Computerized Buckling Analysis of Shells

DTIC Science & Technology

1981-06-01

principal elements of Koiter’s theory are outlined in the previous section. In his doctoral thesis published in 񓞹, Koiter shows that if certain...early 1960’s because the thesis was written in LM.. nJAl...t _CLrU1 6t AL. &Lý.A. >SL.2 LCL ._L L) . C r ~ n i: Ltia E;ULA.L ALb a 1JC~c&L~ cib atZ L...W. T., "Ovei de stabiliteit van het elastisch evenwicht," Delft thesis , H. J. Paris, Amsterdam; (English transl.) National - Aeronautics and Space

White House Science Fair

NASA Image and Video Library

2014-05-27

Bobak Ferdowsi, a system's engineer at NASA's Jet Propulsion Laboratory, speaks with a member of "invenTeam" at the White House Science Fair. Olivia Van Amsterdam, 16, Katelyn Sweeney, 17, and their team of student engineers from Natick, MA, invented a 120 lb remotely operated vehicle (ROV) that can help search-and-rescue dive teams search for bodies in dangerous, icy waters. The fourth White House Science Fair was held at the White House and included 100 students from more than 30 different states who competed in science, technology, engineering, and math (STEM) competitions. (Photo Credit: NASA/Aubrey Gemignani)

International Society for the Study of Fatty Acids and Lipids 2016 Debate: For Science-Based Dietary Guidelines on Fats, Meta-Analysis and Systematic Reviews Are Decisive.

PubMed

Nettleton, Joyce A; von Schacky, Clemens; Brouwer, Ingeborg A; Koletzko, Berthold

2017-01-01

This paper summarizes a debate on whether meta-analyses and systematic reviews are decisive in formulating guidelines for dietary fat. Held during the 12th congress of the International Society for the Study of Fatty Acids and Lipids in Stellenbosch, South Africa, September 7, 2016, the debate was hosted by the International Union of Nutritional Sciences and the International Expert Movement to Improve Dietary Fat Quality (IEM, www.theiem.org). Clemens von Schacky, Ludwig Maximilians-University, Munich, Germany, supported the statement, describing the types of weaknesses in individual studies and clinical trials. With examples of how to overcome such limitations, he concluded that nutritional guidelines on fat need a proper scientific basis in which randomized controlled trials (RCTs) with clinical endpoints and their meta-analyses are essential and decisive. In contention, Ingeborg Brouwer, Vrije Universiteit, Amsterdam, declared that recommendations on dietary fat intake should always be based on the totality of the evidence, including physiologic and biochemical knowledge and associations from observational epidemiology. RCTs and meta-analyses have their shortcomings, but well-conducted systematic reviews and meta-analyses support a transparent process for developing dietary fat guidelines. Participants agreed that evidence-based decision-making for dietary guidance should consider all the best available evidence using a transparent, systematic review. © 2017 The Author(s) Published by S. Karger AG, Basel.

On Teaching International Courses on Health Information Systems. Lessons Learned during 16 Years of Frank - van Swieten Lectures on Strategic Information Management in Health Information Systems.

PubMed

Ammenwerth, Elske; Knaup, Petra; Winter, Alfred; Bauer, Axel W; Bott, Oliver J; Gietzelt, Matthias; Haarbrandt, Birger; Hackl, Werner O; Hellrung, Nils; Hübner-Bloder, Gudrun; Jahn, Franziska; Jaspers, Monique W; Kutscha, Ulrike; Machan, Christoph; Oppermann, Bianca; Pilz, Jochen; Schwartze, Jonas; Seidel, Christoph; Slot, Jan-Eric; Smers, Stefan; Spitalewsky, Katharina; Steckel, Nathalie; Strübing, Alexander; van der Haak, Minne; Haux, Reinhold; Ter Burg, Willem J

2017-03-08

Health information systems (HIS) are one of the most important areas for biomedical and health informatics. In order to professionally deal with HIS well-educated informaticians are needed. Because of these reasons, in 2001 an international course has been established: The Frank - van Swieten Lectures on Strategic Information Management of Health Information Systems. Reporting about the Frank - van Swieten Lectures and about our students' feedback on this course during the last 16 years. Summarizing our lessons learned and making recommendations for such international courses on HIS. The basic concept of the Frank - van Swieten lectures is to teach the theoretical background in local lectures, to organize practical exercises on modelling sub-information systems of the respective local HIS and finally to conduct Joint Three Days as an international meeting were the resulting models are introduced and compared. During the last 16 years, the Universities of Amsterdam, Braunschweig, Heidelberg/Heilbronn, Leipzig as well as UMIT were involved in running this course. Overall, 517 students from these universities participated. Our students' feedback was clearly positive. The Joint Three Days of the Frank - van Swieten Lectures, where at the end of the course all students can meet, turned out to be an important component of this course. Based on the last 16 years, we recommend common teaching materials, agreement on equivalent clinical areas for the exercises, support of group building of international student groups, motivation of using a collaboration platform, ensuring quality management of the course, addressing different levels of knowledge of the students, and ensuring sufficient funding for joint activities. Although associated with considerable additional efforts, we can clearly recommend establishing such international courses on HIS, such as the Frank - van Swieten Lectures.

Remotely sensed forest phenology and its relation with Nephropathia

NASA Astrophysics Data System (ADS)

Barrios, J. M.

2010-05-01

J.M. Barrios1, W.W. Verstraeten1, P. Maes2, J. Clement2, J-M. Aerts1, S. Amirpour1, J. Wambacq2, K. Lagrou3, M. Van Ranst2, D. Berckmans1, P. Coppin1 1. Katholieke Universiteit Leuven, Biosystems Departement, M3-BIORES, Willem de Croylaan 34, B-3001 Leuven, Belgium 2. Katholieke Universiteit Leuven, Laboratory of Clinical Virology, Hantavirus Reference Center, Rega Institute, Minderbroedersstraat 10, B-3000 Leuven, Belgium 3. Katholieke Universiteit Leuven, Department of Experimental Laboratory Medicine, Herestraat 49, B-3000 Leuven, Belgium Nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome, is a zoonotic disease caused by a Hanta virus called Puumala virus in Europe. Concern about this disease has increased in recent years due to the increase in the amount of reported cases. In 2005, 2007 and 2008 the number of infected cases surpassed 300 cases per 100000 inhabitants in Belgium, which was never observed before. NE incidence is closely related to environmental conditions. The main role in the virus transmission mechanism is played by the red bank vole (Myodes glareolus), a rodent species that is native in West European broad-leaved forests (BLF) and acts as the virus reservoir. Although the link between vegetation and NE in Belgium has been underlined repeatedly in recent research works, so far little has been done towards the exploration of remote sensing techniques for analyzing vegetation systems as an input in early warning systems. This study aims at determining whether observed NE occurrence pattern in Belgium can be connected to specific trends in BLF phenology parameters. Hence, phenology information was derived from time series of the MODIS Enhanced Vegetation Index (EVI) for the period 2000-2008 in 10 major BLF in southern Belgium. EVI values were calculated from the MOD09A1 dataset which provides an estimate of the surface spectral reflectance for bands 1-7 at 500 m resolution every 8 days. Based on our preliminary results, it is concluded that one of the most remarkable phenomena taking place in BLF is the gradual increase in length of the growing season in the 2000-2007 period. This is supported by international literature. Increasing growing seasons might contribute to an increase in the availability of resources to sustain large rodent populations and in the prolongation of optimal conditions for breeding. For most of the sampled sites, the years preceding peaks in NE cases (2005, 2008) were characterised by a late end of the growing season which coincides with warmer fall seasons. This research is part of a larger effort that aims at the incorporation of remotely sensed data in the prediction and monitoring of epidemiologic diseases.

Outbreak of Bacillus cereus infections in a neonatal intensive care unit traced to balloons used in manual ventilation.

PubMed

Van Der Zwet, W C; Parlevliet, G A; Savelkoul, P H; Stoof, J; Kaiser, A M; Van Furth, A M; Vandenbroucke-Grauls, C M

2000-11-01

In 1998, an outbreak of systemic infections caused by Bacillus cereus occurred in the Neonatal Intensive Care Unit of the University Hospital Vrije Universiteit, Amsterdam, The Netherlands. Three neonates developed sepsis with positive blood cultures. One neonate died, and the other two neonates recovered. An environmental survey, a prospective surveillance study of neonates, and a case control study were performed, in combination with molecular typing, in order to identify potential sources and transmission routes of infection. Genotypic fingerprinting by amplified-fragment length polymorphism (AFLP) showed that the three infections were caused by a single clonal type of B. cereus. The same strain was found in trachea aspirate specimens of 35 other neonates. The case control study showed mechanical ventilation with a Sensormedics ventilation machine to be a risk factor for colonization and/or infection (odds ratio, 9.8; 95% confidence interval, 1.1 to 88.2). Prospective surveillance showed that colonization with B. cereus occurred exclusively in the respiratory tract of mechanically ventilated neonates. The epidemic strain of B. cereus was found on the hands of nursing staff and in balloons used for manual ventilation. Sterilization of these balloons ended the outbreak. We conclude that B. cereus can cause outbreaks of severe opportunistic infection in neonates. Typing by AFLP proved very useful in the identification of the outbreak and in the analysis of strains recovered from the environment to trace the cause of the epidemic.

Outbreak of Bacillus cereus Infections in a Neonatal Intensive Care Unit Traced to Balloons Used in Manual Ventilation

PubMed Central

Van Der Zwet, Wil C.; Parlevliet, Gerard A.; Savelkoul, Paul H.; Stoof, Jeroen; Kaiser, Annie M.; Van Furth, A. Marceline; Vandenbroucke-Grauls, Christina M.

2000-01-01

In 1998, an outbreak of systemic infections caused by Bacillus cereus occurred in the Neonatal Intensive Care Unit of the University Hospital Vrije Universiteit, Amsterdam, The Netherlands. Three neonates developed sepsis with positive blood cultures. One neonate died, and the other two neonates recovered. An environmental survey, a prospective surveillance study of neonates, and a case control study were performed, in combination with molecular typing, in order to identify potential sources and transmission routes of infection. Genotypic fingerprinting by amplified-fragment length polymorphism (AFLP) showed that the three infections were caused by a single clonal type of B. cereus. The same strain was found in trachea aspirate specimens of 35 other neonates. The case control study showed mechanical ventilation with a Sensormedics ventilation machine to be a risk factor for colonization and/or infection (odds ratio, 9.8; 95% confidence interval, 1.1 to 88.2). Prospective surveillance showed that colonization with B. cereus occurred exclusively in the respiratory tract of mechanically ventilated neonates. The epidemic strain of B. cereus was found on the hands of nursing staff and in balloons used for manual ventilation. Sterilization of these balloons ended the outbreak. We conclude that B. cereus can cause outbreaks of severe opportunistic infection in neonates. Typing by AFLP proved very useful in the identification of the outbreak and in the analysis of strains recovered from the environment to trace the cause of the epidemic. PMID:11060080

On Teaching International Courses on Health Information Systems

PubMed Central

Bauer, Axel W.; Bott, Oliver J.; Gietzelt, Matthias; Haarbrandt, Birger; Hackl, Werner O.; Hellrung, Nils; Hübner-Bloder, Gudrun; Jahn, Franziska; Jaspers, Monique W.; Kutscha, Ulrike; Machan, Christoph; Oppermann, Bianca; Pilz, Jochen; Schwartze, Jonas; Seidel, Christoph; Slot, Jan-Eric; Smers, Stefan; Spitalewsky, Katharina; Steckel, Nathalie; Strübing, Alexander; van der Haak, Minne

2017-01-01

Summary Background Health information systems (HIS) are one of the most important areas for biomedical and health informatics. In order to professionally deal with HIS well-educated informaticians are needed. Because of these reasons, in 2001 an international course has been established: The Frank – van Swieten Lectures on Strategic Information Management of Health Information Systems. Objectives Reporting about the Frank – van Swieten Lectures and about our students‘ feedback on this course during the last 16 years. Summarizing our lessons learned and making recommendations for such international courses on HIS. Methods The basic concept of the Frank – van Swieten lectures is to teach the theoretical background in local lectures, to organize practical exercises on modelling sub-information systems of the respective local HIS and finally to conduct Joint Three Days as an international meeting were the resulting models are introduced and compared. Results During the last 16 years, the Universities of Amsterdam, Braunschweig, Heidelberg/Heilbronn, Leipzig as well as UMIT were involved in running this course. Overall, 517 students from these universities participated. Our students‘ feedback was clearly positive. The Joint Three Days of the Frank – van Swieten Lectures, where at the end of the course all students can meet, turned out to be an important component of this course. Based on the last 16 years, we recommend common teaching materials, agreement on equivalent clinical areas for the exercises, support of group building of international student groups, motivation of using a collaboration platform, ensuring quality management of the course, addressing different levels of knowledge of the students, and ensuring sufficient funding for joint activities. Conclusions Although associated with considerable additional efforts, we can clearly recommend establishing such international courses on HIS, such as the Frank – van Swieten Lectures. PMID:28272648

PREFACE: Proceedings of the 25th International Conference on Low Temperature Physics (LT25) (Amsterdam, The Netherlands, 6-13 August 2008) Proceedings of the 25th International Conference on Low Temperature Physics (LT25) (Amsterdam, The Netherlands, 6-13 August 2008)

NASA Astrophysics Data System (ADS)

Kes, Peter; Jochemsen, Reijer

2009-04-01

This issue forms part I of the Proceedings of the 25th International Conference on Low Temperature Physics (LT25) (Amsterdam, The Netherlands, 67-13 August 2008). The majority of the special invited lectures, such as the London prize lectures, the international union of pure and applied physics (IUPAP) young scientist award lectures, the plenary, half-plenary and public lectures, and the historical lectures presented at the LT25 conference, are included. The papers relating to the oral and poster presentations will appear in part II of the proceedings in a dedicated open access issue of Journal of Physics: Conference Series (2009 J. Phys.: Conf. Ser. 150). In addition to the organizer's report and a summary of the new developments in low temperature physics, which can also be found in this issue, part II provides useful information about LT25, such as an overview of committees, sponsors, exhibitors, and some conference statistics. To ensure the high publication standard mandated by Journal of Physics: Condensed Matter and Journal of Physics: Conference Series every paper was reviewed by at least one referee before it was accepted for publication. The editors are indebted to many colleagues for invaluable assistance in the preparation and review of 900 papers appearing in both parts I and II of these proceedings. In particular, we would like to thank Carlo Beenakker, Jeroen van den Brink, Hans Brom, Jos de Jongh, Horst Rogalla, Fons de Waele, and Jan Zaanen.

In-training assessment: qualitative study of effects on supervision and feedback in an undergraduate clinical rotation.

PubMed

Daelmans, H E M; Overmeer, R M; van der Hem-Stokroos, H H; Scherpbier, A J J A; Stehouwer, C D A; van der Vleuten, C P M

2006-01-01

Supervision and feedback are essential factors that contribute to the learning environment in the context of workplace learning and their frequency and quality can be improved. Assessment is a powerful tool with which to influence students' learning and supervisors' teaching and thus the learning environment. To investigate an in-training assessment (ITA) programme in action and to explore its effects on supervision and feedback. A qualitative study using individual, semistructured interviews. Eight students and 17 assessors (9 members of staff and 8 residents) in the internal medicine undergraduate clerkship at Vrije Universiteit Medical Centre, Amsterdam, the Netherlands. The ITA programme in action differed from the intended programme. Assessors provided hardly any follow-up on supervision and feedback given during assessments. Although students wanted more supervision and feedback, they rarely asked for it. Students and assessors failed to integrate the whole range of competencies included in the ITA programme into their respective learning and supervision and feedback. When giving feedback, assessors rarely gave borderline or fail judgements. If an ITA programme in action is to be congruent with the intended programme, the implementation of the programme must be monitored. It is also necessary to provide full information about the programme and to ensure this information is given repeatedly. Introducing an ITA programme that includes the assessment of several competencies does not automatically lead to more attention being paid to these competencies in terms of supervision and feedback. Measures that facilitate change in the learning environment seem to be a prerequisite for enabling the assessment programme to steer the learning environment.

Improving World Agricultural Supply and Demand Estimates by Integrating NASA Remote Sensing Soil Moisture Data into USDA World Agricultural Outlook Board Decision Making Environment

NASA Astrophysics Data System (ADS)

Teng, W. L.; de Jeu, R. A.; Doraiswamy, P. C.; Kempler, S. J.; Shannon, H. D.

2009-12-01

A primary goal of the U.S. Department of Agriculture (USDA) is to expand markets for U.S. agricultural products and support global economic development. The USDA World Agricultural Outlook Board (WAOB) supports this goal by developing monthly World Agricultural Supply and Demand Estimates (WASDE) for the U.S. and major foreign producing countries. Because weather has a significant impact on crop progress, conditions, and production, WAOB prepares frequent agricultural weather assessments, in a GIS-based, Global Agricultural Decision Support Environment (GLADSE). The main objective of this project, thus, is to improve WAOB's estimates by integrating NASA remote sensing soil moisture observations and research results into GLADSE. Soil moisture is a primary data gap at WAOB. Soil moisture data, generated by the Land Parameter Retrieval Model (LPRM, developed by NASA GSFC and Vrije Universiteit Amsterdam) and customized to WAOB's requirements, will be directly integrated into GLADSE, as well as indirectly by first being integrated into USDA Agricultural Research Service (ARS)'s Environmental Policy Integrated Climate (EPIC) crop model. The LPRM-enhanced EPIC will be validated using three major agricultural regions important to WAOB and then integrated into GLADSE. Project benchmarking will be based on retrospective analyses of WAOB's analog year comparisons. The latter are between a given year and historical years with similar weather patterns. WAOB is the focal point for economic intelligence within the USDA. Thus, improving WAOB's agricultural estimates by integrating NASA satellite observations and model outputs will visibly demonstrate the value of NASA resources and maximize the societal benefits of NASA investments.

A novel approach to validate satellite soil moisture retrievals using precipitation data

NASA Astrophysics Data System (ADS)

Karthikeyan, L.; Kumar, D. Nagesh

2016-10-01

A novel approach is proposed that attempts to validate passive microwave soil moisture retrievals using precipitation data (applied over India). It is based on the concept that the expectation of precipitation conditioned on soil moisture follows a sigmoidal convex-concave-shaped curve, the characteristic of which was recently shown to be represented by mutual information estimated between soil moisture and precipitation. On this basis, with an emphasis over distribution-free nonparametric computations, a new measure called Copula-Kernel Density Estimator based Mutual Information (CKDEMI) is introduced. The validation approach is generic in nature and utilizes CKDEMI in tandem with a couple of proposed bootstrap strategies, to check accuracy of any two soil moisture products (here Advanced Microwave Scanning Radiometer-EOS sensor's Vrije Universiteit Amsterdam-NASA (VUAN) and University of Montana (MONT) products) using precipitation (India Meteorological Department) data. The proposed technique yields a "best choice soil moisture product" map which contains locations where any one of the two/none of the two/both the products have produced accurate retrievals. The results indicated that in general, VUA-NASA product has performed well over University of Montana's product for India. The best choice soil moisture map is then integrated with land use land cover and elevation information using a novel probability density function-based procedure to gain insight on conditions under which each of the products has performed well. Finally, the impact of using a different precipitation (Asian Precipitation-Highly-Resolved Observational Data Integration Towards Evaluation of Water Resources) data set over the best choice soil moisture product map is also analyzed. The proposed methodology assists researchers and practitioners in selecting the appropriate soil moisture product for various assimilation strategies at both basin and continental scales.

Computer-Aided Engineering Education at the K.U. Leuven.

ERIC Educational Resources Information Center

Snoeys, R.; Gobin, R.

1987-01-01

Describes some recent initiatives and developments in the computer-aided design program in the engineering faculty of the Katholieke Universiteit Leuven (Belgium). Provides a survey of the engineering curriculum, the computer facilities, and the main software packages available. (TW)

Amsterdam, Netherlands

NASA Image and Video Library

2012-11-26

Amsterdam is the largest city and the capital of the Netherlands. Its name derives from a dam in the river Amstel. Founded in the 12th century as a fishing village, Amsterdam was one of the most important ports in the world in the 17th century.

[Utility of diagnostic scales for hereditary non-polyposis colon cancer in the Mexican population].

PubMed

Mendoza Sánchez, Andrés; Sobrino Cossio, Sergio; Hernández Guerrero, Angélica; Córdova Pluma, Víctor Hugo; Alonso Lárraga, Octavio; Sánchez del Monte, D r Julio

2005-01-01

Hereditary non-polyposis colorectal cancer (HNPCC) represents 2 - 7% of all cancers. Diagnosis is made by means of the Amstedam criteria, or the modified Amsterdam and Bethesda. Aim was to evaluate the clinical application of the diagnostic scales for HNPCC in our population and to determine the clinical characteristics that these patients reveal at the time of diagnosis. A retrospective, cross-sectional study in which patients with colon cancer and less than 50 years of age were evaluated in a period of 3 years. The demographic data, patients and relatives history and the characteristics of the tumor were obtained at the time of diagnosis. We applied the Amsterdam criteria, modified Amsterdam and Bethesda to all the patients. 56 of 210 patients were of 50 younger with an average age of 38.3 years. Among the patients 14.3% had familiar cancer history. In 53.6% the tumor was located in right colon, regardless histology they had mucin component and poor cellular differentiation. Only two patients fulfilled criteria of modified Amsterdam and Amsterdam, and no patient fulfilled the Bethesda criteria. Frequency of CCNPH in our population was 1% by the Amsterdam criteria and modified Amsterdam and 0% by the Bethesda criteria.

Utilizing the "Plan, Do, Study, Act" Framework to Explore the Process of Curricular Assessment and Redesign in a Physical Therapy Education Program in Suriname.

PubMed

Audette, Jennifer Gail; Baldew, Se-Sergio; Chang, Tony C M S; de Vries, Jessica; Ho A Tham, Nancy; Janssen, Johanna; Vyt, Andre

2017-01-01

To describe how a multinational team worked together to transition a physical therapy (PT) educational program in Paramaribo, Suriname, from a Bachelor level to a Master of Science in Physical Therapy (MSPT) level. The team was made up of PT faculty from Anton De Kom Universiteit van Suriname (AdeKUS), the Flemish Interuniversity Council University Development Cooperation (VLIR-UOS) leadership, and Health Volunteers Overseas volunteers. In this case study, the process for curricular assessment, redesign, and upgrade is described retrospectively using a Plan, Do, Study, Act (PDSA) framework. PT educational programs in developing countries are eager for upgrade to meet international expectations and to better meet community health-care needs. An ongoing process which included baseline assessment of all aspects of the existing bachelor's program in PT, development of a plan for a MSPT, implementation of the master's program, and evaluation following implementation is described. Curricular assessment and upgrade in resource-limited countries requires the implementation of process-oriented methods. The PDSA process is a useful tool to explore curricular development. The international collaboration described in this paper provides an example of the diligence, consistency, and dedication required to see a project through and achieve success while providing adequate support to the host site. This project might provide valuable insights for those involved in curricular redesign in similar settings.

The Amsterdam declaration on fungal nomenclature

USDA-ARS?s Scientific Manuscript database

The Amsterdam Declaration on Fungal Nomenclature was developed at a international symposium convened in Amsterdam on 19-20 April 2011 under the auspices of the International Commission on the Taxonomy of Fungi (ICTF). The purpose of the symposium was to address the issue of whether or how the curren...

Additional value of typing Noroviruses in gastroenteritis outbreaks in Amsterdam, The Netherlands.

PubMed

Koek, A G; Bovée, L P M J; van den Hoek, J A R; Bos, A J; Bruisten, S M

2006-02-01

In Amsterdam, 17 of the 55 gastroenteritis (GI) outbreaks reported from January 2002 to May 2003 were confirmed to be caused by noroviruses (NV). In this study, we describe the molecular epidemiology of a group of nine outbreaks associated with a catering firm and two outbreaks, 5 months apart, in an Amsterdam hospital. All outbreaks were typed to confirm their linkage, and the hospital-related cases were studied to see if the two outbreaks were caused by one persisting NV strain or by a reintroduction after 5 months. For the outbreaks associated with the catering firm one NV genogroup I strain was found which was identical in sequence among customers and employees of the caterer. This was not the strain that predominantly circulated in 2002/2003 in and around Amsterdam, which was the NV genogroup II4 "new variant" (GgII4nv) strain. In the Amsterdam hospital, the two outbreaks were caused by this predominant GgII4nv type, and we argue that NV was most likely reintroduced in the second outbreak from the Amsterdam community.

Metaphor Identification as a Research Method for the Study of Career

ERIC Educational Resources Information Center

Creed, Allison; McIlveen, Peter

2018-01-01

In this paper, we present the Metaphor Identification Procedure Vrije Universiteit (MIPVU) for the reliable detection of metaphoric language that may be interpreted using extant vocational psychology theory. Metaphors are ubiquitous in communication and carry influential meaning for people. To illustrate MIPVU, we use transcripts of interviews…

Speaking of Belonging: Learning to Be "Good Citizens" in the Context of Voluntary Language Coaching Projects in Amsterdam, the Netherlands

ERIC Educational Resources Information Center

Mosher, Rhiannon

2015-01-01

This article explores citizenship education for adult immigrants through informal language education in Amsterdam, the Netherlands. Based on data collected over thirteen months of ethnographic research among volunteer Dutch language coaches in Amsterdam, the primary methods used in this study were in-depth semi-structured interviews and…

Quality of care for patients with type 2 diabetes mellitus in the Netherlands and the United States: a comparison of two quality improvement programs.

PubMed

Valk, Gerlof D; Renders, Carry M; Kriegsman, Didi M W; Newton, Katherine M; Twisk, Jos W R; van Eijk, Jacques Th M; van der Wal, Gerrit; Wagner, Edward H

2004-08-01

To assess differences in diabetes care and patient outcomes by comparing two multifaceted quality improvement programs in two different countries, and to increase knowledge of effective elements of such programs. Primary care in the ExtraMural Clinic (EMC) of the Department of General Practice of the Vrije Universiteit in Amsterdam, the Netherlands, and the Group Health Cooperative (GHC), a group-model health maintenance organization (HMO) in western Washington State in the United States. Data were collected from 1992 to 1997. In this observational study two diabetes cohorts in which a quality improvement program was implemented were compared. Both programs included a medical record system, clinical practice guidelines, physician educational meetings, audit, and feedback. Only the Dutch program (EMC) included guidelines on the structure of diabetes care and a recall system. Only the GHC program included educational outreach visits, formation of multidisciplinary teams, and patient self-management support. Included were 379 EMC patients, and 2,119 GHC patients with type 2 diabetes mellitus. Main process outcomes were: annual number of diabetes visits, and number of HbA1c and blood lipid measurements. Main patient outcomes were HbA1c and blood lipid levels. Multilevel analysis was used to adjust for dependency between repeated observations within one patient and for clustering of patients within general practices. In the EMC process outcomes and glycemic control improved more than at GHC, however, GHC had better baseline measures. There were no differences between programs on blood lipid control. During follow-up, intensification of pharmacotherapy was noted at both sites. Differences noted between programs were in line with differences in diabetes guidelines. Following implementation of guidelines and organizational improvement efforts, change occurred primarily in the process outcomes, rather than in the patient outcomes. Although much effort was put into improving process and patient outcomes, both complex programs still showed only moderate effects.

Online Self-Administered Cognitive Testing Using the Amsterdam Cognition Scan: Establishing Psychometric Properties and Normative Data.

PubMed

Feenstra, Heleen Em; Vermeulen, Ivar E; Murre, Jaap Mj; Schagen, Sanne B

2018-05-30

Online tests enable efficient self-administered assessments and consequently facilitate large-scale data collection for many fields of research. The Amsterdam Cognition Scan is a new online neuropsychological test battery that measures a broad variety of cognitive functions. The aims of this study were to evaluate the psychometric properties of the Amsterdam Cognition Scan and to establish regression-based normative data. The Amsterdam Cognition Scan was self-administrated twice from home-with an interval of 6 weeks-by 248 healthy Dutch-speaking adults aged 18 to 81 years. Test-retest reliability was moderate to high and comparable with that of equivalent traditional tests (intraclass correlation coefficients: .45 to .80; .83 for the Amsterdam Cognition Scan total score). Multiple regression analyses indicated that (1) participants' age negatively influenced all (12) cognitive measures, (2) gender was associated with performance on six measures, and (3) education level was positively associated with performance on four measures. In addition, we observed influences of tested computer skills and of self-reported amount of computer use on cognitive performance. Demographic characteristics that proved to influence Amsterdam Cognition Scan test performance were included in regression-based predictive formulas to establish demographically adjusted normative data. Initial results from a healthy adult sample indicate that the Amsterdam Cognition Scan has high usability and can give reliable measures of various generic cognitive ability areas. For future use, the influence of computer skills and experience should be further studied, and for repeated measurements, computer configuration should be consistent. The reported normative data allow for initial interpretation of Amsterdam Cognition Scan performances. ©Heleen EM Feenstra, Ivar E Vermeulen, Jaap MJ Murre, Sanne B Schagen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 30.05.2018.

Amsterdam's STI/HIV Programme: An Innovative Strategy to Achieve and Enhance the Participation of Migrant Community-Based Organisations

ERIC Educational Resources Information Center

Wagemakers, Annemarie; van Husen, Gwen; Barrett, Jennifer B.; Koelen, Maria A.

2015-01-01

Objective: The STI/HIV prevention programme in Amsterdam aims to improve the sexual health of Amsterdam residents of African, Antillean, Aruban and Surinamese origins. The programme strategy is to achieve and enhance the participation of migrant community-based organisations (CBOs) in sexual health promotion through a grant scheme and by providing…

Hubble's Panoramic View of a Turbulent Star-Making Region

NASA Image and Video Library

2017-12-08

NASA image release date April 17, 2012 This region resembles a coral reef, but the gas has been eroded by the hefty stars in R136, situated above it. Cloaked in gas at the top of this rugged, gaseous terrain are nascent stars that cannot be seen. Dense columns of gas, several light-years long, protrude from the undulating landscape. These gaseous columns are incubators for developing stars. 30 Doradus is the brightest, nearby star-forming region and home to the most massive stars in our cosmic neighborhood of about 25 galaxies. The nebula is close enough to Earth that Hubble can resolve individual stars, giving astronomers important information about the stars' birth and evolution. 30 Doradus resides 170,000 light-years away in the Large Magellanic Cloud, a small, satellite galaxy of our Milky Way. To read more go to: www.nasa.gov/mission_pages/hubble/science/30doradus.html Credit: NASA, ESA, D. Lennon and E. Sabbi (ESA/STScI), J. Anderson, S. E. de Mink, R. van der Marel, T. Sohn, and N. Walborn (STScI), N. Bastian (Excellence Cluster, Munich), L. Bedin (INAF, Padua), E. Bressert (ESO), P. Crowther (University of Sheffield), A. de Koter (University of Amsterdam), C. Evans (UKATC/STFC, Edinburgh), A. Herrero (IAC, Tenerife), N. Langer (AifA, Bonn), I. Platais (JHU), and H. Sana (University of Amsterdam) NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Improving the Algae Bloom Prediction through the Assimilation of the Remotely Sensed Chlorophyll-A Data in a Generic Ecological Model in the North Sea

NASA Astrophysics Data System (ADS)

El Serafy, Ghada

2010-05-01

Harmful algae can cause damage to co-existing organisms, tourism and farmers. Accurate predictions of algal future composition and abundance as well as when and where algal blooms may occur could help early warning and mitigating. The Generic Ecological Model, GEM, [Blauw et al 2008] is an instrument that can be applied to any water system (fresh, transitional or coastal) to calculate the primary production, chlorophyll-a concentration and phytoplankton species composition. It consists of physical, chemical and ecological model components which are coupled together to build one generic and flexible modeling tool. For the North Sea, the model has been analyzed to assess sensitivity of the simulated chlorophyll-a concentration to a subset of ecologically significant set of factors. The research led to the definition of the most significant set of parameters to the algae blooming process in the North Sea [Salacinska et al 2009]. In order to improve the prediction of the model, the set of parameters and the chlorophyll-a concentration can be further estimated through the use of data assimilation. In this research, the Ensemble Kalman Filter (EnKF) data assimilation technique is used to assimilate the chlorophyll-a data of the North Sea, retrieved from MEdium Resolution Imaging Sensor (MERIS) spectrometer data [Peters et al 2005], in the GEM model. The chlorophyll-a data includes concentrations and error information that enable their use in data assimilation. For the same purpose, the uncertainty of the ecological generic model, GEM has been quantified by means of Monte Carlo approach. Through a study covering the year of 2003, the research demonstrates that both data and model are sufficiently robust for a successful assimilation. The results show that through the assimilation of the satellite data, a better description of the algae bloom has been achieved and an improvement of the capability of the model to predict the algae bloom for the North Sea has been confirmed. Blauw A.N., Los F.J., Bokhorst M., Erftemeijer P.L.A., (2009), GEM: a Generic Ecological Model for estuaries and coastal waters. Journal of Hydrobiologia, Volume 618, Number 1, 175-198. Peters, S.W.M., Eleveld, M. Pasterkamp, R., Woerd, H. van der, Devolder, M., Jans, S., Park, Y., Ruddick, K., Block, T., Brockmann, C., Doerffer, R., Krasemann, H., Röttgers, R., Schönfeld, W., Jørgensen, P.V., Tilstone, G., Martinez-Vicente, V., Moore, G., Sørensen, K., Høkedal, J., Johnsen, T.M., Lømsland, E.R., Aas, E. (2005). Atlas of Chlorophyll-a concentration for the North Sea based on MERIS imagery of 2003. IVM report, Vrije Universiteit Amsterdam, 117 pp. ISBN 90-5192-026-1. Salacinska K., El Serafy G.Y., Blauw A., Los F.J., (2009) Sensitivity analysis of the two dimensional application of the Generic Ecological Model (GEM) to algal bloom prediction in the North Sea, Journal of Ecological Modeling, volume 221, 7, pp 178-190, DOI: 10.1016/j.ecolmodel.2009.10.001

Comparison of general health status, myocardial infarction, obesity, diabetes, and fruit and vegetable intake between immigrant Pakistani population in the Netherlands and the local Amsterdam population.

PubMed

Raza, Qaisar; Nicolaou, Mary; Dijkshoorn, Henriëtte; Seidell, Jacob C

2017-12-01

South Asians living in Western countries have shown higher prevalence of cardiovascular disease and related non-communicable diseases as compared to the local populations. The aim of this study was to compare the general health status and prevalence of myocardial infarction (MI), diabetes, high blood pressure, overweight, obesity, and fruit and vegetable intake between Pakistani immigrants in the Netherlands and local Amsterdam population. A health survey was conducted in 2012-2013 among Pakistanis in the Netherlands. Results were compared with a health survey conducted among inhabitants of Amsterdam in 2012. One hundred and fifty-four Pakistanis from four big cities of the Netherlands and 7218 inhabitants of Amsterdam participated. The data for Amsterdam population were weighed on the basis of age, gender, city district, marital status, ethnicity and income level while the data for Pakistanis were weighed on the basis of age and gender to make both data-sets representative of their general population. Pakistanis reported a high prevalence of MI (3.3%), diabetes (11.4%), high blood pressure (14.4%), overweight (35.5%) and obesity (18.5%) while Amsterdam population reported the prevalence as 2.5% for MI, 6.8% for diabetes, 15.3% for high blood pressure, 28.1% for overweight and 11.1% for obesity. Pakistanis had a significantly higher level of MI (OR = 2.71; 95% CI: 1.19-6.14), diabetes (OR = 4.41; 95% CI: 2.66-7.33) and obesity (OR = 2.51; 95% CI: 1.53-4.12) after controlling for age, sex and educational level with Amsterdam population as the reference group. Pakistanis showed a higher intake of fruit and fruit juice as compared to Amsterdam population though the latter showed a higher intake of cooked vegetables. Higher prevalence of MI, diabetes and obesity among Pakistanis than Amsterdam population indicates the need for health scientists and policy-makers to develop interventions for tackling non-communicable diseases and its determinants among Pakistanis living in the Netherlands.

The meaning of "significance" for different types of research [translated and annotated by Eric-Jan Wagenmakers, Denny Borsboom, Josine Verhagen, Rogier Kievit, Marjan Bakker, Angelique Cramer, Dora Matzke, Don Mellenbergh, and Han L. J. van der Maas]. 1969.

PubMed

de Groot, A D

2014-05-01

Adrianus Dingeman de Groot (1914-2006) was one of the most influential Dutch psychologists. He became famous for his work "Thought and Choice in Chess", but his main contribution was methodological--De Groot co-founded the Department of Psychological Methods at the University of Amsterdam (together with R. F. van Naerssen), founded one of the leading testing and assessment companies (CITO), and wrote the monograph "Methodology" that centers on the empirical-scientific cycle: observation-induction-deduction-testing-evaluation. Here we translate one of De Groot's early articles, published in 1956 in the Dutch journal Nederlands Tijdschrift voor de Psychologie en Haar Grensgebieden. This article is more topical now than it was almost 60years ago. De Groot stresses the difference between exploratory and confirmatory ("hypothesis testing") research and argues that statistical inference is only sensible for the latter: "One 'is allowed' to apply statistical tests in exploratory research, just as long as one realizes that they do not have evidential impact". De Groot may have also been one of the first psychologists to argue explicitly for preregistration of experiments and the associated plan of statistical analysis. The appendix provides annotations that connect De Groot's arguments to the current-day debate on transparency and reproducibility in psychological science. Copyright © 2014 Elsevier B.V. All rights reserved.

Instruments of Science and Citizenship: Science Education for Dutch Orphans During the Late Eighteenth Century

NASA Astrophysics Data System (ADS)

Roberts, Lissa L.

2012-01-01

One of the two most extensive instrument collections in the Netherlands during the second half of the eighteenth century—rivaling the much better known collection at the University of Leiden—belonged to an orphanage in The Hague that was specially established to mold hand-picked orphans into productive citizens. (The other was housed at the Mennonite Seminary in Amsterdam, for use in the education of its students.) The educational program at this orphanage, one of three established by the Fundatie van Renswoude, grew out of a marriage between the socially-oriented generosity of the wealthy Baroness van Renswoude and the pedagogical vision of the institute's director and head teacher—a vision that fit with the larger movement of oeconomic patriotism. Oeconomic patriotism, similar to `improvement' and oeconomic movements in other European countries and their colonies, sought to tie the investigation of nature to an improvement of society's material and moral well-being. Indeed, it was argued that these two facets of society should be viewed as inseparable from each other, distinguishing the movement from more modern conceptions of economics. While a number of the key figures in this Dutch movement also became prominent Patriots during the revolutionary period at the end of the century, fighting against the House of Orange, they did not have a monopoly on oeconomic ideas of societal improvement. This is demonstrated by the fact that an explicitly pro-Orangist society, Mathesis Scientiarum Genitrix, was organized in 1785 to teach science and mathematics to poor boys and orphans for very similar reasons: to turn them into productive and useful citizens. As was the case with the Fundatie van Renswoude, a collection of instruments was assembled to help make this possible. This story is of interest because it discusses a hitherto under-examined use to which science education was put during this period, by revealing the link between such programs and the highly charged question of citizenry.

Problem Solving and Engineering Design, Introducing Bachelor Students to Engineering Practice at K. U. Leuven

ERIC Educational Resources Information Center

Heylen, Christel; Smet, Marc; Buelens, Hermans; Sloten, Jos Vander

2007-01-01

A present-day engineer has a large scientific knowledge; he is a team-player, eloquent communicator and life-long learner. At the Katholieke Universiteit Leuven, the course "Problem Solving and Engineering Design" introduces engineering students from the first semester onwards into real engineering practice and teamwork. Working in small…

"New Education" for the Congo? The Indigenist Approach, New Education and Prescriptive Pedagogy

ERIC Educational Resources Information Center

Depaepe, Marc; Simon, Frank; Vinck, Honoré

2015-01-01

This article responds to a question put forward approximately a decade ago by the history of education research group at the Katholieke Universiteit Leuven: Did the child-centred ideas of New Education, as promoted by Ovide Decroly, influence the education policy in the former Belgian colony of Congo? Naturally, ideas were circulating that could…

Speleothem Mg-isotope time-series data from different climate belts

NASA Astrophysics Data System (ADS)

Riechelmann, S.; Buhl, D.; Richter, D. K.; Schröder-Ritzrau, A.; Riechelmann, D. F. C.; Niedermayr, A.; Vonhof, H. B.; Wassenburg, J.; Immenhauser, A.

2012-04-01

Speleothem Mg-isotope time-series data from different climate belts Sylvia Riechelmann (1), Dieter Buhl(1), Detlev K. Richter (1), Andrea Schröder-Ritzrau (2), Dana F.C. Riechelmann (3), Andrea Niedermayr (1), Hubert B. Vonhof (4) , Jasper Wassenburg (1), Adrian Immenhauser (1) (1) Ruhr-University Bochum, Institute for Geology, Mineralogy and Geophysics, Universitätsstraße 150, D-44801 Bochum, Germany (2) Heidelberg Academy of Sciences, Im Neuenheimer Feld 229, D-69120 Heidelberg, Germany (3) Johannes Gutenberg-University Mainz, Institute of Geography, Johann-Joachim-Becher-Weg 21, D-55128 Mainz, Germany (4) Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands The Magnesium isotope proxy in Earth surface research is still underexplored. Recently, field and laboratory experiments have shed light on the complex suite of processes affecting Mg isotope fractionation in continental weathering systems. Magnesium-isotope fractionation in speleothems depends on a series of factors including biogenic activity and composition of soils, mineralogy of hostrock, changes in silicate versus carbonate weathering ratios, water residence time in the soil and hostrock and disequilibrium factors such as the precipitation rate of calcite in speleothems. Furthermore, the silicate (here mainly Mg-bearing clays) versus carbonate weathering ratio depends on air temperature and rainfall amount, also influencing the soil biogenic activity. It must be emphasized that carbonate weathering is generally dominant, but under increasingly warm and more arid climate conditions, silicate weathering rates increase and release 26Mg-enriched isotopes to the soil water. Furthermore, as shown in laboratory experiments, increasing calcite precipitation rates lead to elevated delta26Mg ratios and vice versa. Here, data from six stalagmite time-series Mg-isotope records (Thermo Fisher Scientific Neptune MC-ICP-MS) are shown. Stalagmites from caves in Morocco, Germany and Peru are presented. The lowest mean Mg-isotope compositions are found in two Pleistocene Moroccan stalagmites (delta26Mg: -4.26 ± 0.07‰ and -4.17 ± 0.15‰). The cyclical shifts in both stalagmites are best explained by periods of increasing and decreasing aridity. In contrast, Holocene Peruvian stalagmites (0 to 14 ka) show a high mean delta26Mg-value of -3.96 ± 0.04‰ and a very low level of variability in time. This is probably due to the equatorial climate lacking significant variations in temperature and/or rainfall amount. Changes in precipitation rate show effects in stalagmites from western Germany and Peru resulting in a small variability exceeding the error of the delta26Mg-values. Stalagmites from Western Germany (BU 4 mean delta26Mg: -4.20 ± 0.10‰; AH-1 mean delta26Mg: -4.01 ± 0.07‰) are, in terms of the factors that control isotope fractionation, complex. This is because factors such as precipitation rate, changes in silicate versus carbonate weathering ratios, air temperature and rainfall amount interfere in a highly complicated manner.

Teaching Science in Art: Technical Examination of 17th-Century Dutch Painting as Interdisciplinary Coursework for Science Majors and Nonmajors

ERIC Educational Resources Information Center

Uffelman, Erich S.

2007-01-01

Two linked courses examining conservation science and art history of 17th-century Dutch painting are described. The two courses have been taught on campus and, most recently, as study-abroad courses in collaboration with the Center for European Studies, Universiteit Maastricht, The Netherlands. The highly interdisciplinary courses are intense, yet…

Engineering Skills Education: The Bachelor of Engineering Programme of the "Vrije Universiteit Brussel" as a Case Study

ERIC Educational Resources Information Center

Van Biesen, Leo Pierre; Rahier, Hubert; Vanherzeele, Herman; Willem, Rudolph; Hubin, Annick; Veretennicoff, Irina; Deblauwe, Nico; Ponet, Mireille

2009-01-01

The Bologna process has triggered an important change in the course outline towards a sustainable, transparent and quality-driven European education system. In Belgium, engineering education had to be completely revised. The transformation of the former system, leading to the degree of academic engineer after five years of study, into the typical…

Bicycle use and safety in Paris, Boston, and Amsterdam

DOT National Transportation Integrated Search

1998-01-01

This article examines bicycle use and safety behavior in Paris, Boston, and Amsterdam. Population-adjusted bicycle and passenger car death rates in France, the United States, and The Netherlands provide context for understanding bicycle use and safet...

Modern Empirical Statistical Spectral Analysis.

DTIC Science & Technology

1980-05-01

716-723. Akaike, H. (1977). On entropy maximization principle, Applications of Statistics, P.R. Krishnaiah , ed., North-Holland, Amsterdam, 27-41...by P. Krishnaiah , North Holland: Amsterdam, 283-295. Parzen, E. (1979). Forecasting and whitening filter estimation, TIMS Studies in the Management

EDITORIAL: Roberts Prize for the best paper published in 2012 Roberts Prize for the best paper published in 2012

NASA Astrophysics Data System (ADS)

Cherry, Simon; Ruffle, Jon

2013-08-01

The publishers of Physics in Medicine and Biology (PMB), IOP Publishing, in association with the journal owners, the Institute of Physics and Engineering in Medicine (IPEM), jointly award the Roberts prize for the best paper published in PMB during the previous year. The procedure for deciding the winner is a two-stage process. First, a shortlist of contenders is drawn up based on those papers that had the best referees' quality assessments, with a further quality check and endorsement by the Editorial Board. The papers on the shortlist are then reviewed by a specially convened IPEM committee consisting of members with fellow status. This committee reads the shortlisted papers and selects the winner. We have much pleasure in advising readers that the Roberts Prize for the best paper published in 2012 is awarded to Michel Defrise, Ahmadreza Rezaei and Johan Nuyts from the Vrije Universiteit Brussels and the Katholieke Universiteit Leuven, Belgium for their breakthrough paper that describes how the information needed for attenuation correction in PET imaging can be extracted, to within a constant, from time-of-flight emission data: Time-of-flight PET data determine the attenuation sinogram up to a constant 2012 Phys. Med. Biol. 57 885 Michel Defrise1, Ahmadreza Rezaei2 and Johan Nuyts2 1Department of Nuclear Medicine, Vrije Universiteit Brussel, B-1090 Brussels, Belgium 2Department of Nuclear Medicine, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium This paper represents an important and timely contribution to the literature as time-of-flight PET scanners are now offered by several manufacturers. In hybrid PET/CT scanners, the PET attenuation correction, necessary for quantitative reconstruction of the tracer distribution, can be derived directly from the CT data. Sometimes, however, the PET and CT scans may be poorly aligned due to patient motion and other approaches are needed. In addition, hybrid PET/MRI scanners also, have been developed recently, and in these scanners attenuation correction of the PET data is a particularly difficult challenge as there is no direct relationship between MR signal intensity and tissue attenuation for 511 keV photons. This paper offers a possible path forwards for attenuation correction in these circumstances by exploiting consistency conditions in tandem with time-of-flight information and proves under these circumstances that the data for PET attenuation correction can be determined to within a constant. Our congratulations go to these authors. Of course all of the shortlisted papers were of an extremely high standard, and merit recognition by the community. They are listed below in alphabetical order. We also would like to thank the PMB Editorial Board and the IPEM Committee members for their hard work in assessing the papers. Simon R Cherry Editor-in-Chief Jon Ruffle Publisher References Buhr H, Büermann L, Gerlach M, Krumrey M and Rabus H 2012 Measurement of the mass energy-absorption coefficient of air for x-rays in the range from 3 keV to 60 keV Phys. Med. Biol. 57 8231 Chen W, Unkelbach J, Trofimov A, Madden T, Kooy H, Bortfeld T and Craft D 2012 Including robustness in multi-criteria optimization for intensity modulated proton therapy Phys. Med. Biol. 57 591 Clasie B M, Sharp G C, Seco J, Flanz J B and Kooy H M 2012 Numerical solutions of the gamma index in two and three dimensions Phys. Med. Biol. 57 6981 Connell T, Alexander A, Evans M and Seuntjens J 2012 An experimental feasibility study on the use of scattering foil free beams for modulated electron radiotherapy Phys. Med. Biol. 57 3259 Defrise M, Rezaei A and Nuyts J 2012 Time-of-flight PET data determine the attenuation sinogram up to a constant Phys. Med. Biol. 57 885 Dowdell S J, Clasie B, Depauw N, Metcalfe P, Rosenfeld A B, Kooy H M, Flanz J B and Paganetti H 2012 Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy Phys. Med. Biol. 57 2829 Scott A J D, Kumar S, Nahum A E and Fenwick J D 2012 Characterizing the influence of detector density on dosimeter response in non-equilibrium small photon fields Phys. Med. Biol. 57 4461 Stam M K, Crijns S P M, Zonnenberg B A, Barendrecht M M, van Vulpen M, Lagendijk J J W and Raaymakers B W 2012 Navigators for motion detection during real-time MRI-guided radiotherapy Phys. Med. Biol. 57 6797 Xia T, Alessio A M, De Man B, Manjeshwar R, Asma E and Kinahan P E 2012 Ultra-low dose CT attenuation correction for PET/CT Phys. Med. Biol. 57 309 Yamaguchi M et al 2012 Beam range estimation by measuring bremsstrahlung Phys. Med. Biol. 57 2843 For more information on this article, see medicalphysicsweb.org

Quality of Care for Patients with Type 2 Diabetes Mellitus in the Netherlands and the United States: A Comparison of Two Quality Improvement Programs

PubMed Central

Valk, Gerlof D; Renders, Carry M; Kriegsman, Didi MW; Newton, Katherine M; Twisk, Jos WR; van Eijk, Jacques ThM; van der Wal, Gerrit; Wagner, Edward H

2004-01-01

Objective To assess differences in diabetes care and patient outcomes by comparing two multifaceted quality improvement programs in two different countries, and to increase knowledge of effective elements of such programs. Study Setting Primary care in the ExtraMural Clinic (EMC) of the Department of General Practice of the Vrije Universiteit in Amsterdam, the Netherlands, and the Group Health Cooperative (GHC), a group-model health maintenance organization (HMO) in western Washington State in the United States. Data were collected from 1992 to 1997. Study Design In this observational study two diabetes cohorts in which a quality improvement program was implemented were compared. Both programs included a medical record system, clinical practice guidelines, physician educational meetings, audit, and feedback. Only the Dutch program (EMC) included guidelines on the structure of diabetes care and a recall system. Only the GHC program included educational outreach visits, formation of multidisciplinary teams, and patient self-management support. Data Collection Included were 379 EMC patients, and 2,119 GHC patients with type 2 diabetes mellitus. Main process outcomes were: annual number of diabetes visits, and number of HbA1c and blood lipid measurements. Main patient outcomes were HbA1c and blood lipid levels. Multilevel analysis was used to adjust for dependency between repeated observations within one patient and for clustering of patients within general practices. Principal Findings In the EMC process outcomes and glycemic control improved more than at GHC, however, GHC had better baseline measures. There were no differences between programs on blood lipid control. During follow-up, intensification of pharmacotherapy was noted at both sites. Differences noted between programs were in line with differences in diabetes guidelines. Conclusions Following implementation of guidelines and organizational improvement efforts, change occurred primarily in the process outcomes, rather than in the patient outcomes. Although much effort was put into improving process and patient outcomes, both complex programs still showed only moderate effects. PMID:15230924

Laser Integration on Silicon Photonic Circuits Through Transfer Printing

DTIC Science & Technology

2017-03-10

AFRL-AFOSR-UK-TR-2017-0019 Laser integration on silicon photonic circuits through transfer printing Gunther Roelkens UNIVERSITEIT GENT VZW Final...TYPE Final 3. DATES COVERED (From - To) 15 Sep 2015 to 14 Sep 2016 4. TITLE AND SUBTITLE Laser integration on silicon photonic circuits through...parallel integration of III-V lasers on silicon photonic integrated circuits. The report discusses the technological process that has been developed as

Composition of precipitation in remote areas of the world

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galloway, J.N.; Likens, G.E.; Keene, W.C.

1982-10-20

The Global Precipitation Chemistry Project collects precipitation by event to determine composition and processes controlling it in five remote areas. Compositions (excluding seasalt) at St. Georges, Bermuda, were primarily controlled by anthropogenic processes; compositions and acidities at San Carlos, Venezuela, Katherine, Australia, Poker, Flat, Alaska, and Amsterdam Island were controlled by unknown mixtures of natural or anthropogenic processes. Precipitation was acidic; average volume-weighted pH values were 4.8 for Bermuda; 5.0, Alaska; 4.9, Amsterdam Island; 4.8, Australia; 4.8, Venezuela. Acidities at Bermuda and Alaska were from long-range transport of sulfate aerosol; at Venezuela, Australia, and Amsterdam Island, from mixtures of weakmore » organic and strong mineral acids, primarily H/sub 2/SO/sub 4/. Relative proportions of weak to strong acids were largest at Venezuela and lowest at Amsterdam Island. Weak and strong acids were from mixtures of natural and anthropogenic processes. Once contributions from human activities were removed, the lower limit of natural contributions was probably > or =pH 5.« less

[The entrance to the guild chamber of the Amsterdam Guild of Surgeons].

PubMed

Ottenhof, Anne; IJpma, Frank F; van Gulik, Thomas M

2016-01-01

In the 17th and 18th centuries the entrance to the guild chamber of the Amsterdam Guild of Surgeons was located in the right corner-tower of the Waag on the Nieuwmarkt in Amsterdam. The surgeons entered their guild chamber through this door for guild meetings or to take surgical exams. The entrance also gave access to the anatomy theatre, the 'Theatrum Anatomicum', where anatomical dissections - anatomy lessons - took place. There was a bust of Hippocrates in the facade above the door, and the inscription 'Theatrum Anatomicum'. The series of 'anatomy lessons' reminds us of the famous paintings that were commissioned by the Surgeons' Guild. At the beginning of the 17th century, a skeleton was painted on the door in the gateway, and this marked the entrance to the Surgeons' Guild for almost 200 years. We examined, from a historical perspective, how the gateway to the guild chamber of the Amsterdam Guild of Surgeons was transformed over time.

A century of Dutch neurology.

PubMed

Koehler, P J; Bruyn, G W; Moffie, D

1998-12-01

The Netherlands Society of Neurology evolved from the Society of Psychiatry founded in 1871. The name was changed into Netherlands Society of Psychiatry and Neurology (NSPN) in 1897. In the same year, the word neurology was also added to the name of the journal. The Society steadily blossomed, but in 1909 the first signs of dissatisfaction occurred: the Amsterdam Neurologists Society was founded. A few split-offs would follow. The number of members of the NSPN increased from 205 in 1920 to 585 in 1960. In the early 1960s, the Society was reorganised and would consist of two sections, one for psychiatry and one for neurology. However, this would not last, as a full separation was established in 1974. For several reasons, the name of the journal was changed four times until it assumed its present name in 1974. The 100th volume of CNN was not published, as expected. in 1996, but in 1998, because of two skipped publication years, one during WWII and another in the 1970s. During the last decades of the nineteenth century, teaching of neurology was mostly given within the frame of psychiatry, following the German tradition of 'brainpsychiatry' (organic or biologic psychiatry). The first official chair of psychiatry was founded at Utrecht, 1893 (Winkler). In Amsterdam, private teachers such as Delprat taught 'electro-therapy and nervous diseases' since the 1880s. The first extraordinary chair of neurology and electrotherapy was founded for his successor, Wertheim Salomonson in 1899. The first university clinic for psychiatry and neurology started at the Amsterdam Municipal University, when Winkler became professor of psychiatry and neurology in Amsterdam in 1896. Around the turn of the century, chairs of psychiatry and neurology were also founded in Groningen and Leiden. Separate chairs for neurology and psychiatry appeared in Amsterdam in 1923 and in Utrecht in 1936. Following an initiative of Brouwer, the first neurological university clinic opened its doors in Amsterdam in 1929. In the 20th century, a number specialised peripheral neurological clinics and epilepsy institutes were founded. In 1909, the the Central Institute for Brain Research was established in Amsterdam.

The Second Year Course in Inorganic Chemistry at the Free University of Amsterdam.

ERIC Educational Resources Information Center

de Bolster, M. W. G.

1979-01-01

An inorganic chemistry course at the Free University of Amsterdam is part of an integrated program involving practical work and theoretical study for chemistry students. Twelve experiments are required and 11 are performed by students in groups of fours. (Author/SA)

[AERA. Dream machines and computing practices at the Mathematical Center].

PubMed

Alberts, Gerard; De Beer, Huub T

2008-01-01

Dream machines may be just as effective as the ones materialised. Their symbolic thrust can be quite powerful. The Amsterdam 'Mathematisch Centrum' (Mathematical Center), founded February 11, 1946, created a Computing Department in an effort to realise its goal of serving society. When Aad van Wijngaarden was appointed as head of the Computing Department, however, he claimed space for scientific research and computer construction, next to computing as a service. Still, the computing service following the five stage style of Hartree's numerical analysis remained a dominant characteristic of the work of the Computing Department. The high level of ambition held by Aad van Wijngaarden lead to ever renewed projections of big automatic computers, symbolised by the never-built AERA. Even a machine that was actually constructed, the ARRA which followed A.D. Booth's design of the ARC, never made it into real operation. It did serve Van Wijngaarden to bluff his way into the computer age by midsummer 1952. Not until January 1954 did the computing department have a working stored program computer, which for reasons of policy went under the same name: ARRA. After just one other machine, the ARMAC, had been produced, a separate company, Electrologica, was set up for the manufacture of computers, which produced the rather successful X1 computer. The combination of ambition and absence of a working machine lead to a high level of work on programming, way beyond the usual ideas of libraries of subroutines. Edsger W. Dijkstra in particular led the way to an emphasis on the duties of the programmer within the pattern of numerical analysis. Programs generating programs, known elsewhere as autocoding systems, were at the 'Mathematisch Centrum' called 'superprograms'. Practical examples were usually called a 'complex', in Dutch, where in English one might say 'system'. Historically, this is where software begins. Dekker's matrix complex, Dijkstra's interrupt system, Dijkstra and Zonneveld's ALGOL compiler--which for housekeeping contained 'the complex'--were actual examples of such super programs. In 1960 this compiler gave the Mathematical Center a leading edge in the early development of software.

The Competitive Position of Hub Airports in the Transatlantic Market

NASA Technical Reports Server (NTRS)

Burghouwt, Guillaume; Veldhuis, Jan

2006-01-01

This article puts forward the argument that the measurement of connectivity in hub-and-spoke networks has to take into account the quality and quantity of both direct and indirect connections. The NETSCAN model, which has been applied in this study, quantifies indirect connectivity and scales it into a theoretical direct connection. NETSCAN allows researchers, airports, airlines, alliances and airport regions to analyse their competitive position in an integrated way. Using NETSCAN, the authors analysed the developments on the market between northwest Europe and the United States (US) between May 2003 and May 2005. One of the most striking developments has certainly been the impact of the Air France-KLM merger and the effects of the integration of KLM and Northwest into the SkyTeam alliance on the connectivity of Amsterdam Schiphol. Direct as well as indirect connectivity (via European and North American hubs) from Amsterdam to the US increased substantially. The main reason for this increase is the integration of the former Wings and SkyTeam networks via the respective hub airports. Moreover, the extended SkyTeam alliance raised frequencies between Amsterdam and the SkyTeam hubs (Atlanta, Houston, for example), opened new routes (Cincinnati) and boosted the network between Amsterdam and France. As a result of the new routes and frequencies, Amsterdam took over Heathrow s position as the third best-connected northwest European airport to the US.

Short term effects of air pollution on emergency hospital admissions for respiratory disease: results of the APHEA project in two major cities in The Netherlands, 1977-89.

PubMed Central

Schouten, J P; Vonk, J M; de Graaf, A

1996-01-01

STUDY OBJECTIVE: To assess the short term relationship between air pollution and the daily number of emergency hospital admissions for respiratory disease. DESIGN: Data were analysed using autoregressive Poisson regression allowing for overdispersion and controlling for possible confounding factors such as seasonal and other chronological variables, meteorological factors, and influenza epidemics. SETTING: The two major cities in The Netherlands-Amsterdam (694,700 inhabitants) and Rotterdam (576,200 inhabitants). PARTICIPANTS AND MEASUREMENTS: Emergency hospital admissions for respiratory diseases, registered on a daily basis by the National Medical Registration, for the period 1977-89 were used. ICD-9 codes included were: respiratory (460-519), chronic obstructive pulmonary disease (490-492, 494, 496), and asthma (493). The mean (range) of the total daily number of admissions for these three classifications were as follows: 6.70 (0-23), 1.74 (0-9) and 1.13 (0-7) respectively in Amsterdam and 4.79 (0-19), 1.57 (0-9), and 0.53 (0-5) in Rotterdam. Air pollution measurements were provided by the National Institute of Public Health and Environmental Protection. In The Netherlands, air pollution is at a low to moderate ("summer type") or a low ("winter type") level. The levels in Amsterdam and Rotterdam did not differ much for the "summer type". For 1977-89 the mean (range) values of ozone (O3), the "summer type" pollutant (O3-8 h), were 86 (0-252) micrograms/m3 in Amsterdam and 82 (0-286) micrograms/m3 in Rotterdam. The mean (range) of the values "winter type", pollutant, sulphur dioxide (SO2-24 h), were 38 (0-381) micrograms/m3 in Amsterdam and 50 (1-379) micrograms/m3 in Rotterdam. For black smoke (BS-24 h), values were 14 (1-84) micrograms/m3 and 28 (1-144) micrograms/m3 respectively (1986-89). MAIN RESULTS: Ozone had a non-significant positive effect on the number of respiratory emergency admissions in summer in people aged > or = 65 years (relative risk for a 100 micrograms/m3 increase in O3-8 h of 1.127 (0.983, 1.292) in Amsterdam and a significant positive effect of 1.344 (1.097, 1.647) in 1977-81 in Rotterdam). Sulphur dioxide did not show any clear effects; in Amsterdam a significant negative effect was even found. The same was true for nitrogen dioxide in Amsterdam; in Rotterdam, however, nitrogen dioxide showed non-significant positive effects (RR 0.965, 1.342). Black smoke did not show any clear effects in Amsterdam; in Rotterdam it was positively but not significantly related to the number of admissions. CONCLUSIONS: The results show that the relation between short term air pollution and emergency hospital admissions is not always consistent at these rather low levels of daily hospital admissions and of air pollution. PMID:8758220

Newspaper Readership Habits in the Black Community.

ERIC Educational Resources Information Center

Gibbons, R. Arnold

This is a report of a survey conducted to determine newspaper readership habits of persons living within the circulation of the "Amsterdam News," a black weekly published in New York City. The survey was conducted with the purpose of increasing advertising revenues and assisting the management of the "Amsterdam News" with…

Conference: Three Decades of Numerical Linear Algebra at Berkeley

DTIC Science & Technology

1993-04-30

copies, to ONR as, requested. "j;r 8y......... ....-... AV 2 Ti;tles.txt JTTLAA E TCAL ISSUE DEDICATED TO PARLETT AND KAH.’N AUTHORS TITLE (1) De= el ...and Total Least Squares Ricardo D. Fierro and James R. Bunch Department of Mathematics University of California, San Diego La Jolla, CA 92093...Electrical En $ineering, Katholieke Universiteit Leuven, 3001 Heterlec, Belgium. HAESUN PARK Computer Science Department, University of Minesoa

MAGMA: A Liquid Software Approach to Fault Tolerance, Computer Network Security, and Survivable Networking

DTIC Science & Technology

2001-12-01

and Lieutenant Namik Kaplan , Turkish Navy. Maj Tiefert’s thesis, “Modeling Control Channel Dynamics of SAAM using NS Network Simulation”, helped lay...DEC99] Deconinck , Dr. ir. Geert, Fault Tolerant Systems, ESAT / Division ACCA , Katholieke Universiteit Leuven, October 1999. [FRE00] Freed...Systems”, Addison-Wesley, 1989. [KAP99] Kaplan , Namik, “Prototyping of an Active and Lightweight Router,” March 1999 [KAT99] Kati, Effraim

[The SGO Health Research Promotion Program. XIII. Evaluation of the section 'Addiction Research'].

PubMed

van Rees-Wortelboer, M M

1999-01-02

As a part of the SGO Health Research Promotion Programme a research programme on addiction research was realized. Aim of the programme was to strengthen and concentrate the Dutch research into addiction. Within the Amsterdam Institute for Addiction Research (AIAR), a structural collaboration between the Jellinek Treatment Centre for Addiction, the University of Amsterdam and the Academic Hospital of the University of Amsterdam, strategic research programmes were developed on the borderland of addiction and psychiatry, notably 'Clinical epidemiology addiction' and 'Developmental disorders, addiction and psychotraumas'. The institution of a co-ordinating platform of research groups conducting socio-epidemiological addiction research improved the co-ordination of research lines in this field.

Student Employment among Descendants of Turkish Migrants in Amsterdam and Strasbourg

ERIC Educational Resources Information Center

Keskiner, Elif

2017-01-01

This article compares and contrasts the nature of student employment experience in Amsterdam and Strasbourg among descendants of Turkish migrants. The analysis relies on in-depth qualitative interviews revealing the experience of student employment and the impact of working while studying on the educational careers and future labour market…

Slow Epidemic of Lymphogranuloma Venereum L2b Strain

PubMed Central

Spaargaren, Joke; Schachter, Julius; Moncada, Jeanne; de Vries, Henry J.C.; Fennema, Han S.A.; Peña, A. Salvador; Coutinho, Roel A.

2005-01-01

We traced the Chlamydia trachomatis L2b variant in Amsterdam and San Francisco. All recent lymphogranuloma venereum cases in Amsterdam were caused by the L2b variant. This variant was also present in the 1980s in San Francisco. Thus, the current "outbreak" is most likely a slowly evolving epidemic. PMID:16318741

Reevaluation of the Amsterdam Inventory for Auditory Disability and Handicap Using Item Response Theory

ERIC Educational Resources Information Center

Hospers, J. Mirjam Boeschen; Smits, Niels; Smits, Cas; Stam, Mariska; Terwee, Caroline B.; Kramer, Sophia E.

2016-01-01

Purpose: We reevaluated the psychometric properties of the Amsterdam Inventory for Auditory Disability and Handicap (AIADH; Kramer, Kapteyn, Festen, & Tobi, 1995) using item response theory. Item response theory describes item functioning along an ability continuum. Method: Cross-sectional data from 2,352 adults with and without hearing…

Going Dutch: Higher Education in the Netherlands

ERIC Educational Resources Information Center

Law, David

2016-01-01

This article outlines some of the policy issues currently faced by research-based universities in the Netherlands. The focus is on four leading universities (University of Amsterdam: UvA; Free University of Amsterdam: VU; Leiden University; and Delft University of Technology: TUD). The author visited these institutions as part of a Study Tour…

Composition of precipitation in remote areas of the world

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galloway, J.N.; Likens, G.E.; Keene, W.C.

1982-10-20

The Global Precipitation Chemistry Project collects precipitation by event to determine composition and processes controlling it in five remote areas. Compositions (excluding sea-salt) at St. Georges, Bermuda, were primarily controlled by anthropogenic processes; composition and acidities at San Carlos, Venezuela, Katherine, Australia, Poker Flat, Alaska, and Amsterdam Island were controlled by unknown mixtures of natural or anthropogenic processes. Precipitation was acidic; average volume-weighted pH values were 4.8 for Bermuda; 5.0, Alaska; 4.9, Amsterdam Island; 4.8, Australia; 4.8, Venezuela. Acidities at Bermuda and Alaska were from long-range transport of sulfate aerosol; at Venezuela, Australia, and Amsterdam Island, from mixtures of weakmore » organic and strong mineral acids, primarily H/sub 2/SO/sub 4/. Relative proportions of weak to strong acids were largest at Venezuela and lowest at Amsterdam Island. Weak and strong acids were from mixtures of natural and anthropogenic processes. Once contributions from human activities were removed, the lower limit of natural contributions was probably greater than or equal to pH 5.« less

Reduction of zinc emissions from buildings; the policy of Amsterdam.

PubMed

Gouman, E

2004-01-01

In Amsterdam zinc coming from the roofs and gutters of the buildings accounts for about 50% of the zinc emissions into the surface water (i.e. canals and rivers). This causes water and sediment pollution. Dumping strongly polluted sediment costs ten times more then dumping less polluted mud. Therefore the City of Amsterdam has developed a policy for reducing the zinc emissions from buildings based on the current environmental legislation and the current national targets for surface water quality. Zinc roofs on new and renovated buildings are not permitted. Run off water from zinc roofs of existing buildings is allowed to contain a maximum of 200 microg/l zinc. For the zinc gutters of houses, Amsterdam will promote measures to reduce zinc emissions. To investigate the feasibility of measures, research has been carried out on the zinc emissions of gutters and the effect of covering gutters with an impermeable foil. This research shows clearly that covering zinc gutters with EPDM foil reduces the zinc emissions by 90% from 8.5 to 0.88 gram per square metre per year including the atmospheric deposition.

University-Industry Cooperation: Preferences and Interests and Small- and Medium-Sized Firms in the Amsterdam Region, The Netherlands.

ERIC Educational Resources Information Center

Schnek, Peter; Tordoir, Pieter

1984-01-01

Results of a survey of Amsterdam-area industries concerning university-industry cooperation and technology transfer are reported. Industries prefer R&D and consulting and indicate great interest in what the universities can offer in such relationships. However, they feel universities should initiate contact. Further cooperative strategies are…

Amsterdam in Bloom: An Inner City School Garden Project

ERIC Educational Resources Information Center

McFadyen, Elen

2004-01-01

In this article, the author describes the educational potential of a garden project. When the opportunity to visit a school in Amsterdam arose as part of her primary science PGCE course, the author jumped at the chance to experience science learning in another country. The majority of teaching that took place was topic-based, and science was…

Laboratory spectroscopy of Mars Analogue materials and latest field results from Iceland and Eifel

NASA Astrophysics Data System (ADS)

Offringa, Marloes; Foing, Bernard H.

2016-07-01

We have established a collection of samples, and measured them in the laboratory towards a spectrometric database that could be used as a reference for future orbital or in situ measurements. We are using systematically for all samples UV-VIS and NIR reflectance spectrometers, and sporadically a Fourier Transform Infrared (FTIR) spectrometer, an X-Ray Fluorescence (XRF) spectrometer and a Raman laser spectrometer on control samples. We also used a documented set of Moon-Mars relevant minerals curated at VU Amsterdam, as well as samples retrieved from Mars analogue campaigns in Utah (Foing et al., 2011, 2016), Iceland (Mid-Atlantic ridge spreading and magma-ice interaction), La Réunion hot spot volcano and Eifel volcanic region (mixed hotspot and melt-ascent through crust fractures) from recent campaigns in 2015 and 2016.. We discuss samples spectral diagnostics of volcanic processes and hydrous alterations that can inform recent or upcoming measurements from Mars orbit or in situ rovers. Acknowledgements: we thank Dominic Doyle for ESTEC optical lab support, Euan Monaghan (Leiden U) for FTIR measurement support, Wim van Westrenen for access to VU samples, Oscar Kamps (Utrecht U), Aidan Cowley (EAC) and Matthias Sperl (DLR) for support discussions

A Study of Sociolinguistic Variation in a Small Community: Puerto Rican Spanish in Amsterdam, New York

ERIC Educational Resources Information Center

Mumin, Zahir

2017-01-01

The objective of the current study is to contribute to the larger body of sociophonetic variation research by describing and analyzing Spanish as spoken in a small Puerto Rican community in the US. First, I describe phonological and morphosyntactic features of Spanish as used by four different groups of Puerto Rican informants in Amsterdam, New…

Amsterdam's Airport Library Serves Passengers in 30 Languages

ERIC Educational Resources Information Center

Dempsey, Kathy

2011-01-01

In the summer of 2010, Schiphol Airport in Amsterdam started offering the world's first library in an airport. This article describes Airport Library which is no ordinary library. It holds more than 1,200 items, but it lends nothing. It operates 24/7, yet it's only staffed by volunteers for 2 or 3 hours a day. It offers just nine public-access…

Mutualism, resource competition and opposing movements among Turkish organizations in Amsterdam and Berlin, 1965-2000.

PubMed

Vermeulen, Floris

2013-09-01

This article seeks to understand environmental effects on associational interdependencies, be they competitive or collaborative, in a polarized organizational population. To do so, it builds on the density-dependent model and the ecology of ideologies. Especially interested in the effect of context on density-dependent processes, I compare different Turkish ideological movements in Amsterdam and Berlin. Amsterdam represents an open and supportive environment for such movements, whereas Berlin constitutes a more closed and hostile one. By analysing the founding and disbanding rates of Turkish immigrant organizations in Amsterdam and Berlin during the period 1965-2000, the article demonstrates how the increasing density of Turkish ideologies has affected interdependencies in two main ways: by heightening competition, particularly between ideologically similar organizations, and by increasing counter activities between opposing movements. It also shows that the influence of context is limited. An open environment does not significantly influence the vitality rates of ideologies or further collaboration among or between them. On the contrary, it seemingly increases competition and fragmentation because more resources and opportunities are available. More signs of collaboration and mutualism are found in Berlin's closed environment. © London School of Economics and Political Science 2013.

Vascular Cognitive Impairment in a Memory Clinic Population: Rationale and Design of the "Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment" (TRACE-VCI) Study.

PubMed

Boomsma, Jooske Marije Funke; Exalto, Lieza Geertje; Barkhof, Frederik; van den Berg, Esther; de Bresser, Jeroen; Heinen, Rutger; Koek, Huiberdina Lena; Prins, Niels Daniël; Scheltens, Philip; Weinstein, Henry Chanoch; van der Flier, Wiesje Maria; Biessels, Geert Jan

2017-04-19

Vascular Cognitive Impairment (VCI) refers to cognitive dysfunction due to vascular brain injury, as a single cause or in combination with other, often neurodegenerative, etiologies. VCI is a broad construct that captures a heterogeneous patient population both in terms of cognitive and noncognitive symptoms and in terms of etiology and prognosis. This provides a challenge when applying this construct in clinical practice. This paper presents the rationale and design of the TRACE-VCI study, which investigates the clinical features and prognosis of VCI in a memory clinic setting. The TRACE-VCI project is an observational, prospective cohort study of 861 consecutive memory clinic patients with possible VCI. Between 2009 and 2013, patients were recruited through the Amsterdam Dementia Cohort of the VU University Medical Centre (VUMC) (N=665) and the outpatient memory clinic and VCI cohort of the University Medical Centre Utrecht (UMCU) (N=196). We included all patients attending the clinics with magnetic resonance imaging (MRI) evidence of vascular brain injury. Patients with a primary etiology other than vascular brain injury or neurodegeneration were excluded. Patients underwent an extensive 1-day memory clinic evaluation including an interview, physical and neurological examination, assessment of biomarkers (including those for Alzheimer-type pathologies), extensive neuropsychological testing, and an MRI scan of the brain. For prognostic analyses, the composite primary outcome measure was defined as accelerated cognitive decline (change of clinical dementia rating ≥1 or institutionalization) or (recurrent) major vascular events or death over the course of 2 years. The mean age at baseline was 67.7 (SD 8.5) years and 46.3% of patients (399/861) were female. At baseline, the median Clinical Dementia Rating was 0.5 (interquartile range [IQR] 0.5-1.0) and the median Mini-Mental State Examination score was 25 (IQR 22-28). The clinical diagnosis at baseline was dementia in 52.4% of patients (451/861), mild cognitive impairment in 24.6% (212/861), and no objective cognitive impairment in the remaining 23.0% (198/861). The TRACE-VCI study represents a large cohort of well-characterized patients with VCI in a memory clinic setting. Data processing and collection for follow-up are currently being completed. The TRACE-VCI study will provide insight into the clinical features of memory clinic patients that meet VCI criteria and establish key prognostic factors for further cognitive decline and (recurrent) major vascular events. ©Jooske Marije Funke Boomsma, Lieza Geertje Exalto, Frederik Barkhof, Esther van den Berg, Jeroen de Bresser, Rutger Heinen, Huiberdina Lena Koek, Niels Daniël Prins, Philip Scheltens, Henry Chanoch Weinstein, Wiesje Maria van der Flier, Geert Jan Biessels. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 19.04.2017.

[The zoological garden of Amsterdam Natura Artis Magistra during world War II].

PubMed

Frankenhuis, Maarten Th

2009-01-01

Thanks to the wise management of its director, dr. Armand Sunier, and his team, 'Artis' survived the difficult war period without great losses of its animals and only material damage to some buildings. Artis has meant very much for the inhabitants of the city of Amsterdam during the war. In the first place for the employees and their families, that were kept for starvation and forced labour by extra rations of food and safe hiding places. But also for jewish persons in hiding, who could escape from a certain death by hiding in animal houses or other buildings in the garden. And also for hundreds of thousands people of Amsterdam who found in their zoological garden an oasis of relaxation in a town full of threat and violence.

Micromorphology in unconsolidated landslide sediments - investigating mass movement deposits at a different scale

NASA Astrophysics Data System (ADS)

Jaeger, Daniel; Menzies, John

2015-04-01

In order to reliably reconstruct a landslide event, its triggers, movements and the main factors of influence, a profound knowledge of the slide masses' inner architecture and their internal processes is of great importance. As van der Meer (1996) states, micromorphology permits a complete examination of particles, matrix and all components contained in unconsolidated sediments, as well as an insight into their internal arrangement. So far, thin sections and micromorphology are mainly used for studying marine, periglacial and glacial sediments (e.g. Maltman 1988; van der Meer 1993, Menzies 2000, van Fliet-Lanoe 2010, van der Meer & Menzies 2011). Comparatively little work has been carried out with a focus on landslides (e.g. Bertran & Texier 1999). Therefore, our work is a first attempt at investigating unconsolidated deposits of landslides in the low mountain areas of southern Germany using micromorphological tools. The objective was to observe sedimentary microstructures in order to gain an understanding of the sediments' internal movement, deformation etc. during a slide event. On the investigated landslides near Ebermannstadt (Franconian Alb), Gailnau (Frankenhöhe region) and Talheim (Swabian Alb) samples were taken from small pits or outcrops (depths between 50 cm - 300 cm below the surface) in the upper, central and lower part (foot) of the slide mass. The thin section analyses revealed several differences between the three environments and within the specific landslides themselves. Most prominently, several structures (e.g. water-escape-structures, flow-noses and rotational structures) indicate a crucial impact of water in all three slide masses. Furthermore, the thin sections showed heterogeneous compositions of different sediment materials and aggregates, presumably transported, mixed together and deformed during the slide movement. In Ebermannstadt and Talheim, several ductile and brittle deformation structures (rotational structures, marbled structures, fractures, crushed grains) were obvious in those deposits, proving a rather turbulent mass movement with pervasive pressure and stress and varying phases of deformation. In contrast, thin sections from Gailnau only provided very slight deformation structures, which lead to the assumption of a completely different and steadier type of movement with less pressure. Downslope, samples from all landslides showed accumulations of broken fragments with plasma filling out (parts of) the joints, while samples from the front areas (foot) revealed plasma-dominated, structureless, homogenized sediments with varying amounts of sand particles but with few fragments in it. This leads to the assumption of water-saturated plasma being squeezed out of the main accumulation body during its deposition, creating a flow-type movement in the foremost part of both landslides. The results significantly improved the understanding of the behavior of the landslides as several details in terms of processes and structures could be revealed. The micromorphological analyses also helped to validate presumptions gathered from geomorphological mapping and geophysical soundings. Although continuing research into the microstructure of landslide deposits is necessary, our investigations already illustrate the potential value of micromorphology in this environment. References - Bertran, P. & Texier, J.-P. (1999). Facies and microfacies of slope deposits. Catena 35: 99-121. - Maltman, A. J. (1988). The importance of shear zones in naturally deformed wet sediments. Tectonophysics 145: 163-175. - Menzies, J. (2000). Micromorphological analyses of microfabrics and microstructures, indicative of deformation processes. In: Maltman, A. J. Hubbard, B., Hambrey, M.J. (Eds.): Deformations of Glacial Materials. Geological Society, London, 245-258. - van der Meer, J. J. M. (1993). Microscopic evidence of subglacial deformation. Quaternary Science Reviews 12: 553-587. - van der Meer, J.J.M. (1996): Micromorphology. In: Menzies, J. (Ed.): Past Glacial Environments - Sediments, Forms and Techniques. Butterworth-Heinemann, Oxford, 335-356. - van der Meer, J. J. M. & Menzies, J. (2011). The micromorphology of unconsolidated sediments. Sedimentary Geology 238: 213-232. - van Fliet-Lanoe, B. (2010). Frost action. In: Stoops, G. Marcelino, V., Mees, F.: Interpretation of micromorphological features of soils and regoliths. Elsevier, Amsterdam, 81-108.

Time Series Model Identification by Estimating Information.

DTIC Science & Technology

1982-11-01

principle, Applications of Statistics, P. R. Krishnaiah , ed., North-Holland: Amsterdam, 27-41. Anderson, T. W. (1971). The Statistical Analysis of Time Series...E. (1969). Multiple Time Series Modeling, Multivariate Analysis II, edited by P. Krishnaiah , Academic Press: New York, 389-409. Parzen, E. (1981...Newton, H. J. (1980). Multiple Time Series Modeling, II Multivariate Analysis - V, edited by P. Krishnaiah , North Holland: Amsterdam, 181-197. Shibata, R

Treatment of Basal Cell Carcinoma Using a One-Stop-Shop With Reflectance Confocal Microscopy: Study Design and Protocol of a Randomized Controlled Multicenter Trial.

PubMed

Kadouch, Daniel J; Wolkerstorfer, Albert; Elshot, Yannick; Zupan-Kajcovski, Biljana; Crijns, Marianne B; Starink, Markus V; Bekkenk, Marcel W; van der Wal, Allard C; Spuls, Phyllis I; de Rie, Menno A

2015-09-10

Basal cell carcinoma (BCC) is the most common cancer diagnosed in white populations worldwide. The rising incidence of BCC is becoming a major worldwide public health problem. Therefore, there is a need for more efficient management. The aim of this research is to assess the efficacy and safety of a one-stop-shop (OSS) concept, using real-time in vivo reflectance confocal microscopy (RCM) (Vivascope 1500; Lucid Technologies, Henrietta, NY, USA) as a diagnostic tool, prior to surgical management of new primary BCCs. This is a prospective non-inferiority multi-center RCT designed to compare the "OSS concept using RCM" to current standards of care in diagnosing and treating clinically suspected BCC. Patients ≥ 18 years attending our outpatient clinic at the Department of Dermatology, Academic Medical Center, University of Amsterdam, and the Department of Dermatology, the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (Amsterdam, The Netherlands) with a clinically suspected new primary BCC lesion will be considered for enrollment using predefined inclusion and exclusion criteria, and will be randomly allocated to the experimental or control group. The main outcome parameter is the assessment of incomplete surgical excision margins on the final pathology report of confirmed BCC lesions (either by punch biopsy or RCM imaging). Other outcome measures include diagnostic accuracy (sensitivity and specificity) of RCM for diagnosing BCC and dividing between subtypes, and throughput time. Patient satisfaction data will be collected postoperatively after 3 months during routine follow-up. This research is investigator-initiated and received ethics approval. Patient recruitment started in February 2015, and we expect all study-related activities to be completed by fall 2015. This RCT is the first to examine an OSS concept using RCM for diagnosing and treating clinically suspected BCC lesions. Results of this research are expected to have applications in evidence-based practice for the increasing number of patients suffering from BCC and possibly lead to a more efficient disease management strategy. ClinicalTrials.gov: NCT02285790; https://clinicaltrial.gov/ct2/show/NCT02285790 (Archived by WebCite at http://www.webcitation.org/6b2LfDKWu).

Cannabis policies and user practices: market separation, price, potency, and accessibility in Amsterdam and San Francisco.

PubMed

Reinarman, Craig

2009-01-01

This paper explores user perceptions and practices in contrasting legal-policy milieux-Amsterdam (de facto decriminalization) and San Francisco (de jure criminalization) on four policy issues: sources of cannabis and separation of markets for it and other drugs; user perceptions of effects of price on consumption; effects of potency on consumption; and perceived risk of arrest and accessibility of cannabis. Questions on these issues were added to surveys on career use patterns amongst representative samples of experienced cannabis users using comparable methods. Most San Francisco respondents obtained cannabis through friends who knew dealers, whereas most Amsterdam respondents obtained it from regulated shops. Only one in seven Amsterdam respondents but half the San Francisco respondents could obtain other drugs from their cannabis sources. Majorities under both systems had never found cannabis "too expensive." Amsterdam respondents preferred milder cannabis whilst San Francisco respondents preferred stronger; majorities in both cities reported self-titrating with potent cannabis. Risk and fear of arrest were higher in San Francisco, but most in both cities perceived arrest as unlikely. Estimated search times were somewhat longer in San Francisco, but a majority reported being able to access it within half a day. There is substantial separation of markets in the Dutch system. Policies designed to increase cannabis prices appear unlikely to impact consumption. Decriminalization was associated with a preference for milder cannabis, but under both policy regimes most respondents self-titrated when using more potent strains. Criminalization was associated with somewhat higher risk and fear of arrest and somewhat longer search times, but these did not appear to significantly impede access for most respondents.

Annotated translation of "Nota in verband met de voorgenomen putboring nabij Amsterdam [Note concerning the intended well drilling near Amsterdam]" by J. Drabbe and W. Badon Ghijben (1889)

NASA Astrophysics Data System (ADS)

Post, Vincent E. A.

2018-06-01

The famous report by engineers Drabbe and Badon Ghijben (1889), on an intended well drilling near Amsterdam (the Netherlands), was one of the key documents that contributed to the Ghijben-Herzberg formula, which links water-table elevation to the depth of the freshwater-saltwater interface in coastal aquifers. The report has been often cited but no English translation has appeared in the literature to date. The aim of this annotated translation of the report is to provide the international scientific community with easier access than was hitherto the case, plus electronic access to the original in Dutch. A brief introduction to the report is provided, followed by a translation that follows the original text as closely as possible.

A Report of the Amsterdam Forum On the Care of the Live Kidney Donor: Data and Medical Guidelines.

PubMed

Delmonico, Francis

2005-03-27

Kidney transplant physicians and surgeons met in Amsterdam, The Netherlands, from April 1-4, 2004 for the International Forum on the Care of the Live Kidney Donor. Forum participants included over 100 experts and leaders in transplantation representing more than 40 countries from around the world, including participants from the following continents: Africa, Asia, Australia, Europe, North America, and South America.

Toughness and Matching Extension in Graphs,

DTIC Science & Technology

1986-05-01

New York, 1977. V. CHVATAL 1973a. Tough graphs and Hamiltonian circuits, Discrete Math . 5, 1973, 215- 228. 1973b. New directions in Hamiltonian...PLUMMER 1986. Matching Theory, Ann. Discrete Math ., North-Holland, Amsterdam, 1986 (to appear). M. D. PLUMMER 1980. On n-extendable graphs, Discrete ... Math . 31, 1980, 201-210. 1985. A theorem on matchings in the plane, Conference in memory of Gabriel Dirac, Ann. Discrete Math ., North-Holland, Amsterdam

Analysis of Spatial Disorientation Mishaps in the US Navy

DTIC Science & Technology

2003-02-01

optokinetic after- nystagmus (OKAN) and vestibular nystagmus . In: Baker R, Berthoz A, eds. Control of gaze by grain stem neurons, Amsterdam: Elsevier...of explaining by modeling. In: Baker R, Berthoz A, eds. Control of gaze by grain stem neurons, developments in neuroscience, Vol. 1. Amsterdam...Elsevier/North-Holland Biomedical Press, 49-58. Raphan T, Matsuo V, Cohen B. (1977) A velocity storage mechanism responsible for optokinetic nystagmus (OKN

Consumption of tobacco, alcohol and recreational drugs in university students in Belgium and the Netherlands: the role of living situation.

PubMed

Boot, Cécile R L; Rosiers, Johan F M; Meijman, Frans J; Van Hal, Guido F G

2010-01-01

Studying at university/college is associated with consumption of tobacco, alcohol and recreational drugs. This lifestyle may be associated with moving outside parental control. The aim of this study was to investigate differences between students living with their parents and students living alone or with peers regarding substance use in Belgium (Antwerp) and The Netherlands (Amsterdam). The results of two separate surveys, one in Amsterdam (8,258 students) and one in Antwerp (27,210 students) were compared. Both questionnaires contained items about consumption of tobacco, alcohol and recreational drugs, and whether students considered their consumption as a problem and relevant confounders. Students living with their parents were compared with students living alone or with peers, using multivariate logistic regression analyses, separate for Antwerp and Amsterdam. Consumption of tobacco was associated with living with peers. Similar patterns were shown for consumption of alcohol and recreational drugs. Living with peers rather than living with family or alone was a determinant of problematic substance use as well. Patterns were similar for both universities in two different countries. Students living alone or with peers in Amsterdam and Antwerp may be at risk for problems concerning their consumption of recreational drugs. These findings may have implications for targeted prevention programs.

Prayer Healing: A Case Study Research Protocol.

PubMed

Kruijthoff, Dirk J; van der Kooi, Cornelis; Glas, Gerrit; Abma, Tineke A

2017-01-01

Context • Prayer healing is a common practice in many religious communities around the world. Even in the highly secularized Dutch society, cases of prayer healing are occasionally reported in the media, often generating public attention. There is an ongoing debate regarding whether such miraculous cures do actually occur and how to interpret them. Objective • The aim of the article was to present a research protocol for the investigation of reported cases of remarkable and/or unexplained healing after prayer. Design • The research team developed a method to perform a retrospective, case-based study of prayer healing. Reported prayer healings can be investigated systematically in accordance with a step-by-step methodology. The focus is on understanding the healing by studying it from multiple perspectives, using both medical judgment and patients' narratives collected by qualitative methods Setting • The study occurred at Vrije Universiteit (VU) and VU Medical Center (Amsterdam, Netherlands) as well as the general medical practice of the first author. Participants • Potential participants could be any individuals in the Netherlands or neighboring countries who claim to have been healed through prayer. The reports of healing came from multiple sources, including the research team's medical practices and their direct vicinities, newspaper articles, prayer healers, and medical colleagues. Outcome Measures • Medical data were obtained before and after prayer. Subsequently, a member of a research team and of a medical assessment committee made a standardized judgment that evaluated whether a cure was clinically remarkable or scientifically unexplained. The participants' experiences and insider perspectives were studied, using in-depth interviews in accordance with a qualitative research methodology, to gain insight into the perceptions and explanations of the cures that were offered by participants and by the members of the medical assessment committee. The medical findings and participants' experiences were weighed and interpreted based on a transdisciplinary framework, including biopsychosocial and theological perspectives, with reference to a conceptual framework derived from Ian Barbour's typology of positions in the science-religion debate. Conclusion • A case-based, research study protocol that compares medical and experiential findings and that interprets and structures those findings with reference to Ian Barbour's conceptual model is an innovative way of gaining deeper insight into the nature of remarkable and/or unexplained cures.

Estimating Soil Moisture from Satellite Microwave Observations

NASA Technical Reports Server (NTRS)

Owe, M.; VandeGriend, A. A.; deJeu, R.; deVries, J.; Seyhan, E.

1998-01-01

Cooperative research in microwave remote sensing between the Hydrological Sciences Branch of the NASA Goddard Space Flight Center and the Earth Sciences Faculty of the Vrije Universiteit Amsterdam began with the Botswana Water and Energy Balance Experiment and has continued through a series of highly successful International Research Programs. The collaboration between these two research institutions has resulted in significant scientific achievements, most notably in the area of satellite-based microwave remote sensing of soil moisture. The Botswana Program was the first joint research initiative between these two institutions, and provided a unique data base which included historical data sets of Scanning Multifrequency Microwave Radiometer (SN4NM) data, climate information, and extensive soil moisture measurements over several large experimental sites in southeast Botswana. These data were the basis for the development of new approaches in physically-based inverse modelling of soil moisture from satellite microwave observations. Among the results from this study were quantitative estimates of vegetation transmission properties at microwave frequencies. A single polarization modelling approach which used horizontally polarized microwave observations combined with monthly composites of Normalized Difference Vegetation Index was developed, and yielded good results. After more precise field experimentation with a ground-based radiometer system, a dual-polarization approach was subsequently developed. This new approach realized significant improvements in soil moisture estimation by satellite. Results from the Botswana study were subsequently applied to a desertification monitoring study for the country of Spain within the framework of the European Community science research programs EFEDA and RESMEDES. A dual frequency approach with only microwave data was used for this application. The Microwave Polarization Difference Index (MPDI) was calculated from 37 GHz data and used to derive the one-way canopy transmissivity. Using a simple radiative transfer model, this information was combined with horizontally polarized 6.6 GHz SMMR observations to derive a 9-year time series of soil moisture for all of Spain at a one quarter degree spatial scale. Both day and night SMMR observations were used independently, in order to check the consistency of the results. A first order Fourier Transform was performed on the mean monthly soil moisture values to identify major characteristics of time series such as trend, amplitude, and phase shift.

Incidence of repeat testing and diagnoses of Chlamydia trachomatis and Neisseria gonorrhoea in swingers, homosexual and heterosexual men and women at two large Dutch STI clinics, 2006-2013.

PubMed

Dukers-Muijrers, Nicole H T M; van Rooijen, Martijn S; Hogewoning, Arjan; van Liere, Genevieve A F S; Steenbakkers, Mieke; Hoebe, Christian J P A

2017-09-01

Swingers, that is, heterosexuals who as a couple have sex with others, including group sex and bisexual behaviour, are an older-aged risk group for STIs. Here, we report on their repeat testing (reattendance) and STI yield compared with other heterosexuals and men who have sex with men (MSM, homosexual men) at two Dutch STI clinics. Swingers are routinely (since 2006, South Limburg, registration-completeness: 99%) or partially (since 2010, Amsterdam, registration-completeness: 20%) included in the clinic patient registries. Data (retrospective cohort) are analysed to assess incidence (per 100 person-years (PY)) of reattendance and STI ( Chlamydia trachomatis (CT) and/or Neisseria gonorrhoeae (NG)) and associated factors calculating HRs. In South Limburg 7714 and in Amsterdam 2070 swinger consultations were identified. Since 2010, swingers' incidence of reattendance was 48-57/100 PY. Incidence was lower in MSM (30-39/100 PY, HR 0.56; 95% CI 0.51 to 0.61, South Limburg; HR 0.88; 95% CI 0.80 to 0.96, Amsterdam), heterosexual men (8-14/100 PY, HR 0.16; 95% CI 0.15 to 0.17, South Limburg; HR 0.33; 95% CI 0.30 to 0.36, Amsterdam) and women (13-20/100 PY, HR 0.56; 95% CI 0.51 to 0.61, South Limburg; HR 0.46; 95% CI 0.42 to 0.51, Amsterdam). Swingers' STI incidence at reattendance was 11-12/100 PY. Incidence was similar in heterosexual men (14-15/100 PY; HR 1.19; 95% CI 0.90 to 1.57, South Limburg; HR 1.20; 95% CI 0.91 to 1.59, Amsterdam) and women (12-14/100 PY; HR 1.14; 95% CI 0.88 to 1.49, South Limburg; HR 0.98; 95% CI 0.74 to 1.29, Amsterdam) and higher in MSM (18-22/100 PY; HR 1.59; 95% CI 1.19 to 2.12, South Limburg; HR 1.80; 95% CI 1.36 to 2.37, Amsterdam). Risk factors for STI incidence were partner-notified (contact-tracing), symptoms and previous STI. Swingers' positivity at any clinic attendance was 3-4% for NG (ie, higher than other heterosexuals) and 6-8% for CT (ie, lower than heterosexuals overall but higher than older heterosexuals). Systematic identification reveals that swingers are part of the normal STI clinic populations. They frequently repeat test yet are likely under-recognised in clinics which not routinely ask about swinging. Given swingers' notable STI rates, usage of services is warranted, although use may be restricted, that is, to those with an STI risk factor (as did Dutch clinics). As swingers have dense sexual networks, enhancing contact-tracing may have high impact. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Time Series Model Identification by Estimating Information, Memory, and Quantiles.

DTIC Science & Technology

1983-07-01

Standards, Sect. D, 68D, 937-951. Parzen, Emanuel (1969) "Multiple time series modeling" Multivariate Analysis - II, edited by P. Krishnaiah , Academic... Krishnaiah , North Holland: Amsterdam, 283-295. Parzen, Emanuel (1979) "Forecasting and Whitening Filter Estimation" TIMS Studies in the Management...principle. Applications of Statistics, P. R. Krishnaiah , ed. North Holland: Amsterdam, 27-41. Box, G. E. P. and Jenkins, G. M. (1970) Time Series Analysis

Matching Extension and Connectivity in Graphs. 1. Introduction and Terminology,

DTIC Science & Technology

1986-01-01

minimal elementary bipartite graphs, J. Combin. Theory Ser. B 23, 1977, 127-138. 1986. Matching Theory, Ann. Discrete Math ., North-Holland, Amsterdam, 1986...to appear). M. D. PLUMMER 1980. On n-extendable graphs, Discrete Math . 31, 1980, 201-210. 1985. A theorem on matchings in the plane, Conference in...memory of Gabriel Dirac, Ann. Discrete Math ., North-Holland, Amsterdam, to appear. 1986a. Matching extension in bipartite graphs, preprint, 1986. 1986b

Some Recent Results on Graph Matching,

DTIC Science & Technology

1987-06-01

V. CHVATAL, Tough graphs and Hamiltonian circuits, Discrete Math . 5, 1973, 215-228. [El] J. EDMONDS, Paths, trees and flowers, Canad. J. Math. 17...Theory, Ann. Discrete Math . 29, North-Holland, Amsterdam, 1986. [N] D. NADDEF, Rank of maximum matchings in a graph, Math. Programming 22, 52-70. [NP...Optimization, Ann. Discrete Math . 16, North-Holland, Amsterdam, 1982, 241-260. [P1] M.D. PLUMMER, On n-extendable graphs, Discrete Math . 31, 1980, 201-210

Parallel deterioration to language processing in a bilingual speaker.

PubMed

Druks, Judit; Weekes, Brendan Stuart

2013-01-01

The convergence hypothesis [Green, D. W. (2003). The neural basis of the lexicon and the grammar in L2 acquisition: The convergence hypothesis. In R. van Hout, A. Hulk, F. Kuiken, & R. Towell (Eds.), The interface between syntax and the lexicon in second language acquisition (pp. 197-218). Amsterdam: John Benjamins] assumes that the neural substrates of language representations are shared between the languages of a bilingual speaker. One prediction of this hypothesis is that neurodegenerative disease should produce parallel deterioration to lexical and grammatical processing in bilingual aphasia. We tested this prediction with a late bilingual Hungarian (first language, L1)-English (second language, L2) speaker J.B. who had nonfluent progressive aphasia (NFPA). J.B. had acquired L2 in adolescence but was premorbidly proficient and used English as his dominant language throughout adult life. Our investigations showed comparable deterioration to lexical and grammatical knowledge in both languages during a one-year period. Parallel deterioration to language processing in a bilingual speaker with NFPA challenges the assumption that L1 and L2 rely on different brain mechanisms as assumed in some theories of bilingual language processing [Ullman, M. T. (2001). The neural basis of lexicon and grammar in first and second language: The declarative/procedural model. Bilingualism: Language and Cognition, 4(1), 105-122].

On the 2-Extendability of Planar Graphs

DTIC Science & Technology

1989-01-01

connectivity for n-extend- ability of regular graphs, 1988, submitted. [6] L. Lov~isz and M.D. Plummer, Matching Theory, Ann. Discrete Math . 29, North...Holland, Amsterdam, 1986. [7] M.D. Plummer, On n-extendable graphs, Discrete Math . 31, 1980, 201-210. [8] M.D. Plummer, A theorem on matchings in the...plane, Graph Theory in Memory of G.A. Dirac, Ann. Discrete Math . 41, North-Holland, Amsterdam, 1989, 347-354. [9] C. Thomassen, Girth in graphs, J

Data for DoD Manpower Policy Analysis

DTIC Science & Technology

2009-01-01

World War II Veterans Earn More Than Nonveterans?” Journal of Labor Economics , Vol. 12, No. 1, January 1994, pp. 74–97. ———, “Empirical Strategies in... Labor Economics ,” in Orley Ashenfelter and David Cards, eds., Handbook of Labor Economics Vol. 3a, Amsterdam, N.Y.: North-Holland, 2001. Antel, John...Microdata in Labor Economics Research,” in Handbook of Labor Economics , 1st ed., Orley Ashenfelter and Richard Layard, eds., Amsterdam, N.Y.: North

Risks and interrelationships of subdistrict house prices: the case of Amsterdam.

PubMed

Teye, Alfred Larm; de Haan, Jan; Elsinga, Marja G

2018-01-01

This paper uses individual house transaction data from 1995 to 2014 in Amsterdam to explore the risks and interrelationships of the subdistrict house prices. Simple indicators suggest that house prices grow faster and are more risky in the central business district and its immediate surrounding areas than in the peripherals. Furthermore, we observe an over time decreasing intervariations between the subdistrict house price growth rates, whereas we find a lead-lag and house price causal flow from the more central to the peripheral subdistricts.

Presence of human non-polio enterovirus and parechovirus genotypes in an Amsterdam hospital in 2007 to 2011 compared to national and international published surveillance data: a comprehensive review.

PubMed

Janes, V A; Minnaar, R; Koen, G; van Eijk, H; Dijkman-de Haan, K; Pajkrt, D; Wolthers, K C; Benschop, K S

2014-11-20

Enteroviruses (EV) and human parechoviruses (HPeV) are endemic worldwide. These infections are a constant cause of hospitalisation and severe disease, predominantly in young children and infants. Coordinated monitoring and surveillance are crucial to control these infections. We have monitored EV and HPeV epidemiology in Amsterdam from 2007 to 2011 with real-time RT-PCR and direct genotyping, facilitating highly sensitive surveillance. Moreover, we conducted a literature survey of existing surveillance data for comparison. Only 14 studies were identified. While HPeV1 was most frequently detected in Amsterdam, EV-B viruses dominated nationally and internationally. Furthermore, the top 10 strains detected differed yearly and per study. However, detection and typing methods were too varied to allow direct comparison and comprehension of the worldwide distribution and circulation patterns of the different genotypes. This limited a direct response to anticipate peaks. Uniform European monitoring programmes are essential to aid prediction of outbreaks and disease management.

How much for a dime bag? An exploration of youth drug markets.

PubMed

Harrison, Lana D; Erickson, Patricia G; Korf, Dirk J; Brochu, Serge; Benschop, Annemieke

2007-09-01

Relatively little is known about how youth obtain marijuana and other drugs. The Drugs, Alcohol and Violence International (DAVI) study explored youthful drug markets among samples of school students, detained youth, and school dropouts (ages 14-17 years) in the greater metropolitan areas of Philadelphia, Toronto, Montreal, and Amsterdam. Students frequently reported sharing drugs, either getting them from others or giving them to others for free. Sharing was less common among the more drug-involved detainees and dropouts. Marijuana was typically obtained either outdoors or in a house or apartment. Few youth reported getting marijuana at school. In Amsterdam, where marijuana can be purchased in small quantities in coffeeshops, this was the most common place to get marijuana, even though 18 is the legal age for purchase. Alcohol was also most likely to be obtained in stores or restaurants across all the sites, even though none were of legal age except those in Amsterdam age 16 or older. Youth most often reported purchasing marijuana in nickel, dime or other small bags, which are not standardized units. The exception again was Amsterdam, where youth most often reported quantities in grams or joints, which is how it is sold in coffeeshops. The lack of standardization of units makes economic cost estimates suspect. Even standardized units such as alcohol present problems since youth report a wide range of 'typical purchases.' Survey data can, however, more aptly describe drug market characteristics such as general location of purchase, and relationship with the seller.

Ethnic differences in HSV1 and HSV2 seroprevalence in Amsterdam, the Netherlands.

PubMed

Kramer, M A; Uitenbroek, D G; Ujcic-Voortman, J K; Pfrommer, C; Spaargaren, J; Coutinho, R A; Dukers-Muijrers, N H T M

2008-06-12

Herpes simplex virus type 1 (HSV1) and 2 (HSV2) infection can lead to significant morbidity, and HSV2 is considered a risk factor for HIV transmission. The majority of HSV-infected people are asymptomatic and unaware of their infection. We aimed to determine the HSV1 and HSV2 prevalence among various ethnic groups in a large urban area in the Netherlands. In 2004, serum samples from a population-based serum repository of 1,325 people over 18 years living in Amsterdam were tested for HSV1 and HSV2 antibodies in order to determine high-risk groups. Prevalence ratios were estimated and all analyses were weighted by sex, age, and ethnicity. In the general population of Amsterdam, 67% had HSV1 antibodies, 22% had HSV2 antibodies, 15% had HSV1 and HSV2 antibodies, and 26% had no indication of HSV infection. In multivariate analyses, HSV1 seroprevalence increased with age, and was higher among people of Turkish and Moroccan origin, homosexual men, and individuals with low educational level. HSV2 seroprevalence was associated with increasing age, Surinamese/Antillean background, and having a history of sexually transmitted infections (STI). These differences between ethnic groups in Amsterdam regarding the distribution of HSV1 and HSV2 infection emphasise the importance of an ethnic-specific approach of serological testing as well as campaigns aimed at behavioural change and counselling to raise awareness of the risk of HSV transmission.

Hereditary non-polyposis colorectal cancer/Lynch syndrome in three dimensions.

PubMed

Kravochuck, Sara E; Church, James M

2017-12-01

Hereditary non-polyposis colorectal cancer (HNPCC) is defined by family history, and Lynch syndrome (LS) is defined genetically. However, universal tumour testing is now increasingly used to screen for patients with defective mismatch repair. This mixing of the results of family history, tumour testing and germline testing produces multiple permutations and combinations that can foster confusion. We wanted to clarify hereditary colorectal cancer using the three dimensions of classification: family history, tumour testing and germline testing. Family history (Amsterdam I or II criteria versus not Amsterdam criteria) was used to define patients and families with HNPCC. Tumour testing and germline testing were then performed to sub-classify patients and families. The permutations of these classifications are applied to our registry. There were 234 HNPCC families: 129 had LS of which 55 were three-dimensional Lynch (family history, tumour testing and germline testing), 66 were two-dimensional Lynch and eight were one-dimensional Lynch. A total of 10 families had tumour Lynch (tumours with microsatellite instability or loss of expression of a mismatch repair protein but an Amsterdam-negative family and negative germline testing), five were Lynch like (Amsterdam-positive family, tumours with microsatellite instability or loss of expression of a mismatch repair protein on immunohistochemistry but negative germline testing), 26 were familial colorectal cancer type X and 95 were HNPCC. Hereditary colorectal cancer can be confusing. Sorting families in three dimensions can clarify the confusion and may direct further testing and, ultimately, surveillance. © 2016 Royal Australasian College of Surgeons.

Problemes theoriques et methodologiques dans l'etude des langues/dialectes en contact aux niveaux macrologique et micrologique = Theoretical and Methodological Issues in the Study of Languages/Dialects in Contact at Macro- and Micro-Logical Levels of Analysis. Proceedings of the International Conference DALE (University of London)/ICRB (Laval University, Quebec)/ICSBT (Vrije Universiteit te Brussel) (London, England, May 23-26, 1985).

ERIC Educational Resources Information Center

Blanc, Michel, Ed.; Hamers, Josiane F., Ed.

Papers from an international conference on the interaction of languages and dialects in contact are presented in this volume. Papers include: "Quelques reflexions sur la variation linguistique"; "The Investigation of 'Language Continuum' and 'Diglossia': A Macrological Case Study and Theoretical Model"; "A Survey of…

Key paediatric messages from Amsterdam

PubMed Central

Barben, Jürg; Bohlin, Kajsa; Everard, Mark L.; Hall, Graham; Pijnenburg, Mariëlle; Priftis, Kostas N.; Rusconi, Franca; Midulla, Fabio

2016-01-01

The Paediatric Assembly of the European Respiratory Society (ERS) maintained its high profile at the 2015 ERS International Congress in Amsterdam. There were symposia on preschool wheeze, respiratory sounds and cystic fibrosis; an educational skills workshop on paediatric respiratory resuscitation; a hot topic session on risk factors and early origins of respiratory diseases; a meet the expert session on paediatric lung function test reference values; and the annual paediatric grand round. In this report the Chairs of the Paediatric Assembly's Groups highlight the key messages from the abstracts presented at the Congress. PMID:27730186

A report from the 20th United European Gastroenterology Week 2012 (October 20-24, 2012 - Amsterdam, the Netherlands).

PubMed

Escorsell, J

2012-12-01

This year saw the 20th anniversary of the first United European Gastroenterology Week (UEGW), the largest European conference focused on diseases of the stomach, bowel, esophagus, liver, pancreas and gallbladder. UEGW 2012, which was held in Amsterdam, the Netherlands, attracted over 14,000 delegates who discussed recent developments in the treatment of these diseases, including multidisciplinary care and the effect of obesity and alcohol on gastrointestinal and liver diseases. Copyright 2012 Prous Science, S.A.U. or its licensors. All rights reserved.

Cost-Effectiveness of Group and Internet Cognitive Behavioral Therapy for Insomnia in Adolescents: Results from a Randomized Controlled Trial

PubMed Central

De Bruin, Eduard J.; van Steensel, Francisca J.A.; Meijer, Anne Marie

2016-01-01

Study Objectives: To investigate cost-effectiveness of adolescent cognitive behavioral therapy for insomnia (CBTI) in group- and Internet-delivered formats, from a societal perspective with a time horizon of 1 y Methods: Costs and effects data up to 1-y follow-up were obtained from a randomized controlled trial (RCT) comparing Internet CBTI to face-to-face group CBTI. The study was conducted at the laboratory of the Research Institute of Child Development and Education at the University of Amsterdam, and the academic youth mental health care center UvAMinds in Amsterdam. Sixty-two participants meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria for insomnia were randomized to face-to-face group CBTI (GT; n = 31, age = 15.6 y ± 1.8, 71.0% girls) or individual Internet CBTI (IT; n = 31, age = 15.4 y ± 1.5, 83.9% girls). The intervention consisted of six weekly sessions and a 2-mo follow up booster-session of CBTI, consisting of psychoeducation, sleep hygiene, restriction of time in bed, stimulus control, cognitive therapy, and relaxation techniques. GT sessions were held in groups of six to eight adolescents guided by two trained sleep therapists. IT consisted of individual Internet therapy with preprogrammed content similar to GT, and guided by trained sleep therapists. Results: Outcome measures were subjective sleep efficiency (SE) ≥ 85%, and quality-adjusted life-years (QALY). Analyses were conducted from a societal perspective. Incremental cost-effectiveness ratios (ICERs) were calculated using bootstrap sampling, and presented in cost-effectiveness planes. Primary analysis showed costs over 1 y were higher for GT but effects were similar for IT and GT. Bootstrapped ICERs demonstrated there is a high probability of IT being cost-effective compared to GT. Secondary analyses confirmed robustness of results. Conclusions: Internet CBTI is a cost-effective treatment compared to group CBTI for adolescents, although effects were largely similar for both formats. Further studies in a clinical setting are warranted. Clinical Trial Registration: ID: ISRCTN33922163; trial name: Effectiveness of cognitive behavioral therapy for sleeplessness in adolescents; URL: http://www.isrctn.com/ISRCTN33922163 Citation: De Bruin EJ, van Steensel FJ, Meijer AM. Cost-effectiveness of group and internet cognitive behavioral therapy for insomnia in adolescents: results from a randomized controlled trial. SLEEP 2016;39(8):1571–1581. PMID:27306272

The impact of inland ships and recreational boats on measured NOx and ultrafine particle concentrations along the waterways

NASA Astrophysics Data System (ADS)

van der Zee, Saskia C.; Dijkema, Marieke B. A.; van der Laan, Jorrit; Hoek, Gerard

2012-08-01

In Amsterdam, many inhabitants reside in proximity to inland waters. The aim of this study was to assess the impact of passing inland ships and recreational boats, including touring boats, on the air quality near houses close to the water. A measurement campaign was performed at five sites in Amsterdam. Two sites were located along the inland waterways used by cargo ships and recreational boats. The other three sites were located along the canals in the historical city centre, used by touring boats and private recreational boats. At each site, measurements were performed at the waterside and at the facade of houses. Nitrogen oxides (NO and NO2) and ultrafine particles (particle number (PN) concentration), were measured continuously during one afternoon per site, while time and type of passing ships and road traffic was registered. Linear regression analysis was used to analyze the association between passing ships and concentration, adjusted for passing road traffic. There was substantial variation in the impact of passing ships on concentrations at each measuring site, as well as between sites. On average, cargo ships contributed 5 and 4 μg m-3 to NO and NO2, respectively, and 3000 particles cm-3 to PN concentration near houses during the sampling period. Peak concentrations were occasionally substantially higher. Emissions from touring boats had a small but significant impact on NO concentration near houses but not on NO2, with the exception of one site located near the edge of two canals, where boats use extra power to travel around the bent. At this site, touring boats contributed 5 μg m-3 to the local NO2 concentration. No consistent impact of touring boats on PN concentration was observed. Emissions from private recreational boats were not consistently associated with increased NOx or PN concentration. Road traffic intensity was low at the selected measurement sites. Nevertheless, a significant impact of passing diesel-operated delivery vans on house adjacent concentrations of both NOx and PN concentrations was found. On average, mopeds had a small but significant impact on PN concentration by 1100 particles cm-3 In conclusion, this study provides evidence that ship exhausts has an impact on air quality near houses along waterways.

[The Amsterdam wrist rules: the multicenter prospective derivation and external validation of a clinical decision rule for the use of radiography in acute wrist trauma].

PubMed

Walenkamp, Monique M J; Bentohami, Abdelali; Slaar, Annelie; Beerekamp, M S H Suzan; Maas, Mario; Jager, L C Cara; Sosef, Nico L; van Velde, Romuald; Ultee, Jan M; Steyerberg, Ewout W; Goslings, J C Carel; Schep, Niels W L

2016-01-01

Although only 39% of patients with wrist trauma have sustained a fracture, the majority of patients is routinely referred for radiography. The purpose of this study was to derive and externally validate a clinical decision rule that selects patients with acute wrist trauma in the Emergency Department (ED) for radiography. This multicenter prospective study consisted of three components: (1) derivation of a clinical prediction model for detecting wrist fractures in patients following wrist trauma; (2) external validation of this model; and (3) design of a clinical decision rule. The study was conducted in the EDs of five Dutch hospitals: one academic hospital (derivation cohort) and four regional hospitals (external validation cohort). We included all adult patients with acute wrist trauma. The main outcome was fracture of the wrist (distal radius, distal ulna or carpal bones) diagnosed on conventional X-rays. A total of 882 patients were analyzed; 487 in the derivation cohort and 395 in the validation cohort. We derived a clinical prediction model with eight variables: age; sex, swelling of the wrist; swelling of the anatomical snuffbox, visible deformation; distal radius tender to palpation; pain on radial deviation and painful axial compression of the thumb. The Area Under the Curve at external validation of this model was 0.81 (95% CI: 0.77-0.85). The sensitivity and specificity of the Amsterdam Wrist Rules (AWR) in the external validation cohort were 98% (95% CI: 95-99%) and 21% (95% CI: 15%-28). The negative predictive value was 90% (95% CI: 81-99%). The Amsterdam Wrist Rules is a clinical prediction rule with a high sensitivity and negative predictive value for fractures of the wrist. Although external validation showed low specificity and 100 % sensitivity could not be achieved, the Amsterdam Wrist Rules can provide physicians in the Emergency Department with a useful screening tool to select patients with acute wrist trauma for radiography. The upcoming implementation study will further reveal the impact of the Amsterdam Wrist Rules on the anticipated reduction of X-rays requested, missed fractures, Emergency Department waiting times and health care costs.

Economic evaluation of the randomized European Achalasia trial comparing pneumodilation with Laparoscopic Heller myotomy.

PubMed

Moonen, A; Busch, O; Costantini, M; Finotti, E; Tack, J; Salvador, R; Boeckxstaens, G; Zaninotto, G

2017-11-01

A recent multicenter randomized trial in achalasia patients has shown that pneumatic dilation resulted in equivalent relief of symptoms compared to laparoscopic Heller myotomy. Additionally, the cost of each treatment should be also taken in consideration. Therefore, the aim of the present study was to perform an economic analysis of the European achalasia trial. Patients with newly diagnosed achalasia were enrolled from to 2003 to 2008 in 14 centers in five European countries and were randomly assigned to either pneumatic dilation (PD) or laparoscopic Heller (LHM). The economic analysis was performed in the three centers in three different countries where most patients were enrolled (Amsterdam [NL], Leuven, [B] and Padova [I]) and then applied to all patients included in the study. The total raw costs of the two treatments per patient include the initial costs, the costs of complications, and the costs of retreatments. Two hundred and one patients, 107 (57 males and 50 females, mean age 46 CI: 43-49 years) were randomized to LHM and 94 (59 males and 34 females, mean age 46 CI 43-50 years) to PD. The total cost of PD per patient was quite comparable in the three different centers; €3397 in Padova, €3259 in Amsterdam and €3792 in Leuven. For LHM, the total costs per patient were highest in Amsterdam: €4488 in Padova, €6720 in Amsterdam, and €5856 in Leuven. In conclusion, the strategy of treating achalasia starting with PD appears the most economic approach, independent of the health system. © 2017 John Wiley & Sons Ltd.

[Anatomy as theatre. From the library of the Society of the Dutch Journal of Medicine. Govard Bidloo: Ontleding des Menschelijken Lichaams (Dissection of the Human Body); 1689; and William Cowper: The Anatomy of Humane Bodies; 1698].

PubMed

Molenaar, J C

2004-12-25

Opinions differ regarding the scientific quality of the atlas by Govard Bidloo, Ontleding des Menschelijken Lichaams (Dissection of the Human Body) (1689) and the plagiarism made thereof by William Cowper, The Anatomy of Humane Bodies (1698). Both books were also published in Latin; the Society of the Dutch Journal of Medicine has acquired a copy of all 4 atlases. The anatomical plates were made by the artist Gerard de Lairesse (Liège 1640-Amsterdam 1711) and their great artistic value is beyond all doubt. De Lairesse settled in Amsterdam in 1665, a few months after the reopening of the city theatre, and subsequently achieved fame as an innovative creator of theatre sets. He also became one of the favourite artists of prince William III and many other well-to-do citizens of Amsterdam. The great artistic value of his anatomical plates justifies more attention for his importance as a medical illustrator in medical history.

The association between physical environment and cycling to school among Turkish and Moroccan adolescents in Amsterdam.

PubMed

Mäki-Opas, Tomi E; de Munter, Jeroen; Maas, Jolanda; den Hertog, Frank; Kunst, Anton E

2014-08-01

This study examined the effect of physical environment on cycling to and from school among boys and girls of Turkish and Moroccan origin living in Amsterdam. The LASER study (n = 697) was an interview study that included information on cycling to and from school and the perceived physical environment. Objective information on physical environment was gathered from Statistics Netherlands and the Department for Research and Statistics at the Municipality of Amsterdam. Structural equation modelling with latent variables was applied, taking into account age, gender, self-assessed health, education, country of origin, and distance to school. For every unit increase in the latent variable scale for bicycle-friendly infrastructure, we observed a 21% increase in the odds for cycling to and from school. The association was only borderline statistically significant and disappeared after controlling for distance to school. The enjoyable environment was not associated with cycling to and from school after controlling for all background factors. Bicycle-friendly infrastructure and an enjoyable environment were not important factors for cycling to and from school among those with no cultural cycling background.

A report from the European Society of Cardiology Congress 2013 (August 31-September 4, 2013 - Amsterdam, the Netherlands).

PubMed

Rabasseda, X

2013-09-01

Many are the diseases that can affect the heart and the vessels, most of which were discussed during the European Society of Cardiology Congress 2013 in Amsterdam. With an attendance of almost 30,000 delegates buzzing the halls of the RAI convention center, Amsterdam was the capital of cardiologic science this summer, and a big challenge for any attendee trying to get the most out of all the oral and poster sessions missing the minimum of new science being presented. Thomson Reuters Cortellis™ supplements the information for any scientist who missed an important session, with a particular focus on new investigational drugs, many of them still in preclinical research, which will certainly impact how cardiovascular disorders are treated in a foreseeable future. Clinical and preclinical research advance to bring novel therapeutic targets, new drugs and new insight into patient characteristics requiring particular treatment approaches. This report is a sample of the new science discussed during the 5 days of meetings. Copyright 2013 Prous Science, S.A.U. or its licensors. All rights reserved.

Poor peer relations predict parent- and self-reported behavioral and emotional problems of adolescents with gender dysphoria: a cross-national, cross-clinic comparative analysis.

PubMed

de Vries, Annelou L C; Steensma, Thomas D; Cohen-Kettenis, Peggy T; VanderLaan, Doug P; Zucker, Kenneth J

2016-06-01

This study is the third in a series to examine behavioral and emotional problems in children and adolescents with gender dysphoria in a comparative analysis between two clinics in Toronto, Ontario, Canada and Amsterdam, the Netherlands. In the present study, we report Child Behavior Checklist (CBCL) and Youth Self-Report (YSR) data on adolescents assessed in the Toronto clinic (n = 177) and the Amsterdam clinic (n = 139). On the CBCL and the YSR, we found that the percentage of adolescents with clinical range behavioral and emotional problems was higher when compared to the non-referred standardization samples but similar to the referred adolescents. On both the CBCL and the YSR, the Toronto adolescents had a significantly higher Total Problem score than the Amsterdam adolescents. Like our earlier studies of CBCL data of children and Teacher's Report Form data of children and adolescents, a measure of poor peer relations was the strongest predictor of CBCL and YSR behavioral and emotional problems in gender dysphoric adolescents.

The effect of chronic administration of sarizotan, 5-HT1A agonist/D3/D4 ligand, on haloperidol-induced repetitive jaw movements in rat model of tardive dyskinesia.

PubMed

Rosengarten, Helen; Bartoszyk, Gerd D; Quartermain, David; Lin, Yan

2006-03-01

Dyskinesia is the most troublesome side effect in long-term treatment of both Parkinson's disease (PD) and schizophrenia. The 5-HT1A agonist and D3/D4 ligand sarizotan [Bartoszyk, G.D., van Amsterdam, C., Greiner, H.E., Rautenberg, W., Russ, H., Seyfried, C.A., 2004. Sarizotan, a serotonin 5-HT1A receptor agonist and dopamine receptor ligand. 1. Neurochemical profile. J. Neural Transm. 111, 113-126.] is in clinical development for the treatment of PD-associated dyskinesia. Because 5-HT1A agonists are known to counteract antipsychotic-induced motor side effects, sarizotan was investigated for its effects in two rat models of tardive dyskinesia (TD). The acute administration of sarizotan (0.17-13.5 mg/kg i.p.) reduced episodes of SKF 38393-induced repetitive jaw movements (RJM) in rats with a maximal effect at 1.5 mg/kg. In a chronic study, sarizotan (0.04-9 mg/kg/day), administered in the drinking water for 7 weeks during withdrawal from chronic haloperidol treatment (1.5 mg/kg/day), dose-dependently reversed haloperidol-induced RJM, significant at the doses of 1.5 and 9 mg/kg. Agonism at 5-HT1A receptors may be mediating the inhibitory effect of sarizotan on RJM in rat models of tardive dyskinesia.

Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study.

PubMed

Sadik, S; van Rijckevorsel, G G C; van Rooijen, M S; Sonder, G J B; Bruisten, S M

2016-11-08

In the last decade hepatitis E virus (HEV) is increasingly recognized as a cause of acute viral hepatitis in developed countries. HEV is transmitted via the fecal-oral route. In countries like the Netherlands, HEV infection is suspected to be a zoonosis but HEV may also be introduced by migrants. We studied the seroprevalence of HEV among different migrants, mainly Moroccans and Turks, and compared this to that of the native Dutch population in Amsterdam, the Netherlands. Data were obtained from a cross-sectional survey of the adult Amsterdam population performed in 2004; the Amsterdam Health Monitor. A total of 1199 plasma samples were tested for IgG-and IgM antibodies to HEV using the Wantai kit according to instructions of the manufacturer. Basic demographic data (gender, age, country of birth, and age at immigration) were used in the analyses. Hepatitis A virus (HAV) serology data were available from a previous study. The total weighted anti-HEV IgG seroprevalence in the overall Amsterdam population was 26.7 %, based on 1199 samples. In the study population (not-weighted) this HEV seroprevalence was 157/426 (36.9 %) for the Dutch participants and it was 161/257 (62.6 %) for Moroccans, 99/296 (33.4 %) for Turks and 42/220 (19.1 %) for other ethnicities. HEV seroprevalence increased significantly with age. First-generation Moroccan migrants (44.0 %) had a significantly higher weighted HEV seroprevalence than the Dutch participants (29.7 %). In the first generation Turks (20.3 %) and first generation migrants from other countries (16.7 %) this weighted seroprevalence was lower, but this was only significant for the 'other ethnicities'. The median age of migration was significantly higher in the Moroccan and Turkish migrants who were HEV IgG positive versus HEV IgG negative. However, when stratifying for age at time of study, median migration age was only significantly different for HEV sero-status for younger Turks and younger 'other ethnicities'. HEV IgM antibodies were found in 0.6 % (n = 7) of participants and none were positive for HEV RNA, showing that there were no acute infections. Despite the common route of fecal-oral transmission for both viruses, there was no relation between HEV and HAV seropositivity. Within the multi-ethnical capital city of Amsterdam the HEV seroprevalence in first generation migrant populations differed from each other and from the autochthonous Dutch population. The relation between being HEV seropositive and a higher median age of migration suggests that younger migrants got more often infected in their country of origin than in the Netherlands.

The lithospheric-scale 3D structural configuration of the North Alpine Foreland Basin constrained by gravity modelling and the calculation of the 3D load distribution

NASA Astrophysics Data System (ADS)

Przybycin, Anna M.; Scheck-Wenderoth, Magdalena; Schneider, Michael

2014-05-01

The North Alpine Foreland Basin is situated in the northern front of the European Alps and extends over parts of France, Switzerland, Germany and Austria. It formed as a wedge shaped depression since the Tertiary in consequence of the Euro - Adriatic continental collision and the Alpine orogeny. The basin is filled with clastic sediments, the Molasse, originating from erosional processes of the Alps and underlain by Mesozoic sedimentary successions and a Paleozoic crystalline crust. For our study we have focused on the German part of the basin. To investigate the deep structure, the isostatic state and the load distribution of this region we have constructed a 3D structural model of the basin and the Alpine area using available depth and thickness maps, regional scale 3D structural models as well as seismic and well data for the sedimentary part. The crust (from the top Paleozoic down to the Moho (Grad et al. 2008)) has been considered as two-parted with a lighter upper crust and a denser lower crust; the partition has been calculated following the approach of isostatic equilibrium of Pratt (1855). By implementing a seismic Lithosphere-Asthenosphere-Boundary (LAB) (Tesauro 2009) the crustal scale model has been extended to the lithospheric-scale. The layer geometry and the assigned bulk densities of this starting model have been constrained by means of 3D gravity modelling (BGI, 2012). Afterwards the 3D load distribution has been calculated using a 3D finite element method. Our results show that the North Alpine Foreland Basin is not isostatically balanced and that the configuration of the crystalline crust strongly controls the gravity field in this area. Furthermore, our results show that the basin area is influenced by varying lateral load differences down to a depth of more than 150 km what allows a first order statement of the required compensating horizontal stress needed to prevent gravitational collapse of the system. BGI (2012). The International Gravimetric Bureau. IAG Geodesist's Handbook, 2012 - Journal of Geodesy, 86(10) Springer Grad, M., Tiira, T. and ESC Working Group (2009). The Moho depth map of 1 the European Plate. Geophysical Journal International 176(1): 279-292. Tesauro, M. (2009). An integrated study of the structure and thermomechanical properties of the European lithosphere. Department of Tectonics Faculty of Earth & Life Sciences. Amsterdam, Vrije Universiteit, Dissertation

The role of the memory inherited by the system from the Cretaceous-Tertiary evolution of convergent margins into the build-up of the Source area (Apuseni Mountains, Romania).

NASA Astrophysics Data System (ADS)

Reiser, Martin; Fügenschuh, Bernhard; Schuster, Ralf

2010-05-01

The Apuseni mountains in Romania take a central position in the Alpine Carpathian Dinaride system and separate the Pannonian basin in the west from the Transsylvanian basin in the east. The Cretaceous age nappe stack involves from bottom to top Tisza- (Bihor and Codru) and Dacia-derived units (Biharia, according to Schmid et al., 2008) overlain by the South Apuseni and Transylvanian ophiolite belt. This study tries to provide new and additional information on the structural and metamorphic evolution of these units from the Jurassic obduction to neotectonic activity. This also comprises information on their interaction with the neighbouring basins. The objective is to show the impact of large scale (plate) tectonics (f.i. in terms of its thermal configuration and strengths profile) and the impact of early-formed tectonic features for the further evolution, specifically the formation of the surrounding basins together with its feedback with topography. This approach includes investigation of kinematics along first order contacts during distinct events together with the thermotectonic characterization of the involved units. While the early "high-grade" evolution will be geochronologically addressed by Sm/Nd, Rb/Sr and Ar/Ar dating, fission track analysis on zircon and apatite will be used to constrain the low-temperature part of the story. Already available data by Sanders (1998), Schuller (2004), Merten (in preparation) and Kounov (in preparation) together with new own data will be used to provide a 4D model for the late-stage thermal evolution of the Apuseni mountains. Thermal modelling will be compared and integrated with numerical modelling of the landscape evolution. The hereby generated data and information on erosion and exhumation will be further used in associated partner projects of the Source to Sink research network which addresses the evolution of the Danube system from the hinterland to the Black Sea. References: Sanders, C. A. E. (1998), Tectonics and erosion - Competitive forces in a compressive orogen: A fission track study of the Romanian Carpathians, PhD-thesis, Vrije Universiteit, Amsterdam, pp. 204. Schuller, V. (2004), Evolution and geodynamic significance of the Upper Cretaceous Gosau basin in the Apuseni Mountains (Romania), PhD Thesis, Tubinger Geowiss. Arb. Reihe A70, 112 pp. Schmid, S. M., D. Bernoulli, B. Fügenschuh, L. Matenco, S. Schaefer, R. Schuster, M. Tischler and K. Ustaszewski (2008), The Alps-Carpathians-Dinaridic orogenic system: correlation and evolution of tectonic units, Swiss Journal of Geosciences, 2008.

[Incidence of cervical cancer in women in North-Holland by country of birth from 1988-1998].

PubMed

Visser, O; Busquet, E H; van Leeuwen, F E; Aaronson, N K; Ory, F G

2003-01-11

To describe the incidence of cervical cancer in women in North-Holland by country of birth. Descriptive epidemiological study based on data from cancer registries. The number of cases of cervical cancer in North-Holland for the period 1988-1998 was determined using data from the regional cancer registry of the Comprehensive Cancer Centre, Amsterdam. Based on data from the Netherlands Cancer Registry, a comparison was made between the observed (O) and the expected (E) number of cases by area of residence (i.e., Amsterdam versus the rest of North-Holland) and by the woman's country of birth. In the period 1988-1998, the incidence of cervical cancer among women living in North-Holland was significantly higher than that of the nation as a whole (O/E-ratio: 1.2; 95% CI: 1.1-1.2). In particular, the incidence of cervical cancer for women living in Amsterdam (O/E-ratio: 1.5; 95% CI: 1.4-1.6), and for women born in Morocco (O/E-ratio: 2.1; 95% CI: 1.4-3.1) or Surinam (O/E-ratio: 1.5; 95% CI: 1.1-2.0) was much higher. The country of birth was unknown in 10% of the women. The percentage of patients with extension of the disease outside the uterus (TNM-stages II-IV) did not differ between women born in the Netherlands and those born abroad. The incidence of cervical cancer during the period 1988-1998 was significantly higher for women living in Amsterdam and for women born in Morocco or Surinam than that for the Netherlands as a whole. No significant difference in stage of disease at diagnosis was observed between women born in the Netherlands versus those born abroad.

Preface: Proceedings of the Colloidal Dispersions in External Fields II Conference (Bonn-Bad Godesberg, 31 March 2 April 2008)

NASA Astrophysics Data System (ADS)

Löwen, H.

2008-10-01

This special issue reflects the scientific programme of the International Colloidal Dispersions in External Fields Conference (CODEF II) that took place in Bonn-Bad Godesberg from 31 March-2 April 2008. This is the second conference in a series that started in 2004 when the first CODEF meeting was held. The proceedings of the first CODEF meeting were summarized in a previous special issue (Journal of Physics: Condensed Matter 16 (issue 38)). The present issue represents recent progress in this rapidly developing field. The CODEF meeting series is held in conjunction with the German-Dutch Transregional Collaborative Research Centre SFB TR6 with the title Physics of Colloidal Dispersions in External Fields. Scientists working within this network as well as international invited guest speakers contributed to these meetings. The contributions in this issue are organized according to the type of different fields applied namely: bulk (no external field) shear flow electric field magnetic and laser-optical field confinement We would like to thank the CODEF II sponsors (Deutsche Forschungsgemeinschaft and MWFZ Mainz) for their financial support. Furthermore, we thank IOP Publishing for their willingness to publish the proceedings of this conference as a special issue. Participants O Alarcón-Waess (Puebla), M Allen (Coventry), J L Arauz-Lara (San Luis Potosi), L Assoud (Düsseldorf), G K Auernhammer (Mainz), R Backofen (Dresden), M Balbás-Gambra (Munich), J Bammert (Bayreuth), M Baptista (Mainz), J-L Barrat (Lyon), M Bier (Utrecht), K Binder (Mainz), R Blaak (Düsseldorf), V Blickle (Stuttgart), D Block (Kiel), S Böhm (Düsseldorf), V Botan (Mainz), J P Bouchaud (Paris), J Brader (Konstanz), G Brambilla (Montpellier), W J Briels (Enschede), M Brinkmann (Göttingen), C Brunet (Paris), H-J Butt (Mainz), M A Camargo Chaparro (Düsseldorf), R Castañeda Priego (Guanajuato), J J Cerdà Pino (Frankfurt), A Chatterji (Jülich), M Chavez Paez (San Luis Potosi), A Chremos (Edinburgh), D Y H Chui (Mainz), D Deb (Graz), C Dellago (Vienna), J Dhont (Jülich), P Dillmann (Konstanz), G Dominguez (Leipzig), M Duits (Enschede), B Dünweg (Mainz), F Ebert (Konstanz), S Egelhaaf (Düsseldorf), E Eggen (Utrecht), R Eichhorn (Bielefeld), E Eiser (Cambridge), H B Eral (Enschede), A Erbe (Konstanz), L Filion (Utrecht), G Foffi (Lausanne), J Fornleitner (Vienna), K Franzrahe (Konstanz), D Frenkel (Cambridge), M Fuchs (Konstanz), G Fytas (Heraklion), P Garstecki (Warsaw), I Gazuz (Konstanz), N Geerts (Amsterdam), G Gompper (Jülich), E Gonzalez-Tovar (San Luis Potosi), I Götze (Jülich), S Grandner (Berlin), L Gránásy (London), C Gutsche (Leipzig), D Hajnal (Mainz), R Hanes (Düsseldorf), A Härtel (Düsseldorf), P Henseler (Konstanz), C Hertlein (Stuttgart), C Holm (Mainz), J Hoogenboom (Barcelona), P Hopkins (Bristol), J Horbach (Cologne), C-C Huang (Jülich), K Huang (Göttingen), S Huißmann (Düsseldorf), M Humar (Ljubljana), S Iacopini (Mainz), A Imhof (Utrecht), A Ivlev (Garching), K Jacobs (Saarbrücken), J Jakobi (Hannover), O Jansen (Düsseldorf), M Jenkins (Düsseldorf), J Jordanovic (Berlin), S Jungblut (Mainz), M Kahn (Vienna), T Kalwarczyk (Warsaw), K Kegler (Leipzig), P Keim (Konstanz), Z Keqin (Singapore), U F Keyser (Leipzig), T Köller (Mainz), K Kremer (Mainz), M Krüger (Konstanz), A Kuijk (Utrecht), P Lang (Jülich), M Laurati (Düsseldorf), W Lechner (Vienna), H Lehle (Stuttgart), P Leiderer (Konstanz), H Lekkerkerker (Utrecht), P Lettinga (Jülich), A Libal (San Mart), B Lonetti (Jülich), N J Lorenz (Mainz), H Löwen (Düsseldorf), H Maleki (Mainz), J-G Malherbe (Paris), M Marechal (Utrecht), G Maret (Konstanz), C Mayer (Rome), S Mazoyer (Konstanz), M McPhie (Jülich), M Medina-Noyola (San Luis Potosi), A Melzer (Greifswald), A Menéndez-Manjón (Hannover), R Messina (Düsseldorf), H Michiel (Utrecht), P Mishra (Düsseldorf), J Mixteco (Guanajuato), B Moser (Düsseldorf), G Nägele (Jülich), R R Netz (Munich), P Nielaba (Konstanz), E Noruzifar (Mainz), M Oettel (Mainz), O Otto (Leipzig), S Overduin (Düsseldorf), E C Oğuz (Düsseldorf), T Palberg (Mainz), G Pauschenwein (Vienna), G Pellicane (Messina), F Pesth (Mainz), P Pfleiderer (Mainz), D J Pine (New York), D Pini (Milan), H Reiber (Mainz), V Reshetnyak (Kiev), M Rex (Düsseldorf), M Ripoll (Jülich), M Roth (Mainz), P Royall (Bristol), M Rubin-Zuzic (Garching), T Schilling (Mainz), A Schmidt (Düsseldorf), M Schmiedeberg (Berlin), H J Schöpe (Mainz), S Schreiber (Bayreuth), B Schumann (Düsseldorf), F Sciortino (Rome), L Shapran-Reiber (Mainz), M Siebenbürger (Bayreuth), S P Singh (New Delhi), R Siquieri (Aachen), F Smallenburg (Utrecht), I Snook (Melbourne), M Sperl (Cologne), J Stellbrink (Jülich), E Stiakakis (Jülich), T Szymborski (Warsaw), H Tanaka (Tokyo), P Tierno (Barcelona), U Tkalec (Ljubljana), A Tsigkri (Jülich), T Tückmantel (Düsseldorf), C Valeriani (Edinburgh), A van Blaaderen (Utrecht), E van den Pol (Utrecht), J van Meel (Amsterdam), P van Oostrum (Utrecht), R van Roij (Utrecht), S van Teeffelen (Düsseldorf), L Verhoeff (Utrecht), E Vermolen (Utrecht), R Vink (Göttingen), P Virnau (Mainz), T Voigtmann (Cologne), D Vollmer (Mainz), G J Vroege (Utrecht), H R Vutukuri (Utrecht), C Walz (Konstanz), M Walz (Erlangen), D A Weitz (Harvard), J Wenk (Düsseldorf), R Wensink (London), F Weyßer (Konstanz), L Willner (Jülich), R G Winkler (Jülich), A Wynveen (Düsseldorf), A Wysocki (Düsseldorf), J Zausch (Mainz), J Zhao (Mainz), M Zietara (Konstanz), U Zimmermann (Düsseldorf), J Zwanikken (Utrecht).

Epidemiological study air disaster in Amsterdam (ESADA): study design.

PubMed

Slottje, Pauline; Huizink, Anja C; Twisk, Jos W R; Witteveen, Anke B; van der Ploeg, Henk M; Bramsen, Inge; Smidt, Nynke; Bijlsma, Joost A; Bouter, Lex M; van Mechelen, Willem; Smid, Tjabe

2005-05-30

In 1992, a cargo aircraft crashed into apartment buildings in Amsterdam, killing 43 victims and destroying 266 apartments. In the aftermath there were speculations about the cause of the crash, potential exposures to hazardous materials due to the disaster and the health consequences. Starting in 2000, the Epidemiological Study Air Disaster in Amsterdam (ESADA) aimed to assess the long-term health effects of occupational exposure to this disaster on professional assistance workers. Epidemiological study among all the exposed professional fire-fighters and police officers who performed disaster-related task(s), and hangar workers who sorted the wreckage of the aircraft, as well as reference groups of their non-exposed colleagues who did not perform any disaster-related tasks. The study took place, on average, 8.5 years after the disaster. Questionnaires were used to assess details on occupational exposure to the disaster. Health measures comprised laboratory assessments in urine, blood and saliva, as well as self-reported current health measures, including health-related quality of life, and various physical and psychological symptoms. In this paper we describe and discuss the design of the ESADA. The ESADA will provide additional scientific knowledge on the long-term health effects of technological disasters on professional workers.

Holocene multi-proxy environmental reconstruction from lake Hakluytvatnet, Amsterdamøya Island, Svalbard (79.5°N)

NASA Astrophysics Data System (ADS)

Gjerde, Marthe; Bakke, Jostein; D'Andrea, William J.; Balascio, Nicholas L.; Bradley, Raymond S.; Vasskog, Kristian; Ólafsdóttir, Sædis; Røthe, Torgeir O.; Perren, Bianca B.; Hormes, Anne

2018-03-01

High resolution proxy records of past climate are sparse in the Arctic due to low organic production that restricts the use of radiocarbon dating and challenging logistics that make data collection difficult. Here, we present a new lake record from lake Hakluytvatnet at Amsterdamøya island (79.5°N), the northwesternmost island on Svalbard. Multi-proxy analyses of lake sediments in combination with geomorphological mapping reveal large environmental shifts that have taken place at Amsterdamøya during the Holocene. A robust chronology has been established for the lake sediment core through 28 AMS radiocarbon ages, and this gives an exceptionally well-constrained age control for a lake at this latitude. The Holocene was a period with large changes in the Hakluytvatnet catchment, and the onset of the Neoglacial (ca. 5 ka) marks the start of modern-day conditions in the catchment. The Neoglacial is characterized by fluctuations in the minerogenic input to the lake as well as internal productivity, and we suggest that these fluctuations are driven by atmospherically forced precipitation changes as well as sea ice extent modulating the amount of moisture that can reach Hakluytvatnet.

Usage of purchased self-tests for HIV and sexually transmitted infections in Amsterdam, the Netherlands: results of population-based and serial cross-sectional studies among the general population and sexual risk groups

PubMed Central

Bil, Janneke P; Prins, Maria; Stolte, Ineke G; Dijkshoorn, Henriëtte; Heijman, Titia; Snijder, Marieke B; Davidovich, Udi; Zuure, Freke R

2017-01-01

Objectives There are limited data on the usage of commercially bought self-tests for HIV and other sexually transmitted infections (STIs). Therefore, we studied HIV/STI self-test usage and its determinants among the general population and sexual risk groups between 2007 and 2015 in Amsterdam, the Netherlands. Setting Data were collected in four different studies among the general population (S1–2) and sexual risk groups (S3–4). Participants S1–Amsterdam residents participating in representative population-based surveys (2008 and 2012; n=6044) drawn from the municipality register; S2–Participants of a population-based study stratified by ethnicity drawn from the municipality register of Amsterdam (2011–2015; n=17 603); S3–Men having sex with men (MSM) participating in an HIV observational cohort study (2008 and 2013; n=597) and S4–STI clinic clients participating in a cross-sectional survey (2007–2012; n=5655). Primary and secondary outcome measures Prevalence of HIV/STI self-test usage and its determinants. Results The prevalence of HIV/STI self-test usage in the preceding 6–12 months varied between 1% and 2% across studies. Chlamydia self-tests were most commonly used, except among MSM in S3. Chlamydia and syphilis self-test usage increased over time among the representative sample of Amsterdam residents (S1) and chlamydia self-test usage increased over time among STI clinic clients (S4). Self-test usage was associated with African Surinamese or Ghanaian ethnic origin (S2), being woman or MSM (S1 and 4) and having had a higher number of sexual partners (S1–2). Among those in the general population who tested for HIV/STI in the preceding 12 months, 5–9% used a self-test. Conclusions Despite low HIV/STI self-test usage, we observed increases over time in chlamydia and syphilis self-test usage. Furthermore, self-test usage was higher among high-risk individuals in the general population. It is important to continue monitoring self-test usage and informing the public about the unknown quality of available self-tests in the Netherlands and about the pros and cons of self-testing. PMID:28939577

The Amsterdam wrist rules: the multicenter prospective derivation and external validation of a clinical decision rule for the use of radiography in acute wrist trauma.

PubMed

Walenkamp, Monique M J; Bentohami, Abdelali; Slaar, Annelie; Beerekamp, M Suzan H; Maas, Mario; Jager, L Cara; Sosef, Nico L; van Velde, Romuald; Ultee, Jan M; Steyerberg, Ewout W; Goslings, J Carel; Schep, Niels W L

2015-12-18

Although only 39 % of patients with wrist trauma have sustained a fracture, the majority of patients is routinely referred for radiography. The purpose of this study was to derive and externally validate a clinical decision rule that selects patients with acute wrist trauma in the Emergency Department (ED) for radiography. This multicenter prospective study consisted of three components: (1) derivation of a clinical prediction model for detecting wrist fractures in patients following wrist trauma; (2) external validation of this model; and (3) design of a clinical decision rule. The study was conducted in the EDs of five Dutch hospitals: one academic hospital (derivation cohort) and four regional hospitals (external validation cohort). We included all adult patients with acute wrist trauma. The main outcome was fracture of the wrist (distal radius, distal ulna or carpal bones) diagnosed on conventional X-rays. A total of 882 patients were analyzed; 487 in the derivation cohort and 395 in the validation cohort. We derived a clinical prediction model with eight variables: age; sex, swelling of the wrist; swelling of the anatomical snuffbox, visible deformation; distal radius tender to palpation; pain on radial deviation and painful axial compression of the thumb. The Area Under the Curve at external validation of this model was 0.81 (95 % CI: 0.77-0.85). The sensitivity and specificity of the Amsterdam Wrist Rules (AWR) in the external validation cohort were 98 % (95 % CI: 95-99 %) and 21 % (95 % CI: 15 %-28). The negative predictive value was 90 % (95 % CI: 81-99 %). The Amsterdam Wrist Rules is a clinical prediction rule with a high sensitivity and negative predictive value for fractures of the wrist. Although external validation showed low specificity and 100 % sensitivity could not be achieved, the Amsterdam Wrist Rules can provide physicians in the Emergency Department with a useful screening tool to select patients with acute wrist trauma for radiography. The upcoming implementation study will further reveal the impact of the Amsterdam Wrist Rules on the anticipated reduction of X-rays requested, missed fractures, Emergency Department waiting times and health care costs. This study was registered in the Dutch Trial Registry, reference number NTR2544 on October 1(st), 2010.

Salinization may attack you from behind: upconing and related long-term downstream salinization in the Amsterdam Water Supply Dunes (Invited)

NASA Astrophysics Data System (ADS)

Olsthoorn, T.

2010-12-01

Groundwater from the Amsterdam Water Supply Dunes (GE: 52.35°N 4.55°E) has been used for the drinking water supply of Amsterdam since 1853. During the first half of the 20th century, severe intrusion and upconing occurred, with many of the wells turning brackish or saline. Already in 1903, the hydrologist/director of the Amsterdam Water Supply, Pennink, predicted this, based on his unique sand-box modeling, which he published in 1915 in the form of a large-size hard-bound book in four languages showing detailed black and white photographs of his tests. This book is now on the web: http://www.citg.tudelft.nl/live/pagina.jsp?id=68e12562-a4d2-489a-b82e-deca5dd32c42&lang=en Pennink devoted much of his work on saltwater upconing below wells, which he so feared. He simulated simultaneous flow of fresh and salt water, using milk to represent the saltwater having about the same density. With our current modeling tools, we can simulate his experiments, allowing to better understand his setup and even to verify our code. Pennink took interest in the way these cones form and in the point at which the salt water enters the screen. Surprizing, at least to many, is that this entry point is not necessarily the screen bottom. Measurements of the salinity distribution in salinized wells in the Amsterdam Water Supply Dune area confirmed this thirty years later when salinzation was severely occurring. The curved cone shape under ambient flow conditions provides part of the explanation why a short-term shut down of a well almost immediately diminishes salt concentrations, but salinization downstream of the wells in case with substantial lateral groundwater flow is not affected. Downstream salinization due to extraction was clearly shown in Pennink's experiments. However, the phenomenon seems still largely unknown or ignored. Downstream salinization also affects downstream heads for years after extraction has stopped. The presentation demonstrates and explains these local and more widespread phenomena using field data collected over time and verification by the numerical model. With substantial lateral flow salt water may well enter wells above the bottom of the screen.

Evaluation of intrinsic respiratory signal determination methods for 4D CBCT adapted for mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Rachael; Pan, Tinsu, E-mail: tpan@mdanderson.org; Rubinstein, Ashley

Purpose: 4D CT imaging in mice is important in a variety of areas including studies of lung function and tumor motion. A necessary step in 4D imaging is obtaining a respiratory signal, which can be done through an external system or intrinsically through the projection images. A number of methods have been developed that can successfully determine the respiratory signal from cone-beam projection images of humans, however only a few have been utilized in a preclinical setting and most of these rely on step-and-shoot style imaging. The purpose of this work is to assess and make adaptions of several successfulmore » methods developed for humans for an image-guided preclinical radiation therapy system. Methods: Respiratory signals were determined from the projection images of free-breathing mice scanned on the X-RAD system using four methods: the so-called Amsterdam shroud method, a method based on the phase of the Fourier transform, a pixel intensity method, and a center of mass method. The Amsterdam shroud method was modified so the sharp inspiration peaks associated with anesthetized mouse breathing could be detected. Respiratory signals were used to sort projections into phase bins and 4D images were reconstructed. Error and standard deviation in the assignment of phase bins for the four methods compared to a manual method considered to be ground truth were calculated for a range of region of interest (ROI) sizes. Qualitative comparisons were additionally made between the 4D images obtained using each of the methods and the manual method. Results: 4D images were successfully created for all mice with each of the respiratory signal extraction methods. Only minimal qualitative differences were noted between each of the methods and the manual method. The average error (and standard deviation) in phase bin assignment was 0.24 ± 0.08 (0.49 ± 0.11) phase bins for the Fourier transform method, 0.09 ± 0.03 (0.31 ± 0.08) phase bins for the modified Amsterdam shroud method, 0.09 ± 0.02 (0.33 ± 0.07) phase bins for the intensity method, and 0.37 ± 0.10 (0.57 ± 0.08) phase bins for the center of mass method. Little dependence on ROI size was noted for the modified Amsterdam shroud and intensity methods while the Fourier transform and center of mass methods showed a noticeable dependence on the ROI size. Conclusions: The modified Amsterdam shroud, Fourier transform, and intensity respiratory signal methods are sufficiently accurate to be used for 4D imaging on the X-RAD system and show improvement over the existing center of mass method. The intensity and modified Amsterdam shroud methods are recommended due to their high accuracy and low dependence on ROI size.« less

Large decline in injecting drug use in Amsterdam, 1986-1998: explanatory mechanisms and determinants of injecting transitions.

PubMed

van Ameijden, E J; Coutinho, R A

2001-05-01

To study community wide trends in injecting prevalence and trends in injecting transitions, and determinants. Open cohort study with follow up every four months (Amsterdam Cohort Study). Generalised estimating equations were used for statistical analysis. Amsterdam has adopted a harm reduction approach as drug policy. 996 drug users who were recruited from 1986 to 1998, mainly at methadone programmes, who paid 13620 cohort visits. The prevalence of injecting decreased exponentially (66% to 36% in four to six monthly periods). Selective mortality and migration could maximally explain 33% of this decline. Instead, injecting initiation linearly decreased (4.1% to 0.7% per visit), cessation exponentially increased (10.0% to 17.1%), and relapse linearly decreased (21.3% to 11.8%). Non-injecting cocaine use (mainly pre-cooked, comparable to crack) and heroin use strongly increased. Trends were not attributable to changes in the study sample. Harm reduction, including large scale needle exchange programmes, does not lead to an increase in injecting drug use. The injecting decline seems mainly attributable to ecological factors (for example, drug culture and market). Prevention of injecting is possible and peer-based interventions may be effective. The consequences of the recent upsurge in crack use requires further study.

Southeast Indian Ridge Between the Rodriguez Triple Junction and the Amsterdam and Saint-Paul Islands: Detailed Kinematics for the Past 20 m.y.

NASA Astrophysics Data System (ADS)

Royer, Jean-Yves; Schlich, Roland

1988-11-01

The Southeast Indian Ridge has the fastest spreading rates of the three mid-oceanic ridge systems of the Indian Ocean and has recorded the movements of Antarctica relative to Australia and India since the Late Cretaceous. New bathymetric and magnetic data have been collected by the R/V Marion Dufresne (1983) and the R/V Jean Charcot (1984), on the western part of this ridge, between the Rodriguez Triple Junction (25.5°S, 70.0°E) and the Amsterdam and Saint-Paul islands (38°S, 78°E). These data bring additional information on the seafloor magnetic pattern produced by the Southeast Indian Ridge during the past 20 m.y. A new tectonic chart is proposed for the area around the Amsterdam and Saint-Paul islands. We have mapped 17 isochrons ranging from anomalies 6 to 1 (20.5-0.7 Ma) based on the compilation of all the data available in this area (25 cruises). Their distribution clearly shows asymmetric features. Reconstructions at short time intervals show that stage poles of rotation describe oscillatory movements along a direction parallel to the Southeast Indian Ridge axis. Observed changes in spreading rates and the stability of the spreading directions since the Miocene support this result.

[Induced abortion in The Netherlands in the twentieth century; from taboo to revolutionary change].

PubMed

Treffers, P E

2006-03-11

Between 1890 and 1945 the number of induced (criminal) abortions increased in Amsterdam; from 1945 up until the 1960s the number decreased slightly. In 1965 the number of induced abortions that took place in Amsterdam was estimated at more than 2000. Complications were frequent and included infections, septicaemia, damage caused by injected soap and sometimes air embolism. Women in Amsterdam often used primitive methods of contraception, but effective methods, such as condoms and diaphragms, were also used to some degree. Oral contraception was introduced in The Netherlands in 1962. Its use increased rapidly and consequently many doctors were confronted with problems surrounding contraception, including failures and abortion requests. After a television programme on abortion in 1967, requests for abortion surged. Hospitals set up multidisciplinary abortion committees to assess the requests, but soon it became evident that the women themselves were better able to judge whether they should undergo the procedure. Abortion clinics were established outside hospitals. Support from the feminist movement played a role after changes were already underway. The nationwide number of abortions increased to 21,000 in 1972 and to about 25,000 in the 1990s. The number remained stable, even among teenagers, because caregivers placed a great deal of emphasis on adequate contraception.

An early observation on the anatomy of the inguinal canal and the etiology of inguinal hernias by Petrus Camper in the 18th century.

PubMed

IJpma, Frank F A; van de Graaf, Robert C; van Geldere, Dick; van Gulik, Thomas M

2009-06-01

The famous Dutch medical doctor Petrus Camper (1722-1789) was appointed professor of anatomy and surgery at the University of Franeker, Amsterdam, and Groningen. As Praelector Anatomiae of the Amsterdam Guild of Surgeons, he gave public anatomy lessons in the Anatomy theatre in Amsterdam. During the mid 18th century he performed dissections on corpses of children and adults to investigate the anatomy and etiology of inguinal hernias. The concept that a hernia was caused by "a rupture of the peritoneum" was common at that time. Camper concluded that this was incorrect and provided a clear description of the etiology of hernias in children and adults. For the treatment of inguinal hernias, he designed a truss based on the geometrical proportions of the pelvis. This "truss of Camper" was much used and internationally renowned. His anatomical studies and perfect, self-drawn illustrations contributed to a better understanding of the anatomy of the inguinal canal, on the national as well as international level. Camper's "Icones Herniarum" is his most widely known work on inguinal hernias and included a series of outstanding anatomical illustrations. Petrus Camper should be considered one of the pioneers in the field of inguinal hernias.

[Veterinary issues in the proceedings of the Amsterdam Agricultural Society, 1776-1832].

PubMed

Mathijsen, A H H M

2006-01-01

The Amsterdam Agricultural Society, founded in 1776, was created by six wealthy gentlemen, well known for the important positions in society held by them. They invested the money earned through trade among others in the acquisition of land, partially newly reclaimed in the surroundings of Amsterdam. As a consequence of the expansion of the population the profitability of agriculture had increased. The merchants and regents knew how to combine business with pleasure. In the second half of the 17th and the first half of the 18th century, they have built about 500 country estates in the surroundings of Amsterdam. Besides the pleasures of country-life, the owners gained a practical interest in agriculture and animal husbandry. Missing practical knowledge in these fields themselves, they felt the moral obligation to contribute to the general welfare of the society by the promotion of new ideas or experiences gained by others. In the first volume of the Proceedings is stated: 'It is beyond question that chemistry, botany, meteorology and the Ars veterinaria are to be considered as the true fundaments of agricultural knowledge'. Inspired by the ideas of the Enlightenment and, quite in conformity with the spirit of the time, the establishment of a society was thought to be the answer in order to bring agricultural and thus economical reform. The method used was copied from the learned societies. The members proposed subjects for prize competitions and judged the answers sent in. The crowned answers were the main, but not the only, contents of the Society's Proceedings. The paper analyses the membership (the number of ordinary members decreased from 70 at the start to 56; that of honorary members was stable at about 20; further there were a few orrespondents), and quantifies the distribution of articles in the Proceedings, devoted respectively to agricultural, veterinary and zootechnical subjects. In addition, a detailed list with commentary, of the veterinary and zootechnical subjects published between 1778 and 1825 is presented.

Smart Grids for Aquifer Thermal Energy Storage (ATES): a case study for the Amsterdam Zuidas district

NASA Astrophysics Data System (ADS)

Jaxa-Rozen, Marc; Bloemendal, Martin; Rostampour, Vahab

2017-04-01

In the context of increasingly strict requirements for building energy efficiency, Aquifer Thermal Energy Storage (ATES) systems have emerged as an effective means to reduce energy demand for space heating and cooling in larger buildings. In the Netherlands, over 2000 systems are currently active, which has already raised issues with spatial planning in some areas; current planning schemes may lack the flexibility to properly address variations in ATES operation, which are driven by uncertainties across a broad range of time scales - from daily changes in building energy demand, to decadal trends for climate or groundwater conditions. This work is therefore part of a broader research effort on ATES Smart Grids (ATES-SG), which has focused on more adaptive methods for ATES management and control. In particular, improved control schemes which allow for coordination between neighboring ATES systems may offer more robust performance under uncertainty (Rostampour & Keviczky, 2016). The case studies for the ATES-SG project have so far focused on idealized cases, and on a historical simulation of ATES development in the city center of Utrecht. This poster will present an additional case study for the city center of Amsterdam, which poses several geohydrological challenges for ATES: for instance, variable density flow due to salinity gradients in the local aquifer, and varying depths for ATES systems due to the thickness of the aquifer. To study the effect of these conditions, this case uses an existing 15-layer geohydrological model of the Amsterdam region, cropped to an area of 4500m x 2500m around the Amsterdam Zuidas district. This rapidly developing business district is one of the densest areas of ATES use in Amsterdam, with 32 well doublets and 53 monowells currently registered. The geohydrological model is integrated with GIS data to accurately represent ATES spatial planning; simulated well flows are provided by a model predictive control component. This model is then simulated for two cases: a baseline decoupled configuration without coordination, and a case in which a subset of adjacent ATES systems is managed centrally to avoid overlaps between stored thermal volumes. Given that the thickness of the local aquifer offers significant potential for further ATES adoption in the area, such a coordinated approach could help maximize the benefits of future ATES development. References Rostampour, V., & Keviczky, T. (2016). Probabilistic Energy Management for Building Climate Comfort in Smart Thermal Grids with Seasonal Storage Systems. Submitted to IFAC World Congress 2017. Available at https://arxiv.org/abs/1611.03206

Groundwater impacts on surface water quality and nutrient loads in lowland polder catchments: monitoring the greater Amsterdam area

NASA Astrophysics Data System (ADS)

Yu, Liang; Rozemeijer, Joachim; van Breukelen, Boris M.; Ouboter, Maarten; van der Vlugt, Corné; Broers, Hans Peter

2018-01-01

The Amsterdam area, a highly manipulated delta area formed by polders and reclaimed lakes, struggles with high nutrient levels in its surface water system. The polders receive spatially and temporally variable amounts of water and nutrients via surface runoff, groundwater seepage, sewer leakage, and via water inlets from upstream polders. Diffuse anthropogenic sources, such as manure and fertiliser use and atmospheric deposition, add to the water quality problems in the polders. The major nutrient sources and pathways have not yet been clarified due to the complex hydrological system in lowland catchments with both urban and agricultural areas. In this study, the spatial variability of the groundwater seepage impact was identified by exploiting the dense groundwater and surface water monitoring networks in Amsterdam and its surrounding polders. A total of 25 variables (concentrations of total nitrogen (TN), total phosphorus (TP), NH4, NO3, HCO3, SO4, Ca, and Cl in surface water and groundwater, N and P agricultural inputs, seepage rate, elevation, land-use, and soil type) for 144 polders were analysed statistically and interpreted in relation to sources, transport mechanisms, and pathways. The results imply that groundwater is a large source of nutrients in the greater Amsterdam mixed urban-agricultural catchments. The groundwater nutrient concentrations exceeded the surface water environmental quality standards (EQSs) in 93 % of the polders for TP and in 91 % for TN. Groundwater outflow into the polders thus adds to nutrient levels in the surface water. High correlations (R2 up to 0.88) between solutes in groundwater and surface water, together with the close similarities in their spatial patterns, confirmed the large impact of groundwater on surface water chemistry, especially in the polders that have high seepage rates. Our analysis indicates that the elevated nutrient and bicarbonate concentrations in the groundwater seepage originate from the decomposition of organic matter in subsurface sediments coupled to sulfate reduction and possibly methanogenesis. The large loads of nutrient-rich groundwater seepage into the deepest polders indirectly affect surface water quality in the surrounding area, because excess water from the deep polders is pumped out and used to supply water to the surrounding infiltrating polders in dry periods. The study shows the importance of the connection between groundwater and surface water nutrient chemistry in the greater Amsterdam area. We expect that taking account of groundwater-surface water interaction is also important in other subsiding and urbanising deltas around the world, where water is managed intensively in order to enable agricultural productivity and achieve water-sustainable cities.

Usage of purchased self-tests for HIV and sexually transmitted infections in Amsterdam, the Netherlands: results of population-based and serial cross-sectional studies among the general population and sexual risk groups.

PubMed

Bil, Janneke P; Prins, Maria; Stolte, Ineke G; Dijkshoorn, Henriëtte; Heijman, Titia; Snijder, Marieke B; Davidovich, Udi; Zuure, Freke R

2017-09-21

There are limited data on the usage of commercially bought self-tests for HIV and other sexually transmitted infections (STIs). Therefore, we studied HIV/STI self-test usage and its determinants among the general population and sexual risk groups between 2007 and 2015 in Amsterdam, the Netherlands. Data were collected in four different studies among the general population (S1 - 2) and sexual risk groups (S3 - 4). S1 - Amsterdam residents participating in representative population-based surveys (2008 and 2012; n=6044) drawn from the municipality register; S2 - Participants of a population-based study stratified by ethnicity drawn from the municipality register of Amsterdam (2011-2015; n=17 603); S3 - Men having sex with men (MSM) participating in an HIV observational cohort study (2008 and 2013; n=597) and S4 - STI clinic clients participating in a cross-sectional survey (2007-2012; n=5655). Prevalence of HIV/STI self-test usage and its determinants. The prevalence of HIV/STI self-test usage in the preceding 6-12 months varied between 1% and 2% across studies. Chlamydia self-tests were most commonly used, except among MSM in S3. Chlamydia and syphilis self-test usage increased over time among the representative sample of Amsterdam residents (S1) and chlamydia self-test usage increased over time among STI clinic clients (S4). Self-test usage was associated with African Surinamese or Ghanaian ethnic origin (S2), being woman or MSM (S1 and 4) and having had a higher number of sexual partners (S1-2). Among those in the general population who tested for HIV/STI in the preceding 12 months, 5-9% used a self-test. Despite low HIV/STI self-test usage, we observed increases over time in chlamydia and syphilis self-test usage. Furthermore, self-test usage was higher among high-risk individuals in the general population. It is important to continue monitoring self-test usage and informing the public about the unknown quality of available self-tests in the Netherlands and about the pros and cons of self-testing. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

When the spell is broken: gentrification, urban tourism and privileged discontent in the Amsterdam canal district.

PubMed

Pinkster, Fenne M; Boterman, Willem R

2017-07-01

Expansion of urban tourism in historic districts in European cities is putting increasing pressure on these areas as places to live. In Amsterdam, an ever-growing number of tourists visit the famous canal district, which also forms the home of a group of long-term, upper-middle-class residents. While such residents are generally depicted as instigators of urban transformation, in this case, they are on the receiving end. Bringing together the literature on the socio-spatial impact of tourism, belonging and the lived experience of place, this article explores the changing relationship between these established residents and their neighbourhood and provides insight into their growing sense of discontent and even powerlessness in the face of neighbourhood change.

Evaluation of the Digital Alzheimer Center: Testing Usability and Usefulness of an Online Portal for Patients with Dementia and Their Carers.

PubMed

Hattink, Bart; Droes, Rose-Marie; Sikkes, Sietske; Oostra, Ellen; Lemstra, Afina W

2016-07-21

Dementia is a progressive and highly disabling neurodegenerative disease that will likely become highly prevalent in the future due to the globally aging population. To improve health care efficiency and quality for dementia care, eHealth could help with, for example, an online portal, such as the Digital Alzheimer Center (DAC) of the Vrije Universiteit Medical Center Amsterdam. It provides up-to-date disease information, peer-to-peer contact, and methods for contacting the hospital and health professionals. We aimed to investigate the usability and usefulness of the DAC for patients with dementia and carers to get insight into the feasibility and value of this eHealth app in dementia care and to recommend potential improvements. A descriptive study among patients, carers, and health care professionals was performed. Mixed methods were used, consisting of observations (n=10, 4 people with dementia, 6 carers), an online survey (n=287; 88 patients, 199 carers), and semistructured interviews (n=18; 6 patients, 6 carers, 6 health care professionals). During the observations, participants performed a set of five different prescribed tasks on the portal. Speed, number of errors, and navigation were noted. The online survey aimed to assess users' opinions on the portal's usability and usefulness. Semistructured interviews were conducted in a subsample of patients, carers, and health care professionals to gain more in-depth information. In the usability assessment, eight categories of errors were distinguished, of which three were of critical, two of medium, and three of low severity. In the survey, 45% (40/88) of the patients and 53% (105/199) of the carers indicated they used the portal. In all, 33% (12/36) of patients and 61% (62/102) of carers found it easy to learn to work with the portal. Most considered the DAC generally useful: 65% (17/26) of patients and 78% (67/86) of carers found the DAC useful, especially for understanding dementia (patients: 64%, 16/25; carers: 62%, 53/86). In the semistructured interviews, the site was generally rated positively on usability and usefulness and being well designed. People with dementia and carers indicated it helped them to understand and deal with dementia. To our knowledge, this is the first study investigating the usability and usefulness of an Internet portal especially designed for people with dementia and their carers. An online patient portal could be a useful means to help to support patients and carers in dealing with dementia: the majority of users positively evaluated usability and usefulness of the portal, and appreciated the information on it. However, only a minority of patients found it easy to work with the portal. Good design and frequent usability testing is essential to offer a good online portal.

[Lessons learned from the implementation of Dutch national healthcare guidelines on childhood obesity].

PubMed

Schalkwijk, A A H; Nijpels, G; Bot, S D M; Chin A Paw, M J M; Renders, C M; Elders, P J M

2016-01-01

To describe the implementation and feasibility of the national healthcare guidelines on childhood obesity in a region with a high prevalence of overweight and obesity in children. Descriptive, implementation study. The implementation of the guidelines took place in the borough Amsterdam West. In total, 17 general practitioners (GP) from the Academic General Practice Network (ANH) of the VU University Medical Center, Amsterdam, participated in the study, along with 19 child healthcare practitioners and 3 paediatricians. A number of measures were taken to promote implementation. Feasibility was evaluated using both qualitative and quantitative methods. The participating healthcare providers found the training in application of the guidelines and case study discussions useful. GPs found that their role as central caregiver was not feasible. All participants expressed a preference for child healthcare practitioners as the central caregiver. A total of 327 obese children were invited to attend the GP's surgery; only 65 of them participated in the study and only 28 children were monitored for a whole year. Collaboration agreements between involved healthcare providers were rarely fulfilled. Implementation of the national healthcare guidelines on childhood obesity in the current form appears not to be feasible in Amsterdam West, despite the many implementation-enhancing measures that were applied. It is questionable whether the national healthcare guidelines on childhood obesity in its current form can contribute to addressing the societal problem of overweight and obesity in children.

Sources and elemental composition of ambient PM(2.5) in three European cities.

PubMed

Vallius, M; Janssen, N A H; Heinrich, J; Hoek, G; Ruuskanen, J; Cyrys, J; Van Grieken, R; de Hartog, J J; Kreyling, W G; Pekkanen, J

2005-01-20

Source apportionment of urban fine particle mass (PM(2.5)) was performed from data collected during 1998-1999 in Amsterdam (The Netherlands), Erfurt (Germany) and Helsinki (Finland), using principal component analysis (PCA) and multiple linear regression. Six source categories of PM(2.5) were identified in Amsterdam. They were traffic-related particles (30% of the average PM(2.5)), secondary particles (34%), crustal material (7%), oil combustion (11%), industrial and incineration processes (9%), and sea salt (2%). The unidentified PM(2.5) fraction was 7% on the average. In Erfurt, four source categories were extracted with some difficulties in interpretation of source profiles. They were combustion emissions related to traffic (32%), secondary PM (32%), crustal material (21%) and industrial processes (8%). In Erfurt, 3% of PM(2.5) remained unidentified. Air pollution data and source apportionment results from the two Central European cities were compared to previously published results from Helsinki, where about 80% of average PM(2.5) was attributed to transboundary air pollution and particles from traffic and other regional combustion sources. Our results indicate that secondary particles and local combustion processes (mainly traffic) were the most important source categories in all cities; their impact on the average PM(2.5) was almost equal in Amsterdam and Erfurt whereas, in Helsinki, secondary particles made up for as much as half of the total average PM(2.5).

What if every drop of rain that falls on the roofs of Amsterdam is used to make beer?

NASA Astrophysics Data System (ADS)

Hut, Rolf; Lugt, Dorien; Ceccarini, Iacopo; van der Horst, Teije; des Tombe, Bas; Schilperoort, Bart; Hoebe, Joris

2017-04-01

The city of Amsterdam, like many cities in the world, faces the problem that because of our changing climate, rainfall events become more intense. Sewers designed to only flood once every 10 years now flood multiple times a year. In an award winning idea, the aptly named brewery Heavenswater, in dutch: "Hemelswater" decided to raise awareness for the growing urban rainwater drainages problems by brewing a beer using rain collected from their roof in stead of from drinking water. In this "what if" research we study the implications of this idea on a large scale. We look into the consequences for the rainwater drainage, but also wastewater, city planning, health care and last but not least: novel economic opportunities.

When the spell is broken: gentrification, urban tourism and privileged discontent in the Amsterdam canal district

PubMed Central

Pinkster, Fenne M; Boterman, Willem R

2017-01-01

Expansion of urban tourism in historic districts in European cities is putting increasing pressure on these areas as places to live. In Amsterdam, an ever-growing number of tourists visit the famous canal district, which also forms the home of a group of long-term, upper-middle-class residents. While such residents are generally depicted as instigators of urban transformation, in this case, they are on the receiving end. Bringing together the literature on the socio-spatial impact of tourism, belonging and the lived experience of place, this article explores the changing relationship between these established residents and their neighbourhood and provides insight into their growing sense of discontent and even powerlessness in the face of neighbourhood change. PMID:29278248

Hepatitis B vaccination and changes in sexual risk behaviour among men who have sex with men in Amsterdam.

PubMed

Xiridou, M; Wallinga, J; Dukers-Muijers, N; Coutinho, R

2009-04-01

The impact of hepatitis B vaccination in men having sex with men in Amsterdam has been marginal until now, possibly because of increases in sexual risk behaviour counterbalancing the effect of vaccination. A mathematical model is used to describe the hepatitis B epidemic. The model shows that, with the current vaccination coverage, the decrease in incidence is small in the beginning. However, the number of infections prevented per vaccine administered rises over time. Nevertheless, increased risk behaviour reduces the benefit of vaccination. Targeting high-risk men is more successful in reducing and containing the epidemic than targeting low-risk men. In conclusion, the vaccination campaign is effective and should be intensified. High-risk men should be targeted for vaccination and for risk reduction.

vanC Cluster of Vancomycin-Resistant Enterococcus gallinarum BM4174

PubMed Central

Arias, Cesar A.; Courvalin, Patrice; Reynolds, Peter E.

2000-01-01

Glycopeptide-resistant enterococci of the VanC type synthesize UDP-muramyl-pentapeptide[d-Ser] for cell wall assembly and prevent synthesis of peptidoglycan precursors ending in d-Ala. The vanC cluster of Enterococcus gallinarum BM4174 consists of five genes: vanC-1, vanXYC, vanT, vanRC, and vanSC. Three genes are sufficient for resistance: vanC-1 encodes a ligase that synthesizes the dipeptide d-Ala-d-Ser for addition to UDP-MurNAc-tripeptide, vanXYC encodes a d,d-dipeptidase–carboxypeptidase that hydrolyzes d-Ala-d-Ala and removes d-Ala from UDP-MurNAc-pentapeptide[d-Ala], and vanT encodes a membrane-bound serine racemase that provides d-Ser for the synthetic pathway. The three genes are clustered: the start codons of vanXYC and vanT overlap the termination codons of vanC-1 and vanXYC, respectively. Two genes which encode proteins with homology to the VanS-VanR two-component regulatory system were present downstream from the resistance genes. The predicted amino acid sequence of VanRC exhibited 50% identity to VanR and 33% identity to VanRB. VanSC had 40% identity to VanS over a region of 308 amino acids and 24% identity to VanSB over a region of 285 amino acids. All residues with important functions in response regulators and histidine kinases were conserved in VanRC and VanSC, respectively. Induction experiments based on the determination of d,d-carboxypeptidase activity in cytoplasmic extracts confirmed that the genes were expressed constitutively. Using a promoter-probing vector, regions upstream from the resistance and regulatory genes were identified that have promoter activity. PMID:10817725

Development of a Healthy Urban Route Planner for cyclists and pedestrians in Amsterdam

NASA Astrophysics Data System (ADS)

van der Molen, Michiel; Ligtenberg, Arend; Vreugdenhil, Corne; Steeneveld, Gert-Jan

2017-04-01

Cities are hotspots of air pollution and heat stress, the exposure to which results in nuisance, health risks, cost of medication, reduced labour productivity and sick leave for citizens. Yet the air pollution and heat stress are spatially and temporally unevenly distributed over the city, depending on pollutant emissions, street design and atmospheric turbulent mixing and radiation. This spatiotemporal variation allows pedestrians and bikers to choose alternative routes to minimize their exposure, if the distribution is known. In this project, we develop a route planner for bicyclists and pedestrians for Amsterdam (NL), that proposes routes and departure times based on model simulations of weather and air quality. We use the WRF-Chem atmosphere and air quality model at unprecedented grid spacing of 100-m (Ronda et al, 2015, Super et al, 2016), with an underlying urban canopy model and NOx and PM10 emissions. The emissions by traffic are calculated based on observed traffic intensities and emission factors. An urban land use map will characterize urban density and street configuration to estimate urban heat storage (Attema et al, 2015). WRF-Chem runs will be issued daily for a lead time of 48 hours, resulting in forecast maps of temperature and pollutant concentrations that will be uniquely expressed in a metric that combines both threats. The hourly fields of this metric are provided to the route planner based on the open source routing library pgRouting to identify the more healthy routes on the route network of Amsterdam. The objectives of the healthy urban route planner are to raise awareness of heat and air quality issues in Amsterdam, to provide an innovative adaptation tool for citizens and tourists, to locate the most important bottlenecks in (the exposure to) air pollution and heat stress, and ultimately to test the readiness of the travellers to use the information and adapt the route. We expect to particularly target a group of lung- and cardiovascular patients, and elderly people. In the future the planner will be expanded with pollen information and possibly with real-time traffic information.

Outcome of 24 years national surveillance in different hereditary colorectal cancer subgroups leading to more individualised surveillance.

PubMed

Lindberg, Lars Joachim; Ladelund, Steen; Frederiksen, Birgitte Lidegaard; Smith-Hansen, Lars; Bernstein, Inge

2017-05-01

Individuals with hereditary non-polyposis colorectal cancer (HNPCC) have a high risk of colorectal cancer (CRC). The benefits of colonic surveillance in Lynch syndrome and Amsterdam-positive (familial CRC type X familial colorectal cancer type X (FCCTX)) families are clear; only the interval between colonoscopies is debated. The potential benefits for families not fulfilling the Amsterdam criteria are uncertain. The aim of this study was to compare the outcome of colonic surveillance in different hereditary subgroups and to evaluate the surveillance programmes. A prospective, observational study on the outcome of colonic surveillance in different hereditary subgroups based on 24 years of surveillance data from the national Danish HNPCC register. We analysed 13 444 surveillance sessions, including 8768 incidence sessions and 20 450 years of follow-up. CRC was more incident in the Lynch subgroup (2.0%) than in any other subgroup (0.0-0.4%, p<0.0001), but the incidence of advanced adenoma did not differ between the Lynch (3.6%) and non-Lynch (2.3-3.9%, p=0.28) subgroups. Non-Lynch Amsterdam-positive and Amsterdam-negative families were similar in their CRC (0.1-0.4%, p=0.072), advanced adenoma (2.3-3.3%, p=0.32) and simple adenoma (8.4-9.9%, p=0.43) incidence. In moderate-risk families, no CRC and only one advanced adenoma was found. The risk of CRC in Lynch families is considerable, despite biannual surveillance. We suggest less frequent and more individualised surveillance in non-Lynch families. Individuals from families with a strong history of CRC could be offered 5-year surveillance colonoscopies (unless findings at the preceding surveillance session indicate shorter interval) and individuals from moderate-risk families could be handled with the population-based screening programme for CRC after an initial surveillance colonoscopy. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Electrocautery for Precancerous Anal Lesions

Cancer.gov

Results from a randomized clinical trial conducted in Amsterdam suggest that electrocautery is better than topical imiquimod or fluorouracil at treating potentially precancerous anal lesions in HIV-positive men who have sex with men.

Genetics Home Reference: achromatopsia

MedlinePlus

... NW, Roosing S, van Schooneveld MJ, van Lith-Verhoeven JJ, van Moll-Ramirez N, van den Born LI, ... van Schooneveld MJ, Strom TM, van Lith-Verhoeven JJ, Lotery AJ, van Moll-Ramirez N, Leroy BP, ...

Glycopeptide Resistance vanA Operons in Paenibacillus Strains Isolated from Soil

PubMed Central

Guardabassi, Luca; Perichon, Bruno; van Heijenoort, Jean; Blanot, Didier; Courvalin, Patrice

2005-01-01

The sequence and gene organization of the van operons in vancomycin (MIC of >256 μg/ml)- and teicoplanin (MIC of ≥32 μg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the corresponding genes in enterococcal vanA and vanB operons. The vanAPT operon in P. thiaminolyticus PT-2B1 had the same gene organization as that of vanA operons whereas vanAPA in P. apiarius PA-B2B resembled vanB operons due to the presence of vanW upstream from the vanHAX cluster but was closer to vanA operons in sequence. Reference P. apiarius strains NRRL B-4299 and NRRL B-4188 were found to harbor operons indistinguishable from vanAPA by PCR mapping, restriction fragment length polymorphism, and partial sequencing, suggesting that this operon was species specific. As in enterococci, resistance was inducible by glycopeptides and associated with the synthesis of pentadepsipeptide peptidoglycan precursors ending in d-Ala-d-Lac, as demonstrated by d,d-dipeptidase activities, high-pressure liquid chromatography, and mass spectrometry. The precursors differed from those in enterococci by the presence of diaminopimelic acid instead of lysine in the peptide chain. Altogether, the results are compatible with the notion that van operons in soil Paenibacillus strains and in enterococci have evolved from a common ancestor. PMID:16189102

Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.

PubMed

Guardabassi, Luca; Perichon, Bruno; van Heijenoort, Jean; Blanot, Didier; Courvalin, Patrice

2005-10-01

The sequence and gene organization of the van operons in vancomycin (MIC of >256 microg/ml)- and teicoplanin (MIC of > or =32 microg/ml)-resistant Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B isolated from soil were determined. Both operons had regulatory (vanR and vanS), resistance (vanH, vanA, and vanX), and accessory (vanY, vanZ, and vanW) genes homologous to the corresponding genes in enterococcal vanA and vanB operons. The vanA(PT) operon in P. thiaminolyticus PT-2B1 had the same gene organization as that of vanA operons whereas vanA(PA) in P. apiarius PA-B2B resembled vanB operons due to the presence of vanW upstream from the vanHAX cluster but was closer to vanA operons in sequence. Reference P. apiarius strains NRRL B-4299 and NRRL B-4188 were found to harbor operons indistinguishable from vanA(PA) by PCR mapping, restriction fragment length polymorphism, and partial sequencing, suggesting that this operon was species specific. As in enterococci, resistance was inducible by glycopeptides and associated with the synthesis of pentadepsipeptide peptidoglycan precursors ending in D-Ala-D-Lac, as demonstrated by D,D-dipeptidase activities, high-pressure liquid chromatography, and mass spectrometry. The precursors differed from those in enterococci by the presence of diaminopimelic acid instead of lysine in the peptide chain. Altogether, the results are compatible with the notion that van operons in soil Paenibacillus strains and in enterococci have evolved from a common ancestor.

ECCMID 2016: addressing the burden of recurrent Clostridium difficile infections.

PubMed

Eckmann, Christian; Lyon, Sue

2016-10-01

26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 9-12th April 2016, Amsterdam, The Netherlands The European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) is the annual scientific meeting of the European Society of Clinical Microbiology. ECCMID 2016, held in Amsterdam, The Netherlands, was attended by over 11,600 clinical microbiologists and infectious disease physicians from more than 120 countries. The Congress offered an essential opportunity to learn more about the diagnosis, prevention and treatment of healthcare-associated infections, especially those caused by Clostridium difficile. Recurrent C. difficile infections have an especially serious adverse impact on patients, their families and healthcare systems across Europe and around the world, and continue to be a cause for concern among ECCMID delegates and their colleagues responsible for managing vulnerable patients in acute hospitals and other healthcare facilities.

[Legionella outbreak in Amsterdam: a cooling tower as the source].

PubMed

van den Hoek, J A R; IJzerman, E P F; Coutinho, R A

2006-08-19

During the period 6-28 July 2006, 30 confirmed cases of Legionella infection were identified in Amsterdam, 2 of which were fatal. All had a positive urinary antigen test, by which Legionella pneumophila serogroup I could be demonstrated. Consultations between the parties involved in the control of infectious diseases started on July 7th, as soon as it became clear that there was an outbreak. On July 10th it was established that relatively many of these patients lived in the eastern part of the city centre. After a study of the prevailing winds during the past 3 weeks, the search for installations containing water was started. A cooling tower in the town centre was closed on July 11th by way of precaution. During the following week, this tower was proven to be the source of the outbreak.

Population-based study on the seroprevalence of hepatitis A, B, and C virus infection in Amsterdam, 2004.

PubMed

Baaten, G G G; Sonder, G J B; Dukers, N H T M; Coutinho, R A; Van den Hoek, J A R

2007-12-01

In order to enhance screening and preventive strategies, this study investigated the seroprevalence of hepatitis A, B, and C in the general adult urban population and in subgroups. In 2004, sera from 1,364 adult residents of Amsterdam were tested for viral markers. Sociodemographic characteristics were collected using a standardized questionnaire. For hepatitis A, 57.0% was immune. Of first-generation immigrants from Turkey and Morocco, 100% was immune. Of all Western persons and second-generation non-Western immigrants, approximately half was still susceptible. For hepatitis B, 9.9% had antibodies to hepatitis B core antigen (anti-HBc) and 0.4% had hepatitis B surface antigen. Anti-HBc seroprevalences were highest among first-generation immigrants from Surinam, Morocco, and Turkey, and correlated with age at the time of immigration, and among men with a sexual preference for men. Seroprevalence among second-generation immigrants was comparable to Western persons. The seroprevalence of hepatitis C virus antibodies was 0.6%. In conclusion, a country with overall low endemicity for viral hepatitis can show higher endemicity in urban regions, indicating the need for differentiated regional studies and prevention strategies. More prevention efforts in cities like Amsterdam are warranted, particularly for hepatitis A and B among second-generation immigrants, for hepatitis B among men with a sexual preference for men, and for hepatitis C. Active case finding strategies are needed for both hepatitis B and C. (c) Wiley-Liss, Inc.

Quiet Areas and the Need for Quietness in Amsterdam

PubMed Central

Booi, Hester; van den Berg, Frits

2012-01-01

This paper describes the Quiet Places Project in Amsterdam. The purpose of the study was to find out: (1) which public quiet places there are according to Amsterdam residents; (2) what characterizes a quiet place; (3) to what extent do residents want peace and quiet; (4) how do residents realize these needs. The factors determining the need for quietness are presented in a model showing the influence of demographic and socio-economic issues, health status, sensitiveness to noise, daily activities and the noisiness in and around home. Most important of these factors is sensitivity to noise. Elderly and less healthy people are more often sensitive to noise. People who are annoyed by sound from traffic, airplanes and the like show a higher need for quietness. People with a lively household or neighbourhood report lower needs for quietness. Visiting a quiet place and going outside to walk or bike can have a compensating effect on the need for quietness. This suggests that creating quiet places and enhancing possibilities for quiet recreation in urban environments can have a positive effect on the quality of life in the city. Objective noise levels at the quiet places were taken from environmental noise maps. This shows that there may be a preference for low transportation noise levels, but levels up to 60 dB Lday are acceptable. Apparently this depends on a relative quietness or on non-acoustic characteristics of an area: the presence of vegetation and other pleasant stimuli. PMID:22690181

Vaginal and anal human papillomavirus infection and seropositivity among female sex workers in Amsterdam, the Netherlands: Prevalence, concordance and risk factors.

PubMed

Marra, E; Kroone, N; Freriks, E; van Dam, C L; Alberts, C J; Hogewoning, A A; Bruisten, S; van Dijk, A; Kroone, M M; Waterboer, T; Schim van der Loeff, M F

2018-04-01

We studied prevalence, risk factors and concordance of vaginal and anal HPV infection and L1 seropositivity among female sex workers (FSW) in Amsterdam. In 2016, FSW aged ≥18 years having a sexually transmitted infections (STI) consultation were invited to participate. Participation entailed taking vaginal and anal self-swabs. Demographics and sexual behaviour data were collected. HPV DNA was analysed using the SPF10-PCR-DEIA-LiPA25-system-v1. Serum was tested for HPV L1 antibodies using multiplex serology assays. Determinants of vaginal and anal high risk HPV (hrHPV) infection and L1 seropositivity were assessed with logistic regression analyses. We included 304 FSW; median age was 29 years (IQR 25-37). Vaginal and anal hrHPV prevalence were 46% and 55%, respectively. HrHPV L1 seropositivity was 37%. Vaginal-anal hrHPV concordance was strong, but no significant association between vaginal or anal hrHPV infection and seropositivity was found. Having had anal sexual contact was not associated with anal hrHPV infection (P = 0.119). Vaginal and anal hrHPV prevalence is high among FSW in Amsterdam, the Netherlands. Promotion of HPV vaccination, preferably at the beginning of the sex (work) career, may be a useful prevention method against hrHPV infection and disease. Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Diversity of Tn1546 in vanA-positive Enterococcus faecium clinical isolates with VanA, VanB, and VanD phenotypes and susceptibility to vancomycin.

PubMed

Cha, J O; Yoo, J I; Kim, H K; Kim, H S; Yoo, J S; Lee, Y S; Jung, Y H

2013-10-01

To investigate diversity in the vanA cluster in Enterococcus faecium isolates from nontertiary hospitals. We identified 43 vanA-positive Ent. faecium isolates, including two vancomycin-susceptible isolates, from hospitals between 2003 and 2006. Of these isolates, >85% were resistant to ampicillin, erythromycin and ciprofloxacin. The vanA cluster was classified into six types using overlapping PCR, but the prototype transposon Tn1546 was not found. Most vanA-positive vancomycin-resistant Enterococcus (VRE) carried IS1216V and belonged to Type III (58·1%) or Type II (20·9%). vanY, vanZ and IS1216V were observed in the left and right ends of Type III with long-range PCR. IS1216V was also observed within vanS and vanX in the two vancomycin-susceptible isolates and in two vancomycin-resistant isolates. No VRE isolates with VanB and VanD phenotypes contained point mutations in vanS, unlike in previous reports. Sequence types (STs) of all isolates belonged to clonal complex 17, and ST78 was predominant. Insertion sequences, especially IS1216V, cause structural variation in the vanA cluster. We report the first observation of vanY and vanZ at the left end of Tn1546 in clinical isolates. This is the first report of the frequency of vancomycin resistance and diversity of Tn1546 in vanA-positive Ent. faecium isolates from nontertiary hospitals. © 2013 The Society for Applied Microbiology.

OMEGACAM and Gravitational Lensing

NASA Astrophysics Data System (ADS)

Christen, Fabrice Frédéric Thiébaut

2007-04-01

Het proefschrift van Fabrice Christen gaat over de ontwikkeling van nieuwe methoden voor het corrigeren van (digitale) foto's van melkwegstelsels. Met deze methoden kunnen de beelden uit het heelal beter worden geanalyseerd. Het eerste gedeelte is gewijd aan het werk dat bij ESO is uitgevoerd aan de CCD's van de OmegaCAM camera, het enige instrument van de VST. OmegaCAM is een optische groothoekcamera met een beeldveld van een vierkante graad, opgebouwd uit een mozaiek van 8 bij 4 CCD's. Van elk onderdeel moeten alle kenmerken volledig bekend zijn voordat het in het CCD mozaiek geplaatst kan worden. In het tweede deel van dit proefschrift wordt de ontwikkeling van een nieuwe methode voor het corrigeren van de ``point-spread function'' (PSF) en schatten van de ellipticiteit van de melkwegstelsels besproken. De nieuwe techniek wordt getest en vergeleken met een door sterrenkundigen algemeen gebruikte methode in het veld van zwaartekrachtslenzen, de Kaiser, Squire en Broadhurst (KSB) methode. De nieuwe methode, gebaseerd op shapelet ontleding (vergelijkbaar met wavelet ontleding), gaat verder, en is sneller en theoretisch preciezer dan de KSB methode. Door gebruik te maken van de gecorrigeerde ellipticiteit, kunnen we een statistische analyse uitvoeren om er een kosmisch vervormingssignaal uit te halen. De licht vervormde beelden van de melkwegstelsels bewij zen dat de niet-homogene massaverdeling op megaparsec-schaal voornamelijk bestaat uit grote hoeveelheden donkere materie. Verder vergelijken we de schattingen van de ellipticiteit van de shapelet en KSB methode. Bovendien voeren we ook nog een melkwegstelsel-melkwegstelsel lens analyse uit op de 50 VLT Fors1 afbeeldingen en slagen we erin de belangrijkste eigenschappen van de halo's van de stelsels, die zich op een afstand van een- tot tweeduizend megaparsec (1 parsec = 3,26 lichtjaar = 3,085 x 10^16 meter) bevinden, te bepalen door gebruik te maken van twee modellen van melkwegstelselhalo's. Vergeleken met andere overzichtsmetingen vinden we vergelijkbare resultaten.

Beslisbevoegdheden en Verantwoordelijkheden van de Uitgestegen Soldaat. Deel A: Verplaatsen van Beslisbevoegdheden (Authority and Responsibility of the Dismounted Soldier. Part A. Empowering the Dismounted Soldier)

DTIC Science & Technology

2007-04-01

en verantwoordelijkheden van de uitgestegen soldaat Deel A: verplaatsen van beslisbevoegdheden Datumn april 2007 Auteur (s) R. de Bruin ITE. van Bernmel...Admiraal, Bureau SMP Auteur (s) R. de Bruin Program maleider Projectleider I.E. van Bemnmel dr. W.A. Lotens, A.J. van Vliet, A.J. van Vijet TNO Defensie en...Leadership Theory en wordt relevant geacht voor de ontvangers van aanvullende beslisbevoegdheden. 2.1.3 Het oogmerk van de hogere commandant Een ander

A distinctive dual-channel quorum-sensing system operates in Vibrio anguillarum.

PubMed

Croxatto, Antony; Pride, John; Hardman, Andrea; Williams, Paul; Cámara, Miguel; Milton, Debra L

2004-06-01

Many bacterial cells communicate using diffusible signal molecules to monitor cell population density via a process termed quorum sensing. In marine Vibrio species, the Vibrio harveyi-type LuxR protein is a key player in a quorum-sensing phosphorelay cascade, which controls the expression of virulence, symbiotic and survival genes. Previously, we characterized Vibrio anguillarum homologues of LuxR (VanT) and LuxMN (VanMN) and, in this study, we have identified homologues of LuxPQ (VanPQ) and LuxOU (VanOU). In contrast to other Vibrio species, vanT was expressed at low cell density and showed no significant induction as the cell number increased. In addition, although the loss of VanO increased vanT expression, the loss of VanU, unexpectedly, decreased it. Both VanN and VanQ were required for repression of vanT even in a vanU mutant, suggesting an alternative route for VanNQ signal transduction other than via VanU. VanT negatively regulated its own expression by binding and repressing the vanT promoter and by binding and activating the vanOU promoter. The signal relay results in a cellular response as expression of the metalloprotease, empA, was altered similar to that of vanT in all the mutants. Consequently, the V. anguillarum quorum-sensing phosphorelay systems work differently from those of V. harveyi and may be used to limit rather than induce vanT expression.

Dutch Anthropometry for Vehicle Design and Evaluation

DTIC Science & Technology

2008-10-01

middelen Beschrijving van de werkzaamheden Uitgaande van afmetingen van Nederlanders zijn grenswaarden voor negen paspoppen. met vanSrende...vastgesteld voor het jaar 2015 Hierbij is uitgegaan van een Nederlands antropometrisch bestand (NedScan) Resultaten en conclusies Het resultaat is een kort... Nederlands antropometrisch bestand (NedScan) en van lichaamsafmetingen van goedgekeurde K.L rekruten. De grenswaarden omvatten 95% van dat Nederlandse

19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 1 2011-04-01 2011-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international traffic; repair components. (a)(1) Lift vans, cargo vans, shipping tanks, skids, pallets, caul...

Educational Technology in Holland. The Practice of Instruction

ERIC Educational Resources Information Center

Buter, E. M.

1969-01-01

Discusses the impact of programed instruction on the didactic tradition in education Holland and reviews the thinking on educational technology currently being done at the Teachers' Training Institute of the University of Amsterdam. (LS)

Fast Determination of the Element Excitation of an Active Phased Array Antenna

DTIC Science & Technology

1991-03-01

elementenexcitatie te, bepalen: de amplitude en fase van het elektrische ven-e veld moeten gemeten warden in slechts I richting in het verre veld van de ...Page 3 rapport no FEL-91-BO38 titel Een snelle bepaling van de excitatie van de elenienten van cen actieve phased array antenne auteur(s) I. J.G. van...van der Spek Onderzoek uItgevoerd door Ir. J.G. van Hezewijk SAMENVATIING (ONGERUBRICEERD) Het verre veld stralingsdiagram van een actieve phased array

Amino acid substitutions in the VanS sensor of the VanA-type vancomycin-resistant Enterococcus strains result in high-level vancomycin resistance and low-level teicoplanin resistance.

PubMed

Hashimoto, Y; Tanimoto, K; Ozawa, Y; Murata, T; Ike, Y

2000-04-15

The vancomycin-resistant enterococci GV1, GV2 and GV3, which were isolated from droppings from broiler farms in Japan have been characterized as VanA-type VRE, which express high-level vancomycin resistance (256 or 512 microg ml(-1), MIC) and low-level teicoplanin resistance (1 or 2 microg ml(-1), MIC). The vancomycin resistances were encoded on plasmids. The vancomycin resistance conjugative plasmid pMG2 was isolated from the GV2 strain. The VanA determinant of pMG2 showed the same genetic organization as that of the VanA genes encoded on the representative transposon Tn1546, which comprises vanRSHAXYZ. The nucleotide sequences of all the genes, except the gene related to the vanS gene on Tn1546, were completely identical to the genes encoded on Tn1546. Three amino acid substitutions in the N-terminal region of the deduced VanS were detected in the nucleotide sequence of vanS encoded on pMG2. There were also three amino acid substitutions in the vanS gene of the GV1 and GV3 strains in the same positions as in the vanS gene of pMG2. Vancomycin induced the increased teicoplanin resistance in these strains.

Presence of the vancomycin resistance gene cluster vanC1, vanXYc, and vanT in Enterococcus casseliflavus.

PubMed

Hölzel, Christina; Bauer, Johann; Stegherr, Eva-Maria; Schwaiger, Karin

2014-04-01

The three chromosomally located clustered genes vanC1, vanXYc, and vanT confer intrinsic resistance to vancomycin and are used for species identification of Enterococcus gallinarum. In this study, 28 strains belonging to the E. gallinarum/casseliflavus group isolated from cloacal swabs from laying hens were screened for the presence of vanC1. As confirmed by species-specific multiplex PCR, 11 vanC1-positive strains were identified as E. gallinarum. Surprisingly, one yellow pigmented strain, verified as E. casseliflavus by species-specific multiplex PCR, was also vanC1 positive; vanXYc and vanT were additionally detectable in this strain. To our knowledge, this is the first report of vanC1, vanXYc, and vanT in E. casseliflavus. The minimum inhibitory concentration of vancomycin was 4 mg/L. Real-time reverse transcription-PCR revealed that none of the clustered genes was expressed in this strain. Even if the genes seem not to be active, there is a certain risk that they will be transferred to other bacteria where they might be functionally expressed. Therefore, it may be advisable to expand the search for vanC1, vanXYc, and vanT from E. gallinarum to other (enterococcal) species. This study confirms that enterococci live up to their name as being reservoir bacteria and should therefore always be closely monitored.

The Local Group in LCDM - Shapes and masses of dark halos

NASA Astrophysics Data System (ADS)

Vera-Ciro, Carlos Andrés

2013-01-01

In dit proefschrift bestuderen we de eigenschappen van donkere materie halo's in het LCDM paradigma. Het eerste deel richt zich op de vorm van de massadistributie van dergelijke objecten. We hebben gevonden dat de vorm van ge"isoleerde Melkweg-achtige donkere materie halo's significant afwijkt van bolsymmetrie. De lokale omgeving heeft invloed op de halo's en deze worden daarbij sterk be"invloed door de manier waarop massa aangroeit. We hebben ook de structuur en de baanstructuur van de satellieten van dergelijke halo's in detail onderzocht. In het algemeen zijn deze objecten sferischer dan de halo's zelf. Ze vertonen ook duidelijke afdrukken van getijdenwerking in zowel hun geometrische vorm als in de baanstructuur. Daarna gebruiken we het aantal massieve objecten rond de Melkweg om limieten te zetten op de totale massa van de donkere materie halo van de Melkweg. De eigenschappen van de massaverdeling van de Melkweg worden verder onderzocht in het laatste hoofdstuk. Daar maken we gebruik van de Sagittarius sterstroom om de vorm van de galactische potentiaal beter te bepalen. We komen met een nieuw model dat rekening houdt met de galactische schijf en de invloed van satellietstelsels en die bovendien consistent is met het LCDM paradigma.

Co-colonization of vanA and vanB Enterococcus faecium of clonal complex 17 in a patient with bacteremia due to vanA E. faecium.

PubMed

Seol, Chang Ahn; Park, Jeong Su; Sung, Heungsup; Kim, Mi-Na

2014-06-01

A 53-year-old Vietnamese man with liver cirrhosis was transferred from a Vietnamese hospital to our tertiary care hospital in Korea in order to undergo a liver transplantation. Bacteremia due to vanA Enterococcus faecium was diagnosed, and stool surveillance cultures for vancomycin-resistant enterococci (VRE) were positive for both vanA and vanB E. faecium. Pulsed-field gel electrophoresis analysis revealed that the 2 vanA VRE isolates from the blood and stool were clonal, but the vanB VRE was unrelated to the vanA VRE. vanA and vanB VRE were ST64 and ST18, single-allele variations of clonal complex 17, respectively. This is the first case report of vanA VRE bacteremia in a Vietnamese patient and demonstrates the reemergence of vanB VRE since a single outbreak occurred 15years ago in Korea. The reemergence of vanB VRE emphasizes the importance of VRE genotyping to prevent the spread of new VRE strains. Copyright © 2014 Elsevier Inc. All rights reserved.

Astrobiology Results from ILEWG EuroMoonMars Analogue Field Research

NASA Astrophysics Data System (ADS)

Foing, Bernard H.

We give an update on the astrobiology results from a series of field research campaigns (ILEWG EuroMoonMars) in the extreme environment of the Utah desert. These are relevant to prepare future lunar landers and polar sample return missions, interpret Moon-Mars data (eg SMART1, LRO, Mars Express, MRO, MER, MSL), study habitability and astrobiology in Moon-Mars environments, or to test human-robotic surface EVA or base operations. In the frame of ILEWG EuroMoonMars campaigns (2009 to 2013) we deployed at Mars Desert Research station near Hanksville Utah, a suite of instruments and techniques [0, 1, 2, 9-11] including sample collection, context imaging from re-mote to local and microscale, drilling, spectrometers and life sensors. We analyzed how geological and geo-chemical evolution affected local parameters (mineralogy, organics content, environment variations) and the habitability and signature of organics and biota. Results: Among the important findings are the diversity in the composition of soil samples even when collected in close proximity, the low abundances of detectable PAHs and amino acids and the presence of biota of all three domains of life with significant heterogeneity. An extraordinary variety of putative extremophiles was observed [3,4,9]. A dominant factor seems to be soil porosity and lower clay-sized particle content [6-8]. A protocol was developed for sterile sampling, contamination issues, and the diagnostics of biodiversity via PCR and DGGE analysis in soils and rocks samples [10, 11]. We compare the 2009 campaign results [0-9] to new measurements from 2010-2013 campaigns relevant to: comparison between remote sensing and in-situ measurements; the study of minerals; the detection of organics and signs of life. We acknowledge team members and supporting institutes: B.H. Foing (1, 2, 6), C. Stoker (3), P. Ehrenfreund (4, 5), I. Rammos (2), L. Rodrigues (2), A. Svendsen (2), D. Oltheten (2), I. Schlacht (2), K. Nebergall (6), M. Battler (6, 7), H. v’t Houd (8), A. Bruneau (6,9), M. Cross (6,7), V. Maivald (10), C. Orgel (6), A. Elsaesser (4), S.O.L. Direito (2,4), W.F.M. Röling (2), G.R. Davies (2); EuroGeoMars2009 Team, DOMMEX-ILEWG EuroMoonMars 2010-2013 Teams (1) ESA/ ESTEC, Postbus 299, 2200 AG Noordwik, NL; (2) Vrije Universiteit, Amsterdam, Faculty of Earth & Life Sciences, De Boelelaan 1085, 1081 HV Amsterdam, NL; (3) NASA Ames Research Centre; US; (4) Leiden Institute of Chemistry, NL; (5) Space Policy Institute, GWU, Washington D.C., USA; (6) ILEWG; (7) CPSX; (8) Cerberus Blackshore, ESIC Noordwijk, NL; (9) ENSC Bordeaux; (10) DLR, Bremen References: Foing, Stoker & Ehrenfreund (Editors, 2011) “Astrobiology field Research in Moon/Mars Analogue Environments”, Special Issue of International Journal of Astrobiology , IJA 2011, 10, vol.3. 137-305; [1] Foing B. et al. (2011) Field astrobiology research at Moon-Mars analogue site: Instruments and methods, IJA 2011, 10 (3), 141; [2] Clarke, J., Stoker, C. Concretions in exhumed & inverte channels near Hanksville Utah: implications for Mars, (IJA 2011, 10 (3), 162; [3] Thiel et al., (2011) PCR-based analysis of microbial communities during the EuroGeoMars campaign at Mars Desert Research Station, Utah. (IJA 2011, 10 (3), 177; [4] Direito et al. (2011). A wide variety of putative extremophiles and large beta-diversity at the Mars Desert Research Station (Utah). (IJA 2011, 10 (3), 191; [5] Orzechowska, G. et al (20110 analysis of Mars Analog soils using solid Phase Microextraction, Organics solvent extraction and GCMS, (IJA 2011, 10 (3), 209; [6] Kotler et al. (2011). Analysis of mineral matrices of planetary soils analogs from the Utah Desert. (IJA 2011, 10 (3), 221; [7] Martins et al. (2011). Extraction of amino acids from soils close to the Mars Desert Research Station (MDRS), Utah. (IJA 2011, 10 (3), 231; [8] Ehrenfreund et al. (2011) Astrobiology and habitability studies in preparation for future Mars missions: trends from investigating minerals, organics and biota. (IJA 2011, 10 (3), 239; [9] Stoker C. et al (2011) Mineralogical, Chemical, Organic & Microbial Properties of Subsurface Soil Cores from Mars Desert Research Station, a Phyllosilicate and Sulfate Rich Mars Analog Site, IJA 2011, 10 (3), 269; [10-11] Rodrigues L. et al (2014, in preparation)

Biochemical and Genetic Characterization of the vanC-2 Vancomycin Resistance Gene Cluster of Enterococcus casseliflavus ATCC 25788

PubMed Central

Dutta, Ireena; Reynolds, Peter E.

2002-01-01

The vanC-2 cluster of Enterococcus casseliflavus ATCC 25788 consisted of five genes (vanC-2, vanXYC-2, vanTC-2, vanRC-2, and vanSC-2) and shared the same organization as the vanC cluster of E. gallinarum BM4174. The proteins encoded by these genes displayed a high degree of amino acid identity to the proteins encoded within the vanC gene cluster. The putative d,d-dipeptidase-d,d-carboxypeptidase, VanXYC-2, exhibited 81% amino acid identity to VanXYC, and VanTC-2 displayed 65% amino acid identity to the serine racemase, VanT. VanRC-2 and VanSC-2 displayed high degrees of identity to VanRC and VanSC, respectively, and contained the conserved residues identified as important to their function as a response regulator and histidine kinase, respectively. Resistance to vancomycin was expressed inducibly in E. casseliflavus ATCC 25788 and required an extended period of induction. Analysis of peptidoglycan precursors revealed that UDP-N-acetylmuramyl-l-Ala-δ-d-Glu-l-Lys-d-Ala-d-Ser could not be detected until several hours after the addition of vancomycin, and its appearance coincided with the resumption of growth. The introduction of additional copies of the vanTC-2 gene, encoding a putative serine racemase, and the presence of supplementary d-serine in the growth medium both significantly reduced the period before growth resumed after addition of vancomycin. This suggested that the availability of d-serine plays an important role in the induction process. PMID:12234834

Climate change mitigation by recovery of energy from the water cycle: a new challenge for water management.

PubMed

van der Hoek, J P

2012-01-01

Waternet is responsible for drinking water treatment and distribution, wastewater collection and treatment, and surface water management and control (quality and quantity) in and around Amsterdam. Waternet has the ambition to operate climate neutral in 2020. To realise this ambition, measures are required to compensate for the emission of 53,000 ton CO(2)-eq/year. Energy recovery from the water cycle looks very promising. First, calculations reveal that energy recovery from the water cycle in and around Amsterdam may contribute to a total reduction in greenhouse gas emissions up to 148,000 ton CO(2)-eq/year. The challenge for the coming years is to choose combinations of all the possibilities to fulfil the energy demand as much as possible. Only then the use of fossil fuel can be minimized and inevitable greenhouse gas emissions can be compensated, supporting the target to operate climate neutral in 2020.

Epithelial dysplasia in oral lichen planus. A preliminary report of a Dutch-Hungarian study of 100 cases.

PubMed

De Jong, W F; Albrecht, M; Bánóczy, J; van der Waal, I

1984-06-01

In a combined study of the Free University, Amsterdam and the Semmelweis Medical University, Budapest, the presence of epithelial dysplasia was studied in 100 cases of oral lichen planus. The criteria of epithelial dysplasia which were used in this study correspond with those reported by the WHO Collaborating Centre for Oral Precancerous Lesions in 1978. In approximately 25% of all cases, moderate or at least mild dysplasia was observed. The number of dysplastic changes per section did not show any significant correlation with the clinical type, nor with age or sex. There were no marked differences between the Amsterdam and Budapest material. Long-term data on the follow-up were not available yet. No comment can therefore be given about the meaning of the finding of epithelial dysplasia in lichen planus being a sign of premalignancy or not.

Characterisation of the selective binding of antibiotics vancomycin and teicoplanin by the VanS receptor regulating type A vancomycin resistance in the enterococci.

PubMed

Hughes, C S; Longo, E; Phillips-Jones, M K; Hussain, R

2017-08-01

A-type resistance towards "last-line" glycopeptide antibiotic vancomycin in the leading hospital acquired infectious agent, the enterococci, is the most common in the UK. Resistance is regulated by the VanR A S A two-component system, comprising the histidine sensor kinase VanS A and the partner response regulator VanR A . The nature of the activating ligand for VanS A has not been identified, therefore this work sought to identify and characterise ligand(s) for VanS A . In vitro approaches were used to screen the structural and activity effects of a range of potential ligands with purified VanS A protein. Of the screened ligands (glycopeptide antibiotics vancomycin and teicoplanin, and peptidoglycan components N-acetylmuramic acid, D-Ala-D-Ala and Ala-D-y-Glu-Lys-D-Ala-D-Ala) only glycopeptide antibiotics vancomycin and teicoplanin were found to bind VanS A with different affinities (vancomycin 70μM; teicoplanin 30 and 170μM), and were proposed to bind via exposed aromatic residues tryptophan and tyrosine. Furthermore, binding of the antibiotics induced quicker, longer-lived phosphorylation states for VanS A , proposing them as activators of type A vancomycin resistance in the enterococci. Copyright © 2017 Diamond Light Source Ltd. Published by Elsevier B.V. All rights reserved.

Members of the Genera Paenibacillus and Rhodococcus Harbor Genes Homologous to Enterococcal Glycopeptide Resistance Genes vanA and vanB

PubMed Central

Guardabassi, L.; Christensen, H.; Hasman, H.; Dalsgaard, A.

2004-01-01

Genes homologous to enterococcal glycopeptide resistance genes vanA and vanB were found in glycopeptide-resistant Paenibacillus and Rhodococcus strains from soil. The putative d-Ala:d-Lac ligase genes in Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B were closely related to vanA (92 and 87%) and flanked by genes homologous to vanH and vanX in vanA operons. PMID:15561881

Members of the genera Paenibacillus and Rhodococcus harbor genes homologous to enterococcal glycopeptide resistance genes vanA and vanB.

PubMed

Guardabassi, L; Christensen, H; Hasman, H; Dalsgaard, A

2004-12-01

Genes homologous to enterococcal glycopeptide resistance genes vanA and vanB were found in glycopeptide-resistant Paenibacillus and Rhodococcus strains from soil. The putative D-Ala:D-Lac ligase genes in Paenibacillus thiaminolyticus PT-2B1 and Paenibacillus apiarius PA-B2B were closely related to vanA (92 and 87%) and flanked by genes homologous to vanH and vanX in vanA operons.

Biochemical and genetic characterization of the vanC-2 vancomycin resistance gene cluster of Enterococcus casseliflavus ATCC 25788.

PubMed

Dutta, Ireena; Reynolds, Peter E

2002-10-01

The vanC-2 cluster of Enterococcus casseliflavus ATCC 25788 consisted of five genes (vanC-2, vanXY(C-2), vanT(C-2), vanR(C-2), and vanS(C-2)) and shared the same organization as the vanC cluster of E. gallinarum BM4174. The proteins encoded by these genes displayed a high degree of amino acid identity to the proteins encoded within the vanC gene cluster. The putative D,D-dipeptidase-D,D-carboxypeptidase, VanXY(C-2), exhibited 81% amino acid identity to VanXY(C), and VanT(C-2) displayed 65% amino acid identity to the serine racemase, VanT. VanR(C-2) and VanS(C-2) displayed high degrees of identity to VanR(C) and VanS(C), respectively, and contained the conserved residues identified as important to their function as a response regulator and histidine kinase, respectively. Resistance to vancomycin was expressed inducibly in E. casseliflavus ATCC 25788 and required an extended period of induction. Analysis of peptidoglycan precursors revealed that UDP-N-acetylmuramyl-L-Ala-delta-D-Glu-L-Lys-D-Ala-D-Ser could not be detected until several hours after the addition of vancomycin, and its appearance coincided with the resumption of growth. The introduction of additional copies of the vanT(C-2) gene, encoding a putative serine racemase, and the presence of supplementary D-serine in the growth medium both significantly reduced the period before growth resumed after addition of vancomycin. This suggested that the availability of D-serine plays an important role in the induction process.

EDITORIAL: Special Issue: CAMOP MOLEC XV

NASA Astrophysics Data System (ADS)

2006-01-01

The advances in recent years in the field of molecular dynamics are numerous and impressive. In sophisticated experimental and theoretical studies it is nowadays possible to steer chemical reactions with quantum-number-prepared molecules, to study reaction products fully state-specifically, and to derive accurate potential energy surfaces with the goal of determining the pathways along which molecular interaction can take place. Both experimental and theoretical techniques have rapidly improved, and our understanding of the dynamical nature of chemical processes is continuously growing. In this special issue of CAMOP/Physica Scripta we have tried to present a snapshot of the state-of-the-art in the field of molecular dynamics. It contains a collection of papers submitted in association with the most recent MOLEC meeting (MOLEC XV) held in September 2004 in Nunspeet, The Netherlands. This biannual meeting started in 1976 in Trento and was subsequently organized in Brandbjerg Højskole (Denmark, 1978), Oxford (UK, 1980), Nijmegen (The Netherlands, 1982), Jerusalem (Israel, 1984), Aussois (France, 1986), Assissi (Italy, 1988), Bernkastel-Kues (Germany, 1990), Prague (Czech Republic, 1992), Salamanca (Spain, 1994), Nyborg Strand (Denmark, 1996), Bristol (UK, 1998), Jerusalem (Israel, 2000) and Istanbul (Turkey, 2002). Within the philosophy of CAMOP we have asked invited speakers to report on outstanding problems in their particular field. This comprises discussion of open questions, important applications, new theoretical and experimental approaches and also predictions of future developments. A good comment, in addition to being an authoritative contribution of an acknowledged expert, should also be readable by the non-expert and we have taken special care that the work presented here is introduced in an understandable way and has been placed within the context of accessible literature for the interested reader. The sequence of 16 papers that is presented in this issue is arranged according to three main topics that form a focus within the field and can be roughly summarized as induced chemical (intermolecular) dynamics, molecular spectroscopy/theory, and photo-induced uni-molecular (intramolecular) dynamics. The issue opens with a contribution by the MOLEC XV award winner Levine and his co-workers (the paper by Kornweitz et al) in which they speculate on the possibility of probing electronic rearrangement in a chemical collision using light emitted during the very collision. Banares and co-workers continue with an overview on what is and what is not understood about the dynamics of the `most simple reaction' H + H2 and prospects for future research of this prototypic system are presented. The effect of molecular structure on chemical dynamics is discussed by Pearce \\etal on the example of HCl originating from Cl atoms reacting with different organic ethers. Stereodynamical effects are discussed by Cappelletti and co-workers starting from collisional alignment in supersonic seeded molecular beams with applications ranging from (in)elastic events to selective surface scattering experiments. A laboratory controlled study of chemical reactions under interstellar conditions using temperature variable multi-electrode traps is reviewed by Gerlich and Smith. Eritt \\etal discuss a technique capable of studying the interaction of electrons with size selected molecular ions and results are presented for the electron detachment of Cn- and Aln-clusters. Ultrafast dynamical events at a conical intersection are discussed in a theoretical study by Burghardt et al and the experimental tools to study electron dynamics are presented by Vrakking in a contribution on direct and indirect methods to generate attoseconds. In four spectroscopic and theoretical contributions the latest findings are presented in interpreting and understanding complicated molecular spectra. Meerts and Smit introduce a powerful numerical assign and analysis method based upon genetic algorithms and its performance is demonstrated on the example of dense spectra of (complexed) aromatic species. Interaction potential surface calculations of rare gasses with halogens in van der Waals complexes are described by Delgado-Barrio and co-workers, and Tennyson discusses new theoretical techniques based on the use of the variational principle to guide the spectral assignment of complicated water spectra, e.g. at very high temperatures. Finally, Okumura and co-workers present NIR spectra of NO3 and in combination with new calculations these shed light on how to interpret vibronic couplings in this interesting system. The last section of this issue comprises fragmentation and photo-dissociation studies. Rubio-Lago et al discuss methods to produce high-density spin polarized hydrogen following photodissociation experiments. The photodissociation of HCl and Cl2 is taken as an example by Balint-Kurti et al to demonstrate how amplitudes and phases of the photofragmentation matrix elements are derived from experimental measurements. Directional dynamics in photodissociation processes and the derivation of molecular frame properties are discussed in detail by Van den Brom et al using laboratory oriented molecules. And the issue closes with a contribution by Chambreau et al on different reaction mechanisms in the photodissociation of formaldehyde into H2 and CO. Coming to the end of this editorial, we wish to thank all the authors who participated with their contributions in this issue. It shows what is possible nowadays in the field of molecular dynamics and where things are heading in the near future. We thank Physica Scripta for providing us with the platform for this Special Issue, and we wish you, dear reader, many new insights! Steven Solte, Vrije Universiteit Amsterdam, The Netherlands Harold Linnartz, Leiden Observatory, The Netherlands

New hospital-based policy for children whose parents present at the ER due to domestic violence, substance abuse and/or a suicide attempt.

PubMed

Hoytema van Konijnenburg, Eva M M; Sieswerda-Hoogendoorn, Tessa; Brilleslijper-Kater, Sonja N; van der Lee, Johanna H; Teeuw, Arianne H

2013-02-01

Child maltreatment is a major social problem with many adverse consequences, and a substantial number of maltreated children are not identified by health care professionals. In 2010, in order to improve the identification of maltreated children in hospitals, a new hospital-based policy was developed in Amsterdam, The Netherlands. This policy was adapted from another policy that was developed in The Hague, the Netherlands, in 2007. In the new Amsterdam policy, all adults presenting at the emergency department due to domestic violence, substance abuse, and/or a suicide attempt are asked whether they have any children in their care. If this is the case, parents are urged to visit the outpatient pediatric department together with all of their children. During this visit, problems are evaluated and voluntary referrals can be arranged to different care organizations. If parents refuse to cooperate, their children are reported to the Dutch Child Abuse Counseling and Reporting Centre. The two aims of this study are to describe (1) characteristics of the identified families and (2) the referrals made to different voluntary and involuntary care organizations during the first 2 years after implementation of the policy. Data were collected from medical records. One hundred and six children from 60 households were included, of which 68 children because their mother was a victim of domestic violence. Referrals to care organizations were arranged for 99 children, of which 67 on a voluntary basis. The Amsterdam policy seems successful in arranging voluntary support for the majority of identified children.

Adherence to guidelines for the treatment of Behçet's syndrome in New York and Amsterdam.

PubMed

Kerstens, Floor G; Turkstra, Franktien; Atalay, Selma; van Vugt, Richard M; Swearingen, Christopher J; Yazici, Yusuf

2017-01-01

To assess adherence to published guidelines for the treatment of Behçet's syndrome (BS) in two geographic areas. We extracted guideline statements from the 2008 EULAR recommendations. Adherence to these statements was evaluated retrospectively in both New York (USA) and Amsterdam (The Netherlands), by reviewing records from patients fulfilling the ISG criteria. We analysed data per statement and event, and divided data according to the year in which an event occurred. We compared events prior to 2009 to those after publication of the EULAR recommendations (2009 and later). 474 patients were evaluated, 24 of whom were from Amsterdam. Treatment adherence varied substantially across various Behçet's manifestations, ranging from 21% vs. 31% in posterior uveitis, 50% vs. 25% in arterial disease, 29% vs. 29% in arthritis and 38% vs. 55% in erythema nodosum to 65% vs. 67% in deep venous thrombosis (DVT), before and after publication of the guidelines respectively. Topical treatment of mucocutaneous disease was only 2% vs. 8%, whereas adherence in neuro-Behçet was ≥ 94% and 100% in gastrointestinal disease. Adherence to treatment guidelines varies substantially by Behçet's manifestation. Lack of adherence in manifestations such as eye disease and arthritis suggests that current recommendations are not sufficient or other concurrent manifestations require more aggressive treatment. The extensive use of anti-TNF agents might indicate a shift towards more aggressive treatment. Thus, our results suggest the 2008 guidelines were not in line with treatment in clinical practice over the past years and the recent revision of the recommendations was indeed needed.

Daily variation in fine and ultrafine particulate air pollution and urinary concentrations of lung Clara cell protein CC16

PubMed Central

Timonen, K; Hoek, G; Heinrich, J; Bernard, A; Brunekreef, B; de Hartog, J; Hameri, K; Ibald-Mulli, A; Mirme, A; Peters, A; Tiittanen, P; Kreyling, W; Pekkanen, J

2004-01-01

Background: Daily variations in ambient particulate air pollution have been associated with respiratory mortality and morbidity. Aims: To assess the associations between urinary concentration of lung Clara cell protein CC16, a marker for lung damage, and daily variation in fine and ultrafine particulate air pollution. Methods: Spot urinary samples (n = 1249) were collected biweekly for six months in subjects with coronary heart disease in Amsterdam, Netherlands (n = 37), Erfurt, Germany (n = 47), and Helsinki, Finland (n = 47). Ambient particulate air pollution was monitored at a central site in each city. Results: The mean 24 hour number concentration of ultrafine particles was 17.3x103 cm–3 in Amsterdam, 21.1x103 cm–3 in Erfurt, and 17.0x103 cm–3 in Helsinki. The mean 24 hour PM2.5 concentrations were 20, 23, and 13 µg/m3, respectively. Daily variation in ultrafine particle levels was not associated with CC16. In contrast, CC16 concentration seemed to increase with increasing levels of PM2.5 in Helsinki, especially among subjects with lung disorders. No clear associations were observed in Amsterdam and Erfurt. In Helsinki, the CC16 concentration increased by 20.2% (95% CI 6.9 to 33.5) per 10 µg/m3 increase in PM2.5 concentration (lag 2). The respective pooled effect estimate was 2.1% (95% CI –1.3 to 5.6). Conclusion: The results suggest that exposure to particulate air pollution may lead to increased epithelial barrier permeability in lungs. PMID:15477284

Incidence of Acute Kidney Injury among Patients Treated with Piperacillin-Tazobactam or Meropenem in Combination with Vancomycin.

PubMed

Rutter, W Cliff; Burgess, David S

2018-07-01

Acute kidney injury (AKI) increases during empirical antimicrobial therapy with the combination of piperacillin-tazobactam (TZP) and vancomycin (VAN) compared to the number of incidences with monotherapy or the combination of cefepime and VAN. Limited data regarding the impact of meropenem (MEM) combined with VAN exist. This study examined the AKI incidence among patients treated with MEM plus VAN (MEM+VAN) or TZP+VAN. Data were collected from the University of Kentucky Center for Clinical and Translational Science Enterprise Data Trust from September 2007 through October 2015. Adults without previous renal disease who received MEM+VAN or TZP+VAN for at least 2 days were included. AKI was assessed using risk, injury, failure, loss, and end-stage (RIFLE) criteria. Inverse probability of treatment weighting was utilized to control for differences between groups. In total, 10,236 patients met inclusion criteria, with 9,898 receiving TZP+VAN and 338 receiving MEM+VAN. AKI occurred in 15.4% of MEM+VAN patients and in 27.4% of TZP+VAN patients ( P < 0.001). TZP+VAN was associated with increased AKI compared to the level with MEM+VAN (odds ratio [OR], 2.53; 95% confidence interval [CI], 1.82 to 3.52), after controlling for confounders. Use of MEM+VAN should be considered an appropriate alternative therapy to TZP+VAN if nephrotoxicity is a major concern. The results of this study demonstrate that judicial use of TZP+VAN for empirical coverage of infection is needed. Copyright © 2018 American Society for Microbiology.

Revision of the subfamily Opiinae (Hymenoptera, Braconidae) from Hunan (China), including thirty-six new species and two new genera

PubMed Central

Li, Xi-Ying; van Achterberg, Cornelis; Tan, Ji-Cai

2013-01-01

Abstract The species of the subfamily Opiinae (Hymenoptera: Braconidae) from Hunan (Oriental China) are revised and illustrated. Thirty-six new species are described: Apodesmia bruniclypealis Li & van Achterberg, sp. n., Apodesmia melliclypealis Li & van Achterberg, sp. n., Areotetes albiferus Li & van Achterberg, sp. n., Areotetes carinuliferus Li & van Achterberg, sp. n., Areotetes striatiferus Li & van Achterberg, sp. n., Coleopioides diversinotum Li & van Achterberg, sp. n., Coleopioides postpectalis Li & van Achterberg, sp. n., Fopius dorsopiferus Li, van Achterberg & Tan, sp. n., Indiopius chenae Li & van Achterberg, sp. n., Opiognathus aulaciferus Li & van Achterberg, sp. n., Opiognathus brevibasalis Li & van Achterberg, sp. n., Opius crenuliferus Li & van Achterberg, sp. n., Opius malarator Li, van Achterberg & Tan, sp. n., Opius monilipalpis Li & van Achterberg, sp. n., Opius pachymerus Li & van Achterberg, sp. n., Opius songi Li & van Achterberg, sp. n., Opius youi Li & van Achterberg, sp. n., Opius zengi Li & van Achterberg, sp. n., Phaedrotoma acuticlypeata Li & van Achterberg, sp. n., Phaedrotoma angiclypeata Li & van Achterberg, sp. n., Phaedrotoma antenervalis Li & van Achterberg, sp. n., Phaedrotoma depressiclypealis Li & van Achterberg, sp. n., Phaedrotoma flavisoma Li & van Achterberg, sp. n., Phaedrotoma nigrisoma Li & van Achterberg, sp. n., Phaedrotoma protuberator Li & van Achterberg, sp. n., Phaedrotoma rugulifera Li & van Achterberg, sp. n., Li & van Achterberg,Phaedrotoma striatinota Li & van Achterberg, sp. n., Phaedrotoma vermiculifera Li & van Achterberg, sp. n., Rhogadopsis latipennis Li & van Achterberg, sp. n., Rhogadopsis longicaudifera Li & van Achterberg, sp. n., Rhogadopsis maculosa Li, van Achterberg & Tan, sp. n., Rhogadopsis obliqua Li & van Achterberg, sp. n., Rhogadopsis sculpturator Li & van Achterberg, sp. n., Utetes longicarinatus Li & van Achterberg, sp. n. and Xynobius notauliferus Li & van Achterberg, sp. n. Areotetes van Achterberg & Li, gen. n. (type species: Areotetes carinuliferus sp. n.) and Coleopioides van Achterberg & Li, gen. n. (type species: Coleopioides postpectalis sp. n. are described. All species are illustrated and keyed. In total 30 species of Opiinae are sequenced and the cladograms are presented. Neopius Gahan, 1917, Opiognathus Fischer, 1972, Opiostomus Fischer, 1972, and Rhogadopsis Brèthes, 1913, are treated as a valid genera based on molecular and morphological differences. Opius vittata Chen & Weng, 2005 (not Opius vittatus Ruschka, 1915), Opius ambiguus Weng & Chen, 2005 (not Wesmael, 1835) and Opius mitis Chen & Weng, 2005 (not Fischer, 1963) are primary homonymsandarerenamed into Phaedrotoma depressa Li & van Achterberg, nom. n., Opius cheni Li & van Achterberg, nom. n. andOpius wengi Li & van Achterberg, nom. n., respectively. Phaedrotoma terga (Chen & Weng, 2005) comb. n.,Diachasmimorpha longicaudata (Ashmead, 1905) and Biosteres pavitita Chen & Weng, 2005, are reported new for Hunan, Opiostomus aureliae (Fischer, 1957) comb. n. is new for China and Hunan; Xynobius maculipennis(Enderlein, 1912) comb. n. is new for Hunan and continental China and Rhogadopsis longuria (Chen & Weng, 2005) comb. n. is new for Hunan. The following new combinations are given: Apodesmia puncta (Weng & Chen, 2005) comb. n., Apodesmia tracta (Weng & Chen, 2005) comb. n., Areotetes laevigatus (Weng & Chen, 2005) comb. n., Phaedrotoma dimidia (Chen & Weng, 2005) comb. n., Phaedrotoma improcera (Weng & Chen, 2005) comb. n., Phaedrotoma amputata (Weng & Chen, 2005) comb. n., Phaedrotoma larga (Weng & Chen, 2005) comb. n., Phaedrotoma osculas (Weng & Chen, 2005) comb. n., Phaedrotoma postuma (Chen & Weng, 2005) comb. n., Phaedrotoma rugulosa (Chen & Weng, 2005) comb. n., Phaedrotoma tabularis (Weng & Chen, 2005) comb. n., Rhogadopsis apii (Chen & Weng, 2005) comb. n., Rhogadopsis dimidia (Chen & Weng, 2005) comb. n., Rhogadopsis diutia (Chen & Weng, 2005) comb. n., Rhogadopsis longuria (Chen & Weng, 2005) comb. n., Rhogadopsis pratellae(Weng & Chen, 2005) comb. n., Rhogadopsis pratensis (Weng & Chen, 2005) comb. n., Rhogadopsis sculpta (Chen & Weng, 2005) comb. n., Rhogadopsis sulcifer (Fischer, 1975) comb. n., Rhogadopsis tabidula(Weng & Chen, 2005) comb. n., Xynobius complexus (Weng & Chen, 2005) comb. n., Xynobius indagatrix (Weng & Chen, 2005) comb. n., Xynobius multiarculatus (Chen & Weng, 2005) comb. n. The following (sub)genera are synonymised: Snoflakopius Fischer, 1972, Jucundopius Fischer, 1984, Opiotenes Fischer, 1998, and Oetztalotenes Fischer, 1998, with Opiostomus Fischer, 1971; Xynobiotenes Fischer, 1998, with Xynobius Foerster, 1862; Allotypus Foerster, 1862, Lemnaphilopius Fischer, 1972, Agnopius Fischer, 1982, and Cryptognathopius Fischer, 1984, with Apodesmia Foerster, 1862; Nosopoea Foerster, 1862, Tolbia Cameron, 1907, Brachycentrus Szépligeti, 1907, Baeocentrum Schulz, 1911, Hexaulax Cameron, 1910, Coeloreuteus Roman, 1910, Neodiospilus Szépligeti, 1911, Euopius Fischer, 1967, Gerius Fischer, 1972, Grimnirus Fischer, 1972, Hoenirus Fischer, 1972, Mimirus Fischer, 1972, Gastrosema Fischer, 1972, Merotrachys Fischer, 1972, Phlebosema Fischer, 1972, Neoephedrus Samanta, Tamili, Saha & Raychaudhuri, 1983, Adontopius Fischer, 1984, Kainopaeopius Fischer, 1986, Millenniopius Fischer, 1996, and Neotropopius Fischer, 1999, with Phaedrotoma Foerster, 1862. PMID:23653521

76 FR 68785 - Certain Communications Equipment, Components Thereof, and Products Containing the Same, Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

... complaint names as respondents Cisco Systems, Inc. of San Jose, CA; Cisco Consumer Products LLC of Irvine, CA; Cisco Systems International B.V. of Amsterdam, Netherlands; Cisco-Linksys LLC of Irvine, CA...

Scatterometry

NASA Astrophysics Data System (ADS)

Stoffelen, Adrianus Cornelis Maria

1996-10-01

Een veelheid aan meteorologische metingen is dagelijks beschikbaar. De meeste van deze waarnemingen bevinden zich echter boven land, en met name windwaarnemingen boven de (Noord Atlantische) oceaan zijn schaars. Bij een westelijke luchtstroming is dit een duidelijke beperking voor de weers- en golfverwachtingen ten behoeve van Nederland. Juist dan is het gevaar voor bijvoorbeeld storm of overstroming het grootst. Ook in het aardse klimaatsysteem speelt de wind aan het oppervlak een grote rol en is de belangrijkste factor voor de aandrijving van de oceaancirculatie. De oceaancirculatie op zijn beurt is cruciaal voor de verschijnselen die samenhangen met bijvoorbeeld El Niño. Dit proefschift gaat over het scatterometer instrument dat vanuit de ruimte, zelfs onder een wolkendek, nauwkeurige en betrouwbare informatie geeft over de wind aan het oceaanoppervlak met een hoge mate van ruimtelijke consistentie. Tijdens de tweede wereldoorlog werden radars aan boord van schepen veelvuldig gebruikt voor de opsporing van vijandige vaartuigen. Hierbij werd vastgesteld dat de detectie slechter werd naarmate de wind aan het zeeoppervlak groter was. Proefondervindelijk was hiermee het principe van een wind scatterometer aangetoond. Al snel ontwikkelde zich dan ook de idee de wind aan het zeeoppervlak te meten met behulp van radar. Vanuit een vliegtuig of een satelliet word dan een microgolfbundel onder een schuine hoek naar het zeeoppervlak gestuurd. De microgolfstraling, met gewoonlijk een golflengte van enkele centimeters, wordt verstrooid aan het ruwe oppervlak, en een klein gedeelte van de uitgezonden puls keert terug naar het detectorgedeelte van de scatterometer. Het fysische fenomeen van belang voor de werking van de scatterometer is de aanwezigheid van zogeheten capillaire gavitatiegolven op het zeeoppervlak. Deze golven hebben een golflengte van enkele centimeters en reageren vrijwel instantaan op de sterkte van de wind. De verstrooiing van microgolven is op zijn beurt weer sterk afhankelijk van de amplitude van de capillaire golven. Bovendien blijken de capillaire golfjes over het algemeen gericht in lijn met de windrichting. Aldus bestaat er een verband tussen de hoeveelheid teruggestrooide energie en de windsterkte en -richting op enige hoogte. Een scatterometer instrument wordt zo ontworpen dat uit diverse metingen van het teruggestrooide vermogen, windsterkte en -richting afgeleid kunnen worden. Deze metingen kunnen dan eenvoudig vergeleken worden met bestaande windgegevens van boeien, schepen en weermodellen ter calibratie en validatie.?SAMENVATTING viii Overzicht In de loop der jaren zijn scatterometer instrumenten aan boord van verscheidene satellieten gelanceerd. De scatterometers op de ERS-1 en ERS-2 ("European Remote-sensing Satellite") hebben de langste staat van dienst en zijn sinds 1991 operationeel. Deze scatterometers (die identiek zijn) hebben ieder drie antennes, waarmee het oceaanoppervlak in drie verschillende richtingen bemeten wordt. Een punt op het aardoppervlak wordt eerst door de naar voren gerichte bundel belicht, dan door de naar opzij gerichte bundel, en als laatste door de naar achteren gerichte bundel. De drie metingen, verder kortweg aangeduid als trits, kunnen tegen elkaar worden uitgezet, hetgeen resulteert in een ruimtelijk (3D) plaatje. Door uitgekiende doorsneden te maken van deze ruimte kan de samenhang van de drie metingen kwalitatief worden bestudeerd. De drie metingen blijken dan inderdaad een sterke samenhang te vertonen die verklaard kan worden uit twee geofysische parameters. De drie metingen liggen namelijk in het algemeen dichtbij een hoornvormig (2D) oppervlak. De lengterichting van de hoorn blijkt voornamelijk te corresponderen met een variërende windsterkte (of ruwheid van de zee), en de kortste omtrek van de hoorn met een variërende windrichting (ofwel oriëntatie van de capillaire golfjes). De karakterisatie en modellering van dit oppervlak heeft geleid tot een aanzienlijke verbetering in de interpretatie van de scatterometer, zoals beschreven is in dit proefschrift. Hierboven is een uiterst simplistisch beeld gegeven van de fysica die van belang is bij de interpretatie van de scatterometer. Het eerste hoofdstuk van dit proefschrift beschrijft in meer detail de fysische modellering van belang bij de interpretatie van de scatterometer metingen. Ten eerste, de topografie van het zeeoppervlak is uitermate gecompliceerd en niet nauwkeurig te beschrijven met eenvoudige mathematische vergelijkingen. De capillaire golven hebben een andere fasesnelheid dan de langere golven en beide hebben hiermee een ingewikkelde dynamische interactie. Bij hogere windsnelheid breken de golven en ontstaan er schuimkoppen, hetgeen de fysische beschrijving verder compliceert. Ten tweede, de interactie van een schuin invallende microgolfbundel met dit gecompliceerde oppervlak is evenmin nauwkeurig te beschrijven. Zowel verstrooiing als reflectie kunnen een rol spelen. Ten derde, over de relatie tussen de amplitude van de capillaire golven en de wind op enige hoogte, laten we veronderstellen 10 m, is in de literatuur niet de overeenstemming tot in het gewenste detail. Bij lage windsnelheid zouden de oppervlaktespanning of variaties in de wind variabiliteit een rol kunnen spelen. Gezien de fysische complexiteit, is het niet verwonderlijk dat voor de interpretatie van scatterometer metingen statistische methoden hun opgang gevonden hebben. Dit proefschrift gaat met name in op deze methoden, en geeft, aan de hand van vijf wetenschappelijke publicaties, een tamelijk volledig beeld van de "state-of-the-art", zoals die bereikt is met de?SAMENVATTING ix ERS scatterometers (ERS-1 vanaf 17 juli 1991 en later ERS-2 vanaf 22 november 1995). Het derde hoofdstuk behandelt de visualisatie van de gemeten tritsen in de 3D meetruimte, de bepaling van de spreiding van de metingen rond het hoornvormige oppervlak, en de schatting van de meest waarschijnlijke "werkelijke" (of ruisvrije) trits bij het hoornvormige oppervlak gegeven de metingen en hun nauwkeurigheid (inversie). De perceptie dat de metingen met grote waarschijnlijkheid dichtbij een hoornvormig oppervlak liggen, vormt essentiële a priori informatie van belang voor de inversie. Een inversieprocedure gestoeld op waarschijnlijkheidstheorie is afgeleid. Verder worden aan de hand van de structuur van het hoornvormige oppervlak indicatoren bepaald, van belang voor de kwaliteitscontrole, instrumentbewaking, en de verdere verwerking van de gegevens. In de appendix wordt een methode besproken die beschrijft hoe, aan de hand van geselecteerde windgegevens en een goed wind-microgolf verband, ofwel transfer functie, de scatterometer verstrooiingsmetingen gecalibreerd kunnen worden boven de oceaan. Het blijkt dat deze calibratie, die per antenne wordt uitgevoerd, uiterst nauwkeurig is, en, wanneer toegepast, in de 3D meetruimte de verdeling van gemeten tritsen gemiddeld dichterbij de door de transfer functie gemodelleerde hoorn brengt. Dit levert een verbetert scatterometer wind product op. De methode was met name van groot belang voor de validatie en calibratie van de ERS-2 scatterometer, voordat de instrumentele calibratie was voltooid. Met behulp van een set windgegevens uit een weermodel en hun geschatte nauwkeurigheden, passend in locatie en tijd bij een set van scatterometer metingen en hun geschatte nauwkeurigheden, kan met quasi-lineaire schattingstheorie ("Maximum Likelihood Estimation") de meest waarschijnlijke wind-microgolf transfer functie worden afgeleid. De niet-lineariteit en onnauwkeurige formulering van de transfer functie, een niet-uniforme verdeling van invoergegevens, en een inaccurate formulering van de geschatte nauwkeurigheid kunnen hier een goed resultaat in de weg staan. Een nieuwe functie, genoemd CMOD4, wordt afgeleid in hoofdstuk IV. Een eerste eis die gesteld wordt aan een transfer functie, is dat het in de 3D meetruimte nauwkeurig bij de gemeten tritsen past. Wanneer de "fit" optimaal is zal het gecombineerde effect van meetonnauwkeurigheid en inversiefout kleiner zijn dan 0.5 m s -1 in de wind vector. CMOD4 blijkt binnen deze fout bij de metingen te passen. Een tweede eis is, dat voor een onafhankelijke gegevensset, het verschil tussen de geïnverteerde scatterometer wind en de bijpassende wind van bijvoorbeeld een weermodel zo klein mogelijk is. In de praktijk blijkt dat deze tweede eis impliciet volgt uit de eerste, maar ook dat de onnauwkeurigheid van de scatterometer wind met name wordt bepaald door de associatie van een locatie op de hoorn met een wind vector. De onnauwkeurigheid in de scatterometer wind kan dan ook goed beschreven worden in het wind domein.?SAMENVATTING x In hoofdstuk V wordt dit laatste verder uitgewerkt, en wordt gestreefd naar een gedetailleerde wind calibratie met behulp van in situ gegevens. Windgegevens bevatten doorgaans een relatief grote onnauwkeurigheid. Het wordt aangetoond dat ijking of regressie van zulke gegevens niet mogelijk is in een vergelijking van twee meetsystemen, tenzij de nauwkeurigheid van één van de twee meetsystemen bekend is. In de praktijk is dit meestal niet zo. Voor deze gevallen wordt een methode voorgesteld die uitgaat van de simultane vergelijking van drie meetsystemen. In dit geval kan zowel de ijking als een foutenmodel voor de drie meetsystemen worden opgelost. Toepassing van de methode laat zien dat de scatterometer wind afgeleid met behulp van CMOD4 ruwweg 5 % te laag is, en de oppervlaktewind van het gebruikte weermodel ongeveer 5 % te hoog. Het hoornvormige oppervlak blijkt te bestaan uit twee nauw samenvallende laagjes. Wanneer de wind een component heeft in de kijkrichting van de middelste microgolfbundel wordt de ene hoorn beschreven, en wanneer de wind een component heeft tegengesteld hieraan, de andere. Uit een trits metingen (met ruis) kan dus in het algemeen niet een unieke windvector worden bepaald. Twee ongeveer tegengestelde oplossingen resulteren. Deze dubbelzinnigheid in de windrichting kan in de praktijk worden opgelost door die oplossing te kiezen die het dichtst bij een korte termijn weervoorspelling ligt. Daarna kunnen eisen worden gesteld aan de ruimtelijke consistentie van het gevonden windvector veld. Zoals beschreven in hoofdstuk V levert zo'n methode de goede oplossing in meer dan 99 % van de gevallen. Zo kan een in het algemeen kwalitatief goed windproduct worden afgeleid uit de ERS scatterometermetingen. In het tweede gedeelte van hoofdstuk V wordt ingegaan op de assimilatie van scatterometergegevens in weermodellen. Voor variationele gegevensassimilatie wordt een methode voorgesteld, waarbij de dubbelzinnige scatterometerwinden worden geassimileerd, en niet direct de terugstrooiingsmetingen. Dit vanwege het feit dat de onzekerheid in de interpretatie van de scatterometer, het best is uit te drukken als een fout in de wind. De projectie van deze fout op de microgolfmetingen is niet-lineair, en daarmee tamelijk moeilijk te verwerken binnen de context van meteorologische variationele gegevensassimilatie. Assimilatie van de dubbelzinnige wind daarentegen is tamelijk recht toe recht aan. De scatterometermetingen leiden tot een duidelijk betere analyse en korte-termijn voorspelling van het windveld boven zee. De bedekking is echter zodanig dat andere windwaarnemingen nog lang een zeer welkome aanvulling zullen zijn. Nieuwe Amerikaanse scatterometers met een grotere bedekking zijn in ontwikkeling (met name QuikSCAT en SeaWinds). Vanwege hun andere geometrie en golflengte is echter eerst ontwikkelwerk nodig om tot een gedegen interpretatie te komen. De in dit proefschrift beschreven methodologie kan een belangrijke rol spelen in de interpretatie van de gegevens van deze scatterometers. De volgende generatie Europese scatterometers (ASCAT genoemd) heeft een?SAMENVATTING xi grote bedekking en de microgolflengte en meetgeometrie van de ERS scatterometers. Hiermee zijn we op termijn verzekerd van een goed scatterometer wind product.?SAMENVATTING xii

A revision of the tribe Planitorini van Achterberg (Hymenoptera, Braconidae, Euphorinae), with description of a new genus from Australia.

PubMed

van Achterberg, Cornelis; Quicke, Donald L J; Boring, C Andrew

2017-01-01

The tribe Planitorini van Achterberg (Hymenoptera: Braconidae: Euphorinae) is revised. One new genus Paramannokeraia gen. n. (type species: P. gibsoni sp. n. ) and five new species from Australia are described and illustrated: Mannokeraia albipalpis van Achterberg, sp. n. , M. nigrita van Achterberg, sp. n. , M. punctata van Achterberg, sp. n. , Paramannokeraia gibsoni van Achterberg & Quicke, sp. n. and P. juliae van Achterberg, sp. n. The tribe Mannokeraiini van Achterberg, 1995, is synonymized with the tribe Planitorini ( syn. n. ).

A revision of the tribe Planitorini van Achterberg (Hymenoptera, Braconidae, Euphorinae), with description of a new genus from Australia

PubMed Central

van Achterberg, Cornelis; Quicke, Donald L.J.; Boring, C. Andrew

2017-01-01

Abstract The tribe Planitorini van Achterberg (Hymenoptera: Braconidae: Euphorinae) is revised. One new genus Paramannokeraia gen. n. (type species: P. gibsoni sp. n.) and five new species from Australia are described and illustrated: Mannokeraia albipalpis van Achterberg, sp. n., M. nigrita van Achterberg, sp. n., M. punctata van Achterberg, sp. n., Paramannokeraia gibsoni van Achterberg & Quicke, sp. n. and P. juliae van Achterberg, sp. n. The tribe Mannokeraiini van Achterberg, 1995, is synonymized with the tribe Planitorini (syn. n.). PMID:29290713

Consequences of the Introduction of Insensitive Munitions on Safety, Collateral Damage and Operations (consequenties van de invoering van mkm-munitie op veiligheid, gevolgschade en (internationaal) opereren

DTIC Science & Technology

2006-06-01

van de werkzaamheden In dit rapport worden de gevolgen van initiatie van munitie door een ongewilde externe stimulus beschouwd aan de hand van reele...operationele scenario’s. Dit wordt vergeleken met de gevolgen in dezelfde scenario’s, waarin gebruik is gemaakt van Minder Kwetsbare Munitie (MKM). Naast...de historie van MKM wordt uitgelegd wat Inleiding of terroristische activiteiten, maar ook door MKM is. Vervolgens worden de gevolgen Munitie en de

Genomic and expression analysis of the vanG-like gene cluster of Clostridium difficile.

PubMed

Peltier, Johann; Courtin, Pascal; El Meouche, Imane; Catel-Ferreira, Manuella; Chapot-Chartier, Marie-Pierre; Lemée, Ludovic; Pons, Jean-Louis

2013-07-01

Primary antibiotic treatment of Clostridium difficile intestinal diseases requires metronidazole or vancomycin therapy. A cluster of genes homologous to enterococcal glycopeptides resistance vanG genes was found in the genome of C. difficile 630, although this strain remains sensitive to vancomycin. This vanG-like gene cluster was found to consist of five ORFs: the regulatory region consisting of vanR and vanS and the effector region consisting of vanG, vanXY and vanT. We found that 57 out of 83 C. difficile strains, representative of the main lineages of the species, harbour this vanG-like cluster. The cluster is expressed as an operon and, when present, is found at the same genomic location in all strains. The vanG, vanXY and vanT homologues in C. difficile 630 are co-transcribed and expressed to a low level throughout the growth phases in the absence of vancomycin. Conversely, the expression of these genes is strongly induced in the presence of subinhibitory concentrations of vancomycin, indicating that the vanG-like operon is functional at the transcriptional level in C. difficile. Hydrophilic interaction liquid chromatography (HILIC-HPLC) and MS analysis of cytoplasmic peptidoglycan precursors of C. difficile 630 grown without vancomycin revealed the exclusive presence of a UDP-MurNAc-pentapeptide with an alanine at the C terminus. UDP-MurNAc-pentapeptide [d-Ala] was also the only peptidoglycan precursor detected in C. difficile grown in the presence of vancomycin, corroborating the lack of vancomycin resistance. Peptidoglycan structures of a vanG-like mutant strain and of a strain lacking the vanG-like cluster did not differ from the C. difficile 630 strain, indicating that the vanG-like cluster also has no impact on cell-wall composition.

Out-of-equilibrium processes in suspensions of oppositely charged colloids: liquid-to-crystal nucleation and gel formation

NASA Astrophysics Data System (ADS)

Sanz, Eduardo

2009-03-01

We study the kinetics of the liquid-to-crystal transformation and of gel formation in colloidal suspensions of oppositely charged particles. We analyse, by means of both computer simulations and experiments, the evolution of a fluid quenched to a state point of the phase diagram where the most stable state is either a homogeneous crystalline solid or a solid phase in contact with a dilute gas. On the one hand, at high temperatures and high packing fractions, close to an ordered-solid/disordered-solid coexistence line, we find that the fluid-to-crystal pathway does not follow the minimum free energy route. On the other hand, a quench to a state point far from the ordered-crystal/disordered-crystal coexistence border is followed by a fluid-to-solid transition through the minimum free energy pathway. At low temperatures and packing fractions we observe that the system undergoes a gas-liquid spinodal decomposition that, at some point, arrests giving rise to a gel-like structure. Both our simulations and experiments suggest that increasing the interaction range favors crystallization over vitrification in gel-like structures. [4pt] In collaboration with Chantal Valeriani, Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands and SUPA, School of Physics, University of Edinburgh, JCMB King's Buildings, Mayfield Road, Edinburgh EH9 3JZ, UK; Teun Vissers, Andrea Fortini, Mirjam E. Leunissen, and Alfons van Blaaderen, Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University; Daan Frenke, FOM Institute for Atomic and Molecular Physics, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands and Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK; and Marjolein Dijkstra, Soft Condensed Matter, Debye Institute for Nanomaterials Science, Utrecht University.

Dermatography (Medical Tattooing) for Scars and Skin Grafts in Head and Neck Patients to Improve Appearance and Quality of Life.

PubMed

Drost, Brigitte H; van de Langenberg, Rick; Manusama, Olivia R; Janssens, A Soe; Sikorska, Karolina; Zuur, C Lot; Klop, Willem M C; Lohuis, Peter J F M

2017-01-01

Dermatography (medical tattooing) is often overlooked as an adjuvant procedure to improve color mismatch in the head and neck area, and its effect on patient satisfaction and quality of life has not been evaluated, to our knowledge. To analyze the effect of dermatography on the subjective perception of the appearance of scars and skin grafts and the quality of life in head and neck patients. Case series of patients undergoing dermatography at the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, between July 1, 2007, and April 1, 2015. Participants were invited to respond to 2 questionnaires measuring their scar or graft appearance and their quality of life before and after dermatography as an adjuvant treatment for benign or malignant head and neck tumors. Use of dermatography. Two questionnaires evaluating a visual analog scale score (range, 0-10) and multiple questions on a 5-point scale focusing on satisfaction with the appearance and the quality of life. Among 76 patients, 56 (74%) were included in the study. The mean (SD) age of the study cohort was 56.5 (16.0) years, and 42 (75%) were female. The mean improvement in scar or skin graft perception on the visual analog scale of the modified Utrecht Questionnaire for Outcome Assessment in Aesthetic Rhinoplasty before and after dermatography was 4 points. On the modified Patient Scar Assessment Questionnaire, uniform improvement of approximately 1 point across 9 questions was observed. The answers to all patient satisfaction and quality-of-life questions on both questionnaires improved significantly after dermatography. Dermatography is an effectual adjuvant procedure to improve the subjective perception of scar and skin graft appearance and the quality of life in head and neck patients. 4.

Spark formation as a moving boundary process

NASA Astrophysics Data System (ADS)

Ebert, Ute

2006-03-01

The growth process of spark channels recently becomes accessible through complementary methods. First, I will review experiments with nanosecond photographic resolution and with fast and well defined power supplies that appropriately resolve the dynamics of electric breakdown [1]. Second, I will discuss the elementary physical processes as well as present computations of spark growth and branching with adaptive grid refinement [2]. These computations resolve three well separated scales of the process that emerge dynamically. Third, this scale separation motivates a hierarchy of models on different length scales. In particular, I will discuss a moving boundary approximation for the ionization fronts that generate the conducting channel. The resulting moving boundary problem shows strong similarities with classical viscous fingering. For viscous fingering, it is known that the simplest model forms unphysical cusps within finite time that are suppressed by a regularizing condition on the moving boundary. For ionization fronts, we derive a new condition on the moving boundary of mixed Dirichlet-Neumann type (φ=ɛnφ) that indeed regularizes all structures investigated so far. In particular, we present compact analytical solutions with regularization, both for uniformly translating shapes and for their linear perturbations [3]. These solutions are so simple that they may acquire a paradigmatic role in the future. Within linear perturbation theory, they explicitly show the convective stabilization of a curved front while planar fronts are linearly unstable against perturbations of arbitrary wave length. [1] T.M.P. Briels, E.M. van Veldhuizen, U. Ebert, TU Eindhoven. [2] C. Montijn, J. Wackers, W. Hundsdorfer, U. Ebert, CWI Amsterdam. [3] B. Meulenbroek, U. Ebert, L. Schäfer, Phys. Rev. Lett. 95, 195004 (2005).

Studies of Accreting Neutron Stars with RXTE Cycle 4 Observations: III: TOO Observations of Atoll Sources

NASA Technical Reports Server (NTRS)

Paciesas, William S.

2002-01-01

NASA Grant NAG 5-9244 provided funds for the research projects 'ASM-Triggered TOO Observations of Kilohertz Oscillations in Five Atoll Sources' and 'Further Measurements of the Kilohertz Oscillations in 4U 1705-44' approved under the Rossi X-ray Timing Explorer (RXTE) Guest Observer Program Cycle 4 and funded under the 1999 NASA Astrophysics Data Program. The principal investigator of the observing time proposals was Dr. E. C. Ford (U. of Amsterdam). The grant was funded for one year beginning 3/15/2000. The original ADP proposal was submitted by Prof. Jan van Paradijs, who passed away in 1999 before the funds were distributed. Prof. Wilham S. Padesas administered the grant during the period of performance. In spite of a wealth of observational data on the kHz QPO in low-mass X-ray binaries (LMXBs), the interpretation of this phenomenon is currently uncertain because the pairs of kHz QPO peaks and the oscillations seen in some Type I X-ray bursts are almost, but not quite, connected by a simple beat frequency relation. Further systematic studies of systems with known QPOs are required in order to better understand the phenomenon. The proposals were intended to contribute to a solution to this confusion by observing the sources as they vary over a wide range of X-ray flux. RXTE target-of-opportunity observations of six transient atoll sources, 4U 0614+09, KS 1732-260, Ser X-1, 4U 1702-42, 4U 1820-30 and 4U 1705-44 were to be performed at various flux levels based on ASM measurements.

Technology Assessment and Policy Analysis

ERIC Educational Resources Information Center

Majone, Giandomenico

1977-01-01

Argues that the application of policy analysis to technology assessment requires the abandonment of stereotyped approaches and a reformulation of analytical paradigms to include consideration of institutional constraints. Available from: Elsevier Scientific Publishing Company, Box 211, Amsterdam, the Netherlands, single copies available.…

Empirical Agility

DTIC Science & Technology

2014-06-01

in World War II. One of its most effective applications is recorded in a very interesting little book entitled Patton’s Air Force ( Spires , 2002...Publishing Company, Amsterdam. 1973. Spires , David N, Patton’s Air Force: Forging a Legendary Air-Ground Team. Smithsonian Institution Press, Washington

Jan Hudde and the Quotient Rule before Newton and Leibniz

ERIC Educational Resources Information Center

Curtin, Daniel J.

2005-01-01

This article describes some of the work of Jan Hudde who anticipated some results of calculus. Prior to a career as a Burgomaster of Amsterdam, Hudde engaged in mathematics. His method of finding maxima and minima is especially interesting.

Evaluation of the Digital Alzheimer Center: Testing Usability and Usefulness of an Online Portal for Patients with Dementia and Their Carers

PubMed Central

Droes, Rose-Marie; Sikkes, Sietske; Oostra, Ellen; Lemstra, Afina W

2016-01-01

Background Dementia is a progressive and highly disabling neurodegenerative disease that will likely become highly prevalent in the future due to the globally aging population. To improve health care efficiency and quality for dementia care, eHealth could help with, for example, an online portal, such as the Digital Alzheimer Center (DAC) of the Vrije Universiteit Medical Center Amsterdam. It provides up-to-date disease information, peer-to-peer contact, and methods for contacting the hospital and health professionals. Objective We aimed to investigate the usability and usefulness of the DAC for patients with dementia and carers to get insight into the feasibility and value of this eHealth app in dementia care and to recommend potential improvements. Methods A descriptive study among patients, carers, and health care professionals was performed. Mixed methods were used, consisting of observations (n=10, 4 people with dementia, 6 carers), an online survey (n=287; 88 patients, 199 carers), and semistructured interviews (n=18; 6 patients, 6 carers, 6 health care professionals). During the observations, participants performed a set of five different prescribed tasks on the portal. Speed, number of errors, and navigation were noted. The online survey aimed to assess users’ opinions on the portal’s usability and usefulness. Semistructured interviews were conducted in a subsample of patients, carers, and health care professionals to gain more in-depth information. Results In the usability assessment, eight categories of errors were distinguished, of which three were of critical, two of medium, and three of low severity. In the survey, 45% (40/88) of the patients and 53% (105/199) of the carers indicated they used the portal. In all, 33% (12/36) of patients and 61% (62/102) of carers found it easy to learn to work with the portal. Most considered the DAC generally useful: 65% (17/26) of patients and 78% (67/86) of carers found the DAC useful, especially for understanding dementia (patients: 64%, 16/25; carers: 62%, 53/86). In the semistructured interviews, the site was generally rated positively on usability and usefulness and being well designed. People with dementia and carers indicated it helped them to understand and deal with dementia. Conclusions To our knowledge, this is the first study investigating the usability and usefulness of an Internet portal especially designed for people with dementia and their carers. An online patient portal could be a useful means to help to support patients and carers in dealing with dementia: the majority of users positively evaluated usability and usefulness of the portal, and appreciated the information on it. However, only a minority of patients found it easy to work with the portal. Good design and frequent usability testing is essential to offer a good online portal. PMID:27444209

Inelastic processes in atomic collisions involving ground state and laser-prepared atoms

NASA Astrophysics Data System (ADS)

Planje, Willem Gilles

1999-11-01

In dit proefschrift worden experimenten beschreven waarbij ionen of atomen met een bepaalde snelheid op een ensemble van doelwitatomen worden gericht. Wanneer twee deeltjes elkaar voldoende genaderd hebben, vindt er wissel- werking plaats waarbij allerlei processen kunnen optreden. Deze processen resulteren in specieke eindproducten. Kennis over de interactie tussen twee botsingspartners wordt verkregen door te bekijken welke eindproducten ontstaan, en in welke mate. Een belangrijke grootheid die van invloed is op mogelijke processen is de onderlinge snelheid van de twee kernen, oftewel de botsingssnelheid. Wanneer de botsingssnelheid voldoende klein is dan kunnen de verschillende reactiemechanismen zowel kwalitatief als kwanti- tatief vaak goed voorspeld worden door het systeem te beschouwen als een kort-stondig molecuul, opgebouwd uit de twee botsende deeltjes. De ver- schillende processen die kunnen optreden worden gekwaliceerd afhankelijk van de vorming van bepaalde eindproducten. Ruwweg de volgende indeling kan gemaakt worden: 1. de interne structuur van de eindproducten zijn identiek aan die van de beginproducten. We spreken dan van een elastische botsing. 2. e en van de deeltjes of beiden worden in een aangeslagen toestand ge- bracht (of ge¨oniseerd). Dit zijn processen waarbij de herschikte elek- tronen zich bij de oorspronkelijke kern bevinden. We spreken dan van excitatie of ionisatie. 3. e en of meerdere elektronen bevinden zich bij de andere kern na de botsing (eventueel in aangeslagen toestand). We spreken dan van elek- tronenoverdracht. In het eerste deel van deze dissertatie worden botsingsexperimenten tussen heliumionen en natriumatomen beschreven waarbij het proces van elek- tronenoverdracht wordt onderzocht. Bij dit mechanisme is het buitenste 117?Samenvatting natriumelektron betrokken. Deze kan relatief gemakkelijk `overspringen' naar het heliumion wanneer deze zich dicht in de buurt van het natrium- atoom bevindt. Het elektron kan hierbij een bepaalde (aangeslagen) toe- stand bezetten. Wij meten de bezetting van de heliumtoestanden die onder uitzending van XUV licht ( ? 58 nm) vervallen naar de heliumgrondtoe- stand. Door de lichtintensiteit te meten onderzoeken we de mate van elek- tronenoverdracht naar een selecte groep van singlet helium`eind'toestanden, namelijk He(1s2p), He(1s3s), He(1s3p) en He(1s3d). In een reactie- vergelijking ziet het mechanisme er als volgt uit: He + (1s) + ( Na(3s) Na(3p) e- -! He + Na + -! He(1s 2 ) +h(58 nm) + Na + Het experiment kent een extra dimensie door het feit dat het, in beginsel bol- symmetrische, natriumatoom een bepaalde ruimtelijk uitlijning kan worden meegegeven. Met behulp van laserlicht van een specieke frequentie en po- larisatie, wordt het buitenste natriumelektron in een aangeslagen p toestand gebracht. Het aanslaan naar deze toestand heeft als gevolg dat het valentie- elektron zich op grotere afstand van zijn kern bevindt dan voorheen. Daar- naast kan, afhankelijk van de gebruikte laserpolarisatie, het buitenste elek- tron zich nu rond de natriumkern bewegen volgens een bepaalde anisotrope verdeling, de bolsymmetrie is doorbroken. De eecten van de excitatie en ruimtelijk verdeling van dit natriumelektron op het proces van elektronen- overdracht zijn onderzocht voor botsingsenergie¨en vari¨erend van 0.5 keV tot 6.0 keV. De metingen laten zien dat het eect van laserexcitatie een bezettingstoe- name van de beschouwde singlet heliumtoestanden betekent, ongeacht de uitlijning van het natrium 3p elektron. Dit is simpelweg te begrijpen uit het feit dat het 3p natrium elektron minder sterk gebonden is en elektro- nenoverdracht makkelijker gaat. Daarnaast is de uitlijning van het aanges- lagen elektron van invloed op de elektronenoverdracht. De resultaten zijn vergeleken met berekeningen van S.E. Nielsen en T.H. Rod [13], die de elek- tronoverdracht beschrijven in een model waarbij het betrokken elektron zich beweegt in bepaalde eectieve potentiaalvelden. De goede overeenkomsten van onze metingen met de berekeningen rechtvaardigen de theoretische be- nadering van Nielsen en Rod. 118?Samenvatting In het tweede gedeelte van het proefschrift worden botsingen beschouwd tussen helium- en neonatomen. Hierbij wordt nu niet gekeken naar bots- ingsproducten die zich manifesteren door bepaald licht uit te zenden, maar een elektron emitteren met een bepaalde energie. Verschillende soorten `eind'producten kunnen elektronen uitzenden, waaronder de negatieve ion- toestanden. Het elektronenspectrum, gemeten voor dit botsingssysteem, vertoont twee pieken die het spectrum domineren bij 16.2 eV en 19.4 eV voor verschillende botsingsenergie¨en tussen de 0.35 keV en 6.0 keV. Deze piekstructuren wijzen op de vorming van de kort-levende, negatieve iontoe- standen Ne-(2p 5 3s 2 ) en He-(1s2s 2 ) ten gevolge van de overdracht van e en elektron: He 0 + Ne 0 -! He-(1s2s 2 ) +Ne + (2p 5 ) 3 10- 14 s -! He 0 (1s 2 ) +Ne + + e- (19.37 eV) He 0 + Ne 0 -! He + (1s) +Ne-(2p 5 3s 2 ) 2:5 10- 13 s -! He + (1s) +Ne 0 (2p 6 ) +e- (16.15 eV) De meetresultaten vertonen een fenomeen waarbij de bezettingen van de negatieve iontoestanden een oscillerend gedrag vertonen als functie van de botsingssnelheid. Dit duidt op interferentie tussen de twee bijna-ontaarde moleculaire toestanden [He- + Ne + ] en[He + + Ne-]. Het is echter zeer op- merkelijk dat deze oscillatie wordt waargenomen in een experiment als deze, waarin de uitgezonden elektronen worden gemeten ongeacht de afbuighoek van het heliumatoom. Dit impliceert een speciek aanslagmechanisme van de moleculaire negatieve iontoestanden. Nader beschouwing van het bots- ingssysteem laat zien dat het instantane molecuul twee overgangen moet ondergaan voordat de negatieve iontoestanden gevormd worden. Als gevolg hiervan is de snelheid waarmee het negatieve en positieve ion uit elkaar be- wegen nagenoeg onafhankelijk van de afbuighoek van het helium projectiel en is oscillatie mogelijk waarneembaar. De wisselwerking tussen de twee beschouwde moleculaire toestanden impliceert gecorreleerde overdracht van twee elektronen: He- + Ne + 2e- ! He + + Ne- Door het quasi-resonante systeem als resonant te beschouwen kan het fenomeen kwalitatief goed verklaard worden. 119?Samenvatting Inhet laatstedeelwordt de bevolkingvanauto¨oniserende natriumtoestanden bekeken in He +=0 + Na botsingen. In tegenstelling tot de voorgaande exper- imenten waarin elektronenoverdracht beschouwd werd, betreft het hier een excitatiemechanisme. De beschouwde `eind'producten, i.e. de auto¨oniserende natriumtoestanden, bestaan in het algemeen kort en gaan over naar een stabiele iontoestand onder uitzending van een elektron met een toestands- karakteristieke kinetische energie. Door de elektronenspectra te meten bij verschillende botsingsenergie¨en, wordt de bezetting van de auto¨oniserende toestanden onderzocht. Ook hier wordt het eect van laserexcitatie en laser- polarisatie van het natriumatoom op de vorming van deze toestanden, en de mate waarin, bekeken. De metingen laten zien dat zowel in He + -Na als in He 0 -Na botsingen de invloed van de ruimtelijk uitlijning van het buitenste natriumelektron op de elektronenspectra nihil is. Dit impliceert dat het betrokken 3p elektron hoofdzakelijk een passieve rol speelt in de vorming van auto¨oniserende toe- standen: het blijft hoofdzakelijk de 3p toestand bezetten als een `toeschouwer' zonder een overgang te maken naar een andere toestand. Dit wordt boven- dien bevestigd door het feit dat wanneer een fractie natriumatomen aange- slagen wordt naar de p toestand dit een even grote reductie betekent van onder meer de populatie van de auto¨oniserende toestand Na(2p 5 3s 2 ). De verwachte grote toename van Na(2p 5 3p 2 ) toestanden, in geval van Na(3p) doelwitten, is niet waargenomen. 120?121?122

The first report of the vanC₁ gene in Enterococcus faecium isolated from a human clinical specimen.

PubMed

Sun, Mingyue; Wang, Yue; Chen, Zhongju; Zhu, Xuhui; Tian, Lei; Sun, Ziyong

2014-09-01

The vanC₁ gene, which is chromosomally located, confers resistance to vancomycin and serves as a species marker for Enterococcus gallinarum. Enterococcus faecium TJ4031 was isolated from a blood culture and harbours the vanC₁gene. Polymerase chain reaction (PCR) assays were performed to detect vanXYc and vanTc genes. Only the vanXYc gene was found in the E. faecium TJ4031 isolate. The minimum inhibitory concentrations of vancomycin and teicoplanin were 2 µg/mL and 1 µg/mL, respectively. Real-time reverse transcription-PCR results revealed that the vanC₁ and vanXYc genes were not expressed. Pulsed-field gel electrophoresis and southern hybridisation results showed that the vanC₁ gene was encoded in the chromosome. E. faecalis isolated from animals has been reported to harbour vanC₁gene. However, this study is the first to report the presence of the vanC₁gene in E. faecium of human origin. Additionally, our research showed the vanC₁gene cannot serve as a species-specific gene of E. gallinarum and that it is able to be transferred between bacteria. Although the resistance marker is not expressed in the strain, our results showed that E. faecium could acquire the vanC₁gene from different species.

Tweede Serie Ergonomietests Lichtgewicht Bommenpakken (Second Series of Ergonomic Tests on Lightweight Bomb Disposal Suits)

DTIC Science & Technology

2007-12-01

warmtebelastingtests vast te stellen en (sit-and-reach, stand-and-reach. abductie referentiewaarden te bepalen door het van de arnen, anteflexie van de armen ...volgende, bewegingbeperkingtests: sit-and-reach, stand-and-reach. abductie van de armen , anteflexie van de armen en beperking van zicht. Bij de sit-and...gebogen op de rand van een tafel en houdt de armen zo ver mogeijk gestrekt naar voren op tafel. Daarbij wordt de afstand vanaf de rand van de tafel tot

Molecular Characterization of Enterococcus faecalis N06-0364 with Low-Level Vancomycin Resistance Harboring a Novel d-Ala-d-Ser Gene Cluster, vanL▿

PubMed Central

Boyd, David A.; Willey, Barbara M.; Fawcett, Darlene; Gillani, Nazira; Mulvey, Michael R.

2008-01-01

Enterococcus faecalis N06-0364, exhibiting a vancomycin MIC of 8 μg/ml, was found to harbor a novel d-Ala-d-Ser gene cluster, designated vanL. The vanL gene cluster was similar in organization to the vanC operon, but the VanT serine racemase was encoded by two separate genes, vanTmL (membrane binding) and vanTrL (racemase). PMID:18458129

19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

Code of Federal Regulations, 2014 CFR

2014-04-01

... for inspection by Customs officials upon reasonable notice. (3) If the container does not exit the U.S... 19 Customs Duties 1 2014-04-01 2014-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of...

19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

Code of Federal Regulations, 2012 CFR

2012-04-01

... for inspection by Customs officials upon reasonable notice. (3) If the container does not exit the U.S... 19 Customs Duties 1 2012-04-01 2012-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of...

19 CFR 10.41a - Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of international...

Code of Federal Regulations, 2013 CFR

2013-04-01

... for inspection by Customs officials upon reasonable notice. (3) If the container does not exit the U.S... 19 Customs Duties 1 2013-04-01 2013-04-01 false Lift vans, cargo vans, shipping tanks, skids... Traffic § 10.41a Lift vans, cargo vans, shipping tanks, skids, pallets, and similar instruments of...

First and Second Order Stokes Generation by SRS in Methane: Influence of Rep-Rate, Beam Quality and Astigmatism (Opwekking van Eerste en Tweede Orde Stokes d.m.v. SRS in Methaan: Invloed van de Pulsfrequentie, de Bundelkwaliteit en Astigmatisme)

DTIC Science & Technology

1992-09-01

omzettings rendementen van circa 75% gehaad bij een ingangs- energie van 280 mJ. De mogelijkheden tot bet halen van een hoger rendement lijken...of rep-rate, beam quality and astigmatism DImi-Thu-B~mO ITA1EiM-tT-h lF I~~ ~~’ IAPR2 8 1993~ I ~Xtbai Uiitdw FJ.M. van Putten J.C. van den Heuvel RJ.L...Influence of rep-rate. beam quality and astigmatism author(s) : F.J.M. van Putten, I.C. van den Heuvel, R.J.L. Lerou institute : TNO Physics and

Hydrodynamics of the VanA-type VanS histidine kinase: an extended solution conformation and first evidence for interactions with vancomycin

PubMed Central

Phillips-Jones, Mary K.; Channell, Guy; Kelsall, Claire J.; Hughes, Charlotte S.; Ashcroft, Alison E.; Patching, Simon G.; Dinu, Vlad; Gillis, Richard B.; Adams, Gary G.; Harding, Stephen E.

2017-01-01

VanA-type resistance to glycopeptide antibiotics in clinical enterococci is regulated by the VanSARA two-component signal transduction system. The nature of the molecular ligand that is recognised by the VanSA sensory component has not hitherto been identified. Here we employ purified, intact and active VanSA membrane protein (henceforth referred to as VanS) in analytical ultracentrifugation experiments to study VanS oligomeric state and conformation in the absence and presence of vancomycin. A combination of sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge (SEDFIT, SEDFIT-MSTAR and MULTISIG analysis) showed that VanS in the absence of the ligand is almost entirely monomeric (molar mass M = 45.7 kDa) in dilute aqueous solution with a trace amount of high molar mass material (M ~ 200 kDa). The sedimentation coefficient s suggests the monomer adopts an extended conformation in aqueous solution with an equivalent aspect ratio of ~(12 ± 2). In the presence of vancomycin over a 33% increase in the sedimentation coefficient is observed with the appearance of additional higher s components, demonstrating an interaction, an observation consistent with our circular dichroism measurements. The two possible causes of this increase in s – either a ligand induced dimerization and/or compaction of the monomer are considered. PMID:28397853

In Vivo Fluorescence Confocal Microscopy to Investigate the Role of RhoC in Inflammatory Breast Cancer

DTIC Science & Technology

2005-04-01

5084. 6. Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P, Fox SB, Harris AL, van MarckEA...cancer. Cancer Res 1999, 59: 5079-5084. 17 14. Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P...Ohira S, Feng Y, Nikaido T, Konishi I: Up- regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab

Mentale Inzetbaarheid van Teams: Ontwikkeling van een Moden van Teamfunctioneren als Module voor SCOPE (Mental Readiness of Teams - Development of a Team Model as Module for SCOPE)

DTIC Science & Technology

2007-04-01

inzetbaarheid van teams: ontwikkeling van een model van teamfunctioneren als module voor SCOPE Datumn april 2007 Auteur (s) R. de B~ruin C’. Vervvijs A.J...Datum april 2007 Programmaleider Projectleider Auteur (s) dr. W.A. Lotens, TNO Defensie en A.]. van Vijet, TNO Defensie en R. de Bruin Veiligheid...Deelnemers verwachten wel, in lijn met de theorie , dat een lage cohesie samenhangt met een lage effectiviteit. Een hoge cohesie, daarentegen, zou

User Manual PIRATE Model, Release Beta 1.0. (Handleiding PIRATE model, versie Beta 1.0)

DTIC Science & Technology

1998-01-01

Beperkingen van PIRATE 40 9 . Conclusies en aanbevelingen 41 10. Referenties 42 11 . Ondertekening 43 TNO-rapport FEL-97-A285 Inleiding Bij maritieme...Inhoud Inleiding 7 1.1 Doel van PIRATE 7 1.2 Werking van PIRATE 8 1.3 Opbouw van de handleiding 8 2. Bediening van PIRATE 9 2.1 Systeemvereisten 10...2.2 Installatie 10 2.3 Bediening van de gebruikersinterface 11 2.4 Gebruiken van de figuren in andere programmes 15 3. Radars, radars in PIRATE

A new informant-based questionnaire for instrumental activities of daily living in dementia.

PubMed

Sikkes, Sietske A M; de Lange-de Klerk, Elly S M; Pijnenburg, Yolande A L; Gillissen, Freek; Romkes, Rolinka; Knol, Dirk L; Uitdehaag, Bernard M J; Scheltens, Philip

2012-11-01

Interference in everyday functioning is part of the diagnostic criteria for dementia. Questionnaires measuring "instrumental activities of daily living" (IADL) are used to measure this interference, but the psychometric quality of these questionnaires is often questioned. In addition, these questionnaires are less suited for early-onset patients. This is problematic, given the high frequency of relatively young patients in memory clinics. In this article, we describe the development and psychometric properties of a new informant-based IADL questionnaire aimed at detecting incipient dementia and appropriate for a broad age range. We defined IADL in consensus with experts and constructed items based on existing items and suggestions from experts and informants. Informants of subjects (n = 206) who visited the Alzheimer Center of the VU University Medical Center completed the questionnaire. Factor structure was investigated using classical exploratory factor analysis and item response theory. We assessed test-retest reliability in 73 informants using weighted κ values. The questionnaire consisted of 75 items and was computerized to enhance ease of administration. Exploratory factor analysis supported a single-factor model, with 48.3% of the variance being explained by the first factor. We removed five items, as they did not fit the model. High internal consistency was demonstrated. Test-retest reliability showed that the majority of items (87.9%) had substantial-to-almost perfect κ values. The Amsterdam IADL Questionnaire (Amsterdam IADL questionnaire is a registered trademark of Alzheimer Center VU University Medical Center, Amsterdam, The Netherlands) is a 70-item informant-based computerized questionnaire aimed at detecting early dementia and early-onset dementia. Initial results show that this questionnaire is a promising new tool. Copyright © 2012 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Relationship between psychosocial stress and hypertension among Ghanaians in Amsterdam, the Netherlands--the GHAIA study.

PubMed

Agyei, Bernard; Nicolaou, Mary; Boateng, Linda; Dijkshoorn, Henriette; van den Born, Bert-Jan; Agyemang, Charles

2014-07-07

Hypertension is highly prevalent among recent sub-Saharan African (SSA) migrants in western countries and some tend to associate their hypertension to psychosocial stress. However data on the relationship between hypertension and psychosocial stress among SSA migrants are rare. We assessed the relationship between psychosocial stress and hypertension among the largest SSA migrant population (Ghanaians) in Amsterdam, the Netherlands. Data were obtained from structured interviews along with medical examination among 212 participants from a cross-sectional study: the GHAIA study in 2010 in Amsterdam. Blood pressure was measured with a validated Oscillometric automated digital blood pressure device. Psychosocial stress was assessed by questionnaires on perceived discrimination, depressive symptoms and financial problems. Binary logistic regression was used to study associations between psychosocial stress and hypertension. The overall prevalence of hypertension was 54.7%. About two thirds of the study population experienced a moderate (31%) or high (36%) level of discrimination. 20.0% of the participants had mild depressive symptoms, whilst 9% had moderate depressive symptoms. The prevalence of financial stress was 34.8%. The psychosocial stresses we assessed were not significantly associated with hypertension: adjusted odds ratios comparing those with low levels and those with high levels were 0.99 (95% CI, 0.47-2.08) for perceived discrimination, 0.81 (95% CI, 0.26-2.49) for depressive symptoms and 0.71 (95% CI, 0.37-1.36) for financial stress, respectively. We did not find evidence for the association between psychosocial stress and hypertension among recent SSA migrants. More efforts are needed to unravel other potential factors that may underlie the high prevalence of hypertension among these populations.

Relationship between psychosocial stress and hypertension among Ghanaians in Amsterdam, the Netherlands – the GHAIA study

PubMed Central

2014-01-01

Background Hypertension is highly prevalent among recent sub-Saharan African (SSA) migrants in western countries and some tend to associate their hypertension to psychosocial stress. However data on the relationship between hypertension and psychosocial stress among SSA migrants are rare. We assessed the relationship between psychosocial stress and hypertension among the largest SSA migrant population (Ghanaians) in Amsterdam, the Netherlands. Methods Data were obtained from structured interviews along with medical examination among 212 participants from a cross-sectional study: the GHAIA study in 2010 in Amsterdam. Blood pressure was measured with a validated Oscillometric automated digital blood pressure device. Psychosocial stress was assessed by questionnaires on perceived discrimination, depressive symptoms and financial problems. Binary logistic regression was used to study associations between psychosocial stress and hypertension. Results The overall prevalence of hypertension was 54.7%. About two thirds of the study population experienced a moderate (31%) or high (36%) level of discrimination. 20.0% of the participants had mild depressive symptoms, whilst 9% had moderate depressive symptoms. The prevalence of financial stress was 34.8%. The psychosocial stresses we assessed were not significantly associated with hypertension: adjusted odds ratios comparing those with low levels and those with high levels were 0.99 (95% CI, 0.47–2.08) for perceived discrimination, 0.81 (95% CI, 0.26–2.49) for depressive symptoms and 0.71 (95% CI, 0.37–1.36) for financial stress, respectively. Conclusion We did not find evidence for the association between psychosocial stress and hypertension among recent SSA migrants. More efforts are needed to unravel other potential factors that may underlie the high prevalence of hypertension among these populations. PMID:25001592

Anorectal and inguinal lymphogranuloma venereum among men who have sex with men in Amsterdam, The Netherlands: trends over time, symptomatology and concurrent infections.

PubMed

de Vrieze, Nynke Hesselina Neeltje; van Rooijen, Martijn; Schim van der Loeff, Maarten Franciscus; de Vries, Henry John C

2013-11-01

To examine lymphogranuloma venereum (LGV) trends over time among men who have sex with men (MSM) visiting the Amsterdam sexually transmitted infection (STI) clinic; to investigate anal LGV symptomatology; and to examine the positivity and characteristics of anorectal and inguinal LGV. We included MSM consultations from whom a swab (from anorectum, bubo or an genital ulcer) was taken for Chlamydia trachomatis (Ct) screening. Anorectal swabs were taken from all MSM who reported receptive anorectal intercourse in the preceding 6 months. Ct positive samples were further tested with a pmpH PCR to identify L-genovars. Patient symptoms, clinical and anoscopic inflammatory signs, and STI co-infections were noted; Gram-stained anorectal mucosal smears were examined. Between January 2005 and June 2012, 48 570 consultations among MSM were conducted. In 3628/35 650 visits, anorectal Ct infections were diagnosed, including 411 anal LGV (1.2%). Moreover, 65/1649 genital ulcer swabs were Ct positive; 10 were inguinal LGV (0.6%) Since January 2011 a significant increase in the positivity of LGV occurred (p<0.0001). 89 (27.2%) anorectal LGV cases were asymptomatic. HIV prevalence among anorectal LGV cases was significantly higher (p=0.008) than among inguinal LGV cases. STI co-morbidity in anorectal LGV cases remained invariably high during the study period. Since January 2011, LGV positivity in MSM consultations in Amsterdam has risen significantly. The great majority comprise anal LGV; inguinal LGV is rare. Anal LGV is asymptomatic in a quarter of cases. In all MSM with anal Ct infections LGV should be excluded, irrespective of symptoms or inflammatory signs.

Urban rainfall estimation employing commercial microwave links

NASA Astrophysics Data System (ADS)

Overeem, Aart; Leijnse, Hidde; Uijlenhoet, Remko; ten Veldhuis, Marie-claire

2015-04-01

Urban areas often lack rainfall information. To increase the number of rainfall observations in cities, microwave links from operational cellular telecommunication networks may be employed. Although this new potential source of rainfall information has been shown to be promising, its quality needs to be demonstrated more extensively. In the Rain Sense kickstart project of the Amsterdam Institute for Advanced Metropolitan Solutions (AMS), sensors and citizens are preparing Amsterdam for future weather. Part of this project is rainfall estimation using new measurement techniques. Innovative sensing techniques will be utilized such as rainfall estimation from microwave links, umbrellas for weather sensing, low-cost sensors at lamp posts and in drainage pipes for water level observation. These will be combined with information provided by citizens in an active way through smartphone apps and in a passive way through social media posts (Twitter, Flickr etc.). Sensor information will be integrated, visualized and made accessible to citizens to help raise citizen awareness of urban water management challenges and promote resilience by providing information on how citizens can contribute in addressing these. Moreover, citizens and businesses can benefit from reliable weather information in planning their social and commercial activities. In the end city-wide high-resolution rainfall maps will be derived, blending rainfall information from microwave links and weather radars. This information will be used for urban water management. This presentation focuses on rainfall estimation from commercial microwave links. Received signal levels from tens of microwave links within the Amsterdam region (roughly 1 million inhabitants) in the Netherlands are utilized to estimate rainfall with high spatial and temporal resolution. Rainfall maps will be presented and compared to a gauge-adjusted radar rainfall data set. Rainfall time series from gauge(s), radars and links will be compared.

Depression among older people in Europe: the EURODEP studies.

PubMed

Copeland, John R M; Beekman, Aartjan T F; Braam, Arjan W; Dewey, Michael E; Delespaul, Philippe; Fuhrer, Rebecca; Hooijer, Christopher; Lawlor, Brian A; Kivela, Sirkka-Liisa; Lobo, Anthony; Magnusson, Halgrimur; Mann, Anthony H; Meller, Ingeborg; Prince, Martin J; Reischies, Friedel; Roelands, Marc; Skoog, Ingmar; Turrina, Cesare; deVries, Marten W; Wilson, Kenneth C M

2004-02-01

The data from nine centres in Europe which had used the Geriatric Mental Scale (GMS) AGECAT were analysed to compare prevalence of diagnoses in subjects aged 65 years and over living in the community. Levels of depressive illness were: Iceland 8.8%, Liverpool 10.0%; Zaragoza 10.7%; Dublin 11.9%; Amsterdam 12.0%; Berlin 16.5%; London 17.3%; Verona 18.3% and Munich 23.6%. Taking all levels of depression, five high (Amsterdam, Berlin, Munich, London and Verona) and four low (Dublin, Iceland, Liverpool, Zaragoza) scoring centres were identified. Meta-analysis of all 13,808 subjects yielded a mean level of depression of 12.3% (95% CI 11.8-12.9), 14.1% for women (95% CI 13.5-14.8) and 8.6% for men (95% CI 7.9-9.3). Symptom levels varied between centres: 40% of the total study population in Amsterdam reported depressive mood against only 26% in Zaragoza. To incorporate studies from other centres using other methods for depression identification, the EURO-D scale was developed from 12 items of the GMS and validated against other scales and expert diagnosis. A two factor solution emerged, an 'affective suffering factor' and a 'motivation factor'. The EURO-D scale was applied to 14 population based surveys. Depression score tended to increase with age unlike levels of prevalence of depression. Large between centre differences were evident in levels of depression unexplained by age, gender or marital status. These data show that depressive illness defined as suitable for intervention is common among older people in Europe. Opportunities for effective treatment are almost certainly being lost. Levels of depressive symptoms vary significantly between high and low scoring centres, prompting the next phase of this study, an examination of risk factors in Europe.

The Island of Amsterdamøya: A key site for studying past climate in the Arctic Archipelago of Svalbard

NASA Astrophysics Data System (ADS)

Bakke, Jostein; Balascio, Nicholas; van der Bilt, Willem G. M.; Bradley, Raymond; D'Andrea, William J.; Gjerde, Marthe; Ólafsdóttir, Sædís; Røthe, Torgeir; De Wet, Greg

2018-03-01

This paper introduces a series of articles assembled in a special issue that explore Holocene climate evolution, as recorded in lakes on the Island of Amsterdamøya on the westernmost fringe of the Arctic Svalbard archipelago. Due to its location near the interface of oceanic and atmospheric systems sourced from Arctic and Atlantic regions, Amsterdamøya is a key site for recording the terrestrial response to marine and atmospheric changes. We employed multi-proxy approaches on lake sediments, integrating physical, biogeochemical, and isotopic analyses to infer past changes in temperature, precipitation, and glacier activity. The results comprise a series of quantitative Holocene-length paleoclimate reconstructions that reveal different aspects of past climate change. Each of the four papers addresses various facets of the Holocene climate history of north-western Svalbard, including a reconstruction of the Annabreen glacier based on the sedimentology of the distal glacier-fed lake Gjøavatnet, a reconstruction of changing hydrologic conditions based on sedimentology and stratigraphy in Lake Hakluytvatnet, reconstruction of summer temperature based on alkenone paleothermometry from lakes Hakluytvatnet and Hajeren, and a hydrogen isotope-based hydrological reconstruction from lake Hakluytvatnet. We also present high-resolution paleomagnetic secular variation data from the same lake, which document important regional magnetic field variations and demonstrate the potential for use in synchronizing Holocene sedimentary records in the Arctic. The paleoclimate picture that emerges is one of early Holocene warmth from ca. 10.5 ka BP interrupted by transient cooling ca. 10-8ka BP, and followed by cooling that mostly manifested as two stepwise events ca. 7 and 4 ka BP. The past 4ka were characterized by dynamic glaciers and summer temperature fluctuations decoupled from the declining summer insolation.

Exploring public databases to characterize urban flood risks in Amsterdam

NASA Astrophysics Data System (ADS)

Gaitan, Santiago; ten Veldhuis, Marie-claire; van de Giesen, Nick

2015-04-01

Cities worldwide are challenged by increasing urban flood risks. Precise and realistic measures are required to decide upon investment to reduce their impacts. Obvious flooding factors affecting flood risk include sewer systems performance and urban topography. However, currently implemented sewer and topographic models do not provide realistic predictions of local flooding occurrence during heavy rain events. Assessing other factors such as spatially distributed rainfall and socioeconomic characteristics may help to explain probability and impacts of urban flooding. Several public databases were analyzed: complaints about flooding made by citizens, rainfall depths (15 min and 100 Ha spatio-temporal resolution), grids describing number of inhabitants, income, and housing price (1Ha and 25Ha resolution); and buildings age. Data analysis was done using Python and GIS programming, and included spatial indexing of data, cluster analysis, and multivariate regression on the complaints. Complaints were used as a proxy to characterize flooding impacts. The cluster analysis, run for all the variables except the complaints, grouped part of the grid-cells of central Amsterdam into a highly differentiated group, covering 10% of the analyzed area, and accounting for 25% of registered complaints. The configuration of the analyzed variables in central Amsterdam coincides with a high complaint count. Remaining complaints were evenly dispersed along other groups. An adjusted R2 of 0.38 in the multivariate regression suggests that explaining power can improve if additional variables are considered. While rainfall intensity explained 4% of the incidence of complaints, population density and building age significantly explained around 20% each. Data mining of public databases proved to be a valuable tool to identify factors explaining variability in occurrence of urban pluvial flooding, though additional variables must be considered to fully explain flood risk variability.

Molecular epidemiology of vancomycin resistant enterococci in a tertiary care hospital in Saudi Arabia.

PubMed

Somily, Ali M; Al-Mohizea, Maha M; Absar, Muhammed M; Fatani, Amal J; Ridha, Afaaf M; Al-Ahdal, Mohammed N; Senok, Abiola C; Al-Qahtani, Ahmed A

2016-08-01

Vancomycin-resistant enterococci (VRE) are a major cause of nosocomial infections with high mortality and morbidity. There is limited data on the molecular characterization of VRE in Saudi Arabia. This study was carried out to investigate the premise that a shift in VRE epidemiology is occurring in our setting. Enterococcus species identification and susceptibility testing plus VRE phenotypic confirmation by vancomycin and teicoplanin E-test were carried out. Vancomycin resistance genes were detected by PCR. Strain typing was conducted using PFGE. Among the strains of Enterococcus spp. investigated in this study, 17 (4.5%) were VRE. With the exception of one isolate from rectal swab, all others were clinical specimens with blood being the commonest source (n = 11; 64.7%), followed by urine (n = 3; 17.6%). The 17 VRE isolates were Enterococcus faecium (n/N = 13/17) and Enterococcus gallinarum (n/N = 4/17). Among E. faecium isolates, vanA(+)/vanB(+) (n/N = 8/13; 62%) exhibiting VanB phenotype were predominant. One of the five vanA(+)E. faecium isolates exhibited a VanB phenotype indicative of vanA genotype-VanB phenotype incongruence. E. gallinarum isolates exhibited a Van C phenotype although two were vanA(+)/vanC1(+). PFGE revealed a polyclonal distribution with eight pulsotypes. These findings indicate an evolving VRE epidemiology with vanA(+)/vanB(+) isolates and vanA genotype-VanB phenotype incongruence isolates, which were previously described as colonizers, are now causing clinical infection. Copyright © 2016 Elsevier Ltd. All rights reserved.

Kinetic Theory of Plasmas

DTIC Science & Technology

2009-09-01

RTO-EN-AVT-162 means of a Coulomb potential screened at the Debye length (Delcroix and Bers, 1984; Balescu , 1988). 4. The plasma is composed of...Theory of Plasmas 2 - 28 RTO-EN-AVT-162 References Balescu , R. (1988). Transport Processes in Plasmas. Elsevier, Amsterdam. Barth, T. (2008

77 FR 31335 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

...: Parts Kit, Soft Top Troop Area Enclosure, Humvee, Tan/2540-01-329-8073 NPA: Montgomery County Chapter, NYSARC, Inc., Amsterdam, NY. Contracting Activity: Defense Logistics Agency Land and Maritime, Columbus... Defense Logistics Agency Land and Maritime, Columbus, OH. Product Names/NSNs: Ice Melt/De-Icer, 10 lbs...

STOTEN2016 Tong data

EPA Pesticide Factsheets

CTAG model inputs and outputsThis dataset is associated with the following publication:Tong, Z., R. Baldauf , V. Isakov , P.J. Deshmukh, and M. Zhang. Roadside vegetation barrier designs to mitigate near-road air pollution impacts. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 541: 920-927, (2016).

Decision-Making When Public Opinion Matters

ERIC Educational Resources Information Center

Coppock, Rob

1977-01-01

Discusses the impact of public opinion on government decision-making, and develops a model that describes how certain input or control factors can combine to produce discontinuous or divergent policy decisions. Available from: Elsevier Scientific Publishing Company, Box 211, Amsterdam, the Netherlands, single copies available. (Author/JG)

The Effect of Rotation on Legibility of Dot-Matrix Characters

DTIC Science & Technology

1991-02-01

National Standard for human factors engineering of visual display terminal workstations . Paper presented at the meeting of the Human Factors Society...Ed.), Modern issues in perception (pp. 217-226). Amsterdam: North Holland. Human Factors Society, HFS/ANSI VDT Standards Committee. (1988). American

RpoS induces expression of the Vibrio anguillarum quorum-sensing regulator VanT.

PubMed

Weber, Barbara; Croxatto, Antony; Chen, Chang; Milton, Debra L

2008-03-01

In vibrios, regulation of the Vibrio harveyi-like LuxR transcriptional activators occurs post-transcriptionally via small regulatory RNAs (sRNAs) that destabilize the luxR mRNA at a low cell population, eliminating expression of LuxR. Expression of the sRNAs is modulated by the vibrio quorum-sensing phosphorelay systems. However, vanT mRNA, which encodes a LuxR homologue in Vibrio anguillarum, is abundant at low and high cell density, indicating that VanT expression may be regulated via additional mechanisms. In this study, Western analyses showed that VanT was expressed throughout growth with a peak of expression during late exponential growth. VanO induced partial destabilization of vanT mRNA via activation of at least one Qrr sRNA. Interestingly, the sigma factor RpoS significantly stabilized vanT mRNA and induced VanT expression during late exponential growth. This induction was in part due to RpoS repressing expression of Hfq, an RNA chaperone. RpoS is not part of the quorum-sensing regulatory cascade since RpoS did not regulate expression or activity of VanO, and RpoS was not regulated by VanO or VanT. VanT and RpoS were needed for survival following UV irradiation and for pigment and metalloprotease production, suggesting that RpoS works with the quorum-sensing systems to modulate expression of VanT, which regulates survival and stress responses.

Longitudinal interrelationships between frequent geographic relocation and personality development: results from the Amsterdam Growth and Health Longitudinal Study.

PubMed

Lin, Kuan-Chia; Twisk, Jos W R; Rong, Jiin-Ru

2011-04-01

This study is part of the Amsterdam Growth and Health Longitudinal Study, which was undertaken to assess the long-term interrelationships between cumulative frequency of geographic relocation (CFGR) and the development of personality characteristics (i.e., Inadequacy, Rigidity, Social Inadequacy, Dominance, Self-sufficiency, Self-esteem, and Hostility). We found that participants who had more mobility experiences had lower consistency in their personality characteristics (the exception being Rigidity). Residential mobility from different life stages was positively associated with the continuity and change of Inadequacy and Dominance. In addition, young adults with higher Rigidity personality experienced fewer geographic moves during the transition from young adulthood to mid-life. Our study provides evidence that CFGR in different life stages may be associated with the development of personality characteristics from young adulthood to mid-life in different ways. Increased awareness of the potential interrelationships between frequent geographic relocation and personality development may have positive consequences for adult psychological health. © 2011 American Orthopsychiatric Association.

[The automated external defibrillator in the resuscitation chain. The importance of the AED examined].

PubMed

Mosterd, Arend

2015-01-01

The survival rate for those suffering an out-of-hospital cardiac arrest (OHCA) is improving slowly, with > 90% of the survivors being discharged from hospital with cognitive function intact. A recent analysis of the ARREST (AmsteRdam Resuscitation Study) group documented an increase in survival rates with favourable neurological outcome from 16.2% in 2006 to 19.7% in 2012. Only those victims whose initial cardiac rhythm is 'shockable' (i.e. ventricular fibrillation or tachycardia) reap the benefits: their survival rate increased from 29.1% to 41.4%. The prognosis for those with a non-shockable rhythm remains grim (< 5% survival). A recent analysis of the ARREST database points to the increasing use of AEDs (by laypersons, but particularly by police officers and fire-fighters with a training in basic life support) as one of the main drivers of this improved prognosis. An AED is now used in 59% of OHCA in the greater Amsterdam area, and has become an essential link in the resuscitation chain.

A summary on the effectiveness of the Amsterdam memory and attention training for children (Amat-c) in children with brain injury.

PubMed

Dvorak, Elizabeth; van Heugten, Caroline

2018-01-01

To summarise the current research on the effectiveness of the Amsterdam Memory and Attention Training for Children (Amat-c). A literature search was conducted to find articles published about the Amat-c, using PubMed, psychINFO, and PsychBITE databases. Relevant search terms included Amat-c, attention and memory, and childhood ABI. Our literature search identified 7 articles that described 5 separate studies including 61 children in total (mostly TBI). Only one study had a control group. All results indicated positive effects on memory and attention, although in three of the studies, these results were not statistically tested. Positive results were generally maintained six months follow up. This review showed that the Amat-c is effective for treating attention and memory disturbances in children with ABI. However, evidence is limited and training material is outdated. We suggest that the Amat-c should be digitised and implemented in a school setting and further evaluated.

Plasma medicine in the Netherlands

NASA Astrophysics Data System (ADS)

Kroesen, Gerrit

2012-10-01

Eindhoven, the Netherlands was one of the locations were Plasma Medicine originated: Eva Stoffels was one of the founders of the field. Since then, the attention for the field steadily increased. Nowadays, strong collaborations exist between the Eindhoven University of Technology (TU/e) and the Red Cross Burn Wound Hospital in Beverwijk, the Amsterdam Medical Center, the Maxima Medical Center in Eindhoven, the Radboud University in Nijmegen, the Free University in Amsterdam, and also companies, both large industries (Philips) and SME's (Vabrema, Lavoisier, Plastech). At TU/e we focus on the plasma itself: developing real time non-invasive diagnostics like TALIF, LIF, IF absorption, Thomson, Rayleigh and Raman scattering, mass spectroscopy, etc, while at the same time developing numerical models on the MD2D platform. For the biology, microbiology and medical aspects we rely on our colleagues who have specialized in those areas. Lesions that are studied are burn wounds, permanent inflammations, diabetic feet, skin infections, and internal diseases like Crohn's disease.

Plane crash crisis intervention: a preliminary report from the Bijlmermeer, Amsterdam.

PubMed

Gersons, B P; Carlier, I V

1993-01-01

Psychological adjustment following airline disasters shares many characteristics with adjustments following other disasters, both human and natural. On October 4, 1992, an El Al Boeing 747-F crashed into two apartment buildings in an Amsterdam suburb called the Bijlmermeer (The Netherlands). This paper gives a first impression of some of the postdisaster reactions in the affected population. It also describes the crisis intervention program (Aftercare Plan Bijlmermeer), which will be evaluated by the Bijlmer Research Project. In the Aftercare Plan for the Bijlmermeer, the organization and delivery of material aid and of medical and mental health aid was outlined. The primary goal of crisis intervention in this context is symptom relief. It is important that such programs are not looked upon as services for the mentally ill. The authors of this article plead for a better interaction between intervention and research. We need studies that can give us a better idea of the psychological effects of disaster and the effectiveness of various ways of providing postdisaster services to the public.

Associations between Safety from Crime, Cycling, and Obesity in a Dutch Elderly Population: Results from the Longitudinal Aging Study Amsterdam

PubMed Central

Kremers, Stef P. J.; de Bruijn, Gert-Jan; Visscher, Tommy L. S.; Deeg, Dorly J. H.; Thomése, G. C. Fleur; Visser, Marjolein; van Mechelen, Willem; Brug, Johannes

2012-01-01

The objective of this cross-sectional study was to investigate differences in associations between crime rates, cycling, and weight status between people living in low and high socioeconomic status (SES) neighbourhoods. In total, 470 participants in the Longitudinal Aging Study Amsterdam were included (age: 63–70 y). Body height and weight were measured using a stadiometer and calibrated weight scale, respectively. Cycling behaviour was assessed in a face-to-face interview, and neighbourhood crime rates were assessed using data from police reports. Men residing in high SES neighbourhoods cycled more than males residing in low SES neighbourhoods. Cycling was negatively related to crime rates among both men and women living in low SES neighbourhoods. Among men living in low SES neighbourhoods, more cycling was associated with lower BMI. Interventions aiming to prevent obesity in older people may consider aiming at increasing bicycle use in lower SES neighbourhoods, but neighbourhood safety issues should be considered. PMID:22523503

Neurotoxins from venoms of the Hymenoptera--twenty-five years of research in Amsterdam.

PubMed

Piek, T

1990-01-01

1. In co-operation with colleagues in Europe, Japan and the U.S.A., 25 years of research in Amsterdam have provided new views on the way some hymenopteran insects incapacitate their prey by a diversity of neurotoxins, resulting in block of synaptic transmission in CNS or neuromuscular junctions, or affecting voltage dependent phenomena in nerve and muscle fibers. 2. Nicotinic synaptic transmission in the insect CNS is irreversibly blocked at the presynaptic side by kinins, or reversibly and postsynaptically blocked by philanthotoxins. 3. Glutamatergic neuromuscular transmission is reversibly blocked by philanthotoxins at the pre- and/or postsynaptic side. 4. A presynaptic block of neuromuscular transmission was found with the Microbracon toxins. 5. An irreversible deactivation, without paralysis, of cockroaches is caused by a sting of Ampulex compressa into the suboesophageal ganglion. 6. Poneratoxin, a 25 amino acid residue polypeptide, isolated from an ant venom, is the first described hymenopteran neurotoxin affecting excitability of nerve and muscle fibres by changing the kinetics of the voltage-dependent sodium channel.

Analytical gradients for subsystem density functional theory within the slater-function-based amsterdam density functional program.

PubMed

Schlüns, Danny; Franchini, Mirko; Götz, Andreas W; Neugebauer, Johannes; Jacob, Christoph R; Visscher, Lucas

2017-02-05

We present a new implementation of analytical gradients for subsystem density-functional theory (sDFT) and frozen-density embedding (FDE) into the Amsterdam Density Functional program (ADF). The underlying theory and necessary expressions for the implementation are derived and discussed in detail for various FDE and sDFT setups. The parallel implementation is numerically verified and geometry optimizations with different functional combinations (LDA/TF and PW91/PW91K) are conducted and compared to reference data. Our results confirm that sDFT-LDA/TF yields good equilibrium distances for the systems studied here (mean absolute deviation: 0.09 Å) compared to reference wave-function theory results. However, sDFT-PW91/PW91k quite consistently yields smaller equilibrium distances (mean absolute deviation: 0.23 Å). The flexibility of our new implementation is demonstrated for an HCN-trimer test system, for which several different setups are applied. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Dynamic behaviour of a rolling tyre: Experimental and numerical analyses

NASA Astrophysics Data System (ADS)

Gonzalez Diaz, Cristobal; Kindt, Peter; Middelberg, Jason; Vercammen, Stijn; Thiry, Christophe; Close, Roland; Leyssens, Jan

2016-03-01

Based on the results of experimental and numerical analyses, the effect of rotation on the tyre dynamic behaviour is investigated. Better understanding of these effects will further improve the ability to control and optimize the noise and vibrations that result from the interaction between the road surface and the rolling tyre. Therefore, more understanding in the complex tyre dynamic properties will contribute to develop tyre design strategies to lower the tyre/road noise while less affecting other tyre performances. The presented work is performed in the framework of the European industry-academia project TIRE-DYN, with partners Goodyear, Katholieke Universiteit Leuven and LMS International. The effect of rotation on the tyre dynamic behaviour is quantified for different operating conditions of the tyre, such as load, air pressure and rotation speed. By means of experimental and numerical analyses, the effects of rotation on the tyre dynamic behaviour are studied.

Chlorhexidine Induces VanA-Type Vancomycin Resistance Genes in Enterococci

PubMed Central

Bhardwaj, Pooja; Ziegler, Elizabeth

2016-01-01

Chlorhexidine is a bisbiguanide antiseptic used for infection control. Vancomycin-resistant E. faecium (VREfm) is among the leading causes of hospital-acquired infections. VREfm may be exposed to chlorhexidine at supra- and subinhibitory concentrations as a result of chlorhexidine bathing and chlorhexidine-impregnated central venous catheter use. We used RNA sequencing to investigate how VREfm responds to chlorhexidine gluconate exposure. Among the 35 genes upregulated ≥10-fold after 15 min of exposure to the MIC of chlorhexidine gluconate were those encoding VanA-type vancomycin resistance (vanHAX) and those associated with reduced daptomycin susceptibility (liaXYZ). We confirmed that vanA upregulation was not strain or species specific by querying other VanA-type VRE. VanB-type genes were not induced. The vanH promoter was found to be responsive to subinhibitory chlorhexidine gluconate in VREfm, as was production of the VanX protein. Using vanH reporter experiments with Bacillus subtilis and deletion analysis in VREfm, we found that this phenomenon is VanR dependent. Deletion of vanR did not result in increased chlorhexidine susceptibility, demonstrating that vanHAX induction is not protective against chlorhexidine. As expected, VanA-type VRE is more susceptible to ceftriaxone in the presence of sub-MIC chlorhexidine. Unexpectedly, VREfm is also more susceptible to vancomycin in the presence of subinhibitory chlorhexidine, suggesting that chlorhexidine-induced gene expression changes lead to additional alterations in cell wall synthesis. We conclude that chlorhexidine induces expression of VanA-type vancomycin resistance genes and genes associated with daptomycin nonsusceptibility. Overall, our results indicate that the impacts of subinhibitory chlorhexidine exposure on hospital-associated pathogens should be further investigated in laboratory studies. PMID:26810654

Tussenrapportage Validatie Onderwijsvernieuwingen (Validation Assistant in Instructional Design)

DTIC Science & Technology

2007-05-01

validatie onderwij svemieuwingen D)atum mei 2007 Auteur (s) drs. J.P. van Meer drs. G,J. Veldhuis dr. M.L. van Ernmerik M.G. van Schaik Rubricering...als doel om nog beter is het van belang dat het maken van keuzes Auteur (s) passende adviezen te kunnen genereren. binnen een moeilijk grijpbaar...benaderd door de theorie achter de onderwijsconcepten te toetsen aan het oordeel van de expert. Er zijn echter beperkingen in deze opzet denkbaar die

Emergence of vanA Enterococcus faecium in Denmark, 2005-15.

PubMed

Hammerum, Anette M; Baig, Sharmin; Kamel, Yasmin; Roer, Louise; Pinholt, Mette; Gumpert, Heidi; Holzknecht, Barbara; Røder, Bent; Justesen, Ulrik S; Samulioniené, Jurgita; Kjærsgaard, Mona; Østergaard, Claus; Holm, Anette; Dzajic, Esad; Søndergaard, Turid Snekloth; Gaini, Shahin; Edquist, Petra; Alm, Erik; Lilje, Berit; Westh, Henrik; Stegger, Marc; Hasman, Henrik

2017-08-01

To describe the changing epidemiology of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis in clinical samples in Denmark 2005-15 according to species and van type, and, furthermore, to investigate the genetic relatedness of the clinical E. faecium isolates from 2015. During 2005-14, all clinical VRE isolates were tested for the presence of vanA/B/C genes by PCR. In 2015, all clinical VRE isolates were whole-genome sequenced. From the WGS data, the presence of van genes and MLST STs were extracted in silico . Core-genome MLST (cgMLST) analysis was performed for the vancomycin-resistant E. faecium isolates. During 2005-15, 1043 vanA E. faecium , 25 vanB E. faecium , 4 vanA E. faecalis and 28 vanB E. faecalis were detected. The number of VRE was <50 isolates/year until 2012 to > 200 isolates/year in 2013-15. In 2015, 368 vanA E. faecium and 1 vanB E. faecium were detected along with 1 vanA E. faecalis and 1 vanB E. faecalis . cgMLST subdivided the 368 vanA E. faecium isolates into 33 cluster types (CTs), whereas the vanB E. faecium isolate belonged to a different CT. ST203-CT859 was most prevalent (51%), followed by ST80-CT14 (22%), ST117-CT24 (6%), ST80-CT866 (4%) and ST80-CT860 (2%). Comparison with the cgMLST.org database, previous studies and personal communications with neighbouring countries revealed that the novel cluster ST203-CT859 emerged in December 2014 and spread to the south of Sweden and the Faroe Islands during 2015. VRE increased in Denmark during 2005-15 due to the emergence of several vanA E. faecium clones. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Vancomycin-resistance phenotypes, vancomycin-resistance genes, and resistance to antibiotics of enterococci isolated from food of animal origin.

PubMed

Gousia, Panagiota; Economou, Vangelis; Bozidis, Petros; Papadopoulou, Chrissanthy

2015-03-01

In the present study, 500 raw beef, pork, and chicken meat samples and 100 pooled egg samples were analyzed for the presence of vancomycin-resistant enterococci, vancomycin-resistance phenotypes, and resistance genes. Of 141 isolates of enterococci, 88 strains of Enterococcus faecium and 53 strains of E. faecalis were identified. The most prevalent species was E. faecium. Resistance to ampicillin (n = 93, 66%), ciprofloxacin (n = 74, 52.5%), erythromycin (n = 73, 51.8%), penicillin (n = 59, 41.8%) and tetracycline (n = 52, 36.9%) was observed, while 53.2% (n = 75) of the isolates were multiresistant and 15.6% (n = 22) were susceptible to all antibiotics. Resistance to vancomycin was exhibited in 34.1% (n = 30) of the E. faecium isolates (n = 88) and 1.9% (n = 1) of the E. faecalis isolates (n = 53) using the disc-diffusion test and the E-test. All isolates were tested for vanA and vanB using real-time polymerase chain reaction (PCR) and multiplex PCR, and for vanC, vanD, vanE, vanG genes using multiplex PCR only. Among E. faecalis isolates, no resistance genes were identified. Among the E. faecium isolates, 28 carried the vanA gene when tested by multiplex PCR and 29 when tested with real-time PCR. No isolate carrying the vanC, vanD, vanE, or vanG genes was identified. Melting-curve analysis of the positive real-time PCR E. faecium isolates showed that 22 isolates carried the vanA gene only, 2 isolates the vanB2,3 genes only, and seven isolates carried both the vanA and vanB2,3 genes. Enterococci should be considered a significant zoonotic pathogen and a possible reservoir of genes encoding resistance potentially transferred to other bacterial species.

EDITORIAL: Selected papers from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010) Selected papers from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010)

NASA Astrophysics Data System (ADS)

Reynaerts, Dominiek; Vullers, Ruud

2011-10-01

This special section of Journal of Micromechanics and Microengineering features papers selected from the 10th International Workshop on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2010). The workshop was organized in Leuven, Belgium from 30 November to 3 December 2010 by Katholieke Universiteit Leuven and the imec/Holst Centre. This was a special PowerMEMS Workshop, for several reasons. First of all, we celebrated the 10th anniversary of the workshop: the first PowerMEMS meeting was organized in Sendai, Japan in 2000. None of the organizers or participants of this first meeting could have predicted the impact of the workshop over the next decade. The second reason was that, for the first time, the conference organization spanned two countries: Belgium and the Netherlands. Thanks to the advances in information technology, teams from Katholieke Universiteit Leuven (Belgium) and the imec/Holst Centre in Eindhoven (the Netherlands) have been able to work together seamlessly as one team. The objective of the PowerMEMS Workshop is to stimulate innovation in micro and nanotechnology for power generation and energy conversion applications. Its scope ranges from integrated microelectromechanical systems (MEMS) for power generation, dissipation, harvesting, and management, to novel nanostructures and materials for energy-related applications. True to the objective of the PowerMEMSWorkshop, the 2010 technical program covered a broad range of energy related research, ranging from the nanometer to the millimeter scale, discussed in 5 invited and 52 oral presentations, and 112 posters. This special section includes 14 papers covering vibration energy harvesters, thermal applications and micro power systems. Finally, we wish to express sincere appreciation to the members of the International Steering Committee, the Technical Program Committee and last but not least the Local Organizing Committee. This special issue was edited in collaboration with the staff of IOP Publishing. PowerMEMS 2010 contents Harvesting energy from airflow with a michromachined piezoelectric harvester inside a Helmholtz resonator S P Matova, R Elfrink, R J M Vullers and R van Schaijk Analysis and characterization of triangular electrode structures for electrostatic energy harvestingDaniel Hoffmann, Bernd Folkmer and Yiannos Manoli A smart and self-sufficient frequency tunable vibration energy harvesterC Eichhorn, R Tchagsim, N Wilhelm and P Woias Power output enhancement of a vibration-driven electret generator for wireless sensor applicationsTatsuakira Masaki, Kenji Sakurai, Toru Yokoyama, Masayo Ikuta, Hiroshi Sameshima, Masashi Doi, Tomonori Seki and Masatoshi Oba Harvesting traffic-induced vibrations for structural health monitoring of bridgesT V Galchev, J McCullagh, R L Peterson and K Najafi Dispenser-printed planar thick-film thermoelectric energy generatorsA Chen, D Madan, P K Wright and J W Evans Silicon nanowire arrays as thermoelectric material for a power microgeneratorD Dávila, A Tarancón, M Fernández-Regúlez, C Calaza, M Salleras, A San Paulo and L Fonseca A micro thermal switch with a stiffness-enhanced thermal isolation structureTakashiro Tsukamoto, Masayoshi Esashi and Shuji Tanaka A dielectric liquid contact thermal switch with electrowetting actuationA R McLanahan, C D Richards and R F Richards A self-regulating valve for single-phase liquid cooling of microelectronicsRadu Donose, Michaël De Volder, Jan Peirs and Dominiek Reynaerts A MEMS-enabled 3D zinc-air microbattery with improved discharge characteristics based on a multilayer metallic substructureA Armutlulu, Y Fang, S H Kim, C H Ji, S A Bidstrup Allen and M G Allen Design, fabrication and testing of an air-breathing micro direct methanol fuel cell with compound anode flow fieldLuwen Wang, Yufeng Zhang, Youran Zhao, Zijiang An, Zhiping Zhou and Xiaowei Liu A shadow-mask evaporated pyroMEMS igniterD A de Koninck, D Briand and N F de Rooij Aerodynamic journal bearing with a flexible, damped support operating at 7.2 million DNTobias Waumans, Jan Peirs, Farid Al-Bender and Dominiek Reynaerts Thermoelectric energy harvester on the heated human machineVladimir Leonov

Wind and Current Forces Acting on Canadian Forces Ships During Tug Operations

DTIC Science & Technology

2002-11-01

McTaggart and Sav- age [1] describe model tests conducted on a generic frigate model to determine wind forces influencing ship capsize. Van Manen and van ...Fn will be 0.06. Based on data presented by van Manen and van Oossanen [2], the fric- tional resistance coefficient will be approximately 0.002 and...Conference on Stability of Ships and Ocean Vehicles (Melbourne, Florida, 1994). 2. J.D. van Manen and P. van Oossanen, Principles of Naval Architecture, Volume

Softwaremodule voor het Simuleren van de Gevolgen van Raketonderschepping (The Dutch Program for the Simulation of Missile Intercept Effects)

DTIC Science & Technology

2007-07-01

effects (Softwaremodule voor het simuleren van de gevolgen van raketonderschepping) 11 . AUTHOR(S) Dr E. Abadjieva, MSc R.P. Sterkenburg, MSc F. Bouquet...Softwaremnodule voor het simuleren van de gevolgen van raketonderschepping D)attini Juli 2007 Auteur(s) dr. F. Abadjicva ir. R.P Sterkenburg ir. F. Bouquet ir...P.W. D)ouip Rubricering rapport O)ngerubri ceerd Vastgesteld door Maj R. 11 . Jongkinid Vastgesteld d.d. 12 juni 2007 (Deze nitining mizil-4 sict

Items New to the Collection - Betty Petersen Memorial Library

Science.gov Websites

Symbolic-numeric Methods. Springer Verlag. Ambaum MHP. 2010. Thermal physics of the atmosphere. Hoboken ; Boston, Mass.: American Meteorological Society. Tarantola A. 1987. Inverse Problem Theory Methods for Wiley & Sons. Wilks DS. 2010. Statistical methods in the atmospheric sciences. Amsterdam: Elsevier

Diffusion Milieus as a Focus of Research on Innovation in the Public Sector

ERIC Educational Resources Information Center

Feller, Irwin; Menzel, Donald C.

1977-01-01

Presents an approach to the diffusion of technological innovations in state and local governments that is organized around the concept of "diffusion milieus." Available from: Elsevier Scientific Publishing Company, Box 211, Amsterdam, The Netherlands; single issues supplied upon request. (Author/JG)

A Bibliography on the Chemical Weathering of Granitic Rocks

DTIC Science & Technology

1988-09-01

of granite by salt action: from field to laboratory. Universitat Amsterdam FysischGeografischBoden Kwndig Laboratorium , vol. 16, pp. 67-80. Laforge, L...E. 1963. Biologische Ursachen der Wistenlackbildung. Zeitschrift fur Geornorphologie, vol. 7, pp. 112-119. Scott, G. A. J. and Street, J. M. 1976

Cognitive Abilities Relate to Self-Reported Hearing Disability

ERIC Educational Resources Information Center

Zekveld, Adriana A.; George, Erwin L. J.; Houtgast, Tammo; Kramer, Sophia E.

2013-01-01

Purpose: In this explorative study, the authors investigated the relationship between auditory and cognitive abilities and self-reported hearing disability. Method: Thirty-two adults with mild to moderate hearing loss completed the Amsterdam Inventory for Auditory Disability and Handicap (AIADH; Kramer, Kapteyn, Festen, & Tobi, 1996) and…

Magnitude and variability of land evaporation and its components at the global scale

USDA-ARS?s Scientific Manuscript database

A physics-based methodology is applied to estimate global land-surface evaporation from multi-satellite observations. GLEAM (Global Land-surface Evaporation: the Amsterdam Methodology) combines a wide range of remotely sensed observations within a Priestley and Taylor-based framework. Daily actual e...

Teachers' Goal Orientations: Effects on Classroom Goal Structures and Emotions

ERIC Educational Resources Information Center

Wang, Hui; Hall, Nathan C.; Goetz, Thomas; Frenzel, Anne C.

2017-01-01

Background: Prior research has shown teachers' goal orientations to influence classroom goal structures (Retelsdorf "et al.," 2010, "Learning and Instruction, 20," 30) and to also impact their emotions (Schutz "et al.," 2007, "Emotion in Education," Academic Press, Amsterdam, the Netherlands). However,…

[A battle of th health clubs in the Netherlands around 1840].

PubMed

van der Valk, Loes

2003-01-01

The discovery of a national inquiry into health funds in the 1840s gives cause to reconsider the traditional view on this subject. After a prosperous period under the guild regime commercial interests penetrated the health market. Its directors supposedly enriched themselves at the expense of both the insured and the professionals (general practitioners (gp's) and chemists). As things grew worse the government intervened and ordered an inquiry by a Select Committee. In reality things were slightly different. The debate on heath insurance was part and parcel of the pursuit of the medical profession to improve its standing. An alarming report on health funds by the Amsterdam medical commission spurred the Health Department to action. The national inquiry did not in fact corroborate the earlier report. In most parts of the Netherlands health insurance did not exist. In only two provinces - North and South Holland - taking out health insurance was an option and even there it was to a large extent in the cities. The three big cities - Amsterdam, Rotterdam and The Hague - accounted for 51.8 percent of all funds and as much as 72.2 percent of all persons insured. Nearly all complaints in the 1840s originated from gp's in Amsterdam. Only The Hague had the same experience i.e. infringements on private practice, enrichment by the fund governors etc. The complaints were not unlike those of the English club doctors at the end of the century. In both cities commercial health funds were important, while in Rotterdam gp's had very often been founding fathers. The author has tried to put the complaints into a wider perspective by comparing commercial funds with local clubs' and gp's own fund, the AZA, founded in 1847 to combat the disputed trend. Finally commercial funds have been compared with medical relief (number of patients and paid fees). The complaints about remuneration seem exaggerated as even AZA could not afford to pay higher fees. Commercialisation had only just started, but the new funds were more successful than the older clubs. AZA, however, proved to be even more successful. In close co-operation with poor law authorities a demarcation was introduced between medical relief and the working poor who had to take out a health insurance. AZA excluded the well-to-do from participating. Amsterdam developed a brand new health insurance policy in response to the threat of commercial funds. In the early twentieth century the story was repeated on a national level in response to proposals for compulsory sickness insurance.

The climate footprint: a practical tool to address climate change.

PubMed

Janse, T; Wiers, P

2007-01-01

Waternet supplies clean and safe drinking water to the homes of almost one million Amsterdam citizens, and also collects and treats the resulting wastewater, ensuring its safe discharge back into the water system. Climate change poses a growing challenge. Firstly Waternet is affected by the consequences of climate change, such as longer periods of drought and heavier bursts of rainfall. Secondly, the company also plays a role in causing climate change, as emissions from the Amsterdam water chain contribute to global warming. This paper aims to focus attention on mitigation as an inseparable part of adaptation-programmes. The Climate Footprint methodology is applied to the integrated Amsterdam water chain: from the point of withdrawing water from the surface/groundwater water system for drinking water production, to the point of returning the purified wastewater to the surface water/groundwater system. In-between, the water is pre-treated with chemicals, transported, purified by dune-filtration, again treated for drinking water quality, distributed over the area of Amsterdam, used in households and industries, collected from there by sewers and pumps, transported to purification plants and finally again treated with chemicals and purified to end with acceptable surface water quality. The whole process generates CO(2)-emissions in three different ways: * Sewage treatment transforms the remains of human food consumption into CO(2). These emissions do not originate from fossil fuels, but from food. They remain in a short carbon cycle and do not contribute to global warming. In fact, the sludge remaining from the purification plant is an important energy source. * Transport and purification processes require energy; this results in direct emissions e.g. in the case of fuel or natural gas use, and indirect emissions in the case of electricity. * The use of chemicals and materials for construction, transport systems, and all other facilities and services to keep the system running does require suppliers of these goods and services to consume energy and thus causes indirect emission. An inventory of these three different types of emissions is made for the (about) 1990 situation, the 2004 situation, and prognosticated for the 2007 situation. The 2004 situation reveals a 0.16 ton CO(2) equivalent emission per person. Compared to the worldwide 4 ton emission per person, this would mean a 4% contribution from the urban water system. With all the improvements scheduled, a 50% elimination of greenhouse gas emissions looks attainable for the 2007 situation. Further possibilities for emission reductions may be found by talking to suppliers about the indirect emissions.

Synergistic Interactions of Vancomycin with Different Antibiotics against Escherichia coli: Trimethoprim and Nitrofurantoin Display Strong Synergies with Vancomycin against Wild-Type E. coli

PubMed Central

Zhou, Alice; Kang, Tina Manzhu; Yuan, Jessica; Beppler, Casey; Nguyen, Caroline; Mao, Zhiyuan; Nguyen, Minh Quan

2014-01-01

Gram-negative bacteria are normally resistant to the antibiotic vancomycin (VAN), which cannot significantly penetrate the outer membrane. We used Escherichia coli mutants that are partially sensitive to VAN to study synergies between VAN and 10 other antibiotics representing six different functional categories. We detected strong synergies with VAN and nitrofurantoin (NTR) and with VAN and trimethoprim (TMP) and moderate synergies with other drugs, such as aminoglycosides. These synergies are powerful enough to show the activity of VAN against wild-type E. coli at concentrations of VAN as low as 6.25 μg/ml. This suggests that a very small percentage of exogenous VAN does enter E. coli but normally has insignificant effects on growth inhibition or cell killing. We used the results of pairwise interactions with VAN and the other 10 antibiotics tested to place VAN into a functional category of its own, as previously defined by Yeh et al. (P. Yeh, A. I. Tschumi, and R. Kishony, Nat Genet 28:489–494, 2006, http://dx.doi.org/10.1038/ng1755). PMID:25348521

Glucagon-like peptide-1 regulates brown adipose tissue thermogenesis via the gut-brain axis in rats.

PubMed

Krieger, Jean-Philippe; Santos da Conceição, Ellen Paula; Sanchez-Watts, Graciela; Arnold, Myrtha; Pettersen, Klaus G; Mohammed, Mazher; Modica, Salvatore; Lossel, Pius; Morrison, Shaun F; Madden, Christopher J; Watts, Alan G; Langhans, Wolfgang; Lee, Shin J

2018-05-30

Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose metabolism via vagal afferent neurons (VAN). Recently, VAN have received increasing attention for their role in brown adipose tissue (BAT) thermogenesis. It is however unclear whether VAN GLP-1 receptor (GLP-1R) signaling affects BAT thermogenesis and energy expenditure (EE), and whether this VAN mechanism contributes to energy balance. First, we tested the effect of the GLP-1R agonist Exendin-4 (Ex4, 0.3 μg/kg IP) on EE and BAT thermogenesis, and whether these effects require VAN GLP-1R signaling, using a rat model with a selective Glp1r knockdown (kd) in VAN. Second, we examined the role of VAN GLP-1R in energy balance during chronic high-fat diet (HFD) feeding in VAN Glp1r kd rats. Lastly, we used viral transsynaptic tracers to identify the possible neuronal substrates of such a gut-BAT interaction. VAN Glp1r kd attenuated the acute suppressive effects of Ex4 on EE and BAT thermogenesis. Consistent with this finding, the VAN Glp1r kd increased EE and BAT activity, diminished body weight gain, and improved insulin sensitivity compared to HFD-fed controls. Anterograde transsynaptic viral tracing of VAN infected major hypothalamic and hindbrain areas involved in BAT sympathetic regulation. Moreover, retrograde tracing from BAT combined with laser capture microdissection revealed that a population of VAN expressing Glp1r is synaptically connected to the BAT. Our findings reveal a novel role of VAN GLP-1R signaling in the regulation of EE and BAT thermogenesis, and imply that through this gut-brain-BAT connection intestinal GLP-1 plays a role in HFD-induced metabolic syndrome.

Evaluatie Kennistechnologische Ondersteuning bij Diagnose van SEWACO systemen (Projectmanagementplan) (Evaluation of Knowledge Technological Support for Diagnosis of SEWACO Systems (Project Management Plan)

DTIC Science & Technology

1991-08-01

diagnos van SE WACO systmnen/ AD-A245 424111 1fl1,l Niets uit deze uitgave mag warden vermenigvuldligd en/of oPenbaar gemaakt door middel van druk...fotakopie. microfilm of op welks andere whlze dan ook, zonder voorafgaande toeslemming van TNO. Hot ter inzage geven van het TNO-rapport aan direct...belanghebbenden is tegestaan. HYP. vanl OC dt Indian dit rapport in opdracht ward uitgebracht, wordt voor de, rechten en verpiichtingen van opdrachtgever en

Comparative Performance of Broadcast Bus Local Area Networks with Voice and Data Traffic

DTIC Science & Technology

1987-03-01

networks [Maxemchuk & Netravali 85, Weinstein & Forgie 831. Others have dealt with economic aspects of voice/data networks [ Gitman & Frank 78] and...88. North Holland, Amsterdam, 1981. [ Gitman & Frank 78] I. Gitman & H. Frank. Economic Analysis of Integrated Voice and Data Networks: A Case Study

77 FR 17035 - Procurement List; Proposed Additions and Deletions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-23

... agencies listed: Products Parts Kit, Soft Top Troop Area Enclosure, Humvee, Tan NSN: 2540-01-329-8073. NPA: Montgomery County Chapter, NYSARC, Inc., Amsterdam, NY. Contracting Activity: Defense Logistics Agency Land..., as aggregated by the Defense Logistics Agency Land and Maritime, Columbus, OH. Ice Melt/De-Icer NSN...

Achieving the Desired Structure of the Defense Industry in the 21st Century

DTIC Science & Technology

2008-07-01

individuals took unethical 21 and illegal actions to profit at the expense of the taxpayers. Darleen Druyun, a senior Air Force civilian employee in...Economics. 1141-44. Amsterdam: North Holland. 36. Henry, Ed and Mark Preston. 2005. "Congressman Resigns after Bribery Plea." Web page

Demographic Trends that will Shape Future Housing Demand

ERIC Educational Resources Information Center

Morrison, Peter A.

1977-01-01

Important demographic trends in the United States include 1) the population's changing age profile, 2) the tendency for young people to remain single longer, 3) the widening mortality differential between the sexes, and 4) reversal of migration trends. Available from: Elsevier Scientific Publishing Company, Box 211, Amsterdam, the Netherlands,…

Industrial Ecology Approach to MSW Methodology Data Set

EPA Pesticide Factsheets

U.S. municipal solid waste data for the year 2012. This dataset is associated with the following publication:Smith , R., D. Sengupta, S. Takkellapati , and C. Lee. An industrial ecology approach to municipal solid wastemanagement: I. Methodology. Resources, Conservation and Recycling. Elsevier Science BV, Amsterdam, NETHERLANDS, 104: 311-316, (2015).

Telecom Link--A Competitive Simulated Design Exercise.

ERIC Educational Resources Information Center

Freeman, J.; Allen, J.

1982-01-01

Telecom link is a structured design exercise concerned with building a telecommunications link between London and Amsterdam. Designed for A-level physics, the simulation requires a minimum of 10 hours. Aims of the exercise, design specifications and technical aspects, and summaries of four possible technologies used in the simulation are…

78 FR 24779 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Telemanagement Forum

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... names: China Comservice Software Technology Co., Ltd. to China Communication Service Application and... GmbH, Potsdam, GERMANY; e. Services Africa Limited, Accra, GHANA; Cognity Consulting, Maroussi, GREECE... Services Sdn Bhd, KL Sentral, MALAYSIA; ING Bank N.V., Amsterdam, NETHERLANDS; Ultrafast Fibre Limited...

Folk Linguistics and Language Teaching Education. A Case Study in an Italian Secondary School

ERIC Educational Resources Information Center

Santipolo, Matteo

2016-01-01

This paper, after shortly introducing "Folk Linguistics" by defining its domain of competence [cf. Preston, Dennis R., ed. 1999. "Handbook of Perceptual Dialectology." Amsterdam: John Benjamins; Niedzielski, Nancy A., and Dennis R. Preston. 2003. "Folk Linguistics." Berlin: Mouton de Gruyter], attempts to draw an…

Trade Union Participation in University Research Policies.

ERIC Educational Resources Information Center

Leydesdorff, Loet

1984-01-01

The recent development of Dutch research coordination agencies, the Science Shops, forms the context for a description of the relationship between university research and policy at Amsterdam University and the national trade union organization. Management tools such as project financing and other elements of this system are discussed. (MSE)

The phosphotransferase VanU represses expression of four qrr genes antagonizing VanO-mediated quorum-sensing regulation in Vibrio anguillarum

PubMed Central

Weber, Barbara; Lindell, Kristoffer; El Qaidi, Samir; Hjerde, Erik; Willassen, Nils-Peder

2011-01-01

Vibrio anguillarum utilizes quorum sensing to regulate stress responses required for survival in the aquatic environment. Like other Vibrio species, V. anguillarum contains the gene qrr1, which encodes the ancestral quorum regulatory RNA Qrr1, and phosphorelay quorum-sensing systems that modulate the expression of small regulatory RNAs (sRNAs) that destabilize mRNA encoding the transcriptional regulator VanT. In this study, three additional Qrr sRNAs were identified. All four sRNAs were positively regulated by σ54 and the σ54-dependent response regulator VanO, and showed a redundant activity. The Qrr sRNAs, together with the RNA chaperone Hfq, destabilized vanT mRNA and modulated expression of VanT-regulated genes. Unexpectedly, expression of all four qrr genes peaked at high cell density, and exogenously added N-acylhomoserine lactone molecules induced expression of the qrr genes at low cell density. The phosphotransferase VanU, which phosphorylates and activates VanO, repressed expression of the Qrr sRNAs and stabilized vanT mRNA. A model is presented proposing that VanU acts as a branch point, aiding cross-regulation between two independent phosphorelay systems that activate or repress expression of the Qrr sRNAs, giving flexibility and precision in modulating VanT expression and inducing a quorum-sensing response to stresses found in a constantly changing aquatic environment. PMID:21948044

The phosphotransferase VanU represses expression of four qrr genes antagonizing VanO-mediated quorum-sensing regulation in Vibrio anguillarum.

PubMed

Weber, Barbara; Lindell, Kristoffer; El Qaidi, Samir; Hjerde, Erik; Willassen, Nils-Peder; Milton, Debra L

2011-12-01

Vibrio anguillarum utilizes quorum sensing to regulate stress responses required for survival in the aquatic environment. Like other Vibrio species, V. anguillarum contains the gene qrr1, which encodes the ancestral quorum regulatory RNA Qrr1, and phosphorelay quorum-sensing systems that modulate the expression of small regulatory RNAs (sRNAs) that destabilize mRNA encoding the transcriptional regulator VanT. In this study, three additional Qrr sRNAs were identified. All four sRNAs were positively regulated by σ(54) and the σ(54)-dependent response regulator VanO, and showed a redundant activity. The Qrr sRNAs, together with the RNA chaperone Hfq, destabilized vanT mRNA and modulated expression of VanT-regulated genes. Unexpectedly, expression of all four qrr genes peaked at high cell density, and exogenously added N-acylhomoserine lactone molecules induced expression of the qrr genes at low cell density. The phosphotransferase VanU, which phosphorylates and activates VanO, repressed expression of the Qrr sRNAs and stabilized vanT mRNA. A model is presented proposing that VanU acts as a branch point, aiding cross-regulation between two independent phosphorelay systems that activate or repress expression of the Qrr sRNAs, giving flexibility and precision in modulating VanT expression and inducing a quorum-sensing response to stresses found in a constantly changing aquatic environment.

Review of Stantonia Ashmead (Hymenoptera, Braconidae, Orgilinae) from Vietnam, China, Japan, and Russia, with descriptions of six new species

PubMed Central

van Achterberg, Cornelis; Long, Khuat Dang; Chen, Xue-xin

2017-01-01

Abstract The genus Stantonia Ashmead, 1904 (Hymenoptera, Braconidae, Orgilinae) is reviewed for Vietnam, China, Japan, and Russia. Six new species of the genus Stantonia are described and illustrated: Stantonia brevicaudata van Achterberg, sp. n., S. dickyyui van Achterberg & Long, sp. n., S. granulata Long & van Achterberg, sp. n., S. robustifemur van Achterberg & Long, sp. n., S. stilpnosoma Long & van Achterberg, sp. n., and S. vietnamica van Achterberg, sp. n. A new subgenus (Planitonia subg. n.: type species Stantonia robustifemur van Achterberg & Long, sp. n.) is proposed for the species with a flat clypeus and face, and reduced vein r-m of the fore wing. Three species are newly recorded from Vietnam: Stantonia gracilis van Achterberg, 1987, S. sumatrana Enderlein, 1908, and S. tianmushana Chen, He & Ma, 2004. A key to species of Stantonia from Vietnam, China, Russia, and Japan is provided. PMID:29362527

Quantitative Characterization of Molecular Similarity Spaces: Tools for Computational Toxicology

DTIC Science & Technology

2000-01-20

numbers for hydrogen-filled molecular structure, hydrogen-suppressed molecular structure, and van der Waals volume. Van der Waals...relative covalent radii Geometrical Vw van der Waals volume 3DW 3-D Wiener number for the hydrogen-suppressed geometric distance matrix...molecular structure, and van der Waals volume. Van der Waals volume, Vw (Bondi 1964). was calculated using Sybyl 6.1 from Tripos As- sociates. Inc

Physical Protection: the State of the Art

DTIC Science & Technology

2005-02-01

fundamentele mechanisme van adsorptie van water beschrijft; dit is ingewikkeld en kost veel tijd ; een tweede benadering is het opstellen van een eenvoudig...gasscheidingsmethoden, bij voorkeur regeneratief, zijn zeer wenselijk vanwege de logistieke voordelen en de gegarandeerde langere operatie tijd . P(T)SA is meer...in de loop van de tijd ) met vrij simpele middelen en technieken sterk worden verbeterd. Deze technieken, zoals micro-encapsulatie en toevoeging van

Thickened boundary layer theory for air film drag reduction on a van body surface

NASA Astrophysics Data System (ADS)

Xie, Xiaopeng; Cao, Lifeng; Huang, Heng

2018-05-01

To elucidate drag reduction mechanism on a van body surface under air film condition, a thickened boundary layer theory was proposed and a frictional resistance calculation model of the van body surface was established. The frictional resistance on the van body surface was calculated with different parameters of air film thickness. In addition, the frictional resistance of the van body surface under the air film condition was analyzed by computational fluid dynamics (CFD) simulation and different air film states that influenced the friction resistance on the van body surface were discussed. As supported by the CFD simulation results, the thickened boundary layer theory may provide reference for practical application of air film drag reduction on a van body surface.

AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis

PubMed Central

Castañeda, Ximena; García-de-la-Mària, Cristina; Gasch, Oriol; Pericas, Juan M.; Armero, Yolanda; Soy, Dolors; García-González, Javier; Falces, Carlos; Ninot, Salvador; Almela, Manel; Ambrosioni, Juan; Quintana, Eduardo; Vidal, Barbara; Fuster, David; Llopis, Jaume; Soto, Sara; Moreno, Asuncion; Marco, Francesc

2017-01-01

ABSTRACT The aim of this in vivo study was to compare the efficacy of vancomycin at standard doses (VAN-SD) to that of VAN at adjusted doses (VAN-AD) in achieving a VAN area under the curve/MIC ratio (AUC/MIC) of ≥400 against three methicillin-resistant Staphylococcus aureus (MRSA) strains with different microdilution VAN MICs in an experimental endocarditis model. The valve vegetation bacterial counts after 48 h of VAN therapy were compared, and no differences were observed between the two treatment groups for any of the three strains tested. Overall, for VAN-SD and VAN-AD, the rates of sterile vegetations were 15/45 (33.3%) and 21/49 (42.8%) (P = 0.343), while the medians (interquartile ranges [IQRs]) for log10 CFU/g of vegetation were 2 (0 to 6.9) and 2 (0 to 4.5) (P = 0.384), respectively. In conclusion, this VAN AUC/MIC pharmacodynamic target was not a good predictor of vancomycin efficacy in MRSA experimental endocarditis. PMID:28373187

AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis.

PubMed

Castañeda, Ximena; García-de-la-Mària, Cristina; Gasch, Oriol; Pericas, Juan M; Armero, Yolanda; Soy, Dolors; García-González, Javier; Falces, Carlos; Ninot, Salvador; Almela, Manel; Ambrosioni, Juan; Quintana, Eduardo; Vidal, Barbara; Fuster, David; Llopis, Jaume; Soto, Sara; Moreno, Asuncion; Marco, Francesc; Miró, Jose M

2017-06-01

The aim of this in vivo study was to compare the efficacy of vancomycin at standard doses (VAN-SD) to that of VAN at adjusted doses (VAN-AD) in achieving a VAN area under the curve/MIC ratio (AUC/MIC) of ≥400 against three methicillin-resistant Staphylococcus aureus (MRSA) strains with different microdilution VAN MICs in an experimental endocarditis model. The valve vegetation bacterial counts after 48 h of VAN therapy were compared, and no differences were observed between the two treatment groups for any of the three strains tested. Overall, for VAN-SD and VAN-AD, the rates of sterile vegetations were 15/45 (33.3%) and 21/49 (42.8%) ( P = 0.343), while the medians (interquartile ranges [IQRs]) for log 10 CFU/g of vegetation were 2 (0 to 6.9) and 2 (0 to 4.5) ( P = 0.384), respectively. In conclusion, this VAN AUC/MIC pharmacodynamic target was not a good predictor of vancomycin efficacy in MRSA experimental endocarditis. Copyright © 2017 American Society for Microbiology.

Transient aerodynamic characteristics of vans during the accelerated overtaking process

NASA Astrophysics Data System (ADS)

Liu, Li-ning; Wang, Xing-shen; Du, Guang-sheng; Liu, Zheng-gang; Lei, Li

2018-04-01

This paper studies the influence of the accelerated overtaking process on the vehicles' transient aerodynamic characteristics, through 3-D numerical simulations with dynamic meshes and sliding interface technique. Numerical accuracy is verified by experimental results. The aerodynamic characteristics of vehicles in the uniform overtaking process and the accelerated overtaking process are compared. It is shown that the speed variation of the overtaking van would influence the aerodynamic characteristics of the two vans, with greater influence on the overtaken van than on the overtaking van. The simulations of three different accelerated overtaking processes show that the greater the acceleration of the overtaking van, the larger the aerodynamic coefficients of the overtaken van. When the acceleration of the overtaking van increases by 1 m/s2, the maximum drag force, side force and yawing moment coefficients of the overtaken van all increase by more than 6%, to seriously affect the power performance and the stability of the vehicles. The analysis of the pressure fields under different accelerated conditions reveals the cause of variations of the aerodynamic characteristics of vehicles.

Socialization Practices, Job Satisfaction and Commitment,

DTIC Science & Technology

1983-01-01

organizational entry practice? Neither researchers nor practitioners have directly addressed this issue. Van Manen ( Van Hasnen, 1978) identified seven dimensions...TR-2 John Van Maanen, "Some Thoughts (and Afterthoughts) on Context, Interpretation, and Organization Theory" February, 1982. TR1-3 John Van Maanen...Contradictions in Technical Careers" March, 1982; Working Paper 1281-82. TR-5 John Van Maanen & Deborah Kolb. "The Professional Apprentice: Observations on Fie1

Inventarisatie telematica-ontwikkelingen Natco (Inventory Telematics Developments Natco)

DTIC Science & Technology

1998-05-01

telefonie, die binnen afzienbare tijd een bereikbaarheid over nagenoeg de gehele wereldbol kan garanderen. Ook hier is de koppeling van netwerken van...PCS is ’de mogelijkheid voor een gebruiker te communiceren in elke gewenste vorm, op elke tijd , op elke plaats en in verschillende rollen...wat betreft plaats, tijd en tempo van het leren, kan worden gerealiseerd. De toepassing van teleleren kan leiden tot een verbetering van de interne

Evaporation from Sand

DTIC Science & Technology

1992-04-01

Instituuts Advies R2ad PML Prof. dr. U.A.Th. Brinkanl~ 36. Direactur van het Medisch Biologisch Laboratorium TNO Prof.Dr. W.R.F. Notten 37. Directeur...Grootsdialige Rampenbestrijdcing Ministerie van Binnenlandsc Zaken Drs. H. Evers 9. Adviseur van het Prins Maurits Laboratorium TWO Prot. Dr. J.M. van...Rossum, 10. Adyisew, van het Prins Maurits Laboratorium TWO Chernisdie Research Prof.Dr. G. Dijkstra 11. H~ur. NBC DMKIJOMAT/KIO Ir. AAM. Slagveer 12

Mobile Telemetry Van Remote Control Upgrade

DTIC Science & Technology

2012-05-17

Advantages of Remote Control System Upgrade • Summary Overview • Remote control of Telemetry Mobile Ground Support ( TMGS ) Van proposed to allow...NWC) personnel provided valuable data for full-function remote control of telemetry tracking vans Background • TMGS Vans support Flight Test...control capability from main TM site at Building 5790 currently allows support via TMGS Van at nearby C- 15 Site, Plant 42 in Palmdale, and as far

Synthetic Minor NSR Permit: Van Hook Crude Terminal, LLC - Van Hook Crude Terminal/Rail Loading Facility

EPA Pesticide Factsheets

This page contains the current effective synthetic minor NSR permit for the Van Hook Crude Terminal, LLC, Van Hook Crude Terminal/Rail Loading Facility, located on the Fort Berthold Indian Reservation in Mountrail County, ND.

Presence of the resistance genes vanC1 and pbp5 in phenotypically vancomycin and ampicillin susceptible Enterococcus faecalis.

PubMed

Schwaiger, Karin; Bauer, Johann; Hörmansdorfer, Stefan; Mölle, Gabriele; Preikschat, Petra; Kämpf, Peter; Bauer-Unkauf, Ilse; Bischoff, Meike; Hölzel, Christina

2012-08-01

Ampicillin and vancomycin are important antibiotics for the therapy of Enterococcus faecalis infections. The ampicillin resistance gene pbp5 is intrinsic in Enterococcus faecium. The vanC1 gene confers resistance to vancomycin and serves as a species marker for Enterococcus gallinarum. Both genes are chromosomally located. Resistance to ampicillin and vancomycin was determined in 484 E. faecalis of human and porcine origin by microdilution. Since E. faecalis are highly skilled to acquire resistance genes, all strains were investigated for the presence of pbp5 (and, in positive strains, for the penicillin-binding protein synthesis repressor gene psr) and vanC1 (and, in positive strains, for vanXYc and vanT) by using polymerase chain reaction (PCR). One porcine and one human isolate were phenotypically resistant to ampicillin; no strain was vancomycin resistant. Four E. faecalis (3/1 of porcine/human origin) carried pbp5 (MIC=1 mg/L), and four porcine strains were vanC1 positive (minimum inhibitory concentration [MIC]=1 mg/L). Real-time reverse transcriptase (RT)-PCR revealed that the genes were not expressed. The psr gene was absent in the four pbp5-positive strains; the vanXYc gene was absent in the four vanC1-positive strains. However, vanT of the vanC gene cluster was detected in two vanC1-positive strains. To our knowledge, this is the first report on the presence of pbp5, identical with the "E. faecium pbp5 gene," and of vanC1/vanT in E. faecalis. Even if resistance is not expressed in these strains, this study shows that E. faecalis have a strong ability to acquire resistance genes-and potentially to spread them to other bacteria. Therefore, close monitoring of this species should be continued.

77 FR 14583 - Notice to Manufacturers of Alternative Fuel Vans

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... Alternative Fuel Vans AGENCY: Federal Aviation Administration (FAA), U.S. DOT. ACTION: Notice to Manufacturers of Alternative Fuel Vans. SUMMARY: Projects funded under the Airport Improvement Program (AIP) must... (FAA) is considering issuing waivers to foreign manufacturers of alternative fuel vans. This notice...

Dynamical importance of van der Waals saddle and excited potential surface in C(1D)+D2 complex-forming reaction

PubMed Central

Shen, Zhitao; Ma, Haitao; Zhang, Chunfang; Fu, Mingkai; Wu, Yanan; Bian, Wensheng; Cao, Jianwei

2017-01-01

Encouraged by recent advances in revealing significant effects of van der Waals wells on reaction dynamics, many people assume that van der Waals wells are inevitable in chemical reactions. Here we find that the weak long-range forces cause van der Waals saddles in the prototypical C(1D)+D2 complex-forming reaction that have very different dynamical effects from van der Waals wells at low collision energies. Accurate quantum dynamics calculations on our highly accurate ab initio potential energy surfaces with van der Waals saddles yield cross-sections in close agreement with crossed-beam experiments, whereas the same calculations on an earlier surface with van der Waals wells produce much smaller cross-sections at low energies. Further trajectory calculations reveal that the van der Waals saddle leads to a torsion then sideways insertion reaction mechanism, whereas the well suppresses reactivity. Quantum diffraction oscillations and sharp resonances are also predicted based on our ground- and excited-state potential energy surfaces. PMID:28094253

International Hydrogenase Conference (7th) Held at the University of Reading on August 24th to 29th 2004.

DTIC Science & Technology

2004-08-19

Johannes Hackstein [ PB GIO rNovel Fe-hydrogenases from the rumen ciliate metagenome . :12.50 :114.00 -1 Lunch [ 114.00 1 7.00 1 Poster Session 2...d.r.o’ g’.e n-.a-.s.e..s from the rumnen ciliate metagenome . p36 Severing, E., Boxma, B., van Alen, T.A., Ricard, G., van Hoek, A.H.A.M., Moon-van...hydrogenases from the rumen ciliate metagenome . Severing, E.’, Boxma, B.1, van Alen, T.A.’, Ricard, G.z, van Hoek, A.H.A.M.’, Moon-van der Staay, S.Y

Genetics Home Reference: bare lymphocyte syndrome type II

MedlinePlus

... 6. Citation on PubMed Gobin SJ, Peijnenburg A, van Eggermond M, van Zutphen M, van den Berg R, van den Elsen PJ. The RFX complex is crucial ... D, Szöllosi J, Jenei A. Bare lymphocyte syndrome: an opportunity to discover our immune system. Immunol Lett. ...

Measurements of Propeller-Induced Unsteady Surface Force and Pressures

DTIC Science & Technology

1986-12-01

investigations using foreshortened hull models in the determination of cavitating propeller-induced pressure pulses include van Manen , 46 Huse,47 van Oossanen...Nov 1974). 46. van Manen , J.D., "The Effect of Cavitation on the Interaction Between Propeller and Ship’s Hull, "International Shipbuilding Progress...and van der Kooij,48 and van der Kooij and Jonk. 49 Examples of more recent publications that have either made use of results from dummy model tests or

Job Oriented Training: Onderwijskundige Grondslag en Onderbouwing (Job Oriented Training: Foundation and Empirical Support)

DTIC Science & Technology

2008-07-01

die binmen defensie tot aanzien van de effecten van JOT onderwijs met het nieuwe leren terug te dan toe in gebruik waren bij het theorie - voeren is op...problemen in de uitvoerings- onderwijs; toepassing van JOT impliceerde Grondslag praktijk van datzeltde regulier onderwijs. dat er geen theorie meer...het rechte eind Opdrachtnummer Datum PROGRAMMA PROJECT juli 2008 Program mabegeleider Projectbegeleider Auteur (s) IkolP.M.. Bonen,dr. A.H. van der

Combination Vancomycin/Cefazolin (VAN/CFZ) for Methicillin-Resistant Staphylococcus aureus (MRSA) Bloodstream Infections (BSI)

PubMed Central

Trinh, Trang D; Zasowski, Evan J; Lagnf, Abdalhamid M; Bhatia, Sahil; Dhar, Sorabh; Mynatt, Ryan; Pogue, Jason M; Rybak, Michael J

2017-01-01

Abstract Background VAN remains the standard for MRSA BSI but has been associated with treatment failures and resulted in prolonged BSI durations and recurrences. In vitro studies of VAN/CFZ against MRSA demonstrated synergy and prevention of VAN resistance. However, clinical use of VAN/CFZ has not been reported. The objective of this study was to compare patient outcomes treated with VAN/CFZ vs. VAN for MRSA BSI. Methods This was a retrospective, cohort, comparative-effectiveness study of hospitalized adults ≥18y with ≥1 MRSA blood culture and received VAN/CFZ combination for ≥24h or VAN alone initiated within 72h of index infection between 1/1/08 and 5/1/17. Patients who received >24h β-lactams other than CFZ, MRSA-active antibiotics other than VAN, with polymicrobial BSI, or had a second MRSA BSI episode during the study period were excluded. The primary composite failure outcome included: 30d mortality, MRSA BSI ≥7d, and 60d recurrence. Demographics were compared by Χ2, Fisher’s exact, Student’s t, or Mann–Whitney U tests. Multivariable regression models compared outcomes between the two treatment groups. Covariates with p-values ≤0.2 in bivariate analyses were included in the model. Results A total of 101 patients were included (CFZ/VAN = 41, VAN = 60). Demographics were similar except VAN patients were older (mean (±SD) age 58 (±14) v. 51 (±18) y, P = 0.04), had higher median (IQR) Charlson Comorbidity Index (3 (2-5) v. 1 (0–4), P < 0.01), APACHE II scores (13 (8-18) v. 11 (8-18), P = 0.2), and more endocarditis BSI source (37% v. 20%, P = 0.06). After accounting for BSI source, VAN/CFZ (adjusted odds ratio [aOR], 95% confidence intervals [CI], 0.33, 0.13-0.83) and low APACHE II scores (aOR 1.07, 95% CI 1–1.15) were independently associated with fewer failures. Bivariate outcomes are in table below: Variable, n (%) VAN/CFZ VAN P value Composite failure 10 (24) 31 (52) 0.006 30d mortality 3 (7.3) 5 (8.3) 1 BSI ≥7d 6 (15) 21 (35) 0.023 60d recurrence 3 (7.3) 9 (15) 0.351 Failure switch 1 (2.4) 10 (17) 0.026 Conclusion In this cohort of MRSA BSI, patients treated with VAN/CFZ experienced fewer failures than with VAN alone, with shorter BSI durations. Additional studies are needed to confirm the role of VAN/CFZ combination treatment for MRSA BSI. Disclosures J. M. Pogue, Achaogen, Inc.: Consultant, Consulting fee. M. J. Rybak, Allergen: Scientific Advisor, Consulting fee.

Shell Nouns as Cohesive Devices in Published and ESL Student Writing

ERIC Educational Resources Information Center

Aktas, Rahime Nur; Cortes, Viviana

2008-01-01

This paper analyzes the use of a special type of unspecific noun, called "shell nouns" [Hunston, S., & Francis, G. (1999). "Pattern grammar". Amsterdam: Benjamins; Schmid, H. (2000). "English abstract nouns as conceptual shells: From corpus to cognition". Berlin: Walter de Gruyter], which are frequently used as cohesive devices, in the written…

Playing the City: Public Participation in a Contested Suburban Area

ERIC Educational Resources Information Center

Lauwaert, Maaike

2009-01-01

This article presents one case study of public participation in urban planning: the "Face Your World" project that took place in 2005 in the suburban area of Slotervaart, close to the Dutch city of Amsterdam. "Face Your World" was a participation project that aimed at engaging both younger and immigrant inhabitants of…

Reporting of Subscores Using Multidimensional Item Response Theory

ERIC Educational Resources Information Center

Haberman, Shelby J.; Sinharay, Sandip

2010-01-01

Recently, there has been increasing interest in reporting subscores. This paper examines reporting of subscores using multidimensional item response theory (MIRT) models (e.g., Reckase in "Appl. Psychol. Meas." 21:25-36, 1997; C.R. Rao and S. Sinharay (Eds), "Handbook of Statistics, vol. 26," pp. 607-642, North-Holland, Amsterdam, 2007; Beguin &…

Participation and Selection Effects of a Voluntary Selection Process

ERIC Educational Resources Information Center

Schripsema, Nienke R.; van Trigt, Anke M.; Lucieer, Susanna M.; Wouters, Anouk; Croiset, Gerda; Themmen, Axel P. N.; Borleffs, Jan C. C.; Cohen-Schotanus, Janke

2017-01-01

Many different medical school selection processes are used worldwide. In this paper, we examine the effect of (1) participation, and (2) selection in a voluntary selection process on study performance. We included data from two cohorts of medical students admitted to Erasmus MC, Rotterdam and VUmc, Amsterdam, The Netherlands and compared them to…

Some Adjectival Nominalizations in English

ERIC Educational Resources Information Center

Bowers, John S.

1975-01-01

This paper concludes that there is evidence in favor of handling the derived nominals of Predicate AP's with a lexicalist theory, in conjunction with a base schema of the form (1)-(2). The transformation NP-Postposing is proposed to explain variations. (Available from North-Holland Publishing Co., P. O. Box 211, Amsterdam, The Netherlands.) (CHK)

Pupils' Religious Identity Formation for a Secular Age

ERIC Educational Resources Information Center

Miedema, Siebren

2010-01-01

Starting his work as endowed Hendrik Pierson Professor for Christian Education at VU University Amsterdam in 1993 the author focused on the relationship of education, pedagogy, and religion. However, his attention was rather exclusively directed to Protestant schools. The argument was that in academia at that time, even in the faculties of…

An Analysis of Japanese University Students' Oral Performance in English Using Processability Theory

ERIC Educational Resources Information Center

Sakai, Hideki

2008-01-01

This paper presents a brief summary of processability theory as proposed by [Pienemann, M., 1998a. "Language Processing and Second Language Development: Processability Theory." John Benjamins, Amsterdam; Pienemann, M., 1998b. "Developmental dynamics in L1 and L2 acquisition: processability theory and generative entrenchment." "Bilingualism:…

Child Guidance and Mental Health in the Netherlands

ERIC Educational Resources Information Center

Bakker, Nelleke

2006-01-01

In the Netherlands, as in the United States, the introduction of the concept of "mental health" in education is closely related to the development of a network of child guidance clinics. The first of these was established in Amsterdam in 1928. However, a substantial movement to actively promote mental health did not come into existence…

Fortress Europe in the Field: Academics, Immigrants, and Methodological Considerations for Educational Studies

ERIC Educational Resources Information Center

Mielants, Eric; Weiner, Melissa F.

2015-01-01

This article addresses the difficulty of local-level qualitative educational research in Amsterdam in light of changes related to contemporary political discourse on decades of immigration, especially from the 1970s onward, and increasingly critical assessments of Dutch education in the literature. It considers recent developments in the…

The International Attitudes and Knowledge of Adolescents in Nine Countries: The IEA Civic Education Survey

ERIC Educational Resources Information Center

Torney, Judith V.

1977-01-01

Data concerning political attitudes and knowledge were collected for 30,000 adolescents in nine countries. Findings indicate that students in countries with a high degree of international contact were more internationally minded. Sampling procedures are described. Available from: Elsevier Scientific Publishing Company, P.O. Box 211, Amsterdam, The…

model outputs

EPA Pesticide Factsheets

Figures 1-10 and Table 1This dataset is associated with the following publication:Chang, S.Y., S. Arunachalam, A. Valencia, B. Naess, V. Isakov , M. Breen , T. Palma , and W. Vizuete. A modeling framework for characterizing near-road air pollutant concentration at community scales. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 538: 905-921, (2015).

Ethics and the Unintended Consequences of Social Research: A Perspective from the Sociology of Science

ERIC Educational Resources Information Center

Studer, Kenneth E.; Chubin, Daryl E.

1977-01-01

Argues that "successful" social science requires development of a social ethic or sense of research responsibility, and suggests that an individualistic orientation is ineffective in coping with the unintended consequences of social research. Available from: Elsevier Scientific Publishing Company, Box 211, Amsterdam, the Netherlands, single copies…

Sorption of Radionuclides to Building Materials and its Removal Using Simple Wash Solutions

EPA Pesticide Factsheets

Data corresponding to the figures in the paper.This dataset is associated with the following publication:Kaminski, M., C. Mertz, L. Ortega, and N. Kivenas. Sorption of Radionuclides to Building Materials and its Removal Using Simple Wash Solutions. Journal of Environmental Chemical Engineering. Elsevier B.V., Amsterdam, NETHERLANDS, ., (2016).

Diverse Classrooms--Opportunities and Challenges

ERIC Educational Resources Information Center

van Driel, Barry; van Dijk, Lutz

2010-01-01

In April 2009, the Anne Frank House in Amsterdam invited more than 30 experts in the field of Holocaust education from a dozen countries for a three-day seminar to share their thoughts and experiences to provide insight into the kinds of opportunities and challenges educators might face in the future when teaching about the Holocaust in diverse…

77 FR 61452 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Designation of Longer...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

...; Letter from Daniel G. Weaver, Ph.D., Professor of Finance, Rutgers Business School, dated April 26, 2012; Letter from Amber Anand, Associate Professor of Finance, Syracuse University, dated April 29, 2012; Letter from Albert J. Menkveld, Associate Professor of Finance, VU University Amsterdam, dated May 2...

Pattern and Meaning across Genres and Disciplines: An Exploratory Study

ERIC Educational Resources Information Center

Groom, Nicholas

2005-01-01

Work in corpus linguistics has led to the development of a theory of language as "phraseology" [Hunston, S., & Francis, G. (1999). "Pattern grammar: A corpus-driven approach to the lexical grammar of English." Amsterdam: John Benjamins. Sinclair, J. M. (1991). "Corpus, concordance, collocation." Oxford: Oxford University Press. Sinclair, J. M.…

Higher Integrability for Minimizers of the Mumford-Shah Functional

NASA Astrophysics Data System (ADS)

De Philippis, Guido; Figalli, Alessio

2014-08-01

We prove higher integrability for the gradient of local minimizers of the Mumford-Shah energy functional, providing a positive answer to a conjecture of De Giorgi (Free discontinuity problems in calculus of variations. Frontiers in pure and applied mathematics, North-Holland, Amsterdam, pp 55-62, 1991).

Ship Shape

ERIC Educational Resources Information Center

Sartorius, Tara Cady

2009-01-01

Ed Willis Barnett had quite a military training: he attended the United States Naval Academy in Annapolis, Maryland, (1917 to 1920) and served in both World Wars. He was also an accomplished fencer, and earned a position on the 1928 U.S. Olympic fencing team. That year the summer Olympics were held in Amsterdam, so he traveled to Europe for the…

Combat Risk and Pay: Theory and Some Evidence

DTIC Science & Technology

2011-10-01

Kavanagh, and Laura Miller. 2006. “How Deployments Affect Service Members.” RAND Report MG432. Hosek, James R. and Mark E. Totten . 2004. “The Effect of...Richard Layard, 12: 641 92. Amsterdam, Netherlands: North Holland Publishing Co. Shogren, Jason F. and Tommy Stamland. 2002. “Skill and the Value of

Inguinal hernia repair in the Amsterdam region 1994-1996.

PubMed

Schoots, I G; van Dijkman, B; Butzelaar, R M; van Geldere, D; Simons, M P

2001-03-01

In the Netherlands, approximately 30,000 inguinal hernia repairs are performed yearly. At least 15% are for recurrence. New procedures are being introduced creating discussion on which technique is the best. Currently it is not possible to choose on evidence alone because of the long follow-up that is needed. In 1996 an inventory was taken of all inguinal hernia repairs that were performed in the Amsterdam region (9 hospitals). These results were compared with the results from a similar study performed in 1994. Major changes in treatment strategy were noted. The Bassini repair was replaced by Shouldice and Lichtenstein techniques. There was a significant increase in the use of prostheses for both primary and recurrent inguinal hernias. There was no significant decrease in the percentage of operations performed for recurrent hernia from 19.5% to 16.8%. However, there was a significant decrease in operations performed for early recurrences (5.1%-3.4%) (p = 0.05). These results suggest that the Shouldice and Lichtenstein repairs may be superior to the Bassini repair in terms of early hernia recurrence.

Capturing commemoration: Using mobile recordings within memory research

PubMed Central

Birdsall, Carolyn; Drozdzewski, Danielle

2017-01-01

This paper details the contribution of mobile devices to capturing commemoration in action. It investigates the incorporation of audio and sound recording devices, observation, and note-taking into a mobile (auto)ethnographic research methodology, to research a large-scale commemorative event in Amsterdam, the Netherlands. On May 4, 2016, the sounds of a Silent March—through the streets of Amsterdam to Dam Square—were recorded and complemented by video grabs of the march’s participants and onlookers. We discuss how the mixed method enabled a multilevel analysis across visual, textual, and aural layers of the commemorative atmosphere. Our visual data aided in our evaluation of the construction of collective spectacle, while the audio data necessitated that we venture into new analytic territory. Using Sonic Visualiser, we uncovered alternative methods of “reading” landscape by identifying different sound signatures in the acoustic environment. Together, this aural and visual representation of the May 4 events enabled the identification of spatial markers and the temporal unfolding of the Silent March and the national 2 minutes’ silence in Amsterdam’s Dam Square. PMID:29780585

Translational HIV-1 research: from routine diagnostics to new virology insights in Amsterdam, the Netherlands during 1983-2013

PubMed Central

2013-01-01

An HIV-1 diagnostic laboratory was established in the Academic Medical Center (AMC) of the University of Amsterdam after the discovery of human immunodeficiency virus (HIV) as the cause of the acquired immunodeficiency syndrome (AIDS). The first AIDS patients were diagnosed here in 1981 and since 1983 we have tested the samples of 50992 patients using a variety of assays that greatly improved over the years. We will describe some of the basic results from this diagnostic laboratory and then focus on the spin-off in terms of the development of novel virus assays to detect super-infections and ultra-sensitive assays to measure the intracellular HIV-1 RNA load. We also review several original research findings in the field of HIV-1 virology that stem from initial observations made in the diagnostic unit. This includes the study of genetic defects in the HIV-1 genome and time trends of the replication fitness over 30 years of viral evolution, but also the description of novel HIV-1 variants in difficult-to-diagnose clinical specimen. PMID:23985078

Translational HIV-1 research: from routine diagnostics to new virology insights in Amsterdam, the Netherlands during 1983-2013.

PubMed

van der Kuyl, Antoinette C; Bakker, Margreet; Jurriaans, Suzanne; Back, Nicole K T; Pasternak, Alexander O; Cornelissen, Marion; Berkhout, Ben

2013-08-28

An HIV-1 diagnostic laboratory was established in the Academic Medical Center (AMC) of the University of Amsterdam after the discovery of human immunodeficiency virus (HIV) as the cause of the acquired immunodeficiency syndrome (AIDS). The first AIDS patients were diagnosed here in 1981 and since 1983 we have tested the samples of 50992 patients using a variety of assays that greatly improved over the years. We will describe some of the basic results from this diagnostic laboratory and then focus on the spin-off in terms of the development of novel virus assays to detect super-infections and ultra-sensitive assays to measure the intracellular HIV-1 RNA load. We also review several original research findings in the field of HIV-1 virology that stem from initial observations made in the diagnostic unit. This includes the study of genetic defects in the HIV-1 genome and time trends of the replication fitness over 30 years of viral evolution, but also the description of novel HIV-1 variants in difficult-to-diagnose clinical specimen.

Learning from Profiles of the Special Needs Gifted

ERIC Educational Resources Information Center

Swanson, Julie Dingle; Van Tassel-Baska, Joyce; Feng, Annie; Chandler, Kimberley

2007-01-01

Through a longitudinal study focused on identification policy that is inclusive of underrepresented gifted students (Van Tassel-Baska & Feng, 2003; Van Tassel-Baska, Feng, & deBrux, under review; Van Tassel-Baska, Feng, & Evans, in press; Van Tassel-Baska, Johnson, & Avery, 2002), a team of researchers developed case studies of special needs…

78 FR 47487 - Notice of Proposed Buy America Waiver

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

... (NFRMPO). NFRMPO is in the process of procuring vehicles for its vanpool program, ``VanGo.'' In accordance... Organization (NFRMPO). NFRMPO operates a vanpool (``VanGo'') program, which has 75 vans with routes connecting, among others, Fort Collins, Loveland, Greeley, Denver, and Boulder, Colorado. The VanGo program carries...

Representation of Research Paradigms as a Function of Familiarity with Research Domains

DTIC Science & Technology

1992-07-01

van de paradigma’s te kunnen vaststellen. Keuze van het Juiste paradigma werd bepaald door proefpersonen te vragen de betreffende zin te classificeren...als afkomstig van een bepaaid type onderzoek. De innoud van het paradigma werd bepaald door proefpersonen te, vragen zoveel kenmerken voor bet

Additional Value from Road Mapping in Defense Policy Making (meerwaarde van roadmapping bij beleidsontwikkeling van de koninklijke landmacht)

DTIC Science & Technology

2006-05-01

van zogonaamde strategische reserves tot bijvaarbeeld lakaal boschikbare gevechtscapacitoit. 9 11 Joint. Do Nederlandse krijgsmacht ontwikkelt zich tot...8 2 W erkwijze van de KL tot nu toe ............................................................................... 9 2.1 O...ntwikkeling visiedocurnent ....................................................................................... 9 2.2 Opzet beleid- en deelstudies

Structuring of the Renewed Decision Making Process in the Royal Netherlands Army (Structurering van het vernieuwde besluitvormingsproces binnen de KL).

DTIC Science & Technology

1996-10-10

time informatie wordt door Eisenhardt (1989) gedefinieerd als " information about a firm’s operations or environment for which there is little or no...op het invoeren van (getypte) tekst . Conclusie Elektronisch Brainstormen: * in principe geschikt om Eigen Mogelijkheden te genereren, vooral als de...Capaieairt ca •acitenit ca a• C ie•lit Fig. 1 Mogelijke wijzen van besluitvorming (zie tekst ) als functie van beschik- bare tijd, capaciteit en ervaring van

The Design of a Propeller for a U.S. Coast Guard Icebreaker Tugboat

DTIC Science & Technology

1975-10-01

series as investigated by Van Lammeren, Van Manen , and Oosterveld . This propeller series, commonly referred to as the K’jgeningen B-screw series...RtFEKENCES Van Lammeren, W.P.A., Van Manen , J.D., and Oosterveld, M.W.C., "The Wageningen B-Screw Series," Transactions of the Society of Naval Architects...forces has been reported by Van Gunsteren and Pronk . They investigated both single and twin screw ships of various types and the results are

The Role of b-Catenin in Mammary Gland Carcinogenesis

DTIC Science & Technology

2002-03-01

Wetering, M., Cavallo, R., Dooijes, D., van Beest , M., van Es, J., Loureiro, J., Ypma, A., hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M...Transduction Lab - domain of /3-catenin. oratories) and anti-KT3 (Babco) were used as primary Elevated levels of fl-catenin were recently observed in antibodies...1988). Cell, 55, 619 -625. Kolligs FT, Hu G, Dang CV and Fearon ER. (1999). Mol. van de Wetering M, Cavallo R, Dooijes D, van Beest M, van Cell. Biol

MATE (Mentale Aspecten van Team Effectiviteit) (MATE (Mental Aspects of Team Effectiveness))

DTIC Science & Technology

2008-05-01

0 Auteur (s) drs. J.P. van Meer drs. MI. 1 ’ IIart0 drs. 1. van der 16. Rubricering rapport Ongerubriceerd Vastgesteld door Ikol drs. L.A. de Vos...team Auteur (s) Teamntraining drs. J.P. van Meer drs. M.H.E. I Hart Programmanummer Projectnummer drs. 1. van der Beijl V406 015.34095 Rubricering...Murphy & Cleveland (1995) geven inzicht in de tearngedragingen die meetbaar zijn en de theorie over Shared Mental Models (Espevik et al, 2006) laat zien

De Ontwikkeling van een PBPK Model voor VX; Stand van Zaken V013-813 en 207C (The Development of a PBPK Model for VX: Status Report)

DTIC Science & Technology

2006-02-01

ing. H.C. Trap, dr. ir. M.J. van der werd zes maal gesproken over de Schans, ing. L.F. Chau, B.). Lander, invulling en de voortgang van het I.A. Cordia ...dr. ir. M.J. van der Schans, ing. L.F. Chau, J.P. Oostdijk, B.J. Lander, l.A. Cordia 25 TNO Defensie en Veiligheid, vestiging Rijswijk, Marketing en

Speed Measuring System (Detectoren en Signaalbewerking Voor Het Snelheidsmeetsysteem 4-01)

DTIC Science & Technology

1989-03-01

een hogere nauwkeurigheid te halen dan san de voet van bet signasi mogelijk is bij een grote signaalaniplitude, Wanneer de S/L < 6 is wordt de drempel...snelheidsmeetsysteem 4-01 Niets Uilf deze ultgave mag worden vermenigvuldigd en of openbaar gemaakt door mlddel van druk fotokope microfilm autour~s): of op welke...andere wijze dan 006 zonder voorafgaarode toestemming van TNO J. van der Haven Hetlter I zage geven van net TNO-rappoit aan direct belanghebbenoen is

Eisen voor Buitenbeelden van Voertuigsimulatoren: Een Literatuurstudie (Use of Exterior Pictures in Vehicle Simulators: A Literature Survey)

DTIC Science & Technology

1991-06-01

1.3 Opleiding en onderzoek met voertuigsimulatoren 9 1.4 Opbouw van simulatoren 11 1.5 Totstandkomning van beelden in CGI-systemen 13 1.6 Bepalen van...pictures in vehicle simulators. A literature survey s 029 9 20 Aantal bladzijden: 102 .JISTRIBIYI±WN- STATEMEN9 -2 39 Approved for public release; 2 28 9 ...Achteruitkijkspiegels en verrekijkers 79 8.2 Helderheidsversterkers en warmtebeelden 80 8.3 Middelen om afstand te bepalen 80 9 INTERACTIES VAN HET

A Case-Control Study of Molecular Epidemiology in Relation to Azithromycin Resistance in Neisseria gonorrhoeae Isolates Collected in Amsterdam, the Netherlands, between 2008 and 2015

PubMed Central

Wind, Carolien M.; Bruisten, Sylvia M.; Schim van der Loeff, Maarten F.; Dierdorp, Mirjam; de Vries, Henry J. C.

2017-01-01

ABSTRACT Neisseria gonorrhoeae resistance to ceftriaxone and azithromycin is increasing, which threatens the recommended dual therapy. We used molecular epidemiology to identify N. gonorrhoeae clusters and associations with azithromycin resistance in Amsterdam, the Netherlands. N. gonorrhoeae isolates (n = 143) were selected from patients visiting the Amsterdam STI Outpatient Clinic from January 2008 through September 2015. We included all 69 azithromycin-resistant isolates (MIC ≥ 2.0 mg/liter) and 74 frequency-matched susceptible controls (MIC ≤ 0.25 mg/liter). The methods used were 23S rRNA and mtrR sequencing, N. gonorrhoeae multiantigen sequence typing (NG-MAST), N. gonorrhoeae multilocus variable-number tandem-repeat analysis (NG-MLVA), and a specific PCR to detect mosaic penA genes. A hierarchical cluster analysis of NG-MLVA related to resistance and epidemiological characteristics was performed. Azithromycin-resistant isolates had C2611T mutations in 23S rRNA (n = 62, 89.9%, P < 0.001) and were NG-MAST genogroup G2992 (P < 0.001), G5108 (P < 0.001), or G359 (P = 0.02) significantly more often than susceptible isolates and were more often part of NG-MLVA clusters (P < 0.001). Two resistant isolates (2.9%) had A2059G mutations, and five (7.3%) had wild-type 23S rRNA. No association between mtrR mutations and azithromycin resistance was found. Twenty-four isolates, including 10 azithromycin-resistant isolates, showed reduced susceptibility to extended-spectrum cephalosporins. Of these, five contained a penA mosaic gene. Four of the five NG-MLVA clusters contained resistant and susceptible isolates. Two clusters consisting mainly of resistant isolates included strains from men who have sex with men and from heterosexual males and females. The co-occurrence of resistant and susceptible strains in NG-MLVA clusters and the frequent occurrence of resistant strains outside of clusters suggest that azithromycin resistance develops independently from the background genome. PMID:28373191

Radio-frequency electromagnetic field (RF-EMF) exposure levels in different European outdoor urban environments in comparison with regulatory limits.

PubMed

Urbinello, Damiano; Joseph, Wout; Huss, Anke; Verloock, Leen; Beekhuizen, Johan; Vermeulen, Roel; Martens, Luc; Röösli, Martin

2014-07-01

Concerns of the general public about potential adverse health effects caused by radio-frequency electromagnetic fields (RF-EMFs) led authorities to introduce precautionary exposure limits, which vary considerably between regions. It may be speculated that precautionary limits affect the base station network in a manner that mean population exposure unintentionally increases. The objectives of this multicentre study were to compare mean exposure levels in outdoor areas across four different European cities and to compare with regulatory RF-EMF exposure levels in the corresponding areas. We performed measurements in the cities of Amsterdam (the Netherlands, regulatory limits for mobile phone base station frequency bands: 41-61 V/m), Basel (Switzerland, 4-6 V/m), Ghent (Belgium, 3-4.5 V/m) and Brussels (Belgium, 2.9-4.3 V/m) using a portable measurement device. Measurements were conducted in three different types of outdoor areas (central and non-central residential areas and downtown), between 2011 and 2012 at 12 different days. On each day, measurements were taken every 4s for approximately 15 to 30 min per area. Measurements per urban environment were repeated 12 times during 1 year. Arithmetic mean values for mobile phone base station exposure ranged between 0.22 V/m (Basel) and 0.41 V/m (Amsterdam) in all outdoor areas combined. The 95th percentile for total RF-EMF exposure varied between 0.46 V/m (Basel) and 0.82 V/m (Amsterdam) and the 99th percentile between 0.81 V/m (Basel) and 1.20 V/m (Brussels). All exposure levels were far below international reference levels proposed by ICNIRP (International Commission on Non-Ionizing Radiation Protection). Our study did not find indications that lowering the regulatory limit results in higher mobile phone base station exposure levels. Copyright © 2014 Elsevier Ltd. All rights reserved.

Clonally Related Neisseria gonorrhoeae Isolates with Decreased Susceptibility to the Extended-Spectrum Cephalosporin Cefotaxime in Amsterdam, the Netherlands

PubMed Central

Heymans, Raymond; Bruisten, Sylvia M.; Golparian, Daniel; Unemo, Magnus; de Vries, Henry J. C.

2012-01-01

From 2006 to 2008, Neisseria gonorrhoeae isolates were identified with decreased susceptibility to the extended-spectrum cephalosporin (ESC) cefotaxime among visitors of the Amsterdam sexually transmitted infections (STI) clinic, the Netherlands. Spread, clonality, and characteristics of 202 isolates were examined using antibiograms, conventional penA mosaic gene PCR, and N. gonorrhoeae multiple-locus variable-number tandem repeat analysis (NG-MLVA). A strictly defined subset was further characterized by N. gonorrhoeae multiantigen sequence typing (NG-MAST) and sequencing of ESC resistance determinants (penA, mtrR, and porB1b). Seventy-four N. gonorrhoeae isolates with a cefotaxime MIC of >0.125 μg/ml (group A), 54 with a cefotaxime MIC of 0.125 μg/ml (group B), and a control group of 74 with a cefotaxime MIC of <0.125 μg/ml (group C) were included. Fifty-three clonally related penA mosaic-positive isolates (penicillin-binding protein 2 type XXXIV) were identified in group A (n = 47 isolates; 64%) and B (n = 6 isolates; 11%). The 53 penA mosaic-positive isolates were predominantly NG-MAST ST1407 (87%) and contained an mtrR promoter A deletion (98%) and porB1b alterations G101K/A102N. All were assigned to the same NG-MLVA cluster that comprised in total 56 isolates. A correlation was found between decreased cefotaxime susceptibility and ST1407 that was highly prevalent among visitors of the Amsterdam STI clinic. The rapid spread of this strain, which also has been identified in many other countries, might be facilitated by high-risk sexual behavior and should be monitored closely to identify potential treatment failure. Quality-assured surveillance of ESC susceptibility on the national and international levels and exploration of new drugs and/or strategies for treatment of gonorrhea are crucial. PMID:22214779

Ethnic and regional differences in STI clinic use: a Dutch epidemiological study using aggregated STI clinic data combined with population numbers.

PubMed

van Oeffelen, A A M; van den Broek, I V F; Doesburg, M; Boogmans, B; Götz, H M; van Leeuwen-Voerman, F A M; van Veen, M G; Woestenberg, P J; van Benthem, B H B; van Steenbergen, J E

2017-02-01

Ethnic minorities (EM) from STI-endemic countries are at increased risk to acquire an STI. The objectives of this study were to investigate the difference in STI clinic consultation and positivity rates between ethnic groups, and compare findings between Dutch cities. Aggregated population numbers from 2011 to 2013 of 15-44 year-old citizens of Amsterdam, Rotterdam, The Hague and Utrecht extracted from the population register (N=3 129 941 person-years) were combined with aggregated STI clinic consultation data in these cities from the national STI surveillance database (N=113 536). Using negative binomial regression analyses (adjusted for age and gender), we compared STI consultation and positivity rates between ethnic groups and cities. Compared with ethnic Dutch (consultation rate: 40.3/1000 person-years), EM from Eastern Europe, Sub-Sahara Africa, Suriname, the Netherlands Antilles/Aruba and Latin America had higher consultation rates (range relative risk (RR): 1.27-2.26), whereas EM from Turkey, North Africa, Asia and Western countries had lower consultation rates (range RR: 0.29-0.82). Of the consultations among ethnic Dutch, 12.2% was STI positive. Positivity rates were higher among all EM groups (range RR: 1.14-1.81). Consultation rates were highest in Amsterdam and lowest in Utrecht independent of ethnic background (range RR Amsterdam vs Utrecht: 4.30-10.30). Positivity rates differed less between cities. There were substantial differences in STI clinic use between ethnic groups and cities in the Netherlands. Although higher positivity rates among EM suggest that these high-risk individuals reach STI clinics, it remains unknown whether their reach is optimal. Special attention should be given to EM with comparatively low consultation rates. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Objectively measured sedentary time among five ethnic groups in Amsterdam: The HELIUS study

PubMed Central

Nicolaou, Mary; Snijder, Marieke B.; Peters, Ron J. G.; Stronks, Karien; Langøien, Lars J.; van der Ploeg, Hidde P.; Brug, Johannes; Lakerveld, Jeroen

2017-01-01

Introduction Sedentary behaviour is increasingly recognised as a health risk. While differences in this behaviour might help explain ethnic differences in disease profiles, studies on sedentary behaviour in ethnic minorities are scarce. The aim of this study was to compare the levels and the socio-demographic and lifestyle-related correlates of objectively measured sedentary time among five ethnic groups in Amsterdam, the Netherlands. Methods Data were collected as part of the HELIUS study. The sample consisted of adults from a Dutch, Moroccan, African Surinamese, South-Asian Surinamese and Turkish ethnic origin. Data were collected by questionnaire, physical examination, and a combined heart rate and accelerometry monitor (Actiheart). Sedentary time was defined as waking time spent on activities of <1.5 metabolic equivalents. Ethnic differences in the levels of sedentary time were tested using ANOVA and ANCOVA analyses, while ethnic differences in the correlates of sedentary time were tested with interactions between ethnicity and potential correlates using general linear models. Associations between these correlates and sedentary time were explored using linear regression analyses stratified by ethnicity (pre-determined). All analyses were adjusted for gender and age. Results 447 participants were included in the analyses, ranging from 73 to 109 participants per ethnic group. Adjusted levels of sedentary time ranged from 569 minutes/day (9.5 hours/day) for participants with a Moroccan and Turkish origin to 621 minutes/day (10.3 hours/day) in African Surinamese participants. There were no statistically significant differences in the levels or correlates of sedentary time between the ethnic groups. Meeting the physical activity recommendations (150 minutes/week) was consistently inversely associated with sedentary time across all ethnic groups, while age was positively associated with sedentary time in most groups. Conclusions No statistically significant differences in the levels of objectively measured sedentary time or its socio-demographic and lifestyle-related correlates were observed among five ethnic groups in Amsterdam, the Netherlands. PMID:28759597

The role of Surinamese migrants in the transmission of Chlamydia trachomatis between Paramaribo, Suriname and Amsterdam, The Netherlands.

PubMed

Bom, Reinier J M; van der Helm, Jannie J; Bruisten, Sylvia M; Grünberg, Antoon W; Sabajo, Leslie O A; Schim van der Loeff, Maarten F; de Vries, Henry J C

2013-01-01

The large Surinamese migrant population in the Netherlands is a major risk group for urogenital Chlamydia trachomatis infection. Suriname, a former Dutch colony, also has a high prevalence of C. trachomatis. Surinamese migrants travel extensively between the Netherlands and Suriname. Our objective was to assess whether the Surinamese migrants in the Netherlands form a bridge population facilitating transmission of C. trachomatis between Suriname and the Netherlands. If so, joint prevention campaigns involving both countries might be required. Between March 2008 and July 2010, participants were recruited at clinics in Paramaribo, Suriname and in Amsterdam, the Netherlands. Participants were grouped as native Surinamese, native Dutch, Surinamese migrant, Dutch migrant, or Other, based on country of residence and country of birth of the participant and of their parents. Risk behavior, such as sexual mixing between ethnic groups, was recorded and C. trachomatis positive samples were typed through multilocus sequence typing (MLST). A minimum spanning tree of samples from 426 participants showed four MLST clusters. The MLST strain distribution of Surinamese migrants differed significantly from both the native Surinamese and Dutch populations, but was not an intermediate state between these two populations. Sexual mixing between the Surinamese migrants and the Dutch and Surinamese natives occurred frequently. Yet, the MLST cluster distribution did not differ significantly between participants who mixed and those who did not. Sexual mixing occurred between Surinamese migrants in Amsterdam and the native populations of Suriname and the Netherlands. These migrants, however, did not seem to form an effective bridge population for C. trachomatis transmission between the native populations. Although our data do not seem to justify the need for joint campaigns to reduce the transmission of C. trachomatis strains between both countries, intensified preventive campaigns to decrease the C. trachomatis burden are required, both in Suriname and in the Netherlands.

Fluorescent vancomycin and terephthalate comodified europium-doped layered double hydroxides nanoparticles: synthesis and application for bacteria labelling

NASA Astrophysics Data System (ADS)

Sun, Jianchao; Fan, Hai; Wang, Nan; Ai, Shiyun

2014-09-01

Vancomycin (Van)- and terephthalate (TA)-comodified europium-doped layered double hydroxides (Van-TA-Eu-LDHs) nanoparticles were successfully prepared by a two-step method, in which, TA acted as a sensitizer to enhance the fluorescent property and Van was modified on the surface of LDH to act as an affinity reagent to bacteria. The obtained products were characterized by X-ray diffraction, transmission electron microscope and fluorescent spectroscopy. The results demonstrated that the prepared Van- and TA-comodified europium-doped layered double hydroxides (Van-TA-Eu-LDHs) nanoparticles with diameter of 50 nm in size showed highly efficient fluorescent property. Furthermore, due to the high affinity of Van to bacteria, the prepared Van-TA-Eu-LDHs nanoparticles showed efficient bacteria labelling by fluorescent property. The prepared nanoparticles may have wide applications in the biological fields, such as biomolecular labelling and cell imaging.

Defending commercial surrogate motherhood against Van Niekerk and Van Zyl.

PubMed Central

McLachlan, H V

1997-01-01

The arguments of Van Niekerk and Van Zyl that, on the grounds that it involves an inappropriate commodification and alienation of women's labour, commercial surrogate motherhood (CSM) is morally suspect are discussed and considered to be defective. In addition, doubt is cast on the notion that CSM should be illegal. PMID:9451602

Alternative Fuels Data Center: Renzenberger Inc Saves Money With Propane

Science.gov Websites

Vans Renzenberger Inc Saves Money With Propane Vans to someone by E-mail Share Alternative Fuels Data Center: Renzenberger Inc Saves Money With Propane Vans on Facebook Tweet about Alternative Fuels Data Center: Renzenberger Inc Saves Money With Propane Vans on Twitter Bookmark Alternative Fuels

77 FR 44683 - Phillips-Van Heusen Corporation, IZOD Dress Furnishings Division, New York, NY; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... for Reconsideration for the workers and former workers of Phillips-Van Heusen Corporation, IZOD Women... Phillips-Van Heusen Corporation, IZOD Women's Wholesale Division, New York, New York has not increased. In... Phillips-Van Heusen Corporation, IZOD Women's Wholesale Division, New York, New York) was incorrect, that...

15 CFR 30.26 - Reporting of vessels, aircraft, cargo vans, and other carriers and containers.

Code of Federal Regulations, 2014 CFR

2014-01-01

... vehicles, trailers, pallets, cargo vans, lift vans, or similar shipping containers are not considered... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Reporting of vessels, aircraft, cargo vans, and other carriers and containers. 30.26 Section 30.26 Commerce and Foreign Trade Regulations...

15 CFR 30.26 - Reporting of vessels, aircraft, cargo vans, and other carriers and containers.

Code of Federal Regulations, 2012 CFR

2012-01-01

... vehicles, trailers, pallets, cargo vans, lift vans, or similar shipping containers are not considered... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Reporting of vessels, aircraft, cargo vans, and other carriers and containers. 30.26 Section 30.26 Commerce and Foreign Trade Regulations...

15 CFR 30.26 - Reporting of vessels, aircraft, cargo vans, and other carriers and containers.

Code of Federal Regulations, 2013 CFR

2013-01-01

... vehicles, trailers, pallets, cargo vans, lift vans, or similar shipping containers are not considered... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Reporting of vessels, aircraft, cargo vans, and other carriers and containers. 30.26 Section 30.26 Commerce and Foreign Trade Regulations...

15 CFR 30.26 - Reporting of vessels, aircraft, cargo vans, and other carriers and containers.

Code of Federal Regulations, 2010 CFR

2010-01-01

... vehicles, trailers, pallets, cargo vans, lift vans, or similar shipping containers are not considered... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Reporting of vessels, aircraft, cargo vans, and other carriers and containers. 30.26 Section 30.26 Commerce and Foreign Trade Regulations...

15 CFR 30.26 - Reporting of vessels, aircraft, cargo vans, and other carriers and containers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... vehicles, trailers, pallets, cargo vans, lift vans, or similar shipping containers are not considered... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Reporting of vessels, aircraft, cargo vans, and other carriers and containers. 30.26 Section 30.26 Commerce and Foreign Trade Regulations...

UPS Hybrid Electric Delivery Van Testing | Transportation Research | NREL

Science.gov Websites

conventional diesel vans. Publications The following documents provide detailed information about the study the conventional vans during the on-road portion of the study. The two vehicle groups switched route assignments during the study period to provide a balanced review of the vans on the same routes. During

Probing the binding of phenolic aldehyde vanillin with bovine serum albumin: Evidence from spectroscopic and docking approach.

PubMed

Siddiqui, Gufran Ahmed; Siddiqi, Mohammad Khursheed; Khan, Rizwan Hasan; Naeem, Aabgeena

2018-05-08

The interactions of bovine serum albumin (BSA) with vanillin (VAN) were studied using UV-vis absorption, fluorescence, synchronous fluorescence, three dimensional fluorescence spectroscopy (3D), Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), and molecular docking techniques. The results revealed that VAN causes the static quenching of BSA by forming BSA-VAN complex. The thermodynamic parameters obtained using isothermal titration calorimetry (ITC) showed that the interaction between BSA and VAN is spontaneous and hydrogen bonding, van der Waals forces are mainly involved in stabilizing the complex. The distance between the donor and the acceptor was analyzed using fluorescence resonance energy transfer (FRET) which showed Forster distance of 2.58 nm. Molecular docking technique was applied to study the modes of interaction between BSA-VAN system and it was found that VAN bound to the sub-domain IIA of BSA. Structural analysis using 3D, synchronous fluorescence FTIR, and CD showed that upon binding of VAN, BSA exhibits small micro-environmental changes around tryptophan amino acid residue. Copyright © 2018. Published by Elsevier B.V.

Relationship of the Van Herick Grading System with Peripheral Iris Configuration and Level of Iris Insertion.

PubMed

Khan, Faisal Aziz; Niazi, Shafaq Pervez Khan; Khan, Assad Zaman

2017-09-01

To determine the relationship of the van Herick angle grading system with the level of iris insertion and peripheral iris configuration. Observational study. Eye department, Combined Military Hospital, Malir Cantt., Karachi, from May to October 2015. Sixty-five eyes of 65 patients were recruited. Anterior chamber depth at the temporal limbus was measured as a fraction of corneal section thickness using van Herick technique and graded on the standard 4-point scale of the van Herick grading system. Gonioscopy of the temporal quadrant was performed with a Posner 4 mirror goniolens and both the true level of iris insertion and peripheral iris configuration were recorded on a 4-point scale so as to equate with the van Herick 4-point grading system. Spearman's rho test was applied to determine the relationship of the van Herick grading system with level of iris root insertion and peripheral iris configuration. Amoderate positive correlation between van Herick grade and peripheral iris configuration was found which was statistically significant (rs=0.42, p < 0.001). Astatistically significant and moderate positive correlation was also detected between van Herick grade and the level of iris insertion (rs=0.45, p < 0.001). The van Herick grade has a moderately positive relationship with the peripheral iris configuration and true level of iris insertion.

Transcriptional Analysis of the vanC Cluster from Enterococcus gallinarum Strains with Constitutive and Inducible Vancomycin Resistance

PubMed Central

Panesso, Diana; Abadía-Patiño, Lorena; Vanegas, Natasha; Reynolds, Peter E.; Courvalin, Patrice; Arias, Cesar A.

2005-01-01

The vanC glycopeptide resistance gene cluster encodes enzymes required for synthesis of peptidoglycan precursors ending in d-Ala-d-Ser. Enterococcus gallinarum BM4174 and SC1 are constitutively and inducibly resistant to vancomycin, respectively. Analysis of peptidoglycan precursors in both strains indicated that UDP-MurNAc-tetrapeptide and UDP-MurNAc-pentapeptide[d-Ser] were synthesized in E. gallinarum SC1 only in the presence of vancomycin (4 μg/ml), whereas the “resistance” precursors accumulated in the cytoplasm of BM4174 cells under both inducing and noninducing conditions. Northern hybridization and reverse transcription-PCR experiments revealed that all the genes from the cluster, vanC-1, vanXYC, vanT, vanRC, and vanSC, were transcribed from a single promoter. In the inducible SC1 isolate, transcriptional regulation appeared to be responsible for inducible expression of resistance. Promoter mapping in E. gallinarum BM4174 revealed that the transcriptional start site was located 30 nucleotides upstream from vanC-1 and that the −10 promoter consensus sequence had high identity with that of the vanA cluster. Comparison of the deduced sequence of the vanSC genes from isolates with constitutive and inducible resistance revealed several amino acid substitutions located in the X box (R200L) and in the region between the F and G2 boxes (D312N, D312A, and G320S) of the putative sensor kinase proteins from isolates with constitutive resistance. PMID:15728903

Heterologous expression of glycopeptide resistance vanHAX gene clusters from soil bacteria in Enterococcus faecalis.

PubMed

Hasman, Henrik; Aarestrup, Frank M; Dalsgaard, Anders; Guardabassi, Luca

2006-04-01

The aim of the study was to determine whether glycopeptide resistance gene clusters from soil bacteria could be heterologously expressed in Enterococcus faecalis and adapt to the new host following exposure to vancomycin. The vanHAX clusters from Paenibacillus thiaminolyticus PT-2B1, Paenibacillus apiarius PA-B2B and Amycolatopsis coloradensis DSM 44225 were separately cloned in an appropriately constructed shuttle vector containing the two-component regulatory system (vanRS) of Tn1546. The complete vanA(PT) operon (vanRSHAXY) from P. thiaminolyticus PT-2B1 was cloned in the same shuttle vector lacking enterococcal vanRS. All plasmid constructs were electroporated into E. faecalis JH2-2 and the MICs of vancomycin and teicoplanin were determined for each recombinant strain before and following exposure to sublethal concentrations of vancomycin. The vanHAX clusters from P. thiaminolyticus and P. apiarius conferred high-level vancomycin resistance (MIC > or = 125 mg/L) in E. faecalis JH2-2. In contrast, cloning of the vanHAX cluster from A. coloradensis did not result in a significant increase of vancomycin resistance (MIC = 0.7 mg/L). Resistance to vancomycin was not observed after cloning the complete vanA(PT) operon from P. thiaminolyticus (MIC = 2 mg/L), but this recombinant rapidly adapted to high concentrations of vancomycin (MIC = 500 mg/L) following exposure to sub-lethal concentrations of this antibiotic. The results showed that vanA(PT) in P. thiaminolyticus is a possible ancestor of vanA-mediated glycopeptide resistance in enterococci. Experimental evidence supported the hypothesis that enterococci did not acquire glycopeptide resistance directly from glycopeptide-producing organisms such as A. coloradensis.

Comparison of Six Generic Vancomycin Products for Treatment of Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis in Rabbits

PubMed Central

Tattevin, P.; Saleh-Mghir, A.; Davido, B.; Ghout, I.; Massias, L.; Garcia de la Maria, C.; Miró, J. M.; Perronne, C.; Laurent, F.

2013-01-01

Concerns have recently emerged about the potency and the quality of generic vancomycin (VAN) products approved for use in humans, based on experiments in a neutropenic mouse thigh infection model. However, other animal models may be more appropriate to decipher the bactericidal activities of VAN generics in vivo and to predict their efficacy in humans. We aimed to compare the bactericidal activities of six generic VAN products currently used in France (Mylan and Sandoz), Spain (Hospira), Switzerland (Teva), and the United States (Akorn-Strides and American Pharmaceutical Products [APP]) in a rabbit model of aortic valve endocarditis induced by 8 × 107 CFU of methicillin-resistant Staphylococcus aureus (MRSA) strain COL (VAN MIC, 1.5 μg/ml). In vitro, there were no significant differences in the time-kill curve studies performed with the six generic VAN products. Ten rabbits in each group were treated with intravenous (i.v.) VAN, 60 mg/kg of body weight twice a day (b.i.d.) for 4 days. Mean peak serum VAN levels, measured 45 min after the last injection, ranged from 35.5 (APP) to 45.9 μg/ml (Teva). Mean trough serum VAN levels, measured 12 h after the last injection, ranged from 2.3 (Hospira) to 9.2 (APP) μg/ml. All generic VAN products were superior to controls (no treatment) in terms of residual organisms in vegetations (P < 0.02 for each comparison) and in the spleen (P < 0.005 for each comparison). Pairwise comparisons of generic VAN products found no significant differences. In conclusion, a stringent MRSA endocarditis model found no significant differences in the bactericidal activities of six generic VAN products currently used in Europe and America. PMID:23254435

Experimental Compressibility of Molten Hedenbergite at High Pressure

NASA Astrophysics Data System (ADS)

Agee, C. B.; Barnett, R. G.; Guo, X.; Lange, R. A.; Waller, C.; Asimow, P. D.

2010-12-01

Experiments using the sink/float method have bracketed the density of molten hedenbergite (CaFeSi2O6) at high pressures and temperatures. The experiments are the first of their kind to determine the compressibility of molten hedenbergite at high pressure and are part of a collaborative effort to establish a new database for an array of silicate melt compositions, which will contribute to the development of an empirically based predictive model that will allow calculation of silicate liquid density and compressibility over a wide range of P-T-X conditions where melting could occur in the Earth. Each melt composition will be measured using: (i) double-bob Archimedean method for melt density and thermal expansion at ambient pressure, (ii) sound speed measurements on liquids to constrain melt compressibility at ambient pressure, (iii) sink/float technique to measure melt density to 15 GPa, and (iv) shock wave measurements of P-V-E equation of state and temperature between 10 and 150 GPa. Companion abstracts on molten fayalite (Waller et al., 2010) and liquid mixes of hedenbergite-diopside and anorthite-hedenbergite-diopside (Guo and Lange, 2010) are also presented at this meeting. In the present study, the hedenbergite starting material was synthesized at the Experimental Petrology Lab, University of Michigan, where melt density, thermal expansion, and sound speed measurements were also carried out. The starting material has also been loaded into targets at the Caltech Shockwave Lab, and experiments there are currently underway. We report here preliminary results from static compression measurement performed at the Department of Petrology, Vrije Universiteit, Amsterdam, and the High Pressure Lab, Institute of Meteoritics, University of New Mexico. Experiments were carried out in Quick Press piston-cylinder devices and a Walker-style multi-anvil device. Sink/float marker spheres implemented were gem quality synthetic forsterite (Fo100), San Carlos olivine (Fo90), and natural pyropic garnet(Pyr74 Alm13.5 Gro12.5). We bracketed the density of molten hedenbergite with Fo100 to be 3.09 g cm-3 at 1.1 GPa and 1450°C, and with Fo90 to be 3.27 g cm-3 at 3.0 GPa and 1450-1550°C. These sink-float values represent an increase in isothermal density from reference ambient pressure of 6% and 12% respectively, or linear compressions of 0.16 and 0.12 g cm-3 GPa-1. The density-with-pressure increases in our static compression experiments are in good agreement with the Michigan ambient pressure sound speed measurements that yield an isentropic bulk modulus of KS=18.77 GPa. Currently we are performing higher pressure sink/float experiments in the range 7-8 GPa with pyrope garnet marker spheres to better constrain values for the isothermal bulk modulus (KT) and its pressure derivative K'. As a by-product of our sink/float experiments we are also determining the melting curve of hedenbergite well beyond the published pressure extent of approximately 1.5 GPa (Lindsley, 1967). Our early data show the hedenbergite liquidus to be 1450°C at 3 GPa and approximately 1750°C at 7 GPa.

New taxa, including three new genera show uniqueness of Neotropical Nepticulidae (Lepidoptera)

PubMed Central

van Nieukerken, Erik J.; Doorenweerd, Camiel; Nishida, Kenji; Snyers, Chris

2016-01-01

Abstract After finding distinct clades in a molecular phylogeny for Nepticulidae that could not be placed in any known genera and discovering clear apomorphic characters that define these clades, as well as a number of Neotropical species that could be placed in known genera but were undescribed, three new genera and nine new species are here described from the Neotropics: Stigmella gallicola van Nieukerken & Nishida, sp. n. reared from galls on Hampea appendiculata (Malvaceae) in Costa Rica, representing the first example of a gall making Stigmella; Stigmella schinivora van Nieukerken, sp. n. reared from leafmines on Schinus terebinthifolia (Anacardiaceae) in Argentina, Misiones; Stigmella costaricensis van Nieukerken & Nishida, sp. n. and Stigmella intronia van Nieukerken & Nishida, sp. n. each from a single specimen collected the same night in Costa Rica, Parque Nacional Chirripó; Stigmella molinensis van Nieukerken & Snyers, sp. n. reared from leafmines on Salix humboldtiana, Peru, Lima, the first Neotropical species of the Stigmella salicis group sensu stricto; Ozadelpha van Nieukerken, gen. n. with type species Ozadelpha conostegiae van Nieukerken & Nishida, sp. n., reared from leafmines on Conostegia oerstediana (Melastomataceae) from Costa Rica; Neotrifurcula van Nieukerken, gen. n. with type species Neotrifurcula gielisorum van Nieukerken, sp. n. from Chile; Hesperolyra van Nieukerken, gen. n.. with type species Fomoria diskusi Puplesis & Robinson, 2000; Hesperolyra saopaulensis van Nieukerken, sp. n., reared from an unidentified Myrtaceae, Sao Paulo, Brasil; and Acalyptris janzeni van Nieukerken & Nishida, sp. n. from Costa Rica, Guanacaste. Five new combinations are made: Ozadelpha ovata (Puplesis & Robinson, 2000), comb. n. and Ozadelpha guajavae (Puplesis & Diškus, 2002), comb. n., Hesperolyra diskusi (Puplesis & Robinson, 2000), comb. n., Hesperolyra molybditis (Zeller, 1877), comb. n. and Hesperolyra repanda (Puplesis & Diškus, 2002), comb. n. Three specimens are briefly described, but left unnamed: Ozadelpha specimen EvN4680, Neotrifurcula specimen EvN4504 and Neotrifurcula specimen RH2. PMID:27917037

Do apolipoprotein E genotype and educational attainment predict the rate of cognitive decline in normal aging? A 12-year follow-up of the Maastricht Aging Study.

PubMed

Van Gerven, Pascal W M; Van Boxtel, Martin P J; Ausems, Eleonora E B; Bekers, Otto; Jolles, Jelle

2012-07-01

We investigated suspected longitudinal interaction effects of apolipoprotein E (APOE) genotype and educational attainment on cognitive decline in normal aging. Our sample consisted of 571 healthy, nondemented adults aged between 49 and 82 years. Linear mixed-models analyses were performed with four measurement time points: baseline, 3-year, 6-year, and 12-year follow-up. Covariates included age at baseline, sex, and self-perceived physical and mental health. Dependent measures were global cognitive functioning (Mini-Mental State Examination; Folstein, Folstein, & McHugh, 1975), Stroop performance (Stroop Color-Word Test; Van der Elst, Van Boxtel, Van Breukelen, & Jolles, 2006a), set-shifting performance (Concept Shifting Test; Van der Elst, Van Boxtel, Van Breukelen, & Jolles, 2006b), cognitive speed (Letter-Digit Substitution Test; Van der Elst, Van Boxtel, Van Breukelen, & Jolles, 2006c), verbal learning (Verbal Learning Test: Sum of five trials; Van der Elst, Van Boxtel, Van Breukelen, & Jolles, 2005), and long-term memory (Verbal Learning Test: Delayed recall). We found only faint evidence that older, high-educated carriers of the APOE-ε4 allele (irrespective of zygosity) show a more pronounced decline than younger, low-educated carriers and noncarriers (irrespective of educational attainment). Moreover, this outcome was confined to concept-shifting performance and was especially observable between 6- and 12-year follow-ups. No protective effects of higher education were found on any of the six cognitive measures. We conclude that the combination of APOE-ε4 allele and high educational attainment may be a risk factor for accelerated cognitive decline in older age, as has been reported before, but only to a very limited extent. Moreover, we conclude that, within the cognitive reserve framework, education does not have significant protective power against age-related cognitive decline.

Vancomycin resistant Enterococcus spp. from crows and their environment in metropolitan Washington State, USA: Is there a correlation between VRE positive crows and the environment?

PubMed

Roberts, Marilyn C; No, David B; Marzluff, John M; Delap, Jack H; Turner, Robert

2016-10-15

Vancomycin-resistant enterococci [VRE] have been isolated from municipal, hospital and agricultural wastewater, recreational beaches, wild animals, birds and food animals around the world. In this study, American crows (Corvus brachyrhynchos) from sewage treatment plants (WWTP), dairy farms, and a large roost in a restored wetland with corresponding environmental samples were cultured for VRE. A total of 245 samples [156 crows, 89 environmental] were collected and screened for acquired vanA, vanB and/or intrinsic vanC1 genes. Samples were enriched overnight in BHI supplemented with 20μg/mL aztreonam, 4μg/mL vancomycin and plated on m-Enterococcus agar media supplemented with 6μg/mL vancomycin. Selected colonies were grown on BHI media supplemented with 18μg/mL vancomycin. Of these, 24.5% of the crow and 55% the environmental/cow samples were VRE positive as defined by Enterococcus spp. able to grow on media supplemented with 18μg/mL vancomycin. A total of 122 VRE isolates, 43 crow and 79 environmental isolates were screened, identified to species level using 16S sequencing and further characterized. Four vanA E. faecium and multiple vanC1 E. gallinarum were identified from crows isolated from three sites. E. faecium vanA and E. gallinarum vanC1 along with other Enterococcus spp. carrying vanA, vanB, vanC1 were isolated from three environments. All enterococci were multidrug resistant. Crows were more likely to carry vanA E. faecium than either the cow feces or wetland waters/soils. Comparing E. gallinarum vanC1 from crows and their environment would be useful in determining whether crows share VRE strains with their environment. Copyright © 2016 Elsevier B.V. All rights reserved.

Computer Simulation of the Effect of Pretreatment with Reversible Acetylcholinesterase Inhibitors on the Protection Against Soman Poisoning

DTIC Science & Technology

1993-12-01

dr. U.A. Th. Brinkmnan 31* Directeur van het Medisch Biologisch Laboratorium TNO Prof. dr. W.R.F. Notten 32 PML-TNO, Directeur; daarna reserve 33 PML...Generaal Personeel Ministerie van Defensie 8* Adviseur van het Prins Maurits Laboratorium TNO Chemnische Research Prof. dr. G. Dijkstra 9* lid van de

Alternative Fuels Data Center: Natural Gas Delivery Vans Support McShan

Science.gov Websites

FloristA> Natural Gas Delivery Vans Support McShan Florist to someone by E-mail Share Alternative Natural Gas Delivery Vans Support McShan Florist Watch how a Dallas, Texas, florist reduces emissions and saves money fueling delivery vans with compressed natural gas. For information about this project

Ex ante Implementatietoetsing van Beleid, Een Methodiek Gebaseerd op Synergie Tussen Risicomanagement en Verandermanagement (Ex Ante Test for Policy Implementation - A Method Based Upon Synergy Between Risk Management an Change Management)

DTIC Science & Technology

2006-12-01

ante implementatietoetsing van beleid Een methodiek gebaseerd op synergie tussen risicomnanagemnent en verandermanagemnent Datuni december 2006 Auteur (s...te analyseren. Het de resultaten van de interviews gebruikct bij de theorie van risicomanagement en project Verandermanagernent bij de de ontwikkehing...Opdrachtnummer Hoewel expliciet is gekeken naar voorbeelden van risico’s bij Datum december 2006 Auteur (s) PROGRAMMA PR03ECT drs. R.C.T. de Haas drs

Waardering en Analyse van Simulatieresultaten (Valuation and Analysis of Simulation Results)

DTIC Science & Technology

1991-12-01

is uit de tabel van de Students T-verdeling te halen . Deze wordt aangeduid met t,(v), waarin a de overschrijdingskans en v bet aantal vrijheidsgraden...2 vrijheidsgraden. Uit de tabol van de Student’s t-verdeling zija nu de kritieke waardon R, on R2 to halen zodanig dat P(t >R2 ) = i Wordt or eon...analyse van simnulatieresultaten - TDCnaK RAPPORTE1CENTRALE Frederikkazerne, Geb. 140 AD-A25 470van den Burchlaan 31AD-A25 470Telefoon: 070-3166394

Novel type of VanB2 teicoplanin-resistant hospital-associated Enterococcus faecium.

PubMed

Santona, Antonella; Paglietti, Bianca; Al-Qahtani, Ahmed A; Bohol, Marie Fe F; Senok, Abiola; Deligios, Massimo; Rubino, Salvatore; Al-Ahdal, Mohammed N

2014-08-01

Seven high-risk clones of vancomycin-resistant Enterococcus faecium (VREF) belonging to clonal complex 17 were identified using multilocus sequence typing (MLST) among clinical isolates from Saudi Arabia. Among these isolates, a new hospital-associated sequence type (ST795), VanB(2)-type teicoplanin-resistant strain was detected. Its unusual phenotype resulted from a new combination of mutations in the ddl, vanS and vanW genes, which confirmed the trend of evolution in VanB-type resistance. Furthermore, characteristics of adaptation and persistence in the hospital environment of ST795 were emphasised by the presence of genes and clusters recognised to be specific for hospital-associated VREF. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

76 FR 19788 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Telemanagement Forum

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

...Telematics, Inc., Atlanta, GA; Inducta d.o.o., Zagreb, CROATIA; Infinite Infosoft Services Pvt Ltd, Gurgaon, INDIA; ING Bank N.V., Amsterdam, NETHERLANDS; integracija od-do d.o.o., Zagreb, CROATIA; Intraway Corp...; HughesTelematics to HughesTelematics, Inc., Atlanta, GA; Inducta to Inducta d.o.o., Zagreb, CROATIA...

Data Use Agreement | Office of Cancer Clinical Proteomics Research

Cancer.gov

CPTAC requests that data users abide by the same principles that were previously established in the Fort Lauderdale and Amsterdam meetings. The recommendations from the Fort Lauderdale meeting (2003) on best practices and principles for sharing large-scale genomic data address the roles and responsibilities of data producers, data users and funders of community resource projects.

The Relation between Specialty Choice of Psychology Students and Their Interests, Personality, and Cognitive Abilities

ERIC Educational Resources Information Center

Wicherts, Jelte M.; Vorst, Harrie C. M.

2010-01-01

The aim of this longitudinal study was to investigate differences in interests, personality, and cognitive abilities between students majoring in the six specialties of psychology at the University of Amsterdam. Results show that students at Social Psychology and Work and Organizational Psychology were on average more extraverted than students of…

Racialized Classroom Practices in a Diverse Amsterdam Primary School: The Silencing, Disparagement, and Discipline of Students of Color

ERIC Educational Resources Information Center

Weiner, Melissa F.

2016-01-01

In both Europe and the US, racial and ethnic minority students experience discrimination at the hands of teachers that negatively impacts academic achievement. In the US, scholars have documented how a predominantly white teaching force racializes students of color through discipline and low expectations, which impact educational attainment. But…

76 FR 76436 - Certain Communication Equipment, Components Thereof, and Products Containing the Same, Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-07

... Rule 210.50(b)(1), 19 CFR 210.50(b)(1), the presiding administrative law judge shall take evidence or...: Cisco Systems, Inc., 170 West Tasman Drive, San Jose, CA 95134. Cisco Consumer Products LLC, 120 Theory... CH, Amsterdam, Netherlands. Cisco-Linksys LLC, 121 Theory Drive, Irvine, CA 92617. Hewlett-Packard Co...

Using a Web Application to Conduct and Investigate Syntheses of Methyl Orange Remotely

ERIC Educational Resources Information Center

van Rens, Lisette; van Dijk, Hans; Mulder, Jan; Nieuwland, Pieter

2013-01-01

Thirty-six pre-university chemistry students and two chemistry teachers used flow chemistry as a technology for the synthesis of methyl orange. FutureChemistry and VU University Amsterdam cooperatively created FlowStart Remote, a device that enabled the students to remotely conduct this synthesis and in real time monitor and control the device via…

Storification in History Education: A Mobile Game in and about Medieval Amsterdam

ERIC Educational Resources Information Center

Akkerman, Sanne; Admiraal, Wilfried; Huizenga, Jantina

2009-01-01

A mobile and multimedia game designed for History education was analyzed in terms of how it is designed and how it was applied as a narrative learning environment. In History education, narrative can be argued to be very useful to overcome fragmentation of the knowledge of historical characters and events, by relating these with meaningful…

Increase in Spin Injection Efficiency of a CoFe/MgO (100) Tunnel Spin Injector with Thermal Annealing

DTIC Science & Technology

2005-01-24

geometry, the optical selection rules provide a direct correlation between the EL polarization and the spin polarization of the electrons just prior...Holland, Amsterdam, 1984d. 18M. Gurioli, A. Vinattieri, M. Colocci, C. Deparis, J. Massies, G. Neu, A. Bosacchi, and S. Franchi , Phys. Rev. B 44, 3115

Kabbalah, Education, and Prayer: Jewish Learning in the Seventeenth Century

ERIC Educational Resources Information Center

Necker, Gerold

2018-01-01

In the seventeenth century, the Jewish mystical tradition which is known as Kabbalah was integrated into the curriculum of studying the Hebrew Bible and the Talmud. Kabbalah became popular in these times in the wake of the dissemination of Isaac Luria's teachings, in particular within the Jewish communities in Prague and Amsterdam, where members…

Environmental Education Excursions and Proximity to Urban Green Space--Densification in a "Compact City"

ERIC Educational Resources Information Center

Wolsink, Maarten

2016-01-01

The value of urban green space for environmental education fieldwork is empirically investigated in a study among all secondary schools in Amsterdam. The article describes how the proximity of schools to green spaces emerges as a new factor in the "sustainable city" and the "compact city" debate. For fieldwork excursions…

The Fourteenth International Meeting on Time-Resolved Vibrational Spectroscopy (TRVS XIV)

DTIC Science & Technology

2010-02-03

Technology United States ahorning@mit.edu Anne Hudson MIT Dept. of Chemistry United States amh@mit.edu Adriana Huerta Viga University of Amsterdam...Hoffmann, Janos Hebling, Harold Y. Hwang, THz-pump/THz-probe nonlinear spectroscopy Ka -Lo Yeh, Keith A. Nelson, MIT 11:30 AM C Tomonori Nomoto and

GRAPPA Trainees Symposium 2017: A Report from the GRAPPA 2017 Annual Meeting.

PubMed

Furer, Victoria; Manasson, Julia; Boehncke, Wolf-Henning; Ritchlin, Christopher T

2018-06-01

At the 2017 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) in Amsterdam, the Netherlands, a trainees symposium was held. Rheumatology and dermatology trainees engaged in psoriasis or psoriatic arthritis research presented their work. This report briefly reviews 6 oral presentations and 25 posters presented at the meeting.

In Vivo Fluorescence Confocal Microscopy to Investigate the Role of RhoC in Inflammatory Breast Cancer

DTIC Science & Technology

2005-11-01

5084. 6. Colpaert CG, Vermeulen PB, Benoy I, Soubry A, van Roy F, van Beest P, Goovaerts G, Dirix LY, van Dam P, Fox SB, Harris AL, van MarckEA...small GTPases, RhoA and RhoC, is associ- inflammatory breast cancer. Clin Exp Metastasis 2002, ated with tumor progression in ovarian carcinoma. Lab

The Use of ICT to Support Students with Dyslexia

NASA Astrophysics Data System (ADS)

Diraä, Nadia; Engelen, Jan; Ghesquière, Pol; Neyens, Koen

The Katholieke Universiteit Leuven (K.U.Leuven) has a tradition of supporting students with a disability in order to guarantee equal opportunities to achieve their educational, personal and vocational goals. The K.U.Leuven policy is working towards inclusive education in the long term, by improving facilities and accommodation for certain target groups in the short term. Efforts have also been directed to make the learning environment more accessible for all kind of students, especially over the last few years. One of the target groups that has increasing numbers are students with learning disabilities (including dyslexia, dyscalculia, ...). To accommodate these students, the K.U.Leuven set off a project to evaluate the use of assistive technology (AT) for dyslexia. This small-scale study examined the experiences of two groups of students with dyslexia using 2 different software programs specifically developed to support this group of students. It was apparent that for students with dyslexia, reading and studying presents additional limitations which AT could facilitate to some extent.

Electromagnetic DM technology meets future AO demands

NASA Astrophysics Data System (ADS)

Hamelinck, Roger; Rosielle, Nick; Steinbuch, Maarten; Doelman, Niek

New deformable mirror technology is developed by the Technische Universiteit Eindhoven, Delft University of Technology and TNO Science and Industry. Several prototype adaptive deformable mirrors are realized mirrors, up to 427 actuators and ∅150mm diameter, with characteristics suitable for future AO systems. The prototypes consist of a 100µm thick, continuous facesheet on which low voltage, electromagnetic, push-pull actuators impose out-of-plane displacements. The variable reluctance actuators with ±10µm stroke and nanometer resolution are located in a standard actuator module. Each module with 61 actuators connects to a single PCB with dedicated, 16 bit, PWM based, drivers. A LVDS multi-drop cable connects up to 32 actuator modules. With the actuator module, accompanying PCB and multi-drop system the deformable mirror technology is made modular in its mechanics and electronics. An Ethernet-LVDS bridge enables any commercial PC to control the mirror using the UDP standard. Latest results of the deformable mirror technology development are presented.

Design and mechanistic study of a novel gold nanocluster-based drug delivery system.

PubMed

Li, Qinzhen; Pan, Yiting; Chen, Tiankai; Du, Yuanxin; Ge, Honghua; Zhang, Buchang; Xie, Jianping; Yu, Haizhu; Zhu, Manzhou

2018-05-22

Chemically-triggered drug delivery systems (DDSs) have been extensively studied as they do not require specialized equipment to deliver the drug and can deeply penetrate human tissue. However, their syntheses are complicated and they tend to be cytotoxic, which restricts their clinical utility. In this work, the self-regulated drug loading and release capabilities of peptide-protected gold nanoclusters (Pep-Au NCs) are investigated using vancomycin (Van) as the model drug. Gold nanoclusters (Au NCs) coated with a custom-designed pentapeptide are synthesized as drug delivery nanocarriers and loaded with Van - a spontaneous process reliant on the specific binding between Van and the custom-designed peptide. The Van-loaded Au NCs show comparable antimicrobial activity with Van on its own, and the number of Van released by the Pep-Au NCs is found to be proportional to the amount of bacteria present. The controlled nature of the Van release is very encouraging, and predominantly due to the stronger binding affinity of Van with bacteria than that with Au NCs. In addition, these fluorescent Au NCs could also be used to construct temperature sensors, which enable the in vitro and in vivo bioimaging.

Vanilla mosaic virus isolates from French Polynesia and the Cook Islands are Dasheen mosaic virus strains that exclusively infect vanilla.

PubMed

Farreyrol, K; Pearson, M N; Grisoni, M; Cohen, D; Beck, D

2006-05-01

Sequence was determined for the coat protein (CP) gene and 3' non-translated region (3'NTR) of two vanilla mosaic virus (VanMV) isolates from Vanilla tahitensis, respectively from the Cook Islands (VanMV-CI) and French Polynesia (VanMV-FP). Both viruses displayed distinctive features in the N-terminal region of their CPs; for VanMV-CI, a 16-amino-acid deletion including the aphid transmission-related DAG motif, and for VanMV-FP, a stretch of GTN repeats that putatively belongs to the class of natively unfolded proteins. VanMV-FP CP also has a novel DVG motif in place of the DAG motif, and an uncommon Q//V protease cleavage site. The sequences were compared to a range of Dasheen mosaic virus (DsMV) strains and to potyviruses infecting orchids. Identity was low to DsMV strains across the entire CP coding region and across the 3'NTR, but high across the CP core and the CI-6K2-NIa region. In accordance with current ICTV criteria for species demarcation within the family Potyviridae, VanMV-CI and VanMV-FP are strains of DsMV that exclusively infect vanilla.

Van der waals forces on thin liquid films in capillary tubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herdt, G.C.; Swanson, L.W.

1993-10-01

A theory of the van der Waals attraction between a thin liquid films and a capillary tube is presented assuming the presence of a vapor-liquid interface. The model is based on the surface mode analysis method of van Kampen et al. Values for the van der Waals interaction energy per unit area were calculated for liquid films of pentane on a gold substrate assuming a thin liquid film. Results indicate that the effect of capillary curvature on the van der Waals interaction increases as the ratio of the liquid film thickness to the capillary radius is increased. This trend ismore » consistent with predictions based on the Hamaker theory. Deviations from results based on the Hamaker theory are easily explained in terms of retardation of the van der Waals interaction. Because the effect of capillary curvature increases in the regime where retardation effects become important, curvature effects constitute a small correction to the van der Waals forces in a capillary tube.« less

Accuracy of the VITEK 2 System To Detect Glycopeptide Resistance in Enterococci

PubMed Central

van den Braak, Nicole; Goessens, Wil; van Belkum, Alex; Verbrugh, Henri A.; Endtz, Hubert P.

2001-01-01

We evaluated the accuracy of the VITEK 2 fully automated system to detect and identify glycopeptide-resistant enterococci (GRE) compared to a reference agar dilution method. The sensitivity of vancomycin susceptibility testing with VITEK 2 for the detection of vanA, vanB, and vanC1 strains was 100%. The sensitivity of vancomycin susceptibility testing of vanC2 strains was 77%. The sensitivity of teicoplanin susceptibility testing of vanA strains was 90%. Of 80 vanC enterococci, 78 (98%) were correctly identified by VITEK 2 as Enterococcus gallinarum/Enterococcus casseliflavus. Since the identification and susceptibility data are produced within 3 and 8 h, respectively, VITEK 2 appears a fast and reliable method for detection of GRE in microbiology laboratories. PMID:11136798

First complete genome sequence of vanilla mosaic strain of Dasheen mosaic virus isolated from the Cook Islands.

PubMed

Puli'uvea, Christopher; Khan, Subuhi; Chang, Wee-Leong; Valmonte, Gardette; Pearson, Michael N; Higgins, Colleen M

2017-02-01

We present the first complete genome of vanilla mosaic virus (VanMV). The VanMV genomic structure is consistent with that of a potyvirus, containing a single open reading frame (ORF) encoding a polyprotein of 3139 amino acids. Motif analyses indicate the polyprotein can be cleaved into the expected ten individual proteins; other recognised potyvirus motifs are also present. As expected, the VanMV genome shows high sequence similarity to the published Dasheen mosaic virus (DsMV) genome sequences; comparisons with DsMV continue to support VanMV as a vanilla infecting strain of DsMV. Phylogenetic analyses indicate that VanMV and DsMV share a common ancestor, with VanMV having the closest relationship with DsMV strains from the South Pacific.

Identification of VanN-type vancomycin resistance in an Enterococcus faecium isolate from chicken meat in Japan.

PubMed

Nomura, Takahiro; Tanimoto, Koichi; Shibayama, Keigo; Arakawa, Yoshichika; Fujimoto, Shuhei; Ike, Yasuyoshi; Tomita, Haruyoshi

2012-12-01

Five VanN-type vancomycin-resistant Enterococcus faecium strains were isolated from a sample of domestic chicken meat in Japan. All isolates showed low-level resistance to vancomycin (MIC, 12 mg/liter) and had the same pulsed-field gel electrophoresis profile. The vancomycin resistance was encoded on a large plasmid (160 kbp) and was expressed constitutively. The VanN-type resistance operon was identical to the first resistance operon to be reported, with the exception of a 1-bp deletion in vanT(N) and a 1-bp substitution in vanS(N).

Review of Gasteruption Latreille (Hymenoptera, Gasteruptiidae) from Iran and Turkey, with the description of 15 new species

PubMed Central

van Achterberg, Cornelis; Talebi, Ali Asghar

2014-01-01

Abstract The genus Gasteruption Latreille, 1796 (Hymenoptera: Evanioidea: Gasteruptiidae: Gasteruptiinae) from North Iran and Turkey is revised, keyed and fully illustrated for the first time. In total 36 species are treated of which 33 are recorded from Turkey and 23 from Iran. Fifteen species are new for science: Gasteruption aciculatum van Achterberg, sp. n., Gasteruption agrenum van Achterberg, sp. n., Gasteruption brevibasale van Achterberg & Saure, sp. n., Gasteruption coriacoxale van Achterberg, sp. n., Gasteruption flavimarginatum van Achterberg, sp. n., Gasteruption heminitidum van Achterberg, sp. n., Gasteruption henseni van Achterberg, sp. n., Gasteruption ischnolaimum van Achterberg, sp. n., Gasteruption nigrapiculatum van Achterberg, sp. n., Gasteruption paglianoi van Achterberg & Saure, sp. n., Gasteruption pseudolaticeps van Achterberg, sp. n., Gasteruption punctifrons van Achterberg, sp. n., Gasteruption schmideggeri van Achterberg & Saure, sp. n., Gasteruption scorteum van Achterberg, sp. n. and Gasteruption smitorum van Achterberg, sp. n. Twenty-one species are reported new for Turkey and 16 species new for Iran. Fifteen new synonyms are proposed: Foenus terrestris Tournier, 1877, Gasteruption trifossulatum Kieffer, 1904, and Gasteruption ignoratum Kieffer, 1912, of Gasteruption caucasicum (Guérin-Méneville, 1844); Gasteruption daisyi Alekseev, 1993, of Gasteruption dolichoderum Schletterer, 1889; Gasteruption assectator var. nitidulum Schletterer, 1885, of Gasteruption freyi (Tournier, 1877); Gasteruption schossmannae Madl, 1987, of Gasteruption hastator (Fabricius, 1804); Gasteryption fallaciosum Semenov, 1892, Gasteruption dubiosum Semenov, 1892 and Gasteruption obsoletum Semenov, 1892, of Gasteruption insidiosum Semenov, 1892; Gasteryption schewyrewi Semenov, 1892, of Gasteruption jaculator (Linnaeus, 1758); Gasteruption floreum Szépligeti, 1903, of Gasteruption lugubre Schletterer, 1889; Gasteruption trichotomma Kieffer, 1904, and Gasteruption palaestinum Pic, 1916, of Gasteruption merceti Kieffer, 1904; Gasteryption foveiceps Semenov, 1892, of Gasteruption nigrescens Schletterer, 1885, and Gasteruption libanense Pic, 1916, of Gasteruption syriacum Szépligeti, 1903. Gasteruption lugubre Schletterer, 1889, is recognised as a valid species. Lectotypes are designated for Ichneumon assectator Linnaeus, 1758; Ichneumon jaculator Linnaeus, 1758; Foenus terrestris Tournier, 1877; Foenus freyi Tournier, 1877; Foenus nigripes Tournier, 1877; Foenus goberti Tournier, 1877; Foenus granulithorax Tournier, 1877; Foenus minutus Tournier, 1877; Foenus borealis Thomson, 1883; Faenus diversipes Abeille de Perrin, 1879; Foenus rugulosus Abeille de Perrin, 1879; Faenus obliteratus Abeille de Perrin, 1879; Faenus undulatum Abeille de Perrin, 1879; Faenus variolosus Abeille de Perrin, 1879; Gasteruption distinguendum Schletterer, 1885; Gasteruption laeviceps Schletterer, 1885; Gasteruption thomsonii Schletterer, 1885; Gasteruption foveolatum Schletterer, 1889; Gasteruption sowae Schletterer, 1901; Gasteruption foveolum Szépligeti, 1903; Gasteruption floreum Szépligeti, 1903; Gasteruption caudatum Szépligeti, 1903; Gasteruption syriacum Szépligeti, 1903; Gasteruption merceti Kieffer, 1904 and Gasteruption ignoratum Kieffer, 1912. A neotype is designated for Gasteruption tournieri Schletterer, 1885. PMID:25561849

Laboratory and Field Spectroscopy of Moon analogue material

NASA Astrophysics Data System (ADS)

Offringa, Marloes; Foing, Bernard H.

2016-07-01

Samples derived from terrestrial analogue sites are studied to gain insight into lunar processes in their geological context (Foing, Stoker, Ehrenfreund, 2011). For this study samples from the volcanic region of the Eifel, Germany collected during our latest field campaigns in November 2015 and February 2016 (Foing et al., 2010), are analyzed with a variety of spectrometers. The aim is to obtain a database of analyzed samples that could be used as a reference for future in situ measurements. We also use a documented set of Moon-Mars relevant minerals curated at VU Amsterdam. We are using systematically for all samples UV-VIS and NIR reflectance spectrometers, and sporadically a Fourier Transform Infrared (FTIR) spectrometer, an X-Ray Fluorescence (XRF) spectrometer and a Raman laser spectrometer on control samples. Calibration of the UV-VIS and NIR reflectance spectrometers is the main focus of this research in order to obtain the clearest spectra. The calibration of the UV-VIS and NIR reflectance spectrometers requires the use of a good light source as well as suitable optical fibers to create a signal that covers the widest range in wavelengths available. To eliminate noise towards the edges of this range, multiple measurements are averaged and data is processed by dividing the signal by reference spectra. Obtained spectra can be tested for accuracy by comparing them with stationary laboratory spectrometers such as the FTIR spectrometer. The Raman, UV-VIS and NIR are also used in combination with the ExoGeoLab mock-up lander during field campaigns (Foing, Stoker, Ehrenfreund, 2011) also brought again to Eifel in February 2016, to prove the applicability of the equipment in the field. Acknowledgements: we thank Dominic Doyle for ESTEC optical lab support, Euan Monaghan (Leiden U) for FTIR measurement support, Wim van Westrenen for access to VU samples, Oscar Kamps (Utrecht U./ESTEC), Aidan Cowley (EAC) and Matthias Sperl (DLR) for support discussions

Revision of the family Chalcididae (Hymenoptera, Chalcidoidea) from Vietnam, with the description of 13 new species

PubMed Central

Narendran, T. C.; van Achterberg, Cornelis

2016-01-01

Abstract A total of 16 genera and 68 species of Chalcididae of Vietnam are taxonomically treated. Thirteen new species are described; the remaining 55 species are keyed, redescribed or provided with a diagnosis. Among these 37 species and eleven genera are recorded for the first time from Vietnam. The thirteen new species are: Antrocephalus neogalleriae Narendran & van Achterberg, sp. n.; Brachymeria neowiebesina Narendran & van Achterberg, sp. n., Brachymeria semirusula Narendran & van Achterberg, sp. n., Dirhinus neoclaviger Narendran & van Achterberg, sp. n., Epitranus narendrani van Achterberg, sp. n., Epitranus neonigriceps Narendran & van Achterberg, sp. n., Heydoniella vietnamensis Narendran & van Achterberg, sp. n., Megachalcis vietnamicus Narendran & van Achterberg, sp. n., Notaspidium vietnamicum Narendran & van Achterberg, sp. n., Oxycoryphe neotenax Narendran & van Achterberg, sp. n., Sthulapada neopadata Narendran & van Achterberg, sp. n., Sthulapada vietnamensis Narendran & van Achterberg, sp. n., and Tanycoryphus masii Narendran & van Achterberg, sp. n. The newly recorded genera are: Antrocephalus Kirby, 1883; Haltichella Spinola, 1811; Heydoniella Narendran, 2003; Hockeria Walker, 1834; Kriechbaumerella Dalla Torre, 1894; Notaspidium Dalla Torre, 1897; Oxycoryphe Kriechbaumer, 1894; Psilochalcis Kieffer, 1904; Sthulapada Narendran, 1989; Tanycorphus Cameron, 1905, and Trigonura Sichel, 1865. The following known species are recorded for the first time from Vietnam: Antrocephalus decipiens (Masi, 1929); Antrocephalus lugubris (Masi, 1932); Antrocephalus maculipennis (Cameron, 1905); Antrocephalus nasutus (Holmgren, 1869); Antrocephalus sepyra (Walker, 1846); Antrocephalus validicornis (Holmgren, 1868); Brachymeria alternipes (Walker, 1871); Brachymeria aurea (Girault, 1915); Brachymeria coxodentata Joseph, Narendran & Joy, 1972; Brachymeria euploeae (Westwood, 1837); Brachymeria hime Habu, 1960; Brachymeria jambolana Gahan, 1942; Brachymeria kamijoi Habu, 1960; Brachymeria lugubris (Walker, 1871); Brachymeria marmonti (Girault, 1924); Brachymeria minuta (Linnaeus, 1767); Brachymeria scutellocarinata Joseph, Narendran & Joy, 1972; Brachymeria shansiensis Habu, 1961; Brachymeria taiwana (Matsumura, 1910); Dirhinus anthracia Walker, 1846; Dirhinus claviger Bouček & Narendran, 1981; Epitranus albipennis Walker, 1874; Epitranus ater Bouček, 1982; Epitranus gauldi Bouček, 1982; Epitranus oxytelus Bouček, 1982; Epitranus ramnathi (Mani & Dubey, 1973); Haltichella delhensis Roy & Farooqi, 1984; Haltichella nipponensis Habu, 1960; Hockeria bangalorica Narendran, 1989; Hockeria guptai Narendran, 1989; Kriechbaumerella ayyari (Gahan, 1919); Kriechbaumerella cordigaster Roy & Farooqi, 1984; Kriechbaumerella destructor (Waterston, 1922); Kriechbaumerella nepalensis Narendran, 1989; Oxycoryphe scutellatus Narendran, 1989; Psilochalcis carinigena (Cameron, 1907), and Trigonura luzonensis Narendran, 1987. Brachymeria calopeplae Joseph, Narendran & Joy, 1972, is treated as a valid species. PMID:27110185

Investigating the Effect of van Hiele Phase-Based Instruction on Pre-Service Teachers' Geometric Thinking

ERIC Educational Resources Information Center

Armah, Robert Benjamin; Cofie, Primrose Otokonor; Okpoti, Christopher Adjei

2018-01-01

This study investigated the effect of van Hiele Phase-based Instruction (VHPI) on Ghanaian Pre-service Teachers' (PTs') geometric thinking in terms of the van Hiele Levels. A pre-test post-test quasi-experimental design was employed. There were 75 PTs each in the experimental group and the control group. Van Hiele Geometry Test (VHGT) was…

Experimental Testing of a Van De Graaff Generator as an Electromagnetic Pulse Generator

DTIC Science & Technology

2016-07-01

EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR THESIS...protection in the United States AFIT-ENP-MS-16-S-075 EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR...RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENP-MS-16-S-075 EXPERIMENTAL TESTING OF A VAN DE GRAAFF GENERATOR AS AN ELECTROMAGNETIC PULSE GENERATOR

78 FR 47817 - Parts and Accessories Necessary for Safe Operation; Application for an Exemption From Van Hool N...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

....V. and Coach USA AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of... exemption from Van Hool N.V. and Coach USA (Van Hool/Coach USA) to allow the use of double deck motorcoaches..., Van Hool/Coach USA is requesting an exemption that would allow the use of sleeper berths that comply...

Alternating current impedance spectroscopic analysis of biofunctionalized vertically-aligned silica nanospring surface for biosensor applications

NASA Astrophysics Data System (ADS)

Timalsina, Yukta P.

In this dissertation, a process of vertically-aligned (silica) nanosprings (VANS) based biosensor development is presented. Alternating current (AC) impedance spectroscopy has been used to analyze sensor response as a function of saline phosphate (SP) buffer and biological solutions. The sensor is a parallel plate capacitor consisting of two glass substrates coated with indium tin oxide (ITO), where the VANS [or randomly-aligned nanosprings (RANS)] grown on one substrate serve as the dielectric spacer layer. The response of a VANS device as a function of ionic concentration in SP buffer was examined and an equivalent circuit model was developed. The results demonstrated that VANS sensors exhibited greater sensitivity to the changes in SP concentration relative to the ITO sensors, which serve as controls. The biofunctionalized VANS surface via physisorption and the cross-linker method demonstrates the repeatability, specificity, and selectivity of the binding. The physisorption of biotinylated immunoglobulin G (B-IgG) onto the VANS surface simplifies the whole sensing procedure for the detection of glucose oxidase, since the avidin-conjugated glucose oxidase (Av-GOx) can directly be immobilized on the B-IgG. The cross linker method involves the covalent attachment of antibodies onto the functionalized VANS surface via imine bond. The experiments revealed that the VANS sensor response is solely the result of the interaction of target molecule i.e. mouse IgG with the probe layer, i.e. goat antimouse IgG (GalphaM IgG). It was determined that VANS-based sensors exhibit a greater magnitude of change between successive bio-layers relative to the controls above 100 Hz, which indicates that the addition of biomolecules inhibits the diffusion of ions and changes the effective dielectric response of the VANS via biomolecular polarization. The study of ionic transport in nanosprings suggested that conductance follows a scaling law. It was demonstrated that a VANS-based device exhibits a greater magnitude of change relative to the RANS device below 10 kHz, which has equivalent property of the ITO controls. This dissertation demonstrates the potential for VANS as a novel nanomaterial platform for the development of highly sensitive, selective, low cost, and label free biosensors.

Mathematical foundations of the dendritic growth models.

PubMed

Villacorta, José A; Castro, Jorge; Negredo, Pilar; Avendaño, Carlos

2007-11-01

At present two growth models describe successfully the distribution of size and topological complexity in populations of dendritic trees with considerable accuracy and simplicity, the BE model (Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997) and the S model (Van Pelt and Verwer in Bull. Math. Biol. 48:197-211, 1986). This paper discusses the mathematical basis of these models and analyzes quantitatively the relationship between the BE model and the S model assumed in the literature by developing a new explicit equation describing the BES model (a dendritic growth model integrating the features of both preceding models; Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997). In numerous studies it is implicitly presupposed that the S model is conditionally linked to the BE model (Granato and Van Pelt in Brain Res. Dev. Brain Res. 142:223-227, 2003; Uylings and Van Pelt in Network 13:397-414, 2002; Van Pelt, Dityatev and Uylings in J. Comp. Neurol. 387:325-340, 1997; Van Pelt and Schierwagen in Math. Biosci. 188:147-155, 2004; Van Pelt and Uylings in Network. 13:261-281, 2002; Van Pelt, Van Ooyen and Uylings in Modeling Dendritic Geometry and the Development of Nerve Connections, pp 179, 2000). In this paper we prove the non-exactness of this assumption, quantify involved errors and determine the conditions under which the BE and S models can be separately used instead of the BES model, which is more exact but considerably more difficult to apply. This study leads to a novel expression describing the BE model in an analytical closed form, much more efficient than the traditional iterative equation (Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997) in many neuronal classes. Finally we propose a new algorithm in order to obtain the values of the parameters of the BE model when this growth model is matched to experimental data, and discuss its advantages and improvements over the more commonly used procedures.

Evaluation of risk factors for vancomycin-induced nephrotoxicity.

PubMed

Park, So Jin; Lim, Na Ri; Park, Hyo Jung; Yang, Jae Wook; Kim, Min-Ji; Kim, Kyunga; In, Yong Won; Lee, Young Mee

2018-05-09

Background Vancomycin is a glycopeptide antibiotic of choice for the treatment of serious infections caused by multi-resistant Gram-positive bacteria. However, vancomycin-associated nephrotoxicity (VAN) often limits its use. Previous data suggested a few risk factors of VAN, including higher mean vancomycin trough level, higher daily doses, old age, long duration of vancomycin therapy, and concomitant nephrotoxins. Objective To evaluate the incidence and risk factors of VAN and determine whether higher vancomycin trough concentrations were associated with a greater risk for VAN. Settings A retrospective, observational, single-center study at the 1960-bed university-affiliated tertiary care hospital (Samsung Medical Center), Seoul, Korea. Method A retrospective analysis of adult patients who received vancomycin parenterally in a tertiary care medical center from March 1, 2013 to June 30, 2013 was performed. We excluded patients with a baseline serum creatinine level > 2 mg/dL and those who had a history of end-stage renal disease and dialysis at baseline. The clinical characteristics were compared between patients with nephrotoxicity and those without nephrotoxicity to identify the risk factors associated with VAN. Main outcome measure Incidence of VAN and VAN-associated risk factors were analyzed. Results Of the 315 vancomycin-treated patients, nephrotoxicity occurred in 15.2% of the patients. In multivariate analysis, higher vancomycin trough concentrations of > 20 mg∕L (OR 9.57, 95% CI 2.49-36.83, p < 0.01) and intensive care unit (ICU) residence (OR 2.86, 95% CI 1.41-5.82, p < 0.01) were independently associated with VAN. Conclusion Our findings suggest that higher vancomycin trough levels and ICU residence might be associated with a greater risk for VAN. More careful monitoring of vancomycin serum trough levels and patient status might facilitate the timely prevention of VAN.

Genetics Home Reference: dihydropyrimidine dehydrogenase deficiency

MedlinePlus

... NG, Bakker HD, Meinsma R, Van Lenthe H, De Abreu RA, Smeitink JA, Kayserili H, Apak MY, ... 9. Review. Citation on PubMed van Kuilenburg AB, De Abreu RA, van Gennip AH. Pharmacogenetic and clinical ...

Building Cultural Capability for Full-Spectrum Operations

DTIC Science & Technology

2008-01-01

Mol, Born, Willemsen, & Van der Molen , 2005; Caligiuri & Day, 2000). In addition to these broad traits, antecedents to cross-cultural competence...510-517. 18 Mol, S. T., Born, M. P., Willemsen, M. E., & Van Der Molen , H. T. (2005). Predicting expatriate job performance for selection purposes: A...et al., 2003). In addition, self-regulation has been shown to be critical for adjustment (Matsumoto et al., 2003; van Oudenhoven, Mol, & Van der Zee

Selective Perception for Robot Driving

DTIC Science & Technology

1992-05-01

models are theories of human cognitive activity during driving. Van der Molen and Botticher recently reviewed several of these models [ van der Molen 871...how to represent driving knowledge, how to perceive traffic situations, or how to process information to obtain actions. Van der Molen and Botticher...attempted to compare the operations of various models objectively on the same task [Rothengatter 88, van der Molen 87], but the models could be

Quality of Life for Adults with Asthma in a Military Setting

DTIC Science & Technology

1998-05-01

Tilley, Havstead, & Zoratti, 1997). More recently, van der Molen , et al. (1997) conducted a study comparing discriminative aspects of two generic...Symptom Management Faculty Group, UCSF. (1994). IMAGE: Journal of Nursing Scholarship, 26(4), 272-276. van der Molen , T., Postma, D., Schreuers, A...the most important (Earwood, 1996, Rutten- Van Molken, Van Doorslaer, & Rutten, 1992). Purpose of the Study When patients clarify their perceptions of

Rater Biases in Genetically Informative Research Designs: Comment on Bartels, Boomsma, Hudziak, van Beijsterveldt, and van den Oord (2007)

ERIC Educational Resources Information Center

Hoyt, William T.

2007-01-01

Rater biases are of interest to behavior genetic researchers, who often use ratings data as a basis for studying heritability. Inclusion of multiple raters for each sibling pair (M. Bartels, D. I. Boomsma, J. J. Hudziak, T. C. E. M. van Beijsterveldt, & E. J. C. G. van den Oord, 2007) is a promising strategy for controlling bias variance and may…

Application of Diffusion Monte Carlo to Materials Dominated by van der Waals Interactions

DOE PAGES

Benali, Anouar; Shulenburger, Luke; Romero, Nichols A.; ...

2014-06-12

Van der Waals forces are notoriously difficult to account for from first principles. We perform extensive calculation to assess the usefulness and validity of diffusion quantum Monte Carlo when applied to van der Waals forces. We present results for noble gas solids and clusters - archetypical van der Waals dominated assemblies, as well as a relevant pi-pi stacking supramolecular complex: DNA + intercalating anti-cancer drug Ellipticine.

[Mobile hospital -real time mobile telehealthcare system with ultrasound and CT van using high-speed satellite communication-].

PubMed

Takizawa, Masaomi; Miyashita, Toyohisa; Murase, Sumio; Kanda, Hirohito; Karaki, Yoshiaki; Yagi, Kazuo; Ohue, Toru

2003-01-01

A real-time telescreening system is developed to detect early diseases for rural area residents using two types of mobile vans with a portable satellite station. The system consists of a satellite communication system with 1.5Mbps of the JCSAT-1B satellite, a spiral CT van, an ultrasound imaging van with two video conference system, a DICOM server and a multicast communication unit. The video image and examination image data are transmitted from the van to hospitals and the university simultaneously. Physician in the hospital observes and interprets exam images from the van and watches the video images of the position of ultrasound transducer on screenee in the van. After the observation images, physician explains a results of the examination by the video conference system. Seventy lung CT screening and 203 ultrasound screening were done from March to June 2002. The trial of this real time screening suggested that rural residents are given better healthcare without visit to the hospital. And it will open the gateway to reduce the medical cost and medical divide between city area and rural area.

DdlN from Vancomycin-Producing Amycolatopsis orientalis C329.2 Is a VanA Homologue with d-Alanyl-d-Lactate Ligase Activity

PubMed Central

Marshall, C. Gary; Wright, Gerard D.

1998-01-01

Vancomycin-resistant enterococci acquire high-level resistance to glycopeptide antibiotics through the synthesis of peptidoglycan terminating in d-alanyl-d-lactate. A key enzyme in this process is a d-alanyl-d-alanine ligase homologue, VanA or VanB, which preferentially catalyzes the synthesis of the depsipeptide d-alanyl-d-lactate. We report the overexpression, purification, and enzymatic characterization of DdlN, a VanA and VanB homologue encoded by a gene of the vancomycin-producing organism Amycolatopsis orientalis C329.2. Evaluation of kinetic parameters for the synthesis of peptides and depsipeptides revealed a close relationship between VanA and DdlN in that depsipeptide formation was kinetically preferred at physiologic pH; however, the DdlN enzyme demonstrated a narrower substrate specificity and commensurately increased affinity for d-lactate in the C-terminal position over VanA. The results of these functional experiments also reinforce the results of previous studies that demonstrated that glycopeptide resistance enzymes from glycopeptide-producing bacteria are potential sources of resistance enzymes in clinically relevant bacteria. PMID:9791137

d-Ala-d-Ser VanN-Type Transferable Vancomycin Resistance in Enterococcus faecium▿

PubMed Central

Lebreton, François; Depardieu, Florence; Bourdon, Nancy; Fines-Guyon, Marguerite; Berger, Pierre; Camiade, Sabine; Leclercq, Roland; Courvalin, Patrice; Cattoir, Vincent

2011-01-01

Enterococcus faecium UCN71, isolated from a blood culture, was resistant to low levels of vancomycin (MIC, 16 μg/ml) but susceptible to teicoplanin (MIC, 0.5 μg/ml). No amplification was observed with primers specific for the previously described glycopeptide resistance ligase genes, but a PCR product corresponding to a gene called vanN was obtained using degenerate primers and was sequenced. The deduced VanN protein was related (65% identity) to the d-alanine:d-serine VanL ligase. The organization of the vanN gene cluster, determined using degenerate primers and by thermal asymmetric interlaced (TAIL)-PCR, was similar to that of the vanC operons. A single promoter upstream from the resistance operon was identified by rapid amplification of cDNA ends (RACE)-PCR. The presence of peptidoglycan precursors ending in d-serine and d,d-peptidase activities in the absence of vancomycin indicated constitutive expression of the resistance operon. VanN-type resistance was transferable by conjugation to E. faecium. This is the first report of transferable d-Ala-d-Ser-type resistance in E. faecium. PMID:21807981

Shifting Borders: A Case Study of Internationalisation of Education within a Dutch School Group in Amsterdam

ERIC Educational Resources Information Center

Prickarts, Boris

2017-01-01

This article focuses on a case study of internationalisation of education, a process of change pertaining to the mission, vision and delivery of education. Teachers working in international schools can be understood as gearing a student's disposition towards the ability and preparedness to handle and value differences and diversity. In an effort…

"I No Say You Say Is Boring": The Development of Pragmatic Competence in L2 Apology

ERIC Educational Resources Information Center

Chang, Yuh-Fang

2010-01-01

While the number of studies on pragmatic development has been increasing since Kasper and Schmidt's call for more research into this under-researched area (e.g., [Barron, A., 2003. Acquisition in Interlanguage Pragmatics: Learning How to do Things with Words in a Study Abroad Context. Benhamins, Amsterdam; Achiba, M., 2003. Learning to Request in…

Summer Conference on General Topology and Applications (10th) Held in Amsterdam on 15-18 August 1994

DTIC Science & Technology

1994-08-18

topology. Joint work by: I. Juhisz and Z. Szentmiid6ssy. Room: KC1.37 Time: TUE 16:40-1 7:00 ABSTRACTS 89 Forcing and Normality, II LUcia R. Junqueira...Gerard A. Venema (Calvin College, Grand Rapids, MI, USA) J. Vermeer (TU Delft, Delft, the Netherlands) Paolo Vitolo (Universita della Basilicata, Potenza

Potentials of Advanced Database Technology for Military Information Systems

DTIC Science & Technology

2001-04-01

UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP010866 TITLE: Potentials of Advanced Database Technology for Military... Technology for Military Information Systems Sunil Choennia Ben Bruggemanb a National Aerospace Laboratory, NLR, P.O. Box 90502, 1006 BM Amsterdam...application of advanced information tech- nology, including database technology , as underpin- actions X and Y as dangerous or not? ning is

Older Parents Providing Child Care for Adult Children: Does It Pay Off?

ERIC Educational Resources Information Center

Geurts, Teun; Poortman, Anne-Rigt; van Tilburg, Theo G.

2012-01-01

This study examined whether past grandparental child care is related to present support from adult children. On the basis of social exchange theory, the authors expected that grandparental child care creates a debt that is repaid in the form of receiving support later in life. Using data from the Longitudinal Aging Study Amsterdam (N = 349…

An Experimental Evaluation of the Effect of Hole Fabrication/Treatment Techniques on Residual Strength and Fatigue Life of Polycarbonate Specimens with Holes

DTIC Science & Technology

1993-08-01

34The Effect of Dimpling on the Fatigue Strength of Loaded Holes in a Corrosive Environment," Experimental Techniques, Vol. 9, September 1985, 33-36. 34...Expansion on the Fatigue Behavior of 7079-T652 Alluminium [sic] Alloy," NLR TR 74016 U, National Aerospace Laboratory (NLR), Amsterdam, The

Book Reading, Borrowing and Buying Habits (Eighteenth Congress, Amsterdam, the Netherlands, June 9-15 1968). Report.

ERIC Educational Resources Information Center

Brink, R. E. M. van den

Investigation into the book buying, reading and borrowing habits is in many countries still in its infancy. Furthermore it is not yet possible to link up scientifically the socio-economic factors and market behavior. However it is justifiable to take the following principles: (1) the standard of economic development of a country determines the…

Mobile Game-Based Learning in Secondary Education: Engagement, Motivation and Learning in a Mobile City Game

ERIC Educational Resources Information Center

Huizenga, J.; Admiraal, W.; Akkerman, S.; Dam, G. ten

2009-01-01

Using mobile games in education combines situated and active learning with fun in a potentially excellent manner. The effects of a mobile city game called Frequency 1550, which was developed by The Waag Society to help pupils in their first year of secondary education playfully acquire historical knowledge of medieval Amsterdam, were investigated…

Visual Culture Learning Communities: How and What Students Come to Know in Informal Art Groups

ERIC Educational Resources Information Center

Freedman, Kerry; Heijnen, Emiel; Kallio-Tavin, Mira; Karpati, Andrea; Papp, Laszlo

2013-01-01

This article is the report of a large-scale, international research project involving focus group interviews of adolescent and young adult members of a variety of self-initiated visual culture groups in five urban areas (Amsterdam, Budapest, Chicago, Helsinki, and Hong Kong). Each group was established by young people around their interests in the…

Changes in sexual behaviour and the fall in incidence of HIV infection among homosexual men.

PubMed Central

van Griensven, G. J.; de Vroome, E. M.; Goudsmit, J.; Coutinho, R. A.

1989-01-01

To investigate the epidemiology and normal course of infection with HIV the prevalence and incidence of the infection were studied among two cohorts of homosexual men in Amsterdam in 1980-7. The cumulative incidence of infection increased from a weighted 2.2% in 1980 to 39.0% in 1987. The estimated yearly incidence of HIV was 3.0% in 1981, rose to 8.8% in 1984, and fell gradually to 0% in 1987. During the study the sexual behaviour of the cohorts was examined. The number of men with whom anopenetrative intercourse was practised fell from a mean of 10.6 to 1.4 for those positive for HIV antibody, whereas the number with whom anoreceptive intercourse was practised fell from a mean of 3.7 to 0.5 for those negative for the antibody. In addition, there was a reduction in the number of cases of hepatitis B and syphilis among men in general. The decline in infection with HIV was assumed to be linked to changes in sexual behaviour. Such changes practised early in the course of the epidemic probably had a strong effect on the number of cases of AIDS among homosexual men in Amsterdam. PMID:2493866

Usage of an online healthy lifestyle program by pregnant women attending midwifery practices in Amsterdam.

PubMed

van Zutphen, Moniek; Milder, Ivon E; Bemelmans, Wanda J

2008-06-01

To determine reach, attrition and program engagement and their associations with user characteristics for an online healthy lifestyle program for pregnant women. From March to August 2006, 1382 pregnant women visiting 20 midwifery practices in Amsterdam were invited to enroll in a healthy lifestyle program through registration on the program website (at home). User characteristics were self-reported upon enrollment, while program use was objectively monitored until January 2007. Seventeen percent (n=238) of the women who received information from their midwife enrolled. Most women were highly educated (68%) and already had a healthy lifestyle. About half of them (52%) continued to use the program throughout their pregnancy. Less lower than higher educated women continued using the program (45% vs. 63%, p=0.02). When e-mails were opened almost all lifestyle topics were accessed (85%), but links to related websites were used less often (12%). The healthy lifestyle program did not reach a substantial proportion of the target population. Only 9% of those invited continued to use the program throughout their pregnancies. In addition to that there was selective enrollment and selective attrition. This research confirms that disadvantaged women, who need the intervention most, are least easily reached.

The first Team Haemophilia Education meeting, 2015, Amsterdam, The Netherlands.

PubMed

Berntorp, Erik; Hart, Daniel; Mancuso, Maria Elisa; d'Oiron, Roseline; Perry, David; O'Mahony, Brian; Kaczmarek, Radoslaw; Crato, Miguel; Pasi, John; Miners, Alec; Carlsson, Katarina Steen; Kitchen, Steve; Boehlen, Françoise; Giangrande, Paul; Cebura, Elizabete; Uitslager, Nanda; Osooli, Mehdi; Janeckova, Daniela; Haldon, Rosie; Rivolta, Gianna Franca

2016-07-01

Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7-8 May 2015 in Amsterdam, The Netherlands, aimed to promote the optimal care of haemophilia patients through education of the multidisciplinary treatment team. This was achieved by reviewing the latest developments in haemophilia management, considering how these can be implemented in the clinic to improve patient care and providing a platform for networking and debate for all haemophilia treatment team members. Haemophilia treatment centres from several countries were asked to complete a premeeting online questionnaire to establish the biggest challenges that they face when managing patients. The concerns expressed were used to develop the agenda, which comprised a combination of formal presentations, case studies and informal workshops covering such topics as pharmacokinetics, laboratory assays and tailoring of treatment to individual patients. This report is a summary of the key developments in haemophilia care presented by various investigators and healthcare professionals at THE meeting 2015. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Stakeholders' Perception on National Heatwave Plans and Their Local Implementation in Belgium and The Netherlands.

PubMed

van Loenhout, Joris Adriaan Frank; Rodriguez-Llanes, Jose Manuel; Guha-Sapir, Debarati

2016-11-10

National heatwave plans are aimed at reducing the avoidable human health consequences due to heatwaves, by providing warnings as well as improving communication between relevant stakeholders. The objective of this study was to assess the perceptions of key stakeholders within plans in Belgium and The Netherlands on their responsibilities, the partnerships, and the effectiveness of the local implementation in Brussels and Amsterdam. Key informant interviews were held with stakeholders that had an important role in development of the heatwave plan in these countries, or its implementation in Brussels or Amsterdam. Care organisations, including hospitals and elderly care organisations, had a lack of familiarity with the national heatwave plan in both cities, and prioritised heat the lowest. Some groups of individuals, specifically socially isolated individuals, are not sufficiently addressed by the current national heatwave plans and most local plans. Stakeholders reported that responsibilities were not clearly described and that the national plan does not describe tasks on a local level. We recommend to urgently increase awareness on the impact of heat on health among care organisations. More emphasis needs to be given to the variety of heat-risk groups. Stakeholders should be involved in the development of updates of the plans.

Resonance oscillations of nonreciprocal long-range van der Waals forces between atoms in electromagnetic fields

NASA Astrophysics Data System (ADS)

Sherkunov, Yury

2018-03-01

We study theoretically the van der Waals interaction between two atoms out of equilibrium with an isotropic electromagnetic field. We demonstrate that at large interatomic separations, the van der Waals forces are resonant, spatially oscillating, and nonreciprocal due to resonance absorption and emission of virtual photons. We suggest that the van der Waals forces can be controlled and manipulated by tuning the spectrum of artificially created random light.

Storings analyse Ten Behoeve van het Materieelverzorgingsplan (Failure Analysis for the Maintenance Plan)

DTIC Science & Technology

1990-05-01

oporachtnemer verwezen naar de ’Algemone Voorwaarden voor Onderzoeks- opdrachten TNO’. dan wet de betreflende terzake fijasen partlijen gesloten * 11 ...ixvulling van het onderhoudsschema 9 2.4 Invulling van het onderhoudsschema in de praktijk 14 2.5 Gonclusies 16 3 STORINGSANALYSES 18 3.1 ’Failure mode...nnfd- en subgroep (dit is een opdeling van bet systeem naar functioneel sanienhangende delen). Pa gina 9 - Het onderhoudsniveau waar jedere

Implication of Two-Coupled Differential Van der Pol Duffing Oscillator in Weak Signal Detection

NASA Astrophysics Data System (ADS)

Peng, Hang-hang; Xu, Xue-mei; Yang, Bing-chu; Yin, Lin-zi

2016-04-01

The principle of the Van der Pol Duffing oscillator for state transition and for determining critical value is described, which has been studied to indicate that the application of the Van der Pol Duffing oscillator in weak signal detection is feasible. On the basis of this principle, an improved two-coupled differential Van der Pol Duffing oscillator is proposed which can identify signals under any frequency and ameliorate signal-to-noise ratio (SNR). The analytical methods of the proposed model and the construction of the proposed oscillator are introduced in detail. Numerical experiments on the properties of the proposed oscillator compared with those of the Van der Pol Duffing oscillator are carried out. Our numerical simulations have confirmed the analytical treatment. The results demonstrate that this novel oscillator has better detection performance than the Van der Pol Duffing oscillator.

van Manen's method and reduction in a phenomenological hermeneutic study.

PubMed

Heinonen, Kristiina

2015-03-01

To describe van Manen's method and concept of reduction in a study that used a phenomenological hermeneutic approach. Nurse researchers have used van Manen's method in different ways. Participants' lifeworlds are described in depth, but descriptions of reduction have been brief. The literature and knowledge review and manual search of research articles. Databases Web Science, PubMed, CINAHL and PsycINFO, without applying a time period, to identify uses of van Manen's method. This paper shows how van Manen's method has been used in nursing research and gives some examples of van Manen's reduction. Reduction enables us to conduct in-depth phenomenological hermeneutic research and understand people's lifeworlds. As there are many variations in adapting reduction, it is complex and confusing. This paper contributes to the discussion of phenomenology, hermeneutic study and reduction. It opens up reduction as a method for researchers to exploit.

Scaling laws for van der Waals interactions in nanostructured materials.

PubMed

Gobre, Vivekanand V; Tkatchenko, Alexandre

2013-01-01

Van der Waals interactions have a fundamental role in biology, physics and chemistry, in particular in the self-assembly and the ensuing function of nanostructured materials. Here we utilize an efficient microscopic method to demonstrate that van der Waals interactions in nanomaterials act at distances greater than typically assumed, and can be characterized by different scaling laws depending on the dimensionality and size of the system. Specifically, we study the behaviour of van der Waals interactions in single-layer and multilayer graphene, fullerenes of varying size, single-wall carbon nanotubes and graphene nanoribbons. As a function of nanostructure size, the van der Waals coefficients follow unusual trends for all of the considered systems, and deviate significantly from the conventionally employed pairwise-additive picture. We propose that the peculiar van der Waals interactions in nanostructured materials could be exploited to control their self-assembly.

Research Update: Fast and tunable nanoionics in vertically aligned nanostructured films

NASA Astrophysics Data System (ADS)

Lee, Shinbuhm; MacManus-Driscoll, Judith L.

2017-04-01

This review provides the design principles to develop new nanoionic applications using vertically aligned nanostructured (VAN) thin films, incorporating two phases which self-assemble in one film. Tunable nanoionics has attracted great attention for energy and device applications, such as ion batteries, solid oxide fuel cells, catalysts, memories, and neuromorphic devices. Among many proposed device architectures, VAN films have strong potential for nanoionic applications since they show enhanced ionic conductivity and tunability. Here, we will review the recent progress on state-of-the-art nanoionic applications, which have been realized by using VAN films. In many VAN systems made by the inclusion of an oxygen ionic insulator, it is found that ions flow through the vertical heterointerfaces. The observation is consistent with structural incompatibility at the vertical heteroepitaxial interfaces resulting in oxygen deficiency in one of the phases and hence to oxygen ion conducting pathways. In other VAN systems where one of the phases is an ionic conductor, ions flow much faster within the ionic conducting phase than within the corresponding plain film. The improved ionic conduction coincides with much improved crystallinity in the ionically conducting nanocolumnar phase, induced by use of the VAN structure. Furthermore, for both cases Joule heating effects induced by localized ionic current flow also play a role for enhanced ionic conductivity. Nanocolumn stoichiometry and strain are other important parameters for tuning ionic conductivity in VAN films. Finally, double-layered VAN film architectures are discussed from the perspective of stabilizing VAN structures which would be less stable and hence less perfect when grown on standard substrates.

Martin Van Buren National Historic Site transportation analysis report

DOT National Transportation Integrated Search

2010-10-01

The Volpe Transportation Systems Center (Volpe Center) is providing transportation support to Martin Van Buren National Historic Site's (NHS) first General Management Plan (GMP), which will be complete in 2010 or 2011. Currently, Martin Van Buren NHS...

The Dramatic Methods of Hans van Dam.

ERIC Educational Resources Information Center

van de Water, Manon

1994-01-01

Interprets for the American reader the untranslated dramatic methods of Hans van Dam, a leading drama theorist in the Netherlands. Discusses the functions of drama as a method, closed dramatic methods, open dramatic methods, and applying van Dam's methods. (SR)

78 FR 37270 - Qualification of Drivers; Exemption Applications; Vision

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... (IA) Thomas M. Harris (MI) Paul M. Hinkson (TN) Ellie L. Murphree (AL) Michael P. Passmore (FL) Wendell S. Sehen (OH) Gary E. Valentine (OH) Kevin W. Van Arsdol (CO) Charles Van Dyke (WI) Harlon C. Van...

Toward an Operational Definition of Cross-Cultural Competence from the Literature

DTIC Science & Technology

2008-01-01

Journal of Applied Psychology, 73, 410-420. Mol, S. T., Born, M. P., Willemsen, M. E., & Van Der Molen , H. T. (2005). Predicting expatriate job...decision-making processes (Ang, Van Dyne, Koh, & Ng, 2004; Ang, Van Dyne, & Koh, 2007). Because the CQ has demonstrated validity and covers the...empirical foundation. U.S. Army Research Institute for the Behavioral and Social Sciences, Study Report 2008-1. Arlington, VA: ARI. Ang, S., Van Dyne, L

A Design Procedure for Minimizing Propeller-Induced Vibration in Hull Structural Elements.

DTIC Science & Technology

1979-09-01

Propeller," 12th International Towing Tank Conference, Rome, 1969. 46. Van Manen , J. D., "The Effect of Cavitation on the Interaction Be- tween Propeller...The wake, when determined in absence of the propeller, is called the nominal wake field. Van Oossanen [8) points out that it is becoming...wire anemometer and the laser-Doppler anomometer. These are discussed briefly in a paper by van Gent and van Oossanen [11. 4. Estimate Longitudinal

Who Do We Deploy for Psychological Operations: A Function Profile for TPT Members

DTIC Science & Technology

2008-01-01

doet onderzoek om de ontwikkeling v’an PSYOPS in Nederland te ondersteunen. Een eerste stap, in het goed voorbereiden en uitvoeren van PSYOPS is het...bezit. De focus van het huidige project ligt op de selectiemethode van mensen die PSYOPS functies gaan vervullen. Naast Nederland zijn er ook andere NAVO...deze interviews kwam naar voren dat verschillende landen kampen met dezelfde problemen als Nederland wat betreft de selectie van het PSYOPS personeel

Beslisbevoegdheden van de Uitgestegen Soldaat. Deel B: Verbetering van Situational Awareness Met Behulp van de Soldier Digital Assistant in een Gesimuleerde Omgeving (Authority and Responsbility of the Dismounted Soldier. Part B. Improving the Situational Awareness using the Soldier Digital Assistant in a Simulated Environment)

DTIC Science & Technology

2007-04-01

Dergelijke omngevingen zijn tot op heden vrijwel uitsluitend gebruikt voor training en onderwijs , maar slechts zeer sporadisch voor wetenschappelijk...Onderstaande instanties/personen ontvangen een volledig exemplaar van het rapport. 1 DMO/SC-DR&D standaard inclusief digitale versie bijgeleverd op cd

Militaire Toepassingen Van Adaptieve Optiek (Military Applications of Adaptive Optics)

DTIC Science & Technology

2006-09-01

dat op dit moment met de beschikbare theorie mogelijk is. Een ander interessant aspect is de mate waarin de turbulentie effecten het jam patroon...systemen In WEAG studie JP8. 11 is aangetoond dat in theorie adaptieve technieken een verbetering van de prestaties van een DIRCM systeem kunnen...Molenaar; Theorie van de laserscintillometer; TNO repot PHL 1978-16 (1978). TNO-rapport I TNO-DV 2006 A336 35/35 6 Ondertekening Den Haag, september 2006

Kwalificate/Classificatie van Explosieve Stoffen en Munitie. Rapport 2. Testontwikkeling (Qualification/Classification Explosive Materials and Munition. 2. Test Development)

DTIC Science & Technology

1992-11-01

beschermkap van het apparaat af te halen , waardoor bij een eventuele ontsteking het energetisch materiaal (al dan niet brandend) weg kan springen. Tevens...TNO-DefensieonderzoekPr TN TNO-rapport Kwalificatielclassificatie van explosieve stoffen ~ PML 1992-68 en munitief Rapport ]I: Testontwikkeling...rapport Kwalificatielclassificatie van explosieve stoffen PML 1992-68 en munitie Rapport f1: Testontwikkeling november 1992 ~~- ExorrIaar no:- 1ýMI

P15.04DEVELOPMENT OF A NEW QUESTIONNAIRE TO MEASURE INSTRUMENTAL ACTIVITIES OF DAILY LIVING (I-ADL) IN PATIENTS WITH PRIMARY BRAIN TUMOURS: RESULTS OF PHASE 1

PubMed Central

Dirven, L.; Meijer, W.; Sikkes, S.A.M.; Reijneveld, J.C.; Aaronson, N.K.; Uitdehaag, B.M.J.; Taphoorn, M. J. B.

2014-01-01

BACKGROUND: Next to health-related quality of life, information on daily life functioning in brain tumour patients is essential. Instrumental Activities of Daily Living (I-ADL) are complex daily activities, such as food preparation and shopping. I-ADL may be negatively influenced by a cognitive decline, characteristic of brain tumor patients. OBJECTIVE: In the first phase of this project, we generated a provisional list of items measuring I-ADL that are relevant for primary brain tumour patients. METHODS: Questions from the Amsterdam IADL Questionnaire®, a 70-item questionnaire developed and validated to measure I-ADL in patients with dementia, were evaluated for relevance to brain tumour patients. In addition, new activities were generated. In the first step, 6 professional experts in neuro-oncology and 10 primary brain tumour patient-proxy dyads were asked to evaluate items in the Amsterdam IADL Questionnaire®. Experts had to indicate if these activities (1) could be considered as I-ADL, (2) were affected in brain tumour patients and (3) were clearly formulated. Patients and their proxies only needed to answer the latter two questions. In the second step, the same 6 experts, and in addition 6 other patient-proxy dyads were asked to generate new activities. To do so, in-depth interviews were conducted. Decision rules were determined to aid in deciding which items to retain (step 1) or to add (step 2). Activities that were indicated as IADL, affected and clearly formulated were retained. Activities that were considered as IADL and affected, but not clearly formulated, were rephrased. New activities that were frequently generated were added to the existing list of items. RESULTS: In step 1, experts indicated that 37% of the activities described in the Amsterdam IADL questionnaire® fulfilled all three criteria: conform the definition of IADL, clearly formulated and affected in brain tumour patients. Twenty-three per cent of the activities were affected and conform the provided definition, but not clearly formulated. According to patients and their proxies, 19% and 17% of the activities were clearly formulated and affected in brain tumour patients, respectively. Moreover, 1-3% of the activities were indicated to be affected, but not clearly formulated. Several new activities (concerning social interaction and work) were generated in step 2. With the decision rules as guide, it was decided in consensus that a total of 30 questions of the Amsterdam IADL questionnaire® could also be used to measure I-ADL in primary brain tumour patients. In addition, 16 new questions covering other relevant activities for brain tumour patients were added. CONCLUSION: This first phase resulted in a provisional questionnaire of 46 items intending to measure I-ADL in primary brain tumour patients. The next step is to validate this provisional questionnaire in a larger sample of patients.

Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174.

PubMed

Arias, C A; Weisner, J; Blackburn, J M; Reynolds, P E

2000-07-01

Vancomycin resistance in Enterococcus gallinarum results from the production of UDP-MurNAc-pentapeptide[D-Ser]. VanT, a membrane-bound serine racemase, is one of three proteins essential for this resistance. To investigate the selectivity of racemization of L-Ser or L-Ala by VanT, a strain of Escherichia coli TKL-10 that requires D-Ala for growth at 42 degrees C was used as host for transformation experiments using plasmids containing the full-length vanT from Ent. gallinarum or the alanine racemase gene (alr) of Bacillus stearothermophilus: both plasmids were able to complement E. coli TKL-10 at 42 degrees C. No alanine or serine racemase activities were detected in the host strain E. coli TKL-10 grown at 30, 34 or 37 degrees C. Serine and alanine racemase activities were found almost exclusively (96%) in the membrane fraction of E. coli TKL-10/pCA4(vanT): the alanine racemase activity of VanT was 14% of the serine racemase activity in both E. coli TKL-10/pCA4(vanT) and E. coli XL-1 Blue/pCA4(vanT). Alanine racemase activity was present mainly (95%) in the cytoplasmic fraction of E. coli TKL-10/pJW40(alr), with a trace (1.6%) of serine racemase activity. Additionally, DNA encoding the soluble domain of VanT was cloned and expressed in E. coli M15 as a His-tagged polypeptide and purified: this polypeptide also exhibited both serine and alanine racemase activities; the latter was approximately 18% of the serine racemase activity, similar to that of the full-length, membrane-bound enzyme. N-terminal sequencing of the purified His-tagged polypeptide revealed a single amino acid sequence, indicating that the formation of heterodimers between subunits of His-tagged C-VanT and endogenous alanine racemases from E. coli was unlikely. The authors conclude that the membrane-bound serine racemase VanT also has alanine racemase activity but is able to racemize serine more efficiently than alanine, and that the cytoplasmic domain is responsible for the racemase activity.

Acute kidney injury associated with concomitant vancomycin and piperacillin/tazobactam administration: a systematic review and meta-analysis.

PubMed

Chen, Xiao-Yu; Xu, Ri-Xiang; Zhou, Xin; Liu, Yang; Hu, Cheng-Yang; Xie, Xue-Feng

2018-05-11

As a tricyclic glycopeptide antibiotic used to treat acute infections, Vancomycin (VAN) is often administered with piperacillin/tazobactam (PT) to treat various infections in clinical practice. However, whether the combination of these two drugs, compared to VAN alone, can cause an increased risk of acute kidney injury (AKI) remains controversial. This study aims to identify the correlation between the development of AKI and the combined use of VAN and PT. We conducted a meta-analysis of eight observational cohort studies (a total of 10727 participants received VAN and PT versus VAN and other β-lactams). PubMed, Chinese Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI) Database, Wan Fang Digital Periodicals Database (WFDP), and China Science Citation Database (CSCD) were searched through April 2017 using "vancomycin" and "piperacillin" and "tazobactam" as well as "acute kidney injury" or "acute renal failure" or "AKI" or "ARF" or "nephrotoxicity." Two reviewers extracted the data and assessed the risk of bias. A correlation was found between the development of AKI and concurrent use of VAN and PT compared with concomitant VAN and β-lactams (OR 1.57; 95% CI, 1.13-2.01; I 2  = 76.4%, p < 0.001). Similar findings were obtained in an analysis of studies comparing concurrent VAN and PT use with concurrent VAN and β-lactam (cefepime) use (OR 1.50; 95% CI, 1.07-1.93; I 2  = 80.5%, p < 0.001). Exclusion of fair-quality and low-quality articles did not change the results (OR 1.49; 95% CI, 1.06-1.92; I 2  = 84.1%, p < 0.001). Regarding β-lactam therapy in clinical practice, an elevated risk of AKI due to the combined use of VAN and PT should be considered.

Characterization and modelling of VanT: a novel, membrane-bound, serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174.

PubMed

Arias, C A; Martín-Martinez, M; Blundell, T L; Arthur, M; Courvalin, P; Reynolds, P E

1999-03-01

Sequence determination of a region downstream from the vanXYc gene in Enterococcus gallinarum BM4174 revealed an open reading frame, designated vanT, that encodes a 698-amino-acid polypeptide with an amino-terminal domain containing 10 predicted transmembrane segments. The protein contained a highly conserved pyridoxal phosphate attachment site in the C-terminal domain, typical of alanine racemases. The protein was overexpressed in Escherichia coli, and serine racemase activity was detected in the membrane but not in the cytoplasmic fraction after centrifugation of sonicated cells, whereas alanine racemase activity was located almost exclusively in the cytoplasm. When the protein was overexpressed as a polypeptide lacking the predicted transmembrane domain, serine racemase activity was detected in the cytoplasm. The serine racemase activity was partially (64%) inhibited by D-cycloserine, whereas host alanine racemase activity was almost totally inhibited (97%). Serine racemase activity was also detected in membrane preparations of constitutively vancomycin-resistant E. gallinarum BM4174 but not in BM4175, in which insertional inactivation of the vanC-1 D-Ala:D-Ser ligase gene probably had a polar effect on expression of the vanXYc and vanT genes. Comparative modelling of the deduced C-terminal domain was based on the alignment of VanT with the Air alanine racemase from Bacillus stearothermophilus. The model revealed that almost all critical amino acids in the active site of Air were conserved in VanT, indicating that the C-terminal domain of VanT is likely to adopt a three-dimensional structure similar to that of Air and that the protein could exist as a dimer. These results indicate that the source of D-serine for peptidoglycan synthesis in vancomycin-resistant enterococci expressing the VanC phenotype involves racemization of L- to D-serine by a membrane-bound serine racemase.

Space Van system update

NASA Astrophysics Data System (ADS)

Cormier, Len

1992-07-01

The Space Van is a proposed commercial launch vehicle that is designed to carry 1150 kg to a space-station orbit for a price of $1,900,000 per flight in 1992 dollars. This price includes return on preoperational investment. Recurring costs are expected to be about $840,000 per flight. The Space Van is a fully reusable, assisted-single-stage-to orbit system. The most innovative new feature of the Space Van system is the assist-stage concept. The assist stage uses only airbreathing engines for vertical takeoff and vertical landing in the horizontal attitude and for launching the rocket-powered orbiter stage at mach 0.8 and an altitude of about 12 km. The primary version of the orbiter is designed for cargo-only without a crew. However, a passenger version of the Space Van should be able to carry a crew of two plus six passengers to a space-station orbit. Since the Space Van is nearly single-stage, performance to polar orbit drops off significantly. The cargo version should be capable of carrying 350 kg to a 400-km polar orbit. In the passenger version, the Space Van should be able to carry two crew members - or one crew member plus a passenger.

Critical lines for an unequal size of molecules in a binary gas-liquid mixture around the van Laar point using the combination of the Tompa model and the van der Waals equation.

PubMed

Gençaslan, Mustafa; Keskin, Mustafa

2012-02-14

We combine the modified Tompa model with the van der Waals equation to study critical lines for an unequal size of molecules in a binary gas-liquid mixture around the van Laar point. The van Laar point is coined by Meijer and it is the only point at which the mathematical double point curve is stable. It is the intersection of the tricritical point and the double critical end point. We calculate the critical lines as a function of χ(1) and χ(2), the density of type I molecules and the density of type II molecules for various values of the system parameters; hence the global phase diagrams are presented and discussed in the density-density plane. We also investigate the connectivity of critical lines at the van Laar point and its vicinity and discuss these connections according to the Scott and van Konynenburg classifications. It is also found that the critical lines and phase behavior are extremely sensitive to small modifications in the system parameters. © 2012 American Institute of Physics

Nanotechnology-Enabled Optical Molecular Imaging of Breast Cancer

DTIC Science & Technology

2013-09-01

Jacobus J M van Der Hoeven, Elsken van Der Wall, Petra van Der Groep, Paul J van Diest, Emile F I Comans, Urvi Joshi, et al. 2002. “Biologic...Leigh G Seamon, William B Farrar, and Edward W Martin . 2008. “Novel perioperative imaging with 18F-FDG PET/CT and intraoperative 18F-FDG detection...www.springerlink.com/content/n752170246r84660/. Hall, Nathan C, Stephen P Povoski, Douglas A Murrey, Michael V Knopp, and Edward W Martin . 2007. “Combined

Submaximal Exercise Testing Treadmill and Floor Walking.

DTIC Science & Technology

1978-05-01

Amputations," Archives of Physical Medicine and Rehabilitation, 56:67-71, 1975. 36. van der Walt, W. H., and Wyndham, C. H,, "An Equation for...C. H., van Renaburg, A. J., Rogr, G. G., Greyson, J. S.. and van der Walt, V. H., "Walk or Jog for Health: I, The Energy Cost of Walking or Running at...G., Greyson, J. S., and van der Walt, V. H., "Walk or Jog for Health: II, Iatimating the Maximi Aerobic Capacity for Exercise,* South &frIca Kedical

A Representational Approach to Knowledge and Multiple Skill Levels for Broad Classes of Computer Generated Forces

DTIC Science & Technology

1997-12-01

that I’ll turn my attention to that computer game we’ve talked so much about... Dave Van Veldhuizen and Scott Brown (soon-to-be Drs. Van Veldhuizen and...Industry Training Systems Conference. 1988. 37. Van Veldhuizen , D. A. and L. J Hutson. "A Design Methodology for Domain Inde- pendent Computer...proposed by Van Veld- huizen and Hutson (37), extends the general architecture to support both a domain- independent approach to implementing CGFs and

REMOTE LAND MINE(FIELD) DETECTION. An Overview of Techniques (DETECTIE VAN LANDMIJNEN EN MIJNENVELDEN OP AFSTAND. Een Overzicht van de technieken),

DTIC Science & Technology

1994-09-01

titel DETECTIE VAN LANDMIJNEN EN MIJNENVELDEN OP AFSTAND, een overzicht van de technieken auteur (s) Drs. J.S. Groot, Ir. Y.H.L. Janssen datum september...functions based on set theory . The fundamental theory is developed in the sixties. This theory was applicable to binary images (black-and-white images...held at TNO-FEL. Various subjects related to fusion techniques: Dempster Shafer theory , Bayesian inference, Kalman filtering, fuzzy logic. [A15], [B4

Beta-catenin: A Potential Survival Marker of Breast Cancer Stem Cells

DTIC Science & Technology

2006-09-01

T. C., Alexander, C. M., Georges-Labouesse, E., Van der Neut , R., Kreidberg, J. A., Jones, C. J., Sonnenberg, A. and Streuli, C. H. (2001...de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A. P., Tjon-Pon-Fong, M., Moerer, P., van den Born, M...Scherer, D. C., Willert, K., Hintz, L., Nusse, R. & Weissman, I. L. (2003) Nature 423, 409-14. 36. van de Wetering, M., Sancho, E., Verweij, C

DoD Electronic Data Interchange (EDI) Convention: ASC X12 Transaction Set 836 Contract Award (Version 003010)

DTIC Science & Technology

1993-01-01

upon designation of DoD Activity Address Code (DoDAAC) or other code coordinated with the value-added network (VAN). Mandatory ISA06 106 Interc.ange...coordinated with the value-added network (VAN). Non-DoD activities use identification code qualified by ISA05 and coordinated with the VAN. Mandatory...designation of DoD Activity Address Code (DoDAAC) or other code coordinated with the value-added network (VAN). Mandatory ISA08 107 Interchange Receiver

Definitie Rapport Taktisch LAN Demonstratie (Definition Report Tactical LAN Demonstration)

DTIC Science & Technology

1990-06-01

am deze sneiheid te halen . Hierover kan eon uitspraak warden gedaan, enerzijds na de ontwikkeling van het S-4 interface en anderzijds na berokeningen...90-A02 *2ma~D. Definitie rapport taktisch LAN Niels Ult deze urgave reai erorden verrnengvldigd er of openbaar genakt door MiddeI van druk. folokopre...microfrilm Of OP wetke arroere 00lze 000 00k. zonoe, O~u S vdorafgaanoe loestermeng van TNOHet ter inzage gen van het TNO-rapport Ing. R. J . C.14

Testbed Environment for Distributed Observation (testbed omgeving voor gedistribueerde waarneming)

DTIC Science & Technology

2006-05-01

het IP-adres en portnumnmer van de MID halen . Ook de naamn van de XML-file om de NID te beschrijven staat hierin vermeld (in dit geval ’CSD.xmId’) in...DeviceML beschrijving van de NID op te halen . Dit wordt gedaan door een TCP/IP verbinding op te zetten tussen de LUS en de NID (via de DeviceML port...vernisenigvuidigd! enlof openbaar gensaaki door middel van druk, fotokopie, microftinm of op welke andere wijze dan ook, zonder voorafgaande schrifielijke

Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases

PubMed Central

Meziane-Cherif, Djalal; Stogios, Peter J.; Evdokimova, Elena; Egorova, Olga

2015-01-01

ABSTRACT Vancomycin resistance in Gram-positive bacteria results from the replacement of the d-alanyl–d-alanine target of peptidoglycan precursors with d-alanyl–d-lactate or d-alanyl–d-serine (d-Ala-d-Ser), to which vancomycin has low binding affinity. VanT is one of the proteins required for the production of d-Ala-d-Ser-terminating precursors by converting l-Ser to d-Ser. VanT is composed of two domains, an N-terminal membrane-bound domain, likely involved in l-Ser uptake, and a C-terminal cytoplasmic catalytic domain which is related to bacterial alanine racemases. To gain insight into the molecular function of VanT, the crystal structure of the catalytic domain of VanTG from VanG-type resistant Enterococcus faecalis BM4518 was determined. The structure showed significant similarity to type III pyridoxal 5′-phosphate (PLP)-dependent alanine racemases, which are essential for peptidoglycan synthesis. Comparative structural analysis between VanTG and alanine racemases as well as site-directed mutagenesis identified three specific active site positions centered around Asn696 which are responsible for the l-amino acid specificity. This analysis also suggested that VanT racemases evolved from regular alanine racemases by acquiring additional selectivity toward serine while preserving that for alanine. The 4-fold-lower relative catalytic efficiency of VanTG against l-Ser versus l-Ala implied that this enzyme relies on its membrane-bound domain for l-Ser transport to increase the overall rate of d-Ser production. These findings illustrate how vancomycin pressure selected for molecular adaptation of a housekeeping enzyme to a bifunctional enzyme to allow for peptidoglycan remodeling, a strategy increasingly observed in antibiotic-resistant bacteria. PMID:26265719

Structural and functional adaptation of vancomycin resistance VanT serine racemases

DOE PAGES

Meziane-Cherif, Djalal; Stogios, Peter J.; Evdokimova, Elena; ...

2015-08-11

Vancomycin resistance in Gram-positive bacteria results from the replacement of the D-alanyl–D-alanine target of peptidoglycan precursors with D-alanyl–D-lactate or D-alanyl–D-serine (D-Ala-D-Ser), to which vancomycin has low binding affinity. VanT is one of the proteins required for the production of D-Ala-D-Ser-terminating precursors by converting L-Ser to D-Ser. VanT is composed of two domains, an N-terminal membrane-bound domain, likely involved in L-Ser uptake, and a C-terminal cytoplasmic catalytic domain which is related to bacterial alanine racemases. To gain insight into the molecular function of VanT, the crystal structure of the catalytic domain of VanT G from VanG-type resistant Enterococcus faecalis BM4518more » was determined. The structure showed significant similarity to type III pyridoxal 5'-phosphate (PLP)-dependent alanine racemases, which are essential for peptidoglycan synthesis. Comparative structural analysis between VanT G and alanine racemases as well as site-directed mutagenesis identified three specific active site positions centered around Asn 696 which are responsible for theL-amino acid specificity. This analysis also suggested that VanT racemases evolved from regular alanine racemases by acquiring additional selectivity toward serine while preserving that for alanine. The 4-fold-lower relative catalytic efficiency of VanT G against L-Ser versus L-Ala implied that this enzyme relies on its membrane-bound domain for L-Ser transport to increase the overall rate of D-Ser production. These findings illustrate how vancomycin pressure selected for molecular adaptation of a housekeeping enzyme to a bifunctional enzyme to allow for peptidoglycan remodeling, a strategy increasingly observed in antibiotic-resistant bacteria.« less

A discussion of the socio-economic losses and shelter impacts from the Van, Turkey Earthquakes of October and November 2011

NASA Astrophysics Data System (ADS)

Daniell, J. E.; Khazai, B.; Wenzel, F.; Kunz-Plapp, T.; Vervaeck, A.; Muehr, B.; Markus, M.

2012-04-01

The Van earthquake in 2011 hit at 10:41 GMT (13:41 Local) on Sunday, October 23rd, 2011. It was a Mw7.1-7.3 event located at a depth of around 10 km with the epicentre located directly between Ercis (pop. 75,000) and Van (pop. 370,000). Since then, the CEDIM Forensic Analysis Group (using a team of seismologists, engineers, sociologists and meteorologists) and www.earthquake-report.com has reported and analysed on the Van event. In addition, many damaging aftershocks occurring after the main eventwere analysed including a major aftershock centered in Van-Edremit on November 9th, 2011, causing much additional losses. The province of Van has around 1.035 million people as of the last census. The Van province is one of the poorest in Turkey and has much inequality between the rural and urban centers with an average HDI (Human Development Index) around that of Bhutan or Congo. The earthquakes are estimated to have caused 604 deaths (23 October) and 40 deaths (9 November); mostly due to falling debris and house collapse). In addition, between 1 billion TRY to 4 billion TRY (approx. 555 million USD - 2.2 billion USD) is estimated as total economic losses. This represents around 17 to 66% of the provincial GDP of the Van Province (approx. 3.3 billion USD) as of 2011. From the CATDAT Damaging Earthquakes Database, major earthquakes such as this one have occurred in the year 1111 causing major damage and having a magnitude around 6.5-7. In the year 1646 or 1648, Van was again struck by a M6.7 quake killing around 2000 people. In 1881, a M6.3 earthquake near Van killed 95 people. Again, in 1941, a M5.9 earthquake affected Ercis and Van killing between 190 and 430 people. 1945-1946 as well as 1972 brought again damaging and casualty-bearing earthquakes to the Van province. In 1976, the Van-Muradiye earthquake struck the border region with a M7, killing around 3840 people and causing around 51,000 people to become homeless. Key immediate lessons from similar historic earthquakes in eastern Turkey were developed in terms of the mass shelter and post-earthquake housing needs of the displaced population of Van. This included an analysis of shelter and reconstruction requirements under winter weather conditions; community resourcefulness in coping with housing needs through indigenous methods; and issues with in-place sheltering versus relocation and resettlement. A summary of the losses and implications on the GDP, economic dynamics, capital stock, social structure shelter and housing needs of the region is discussed. In addition, a quick comparison to past similar earthquakes is undertaken through the use of CATDAT.

Effect of Ion-Parallel Viscosity on the Propagation of Alfven Surface Waves

DTIC Science & Technology

2003-07-20

mode arises from 0.6 whose phase speed decreases with the in- 0 0.2 0.4 0.6 0.8 I crease in the value of the parameter V0. It is also Figure 2...after the value of 0.9. [3] R. Balescu , Transport Proccsses in Plasmas, Thus the modes of surface waves become damped North Holland, Amsterdam, 1 (1988

Beyond Access. Diversity and Opportunity in Higher Education. Proceedings of the Annual European Access Network (EAN) Convention (5th, Amsterdam, The Netherlands, July 1-3, 1996).

ERIC Educational Resources Information Center

de Bie, Marloes, Ed.; Derks, Bas, Ed.; Suikjer, Firiel, Ed.

This proceedings presents papers given at a 1996 European conference on access to higher education. Following two introductory papers are the following 13 plenary session papers: "A European Perspective" (James Wimberley); "An American Perspective--Diversity in American Higher Education and U.S. Federal Policy" (Tom Wolanin); "An Eastern European…

Materials Sciences Research.

DTIC Science & Technology

1974-07-01

12 12. Magnet Facility Two superconducting magnets are available. One has a capability of 125 kilogauss and the other provides 70 kilogauss with a...7. . . **. . . . . . . . . . 56 D. M. Ginsberg The Depression of the Superconducting Transition Temperature Caused by Iron-Group Magnetic ...MRL Seminar May 23, 1973 Magnetism Specific Heat and Resistivity of Ni3 Al and Ni 3Ga Dr. P. DeSchatel, University of Amsterdam, Holland 4 Metallurgy

Amsterdam to Nairobi: The World Council of Churches and the Third World.

ERIC Educational Resources Information Center

Lefever, Ernest W.

Churches, and in a larger sense religion, should serve as the conscience of society. Hence Christian bodies have an obligation to condemn gross evils and to speak out on the great moral issues, but they should not give their full support to any political party or cause. The World Council of Churches (WCC) from its beginning in 1948 showed an…

Reflections on Heckman and Pinto’s Causal Analysis After Haavelmo

DTIC Science & Technology

2013-11-01

Econometric Analysis , Cambridge University Press, 477–490, 1995. Halpern, J. (1998). Axiomatizing causal reasoning. In Uncertainty in Artificial...Models, Structural Models and Econometric Policy Evaluation. Elsevier B.V., Amsterdam, 4779–4874. Heckman, J. J. (1979). Sample selection bias as a...Reflections on Heckman and Pinto’s “Causal Analysis After Haavelmo” Judea Pearl University of California, Los Angeles Computer Science Department Los

Autonomic Mechanisms Associated with Heart Rate and Vasoconstrictor Reserves

DTIC Science & Technology

2011-11-15

hemodynamic decompensation (i.e., severe hypo- tension and pre-syncope) has revealed that subjects with high tolerance (HT) to reduced central blood ...electrical potentials, and an infrared finger photoplethysmograph (Finometer Blood Pressure Moni- tor, TNO-TPD Biomedical Instrumentation, Amsterdam...The Netherlands) to record beat-by-beat finger arterial pressure . The Finometer blood pressure cuff was placed on the middle finger of the left

Engagement in Self-Regulated Deep Learning of Successful Immigrant and Non-Immigrant Students in Inner City Schools

ERIC Educational Resources Information Center

Blom, Sarah; Severiens, Sabine

2008-01-01

In order to examine and explain differences in self-regulated (SR) deep learning of successful immigrant and non-immigrant students we investigated a population of 650 high track 10th grade students in Amsterdam, of which 39% had an immigrant background. By means of a questionnaire based on the MSLQ of Pintrich and De Groot (1990) the students…

Selected Bibliography on Optimizing Techniques in Statistics

DTIC Science & Technology

1981-08-01

problems in business, industry and .ogovern nt ae f rmulated as optimization problem. Topics in optimization constitute an essential area of study in...numerical, iii) mathematical programming, and (iv) variational. We provide pertinent references with statistical applications Sin the above areas in Part I...TMS Advanced Studies in Managentnt Sciences, North-Holland PIIENli iiiany, Amsterdam. (To appear.) Spang, H. A. (1962). A review of minimization

Promoting Learner Reflection: Issues and Difficulties Emerging from a Three-Year Study

DTIC Science & Technology

2002-12-01

and learning environments: Roles, structures, and implications for design. Educational Technology Research and Development, 43(2), 53-69. Clift... technology . No. 7. Amsterdam: Elsevier Schon, D (1987). Educating the reflective practitioner: Toward a new design for teaching and learning in...Situated learning and the culture of learning . Educational Researcher, 18(1), 32-42. Brown, J., & Duguid, P., (1993). Stolen Knowledge. Educational

Self-Awareness in Human and Chimpanzee Infants: What is Measured and What is Meant by the Mark and Mirror Test?

ERIC Educational Resources Information Center

Bard, Kim A.; Todd, Brenda K.; Bernier, Chris; Love, Jennifer; Leavens, David A.

2006-01-01

The objective study of self-recognition, with a mirror and a mark applied to the face, was conducted independently by Gallup (1970) for use with chimpanzees and monkeys, and by Amsterdam (1972) for use with infant humans. Comparative psychologists have followed the model (and assumptions) set by Gallup, whereas developmental psychologists have…

Concurrency Attacks and Defenses

DTIC Science & Technology

2016-10-04

Enter name(s) of person(s) responsible for writing the report, performing the research, or credited with the content of the report. The form of...Amsterdam Avenue New York, NY 10027-7003 Tel.: 212-939-7012 Fax: 212-666-0140 Email : junfeng@cs.columbia.edu 2. Research Objectives...Multithreaded programs are getting increasingly pervasive and critical. Unfortunately, they remain extremely difficult to write . This difficulty has led to

An Ethical Basis for Autonomous System Deployment

DTIC Science & Technology

2009-09-24

Discussion on Robo -Ethics, Amsterdam, NL, March 2008.GSU Neurophilosophy 20. Brown Bag Lunch Series, "Governing Lethal Behavior: Embedding Ethics in an...5. Implementation of responsibility advisor : An ethical permission responsibility advisor was prototyped and demonstrated in a manner fully...PTF_Interface_Final_Largev3.mpg • Demonstration of the Ethical Responsibility Advisor : http://www.cc.gatech.edu/ai/robot-lab/ethics/res-advisor.mpg

2 Professors Rock Out Online to Study Fame--and Us

ERIC Educational Resources Information Center

Young, Jeffrey R.

2009-01-01

Most people who stumble across the YouTube video of the self-proclaimed rock star Gory Bateson singing to a scantily clad prostitute in Amsterdam's red-light district probably have no idea that the work is part of a research project--or that the man holding the guitar is a tenured professor. The video has attracted more than 12,000 views and won a…

European College of Neuropsychopharmacology (ECNP) - 23rd Congress.

PubMed

Finn, David P

2010-11-01

The 23rd Congress of the European College of Neuropsychopharmacology (ECNP), held in Amsterdam, included topics covering new therapeutic developments in the field of neuropsychopharmacology. This conference report highlights selected presentations on potential psychotropic drug targets, the relationship between psychiatric disorders and pain, treatments for depression and anxiety disorders, the role of glucocorticoid receptors in memory consolidation, and the use of anticonvulsants in impulse disorders.

Micro Declared Language Policy or Not?: Language-Policy-Like Statements in the Rules of Procedure of the Rwandan Parliament

ERIC Educational Resources Information Center

Gafaranga, Joseph; Niyomugabo, Cyprien; Uwizeyimana, Valentin

2013-01-01

An invitation to integrate macro and micro level analyses has been extended to researchers as this integration is felt to be the way forward for language policy research (Ricento, Ideology, politics and language policies: Focus on english, John Benjamins, Amsterdam, 2000). In turn, the notion of 'micro' in language policy has been specified as…

Stirling Powered Van Progam overview

NASA Technical Reports Server (NTRS)

Shaltens, R. K.

1986-01-01

The Stirling Powered Van Program (SPVP) is a multiyear, multiphase program to evaluate the automotive Stirling engine (ASE) in Air Force vans under realistic conditions. The objective of the SPVP is to transfer to manufacturer and end user(s) (i.e., on the path to commercialization) the second-generation Mod 2 ASE upon completion of the Automotive Stirling Engine Program in 1987. In order to meet this objective, the SPVP must establish Stirling performance, integrity, reliability, durability and maintainability. The ASE program background leading to the van program is reviewed and plans for evaluating the kinematic Stirling engine in Air Force vans examined. Also discussed are the NASA technology transfers to industry that have been accomplished and those which are currently being developed.

The association between ethnicity and vaginal microbiota composition in Amsterdam, the Netherlands.

PubMed

Borgdorff, Hanneke; van der Veer, Charlotte; van Houdt, Robin; Alberts, Catharina J; de Vries, Henry J; Bruisten, Sylvia M; Snijder, Marieke B; Prins, Maria; Geerlings, Suzanne E; Schim van der Loeff, Maarten F; van de Wijgert, Janneke H H M

2017-01-01

To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior. DNA was extracted from self-sampled vaginal swabs and sequenced by Illumina MiSeq (16S rRNA gene V3-V4 region). The overall prevalence of VMBs not dominated by lactobacilli was 38.5%: 32.2% had a VMB resembling bacterial vaginosis and another 6.2% had a VMB dominated by Bifidobacteriaceae (not including Gardnerella vaginalis), Corynebacterium, or pathobionts (streptococci, staphylococci, Proteus or Enterobacteriaceae). The most prevalent VMB in ethnically Dutch women was a Lactobacillus crispatus-dominated VMB, in African Surinamese and Ghanaian women a polybacterial G. vaginalis-containing VMB, and in the other ethnic groups a L. iners-dominated VMB. After adjustment for sociodemographic, behavioral and clinical factors, African Surinamese ethnicity (adjusted odds ratio (aOR) 5.1, 95% confidence interval (CI) 2.1-12.0) and Ghanaian ethnicity (aOR 4.8, 95% CI 1.8-12.6) were associated with having a polybacterial G. vaginalis-containing VMB, and African Surinamese ethnicity with a L. iners-dominated VMB (aOR 2.8, 95% CI 1.2-6.2). Shorter steady relationship duration, inconsistent condom use with casual partners, and not using hormonal contraception were also associated with having a polybacterial G. vaginalis-containing VMB, but human papillomavirus infection was not. Other sexually transmitted infections were uncommon. The overall prevalence of having a VMB not dominated by lactobacilli in this population-based cohort of women aged 18-34 years in Amsterdam was high (38.5%), and women of sub-Saharan African descent were significantly more likely to have a polybacterial G. vaginalis-containing VMB than Dutch women independent of modifiable behaviors.

Health, drugs and service use among deprived single men: comparing (subgroups) of single male welfare recipients against employed single men in Amsterdam.

PubMed

Kamann, Tjerk C; de Wit, Matty A S; Cremer, Stephan; Beekman, Aartjan T F

2014-02-20

To aid public health policy in preventing severe social exclusion (like homelessness) and promoting social inclusion (like labour market participation), we aimed to quantify (unmet) health needs of an expectedly vulnerable population on which little was known about: single male welfare recipients (SIM-welfare). One of the main policy questions was: is there need to promote access to healthcare for this specific group? A cross-sectional study incorporating peer-to-peer methodology to approach and survey SIM-welfare. Sociodemographics, prevalence of ill health, harmful drug use and healthcare utilisation for subgroups of SIM-welfare assessed with a different distance to the labour market and exposed to different reintegration policy were described and compared against single employed men (SIM-work). Men between the age of 23 and 64, living in single person households in Amsterdam. A random and representative sample of 472 SIM-welfare was surveyed during 2009-2010. A reference sample of 212 SIM-work was taken from the 2008 Amsterdam Health Survey. Standardised instruments were used to assess self-reported ill somatic and mental health, harmful drug use and service use. SIM-welfare are mostly long-term jobless, low educated, older men; 70% are excluded from re-employment policy due to multiple personal barriers. Health: 50% anxiety and depression; 47% harmful drug use; 41% multiple somatic illnesses. Health differences compared with SIM-work: (1) controlled for background characteristics, SIM-welfare report more mental (OR 4.0; 95% CI 2.1 to 4.7) and somatic illnesses (OR 3.1; 95% CI 2.7 to 6.0); (2) SIM-welfare assessed with the largest distance to the labour market report most combined health problems. Controlled for ill health, SIM-welfare are more likely to have service contacts than SIM-work. SIM-welfare form a selection of men with disadvantaged human capital and health. Findings do not support a need to improve access to healthcare. The stratification of welfare clients distinguishes between health needs.

An Imaging Biomarker for Assessing Hepatic Function in Patients with Primary Sclerosing Cholangitis.

PubMed

Schulze, Jennifer; Lenzen, Henrike; Hinrichs, Jan B; Ringe, Burckhardt; Manns, Michael P; Wacker, Frank; Ringe, Kristina I

2018-05-15

We aimed to evaluate the potential of hepatobiliary phase magnetic resonance imaging (MRI) as parameter for assessment of hepatocellular function in patients with primary sclerosing cholangitis (PSC). We collected data from 111 patients (83 male, 28 female; median, 44 years old), from March 2012 through March 2016, with a confirmed diagnosis of PSC who underwent MRI evaluation before and after injection (hepatobiliary phase) of a hepatocyte-specific contrast agent (gadoxetate disodium). Signal intensities were measured in each liver segment. Mean relative enhancement values were calculated and correlated with findings from liver functions tests, prognostic scoring systems (model for end-stage liver disease [MELD] score; Mayo risk score; Amsterdam-Oxford-PSC score), abnormalities detected by endoscopic retrograde cholangiopancreatography (using the Amsterdam cholangiographic classification system), and clinical endpoints (liver transplantation, cholangiocarcinoma, liver-related death). Our primary aim was to associate relative enhancement values with liver function and patient outcomes. Most patients had moderate-stage disease and had intermediate levels of risk (median MELD score, 8 and median Mayo score, 0.27). Clinical endpoints were reached by 21 patients (6 developed cholangiocarcinoma, 8 underwent liver transplantation, and 7 patients died). The highest levels of correlations were observed for relative enhancement 20 min after contrast injection and level of alkaline phosphatase (r= -0.636), bilirubin (r= -0.646), albumin (r= 0.538); as well as international normalized ratio (r=0.456); MELD score (r= -0.587); Mayo risk score (r= -0.535), and Amsterdam-Oxford model score (r= -0.595) (P<.0001). Relative enhancement correlated with all clinical endpoints (all P<.05). A cutoff relative enhancement value of 0.65 identified patients with a clinical endpoint with 73.9% sensitivity 92.9% specificity (area under the receiver operating characteristic curve, 0.901; likelihood ratio, 10.34; P<.0001). In an analysis of 111 patients with PSC, we found MRI-measured relative enhancement, using a hepatocyte-specific contrast agent, to identify patients with clinical outcomes with 73.9% sensitivity 92.9% specificity. Long-term, multicenter studies are needed to further evaluate this marker of PSC progression. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

Incidence of cancer in the area around Amsterdam Airport Schiphol in 1988-2003: a population-based ecological study.

PubMed

Visser, Otto; van Wijnen, Joop H; van Leeuwen, Flora E

2005-12-06

Amsterdam Airport Schiphol is a major source of complaints about aircraft noise, safety risks and concerns about long term adverse health effects, including cancer. We investigated whether residents of the area around Schiphol are at higher risk of developing cancer than the general Dutch population. In a population-based study using the regional cancer registry, we estimated the cancer incidence during 1988-2003 in residents of the area surrounding Schiphol. We defined a study area based on aircraft noise contours and 4-digit postal code areas, since historical data on ambient air pollution were not available and recent emission data did not differ from the background urban air quality. In residents of the study area 13 207 cancer cases were diagnosed, which was close to the expected number, using national incidence rates as a reference (standardized incidence ratio [SIR] 1.02). We found a statistically significantly increased incidence of hematological malignancies (SIR 1.12, 95% confidence interval [CI]: 1.05, 1.19), mainly due to high rates for non-Hodgkin lymphoma (SIR 1.22, 95% CI: 1.12, 1.33) and acute lymphoblastic leukemia (SIR 1.34, 95% CI: 0.95, 1.83). The incidence of cancer of the respiratory system was statistically significantly decreased (SIR 0.94, 95% CI: 0.90, 0.99), due to the low rate in males (SIR 0.89). In the core zone of the study area, cancer incidence was slightly higher than in the remaining ring zone (rate ratio of the core zone compared to the ring zone 1.05, 95% CI 1.01, 1.10). This was caused by the higher incidence of cancer of the respiratory system, prostate and the female genital organs in the core zone in comparison to the ring zone. The overall cancer incidence in the Schiphol area was similar to the national incidence. The moderately increased risk of hematological malignancies could not be explained by higher levels of ambient air pollution in the Schiphol area. This observation warrants further research, for example in a study with focus on substances in urban ambient air pollution, as similar findings were observed in Greater Amsterdam.

Health, drugs and service use among deprived single men: comparing (subgroups) of single male welfare recipients against employed single men in Amsterdam

PubMed Central

Kamann, Tjerk C; de Wit, Matty A S; Cremer, Stephan; Beekman, Aartjan T F

2014-01-01

Objectives To aid public health policy in preventing severe social exclusion (like homelessness) and promoting social inclusion (like labour market participation), we aimed to quantify (unmet) health needs of an expectedly vulnerable population on which little was known about: single male welfare recipients (SIM-welfare). One of the main policy questions was: is there need to promote access to healthcare for this specific group? Design A cross-sectional study incorporating peer-to-peer methodology to approach and survey SIM-welfare. Sociodemographics, prevalence of ill health, harmful drug use and healthcare utilisation for subgroups of SIM-welfare assessed with a different distance to the labour market and exposed to different reintegration policy were described and compared against single employed men (SIM-work). Setting Men between the age of 23 and 64, living in single person households in Amsterdam. Participants A random and representative sample of 472 SIM-welfare was surveyed during 2009–2010. A reference sample of 212 SIM-work was taken from the 2008 Amsterdam Health Survey. Outcome measures Standardised instruments were used to assess self-reported ill somatic and mental health, harmful drug use and service use. Results SIM-welfare are mostly long-term jobless, low educated, older men; 70% are excluded from re-employment policy due to multiple personal barriers. Health: 50% anxiety and depression; 47% harmful drug use; 41% multiple somatic illnesses. Health differences compared with SIM-work: (1) controlled for background characteristics, SIM-welfare report more mental (OR 4.0; 95% CI 2.1 to 4.7) and somatic illnesses (OR 3.1; 95% CI 2.7 to 6.0); (2) SIM-welfare assessed with the largest distance to the labour market report most combined health problems. Controlled for ill health, SIM-welfare are more likely to have service contacts than SIM-work. Conclusions SIM-welfare form a selection of men with disadvantaged human capital and health. Findings do not support a need to improve access to healthcare. The stratification of welfare clients distinguishes between health needs. PMID:24556242

Conversion of Chemical Reaction Energy into Useful Work in the Van't Hoff Equilibrium Box

ERIC Educational Resources Information Center

Bazhin, N. M.; Parmon, V. N.

2007-01-01

The ideal van't Hoff equilibrium box is described in detail. It shows that van't Hoff equilibrium box divided in two parts can simultaneously produce heat and useful work without violation of the first law of thermodynamics.

Genetics Home Reference: van der Woude syndrome

MedlinePlus

... What is the prognosis of a genetic condition? Genetic and Rare Diseases Information Center Frequency Van der Woude syndrome is believed to occur in 1 in 35,000 to 1 in 100,000 people, based on data from Europe and Asia. Van der Woude syndrome ...

A New Method for Suppressing Periodic Narrowband Interference Based on the Chaotic van der Pol Oscillator

NASA Astrophysics Data System (ADS)

Lu, Jia; Zhang, Xiaoxing; Xiong, Hao

The chaotic van der Pol oscillator is a powerful tool for detecting defects in electric systems by using online partial discharge (PD) monitoring. This paper focuses on realizing weak PD signal detection in the strong periodic narrowband interference by using high sensitivity to the periodic narrowband interference signals and immunity to white noise and PD signals of chaotic systems. A new approach to removing the periodic narrowband interference by using a van der Pol chaotic oscillator is described by analyzing the motion characteristic of the chaotic oscillator on the basis of the van der Pol equation. Furthermore, the Floquet index for measuring the amplitude of periodic narrowband signals is redefined. The denoising signal processed by the chaotic van der Pol oscillators is further processed by wavelet analysis. Finally, the denoising results verify that the periodic narrowband and white noise interference can be removed efficiently by combining the theory of the chaotic van der Pol oscillator and wavelet analysis.

Van der Waals interaction in uniaxial anisotropic media.

PubMed

Kornilovitch, Pavel E

2013-01-23

Van der Waals interactions between flat surfaces in uniaxial anisotropic media are investigated in the nonretarded limit. The main focus is the effect of nonzero tilt between the optical axis and the surface normal on the strength of the van der Waals attraction. General expressions for the van der Waals free energy are derived using the surface mode method and the transfer-matrix formalism. To facilitate numerical calculations a temperature-dependent three-band parameterization of the dielectric tensor of the liquid crystal 5CB is developed. A solid slab immersed in a liquid crystal experiences a van der Waals torque that aligns the surface normal relative to the optical axis of the medium. The preferred orientation is different for different materials. Two solid slabs in close proximity experience a van der Waals attraction that is strongest for homeotropic alignment of the intervening liquid crystal for all the materials studied. The results have implications for the stability of plate-like colloids in liquid crystal hosts.

Van, Turkey Earthquake of 23 October 2011, Mw 7.2; An Overview on Disaster Management

PubMed Central

ZARÉ, Mehdi; NAZMAZAR, Behnaz

2013-01-01

An earthquake was happened on 23 October 2011 in Van, Turkey (Mw7.2) at the eastern most area of Anatolian plateau and in the neighborhood of Iranian border (West Azerbaijan Province). The study was performed based on field and office observations and has been focused on the process of disaster management in Turkey after the 23 October 2011 earthquake. We surveyed the quake from the view point of disaster management, and study the relief process during and after the catastrophe. The day-to-day disaster management procedure in seventeen days after the event has been scrutinized as well. The number of victims and extent of damage in Van earthquake was relatively limited according to the national experiences and recent modernization of infrastructures in Turkey. The Van earthquake caused 644 deaths and demolishing of several buildings in the cities of Van and Erciş in Van Province. The performance of the government organizations is however criticized based on their response to the event. PMID:23515082

Evolution of novel O-methyltransferases from the Vanilla planifolia caffeic acid O-methyltransferase.

PubMed

Li, Huaijun Michael; Rotter, David; Hartman, Thomas G; Pak, Fulya E; Havkin-Frenkel, Daphna; Belanger, Faith C

2006-06-01

The biosynthesis of many plant secondary compounds involves the methylation of one or more hydroxyl groups, catalyzed by O-methyltransferases (OMTs). Here, we report the characterization of two OMTs, Van OMT-2 and Van OMT-3, from the orchid Vanilla planifolia Andrews. These enzymes catalyze the methylation of a single outer hydroxyl group in substrates possessing a 1,2,3-trihydroxybenzene moiety, such as methyl gallate and myricetin. This is a substrate requirement not previously reported for any OMTs. Based on sequence analysis these enzymes are most similar to caffeic acid O-methyltransferases (COMTs), but they have negligible activity with typical COMT substrates. Seven of 12 conserved substrate-binding residues in COMTs are altered in Van OMT-2 and Van OMT-3. Phylogenetic analysis of the sequences suggests that Van OMT-2 and Van OMT-3 evolved from the V. planifolia COMT. These V. planifolia OMTs are new instances of COMT-like enzymes with novel substrate preferences.

Reply to “Statistical evaluation of the VAN Method using the historic earthquake catalog in Greece,” by Richard L. Aceves, Stephen K. Park and David J. Strauss

NASA Astrophysics Data System (ADS)

Varotsos, P.; Lazaridou, M.

The pioneering calculation by Aceves et al. [1996] shed light on the main question of this debate, i.e., on whether “VAN predictions can be ascribed to chance.” Aceves et al. [1996] conclude that “the VAN method has resulted in a significantly higher prediction rate than randomly sampling a PDF (probability density function) map generated from a 25 year history of earthquakes.” After investigating the totality of VAN predictions issued during the period 1987-1989, Aceves et al. [1996] found: “The prediction rate for the VAN method clearly exceeds that from the random model at all time lags between 5-22 days. At a 5 day time lag, the VAN prediction rate of 35.7% has a P-value of less than 0.06%. This means that a random model does as well as does the VAN method less than 0.06% of the time. At 22 days, the prediction rate of 67.9% has a P-value of less than 0.07%.” These conclusions basically coincide with those of Hamada [1993] although Aceves et al. [1996] followed different procedures. They are also in fundamental agreement with the results of Honkura and Tanaka [1996]. Another important conclusion of Aceves et al. [1996] is that, after declustering the earthquake catalog and prediction list from aftershocks, “VAN method is still formally significant.”

[Implementation of vanA and vanB genes by PCR technique research interest in system (Xpert vanA/vanB CepheidR) closed in a laboratory of microbiology in managing an outbreak to Enterococcus faecium resistant glycopeptide (EfRG)].

PubMed

Dekeyser, S; Beclin, E; Descamps, D

2011-04-01

The closed system PCR for the rapid detection of vanA and vanB genes (Xpert vanA/vanB Cepheid(®)) was evaluated in our laboratory, to improve the rapidity of the response and thus the management of patients and isolation measures during two GRE outbreaks. From March to December2009, 565 samples were analysed by PCR associated to bacterial culture initially for all samples for 2months (n = 75), and thereafter for PCR-positive samples only. In this study, sensitivity and negative predictive values of the PCR were 100%. Specificity was evaluated in the presence and absence of outbreak: 69.3 and 76.8% respectively. The variability of false positive rates between units were lower in nonepidemic than during epidemic phase. The global false positive rate was 23.9%. This easy-to-use technology provides rapid results… four samples are tested in 1h versus 72h for culture. Despite its reagent cost, it represents an important hospital diagnostic tool: improvement of the management of cohorting areas and patient transfer between units, adaptation of isolation measures and treatments. However, culture remains necessary to confirm any positive result obtained by PCR and for epidemiological surveillance. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Genetics Home Reference: Ellis-van Creveld syndrome

MedlinePlus

... CREVELD SYNDROME Sources for This Page Baujat G, Le Merrer M. Ellis-van Creveld syndrome. Orphanet J Rare Dis. 2007 Jun ... CB, Kochilas L, Schimmenti LA, Moller JH. Ellis-van Creveld syndrome and congenital heart defects: presentation of an additional 32 cases. Pediatr Cardiol. 2011 Oct;32( ...

Testing the dynamic rollover resistance of two 15-passenger vans with multiple load configurations

DOT National Transportation Integrated Search

2004-06-01

As a consequence of NTSB Safety Recommendations H-02-26 and H-02-28, NHTSA performed a study to investigate the effects different load conditions may have on the dynamic rollover resistance of 15-passenger vans. The two vans used in this study, a 200...

IKK and (Beta) - Catenin in Breast Cancer

DTIC Science & Technology

2004-07-01

signaling activity. Earlier data generated from the Byers lab have shown that phosphorylation of certain serine residues in the N-terminal of 13...ligand specificity. Cancer Res 60:4709-4713. 58. van de Wetering, M., R. Cavailo, D. Dooijes, M. van Beest , J. van Es, J. Louriero, A. Ypma, D. Hursh

Jao Van De Lagemaat | NREL

Science.gov Websites

Jao Van De Lagemaat Photo of Jao Vandelagemaat. Jao Van De Lagemaat Center Director: Chemistry and Lagemaat is currently the Center Director of the Chemistry and Nanoscience Center at NREL. He received his university. Education Ph.D. Physical Chemistry, University of Utrecht Featured Publications View all NREL

Is Progressive Education Obsolete: A Reconsideration.

ERIC Educational Resources Information Center

Beineke, John A.

1993-01-01

Van Til's 1962 article on whether or not progressive education is obsolete was a response to charges that the new education as espoused by Dewey was outmoded. This paper reexamines Van Til's article and suggests a prognostication similar to Van Til's could be ventured today that another period of progressivism is inevitable. (SM)

A Conversation with William Van Til.

ERIC Educational Resources Information Center

Beineke, John A.

1989-01-01

Reports an interview with William Van Til, Coffman Distinguished Professor Emeritus of Education at Indiana State University (Terre Haute). Van Til reviews his career as a social studies teacher and his writings on curriculum and social foundations. Presents his opinions on progressive education, famous educators, educational history and reform,…

Assuring Safety in Bus Transportation--Update on Federal Legislation.

ERIC Educational Resources Information Center

Craft, Nick

2003-01-01

Discusses the growing use of vans for transportation by child care centers and increasing concerns about van safety. Presents information on relevant federal legislation related to motor vehicle safety and the safety standards of the National Highway Traffic Safety Administration. Recommends that child care programs replace retiring vans with…

Basic Research in Electronics (JSEP)

DTIC Science & Technology

1991-12-01

Single Crystal Growth Single crystals of Bi2Sr 2 CaCu2 O8 (BSCCO) have been prepared following the method of Mitzi , et al. [241. A mixture of oxides...P.C. van Son, H. van Kempen and P. Wyder, Phys. Rev. Lett., 50 2226 (1987). [24] D.B. Mitzi , L.W. Lombardo, A. Kapitulnik,/S.S. Laderman and R.D...Phys. Rev., 165 837 (1908). P.C. van Son, H. van Kempen and P. Wyder, Phys. Rev. Lett., 59 2228 (1987). D.B. Mitzi , L.W. Lombardo, A. Kapitulnik

Nanotechnology-Enabled Optical Molecular Imaging of Breast Cancer

DTIC Science & Technology

2012-07-01

Jacobus J M van Der Hoeven, Elsken van Der Wall, Petra van Der Groep, Paul J van Diest, Emile F I Comans, Urvi Joshi, et al. 2002. “Biologic correlates...William B Farrar, and Edward W Martin . 2008. “Novel perioperative imaging with 18F-FDG PET/CT and intraoperative 18F-FDG detection using a handheld gamma...n752170246r84660/. Hall, Nathan C, Stephen P Povoski, Douglas A Murrey, Michael V Knopp, and Edward W Martin . 2007. “Combined approach of perioperative 18F-FDG PET

Dynamical property analysis of fractionally damped van der pol oscillator and its application

NASA Astrophysics Data System (ADS)

Zhong, Qiuhui; Zhang, Chunrui

2012-01-01

In this paper, the fractionally damped van der pol equation was studied. Firstly, the fractionally damped van der pol equation was transformed into a set of integer order equations. Then the Lyapunov exponents diagram was given. Secondly, it was transformed into a set of fractional integral equations and solved by a predictor-corrector method. The time domain diagrams and phase trajectory were used to describe the dynamic behavior. Finally, the fractionally damped van der pol equation was used to detect a weak signal.

Investigation of Gene Expression Correlating With Centrosome Amplification in Development and Progression of Breast Cancer

DTIC Science & Technology

2004-09-01

M. A., Broerse, J. J., deVries, J. B., vandenBerg, K. K., Knaan, 33. Papa, D., Li, S. A. & Li, J. J. (2003) Mol. Carcinog. 38, 97-105. S. & van der ...Veer LI, Dai H, van de Vijver MJ, et al. Gene (n = 84). These data are similar to those of van de expression profiling predicts clinical outcome of...breast Vijver et al,"O who demonstrated a significant cancer. Nature 2002;415:530-536. correlation between outcome and expression of 70 10 van de Vijver

Bepaling Referentiewaarden voor Ergonomie en Warmtebelasting van Lichtgewicht Bommenpakken (Determination of Ergonomic and Thermal Load Tests and Assessment of Reference Values With Light Weight Bomb Disposal Suits)

DTIC Science & Technology

2008-05-01

bommenpakken kunnen geven bij bewegingen worden gemeten met de volgende bewegingbeperkingtests: sit-and-reach, stand-and-reach, abductie van de armen ...anteflexie van de armen en beperking van zicht. Bij de sit-and-reach test komt een eventuele belernmering bij het voorover buigen naar voren. De...proefpersoon zit op de grond met de benen en armen gestrekt naar voren. Daarbij wordt de afstand tussen de tenen en de vingers gemeten (figuur 4). Als het pak

A notable difference between ideal gas and infinite molar volume limit of van der Waals gas

NASA Astrophysics Data System (ADS)

Liu, Q. H.; Shen, Y.; Bai, R. L.; Wang, X.

2010-05-01

The van der Waals equation of state does not sufficiently represent a gas unless a thermodynamic potential with two proper and independent variables is simultaneously determined. The limiting procedures under which the behaviour of the van der Waals gas approaches that of an ideal gas are letting two van der Waals coefficients be zero rather than letting the molar volume become infinitely large; otherwise, the partial derivative of internal energy with respect to pressure at a fixed temperature does not vanish.

Trajectory Simulation Model for a Side- Thruster Guided MLRS-Type Vehicle

DTIC Science & Technology

1999-05-01

km halen . Voor de toekomst heeft men behoefte aan een dracht van ongeveer 60 km. Het is de doelstelling van opdracht A95KL410 om kennis en inzicht...G.M.H.J.L. Gadiot Datum mei 1999 Opdrachtnr. A95KL410 Rapportnr. PML 1998-A80 Figuur M.I.- Lancering van een M26-raket vanaf een MLRS ’launcher’. De...Koninklijke Nederlandse Landmacht (KL) heeft het ’Multiple Launcher Rocket System’ (MLRS) in gebruik. Met de huidige uitrusting kan men een dracht van 30

Geographical Information Extraction With Remote Sensing. Part I - Main Report.

DTIC Science & Technology

1998-08-01

Oude Waalsdorperweg 63 Date P0 Box 96864 2509 JG The Hague August 1998 The Netherlands Author(s) Phone +31 70 374 00 00 Dr A.C. van den Broek Fax +31 70...328 09 61 M. van Persie H.H.S. Noorbergen Dr G.J. Rijckenberg SSponsor HWO-COfHWO-KL N E R Project officer J. Rogge Affiliation KIN/IA - i All...Main report Auteur(s) Dr. A.C. van den Broek, Ir. M. van Persie, Ing. H.H.S. Noorberg~en, Dr. G.J. Rijkenberg Datum augustus 1998 Opdrachtnr

Kennislacunes op het gebied van wapens en munitie in OVG (Knowledge Gaps in the Area of Weapons and Munitions in MOUT)

DTIC Science & Technology

2008-12-01

Structuur 6 2.2 Inzetketen 8 2.3 Combinaties van W&M en doelen 9 2.4 Militaire activiteiten 10 3 De OVG context 11 4 Kennislacunes wapens en...Aanlal pagina’s Aantal bijlagen Ongerubriceerd drs. R.G.W. Gouweleeuw 7 november 2008 11 )eze mbricering \\N ijzigl mci) Ongerubriceerd...TNO-rapport | TNO-DV 2008 A436 9 /24 2.3 Combinaties van W&M en doelen In [2] is een overzicht opgesteld van zogenoemde ’force assets’ die tegen

Geautomatiseerde Verwerking van Militaire berichten Volgens ADatP-3 (Automated Processing of Military Messages According to ADatP-3)

DTIC Science & Technology

1992-06-01

ATCCIS beoogt juist dat te bereiken door te werken aan ecn informatie model en een data element dictionary. TNO-rapport Pagina 9 Binnen bet C2...en distributie 44 4.3.2 Interface met de gebruiker 45 4.3.3 Interface met dc operationcle database 46 TNO-rapport Pagina 11 4.3.3.1 Interpretatie...die bezig zijn met het ontwikkelen en implementeren van berichtformaten. Deel I van de publicatie bevat de beschrijving van FORMETS, delen 11 , I11 en

Jacobus Schroeder van der Kolk (1797-1862): his resistance against materialism.

PubMed

Eling, P

1998-07-01

Schroeder van der Kolk is regarded as the founder of Dutch psychiatry and neurology. This paper describes his vitalistic views on the relation between body and soul, as formulated by him in a series of lectures. These lectures were intended to counteract the materialistic tendencies of some of Schroeder van der Kolk's French and German contemporaries. It is argued that Schroeder van der Kolk can be regarded as the transition in Holland from the "Naturphilosophie" approach to the modern experimental approach in physiology. Copyright 1998 Academic Press.

J. H. Van Vleck and Magnetism at the University of Wisconsin: 1928 -1934

NASA Astrophysics Data System (ADS)

Huber, David

2011-03-01

In 1928, John Van Vleck returned to his alma mater to take a position in the Physics Department. Six years later he left to join the faculty of Harvard University. While Van Vleck was at Wisconsin, he began a series of theoretical studies that helped lay the foundation for the modern theory of magnetism in solids. In 1932 Van Vleck published his celebrated monograph, The Theory of Electric and Magnetic Susceptibilities, in which he made use of the new theory to explain the results of experimental studies in a variety of magnetic materials. In my talk, I will review the accomplishments of Van Vleck and his students during this period and also comment briefly on his notes for a second edition of the book.

Margaret Cavendish's materialist critique of van Helmontian chymistry.

PubMed

Clucas, Stephen

2011-03-01

A striking omission in the scholarship on the reception of the chymical philosophy of Jan Baptista van Helmont in England in the seventeenth century is the work of the mid-seventeenth-century natural philosopher Margaret Cavendish, Duchess of Newcastle. In her Philosophical Letters (1664), Cavendish offers an extended critique of Van Helmont's work (whose Ortus Medicince had recently been translated into English by John Sadler). In this paper, I compare Cavendish's criticisms with those of Robert Boyle in his Sceptical Chymist (1661). Both Boyle and Cavendish attacked Van Helmont for the obscurity of his chymical vocabulary and concepts, and attacked his seminalism. Although their critiques had much in common, they diverged in their attitudes to Van Helmont's experiments. As an opponent of the experimental philosophy, Cavendish had little interest in the quality of Van Helmont's experimental claims, whereas Boyle was critical of their unreplicability. I also try to show that the two writers had very different polemical agendas, with Boyle defending his vision of chymistry based on a corpuscularian natural philosophy, and Cavendish being as much concerned with establishing her religious orthodoxy as with defending the truth claims of her own materialist vitalism. For Cavendish, Van Helmont was an example of the dangers of mingling theology and natural philosophy.

Mammograms on-the-go-predictors of repeat visits to mobile mammography vans in St Louis, Missouri, USA: a case-control study.

PubMed

Drake, Bettina F; Abadin, Salmafatima S; Lyons, Sarah; Chang, Su-Hsin; Steward, Lauren T; Kraenzle, Susan; Goodman, Melody S

2015-03-20

Among women, breast cancer is the most common non-cutaneous cancer and second most common cause of cancer-related death. The purpose of this study was to determine the extent to which women use mobile mammography vans for breast cancer screening and what factors are associated with repeat visits to these vans. A case-control study. Cases are women who had a repeat visit to the mammography van. (n=2134). Women who received a mammogram as part of Siteman Cancer Center's Breast Health Outreach Program responded to surveys and provided access to their clinical records (N=8450). Only visits from 2006 to 2014 to the mammography van were included. The main outcome is having a repeat visit to the mammography van. Among the participants, 25.3% (N=2134) had multiple visits to the mobile mammography van. Data were analysed using χ(2) tests, logistic regression and negative binomial regression. Women who were aged 50-65, uninsured, or African-American had higher odds of a repeat visit to the mobile mammography van compared with women who were aged 40-50, insured, or Caucasian (OR=1.135, 95% CI 1.013 to 1.271; OR=1.302, 95% CI 1.146 to 1.479; OR=1.281, 95% CI 1.125 to 1.457), respectively. However, the odds of having a repeat visit to the van were lower among women who reported a rural ZIP code or were unemployed compared with women who provided a suburban ZIP code or were employed (OR=0.503, 95% CI 0.411 to 0.616; OR=.868, 95% CI 0.774 to 0.972), respectively. This study has identified key characteristics of women who are either more or less likely to use mobile mammography vans as their primary source of medical care for breast cancer screening and have repeat visits. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

An Exploratory Analysis of the Relationship between Media Richness and Managerial Information Processing

DTIC Science & Technology

1984-07-01

engineers use technology to design optimal information systems that will provide clear, correct data to help managers solve current problems (Keen...is in a changing environment (Hedberg and Jonsson, 1978; Mowshowitz, 1976; Hedberg, 1981; Hedberg, Nystrom, and Starbuck , 1976). Technology based...organizations learn and unlearn." In P. C. Nystrom, and W. H. Starbuck (eds.), Handbook of Organizational Design, Vol. 1. Amsterdam: Elsevier Scientific

Effect of genetic strain and gender on age-related changes in body composition of the laboratory rat.

EPA Pesticide Factsheets

Body composition data for common laboratory strains of rat as a function of age.This dataset is associated with the following publication:Gordon , C., K. Jarema , A. Johnstone , and P. Phillips. Effect of Genetic Strain and Gender on Age-Related Changes in Body Composition of the Laboratory Rat. Physiology & Behavior. Elsevier B.V., Amsterdam, NETHERLANDS, 153(1): 56-63, (2016).

AFRRI Reports Third Quarter, July - September 1991

DTIC Science & Technology

1991-10-01

provide useful phenotypic markers for the different (36). Only one t pe of outwvard voltage-dependent K con- cell types. In vivo T-cell activation is...Graftitng its [ie In A. Bjorklund and U. Stent% tLds .). NVeural Grafting tin t/e Alaminulian CXVS. Elsevier, Amsterdam. 1985. pp. 41-49. Malinmalian LN.S...factor traceable to the National Institute of transormaion.Standards and Trechnology (29). The dosimetry measurements were per- oncogene-induced

Bacteria, fungi and protozoa paper

EPA Pesticide Factsheets

Bacteria and fungi in source and treated drinking waterThis dataset is associated with the following publication:King , D., S. Pfaller , M. Donohue , S. Vesper , E. Villegas , M. Ware , S. Glassmeyer , M. Vogal, E. Furlong, and D. Kolpin. Microbial pathogens in source and treated waters from drinking water treatment plants in the United States and implications for human health. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, NETHERLANDS, 562: 987–995, (2016).

Chance Constrained Programming Methods in Probabilistic Programming.

DTIC Science & Technology

1982-03-01

Financial and Quantitative Analysis 2, 1967. Also reproduced in R. F. Byrne et. al., eds.5tudies in Budgeting (Amsterdam: North Holland, 1971 ). [3...Rules for the E-Model of Chance-Constrained Programming," Management Science, 17, 1971 . [23] Garstka, S. J. "The Economic Equivalence of Several...Iowa City: The University of Iowa College of Business Administration, 1981). -3- (29] Kall , P. and A. Prekopa, eds, Recent Results in Stochastic

Matching Extension in Regular Graphs

DTIC Science & Technology

1989-01-01

Plummer, Matching Theory, Ann. Discrete Math . 29, North- Holland, Amsterdam, 1986. [101 , The matching structure of graphs: some recent re- sults...maximums d’un graphe, These, Dr. troisieme cycle, Univ. Grenoble, 1978. [12 ] D. Naddef and W.R. Pulleyblank, Matching in regular graphs, Discrete Math . 34...1981, 283-291. [13 1 M.D. Plummer, On n-extendable graphs, Discrete Math . 31, 1980, 201-210. . [ 141 ,Matching extension in planar graphs IV

Muscle Sympathetic Nerve Activity During Intense Lower Body Negative Pressure to Presyncope in Humans

DTIC Science & Technology

2009-08-24

frequency rhythms. Arterial pressure oscillations increase with reductions in central blood volume induced by haemorrhage (Guyton & Harris, 1951), head...a finger cuff to record beat-by-beat finger arterial pressure (Finometer Blood Pressure Monitor, TNO-TPD Biomedical Instrumentation, Amsterdam, The...experienced reductions in arterial pressure at presyncope. The lowest blood pressures recorded for each subject are shown in the upper right of each

Rethinking US Security Policy for the 1980s. Proceedings of the Annual National Security Affairs Conference (7th) held 21-23 July 1980, Fort McNair, Washington, DC.

DTIC Science & Technology

1980-01-01

years. The Bible , in both the Old and New Testaments, is generally regarded as written by authors inspired by God but with only those passages so...Northwestern, Stanford, the University of Amsterdam, and annually for 6 years at the Hebrew Univer- sity of Jerusalem. He has lectured throughout Europe

Excellence and Diversity: The Emergence of Selective Admission Policies in Dutch Higher Education--A Case Study on Amsterdam University College. Research & Occasional Paper Series: CSHE.15.10

ERIC Educational Resources Information Center

Reumer, Christoffel; van der Wende, Marijk

2010-01-01

This paper explores the emergence of selective admission policies in Dutch university education. Such policies are being developed to promote excellence in a higher education system that is generally known to be "egalitarian" and increasingly criticized for a lack of differentiation. The changing policy context of admission in Dutch…

The University of Amsterdam at TREC 2012

DTIC Science & Technology

2012-11-01

lady , weight, ap, loss, major, insurance, rate, role, response, plays, atlanta, rising, oprah, childhood, crescent Table 5: Example topics and their...by the CLARIN-nl program, the Dutch national program COMMIT, the ESF Research Net- work Program ELIAS, the Elite Network Shifts project funded by the...Royal Dutch Academy of Sciences (KNAW), and the Netherlands eScience Center under project number 027.012.105. 6 References [1] Balasubramanian, N. and

Two Week Oral Dose Range-Finding Toxicity Study of WR269410 in Rats

DTIC Science & Technology

1993-07-09

Part 2. IFCC Method for Aspartate Aminotransferase, Amsterdam, Elsevier Scientific Publishing Company (1975) Alanine Aminotransferase (ALT/GPT... IDENTIFICATION NUMBER DAMD17-92-C-2001 [8c ADDRESS (City, State, and ZIP Code) Fort Detrick Frederick, MD 21702-5009 10. SOURCE OF FUNDING NUMBERS...STATEMENT 3 SIGNATURE PAGE 4 TABLE OF CONTENTS 5 1. SUMMARY 7 2. INTRODUCTION 7 3. MATERIALS AND METHODS 7 3.1 Test

Analyzing Divisia Rules Extracted from a Feedforward Neural Network

DTIC Science & Technology

2006-03-01

assumptions. (Barnett and work, Data Mining, Rule Generation Serletis give a detailed treatment of the the- ory of monetary aggregation [1].) However, 1... Serletis , A. (Eds.) (2000), The The- Swizerland, 1995. ory of Monetary Aggregation, North-H ollandeAmsterdam, Chgaptero , pp.- [11] Vincent A. Schmidt and...gas, Nevada, 2002. sets. Macroeconomic Dynamics, 1:485-512, 1997. Reprinted in Barnett, WA. [12] Vincent A. Schmidt and Jane M. Binner. and Serletis

A. E. van Vogt: In Search of Meaning.

ERIC Educational Resources Information Center

Drake, H. L.

A general semantics perspective of science fiction writer A. E. van Vogt is presented in this paper. The first major section of the paper contains a biographical sketch of van Vogt and traces the influence of A. Korzybski's work on general semantics, "Science and Sanity," on his writing, while the second major section provides an…

Motion Sickness When Driving With a Head-Slaved Camera System

DTIC Science & Technology

2003-02-01

YPR-765 under armour (Report TM-97-A026). Soesterberg, The Netherlands: TNO Human Factors Research Institute. Van Erp, J.B.F., Padmos, P. & Tenkink, E...Institute. Van Erp, J.B.F., Van den Dobbelsteen, J.J. & Padmos, P. (1998). Improved camera-monitor system for driving YPR-765 under armour (Report TM-98

15 CFR Appendix F to Part 30 - FTR to FTSR Concordance

Code of Federal Regulations, 2014 CFR

2014-01-01

..., aircraft, cargo vans, and other carriers and containers 30.33 Vessels, planes, cargo vans, and other carriers and containers sold foreign. 30.27 Return of exported cargo to the United States prior to reaching... transactions. 30.26 Reporting of vessels, aircraft, cargo vans, and other carriers and containers 30.33 Vessels...

The "Discernment of a Human Face" in Research: A Reaction to Van Hesteren's Human Science and Counselling.

ERIC Educational Resources Information Center

Knowles, Don

1986-01-01

Responds to Van Hesteren's advocacy of a "human science" orientation, using constructs and analytical methods from phenomenology to enhance methodology. Approves of a philosophy of science and of a self-perspective. Questions the need for complex terminology, Van Hesteren's definition of what constitutes research, quantification, and…

A Diverging View of Role Modeling in Medical Education

ERIC Educational Resources Information Center

Sandhu, Gurjit; Rich, Jessica V.; Magas, Christopher; Walker, G. Ross

2015-01-01

Research in the area of role modeling has primarily focused on the qualities and attributes of exceptional role models, and less attention has been given to the act of role modeling itself (Elzubeir & Rizk, 2001; Jochemsen-van der Leeuw, van Dijk, van Etten-Jamaludin, & Wieringa-de Waard, 2013; Wright, 1996; Wright, Wong, & Newill,…

Fundacion Bernard van Leer, Boletin Informativo, 1987-1996 (Bernard van Leer Foundation Information Bulletin).

ERIC Educational Resources Information Center

Fundacion Bernard van Leer, Boletin Informativo, 1996

1996-01-01

This document consists of ten annual Spanish Language Bulletins, published during the period 1987-1996. The early bulletins were largely composed of selections originally published in the Bernard van Lear Foundation's English-Language "Newsletter The articles discuss topics such as: (1) parents as children's first teachers; (2) health and…

Early Childhood Matters: The Bulletin of the Bernard van Leer Foundation, 1999.

ERIC Educational Resources Information Center

Smale, Jim, Ed.

1999-01-01

This document consists of the three 1999 issues of The Bernard van Leer Foundation's "Early Childhood Matters." This periodical, addressed to practitioners in the field of early childhood education, evolved from an in-house publication directed to projects funded by the Bernard van Leer Foundation. Articles in the February 1999 edition…

Early Childhood Matters: The Bulletin of the Bernard van Leer Foundation, 1998.

ERIC Educational Resources Information Center

Smale, Jim, Ed.

1998-01-01

This document consists of the three 1998 issues of The Bernard van Leer Foundations'"Early Childhood Matters." This periodical, addressed to practitioners in the field of early childhood development, evolved from an in-house publication directed to projects funded by the Bernard van Leer Foundation. Articles in the February 1998 edition…