission of exciplex states. Under this condition, the best-achieved CIE coordinate was (0.31,0.33) with a driving voltage of 8 V. To lower the driving voltage of the devices a thin film of LiF was added between the derivative of carbazol and cathode but the CIE coordinates changed. The best CIE coordinates for this case were (0.29, 0.34) and (0.32, 0.37) with driving voltage of about 6.5 V. Acknowledgments: CeMie-Sol/27 (Mexico) 207450 References [1] Timothy L Dawson, Society of Dyers and Colourists, Color. Technol., 126, 1-10 (2010), doi: 10.1111/j.1478-4408.2010.00220.x [2] G. M. Farinola, R. Ragni, Journal of Solid State Lighting, 2:9 (2015), doi: 10.1186/s40539-015-0028-7. [3] E. Angioni, et al, J. Mater. Chem. C, 2016, 4, 3851, doi: 10.1039/c6tc00750c.

Cannabinoids: clearing the smoke on pain, inflammation and neurodegeneration.

PubMed

Downer, E J; Finn, D P

2014-03-01

This article is part of a themed section on Cannabinoids 2013. To view the other articles in this section, see Fagan and Campbell (2014) DOI: 10.1111/bph.12492, Ignatowska-Jankowska et al. (2014) DOI: 10.1111/bph.12298, Ligresti et al. (2014) DOI: 10.1111/bph.12410, Lopez-Rodriguez et al. (2014) DOI: 10.1111/bph.12519, Murataeva et al. (2014) DOI: 10.1111/bph.12411, Okine et al. (2014) DOI: 10.1111/bph.12540, Rodríguez-Cueto et al. (2014) DOI: 10.1111/bph.12283, Stanley and O'Sullivan (2014) DOI: 10.1111/bph.12560, Toguri et al. (2014) DOI: 10.1111/bph.12545, Wu et al. (2014) DOI: 10.1111/bph.12500. Linked articles are: Avraham et al. (2014) DOI: 10.1111/bph.12478, Machado et al. (2014) DOI: 10.1111/bph.12488, Ward et al. (2014) DOI: 10.1111/bph.12439. © 2014 The British Pharmacological Society.

Complexity and Animal Models

DTIC Science & Technology

2015-01-01

ventricular fibrillation and cardiopulmonary resuscitation . The second presentation will be summarized below. doi:10.1016/j.jcrc.2010.05.013 Neural dynamics...hemorrhagic shock, resuscitation , trauma, inhalation injury, apnea, and other critical states. This research serves as a test bed for discovery

Seeing the forest and the trees: USGS scientist links local changes to global scale

USGS Publications Warehouse

Wilson, Jim; Allen, Craig D.

2011-01-01

The recent recipient of two major awards, Craig D. Allen, a research ecologist with the U.S. Geological Survey Fort Collins Science Center, has loved trees since childhood. He is now considered an expert of world renown on the twin phenomena of forest changes and tree mortality resulting from climate warming and drought, and in 2010 was twice recognized for his scientific contributions.In December 2010, Dr. Allen was named a 2010 Fellow of the American Association for the Advancement of Science “for outstanding leadership in the synthesis of global forest responses to climate change, built from worldwide collaboration and a deep understanding of the environmental history of the southwestern United States.”In March 2010, he was honored with the Meritorious Service Award from the U.S. Department of the Interior (DOI) in recognition of his outstanding vision, initiative, and scientific contributions to the USGS, DOI, and U.S. Department of Agriculture in establishing a model science program to support adaptive land management at the new Valles Caldera National Preserve in north-central New Mexico.Dr. Allen has authored more than 85 publications on landscape ecology and landscape change, from fire history and ecology to ecosystem responses to climate change. He has appeared on NOVA discussing fire ecology and on The Discovery Channel and Discovery Canada explaining the links between drought-induced tree mortality and climate warming, in addition to being interviewed and quoted in innumerable newspaper articles on both topics.But how did this unassuming scientist grow from nurturing maple saplings on 40 acres in Wisconsin to understanding forest system stress worldwide?

Using Rapid-Response Scenario-Building Methodology for Climate Change Adaptation Planning

NASA Astrophysics Data System (ADS)

Ludwig, K. A.; Stoepler, T. M.; Schuster, R.

2015-12-01

Rapid-response scenario-building methodology can be modified to develop scenarios for slow-onset disasters associated with climate change such as drought. Results of a collaboration between the Department of the Interior (DOI) Strategic Sciences Group (SSG) and the Southwest Colorado Social-Ecological Climate Resilience Project are presented in which SSG scenario-building methods were revised and applied to climate change adaptation planning in Colorado's Gunnison Basin, United States. The SSG provides the DOI with the capacity to rapidly assemble multidisciplinary teams of experts to develop scenarios of the potential environmental, social, and economic cascading consequences of environmental crises, and to analyze these chains to determine actionable intervention points. By design, the SSG responds to acute events of a relatively defined duration. As a capacity-building exercise, the SSG explored how its scenario-building methodology could be applied to outlining the cascading consequences of slow-onset events related to climate change. SSG staff facilitated two workshops to analyze the impacts of drought, wildfire, and insect outbreak in the sagebrush and spruce-fir ecosystems. Participants included local land managers, natural and social scientists, ranchers, and other stakeholders. Key findings were: 1) scenario framing must be adjusted to accommodate the multiple, synergistic components and longer time frames of slow-onset events; 2) the development of slow-onset event scenarios is likely influenced by participants having had more time to consider potential consequences, relative to acute events; 3) participants who are from the affected area may have a more vested interest in the outcome and/or may be able to directly implement interventions.

Structure and transport mechanism of the sodium/proton antiporter MjNhaP1

PubMed Central

Paulino, Cristina; Wöhlert, David; Kapotova, Ekaterina; Yildiz, Özkan; Kühlbrandt, Werner

2014-01-01

Sodium/proton antiporters are essential for sodium and pH homeostasis and play a major role in human health and disease. We determined the structures of the archaeal sodium/proton antiporter MjNhaP1 in two complementary states. The inward-open state was obtained by x-ray crystallography in the presence of sodium at pH 8, where the transporter is highly active. The outward-open state was obtained by electron crystallography without sodium at pH 4, where MjNhaP1 is inactive. Comparison of both structures reveals a 7° tilt of the 6 helix bundle. 22Na+ uptake measurements indicate non-cooperative transport with an activity maximum at pH 7.5. We conclude that binding of a Na+ ion from the outside induces helix movements that close the extracellular cavity, open the cytoplasmic funnel, and result in a ∼5 Å vertical relocation of the ion binding site to release the substrate ion into the cytoplasm. DOI: http://dx.doi.org/10.7554/eLife.03583.001 PMID:25426803

P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila

PubMed Central

Hoopfer, Eric D; Jung, Yonil; Inagaki, Hidehiko K; Rubin, Gerald M; Anderson, David J

2015-01-01

How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner. DOI: http://dx.doi.org/10.7554/eLife.11346.001 PMID:26714106

Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche

PubMed Central

Wang, Su; Gao, Yuan; Song, Xiaoqing; Ma, Xing; Zhu, Xiujuan; Mao, Ying; Yang, Zhihao; Ni, Jianquan; Li, Hua; Malanowski, Kathryn E; Anoja, Perera; Park, Jungeun; Haug, Jeff; Xie, Ting

2015-01-01

Adult stem cells continuously undergo self-renewal and generate differentiated cells. In the Drosophila ovary, two separate niches control germ line stem cell (GSC) self-renewal and differentiation processes. Compared to the self-renewing niche, relatively little is known about the maintenance and function of the differentiation niche. In this study, we show that the cellular redox state regulated by Wnt signaling is critical for the maintenance and function of the differentiation niche to promote GSC progeny differentiation. Defective Wnt signaling causes the loss of the differentiation niche and the upregulated BMP signaling in differentiated GSC progeny, thereby disrupting germ cell differentiation. Mechanistically, Wnt signaling controls the expression of multiple glutathione-S-transferase family genes and the cellular redox state. Finally, Wnt2 and Wnt4 function redundantly to maintain active Wnt signaling in the differentiation niche. Therefore, this study has revealed a novel strategy for Wnt signaling in regulating the cellular redox state and maintaining the differentiation niche. DOI: http://dx.doi.org/10.7554/eLife.08174.001 PMID:26452202

Perchlorate in the Hydrologic Cycle - An Overview of Sources and Occurrence

NASA Astrophysics Data System (ADS)

Stonestrom, D. A.; Jackson, W.; Mayer, K.; Orris, G. J.

2007-12-01

Perchlorate (ClO4-) in water and food is of concern due to deleterious health affects associated with hypothyroidism. The presence of widespread perchlorate in 0-to-28 ka-old pristine ground water of the Middle Rio Grande Basin (Plummer et al., 2006, ES&T, DOI:10.1021/es051739h), in ground water >1 mile from agricultural activities in the Southern High Plains (Rajagapolan et al., 2006, ES&T, DOI:10.1021/es052155i), and in unsaturated zones throughout the arid and semiarid southwestern United States (Rao et al., 2007, ES&T, DOI:10.1021/es062853i) clearly indicates that perchlorate is a non-exotic component of the hydrologic cycle, at least in dry environments. The natural system has been greatly perturbed in places by human activities. Most anthropogenic inputs are associated with the manufacture and use of explosives and rocket fuel, providing concentrated sources of excess perchlorate to the hydrologic cycle. Perchlorate-containing fertilizers and irrigation provide dispersed sources within and down-gradient from agricultural areas. Natural sources include photochemically mediated reactions involving ozone at the land surface and in the lower atmosphere. A growing body of work indicates that a small, but persistent, meteoric source acting over thousands of years can explain observed accumulations of unsaturated-zone perchlorate in arid regions. In addition to meteoric sources, oxyanions produced during volcanogenic processes can include appreciable amounts of natural perchlorate. Terrestrial plants take up perchlorate in soil water, with some species of xerophytic succulents concentrating the anion to high levels. Similarly, perchlorate in marine plants indicates that perchlorate is part of marine biochemical cycles. Perchlorate-bearing marine sediments of late Tertiary age suggest that perchlorate has been part of global geochemical cycles for millions of years and, furthermore, can be preserved in the subsurface despite the nearly ubiquitous presence of perchlorate-reducing bacteria in natural environments. New methods involving various combinations of ion chromatography, mass spectroscopy, and molecular biology are providing improved tools for understanding perchlorate in natural and perturbed systems. With large-scale sampling underway, a better understanding of the sources, sinks, and transformations of perchlorate in the hydrologic cycle is starting to emerge.

Stress Variation Caused by the Terrestrial Water Storage Inferred from GRACE Data

NASA Astrophysics Data System (ADS)

Yi, H.; Wen, L.

2014-12-01

We estimate stress variation caused by the terrestrial water storage (TWS) change from 2003 to 2013. We first infer the TWS change from the monthly gravity field change in the Gravity Recovery and Climate Experiment (GRACE). We then estimate the stress change at the Earth's surface caused by elastic loading of mass change associated with the inferred TWS change.The monthly spherical harmonics of the GRACE gravity solutions are processed using a decorrelation filter and Gaussian smoothing, to suppress the noise in high degree and order, following the approach of Swenson and Wahr [2006] and Chen et al. [2007]. The gravity variation associated with the glacial isostatic adjustment (GIA) is further removed from the GRACE solutions based on a geodynamical model by Paulson et al. [2007]. The inferred TWS changes exhibit a trend of increase from 2003 to 2013 in Amazon basin, southern Africa, the northern United State America (USA) and Queen Maud Land of Antarctica, and a trend of decrease in the same period in central Argentina, southern Chile, northern India, northern Iran, Alaska of the USA, Greenland and Marie Byrd Land of Antarctica.Surface stress variation due to the TWS loading is calculated, assuming an incompressible and self-gravitating Earth, with an elastic crust and a viscoelastic mantle overlying an inviscid core based on PREM model. We will present the geographical distribution of the stress variation caused by the TWS loading and discuss its possible implications. Chen, J. L., C. R. Wilson, B. D. Tapley, and S. Grand (2007), GRACE detects coseismic and postseismic deformation from the Sumatra-Andaman earthquake, Geophys Res Lett, 34(13), doi:10.1029/2007GL030356. Paulson, A., S. J. Zhong, and J. Wahr (2007), Inference of mantle viscosity from GRACE and relative sea level data, Geophys J Int, 171(2), 497-508, doi:10.1111/j.1365-246X.2007.03556.x. Swenson, S., and J. Wahr (2006), Post-processing removal of correlated errors in GRACE data, Geophys Res Lett, 33(8), doi:10.1029/2005GL025285.

Potential effects of existing and proposed groundwater withdrawals on water levels and natural groundwater discharge in Snake Valley and surrounding areas, Utah and Nevada

USGS Publications Warehouse

Masbruch, Melissa D.; Brooks, Lynette E.

2017-04-14

Several U.S. Department of Interior (DOI) agencies are concerned about the cumulative effects of groundwater development on groundwater resources managed by, and other groundwater resources of interest to, these agencies in Snake Valley and surrounding areas. The new water uses that potentially concern the DOI agencies include 12 water-right applications filed in 2005, totaling approximately 8,864 acre-feet per year. To date, only one of these applications has been approved and partially developed. In addition, the DOI agencies are interested in the potential effects of three new water-right applications (UT 18-756, UT 18-758, and UT 18-759) and one water-right change application (UT a40687), which were the subject of a water-right hearing on April 19, 2016.This report presents a hydrogeologic analysis of areas in and around Snake Valley to assess potential effects of existing and future groundwater development on groundwater resources, specifically groundwater discharge sites, of interest to the DOI agencies. A previously developed steady-state numerical groundwater-flow model was modified to transient conditions with respect to well withdrawals and used to quantify drawdown and capture (withdrawals that result in depletion) of natural discharge from existing and proposed groundwater withdrawals. The original steady-state model simulates and was calibrated to 2009 conditions. To investigate the potential effects of existing and proposed groundwater withdrawals on the groundwater resources of interest to the DOI agencies, 10 withdrawal scenarios were simulated. All scenarios were simulated for periods of 5, 10, 15, 30, 55, and 105 years from the start of 2010; additionally, all scenarios were simulated to a new steady state to determine the ultimate long-term effects of the withdrawals. Capture maps were also constructed as part of this analysis. The simulations used to develop the capture maps test the response of the system, specifically the reduction of natural discharge, to future stresses at a point in the area represented by the model. In this way, these maps can be used as a tool to determine the source of water to, and potential effects at specific areas from, future well withdrawals.Downward trends in water levels measured in wells indicate that existing groundwater withdrawals in Snake Valley are affecting water levels. The numerical model simulates similar downward trends in water levels; simulated drawdowns in the model, however, are generally less than observed water-level declines. At the groundwater discharge sites of interest to the DOI agencies, simulated drawdowns from existing well withdrawals (projected into the future) range from 0 to about 50 feet. Following the addition of the proposed withdrawals, simulated drawdowns at some sites increase by 25 feet. Simulated drawdown resulting from the proposed withdrawals began in as few as 5 years after 2014 at several of the sites. At the groundwater discharge sites of interest to the DOI agencies, simulated capture of natural discharge resulting from the existing withdrawals ranged from 0 to 87 percent. Following the addition of the proposed withdrawals, simulated capture at several of the sites reached 100 percent, indicating that groundwater discharge at that site would cease. Simulated capture following the addition of the proposed withdrawals increased in as few as 5 years after 2014 at several of the sites.

Cooperative Fish and Wildlife Research Units Program—2017 year in review postcard

USGS Publications Warehouse

Organ, John F.; Thompson, John D.; Dennerline, Donald E.; Childs, Dawn E.

2018-02-08

This postcard provides details about the Cooperative Fish and Wildlife Research Units Program—2017 Year in Review, U.S. Geological Survey Circular 1438, now available at https://doi.org/10.3133/cir1438. In this report, you will find details about the Cooperative Fish and Wildlife Research Units (CRU) Program relating to its background, fish and wildlife science, students, staffing, vacancies, research funding, outreach and training, science themes, accolades, and professional services. You will see snapshots of CRU projects with information on how results have been or are being applied by cooperators. This is the essence of what we do: science that matters.Throughout the year, keep up with CRU research projects at http://www.coopunits.org.

No universal scale-dependent impacts of invasive species on native plant species richness.

PubMed

Stohlgren, Thomas J; Rejmánek, Marcel

2014-01-01

A growing number of studies seeking generalizations about the impact of plant invasions compare heavily invaded sites to uninvaded sites. But does this approach warrant any generalizations? Using two large datasets from forests, grasslands and desert ecosystems across the conterminous United States, we show that (i) a continuum of invasion impacts exists in many biomes and (ii) many possible species-area relationships may emerge reflecting a wide range of patterns of co-occurrence of native and alien plant species. Our results contradict a smaller recent study by Powell et al. 2013 (Science 339, 316-318. (doi:10.1126/science.1226817)), who compared heavily invaded and uninvaded sites in three biomes and concluded that plant communities invaded by non-native plant species generally have lower local richness (intercepts of log species richness-log area regression lines) but steeper species accumulation with increasing area (slopes of the regression lines) than do uninvaded communities. We conclude that the impacts of plant invasions on plant species richness are not universal.

STS-87 P.S. Leonid Kadenyuk of NSAU and Daniel Goldin after landing

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine (NSAU), at left, greets NASA Administrator Daniel Goldin, at right, as back-up Payload Specialist Yaroslav Pustovyi, also of NSAU, looks on. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16-hour and 34-minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Commander Kevin Kregel; Pilot Steven Lindsey; and Mission Specialists Winston Scott; Kalpana Chawla, Ph.D.; and Takao Doi, Ph.D. of the National Space Development Agency of Japan. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

STS-87 crew pose in front of the orbiter Columbia after landing

NASA Technical Reports Server (NTRS)

1997-01-01

The STS-87 crew pose in front of the orbiter Columbia shortly after landing on Runway 33 at KSC's Shuttle Landing Facility. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, drawing the 15-day, 16-hour and 34- minute-long mission of 6.5 million miles to a close. From left to right are Mission Specialists Winston Scott and Takao Doi, Ph.D., of the National Space Development Agency of Japan; Commander Kevin Kregel; Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine; Mission Specialist Kalpana Chawla, Ph.D.; and Pilot Steven Lindsey. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942.

PubMed

Watanabe, Satoru; Ozawa, Hiroaki; Kato, Hiroaki; Nimura-Matsune, Kaori; Hirayama, Toshifumi; Kudo, Fumitaka; Eguchi, Tadashi; Kakinuma, Katsumi; Yoshikawa, Hirofumi

2018-01-01

Owing to their photosynthetic capabilities, there is increasing interest in utilizing cyanobacteria to convert solar energy into biomass. 2-Deoxy-scyllo-inosose (DOI) is a valuable starting material for the benzene-free synthesis of catechol and other benzenoids. DOI synthase (DOIS) is responsible for the formation of DOI from d-glucose-6-phosphate (G6P) in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics such as neomycin and butirosin. DOI fermentation using a recombinant Escherichia coli strain has been reported, although a carbon source is necessary for high-yield DOI production. We constructed DOI-producing cyanobacteria toward carbon-free and sustainable DOI production. A DOIS gene derived from the butirosin producer strain Bacillus circulans (btrC) was introduced and expressed in the cyanobacterium Synechococcus elongatus PCC 7942. We ultimately succeeded in producing 400 mg/L of DOI in S. elongatus without using a carbon source. DOI production by cyanobacteria represents a novel and efficient approach for producing benzenoids from G6P synthesized by photosynthesis.

The computational nature of memory modification

PubMed Central

Gershman, Samuel J; Monfils, Marie-H; Norman, Kenneth A; Niv, Yael

2017-01-01

Retrieving a memory can modify its influence on subsequent behavior. We develop a computational theory of memory modification, according to which modification of a memory trace occurs through classical associative learning, but which memory trace is eligible for modification depends on a structure learning mechanism that discovers the units of association by segmenting the stream of experience into statistically distinct clusters (latent causes). New memories are formed when the structure learning mechanism infers that a new latent cause underlies current sensory observations. By the same token, old memories are modified when old and new sensory observations are inferred to have been generated by the same latent cause. We derive this framework from probabilistic principles, and present a computational implementation. Simulations demonstrate that our model can reproduce the major experimental findings from studies of memory modification in the Pavlovian conditioning literature. DOI: http://dx.doi.org/10.7554/eLife.23763.001 PMID:28294944

Peripherally administered orexin improves survival of mice with endotoxin shock

PubMed Central

Ogawa, Yasuhiro; Irukayama-Tomobe, Yoko; Murakoshi, Nobuyuki; Kiyama, Maiko; Ishikawa, Yui; Hosokawa, Naoto; Tominaga, Hiromu; Uchida, Shuntaro; Kimura, Saki; Kanuka, Mika; Morita, Miho; Hamada, Michito; Takahashi, Satoru; Hayashi, Yu; Yanagisawa, Masashi

2016-01-01

Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of death in intensive care units. Here, we report that peripheral administration of the hypothalamic neuropeptide orexin improves the survival of mice with lipopolysaccharide (LPS) induced endotoxin shock, a well-studied septic shock model. The effect is accompanied by a suppression of excessive cytokine production and an increase of catecholamines and corticosterone. We found that peripherally administered orexin penetrates the blood-brain barrier under endotoxin shock, and that central administration of orexin also suppresses the cytokine production and improves the survival, indicating orexin’s direct action in the central nervous system (CNS). Orexin helps restore body temperature and potentiates cardiovascular function in LPS-injected mice. Pleiotropic modulation of inflammatory response by orexin through the CNS may constitute a novel therapeutic approach for septic shock. DOI: http://dx.doi.org/10.7554/eLife.21055.001 PMID:28035899

Process Architecture for Managing Digital Object Identifiers

NASA Astrophysics Data System (ADS)

Wanchoo, L.; James, N.; Stolte, E.

2014-12-01

In 2010, NASA's Earth Science Data and Information System (ESDIS) Project implemented a process for registering Digital Object Identifiers (DOIs) for data products distributed by Earth Observing System Data and Information System (EOSDIS). For the first 3 years, ESDIS evolved the process involving the data provider community in the development of processes for creating and assigning DOIs, and guidelines for the landing page. To accomplish this, ESDIS established two DOI User Working Groups: one for reviewing the DOI process whose recommendations were submitted to ESDIS in February 2014; and the other recently tasked to review and further develop DOI landing page guidelines for ESDIS approval by end of 2014. ESDIS has recently upgraded the DOI system from a manually-driven system to one that largely automates the DOI process. The new automated feature include: a) reviewing the DOI metadata, b) assigning of opaque DOI name if data provider chooses, and c) reserving, registering, and updating the DOIs. The flexibility of reserving the DOI allows data providers to embed and test the DOI in the data product metadata before formally registering with EZID. The DOI update process allows the changing of any DOI metadata except the DOI name unless the name has not been registered. Currently, ESDIS has processed a total of 557 DOIs of which 379 DOIs are registered with EZID and 178 are reserved with ESDIS. The DOI incorporates several metadata elements that effectively identify the data product and the source of availability. Of these elements, the Uniform Resource Locator (URL) attribute has the very important function of identifying the landing page which describes the data product. ESDIS in consultation with data providers in the Earth Science community is currently developing landing page guidelines that specify the key data product descriptive elements to be included on each data product's landing page. This poster will describe in detail the unique automated process and underlying system implemented by ESDIS for registering DOIs, as well as some of the lessons learned from the development of the process. In addition, this paper will summarize the recommendations made by the DOI Process and DOI Landing Page User Working Groups, and the procedures developed for implementing those recommendations.

KSC-07pd2829

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, STS-123 Mission Specialist Takao Doi (left) and Commander Dominic Gorie confer about the mission payload, the Kibo Experiment Logistics Module Pressurized Section, they are looking over. They are at the center for a crew equipment interface test, which allows familiarization with equipment they will use during the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

Learning LM Specificity for Ganglion Cells

NASA Technical Reports Server (NTRS)

Ahumada, Albert J.

2015-01-01

Unsupervised learning models have been proposed based on experience (Ahumada and Mulligan, 1990;Wachtler, Doi, Lee and Sejnowski, 2007) that allow the cortex to develop units with LM specific color opponent receptive fields like the blob cells reported by Hubel and Wiesel on the basis of visual experience. These models used ganglion cells with LM indiscriminate wiring as inputs to the learning mechanism, which was presumed to occur at the cortical level.

Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

PubMed

Roepke, T A; Smith, A W; Rønnekleiv, O K; Kelly, M J

2012-06-01

Hypothalamic proopiomelanocortin (POMC) neurons are controlled by many central signals, including serotonin. Serotonin increases POMC activity and reduces feeding behavior via serotonion [5-hydroxytryptamine (5-HT)] receptors by modulating K(+) currents. A potential K(+) current is the M-current, a noninactivating, subthreshold outward K(+) current. Previously, we found that M-current activity was highly reduced in fasted vs. fed states in neuropeptide Y neurons. Because POMC neurons also respond to energy states, we hypothesized that fasting may alter the M-current and/or its modulation by serotonergic input to POMC neurons. Using visualized-patch recording in neurons from fed male enhanced green fluorescent protein-POMC transgenic mice, we established that POMC neurons expressed a robust M-current (102.1 ± 6.7 pA) that was antagonized by the selective KCNQ channel blocker XE-991 (40 μM). However, the XE-991-sensitive current in POMC neurons did not differ between fed and fasted states. To determine if serotonin suppresses the M-current via the 5-HT(2C) receptor, we examined the effects of the 5-HT(2A)/5-HT(2C) receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on the M-current. Indeed, DOI attenuated the M-current by 34.5 ± 6.9% and 42.0 ± 5.3% in POMC neurons from fed and fasted male mice, respectively. In addition, the 5-HT(1B)/5-HT(2C) receptor agonist m-chlorophenylpiperazine attenuated the M-current by 42.4 ± 5.4% in POMC neurons from fed male mice. Moreover, the selective 5-HT(2C) receptor antagonist RS-102221 abrogated the actions of DOI in suppressing the M-current. Collectively, these data suggest that although M-current expression does not differ between fed and fasted states in POMC neurons, serotonin inhibits the M-current via activation of 5-HT(2C) receptors to increase POMC neuronal excitability and, subsequently, reduce food intake.

Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex

PubMed Central

Kaufman, Matthew T; Churchland, Mark M; Ryu, Stephen I; Shenoy, Krishna V

2015-01-01

When choosing actions, we can act decisively, vacillate, or suffer momentary indecision. Studying how individual decisions unfold requires moment-by-moment readouts of brain state. Here we provide such a view from dorsal premotor and primary motor cortex. Two monkeys performed a novel decision task while we recorded from many neurons simultaneously. We found that a decoder trained using ‘forced choices’ (one target viable) was highly reliable when applied to ‘free choices’. However, during free choices internal events formed three categories. Typically, neural activity was consistent with rapid, unwavering choices. Sometimes, though, we observed presumed ‘changes of mind’: the neural state initially reflected one choice before changing to reflect the final choice. Finally, we observed momentary ‘indecision’: delay forming any clear motor plan. Further, moments of neural indecision accompanied moments of behavioral indecision. Together, these results reveal the rich and diverse set of internal events long suspected to occur during free choice. DOI: http://dx.doi.org/10.7554/eLife.04677.001 PMID:25942352

Discovering sparse transcription factor codes for cell states and state transitions during development

PubMed Central

Furchtgott, Leon A; Melton, Samuel; Menon, Vilas; Ramanathan, Sharad

2017-01-01

Computational analysis of gene expression to determine both the sequence of lineage choices made by multipotent cells and to identify the genes influencing these decisions is challenging. Here we discover a pattern in the expression levels of a sparse subset of genes among cell types in B- and T-cell developmental lineages that correlates with developmental topologies. We develop a statistical framework using this pattern to simultaneously infer lineage transitions and the genes that determine these relationships. We use this technique to reconstruct the early hematopoietic and intestinal developmental trees. We extend this framework to analyze single-cell RNA-seq data from early human cortical development, inferring a neocortical-hindbrain split in early progenitor cells and the key genes that could control this lineage decision. Our work allows us to simultaneously infer both the identity and lineage of cell types as well as a small set of key genes whose expression patterns reflect these relationships. DOI: http://dx.doi.org/10.7554/eLife.20488.001 PMID:28296636

Unexpected arousal modulates the influence of sensory noise on confidence

PubMed Central

Allen, Micah; Frank, Darya; Schwarzkopf, D Samuel; Fardo, Francesca; Winston, Joel S; Hauser, Tobias U; Rees, Geraint

2016-01-01

Human perception is invariably accompanied by a graded feeling of confidence that guides metacognitive awareness and decision-making. It is often assumed that this arises solely from the feed-forward encoding of the strength or precision of sensory inputs. In contrast, interoceptive inference models suggest that confidence reflects a weighted integration of sensory precision and expectations about internal states, such as arousal. Here we test this hypothesis using a novel psychophysical paradigm, in which unseen disgust-cues induced unexpected, unconscious arousal just before participants discriminated motion signals of variable precision. Across measures of perceptual bias, uncertainty, and physiological arousal we found that arousing disgust cues modulated the encoding of sensory noise. Furthermore, the degree to which trial-by-trial pupil fluctuations encoded this nonlinear interaction correlated with trial level confidence. Our results suggest that unexpected arousal regulates perceptual precision, such that subjective confidence reflects the integration of both external sensory and internal, embodied states. DOI: http://dx.doi.org/10.7554/eLife.18103.001 PMID:27776633

Capturing the temporal evolution of choice across prefrontal cortex

PubMed Central

Hunt, Laurence T; Behrens, Timothy EJ; Hosokawa, Takayuki; Wallis, Jonathan D; Kennerley, Steven W

2015-01-01

Activity in prefrontal cortex (PFC) has been richly described using economic models of choice. Yet such descriptions fail to capture the dynamics of decision formation. Describing dynamic neural processes has proven challenging due to the problem of indexing the internal state of PFC and its trial-by-trial variation. Using primate neurophysiology and human magnetoencephalography, we here recover a single-trial index of PFC internal states from multiple simultaneously recorded PFC subregions. This index can explain the origins of neural representations of economic variables in PFC. It describes the relationship between neural dynamics and behaviour in both human and monkey PFC, directly bridging between human neuroimaging data and underlying neuronal activity. Moreover, it reveals a functionally dissociable interaction between orbitofrontal cortex, anterior cingulate cortex and dorsolateral PFC in guiding cost-benefit decisions. We cast our observations in terms of a recurrent neural network model of choice, providing formal links to mechanistic dynamical accounts of decision-making. DOI: http://dx.doi.org/10.7554/eLife.11945.001 PMID:26653139

A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by Gαs signaling

PubMed Central

Nagy, Stanislav; Wright, Charles; Tramm, Nora; Labello, Nicholas; Burov, Stanislav; Biron, David

2013-01-01

Despite their simplicity, longitudinal studies of invertebrate models are rare. We thus sought to characterize behavioral trends of Caenorhabditis elegans, from the mid fourth larval stage through the mid young adult stage. We found that, outside of lethargus, animals exhibited abrupt switching between two distinct behavioral states: active wakefulness and quiet wakefulness. The durations of epochs of active wakefulness exhibited non-Poisson statistics. Increased Gαs signaling stabilized the active wakefulness state before, during and after lethargus. In contrast, decreased Gαs signaling, decreased neuropeptide release, or decreased CREB activity destabilized active wakefulness outside of, but not during, lethargus. Taken together, our findings support a model in which protein kinase A (PKA) stabilizes active wakefulness, at least in part through two of its downstream targets: neuropeptide release and CREB. However, during lethargus, when active wakefulness is strongly suppressed, the native role of PKA signaling in modulating locomotion and quiescence may be minor. DOI: http://dx.doi.org/10.7554/eLife.00782.001 PMID:23840929

Attentional modulation of neuronal variability in circuit models of cortex

PubMed Central

Kanashiro, Tatjana; Ocker, Gabriel Koch; Cohen, Marlene R; Doiron, Brent

2017-01-01

The circuit mechanisms behind shared neural variability (noise correlation) and its dependence on neural state are poorly understood. Visual attention is well-suited to constrain cortical models of response variability because attention both increases firing rates and their stimulus sensitivity, as well as decreases noise correlations. We provide a novel analysis of population recordings in rhesus primate visual area V4 showing that a single biophysical mechanism may underlie these diverse neural correlates of attention. We explore model cortical networks where top-down mediated increases in excitability, distributed across excitatory and inhibitory targets, capture the key neuronal correlates of attention. Our models predict that top-down signals primarily affect inhibitory neurons, whereas excitatory neurons are more sensitive to stimulus specific bottom-up inputs. Accounting for trial variability in models of state dependent modulation of neuronal activity is a critical step in building a mechanistic theory of neuronal cognition. DOI: http://dx.doi.org/10.7554/eLife.23978.001 PMID:28590902

Beta band oscillations in motor cortex reflect neural population signals that delay movement onset

PubMed Central

Khanna, Preeya; Carmena, Jose M

2017-01-01

Motor cortical beta oscillations have been reported for decades, yet their behavioral correlates remain unresolved. Some studies link beta oscillations to changes in underlying neural activity, but the specific behavioral manifestations of these reported changes remain elusive. To investigate how changes in population neural activity, beta oscillations, and behavior are linked, we recorded multi-scale neural activity from motor cortex while three macaques performed a novel neurofeedback task. Subjects volitionally brought their beta oscillatory power to an instructed state and subsequently executed an arm reach. Reaches preceded by a reduction in beta power exhibited significantly faster movement onset times than reaches preceded by an increase in beta power. Further, population neural activity was found to shift farther from a movement onset state during beta oscillations that were neurofeedback-induced or naturally occurring during reaching tasks. This finding establishes a population neural basis for slowed movement onset following periods of beta oscillatory activity. DOI: http://dx.doi.org/10.7554/eLife.24573.001 PMID:28467303

Rhythmic coordination of hippocampal neurons during associative memory processing

PubMed Central

Rangel, Lara M; Rueckemann, Jon W; Riviere, Pamela D; Keefe, Katherine R; Porter, Blake S; Heimbuch, Ian S; Budlong, Carl H; Eichenbaum, Howard

2016-01-01

Hippocampal oscillations are dynamic, with unique oscillatory frequencies present during different behavioral states. To examine the extent to which these oscillations reflect neuron engagement in distinct local circuit processes that are important for memory, we recorded single cell and local field potential activity from the CA1 region of the hippocampus as rats performed a context-guided odor-reward association task. We found that theta (4–12 Hz), beta (15–35 Hz), low gamma (35–55 Hz), and high gamma (65–90 Hz) frequencies exhibited dynamic amplitude profiles as rats sampled odor cues. Interneurons and principal cells exhibited unique engagement in each of the four rhythmic circuits in a manner that related to successful performance of the task. Moreover, principal cells coherent to each rhythm differentially represented task dimensions. These results demonstrate that distinct processing states arise from the engagement of rhythmically identifiable circuits, which have unique roles in organizing task-relevant processing in the hippocampus. DOI: http://dx.doi.org/10.7554/eLife.09849.001 PMID:26751780

Identification of a pre-active conformation of a pentameric channel receptor

PubMed Central

Menny, Anaïs; Lefebvre, Solène N; Schmidpeter, Philipp AM; Drège, Emmanuelle; Fourati, Zaineb; Delarue, Marc; Edelstein, Stuart J; Nimigean, Crina M; Joseph, Delphine; Corringer, Pierre-Jean

2017-01-01

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling through global allosteric transitions. Despite the existence of several high-resolution structures of pLGICs, their dynamical properties remain elusive. Using the proton-gated channel GLIC, we engineered multiple fluorescent reporters, each incorporating a bimane and a tryptophan/tyrosine, whose close distance causes fluorescence quenching. We show that proton application causes a global compaction of the extracellular subunit interface, coupled to an outward motion of the M2-M3 loop near the channel gate. These movements are highly similar in lipid vesicles and detergent micelles. These reorganizations are essentially completed within 2 ms and occur without channel opening at low proton concentration, indicating that they report a pre-active intermediate state in the transition pathway toward activation. This provides a template to investigate the gating of eukaryotic neurotransmitter receptors, for which intermediate states also participate in activation. DOI: http://dx.doi.org/10.7554/eLife.23955.001 PMID:28294942

Flowering time and seed dormancy control use external coincidence to generate life history strategy

PubMed Central

Springthorpe, Vicki; Penfield, Steven

2015-01-01

Climate change is accelerating plant developmental transitions coordinated with the seasons in temperate environments. To understand the importance of these timing advances for a stable life history strategy, we constructed a full life cycle model of Arabidopsis thaliana. Modelling and field data reveal that a cryptic function of flowering time control is to limit seed set of winter annuals to an ambient temperature window which coincides with a temperature-sensitive switch in seed dormancy state. This coincidence is predicted to be conserved independent of climate at the expense of flowering date, suggesting that temperature control of flowering time has evolved to constrain seed set environment and therefore frequency of dormant and non-dormant seed states. We show that late flowering can disrupt this bet-hedging germination strategy. Our analysis shows that life history modelling can reveal hidden fitness constraints and identify non-obvious selection pressures as emergent features. DOI: http://dx.doi.org/10.7554/eLife.05557.001 PMID:25824056

Long-distance communication by specialized cellular projections during pigment pattern development and evolution

PubMed Central

Eom, Dae Seok; Bain, Emily J; Patterson, Larissa B; Grout, Megan E; Parichy, David M

2015-01-01

Changes in gene activity are essential for evolutionary diversification. Yet, elucidating the cellular behaviors that underlie modifications to adult form remains a profound challenge. We use neural crest-derived adult pigmentation of zebrafish and pearl danio to uncover cellular bases for alternative pattern states. We show that stripes in zebrafish require a novel class of thin, fast cellular projection to promote Delta-Notch signaling over long distances from cells of the xanthophore lineage to melanophores. Projections depended on microfilaments and microtubules, exhibited meandering trajectories, and stabilized on target cells to which they delivered membraneous vesicles. By contrast, the uniformly patterned pearl danio lacked such projections, concomitant with Colony stimulating factor 1-dependent changes in xanthophore differentiation that likely curtail signaling available to melanophores. Our study reveals a novel mechanism of cellular communication, roles for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a striking difference in adult form. DOI: http://dx.doi.org/10.7554/eLife.12401.001 PMID:26701906

Deconstruction of the Ras switching cycle through saturation mutagenesis

PubMed Central

Bandaru, Pradeep; Shah, Neel H; Bhattacharyya, Moitrayee; Barton, John P; Kondo, Yasushi; Cofsky, Joshua C; Gee, Christine L; Chakraborty, Arup K; Kortemme, Tanja; Ranganathan, Rama; Kuriyan, John

2017-01-01

Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-dependent switching between active and inactive states. The high conservation of Ras requires mechanistic explanation, especially given the general mutational tolerance of proteins. Here, we use deep mutational scanning, biochemical analysis and molecular simulations to understand constraints on Ras sequence. Ras exhibits global sensitivity to mutation when regulated by a GTPase activating protein and a nucleotide exchange factor. Removing the regulators shifts the distribution of mutational effects to be largely neutral, and reveals hotspots of activating mutations in residues that restrain Ras dynamics and promote the inactive state. Evolutionary analysis, combined with structural and mutational data, argue that Ras has co-evolved with its regulators in the vertebrate lineage. Overall, our results show that sequence conservation in Ras depends strongly on the biochemical network in which it operates, providing a framework for understanding the origin of global selection pressures on proteins. DOI: http://dx.doi.org/10.7554/eLife.27810.001 PMID:28686159

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

PubMed Central

Zhou, Anna; Rohou, Alexis; Schep, Daniel G; Bason, John V; Montgomery, Martin G; Walker, John E; Grigorieff, Nikolaus; Rubinstein, John L

2015-01-01

Adenosine triphosphate (ATP), the chemical energy currency of biology, is synthesized in eukaryotic cells primarily by the mitochondrial ATP synthase. ATP synthases operate by a rotary catalytic mechanism where proton translocation through the membrane-inserted FO region is coupled to ATP synthesis in the catalytic F1 region via rotation of a central rotor subcomplex. We report here single particle electron cryomicroscopy (cryo-EM) analysis of the bovine mitochondrial ATP synthase. Combining cryo-EM data with bioinformatic analysis allowed us to determine the fold of the a subunit, suggesting a proton translocation path through the FO region that involves both the a and b subunits. 3D classification of images revealed seven distinct states of the enzyme that show different modes of bending and twisting in the intact ATP synthase. Rotational fluctuations of the c8-ring within the FO region support a Brownian ratchet mechanism for proton-translocation-driven rotation in ATP synthases. DOI: http://dx.doi.org/10.7554/eLife.10180.001 PMID:26439008

Target Control in Logical Models Using the Domain of Influence of Nodes.

PubMed

Yang, Gang; Gómez Tejeda Zañudo, Jorge; Albert, Réka

2018-01-01

Dynamical models of biomolecular networks are successfully used to understand the mechanisms underlying complex diseases and to design therapeutic strategies. Network control and its special case of target control, is a promising avenue toward developing disease therapies. In target control it is assumed that a small subset of nodes is most relevant to the system's state and the goal is to drive the target nodes into their desired states. An example of target control would be driving a cell to commit to apoptosis (programmed cell death). From the experimental perspective, gene knockout, pharmacological inhibition of proteins, and providing sustained external signals are among practical intervention techniques. We identify methodologies to use the stabilizing effect of sustained interventions for target control in Boolean network models of biomolecular networks. Specifically, we define the domain of influence (DOI) of a node (in a certain state) to be the nodes (and their corresponding states) that will be ultimately stabilized by the sustained state of this node regardless of the initial state of the system. We also define the related concept of the logical domain of influence (LDOI) of a node, and develop an algorithm for its identification using an auxiliary network that incorporates the regulatory logic. This way a solution to the target control problem is a set of nodes whose DOI can cover the desired target node states. We perform greedy randomized adaptive search in node state space to find such solutions. We apply our strategy to in silico biological network models of real systems to demonstrate its effectiveness.

Boosting electrical conductivity in a gel-derived material by nanostructuring with trace carbon nanotubes

NASA Astrophysics Data System (ADS)

Canevet, David; Pérez Del Pino, Angel; Amabilino, David B.; Sallé, Marc

2011-07-01

An organogelator with two distinct π-functional units is able to incorporate carbon nanotubes into its mesh of fibres in the gel state. The morphology of the material derived from this nanocomposite after evaporation of the solvent is a complex mesh of fibres which is clearly different from the pure gelator. This feature indicates a role of the nanotubes in assisting the formation of a fibre structure in the gel thanks to their interaction with the pyrene units in the organogelator. The nanocomposite conducts electricity once the p-type gelator is doped with iodine vapour. The change in morphology caused by the carbon material increases the conductivity of the material compared with the purely organic conducting system. It is remarkable that this improvement in the physical property is caused by an extremely small proportion of the carbon material (only present at a ratio of 0.1% w/w). The practically unique properties of TTF unit allow measurements with both doped and undoped materials with conducting atomic force microscopy which have demonstrated that the carbon nanotubes are not directly responsible for the increased conductivity.An organogelator with two distinct π-functional units is able to incorporate carbon nanotubes into its mesh of fibres in the gel state. The morphology of the material derived from this nanocomposite after evaporation of the solvent is a complex mesh of fibres which is clearly different from the pure gelator. This feature indicates a role of the nanotubes in assisting the formation of a fibre structure in the gel thanks to their interaction with the pyrene units in the organogelator. The nanocomposite conducts electricity once the p-type gelator is doped with iodine vapour. The change in morphology caused by the carbon material increases the conductivity of the material compared with the purely organic conducting system. It is remarkable that this improvement in the physical property is caused by an extremely small proportion of the carbon material (only present at a ratio of 0.1% w/w). The practically unique properties of TTF unit allow measurements with both doped and undoped materials with conducting atomic force microscopy which have demonstrated that the carbon nanotubes are not directly responsible for the increased conductivity. Electronic supplementary information (ESI) available: Details concerning the preparation of 1-SWCNTs composite. See DOI: 10.1039/c1nr10235d

30 CFR 229.4 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Authority. 229.4 Section 229.4 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT DELEGATION TO STATES General Provisions § 229.4 Authority. The Secretary of the DOI is authorized under provisons of 30...

30 CFR 1229.4 - Authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Authority. 1229.4 Section 1229.4 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR Natural Resources Revenue DELEGATION TO STATES General Provisions § 1229.4 Authority. The Secretary of the DOI is authorized...

Sideslip estimation for articulated heavy vehicles at the limits of adhesion

NASA Astrophysics Data System (ADS)

Morrison, Graeme; Cebon, David

2016-11-01

Various active safety systems proposed for articulated heavy goods vehicles (HGVs) require an accurate estimate of vehicle sideslip angle. However in contrast to passenger cars, there has been minimal published research on sideslip estimation for articulated HGVs. State-of-the-art observers, which rely on linear vehicle models, perform poorly when manoeuvring near the limits of tyre adhesion. This paper investigates three nonlinear Kalman filters (KFs) for estimating the tractor sideslip angle of a tractor-semitrailer. These are compared to the current state-of-the-art, through computer simulations and vehicle test data. An unscented KF using a 5 degrees-of-freedom single-track vehicle model with linear adaptive tyres is found to substantially outperform the state-of-the-art linear KF across a range of test manoeuvres on different surfaces, both at constant speed and during emergency braking. Robustness of the observer to parameter uncertainty is also demonstrated. Data supporting this research can be accessed at http://dx.doi.org/10.17863/CAM.1234

Overall energy conversion efficiency of a photosynthetic vesicle

PubMed Central

Sener, Melih; Strumpfer, Johan; Singharoy, Abhishek; Hunter, C Neil; Schulten, Klaus

2016-01-01

The chromatophore of purple bacteria is an intracellular spherical vesicle that exists in numerous copies in the cell and that efficiently converts sunlight into ATP synthesis, operating typically under low light conditions. Building on an atomic-level structural model of a low-light-adapted chromatophore vesicle from Rhodobacter sphaeroides, we investigate the cooperation between more than a hundred protein complexes in the vesicle. The steady-state ATP production rate as a function of incident light intensity is determined after identifying quinol turnover at the cytochrome bc1 complex (cytb⁢c1) as rate limiting and assuming that the quinone/quinol pool of about 900 molecules acts in a quasi-stationary state. For an illumination condition equivalent to 1% of full sunlight, the vesicle exhibits an ATP production rate of 82 ATP molecules/s. The energy conversion efficiency of ATP synthesis at illuminations corresponding to 1%–5% of full sunlight is calculated to be 0.12–0.04, respectively. The vesicle stoichiometry, evolutionarily adapted to the low light intensities in the habitat of purple bacteria, is suboptimal for steady-state ATP turnover for the benefit of protection against over-illumination. DOI: http://dx.doi.org/10.7554/eLife.09541.001 PMID:27564854

Glaciological measurements and mass balances from Sperry Glacier, Montana, USA, years 2005-2015

NASA Astrophysics Data System (ADS)

Clark, Adam M.; Fagre, Daniel B.; Peitzsch, Erich H.; Reardon, Blase A.; Harper, Joel T.

2017-01-01

Glacier mass balance measurements help to provide an understanding of the behavior of glaciers and their response to local and regional climate. In 2005 the United States Geological Survey established a surface mass balance monitoring program on Sperry Glacier, Montana, USA. This project is the first quantitative study of mass changes of a glacier in the US northern Rocky Mountains and continues to the present. The following paper describes the methods used during the first 11 years of measurements and reports the associated results. From 2005 to 2015, Sperry Glacier had a cumulative mean mass balance loss of 4.37 m w.e. (water equivalent). The mean winter, summer, and annual glacier-wide mass balances were 2.92, -3.41, and -0.40 m w.e. yr-1 respectively. We derive these cumulative and mean results from an expansive data set of snow depth, snow density, and ablation measurements taken at selected points on the glacier. These data allow for the determination of mass balance point values and a time series of seasonal and annual glacier-wide mass balances for all 11 measurement years. We also provide measurements of glacier extent and accumulation areas for select years. All data have been submitted to the World Glacier Monitoring Service and are available at doi:10.5904/wgms-fog-2016-08. This foundational work provides valuable insight about Sperry Glacier and supplies additional data to the worldwide record of glaciers measured using the glaciological method. Future research will focus on the processes that control accumulation and ablation patterns across the glacier. Also we plan to examine the uncertainties related to our methods and eventually quantify a more robust estimate of error associated with our results.

Updating Hawaii Seismicity Catalogs with Systematic Relocations and Subspace Detectors

NASA Astrophysics Data System (ADS)

Okubo, P.; Benz, H.; Matoza, R. S.; Thelen, W. A.

2015-12-01

We continue the systematic relocation of seismicity recorded in Hawai`i by the United States Geological Survey's (USGS) Hawaiian Volcano Observatory (HVO), with interests in adding to the products derived from the relocated seismicity catalogs published by Matoza et al., (2013, 2014). Another goal of this effort is updating the systematically relocated HVO catalog since 2009, when earthquake cataloging at HVO was migrated to the USGS Advanced National Seismic System Quake Management Software (AQMS) systems. To complement the relocation analyses of the catalogs generated from traditional STA/LTA event-triggered and analyst-reviewed approaches, we are also experimenting with subspace detection of events at Kilauea as a means to augment AQMS procedures for cataloging seismicity to lower magnitudes and during episodes of elevated volcanic activity. Our earlier catalog relocations have demonstrated the ability to define correlated or repeating families of earthquakes and provide more detailed definition of seismogenic structures, as well as the capability for improved automatic identification of diverse volcanic seismic sources. Subspace detectors have been successfully applied to cataloging seismicity in situations of low seismic signal-to-noise and have significantly increased catalog sensitivity to lower magnitude thresholds. We anticipate similar improvements using event subspace detections and cataloging of volcanic seismicity that include improved discrimination among not only evolving earthquake sequences but also diverse volcanic seismic source processes. Matoza et al., 2013, Systematic relocation of seismicity on Hawai`i Island from 1992 to 2009 using waveform cross correlation and cluster analysis, J. Geophys. Res., 118, 2275-2288, doi:10.1002/jgrb.580189 Matoza et al., 2014, High-precision relocation of long-period events beneath the summit region of Kīlauea Volcano, Hawai`i, from 1986 to 2009, Geophys. Res. Lett., 41, 3413-3421, doi:10.1002/2014GL059819

Implementing RDA Data Citation Recommendations: Case Study in South Africa

NASA Astrophysics Data System (ADS)

Hugo, Wim

2016-04-01

SAEON operates a shared research data infrastructure for its own data sets and for clients and end users in the Earth and Environmental Sciences domain. SAEON has a license to issue Digital Object Identifiers via DataCite on behalf of third parties, and have recently concluded development work to make a universal data deposit, description, and DOI minting facility available. This facility will be used to develop a number of end user gateways, including DataCite South Africa (in collaboration with National Research Foundation and addressing all grant-funded research in the country), DIRISA (Data-intensive Research Infrastructure for South Africa - in collaboration with Meraka Institute and Department of Science and Technology), and SASDI (South African Spatial Data Infrastructure). The RDA recently published Data Citation Recommendations [1], and this was used as a basis for specification of Digital Object Identifier implementation, raising two significant challenges: 1. Synchronisation of frequently harvested meta-data sets where version management practice did not align with the RDA recommendations, and 2. Handling sub-sets of and queries on large, continuously updated data sets. In the first case, we have developed a set of tests that determine the logical course of action when discrepancies are found during synchronization, and we have incorporated these into meta-data harvester configurations. Additionally, we have developed a state diagram and attendant workflow for meta-data that includes problem states emanating from DOI management, reporting services for data depositors, and feedback to end users in respect of synchronisation issues. In the second case, in the absence of firm guidelines from DataCite, we are seeking community consensus and feedback on an approach that caches all queries performed and subsets derived from data, and provide these with anchor-style extensions linked to the dataset's original DOI. This allows extended DOIs to resolve to a meta-data page on which the cached data set is available as an anchored download link.All cached datasets are provided with checksum values to verify the contents against such copies as may exist. The paper reviews recent service-driven portal interface developments, both services and graphical user interfaces, including wizard-style, configurable applications for meta-data management and DOI minting, discovery, download, visualization, and reporting. It showcases examples of the two permanent identifier problem areas and how these were addressed. The paper concludes with contributions to open research questions, including (1) determining optimal meta-data granularity and (2) proposing an implementation guideline for extended DOIs. [1] A. Rauber, D. van Uytvanck, A. Asmi, S. Pröll, "Data Citation Recommendations", November 2015, RDA. https://rd-alliance.org/group/data-citation-wg/outcomes/data-citation-recommendation.htm

Interior's Climate Science Centers: Focus or Fail

NASA Astrophysics Data System (ADS)

Udall, B.

2012-12-01

After a whirlwind two years of impressive and critical infrastructure building, the Department of Interior's Climate Science Centers are now in a position to either succeed or fail. The CSCs have a number of difficult structural problems including too many constituencies relative to the available resources, an uneasy relationship among many of the constituencies including the DOI agencies themselves, a need to do science in a new, difficult and non-traditional way, and a short timeframe to produce useful products. The CSCs have built a broad and impressive network of scientists and stakeholders. These entities include science providers of the universities and the USGS, and decision makers from the states, tribes, DOI land managers and other federal agencies and NGOs. Rather than try to support all of these constituencies the CSCs would be better served by refocusing on a core mission of supporting DOI climate related decision making. The CSCs were designed to service the climate science needs of DOI agencies, many of which lost their scientific capabilities in the 1990s due to a well-intentioned but ultimately harmful re-organization at DOI involving the now defunct National Biological Survey. Many of these agencies would like to have their own scientists, have an uneasy relationship with the nominal DOI science provider, the USGS, and don't communicate effectively among themselves. The CSCs must not succumb to pursuing science in either the traditional mode of the USGS or in the traditional mode of the universities, or worse, both of them. These scientific partners will need to be flexible, learn how to collaborate and should expect to see fewer resources. Useful CSC processes and outputs should start with the recommendations of the 2009 NRC Report Informing Decisions in a Changing Climate: (1) begin with users' needs; (2) give priority to process over products; (3) link information producers and users; (4) build connections across disciplines and organizations; (5) seek institutional stability; and (6) design processes for learning. In addition, CSC outputs should help decision makers to embrace and focus on uncertainty rather than on attempts to reduce uncertainty. Model building can be a useful exercise if used as a broad intellectual exercise to understand systems instead of narrow projection-based efforts. In some cases DOI agencies may want very simple products including scientific syntheses. Social science work including but not limited to economics and policy should be considered when appropriate to decision maker needs. One method for allocating CSC resources would involve a limited number of small scoping meetings with climate sensitive regional DOI agencies. In the Southwest, for example, regional entities would include at least the Landscape Conservation Cooperatives, National Park Service, Fish and Wildlife Service, Bureau of Land Management, Reclamation and the US Forest Service, a critically important land manager with a well-funded and well-structured climate program. Given DOI's trust responsibility to the tribes, at least one project should be focused on meeting those needs in this region. The goal of these meetings would be to identify a small number of projects each with adequate funding for interdisciplinary teams of university and USGS scientists and DOI decision makers. Done correctly, the CSCs should be able to leverage resources with these DOI partners.

Global assessment of river flood protection benefits and corresponding residual risks under climate change

NASA Astrophysics Data System (ADS)

Lim, Wee Ho; Yamazaki, Dai; Koirala, Sujan; Hirabayashi, Yukiko; Kanae, Shinjiro; Dadson, Simon J.; Hall, Jim W.

2016-04-01

Global warming increases the water-holding capacity of the atmosphere and this could lead to more intense rainfalls and possibly increasing natural hazards in the form of flooding in some regions. This implies that traditional practice of using historical hydrological records alone is somewhat limited for supporting long-term water infrastructure planning. This has motivated recent global scale studies to evaluate river flood risks (e.g., Hirabayashi et al., 2013, Arnell and Gosling, 2014, Sadoff et al., 2015) and adaptations benefits (e.g., Jongman et al., 2015). To support decision-making in river flood risk reduction, this study takes a further step to examine the benefits and corresponding residual risks for a range of flood protection levels. To do that, we channelled runoff information of a baseline period (forced by observed hydroclimate conditions) and each CMIP5 model (historic and future periods) into a global river routing model called CaMa-Flood (Yamazaki et al., 2011). We incorporated the latest global river width data (Yamazaki et al., 2014) into CaMa-Flood and simulate the river water depth at a spatial resolution of 15 min x 15 min. From the simulated results of baseline period, we use the annual maxima river water depth to fit the Gumbel distribution and prepare the return period-flood risk relationship (involving population and GDP). From the simulated results of CMIP5 model, we also used the annual maxima river water depth to obtain the Gumbel distribution and then estimate the exceedance probability (historic and future periods). We apply the return period-flood risk relationship (above) to the exceedance probability and evaluate the flood protection benefits. We quantify the corresponding residual risks using a mathematical approach that is consistent with the modelling structure of CaMa-Flood. Globally and regionally, we find that the benefits of flood protection level peak somewhere between 20 and 500 years; residual risks diminish substantially when flood protection level exceeds 20 years. These findings might be useful for decision-makers to weight the size of water infrastructure investment and emergency response capacity under climate change. References: Arnell, N.W, Gosling, S.N., 2014. The impact of climate change on river flood risk at the global scale. Climatic Change 122: 127-140, doi: 10.1007/s10584-014-1084-5. Hirabayashi et al., 2013. Global flood risk under climate change. Nature Climate Change 3: 816-821, doi: 10.1038/nclimate1911. Jongman et al., 2015. Declining vulnerability to river floods and the global benefits of adaptation. Proceedings of National Academy of the United States of America 112, E2271-E2280, doi: 10.1073/pnas.1414439112. Sadoff et al., 2015. Securing Water, Sustaining Growth: Report of the GWP/OECD Task Force on Water Security and Sustainable Growth, University of Oxford, UK, 180 pp. Yamazaki et al., 2011. A physically based description of floodplain inundation dynamics in a global river routing model. Water Resources Research 47, W04501, doi: 10.1029/2010wr009726. Yamazaki et al., 2014. Development of the Global Width Database for Large Rivers. Water Resources Research 50, 3467-3480, doi: 10.1002/2013WR014664.

High Order Accurate Algorithms for Shocks, Rapidly Changing Solutions and Multiscale Problems

DTIC Science & Technology

2014-11-13

for front propagation with obstacles, and homotopy method for steady states. Applications include high order simulations for 3D gaseous detonations ...obstacles, and homotopy method for steady states. Applications include high order simulations for 3D gaseous detonations , sound generation study via... detonation waves, Combustion and Flame, (02 2013): 0. doi: 10.1016/j.combustflame.2012.10.002 Yang Yang, Ishani Roy, Chi-Wang Shu, Li-Zhi Fang. THE

Processing-microstructure relationships in thermotropic liquid crystalline polymers: Experimental and numerical modeling studies

NASA Astrophysics Data System (ADS)

Fang, Jun

Thermotropic liquid crystalline polymers (TLCPs) are a class of promising engineering materials for high-demanding structural applications. Their excellent mechanical properties are highly correlated to the underlying molecular orientation states, which may be affected by complex flow fields during melt processing. Thus, understanding and eventually predicting how processing flows impact molecular orientation is a critical step towards rational design work in order to achieve favorable, balanced physical properties in finished products. This thesis aims to develop deeper understanding of orientation development in commercial TLCPs during processing by coordinating extensive experimental measurements with numerical computations. In situ measurements of orientation development of LCPs during processing are a focal point of this thesis. An x-ray capable injection molding apparatus is enhanced and utilized for time-resolved measurements of orientation development in multiple commercial TLCPs during injection molding. Ex situ wide angle x-ray scattering is also employed for more thorough characterization of molecular orientation distributions in molded plaques. Incompletely injection molded plaques ("short shots") are studied to gain further insights into the intermediate orientation states during mold filling. Finally, two surface orientation characterization techniques, near edge x-ray absorption fine structure (NEXAFS) and infrared attenuated total reflectance (FTIR-ATR) are combined to investigate the surface orientation distribution of injection molded plaques. Surface orientation states are found to be vastly different from their bulk counterparts due to different kinematics involved in mold filling. In general, complex distributions of orientation in molded plaques reflect the spatially varying competition between shear and extension during mold filling. To complement these experimental measurements, numerical calculations based on the Larson-Doi polydomain model are performed. The implementation of the Larson-Doi in complex processing flows is performed using a commercial process modeling software suite (MOLDFLOWRTM), exploiting a nearly exact analogy between the Larson-Doi model and a fiber orientation model that has been widely used in composites processing simulations. The modeling scheme is first verified by predicting many qualitative and quantitative features of molecular orientation distributions in isothermal extrusion-fed channel flows. In coordination with experiments, the model predictions are found to capture many qualitative features observed in injection molded plaques (including short shots). The final, stringent test of Larson-Doi model performance is prediction of in situ transient orientation data collected during mold filling. The model yields satisfactory results, though certain numerical approximations limit performance near the mold front.

30 CFR 1229.2 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Policy. 1229.2 Section 1229.2 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE DELEGATION TO STATES General Provisions § 1229.2 Policy. It shall be the policy of the Department of the Interior (DOI...

30 CFR 1228.2 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 3 2014-07-01 2014-07-01 false Policy. 1228.2 Section 1228.2 Mineral Resources OFFICE OF NATURAL RESOURCES REVENUE, DEPARTMENT OF THE INTERIOR NATURAL RESOURCES REVENUE COOPERATIVE ACTIVITIES WITH STATES AND INDIAN TRIBES General Provisions § 1228.2 Policy. It shall be the policy of DOI to...

30 CFR 229.2 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Policy. 229.2 Section 229.2 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT DELEGATION TO STATES General Provisions § 229.2 Policy. It shall be the policy of the Department of the Interior (DOI) to honor...

30 CFR 228.2 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Policy. 228.2 Section 228.2 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT COOPERATIVE ACTIVITIES WITH STATES AND INDIAN TRIBES General Provisions § 228.2 Policy. It shall be the policy of DOI to enter...

A flood map based DOI decoding method for block detector: a GATE simulation study.

PubMed

Shi, Han; Du, Dong; Su, Zhihong; Peng, Qiyu

2014-01-01

Positron Emission Tomography (PET) systems using detectors with Depth of Interaction (DOI) capabilities could achieve higher spatial resolution and better image quality than those without DOI. Up till now, most DOI methods developed are not cost-efficient for a whole body PET system. In this paper, we present a DOI decoding method based on flood map for low-cost conventional block detector with four-PMT readout. Using this method, the DOI information can be directly extracted from the DOI-related crystal spot deformation in the flood map. GATE simulations are then carried out to validate the method, confirming a DOI sorting accuracy of 85.27%. Therefore, we conclude that this method has the potential to be applied in conventional detectors to achieve a reasonable DOI measurement without dramatically increasing their complexity and cost of an entire PET system.

Choice of crystal surface finishing for a dual-ended readout depth-of-interaction (DOI) detector.

PubMed

Fan, Peng; Ma, Tianyu; Wei, Qingyang; Yao, Rutao; Liu, Yaqiang; Wang, Shi

2016-02-07

The objective of this study was to choose the crystal surface finishing for a dual-ended readout (DER) DOI detector. Through Monte Carlo simulations and experimental studies, we evaluated 4 crystal surface finishing options as combinations of crystal surface polishing (diffuse or specular) and reflector (diffuse or specular) options on a DER detector. We also tested one linear and one logarithm DOI calculation algorithm. The figures of merit used were DOI resolution, DOI positioning error, and energy resolution. Both the simulation and experimental results show that (1) choosing a diffuse type in either surface polishing or reflector would improve DOI resolution but degrade energy resolution; (2) crystal surface finishing with a diffuse polishing combined with a specular reflector appears a favorable candidate with a good balance of DOI and energy resolution; and (3) the linear and logarithm DOI calculation algorithms show overall comparable DOI error, and the linear algorithm was better for photon interactions near the ends of the crystal while the logarithm algorithm was better near the center. These results provide useful guidance in DER DOI detector design in choosing the crystal surface finishing and DOI calculation methods.

pH Dependent Spin State Population and 19F NMR Chemical Shift via Remote Ligand Protonation in an Iron(II) Complex (Postprint)

DTIC Science & Technology

2017-12-11

AFRL-RX-WP-JA-2017-0501 pH- DEPENDENT SPIN STATE POPULATION AND 19F NMR CHEMICAL SHIFT VIA REMOTE LIGAND PROTONATION IN AN IRON(II...From - To) 16 November 2017 Interim 24 January 2014 – 16 October 2017 4. TITLE AND SUBTITLE PH- DEPENDENT SPIN STATE POPULATION AND 19F NMR CHEMICAL...dx.doi.org/10.1039/C7CC08099A 14. ABSTRACT (Maximum 200 words) An FeII complex that features a pH- dependent spin state population, by virtue of a

The metal-insulator triple point in vanadium dioxide

NASA Astrophysics Data System (ADS)

Cobden, David

2014-03-01

The metal-insulator transition (MIT) in vanadium dioxide is a candidate for optical and electrical switching applications. However, being a first-order solid-state phase transition makes it challenging to study reproducibly in any detail. The combination of the change in unit cell shape, symmetry reduction, long range of elastic distortion, and latent heat leads to domain structure, hysteresis, and cracking of even the highest quality samples. At the MIT two stable insulating phases (M1 and M2) occur in addition to the metallic phase (R), but their phase stability diagram was poorly known. To establish it precisely we studied single-crystal nanobeams of VO2 in a purpose-built nanomechanical strain apparatus. We were able to measure the transition temperature accurately to be 65.0 +- 0.1 oC, to determine the phase boundary slopes, and to detect the intermediate metastable triclinic (T) phase where it is metastable towards M2. We were surprised to find that the transition occurs precisely at the solid-state triple point of the metallic and two insulating phases, a fact that is not explained by existing theories. See J.H. Park et al, Nature 500, 431-4 (August 2013), doi:10.1038/nature12425. Supported by US Department of Energy, Office of Basic Energy Sciences, Division of Materials Science and Engineering, award DE-SC0002197.

Influence of intertrial interval on basal and drug-induced impulsive action in the 5-choice serial reaction time task: Effects of d-amphetamine and (±)-2,5-dimethoxy-4-iodoamphetamine (DOI).

PubMed

Fitzpatrick, Ciaràn M; Maric, Vojislav S; Bate, Simon T; Andreasen, Jesper T

2018-01-01

Impulsivity is a characteristic of a number of neuropsychiatric disorders such as attention-deficit/hyperactivity disorder. The 5-choice serial reaction time task (5-CSRTT) is a rodent paradigm extensively used to assess attention and impulsivity. Notably, 5-CSRTT studies do not typically account for the reduction in premature responding, the measure of impulsive action, occurring upon repeated exposure to test sessions with long or variable intertrial intervals (ITIs). This present 5-CSRTT study investigated the use of variable ITIs (5, 10 or 15s) across 15 test days (4 training days followed by 1 drug test day per week for three weeks) as previous experience had shown that 4 training days would be sufficient to induce consistent premature response levels in male C57BL/6J mice. Once a steady state was achieved, the effects of dextroamphetamine (AMPH) and (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) were then assessed using a Latin-square design to determine whether pharmacological-induced impulsive actions depended on ITI length. Mice habituated to the variable ITI schedule after only 3days and showed consistently lower premature response levels until the end of the study. AMPH (p<0.05) and DOI (p<0.05) increased the percentage of premature responses at 15s ITI trials, while only DOI (p<0.05) increased impulsive action at 10s ITI trials. Additionally, DOI increased omission rates (p<0.001), mean correct latency (p<0.01), reward collection latency (p<0.001), and reduced the total attempted trials (p<0.001). In summary, we demonstrated that mice habituate to the variable ITI schedule, suggesting that using the variable ITI schedule during training allowed premature response rates to stabilize before commencing pharmacological testing. Moreover, in these habituated mice AMPH and DOI significantly enhanced impulsive action at the long ITI trials only. We propose that experimental design considerations can improve the sensitivity of the 5-CSRTT to detect pharmacologicallyinduced impulsive action. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluating excited state atomic polarizabilities of chromophores† †Electronic supplementary information (ESI) available: Basis set dependence, definition of bond charges, Romberg differentiation, python script to calculate atomic polarizabilities, influence of the cavity radius, atomic polarizabilities of coumarin 153, all tables in atomic units. See DOI: 10.1039/c7cp08549d

PubMed Central

Heid, Esther

2018-01-01

Ground and excited state dipoles and polarizabilities of the chromophores N-methyl-6-oxyquinolinium betaine (MQ) and coumarin 153 (C153) in solution have been evaluated using time-dependent density functional theory (TD-DFT). A method for determining the atomic polarizabilities has been developed; the molecular dipole has been decomposed into atomic charge transfer and polarizability terms, and variation in the presence of an electric field has been used to evaluate atomic polarizabilities. On excitation, MQ undergoes very site-specific changes in polarizability while C153 shows significantly less variation. We also conclude that MQ cannot be adequately described by standard atomic polarizabilities based on atomic number and hybridization state. Changes in the molecular polarizability of MQ (on excitation) are not representative of the local site-specific changes in atomic polarizability, thus the overall molecular polarizability ratio does not provide a good approximation for local atom-specific polarizability changes on excitation. Accurate excited state force fields are needed for computer simulation of solvation dynamics. The chromophores considered in this study are often used as molecular probes. The methods and data reported here can be used for the construction of polarizable ground and excited state force fields. Atomic and molecular polarizabilities (ground and excited states) have been evaluated over a range of functionals and basis sets. Different mechanisms for including solvation effects have been examined; using a polarizable continuum model, explicit solvation and via sampling of clusters extracted from a MD simulation. A range of different solvents have also been considered. PMID:29542743

Building Ecological and Community Resilience and Measuring Success of the Department of Interior Hurricane Sandy Resilience Projects

NASA Astrophysics Data System (ADS)

Taylor, S. M.; Worman, S. L.; Bennett, R.; Bassow, A.

2017-12-01

The Department of the Interior (DOI) partnered with the National Fish and Wildlife Foundation (NFWF) to administer an external funding competition to support coastal resilience projects in the region affected by Hurricane Sandy. The projects complement the DOI Bureau-led projects, but are led by state and local governments, universities, non-profits, community groups, tribes, and other non-Federal entities. In total, the Hurricane Sandy Resilience Program invested over $750 million in approximately 180 projects to repair damage and improve the resilience of habitats, communities and infrastructure to future storms and sea level rise. Project activities include waterway connection and opening, living shoreline, marsh restoration, community resilience planning, data/mapping/modeling, and beach and dune restoration. DOI and NFWF initiated a resilience assessment in 2015 to evaluate the impact of this investment. The assessment began by clarifying the program's resilience goals and the development of ecological and socio-economic metrics across the project activities. Using these metrics, the evaluation is assessing the ecological and community outcomes, cost effectiveness of activities, improved scientific understanding, and temporal and spatial scaling of benefits across resilience activities. Recognizing the unique opportunity afforded by the scale and distribution of projects, NFWF and DOI have invested in monitoring through 2024 to better understand how these projects perform over time. This presentation will describe the evaluation questions, approach, long-term monitoring, online metrics portal, and findings to date.

The National Climate Change and Wildlife Science Center annual report for 2012

USGS Publications Warehouse

Varela-Acevedo, Elda; O'Malley, Robin

2013-01-01

Welcome to the inaugural edition of the U.S. Geological Survey (USGS) National Climate Change and Wildlife Science Center (NCCWSC) and the Department of the Interior (DOI) Climate Science Centers (CSCs) annual report. In 2008, Congress created the National Climate Change and Wildlife Science Center (NCCWSC) within the U.S. Geological Survey (USGS). The center was formed to respond to the demands of natural resource managers for rigorous scientific information and effective tools for assessing and responding to climate change. Located at the USGS National Headquarters in Reston, Va., the NCCWSC has invested more than $70 million in cutting-edge climate change research and, in response to Secretarial Order No. 3289,established and is managing eight regional Department of Interior (DOI) Climate Science Centers (CSCs). The mission of the NCCWSC is to provide natural resource managers with the tools and information they need to develop and execute management strategies that address the impacts of climate and other ongoing global changes on fish and wildlife and their habitats. The DOI CSCs are joint Federal-university partnerships that focus their scientific work on regional priorities identified by DOI Landscape Conservation Cooperatives (LCCs) as well as Federal, State, Tribal, and other resource managers. The CSCs provide access to a wide range of scientific capabilities through their network of university partners along with the USGS and other Federal agency scientists. The focus of the NCCWSC on multiregion and national priorities complements the regionally focused agendas of the CSCs.

Evolution of DOI Usage and Registration

NASA Astrophysics Data System (ADS)

James, N.; Wanchoo, L.

2017-12-01

NASA's Earth Science Data and Information System (ESDIS) Project has implemented an automated system for assigning Digital Object Identifiers (DOIs) to Earth Science data products being managed by its network of 12 distributed active archive centers (DAACs). Using the ESDIS DOI system, over 3000 DOIs have been assigned, registered, and made publicly accessible while over 1000 assigned DOIs are being held in reserve until ready for public use. The goal is to assign a DOI to each of the 8000+ data collections under ESDIS management. DOIs make it easier for researchers to discover and use earth science data and they enable users to provide valid citations for the data they use in research. Also for the researcher wishing to reproduce the results presented in science publications, the DOI can be used to locate the exact data or data products being cited. ESDIS DOIs also provide data "Provenance" which is information about the creation and history of the data in question. This would include when the data was collected, which instrument was used to collect the data, and the version of the product at the time the DOI was assigned. Over the past few years, requests for DOIs have increased significantly as DAACs assign DOIs to both legacy data from earlier missions and new data products from in-orbit missions. This study will evaluate the evolution of DOI registration and its usage over those years comparing data products as they are organized by mission, science discipline and data product level. It is hoped that the study results will help NASA determine how to prioritize future products for DOI assignment and inform future studies that would identify trends over time of increased use of data citations resulting in increased discovery and distribution of NASA Earth science data products.

Magic informationally complete POVMs with permutations

NASA Astrophysics Data System (ADS)

Planat, Michel; Gedik, Zafer

2017-09-01

Eigenstates of permutation gates are either stabilizer states (for gates in the Pauli group) or magic states, thus allowing universal quantum computation (Planat, Rukhsan-Ul-Haq 2017 Adv. Math. Phys. 2017, 5287862 (doi:10.1155/2017/5287862)). We show in this paper that a subset of such magic states, when acting on the generalized Pauli group, define (asymmetric) informationally complete POVMs. Such informationally complete POVMs, investigated in dimensions 2-12, exhibit simple finite geometries in their projector products and, for dimensions 4 and 8 and 9, relate to two-qubit, three-qubit and two-qutrit contextuality.

Stratigraphical evidence of late Amazonian periglaciation and glaciation in the Astapus Colles region of Mars

NASA Astrophysics Data System (ADS)

Soare, Richard J.; Osinski, Gordon R.

2009-07-01

Recent modeling of the meteorological conditions during and following times of high obliquity suggests that an icy mantle could have been emplaced in western Utopia Planitia by atmospheric deposition during the late Amazonian period [Costard, F.M., Forget, F., Madeleine, J.B., Soare, R.J., Kargel, J.S., 2008. Lunar Planet. Sci. 39. Abstract 1274; Madeleine, B., Forget, F., Head, J.W., Levrard, B., Montmessin, F., 2007. Lunar Planet. Sci. 38. Abstract 1778]. Astapus Colles (ABa) is a late Amazonian geological unit - located in this hypothesized area of accumulation - that comprises an icy mantle tens of meters thick [Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888]. For the most part, this unit drapes the early Amazonian Vastitas Borealis interior unit (ABvi); to a lesser degree it overlies the early Amazonian Vastitas Borealis marginal unit (ABvm) and the early to late Hesperian UP plains unit HBu2 [Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888]. Landscapes possibly modified by late-Amazonian periglacial processes [Costard, F.M., Kargel, J.S., 1995. Icarus 114, 93-112; McBride, S.A., Allen, C.C., Bell, M.S., 2005. Lunar Planet. Sci. 36. Abstract 1090; Morgenstern, A., Hauber, E., Reiss, D., van Gasselt, S., Grosse, G., Schirrmeister, L., 2007. J. Geophys. Res. 112, doi:10.1029/2006JE002869. E06010; Seibert, N.M., Kargel, J.S., 2001. Geophys. Res. Lett. 28, 899-902; Soare, R.J., Kargel, J.S., Osinski, G.R., Costard, F., 2007. Icarus 191, 95-112; Soare, R.J., Osinski, G.R., Roehm, C.L., 2008. Earth Planet. Sci. Lett. 272, 382-393] and glacial processes [Milliken, R.E., Mustard, J.F., Goldsby, D.L., 2003. J. Geophys. Res. 108 (E6), doi:10.1029/2002JE002005. 5057; Mustard, J.F., Cooper, C.D., Rifkin, M.K., 2001. Nature 412, 411-414; Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888] have been reported within the region. Researchers have assumed that the periglacial and glacial landscapes occur within the same geological unit, the ABa [i.e., Morgenstern, A., Hauber, E., Reiss, D., van Gasselt, S., Grosse, G., Schirrmeister, L., 2007. J. Geophys. Res. 112; doi:10.1029/2006JE002869. E06010; Tanaka, K.L., Skinner, J.A., Hare, T.M., 2005. US Geol. Surv. Sci. Invest., Map 2888]. In this study we use HiRISE (High Resolution Image Science Experiment, Mars Reconnaissance Orbiter) imagery to identify the stratigraphical separation of the two landscapes and show that periglacial landscape modification has occurred in the geological units that underlie the ABa, not in the ABa itself. Moreover, we suggest that the periglacial landscape extends well beyond the perimeter of the ABa and could be the product of "wet" cold-climate processes. These processes involve freeze-thaw cycles and intermittently stable liquid-water at or near the surface. By contrast, we propose that the ABa is a very recent late-Amazonian geological unit formed principally by "dry" cold-climate processes. These processes comprise accumulation (by atmospheric deposition) and ablation (by sublimation).

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

PubMed Central

Isaac, R Stefan; Jiang, Fuguo; Doudna, Jennifer A; Lim, Wendell A; Narlikar, Geeta J; Almeida, Ricardo

2016-01-01

The CRISPR-Cas9 bacterial surveillance system has become a versatile tool for genome editing and gene regulation in eukaryotic cells, yet how CRISPR-Cas9 contends with the barriers presented by eukaryotic chromatin is poorly understood. Here we investigate how the smallest unit of chromatin, a nucleosome, constrains the activity of the CRISPR-Cas9 system. We find that nucleosomes assembled on native DNA sequences are permissive to Cas9 action. However, the accessibility of nucleosomal DNA to Cas9 is variable over several orders of magnitude depending on dynamic properties of the DNA sequence and the distance of the PAM site from the nucleosome dyad. We further find that chromatin remodeling enzymes stimulate Cas9 activity on nucleosomal templates. Our findings imply that the spontaneous breathing of nucleosomal DNA together with the action of chromatin remodelers allow Cas9 to effectively act on chromatin in vivo. DOI: http://dx.doi.org/10.7554/eLife.13450.001 PMID:27130520

Cohabiting family members share microbiota with one another and with their dogs.

PubMed

Song, Se Jin; Lauber, Christian; Costello, Elizabeth K; Lozupone, Catherine A; Humphrey, Gregory; Berg-Lyons, Donna; Caporaso, J Gregory; Knights, Dan; Clemente, Jose C; Nakielny, Sara; Gordon, Jeffrey I; Fierer, Noah; Knight, Rob

2013-04-16

Human-associated microbial communities vary across individuals: possible contributing factors include (genetic) relatedness, diet, and age. However, our surroundings, including individuals with whom we interact, also likely shape our microbial communities. To quantify this microbial exchange, we surveyed fecal, oral, and skin microbiota from 60 families (spousal units with children, dogs, both, or neither). Household members, particularly couples, shared more of their microbiota than individuals from different households, with stronger effects of co-habitation on skin than oral or fecal microbiota. Dog ownership significantly increased the shared skin microbiota in cohabiting adults, and dog-owning adults shared more 'skin' microbiota with their own dogs than with other dogs. Although the degree to which these shared microbes have a true niche on the human body, vs transient detection after direct contact, is unknown, these results suggest that direct and frequent contact with our cohabitants may significantly shape the composition of our microbial communities. DOI:http://dx.doi.org/10.7554/eLife.00458.001.

Cohabiting family members share microbiota with one another and with their dogs

PubMed Central

Song, Se Jin; Lauber, Christian; Costello, Elizabeth K; Lozupone, Catherine A; Humphrey, Gregory; Berg-Lyons, Donna; Caporaso, J Gregory; Knights, Dan; Clemente, Jose C; Nakielny, Sara; Gordon, Jeffrey I; Fierer, Noah; Knight, Rob

2013-01-01

Human-associated microbial communities vary across individuals: possible contributing factors include (genetic) relatedness, diet, and age. However, our surroundings, including individuals with whom we interact, also likely shape our microbial communities. To quantify this microbial exchange, we surveyed fecal, oral, and skin microbiota from 60 families (spousal units with children, dogs, both, or neither). Household members, particularly couples, shared more of their microbiota than individuals from different households, with stronger effects of co-habitation on skin than oral or fecal microbiota. Dog ownership significantly increased the shared skin microbiota in cohabiting adults, and dog-owning adults shared more ‘skin’ microbiota with their own dogs than with other dogs. Although the degree to which these shared microbes have a true niche on the human body, vs transient detection after direct contact, is unknown, these results suggest that direct and frequent contact with our cohabitants may significantly shape the composition of our microbial communities. DOI: http://dx.doi.org/10.7554/eLife.00458.001 PMID:23599893

Onboard photo: Astronauts at work

NASA Technical Reports Server (NTRS)

1997-01-01

Onboard Space Shuttle Columbia's (STS-87) first ever Extravehicular Activity (EVA), astronaut Takao Doi works with a 156-pound crane carried onboard for the first time. The crane's inclusion and the work with it are part of a continuing preparation effort for future work on the International Space Station (ISS). The ongoing project allows for evaluation of tools and operating methods to be applied to the construction of the Space Station. This crane device is designed to aid future space walkers in transporting Orbital Replacement Units (ORU), with a mass up to 600 pounds (like the simulated battery pictured here), from translating carts on the exterior of ISS to various worksites on the truss structure. Earlier Doi, an international mission specialist representing Japan, and astronaut Winston E. Scott, mission specialist, had installed the crane in a socket along the middle port side of Columbia's cargo bay for the evaluation. The two began the crane operations after completing a contingency EVA to snag the free-flying Spartan 201 and berth it in the payload bay (visible in the background).

Space Shuttle Project

NASA Image and Video Library

1997-11-19

Onboard Space Shuttle Columbia's (STS-87) first ever Extravehicular Activity (EVA), astronaut Takao Doi works with a 156-pound crane carried onboard for the first time. The crane's inclusion and the work with it are part of a continuing preparation effort for future work on the International Space Station (ISS). The ongoing project allows for evaluation of tools and operating methods to be applied to the construction of the Space Station. This crane device is designed to aid future space walkers in transporting Orbital Replacement Units (ORU), with a mass up to 600 pounds (like the simulated battery pictured here), from translating carts on the exterior of ISS to various worksites on the truss structure. Earlier Doi, an international mission specialist representing Japan, and astronaut Winston E. Scott, mission specialist, had installed the crane in a socket along the middle port side of Columbia's cargo bay for the evaluation. The two began the crane operations after completing a contingency EVA to snag the free-flying Spartan 201 and berth it in the payload bay (visible in the background).

α/β coiled coils

PubMed Central

Hartmann, Marcus D; Mendler, Claudia T; Bassler, Jens; Karamichali, Ioanna; Ridderbusch, Oswin; Lupas, Andrei N; Hernandez Alvarez, Birte

2016-01-01

Coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. This level of understanding has allowed their manipulation in unprecedented detail. They do not seem a likely source of surprises, yet we describe here the unexpected formation of a new type of fiber by the simple insertion of two or six residues into the underlying heptad repeat of a parallel, trimeric coiled coil. These insertions strain the supercoil to the breaking point, causing the local formation of short β-strands, which move the path of the chain by 120° around the trimer axis. The result is an α/β coiled coil, which retains only one backbone hydrogen bond per repeat unit from the parent coiled coil. Our results show that a substantially novel backbone structure is possible within the allowed regions of the Ramachandran space with only minor mutations to a known fold. DOI: http://dx.doi.org/10.7554/eLife.11861.001 PMID:26771248

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

PubMed Central

Freire-Pritchett, Paula; Schoenfelder, Stefan; Várnai, Csilla; Wingett, Steven W; Cairns, Jonathan; Collier, Amanda J; García-Vílchez, Raquel; Furlan-Magaril, Mayra; Osborne, Cameron S; Fraser, Peter; Rugg-Gunn, Peter J; Spivakov, Mikhail

2017-01-01

Long-range cis-regulatory elements such as enhancers coordinate cell-specific transcriptional programmes by engaging in DNA looping interactions with target promoters. Deciphering the interplay between the promoter connectivity and activity of cis-regulatory elements during lineage commitment is crucial for understanding developmental transcriptional control. Here, we use Promoter Capture Hi-C to generate a high-resolution atlas of chromosomal interactions involving ~22,000 gene promoters in human pluripotent and lineage-committed cells, identifying putative target genes for known and predicted enhancer elements. We reveal extensive dynamics of cis-regulatory contacts upon lineage commitment, including the acquisition and loss of promoter interactions. This spatial rewiring occurs preferentially with predicted changes in the activity of cis-regulatory elements and is associated with changes in target gene expression. Our results provide a global and integrated view of promoter interactome dynamics during lineage commitment of human pluripotent cells. DOI: http://dx.doi.org/10.7554/eLife.21926.001 PMID:28332981

Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system

PubMed Central

Bush, Nicholas E; Schroeder, Christopher L; Hobbs, Jennifer A; Yang, Anne ET; Huet, Lucie A; Solla, Sara A; Hartmann, Mitra JZ

2016-01-01

Tactile information available to the rat vibrissal system begins as external forces that cause whisker deformations, which in turn excite mechanoreceptors in the follicle. Despite the fundamental mechanical origin of tactile information, primary sensory neurons in the trigeminal ganglion (Vg) have often been described as encoding the kinematics (geometry) of object contact. Here we aimed to determine the extent to which Vg neurons encode the kinematics vs. mechanics of contact. We used models of whisker bending to quantify mechanical signals (forces and moments) at the whisker base while simultaneously monitoring whisker kinematics and recording single Vg units in both anesthetized rats and awake, body restrained rats. We employed a novel manual stimulation technique to deflect whiskers in a way that decouples kinematics from mechanics, and used Generalized Linear Models (GLMs) to show that Vg neurons more directly encode mechanical signals when the whisker is deflected in this decoupled stimulus space. DOI: http://dx.doi.org/10.7554/eLife.13969.001 PMID:27348221

Texture coarseness responsive neurons and their mapping in layer 2–3 of the rat barrel cortex in vivo

PubMed Central

Garion, Liora; Dubin, Uri; Rubin, Yoav; Khateb, Mohamed; Schiller, Yitzhak; Azouz, Rony; Schiller, Jackie

2014-01-01

Texture discrimination is a fundamental function of somatosensory systems, yet the manner by which texture is coded and spatially represented in the barrel cortex are largely unknown. Using in vivo two-photon calcium imaging in the rat barrel cortex during artificial whisking against different surface coarseness or controlled passive whisker vibrations simulating different coarseness, we show that layer 2–3 neurons within barrel boundaries differentially respond to specific texture coarsenesses, while only a minority of neurons responded monotonically with increased or decreased surface coarseness. Neurons with similar preferred texture coarseness were spatially clustered. Multi-contact single unit recordings showed a vertical columnar organization of texture coarseness preference in layer 2–3. These findings indicate that layer 2–3 neurons perform high hierarchical processing of tactile information, with surface coarseness embodied by distinct neuronal subpopulations that are spatially mapped onto the barrel cortex. DOI: http://dx.doi.org/10.7554/eLife.03405.001 PMID:25233151

Associative learning changes cross-modal representations in the gustatory cortex

PubMed Central

Vincis, Roberto; Fontanini, Alfredo

2016-01-01

A growing body of literature has demonstrated that primary sensory cortices are not exclusively unimodal, but can respond to stimuli of different sensory modalities. However, several questions concerning the neural representation of cross-modal stimuli remain open. Indeed, it is poorly understood if cross-modal stimuli evoke unique or overlapping representations in a primary sensory cortex and whether learning can modulate these representations. Here we recorded single unit responses to auditory, visual, somatosensory, and olfactory stimuli in the gustatory cortex (GC) of alert rats before and after associative learning. We found that, in untrained rats, the majority of GC neurons were modulated by a single modality. Upon learning, both prevalence of cross-modal responsive neurons and their breadth of tuning increased, leading to a greater overlap of representations. Altogether, our results show that the gustatory cortex represents cross-modal stimuli according to their sensory identity, and that learning changes the overlap of cross-modal representations. DOI: http://dx.doi.org/10.7554/eLife.16420.001 PMID:27572258

The genome and phenome of the green alga Chloroidium sp. UTEX 3007 reveal adaptive traits for desert acclimatization

PubMed Central

Nelson, David R; Khraiwesh, Basel; Fu, Weiqi; Alseekh, Saleh; Jaiswal, Ashish; Chaiboonchoe, Amphun; Hazzouri, Khaled M; O’Connor, Matthew J; Butterfoss, Glenn L; Drou, Nizar; Rowe, Jillian D; Harb, Jamil; Fernie, Alisdair R; Gunsalus, Kristin C; Salehi-Ashtiani, Kourosh

2017-01-01

To investigate the phenomic and genomic traits that allow green algae to survive in deserts, we characterized a ubiquitous species, Chloroidium sp. UTEX 3007, which we isolated from multiple locations in the United Arab Emirates (UAE). Metabolomic analyses of Chloroidium sp. UTEX 3007 indicated that the alga accumulates a broad range of carbon sources, including several desiccation tolerance-promoting sugars and unusually large stores of palmitate. Growth assays revealed capacities to grow in salinities from zero to 60 g/L and to grow heterotrophically on >40 distinct carbon sources. Assembly and annotation of genomic reads yielded a 52.5 Mbp genome with 8153 functionally annotated genes. Comparison with other sequenced green algae revealed unique protein families involved in osmotic stress tolerance and saccharide metabolism that support phenomic studies. Our results reveal the robust and flexible biology utilized by a green alga to successfully inhabit a desert coastline. DOI: http://dx.doi.org/10.7554/eLife.25783.001 PMID:28623667

Learning shapes the aversion and reward responses of lateral habenula neurons

PubMed Central

Wang, Daqing; Li, Yi; Feng, Qiru; Guo, Qingchun; Zhou, Jingfeng; Luo, Minmin

2017-01-01

The lateral habenula (LHb) is believed to encode negative motivational values. It remains unknown how LHb neurons respond to various stressors and how learning shapes their responses. Here, we used fiber-photometry and electrophysiology to track LHb neuronal activity in freely-behaving mice. Bitterness, pain, and social attack by aggressors intensively excite LHb neurons. Aversive Pavlovian conditioning induced activation by the aversion-predicting cue in a few trials. The experience of social defeat also conditioned excitatory responses to previously neutral social stimuli. In contrast, fiber photometry and single-unit recordings revealed that sucrose reward inhibited LHb neurons and often produced excitatory rebound. It required prolonged conditioning and high reward probability to induce inhibition by reward-predicting cues. Therefore, LHb neurons can bidirectionally process a diverse array of aversive and reward signals. Importantly, their responses are dynamically shaped by learning, suggesting that the LHb participates in experience-dependent selection of behavioral responses to stressors and rewards. DOI: http://dx.doi.org/10.7554/eLife.23045.001 PMID:28561735

The neuronal architecture of the mushroom body provides a logic for associative learning

PubMed Central

Aso, Yoshinori; Hattori, Daisuke; Yu, Yang; Johnston, Rebecca M; Iyer, Nirmala A; Ngo, Teri-TB; Dionne, Heather; Abbott, LF; Axel, Richard; Tanimoto, Hiromu; Rubin, Gerald M

2014-01-01

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell–MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory. DOI: http://dx.doi.org/10.7554/eLife.04577.001 PMID:25535793

A connectome of a learning and memory center in the adult Drosophila brain

PubMed Central

Takemura, Shin-ya; Aso, Yoshinori; Hige, Toshihide; Wong, Allan; Lu, Zhiyuan; Xu, C Shan; Rivlin, Patricia K; Hess, Harald; Zhao, Ting; Parag, Toufiq; Berg, Stuart; Huang, Gary; Katz, William; Olbris, Donald J; Plaza, Stephen; Umayam, Lowell; Aniceto, Roxanne; Chang, Lei-Ann; Lauchie, Shirley; Ogundeyi, Omotara; Ordish, Christopher; Shinomiya, Aya; Sigmund, Christopher; Takemura, Satoko; Tran, Julie; Turner, Glenn C; Rubin, Gerald M; Scheffer, Louis K

2017-01-01

Understanding memory formation, storage and retrieval requires knowledge of the underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of associative learning. We reconstructed the morphologies and synaptic connections of all 983 neurons within the three functional units, or compartments, that compose the adult MB’s α lobe, using a dataset of isotropic 8 nm voxels collected by focused ion-beam milling scanning electron microscopy. We found that Kenyon cells (KCs), whose sparse activity encodes sensory information, each make multiple en passant synapses to MB output neurons (MBONs) in each compartment. Some MBONs have inputs from all KCs, while others differentially sample sensory modalities. Only 6% of KC>MBON synapses receive a direct synapse from a dopaminergic neuron (DAN). We identified two unanticipated classes of synapses, KC>DAN and DAN>MBON. DAN activation produces a slow depolarization of the MBON in these DAN>MBON synapses and can weaken memory recall. DOI: http://dx.doi.org/10.7554/eLife.26975.001 PMID:28718765

Theoretical Study of Solid State Quantum Information Processing

DTIC Science & Technology

2013-08-28

0. doi: 10.1103/PhysRevB.86.035302 08/31/2012 22.00 Yu-xi Liu, Franco Nori, Xuedong Hu. Strong coupling of a spin qubit to a superconducting ...applications to current EDSR experiments on nanowire QDs, g-factor optimization of confined electrons, and spin decay measurements in DQD spin-orbit qubits ...program is to provide theoretical support to the study of solid state quantum computing, with a focus on spin qubits . Our main research thrusts have been

Temporal Changes in Rat Liver Gene Expression after Acute Cadmium and Chromium Exposure

DTIC Science & Technology

2015-05-19

William E. Dennis3, Valerie C. Minarchick4, Stephen S. Leonard4, David A. Jackson3, Jonathan D. Stallings3, John A. Lewis3* 1 ORISE Postdoctoral Fellow...pharmaceutical, industrial processes or environmental contamination. Cr is extensively used for stainless steel production, PLOSONE | DOI:10.1371/journal.pone...Michael Madejczyk; Christine Baer; William Dennis; Valerie Minarchick; Stephen Leonard 5d. PROJECT NUMBER 5e. TASK NUMBER X1 5f. WORK UNIT NUMBER

Colistin Pharmacokinetics in Burn Patients During Continuous Venovenous Hemofiltration

DTIC Science & Technology

2015-01-01

NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION...Materials. All drugs and chemicals were reagent grade and were obtained from Sigma (St. Louis, MO) unless otherwise noted. Pharmacokinetic sampling...Chemother 50: 1953 –1958. http://dx.doi.org/10.1128/AAC .00035-06. 4. Zavascki AP. 2014. Polymyxins for the treatment of extensively-drug- resistant Gram

Identifying resource manager information needs for the North Pacific Landscape Conservation Cooperative

USGS Publications Warehouse

Woodward, Andrea; Liedtke, Theresa; Jenni, Karen

2014-01-01

Landscape Conservation Cooperatives (LCCs) are a network of 22 public-private partnerships, defined by ecoregion, that share and provide science to ensure the sustainability of land, water, wildlife and cultural resources in North America. LLCs were established by the U.S. Department of Interior (DOI) in recognition that response to climate change must be coordinated on a landscape-level basis because important resources, ecosystem processes and resource management challenges extend beyond national wildlife refuges, Bureau of Land Management lands, national parks, and even international boundaries. Therefore, DOI agencies must work with other Federal, State, Tribal (U.S. indigenous peoples), First Nation (Canadian indigenous peoples), and local governments, as well as private landowners, to develop landscape-level strategies for understanding and responding to climate change.

Isolation of 2-deoxy-scyllo-inosose (DOI)-assimilating yeasts and cloning and characterization of the DOI reductase gene of Cryptococcus podzolicus ND1.

PubMed

Ara, Satoshi; Yamazaki, Harutake; Takaku, Hiroaki

2018-04-01

2-Deoxy-scyllo-inosose (DOI) is the first intermediate in the 2-deoxystreptamine-containing aminoglycoside antibiotic biosynthesis pathway and has a six-membered carbocycle structure. DOI is a valuable material because it is easily converted to aromatic compounds and carbasugar derivatives. In this study, we isolated yeast strains capable of assimilating DOI as a carbon source. One of the strains, Cryptococcus podzolicus ND1, mainly converted DOI to scyllo-quercitol and (-)-vibo-quercitol, which is a valuable compound used as an antihypoglycemia agent and as a heat storage material. An NADH-dependent DOI reductase coding gene, DOIR, from C. podzolicus ND1 was cloned and successfully overexpressed in Escherichia coli. The purified protein catalyzed the irreversible reduction of DOI with NADH and converted DOI into (-)-vibo-quercitol. The enzyme had an optimal pH of 8.5 and optimal temperature of 35°C, respectively. The k cat of this enzyme was 9.98 s -1 , and the K m values for DOI and NADH were 4.38 and 0.24 mM, respectively. The enzyme showed a strong preference for NADH and showed no activity with NADPH. Multiple-alignment analysis of DOI reductase revealed that it belongs to the GFO_IDH_MocA protein family and is an inositol dehydrogenase homolog in other fungi, such as Cryptococcus gattii, and bacteria, such as Bacillus subtilis. This is the first identification of a DOI-assimilating yeast and a gene involved in DOI metabolism in fungi. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Application of Earthquake Subspace Detectors at Kilauea and Mauna Loa Volcanoes, Hawai`i

NASA Astrophysics Data System (ADS)

Okubo, P.; Benz, H.; Yeck, W.

2016-12-01

Recent studies have demonstrated the capabilities of earthquake subspace detectors for detailed cataloging and tracking of seismicity in a number of regions and settings. We are exploring the application of subspace detectors at the United States Geological Survey's Hawaiian Volcano Observatory (HVO) to analyze seismicity at Kilauea and Mauna Loa volcanoes. Elevated levels of microseismicity and occasional swarms of earthquakes associated with active volcanism here present cataloging challenges due the sheer numbers of earthquakes and an intrinsically low signal-to-noise environment featuring oceanic microseism and volcanic tremor in the ambient seismic background. With high-quality continuous recording of seismic data at HVO, we apply subspace detectors (Harris and Dodge, 2011, Bull. Seismol. Soc. Am., doi: 10.1785/0120100103) during intervals of noteworthy seismicity. Waveform templates are drawn from Magnitude 2 and larger earthquakes within clusters of earthquakes cataloged in the HVO seismic database. At Kilauea, we focus on seismic swarms in the summit caldera region where, despite continuing eruptions from vents in the summit region and in the east rift zone, geodetic measurements reflect a relatively inflated volcanic state. We also focus on seismicity beneath and adjacent to Mauna Loa's summit caldera that appears to be associated with geodetic expressions of gradual volcanic inflation, and where precursory seismicity clustered prior to both Mauna Loa's most recent eruptions in 1975 and 1984. We recover several times more earthquakes with the subspace detectors - down to roughly 2 magnitude units below the templates, based on relative amplitudes - compared to the numbers of cataloged earthquakes. The increased numbers of detected earthquakes in these clusters, and the ability to associate and locate them, allow us to infer details of the spatial and temporal distributions and possible variations in stresses within these key regions of the volcanoes.

Utilization of Physical Therapy Intervention Among Patients With Plantar Fasciitis in the United States.

PubMed

Fraser, John J; Glaviano, Neal R; Hertel, Jay

2017-02-01

Study Design Retrospective observational study. Background Plantar fasciitis is responsible for 1 million ambulatory patient care visits annually in the United States. Few studies have investigated practice patterns in the treatment of patients with plantar fasciitis. Objective To assess physical therapist utilization and employment of manual therapy and supervised rehabilitation in the treatment of patients with plantar fasciitis. Methods A retrospective review of the PearlDiver patient record database was used to evaluate physical therapist utilization and use of manual therapy and supervised rehabilitation in patients with plantar fasciitis between 2007 and 2011. An International Classification of Diseases code (728.71) was used to identify plantar fasciitis, and Current Procedural Terminology codes were used to identify evaluations (97001), manual therapy (97140), and rehabilitation services (97110, 97530, 97112). Results A total of 819 963 unique patients diagnosed with plantar fasciitis accounted for 5 739 737 visits from 2007 to 2011, comprising 2.7% of all patients in the database. Only 7.1% (95% confidence interval: 7.0%, 7.1%) of patients received a physical therapist evaluation. Of the 57 800 patients evaluated by a physical therapist (59.8% female), 50 382 (87.2% ± 0.4%) received manual therapy, with significant increases in utilization per annum. A large proportion (89.5% ± 0.4%) received rehabilitation following physical therapist evaluation. Conclusion Despite plantar fasciitis being a frequently occurring musculoskeletal condition, a small proportion of patients with plantar fasciitis were seen by physical therapists. Most patients who were evaluated by a physical therapist received manual therapy and a course of supervised rehabilitation as part of their plan of care. Level of Evidence Treatment, level 2a. J Orthop Sports Phys Ther 2017;47(2):49-55. doi:10.2519/jospt.2017.6999.

Estimating the Number of Low-Income Americans Exposed to Household Air Pollution from Burning Solid Fuels

PubMed Central

Rogalsky, Derek K.; Mendola, Pauline; Metts, Tricia A.

2014-01-01

Background: Exposure to household air pollution (HAP) from inefficient biomass and coal stoves kills nearly 4 million people every year worldwide. HAP is an environmental risk associated with poverty that affects an estimated 3 billion people mostly in low- and middle-income countries. Objectives: Our goal was to estimate the number of low-income Americans exposed to potentially health-damaging concentrations of HAP. Methods: We mapped county-level data for the percentage of households using wood, coal, and/or coke as their primary heating fuel along with percent of the population below the federal poverty level. Using U.S. Census data and the likelihood of fugitive emissions as reported in the literature, we estimated the number of low-income Americans potentially exposed to HAP. Results: Solid fuel is the primary heating source for > 2.5 million U.S. households, or 6.5 million people. The mapping exercise showed several rural areas, primarily in the northern and western regions, that have high levels of solid-fuel use and poverty. We then identified 117 counties with high co-incident poverty and solid-fuel use as high-priority counties for research into potential health risks from HAP. We estimate that between 500,000 and 600,000 low-income people in the United States are likely exposed to HAP from burning solid fuels within their homes. Conclusion: HAP occurs within the United States and should be further investigated for adverse health risks, especially among those living in areas with rural poverty. Citation: Rogalsky DK, Mendola P, Metts TA, Martin WJ II. 2014. Estimating the number of low-income Americans exposed to household air pollution from burning solid fuels. Environ Health Perspect 122:806–810; http://dx.doi.org/10.1289/ehp.1306709 PMID:24833615

Hawaii Gravity Model

DOE Data Explorer

Nicole Lautze

2015-12-15

Gravity model for the state of Hawaii. Data is from the following source: Flinders, A.F., Ito, G., Garcia, M.O., Sinton, J.M., Kauahikaua, J.P., and Taylor, B., 2013, Intrusive dike complexes, cumulate cores, and the extrusive growth of Hawaiian volcanoes: Geophysical Research Letters, v. 40, p. 3367–3373, doi:10.1002/grl.50633.

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

PubMed Central

Nikolić, Marko Z; Caritg, Oriol; Jeng, Quitz; Johnson, Jo-Anne; Sun, Dawei; Howell, Kate J; Brady, Jane L; Laresgoiti, Usua; Allen, George; Butler, Richard; Zilbauer, Matthias; Giangreco, Adam; Rawlins, Emma L

2017-01-01

The embryonic mouse lung is a widely used substitute for human lung development. For example, attempts to differentiate human pluripotent stem cells to lung epithelium rely on passing through progenitor states that have only been described in mouse. The tip epithelium of the branching mouse lung is a multipotent progenitor pool that self-renews and produces differentiating descendants. We hypothesized that the human distal tip epithelium is an analogous progenitor population and tested this by examining morphology, gene expression and in vitro self-renewal and differentiation capacity of human tips. These experiments confirm that human and mouse tips are analogous and identify signalling pathways that are sufficient for long-term self-renewal of human tips as differentiation-competent organoids. Moreover, we identify mouse-human differences, including markers that define progenitor states and signalling requirements for long-term self-renewal. Our organoid system provides a genetically-tractable tool that will allow these human-specific features of lung development to be investigated. DOI: http://dx.doi.org/10.7554/eLife.26575.001 PMID:28665271

The selectivity of the Na+/K+-pump is controlled by binding site protonation and self-correcting occlusion

PubMed Central

Rui, Huan; Artigas, Pablo; Roux, Benoît

2016-01-01

The Na+/K+-pump maintains the physiological K+ and Na+ electrochemical gradients across the cell membrane. It operates via an 'alternating-access' mechanism, making iterative transitions between inward-facing (E1) and outward-facing (E2) conformations. Although the general features of the transport cycle are known, the detailed physicochemical factors governing the binding site selectivity remain mysterious. Free energy molecular dynamics simulations show that the ion binding sites switch their binding specificity in E1 and E2. This is accompanied by small structural arrangements and changes in protonation states of the coordinating residues. Additional computations on structural models of the intermediate states along the conformational transition pathway reveal that the free energy barrier toward the occlusion step is considerably increased when the wrong type of ion is loaded into the binding pocket, prohibiting the pump cycle from proceeding forward. This self-correcting mechanism strengthens the overall transport selectivity and protects the stoichiometry of the pump cycle. DOI: http://dx.doi.org/10.7554/eLife.16616.001 PMID:27490484

Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

PubMed Central

Habermacher, Chloé; Martz, Adeline; Calimet, Nicolas; Lemoine, Damien; Peverini, Laurie; Specht, Alexandre; Cecchini, Marco; Grutter, Thomas

2016-01-01

P2X receptors function by opening a transmembrane pore in response to extracellular ATP. Recent crystal structures solved in apo and ATP-bound states revealed molecular motions of the extracellular domain following agonist binding. However, the mechanism of pore opening still remains controversial. Here we use photo-switchable cross-linkers as ‘molecular tweezers’ to monitor a series of inter-residue distances in the transmembrane domain of the P2X2 receptor during activation. These experimentally based structural constraints combined with computational studies provide high-resolution models of the channel in the open and closed states. We show that the extent of the outer pore expansion is significantly reduced compared to the ATP-bound structure. Our data further reveal that the inner and outer ends of adjacent pore-lining helices come closer during opening, likely through a hinge-bending motion. These results provide new insight into the gating mechanism of P2X receptors and establish a versatile strategy applicable to other membrane proteins. DOI: http://dx.doi.org/10.7554/eLife.11050.001 PMID:26808983

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

PubMed Central

Alamo, Lorenzo; Ware, James S; Pinto, Antonio; Gillilan, Richard E; Seidman, Jonathan G; Seidman, Christine E; Padrón, Raúl

2017-01-01

Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent relaxation and energetic deficits that characterize HCM. During relaxation, pairs of myosins form interacting-heads motif (IHM) structures that with other sarcomere proteins establish an energy-saving, super-relaxed (SRX) state. Using a human β-cardiac myosin IHM quasi-atomic model, we defined interactions sites between adjacent myosin heads and associated protein partners, and then analyzed rare variants from 6112 HCM and 1315 DCM patients and 33,370 ExAC controls. HCM variants, 72% that changed electrostatic charges, disproportionately altered IHM interaction residues (expected 23%; HCM 54%, p=2.6×10−19; DCM 26%, p=0.66; controls 20%, p=0.23). HCM variant locations predict impaired IHM formation and stability, and attenuation of the SRX state - accounting for altered contractility, reduced diastolic relaxation, and increased energy consumption, that fully characterizes HCM pathogenesis. DOI: http://dx.doi.org/10.7554/eLife.24634.001 PMID:28606303

Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite

PubMed Central

Clingman, Carina C; Deveau, Laura M; Hay, Samantha A; Genga, Ryan M; Shandilya, Shivender MD; Massi, Francesca; Ryder, Sean P

2014-01-01

Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for their function. Pluripotent stem cells have the ability to differentiate into a wide variety of specialized cells. How metabolic state contributes to stem cell differentiation is not understood. In this study, we show that RNA-binding by the stem cell translation regulator Musashi-1 (MSI1) is allosterically inhibited by 18–22 carbon ω-9 monounsaturated fatty acids. The fatty acid binds to the N-terminal RNA Recognition Motif (RRM) and induces a conformational change that prevents RNA association. Musashi proteins are critical for development of the brain, blood, and epithelium. We identify stearoyl-CoA desaturase-1 as a MSI1 target, revealing a feedback loop between ω-9 fatty acid biosynthesis and MSI1 activity. We propose that other RRM proteins could act as metabolite sensors to couple gene expression changes to physiological state. DOI: http://dx.doi.org/10.7554/eLife.02848.001 PMID:24935936

Erratum.

PubMed

2015-04-01

In issue 21.1 three of the DOIs were printed incorrectly, please see below for the correct information. Andrea Giorgianni, et al. Flow-diverter stenting of post-traumatic bilateral anterior cerebral artery pseudoaneurysm: A case report. Doi: 10.15274/INR-2014-10059 Correct: Doi: 10.1177/1591019915575441 Lee-Anne Slater, et al. Effect of flow diversion with silk on aneurysm size: A single center experience. Doi: 10.15274/INR-2014-10062 Correct DOI: 10.1177/1591019915576433 Robert J McDonald, et al. Periprocedural safety of Pipeline therapy for unruptured cerebral aneurysms: Analysis of 279 Patients in a multihospital database. Doi: 10.15274/INR-2014-10074 Correct DOI: 10.1177/1591019915576289. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

The Soil Series in Soil Classifications of the United States

NASA Astrophysics Data System (ADS)

Indorante, Samuel; Beaudette, Dylan; Brevik, Eric C.

2014-05-01

Organized national soil survey began in the United States in 1899, with soil types as the units being mapped. The soil series concept was introduced into the U.S. soil survey in 1903 as a way to relate soils being mapped in one area to the soils of other areas. The original concept of a soil series was all soil types formed in the same parent materials that were of the same geologic age. However, within about 15 years soil series became the primary units being mapped in U.S. soil survey. Soil types became subdivisions of soil series, with the subdivisions based on changes in texture. As the soil series became the primary mapping unit the concept of what a soil series was also changed. Instead of being based on parent materials and geologic age, the soil series of the 1920s was based on the morphology and composition of the soil profile. Another major change in the concept of soil series occurred when U.S. Soil Taxonomy was released in 1975. Under Soil Taxonomy, the soil series subdivisions were based on the uses the soils might be put to, particularly their agricultural uses (Simonson, 1997). While the concept of the soil series has changed over the years, the term soil series has been the longest-lived term in U.S. soil classification. It has appeared in every official classification system used by the U.S. soil survey (Brevik and Hartemink, 2013). The first classification system was put together by Milton Whitney in 1909 and had soil series at its second lowest level, with soil type at the lowest level. The second classification system used by the U.S. soil survey was developed by C.F. Marbut, H.H. Bennett, J.E. Lapham, and M.H. Lapham in 1913. It had soil series at the second highest level, with soil classes and soil types at more detailed levels. This was followed by another system in 1938 developed by M. Baldwin, C.E. Kellogg, and J. Thorp. In this system soil series were again at the second lowest level with soil types at the lowest level. The soil type concept was dropped and replaced by the soil phase in the 1950s in a modification of the 1938 Baldwin et al. classification (Simonson, 1997). When Soil Taxonomy was released in 1975, soil series became the most detailed (lowest) level of the classification system, and the only term maintained throughout all U.S. classifications to date. While the number of recognized soil series have increased steadily throughout the history of U.S. soil survey, there was a rapid increase in the recognition of new soil series following the introduction of Soil Taxonomy (Brevik and Hartemink, 2013). References Brevik, E.C., and A.E. Hartemink. 2013. Soil maps of the United States of America. Soil Science Society of America Journal 77:1117-1132. doi:10.2136/sssaj2012.0390. Simonson, R.W. 1997. Evolution of soil series and type concepts in the United States. Advances in Geoecology 29:79-108.

Structure and formation of highly luminescent protein-stabilized gold clusters† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc05086k

PubMed Central

Chevrier, D. M.; Thanthirige, V. D.; Luo, Z.; Driscoll, S.; Cho, P.; MacDonald, M. A.; Yao, Q.; Guda, R.; Xie, J.; Johnson, E. R.; Chatt, A.; Zheng, N.

2018-01-01

Highly luminescent gold clusters simultaneously synthesized and stabilized by protein molecules represent a remarkable category of nanoscale materials with promising applications in bionanotechnology as sensors. Nevertheless, the atomic structure and luminescence mechanism of these gold clusters are still unknown after several years of developments. Herein, we report findings on the structure, luminescence and biomolecular self-assembly of gold clusters stabilized by the large globular protein, bovine serum albumin. We highlight the surprising identification of interlocked gold-thiolate rings as the main gold structural unit. Importantly, such gold clusters are in a rigidified state within the protein scaffold, offering an explanation for their highly luminescent character. Combined free-standing cluster synthesis (without protecting protein scaffold) with rigidifying and un-rigidifying experiments, were designed to further verify the luminescence mechanism and gold atomic structure within the protein. Finally, the biomolecular self-assembly process of the protein-stabilized gold clusters was elucidated by time-dependent X-ray absorption spectroscopy measurements and density functional theory calculations. PMID:29732064

Perylene bisimide hydrogels and lyotropic liquid crystals with temperature-responsive color change† †Electronic supplementary information (ESI) available: Detailed procedures and results for all reported experiments, along with synthetic details for PBI 1. See DOI: 10.1039/c6sc02249a Click here for additional data file.

PubMed Central

Görl, Daniel; Soberats, Bartolome; Herbst, Stefanie; Stepanenko, Vladimir

2016-01-01

The self-assembly of perylene bisimide (PBI) dyes bearing oligo ethylene glycol (OEG) units in water affords responsive functional nanostructures characterized by their lower critical solution temperature (LCST). Tuning of the LCST is realized by a supramolecular approach that relies on two structurally closely related PBI–OEG molecules. The two PBIs socially co-assemble in water and the resulting nanostructures exhibit a single LCST in between the transition temperatures of the aggregates formed by single components. This permits to precisely tune the transition from a hydrogel to a lyotropic liquid crystal state at temperatures between 26 and 51 °C by adjusting the molar fraction of the two PBIs. Owing to concomitant changes in PBI–PBI interactions this phase transition affords a pronounced color change with “fluorescence-on” response that can be utilized as a smart temperature sensory system. PMID:28451124

Draft genome and sequence variant data of the oomycete Pythium insidiosum strain Pi45 from the phylogenetically-distinct Clade-III.

PubMed

Kittichotirat, Weerayuth; Patumcharoenpol, Preecha; Rujirawat, Thidarat; Lohnoo, Tassanee; Yingyong, Wanta; Krajaejun, Theerapong

2017-12-01

Pythium insidiosum is a unique oomycete microorganism, capable of infecting humans and animals. The organism can be phylogenetically categorized into three distinct clades: Clade-I (strains from the Americas); Clade-II (strains from Asia and Australia), and Clade-III (strains from Thailand and the United States). Two draft genomes of the P. insidiosum Clade-I strain CDC-B5653 and Clade-II strain Pi-S are available in the public domain. The genome of P. insidiosum from the distinct Clade-III, which is distantly-related to the other two clades, is lacking. Here, we report the draft genome sequence of the P. insidiosum strain Pi45 (also known as MCC13; isolated from a Thai patient with pythiosis; accession numbers BCFM01000001-BCFM01017277) as a representative strain of the phylogenetically-distinct Clade-III. We also report a genome-scale data set of sequence variants (i.e., SNPs and INDELs) found in P. insidiosum (accessible online at the Mendeley database: http://dx.doi.org/10.17632/r75799jy6c.1).

USA National Phenology Network observational data documentation

USGS Publications Warehouse

Rosemartin, Alyssa H.; Denny, Ellen G.; Gerst, Katharine L.; Marsh, R. Lee; Posthumus, Erin E.; Crimmins, Theresa M.; Weltzin, Jake F.

2018-04-25

The goals of the USA National Phenology Network (USA-NPN, www.usanpn.org) are to advance science, inform decisions, and communicate and connect with the public regarding phenology and species’ responses to environmental variation and climate change. The USA-NPN seeks to advance the science of phenology and facilitate ecosystem stewardship by providing phenological information freely and openly. To accomplish these goals, the USA-NPN National Coordinating Office (NCO) delivers observational data on plant and animal phenology in several formats, including minimally processed status and intensity datasets and derived phenometrics for individual plants, sites, and regions. This document describes the suite of observational data products delivered by the USA National Phenology Network, covering the period 2009–present for the United States and accessible via the Phenology Observation Portal (http://dx.doi.org/10.5066/F78S4N1V) and via an Application Programming Interface. The data described here have been used in diverse research and management applications, including over 30 publications in fields such as remote sensing, plant evolution, and resource management.

STS-87 Payload Specialist Leonid Kadenyuk chats with NASA Administrator Daniel Goldin shortly after

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine (NSAU), at left, chats with NASA Administrator Daniel Goldin shortly after the landing of Columbia at Kennedy Space Center. Looking on is back-up Payload Specialist Yaroslav Pustovyi, also of NSAU. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, at KSC's Shuttle Landing Facility Runway 33, drawing the 15-day, 16-hour and 34- minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Commander Kevin Kregel; Pilot Steven Lindsey; and Mission Specialists Winston Scott, Kalpana Chawla, Ph.D., and Takao Doi, Ph.D., of the National Space Development Agency of Japan. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

Research Spotlight: The varying life expectancies of American reservoirs

NASA Astrophysics Data System (ADS)

Schultz, Colin

2011-04-01

Tasked with controlling floods, coping through droughts, generating electricity, maintaining the flow of drinking water, preserving species' habitats, and managing the local environment, the United States' large-scale freshwater management system is important. Unfortunately, as sediment is washed from river basins to reservoirs, the persistent addition of material eats away at a reservoir's capacity and, consequently, its useful life expectancy. Understanding the integrity of the reservoir system is particularly important, with climate projections anticipating warmer, drier conditions for some parts of the country. Using a database of sedimentation surveys conducted between 1775 and 1993, Graf et al. calculate the life expectancies of many of the nation's reservoirs. They find that although most of the country's large reservoirs were built between 1950 and 1960, they have a wide range of expiration dates. They find that most large reservoirs, those with capacities greater than 1.2 cubic kilometers (0.29 cubic mile), have useful life expectancies ranging from 200 to more than 1000 years, with the lowest average life expectancy in the interior West. (Water Resources Research, doi:10.1029/2009WR008836, 2010)

Assessing carbon stocks, carbon sequestration, and greenhouse-gas fluxes in ecosystems of the United States under present conditions and future scenarios

USGS Publications Warehouse

Zhu, Zhi-Liang; Stackpoole, Sarah

2011-01-01

The Energy Independence and Security Act of 2007 (EISA) requires the U.S. Department of the Interior (DOI) to develop a methodology and conduct an assessment of carbon storage, carbon sequestration, and greenhouse-gas (GHG) fluxes in the Nation's ecosystems. The U.S. Geological Survey (USGS) has developed and published the methodology (U.S. Geological Survey Scientific Investigations Report 2010-5233) and has assembled an interdisciplinary team of scientists to conduct the assessment over the next three to four years, commencing in October 2010. The assessment will fulfill specific requirements of the EISA by (1) quantifying, measuring, and monitoring carbon sequestration and GHG fluxes using national datasets and science tools such as remote sensing, and biogeochemical and hydrological models, (2) evaluating a range of management and restoration activities for their effects on carbon-sequestration capacity and the reduction of GHG fluxes, and (3) assessing effects of climate change and other controlling processes (including wildland fires) on carbon uptake and GHG emissions from ecosystems.

Reliability beyond Theory and into Practice

ERIC Educational Resources Information Center

Sijtsma, Klaas

2009-01-01

The critical reactions of Bentler (2009, doi: 10.1007/s11336-008-9100-1), Green and Yang (2009a, doi: 10.1007/s11336-008-9098-4 ; 2009b, doi: 10.1007/s11336-008-9099-3), and Revelle and Zinbarg (2009, doi: 10.1007/s11336-008-9102-z) to Sijtsma's (2009, doi: 10.1007/s11336-008-9101-0) paper on Cronbach's alpha are addressed. The dissemination of…

Link-Prediction Enhanced Consensus Clustering for Complex Networks (Open Access)

DTIC Science & Technology

2016-05-20

92:022816. Available from: http://link.aps.org/doi/10.1103/PhysRevE.92.022816. doi: 10. 1103 /PhysRevE.92.022816 16. Aldecoa R, Marín I. Exploring the...from: http://link.aps.org/doi/10.1103/PhysRevE.80.056117. doi: 10. 1103 /PhysRevE.80.056117 18. Dahlin J, Svenson P. Ensemble approaches for improving...046110. Available from: http://link.aps.org/doi/10.1103/PhysRevE.81.046110. doi: 10. 1103 /PhysRevE.81.046110 28. Gfeller D, Chappelier JC, De Los Rios P

The representation of non-equilibrium soil types in earth system models and its impact on carbon cycle projections

NASA Astrophysics Data System (ADS)

Hugelius, G.; Ahlström, A.; Canadell, J.; Koven, C. D.; Jackson, R. B.; Luo, Y.

2016-12-01

Soils hold the largest reactive pool of carbon (C) on earth. Global soil organic C stocks (0-200 cm depth plus full peatland depth) are estimated to 2200 Pg C (adapted from Hugelius et al., 2014, Köchy et al., 2015 and Batjes, 2016). Soil C stocks in Earth system models (ESMs) can be generated by running the model over a longer time period until soil C pools are in or near steady-state. Inherent in this concept is the idea that soil C stocks are in (quasi)equilibrium as determined by the balance of net ecosystem input to soil organic matter and its turnover. The rate of turnover is sometimes subdivided into several pools and the rates are affected by various environmental factors. Here we break down the empirically based estimates of global soil C pools into equilibrium-type soils which current (Coupled Model Intercomparison Project, phase 5; CMIP5) generation ESMs are set-up to represent and non-equilibrium type soils which are generally not represented in current ESMs. We define equilibrium soils as those where pedogenesis (and associated soil C formation) is not significantly limited by the environmental factors perennial soil freezing, waterlogging/anoxia or limited unconsolidated soil substrate. This is essentially all permafrost-free mineral soils that are not in a wetland or alpine setting. On the other hand, non-equlibrium soils are defined as permafrost soils, peatlands and alpine soils with a limited fine-soil matrix. Based on geospatial analyses of state-of-the-art datasets on soil C stocks, we estimate that the global soil C pool is divided roughly equally between equilibrium and non-equlibrium type soils. We discuss the ways in which this result affects C cycling in ESMs and projections of soil C sensitivity under a changing climate. ReferencesBatjes N.H. (2016) Geoderma, 269, 61-68, doi: 10.1016/j.geoderma.2016.01.034 Hugelius G. et al. (2014) Biogeosciences, 11, 6573-6593, doi:10.5194/bg-11-6573-2014 Köchy M. et al. (2015) Soil 1, 351-365. DOI: doi:10.5194/soil-1-351-2015

Early detection of consciousness in patients with acute severe traumatic brain injury.

PubMed

Edlow, Brian L; Chatelle, Camille; Spencer, Camille A; Chu, Catherine J; Bodien, Yelena G; O'Connor, Kathryn L; Hirschberg, Ronald E; Hochberg, Leigh R; Giacino, Joseph T; Rosenthal, Eric S; Wu, Ona

2017-09-01

See Schiff (doi:10.1093/awx209) for a scientific commentary on this article. Patients with acute severe traumatic brain injury may recover consciousness before self-expression. Without behavioural evidence of consciousness at the bedside, clinicians may render an inaccurate prognosis, increasing the likelihood of withholding life-sustaining therapies or denying rehabilitative services. Task-based functional magnetic resonance imaging and electroencephalography techniques have revealed covert consciousness in the chronic setting, but these techniques have not been tested in the intensive care unit. We prospectively enrolled 16 patients admitted to the intensive care unit for acute severe traumatic brain injury to test two hypotheses: (i) in patients who lack behavioural evidence of language expression and comprehension, functional magnetic resonance imaging and electroencephalography detect command-following during a motor imagery task (i.e. cognitive motor dissociation) and association cortex responses during language and music stimuli (i.e. higher-order cortex motor dissociation); and (ii) early responses to these paradigms are associated with better 6-month outcomes on the Glasgow Outcome Scale-Extended. Patients underwent functional magnetic resonance imaging on post-injury Day 9.2 ± 5.0 and electroencephalography on Day 9.8 ± 4.6. At the time of imaging, behavioural evaluation with the Coma Recovery Scale-Revised indicated coma (n = 2), vegetative state (n = 3), minimally conscious state without language (n = 3), minimally conscious state with language (n = 4) or post-traumatic confusional state (n = 4). Cognitive motor dissociation was identified in four patients, including three whose behavioural diagnosis suggested a vegetative state. Higher-order cortex motor dissociation was identified in two additional patients. Complete absence of responses to language, music and motor imagery was only observed in coma patients. In patients with behavioural evidence of language function, responses to language and music were more frequently observed than responses to motor imagery (62.5-80% versus 33.3-42.9%). Similarly, in 16 matched healthy subjects, responses to language and music were more frequently observed than responses to motor imagery (87.5-100% versus 68.8-75.0%). Except for one patient who died in the intensive care unit, all patients with cognitive motor dissociation and higher-order cortex motor dissociation recovered beyond a confusional state by 6 months. However, 6-month outcomes were not associated with early functional magnetic resonance imaging and electroencephalography responses for the entire cohort. These observations suggest that functional magnetic resonance imaging and electroencephalography can detect command-following and higher-order cortical function in patients with acute severe traumatic brain injury. Early detection of covert consciousness and cortical responses in the intensive care unit could alter time-sensitive decisions about withholding life-sustaining therapies. © The Author (2017). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

On the timing of high-pressure metamorphism in Alpine Corsica: the first Lu-Hf garnet and lawsonite ages

NASA Astrophysics Data System (ADS)

Vitale Brovarone, A.; Herwartz, D.; Castelli, D.; Malavieille, J.

2012-04-01

Timing of HP metamorphism in Alpine Corsica is highly debated. Controversial biostratigraphic and radiometric constraints results in a poor understanding of the evolution of Alpine Corsica and its meaning in the Western Mediterranean dynamics. Age estimates provided by means of several techniques (e.g. Ar-Ar, Sa-Nd, U-Pb) vary form Late Cretaceous to Late Eocene. Some authors favor a Late Cretaceous peak metamorphism under HP conditions followed by Late Eocene and Early Oligocene blueschist and greenschist retrogression, respectively. Others favor a Late Eocene peak metamorphism and consider the older estimates as affected by analytical inaccuracy. In order to unravel this debate, we provide new Lu-Hf constraints on garnet and lawsonite from the lawsonite-eclogite and lawsonite-blueschist units of Alpine Corsica, which represent a part of the so-called Schistes Lustrés complex. The two investigated units are interpreted to represent remnants of the former Corsican ocean-continent transition zone [2]. As Lu concentrates in the cores of the selected minerals during the early stages of growth and blocking temperatures are high, this method provides robust insight on the timing of prograde/peak metamorphism [1]. Garnet and lawsonite separated form three lawsonite-eclogite samples yield systematic Late Eocene ages at ~ 34 Ma, while lawsonite from the lawsonite-blueschist unit yields a slightly older age at ~ 37 Ma. These data are in agreement with U-Pb data on zircon from the lawsonite-eclogite unit (~ 34 Ma) [3], but are in contrast with a recent U-Pb estimate on the Corsican continental margin unit metamorphosed under blueschist condition, yielding an age of ~ 55 Ma [4]. These discrepancies indicate a complex paleogeographic setting and a diachronous metamorphic evolution along the Corsican ocean-continent transition zone. The Late Eocene HP metamorphism in the Schistes Lustrés of Alpine Corsica also provides important constraints in the evolution of the Alps-Apennine system and the surrounding Western Mediterranean area. [1] Skora, S., Baumgartner, L.P., Mahlen, N.J., Lapen, T.J., Johnson, C.M., Bussy, F. 2008. Estimation of a maximum Lu diffusion rate in a natural eclogite garnet. Swiss J. Geosci. DOI: 10.1007/s00015-008-1268-y. [2] Vitale Brovarone, A., Beltrando, M., Malavieille, J., Giuntoli, F, Tondella, E, Groppo, C., Beyssac, O. and Compagnoni, R., 2011a. Inherited Ocean-Continent Transition zones in deeply subducted terranes: Insights from Alpine Corsica, Lithos, doi: 10.1016/j.lithos.2011.02.013. [3] Martin., L., Rubatto, D., Vitale Brovarone, A., Hermann, J. 2011. Late Eocene lawsonite-eclogite facies metasomatism of a granulite sliver associated to ophiolites in Alpine Corsica. Lithos, doi:10.1016/j.lithos.2011.03.015 [4] Maggi M, Rossetti F, Theye T, Andersen T, Corfu F, Faccenna C. Sodic Pyroxene Bearing Phyllonites From the East Tenda Shear Zone: Constraining P-T Conditions and Timing of the Ligurian-Piemontese Ocean Overthrusting Onto the Variscan Corsica. Abstract Corsealp 2011. Saint Florent, Corsica, France.

Bedrock geologic map of the Worcester South quadrangle, Worcester County, Massachusetts

USGS Publications Warehouse

Walsh, Gregory J.; Merschat, Arthur J.

2015-09-29

The bedrock geology was mapped to study the tectonic history of the area and to provide a framework for ongoing hydrogeologic characterization of the fractured bedrock of Massachusetts. This report presents mapping by Gregory J. Walsh and Arthur J. Merschat from 2008 to 2010. The report consists of a map and GIS database, both of which are available for download at http://dx.doi.org/ 10.3133/sim3345. The database includes contacts of bedrock geologic units, faults, outcrop locations, structural information, and photographs.

Further Development of a Model for Rod Ricochet

DTIC Science & Technology

2007-02-01

PROJECT NUMBER AH80 5e. TASK NUMBER 6. AUTHOR( S ) Steven B. Segletes 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES...164 10. SPONSOR/MONITOR’S ACRONYM( S ) 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES) 11. SPONSOR/MONITOR’S REPORT NUMBER( S ) 12...TELEPHONE NUMBER (Include area code) 410-306-1939 Standard Form 298 (Rev. 8/98) Prescribed by ANSI Std. Z39.18 ARTICLE IN PRESS0734-743X/$ - s doi

On the Hausdorff dimension faithfulness connected with Q_{\\infty} -expansion

NASA Astrophysics Data System (ADS)

Liu, Jia; Zhang, Zhenliang

2017-06-01

In this paper, we show that, the family of all possible unions of finitely many consecutive cylinders of the same rank of a Q∞ -expansion is faithful for the Hausdorff dimension calculations. Applying this result, we give a necessary and sufficient condition for the family of all cylinders of the Q∞ -expansion to be faithful for Hausdorff dimension calculation on the unit interval. This answers an open problem mentioned in Albeverio et al (2016 Math. Nachr. at press (https//:doi.org/10.1002/mana.201500471)).

44 CFR 206.348 - Consultation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... designated representative of the Department of the Interior (DOI) at the regional level before approving any.... (a) The consultation shall be by written memorandum to the DOI representative and shall contain the... understanding with DOI, the DOI representative will provide technical information and an opinion whether or not...

44 CFR 206.348 - Consultation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... designated representative of the Department of the Interior (DOI) at the regional level before approving any.... (a) The consultation shall be by written memorandum to the DOI representative and shall contain the... understanding with DOI, the DOI representative will provide technical information and an opinion whether or not...

Implementing DOIs for Oceanographic Satellite Data at PO.DAAC

NASA Astrophysics Data System (ADS)

Hausman, J.; Tauer, E.; Chung, N.; Chen, C.; Moroni, D. F.

2013-12-01

The Physical Oceanographic Distributed Active Archive Center (PO.DAAC) is NASA's archive for physical oceanographic satellite data. It distributes over 500 datasets from gravity, ocean wind, sea surface topography, sea ice, ocean currents, salinity, and sea surface temperature satellite missions. A dataset is a collection of granules/files that share the same mission/project, versioning, processing level, spatial, and temporal characteristics. The large number of datasets is partially due to the number of satellite missions, but mostly because a single satellite mission typically has multiple versions or even temporal and spatial resolutions of data. As a result, a user might mistake one dataset for a different dataset from the same satellite mission. Due to the PO.DAAC'S vast variety and volume of data and growing requirements to report dataset usage, it has begun implementing DOIs for the datasets it archives and distributes. However, this was not as simple as registering a name for a DOI and providing a URL. Before implementing DOIs multiple questions needed to be answered. What are the sponsor and end-user expectations regarding DOIs? At what level does a DOI get assigned (dataset, file/granule)? Do all data get a DOI, or only selected data? How do we create a DOI? How do we create landing pages and manage them? What changes need to be made to the data archive, life cycle policy and web portal to accommodate DOIs? What if the data also exists at another archive and a DOI already exists? How is a DOI included if the data were obtained via a subsetting tool? How does a researcher or author provide a unique, definitive reference (standard citation) for a given dataset? This presentation will discuss how these questions were answered through changes in policy, process, and system design. Implementing DOIs is not a trivial undertaking, but as DOIs are rapidly becoming the de facto approach, it is worth the effort. Researchers have historically referenced the source satellite and data center (or archive), but scientific writings do not typically provide enough detail to point to a singular, uniquely identifiable dataset. DOIs provide the means to help researchers be precise in their data citations and provide needed clarity, standardization and permanence.

Wikipedia as a gateway to biomedical research: The relative distribution and use of citations in the English Wikipedia.

PubMed

Maggio, Lauren A; Willinsky, John M; Steinberg, Ryan M; Mietchen, Daniel; Wass, Joseph L; Dong, Ting

2017-01-01

Wikipedia is a gateway to knowledge. However, the extent to which this gateway ends at Wikipedia or continues via supporting citations is unknown. Wikipedia's gateway functionality has implications for information design and education, notably in medicine. This study aims to establish benchmarks for the relative distribution and referral (click) rate of citations-as indicated by presence of a Digital Object Identifier (DOI)-from Wikipedia, with a focus on medical citations. DOIs referred from the English Wikipedia in August 2016 were obtained from Crossref.org. Next, based on a DOI's presence on a WikiProject Medicine page, all DOIs in Wikipedia were categorized as medical (WP:MED) or non-medical (non-WP:MED). Using this categorization, referred DOIs were classified as WP:MED, non-WP:MED, or BOTH, meaning the DOI may have been referred from either category. Data were analyzed using descriptive and inferential statistics. Out of 5.2 million Wikipedia pages, 4.42% (n = 229,857) included at least one DOI. 68,870 were identified as WP:MED, with 22.14% (n = 15,250) featuring one or more DOIs. WP:MED pages featured on average 8.88 DOI citations per page, whereas non-WP:MED pages had on average 4.28 DOI citations. For DOIs only on WP:MED pages, a DOI was referred every 2,283 pageviews and for non-WP:MED pages every 2,467 pageviews. DOIs from BOTH pages accounted for 12% (n = 58,475). The referral of DOI citations found in BOTH could not be assigned to WP:MED or non-WP:MED, as the page from which the referral was made was not provided with the data. While these results cannot provide evidence of greater citation referral from WP:MED than non-WP:MED, they do provide benchmarks to assess strategies for changing referral patterns. These changes might include editors adopting new methods for designing and presenting citations or the introduction of teaching strategies that address the value of consulting citations as a tool for extending learning.

The Ocean Carbon States Database: a proof-of-concept application of cluster analysis in the ocean carbon cycle

NASA Astrophysics Data System (ADS)

Latto, Rebecca; Romanou, Anastasia

2018-03-01

In this paper, we present a database of the basic regimes of the carbon cycle in the ocean, the ocean carbon states, as obtained using a data mining/pattern recognition technique in observation-based as well as model data. The goal of this study is to establish a new data analysis methodology, test it and assess its utility in providing more insights into the regional and temporal variability of the marine carbon cycle. This is important as advanced data mining techniques are becoming widely used in climate and Earth sciences and in particular in studies of the global carbon cycle, where the interaction of physical and biogeochemical drivers confounds our ability to accurately describe, understand, and predict CO2 concentrations and their changes in the major planetary carbon reservoirs. In this proof-of-concept study, we focus on using well-understood data that are based on observations, as well as model results from the NASA Goddard Institute for Space Studies (GISS) climate model. Our analysis shows that ocean carbon states are associated with the subtropical-subpolar gyre during the colder months of the year and the tropics during the warmer season in the North Atlantic basin. Conversely, in the Southern Ocean, the ocean carbon states can be associated with the subtropical and Antarctic convergence zones in the warmer season and the coastal Antarctic divergence zone in the colder season. With respect to model evaluation, we find that the GISS model reproduces the cold and warm season regimes more skillfully in the North Atlantic than in the Southern Ocean and matches the observed seasonality better than the spatial distribution of the regimes. Finally, the ocean carbon states provide useful information in the model error attribution. Model air-sea CO2 flux biases in the North Atlantic stem from wind speed and salinity biases in the subpolar region and nutrient and wind speed biases in the subtropics and tropics. Nutrient biases are shown to be most important in the Southern Ocean flux bias. All data and analysis scripts are available at https://data.giss.nasa.gov/oceans/carbonstates/ (DOI: https://doi.org/10.5281/zenodo.996891).

43 CFR 17.332 - Mediation.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and Enforcement Procedures § 17.332 Mediation. (a) Referral of complaints for mediation. DOI will... it. The FMCS shall send the agreement to DOI. DOI, however, retains the right to monitor the... process without prior approval of the head of the mediation agency. (e) DOI will use the mediation process...

Textbook and Instructional Materials Adoption Policy and Procedures. Policy Brief

ERIC Educational Resources Information Center

Dumas, Paul

2006-01-01

In the U.S.-affiliated Pacific, the U.S. Department of Education (U.S. ED) and the U.S. Department of the Interior (DOI) are responsible for assisting State educational agencies (SEAs) in the development of planning and accountability systems to meet the requirements of the "No Child Left Behind Act of 2001" (NCLB) requirements and…

Chemotherapy Necessitates Increased Immune Control of HHVs: A Cause of Persistent Inflammation Enabling Protracted Fatigue in Breast Cancer Survivors

DTIC Science & Technology

2015-06-01

Hypothesis: This work hypothesizes that chemotherapy can permanently alter the balance between the immune system and chronic herpesvirus ...States. PloS one 6, e16103, doi:10.1371/journal.pone.0016103 (2011). 3 Bennett, J. M. et al. Inflammation and reactivation of latent herpesviruses in

Effect of wall-mediated hydrodynamic fluctuations on the kinetics of a Brownian nanoparticle

NASA Astrophysics Data System (ADS)

Yu, Hsiu-Yu; Eckmann, David M.; Ayyaswamy, Portonovo S.; Radhakrishnan, Ravi

2016-12-01

The reactive flux formalism (Chandler 1978 J. Chem. Phys. 68, 2959-2970. (doi:10.1063/1.436049)) and the subsequent development of methods such as transition path sampling have laid the foundation for explicitly quantifying the rate process in terms of microscopic simulations. However, explicit methods to account for how the hydrodynamic correlations impact the transient reaction rate are missing in the colloidal literature. We show that the composite generalized Langevin equation (Yu et al. 2015 Phys. Rev. E 91, 052303. (doi:10.1103/PhysRevE.91.052303)) makes a significant step towards solving the coupled processes of molecular reactions and hydrodynamic relaxation by examining how the wall-mediated hydrodynamic memory impacts the two-stage temporal relaxation of the reaction rate for a nanoparticle transition between two bound states in the bulk, near-wall and lubrication regimes.

Measuring In-Plane Displacements with Variable Sensitivity Using Diffractive Optic Interferometry

NASA Technical Reports Server (NTRS)

Shepherd, Robert L.; Gilbert, John A.; Cole, Helen J.; Ashley, Paul R.

1998-01-01

This paper introduces a method called diffractive optic interferometry (DOI) which allows in-plane displacement components to be measured with variable sensitivity. DOI relies on binary optical elements fabricated as phase-type Dammann gratings which produce multiple diffraction orders of nearly equal intensity. Sensitivity is varied by combining the different wavefronts produced by a conjugate pair of these binary optical elements; a transmission element is used to produce several illumination beams while a reflective element, replicated on the surface of a specimen, provides the reference for the undeformed state. The steps taken to design and fabricate these binary optical elements are described. The specimen grating is characterized, and tested on a disk subjected to diametrical compression. Overall, the results are excellent, with experimental data agreeing to within a few percent of the theoretical predictions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

A hearing on the management of the Department of Interior's (DOI) Onshore Oil and Gas Leasing Program examined the question of geology versus market forces in determining lease boundaries and lease offerings. At issue was the question of possible fraud and the loss of revenue to states when leases are sold over the counter or by lottery, as described by Senator Dale Bumpers of Arkansas and the Governor of Wyoming, and the potential environmental damage that could result from an accelerated federal leasing program. Representatives of DOI described leasing procedures and efforts to balance the need for orderly exploration whilemore » also meeting economic and environmental goals. The witnesses also included representatives of environmental groups, geologists, and the oil and gas industry. An appendix with additional correspondence, statements, and other material submitted for the record follows the testimony of the 13 witnesses.« less

Software Uncertainty in Integrated Environmental Modelling: the role of Semantics and Open Science

NASA Astrophysics Data System (ADS)

de Rigo, Daniele

2013-04-01

Computational aspects increasingly shape environmental sciences [1]. Actually, transdisciplinary modelling of complex and uncertain environmental systems is challenging computational science (CS) and also the science-policy interface [2-7]. Large spatial-scale problems falling within this category - i.e. wide-scale transdisciplinary modelling for environment (WSTMe) [8-10] - often deal with factors (a) for which deep-uncertainty [2,11-13] may prevent usual statistical analysis of modelled quantities and need different ways for providing policy-making with science-based support. Here, practical recommendations are proposed for tempering a peculiar - not infrequently underestimated - source of uncertainty. Software errors in complex WSTMe may subtly affect the outcomes with possible consequences even on collective environmental decision-making. Semantic transparency in CS [2,8,10,14,15] and free software [16,17] are discussed as possible mitigations (b) . Software uncertainty, black-boxes and free software. Integrated natural resources modelling and management (INRMM) [29] frequently exploits chains of nontrivial data-transformation models (D- TM), each of them affected by uncertainties and errors. Those D-TM chains may be packaged as monolithic specialized models, maybe only accessible as black-box executables (if accessible at all) [50]. For end-users, black-boxes merely transform inputs in the final outputs, relying on classical peer-reviewed publications for describing the internal mechanism. While software tautologically plays a vital role in CS, it is often neglected in favour of more theoretical aspects. This paradox has been provocatively described as "the invisibility of software in published science. Almost all published papers required some coding, but almost none mention software, let alone include or link to source code" [51]. Recently, this primacy of theory over reality [52-54] has been challenged by new emerging hybrid approaches [55] and by the growing debate on open science and scientific knowledge freedom [2,56-59]. In particular, the role of free software has been underlined within the paradigm of reproducible research [50,58-60]. In the spectrum of reproducibility, the free availability of the source code is emphasized [58] as the first step from non-reproducible research (only based on classic peer-reviewed publications) toward reproducibility. Applying this paradigm to WSTMe, an alternative strategy to black-boxes would suggest exposing not only final outputs but also key intermediate layers of data and information along with the corresponding free software D- TM modules. A concise, semantically-enhanced modularization [14,15] may help not only to see the code (as a very basic prerequisite for semantic transparency) but also to understand - and correct - it [61]. Semantically-enhanced, concise modularization is e.g. supported by semantic array programming (SemAP) [14,15] and its extension to geospatial problems [8,10]. Some WSTMe may surely be classified in the subset of software systems which "are growing well past the ability of a small group of people to completely understand the content", while "data from these systems are often used for critical decision making" [52]. In this context, the further uncertainty arising from the unpredicted "(not to say unpredictable)" [53] behaviour of software errors propagation in WSTMe should be explicitly considered as software uncertainty [62,63]. Thedata and informationflow ofa black- box D-TM isoften a(hidden)compositionofD-TM modules: Semantics and design diversity. Silent faults [64] are a critical class of software errors altering computation output without evident symptoms - such as computation premature interruption (exceptions, error messages, ...), obviously unrealistic results or computation patterns (e.g. noticeably shorter/longer or endless computations). As it has been underlined, "many scientific results are corrupted, perhaps fatally so, by undiscovered mistakes in the software used to calculate and present those results" [65]. Despite the ubiquity of software errors [62-70], the structural role of scientific software uncertainty seems dramatically underestimated [2,53]. Semantic D- TM modularization might help to catch at least a subset of silent faults, when misusing intermediate data outside the expected semantic context of a given D- TM module (b). Where the complexity and scale of WSTMe may lead unavoidable software-uncertainty to induce or worsen deep-uncertainty [2], techniques such as ensemble modelling may be recommendable [11-13]. Adapting those techniques for glancing at the software-uncertainty of a given WSTMe would imply availability of multiple instances (implementations) of the same abstract WSTMe. Independently re-implementing the same WSTMe (design diversity [71]) might of course be extremely expensive. However, partly independent re-implementations of critical D- TM modules may be more affordable and examples of comparison between supposedly equivalent D- TM algorithms seem to corroborate the interest of this research option [59,72,51]. References Casagrandi, R., Guariso, G., 2009. Impact of ICT in environmental sciences: A citation analysis 1990-2007. Environmental Modelling & Software 24 (7), 865-871. http://dx.doi.org/10.1016/j.envsoft.2008.11.013 de Rigo, D., 2013. Behind the horizon of reproducible integrated environmental modelling at European scale: ethics and practice of scientific knowledge freedom. F1000 Research. To appear as discussion paper Gomes, C. P., 2009. Computational sustainability: Computational methods for a sustainable environment, economy, and society. The Bridge 39 (4), 5-13. http://www.nae.edu/File.aspx?id=17673 Easterbrook, S. M., Johns, T. C., 2009. Engineering the software for understanding climate change. Computing in Science & Engineering 11 (6), 65-74. http://dx.doi.org/10.1109/MCSE.2009.193 Hamarat, C., Kwakkel, J. H., Pruyt, E., 2012. Adaptive robust design under deep uncertainty. Technological Forecasting and Social Change. http://dx.doi.org/10.1016/j.techfore.2012.10.004 Bankes, S. C., 2002. Tools and techniques for developing policies for complex and uncertain systems. Proceedings of the National Academy of Sciences of the United States of America 99 (Suppl 3), 7263-7266. http://dx.doi.org/10.1073/pnas.092081399 Kandlikar, M., Risbey, J., Dessai, S., 2005. Representing and communicating deep uncertainty in climate-change assessments. Comptes Rendus Geoscience 337 (4), 443-455. http://dx.doi.org/10.1016/j.crte.2004.10.010 de Rigo, D., Corti, P., Caudullo, G., McInerney, D., Di Leo, M., San-Miguel-Ayanz, J., 2013. Toward Open Science at the European scale: Geospatial Semantic Array Programming for Integrated Environmental Modelling. Geophysical Research Abstracts 15, EGU General Assembly 2013 Rodriguez Aseretto, D., Di Leo, M., de Rigo, D., Corti, P., McInerney, D., Camia, A., San Miguel-Ayanz, J., 2013. Free and Open Source Software underpinning the European Forest Data Centre. Geophysical Research Abstracts 15, EGU General Assembly 2013 de Rigo, D., Corti, P., Caudullo, G., McInerney, D., Di Leo, M., San-Miguel-Ayanz, J., (exp. 2013). Supporting Environmental Modelling and Science-Policy Interface at European Scale with Geospatial Semantic Array Programming. In prep. Lempert, R. J., 2002. A new decision sciences for complex systems. Proceedings of the National Academy of Sciences of the United States of America 99 (Suppl 3), 7309-7313. http://dx.doi.org/10.1073/pnas.082081699 Kandlikar, M., Risbey, J., Dessai, S., 2005. Representing and communicating deep uncertainty in climate-change assessments. Comptes Rendus Geoscience 337 (4), 443-455. http://dx.doi.org/10.1016/j.crte.2004.10.010 Gober, P., Kirkwood, C. W., 2010. Vulnerability assessment of climate-induced water shortage in Phoenix. Proceedings of the National Academy of Sciences 107 (50), 21295-21299. http://dx.doi.org/10.1073/pnas.0911113107 de Rigo, D., 2012. Semantic Array Programming for Environmental Modelling: Application of the Mastrave library. In: Seppelt, R., Voinov, A. A., Lange, S., Bankamp, D. (Eds.), International Environmental Modelling and Software Society (iEMSs) 2012 International Congress on Environmental Modelling and Software. Managing Resources of a Limited Planet: Pathways and Visions under Uncertainty, Sixth Biennial Meeting. pp. 1167-1176. http://www.iemss.org/iemss2012/proceedings/D3_1_0715_deRigo.pdf de Rigo, D., 2012. Semantic Array Programming with Mastrave - Introduction to Semantic Computational Modelling. http://mastrave.org/doc/MTV-1.012-1 Free Software Foundation, 2012. What is free software? http://www.gnu.org/philosophy/free-sw.html (revision 1.118 archived at http://www.webcitation.org/6DXqCFAN3 ) Stallman, R. M., 2009. Viewpoint: Why "open source" misses the point of free software. Communications of the ACM 52 (6), 31-33. http://dx.doi.org/10.1145/1516046.1516058 (free access version: http://www.gnu.org/philosophy/open-source-misses-the-point.html ) Lempert, R., Schlesinger, M. E., Jul. 2001. Climate-change strategy needs to be robust. Nature 412 (6845), 375. http://dx.doi.org/10.1038/35086617 Shell, K. M., Nov. 2012. Constraining cloud feedbacks. Science 338 (6108), 755-756. http://dx.doi.org/10.1126/science.1231083 van der Sluijs, J. P., 2012. Uncertainty and dissent in climate risk assessment: A Post-Normal perspective. Nature and Culture 7 (2), 174-195. http://dx.doi.org/10.3167/nc.2012.070204 Lenton, T. M., Held, H., Kriegler, E., Hall, J. W., Lucht, W., Rahmstorf, S., Schellnhuber, H. J., Feb. 2008. Tipping elements in the earth's climate system. Proceedings of the National Academy of Sciences 105 (6), 1786-1793. http://dx.doi.org/10.1073/pnas.0705414105 Hastings, A., Wysham, D. B., Apr. 2010. Regime shifts in ecological systems can occur with no warning. Ecology Letters 13 (4), 464-472. http://dx.doi.org/10.1111/j.1461-0248.2010.01439.x Barnosky, A. D., Hadly, E. A., Bascompte, J., Berlow, E. L., Brown, J. H., Fortelius, M., Getz, W. M., Harte, J., Hastings, A., Marquet, P. A., Martinez, N. D., Mooers, A., Roopnarine, P., Vermeij, G., Williams, J. W., Gillespie, R., Kitzes, J., Marshall, C., Matzke, N., Mindell, D. P., Revilla, E., Smith, A. B., Jun. 2012. Approaching a state shift in earth/'s biosphere. Nature 486 (7401), 52-58. http://dx.doi.org/10.1038/nature11018 Lenton, T. M., Held, H., Kriegler, E., Hall, J. W., Lucht, W., Rahmstorf, S., Schellnhuber, H. J., Feb. 2008. Tipping elements in the earth's climate system. Proceedings of the National Academy of Sciences 105 (6), 1786-1793. http://dx.doi.org/10.1073/pnas.0705414105 Milly, P. C. D., Betancourt, J., Falkenmark, M., Hirsch, R. M., Kundzewicz, Z. W., Lettenmaier, D. P., Stouffer, R. J., 2008. Stationarity is dead: Whither water management? Science 319 (5863), 573-574. http://dx.doi.org/10.1126/science.1151915 Sloan, S., Pelletier, J., 2012. How accurately may we project tropical forest-cover change? a validation of a forward-looking baseline for REDD. Global Environmental Change 22 (2), 440-453. http://dx.doi.org/10.1016/j.gloenvcha.2012.02.001 Nabuurs, G. J., van Putten, B., Knippers, T. S., Mohren, G. M. J., 2008. Comparison of uncertainties in carbon sequestration estimates for a tropical and a temperate forest. Forest Ecology and Management 256 (3), 237-245. http://dx.doi.org/10.1016/j.foreco.2008.04.010 Green, D. G., Sadedin, S., Jun. 2005. Interactions matter-complexity in landscapes and ecosystems. Ecological Complexity 2 (2), 117-130. http://dx.doi.org/10.1016/j.ecocom.2004.11.006 de Rigo, D. 2012. Integrated Natural Resources Modelling and Management: minimal redefinition of a known challenge for environmental modelling. Excerpt from the Call for a shared research agenda toward scientific knowledge freedom, Maieutike Research Initiative. http://www.citeulike.org/groupfunc/15400/home Baker, R., Koch, F., Kriticos, D., Rafoss, T., Venette, R., van der Werf, W. (Eds.), 2012. Advancing risk assessment models for invasive alien species in the food chain: contending with climate change, economics and uncertainty. Vol. 7 of Bioforsk FOKUS. Bioforsk, Frederik A. Dahls vei 20, 1432 Ås, Norway. http://www.pestrisk.org/2012/BioforskFOKUS7-10_IPRMW-VI.pdf de Rigo, D., Caudullo, G., San-Miguel-Ayanz, J., Stancanelli, G., 2012. Mapping European forest tree species distribution to support pest risk assessment. In: Baker, R., Koch, F., Kriticos, D., Rafoss, T., Venette, R., van der Werf, W. (Eds.), Advancing risk assessment models for invasive alien species in the food chain: contending with climate change, economics and uncertainty. Vol. 7 of Bioforsk FOKUS. Bioforsk, Frederik A. Dahls vei 20, 1432 Ås, Norway. http://www.pestrisk.org/2012/BioforskFOKUS7-10_IPRMW-VI.pdf Thompson, I. D., of the Convention on Biological Diversity, S., 2009. Forest resilience, biodiversity, and climate change : a synthesis of the biodiversity/resilience/stability relationship in forest ecosystems. Secretariat of the Convention on Biological Diversity. ISBN: 9292251376 Center for International Forestry Research., FAO Regional Office for Asia and the Pacific, 2005. Forests and floods: drowning in fiction or thriving on facts? Center for International Forestry Research; Food and Agriculture Organization of the United Nations, Regional Office for Asia and the Pacific. http://www.worldcat.org/isbn/9793361646

43 CFR 17.314 - Age distinctions contained in DOI regulations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

43 CFR 17.314 - Age distinctions contained in DOI regulations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

43 CFR 17.314 - Age distinctions contained in DOI regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

43 CFR 17.314 - Age distinctions contained in DOI regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

43 CFR 17.320 - General responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ASSISTED PROGRAMS OF THE DEPARTMENT OF THE INTERIOR Nondiscrimination on the Basis of Age Duties of Doi Recipients § 17.320 General responsibilities. Each DOI recipient has primary responsibility to ensure that... information, and to afford DOI access to its records to the extent DOI finds necessary to determine whether...

30 CFR 250.1001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... used in this subpart shall have the meanings given below: DOI pipelines include: (1) Producer-operated...) Transporter-operated pipelines that DOI and DOT have agreed are to be regulated as DOI pipelines; and (5) All..., maintenance, and operation; (2) Producer-operated pipelines that DOI and DOT have agreed are to be regulated...

43 CFR 17.314 - Age distinctions contained in DOI regulations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Age distinctions contained in DOI... Age Standards for Determining Age Discrimination § 17.314 Age distinctions contained in DOI regulations. Any age distinctions contained in a rule or regulation issued by DOI shall be presumed to be...

43 CFR 17.331 - Complaints.

Code of Federal Regulations, 2010 CFR

2010-10-01

... or on behalf of others, may file a complaint with DOI, alleging discrimination prohibited by the Act... good cause shown, however, DOI may extend this time limit. (b) DOI will consider the date a complaint... described in paragraphs (a) and (c)(1) of this section. (c) DOI will attempt to facilitate the filing of...

43 CFR 17.320 - General responsibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ASSISTED PROGRAMS OF THE DEPARTMENT OF THE INTERIOR Nondiscrimination on the Basis of Age Duties of Doi Recipients § 17.320 General responsibilities. Each DOI recipient has primary responsibility to ensure that... information, and to afford DOI access to its records to the extent DOI finds necessary to determine whether...

43 CFR 17.331 - Complaints.

Code of Federal Regulations, 2011 CFR

2011-10-01

... or on behalf of others, may file a complaint with DOI, alleging discrimination prohibited by the Act... good cause shown, however, DOI may extend this time limit. (b) DOI will consider the date a complaint... described in paragraphs (a) and (c)(1) of this section. (c) DOI will attempt to facilitate the filing of...

30 CFR 1220.033 - Audits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... which are related to NPSL operations shall be subject to audit by DOI or its appointed agent. Where possible, the auditor for DOI shall coordinate audit efforts with other nonoperators, if any. DOI shall... the same manner as the operator is notified. DOI may elect to send an auditor with the audit team...

The Department of the Interior Strategic Sciences Group and its Response to Hurricane Sandy

NASA Astrophysics Data System (ADS)

Ludwig, K. A.; Machlis, G. E.; Applegate, D.

2013-12-01

This presentation will describe the history, mission, and current activities of the newly formed Department of the Interior (DOI) Strategic Sciences Group (SSG), with a focus on its response to Hurricane Sandy and lessons learned from using scenario building to support decision making. There have been several environmental crises of national significance in recent years, including Hurricane Katrina (2005), large-scale California wildfires (2007-2008), the Deepwater Horizon oil spill (2010), and Hurricane Sandy (2012). Such events are complex because of their impacts on the ecology, economy, and people of the affected locations. In these and other environmental disasters, the DOI has had significant responsibilities to protect people and resources and to engage in emergency response, recovery, and restoration efforts. In recognition of the increasingly critical role of strategic science in responding to such complex events, the DOI established the SSG by Secretarial Order in 2012. Its purpose is to provide the DOI with science-based assessments and interdisciplinary scenarios of environmental crises affecting Departmental resources; rapidly assemble interdisciplinary teams of scientists from government, academia, and non-governmental organizations to conduct such work; and provide results to DOI leadership as usable knowledge to support decision making. March 2013 was the SSG's first deployment since its formation. The SSG's charge was to support DOI's participation on the Hurricane Sandy Rebuilding Task Force by developing scenarios of Hurricane Sandy's environmental, economic, and social consequences in the New York/New Jersey area and potential interventions that could improve regional resilience to future major storms. Over the course of one week, the SSG Sandy team (Operational Group Sandy) identified 13 first-tier consequences and 17 interventions. The SSG briefed DOI leadership, Task Force representatives, and other policy makers in both Washington, DC and the affected region and published an online peer-reviewed report on their results. Subsequently, the DOI used SSG findings to ensure supplemental investments for mitigation projects were prioritized to enhance regional resilience. The SSG is an innovative and flexible tool to support decision making that continues to evolve and show that it has applications across multiple phases of emergency management. The SSG methodology was developed during the Deepwater Horizon oil spill, when its predecessor, the Strategic Sciences Working Group (SSWG), convened to develop scenarios analyzing the cascading consequences of the spill on the Gulf of Mexico. The SSWG was deployed during the height of the emergency, when oil was still flowing from the broken pipe. By comparison, the recent deployment of the SSG was in Sandy's aftermath, when local, state, and federal institutions were focused on rebuilding efforts. Together, these deployments have enabled the SSG to assess its approach to scenario building during both emergency and recovery situations. The SSG continues to identify lessons learned from this experience to use in preparation for future deployments.

A Critical Appraisal of the "Day" Diagram

NASA Astrophysics Data System (ADS)

Roberts, Andrew P.; Tauxe, Lisa; Heslop, David; Zhao, Xiang; Jiang, Zhaoxia

2018-04-01

The "Day" diagram (Day et al., 1977, https://doi.org/10.1016/0031-9201(77)90108-X) is used widely to make inferences about the domain state of magnetic mineral assemblages. Based on theoretical and empirical arguments, the Day diagram is demarcated into stable "single domain" (SD), "pseudo single domain" ("PSD"), and "multidomain" (MD) zones. It is straightforward to make the necessary measurements for a sample and to plot results within the "domain state" framework based on the boundaries defined by Day et al. (1977, https://doi.org/10.1016/0031-9201(77)90108-X). We discuss 10 issues that limit Day diagram interpretation, including (1) magnetic mineralogy, (2) the associated magnetocrystalline anisotropy type, (3) mineral stoichiometry, (4) stress state, (5) surface oxidation, (6) magnetostatic interactions, (7) particle shape, (8) thermal relaxation, (9) magnetic particle mixtures, and (10) definitional/measurement issues. In most studies, these variables are unknowns and cannot be controlled for, so that hysteresis parameters for single bulk samples are nonunique and any data point in a Day diagram could result from infinite combinations of relevant variables. From this critical appraisal, we argue that the Day diagram is fundamentally ambiguous for domain state diagnosis. Widespread use of the Day diagram has also contributed significantly to prevalent but questionable views, including underrecognition of the importance of stable SD particles in the geological record and reinforcement of the unhelpful PSD concept and of its geological importance. Adoption of approaches that enable correct domain state diagnosis should be an urgent priority for component-specific understanding of magnetic mineral assemblages and for quantitative rock magnetic interpretation.

Modeling landslide runout dynamics and hazards: crucial effects of initial conditions

NASA Astrophysics Data System (ADS)

Iverson, R. M.; George, D. L.

2016-12-01

Physically based numerical models can provide useful tools for forecasting landslide runout and associated hazards, but only if the models employ initial conditions and parameter values that faithfully represent the states of geological materials on slopes. Many models assume that a landslide begins from a heap of granular material poised on a slope and held in check by an imaginary dam. A computer instruction instantaneously removes the dam, unleashing a modeled landslide that accelerates under the influence of a large force imbalance. Thus, an unrealistically large initial acceleration influences all subsequent modeled motion. By contrast, most natural landslides are triggered by small perturbations of statically balanced effective stress states, which are commonly caused by rainfall, snowmelt, or earthquakes. Landslide motion begins with an infinitesimal force imbalance and commensurately small acceleration. However, a small initial force imbalance can evolve into a much larger imbalance if feedback causes a reduction in resisting forces. A well-documented source of such feedback involves dilatancy coupled to pore-pressure evolution, which may either increase or decrease effective Coulomb friction—contingent on initial conditions. Landslide dynamics models that account for this feedback include our D-Claw model (Proc. Roy. Soc. Lon., Ser. A, 2014, doi: 10.1098/rspa.2013.0819 and doi:10.1098/rspa.2013.0820) and a similar model presented by Bouchut et al. (J. Fluid Mech., 2016, doi:10.1017/jfm.2016.417). We illustrate the crucial effects of initial conditions and dilatancy coupled to pore-pressure feedback by using D-Claw to perform simple test calculations and also by computing alternative behaviors of the well-documented Oso, Washington, and West Salt Creek, Colorado, landslides of 2014. We conclude that realistic initial conditions and feedbacks are essential elements in numerical models used to forecast landslide runout dynamics and hazards.

A High Resolution Monolithic Crystal, DOI, MR Compatible, PET Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robert S Miyaoka

The principle objective of this proposal is to develop a positron emission tomography (PET) detector with depth-of-interaction (DOI) positioning capability that will achieve state of the art spatial resolution and sensitivity performance for small animal PET imaging. When arranged in a ring or box detector geometry, the proposed detector module will support <1 mm3 image resolution and >15% absolute detection efficiency. The detector will also be compatible with operation in a MR scanner to support simultaneous multi-modality imaging. The detector design will utilize a thick, monolithic crystal scintillator readout by a two-dimensional array of silicon photomultiplier (SiPM) devices using amore » novel sensor on the entrance surface (SES) design. Our hypothesis is that our single-ended readout SES design will provide an effective DOI positioning performance equivalent to more expensive dual-ended readout techniques and at a significantly lower cost. Our monolithic crystal design will also lead to a significantly lower cost system. It is our goal to design a detector with state of the art performance but at a price point that is affordable so the technology can be disseminated to many laboratories. A second hypothesis is that using SiPM arrays, the detector will be able to operate in a MR scanner without any degradation in performance to support simultaneous PET/MR imaging. Having a co-registered MR image will assist in radiotracer localization and may also be used for partial volume corrections to improve radiotracer uptake quantitation. The far reaching goal of this research is to develop technology for medical research that will lead to improvements in human health care.« less

Multipartite quantum correlations and local recoverability

PubMed Central

Wilde, Mark M.

2015-01-01

Characterizing genuine multipartite quantum correlations in quantum physical systems has historically been a challenging problem in quantum information theory. More recently, however, the total correlation or multipartite information measure has been helpful in accomplishing this goal, especially with the multipartite symmetric quantum (MSQ) discord (Piani et al. 2008 Phys. Rev. Lett. 100, 090502. (doi:10.1103/PhysRevLett.100.090502)) and the conditional entanglement of multipartite information (CEMI) (Yang et al. 2008 Phys. Rev. Lett. 101, 140501. (doi:10.1103/PhysRevLett.101.140501)). Here, we apply a recent and significant improvement of strong subadditivity of quantum entropy (Fawzi & Renner 2014 (http://arxiv.org/abs/1410.0664)) in order to develop these quantities further. In particular, we prove that the MSQ discord is nearly equal to zero if and only if the multipartite state for which it is evaluated is approximately locally recoverable after performing measurements on each of its systems. Furthermore, we prove that the CEMI is a faithful entanglement measure, i.e. it vanishes if and only if the multipartite state for which it is evaluated is a fully separable state. Along the way, we provide an operational interpretation of the MSQ discord in terms of the partial state distribution protocol, which in turn, as a special case, gives an interpretation for the original discord quantity. Finally, we prove an inequality that could potentially improve upon the Fawzi–Renner inequality in the multipartite context, but it remains an open question to determine whether this is so. PMID:27547097

The COCCON Paris Experiment - Model-Data Comparison of XCO2 (and XCH4) in an Urban Environment

NASA Astrophysics Data System (ADS)

Vogel, F. R.; Staufer, J.; Frey, M.; Broquet, G.; Xueref-Remy, I.; Sha, M. K.; Blumenstock, T.; Te, Y. V.; Janssen, C.; Jeseck, P.; Chelin, P.; Fratacci, T.; Tu, Q.; Gross, J.; Schäfer, K.; Orphal, J.; Ciais, P.; Hase, F.

2016-12-01

Currently, over 50% of the global population lives in urban areas1 and the future population growth is also predicted to occur mostly in urban centers. While emissions of Greenhouse Gases and carbon-based air pollutants can be estimated quite precisely on national scale using fuel consumption statistics, typically to about 3%-40%2, higher uncertainties of 20%-50% are reported3 for urban GHG emissions. Atmospheric observations, when combined with inversion modelling can allow independently assessing such urban emission inventories4. This study investigates how well novel low-resolution FTS observations can be represented within atmospheric transport models used in such inversion systems, which would be the pre-requisite for a future system based on XCO2 observations. A network of five EM27sun instruments5,6was deployed across the Paris Metropolitan region (upwind, downwind and inside of Paris, diameter ca. 40km) for a three week period in spring 2015. Observed XCO2 significantly varies during this period ranging from 400.5ppm to 406ppm. A decrease in XCO2 throughout the day, likely driven by the biogenic CO2 uptake in the region, is recorded at all sites. Both observational and simulated XCO2 also clearly show that the emissions in the Paris region significantly increase XCO2 (0-2ppm), depending on meteorological conditions. The observational data is compared to three configurations of our XCO2 forward model to assess their performance. We find that all simulations and observations agree qualitatively and that the gradient of XCO2 over Paris can also be reproduced quantitatively for specific meteorological conditions and optimal model setup. 1United Nations, Department of Economic and Social Affairs, Population Division (2014). World Urbanization Prospects: The 2014 Revision 2Anders et al. 2014, Tellus B 2014, 66, 23616, http://dx.doi.org/10.3402/tellusb.v66.23616 3Wu et al. 2016, Atmos. Chem. Phys., 16, 7743-7771, doi:10.5194/acp-16-7743-2016 4Staufer et al. 2016, Atmos. Chem. Phys. Diss., under review for ACP, doi:10.5194/acp-2016-191 5Gisi et al., Atmos. Meas. Tech., 5, 2969-2980, doi:10.5194/amt-5-2969-2012, 2012 6Hase et al. 2015, Atmos. Meas. Tech., 8, 3047-3057, doi :10.5194/amt-8-3047-2015

Strategies for estimating the water budget at different scales using the JGrass-NewAGE system

NASA Astrophysics Data System (ADS)

Bancheri, M.; Rigon, R.; Serafin, F.; Abera, W.; Bottazzi, M.

2017-12-01

Recently we presented two papers one dedicated to the estimation of the water budget components in a small, basin, the Posina catchment [Abera et al., 2017], and the other in a large basin, the Blue Nile [Abera et al., 2017b]. At the smallest scale the ground measurements available do not guarantee the closure of the budget without making additional hypothesis. The large scale case, instead, was largely supported by remote sensing data either for calibration and/or validation. This contribution explains how we actually did it, clarifies some aspects of the informatics and openly discusses the issues risen in our work. We also consider varying configuration of the water budget schemes at the subbasin level, and how this affects the estimates.Finally we analyse the problem of travel times [Rigon et al., 2016a, Rigon et al, 2016b] as it comes out from considering the multiple fluxes and storages. All considerations and simulations are based on the JGrass-NewAGE system [Formetta et al., 2014] and its evolution (Bancheri [2017]).ReferencesAbera, W., Formetta, G., Borga, M., & Rigon, R. (2017a). Estimating the water budget components and their variability in a pre-alpine basin with JGrass-NewAGE. Advances in Water Resources, http://doi.org/10.1016/j.advwatres.2017.03.010Abera, W., Formetta, G., Brocca, L., & Rigon, R. (2017b). Modeling the water budget of the Upper Blue Nile basin using the JGrass-NewAge model system and satellite data. Hydrology and Earth System Sciences. http://doi.org/10.5194/hess-21-3145-2017Bancheri, M., A travel time model for water budget of complex catchments, ph.D Thesis, 2017Formetta, G., Antonello, A., Franceschi, S., David, O., & Rigon, R. (2014). Hydrological modelling with components: A GIS-based open-source framework. Environmental Modelling and Software,. http://doi.org/10.1016/j.envsoft.2014.01.019Rigon, R., Bancheri, M., Formetta, G., & de Lavenne, A. (2016). The geomorphological unit hydrograph from a historical-critical perspective. Earth Surface Processes and Landform. http://doi.org/10.1002/esp.3855Rigon, R., Bancheri, M., & Green, T. R. (2016). Age-ranked hydrological budgets and a travel time description of catchment hydrology. Hydrology and Earth System Sciences. http://doi.org/10.5194/hess-20-4929-2016

Observing and Modeling Snow Processes Across Spatial and Temporal Scales in Rocky Mountain Headwater Catchments

NASA Astrophysics Data System (ADS)

Bearup, L. A.; Carroll, R. W. H.; Williams, K. H.; Maxwell, R. M.; Foster, L.

2016-12-01

Recently we presented two papers one dedicated to the estimation of the water budget components in a small, basin, the Posina catchment [Abera et al., 2017], and the other in a large basin, the Blue Nile [Abera et al., 2017b]. At the smallest scale the ground measurements available do not guarantee the closure of the budget without making additional hypothesis. The large scale case, instead, was largely supported by remote sensing data either for calibration and/or validation. This contribution explains how we actually did it, clarifies some aspects of the informatics and openly discusses the issues risen in our work. We also consider varying configuration of the water budget schemes at the subbasin level, and how this affects the estimates.Finally we analyse the problem of travel times [Rigon et al., 2016a, Rigon et al, 2016b] as it comes out from considering the multiple fluxes and storages. All considerations and simulations are based on the JGrass-NewAGE system [Formetta et al., 2014] and its evolution (Bancheri [2017]).ReferencesAbera, W., Formetta, G., Borga, M., & Rigon, R. (2017a). Estimating the water budget components and their variability in a pre-alpine basin with JGrass-NewAGE. Advances in Water Resources, http://doi.org/10.1016/j.advwatres.2017.03.010Abera, W., Formetta, G., Brocca, L., & Rigon, R. (2017b). Modeling the water budget of the Upper Blue Nile basin using the JGrass-NewAge model system and satellite data. Hydrology and Earth System Sciences. http://doi.org/10.5194/hess-21-3145-2017Bancheri, M., A travel time model for water budget of complex catchments, ph.D Thesis, 2017Formetta, G., Antonello, A., Franceschi, S., David, O., & Rigon, R. (2014). Hydrological modelling with components: A GIS-based open-source framework. Environmental Modelling and Software,. http://doi.org/10.1016/j.envsoft.2014.01.019Rigon, R., Bancheri, M., Formetta, G., & de Lavenne, A. (2016). The geomorphological unit hydrograph from a historical-critical perspective. Earth Surface Processes and Landform. http://doi.org/10.1002/esp.3855Rigon, R., Bancheri, M., & Green, T. R. (2016). Age-ranked hydrological budgets and a travel time description of catchment hydrology. Hydrology and Earth System Sciences. http://doi.org/10.5194/hess-20-4929-2016

Single unit action potentials in humans and the effect of seizure activity

PubMed Central

Merricks, Edward M.; Smith, Elliot H.; McKhann, Guy M.; Goodman, Robert R.; Bateman, Lisa M.; Emerson, Ronald G.

2015-01-01

Spike-sorting algorithms have been used to identify the firing patterns of isolated neurons (‘single units’) from implanted electrode recordings in patients undergoing assessment for epilepsy surgery, but we do not know their potential for providing helpful clinical information. It is important therefore to characterize both the stability of these recordings and also their context. A critical consideration is where the units are located with respect to the focus of the pathology. Recent analyses of neuronal spiking activity, recorded over extended spatial areas using microelectrode arrays, have demonstrated the importance of considering seizure activity in terms of two distinct spatial territories: the ictal core and penumbral territories. The pathological information in these two areas, however, is likely to be very different. We investigated, therefore, whether units could be followed reliably over prolonged periods of times in these two areas, including during seizure epochs. We isolated unit recordings from several hundred neurons from four patients undergoing video-telemetry monitoring for surgical evaluation of focal neocortical epilepsies. Unit stability could last in excess of 40 h, and across multiple seizures. A key finding was that in the penumbra, spike stereotypy was maintained even during the seizure. There was a net tendency towards increased penumbral firing during the seizure, although only a minority of units (10–20%) showed significant changes over the baseline period, and notably, these also included neurons showing significant reductions in firing. In contrast, within the ictal core territories, regions characterized by intense hypersynchronous multi-unit firing, our spike sorting algorithms failed as the units were incorporated into the seizure activity. No spike sorting was possible from that moment until the end of the seizure, but recovery of the spike shape was rapid following seizure termination: some units reappeared within tens of seconds of the end of the seizure, and over 80% reappeared within 3 min (τrecov = 104 ± 22 s). The recovery of the mean firing rate was close to pre-ictal levels also within this time frame, suggesting that the more protracted post-ictal state cannot be explained by persistent cellular neurophysiological dysfunction in either the penumbral or the core territories. These studies lay the foundation for future investigations of how these recordings may inform clinical practice. See Kimchi and Cash (doi:10.1093/awv264) for a scientific commentary on this article. PMID:26187332

76 FR 77831 - 2012 Presidential Candidate Matching Fund Submission Dates and Post Date of Ineligibility Dates...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... statement'') after their dates of ineligibility (``DOI''). Candidates are required to submit a NOCO... notified of their DOI by the Commission. A Candidate who has net outstanding campaign obligations post-DOI... each matching fund request submitted after the candidate's DOI. These statements are due just before...

Prototype pre-clinical PET scanner with depth-of-interaction measurements using single-layer crystal array and single-ended readout

NASA Astrophysics Data System (ADS)

Lee, Min Sun; Kim, Kyeong Yun; Ko, Guen Bae; Lee, Jae Sung

2017-05-01

In this study, we developed a proof-of-concept prototype PET system using a pair of depth-of-interaction (DOI) PET detectors based on the proposed DOI-encoding method and digital silicon photomultiplier (dSiPM). Our novel cost-effective DOI measurement method is based on a triangular-shaped reflector that requires only a single-layer pixelated crystal and single-ended signal readout. The DOI detector consisted of an 18  ×  18 array of unpolished LYSO crystal (1.47  ×  1.47  ×  15 mm3) wrapped with triangular-shaped reflectors. The DOI information was encoded by depth-dependent light distribution tailored by the reflector geometry and DOI correction was performed using four-step depth calibration data and maximum-likelihood (ML) estimation. The detector pair and the object were placed on two motorized rotation stages to demonstrate 12-block ring PET geometry with 11.15 cm diameter. Spatial resolution was measured and phantom and animal imaging studies were performed to investigate imaging performance. All images were reconstructed with and without the DOI correction to examine the impact of our DOI measurement. The pair of dSiPM-based DOI PET detectors showed good physical performances respectively: 2.82 and 3.09 peak-to-valley ratios, 14.30% and 18.95% energy resolution, and 4.28 and 4.24 mm DOI resolution averaged over all crystals and all depths. A sub-millimeter spatial resolution was achieved at the center of the field of view (FOV). After applying ML-based DOI correction, maximum 36.92% improvement was achieved in the radial spatial resolution and a uniform resolution was observed within 5 cm of transverse PET FOV. We successfully acquired phantom and animal images with improved spatial resolution and contrast by using the DOI measurement. The proposed DOI-encoding method was successfully demonstrated in the system level and exhibited good performance, showing its feasibility for animal PET applications with high spatial resolution and sensitivity.

Wikipedia as a gateway to biomedical research: The relative distribution and use of citations in the English Wikipedia

PubMed Central

Willinsky, John M.; Steinberg, Ryan M.; Mietchen, Daniel; Wass, Joseph L.; Dong, Ting

2017-01-01

Wikipedia is a gateway to knowledge. However, the extent to which this gateway ends at Wikipedia or continues via supporting citations is unknown. Wikipedia’s gateway functionality has implications for information design and education, notably in medicine. This study aims to establish benchmarks for the relative distribution and referral (click) rate of citations—as indicated by presence of a Digital Object Identifier (DOI)—from Wikipedia, with a focus on medical citations. DOIs referred from the English Wikipedia in August 2016 were obtained from Crossref.org. Next, based on a DOI’s presence on a WikiProject Medicine page, all DOIs in Wikipedia were categorized as medical (WP:MED) or non-medical (non-WP:MED). Using this categorization, referred DOIs were classified as WP:MED, non-WP:MED, or BOTH, meaning the DOI may have been referred from either category. Data were analyzed using descriptive and inferential statistics. Out of 5.2 million Wikipedia pages, 4.42% (n = 229,857) included at least one DOI. 68,870 were identified as WP:MED, with 22.14% (n = 15,250) featuring one or more DOIs. WP:MED pages featured on average 8.88 DOI citations per page, whereas non-WP:MED pages had on average 4.28 DOI citations. For DOIs only on WP:MED pages, a DOI was referred every 2,283 pageviews and for non-WP:MED pages every 2,467 pageviews. DOIs from BOTH pages accounted for 12% (n = 58,475). The referral of DOI citations found in BOTH could not be assigned to WP:MED or non-WP:MED, as the page from which the referral was made was not provided with the data. While these results cannot provide evidence of greater citation referral from WP:MED than non-WP:MED, they do provide benchmarks to assess strategies for changing referral patterns. These changes might include editors adopting new methods for designing and presenting citations or the introduction of teaching strategies that address the value of consulting citations as a tool for extending learning. PMID:29267345

Next generation PET data acquisition architectures

NASA Astrophysics Data System (ADS)

Jones, W. F.; Reed, J. H.; Everman, J. L.; Young, J. W.; Seese, R. D.

1997-06-01

New architectures for higher performance data acquisition in PET are proposed. Improvements are demanded primarily by three areas of advancing PET state of the art. First, larger detector arrays such as the Hammersmith ECAT/sup (R/) EXACT HR/sup ++/ exceed the addressing capacity of 32 bit coincidence event words. Second, better scintillators (LSO) make depth-of interaction (DOI) and time-of-flight (TOF) operation more practical. Third, fully optimized single photon attenuation correction requires higher rates of data collection. New technologies which enable the proposed third generation Real Time Sorter (RTS III) include: (1) 80 Mbyte/sec Fibre Channel RAID disk systems, (2) PowerPC on both VMEbus and PCI Local bus, and (3) quadruple interleaved DRAM controller designs. Data acquisition flexibility is enhanced through a wider 64 bit coincidence event word. PET methodology support includes DOI (6 bits), TOF (6 bits), multiple energy windows (6 bits), 512/spl times/512 sinogram indexes (18 bits), and 256 crystal rings (16 bits). Throughput of 10 M events/sec is expected for list-mode data collection as well as both on-line and replay histogramming. Fully efficient list-mode storage for each PET application is provided by real-time bit packing of only the active event word bits. Real-time circuits provide DOI rebinning.

43 CFR 17.339 - Exhaustion of administrative remedies.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DOI has made no finding with regard to the complaint; or (2) DOI issues any finding in favor of the recipient. (b) If DOI fails to make a finding within 180 days or issues a finding in favor of the recipient, DOI will: (1) Promptly advise the complainant of this fact; (2) Advise the complainant of his or her...

41 CFR 102-75.635 - What information must the Department of the Interior (DOI) furnish eligible public agencies?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What information must the Department of the Interior (DOI) furnish eligible public agencies? 102-75.635 Section 102-75.635... the Interior (DOI) furnish eligible public agencies? Upon request, DOI must furnish eligible public...

75 FR 55315 - Seminole Energy Services, LLC; Seminole Gas Company, LLC; Seminole High Plains, LLC; Lakeshore...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... Investigations (DOI) as non- decisional staff in deliberations by the Commission in this docket. By this order... of Enforcement, Larry Parkinson, Director, DOI, and Geof Hobday of DOI to the January 15, 2009 list of staff excepted from the DOI non-decisional staff designation. Kimberly D. Bose, Secretary. [FR Doc...

41 CFR 102-75.635 - What information must the Department of the Interior (DOI) furnish eligible public agencies?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What information must the Department of the Interior (DOI) furnish eligible public agencies? 102-75.635 Section 102-75.635... the Interior (DOI) furnish eligible public agencies? Upon request, DOI must furnish eligible public...

30 CFR 250.1006 - How must I decommission and take out of service a DOI pipeline?

Code of Federal Regulations, 2011 CFR

2011-07-01

... a DOI pipeline? 250.1006 Section 250.1006 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT... out of service a DOI pipeline? (a) The requirements for decommissioning pipelines are listed in § 250.1750 through § 250.1754. (b) The table in this section lists the requirements if you take a DOI...

41 CFR 102-75.665 - What happens after the disposal agency receives the assignment recommendation from DOI?

Code of Federal Regulations, 2011 CFR

2011-01-01

... disposal agency receives the assignment recommendation from DOI? 102-75.665 Section 102-75.665 Public... assignment recommendation from DOI? If, after considering other uses for the property, the disposal agency approves the assignment recommendation from DOI, it must assign the property by letter or other document to...

Reduction chemistry of neptunium cyclopentadienide complexes: from structure to understanding† †Electronic supplementary information (ESI) available: General procedures, synthetic details, spectroscopic data, X-ray crystallographic data. CCDC 1524162–1524166. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00034k Click here for additional data file. Click here for additional data file.

PubMed Central

Dutkiewicz, Michał S.; Apostolidis, Christos

2017-01-01

Neptunium complexes in the formal oxidation states II, III, and IV supported by cyclopentadienyl ligands are explored, and significant differences between Np and U highlighted as a result. A series of neptunium(iii) cyclopentadienyl (Cp) complexes [Np(Cp)3], its bis-acetonitrile adduct [Np(Cp)3(NCMe)2], and its KCp adduct K[Np(Cp)4] and [Np(Cp′)3] (Cp′ = C5H4SiMe3) have been made and characterised providing the first single crystal X-ray analyses of NpIII Cp complexes. In all NpCp3 derivatives there are three Cp rings in η5-coordination around the NpIII centre; additionally in [Np(Cp)3] and K[Np(Cp)4] one Cp ring establishes a μ-η1-interaction to one C atom of a neighbouring Np(Cp)3 unit. The solid state structure of K[Np(Cp)4] is unique in containing two different types of metal–Cp coordination geometries in the same crystal. NpIII(Cp)4 units are found exhibiting four units of η5-coordinated Cp rings like in the known complex [NpIV(Cp)4], the structure of which is now reported. A detailed comparison of the structures gives evidence for the change of ionic radii of ca. –8 pm associated with change in oxidation state between NpIII and NpIV. The rich redox chemistry associated with the syntheses is augmented by the reduction of [Np(Cp′)3] by KC8 in the presence of 2.2.2-cryptand to afford a neptunium(ii) complex that is thermally unstable above –10 °C like the UII and ThII complexes K(2.2.2-cryptand)[Th/U(Cp′)3]. Together, these spontaneous and controlled redox reactions of organo-neptunium complexes, along with information from structural characterisation, show the relevance of organometallic Np chemistry to understanding fundamental structure and bonding in the minor actinides. PMID:28553487

Condensins under the microscope.

PubMed

Maeshima, Kazuhiro; Hibino, Kayo; Hudson, Damien F

2018-04-30

Condensins are key players in mitotic chromosome condensation. Using an elegant combination of state-of-the-art imaging techniques, Walther et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801048) counted the number of Condensins, examined their behaviors on human mitotic chromosomes, and integrated the quantitative data to propose a new mechanistic model for chromosome condensation. © 2018 Maeshima et al.

Erratum to: Less depressed or less forthcoming? Self-report of depression symptoms in women preparing for in vitro fertilization.

PubMed

Lewis, Adam M; Liu, Dawei; Stuart, Scott P; Ryan, Ginny

2015-04-01

Erratum to: Arch Womens Ment Health (2013) 16:87–92 DOI 10.1007/s00737-012-0317-8. The original version of this article unfortunately missed the Acknowledgment which is stated below: “This work was partially supported by a grant from the NICHD (K12-HD063117).”

Optimization Via Open System Quantum Annealing

DTIC Science & Technology

2016-01-07

Daniel A. Lidar. Experimental signature of programmable quantum annealing, Nature Communications , (06 2013): 0. doi: 10.1038/ncomms3067 T. F...Demonstrated error correction effectiveness. • Demonstrated quantum annealing correction on antiferromagnetic chains, with substantial fidelity gains...Rev. A 91, 022309 (2015). 3. A. Kalev and I. Hen, “ Fidelity -optimized quantum state estimation”, New Journal of Physics 17 092008 (2015). 4. I

A Three-Legged Stool or Race? Governance Models for NOAA RISAs, DOI CSCs, and USDA Climate Hubs

NASA Astrophysics Data System (ADS)

Foster, J. G.

2014-12-01

NOAAs Regional Integrated Sciences and Assessments (RISA) Teams, DOIs Climate Science Centers (CSCs), and USDAs Regional Climate Hubs (RCHs) have common missions of integrating climate and related knowledge across scientific disciplines and regions to create "actionable" information that decision-makes can use to manage climate risks and impacts at state and local scales. However, the sponsoring agency programs, university investigators, and local federal officials govern each differently. The three models of program and center governance are 1) exclusively university (RISAs), 2) a hybrid of Federal government and (host) university (CSCs,), and 3) exclusively Federal (Hubs). Each model has it's advantages and disadvantages in terms of legal definition and authority, scientific mission requirements and strategies, flexibility and legitimacy to conduct research and to collaborate regionally with constituencies, leadership and governance approach and "friction points,", staff capacity and ability to engage stakeholders, necessity to deliver products and services, bureaucratic oversight, performance evaluation, and political support at Congressional, state, and local levels. Using available sources of information and data, this paper will compare and contrast the strengths and weakness of these three regional applied climate science center governance models.

Consistent global structures of complex RNA states through multidimensional chemical mapping

PubMed Central

Cheng, Clarence Yu; Chou, Fang-Chieh; Kladwang, Wipapat; Tian, Siqi; Cordero, Pablo; Das, Rhiju

2015-01-01

Accelerating discoveries of non-coding RNA (ncRNA) in myriad biological processes pose major challenges to structural and functional analysis. Despite progress in secondary structure modeling, high-throughput methods have generally failed to determine ncRNA tertiary structures, even at the 1-nm resolution that enables visualization of how helices and functional motifs are positioned in three dimensions. We report that integrating a new method called MOHCA-seq (Multiplexed •OH Cleavage Analysis with paired-end sequencing) with mutate-and-map secondary structure inference guides Rosetta 3D modeling to consistent 1-nm accuracy for intricately folded ncRNAs with lengths up to 188 nucleotides, including a blind RNA-puzzle challenge, the lariat-capping ribozyme. This multidimensional chemical mapping (MCM) pipeline resolves unexpected tertiary proximities for cyclic-di-GMP, glycine, and adenosylcobalamin riboswitch aptamers without their ligands and a loose structure for the recently discovered human HoxA9D internal ribosome entry site regulon. MCM offers a sequencing-based route to uncovering ncRNA 3D structure, applicable to functionally important but potentially heterogeneous states. DOI: http://dx.doi.org/10.7554/eLife.07600.001 PMID:26035425

Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence

PubMed Central

Heintz, Udo; Schlichting, Ilme

2016-01-01

The design of synthetic optogenetic tools that allow precise spatiotemporal control of biological processes previously inaccessible to optogenetic control has developed rapidly over the last years. Rational design of such tools requires detailed knowledge of allosteric light signaling in natural photoreceptors. To understand allosteric communication between sensor and effector domains, characterization of all relevant signaling states is required. Here, we describe the mechanism of light-dependent DNA binding of the light-oxygen-voltage (LOV) transcription factor Aureochrome 1a from Phaeodactylum tricornutum (PtAu1a) and present crystal structures of a dark state LOV monomer and a fully light-adapted LOV dimer. In combination with hydrogen/deuterium-exchange, solution scattering data and DNA-binding experiments, our studies reveal a light-sensitive interaction between the LOV and basic region leucine zipper DNA-binding domain that together with LOV dimerization results in modulation of the DNA affinity of PtAu1a. We discuss the implications of these results for the design of synthetic LOV-based photosensors with application in optogenetics. DOI: http://dx.doi.org/10.7554/eLife.11860.001 PMID:26754770

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

PubMed Central

Pal, Debjani; Pertot, Anja; Shirole, Nitin H; Yao, Zhan; Anaparthy, Naishitha; Garvin, Tyler; Cox, Hilary; Chang, Kenneth; Rollins, Fred; Kendall, Jude; Edwards, Leyla; Singh, Vijay A; Stone, Gary C; Schatz, Michael C; Hicks, James; Hannon, Gregory J; Sordella, Raffaella

2017-01-01

Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanisms are cells characterized by a CD44+/CD24− cell surface marker profile. Here, we report that human CD44+/CD24− cancer cells are genetically highly unstable because of intrinsic defects in their DNA-repair capabilities. In fact, in CD44+/CD24− cells, constitutive activation of the TGF-beta axis was both necessary and sufficient to reduce the expression of genes that are crucial in coordinating DNA damage repair mechanisms. Consequently, we observed that cancer cells that reside in a CD44+/CD24− state are characterized by increased accumulation of DNA copy number alterations, greater genetic diversity and improved adaptability to drug treatment. Together, these data suggest that the transition into a CD44+/CD24− cell state can promote intra-tumor genetic heterogeneity, spur tumor evolution and increase tumor fitness. DOI: http://dx.doi.org/10.7554/eLife.21615.001 PMID:28092266

A Three-Legged Stool or Race? Governance Models for NOAA RISAs, DOI CSCs, and USDA Climate Hub

NASA Astrophysics Data System (ADS)

Foster, J. G.

2014-12-01

NOAAs Regional Integrated Sciences and Assessments (RISA) Teams, DOIs Climate Science Centers (CSCs), and USDAs Regional Climate Hubs (RCHs) have common missions of integrating climate and related knowledge across scientific disciplines and regions to create "actionable" information that decision-makes can use to manage climate risks and impacts at state and local scales. However, the sponsoring agency programs, university investigators, and local federal officials govern each differently. The three models of program and center governance are 1) exclusively university (RISAs), 2) a hybrid of Federal government and (host) university (CSCs,), and 3) exclusively Federal (Hubs). Each model has it's advantages and disadvantages in terms of legal definition and authority, scientific mission requirements and strategies, flexibility and legitimacy to conduct research and to collaborate regionally with constituencies, leadership and governance approach and "friction points,", staff capacity and ability to engage stakeholders, necessity to deliver products and services, bureaucratic oversight, performance evaluation, and political support at Congressional, state, and local levels. Using available sources of information and data, this paper will compare and contrast the strengths and weakness of these three regional applied climate science center governance models.

Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

PubMed Central

Fidler, Aaron L; Darris, Carl E; Chetyrkin, Sergei V; Pedchenko, Vadim K; Boudko, Sergei P; Brown, Kyle L; Gray Jerome, W; Hudson, Julie K; Rokas, Antonis; Hudson, Billy G

2017-01-01

The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, spongin short-chain collagens, of non-bilaterian animal phyla. We identified basement membrane (BM) and collagen IV in Ctenophora, and show that the structural and genomic features of collagen IV are homologous to those of non-bilaterian animal phyla and Bilateria. Yet, ctenophore features are more diverse and distinct, expressing up to twenty genes compared to six in vertebrates. Moreover, collagen IV is absent in unicellular sister-groups. Collectively, we conclude that collagen IV and its variant, spongin, are primordial components of the extracellular microenvironment, and as a component of BM, collagen IV enabled the assembly of a fundamental architectural unit for multicellular tissue genesis. DOI: http://dx.doi.org/10.7554/eLife.24176.001 PMID:28418331

Geological and taphonomic context for the new hominin species Homo naledi from the Dinaledi Chamber, South Africa

PubMed Central

Dirks, Paul HGM; Berger, Lee R; Roberts, Eric M; Kramers, Jan D; Hawks, John; Randolph-Quinney, Patrick S; Elliott, Marina; Musiba, Charles M; Churchill, Steven E; de Ruiter, Darryl J; Schmid, Peter; Backwell, Lucinda R; Belyanin, Georgy A; Boshoff, Pedro; Hunter, K Lindsay; Feuerriegel, Elen M; Gurtov, Alia; Harrison, James du G; Hunter, Rick; Kruger, Ashley; Morris, Hannah; Makhubela, Tebogo V; Peixotto, Becca; Tucker, Steven

2015-01-01

We describe the physical context of the Dinaledi Chamber within the Rising Star cave, South Africa, which contains the fossils of Homo naledi. Approximately 1550 specimens of hominin remains have been recovered from at least 15 individuals, representing a small portion of the total fossil content. Macro-vertebrate fossils are exclusively H. naledi, and occur within clay-rich sediments derived from in situ weathering, and exogenous clay and silt, which entered the chamber through fractures that prevented passage of coarser-grained material. The chamber was always in the dark zone, and not accessible to non-hominins. Bone taphonomy indicates that hominin individuals reached the chamber complete, with disarticulation occurring during/after deposition. Hominins accumulated over time as older laminated mudstone units and sediment along the cave floor were eroded. Preliminary evidence is consistent with deliberate body disposal in a single location, by a hominin species other than Homo sapiens, at an as-yet unknown date. DOI: http://dx.doi.org/10.7554/eLife.09561.001 PMID:26354289

Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples

PubMed Central

Yu, Feiqiao Brian; Blainey, Paul C; Schulz, Frederik; Woyke, Tanja; Horowitz, Mark A; Quake, Stephen R

2017-01-01

Metagenomics and single-cell genomics have enabled genome discovery from unknown branches of life. However, extracting novel genomes from complex mixtures of metagenomic data can still be challenging and represents an ill-posed problem which is generally approached with ad hoc methods. Here we present a microfluidic-based mini-metagenomic method which offers a statistically rigorous approach to extract novel microbial genomes while preserving single-cell resolution. We used this approach to analyze two hot spring samples from Yellowstone National Park and extracted 29 new genomes, including three deeply branching lineages. The single-cell resolution enabled accurate quantification of genome function and abundance, down to 1% in relative abundance. Our analyses of genome level SNP distributions also revealed low to moderate environmental selection. The scale, resolution, and statistical power of microfluidic-based mini-metagenomics make it a powerful tool to dissect the genomic structure of microbial communities while effectively preserving the fundamental unit of biology, the single cell. DOI: http://dx.doi.org/10.7554/eLife.26580.001 PMID:28678007

Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

PubMed Central

Behrouzi, Reza; Lu, Chenning; Currie, Mark A; Jih, Gloria; Iglesias, Nahid; Moazed, Danesh

2016-01-01

Heterochromatin is a conserved feature of eukaryotic chromosomes with central roles in regulation of gene expression and maintenance of genome stability. Heterochromatin formation involves spreading of chromatin-modifying factors away from initiation points over large DNA domains by poorly understood mechanisms. In Saccharomyces cerevisiae, heterochromatin formation requires the SIR complex, which contains subunits with histone-modifying, histone-binding, and self-association activities. Here, we analyze binding of the Sir proteins to reconstituted mono-, di-, tri-, and tetra-nucleosomal chromatin templates and show that key Sir-Sir interactions bridge only sites on different nucleosomes but not sites on the same nucleosome, and are therefore 'interrupted' with respect to sites on the same nucleosome. We observe maximal binding affinity and cooperativity to unmodified di-nucleosomes and propose that nucleosome pairs bearing unmodified histone H4-lysine16 and H3-lysine79 form the fundamental units of Sir chromatin binding and that cooperative binding requiring two appropriately modified nucleosomes mediates selective Sir recruitment and spreading. DOI: http://dx.doi.org/10.7554/eLife.17556.001 PMID:27835568

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae

PubMed Central

Leyrat, Cedric; Renner, Max; Harlos, Karl; Huiskonen, Juha T; Grimes, Jonathan M

2014-01-01

The M2-1 protein of human metapneumovirus (HMPV) is a zinc-binding transcription antiterminator which is highly conserved among pneumoviruses. We report the structure of tetrameric HMPV M2-1. Each protomer features a N-terminal zinc finger domain and an α-helical tetramerization motif forming a rigid unit, followed by a flexible linker and an α-helical core domain. The tetramer is asymmetric, three of the protomers exhibiting a closed conformation, and one an open conformation. Molecular dynamics simulations and SAXS demonstrate a dynamic equilibrium between open and closed conformations in solution. Structures of adenosine monophosphate- and DNA- bound M2-1 establish the role of the zinc finger domain in base-specific recognition of RNA. Binding to ‘gene end’ RNA sequences stabilized the closed conformation of M2-1 leading to a drastic shift in the conformational landscape of M2-1. We propose a model for recognition of gene end signals and discuss the implications of these findings for transcriptional regulation in pneumoviruses. DOI: http://dx.doi.org/10.7554/eLife.02674.001 PMID:24842877

KSC-07pd2843

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew learn more about the mission payload, the Kibo Experiment Logistics Module Pressurized Section. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2840

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with some of the equipment related to the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2842

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with some of the equipment related to the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2844

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with some of the equipment related to the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2845

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with some of the equipment related to the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2841

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with some of the equipment related to the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

Basic Performance Test of a Prototype PET Scanner Using CdTe Semiconductor Detectors

NASA Astrophysics Data System (ADS)

Ueno, Y.; Morimoto, Y.; Tsuchiya, K.; Yanagita, N.; Kojima, S.; Ishitsu, T.; Kitaguchi, H.; Kubo, N.; Zhao, S.; Tamaki, N.; Amemiya, K.

2009-02-01

A prototype positron emission tomography (PET) scanner using CdTe semiconductor detectors was developed, and its initial evaluation was conducted. The scanner was configured to form a single detector ring with six separated detector units, each having 96 detectors arranged in three detector layers. The field of view (FOV) size was 82 mm in diameter. Basic physical performance indicators of the scanner were measured through phantom studies and confirmed by rat imaging. The system-averaged energy resolution and timing resolution were 5.4% and 6.0 ns (each in FWHM) respectively. Spatial resolution measured at FOV center was 2.6 mm FWHM. Scatter fraction was measured and calculated in a National Electrical Manufacturers Association (NEMA)-fashioned manner using a 3-mm diameter hot capillary in a water-filled 80-mm diameter acrylic cylinder. The calculated result was 3.6%. Effect of depth of interaction (DOI) measurement was demonstrated by comparing hot-rod phantom images reconstructed with and without DOI information. Finally, images of a rat myocardium and an implanted tumor were visually assessed, and the imaging performance was confirmed.

The right hippocampus leads the bilateral integration of gamma-parsed lateralized information

PubMed Central

Benito, Nuria; Martín-Vázquez, Gonzalo; Makarova, Julia; Makarov, Valeri A; Herreras, Oscar

2016-01-01

It is unclear whether the two hippocampal lobes convey similar or different activities and how they cooperate. Spatial discrimination of electric fields in anesthetized rats allowed us to compare the pathway-specific field potentials corresponding to the gamma-paced CA3 output (CA1 Schaffer potentials) and CA3 somatic inhibition within and between sides. Bilateral excitatory Schaffer gamma waves are generally larger and lead from the right hemisphere with only moderate covariation of amplitude, and drive CA1 pyramidal units more strongly than unilateral waves. CA3 waves lock to the ipsilateral Schaffer potentials, although bilateral coherence was weak. Notably, Schaffer activity may run laterally, as seen after the disruption of the connecting pathways. Thus, asymmetric operations promote the entrainment of CA3-autonomous gamma oscillators bilaterally, synchronizing lateralized gamma strings to converge optimally on CA1 targets. The findings support the view that interhippocampal connections integrate different aspects of information that flow through the left and right lobes. DOI: http://dx.doi.org/10.7554/eLife.16658.001 PMID:27599221

20 Years of persistent identifiers - Which systems are here to stay?

NASA Astrophysics Data System (ADS)

Klump, Jens; Huber, Robert; Lehnert, Kerstin

2016-04-01

Web-based persistent identifiers have been around for more than 20 years, a period long enough to start observing patterns of success and failure. Persistent identifiers were invented to address challenges arising from the distributed and disorganised nature of the internet, which not only allowed new technologies to emerge, it also made it difficult to maintain a persistent record of science. Persistent identifiers now allow unambiguous identification of resources on the net. The expectations were that persistent identifiers would lead to greater accessibility, transparency and reproducibility of research results. Over the past two decades a number of persistent identifier systems have been built, one of them being Digital Object Identifiers (DOI). While DOI were originally invented by the publishing industry, they quickly became an established way for the identification of research resources. At first, these resources referred to scholarly literature and related resources. Other identifier systems, some of them using DOI as an example, were developed as grass-roots efforts by the scientific community. The concept of using persistent identifiers has since been expanded to other, non-textual resources, like datasets (DOI, EPIC) and geological specimens (IGSN), and more recently to authors and contributors of scholarly works (ORCID), and to software and instruments. A common witticism states that "a great thing about standards is that there are so many to choose from." Setting up identifier systems is technically trivial. The real challenge lies in creating a governance system for the respective identifiers. Which systems will stand the test of time? Drawing on data from the Registry of Research Data Repositories (re3data.org) and our own experience in the field, this presentation looks at the history and adoption of existing identifier systems and how this gives us some indications towards factors influencing sustainability of these systems.

The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles.

PubMed

Piwowar, Heather; Priem, Jason; Larivière, Vincent; Alperin, Juan Pablo; Matthias, Lisa; Norlander, Bree; Farley, Ashley; West, Jevin; Haustein, Stefanie

2018-01-01

Despite growing interest in Open Access (OA) to scholarly literature, there is an unmet need for large-scale, up-to-date, and reproducible studies assessing the prevalence and characteristics of OA. We address this need using oaDOI, an open online service that determines OA status for 67 million articles. We use three samples, each of 100,000 articles, to investigate OA in three populations: (1) all journal articles assigned a Crossref DOI, (2) recent journal articles indexed in Web of Science, and (3) articles viewed by users of Unpaywall, an open-source browser extension that lets users find OA articles using oaDOI. We estimate that at least 28% of the scholarly literature is OA (19M in total) and that this proportion is growing, driven particularly by growth in Gold and Hybrid. The most recent year analyzed (2015) also has the highest percentage of OA (45%). Because of this growth, and the fact that readers disproportionately access newer articles, we find that Unpaywall users encounter OA quite frequently: 47% of articles they view are OA. Notably, the most common mechanism for OA is not Gold, Green, or Hybrid OA, but rather an under-discussed category we dub Bronze: articles made free-to-read on the publisher website, without an explicit Open license. We also examine the citation impact of OA articles, corroborating the so-called open-access citation advantage: accounting for age and discipline, OA articles receive 18% more citations than average, an effect driven primarily by Green and Hybrid OA. We encourage further research using the free oaDOI service, as a way to inform OA policy and practice.

The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles

PubMed Central

Larivière, Vincent; Alperin, Juan Pablo; Matthias, Lisa; Norlander, Bree; Farley, Ashley; West, Jevin; Haustein, Stefanie

2018-01-01

Despite growing interest in Open Access (OA) to scholarly literature, there is an unmet need for large-scale, up-to-date, and reproducible studies assessing the prevalence and characteristics of OA. We address this need using oaDOI, an open online service that determines OA status for 67 million articles. We use three samples, each of 100,000 articles, to investigate OA in three populations: (1) all journal articles assigned a Crossref DOI, (2) recent journal articles indexed in Web of Science, and (3) articles viewed by users of Unpaywall, an open-source browser extension that lets users find OA articles using oaDOI. We estimate that at least 28% of the scholarly literature is OA (19M in total) and that this proportion is growing, driven particularly by growth in Gold and Hybrid. The most recent year analyzed (2015) also has the highest percentage of OA (45%). Because of this growth, and the fact that readers disproportionately access newer articles, we find that Unpaywall users encounter OA quite frequently: 47% of articles they view are OA. Notably, the most common mechanism for OA is not Gold, Green, or Hybrid OA, but rather an under-discussed category we dub Bronze: articles made free-to-read on the publisher website, without an explicit Open license. We also examine the citation impact of OA articles, corroborating the so-called open-access citation advantage: accounting for age and discipline, OA articles receive 18% more citations than average, an effect driven primarily by Green and Hybrid OA. We encourage further research using the free oaDOI service, as a way to inform OA policy and practice. PMID:29456894

Depth of interaction decoding of a continuous crystal detector module.

PubMed

Ling, T; Lewellen, T K; Miyaoka, R S

2007-04-21

We present a clustering method to extract the depth of interaction (DOI) information from an 8 mm thick crystal version of our continuous miniature crystal element (cMiCE) small animal PET detector. This clustering method, based on the maximum-likelihood (ML) method, can effectively build look-up tables (LUT) for different DOI regions. Combined with our statistics-based positioning (SBP) method, which uses a LUT searching algorithm based on the ML method and two-dimensional mean-variance LUTs of light responses from each photomultiplier channel with respect to different gamma ray interaction positions, the position of interaction and DOI can be estimated simultaneously. Data simulated using DETECT2000 were used to help validate our approach. An experiment using our cMiCE detector was designed to evaluate the performance. Two and four DOI region clustering were applied to the simulated data. Two DOI regions were used for the experimental data. The misclassification rate for simulated data is about 3.5% for two DOI regions and 10.2% for four DOI regions. For the experimental data, the rate is estimated to be approximately 25%. By using multi-DOI LUTs, we also observed improvement of the detector spatial resolution, especially for the corner region of the crystal. These results show that our ML clustering method is a consistent and reliable way to characterize DOI in a continuous crystal detector without requiring any modifications to the crystal or detector front end electronics. The ability to characterize the depth-dependent light response function from measured data is a major step forward in developing practical detectors with DOI positioning capability.

Integrating Health into Local Climate Response: Lessons from the U.S. CDC Climate-Ready States and Cities Initiative

PubMed Central

Fox, Mary A.; Kaye, Charlotte; Resnick, Beth

2017-01-01

Summary: Public health has potential to serve as a frame to convey the urgency of behavior change needed to adapt to a changing climate and reduce greenhouse gas emissions. Local governments form the backbone of climate-related public health preparedness. Yet local health agencies are often inadequately prepared and poorly integrated into climate change assessments and plans. We reviewed the climate health profiles of 16 states and two cities participating in the U.S. Centers for Disease Control and Prevention (CDC)’s Climate-Ready States and Cities Initiative (CRSCI) that aims to build local capacity to assess and respond to the health impacts of climate change. Following recommendations from a recent expert panel strategic review, we present illustrations of emerging promising practice and future directions. We found that CRSCI has strengthened climate preparedness and response in local public health agencies by identifying critical climate-health impacts and vulnerable populations, and has helped integrate health more fully into broader climate planning. Promising practice was found in all three recommendation areas identified by the expert panel (leveraging partnerships, refining assessment methodologies and enhancing communications), particularly with regard to health impacts of extreme heat. Vast needs remain, however, suggesting the need to disseminate CRSCI experience to non-grantees. In conclusion, the CRSCI program approach and selected activities illustrate a way forward toward robust, targeted local preparedness and response that may serve as a useful example for public health departments in the United States and internationally, particularly at a time of uncertain commitment to climate change agreements at the national level. https://doi.org/10.1289/EHP1838 PMID:28934724

Evolution of NASA's Earth Science Digital Object Identifier Registration System

NASA Technical Reports Server (NTRS)

Wanchoo, Lalit; James, Nathan

2017-01-01

NASA's Earth Science Data and Information System (ESDIS) Project has implemented a fully automated system for assigning Digital Object Identifiers (DOIs) to Earth Science data products being managed by its network of 12 distributed active archive centers (DAACs). A key factor in the successful evolution of the DOI registration system over last 7 years has been the incorporation of community input from three focus groups under the NASA's Earth Science Data System Working Group (ESDSWG). These groups were largely composed of DOI submitters and data curators from the 12 data centers serving the user communities of various science disciplines. The suggestions from these groups were formulated into recommendations for ESDIS consideration and implementation. The ESDIS DOI registration system has evolved to be fully functional with over 5,000 publicly accessible DOIs and over 200 DOIs being held in reserve status until the information required for registration is obtained. The goal is to assign DOIs to the entire 8000+ data collections under ESDIS management via its network of discipline-oriented data centers. DOIs make it easier for researchers to discover and use earth science data and they enable users to provide valid citations for the data they use in research. Also for the researcher wishing to reproduce the results presented in science publications, the DOI can be used to locate the exact data or data products being cited.

Trend-Analysis of Solid-State Structures: Low-Energy Conformational 'Reactions' Involving Directed and Coupled Movements in Half-Sandwich Compounds [CpFe(CO){C(=O)R}PPh3].

PubMed

Brunner, Henri; Tsuno, Takashi

2018-05-01

Invited for this month's cover picture are Prof. Dr. Henri Brunner from the University of Regensburg (Germany) and Prof. Dr. Takashi Tsuno from Nihon University (Japan). The cover picture shows the conformational reaction of JIDLUD→FIHTUL. The order of sample points of solid-state structures reveals information concerning low-energy, directed, and coupled movements in molecules. Read the full text of their Communication at https://doi.org/10.1002/open.201800007.

43 CFR 17.301 - What is the purpose of DOI's age discrimination regulations?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What is the purpose of DOI's age... Age General § 17.301 What is the purpose of DOI's age discrimination regulations? The purpose of these regulations is to set out DOI's policies and procedures under the Age Discrimination Act of 1975 and the...

41 CFR 102-75.670 - What responsibilities does DOI have after receiving the disposal agency's assignment letter?

Code of Federal Regulations, 2010 CFR

2010-07-01

... does DOI have after receiving the disposal agency's assignment letter? 102-75.670 Section 102-75.670... Property for Use As Public Park Or Recreation Areas § 102-75.670 What responsibilities does DOI have after..., the Secretary may proceed with the transfer. DOI must take all necessary actions to accomplish the...

30 CFR 250.1006 - How must I decommission and take out of service a DOI pipeline?

Code of Federal Regulations, 2010 CFR

2010-07-01

... a DOI pipeline? 250.1006 Section 250.1006 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... and Pipeline Rights-of-Way § 250.1006 How must I decommission and take out of service a DOI pipeline...) The table in this section lists the requirements if you take a DOI pipeline out of service: If you...

43 CFR 45.25 - What will DOI do with any hearing requests?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What will DOI do with any hearing requests... PRESCRIPTIONS IN FERC HYDROPOWER LICENSES Hearing Process Initiation of Hearing Process § 45.25 What will DOI do... will refer the case for a hearing as follows: (1) If the hearing is to be conducted by DOI, OEPC will...

41 CFR 102-75.650 - When must DOI request assignment of the property?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false When must DOI request...-75.650 When must DOI request assignment of the property? Within 30 calendar days after the expiration of the 30-calendar day period specified in § 102-75.640, DOI must submit to the disposal agency an...

41 CFR 102-75.670 - What responsibilities does DOI have after receiving the disposal agency's assignment letter?

Code of Federal Regulations, 2011 CFR

2011-01-01

... does DOI have after receiving the disposal agency's assignment letter? 102-75.670 Section 102-75.670... Property for Use As Public Park Or Recreation Areas § 102-75.670 What responsibilities does DOI have after..., the Secretary may proceed with the transfer. DOI must take all necessary actions to accomplish the...

43 CFR 17.301 - What is the purpose of DOI's age discrimination regulations?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false What is the purpose of DOI's age... Age General § 17.301 What is the purpose of DOI's age discrimination regulations? The purpose of these regulations is to set out DOI's policies and procedures under the Age Discrimination Act of 1975 and the...

43 CFR 45.25 - What will DOI do with any hearing requests?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false What will DOI do with any hearing requests... PRESCRIPTIONS IN FERC HYDROPOWER LICENSES Hearing Process Initiation of Hearing Process § 45.25 What will DOI do... will refer the case for a hearing as follows: (1) If the hearing is to be conducted by DOI, OEPC will...

41 CFR 102-75.650 - When must DOI request assignment of the property?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false When must DOI request...-75.650 When must DOI request assignment of the property? Within 30 calendar days after the expiration of the 30-calendar day period specified in § 102-75.640, DOI must submit to the disposal agency an...

Perme Intensive Care Unit Mobility Score and ICU Mobility Scale: translation into Portuguese and cross-cultural adaptation for use in Brazil.

PubMed

Kawaguchi, Yurika Maria Fogaça; Nawa, Ricardo Kenji; Figueiredo, Thais Borgheti; Martins, Lourdes; Pires-Neto, Ruy Camargo

2016-01-01

To translate the Perme Intensive Care Unit Mobility Score and the ICU Mobility Scale (IMS) into Portuguese, creating versions that are cross-culturally adapted for use in Brazil, and to determine the interobserver agreement and reliability for both versions. The processes of translation and cross-cultural validation consisted in the following: preparation, translation, reconciliation, synthesis, back-translation, review, approval, and pre-test. The Portuguese-language versions of both instruments were then used by two researchers to evaluate critically ill ICU patients. Weighted kappa statistics and Bland-Altman plots were used in order to verify interobserver agreement for the two instruments. In each of the domains of the instruments, interobserver reliability was evaluated with Cronbach's alpha coefficient. The correlation between the instruments was assessed by Spearman's correlation test. The study sample comprised 103 patients-56 (54%) of whom were male-with a mean age of 52 ± 18 years. The main reason for ICU admission (in 44%) was respiratory failure. Both instruments showed excellent interobserver agreement ( > 0.90) and reliability ( > 0.90) in all domains. Interobserver bias was low for the IMS and the Perme Score (-0.048 ± 0.350 and -0.06 ± 0.73, respectively). The 95% CIs for the same instruments ranged from -0.73 to 0.64 and -1.50 to 1.36, respectively. There was also a strong positive correlation between the two instruments (r = 0.941; p < 0.001). In their versions adapted for use in Brazil, both instruments showed high interobserver agreement and reliability. Realizar a tradução e a validação cultural para a língua portuguesa falada no Brasil e determinar a concordância e a confiabilidade dos instrumentos Perme Intensive Care Unit Mobility Score (designado Perme Escore) e ICU Mobility Scale (designada Escala de Mobilidade em UTI, EMU). Os processos de tradução e adaptação cultural seguiram as seguintes etapas: preparação, tradução, reconciliação, síntese, tradução reversa, revisão, aprovação e pré-teste. Após esses processos, as versões em português dos dois instrumentos foram utilizadas por dois pesquisadores na avaliação de pacientes críticos em UTI. O índice kappa ponderado e a disposição gráfica de Bland-Altman foram utilizados para verificar a concordância entre os instrumentos. O coeficiente alfa de Cronbach foi utilizado para verificar a confiabilidade entre as respostas dos avaliadores dentro de cada domínio dos instrumentos. A correlação entre os instrumentos foi verificada pelo teste de correlação de Spearman. A amostra foi composta por 103 pacientes, sendo a maioria homens (n = 56; 54%), com média de idade = 52 ± 18 anos. O principal motivo de internação nas UTIs foi insuficiência respiratória (em 44%). Os dois instrumentos apresentaram excelente concordância interobservador (> 0,90) e confiabilidade ( > 0,90) em todos os domínios. Constatou-se um baixo viés interobservador na EMU e no Perme Escore (-0,048 ± 0,350 e -0,06 ± 0,73, respectivamente). Os IC95% para os mesmos instrumentos variaram, respectivamente, de -0,73 a 0,64 e de -1,50 a 1,36, respectivamente. Além disso, verificou-se alta correlação positiva entre os dois instrumentos (r = 0,941; p < 0,001). As versões dos dois instrumentos apresentaram alta concordância e confiabilidade interobservador.

Global stability of steady states in the classical Stefan problem for general boundary shapes

PubMed Central

Hadžić, Mahir; Shkoller, Steve

2015-01-01

The classical one-phase Stefan problem (without surface tension) allows for a continuum of steady-state solutions, given by an arbitrary (but sufficiently smooth) domain together with zero temperature. We prove global-in-time stability of such steady states, assuming a sufficient degree of smoothness on the initial domain, but without any a priori restriction on the convexity properties of the initial shape. This is an extension of our previous result (Hadžić & Shkoller 2014 Commun. Pure Appl. Math. 68, 689–757 (doi:10.1002/cpa.21522)) in which we studied nearly spherical shapes. PMID:26261359

Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness

PubMed Central

Akeju, Oluwaseun; Loggia, Marco L; Catana, Ciprian; Pavone, Kara J; Vazquez, Rafael; Rhee, James; Contreras Ramirez, Violeta; Chonde, Daniel B; Izquierdo-Garcia, David; Arabasz, Grae; Hsu, Shirley; Habeeb, Kathleen; Hooker, Jacob M; Napadow, Vitaly; Brown, Emery N; Purdon, Patrick L

2014-01-01

Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness and recovery using the α2-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate of glucose and cerebral blood flow were preferentially decreased in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs). Cortico-cortical functional connectivity within the DMN and FPNs was preserved. However, DMN thalamo-cortical functional connectivity was disrupted. Recovery from this state was associated with sustained reduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity. We report that loss of thalamo-cortical functional connectivity is sufficient to produce unconsciousness. DOI: http://dx.doi.org/10.7554/eLife.04499.001 PMID:25432022

Female mice ultrasonically interact with males during courtship displays

PubMed Central

Neunuebel, Joshua P; Taylor, Adam L; Arthur, Ben J; Egnor, SE Roian

2015-01-01

During courtship males attract females with elaborate behaviors. In mice, these displays include ultrasonic vocalizations. Ultrasonic courtship vocalizations were previously attributed to the courting male, despite evidence that both sexes produce virtually indistinguishable vocalizations. Because of this similarity, and the difficulty of assigning vocalizations to individuals, the vocal contribution of each individual during courtship is unknown. To address this question, we developed a microphone array system to localize vocalizations from socially interacting, individual adult mice. With this system, we show that female mice vocally interact with males during courtship. Males and females jointly increased their vocalization rates during chases. Furthermore, a female's participation in these vocal interactions may function as a signal that indicates a state of increased receptivity. Our results reveal a novel form of vocal communication during mouse courtship, and lay the groundwork for a mechanistic dissection of communication during social behavior. DOI: http://dx.doi.org/10.7554/eLife.06203.001 PMID:26020291

Mapping global environmental suitability for Zika virus

PubMed Central

Messina, Jane P; Kraemer, Moritz UG; Brady, Oliver J; Pigott, David M; Shearer, Freya M; Weiss, Daniel J; Golding, Nick; Ruktanonchai, Corrine W; Gething, Peter W; Cohn, Emily; Brownstein, John S; Khan, Kamran; Tatem, Andrew J; Jaenisch, Thomas; Murray, Christopher JL; Marinho, Fatima; Scott, Thomas W; Hay, Simon I

2016-01-01

Zika virus was discovered in Uganda in 1947 and is transmitted by Aedes mosquitoes, which also act as vectors for dengue and chikungunya viruses throughout much of the tropical world. In 2007, an outbreak in the Federated States of Micronesia sparked public health concern. In 2013, the virus began to spread across other parts of Oceania and in 2015, a large outbreak in Latin America began in Brazil. Possible associations with microcephaly and Guillain-Barré syndrome observed in this outbreak have raised concerns about continued global spread of Zika virus, prompting its declaration as a Public Health Emergency of International Concern by the World Health Organization. We conducted species distribution modelling to map environmental suitability for Zika. We show a large portion of tropical and sub-tropical regions globally have suitable environmental conditions with over 2.17 billion people inhabiting these areas. DOI: http://dx.doi.org/10.7554/eLife.15272.001 PMID:27090089

Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

PubMed Central

Kuzmanic, Antonija; Sutto, Ludovico; Saladino, Giorgio; Nebreda, Angel R; Gervasio, Francesco L; Orozco, Modesto

2017-01-01

p38α is a Ser/Thr protein kinase involved in a variety of cellular processes and pathological conditions, which makes it a promising pharmacological target. Although the activity of the enzyme is highly regulated, its molecular mechanism of activation remains largely unexplained, even after decades of research. By using state-of-the-art molecular dynamics simulations, we decipher the key elements of the complex molecular mechanism refined by evolution to allow for a fine tuning of p38α kinase activity. Our study describes for the first time the molecular effects of different regulators of the enzymatic activity, and provides an integrative picture of the activation mechanism that explains the seemingly contradictory X-ray and NMR data. DOI: http://dx.doi.org/10.7554/eLife.22175.001 PMID:28445123

Role of competition between polarity sites in establishing a unique front

PubMed Central

Wu, Chi-Fang; Chiou, Jian-Geng; Minakova, Maria; Woods, Benjamin; Tsygankov, Denis; Zyla, Trevin R; Savage, Natasha S; Elston, Timothy C; Lew, Daniel J

2015-01-01

Polarity establishment in many cells is thought to occur via positive feedback that reinforces even tiny asymmetries in polarity protein distribution. Cdc42 and related GTPases are activated and accumulate in a patch of the cortex that defines the front of the cell. Positive feedback enables spontaneous polarization triggered by stochastic fluctuations, but as such fluctuations can occur at multiple locations, how do cells ensure that they make only one front? In polarizing cells of the model yeast Saccharomyces cerevisiae, positive feedback can trigger growth of several Cdc42 clusters at the same time, but this multi-cluster stage rapidly evolves to a single-cluster state, which then promotes bud emergence. By manipulating polarity protein dynamics, we show that resolution of multi-cluster intermediates occurs through a greedy competition between clusters to recruit and retain polarity proteins from a shared intracellular pool. DOI: http://dx.doi.org/10.7554/eLife.11611.001 PMID:26523396

Perception as a closed-loop convergence process

PubMed Central

Ahissar, Ehud; Assa, Eldad

2016-01-01

Perception of external objects involves sensory acquisition via the relevant sensory organs. A widely-accepted assumption is that the sensory organ is the first station in a serial chain of processing circuits leading to an internal circuit in which a percept emerges. This open-loop scheme, in which the interaction between the sensory organ and the environment is not affected by its concurrent downstream neuronal processing, is strongly challenged by behavioral and anatomical data. We present here a hypothesis in which the perception of external objects is a closed-loop dynamical process encompassing loops that integrate the organism and its environment and converging towards organism-environment steady-states. We discuss the consistency of closed-loop perception (CLP) with empirical data and show that it can be synthesized in a robotic setup. Testable predictions are proposed for empirical distinction between open and closed loop schemes of perception. DOI: http://dx.doi.org/10.7554/eLife.12830.001 PMID:27159238

Airflow and optic flow mediate antennal positioning in flying honeybees

PubMed Central

Roy Khurana, Taruni; Sane, Sanjay P

2016-01-01

To maintain their speeds during navigation, insects rely on feedback from their visual and mechanosensory modalities. Although optic flow plays an essential role in speed determination, it is less reliable under conditions of low light or sparse landmarks. Under such conditions, insects rely on feedback from antennal mechanosensors but it is not clear how these inputs combine to elicit flight-related antennal behaviours. We here show that antennal movements of the honeybee, Apis mellifera, are governed by combined visual and antennal mechanosensory inputs. Frontal airflow, as experienced during forward flight, causes antennae to actively move forward as a sigmoidal function of absolute airspeed values. However, corresponding front-to-back optic flow causes antennae to move backward, as a linear function of relative optic flow, opposite the airspeed response. When combined, these inputs maintain antennal position in a state of dynamic equilibrium. DOI: http://dx.doi.org/10.7554/eLife.14449.001 PMID:27097104

Carbon nanoparticle doped micro-patternable nano-composites for wearable sensing applications (Conference Presentation)

NASA Astrophysics Data System (ADS)

Khosla, Ajit

2017-04-01

This talk focuses on preparation, characterization and micropatterning of electrically conducting KETJENBLACK carbon black nanoparticle (80 nm-diameter) doped Polydimethylsiloxane (PDMS) by employing extrusion mixing. Previously, we had reported fabrication of various micropatternable nanocomposites for wearable sensing applications vis solvent assisted ultrasonic mixing technique[1-16] . Extrusion mixing has an advantage as no organic solvents are used and homogenous dispersion of carbon nanoparticles is observed, which is confirmed by SEM analysis. The developed nanocomposite can be micropatterened using standard microfabrication techniques. It is also observed that percolation threshold occurs at 0.51 wt% of carbon nanoparticles in polymer matrix. Examples of developed nano-composites for wearable sensing applications for precision medicine will also be discussed. References: 1.http://summit.sfu.ca/item/12017 A. Khosla. Micropatternable multifunctional nanocomposite polymers for flexible soft MEMS applications. Diss. Applied Science: School of Engineering Science, 2011. 2. A. Khosla ; B. L. Gray; Fabrication of multiwalled carbon nanotube polydimethylsiloxne nanocomposite polymer flexible microelectrodes for microfluidics and MEMS. Proc. SPIE 7642, Electroactive Polymer Actuators and Devices (EAPAD) 2010, 76421V (April 09, 2010); doi:10.1117/12.847292. 3. Ang Li ; Ajit Khosla ; Connie Drewbrook ; Bonnie L. Gray; Fabrication and testing of thermally responsive hydrogel-based actuators using polymer heater elements for flexible microvalves. Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290G (February 14, 2011); doi:10.1117/12.873197. 4. Khosla, A. and Gray, B. L. (2010), Preparation, Micro-Patterning and Electrical Characterization of Functionalized Carbon-Nanotube Polydimethylsiloxane Nanocomposite Polymer. Macromol. Symp., 297: 210-218. doi:10.1002/masy.200900165 5. A. Khosla ; D. Hilbich ; C. Drewbrook ; D. Chung ; B. L. Gray; Large scale micropatterning of multi-walled carbon nanotube/polydimethylsiloxane nanocomposite polymer on highly flexible 12×24 inch substrates. Proc. SPIE 7926, Micromachining and Microfabrication Process Technology XVI, 79260L (February 15, 2011); doi:10.1117/12.876738. 6. A. Khosla, and Bonnie L. Gray. "(Invited) Micropatternable Multifunctional Nanocomposite Polymers for Flexible Soft NEMS and MEMS Applications." ECS Transactions 45.3 (2012): 477-494. doi: 10.1149/1.3700913 7. Khosla, Ajit. "Nanoparticle-doped electrically-conducting polymers for flexible nano-micro Systems." Electrochemical Society Interface 21.3-4 (2012): 67-70. 8. Ajit Khosla; Smart garments in chronic disease management: progress and challenges. Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482O (October 24, 2012); doi:10.1117/12.979667. 9. D. Chung ; A. Khosla ; B. L. Gray; Screen printable flexible conductive nanocomposite polymer with applications to wearable sensors. Proc. SPIE 9060, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2014, 90600U (April 16, 2014); doi:10.1117/12.2046548. 10. Daehan Chung ; Sam Seyfollahi ; Ajit Khosla ; Bonnie Gray ; Ash Parameswaran ; Ramani Ramaseshan ; Kirpal Kohli; Initial experiments with flexible conductive electrodes for potential applications in cancer tissue screening. Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290Z (February 14, 2011); doi:10.1117/12.875563. 11. A. Khosla ; B. L. Gray; New technologies for large-scale micropatterning of functional nanocomposite polymers. Proc. SPIE 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012, 83440W (April 26, 2012); doi:10.1117/12.915178. 12. A. Khosla, B.L. Gray, Preparation, characterization and micromolding of multi-walled carbon nanotube polydimethylsiloxane conducting nanocomposite polymer, Materials Letters, Volume 63, Issues 13-14, 31 May 2009, Pages 1203-1206, ISSN 0167-577X, http://dx.doi.org/10.1016/j.matlet.2009.02.043. 13. Giassa, M., Khosla, A., Gray, B. et al. J Electron Test (2010) 26: 139. doi:10.1007/s10836-009-5125-3 14.Ozhikandathil, Jayan, Ajit Khosla, and Muthukumaran Packirisamy. "Electrically Conducting PDMS Nanocomposite Using In Situ Reduction of Gold Nanostructures and Mechanical Stimulation of Carbon Nanotubes and Silver Nanoparticles." ECS Journal of Solid State Science and Technology 4.10 (2015): S3048-S3052. doi:10.1149/2.0091510jss 15. Kassegne, Sam, Maria Vomero, Roberto Gavuglio, Mieko Hirabayashi, Emre Özyilmaz, Sebastien Nguyen, Jesus Rodriguez, Eda Özyilmaz, Pieter van Niekerk, and Ajit Khosla. "Electrical impedance, electrochemistry, mechanical stiffness, and hardness tunability in glassy carbon MEMS μECoG electrodes." Microelectronic Engineering 133 (2015): 36-44. 16. A. Khosla ; B. L. Gray; Fabrication and properties of conductive micromoldable thermosetting polymer for electronic routing in highly flexible microfluidic systems. Proc. SPIE 7593, Microfluidics, BioMEMS, and Medical Microsystems VIII, 759314 (February 17, 2010); doi:10.1117/12.840911.

Spin-Orbit-Enhanced Functionality in LaAlO3/SrTiO3 Nanostructures

DTIC Science & Technology

2015-09-16

34 J. Vis. Exp. 89 , e51886 (2014). http://dx.doi.org/doi:10.3791/51886 J. A. Sulpizio, S. Ilani, P. Irvin, and J. Levy, "Nanoscale Phenomena in Oxide... 89 , e51886 (2014). http://dx.doi.org/doi:10.3791/51886 J. A. Sulpizio, S. Ilani, P. Irvin, and J. Levy, "Nanoscale Phenomena in Oxide

41 CFR 102-75.640 - When must DOI notify the disposal agency that an eligible applicant is interested in acquiring...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false When must DOI notify the... Disposal Property for Use As Public Park Or Recreation Areas § 102-75.640 When must DOI notify the disposal agency that an eligible applicant is interested in acquiring the property? DOI must notify the disposal...

Keeping it wild: an interagency strategy to monitor trends in wilderness character across the National Wilderness Preservation System

Treesearch

Peter Landres; Chris Barns; John G. Dennis; Tim Devine; Paul Geissler; Curtis S. McCasland; Linda Merigliano; Justin Seastrand; Ralph Swain

2008-01-01

The Interagency Wilderness Character Monitoring Team--representing the Department of the Interior (DOI) Bureau of Land Management, DOI Fish and Wildlife Service, DOI National Park Service, DOI U.S. Geological Survey, and the U.S. Forest Service-offers in this document an interagency strategy to monitor trends in wilderness character across the National Wilderness...

41 CFR 102-75.660 - What happens if DOI does not approve any applications or does not submit an assignment...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What happens if DOI does... Disposal Property for Use As Public Park Or Recreation Areas § 102-75.660 What happens if DOI does not approve any applications or does not submit an assignment recommendation? If DOI does not approve any...

41 CFR 102-75.640 - When must DOI notify the disposal agency that an eligible applicant is interested in acquiring...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false When must DOI notify the... Disposal Property for Use As Public Park Or Recreation Areas § 102-75.640 When must DOI notify the disposal agency that an eligible applicant is interested in acquiring the property? DOI must notify the disposal...

Use of internal scintillator radioactivity to calibrate DOI function of a PET detector with a dual-ended-scintillator readout

PubMed Central

Bircher, Chad; Shao, Yiping

2012-01-01

Purpose: Positron emission tomography (PET) detectors that use a dual-ended-scintillator readout to measure depth-of-interaction (DOI) must have an accurate DOI function to provide the relationship between DOI and signal ratios to be used for detector calibration and recalibration. In a previous study, the authors used a novel and simple method to accurately and quickly measure DOI function by irradiating the detector with an external uniform flood source; however, as a practical concern, implementing external uniform flood sources in an assembled PET system is technically challenging and expensive. In the current study, therefore, the authors investigated whether the same method could be used to acquire DOI function from scintillator-generated (i.e., internal) radiation. The authors also developed a method for calibrating the energy scale necessary to select the events within the desired energy window. Methods: The authors measured the DOI function of a PET detector with lutetium yttrium orthosilicate (LYSO) scintillators. Radiation events originating from the scintillators’ internal Lu-176 beta decay were used to measure DOI functions which were then compared with those measured from both an external uniform flood source and an electronically collimated external point source. The authors conducted these studies with several scintillators of differing geometries (1.5 × 1.5 and 2.0 × 2.0 mm2 cross-section area and 20, 30, and 40 mm length) and various surface finishes (mirror-finishing, saw-cut rough, and other finishes in between), and in a prototype array. Results: All measured results using internal and external radiation sources showed excellent agreement in DOI function measurement. The mean difference among DOI values for all scintillators measured from internal and external radiation sources was less than 1.0 mm for different scintillator geometries and various surface finishes. Conclusions: The internal radioactivity of LYSO scintillators can be used to accurately measure DOI function in PET detectors, regardless of scintillator geometry or surface finish. Because an external radiation source is not needed, this method of DOI function measurement can be practically applied to individual PET detectors as well as assembled systems. PMID:22320787

Use of internal scintillator radioactivity to calibrate DOI function of a PET detector with a dual-ended-scintillator readout.

PubMed

Bircher, Chad; Shao, Yiping

2012-02-01

Positron emission tomography (PET) detectors that use a dual-ended-scintillator readout to measure depth-of-interaction (DOI) must have an accurate DOI function to provide the relationship between DOI and signal ratios to be used for detector calibration and recalibration. In a previous study, the authors used a novel and simple method to accurately and quickly measure DOI function by irradiating the detector with an external uniform flood source; however, as a practical concern, implementing external uniform flood sources in an assembled PET system is technically challenging and expensive. In the current study, therefore, the authors investigated whether the same method could be used to acquire DOI function from scintillator-generated (i.e., internal) radiation. The authors also developed a method for calibrating the energy scale necessary to select the events within the desired energy window. The authors measured the DOI function of a PET detector with lutetium yttrium orthosilicate (LYSO) scintillators. Radiation events originating from the scintillators' internal Lu-176 beta decay were used to measure DOI functions which were then compared with those measured from both an external uniform flood source and an electronically collimated external point source. The authors conducted these studies with several scintillators of differing geometries (1.5 × 1.5 and 2.0 × 2.0 mm(2) cross-section area and 20, 30, and 40 mm length) and various surface finishes (mirror-finishing, saw-cut rough, and other finishes in between), and in a prototype array. All measured results using internal and external radiation sources showed excellent agreement in DOI function measurement. The mean difference among DOI values for all scintillators measured from internal and external radiation sources was less than 1.0 mm for different scintillator geometries and various surface finishes. The internal radioactivity of LYSO scintillators can be used to accurately measure DOI function in PET detectors, regardless of scintillator geometry or surface finish. Because an external radiation source is not needed, this method of DOI function measurement can be practically applied to individual PET detectors as well as assembled systems.

Use of internal scintillator radioactivity to calibrate DOI function of a PET detector with a dual-ended-scintillator readout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bircher, Chad; Shao Yiping

Purpose: Positron emission tomography (PET) detectors that use a dual-ended-scintillator readout to measure depth-of-interaction (DOI) must have an accurate DOI function to provide the relationship between DOI and signal ratios to be used for detector calibration and recalibration. In a previous study, the authors used a novel and simple method to accurately and quickly measure DOI function by irradiating the detector with an external uniform flood source; however, as a practical concern, implementing external uniform flood sources in an assembled PET system is technically challenging and expensive. In the current study, therefore, the authors investigated whether the same method couldmore » be used to acquire DOI function from scintillator-generated (i.e., internal) radiation. The authors also developed a method for calibrating the energy scale necessary to select the events within the desired energy window. Methods: The authors measured the DOI function of a PET detector with lutetium yttrium orthosilicate (LYSO) scintillators. Radiation events originating from the scintillators' internal Lu-176 beta decay were used to measure DOI functions which were then compared with those measured from both an external uniform flood source and an electronically collimated external point source. The authors conducted these studies with several scintillators of differing geometries (1.5 x 1.5 and 2.0 x 2.0 mm{sup 2} cross-section area and 20, 30, and 40 mm length) and various surface finishes (mirror-finishing, saw-cut rough, and other finishes in between), and in a prototype array. Results: All measured results using internal and external radiation sources showed excellent agreement in DOI function measurement. The mean difference among DOI values for all scintillators measured from internal and external radiation sources was less than 1.0 mm for different scintillator geometries and various surface finishes. Conclusions: The internal radioactivity of LYSO scintillators can be used to accurately measure DOI function in PET detectors, regardless of scintillator geometry or surface finish. Because an external radiation source is not needed, this method of DOI function measurement can be practically applied to individual PET detectors as well as assembled systems.« less

Fine Structure of Trious and Excitons in Single GaAs Quantum Dots

DTIC Science & Technology

2002-08-30

RAPID COMMUNICATIONS PHYSICAL REVIEW B 66, 081310~R! ~2002!Fine structure of trions and excitons in single GaAs quantum dots J. G. Tischler, A. S ...fine structure of single localized excitons and trions. DOI: 10.1103/PhysRevB.66.081310 PACS number~ s !: 78.67.Hc, 73.21.2b, 71.35.2yAlthough the...AUTHOR( S ) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Research Laboratory

Double-difference tomography velocity structure in Northern Oklahoma: Evidence for reduced basement velocity in the Nemaha Uplift

NASA Astrophysics Data System (ADS)

Stevens, N. T.; Keranen, K. M.; Lambert, C.

2016-12-01

Induced seismicity in northern Oklahoma presents risk for infrastructure, but also an opportunity to gain new insights to earthquake processes [Petersen et al., 2016]. Here we present a double-difference tomographic study using TomoDD [Zhang and Thurber, 2003] in northern Oklahoma utilizing records from a dense broadband network over a 1-year period, constituting a catalog of over 10,000 local seismic events. We image a shallow (depth < 4 km) high-velocity structure consistent with the Nemaha uplift [Gay, 2003a], bounded by shallow, lower-velocity regions on either side, likely sedimentary strata at this depth bounding uplifted basement. Velocities within the uplift are lower than expected in subjacent crystalline basement rock (depth > 4 km). We suggest that this low velocity anomaly stems from enhanced fracturing and/or weathering of the basement in the Nemaha uplift in northern Oklahoma. This velocity anomaly is not observed in basement off the shoulders of the structure, particularly to the southeast of the Nemaha bounding fault. Enhanced fracturing, and related increases to permeability, would ease pressure migration from injection wells linked to increased seismicity in the region, and may explain the relative absence of seismicity coincident with this structure compared to it periphery. References Gay, S. Parker, J. (2003), The Nemaha Trend-A System of Compressional Thrust-Fold, Strike-Slilp Structural Features in Kansas and Oklahoma, Part 1, Shale Shak., 9-49. Petersen, M. D., C. S. Mueller, M. P. Moschetti, S. M. Hoover, A. L. Llenos, W. L. Ellsworth, A. J. Michael, J. L. Rubinstein, A. F. McGarr, and K. S. Rukstales (2016), 2016 One-Year Seismic Hazard Forecast for the Central and Eastern United States from Induced and Natural Earthquakes, Open-File Rep., doi:10.3133/OFR20161035. Zhang, H., and C. H. Thurber (2003), Double-difference tomography: The method and its application to the Hayward Fault, California, Bull. Seismol. Soc. Am., 93(5), 1875-1889, doi:10.1785/0120020190.

A global historical data set of tropical cyclone exposure (TCE-DAT)

NASA Astrophysics Data System (ADS)

Geiger, Tobias; Frieler, Katja; Bresch, David N.

2018-01-01

Tropical cyclones pose a major risk to societies worldwide, with about 22 million directly affected people and damages of USD 29 billion on average per year over the last 20 years. While data on observed cyclones tracks (location of the center) and wind speeds are publicly available, these data sets do not contain information about the spatial extent of the storm and people or assets exposed. Here, we apply a simplified wind field model to estimate the areas exposed to wind speeds above 34, 64, and 96 knots (kn). Based on available spatially explicit data on population densities and gross domestic product (GDP) we estimate (1) the number of people and (2) the sum of assets exposed to wind speeds above these thresholds accounting for temporal changes in historical distribution of population and assets (TCE-hist) and assuming fixed 2015 patterns (TCE-2015). The associated spatially explicit and aggregated country-event-level exposure data (TCE-DAT) cover the period 1950 to 2015 and are freely available at https://doi.org/10.5880/pik.2017.011 (Geiger at al., 2017c). It is considered key information to (1) assess the contribution of climatological versus socioeconomic drivers of changes in exposure to tropical cyclones, (2) estimate changes in vulnerability from the difference in exposure and reported damages and calibrate associated damage functions, and (3) build improved exposure-based predictors to estimate higher-level societal impacts such as long-term effects on GDP, employment, or migration. We validate the adequateness of our methodology by comparing our exposure estimate to estimated exposure obtained from reported wind fields available since 1988 for the United States. We expect that the free availability of the underlying model and TCE-DAT will make research on tropical cyclone risks more accessible to non-experts and stakeholders.

Historical nitrogen fertilizer use in agricultural ecosystems of the contiguous United States during 1850-2015: application rate, timing, and fertilizer types

NASA Astrophysics Data System (ADS)

Cao, Peiyu; Lu, Chaoqun; Yu, Zhen

2018-06-01

A tremendous amount of anthropogenic nitrogen (N) fertilizer has been applied to agricultural lands to promote crop production in the US since the 1850s. However, inappropriate N management practices have caused numerous ecological and environmental problems which are difficult to quantify due to the paucity of spatially explicit time-series fertilizer use maps. Understanding and assessing N fertilizer management history could provide important implications for enhancing N use efficiency and reducing N loss. In this study, we therefore developed long-term gridded maps to depict crop-specific N fertilizer use rates, application timing, and the fractions of ammonium N (NH4+-N) and nitrate N (NO3--N) used across the contiguous US at a resolution of 5 km × 5 km during the period from 1850 to 2015. We found that N use rates in the US increased from 0.22 g N m-2 yr-1 in 1940 to 9.04 g N m-2 yr-1 in 2015. Geospatial analysis revealed that hotspots for N fertilizer use have shifted from the southeastern and eastern US to the Midwest, the Great Plains, and the Northwest over the past century. Specifically, corn in the Corn Belt region received the most intensive N input in spring, followed by the application of a large amount of N in fall, implying a high N loss risk in this region. Moreover, spatial-temporal fraction of NH4+-N and NO3--N varied largely among regions. Generally, farmers have increasingly favored ammonia N fertilizers over nitrate N fertilizers since the 1940s. The N fertilizer use data developed in this study could serve as an essential input for modeling communities to fully assess N addition impacts, and improve N management to alleviate environmental problems. Datasets used in this study are available at https://doi.org/10.1594/PANGAEA.883585.

Pulse shape discrimination and classification methods for continuous depth of interaction encoding PET detectors.

PubMed

Roncali, Emilie; Phipps, Jennifer E; Marcu, Laura; Cherry, Simon R

2012-10-21

In previous work we demonstrated the potential of positron emission tomography (PET) detectors with depth-of-interaction (DOI) encoding capability based on phosphor-coated crystals. A DOI resolution of 8 mm full-width at half-maximum was obtained for 20 mm long scintillator crystals using a delayed charge integration linear regression method (DCI-LR). Phosphor-coated crystals modify the pulse shape to allow continuous DOI information determination, but the relationship between pulse shape and DOI is complex. We are therefore interested in developing a sensitive and robust method to estimate the DOI. Here, linear discriminant analysis (LDA) was implemented to classify the events based on information extracted from the pulse shape. Pulses were acquired with 2×2×20 mm(3) phosphor-coated crystals at five irradiation depths and characterized by their DCI values or Laguerre coefficients. These coefficients were obtained by expanding the pulses on a Laguerre basis set and constituted a unique signature for each pulse. The DOI of individual events was predicted using LDA based on Laguerre coefficients (Laguerre-LDA) or DCI values (DCI-LDA) as discriminant features. Predicted DOIs were compared to true irradiation depths. Laguerre-LDA showed higher sensitivity and accuracy than DCI-LDA and DCI-LR and was also more robust to predict the DOI of pulses with higher statistical noise due to low light levels (interaction depths further from the photodetector face). This indicates that Laguerre-LDA may be more suitable to DOI estimation in smaller crystals where lower collected light levels are expected. This novel approach is promising for calculating DOI using pulse shape discrimination in single-ended readout depth-encoding PET detectors.

Pulse Shape Discrimination and Classification Methods for Continuous Depth of Interaction Encoding PET Detectors

PubMed Central

Roncali, Emilie; Phipps, Jennifer E.; Marcu, Laura; Cherry, Simon R.

2012-01-01

In previous work we demonstrated the potential of positron emission tomography (PET) detectors with depth-of-interaction (DOI) encoding capability based on phosphor-coated crystals. A DOI resolution of 8 mm full-width at half-maximum was obtained for 20 mm long scintillator crystals using a delayed charge integration linear regression method (DCI-LR). Phosphor-coated crystals modify the pulse shape to allow continuous DOI information determination, but the relationship between pulse shape and DOI is complex. We are therefore interested in developing a sensitive and robust method to estimate the DOI. Here, linear discriminant analysis (LDA) was implemented to classify the events based on information extracted from the pulse shape. Pulses were acquired with 2 × 2 × 20 mm3 phosphor-coated crystals at five irradiation depths and characterized by their DCI values or Laguerre coefficients. These coefficients were obtained by expanding the pulses on a Laguerre basis set and constituted a unique signature for each pulse. The DOI of individual events was predicted using LDA based on Laguerre coefficients (Laguerre-LDA) or DCI values (DCI-LDA) as discriminant features. Predicted DOIs were compared to true irradiation depths. Laguerre-LDA showed higher sensitivity and accuracy than DCI-LDA and DCI-LR and was also more robust to predict the DOI of pulses with higher statistical noise due to low light levels (interaction depths further from the photodetector face). This indicates that Laguerre-LDA may be more suitable to DOI estimation in smaller crystals where lower collected light levels are expected. This novel approach is promising for calculating DOI using pulse shape discrimination in single-ended readout depth-encoding PET detectors. PMID:23010690

43 CFR 17.336 - Hearings, decisions, post-termination proceedings.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-termination proceedings. Certain DOI procedural provisions applicable to title VI of the Civil Rights Act of 1964 apply to DOI's enforcement of these regulations. The procedural provisions of DOI's Title VI...

43 CFR 17.336 - Hearings, decisions, post-termination proceedings.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-termination proceedings. Certain DOI procedural provisions applicable to title VI of the Civil Rights Act of 1964 apply to DOI's enforcement of these regulations. The procedural provisions of DOI's Title VI...

43 CFR 2.34 - Where can I get a copy of DOI's FOIA annual report?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Where can I get a copy of DOI's FOIA... AND TESTIMONY; FREEDOM OF INFORMATION ACT FOIA Annual Report § 2.34 Where can I get a copy of DOI's FOIA annual report? Under 5 U.S.C. 552(e), DOI is required to prepare an annual report regarding its...

2 CFR 1401.401 - Whom in the DOI does a recipient who is an individual notify about a criminal drug conviction?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Whom in the DOI does a recipient who is an individual notify about a criminal drug conviction? 1401.401 Section 1401.401 Grants and Agreements Federal... Whom in the DOI does a recipient who is an individual notify about a criminal drug conviction? The DOI...

Proceedings of a Coastal and Marine Spatial Planning Workshop for the Western United States

USGS Publications Warehouse

Thorsteinson, Lyman; Hirsch, Derrick; Helweg, David; Dhanju, Amardeep; Barmenski, Joan; Ferrero, Richard

2011-01-01

Recent scientific and ocean policy assessments demonstrate that a fundamental change in our current management system is required to achieve the long-term health of our ocean, coasts, and Great Lakes in order to sustain the services and benefits they provide to society. The present (2011) species- and sector-centric way we manage these ecosystems cannot account properly for cumulative effects, sustaining multiple ecosystem services, and holistically and explicitly evaluating the tradeoffs associated with proposed alternative and multiple human uses. A transition to an ecosystem-based approach to management and conservation of coastal and marine resources is needed. Competing uses and activities such as commerce, recreation, cultural practices, energy development, conservation, and national security are increasing pressure for new and expanded resource usage in coastal marine ecosystems. Current management efforts use a sector-by-sector approach that mostly focuses on a limited range of tools and outcomes [for example, oil and gas leases, fishery management plans, and Marine Protected Areas (MPAs)]. A comprehensive, ecosystem-based, and proactive approach to planning and managing these uses and activities is needed. Further, scientific understanding and information are essential to achieve an integrated decision-making process that includes knowledge of ecosystem services, existing and possible future conditions, and potential consequences of natural and anthropogenic events. Because no single government agency has executive authority for coastal or ocean resources, conflicting objectives around competing uses abound. In recent years, regional- and state-level initiatives in Coastal and Marine Spatial Planning (CMSP) have emerged to coordinate management activities. In some respects, the components and steps of the overall CMSP process are similar to how existing ocean resources are regulated and managed. For example, the Bureau of Ocean Energy Management Regulation and Enforcement (BOEMRE) uses spatial planning exercises in State Renewable Energy Task Force meetings to identify competing and conflicting ocean uses, and to delineate areas suitable for renewable energy development. Similarly terrestrial areas such as in national parks and national wildlife refuges managed by the Department of the Interior (DOI) prepare management plans for preservation and restoration of species and habitats of concern, some of which are protected by law. The analogy to CMSP is clear - multiple users and multiple expectations, resulting in the requirement to establish spatial plans for management of different resources and different ecosystem services. A two-day workshop on December 1-2, 2010, was convened for DOI representatives and several key non-DOI participants with roles in CMSP as a step toward clarifying national perspectives and consequences of the National Ocean Policy for the West (appendix 1). Discussions helped to develop an understanding of CMSP from the federal perspective and to identify regional priorities. An overarching theme was to promote a better understanding of current and future science needs. The workshop format included briefings by key Federal agencies on their understanding of the national focus followed by discussion of regional issues, including the needs for scientific information and coordination. The workshop also explored potential science contributions by Federal agencies and others; utilizing current capabilities, data, and information systems; and provided a foundation for possible future regional workshops focusing in turn on the West Coast Region (California, Oregon, and Washington), Pacific Islands (sometimes referred to as Oceania) and Alaska. Participants were asked to share information in the following areas, recognizing that the purpose would be to learn more about the national perspective (see appendixes 2-4): Explore how the Western U.S. (Alaska, Pacific Islands, and West Coast Region) migh

Developing Data Citations from Digital Object Identifier Metadata

NASA Technical Reports Server (NTRS)

James, Nathan; Wanchoo, Lalit

2015-01-01

NASA's Earth Science Data and Information System (ESDIS) Project has been processing information for the registration of Digital Object Identifiers (DOI) for the last five years of which an automated system has been in operation for the last two years. The ESDIS DOI registration system has registered over 2000 DOIs with over 1000 DOIs held in reserve until all required information has been collected. By working towards the goal of assigning DOIs to the 8000+ data collections under its management, ESDIS has taken the first step towards facilitating the use of data citations with those products. Jeanne Behnke, ESDIS Deputy Project Manager has reviewed and approved the poster.

Center for Hybrid Communications and Networks

DTIC Science & Technology

2016-09-08

Transmission loop experimental setup to study coded modulation and turbo equalization for metro and long-haul networks, 3) Experimental setup for...undertaking fundamental studies of QKD systems that use ( hyper -) entangled photon pairs or weak coherent states (WCS) as the quantum resources...onlinelibrary.wiley.com/doi/10.1002/047134608X.W8291/abstract] The real-time scope and AWG are also used in fiber-optics transmission loop experiment we

Investigation of the Hydantoin Monomer and its Interaction with Water Molecules

NASA Astrophysics Data System (ADS)

Gruet, Sébastien; Perez, Cristobal; Schnell, Melanie

2017-06-01

Hydantoin (Imidazolidine-2,4-dione, C_3H_4N_2O_2) is a five-membered heterocyclic compound of astrobiological interest. This molecule has been detected in carbonaceous chondrites [1], and its formation can rise from the presence of glycolic acid and urea, two prebiotic molecules [2]. The hydrolysis of hydantoin under acidic conditions can also produce glycine [3], an amino acid actively searched for in the interstellar medium. Spectroscopic data of hydantoin is very limited and mostly dedicated to the solid phase. The high resolution study in gas phase is restricted to the work recently published by Ozeki et al. reporting the pure rotational spectra of the ground state and two vibrational states of the molecule in the millimeter-wave region (90-370 GHz)[4]. Using chirped-pulse Fourier-transform microwave (CP-FTMW) spectroscopy, we recorded the jet-cooled rotational spectra of hydantoin with water between 2 to 8 GHz. We observed the ground state of hydantoin monomer and several water complexes with one or two water molecules. All the observed species exhibit a hyperfine structure due to the two nitrogen atoms present in the molecule, which were fully resolved and analyzed. Additional experiments with a ^{18}O enriched water sample were realized to determine the oxygen-atom positions of the water monomers. These experiments yielded accurate structural information on the preferred water binding sites. The observed complexes and the interactions that hold them together, mainly strong directional hydrogen bonds, will be presented and discussed. [1] Shimoyama, A. and Ogasawara, R., Orig. Life Evol. Biosph., 32, 165-179, 2002. DOI:10.1023/A:1016015319112. [2] Menor-Salván, C. and Marín-Yaseli, M.R., Chem. Soc. Rev., 41(16), 5404-5415, 2012. DOI:10.1039/c2cs35060b. [3] De Marcellus P., Bertrand M., Nuevo M., Westall F. and Le Sergeant d'Hendecourt L., Astrobiology. 11(9), 847-854, 2011. DOI:10.1089/ast.2011.0677. [4] Ozeki, H., Miyahara R., Ihara H., Todaka S., Kobayashi K., and Ohishi M., Astron. Astrophys., Forthcoming article (

A Model for Data Citation in Astronomical Research Using Digital Object Identifiers (DOIs)

NASA Astrophysics Data System (ADS)

Novacescu, Jenny; Peek, Joshua E. G.; Weissman, Sarah; Fleming, Scott W.; Levay, Karen; Fraser, Elizabeth

2018-05-01

Standardizing and incentivizing the use of digital object identifiers (DOIs) to aggregate and identify both data analyzed and data generated by a research project will advance the field of astronomy to match best practices in other research fields like geoscience and medicine. An increase in the use of DOIs will prepare the discipline for changing expectations among funding agencies and publishers, who increasingly expect accurate and thorough data citation to accompany scientific outputs. The use of DOIs ensures a robust, sustainable, and interoperable approach to data citation in which due credit is given to the researchers and institutions who produce and maintain the primary data. We describe in this work the advantages of DOIs for data citation and best practices for integrating a DOI service in an astronomical archive. We report on a pilot project carried out in collaboration with AAS journals. During the course of the 1.5-year long pilot, over 75% of submitting authors opted to use the integrated DOI service to clearly identify data analyzed during their research project when prompted at the time of paper submission.

Data always getting bigger -- A scalable DOI architecture for big and expanding scientific data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prakash, Giri; Shrestha, Biva; Younkin, Katarina

The Atmospheric Radiation Measurement (ARM) Data Archive established a data citation strategy based on Digital Object Identifiers (DOIs) for the ARM datasets in order to facilitate citing continuous and diverse ARM datasets in articles and other papers. This strategy eases the tracking of data provided as supplements to articles and papers. Additionally, it allows future data users and the ARM Climate Research Facility to easily locate the exact data used in various articles. Traditionally, DOIs are assigned to individual digital objects (a report or a data table), but for ARM datasets, these DOIs are assigned to an ARM data product.more » This eliminates the need for creating DOIs for numerous components of the ARM data product, in turn making it easier for users to manage and cite the ARM data with fewer DOIs. In addition, the ARM data infrastructure team, with input from scientific users, developed a citation format and an online data citation generation tool for continuous data streams. As a result, this citation format includes DOIs along with additional details such as spatial and temporal information.« less

Data always getting bigger -- A scalable DOI architecture for big and expanding scientific data

DOE PAGES

Prakash, Giri; Shrestha, Biva; Younkin, Katarina; ...

2016-08-31

The Atmospheric Radiation Measurement (ARM) Data Archive established a data citation strategy based on Digital Object Identifiers (DOIs) for the ARM datasets in order to facilitate citing continuous and diverse ARM datasets in articles and other papers. This strategy eases the tracking of data provided as supplements to articles and papers. Additionally, it allows future data users and the ARM Climate Research Facility to easily locate the exact data used in various articles. Traditionally, DOIs are assigned to individual digital objects (a report or a data table), but for ARM datasets, these DOIs are assigned to an ARM data product.more » This eliminates the need for creating DOIs for numerous components of the ARM data product, in turn making it easier for users to manage and cite the ARM data with fewer DOIs. In addition, the ARM data infrastructure team, with input from scientific users, developed a citation format and an online data citation generation tool for continuous data streams. As a result, this citation format includes DOIs along with additional details such as spatial and temporal information.« less

2 CFR 1401.335 - Whom in the DOI does a recipient other than an individual notify about a criminal drug conviction?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Whom in the DOI does a recipient other than... Individuals § 1401.335 Whom in the DOI does a recipient other than an individual notify about a criminal drug conviction? The DOI is not designating a central location for the receipt of these reports. Therefore you...

Research Spotlight: Groundwater is being depleted rapidly in California's Central Valley

NASA Astrophysics Data System (ADS)

Tretkoff, Ernie

2011-03-01

Groundwater is being depleted in California's Central Valley at a rapid rate, according to data from the Gravity Recovery and Climate Experiment (GRACE) satellite. Famiglietti et al. analyzed 78 months of GRACE data covering October 2003 to March 2010 to estimate water storage changes in California's Sacramento and San Joaquin river basins. They found that the basins are losing water at a rate of about 30 millimeters per year equivalent water height, or a total of about 30 cubic kilometers over the 78-month period. Furthermore, they found that two thirds of this loss, or a total of 20 cubic kilometers for the study period, came from groundwater depletion in the Central Valley. Quantifying groundwater depletion can be challenging in many areas because of a lack of monitoring infrastructure and reporting requirements; the study shows that satellite-based monitoring can be a useful way to track groundwater volumes. The authors warn that the current rate of groundwater depletion in the Central Valley may be unsustainable and could have “potentially dire consequences for the economic and food security of the United States.” (Geophysical Research Letters, doi:10.1029/2010GL046442, 2011)

Acculturation and Psychological Adjustment of Vietnamese Refugees: An Ecological Acculturation Framework.

PubMed

Salo, Corrina D; Birman, Dina

2015-12-01

Acculturation to the culture of the host society as well as to one's heritage culture have been shown to impact immigrants' adjustment during the years following resettlement. While acculturation has been identified as an important factor in adjustment of Vietnamese immigrants (Birman and Tran in Am J Orthopsychiatr 78(1):109-120. doi: 10.1037/0002-9432.78.1.109 , 2008), no clear pattern of findings has emerged and too few studies have employed an ecological approach. The purpose of this paper is to contextualize the study of acculturation and adjustment by taking an ecological approach to exploring these relationships across several life domains, using a bilinear scale, and examining mediators of these relationships for adult Vietnamese refugees (N = 203) in the United States. We call this approach the Ecological Acculturation Framework (EAF). Results of a structural equation model (SEM) showed that job satisfaction fully mediated the relationship between American acculturation and psychological distress, demonstrating that this relationship was specific to an occupational domain. However, while Vietnamese acculturation predicted co-ethnic social support satisfaction, it did not predict reduced psychological distress. Implications for a life domains approach, including domain specificity, are discussed.

Report from the Workshop on Coregonine Restoration Science

USGS Publications Warehouse

Bronte, Charles R.; Bunnell, David B.; David, Solomon R.; Gordon, Roger; Gorsky, Dimitry; Millard, Michael J.; Read, Jennifer; Stein, Roy A.; Vaccaro, Lynn

2017-08-03

SummaryGreat Lakes fishery managers have the opportunity and have expressed interest in reestablishing a native forage base in the Great Lakes consisting of various forms and species within the genus Coregonus. This report summarizes the proceedings of a workshop focused on a subset of the genus, and the term “coregonines” is used to refer to several species of deepwater ciscoes (also known as “chubs”) and the one more pelagic-oriented cisco species (Coregonus artedi, also known as “lake herring”). As the principal conservation agency for the United States Government, the Department of Interior has unique and significant authorities and capacities to support a coregonine reestablishment program in the Great Lakes. To identify and discuss key uncertainties associated with such a program and develop a coordinated approach, the U.S. Geological Survey (USGS) and the U.S. Fish and Wildlife Service (FWS), the principal Department of the Interior bureaus to address Great Lakes fishery issues, held the first of a series of workshops on coregonine science in Ann Arbor, Michigan, on October 11–13, 2016. Workshop objectives were to identify (1) perceived key uncertainties associated with coregonine restoration in the Great Lakes and (2) DOI capacities for addressing these key uncertainties.

The Imperial County Community Air Monitoring Network: A Model for Community-based Environmental Monitoring for Public Health Action

PubMed Central

Olmedo, Luis; Bejarano, Ester; Lugo, Humberto; Murillo, Eduardo; Seto, Edmund; Wong, Michelle; King, Galatea; Wilkie, Alexa; Meltzer, Dan; Carvlin, Graeme; Jerrett, Michael; Northcross, Amanda

2017-01-01

Summary: The Imperial County Community Air Monitoring Network (the Network) is a collaborative group of community, academic, nongovernmental, and government partners designed to fill the need for more detailed data on particulate matter in an area that often exceeds air quality standards. The Network employs a community-based environmental monitoring process in which the community and researchers have specific, well-defined roles as part of an equitable partnership that also includes shared decision-making to determine study direction, plan research protocols, and conduct project activities. The Network is currently producing real-time particulate matter data from 40 low-cost sensors throughout Imperial County, one of the largest community-based air networks in the United States. Establishment of a community-led air network involves engaging community members to be citizen-scientists in the monitoring, siting, and data collection process. Attention to technical issues regarding instrument calibration and validation and electronic transfer and storage of data is also essential. Finally, continued community health improvements will be predicated on facilitating community ownership and sustainability of the network after research funds have been expended. https://doi.org/10.1289/EHP1772 PMID:28886604

STS-87 crew and VIPs inspect the orbiter Columbia after landing

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 crew members regard the tiles underneath the orbiter Columbia shortly after its return to Runway 33 at Kennedy Space Center's Shuttle Landing Facility. Pointing to the tiles is the president of the National Space Development Agency (NASDA) of Japan, Isao Uchida, who is standing next to NASA Administrator Daniel Goldin. STS-87 Commander Kevin Kregel, at right, looks on as Pilot Steve Lindsey follows behind him to continue inspecting the orbiter. STS-87 concluded its mission with a main gear touchdown at 7:20:04 a.m. EST Dec. 5, drawing the 15-day, 16-hour and 34-minute-long mission of 6.5 million miles to a close. Also onboard the orbiter were Mission Specialists Winston Scott; Kalpana Chawla, Ph.D.; and Takao Doi, Ph.D., of NASDA; along with Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. During the 88th Space Shuttle mission, the crew performed experiments on the United States Microgravity Payload-4 and pollinated plants as part of the Collaborative Ukrainian Experiment. This was the 12th landing for Columbia at KSC and the 41st KSC landing in the history of the Space Shuttle program.

STS-87 Mission Highlights Resources Tape

NASA Technical Reports Server (NTRS)

1998-01-01

The STS-87 mission the flight crew, Commander Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk present an overview of there mission. STS-87 will fly the United States Microgravity Payload (USMP-4), the Spartan-201, the Orbital Acceleration Research Experiment (OARE), the EVA Demonstration Flight Test 5 (EDFT-05). The objective of the observations are to investigate the mechanisms causing the heating of the solar corona and the acceleration of the solar wind which originates in the corona. While flying separately in the cargo bay, the Orbital Acceleration Research Experiment (OARE) is an integral part of USMP-04. It is a highly sensitive instrument designed to acquire and record data of low-level aerodynamic acceleration along the orbiter's principal axes in the free-molecular flow regime at orbital altitudes and in the transition regime during re-entry. OARE data will support advances in space materials processing by providing measurements of the low-level, low frequency disturbance environment affecting various microgravity experiments. OARE data will also support advances in orbital drag prediction technology by increasing the understanding of the fundamental flow phenomena in the upper atmosphere.

Using Behavioral Risk Factor Data as a surveillance tool to monitor the prevalence of initiation, continuation and completion of Human Papilloma Virus vaccination in children.

PubMed

Barboza, Gia Elise; Dominguez, Silvia

2016-06-01

The Human Papilloma Virus ("HPV") is a common sexually transmitted disease that has infected approximately 79 million men and women in the United States alone. A vaccination is available but in order to be effective it must be received prior to becoming sexually active and recipients must complete a three-dose sequence. In this article we explore the predisposing, enabling and need-based factors associated with parents' or guardians' decision to have their child initiate, continue and complete the Human Papilloma Virus (HPV) vaccine. The data file includes 5531 parents and guardians with presumptive knowledge regarding the number of HPV vaccination their child received. Data includes information on the child (e.g. child׳s age) as well as the adult respondent (e.g. health insurance status). A smaller subset of the dataset along with the code to run the model are supplied with this article. The interpretation of these data can be found in the research article published by the authors in the Journal of Preventive Medicine in 2015 http://dx.doi.org/10.1016/j.ypmed.2016.01.010[1].

A Field-Scale Sensor Network Data Set for Monitoring and Modeling the Spatial and Temporal Variation of Soil Water Content in a Dryland Agricultural Field

NASA Astrophysics Data System (ADS)

Gasch, C. K.; Brown, D. J.; Campbell, C. S.; Cobos, D. R.; Brooks, E. S.; Chahal, M.; Poggio, M.

2017-12-01

We describe a soil water content monitoring data set and auxiliary data collected at a 37 ha experimental no-till farm in the Northwestern United States. Water content measurements have been compiled hourly since 2007 by ECH2O-TE and 5TE sensors installed at 42 locations and five depths (0.3, 0.6, 0.9, 1.2, and 1.5 m, 210 sensors total) across the R.J. Cook Agronomy Farm, a Long-Term Agro-Ecosystem Research Site stationed on complex terrain in a Mediterranean climate. In addition to soil water content readings, the data set includes hourly and daily soil temperature readings, annual crop histories, a digital elevation model, Bt horizon maps, seasonal apparent electrical conductivity, soil texture, and soil bulk density. Meteorological records are also available for this location. We discuss the unique challenges of maintaining the network on an operating farm and demonstrate the nature and complexity of the soil water content data. This data set is accessible online through the National Agriculture Library, has been assigned a DOI, and will be maintained for the long term.

Navajo Generating Station and Federal Resource Planning; Volume 1: Sectoral, Technical, and Economic Trends

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurlbut, David; Haase, Scott; Barrows, Clayton

This study for the U.S. Bureau of Reclamation examines conditions in the electricity sector that are likely to affect federal decisions with respect to Navajo Generating Station (NGS), the largest coal-fired power plant operating in the western United States. The federal government owns 24.3% of the 2.25-gigawatt plant, which amounts to 547 megawatts (MW) of capacity. By focusing on the unique public interests that depend on the federal share of NGS, this baseline study can help the federal government develop a road map for meeting all of its goals with respect to water delivery, clean energy, emission reduction, and economicmore » development. There is no recommendation for action in this report. Rather, its aim is to provide a credible, thorough description of baseline conditions that might affect federal decisions regarding NGS. It describes facts and trends embedded in current data, but there are no conclusions about how Reclamation or DOI should respond to the trends. The interdependencies among the many sectoral trends and federal goals are complex, and the aim of this study is to provide a foundation from which options can be tested in a deliberate manner.« less

A multidisciplinary analysis of groundwater declines and agricultural production in the High Plains Aquifer of Kansas

NASA Astrophysics Data System (ADS)

Steward, David R.; Bruss, Paul J.; Yang, Xiaoying; Staggenborg, Scott A.; Welch, Stephen M.; Apley, Michael D.

2014-05-01

The High Plains Aquifer provides groundwater for 30% of the irrigated agriculture in the USA. Within Kansas, groundwater supports the congressional district with highest market value of agriculture. And yet, over-pumping and associated groundwater declines threaten the long-term prospects. The groundwater portion of this study quantifies the availability of groundwater stores over the next 100 years. A water-use function is developed to quantify the historical and future impacts of irrigation on corn production. A relationship between corn consumption per head of cattle quantifies the herd size that can be supported by irrigated corn. Together, we project the impacts of changes in groundwater stores on corn and cattle production for the next century. Scenarios analyze the impacts of water savings today on current and future agriculture production. Reference: Steward, D. R., Bruss, P. J., Yang, X., Staggenborg, S. A., Welch, S. M. and M. D. Apley, Tapping unsustainable groundwater stores for agricultural production in the High Plains Aquifer of Kansas, projections to 2110, Proceedings of the National Academy of Sciences of the United States of America, 110(37) E3477-E3486, September 10, 2013. http://dx.doi.org/10.1073/pnas.1220351110

Ecological landscape elements: long-term monitoring in Great Britain, the Countryside Survey 1978-2007 and beyond

NASA Astrophysics Data System (ADS)

Wood, Claire M.; Bunce, Robert G. H.; Norton, Lisa R.; Maskell, Lindsay C.; Smart, Simon M.; Scott, W. Andrew; Henrys, Peter A.; Howard, David C.; Wright, Simon M.; Brown, Michael J.; Scott, Rod J.; Stuart, Rick C.; Watkins, John W.

2018-04-01

The Countryside Survey (CS) of Great Britain (GB) provides a unique and statistically robust series of datasets, consisting of an extensive set of repeated ecological measurements at a national scale, covering a time span of 29 years. CS was first undertaken in 1978 to provide a baseline for ecological and land use change monitoring in the rural environment of GB, following a stratified random design, based on 1 km squares. Originally, eight random 1 km squares were drawn from each of 32 environmental classes, thus comprising 256 sample squares in the 1978 survey. The number of these sites increased to 382 in 1984, 506 in 1990, 569 in 1998 and 591 in 2007. Detailed information regarding vegetation types and land use was mapped in all five surveys, allowing reporting by defined standard habitat classifications. Additionally, point and linear landscape features (such as trees and hedgerows) are available from all surveys after 1978. From these stratified, randomly located sample squares, information can be converted into national estimates, with associated error terms. Other data, relating to soils, freshwater and vegetation, were also sampled on analogous dates. However, the present paper describes only the surveys of landscape features and habitats. The resulting datasets provide a unique, comprehensive, quantitative ecological coverage of extent and change in these features in GB. Basic results are presented and their implications discussed. However, much opportunity for further analyses remains. Data from each of the survey years are available via the following DOIs: Landscape area data 1978: https://doi.org/10.5285/86c017ba-dc62-46f0-ad13-c862bf31740e, 1984: https://doi.org/10.5285/b656bb43-448d-4b2c-aade-7993aa243ea3, 1990: https://doi.org/10.5285/94f664e5-10f2-4655-bfe6-44d745f5dca7, 1998: https://doi.org/10.5285/1e050028-5c55-42f4-a0ea-c895d827b824, and 2007: https://doi.org/10.5285/bf189c57-61eb-4339-a7b3-d2e81fdde28d; Landscape linear feature data 1984: https://doi.org/10.5285/a3f5665c-94b2-4c46-909e-a98be97857e5, 1990: https://doi.org/10.5285/311daad4-bc8c-485a-bc8a-e0d054889219, 1998: https://doi.org/10.5285/8aaf6f8c-c245-46bb-8a2a-f0db012b2643 and 2007: https://doi.org/10.5285/e1d31245-4c0a-4dee-b36c-b23f1a697f88, Landscape point feature data 1984: https://doi.org/10.5285/124b872e-036e-4dd3-8316-476b5f42c16e, 1990: https://doi.org/10.5285/1481bc63-80d7-4d18-bcba-8804aa0a9e1b, 1998: https://doi.org/10.5285/ed10944f-40c8-4913-b3f5-13c8e844e153 and 2007: https://doi.org/10.5285/55dc5fd7-d3f7-4440-b8a7-7187f8b0550b.

7 CFR 1160.104 - United States.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 9 2012-01-01 2012-01-01 false United States. 1160.104 Section 1160.104 Agriculture... Definitions § 1160.104 United States. United States means the 48 contiguous states in the continental United States and the District of Columbia, except that United States means the 50 states of the United States...

7 CFR 1160.104 - United States.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 9 2011-01-01 2011-01-01 false United States. 1160.104 Section 1160.104 Agriculture... Definitions § 1160.104 United States. United States means the 48 contiguous states in the continental United States and the District of Columbia, except that United States means the 50 states of the United States...

7 CFR 1160.104 - United States.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 9 2014-01-01 2013-01-01 true United States. 1160.104 Section 1160.104 Agriculture... Definitions § 1160.104 United States. United States means the 48 contiguous states in the continental United States and the District of Columbia, except that United States means the 50 states of the United States...

7 CFR 1160.104 - United States.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 9 2013-01-01 2013-01-01 false United States. 1160.104 Section 1160.104 Agriculture... Definitions § 1160.104 United States. United States means the 48 contiguous states in the continental United States and the District of Columbia, except that United States means the 50 states of the United States...

7 CFR 1160.104 - United States.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true United States. 1160.104 Section 1160.104 Agriculture... Definitions § 1160.104 United States. United States means the 48 contiguous states in the continental United States and the District of Columbia, except that United States means the 50 states of the United States...

Quantifying Slope Effects and Variations in Crater Density across a Single Geologic Unit

NASA Astrophysics Data System (ADS)

Meyer, Heather; Mahanti, Prasun; Robinson, Mark; Povilaitis, Reinhold

2016-10-01

Steep underlying slopes (>~5°) significantly increase the rate of degradation of craters [1-3]. As a result, the density of craters is less on steeper slopes for terrains of the same age [2, 4]. Thus, when age-dating a planetary surface, an area encompassing one geologic unit of constant low slope is chosen. However, many key geologic units, such as ejecta blankets, lack sufficient area of constant slope to derive robust age estimates. Therefore, accurate age-dating of such units requires an accurate understanding of the effects of slope on age estimates. This work seeks to determine if the observed trend of decreasing crater density with increasing slopes [2] holds for craters >1 km and to quantify the effect of slope for craters of this size, focusing on the effect of slopes over the kilometer scale. Our study focuses on the continuous ejecta of Orientale basin, where we measure craters >1 km excluding secondaries that occur as chains or clusters. Age-dating via crater density measurements relies on uniform cratering across a single geologic unit. In the case of ejecta blankets and other impact related surfaces, this assumption may not hold due to the formation of auto- secondary craters. As such, we use LRO WAC mosaics [5], crater size-frequency distributions, absolute age estimates, a 3 km slope map derived from the WAC GLD100 [6], and density maps for various crater size ranges to look for evidence of non-uniform cratering across the continuous ejecta of Orientale and to determine the effect of slope on crater density. Preliminary results suggest that crater density does decrease with increasing slope for craters >1 km in diameter though at a slower rate than for smaller craters.References: [1] Trask N. J. and Rowan L. C. (1967) Science 158, 1529-1535. [2] Basilevsky (1976) Proc. Lunar Sci. Conf. 7th, p. 1005-1020. [3] Pohn and Offield (1970) USGS Prof. Pap., 153-162. [4] Xiao et al. (2013) Earth and Planet. Sci. Lett., 376, pgs. 1-11. doi:10.1016/j.epsl.2013.06.015. [5] Robinson M. S. et al. (2010) Space Sci. Rev. 150, 81 -124. [6] Scholten F. et al. (2011), JGR, 117, doi:10.1029/2011JE003926

43 CFR 2.34 - Where can I get a copy of DOI's FOIA annual report?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Where can I get a copy of DOI's FOIA annual report? 2.34 Section 2.34 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT FOIA Annual Report § 2.34 Where can I get a copy of DOI's FOIA annual report? Under 5 U.S.C. 552(e), DOI is...

Evolving a NASA Digital Object Identifiers System with Community Engagement

NASA Astrophysics Data System (ADS)

Wanchoo, L.; James, N.

2016-12-01

In 2010, NASA's Earth Science Data and Information System (ESDIS) Project began investigating the assignment of unique identifiers to its suite of data products being stewarded at data centers distributed across the country. This process led to the use of Digital Object Identifiers (DOIs) and the development of an automated system for the registration of these DOIs. Since that time, the ESDIS DOI registration system has evolved to be fully functional with over 3000 publicly accessible DOIs and over 1000 being held in reserve status until the information required for registration is obtained. The goal is to assign DOIs to the entire 7000+ data collections under ESDIS management via its network of discipline-oriented data centers. A key factor in the successful evolution of the DOI registration system has been the incorporation of community input. Over the last 3 years, ESDIS has solicited community input for making the DOI registration process more efficient through three focus groups under NASA's Earth Science Data System Working Group (ESDSWG). These groups were largely composed of DOI submitters and data curators from the 12 data centers serving user communities of various science disciplines. The suggestions from these groups were formulated into recommendations for ESDIS consideration and implementation. This poster will describe the process and the activities of each focus group, their recommendations, and how these recommendations were implemented.

31 CFR 515.321 - United States; continental United States.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false United States; continental United... General Definitions § 515.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including the Trust Territory of...

31 CFR 535.321 - United States; continental United States.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false United States; continental United... General Definitions § 535.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof including the Trust Territory of...

31 CFR 535.321 - United States; continental United States.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false United States; continental United... General Definitions § 535.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof including the Trust Territory of...

31 CFR 535.321 - United States; continental United States.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States; continental United... General Definitions § 535.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof including the Trust Territory of...

31 CFR 515.321 - United States; continental United States.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States; continental United... General Definitions § 515.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including the Trust Territory of...

31 CFR 515.321 - United States; continental United States.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false United States; continental United... General Definitions § 515.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including the Trust Territory of...

31 CFR 500.321 - United States; continental United States.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States; continental United... General Definitions § 500.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including U.S. trust territories...

31 CFR 515.321 - United States; continental United States.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false United States; continental United... General Definitions § 515.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including the Trust Territory of...

31 CFR 535.321 - United States; continental United States.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false United States; continental United... General Definitions § 535.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof including the Trust Territory of...

31 CFR 535.321 - United States; continental United States.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false United States; continental United... General Definitions § 535.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof including the Trust Territory of...

31 CFR 515.321 - United States; continental United States.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false United States; continental United... General Definitions § 515.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including the Trust Territory of...

A novel method to calibrate DOI function of a PET detector with a dual-ended-scintillator readout.

PubMed

Shao, Yiping; Yao, Rutao; Ma, Tianyu

2008-12-01

The detection of depth-of-interaction (DOI) is a critical detector capability to improve the PET spatial resolution uniformity across the field-of-view and will significantly enhance, in particular, small bore system performance for brain, breast, and small animal imaging. One promising technique of DOI detection is to use dual-ended-scintillator readout that uses two photon sensors to detect scintillation light from both ends of a scintillator array and estimate DOI based on the ratio of signals (similar to Anger logic). This approach needs a careful DOI function calibration to establish accurate relationship between DOI and signal ratios, and to recalibrate if the detection condition is shifted due to the drift of sensor gain, bias variations, or degraded optical coupling, etc. However, the current calibration method that uses coincident events to locate interaction positions inside a single scintillator crystal has severe drawbacks, such as complicated setup, long and repetitive measurements, and being prone to errors from various possible misalignments among the source and detector components. This method is also not practically suitable to calibrate multiple DOI functions of a crystal array. To solve these problems, a new method has been developed that requires only a uniform flood source to irradiate a crystal array without the need to locate the interaction positions, and calculates DOI functions based solely on the uniform probability distribution of interactions over DOI positions without knowledge or assumption of detector responses. Simulation and experiment have been studied to validate the new method, and the results show that the new method, with a simple setup and one single measurement, can provide consistent and accurate DOI functions for the entire array of multiple scintillator crystals. This will enable an accurate, simple, and practical DOI function calibration for the PET detectors based on the design of dual-ended-scintillator readout. In addition, the new method can be generally applied to calibrating other types of detectors that use the similar dual-ended readout to acquire the radiation interaction position.

A novel method to calibrate DOI function of a PET detector with a dual-ended-scintillator readout

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shao Yiping; Yao Rutao; Ma Tianyu

The detection of depth-of-interaction (DOI) is a critical detector capability to improve the PET spatial resolution uniformity across the field-of-view and will significantly enhance, in particular, small bore system performance for brain, breast, and small animal imaging. One promising technique of DOI detection is to use dual-ended-scintillator readout that uses two photon sensors to detect scintillation light from both ends of a scintillator array and estimate DOI based on the ratio of signals (similar to Anger logic). This approach needs a careful DOI function calibration to establish accurate relationship between DOI and signal ratios, and to recalibrate if the detectionmore » condition is shifted due to the drift of sensor gain, bias variations, or degraded optical coupling, etc. However, the current calibration method that uses coincident events to locate interaction positions inside a single scintillator crystal has severe drawbacks, such as complicated setup, long and repetitive measurements, and being prone to errors from various possible misalignments among the source and detector components. This method is also not practically suitable to calibrate multiple DOI functions of a crystal array. To solve these problems, a new method has been developed that requires only a uniform flood source to irradiate a crystal array without the need to locate the interaction positions, and calculates DOI functions based solely on the uniform probability distribution of interactions over DOI positions without knowledge or assumption of detector responses. Simulation and experiment have been studied to validate the new method, and the results show that the new method, with a simple setup and one single measurement, can provide consistent and accurate DOI functions for the entire array of multiple scintillator crystals. This will enable an accurate, simple, and practical DOI function calibration for the PET detectors based on the design of dual-ended-scintillator readout. In addition, the new method can be generally applied to calibrating other types of detectors that use the similar dual-ended readout to acquire the radiation interaction position.« less

Digital Object Identifiers for NASA's Earth Observing System Products

NASA Astrophysics Data System (ADS)

Moses, J. F.; James, N.

2012-12-01

The science community has long recognized the importance of citing data in published literature to encourage replication of experiments and verification of results. Authors that try to cite their data often find that publishers will not accept Internet addresses because they are viewed as transient references, frequently changed by the data provider after the paper is published. Digital Object Identifiers (DOIs) and the DOI® System were created to avoid this problem by providing a unique and persistent identifier scheme and an online resolution service. DOIs and the Internet service provided by the DOI System have emerged as the most acceptable scheme for publishers. NASA's Earth Science Data and Information System (ESDIS) Project, in cooperation with several Earth Observing System (EOS) instrument teams and data providers, has developed methods for assigning DOIs to EOS products. By assigning DOIs we are enabling authors and publishers to find it easier and more compelling to cite EOS data products. DOIs are unique alphanumeric strings that consist of a prefix and suffix. The prefix is assigned by a registration agency for the DOI System. The suffix must be unique, but is otherwise free to be constructed by the publisher, in this case NASA ESDIS Project. A strategy was needed for constructing DOI suffix names that corresponds to each EOS product. Since the onset of the DOI System, publishers have developed conventions to suit their own purposes. These range from random generation to complex, formally controlled vocabularies. An overarching ESDIS goal has been for the DOI names to be attractive for researchers to use in publication applications. Keeping them short and simple is paramount. When adding meaning to the string, it is also important that the name only refer to the data and not to the publisher, so that the DOI can be accepted as persistent even if the data is moved to a new publisher. Most users download EOS product files to their local facilities when they want to use the data for analysis or applications. By imbedding DOIs in the file metadata, users have access to the DOI value long after the product has left the source data center. This enables users to find documentation about the product in the future - long after it has left the contextual environment of the data provider. Existing HDF and netCDF metadata structures have been adapted to accommodate the addition of DOIs. In addition, associated EOSDIS core metadata will also contain a product specific attribute for DOIs. Advances in computer science and Internet brought about a host of data identification schemes designed to solve problems inherent in developing advanced provenance models. Lessons from trying to use early satellite observations in climate studies today point to the importance of providing links in data archives to documentation and publications about the data. Data system engineers link data records to standard product documentation prepared at the time of the mission and archive with the data, but will need to add links to the whole range of information needed to support future research and long-term climate studies. DOIs can serve this need if referenced by developers when preparing technical data and reports, as well as when publishing research results.

Determining the Depth of Injury in Bioengineered Tissue Models of Cornea and Conjunctiva for the Prediction of All Three Ocular GHS Categories

PubMed Central

Zorn-Kruppa, Michaela; Houdek, Pia; Wladykowski, Ewa; Engelke, Maria; Bartok, Melinda; Mewes, Karsten R.; Moll, Ingrid; Brandner, Johanna M.

2014-01-01

The depth of injury (DOI) is a mechanistic correlate to the ocular irritation response. Attempts to quantitatively determine the DOI in alternative tests have been limited to ex vivo animal eyes by fluorescent staining for biomarkers of cell death and viability in histological cross sections. It was the purpose of this study to assess whether DOI could also be measured by means of cell viability detected by the MTT assay using 3-dimensional (3D) reconstructed models of cornea and conjunctiva. The formazan-free area of metabolically inactive cells in the tissue after topical substance application is used as the visible correlate of the DOI. Areas of metabolically active or inactive cells are quantitatively analyzed on cryosection images with ImageJ software analysis tools. By incorporating the total tissue thickness, the relative MTT-DOI (rMTT-DOI) was calculated. Using the rMTT-DOI and human reconstructed cornea equivalents, we developed a prediction model based on suitable viability cut-off values. We tested 25 chemicals that cover the whole range of eye irritation potential based on the globally harmonized system of classification and labelling of chemicals (GHS). Principally, the MTT-DOI test method allows distinguishing between the cytotoxic effects of the different chemicals in accordance with all 3 GHS categories for eye irritation. Although the prediction model is slightly over-predictive with respect to non-irritants, it promises to be highly valuable to discriminate between severe irritants (Cat. 1), and mild to moderate irritants (Cat. 2). We also tested 3D conjunctiva models with the aim to specifically address conjunctiva-damaging substances. Using the MTT-DOI method in this model delivers comparable results as the cornea model, but does not add additional information. However, the MTT-DOI method using reconstructed cornea models already provided good predictability that was superior to the already existing established in vitro/ex vivo methods. PMID:25494045

Structural characterization of ribosome recruitment and translocation by type IV IRES

PubMed Central

Murray, Jason; Savva, Christos G; Shin, Byung-Sik; Dever, Thomas E; Ramakrishnan, V; Fernández, Israel S

2016-01-01

Viral mRNA sequences with a type IV IRES are able to initiate translation without any host initiation factors. Initial recruitment of the small ribosomal subunit as well as two translocation steps before the first peptidyl transfer are essential for the initiation of translation by these mRNAs. Using electron cryomicroscopy (cryo-EM) we have structurally characterized at high resolution how the Cricket Paralysis Virus Internal Ribosomal Entry Site (CrPV-IRES) binds the small ribosomal subunit (40S) and the translocation intermediate stabilized by elongation factor 2 (eEF2). The CrPV-IRES restricts the otherwise flexible 40S head to a conformation compatible with binding the large ribosomal subunit (60S). Once the 60S is recruited, the binary CrPV-IRES/80S complex oscillates between canonical and rotated states (Fernández et al., 2014; Koh et al., 2014), as seen for pre-translocation complexes with tRNAs. Elongation factor eEF2 with a GTP analog stabilizes the ribosome-IRES complex in a rotated state with an extra ~3 degrees of rotation. Key residues in domain IV of eEF2 interact with pseudoknot I (PKI) of the CrPV-IRES stabilizing it in a conformation reminiscent of a hybrid tRNA state. The structure explains how diphthamide, a eukaryotic and archaeal specific post-translational modification of a histidine residue of eEF2, is involved in translocation. DOI: http://dx.doi.org/10.7554/eLife.13567.001 PMID:27159451

A Data Model and Task Space for Data of Interest (DOI) Eye-Tracking Analyses.

PubMed

Jianu, Radu; Alam, Sayeed Safayet

2018-03-01

Eye-tracking data is traditionally analyzed by looking at where on a visual stimulus subjects fixate, or, to facilitate more advanced analyses, by using area-of-interests (AOI) defined onto visual stimuli. Recently, there is increasing interest in methods that capture what users are looking at rather than where they are looking. By instrumenting visualization code that transforms a data model into visual content, gaze coordinates reported by an eye-tracker can be mapped directly to granular data shown on the screen, producing temporal sequences of data objects that subjects viewed in an experiment. Such data collection, which is called gaze to object mapping (GTOM) or data-of-interest analysis (DOI), can be done reliably with limited overhead and can facilitate research workflows not previously possible. Our paper contributes to establishing a foundation of DOI analyses by defining a DOI data model and highlighting its differences to AOI data in structure and scale; by defining and exemplifying a space of DOI enabled tasks; by describing three concrete examples of DOI experimentation in three different domains; and by discussing immediate research challenges in creating a framework of visual support for DOI experimentation and analysis.

Selenium, fluorine, and arsenic in surficial materials of the conterminous United States

USGS Publications Warehouse

Shacklette, Hansford T.; Boerngen, Josephine G.; Keith, John R.

1974-01-01

Concentrations of selenium, fluorine, and arsenic in 912, 911, and 910 samples, respectively, of soils and other regoliths from sites approximately 50 miles (80 km) apart throughout the United States are represented on maps by symbols showing five ranges of values. Histograms of the concentrations of these elements are also given. The geometric-mean concentrations (ppm) in the samples, grouped by area, are as follows: Selenium-- Entire United States, 0.31; Western United States, 0.25; and Eastern United States, 0.39. Fluorine-- Entire United States, 180; Western United States, 250; and Eastern United States, 115. Arsenic-- Entire United States, 5.8; Western United States, 6.1; and Eastern United States, 5.4.

Toward Computational Design of High-Efficiency Photovoltaics from First-Principles

DTIC Science & Technology

2016-08-15

dependence of exciton diffusion in conjugated small molecules, Applied Physics Letters, (04 2014): 0. doi: 10.1063/1.4871303 Guangfen Wu, Zi Li, Xu...principle approach based on the time- dependent density functional theory (TDDFT) to describe exciton states, including energy levels and many-body wave... depends more sensitively on the dimension and crystallinity of the acceptor parallel to the interface than normal to the interface. Reorganization

Imaging Prostate Cancer Microenvironment by Collagen Hybridization

DTIC Science & Technology

2013-10-01

There is an emerging concept of using non-cellular solid state compartment as a source for therapeutic targets and for selective imaging of micro ... using second harmonic generation and two-photon micros - copy. J. Biomed. Opt. 14, 044013. Bioconjugate Chemistry Communication dx.doi.org/10.1021...Chiu WC, Lai CC, Liou GG, Li HC, Chou MY: Production of multivalent protein binders using a self- trimerizing collagen-like peptide scaffold. FASEB J

Monolithic Micromachined Quartz Resonator based Infrared Focal Plane Arrays

DTIC Science & Technology

2012-05-05

following categories: PaperReceived Ping Kao, Srinivas Tadigadapa. Micromachined quartz resonator based infrared detector array, Sensors and...0. doi: 10.1088/0957-0233/20/12/124007 2012/05/08 19:47:37 6 S Tadigadapa, K Mateti. Piezoelectric MEMS sensors : state-of-the-art and perspectives...Ping Kao, David L. Allara, Srinivas Tadigadapa. Study of Adsorption of Globular Proteins on Hydrophobic Surfaces, IEEE Sensors Journal, (11 2011): 0

Robust Multi Sensor Classification via Jointly Sparse Representation

DTIC Science & Technology

2016-03-14

rank, sensor network, dictionary learning REPORT DOCUMENTATION PAGE 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 10. SPONSOR/MONITOR’S ACRONYM(S) ARO 8...with ultrafast laser pulses, Optics Express, (04 2015): 10521. doi: Xiaoxia Sun, Nasser M. Nasrabadi, Trac D. Tran. Task-Driven Dictionary Learning...in dictionary design, compressed sensors design, and optimization in sparse recovery also helps. We are able to advance the state of the art

Assessment of the U. S. outer continental shelf environmental studies program. 1. Physical oceanography. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Federal responsibility for oil and gas development on the U.S. outer continental shelf (OCS) resides with the Minerals Management Service (MMS) of the U.S. Department of the Interior (DOI). The DOI's Environmental Studies Program (ESP) is the program through which MMS conducts environmental studies on the OCS and collects information to prepare environmental impact statements (EISs). It appeared to MMS in 1986 that the time was ripe to assess the status of the present program and to explore the needs for future studies. MMS requested an evaluation of the adequacy and applicability of ESP studies, a review of the generalmore » state of knowledge in the appropriate disciplines, and recommendations for future studies. Three panels were established, one of which, the Physical Oceanography Panel, investigated the physical oceanographic aspects of the ESP, the subject of the report, which is the first of three in a series. In reviewing the ESP's physical oceanography program, the panel evaluated the quality and relevance of studies carried out in waters under federal control, which extend from the limits of state jurisdictions (3-12 miles offshore) and include the central and outer continental shelf waters and the continental slope.« less

On the relation between Vicsek and Kuramoto models of spontaneous synchronization

NASA Astrophysics Data System (ADS)

Chepizhko, A. A.; Kulinskii, V. L.

2010-12-01

The Vicsek model for self-propelling particles in 2D is investigated with respect to the addition of the stochastic perturbation of dynamic equations. We show that this model represents in essence the same type of bifurcations under a different type of noise as the celebrated Kuramoto model of spontaneous synchronization. These models demonstrate similar behavior at least within the mean-field approach. To prove this we consider two types of noise for the Vicsek model which are commonly considered in the literature: the intrinsic and the extrinsic ones (according to the terminology of Pimentel et al. [J.A. Pimentel, M. Aldana, C. Huepe, H. Larralde, Intrinsic and extrinsic noise effects on phase transitions of network models with applications to swarming systems, Physical Review E: Statistical, Nonlinear, and Soft Matter Physics 77 (6) (2008) doi:10.1103/PhysRevE.77.061138. URL: http://dx.doi.org/10.1103/PhysRevE.77.061138]). The qualitative correspondence with the bifurcation of stationary states in the Kuramoto model is stated. A new type of stochastic perturbation-the “mixed” noise is proposed. It is constructed as the weighted superposition of the intrinsic and the extrinsic noises. The corresponding phase diagram “noise amplitude vs. interaction strength” is obtained. The possibility of the tricritical behavior for the Vicsek model is predicted.

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

PubMed Central

Li, Meng Amy; Amaral, Paulo P; Cheung, Priscilla; Bergmann, Jan H; Kinoshita, Masaki; Kalkan, Tüzer; Ralser, Meryem; Robson, Sam; von Meyenn, Ferdinand; Paramor, Maike; Yang, Fengtang; Chen, Caifu; Nichols, Jennifer; Spector, David L; Kouzarides, Tony; He, Lin; Smith, Austin

2017-01-01

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute to this regulatory orchestra. We identified a rodent-specific long non-coding RNA (lncRNA) linc1281, hereafter Ephemeron (Eprn), that modulates the dynamics of exit from naïve pluripotency. Eprn deletion delays the extinction of ESC identity, an effect associated with perduring Nanog expression. In the absence of Eprn, Lin28a expression is reduced which results in persistence of let-7 microRNAs, and the up-regulation of de novo methyltransferases Dnmt3a/b is delayed. Dnmt3a/b deletion retards ES cell transition, correlating with delayed Nanog promoter methylation and phenocopying loss of Eprn or Lin28a. The connection from lncRNA to miRNA and DNA methylation facilitates the acute extinction of naïve pluripotency, a pre-requisite for rapid progression from preimplantation epiblast to gastrulation in rodents. Eprn illustrates how lncRNAs may introduce species-specific network modulations. DOI: http://dx.doi.org/10.7554/eLife.23468.001 PMID:28820723

A Population-based Case–Control Study of Urinary Arsenic Species and Squamous Cell Carcinoma in New Hampshire, USA

PubMed Central

Li, Zhigang; Perry, Ann E.; Spencer, Steven K.; Gandolfi, A. Jay; Karagas, Margaret R.

2013-01-01

Background: Chronic high arsenic exposure is associated with squamous cell carcinoma (SCC) of the skin, and inorganic arsenic (iAs) metabolites may play an important role in this association. However, little is known about the carcinogenicity of arsenic at levels commonly observed in the United States. Objective: We estimated associations between total urinary arsenic and arsenic species and SCC in a U.S. population. Methods: We conducted a population-based case–control SCC study (470 cases, 447 controls) in a U.S. region with moderate arsenic exposure through private well water and diet. We measured urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), and summed these arsenic species (ΣAs). Because seafood contains arsenolipids and arsenosugars that metabolize into DMA through alternate pathways, participants who reported seafood consumption within 2 days before urine collection were excluded from the analyses. Results: In adjusted logistic regression analyses (323 cases, 319 controls), the SCC odds ratio (OR) was 1.37 for each ln-transformed microgram per liter increase in ln-transformed ΣAs concentration [ln(ΣAs)] (95% CI: 1.04, 1.80). Urinary ln(MMA) and ln(DMA) also were positively associated with SCC (OR = 1.34; 95% CI: 1.04, 1.71 and OR = 1.34; 95% CI: 1.03, 1.74, respectively). A similar trend was observed for ln(iAs) (OR = 1.20; 95% CI: 0.97, 1.49). Percent iAs, MMA, and DMA were not associated with SCC. Conclusions: These results suggest that arsenic exposure at levels common in the United States relates to SCC and that arsenic metabolism ability does not modify the association. Citation: Gilbert-Diamond D, Li Z, Perry AE, Spencer SK, Gandolfi AJ, Karagas MR. 2013. A population-based case–control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA. Environ Health Perspect 121:1154–1160; http://dx.doi.org/10.1289/ehp.1206178 PMID:23872349

Depth-of-interaction estimates in pixelated scintillator sensors using Monte Carlo techniques

NASA Astrophysics Data System (ADS)

Sharma, Diksha; Sze, Christina; Bhandari, Harish; Nagarkar, Vivek; Badano, Aldo

2017-01-01

Image quality in thick scintillator detectors can be improved by minimizing parallax errors through depth-of-interaction (DOI) estimation. A novel sensor for low-energy single photon imaging having a thick, transparent, crystalline pixelated micro-columnar CsI:Tl scintillator structure has been described, with possible future application in small-animal single photon emission computed tomography (SPECT) imaging when using thicker structures under development. In order to understand the fundamental limits of this new structure, we introduce cartesianDETECT2, an open-source optical transport package that uses Monte Carlo methods to obtain estimates of DOI for improving spatial resolution of nuclear imaging applications. Optical photon paths are calculated as a function of varying simulation parameters such as columnar surface roughness, bulk, and top-surface absorption. We use scanning electron microscope images to estimate appropriate surface roughness coefficients. Simulation results are analyzed to model and establish patterns between DOI and photon scattering. The effect of varying starting locations of optical photons on the spatial response is studied. Bulk and top-surface absorption fractions were varied to investigate their effect on spatial response as a function of DOI. We investigated the accuracy of our DOI estimation model for a particular screen with various training and testing sets, and for all cases the percent error between the estimated and actual DOI over the majority of the detector thickness was ±5% with a maximum error of up to ±10% at deeper DOIs. In addition, we found that cartesianDETECT2 is computationally five times more efficient than MANTIS. Findings indicate that DOI estimates can be extracted from a double-Gaussian model of the detector response. We observed that our model predicts DOI in pixelated scintillator detectors reasonably well.

Settlement with the Department of the Interior (DOI) to Resolve Violations at Schools in Indian Country

EPA Pesticide Factsheets

Consent Agreement with the DOI, BIA and Bureau of Indian Education (BIE) on alleged violations at schools and public water systems owned, operated or the responsibility of DOI. Violations occurred under the CAA, CWA, SDWA, TSCA, ADHERA.

43 CFR 17.323 - Information collection requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of Doi Recipients § 17.323 Information collection requirements. Each recipient shall: (a) Keep records in a form and containing information which DOI determines may be necessary to ascertain whether the recipient is complying with the Act and these regulations. (b) Provide to DOI, upon request...

43 CFR 17.337 - Remedial action by recipients.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Investigation, Conciliation, and Enforcement Procedures § 17.337 Remedial action by recipients. Where DOI finds... DOI may require to overcome the effects of the discrimination. If another recipient exercises control over the recipient that has discriminated, DOI may require both recipients to take remedial action. ...

43 CFR 17.333 - Investigation.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Conciliation, and Enforcement Procedures § 17.333 Investigation. (a) Informal investigation. (1) DOI will... mediation agreement. (2) As part of the initial investigation, DOI will use informal fact finding methods... possible, settle the complaint on terms that are mutually agreeable to the parties. DOI may seek the...

43 CFR 17.333 - Investigation.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., Conciliation, and Enforcement Procedures § 17.333 Investigation. (a) Informal investigation. (1) DOI will... mediation agreement. (2) As part of the initial investigation, DOI will use informal fact finding methods... possible, settle the complaint on terms that are mutually agreeable to the parties. DOI may seek the...

43 CFR 17.323 - Information collection requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... of Doi Recipients § 17.323 Information collection requirements. Each recipient shall: (a) Keep records in a form and containing information which DOI determines may be necessary to ascertain whether the recipient is complying with the Act and these regulations. (b) Provide to DOI, upon request...

43 CFR 17.337 - Remedial action by recipients.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Investigation, Conciliation, and Enforcement Procedures § 17.337 Remedial action by recipients. Where DOI finds... DOI may require to overcome the effects of the discrimination. If another recipient exercises control over the recipient that has discriminated, DOI may require both recipients to take remedial action. ...

Biogeography of key mesozooplankton species in the North Atlantic, by manual counting methods, and egg production of Calanus finmarchicus

NASA Astrophysics Data System (ADS)

Melle, W.; Runge, J. A.; Head, E.; Plourde, S.; Castellani, C.; Licandro, P.; Pierson, J.; Jonasdottir, S. H.; Johnson, C.; Broms, C.; Debes, H.; Falkenhaug, T.; Gaard, E.; Gislason, A.; Heath, M. R.; Niehoff, B.; Nielsen, T. G.; Pepin, P.; Stenevik, E. K.; Chust, G.

2014-04-01

Here we present a new, pan-Atlantic compilation of data on key mesozooplankton species, including the possibly most important copepod, Calanus finmarchicus. Distributional data of ten representative zooplankton taxa, from recent (2000-2009) Continuous Plankton Recorder data, are presented, along with basin-scale data of the phytoplankton colour index. Then we present a compilation of data on C. finmarchicus including observations of abundance, demography, egg production and female size with accompanying data on temperature and chlorophyll. This is a contribution by Canadian, European and US scientists and their institutions. http://doi.pangaea.de/10.1594/PANGAEA.820732, http://doi.pangaea.de/10.1594/PANGAEA.824423, http://doi.pangaea.de/10.1594/PANGAEA.828393.

A multiplexed TOF and DOI capable PET detector using a binary position sensitive network.

PubMed

Bieniosek, M F; Cates, J W; Levin, C S

2016-11-07

Time of flight (TOF) and depth of interaction (DOI) capabilities can significantly enhance the quality and uniformity of positron emission tomography (PET) images. Many proposed TOF/DOI PET detectors require complex readout systems using additional photosensors, active cooling, or waveform sampling. This work describes a high performance, low complexity, room temperature TOF/DOI PET module. The module uses multiplexed timing channels to significantly reduce the electronic readout complexity of the PET detector while maintaining excellent timing, energy, and position resolution. DOI was determined using a two layer light sharing scintillation crystal array with a novel binary position sensitive network. A 20 mm effective thickness LYSO crystal array with four 3 mm  ×  3 mm silicon photomultipliers (SiPM) read out by a single timing channel, one energy channel and two position channels achieved a full width half maximum (FWHM) coincidence time resolution of 180  ±  2 ps with 10 mm of DOI resolution and 11% energy resolution. With sixteen 3 mm  ×  3 mm SiPMs read out by a single timing channel, one energy channel and four position channels a coincidence time resolution 204  ±  1 ps was achieved with 10 mm of DOI resolution and 15% energy resolution. The methods presented here could significantly simplify the construction of high performance TOF/DOI PET detectors.

Large ORU/ Crane evaluations conducted during first EVA of STS-87 (DTO 671)

NASA Image and Video Library

1997-11-25

STS087-718-069 (19 November ? 5 December 1997) --- On the Space Shuttle Columbia's first ever spacewalk (EVA), astronaut Takao Doi works with a 156-pound crane carried onboard for the first time this trip of Columbia. The crane's inclusion and the work with it are part of a continuing preparation effort for future work on the International Space Station (ISS). The ongoing project allows for evaluation of tools and operating methods to be applied to the construction of the Space Station. This crane device is designed to aid future spacewalkers in transporting Orbital Replacement Units (ORU), with a mass up to 600 pounds (like the simulated battery pictured here), from translating carts on the exterior of ISS to various worksites on the truss structure. Earlier Doi, an international mission specialist representing Japan, and astronaut Winston E. Scott had installed the crane in a socket along the middle port side of Columbia's cargo bay for the evaluation. The two began the crane operations, long ago manifest for this mission, after completing a contingency spacewalk to snag the free-flying Spartan 201 and berth it in the payload bay (visible in the background).

PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms

PubMed Central

Mironova, Yevgeniya A; Lenk, Guy M; Lin, Jing-Ping; Lee, Seung Joon; Twiss, Jeffery L; Vaccari, Ilaria; Bolino, Alessandra; Havton, Leif A; Min, Sang H; Abrams, Charles S; Shrager, Peter; Meisler, Miriam H; Giger, Roman J

2016-01-01

Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is required in neurons and in OLs for normal CNS myelination. In mice, mutations of Fig4, Pikfyve or Vac14, encoding key components of the PI(3,5)P2 biosynthetic complex, each lead to impaired OL maturation, severe CNS hypomyelination and delayed propagation of compound action potentials. Primary OLs deficient in Fig4 accumulate large LAMP1+ and Rab7+ vesicular structures and exhibit reduced membrane sheet expansion. PI(3,5)P2 deficiency leads to accumulation of myelin-associated glycoprotein (MAG) in LAMP1+perinuclear vesicles that fail to migrate to the nascent myelin sheet. Live-cell imaging of OLs after genetic or pharmacological inhibition of PI(3,5)P2 synthesis revealed impaired trafficking of plasma membrane-derived MAG through the endolysosomal system in primary cells and brain tissue. Collectively, our studies identify PI(3,5)P2 as a key regulator of myelin membrane trafficking and myelinogenesis. DOI: http://dx.doi.org/10.7554/eLife.13023.001 PMID:27008179

KSC-07pd2833

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, STS-123 crew members get a close look at hardware related to the mission. They are at the center for a crew equipment interface test, which allows familiarization with equipment they will use during the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2832

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, STS-123 crew members get a close look at hardware related to the mission. They are at the center for a crew equipment interface test, which allows familiarization with equipment they will use during the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2827

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with the mission payload, the Kibo Experiment Logistics Module Pressurized Section. They are at the center for a crew equipment interface test, which allows familiarization with equipment they will use during the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis

KSC-07pd2828

NASA Image and Video Library

2007-10-11

KENNEDY SPACE CENTER, FLA. -- In the Space Station Processing Facility at NASA's Kennedy Space Center, members of the STS-123 crew get hands-on experience with the mission payload, the Kibo Experiment Logistics Module Pressurized Section. They are at the center for a crew equipment interface test, which allows familiarization with equipment they will use during the mission. Crew members are Commander Dominic Gorie, Pilot Gregory Johnson and Mission Specialists Richard Linnehan, Takao Doi, Robert Behnken, Gerrett Reisman and Michael Foreman. Doi represents the Japan Aerospace Exploration Agency. Reisman will remain on the space station after the mission as a flight engineer for Expedition 16. STS-123 will carry and install one of the components of the Japanese Experiment Module, or JEM. Known as Kibo, the JEM comprises six components: two research facilities -- the Pressurized Module and Exposed Facility; a Logistics Module attached to each of them; a Remote Manipulator System; and an Inter-Orbit Communication System unit. The various components of JEM will be assembled in space over the course of three space shuttle missions. The first of those three missions, STS-123, will carry the Experiment Logistics Module Pressurized Section aboard the space shuttle Endeavour, targeted for launch in February 2008. Photo credit: NASA/Dimitrios Gerondidakis