Population-based incidence, treatment and survival of patients with peritoneal metastases of unknown origin.

PubMed

Thomassen, Irene; Verhoeven, Rob H A; van Gestel, Yvette R B M; van de Wouw, Agnes J; Lemmens, Valery E P P; de Hingh, Ignace H J T

2014-01-01

Until recently, peritoneal metastases (PM) were regarded as an untreatable condition, regardless of the organ of origin. Currently, promising treatment options are available for selected patients with PM from colorectal, appendiceal, ovarian or gastric carcinoma. The aim of this study was to investigate the incidence, treatment and survival of patients presenting with PM in whom the origin of PM remains unknown. Data from patients diagnosed with PM of unknown origin during 1984-2010 were extracted from the Eindhoven Cancer Registry. European age-standardised incidence rates were calculated and data on treatment and survival were analysed. In total 1051 patients were diagnosed with PM of unknown origin. In 606 patients (58%) the peritoneum was the only site of metastasis, and 445 patients also had other metastases. Chemotherapy usage has increased from 8% in the earliest period to 16% in most recent years (p=.016). Median survival was extremely poor with only 42days (95% confidence interval (CI) 39-47days) and did not change over time. Median survival of patients not receiving chemotherapy was significantly worse than of those receiving chemotherapy (36 versus 218days, p<.0001). The prognosis of PM of unknown origin is extremely poor and did not improve over time. Given the recent progress that has been achieved in selected patients presenting with PM, maximum efforts should be undertaken in order to diagnose the origin of PM as accurately as possible. Potentially effective treatment strategies should be further explored for patients in whom the organ of origin remains unknown. Copyright © 2013 Elsevier Ltd. All rights reserved.

μ-SRXRF characterization of Brazilian emeralds

NASA Astrophysics Data System (ADS)

Curado, J. F.; Radtke, M.; Buzanich, G.; Reinholz, U.; Riesemeier, H.; Guttler, R. A. S.; Rizzutto, M. A.

2014-04-01

The aim of the present study is to characterize emeralds from different mines of Brazil by using Synchrotron Radiation X-ray Fluorescence Microanalysis (μ-SRXRF). The advantage of this technique is that we can analyze a homogeneous, inclusion free area of the stone with the microbeam to distinguish the elemental fingerprint according to the provenance of the emerald. A total of 47 samples belonging to 5 different Brazilian mines were studied in this work and 28 elements were identified. By means of Principal Component Analysis (PCA) it is possible to build different groups according to the provenance of the stones, which allows to assign samples of unknown origin to the according mine.

[Asperger syndrome associated with macrosomia and sexual identity disorder].

PubMed

Fleta Zaragozano, J; Zapata Usábel, M; López Moreno, María J; Olivares López, J L

2005-10-01

Asperger Syndrome is a pervasive developmental disorder of unknown origin, characterized by pedantic language, lack of reciprocity in social interactions, unusual interests, motor clumsiness and normal or above average intelligence quotient, among other symptoms. Since 1994 it has been defined as a specific entity. We describe the case of a boy with this syndrome, with elevated body weight and height and sexual identity disorder. These alterations have not previously been described in the scientific literature on Asperger syndrome.

Metastatic Neuroendocrine Carcinoma of Unknown Origin Arising in the Femoral Nerve Sheath.

PubMed

Candy, Nicholas; Young, Adam; Allinson, Kieren; Carr, Oliver; McMillen, Jason; Trivedi, Rikin

2017-08-01

Metastatic neuroendocrine carcinoma of unknown origin is a rare condition, usually presenting with lesions in the liver and/or lung. We present the first reported case of a metastatic neuroendocrine carcinoma of unknown origin arising in the femoral nerve sheath. Magnetic resonance imaging demonstrated what was thought to be a schwannoma in the left femoral nerve sheath in the proximal femoral triangle, immediately inferior to the anterior inferior iliac spine. At the time of operation, the tumor capsule was invading surrounding tissue, as well as three trunks of the femoral nerve. The patient underwent a subtotal resection, preserving the integrity of the residual functioning femoral nerve trunks. Histologic evaluation determined that the tumor had features consistent with a metastatic neuroendocrine carcinoma of unknown primary origin. The patient recovered well postoperatively, and subsequent radiologic evaluation failed to demonstrate a potential primary site. Unfortunately, the patient re-presented with disease progression and was subsequently referred to palliative care. We recommend that there is a definite role for surgery in the management of solitary neuroendocrine carcinoma of unknown origin. Copyright © 2017 Elsevier Inc. All rights reserved.

7. Photographic copy of photograph (date unknown, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photographic copy of photograph (date unknown, original print in the possession of the Wisconsin Veterans Museums). LAKE IN FOREGROUND, COTTAGES IN BACK. - Wisconsin Home for Veterans, King, Waupaca County, WI

Ulnar-Sided Wrist Pain due to Long Ulnar Styloid: A Case Report

PubMed Central

Ahsan, Zahab S.; Rivlin, Michael; Jupiter, Jesse B.

2016-01-01

Ulnar styloid impaction syndrome involves repetitive friction between an excessively long ulnar styloid and the carpus, resulting in chondromalacia, synovitis, and pain. The arthroscopic diagnosis, evaluation, and management of this syndrome are not well characterized. We present a patient with chronic wrist pain of unknown origin, culminating with arthroscopic findings demonstrating substantial loss of articular cartilage on both the lunate and triquetrum. The patient successfully underwent operative ulnar styloid excision, ultimately resolving chronic wrist pain symptomology. PMID:27777823

Segmental Vitiligo.

PubMed

van Geel, Nanja; Speeckaert, Reinhart

2017-04-01

Segmental vitiligo is characterized by its early onset, rapid stabilization, and unilateral distribution. Recent evidence suggests that segmental and nonsegmental vitiligo could represent variants of the same disease spectrum. Observational studies with respect to its distribution pattern point to a possible role of cutaneous mosaicism, whereas the original stated dermatomal distribution seems to be a misnomer. Although the exact pathogenic mechanism behind the melanocyte destruction is still unknown, increasing evidence has been published on the autoimmune/inflammatory theory of segmental vitiligo. Copyright © 2016 Elsevier Inc. All rights reserved.

15. Photocopy of photograph (original in WACC), photographer unknown, c. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of photograph (original in WACC), photographer unknown, c. 1917 BEN ERICKSON IN WWI UNIFORM STANDING IN FRONT OF SOUTH LIVING ROOM WINDOW (ADOBE WALLS) - Faraway Ranch, Willcox, Cochise County, AZ

3. Photocopy of photograph (location of original unknown) Mary Mather, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of photograph (location of original unknown) Mary Mather, photographer, ca. 1920 PARTIAL EAST ELEVATION, OBSCURED BY FOLIAGE - Bagatelle Plantation, East River Road (moved to Iberville Parish), Donaldsonville, Ascension Parish, LA

Bayesian methods for characterizing unknown parameters of material models

DOE PAGES

Emery, J. M.; Grigoriu, M. D.; Field Jr., R. V.

2016-02-04

A Bayesian framework is developed for characterizing the unknown parameters of probabilistic models for material properties. In this framework, the unknown parameters are viewed as random and described by their posterior distributions obtained from prior information and measurements of quantities of interest that are observable and depend on the unknown parameters. The proposed Bayesian method is applied to characterize an unknown spatial correlation of the conductivity field in the definition of a stochastic transport equation and to solve this equation by Monte Carlo simulation and stochastic reduced order models (SROMs). As a result, the Bayesian method is also employed tomore » characterize unknown parameters of material properties for laser welds from measurements of peak forces sustained by these welds.« less

Bayesian methods for characterizing unknown parameters of material models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Emery, J. M.; Grigoriu, M. D.; Field Jr., R. V.

A Bayesian framework is developed for characterizing the unknown parameters of probabilistic models for material properties. In this framework, the unknown parameters are viewed as random and described by their posterior distributions obtained from prior information and measurements of quantities of interest that are observable and depend on the unknown parameters. The proposed Bayesian method is applied to characterize an unknown spatial correlation of the conductivity field in the definition of a stochastic transport equation and to solve this equation by Monte Carlo simulation and stochastic reduced order models (SROMs). As a result, the Bayesian method is also employed tomore » characterize unknown parameters of material properties for laser welds from measurements of peak forces sustained by these welds.« less

1. Photocopy of photograph (original print located in Pope & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of photograph (original print located in Pope & Talbot Archives. Port Gamble, WA.) Unknown Photographer, Unknown Date. View of Walker-Ames House, house no. 1, facing southwest. - Walker-Ames House, Rainier Avenue, Port Gamble, Kitsap County, WA

43. Photocopy of photograph, photographer unknown, ca January 1929 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photocopy of photograph, photographer unknown, ca January 1929 (original print located at Arizona Department of Transportation, Phoenix AZ). COMPLETED BRIDGE. - Navajo Bridge, Spanning Colorado River at U.S. Highway 89 Alternate, Page, Coconino County, AZ

13. Photocopy of photograph (original print at Riveside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph (original print at Riveside Library, Local History Collection), photographer and date unknown. VIEW OF JAPANESE WORKER HOUSING, ARLINGTON HEIGHTS FRUIT COMPANY, EXACT LOCATION UNKNOWN - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

9. Photocopy of drawing (Original in possession of National Archives ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of drawing (Original in possession of National Archives and Record Service, Record Group 92) Delineator unknown, Date unknown FIRST FLOOR PLAN - Omaha Quartermaster Depot Historic District, Twenty-second & Woolworth Streets, Omaha, Douglas County, NE

8. Photocopy of drawing (Original in possession of National Archives ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of drawing (Original in possession of National Archives and Record Service, Record Group 92) Delineator unknown, Date unknown BASEMENT FLOOR PLAN - Omaha Quartermaster Depot Historic District, Twenty-second & Woolworth Streets, Omaha, Douglas County, NE

10. Photocopy of drawing (Original in possession of National Archives ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of drawing (Original in possession of National Archives and Record Service, Record Group 92) Delineator unknown, Date unknown SECOND FLOOR PLAN - Omaha Quartermaster Depot Historic District, Twenty-second & Woolworth Streets, Omaha, Douglas County, NE

6. Photographic copy of photograph (date unknown, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photographic copy of photograph (date unknown, original print in the possession of the Wisconsin Veterans Museums). COTTAGES, INCLUDING 'J.P. McPHERSON POST NO. 27 CAFE GENEVA'. - Wisconsin Home for Veterans, King, Waupaca County, WI

A Novel In-Beam Delayed Neutron Counting Technique for Characterization of Special Nuclear Materials

NASA Astrophysics Data System (ADS)

Bentoumi, G.; Rogge, R. B.; Andrews, M. T.; Corcoran, E. C.; Dimayuga, I.; Kelly, D. G.; Li, L.; Sur, B.

2016-12-01

A delayed neutron counting (DNC) system, where the sample to be analyzed remains stationary in a thermal neutron beam outside of the reactor, has been developed at the National Research Universal (NRU) reactor of the Canadian Nuclear Laboratories (CNL) at Chalk River. The new in-beam DNC is a novel approach for non-destructive characterization of special nuclear materials (SNM) that could enable identification and quantification of fissile isotopes within a large and shielded sample. Despite the orders of magnitude reduction in neutron flux, the in-beam DNC method can be as informative as the conventional in-core DNC for most cases while offering practical advantages and mitigated risk when dealing with large radioactive samples of unknown origin. This paper addresses (1) the qualification of in-beam DNC using a monochromatic thermal neutron beam in conjunction with a proven counting apparatus designed originally for in-core DNC, and (2) application of in-beam DNC to an examination of large sealed capsules containing unknown radioactive materials. Initial results showed that the in-beam DNC setup permits non-destructive analysis of bulky and gamma shielded samples. The method does not lend itself to trace analysis, and at best could only reveal the presence of a few milligrams of 235U via the assay of in-beam DNC total counts. Through analysis of DNC count rates, the technique could be used in combination with other neutron or gamma techniques to quantify isotopes present within samples.

Unusual presentation of anaplastic large cell lymphoma with clinical course mimicking fever of unknown origin and sepsis: autopsy study of five cases.

PubMed

Mosunjac, Marina B; Sundstrom, J Bruce; Mosunjac, Mario I

2008-10-01

To describe a subset of cases with the unusual clinical and histomorphological presentation of anaplastic large cell lymphoma (ALCL) mimicking fever of unknown origin (FUO) and sepsis. A pathology database was searched using full term Systematized Nomenclature of Medicine codes for ALCL to identify 23ALCL cases from the period 1999-2006. Of those, five cases that did not have a correct premortem diagnosis were further analyzed to elucidate the reasons for delayed and incorrect pre-mortem diagnosis. The analyzed data included clinical presentation, duration of symptoms, duration of hospital stay, premortem presumed cause of death, white blood cell count, platelet count, anion gap and blood pH, liver enzymes (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase), lactate, coagulation tests (prothrombin time, partial thromboplastin time, fibrinogen, D-dimers), microbiology cultures, and radiology and surgical pathology reports. Autopsy reports were reviewed for description of major gross findings, initial clinical diagnosis, and cause of death. Five fatal and pre-mortem unrecognized ALCL cases were characterized by rapid decline, with histologic findings showing predominantly extranodal involvement, intravascular lymphomatosis, and hemophagocytosis. The cases were also characterized by unusual clinical manifestations including a FUO, sepsis, and disseminated intravascular coagulation-like picture, lactic acidosis, hepatosplenomegaly, and absence of significant peripheral adenopathy. There is a distinct group of ALCLs with unique and specific clinical, gross autopsy, and histopathologic findings. Recognition of this clinical variant may facilitate early detection and potentially timely diagnosis and therapy.

Rapid direct analysis to discriminate geographic origin of extra virgin olive oils by flash gas chromatography electronic nose and chemometrics.

PubMed

Melucci, Dora; Bendini, Alessandra; Tesini, Federica; Barbieri, Sara; Zappi, Alessandro; Vichi, Stefania; Conte, Lanfranco; Gallina Toschi, Tullia

2016-08-01

At present, the geographical origin of extra virgin olive oils can be ensured by documented traceability, although chemical analysis may add information that is useful for possible confirmation. This preliminary study investigated the effectiveness of flash gas chromatography electronic nose and multivariate data analysis to perform rapid screening of commercial extra virgin olive oils characterized by a different geographical origin declared in the label. A comparison with solid phase micro extraction coupled to gas chromatography mass spectrometry was also performed. The new method is suitable to verify the geographic origin of extra virgin olive oils based on principal components analysis and discriminant analysis applied to the volatile profile of the headspace as a fingerprint. The selected variables were suitable in discriminating between "100% Italian" and "non-100% Italian" oils. Partial least squares discriminant analysis also allowed prediction of the degree of membership of unknown samples to the classes examined. Copyright © 2016. Published by Elsevier Ltd.

15. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF BARNS, STABLE AND FIELD EQUIPMENT, ARLINGTON HEIGHTS FRUIT COMPANY, EXACT LOCATION UNKNOWN - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

2. Photocopy of photograph (location of original unknown) Mary Mather, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of photograph (location of original unknown) Mary Mather, photographer, ca. 1920 GENERAL VIEW OF WEST (LEFT) AND SOUTH (RIGHT) FACADES, TAKEN FROM LEVEE - Bagatelle Plantation, East River Road (moved to Iberville Parish), Donaldsonville, Ascension Parish, LA

47. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Photocopy of a photograph (original print in the collection of the Claremont Historical Society) photographer unknown, no date INTERIOR OF OFFICE AND EMPLOYEES IN AN UNKNOWN BUILDING - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

Protracted fever of unknown origin as the presenting symptom of Behçet's disease. Report of a case.

PubMed

Niamane, Radouane; Karim Moudden, Mohamed; Zyani, Mahamed; Hda, Ali

2005-03-01

We report a case of Behçet's disease that presented as protracted fever of unknown origin. The diagnosis was established when a thromboembolic event and ora3l aphthous ulcers occurred simultaneously. Antibiotics had no effect on the fever, which resolved when glucocorticoid and anticoagulant therapy was given. Among causes of protracted fever of unknown origin, Behçet's disease is exceedingly rare but should be considered together with the other vasculitides. Above all, the presence of a fever should prompt a search for a thromboembolic complication.

The Extraterrestrial Materials Simulation Laboratory

NASA Technical Reports Server (NTRS)

Green, J. R.

2001-01-01

In contrast to fly-by and orbital missions, in situ missions face an incredible array of challenges in near-target navigation, landing site selection, descent, landing, science operations, sample collection and handling, drilling, anchoring, subsurface descent, communications, and contamination. The wide range of materials characteristics and environments threaten mission safety and success. For example, many physical properties are poorly characterized, including strength, composition, heterogeneity, phase change, texture, thermal properties, terrain features, atmospheric interaction, and stratigraphy. Examples of the range of materials properties include, for example: (1) Comets, with a possible compressive strength ranging from a light fluff to harder than concrete: 10(exp 2) to 10 (exp 8) Pa; (2) Europa, including a possible phase change at the surface, unknown strength and terrain roughness; and (3) Titan, with a completely unknown surface and possible liquid ocean. Additional information is contained in the original extended abstract.

42. Photocopy of photograph, photographer unknown, 12 September 1928 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Photocopy of photograph, photographer unknown, 12 September 1928 (original print located at Arizona Department of Transportation, Phoenix AZ). BRIDGE IMMEDIATELY AFTER INSERTION OF CENTER PIN. - Navajo Bridge, Spanning Colorado River at U.S. Highway 89 Alternate, Page, Coconino County, AZ

44. Photocopy of photograph, photographer unknown, 1415 June 1929 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Photocopy of photograph, photographer unknown, 14-15 June 1929 (original print located at Utah State Historical Society Photograph Collection, Salt Lake City UT). DEDICATION CEREMONY AT BRIDGE. - Navajo Bridge, Spanning Colorado River at U.S. Highway 89 Alternate, Page, Coconino County, AZ

Photographic copy of photograph, photographer unknown, 1942 (original print located ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, 1942 (original print located at Southern UTE Agency, Bureau of Indian Affairs Office, Ignacio, Colorado). West front and south side of boy's dormitory. - Southern Ute Boarding School, Boy's Dormitory, Ouray & Capote Drives, Ignacio, La Plata County, CO

Photographic copy of photograph, photographer unknown, 1942 (original print located ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, 1942 (original print located at Southern UTE Agency, Bureau of Indian Affairs Office, Ignacio, Colorado). East rear and north side of boy's dormitory. - Southern Ute Boarding School, Boy's Dormitory, Ouray & Capote Drives, Ignacio, La Plata County, CO

45. Photocopy of photograph, photographer unknown, 1415 June 1929 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Photocopy of photograph, photographer unknown, 14-15 June 1929 (original print located at Arizona Department of Transportation, Phoenix AZ). AIRPLANE STUNT DURING DEDICATION CEREMONY AT BRIDGE. - Navajo Bridge, Spanning Colorado River at U.S. Highway 89 Alternate, Page, Coconino County, AZ

14. Photocopy of historic photograph (original photograph on file at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of historic photograph (original photograph on file at Fairchild Air Force Museum, Spokane, WA) Photographer unknown, date unknown BOMBER ALERT FACILITY, INTERIOR, SLEEPING QUARTERS - Fairchild Air Force Base, Bomber Alert Facility, 803G South Taxi Way, Spokane, Spokane County, WA

Cheilitis granulomatosa associated with allergic contact dermatitis to betel quid.

PubMed

Chiu, Cheng-Sheng; Tsai, Yi-Lun

2008-04-01

Cheilitis granulomatosa (CG) is a rare disorder of unknown origin, which is characterized clinically by painless, recurrent or persistent swelling of 1 or both lips. Betel quids, composed of betel nuts (seeds of the Areca catechu), slake lime, and Piper betel leaf/or Piper betel inflorescence, are widely used in Asia and strongly associated with oral mucosal disease. It has also been found to be a cause of contact leukomelanosis because of its ingredients of various chemicals. We describe a case of CG induced by betel quid chewing.

An Efficient Implementation of the GMC Micromechanics Model for Multi-Phased Materials with Complex Microstructures

NASA Technical Reports Server (NTRS)

Pindera, Marek-Jerzy; Bednarcyk, Brett A.

1997-01-01

An efficient implementation of the generalized method of cells micromechanics model is presented that allows analysis of periodic unidirectional composites characterized by repeating unit cells containing thousands of subcells. The original formulation, given in terms of Hill's strain concentration matrices that relate average subcell strains to the macroscopic strains, is reformulated in terms of the interfacial subcell tractions as the basic unknowns. This is accomplished by expressing the displacement continuity equations in terms of the stresses and then imposing the traction continuity conditions directly. The result is a mixed formulation wherein the unknown interfacial subcell traction components are related to the macroscopic strain components. Because the stress field throughout the repeating unit cell is piece-wise uniform, the imposition of traction continuity conditions directly in the displacement continuity equations, expressed in terms of stresses, substantially reduces the number of unknown subcell traction (and stress) components, and thus the size of the system of equations that must be solved. Further reduction in the size of the system of continuity equations is obtained by separating the normal and shear traction equations in those instances where the individual subcells are, at most, orthotropic. The reformulated version facilitates detailed analysis of the impact of the fiber cross-section geometry and arrangement on the response of multi-phased unidirectional composites with and without evolving damage. Comparison of execution times obtained with the original and reformulated versions of the generalized method of cells demonstrates the new version's efficiency.

Photographic copy of photograph, photographer unknown, August 1912 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, August 1912 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "A VIEW OF METHOD OF DAM CONSTRUCTION" - Kachess Dam, Kachess River, 1.5 miles north of Interstate 90, Easton, Kittitas County, WA

Photographic copy of photograph, photographer unknown, ca. 1930 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, ca. 1930 (original print located at Colorado Historical Society, Denver, Colorado). Overall view of Southern UTE Agency Boarding School, with boys dormitory at center. - Southern Ute Boarding School, Boy's Dormitory, Ouray & Capote Drives, Ignacio, La Plata County, CO

Novel duck parvovirus identified in Cherry Valley ducks (Anas platyrhynchos domesticus), China.

PubMed

Li, Chuanfeng; Li, Qi; Chen, Zongyan; Liu, Guangqing

2016-10-01

An unknown infectious disease in Cherry Valley ducks (Anas platyrhynchos domesticus) characterized by short beak and strong growth retardation occurred in China during 2015. The causative agent of this disease, tentatively named duck short beak and dwarfism syndrome (DSBDS), as well as the evolutionary relationships between this causative agent and all currently known avian-origin parvoviruses were clarified by virus isolation, transmission electron microscope (TEM) observation, analysis of nuclear acid type, (RT-)PCR identification, whole genome sequencing, and NS1 protein sequences-based phylogenetic analyses. The results indicated that the causative agent of DSBDS is closely related with the goose parvovirus-like virus, which is divergent from all currently known avian-origin parvoviruses and should be a novel duck parvovirus (NDPV). Copyright © 2016 Elsevier B.V. All rights reserved.

How stock of origin affects performance of individuals across a meta-ecosystem: an example from sockeye salmon.

PubMed

Griffiths, Jennifer R; Schindler, Daniel E; Seeb, Lisa W

2013-01-01

Connectivity among diverse habitats can buffer populations from adverse environmental conditions, influence the functioning of meta-ecosystems, and ultimately affect the reliability of ecosystem services. This stabilizing effect on populations is proposed to derive from complementarity in growth and survival conditions experienced by individuals in the different habitats that comprise meta-ecosystems. Here we use the fine scale differentiation of salmon populations between diverse lake habitats to assess how rearing habitat and stock of origin affect the body condition of juvenile sockeye salmon. We use genetic markers (single nucleotide polymorphisms) to assign individuals of unknown origin to stock group and in turn characterize ecologically relevant attributes across habitats and stocks. Our analyses show that the body condition of juvenile salmon is related to the productivity of alternative habitats across the watershed, irrespective of their stock of origin. Emigrants and residents with genetic origins in the high productivity lake were also differentiated by their body condition, poor and high respectively. These emigrants represented a substantial proportion of juvenile sockeye salmon rearing in the lower productivity lake habitat. Despite emigrants originating from the more productive lake, they did not differ in body condition from the individuals spawned in the lower productivity, recipient habitat. Genetic tools allowed us to assess the performance of different stocks groups across the diverse habitats comprising their meta-ecosystem. The ability to characterize the ecological consequences of meta-ecosystem connectivity can help develop strategies to protect and restore ecosystems and the services they provide to humans.

How Stock of Origin Affects Performance of Individuals across a Meta-Ecosystem: An Example from Sockeye Salmon

PubMed Central

Griffiths, Jennifer R.; Schindler, Daniel E.; Seeb, Lisa W.

2013-01-01

Connectivity among diverse habitats can buffer populations from adverse environmental conditions, influence the functioning of meta-ecosystems, and ultimately affect the reliability of ecosystem services. This stabilizing effect on populations is proposed to derive from complementarity in growth and survival conditions experienced by individuals in the different habitats that comprise meta-ecosystems. Here we use the fine scale differentiation of salmon populations between diverse lake habitats to assess how rearing habitat and stock of origin affect the body condition of juvenile sockeye salmon. We use genetic markers (single nucleotide polymorphisms) to assign individuals of unknown origin to stock group and in turn characterize ecologically relevant attributes across habitats and stocks. Our analyses show that the body condition of juvenile salmon is related to the productivity of alternative habitats across the watershed, irrespective of their stock of origin. Emigrants and residents with genetic origins in the high productivity lake were also differentiated by their body condition, poor and high respectively. These emigrants represented a substantial proportion of juvenile sockeye salmon rearing in the lower productivity lake habitat. Despite emigrants originating from the more productive lake, they did not differ in body condition from the individuals spawned in the lower productivity, recipient habitat. Genetic tools allowed us to assess the performance of different stocks groups across the diverse habitats comprising their meta-ecosystem. The ability to characterize the ecological consequences of meta-ecosystem connectivity can help develop strategies to protect and restore ecosystems and the services they provide to humans. PMID:23505539

Photographic copy of photograph, photographer unknown, August 1912 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, August 1912 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "METHOD OF CONSTRUCTING DAM AFTER REMOVING OF TRESTLE" - Kachess Dam, Kachess River, 1.5 miles north of Interstate 90, Easton, Kittitas County, WA

Photographic copy of photograph, photographer unknown, ca. 1930 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, ca. 1930 (original print located at Colorado Historical Society, Denver, Colorado). Overall views of Southern Ute Agency Boarding School, with boys' dormitory at left of lower view. - Southern Ute Boarding School, Boy's Dormitory, Ouray & Capote Drives, Ignacio, La Plata County, CO

Photographic copy of photograph, date unknown (original print located at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, date unknown (original print located at the History Office, U.S. Army South, Fort Clayton, Republic of Panama). Early view of Fort Sherman from boat dock with theater in background, facing southwest. - Fort Sherman, Toro Point on Limon Bay, Colon, Former Panama Canal Zone, CZ

Clinical pictures of unknown origin in neurology: past, present and future usefulness of artificial intelligence.

PubMed

Conti, Andrea A; Conti, Antonio; Masoni, Marco; Gensini, Gian Franco

2005-01-01

Although, in the course of the last 50 years, the achievements in the medical field have been astonishing, at the beginning of the third millennium a number of clinical pictures are still left without a precise nosographic origin. In the past, the delay in scientific communication was the main explanation presented for the lack of understanding of clinical pictures of unknown nosographic origin. The history of medicine provides excellent examples of this dispersion of human capital, even if the history of clinical neurology presents "exceptions" (the pictures that we now call de la Tourette's syndrome and Parkinson's disease) that indicate that major clinical syndromes could be clearly detected and relatively rapidly diffused even in the 19th century. Contrary to the past, the delay in scientific communication no longer seems an obstacle to the sharing of medical knowledge. Nevertheless, the problem of the in-depth comprehension of clinical pictures of unknown nosographic origin still remains dominant, mainly because of the limited spread of ample and flexible online accessible databases of unknown nosographic origin clinical syndromes. The need for interactive electronic archives and other artificial intelligence resources in order to promote progress in clinical knowledge is discussed in this paper.

Systematic discovery of antiphage defense systems in the microbial pangenome.

PubMed

Doron, Shany; Melamed, Sarah; Ofir, Gal; Leavitt, Azita; Lopatina, Anna; Keren, Mai; Amitai, Gil; Sorek, Rotem

2018-03-02

The arms race between bacteria and phages led to the development of sophisticated antiphage defense systems, including CRISPR-Cas and restriction-modification systems. Evidence suggests that known and unknown defense systems are located in "defense islands" in microbial genomes. Here, we comprehensively characterized the bacterial defensive arsenal by examining gene families that are clustered next to known defense genes in prokaryotic genomes. Candidate defense systems were systematically engineered and validated in model bacteria for their antiphage activities. We report nine previously unknown antiphage systems and one antiplasmid system that are widespread in microbes and strongly protect against foreign invaders. These include systems that adopted components of the bacterial flagella and condensin complexes. Our data also suggest a common, ancient ancestry of innate immunity components shared between animals, plants, and bacteria. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

[Focal myositis: An unknown disease].

PubMed

Gallay, L; Streichenberger, N; Benveniste, O; Allenbach, Y

2017-10-01

Focal myositis are inflammatory muscle diseases of unknown origin. At the opposite from the other idiopathic inflammatory myopathies, they are restricted to a single muscle or to a muscle group. They are not associated with extramuscular manifestations, and they have a good prognosis without any treatment. They are characterized by a localized swelling affecting mostly lower limbs. The pseudo-tumor can be painful, but is not associated with a muscle weakness. Creatine kinase level is normal. Muscle MRI shows an inflammation restricted to a muscle or a muscle group. Muscle biopsy and pathological analysis remain necessary for the diagnosis, showing inflammatory infiltrates composed by macrophages and lymphocytes without any specific distribution within the muscle. Focal overexpression of HLA-1 by the muscle fibers is frequently observed. The muscle biopsy permits to rule out differential diagnosis such a malignancy (sarcoma). Spontaneous remission occurs within weeks or months after the first symptoms, relapse is unusual. Copyright © 2017. Published by Elsevier SAS.

Pneumocandin biosynthesis: involvement of a trans-selective proline hydroxylase.

PubMed

Houwaart, Stefanie; Youssar, Loubna; Hüttel, Wolfgang

2014-11-03

Echinocandins are cyclic nonribosomal hexapeptides based mostly on nonproteinogenic amino acids and displaying strong antifungal activity. Despite previous studies on their biosynthesis by fungi, the origin of three amino acids, trans-4- and trans-3-hydroxyproline, as well as trans-3-hydroxy-4-methylproline, is still unknown. Here we describe the identification, overexpression, and characterization of GloF, the first eukaryotic α-ketoglutarate/Fe(II) -dependent proline hydroxylase from the pneumocandin biosynthesis cluster of the fungus Glarea lozoyensis ATCC 74030. In in vitro transformations with L-proline, GloF generates trans-4- and trans-3-hydroxyproline simultaneously in a ratio of 8:1; the latter reaction was previously unknown for proline hydroxylase catalysis. trans-4-Methyl-L-proline is converted into the corresponding trans-3-hydroxyproline. All three hydroxyprolines required for the biosynthesis of the echinocandins pneumocandins A0 and B0 in G. lozoyensis are thus provided by GloF. Sequence analyses revealed that GloF is not related to bacterial proline hydroxylases, and none of the putative proteins with high sequence similarity in the databases has been characterized so far. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Photographic copy of photograph, photographer unknown, ca. 1915 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, ca. 1915 (original print located at Southern Ute Agency, Bureau of Indian Affairs Office, Ignacio, Colorado). Overall view of Southern Ute Agency Boarding School, with main building (boy's dormitory) at right. - Southern Ute Boarding School, Boy's Dormitory, Ouray & Capote Drives, Ignacio, La Plata County, CO

Magnetic Resonance Characterization of Defects in Icosahedral and Cubic Boron Arsenide Bulk Crystals

NASA Astrophysics Data System (ADS)

Glaser, E. R.; Freitas, J. A., Jr.; Cress, C. D.; Perkins, F. K.; Prokes, S. M.; Ruppalt, L. B.; Culbertson, J. C.; Whiteley, C.; Edgar, J. H.; Tian, F.; Ren, Z.; Kim, J.; Shi, L.; Naval Research Lab Team; Kansas State U. Team; U. Houston Team; U. Texas Team

Low-temperature electron spin resonance (ESR) at 9.5 GHz and optically-detected magnetic resonance (ODMR) at 24 GHz were employed to investigate point defects in icosahedral and cubic Boron Arsenide bulk crystals. These semiconductors are of interest for use in high radiation and/or high temperature environments. ESR of the (001) B12As2 (Eg = 3.47 eV) mm-size platelets revealed two distinct features of unknown origin. The first signal is characterized by Zeeman splitting g-values of g|| = 2.017, g⊥ = 2.0183 while the second with g|| = 2.0182, g⊥ = 1.9997. Most notably, the second signal was also observed from ODMR on the broad 2.4 eV ``yellow/green'' photoluminescence band previously reported for these crystals and suggests its direct involvement in this likely defect-related radiative recombination process. Preliminary ESR obtained for the 100-300 micron-size cubic BAs crystals revealed a signal with g-value of 2.018 (very similar to that found for the B12As2 crystals) and broad FWHM value of 182 G. Possible origins of these defects will be discussed.

An Evidence-Based Review Literature About Risk Indicators and Management of Unknown-Origin Xerostomia

PubMed Central

Agha-Hosseini, Farzaneh; Moosavi, Mahdieh-Sadat

2013-01-01

This evidence-based article reviews risk indicators and management of unknown-origin xerostomia. Xerostomia and hyposalivation refer to different aspects of dry mouth. Xerostomia is a subjective sensation of dry mouth, whilst hyposalivation is defined as an objective assessment of reduced salivary flow rate. About 30% of the elderly (65 years and older) experience xerostomia and hyposalivation. Structural and functional factors, or both may lead to salivary gland dysfunction. The EBM literature search was conducted by using the medical literature database MEDLINE via PubMed and OvidMedline search engines. Results were limited to English language articles (1965 to present) including clinical trials (CT), randomized controlled trials (RCT), systematic reviews and review articles. Case control or cohort studies were included for the etiology. Neuropathic etiology such as localized oral alteration of thermal sensations, saliva composition change (for example higher levels of K, Cl, Ca, IgA, amylase, calcium, PTH and cortisol), lower levels of estrogen and progesterone, smaller salivary gland size, and illnesses such as lichen planus, are risk indicators for unknown-origin xerostomia. The management is palliative and preventative. Management of symptoms includes drug administration (systemic secretogogues, saliva substitutes and bile secretion-stimulator), night guard, diet and habit modifications. Other managements may be indicated to treat adverse effects. Neuropathic etiology, saliva composition change, smaller salivary gland size, and illnesses such as oral lichen planus can be suggestive causes for unknown-origin xerostomia. However, longitudinal studies will be important to elucidate the causes of unknown-origin xerostomia. PMID:25512755

Mapping copy number variation by population-scale genome sequencing.

PubMed

Mills, Ryan E; Walter, Klaudia; Stewart, Chip; Handsaker, Robert E; Chen, Ken; Alkan, Can; Abyzov, Alexej; Yoon, Seungtai Chris; Ye, Kai; Cheetham, R Keira; Chinwalla, Asif; Conrad, Donald F; Fu, Yutao; Grubert, Fabian; Hajirasouliha, Iman; Hormozdiari, Fereydoun; Iakoucheva, Lilia M; Iqbal, Zamin; Kang, Shuli; Kidd, Jeffrey M; Konkel, Miriam K; Korn, Joshua; Khurana, Ekta; Kural, Deniz; Lam, Hugo Y K; Leng, Jing; Li, Ruiqiang; Li, Yingrui; Lin, Chang-Yun; Luo, Ruibang; Mu, Xinmeng Jasmine; Nemesh, James; Peckham, Heather E; Rausch, Tobias; Scally, Aylwyn; Shi, Xinghua; Stromberg, Michael P; Stütz, Adrian M; Urban, Alexander Eckehart; Walker, Jerilyn A; Wu, Jiantao; Zhang, Yujun; Zhang, Zhengdong D; Batzer, Mark A; Ding, Li; Marth, Gabor T; McVean, Gil; Sebat, Jonathan; Snyder, Michael; Wang, Jun; Ye, Kenny; Eichler, Evan E; Gerstein, Mark B; Hurles, Matthew E; Lee, Charles; McCarroll, Steven A; Korbel, Jan O

2011-02-03

Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution architecture of most SVs remains unknown. We constructed a map of unbalanced SVs (that is, copy number variants) based on whole genome DNA sequencing data from 185 human genomes, integrating evidence from complementary SV discovery approaches with extensive experimental validations. Our map encompassed 22,025 deletions and 6,000 additional SVs, including insertions and tandem duplications. Most SVs (53%) were mapped to nucleotide resolution, which facilitated analysing their origin and functional impact. We examined numerous whole and partial gene deletions with a genotyping approach and observed a depletion of gene disruptions amongst high frequency deletions. Furthermore, we observed differences in the size spectra of SVs originating from distinct formation mechanisms, and constructed a map of SV hotspots formed by common mechanisms. Our analytical framework and SV map serves as a resource for sequencing-based association studies.

Overview of measles and mumps vaccine: origin, present, and future of vaccine production.

PubMed

Betáková, T; Svetlíková, D; Gocník, M

2013-01-01

Measles and mumps are common viral childhood diseases that can cause serious complications. Vaccination remains the most efficient way to control the spread of these viruses. The manufacturing capability for viral vaccines produced in embryonated hen eggs and conventional/classical cell substrates, such as chicken embryo fibroblast or primary dog kidney cell substrates, is no longer sufficient. This limitation can be overcome by utilizing other recognized cell substrates such as Madin Darby Canine Kidney (MDCK), Chinese Hamster Ovary (CHO), Vero (monkey origin) cells, MRC-5 (human diploid) or as an alternative, introducing new cell substrates of human or avian origin. A very important factor in vaccine production is the safety and immunogenicity of the final vaccine, where the proper choice of cell substrate used for virus propagation is made. All substrates used in vaccine production must be fully characterized to avoid the contamination of hidden unknown pathogens which is difficult to achieve in primary cell substrates.

Burning mouth syndrome

PubMed Central

Jimson, Sudha; Rajesh, E.; Krupaa, R. Jayasri; Kasthuri, M.

2015-01-01

Burning mouth syndrome (BMS) is a complex disorder that is characterized by warm or burning sensation in the oral mucosa without changes on physical examination. It occurs more commonly in middle-aged and elderly women and often affects the tip of the tongue, lateral borders, lips, hard and soft palate. This condition is probably of multi-factorial origin, often idiopathic, and its etiopathogensis is unknown. BMS can be classified into two clinical forms namely primary and secondary BMS. As a result, a multidisciplinary approach is required for better control of the symptoms. In addition, psychotherapy and behavioral feedback may also help eliminate the BMS symptoms. PMID:26015707

Method of multiplexed analysis using ion mobility spectrometer

DOEpatents

Belov, Mikhail E [Richland, WA; Smith, Richard D [Richland, WA

2009-06-02

A method for analyzing analytes from a sample introduced into a Spectrometer by generating a pseudo random sequence of a modulation bins, organizing each modulation bin as a series of submodulation bins, thereby forming an extended pseudo random sequence of submodulation bins, releasing the analytes in a series of analyte packets into a Spectrometer, thereby generating an unknown original ion signal vector, detecting the analytes at a detector, and characterizing the sample using the plurality of analyte signal subvectors. The method is advantageously applied to an Ion Mobility Spectrometer, and an Ion Mobility Spectrometer interfaced with a Time of Flight Mass Spectrometer.

Photographic copy of photograph, photographer unknown, 18 February 1908 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, photographer unknown, 18 February 1908 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "LAKE KACHESS CRIB DAM. TAKEN FROM UPSTREAM SIDE. 4 FEET OF SNOW" - Kachess Dam, 1904 Cascade Canal Company Crib Dam, Kachess River, 1.5 miles north of Interstate 90, Easton, Kittitas County, WA

28. Photocopy of photograph dated ca. 1940; photographer unknown; original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Photocopy of photograph dated ca. 1940; photographer unknown; original filed as MR2.9/SP8/r373 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; WEST SIDE AFTER SECOND-STORY ADDITION; LOOKING EAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

24. Photographic copy of undated photo; Photographer unknown; Original in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. Photographic copy of undated photo; Photographer unknown; Original in Rath collection at Iowa State University Libraries, Ames, Iowa; Filed under: Rath Packing Company, Printed Photographs, Symbol M, Box 2; REMOVING HIDES ON THE MOVING SKINNING TABLE; LOOKING NORTH - Rath Packing Company, Beef Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Sudden suffocation with cancer of unknown primary: a case report and review of diagnostic approach.

PubMed

Tehrani, Omid S; Ahmad, Omar; Vypritskaya, Ekaterina; Chen, Emily; Hasan, Saba

2012-10-01

A case of a 31-year-old woman with sudden respiratory distress is presented. Preliminary evaluations and imaging studies did not reveal the underlying cause. Workup during hospital stay showed advanced metastatic cancer of unknown primary origin. This is an unusual presentation of cancer of an unknown primary involving the thyroid with sudden suffocation. It suggests that malignancies involving the thyroid gland should be considered in patients with abrupt onset of respiratory distress. Also, this case shows the application of fine needle aspiration in diffuse thyroid enlargements mimicking thyroiditis without nodules. Diagnostic approach to cancer of unknown primary origin (CUP) is reviewed in further detail.

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. View of building 133 being moved; 1933. - Mare Island Naval Shipyard, East of Nave Drive, Vallejo, Solano County, CA

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. View of sawmill after earthquake of 1898. - Mare Island Naval Shipyard, East of Nave Drive, Vallejo, Solano County, CA

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. View of waterfront during World War II; N.D. - Mare Island Naval Shipyard, East of Nave Drive, Vallejo, Solano County, CA

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. Isometric drawing, "early plan for Mare Island", 1870. - Mare Island Naval Shipyard, East of Nave Drive, Vallejo, Solano County, CA

41. Photocopy of progress photograph ca. 1974, photographer unknown. Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Photocopy of progress photograph ca. 1974, photographer unknown. Original photograph Property of United States Air Force, 21" Space Command. This is the source for views 41 to 47. CAPE COD AIR STATION PAVE PAWS FACILITY - SHOWING BUILDING "RED IRON" STEEL STRUCTURE NEARING COMPLETION. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

26. Photocopy of photograph dated 1930; photographer unknown; original filed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. Photocopy of photograph dated 1930; photographer unknown; original filed as MR2.9/SP8/p343 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; THREE-QUARTER VIEW SHOWING WEST SIDE AND SOUTH FRONT SHORTLY AFTER COMPLETION; LOOKING NORTHEAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

27. Photocopy of photograph dated ca. 1940; photographer unknown; original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. Photocopy of photograph dated ca. 1940; photographer unknown; original filed as MR2.9/SP8/r374 in Audio-Visual Collection Minnesota Historical Society, St. Paul; THREE-QUARTER VIEW SHOWING WEST SIDE AND SOUTH FRONT AFTER SECOND-STORY ADDITION; LOOKING NORTHEAST - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

25. Photographic copy of undated photo; Photographer unknown; Original in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. Photographic copy of undated photo; Photographer unknown; Original in Rath collection at Iowa State University Libraries, Ames, Iowa; Filed under: Rath Packing Company, Printed Photographs, Symbol M, Box 2; REMOVING HIDES ON THE SKINNING TABLE; CARCASSES IN HALF-HOIST POSITION; LOOKING SOUTH - Rath Packing Company, Beef Killing Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. View of ammunition depot from across Mare Island Strait; 1961. - Mare Island Naval Shipyard, East of Nave Drive, Vallejo, Solano County, CA

Comparative Metagenomics of Cellulose- and Poplar Hydrolysate-Degrading Microcosms from Gut Microflora of the Canadian Beaver (Castor canadensis) and North American Moose (Alces americanus) after Long-Term Enrichment

PubMed Central

Wong, Mabel T.; Wang, Weijun; Couturier, Marie; Razeq, Fakhria M.; Lombard, Vincent; Lapebie, Pascal; Edwards, Elizabeth A.; Terrapon, Nicolas; Henrissat, Bernard; Master, Emma R.

2017-01-01

To identify carbohydrate-active enzymes (CAZymes) that might be particularly relevant for wood fiber processing, we performed a comparative metagenomic analysis of digestive systems from Canadian beaver (Castor canadensis) and North American moose (Alces americanus) following 3 years of enrichment on either microcrystalline cellulose or poplar hydrolysate. In total, 9,386 genes encoding CAZymes and carbohydrate-binding modules (CBMs) were identified, with up to half predicted to originate from Firmicutes, Bacteroidetes, Chloroflexi, and Proteobacteria phyla, and up to 17% from unknown phyla. Both PCA and hierarchical cluster analysis distinguished the annotated glycoside hydrolase (GH) distributions identified herein, from those previously reported for grass-feeding mammals and herbivorous foragers. The CAZyme profile of moose rumen enrichments also differed from a recently reported moose rumen metagenome, most notably by the absence of GH13-appended dockerins. Consistent with substrate-driven convergence, CAZyme profiles from both poplar hydrolysate-fed cultures differed from cellulose-fed cultures, most notably by increased numbers of unique sequences belonging to families GH3, GH5, GH43, GH53, and CE1. Moreover, pairwise comparisons of moose rumen enrichments further revealed higher counts of GH127 and CE15 families in cultures fed with poplar hydrolysate. To expand our scope to lesser known carbohydrate-active proteins, we identified and compared multi-domain proteins comprising both a CBM and domain of unknown function (DUF) as well as proteins with unknown function within the 416 predicted polysaccharide utilization loci (PULs). Interestingly, DUF362, identified in iron–sulfur proteins, was consistently appended to CBM9; on the other hand, proteins with unknown function from PULs shared little identity unless from identical PULs. Overall, this study sheds new light on the lignocellulose degrading capabilities of microbes originating from digestive systems of mammals known for fiber-rich diets, and highlights the value of enrichment to select new CAZymes from metagenome sequences for future biochemical characterization. PMID:29326667

Infectivity of wild bird-origin avian paramyxovirus serotype 1 and vaccine effectiveness in chickens.

PubMed

Shabbir, Muhammad Zubair; Akhtar, Sameera; Tang, Yi; Yaqub, Tahir; Ahmad, Arfan; Mustafa, Ghulam; Alam, Muhammad Azhar; Santhakumar, Diwakar; Nair, Venugopal; Munir, Muhammad

2016-12-01

Newcastle disease virus, a prototype avian paramyxovirus serotype 1 (APMV-1), causes economically devastating disease in avian species around the world. Newcastle disease is enzootic in Pakistan and recurrent outbreaks are frequent in multiple avian species even after continuous and extensive use of vaccines. A number of APMV-1 and pigeon paramyxovirus serotype 1 (PPMV-1) strains have been isolated and genetically characterized in recent years. However, the impact of recently characterized wild bird-origin APMVs in domestic poultry, and the potency of routinely used vaccines against these novel and genetically diverse viruses remain unknown. Here, we applied next-generation sequencing for unbiased complete genome characterization of APMV-1 and PPMV-1 strains isolated from clinically diseased peacocks (Pavocristatus) and pigeons (Columbalivia), respectively. Global phylodynamics and evolutionary analysis demonstrates Pigeon/MZS-UVAS-Pak/2014 is clustered into lineage 4 (or genotype VI) and Peacock/MZS-UVAS-Pak/2014 into lineage 5 (or genotype VII). The genomes of both isolates encoded for polybasic residues (112RRQKR↓F117) at the fusion protein cleavage motif along with a number of important substitutions in the surface glycoproteins compared with the vaccine strains. Clinicopathological and immunological investigations in domesticated chickens indicate that these isolates can potentially transmit between tested avian species, can cause systemic infections, and can induce antibodies that are unable to prevent virus shedding. Collectively, the data from these genomic and biological assessments highlight the potential of wild birds in transmitting APMVs to domesticated chickens. The study also demonstrates that the current vaccine regimens are incapable of providing complete protection against wild bird-origin APMVs and PPMVs.

29. Photocopy of photograph dated 1930; photographer unknown; original filed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Photocopy of photograph dated 1930; photographer unknown; original filed as HE17/p7 in Audio-Visual Collection of Minnesota Historical Society, St. Paul; HANGAR AREA, INTERIOR, SHOWING LONGITUDINAL 'CARRYING' TRUSS AND CANTILEVERED SECTION OF ROOF TRUSSES; LOOKING NORTHWEST FROM SOUTHEAST FRONT CORNER - Northwest Airways Hangar & Administration Building, 590 Bayfield Street, St. Paul Downtown Airport (Holman), Saint Paul, Ramsey County, MN

8. Photocopy of photograph, date unknown (original print on file ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of photograph, date unknown (original print on file at U.S. Army Intelligence Security Command, Fort Belvoir, Virginia). VIEW OF SULLINS COLLEGE, BRISTOL, VIRGINIA. SULLINS COLLEGE PRESIDENT WILLIAM MARTIN FOUNDED ARLINGTON HALL JUNIOR COLLEGE, AND APPEARS TO HAVE LOOSELY BASED THE DESIGN OF THE NEW SCHOOL'S BUILDINGS UPON THOSE AT SULLINS. - Arlington Hall Station, 4000 Arlington Boulevard, Arlington, Arlington County, VA

Risk Factors for Speech Delay of Unknown Origin in Three-Year-Old Children.

ERIC Educational Resources Information Center

Campbell, Thomas F.; Dollaghan, Christine A.; Rockette, Howard E.; Paradise, Jack L.; Feldman, Heidi M.; Shriberg, Lawrence D.; Sabo, Diane L.; Kurs-Lasky, Marcia

2003-01-01

Compared 100 three-year-olds with speech delay of unknown origin and 539 same-age peers with respect to 6 speech disorder variables; also examined abnormal hearing in a subset of 279 children. Found significant odds ratios only for low maternal education, male sex, and positive family history; a child with all 3 factors was 7.71 times as likely to…

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. Coal sheds with coals; 1906. - Mare Island Naval Shipyard, Coal Sheds, Waterfront Avenue, northwest corner of Waterfront Avenue & Fourth Street, Vallejo, Solano County, CA

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. Building H1; 1920. - Mare Island Naval Shipyard, Hospital Headquarters, Johnson Lane, west side at intersection of Johnson Lane & Cossey Street, Vallejo, Solano County, CA

Analysis of satellite data on energetic particles of ionospheric origin

NASA Technical Reports Server (NTRS)

Sharp, R. D.; Johnson, R. G.; Shelley, E. G.

1975-01-01

The morphology was studied of precipitating O(+) and H(+) ions in the energy range 0.7 equal to or less than E equal to or less than 12 keV during the storm-time period from December 16-18, 1971, which encompassed two principal magnetic storms. The results are described with emphasis on the temporal variations of parameters characterizing the intensity, average energy, and spatial location of the zones of precipitation of the two ionic species. One of the principal results was the finding that the intensity of the precipitating O(+) ions was well correlated with the geomagnetic indices which measure the strength of magnetospheric substorm activity and the strength of the storm-time ring current. Since the O(+) ions are almost certainly of ionospheric origin the correlations indicate that a previously unknown strong coupling mechanism existed between the magnetosphere and the ionosphere during the storm period.

Cryptococcal meningitis in an immunocompetent child: a case report and literature review.

PubMed

Othman, Norlijah; Abdullah, Nor Atiqah Ng; Wahab, Zubaidah Abdul

2004-12-01

An immunocompetent 5 year-old girl presented with pyrexia of unknown origin associated with headache. Initial investigations showed leukocytosis and an increased erythrocyte sedimentation rate. A Widal-Weil Felix test, blood film for malarial parasites, mycoplasma IgM antibody, cultures from blood and urine, full blood picture, Mantoux test, and chest x-ray were all negative. A lumbar puncture was done as part of a work-up for pyrexia of unknown origin. Cryptococcus neoformans was seen on India ink examination and confirmed on culture. She was treated with 10 weeks of intravenous amphotericin B and 8 weeks of fluconazole. Further immunological tests did not reveal any defect in the cell-mediated immune system. C. neoformans meningitis may present with non-specific symptoms and should be considered in a work-up for pyrexia of unknown origin.

13. Photocopy of photograph. Photographer unknown, circa 1940. Original photograph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph. Photographer unknown, circa 1940. Original photograph can be found in Marvine Colliery folder in the archives of the Lackawanna Historical Society, Scranton, Pennsylvania. VIEW SHOWING SOUTH AND EAST FACADES OF BREAKER, WITH OVERHEAD PIPING IN FOREGROUND AND RETAIL SCALES OFFICE AT FAR RIGHT, LOOKING NORTHWEST - Marvine Colliery, Breaker No. 2, West side Boulevard Avenue, between East Parker Street & Route 380, Scranton, Lackawanna County, PA

Complete Characterization of trans- Co(en)2Cl2[3 Fe(ox)3[.4-1/2H2O: An Extended Undergraduate Project Involving an Unknown Metal Complex.

ERIC Educational Resources Information Center

Bull, Graham S.; Searle, Graeme H.

1986-01-01

Discusses the need for student experiments involving the complete characterization of "unknown" inorganic compounds. Describes a project employing a complex metal compound. The compound contains six different components in both inert and labile complexions. Outlines the complete procedure and the preparation of the unknown compound. (TW)

Synthesis and Characterization of Aldol Condensation Products from Unknown Aldehydes and Ketones: An Inquiry-Based Experiment in the Undergraduate Laboratory

ERIC Educational Resources Information Center

Angelo, Nicholas G.; Henchey, Laura K.; Waxman, Adam J.; Canary, James W.; Arora, Paramjit S.; Wink, Donald

2007-01-01

An experiment for the undergraduate chemistry laboratory in which students perform the aldol condensation on an unknown aldehyde and an unknown ketone is described. The experiment involves the use of techniques such as TLC, column chromatography, and recrystallization, and compounds are characterized by [to the first power]H NMR, GC-MS, and FTIR.…

Synthesis and Characterization of 1,4-Dihydro-3,1-Benzoxazines and 1,2,3,4-Tetrahydroquinazolines: An Unknown Structure Determination Experiment

ERIC Educational Resources Information Center

Bendorf, Holly D.; Vebrosky, Emily N.; Eck, Brian J.

2016-01-01

In this experiment for an upper-division course in organic structure determination, each student prepares an unknown compound and characterizes the product using multiple spectroscopic techniques. The unknowns, 2-aryl-substituted 1,4-dihydro-3,1-benzoxazines and 1,2,3,4-tetrahydroquinazolines, are prepared in a single step by the condensation of…

Photocopy of photograph (original located at Mare Island Archives). Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original located at Mare Island Archives). Original photographer unknown. Lithograph of Mare Island, "showing the works already completed in the Navy Yard and the US. Frigate "Independence"; 1855. - Mare Island Naval Shipyard, East of Nave Drive, Vallejo, Solano County, CA

Properties of Radio Sources in the FRB 121102 Field

NASA Astrophysics Data System (ADS)

Bower, Geoffrey C.; Chatterjee, Shami; Wharton, Robert; Law, Casey J.; Hessels, Jason; Spolaor, Sarah; Abruzzo, Matthew W.; Bassa, Cees; Butler, Bryan J.; Cordes, James M.; Demorest, Paul; Kaspi, Victoria M.; McLaughlin, Maura; Ransom, Scott M.; Scholz, Paul; Seymour, Andrew; Spitler, Laura; Tendulkar, Shriharsh P.; PALFA Survey; VLA+AO FRB121102 Simultaneous Campaign Team; EVN FRB121102 Campaign Team; Realfast Team

2017-01-01

Fast radio bursts are millisecond duration radio pulses of unknown origin. With dispersion measures substantially in excess of expected Galactic contributions, FRBs are inferred to originate extragalactically, implying very high luminosities. Models include a wide range of high energy systems such as magnetars, merging neutron star binaries, black holes, and strong stellar magnetic fields driving coherent radio emission. Central to the mystery of FRB origins are the absence of confirmed host objects at any wavelength. This is primarily the result of the poor localization from single dish detection of FRBs. Of the approximately 20 known examples, only one, FRB 121102, has been observed to repeat. This repetition presents an opportunity for detailed follow-up if interferometric localization to arcsecond accuracy can be obtained. The Very Large Array has previously been used to localize individual pulses from pulsars and rotating radio transients to arcsecond localizaiton. We present here the results of radio observations of the field of FRB 121102 that permit us to constrain models of possible progenitors of this bursting source. These observations can characterize active galactic nuclei, stars, and other progenitor objects.

11. Photocopy of photograph. Photographer unknown, circa 1955. Original photograph ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph. Photographer unknown, circa 1955. Original photograph can be found in Marvine Colliery folder in the archives of the Lackawanna Historical Society, Scranton, Pennsylvania. VIEW SHOWING EAST AND NORTH FACADES OF BREAKER, WITH BOILER HOUSE AT FAR LEFT AND RETAIL SCALES OFFICE DIRECTLY EAST OF BREAKER, LOOKING SOUTHWEST - Marvine Colliery, Breaker No. 2, West side Boulevard Avenue, between East Parker Street & Route 380, Scranton, Lackawanna County, PA

Fever of unknown origin as the first manifestation of colonic pathology.

PubMed

Belhassen-García, Moncef; Velasco-Tirado, Virginia; López-Bernus, Amparo; Alonso-Sardón, Montserrat; Carpio-Pérez, Adela; Fuentes-Pardo, Lucía; Pardo-Lledías, Javier; Alvela-Suárez, Lucia; Romero-Alegría, Angela; Iglesias-Gomez, Alicia; Sánchez, Miguel Cordero

2013-04-01

Fever of unknown origin (FUO) is an entity caused by more than 200 diseases. Haematologic neoplasms are the most common malignant cause of FUO. Fever as a first symptom of colonic tumour pathology, both benign and malignant, is a rare form of presentation. Our work is a descriptive study of a series of 23 patients with colonic tumoral pathology who presented with fever of unknown origin. The mean age was 67.6 years; 56.5% of patients were men and 43.5% were women. Primary malignant neoplasia was the most common diagnosis. Blood cultures were positive in 45% of the samples. Coagulase-negative staphylococci were the most common cause of bacteraemia. Nine of 10 faecal occult blood tests performed were positive. Fever secondary to colon neoplasms, both benign and malignant, usually presents with a bacteraemic pattern, with positive results for blood-culture tests in a high percentage of cases.

Two similar cases of elderly women with moderate abdominal pain and pneumoperitoneum of unknown origin: a surgeon's successful conservative management.

PubMed

Vinzens, Fabrizio; Zumstein, Valentin; Bieg, Christian; Ackermann, Christoph

2016-05-26

Patients presenting with abdominal pain and pneumoperitoneum in radiological examination usually require emergency explorative laparoscopy or laparotomy. Pneumoperitoneum mostly associates with gastrointestinal perforation. There are very few cases where surgery can be avoided. We present 2 cases of pneumoperitoneum with unknown origin and successful conservative treatment. Both patients were elderly women presenting to our emergency unit, with moderate abdominal pain. There was neither medical intervention nor trauma in their medical history. Physical examination revealed mild abdominal tenderness, but no clinical sign of peritonitis. Cardiopulmonary examination remained unremarkable. Blood studies showed only slight abnormalities, in particular, inflammation parameters were not significantly increased. Finally, obtained CTs showed free abdominal gas of unknown origin in both cases. We performed conservative management with nil per os, nasogastric tube, total parenteral nutrition and prophylactic antibiotics. After 2 weeks, both were discharged home. 2016 BMJ Publishing Group Ltd.

Biomarkers for the management of pre-eclampsia in pregnant women

PubMed Central

Petla, Lakshmi Tanuja; Chikkala, Rosy; Ratnakar, K.S.; Kodati, Vijayalakshmi; Sritharan, V.

2013-01-01

Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in placenta and is characterized by widespread maternal endothelial dysfunction. Till date, delivery of placenta is the only cure for the disease. So, there is a need for the identification of highly specific and sensitive biochemical markers that would allow early identification of patients at risk and thus help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination, that may help in predicting women who are likely to develop PE. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in predicting pre-eclampsia. PMID:24056556

Uncertainty quantification and experimental design based on unsupervised machine learning identification of contaminant sources and groundwater types using hydrogeochemical data

NASA Astrophysics Data System (ADS)

Vesselinov, V. V.

2017-12-01

Identification of the original groundwater types present in geochemical mixtures observed in an aquifer is a challenging but very important task. Frequently, some of the groundwater types are related to different infiltration and/or contamination sources associated with various geochemical signatures and origins. The characterization of groundwater mixing processes typically requires solving complex inverse models representing groundwater flow and geochemical transport in the aquifer, where the inverse analysis accounts for available site data. Usually, the model is calibrated against the available data characterizing the spatial and temporal distribution of the observed geochemical species. Numerous geochemical constituents and processes may need to be simulated in these models which further complicates the analyses. As a result, these types of model analyses are typically extremely challenging. Here, we demonstrate a new contaminant source identification approach that performs decomposition of the observation mixtures based on Nonnegative Matrix Factorization (NMF) method for Blind Source Separation (BSS), coupled with a custom semi-supervised clustering algorithm. Our methodology, called NMFk, is capable of identifying (a) the number of groundwater types and (b) the original geochemical concentration of the contaminant sources from measured geochemical mixtures with unknown mixing ratios without any additional site information. We also demonstrate how NMFk can be extended to perform uncertainty quantification and experimental design related to real-world site characterization. The NMFk algorithm works with geochemical data represented in the form of concentrations, ratios (of two constituents; for example, isotope ratios), and delta notations (standard normalized stable isotope ratios). The NMFk algorithm has been extensively tested on synthetic datasets; NMFk analyses have been actively performed on real-world data collected at the Los Alamos National Laboratory (LANL) groundwater sites related to Chromium and RDX contamination.

16. Photocopy of original USRS photograph (from original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of original USRS photograph (from original print in the Umatilla Project History 1918, on file at National Archives, Rocky Mountain Region, Denver, Colorado) Photographer unknown, ca. 1918. Office of U.S. Reclamation Service - Hermiston, Umatilla Project, Oregon - Former Umatilla Project Headquarters Buildings, Office, Hermiston, Umatilla County, OR

Genomic and genotyping characterization of haplotype-based polymorphic microsatellites in Prunus

USDA-ARS?s Scientific Manuscript database

Efficient utilization of microsatellites in genetic studies remains impeded largely due to the unknown status of their primer reliability, chromosomal location, and allele polymorphism. Discovery and characterization of microsatellite polymorphisms in a taxon will disclose the unknowns and gain new ...

Marked improvement of vulvovaginitis of unknown origin in a pediatric patient--case report.

PubMed

Check, J H; Cohen, R

2014-01-01

To present a novel therapy for pediatric vulvovaginitis. An eight-year-old girl with persistent severe vulvovaginitis of unknown origin also complained of unexplained weight gain and sudden academic difficulties. She was treated with dextroamphetamine sulfate. She not only showed very quick and excellent relief from her vulvovaginitis but she also lost weight and improved her mentality. Sympathomimetic amine therapy may benefit pediatric vulvovaginitis when an infectious cause cannot be ascertained.

Fever of unknown origin (FUO) due to Legionnaire's disease.

PubMed

Muñoz-Gómez, Sigridh; Cunha, Burke A

2015-01-01

Fevers of unknown origin (FUOs) may be due to any of over 200 different disorders. We present a most unusual case of an FUO in a returning traveler from the Dominican Republic. Work-up for Q fever, Brucellosis, Bartonella, malaria and HIV were negative, but very highly elevated ESRs and ferritin levels suggested possible Legionnaire's disease. This is the third reported case of Legionnaire's disease presenting as an FUO. Copyright © 2015 Elsevier Inc. All rights reserved.

10. Photocopy of photograph (original print from Southern Pacific Transportation ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of photograph (original print from Southern Pacific Transportation Company) ca. 1916, photographer unknown VIEW OF ORIGINAL PACIFIC ELECTRIC RAILWAY LYNWOOD SHELTER SHED - Lynwood Pacific Electric Railway Depot, 11453 Long Beach Boulevard, Lynwood, Los Angeles County, CA

Lateral Spread of Orientation Selectivity in V1 is Controlled by Intracortical Cooperativity

PubMed Central

Chavane, Frédéric; Sharon, Dahlia; Jancke, Dirk; Marre, Olivier; Frégnac, Yves; Grinvald, Amiram

2011-01-01

Neurons in the primary visual cortex receive subliminal information originating from the periphery of their receptive fields (RF) through a variety of cortical connections. In the cat primary visual cortex, long-range horizontal axons have been reported to preferentially bind to distant columns of similar orientation preferences, whereas feedback connections from higher visual areas provide a more diverse functional input. To understand the role of these lateral interactions, it is crucial to characterize their effective functional connectivity and tuning properties. However, the overall functional impact of cortical lateral connections, whatever their anatomical origin, is unknown since it has never been directly characterized. Using direct measurements of postsynaptic integration in cat areas 17 and 18, we performed multi-scale assessments of the functional impact of visually driven lateral networks. Voltage-sensitive dye imaging showed that local oriented stimuli evoke an orientation-selective activity that remains confined to the cortical feedforward imprint of the stimulus. Beyond a distance of one hypercolumn, the lateral spread of cortical activity gradually lost its orientation preference approximated as an exponential with a space constant of about 1 mm. Intracellular recordings showed that this loss of orientation selectivity arises from the diversity of converging synaptic input patterns originating from outside the classical RF. In contrast, when the stimulus size was increased, we observed orientation-selective spread of activation beyond the feedforward imprint. We conclude that stimulus-induced cooperativity enhances the long-range orientation-selective spread. PMID:21629708

Systemic lupus erythematosus associated with acute Epstein-Barr virus infection.

PubMed

Dror, Y; Blachar, Y; Cohen, P; Livni, N; Rosenmann, E; Ashkenazi, A

1998-11-01

Systemic lupus erythematosus (SLE) is a multisystem disease of unknown origin, characterized by a variety of autoimmune phenomena. Viruses have long been postulated to play a role in its pathogenesis. Several observations suggested a link between Epstein-Barr virus (EBV) and SLE. We describe a 14-year-old girl who presented with acute onset of SLE concurrently with clinical and laboratory findings consistent with EBV-induced infectious mononucleosis (IM). Evidence for acute EBV infection was confirmed by serological studies and detection of specific EBV antigens on kidney biopsy. This close association between EBV and SLE suggests a possible role of the virus in the pathogenesis of SLE in this patient.

Hazardous-waste-characterization survey of unknown drums at the 21st Tactical Fighter Wing, Elmendorf and Shemya Air Force Bases, and Galena and King Salmon Airports, Alaska. Final report 2-13 Aug 91

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bishop, M.S.

1991-12-01

At the request of the USAF Regional Hospital Elmendorf/SGPB (PACAF), the Armstrong Laboratory, Occupational and Environmental Health Directorate, conducted a hazardous waste characterization survey of unknown drums at Elmendorf AFB from 2 Aug - 13 Aug 91. The scope of the survey was to sample and characterize drums of unknown material stored at Elmendorf AFB, Shemya AFB, and Galena and King Salmon Airports. Several waste streams were sampled at Elmendorf AFB to revalidate sample results from a previous survey.

MoCha: Molecular Characterization of Unknown Pathways.

PubMed

Lobo, Daniel; Hammelman, Jennifer; Levin, Michael

2016-04-01

Automated methods for the reverse-engineering of complex regulatory networks are paving the way for the inference of mechanistic comprehensive models directly from experimental data. These novel methods can infer not only the relations and parameters of the known molecules defined in their input datasets, but also unknown components and pathways identified as necessary by the automated algorithms. Identifying the molecular nature of these unknown components is a crucial step for making testable predictions and experimentally validating the models, yet no specific and efficient tools exist to aid in this process. To this end, we present here MoCha (Molecular Characterization), a tool optimized for the search of unknown proteins and their pathways from a given set of known interacting proteins. MoCha uses the comprehensive dataset of protein-protein interactions provided by the STRING database, which currently includes more than a billion interactions from over 2,000 organisms. MoCha is highly optimized, performing typical searches within seconds. We demonstrate the use of MoCha with the characterization of unknown components from reverse-engineered models from the literature. MoCha is useful for working on network models by hand or as a downstream step of a model inference engine workflow and represents a valuable and efficient tool for the characterization of unknown pathways using known data from thousands of organisms. MoCha and its source code are freely available online under the GPLv3 license.

Lesson of the month 1: Subacute thyroiditis: a rare cause of fever of unknown origin.

PubMed

Bahowairath, Fatima Amar; Woodhouse, Nicholas; Hussain, Samir; Busaidi, Mujahid Al

2017-02-01

Fever of unknown origin (FUO) is sometimes a diagnostic dilemma for clinicians. Endocrine causes reported in the literature include subacute thyroiditis, thyrotoxicosis, adrenal insufficiency and pheochromocytoma. Among these, subacute thyroiditis is often overlooked as it can occasionally lack typical symptoms. This case illustrates the fact that subacute thyroiditis should be considered as a possible cause of fever even if signs and symptoms of hyperthyroidism and thyroid tenderness are absent. © Royal College of Physicians 2017. All rights reserved.

7. Photographic copy of photograph, date unknown (original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photographic copy of photograph, date unknown (original print in possession of James E. Zielinski Earth Tech, Huntsville, AL). Pan American World Airways, photographer. Aerial view (north to south) of missile launch area. Warhead handling building can be seen at the bottom center of the picture and the universal missile building in the middle right. In the distance can be seen the missile site control building and related structures - Stanley R. Mickelsen Safeguard Complex, Missile Launch Area, Within Exclusion Area, Nekoma, Cavalier County, ND

Fever of Unknown Origin in Childhood.

PubMed

Chusid, Michael J

2017-02-01

Childhood fever of unknown origin (FUO) is most often related to an underlying infection but can also be associated with a variety of neoplastic, rheumatologic, and inflammatory conditions. Repeated, focused reviews of patient history and physical examination are often helpful in suggesting a likely diagnosis. Diagnostic workup should be staged, usually leaving invasive testing for last. Advances in molecular genetic techniques have increased the importance of these assays in the diagnosis of FUO in children. Copyright © 2016 Elsevier Inc. All rights reserved.

Metastatic brain tumor

MedlinePlus

... the brain, the type of tissue involved, the original location of the tumor, and other factors. In rare cases, doctors do not know the original location. This is called cancer of unknown primary ( ...

18. Photocopy of original postcard, (original in Forest Service Office, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of original postcard, (original in Forest Service Office, Elkins, WV, 'U. S. Forest Nursery with CCC Camp in Background-Parsons, W. Va.'), photographer unknown, ca. 1936. AERIAL VIEW EAST, ORIGINAL WASH HOUSE, WORKSHOP/WAREHOUSE, TWO EQUIPMENT BUILDINGS (DEMOLISHED) IN FOREGROUND, CCC CAMP PARSONS IN BACKGROUND. - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

Genetic loci with parent-of-origin effects cause hybrid seed lethality in crosses between Mimulus species.

PubMed

Garner, Austin G; Kenney, Amanda M; Fishman, Lila; Sweigart, Andrea L

2016-07-01

In flowering plants, F1 hybrid seed lethality is a common outcome of crosses between closely related diploid species, but the genetic basis of this early-acting and potentially widespread form of postzygotic reproductive isolation is largely unknown. We intercrossed two closely related species of monkeyflower, Mimulus guttatus and Mimulus tilingii, to characterize the mechanisms and strength of postzygotic reproductive isolation. Then, using a reciprocal backcross design, we performed high-resolution genetic mapping to determine the genetic architecture of hybrid seed lethality and directly test for loci with parent-of-origin effects. We found that F1 hybrid seed lethality is an exceptionally strong isolating barrier between Mimulus species, with reciprocal crosses producing < 1% viable seeds. This form of postzygotic reproductive isolation appears to be highly polygenic, indicating that multiple incompatibility loci have accumulated rapidly between these closely related Mimulus species. It is also primarily caused by genetic loci with parent-of-origin effects, suggesting a possible role for imprinted genes in the evolution of Mimulus hybrid seed lethality. Our findings suggest that divergence in loci with parent-of-origin effects, which is probably driven by genomic coevolution within lineages, might be an important source of hybrid incompatibilities between flowering plant species. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Archaeology Through Computational Linguistics: Inscription Statistics Predict Excavation Sites of Indus Valley Artifacts.

PubMed

Recchia, Gabriel L; Louwerse, Max M

2016-11-01

Computational techniques comparing co-occurrences of city names in texts allow the relative longitudes and latitudes of cities to be estimated algorithmically. However, these techniques have not been applied to estimate the provenance of artifacts with unknown origins. Here, we estimate the geographic origin of artifacts from the Indus Valley Civilization, applying methods commonly used in cognitive science to the Indus script. We show that these methods can accurately predict the relative locations of archeological sites on the basis of artifacts of known provenance, and we further apply these techniques to determine the most probable excavation sites of four sealings of unknown provenance. These findings suggest that inscription statistics reflect historical interactions among locations in the Indus Valley region, and they illustrate how computational methods can help localize inscribed archeological artifacts of unknown origin. The success of this method offers opportunities for the cognitive sciences in general and for computational anthropology specifically. Copyright © 2015 Cognitive Science Society, Inc.

[Characterization of cases contravening of regulations regarding primary aromatic amines originating from azo dyes in commercial textile products and leather products in European Union].

PubMed

Kawakami, Tsuyoshi; Isama, Kazuo; Ikarashi, Yoshiaki

2013-01-01

Contraventions of regulations regarding primary aromatic amines (PAAs) originating from azo dyes in commercial textile products and leather products in European Union (EU), notified in the period between 2006 and 2012 were collected from the Rapid Alert System for non-food consumer products (RAPEX), were characterized. Various types of products (clothes, footwear, bedding, etc.) and their raw materials (cotton, silk, viscose, leather, etc.) were reported to have contravened the regulations. The contravention frequencies for products made in China and India were higher than those for other countries. Ten percentage of the country in which the reported products were produced was unknown. The notification frequencies for benzidine and 4-aminoazobenzene were higher than those for other PAAs. Contravention of regulations regarding benzidine, 4-aminoazobenzene, and 3,3'-dimethoxybenzidine were notified every year. Contraventions of regulations regarding five PAAs--classified as IARC group 1--were notified one or several times. Since the scale of the survey conducted in Japan were small compared with RAPEX, it is necessary that many kinds and number of products should be surveyed in Japan. In addition, it is also necessary to pay attention to 4-aminoazobenzene, while it has not been detected in the previous studies conducted in Japan.

31. Photocopy of photograph (original print in Helgesen Collection) Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Photocopy of photograph (original print in Helgesen Collection) Photographer unknown 1928 MEN'S MEZZANINE SMOKING ROOM - B. F. Keith Memorial Theatre, 539 Washington Street, Boston, Suffolk County, MA

Nature and origin of the violet stains on the walls of a Roman tomb.

PubMed

Dominguez-Moñino, Irene; Diaz-Herraiz, Marta; Jurado, Valme; Laiz, Leonila; Miller, Ana Z; Santos, Juan Luis; Alonso, Esteban; Saiz-Jimenez, Cesareo

2017-11-15

The Circular Mausoleum tomb (Roman Necropolis of Carmona, Spain) dates back from the first century AD and is characterized by a dense microbial (phototrophic) colonization on the walls and ceiling. However, some walls exhibited an important number of violet stains of unknown origin. The microbial communities of these violet stains are mainly composed of cyanobacteria, streptomycetes and fungi. A strain of Streptomyces parvus, isolated from the walls, produces a violet pigment in culture media. High performance liquid chromatography-mass spectrometry of the culture extracts obtained from this Streptomyces revealed the presence of a few granaticins, pigments with a benzoisochromanequinone structure. When metabolically active in the tomb, S. parvus synthesizes the pigments that diffuse into the mortar. During rain and/or wetting periods, the pigments are solubilized by alkaline waters and elute from the starting position to the surrounding mortar, enlarging the pigmented area and thus contributing to this exceptional biodeterioration phenomenon. Copyright © 2017 Elsevier B.V. All rights reserved.

A genetic-algorithm-based remnant grey prediction model for energy demand forecasting.

PubMed

Hu, Yi-Chung

2017-01-01

Energy demand is an important economic index, and demand forecasting has played a significant role in drawing up energy development plans for cities or countries. As the use of large datasets and statistical assumptions is often impractical to forecast energy demand, the GM(1,1) model is commonly used because of its simplicity and ability to characterize an unknown system by using a limited number of data points to construct a time series model. This paper proposes a genetic-algorithm-based remnant GM(1,1) (GARGM(1,1)) with sign estimation to further improve the forecasting accuracy of the original GM(1,1) model. The distinctive feature of GARGM(1,1) is that it simultaneously optimizes the parameter specifications of the original and its residual models by using the GA. The results of experiments pertaining to a real case of energy demand in China showed that the proposed GARGM(1,1) outperforms other remnant GM(1,1) variants.

A genetic-algorithm-based remnant grey prediction model for energy demand forecasting

PubMed Central

2017-01-01

Energy demand is an important economic index, and demand forecasting has played a significant role in drawing up energy development plans for cities or countries. As the use of large datasets and statistical assumptions is often impractical to forecast energy demand, the GM(1,1) model is commonly used because of its simplicity and ability to characterize an unknown system by using a limited number of data points to construct a time series model. This paper proposes a genetic-algorithm-based remnant GM(1,1) (GARGM(1,1)) with sign estimation to further improve the forecasting accuracy of the original GM(1,1) model. The distinctive feature of GARGM(1,1) is that it simultaneously optimizes the parameter specifications of the original and its residual models by using the GA. The results of experiments pertaining to a real case of energy demand in China showed that the proposed GARGM(1,1) outperforms other remnant GM(1,1) variants. PMID:28981548

45. Photocopy of negative (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Photocopy of negative (original in possession of Chiricahua National Monument), photographer unknown, undated RANCH HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

40. Photocopy of negative (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Photocopy of negative (original in possession of Chiricahua National Monument), photographer unknown, 1935 RANCH HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

42. Photocopy of negative (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Photocopy of negative (original in possession of Chiricahua National Monument), photographer unknown, 1942 RANCH HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

43. Photocopy of negative (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photocopy of negative (original in possession of Chiricahua National Monument), photographer unknown, 1950 RANCH HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

46. Photocopy of negative (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Photocopy of negative (original in possession of Chiricahua National Monument), photographer unknown, undated RANCH HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

17. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF MAGNOLIA AVENUE - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

51. Ground floor, southeast corner, looking southeast in mezzanine (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

51. Ground floor, southeast corner, looking southeast in mezzanine (original function unknown) - Sheffield Farms Milk Plant, 1075 Webster Avenue (southwest corner of 166th Street), Bronx, Bronx County, NY

12. Photocopy of photograph, (original in Forest Service Office, Elkins, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of photograph, (original in Forest Service Office, Elkins, WV, photo #305568, 'show me tour'), photographer and date unknown. VIEW SOUTHWEST, NURSERY MANAGER'S RESIDENCE, NURSERY OFFICE, WORKSHOP/WAREHOUSE, ORIGINAL WASH HOUSE. - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

Quarry identification of historical building materials by means of laser induced breakdown spectroscopy, X-ray fluorescence and chemometric analysis

NASA Astrophysics Data System (ADS)

Colao, F.; Fantoni, R.; Ortiz, P.; Vazquez, M. A.; Martin, J. M.; Ortiz, R.; Idris, N.

2010-08-01

To characterize historical building materials according to the geographic origin of the quarries from which they have been mined, the relative content of major and trace elements were determined by means of Laser Induced Breakdown Spectroscopy (LIBS) and X-ray Fluorescence (XRF) techniques. 48 different specimens were studied and the entire samples' set was divided in two different groups: the first, used as reference set, was composed by samples mined from eight different quarries located in Seville province; the second group was composed by specimens of unknown provenance collected in several historical buildings and churches in the city of Seville. Data reduction and analysis on laser induced breakdown spectroscopy and X-ray fluorescence measurements was performed using multivariate statistical approach, namely the Linear Discriminant Analysis (LDA), Principal Component Analysis (PCA) and Soft Independent Modeling of Class Analogy (SIMCA). A clear separation among reference sample materials mined from different quarries was observed in Principal Components (PC) score plots, then a supervised soft independent modeling of class analogy classification was trained and run, aiming to assess the provenance of unknown samples according to their elemental content. The obtained results were compared with the provenance assignments made on the basis of petrographical description. This work gives experimental evidence that laser induced breakdown spectroscopy measurements on a relatively small set of elements is a fast and effective method for the purpose of origin identification.

Developmental cardiovascular physiology of the olive ridley sea turtle (Lepidochelys olivacea).

PubMed

Crossley, Dane Alan; Crossley, Janna Lee; Smith, Camilla; Harfush, Martha; Sánchez-Sánchez, Hermilo; Garduño-Paz, Mónica Vanessa; Méndez-Sánchez, José Fernando

2017-09-01

Our understanding of reptilian cardiovascular development and regulation has increased substantially for two species the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina) during the past two decades. However, what we know about cardiovascular maturation in many other species remains poorly understood or unknown. Embryonic sea turtles have been studied to understand the maturation of metabolic function, but these studies have not addressed the cardiovascular system. Although prior studies have been pivotal in characterizing development, and factors that influence it, the development of cardiovascular function, which supplies metabolic function, is unknown in sea turtles. During our investigation we focused on quantifying how cardiovascular morphological and functional parameters change, to provide basic knowledge of development in the olive ridley sea turtle (Lepidochelys olivacea). Embryonic mass, as well as mass of the heart, lungs, liver, kidney, and brain increased during turtle embryo development. Although heart rate was constant during this developmental period, arterial pressure approximately doubled. Further, while embryonic olive ridley sea turtles lacked cholinergic tone on heart rate, there was a pronounced beta adrenergic tone on heart rate that decreased in strength at 90% of incubation. This beta adrenergic tone may be partially originating from the sympathetic nervous system at 90% of incubation, with the majority originating from circulating catecholamines. Data indicates that olive ridley sea turtles share traits of embryonic functional cardiovascular maturation with the American alligator (Alligator mississippiensis) but not the common snapping turtle (Chelydra serpentina). Copyright © 2017 Elsevier Inc. All rights reserved.

16. Photocopy of photograph (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of photograph (original in possession of Chiricahua National Monument), photographer unknown, c.1917 LILLIANA AND HILDEGARD ERICKSON IN FRONT OF RANCH HOUSE - Faraway Ranch, Willcox, Cochise County, AZ

19. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF CITRUS EXPERIMENT STATION - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

5. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF ARLINGTON HEIGHTS CITRUS GROVES - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

10. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF DUFFERIN AVENUE AND VEHICLE - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

Infectious causes of fever of unknown origin.

PubMed

McGregor, Alastair C; Moore, David A

2015-06-01

The causes of fever of unknown origin (FUO) are changing because advances in clinical practice and diagnostics have facilitated the identification of some infections. A variety of bacterial infections can cause FUO, and these can be divided into those that are easy to identify using culture and those that require serological or molecular tests for identification. A number of viral, parasitic and fungal infections can also cause prolonged fever. This article summarises the clinical features and diagnostic strategy of these infections. © Royal College of Physicians 2015. All rights reserved.

Non-alcoholic beverages, unknown influence on cell proliferation - an in vitro study.

PubMed

Nowacki, Maciej; Adamowicz, Jan; Olkowska, Joanna; Pietkun, Katarzyna; Kloskowski, Tomasz; Bajek, Anna; Drewa, Tomasz

2014-01-01

The aim of the presented study was to check differences between 'Diet' and 'non-Diet' soft drinks on cell proliferation. Coca Cola and Pepsi Cola of different origin and their dietetic versions were examined at concentrations of 2% and 4%. Fructose and glucose as well as medium alone (control) were examined. Cell number was higher in media supplemented with soft drinks, compared to control. Proliferation depended on the soft drink concentration and its origin, but not on sugar and calorific content. An unknown factor is responsible for the increase in proliferation.

4. Photocopy of photograph, JANE MOSELEY (VESSEL 53) TIED UP ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of photograph, JANE MOSELEY (VESSEL 53) TIED UP AT DOCK IN UNKNOWN LOCATION. Date and photographer unknown. (Original in Mariners Museum, Newport News, Virginia, negative #625) - Shooters Island, Ships Graveyard, Vessel No. 53, Newark Bay, Staten Island (subdivision), Richmond County, NY

37. Photocopy of photograph (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. Photocopy of photograph (original in possession of WACC), photographer unknown, c.1930 VIEW OF MAIN HOUSE LOOKING NORTHEAST - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

47. Photocopy of negative (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Photocopy of negative (original in possession of Chiricahua National Monument) photographer unknown, undated RANCH HOUSE AND ORCHARD IN SNOW - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

1. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3810) Photographer unknown, 1923-25 GRANADA PLAZA AND GRANADA BOULEVARD - Granada Plaza, Coral Gables, Miami-Dade County, FL

16. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF MAGNOLIA AVENUE WITH ELECTRIC STREET CAR - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

19. Photocopy of photograph (original in possession of NYC Economic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photocopy of photograph (original in possession of NYC Economic Development Corp.) Photographer and date unknown PIER 4 CONNECTING BRIDGE AND WAREHOUSE A - Brooklyn Army Supply Base, Pier 4, Brooklyn, Kings County, NY

11. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF WORKERS HARVESTING ORANGES IN GROVES - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

18. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF MISSION INN, SEVENTH STREET ENTRANCE - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

Photothermal and infrared thermography characterizations of thermal diffusion in hydroxyapatite materials

NASA Astrophysics Data System (ADS)

Bante-Guerra, J.; Conde-Contreras, M.; Trujillo, S.; Martinez-Torres, P.; Cruz-Jimenez, B.; Quintana, P.; Alvarado-Gil, J. J.

2009-02-01

Non destructive analysis of hydroxyapatite materials is an active research area mainly in the study of dental pieces and bones due to the importance these pieces have in medicine, archeology, dentistry, forensics and anthropology. Infrared thermography and photothermal techniques constitute highly valuable tools in those cases. In this work the quantitative analysis of thermal diffusion in bones is presented. The results obtained using thermographic images are compared with the ones obtained from the photothermal radiometry. Special emphasis is done in the analysis of samples with previous thermal damage. Our results show that the treatments induce changes in the physical properties of the samples. These results could be useful in the identification of the agents that induced modifications of unknown origin in hydroxyapatite structures.

38. Photographic copy of photograph, photographer unknown, 26 March 1915 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

38. Photographic copy of photograph, photographer unknown, 26 March 1915 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). " Dredge after failure of control dam." - Keechelus Dam, Yakima River, 10 miles northwest of Easton, Easton, Kittitas County, WA

39. Photographic copy of photograph, photographer unknown, 26 March 1915 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Photographic copy of photograph, photographer unknown, 26 March 1915 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "View of control dam after failure." - Keechelus Dam, Yakima River, 10 miles northwest of Easton, Easton, Kittitas County, WA

Use of indicator chemicals to characterize the plastic fragments ingested by Laysan albatross.

PubMed

Nilsen, Frances; David Hyrenbach, K; Fang, Jiasong; Jensen, Brenda

2014-10-15

Laysan albatross (Phoebastria immutabilis) ingest plastic marine debris of a wide range of shape, sizes and sources. To better characterize this plastic and provide insights regarding its provenance and persistence in the environment, we developed a simple method to classify plastic fragments of unknown origin according to the resin codes used by the Society of Plastics Industry. Known plastics were analyzed by gas chromatography-mass spectroscopy (GC-MS) to identify indicator chemicals characteristic of each plastic resin. Application of this method to fragments of ingested plastic debris from boluses of Laysan albatross from Kure Atoll, Hawai'i, yielded proportions of 0.8% High Density Polyethylene, 6.8% Polystyrene, 8.5% Polyethylene Terephthalate, 20.5% Polyvinyl Chloride and 68.4% Polypropylene. Some fragments were composed of multiple resin types. These results suggest that infrequently recycled plastics are the dominant fragments ingested by albatross, and that these are the most prevalent and persistent resin types in the marine environment. Copyright © 2014 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosatelli, M.C.; Faa, V.; Sardu, R.

This study reports the molecular characterization of [beta]-thalassemia in the Sardinian population. Three thousand [beta]-thalassemia chromosomes from prospective parents presenting at the genetic service were initially analyzed by dot blot analysis with oligonucleotide probes complementary to the most common [beta]-thalassemia mutations in the Mediterranean at-risk populations. The mutation which remained uncharacterized by this approach were defined by denaturing gradient gel electrophoresis (DGGE) followed by direct sequence analysis on amplified DNA. The authors reconfirmed that the predominant mutation in the Sardinian population is the codon 39 nonsense mutation, which accounts for 95.7% of the [beta]-thalassemia chromosomes. The other two relatively commonmore » mutations are frameshifts at codon 6 (2.1%) and at codon 76 (0.7%), relatively uncommon in other Mediterranean-origin populations. In this study they have detected a novel [beta]-thalassemia mutation, i.e., a frameshift at codon 1, in three [beta]-thalassemia chromosomes. The DGGE procedure followed by direct sequencing on amplified DNA is a powerful approach for the characterization of unknown mutations in this genetic system.« less

44. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. May 4, 1949. PERSPECTIVE DRAWING, BIRD'S-EYE VIEW - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

38. Photocopy of photograph (original in possession of WACC) photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

38. Photocopy of photograph (original in possession of WACC) photographer unknown, c.1930 'GARFIELD' FIREPLACE AND PART OF NORTH BACK WALL - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

39. Photocopy of photograph (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Photocopy of photograph (original in possession of WACC), photographer unknown, c.1930's GUEST DINING ROOM WITH TABLE LAID FOR GUESTS - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

14. Photocopy of negative (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of negative (original in possession of WACC), photographer unknown, c.1908 EMMA AND NEIL ERICKSON IN FRONT OF BOARD AND BATTEN SOUTH WALL OF MAIN HOUSE - Faraway Ranch, Willcox, Cochise County, AZ

34. Photocopy of photograph (original in possession of Western Archeological ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Photocopy of photograph (original in possession of Western Archeological and Conservation Center, (WACC), Tucson, Arizona), photographer unknown, c.1910 MAIN HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

7. Photocopy of photograph (original in possession of NYC Economic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph (original in possession of NYC Economic Development Corp.) Photographer unknown, circa 1983) OVERALL VIEW OF THE BROOKLYN ARMY TERMINAL, LOOKING NORTHEAST - Brooklyn Army Supply Base, Pier 2, Brooklyn, Kings County, NY

9. Photocopy of photograph (original print at Riveside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original print at Riveside Library, Local History Collection), photographer unknown, ca. 1916. VIEW OF MAUDE STREET AT VICTORIA AVENUE LOOKING SOUTH - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

14. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF OSBORNE CAMP AND STABLES, ARLINGTON HEIGHTS FRUIT COMPANY - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

7. Photocopy of drawing (Original in collection of the Department ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of drawing (Original in collection of the Department of Treasury) William Martin Aiken, Supervising architect, date unknown TOWER - U.S. Post Office Department, 1100 Pennsylvania Avenue Northwest, Washington, District of Columbia, DC

7. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3828) Photographer unknown, 1923-25 SEGOVIA PLAZA - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

9. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3812) Photographer unknown, 1923-25 DESOTO PLAZA FOUNTAIN - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

14. Photocopy of photograph (Original in the collection of Baltimore ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph (Original in the collection of Baltimore and Ohio Railroad) Unknown, Photographer, November 1956 PERSPECTIVE VIEW OF EAST (FRONT) AND SOUTH SIDE - John Brown Fort, Shenandoah Street, Harpers Ferry, Jefferson County, WV

14. Photographic copy of original Survey Data drawing of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photographic copy of original Survey Data drawing of the Loleta Dams, date and engineer unknown (original in possession of United States Department of Agriculture-Forest Service-Allegheny National Forest). - Loleta Recreation Area, Lower Dam, 6 miles Southeast of interesection of State Route 24041 & State Route 66, Loleta, Elk County, PA

13. Photographic copy of original Design For New Sluice Gate ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photographic copy of original Design For New Sluice Gate drawing, date and engineer unknown (original in possession of United States Department of Agriculture-Forest Service-Allegheny National Forest). - Loleta Recreation Area, Lower Dam, 6 miles Southeast of interesection of State Route 24041 & State Route 66, Loleta, Elk County, PA

Some news from the unknown soldier, the Peyer's patch macrophage.

PubMed

Wagner, Camille; Bonnardel, Johnny; Da Silva, Clément; Martens, Liesbet; Gorvel, Jean-Pierre; Lelouard, Hugues

2018-01-31

In mammals, macrophages (MF) are present in virtually all tissues where they serve many different functions linked primarily to the maintenance of homeostasis, innate defense against pathogens, tissue repair and metabolism. Although some of these functions appear common to all tissues, others are specific to the homing tissue. Thus, MF become adapted to perform particular functions in a given tissue. Accordingly, MF express common markers but also sets of tissue-specific markers linked to dedicated functions. One of the largest pool of MF in the body lines up the wall of the gut. Located in the small intestine, Peyer's patches (PP) are primary antigen sampling and mucosal immune response inductive sites. Surprisingly, although markers of intestinal MF, such as F4/80, have been identified more than 30 years ago, MF of PP escaped any kind of phenotypic description and remained "unknown" for decades. In absence of MF identification, the characterization of the PP mononuclear phagocyte system (MPS) functions has been impaired. However, taking into account that PP are privileged sites of entry for pathogens, it is important to understand how the latter are handled by and/or escape the PP MPS, especially MF, which role in killing invaders is well known. This review focuses on recent advances on the PP MPS, which have allowed, through new criteria of PP phagocyte subset identification, the characterization of PP MF origin, diversity, specificity, location and functions. Copyright © 2018 Elsevier Inc. All rights reserved.

[Pharmacovigilance in Portugal: Activity of the Central Pharmacovigilance Unit].

PubMed

Batel-Marques, Francisco; Mendes, Diogo; Alves, Carlos; Penedones, Ana; Dias, Patricia; Martins, Angelina; Santiago, Luiz Miguel; Fontes-Ribeiro, Carlos; Caramona, Margarida; Macedo, Tice

2015-01-01

The aim of this study was to characterize the spontaneous reports of adverse events that were received by the Central Portugal Regional Pharmacovigilance Unit. Spontaneous reports received between 01/2001 and 12/2013 were considered. The annual reporting ratios were estimated. The cases were characterized according to their seriousness, previous description, causality assessment, origin and professional group of the reporter, type of adverse event and pharmacotherapeutic groups of the suspected drugs most frequently reported. The Pharmacovigilance Unit received 2408 reports that contained 5749 adverse events. In 2013, the reporting rate was estimated at 171 reports per million inhabitants. Fifty-five percent of the reports were assessed as serious. Ninety percent of the cases were assessed as being at least possibly related with the suspected drug. The suspected drugs most frequently reported were anti-infectives for systemic use (n = 809, 33%). The most frequently reported adverse events were "Skin and subcutaneous tissue disorders" (n = 1139, 20%). There were 154 (6.4%) reports resulting in life-threatening situations and/or death, and 88 (3.6%) containing at least one adverse event assessed as serious, unknown and certain or probable. The present results are in line with those found in other studies, namely the seriousness and type of the adverse events and the pharmacotherapeutic groups of the most frequently reported suspected drugs. In the last years, the Central Portugal Regional Pharmacovigilance Unit has registered a growth in the reporting rate in general, as well as an increase in the reporting of unknown and serious adverse drug reactions.

30. Photocopy of blueprint. PLAN, ELEVATION, END SECTION, DETAIL OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Photocopy of blueprint. PLAN, ELEVATION, END SECTION, DETAIL OF DECK SYSTEM AND LOAD COMPUTATION. Preparer unknown, date unknown, but probably ca. 1932. (Original in possession of the Washington County Highway Department.) - Hegeman-Hill Street Bridge, Spanning Batten Kill, .65 mile West of Greenwich, Easton, Washington County, NY

46. Photographic copy of photograph, photographer unknown, 24 July 1916 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Photographic copy of photograph, photographer unknown, 24 July 1916 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "Scheme for shelter for cransemen on bucyrus steam shovel." - Keechelus Dam, Yakima River, 10 miles northwest of Easton, Easton, Kittitas County, WA

6. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. October 31, 1950. BEV-331. MAGNET ROOM. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

18. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. January 12, 1950. BEV-195. ION GUN INJECTOR. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

43. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. March 28, 1950. BEV-226. BEVATRON BUILDING CONSTRUCTION. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

27. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

27. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. August 18, 1958. Bubble Chamber 605. BUBBLE CHAMBER ASSEMBLY - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

14. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. November 22, 1963. BEV-3467. ACCELERATION DIAGRAM. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

13. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 4, 1957. BEV-128. PROGRESS--MAGNET REPAIR. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

56. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

56. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. December 4, 1953. BEV-627. OVERALL VIEW OF BEVATRON - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

40. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. March, 1949. BEV 4903-00020. GRADING-SITE WORK FOR BEVATRON - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

30. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. October 6, 1955. BEV-943. ANTI-PROTON EXPERIMENT. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

5. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. August 25, 1950. BEV-307. BEVATRON MAGNET FOUNDATION. B-51 - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

4. Photocopy of photograph (original in possession of Western Archeological ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of photograph (original in possession of Western Archeological and Conservation Center (WACC), Tucson, Arizona), photographer unknown, undated NEIL ERICKSON WORKING OUTSIDE OFFICE/GARAGE WHEN IT WAS NEW - Faraway Ranch, Office-Garage, Willcox, Cochise County, AZ

4. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3686) Photographer unknown, 1923-25 GRANADA ENTRANCE, TAMIAMI TRAIL - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

9. Photocopy of photograph (original in possession of NYC Economic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original in possession of NYC Economic Development Corp.) Photographer and date unknown VIEW BETWEEN PIERS 2 AND 3, LOOKING FROM WAREHOUSE ROOF - Brooklyn Army Supply Base, Pier 2, Brooklyn, Kings County, NY

8. Photocopy of photograph (original photograph in possession of Coronado ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of photograph (original photograph in possession of Coronado Historical Association). Photographer Unknown, circa 1922. HEILMAN VILLAS FROM ORANGE AVENUE - Heilman Villas, 706-720 Orange Avenue & 1060-1090 Seventh Street, Coronado, San Diego County, CA

12. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3110) Photographer unknown, 1923-25 BALBOA PLAZA, DESOTO BOULVARD - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

6. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3791) Photographer unknown, 1923-25 ALHAMBRA ENTRANCE (COMMERCIAL ENTRANCE) - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

Discrimination of Clover and Citrus Honeys from Egypt According to Floral Type Using Easily Assessable Physicochemical Parameters and Discriminant Analysis: An External Validation of the Chemometric Approach.

PubMed

Karabagias, Ioannis K; Karabournioti, Sofia

2018-05-03

Twenty-two honey samples, namely clover and citrus honeys, were collected from the greater Cairo area during the harvesting year 2014⁻2015. The main purpose of the present study was to characterize the aforementioned honey types and to investigate whether the use of easily assessable physicochemical parameters, including color attributes in combination with chemometrics, could differentiate honey floral origin. Parameters taken into account were: pH, electrical conductivity, ash, free acidity, lactonic acidity, total acidity, moisture content, total sugars (degrees Brix-°Bx), total dissolved solids and their ratio to total acidity, salinity, CIELAB color parameters, along with browning index values. Results showed that all honey samples analyzed met the European quality standards set for honey and had variations in the aforementioned physicochemical parameters depending on floral origin. Application of linear discriminant analysis showed that eight physicochemical parameters, including color, could classify Egyptian honeys according to floral origin ( p < 0.05). Correct classification rate was 95.5% using the original method and 90.9% using the cross validation method. The discriminatory ability of the developed model was further validated using unknown honey samples. The overall correct classification rate was not affected. Specific physicochemical parameter analysis in combination with chemometrics has the potential to enhance the differences in floral honeys produced in a given geographical zone.

Discrimination of Clover and Citrus Honeys from Egypt According to Floral Type Using Easily Assessable Physicochemical Parameters and Discriminant Analysis: An External Validation of the Chemometric Approach

PubMed Central

Karabournioti, Sofia

2018-01-01

Twenty-two honey samples, namely clover and citrus honeys, were collected from the greater Cairo area during the harvesting year 2014–2015. The main purpose of the present study was to characterize the aforementioned honey types and to investigate whether the use of easily assessable physicochemical parameters, including color attributes in combination with chemometrics, could differentiate honey floral origin. Parameters taken into account were: pH, electrical conductivity, ash, free acidity, lactonic acidity, total acidity, moisture content, total sugars (degrees Brix-°Bx), total dissolved solids and their ratio to total acidity, salinity, CIELAB color parameters, along with browning index values. Results showed that all honey samples analyzed met the European quality standards set for honey and had variations in the aforementioned physicochemical parameters depending on floral origin. Application of linear discriminant analysis showed that eight physicochemical parameters, including color, could classify Egyptian honeys according to floral origin (p < 0.05). Correct classification rate was 95.5% using the original method and 90.9% using the cross validation method. The discriminatory ability of the developed model was further validated using unknown honey samples. The overall correct classification rate was not affected. Specific physicochemical parameter analysis in combination with chemometrics has the potential to enhance the differences in floral honeys produced in a given geographical zone. PMID:29751543

42. Photocopy of photograph (original photograph in possession of Sacramento ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Photocopy of photograph (original photograph in possession of Sacramento Archives and Museum Collection Center, Sacramento, California) Original photographer and year unknown. BEANS GROWING ON THE PHILIP S. DRIVER ESTATE LANDS IN NATOMAS DISTRICT NO. 1000. - Reclamation District 1000, Northwest Sacramento County & southwest Sutter County, bisected by State Highway No. 99, Sacramento, Sacramento County, CA

36. Photocopy of Photograph (original print located in the Twin ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. Photocopy of Photograph (original print located in the Twin Falls Library, Twin Falls, Idaho). Original Photograph, Bisbee Photo, William H. Eaton, Photographer, date unknown. COTTONWOOD FLUME SOUTH OF KIMBERLY, IDAHO. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

Human enteroviruses are not the cause of neurological impairments in children at the Korle-Bu Teaching Hospital.

PubMed

Tettey, Prudence; Badoe, Ebenezer; Adiku, Theophilus; Obodai, Eva; Odoom, John Kofi

2014-01-01

Convulsions associated with fever and acute onset of unknown aetiology with case fatalities have become a long observed medical condition at the Child Health Department of the Korle-Bu Teaching Hospital. Children admitted to the department with seizures of undetermined origin and fever has been a source of diagnostic confusion. Studies from the Asia Pacific region suggest a link with non-polio enteroviruses. The aim of the study was to investigate the association between non-polio enterovirus and acute encephalopathy causing neurological morbidity in children. One hundred and fifty cerebrospinal fluid (CSF), throat swab and serum samples were collected from participants at the Child Health Department of the Korle-Bu Teaching Hospital for virus isolation and characterization. Samples were cultured on cells and positive culture assayed by microneutralisation. Direct PCR as well as multiplex PCR were used to detect other viral agents present. Enterovirus isolation rate was approximately 0.67%. Intratypic differentiation by molecular characterization identified a poliovirus from vaccine origin. Further screening by real-time RT-PCR identified the virus as normal Sabin and not vaccine-derive poliovirus. No arbovirus was however detected. Non-polio enteroviruses and chikugunya virus were found not to be the etiologic agent responsible for the convulsion with neurologic morbidity observed in the Ghanaian children. Investigation for other viral agents is recommended.

61. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

61. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 1994. CBB 944-3190. AERIAL VIEW OF B-51 BEVATRON - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

23. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. March 26, 1953. BEV-551. OVERALL VIEW OF ION GUN. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

57. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

57. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. December 29, 1953. BEV-657. WEST TANK OPEN, CLOSE-UP. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

58. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

58. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. December 11, 1956. BEV-1206. PUMP ROOM WITH W. CHUPP IN BACKGROUND - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

8. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. July 2, 1953. BEV-574. QUADRANT POLE TIP INSTALLATION. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

12. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. February 5, 1954. BEV-681. GENERATOR ROOM FOR BEVATRON MAGNET. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

17. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. October 20, 1958. BEV-1654. OVERALL VIEW WITH PROTON INJECTOR. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

51. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

51. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 22, 1950. BEV-248. INTERIOR OF BEVATRON BUILDING. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

3. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. November 22, 1963. BEV-3470 INTERNAL BEAM EXPERIMENT DIAGRAM. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

16. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. December 29, 1953. BEV-654. INJECTOR, INJECTOR TANK-WIDE ANGLE; MARIO CAROTTA. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

55. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

55. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. November 29, 1950. BEV-359. GENERATOR ROOM, LOOKING SOUTH, B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

45. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 28, 1954. BEV-733. MAIN CONTROL ROOM; BOB RICHTER. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

54. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

54. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. September 29, 1950. BEV-328. NORTH SIDE OF BEVATRON BUILDING. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

2. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. November 22, 1963. BEV-3469 EXTERNAL BEAM EXPERIMENT DIAGRAM. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

20. Photocopy of negative (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Photocopy of negative (original in possession of WACC), photographer unknown, c.1920's BOY WITH DEER STANDING IN EAST YARD OF MAIN HOUSE WITH WELL AND SCREENED PORCH PICTURED IN LEFT BACKGROUND - Faraway Ranch, Willcox, Cochise County, AZ

41. Photocopy of negative (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Photocopy of negative (original in possession of WACC), photographer unknown, 1935 NEIL ERICKSON IN FRONT OF 'GARFIELD' FIREPLACE/CHIMNEY (NOTE: REAR PORCH IS ENCLOSED) - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

36. Photocopy of photograph (original in possession of Chiricahua National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. Photocopy of photograph (original in possession of Chiricahua National Monument), photographer unknown, c.1915 EMMA ERICKSON AND MRS. COLLINS ON BALCONY OF RANCH HOUSE - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

35. Photocopy of negative (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. Photocopy of negative (original in possession of WACC), photographer unknown, c.1915 FARAWAY RANCH AS COMPLETED WITH ADOBE BRICK WALLS AND WOOD SHINGLE ROOF - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

1. Photocopy of measured drawing (original delineated by the Royal ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of measured drawing (original delineated by the Royal Danish Academy of Fine Arts (Kunstakademiets), Copenhagen, Denmark, 1961) Photographer and date of photograph unknown HOSPITALSGADE (FRONT) ELEVATION - Hospitalsgade 23 (House), 23 Hospital Street, Christiansted, St. Croix, VI

14. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, CK 109) Photographer unknown, 1923-25 ALHANBRA CIRCLE, VIEW TOWARDS GRANADA PLAZA - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

6. Photo copy of photograph, (original in Forest Service Office, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photo copy of photograph, (original in Forest Service Office, Elkins, WV, photo #246860), photographer unknown, ca. 1935. EQUIPMENT DETAIL, SEED WING REMOVER. - Parsons Nursery, Seed Extractor Building, South side of U.S. Route 219, Parsons, Tucker County, WV

9. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer unknown, ca. 1903-04. VIEW OF WORKERS AND BRIDGE UNDER CONSTRUCTION - Union Pacific Railroad Bridge, Spanning Santa Anna River, west of Riverside, Riverside, Riverside County, CA

30. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer and date unknown. VIEW OF SANTA FE RAILROAD TRACKS AND PACHAPPA AVENUE (COMMERCE STREET) LOOKING NORTH - California Citrus Heritage Recording Project, Riverside, Riverside County, CA

41. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. August 29, 1949. BEV-101. BEVATRON AREA LOOKING SOUTHEAST. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

15. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3872) Photographer unknown, 1923-25 VIEW OF COUNTRY CLUB PRADO BOULEVARD - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

5. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3292) Photographer unknown, 1923-25 AERIAL VIEW OF CORAL GABLES BUSINESS SECTION - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

13. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3327) Photographer unknown, 1923-25 LE JEUNE PLAZA, VIEW FROM CORAL WAY - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

8. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3829) Photographer unknown, 1923-25 SEGOVIA PLAZA AT NORTH GREENWAY DRIVE - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

Registration of 'Hidden Valley' meadow fescue

USDA-ARS?s Scientific Manuscript database

'Hidden Valley' (Reg. No. CV-xxxx, PI xxxxxx) meadow fescue [Schedonorus pratensis (Huds.) P. Beauv.; syn. Festuca pratensis Huds.; syn. Lolium pratense (Huds.) Darbysh.] is a synthetic population originating from 561 parental genotypes. The original germplasm is of unknown central or northern Europ...

44. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Photocopy of a photograph (original print in the collection of the Claremont Historical Society) No date, photographer unknown HORSE TEAM HAULING A T-CONNECTION FOR A PENSTOCK. - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

13. Photocopy of photograph (original in Documents Collection, College of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph (original in Documents Collection, College of Environmental Design, University of California, Berkeley, CA) Circa 1910, photographer unknown VIEW LOOKING NORTHEAST - Howard B. Gates House, 62 South Thirteenth Street, San Jose, Santa Clara County, CA

17. Photocopy of original USRS photograph (from original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of original USRS photograph (from original print in the Umatilla Project History 1920, on file at National Archives, Rocky Mountain Region, Denver, Colorado) Photographer unknown, ca. 1920. Project office and employees - reading from left to right: Una H. Keck, Geo. C. Patterson, H.M. Schilling, Maurice D. Scroggs, Carl M. Voyen, Chas. Taylor, C.D. Porter - Former Umatilla Project Headquarters Buildings, Office, Hermiston, Umatilla County, OR

Fabrication and thermophysical property characterization of UN/U 3Si 2 composite fuel forms

DOE PAGES

White, Joshua Taylor; Travis, Austin William; Dunwoody, John Tyler; ...

2017-09-21

High uranium density composite fuels composed of UN and U 3Si 2 have been fabricated using a liquid phase sintering route at temperatures between 1873 K and 1973 K and spanning compositions of 10 vol% to 40 vol% U 3Si 2. Microstructural analysis and phase characterization revealed the formation of an U-Si-N phase of unknown structure. Microcracking was observed in the U-Si portion of the composite microstructure that likely originates from the mismatched coefficient of thermal expansion between the UN and U 3Si 2 leading to stresses on heating and cooling of the composite. Thermal expansion coefficient, thermal diffusivity, andmore » thermal conductivity were characterized for each of the compositions as a function of temperature to 1673 K. Hysteresis is observed in the thermal diffusivity for the 20 vol% through 40 vol% specimens between room temperature and 1273 K, which is attributed to the microcracking in the U-Si phase. Thermal conductivity of the composites was modeled using the MOOSE framework based on the collected microstructure data. In conclusion, the impact of irradiation on thermal conductivity was also simulated for this class of composite materials.« less

Fabrication and thermophysical property characterization of UN/U 3Si 2 composite fuel forms

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Joshua Taylor; Travis, Austin William; Dunwoody, John Tyler

High uranium density composite fuels composed of UN and U 3Si 2 have been fabricated using a liquid phase sintering route at temperatures between 1873 K and 1973 K and spanning compositions of 10 vol% to 40 vol% U 3Si 2. Microstructural analysis and phase characterization revealed the formation of an U-Si-N phase of unknown structure. Microcracking was observed in the U-Si portion of the composite microstructure that likely originates from the mismatched coefficient of thermal expansion between the UN and U 3Si 2 leading to stresses on heating and cooling of the composite. Thermal expansion coefficient, thermal diffusivity, andmore » thermal conductivity were characterized for each of the compositions as a function of temperature to 1673 K. Hysteresis is observed in the thermal diffusivity for the 20 vol% through 40 vol% specimens between room temperature and 1273 K, which is attributed to the microcracking in the U-Si phase. Thermal conductivity of the composites was modeled using the MOOSE framework based on the collected microstructure data. In conclusion, the impact of irradiation on thermal conductivity was also simulated for this class of composite materials.« less

40. Photocopy of building model photograph, ca., 1974, photographer unknown. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Photocopy of building model photograph, ca., 1974, photographer unknown. Original photograph property of United States Air Force, 21" Space Command. CAPE COD AIR STATION PAVE PAWS FACILITY MODEL - ELEVATION SHOWING FLOOR AND EQUIPMENT LAYOUT. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

39. Photocopy of building model photograph, ca. 1974, photographer unknown. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Photocopy of building model photograph, ca. 1974, photographer unknown. Original photograph property of United States Air Force, 21" Space Command. CAPE COD AIR STATION PAVE PAWS FACILITY MODEL - SHOWING "A" AND "B" FACES. - Cape Cod Air Station, Technical Facility-Scanner Building & Power Plant, Massachusetts Military Reservation, Sandwich, Barnstable County, MA

6. Photographic copy of historic photograph (date and photograph unknown) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photographic copy of historic photograph (date and photograph unknown) of upper dam showing retaining walls (original in possession of United States Department of Agriculture-Forest Service-Allegheny National Forest). VIEW WEST - Loleta Recreation Area, Upper Dam, 6 miles Southeast of interesection of State Route 24041 & State Route 66, Loleta, Elk County, PA

The role of invasive and non-invasive procedures in diagnosing fever of unknown origin.

PubMed

Mete, Bilgul; Vanli, Ersin; Yemisen, Mucahit; Balkan, Ilker Inanc; Dagtekin, Hilal; Ozaras, Resat; Saltoglu, Nese; Mert, Ali; Ozturk, Recep; Tabak, Fehmi

2012-01-01

The etiology of fever of unknown origin has changed because of the recent advances in and widespread use of invasive and non-invasive diagnostic tools. However, undiagnosed patients still constitute a significant number. To determine the etiological distribution and role of non-invasive and invasive diagnostic tools in the diagnosis of fever of unknown origin. One hundred patients who were hospitalized between June 2001 and 2009 with a fever of unknown origin were included in this study. Clinical and laboratory data were collected from the patients' medical records retrospectively. Fifty three percent of the patients were male, with a mean age of 45 years. The etiology of fever was determined to be infectious diseases in 26, collagen vascular diseases in 38, neoplastic diseases in 14, miscellaneous in 2 and undiagnosed in 20 patients. When the etiologic distribution was analyzed over time, it was noted that the rate of infectious diseases decreased, whereas the rate of rheumatological and undiagnosed diseases relatively increased because of the advances in imaging and microbiological studies. Seventy patients had a definitive diagnosis, whereas 10 patients had a possible diagnosis. The diagnoses were established based on clinical features and non-invasive tests for 61% of the patients and diagnostic benefit was obtained for 49% of the patients undergoing invasive tests. Biopsy procedures contributed a rate of 42% to diagnoses in patients who received biopsies. Clinical features (such as detailed medical history-taking and physical examination) may contribute to diagnoses, particularly in cases of collagen vascular diseases. Imaging studies exhibit certain pathologies that guide invasive studies. Biopsy procedures contribute greatly to diagnoses, particularly for malignancies and infectious diseases that are not diagnosed by non-invasive procedures.

7. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. November 29, 1950. BEV-360. GENERAL VIEW, MAGNET ROOM, LOOKING SOUTHWEST. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

42. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. September 29, 1949. BEV-132. LOOKING NORTHWEST AT INITIAL STAGES OF CONSTRUCTION. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

35. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 27, 1960. BEV-2050. CLYDE WIEGAND; ANTI-PROTON SET-UP. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

48. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. February 10, 1960. BEV-2003. COAXIAL, MAIN CONTROL ROOM CONSOLE MODIFICATIONS. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

52. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. June 28, 1950. BEV-267. INTERIOR OF BEVATRON BUILDING LOOKING WEST. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

32. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

32. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. October 6, 1955. BEV-937. ANTI-PROTON SET-UP, EXTERIOR VIEW. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

31. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. October 6, 1955. BEV-933. ANTI-PROTON SET-UP, INTERIOR VIEW. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

11. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. December 17, 1952. BEV-517. MOVING CURVE TANK INTO MAGNET FOR STORAGE. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

53. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

53. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. June 28, 1950. BEV-268. EXTERIOR OF SOUTHWEST CORNER OF BEVATRON BUILDING. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

10. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. November 11, 1950. BEV-336. MAGNET CORE SHOWING FOUNDATION AND SUPPORTS. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

48. Photocopy of photograph (original print in possession of Historic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. Photocopy of photograph (original print in possession of Historic Bethlehem, Inc., Bethlehem, PA) photographer unknown, 1922. Concrete handling method along the main street ramp - Hill to Hill Bridge, Spans Lehigh River at State Route 378, Bethlehem, Northampton County, PA

7. Photograph is copy of historic photo (original print located ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photograph is copy of historic photo (original print located in Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Ogden Arsenal, Primer Loading Building for 37mm Shell Loading, 7726 North Carolina Way, Layton, Davis County, UT

1. Photocopy of photograph (original print #17 located in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of photograph (original print #17 - located in Pope & Talbot Archives. Port Gamble, WA). Unknown Photographer, September 1906. View of St. Paul's Episcopal Church, facing southwest from Rainier Avenue. - St. Paul's Episcopal Church, Rainier Avenue, Port Gamble, Kitsap County, WA

9. Photocopy of photograph (original photograph in possession of Coronado ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original photograph in possession of Coronado Historical Association). Photographer Unknown, circa 1922. HEILMAN VILLAS FROM CORNER OF ORANGE AVENUE AND SEVENTH STREET - Heilman Villas, 706-720 Orange Avenue & 1060-1090 Seventh Street, Coronado, San Diego County, CA

10. Photocopy of Photograph (original print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photocopy of Photograph (original print in the Coral Gables Public Library, Fishbaugh Collection, M 3109) Photographer unknown, 1923-25 COLUMBUS PLAZA, COLUMBUS STREET AND INDIAN MOUNTAIN TRAIL - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

22. Photocopy of photograph (original print in files of Theatre ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photocopy of photograph (original print in files of Theatre Historical Society, P.O. Box 101, Notre Dame, IN 46556) Photographer unknown 1938 TREMONT STREET ANNEX, LOOKING SOUTHEAST - B. F. Keith Memorial Theatre, 539 Washington Street, Boston, Suffolk County, MA

Photocopy of original blackandwhite silver gelatin print, AERIAL VIEW OF ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of original black-and-white silver gelatin print, AERIAL VIEW OF FEDERAL TRIANGLE, IRS BUILDING EAST SIDE OF THE OLD POST OFFICE BUILDING, 1936, photographer unknown - Internal Revenue Service Headquarters Building, 1111 Constitution Avenue Northwest, Washington, District of Columbia, DC

Efficacy of function specific 3D-motifs in enzyme classification according to their EC-numbers.

PubMed

Rahimi, Amir; Madadkar-Sobhani, Armin; Touserkani, Rouzbeh; Goliaei, Bahram

2013-11-07

Due to the increasing number of protein structures with unknown function originated from structural genomics projects, protein function prediction has become an important subject in bioinformatics. Among diverse function prediction methods, exploring known 3D-motifs, which are associated with functional elements in unknown protein structures is one of the most biologically meaningful methods. Homologous enzymes inherit such motifs in their active sites from common ancestors. However, slight differences in the properties of these motifs, results in variation in the reactions and substrates of the enzymes. In this study, we examined the possibility of discriminating highly related active site patterns according to their EC-numbers by 3D-motifs. For each EC-number, the spatial arrangement of an active site, which has minimum average distance to other active sites with the same function, was selected as a representative 3D-motif. In order to characterize the motifs, various points in active site elements were tested. The results demonstrated the possibility of predicting full EC-number of enzymes by 3D-motifs. However, the discriminating power of 3D-motifs varies among different enzyme families and depends on selecting the appropriate points and features. © 2013 Elsevier Ltd. All rights reserved.

Efficacy of intravenous immunoglobulin in chronic idiopathic pericarditis: report of four cases.

PubMed

Peterlana, D; Puccetti, A; Simeoni, S; Tinazzi, E; Corrocher, R; Lunardi, C

2005-02-01

Human intravenous immunoglobulins (hIVIgs) are used in two broad categories of diseases: immunodeficiency and autoimmunity. Among the immune-mediated diseases hIVIgs are of benefit in idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and dermatomyositis. Chronic idiopathic pericarditis (CIP) is a chronic disease of unknown origin characterized by recurrent episodes of pericardial inflammation. The cause of the recurrence is unknown, although in some cases it may be traced to a viral infection and to the presence of antimyocardial antibodies. Since a viral infection can induce an autoimmune process through a mechanism of molecular mimicry, and since the optimal therapy for prevention of the recurrences has not been established, we reasoned that treatment with hIVIgs could be beneficial in our patients unresponsive to previous immunosuppressive therapies. We describe four patients affected by CIP treated with monthly high-dose hIVIgs (0.4 g/kg daily for 5 consecutive days) for five times followed by administration every 2 months. Three of the four patients could permanently discontinue steroid therapy and are still in remission after years of follow-up. Our experience suggests that hIVIgs therapy may be a useful and safe treatment for CIP in steroid-dependent patients.

Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells.

PubMed

Lv, Lei; Zhang, Tianwei; Yi, Qiyi; Huang, Yun; Wang, Zheng; Hou, Heli; Zhang, Huan; Zheng, Wei; Hao, Qiaomei; Guo, Zongyou; Cooke, Howard J; Shi, Qinghua

2012-08-01

Most ovarian cancers originate from the ovarian surface epithelium and are characterized by aneuploid karyotypes. Aneuploidy, a consequence of chromosome instability, is an early event during the development of ovarian cancers. However, how aneuploid cells are evolved from normal diploid cells in ovarian cancers remains unknown. In the present study, cytogenetic analyses of a mouse syngeneic ovarian cancer model revealed that diploid mouse ovarian surface epithelial cells (MOSECs) experienced an intermediate tetraploid cell stage, before evolving to aneuploid (mainly near-tetraploid) cells. Using long-term live-cell imaging followed by fluorescence in situ hybridization (FISH), we demonstrated that tetraploid cells originally arose from cytokinesis failure of bipolar mitosis in diploid cells, and gave rise to aneuploid cells through chromosome mis-segregation during both bipolar and multipolar mitoses. Injection of the late passage aneuploid MOSECs resulted in tumor formation in C57BL/6 mice. Therefore, we reveal a pathway for the evolution of diploid to aneuploid MOSECs and elucidate a mechanism for the development of near-tetraploid ovarian cancer cells.

Online professionalism: A synthetic review.

PubMed

Chretien, Katherine C; Tuck, Matthew G

2015-04-01

The rise of social media has increased connectivity and blurred personal and professional boundaries, bringing new challenges for medical professionalism. Whether traditional professionalism principles apply to the online social media space remains unknown. The purpose of this synthetic literature review was to characterize the original peer-reviewed research studies published between 1 January 2000-1 November 2014 on online professionalism, to assess methodologies and approaches used, and to provide insights to guide future studies in this area. The investigators searched three databases and performed manual searches of bibliographies to identify the 32 studies included. Most studies originated in the USA. Cross-sectional surveys and analyses of publicly available online content were the most common methodologies employed. Studies covered the general areas of use and privacy, assessment of unprofessional online behaviours, consensus-gathering of what constitutes unprofessional or inappropriate online behaviours, and education and policies. Studies were of variable quality; only around half of survey studies had response rates of 50% or greater. Medical trainees were the most common population studied. Future directions for research include public perspectives of online professionalism, impact on patient trust, and how to use social media productively as medical professionals.

What lysosomes actually tell us about Parkinson's disease?

PubMed

Bourdenx, Mathieu; Dehay, Benjamin

2016-12-01

Parkinson's disease is a common neurodegenerative disorder of unknown origin mainly characterized by the loss of neuromelanin-containing dopaminergic neurons in the substantia nigra pars compacta and the presence of intraneuronal proteinaceous inclusions called Lewy bodies. Lysosomes are dynamic organelles that degrade, in a controlled manner, cellular components delivered via the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Increasing amounts of evidence suggest a central role of lysosomal impairment in PD aetiology. This review provides an update on how genetic evidence support this connection and highlights how the neuropathologic and mechanistic evidence might relate to the disease process in sporadic forms of Parkinson's disease. Finally, we discuss the influence of ageing on lysosomal impairment and PD aetiology and therapeutic strategies targeting lysosomal function. Copyright © 2016 Elsevier B.V. All rights reserved.

Fine-tuned broad binding capability of human lipocalin-type prostaglandin D synthase for various small lipophilic ligands.

PubMed

Kume, Satoshi; Lee, Young-Ho; Nakatsuji, Masatoshi; Teraoka, Yoshiaki; Yamaguchi, Keisuke; Goto, Yuji; Inui, Takashi

2014-03-18

The hydrophobic cavity of lipocalin-type prostaglandin D synthase (L-PGDS) has been suggested to accommodate various lipophilic ligands through hydrophobic effects, but its energetic origin remains unknown. We characterized 18 buffer-independent binding systems between human L-PGDS and lipophilic ligands using isothermal titration calorimetry. Although the classical hydrophobic effect was mostly detected, all complex formations were driven by favorable enthalpic gains. Gibbs energy changes strongly correlated with the number of hydrogen bond acceptors of ligand. Thus, the broad binding capability of L-PGDS for ligands should be viewed as hydrophilic interactions delicately tuned by enthalpy-entropy compensation using combined effects of hydrophilic and hydrophobic interactions. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Esophageal achalasia: current diagnosis and treatment.

PubMed

Schlottmann, Francisco; Patti, Marco G

2018-05-27

Esophageal achalasia is a primary esophageal motility disorder of unknown origin, characterized by lack of peristalsis and by incomplete or absent relaxation of the lower esophageal sphincter in response to swallowing. The goal of treatment is to eliminate the functional obstruction at the level of the gastroesophageal junction Areas covered: This comprehensive review will evaluate the current literature, illustrating the diagnostic evaluation and providing an evidence-based treatment algorithm for this disease Expert commentary: Today we have three very effective therapeutic modalities to treat patients with achalasia - pneumatic dilatation, per-oral endoscopic myotomy and laparoscopic Heller myotomy with fundoplication. Treatment should be tailored to the individual patient, in centers where a multidisciplinary approach is available. Esophageal resection should be considered as a last resort for patients who have failed prior therapeutic attempts.

Targeting CD4+ T cells for the treatment of sarcoidosis: a promising strategy?

PubMed Central

Celada, Lindsay J; Drake, Wonder P

2017-01-01

Sarcoidois is an inflammatory disease of unknown origin characterized by the abnormal accumulation of noncaseating granulomas at sites of disease activity in multiple organs throughout the body with a predilection for the lungs. Because the exact trigger that leads to disease activity is still under investigation, current treatment options are contingent on the organ or organs affected. Corticosteroids are the therapy of choice, but antimalarials and TNF-α antagonists are also commonly prescribed. Recent findings provide evidence for the use of CD20 B-cell-depleting therapy as an alternative method of choice. However, because sarcoidosis is predominantly a T-helper cell-driven disorder, an overwhelming amount of compelling evidence exists for the use of CD4+ T-cell targeted therapy. PMID:25572480

Anomalous aortic origin of a coronary artery: toward a standardized approach.

PubMed

Mery, Carlos M; Lawrence, Silvana M; Krishnamurthy, Rajesh; Sexson-Tejtel, S Kristen; Carberry, Kathleen E; McKenzie, E Dean; Fraser, Charles D

2014-01-01

Anomalous aortic origin of a coronary artery (AAOCA) is a congenital abnormality of the origin or course of a coronary artery that arises from the aorta. It is the second most common cause of sudden cardiac death in young athletes. Its exact prevalence, the pathophysiological mechanisms that cause sudden cardiac death, the actual risk of death for the different types of AAOCA, the optimal way to evaluate these patients, and whether any treatment strategies decrease the risk of sudden cardiac death in patients diagnosed with AAOCA are unknown. This article analyzes what is currently known and unknown about this disease. It also describes the creation of a dedicated multidisciplinary coronary anomalies program and the development of a framework in an initial attempt to standardize the evaluation and management of these patients. Copyright © 2014 Elsevier Inc. All rights reserved.

28. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 1, 1959. Bubble Chamber 722. BUBBLE CHAMBER, WIDE-ANGLE INTERIOR VIEW OF BUILDING 59 - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

33. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 10, 1958. BEV-1515. ANTI-PROTON SET-UP; BRUCE CORK, GLENN LAMBERTSON. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

Photocopy of a photograph (original taken for the Edison Co.) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of a photograph (original taken for the Edison Co.) Unknown, Photographer, 1939 AERIAL VIEW (SOUTH) SHOWING NORTH ELEVATION AND OTHER LABORATORY BUILDINGS AROUND THE COURTYARD - Thomas A. Edison Laboratories, Machine Shop & Library, Main Street & Lakeside Avenue, West Orange, Essex County, NJ

9. Photocopy of photograph (original print in possession of WACC), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original print in possession of WACC), photographer unknown, c.1900's NEIL ERICKSON ON LEDGE OVERLOOKING BONITA CANYON WITH STAFFORD CABIN IN FOREGROUND AND ERICKSON HOUSE IN DISTANCE (BOARD AND BATTEN PERIOD) - Faraway Ranch, Willcox, Cochise County, AZ

11. Photocopy of Photograph (original Print in the Coral Gables ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of Photograph (original Print in the Coral Gables Public Library, Fishbaugh Collection, M 3809) Photographer unknown, 1923-25 PONCE DE LEON PLAZA, FROM CORAL WAY AND GRANADA BOULEVARD - Coral Gables (Entrances, Streets, Gates, & Squares), Coral Gables, Miami-Dade County, FL

59. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

59. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. April 25, 1957. BEV-1311. VACUUM SNOUT IN NORTH TARGET AREA; BOB RICHTER. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

Isolated muscular sarcoidosis causing fever of unknown origin: The value of gallium-67 imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, N.; Krasnow, A.; Sebastian, J.L.

1991-02-01

An unusual case of a patient with a long-standing fever of unknown origin (FUO) is presented whose gallium-67 ({sup 67}Ga) images revealed increased activity only in the calf muscles bilaterally. Other imaging modalities also failed to show chest or other abnormal findings. Subsequent biopsy of the right gastrocnemius muscle revealed noncaseating granulomas consistent with the diagnosis of sarcoidosis. When using {sup 67}Ga to evaluate a patient with a FUO, imaging of the extremities should always be included. Also, when abnormal Ga-67 uptake is present in the extremities, sarcoidosis should be included in the differential diagnosis.

Investigating the Geological History of Asteroid 101955 Bennu Through Remote Sensing and Returned Sample Analyses

NASA Technical Reports Server (NTRS)

Messenger, S.; Connolly, H. C., Jr.; Lauretta, D. S.; Bottke, W. F.

2014-01-01

The NASA New Frontiers Mission OSRIS-REx will return surface regolith samples from near-Earth asteroid 101955 Bennu in September 2023. This target is classified as a B-type asteroid and is spectrally similar to CI and CM chondrite meteorites [1]. The returned samples are thus expected to contain primitive ancient Solar System materials that formed in planetary, nebular, interstellar, and circumstellar environments. Laboratory studies of primitive astromaterials have yielded detailed constraints on the origins, properties, and evolutionary histories of a wide range of Solar System bodies. Yet, the parent bodies of meteorites and cosmic dust are generally unknown, genetic and evolutionary relationships among asteroids and comets are unsettled, and links between laboratory and remote observations remain tenuous. The OSIRIS-REx mission will offer the opportunity to coordinate detailed laboratory analyses of asteroidal materials with known and well characterized geological context from which the samples originated. A primary goal of the OSIRIS-REx mission will be to provide detailed constraints on the origin and geological and dynamical history of Bennu through coordinated analytical studies of the returned samples. These microanalytical studies will be placed in geological context through an extensive orbital remote sensing campaign that will characterize the global geological features and chemical diversity of Bennu. The first views of the asteroid surface and of the returned samples will undoubtedly bring remarkable surprises. However, a wealth of laboratory studies of meteorites and spacecraft encounters with primitive bodies provides a useful framework to formulate priority scientific questions and effective analytical approaches well before the samples are returned. Here we summarize our approach to unraveling the geological history of Bennu through returned sample analyses.

Carbonaceous aerosol characterization in the Amazon basin, Brazil: novel dicarboxylic acids and related compounds

NASA Astrophysics Data System (ADS)

Kubátová, Alena; Vermeylen, Reinhilde; Claeys, Magda; Cafmeyer, Jan; Maenhaut, Willy; Roberts, Greg; Artaxo, Paulo

High-resolution capillary gas chromatography (GC) and GC/mass spectrometry (MS) were employed for the quantitative determination of dichloromethane-extractable organic compounds in total and size-fractionated aerosol samples which were collected in the Amazon basin, Brazil, during the wet season, as part of the LBA-CLAIRE-98 experiment. Special emphasis was placed on the characterization and identification of several novel unknown dicarboxylic acids and related oxidative degradation products. This class of acidic products was enriched in the fine size fraction, suggesting that they were secondary organic aerosol products formed by gas-to-particle conversion. Some of the unknowns contributed more to the class of dicarboxylic acids than the major known compound, nonadioic acid (azelaic acid). The same unknowns were also observed in urban aerosol samples collected on hot summer days in Gent, Belgium. For the characterization and structure elucidation of the unknowns, various types of derivatizations and fractionation by solid-phase extraction were employed in combination with GC/MS. Four unknowns were identified. The most abundant were two derivatives of glutaric acid, 3-isopropyl pentanedioic acid and 3-acetyl pentanedioic acid. The other two identified unknowns were another oxo homologue, 3-acetyl hexanedioic acid, and, interestingly, 3-carboxy heptanedioic acid. To our knowledge, the occurrence of these four compounds in atmospheric aerosols has not yet been reported. The biogenic precursors of the novel identified compounds could not be pinpointed, but most likely include monoterpenes and fatty acids.

Terrorist Group Profiles

DTIC Science & Technology

1988-11-01

Formed 1975. Estimated Membership Unknown. Headquarters Unknown. Area of Operations Worldwide. Leadership ASALA-RM: Monte Melkonian. ASALA-M: Hagop...release. Black Sea are. Stan ulSOVIEIT UNION ®ANKARA ~ Ararat TURKEY Moditerroneen Sea LES- BEIRUT ’ . Historic area claimed by Armenian terrorists...Lima, Peru. - Leadership Ernesto Montes Aliaga (AKA Raul Perez). Other Names Movimiento Revolucionario Tupac Amaru (original language). Armed members of

29. Photocopy of photograph. VIEW, LOOKING NORTHEAST, OF NORTHEAST SECTION ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Photocopy of photograph. VIEW, LOOKING NORTHEAST, OF NORTHEAST SECTION OF THE STRUCTURE, SHOWING ORIGINAL WOOD DECK, RAILING AND EARLY 1930'S PACKARD AUTOMOBILE IN BACKGROUND. Photographer unknown, date unknown. (Print in possession of the Washington County Highway Department). - Hegeman-Hill Street Bridge, Spanning Batten Kill, .65 mile West of Greenwich, Easton, Washington County, NY

7. Photocopy of photograph, date unknown. VIEW OF WEST HIGH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph, date unknown. VIEW OF WEST HIGH STREET BRIDGE OVER SOUTH BRANCH OF FRENCH CREEK, WITH PENN RAILROAD BRIDGE IN BACKGROUND. (Original in Union City Historical Museum.) 8'x10' enlargement from 4'x5' negative. - Bridge Street Bridge, Spanning Little French Creek at Bridge Street, Union City, Erie County, PA

The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis

PubMed Central

Delaney, Sean P.; Julian, Lisa M.; Stanford, William L.

2014-01-01

Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease, best characterized by the formation of proliferative nodules that express smooth muscle and melanocytic antigens within the lung parenchyma, leading to progressive destruction of lung tissue and function. The pathological basis of LAM is associated with Tuberous Sclerosis Complex (TSC), a multi-system disorder marked by low-grade tumors in the brain, kidneys, heart, eyes, lung and skin, arising from inherited or spontaneous germ-line mutations in either of the TSC1 or TSC2 genes. LAM can develop either in a patient with TSC (TSC-LAM) or spontaneously (S-LAM), and it is clear that the majority of LAM lesions of both forms are characterized by an inactivating mutation in either TSC1 or TSC2, as in TSC. Despite this genetic commonality, there is considerable heterogeneity in the tumor spectrum of TSC and LAM patients, the basis for which is currently unknown. There is extensive clinical evidence to suggest that the cell of origin for LAM, as well as many of the TSC-associated tumors, is a neural crest cell, a highly migratory cell type with extensive multi-lineage potential. Here we explore the hypothesis that the types of tumors that develop and the tissues that are affected in TSC and LAM are dictated by the developmental timing of TSC gene mutations, which determines the identities of the affected cell types and the size of downstream populations that acquire a mutation. We further discuss the evidence to support a neural crest origin for LAM and TSC tumors, and propose approaches for generating humanized models of TSC and LAM that will allow cell of origin theories to be experimentally tested. Identifying the cell of origin and developing appropriate humanized models is necessary to truly understand LAM and TSC pathology and to establish effective and long-lasting therapeutic approaches for these patients. PMID:25505789

7. Photocopy of photograph (original in possession of NYC Economic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph (original in possession of NYC Economic Development Corp.) Photographer unknown, circa 1983) OVERALL VIEW OF THE BROOKLYN ARMY TERMINAL, LOOKING NORTHEAST - Wood's Grist Mill, South bank of Indian River, 1 mile east of Breached Mill Dam, Antwerp, Jefferson County, NY

9. Photocopy of photograph (original print at Riverside Library, Local ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original print at Riverside Library, Local History Collection), photographer unknown, October 1916. FORMER 'VICTORIA BRIDGE' (HOWE DECK TRUSS SUPPORTED BY TRESTLE) LOOKING SOUTHWEST, SHOWING STREETCAR AND THATCH-ROOFED, CANTILEVERED PEDESTRIAN PLATFORM - Victoria Bridge, Spanning Tequesquite Arroyo, Riverside, Riverside County, CA

36. Photographic copy of historic photo, c1915 (original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. Photographic copy of historic photo, c1915 (original print in Still Photo Branch of the National Archives, RG-155-JC, Washington, DC; photographer unknown). VIEW OF NORTH SIDE OF BOISE PROJECT OFFICE. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

20. Photo copy of photograph, (original owned by John King, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Photo copy of photograph, (original owned by John King, Berea, KY), photographer unknown, ca. 1935. VIEW SOUTH, CCC CAMP PARSONS IN BACKGROUND, BLACKSMITH SHOP ON LEFT, TRUCK STORAGE GARAGE IN FOREGROUND. - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

11. Photocopy of photograph (original copy in Edison collection). Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph (original copy in Edison collection). Photographer and date unknown, although photo taken prior to 1930 reconstruction of Project flumes. VIEW OF ORIGINAL SOUTH FORK OF THE TULE RIVER MIDDLE FORK "BOX" WOOD FLUME BRANCH SHOWING NORTH FORK OF TULE RIVER MIDDLE FORK CROSSING. VIEW TO NORTHWEST. - Tule River Hydroelectric Project, Water Conveyance System, Middle Fork Tule River, Springville, Tulare County, CA

Evolution and Structural Organization of the C Proteins of Paramyxovirinae

PubMed Central

Karlin, David G.

2014-01-01

The phosphoprotein (P) gene of most Paramyxovirinae encodes several proteins in overlapping frames: P and V, which share a common N-terminus (PNT), and C, which overlaps PNT. Overlapping genes are of particular interest because they encode proteins originated de novo, some of which have unknown structural folds, challenging the notion that nature utilizes only a limited, well-mapped area of fold space. The C proteins cluster in three groups, comprising measles, Nipah, and Sendai virus. We predicted that all C proteins have a similar organization: a variable, disordered N-terminus and a conserved, α-helical C-terminus. We confirmed this predicted organization by biophysically characterizing recombinant C proteins from Tupaia paramyxovirus (measles group) and human parainfluenza virus 1 (Sendai group). We also found that the C of the measles and Nipah groups have statistically significant sequence similarity, indicating a common origin. Although the C of the Sendai group lack sequence similarity with them, we speculate that they also have a common origin, given their similar genomic location and structural organization. Since C is dispensable for viral replication, unlike PNT, we hypothesize that C may have originated de novo by overprinting PNT in the ancestor of Paramyxovirinae. Intriguingly, in measles virus and Nipah virus, PNT encodes STAT1-binding sites that overlap different regions of the C-terminus of C, indicating they have probably originated independently. This arrangement, in which the same genetic region encodes simultaneously a crucial functional motif (a STAT1-binding site) and a highly constrained region (the C-terminus of C), seems paradoxical, since it should severely reduce the ability of the virus to adapt. The fact that it originated twice suggests that it must be balanced by an evolutionary advantage, perhaps from reducing the size of the genetic region vulnerable to mutations. PMID:24587180

Ga-68 DOTANOC PET/CT imaging in detection of primary site in patients with metastatic neuroendocrine tumours of unknown origin and its impact on clinical decision making: experience from a tertiary care centre in India

PubMed Central

Pankaj, Promila; Verma, Ritu; Jain, Anjali; Belho, Ethel S.; Mahajan, Harsh

2016-01-01

Background Neuroendocrine tumours (NETs) are rare, heterogeneous group of tumours which usually originate from small, occult primary sites and are characterized by over-expression of somatostatin receptors (SSTRs). Positron emission tomography/computed tomography (PET/CT) using Ga-68-labeled-somatostatin-analogues have shown superiority over other modalities for imaging of NETs. The objective of the study was to retrospectively evaluate the efficacy of Ga-68 DOTANOC PET/CT imaging in detecting the primary site in patients with metastatic NETs of unknown origin and its impact on clinical decision making in such patients. Methods Between December 2011 and September 2014, a total of 263 patients underwent Ga-68 DOTANOC PET/CT study in our department for various indications. Out of them, 68 patients (45 males, 23 females; mean age, 54.9±10.7 years; range, 31–78 years) with histopathologically proven metastatic NETs and unknown primary site (CUP-NET) on conventional imaging, who underwent Ga-68 DOTANOC PET/CT scan as part of their clinical work-up were included for analyses. Histopathology (wherever available) and/or follow-up imaging were taken as reference standard. Quantitative estimation of SSTR expression in the form of maximal standardized uptake value (SUVmax) of detected primary and metastatic sites was calculated. Follow-up data of individual patients was collected through careful survey of hospital medical records and telephonic interviews. Results Maximum patients presented to our department with hepatic metastasis (50 out of 68 patients) and grade I NETs (>50%). Ga-68 DOTANOC PET/CT scan identified primary sites in 40 out of these 68 patients i.e., in approximately 59% patients. Identified primary sites were: small intestine [19], rectum [8], pancreas [7], stomach [4], lung [1] and one each in rare sites in kidney and prostate. In one patient, 2 primary sites were identified (one each in stomach and duodenum). Mean SUVmax of the detected primary sites was 25.1±18.0 (median: 16.25; range, 2.1–150). Significant positive correlation was found between SUVmax of detected primary site and SUVmax of the histopathologically proven sites of metastasis (r=0.662; P<0.0001). Based on the findings of the Ga-68 DOTANOC PET/CT scan, 3 out of 40 patients underwent definitive treatment for their primary tumour (1 gastric, 1 ileal and 1 prostatic tumour). One patient was being planned for resection of primary rectal lesion at the time of data-collection. Thirty-six out of 68 patients were started on long-acting somatostatin analogues or chemotherapy or targeted therapy. Two patients underwent multiple cycles of peptide receptor radionuclide therapy (PRRNT) using 90Y and 177Lu labeled somatostatin analogues. Conclusions Our findings indicate that Ga-68 DOTANOC PET/CT is a promising imaging modality in patients with metastatic NETs of unknown origin for detection of the primary site and in guiding their therapeutic management. PMID:27284479

4. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. August, 1955. XBB 689-5508. BEVATRON MODEL (L. TO R.) WITH L. SMITH, McMILLAN, E.O. LAWRENCE, LOFGREN, BROBECK, AND SEWELL - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

29. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. July, 1959. Morgue 1959-46 (P-1). ALVAREZ BUBBLE CHAMBER GROUP (L. TO R.) HERNANDEZ, McMILLAN, ALVAREZ, GOW - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

Iatrogenic Buschke's disease (Michelin man syndrome)

PubMed

Ahmad, N; Lawrence, J R; Macdonald, J W

1988-02-01

Scleredema [corrected] adultorum as originally described by Buschke in 1900, is cutaneous thickening of unknown aetiology. Since then several cases have been reported which have illustrated different aspects of the disease but the exact aetiology, pathogenesis and prognosis remain uncertain. Disease of possible iatrogenic origin appears not to have been described previously.

47. Photocopy of photograph (negative made from original photograph property ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Photocopy of photograph (negative made from original photograph property of The Wichita Eagle newspaper, Wichita, Kansas), photographer unknown, date on photograph 1948. View of southeast, Building 8 - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

13. Photocopy of photograph (original print in the private collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph (original print in the private collection of Mr. Orton Camp, Waterbury, Connecticut) ca. 1890, photographer unknown DEXTER'S DRUG STORE IN SOUTHWEST CORNER OF HOTCHKISS BLOCK ON EAST MAIN STREET - Hotchkiss Block (Irving Block), 11 East Main Street, Waterbury, New Haven County, CT

Cocos nucifera L

Treesearch

James A. Allen

2002-01-01

The genus Cocos is monotypic. Cocos nucifera is believed to have originated in the Old World tropics, but the natural range is unknown and the origin of the species is the subject of considerable debate (Harries 1978, Parrotta 1993). Dispersal by humans has played a major role in the naturalization of the species on tropical...

[A fever of finally known origin].

PubMed

Jenni, Stefan; Kositz, Christian; Diethelm, Markus; Albrich, Werner

2014-05-21

We present the case of a 77 year old man with fever of unknown origin. Despite a thorough assessment in hospital the diagnosis could only be made after discharge when positive results for C. burnetii serology revealed acute Q-fever. However, retrospectively history and clinical findings matched well with acute Q-fever.

26. Photo copy of photograph, (original in Forest Service Office, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. Photo copy of photograph, (original in Forest Service Office, Elkins, WV), photographer unknown, ca. 1936. VIEW NORTHWEST, GARAGE (DEMOLISHED), NURSERY MANAGER'S GARAGE AND RESIDENCE, AND PACKING BUILDING, TRANSPLANT SHEDS AND PLOW IN FOREGROUND. - Parsons Nursery, South side of U.S. Route 219, Parsons, Tucker County, WV

20. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative BUILDING OF DAM No. 3, LOOKING SOUTH - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

19. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative BUILDING OF DAM No. 3, FROM THE NORTH - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

22. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative BUILDING OF DAM NO. 3, LOOKING SOUTH - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

4. Photocopy of an engraving (original in the collection of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of an engraving (original in the collection of the Claremont Historical Society) artist unknown, no date FIRST COAL CUTTER MANUFACTURED BY THE SULLIVAN MACHINERY COMPANY. THIS DEVICE WAS POWERED BY HAND. - Sullivan Machinery Company, Main Street between Pearl & Water Streets, Claremont, Sullivan County, NH

17. Photocopy of drawing (original 8 x 101/2 inch plate ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of drawing (original 8 x 10-1/2 inch plate located in: USDA Forest Service, North Pacific Region, recreation handbook, date unknown). COMMUNITY BLDG., PLATE A-9 (enlarged from a 4x5 negative) - Austin Pass Warming Hut, Washington Highway 542, Glacier, Whatcom County, WA

4. Photocopy of photograph, original negative in the possession of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of photograph, original negative in the possession of John R. Morison, Peterborough, New Hampshire. Photographer unknown, 14 September 1888. INSIDE CAISSON PIER IV, 60 FEET BELOW WATER LINE, 25 POUNDS AIR PRESSURE - Sioux City Bridge, Spanning the Missouri River, Sioux City, Woodbury County, IA

Photocopy of photograph (original in collection of U.S. Coast Guard ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original in collection of U.S. Coast Guard Civil Engineering Unit Providence, Warwick, RI) photographer unknown, 1975 Aerial view directly above - U.S. Coast Guard Sandy Hook Station, Western Docking Structure, West of intersection of Canfield Road & Hartshorne Drive, Highlands, Monmouth County, NJ

Photocopy of photograph (original in collection of U.S. Coast Guard ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original in collection of U.S. Coast Guard Civil Engineering Unit Providence, Warwick, RI) photographer unknown, 1977 Aerial view looking northeast - U.S. Coast Guard Sandy Hook Station, Western Docking Structure, West of intersection of Canfield Road & Hartshorne Drive, Highlands, Monmouth County, NJ

11. Photocopy of photograph in the collection of Photographic Branch, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph in the collection of Photographic Branch, Puget Sound Naval Shipyard, Bremerton, WA. Original is labelled: Yard Photo 42. Date unknown, probably 1940's. Photographer unknown. HABS negative is a 4x5' copy negative. Perspective view of NE corner of Building 78. - Puget Sound Naval Shipyard, Administration Building, Farragut Avenue, Bremerton, Kitsap County, WA

[Characterization of stem cells derived from the neonatal auditory sensory epithelium].

PubMed

Diensthuber, M; Heller, S

2010-11-01

In contrast to regenerating hair cell-bearing organs of nonmammalian vertebrates the adult mammalian organ of Corti appears to have lost its ability to maintain stem cells. The result is a lack of regenerative ability and irreversible hearing loss following auditory hair cell death. Unexpectedly, the neonatal auditory sensory epithelium has recently been shown to harbor cells with stem cell features. The origin of these cells within the cochlea's sensory epithelium is unknown. We applied a modified neurosphere assay to identify stem cells within distinct subregions of the neonatal mouse auditory sensory epithelium. Sphere cells were characterized by multiple markers and morphologic techniques. Our data reveal that both the greater and the lesser epithelial ridge contribute to the sphere-forming stem cell population derived from the auditory sensory epithelium. These self-renewing sphere cells express a variety of markers for neural and otic progenitor cells and mature inner ear cell types. Stem cells can be isolated from specific regions of the auditory sensory epithelium. The distinct features of these cells imply a potential application in the development of a cell replacement therapy to regenerate the damaged sensory epithelium.

[Usefulness of FDG-PET/CT for the diagnosis of intravascular large B-cell lymphoma presenting with fever of unknown origin and renal dysfunction].

PubMed

Yago, Kazuhiro; Yanagita, Soshi; Aono, Maki; Matsuo, Ken; Shimada, Hideto

2009-06-01

A 76-year-old man presented with fever of unknown origin and renal dysfunction. Laboratory examination revealed anemia, thrombocytopenia, hypoalbuminemia, proteinuria, and elevations of C-reactive protein, lactic dehydrogenase, creatinine and ferritin. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging showed FDG accumulation in the renal cortex and spleen. Based on the imaging study, renal biopsy was performed and histological diagnosis of intravascular large B-cell lymphoma (IVLBCL) was made. Renal impairment due to IVLBCL is uncommon and is often difficult to diagnose early. FDG-PET/CT may be a useful tool for the early diagnosis of IVLBCL.

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay.

PubMed

Lordkipanidzé, Marie; Lowe, Gillian C; Kirkby, Nicholas S; Chan, Melissa V; Lundberg, Martina H; Morgan, Neil V; Bem, Danai; Nisar, Shaista P; Leo, Vincenzo C; Jones, Matthew L; Mundell, Stuart J; Daly, Martina E; Mumford, Andrew D; Warner, Timothy D; Watson, Steve P

2014-02-20

Up to 1% of the population have mild bleeding disorders, but these remain poorly characterized, particularly with regard to the roles of platelets. We have compared the usefulness of Optimul, a 96-well plate-based assay of 7 distinct pathways of platelet activation to characterize inherited platelet defects in comparison with light transmission aggregometry (LTA). Using Optimul and LTA, concentration-response curves were generated for arachidonic acid, ADP, collagen, epinephrine, Thrombin receptor activating-peptide, U46619, and ristocetin in samples from (1) healthy volunteers (n = 50), (2) healthy volunteers treated with antiplatelet agents in vitro (n = 10), and (3) patients with bleeding of unknown origin (n = 65). The assays gave concordant results in 82% of cases (κ = 0.62, P < .0001). Normal platelet function results were particularly predictive (sensitivity, 94%; negative predictive value, 91%), whereas a positive result was not always substantiated by LTA (specificity, 67%; positive predictive value, 77%). The Optimul assay was significantly more sensitive at characterizing defects in the thromboxane pathway, which presented with normal responses with LTA. The Optimul assay is sensitive to mild platelet defects, could be used as a rapid screening assay in patients presenting with bleeding symptoms, and detects changes in platelet function more readily than LTA. This trial was registered at www.isrctn.org as #ISRCTN 77951167.

Identification of RNA molecules by specific enzyme digestion and mass spectrometry: software for and implementation of RNA mass mapping

PubMed Central

Matthiesen, Rune; Kirpekar, Finn

2009-01-01

The idea of identifying or characterizing an RNA molecule based on a mass spectrum of specifically generated RNA fragments has been used in various forms for well over a decade. We have developed software—named RRM for ‘RNA mass mapping’—which can search whole prokaryotic genomes or RNA FASTA sequence databases to identify the origin of a given RNA based on a mass spectrum of RNA fragments. As input, the program uses the masses of specific RNase cleavage of the RNA under investigation. RNase T1 digestion is used here as a demonstration of the usability of the method for RNA identification. The concept for identification is that the masses of the digestion products constitute a specific fingerprint, which characterize the given RNA. The search algorithm is based on the same principles as those used in peptide mass fingerprinting, but has here been extended to work for both RNA sequence databases and for genome searches. A simple and powerful probability model for ranking RNA matches is proposed. We demonstrate viability of the entire setup by identifying the DNA template of a series of RNAs of biological and of in vitro transcriptional origin in complete microbial genomes and by identifying authentic 16S ribosomal RNAs in a ‘small ribosomal subunit RNA’ database. Thus, we present a new tool for a rapid identification of unknown RNAs using only a few picomoles of starting material. PMID:19264806

Hemophagocytic syndrome secondary to tuberculosis at 24-week gestation.

PubMed

Fernández, Alexandra Arteaga; de Velasco Pérez, David Fernández; Fournier, M C Jiménez; Moreno Del Prado, J C; Torras, B Paraíso; Cañete Palomo, M L

2017-01-01

Hemophagocytic syndrome is a life-threatening disease characterized by the uncontrolled activation of macrophages, resulting in hemophagocytosis of blood cells in the bone marrow. A 20-year-old gravida at 23-week and 5-day gestation was admitted to hospital to evaluate fever up to 104°F of unknown origin, moderate cytopenia, and elevated levels of liver enzymes. Bone marrow biopsy confirmed hemophagocytic syndrome, and polymerase chain reaction came back positive for Mycobacterium tuberculosis. Supportive care and tuberculosis treatment resulted in clinical improvement. At 27 weeks and 5 days, premature rupture of the membranes occurred, and because of the high probability of reactivating the hemophagocytic syndrome, a cesarean section was performed at 29-week and 2-day gestation. Hemophagocytic syndrome is an uncommon disease which rarely appears during pregnancy. Early diagnosis and treatment can save both maternal and fetal lives.

[Sudden cardiac death due to sarcoidosis. Case report].

PubMed

Sejben, István; Som, Zoltán; Cserni, Gábor

2017-07-01

Sarcoidosis is a systemic granulomatous disease of unknown aetiology, which is characterized by bilateral hilar lymphadenopathy and pulmonary disease. Clinically detected cardiac involvement occurs in 5% of sarcoid patients, although cardiac manifestations are discovered in 25% of the cases at autopsy. Sarcoid heart disease frequently causes atrioventricular block. The authors present the case of a 44-year-old man with bradycardia. On admission, second degree Mobitz II, then third degree atrioventricular block was diagnosed. Coronarography showed normal coronary arteries. 2.5 years following artificial Biotronik Entovis DR type pacemaker implantation, sudden cardiac death occurred. Autopsy revealed sarcoidosis with cardiac, pulmonary, splenic, renal and lymph node involvement. In case of young or middle-aged patients with atrioventricular block, it is best to search for other causes if the most common coronary origin can be excluded. Orv Hetil. 2017; 158(27): 1067-1070.

Absence of histopathological changes of ileum and colon in functional chronic diarrhea associated with bile acid malabsorption, assessed by SeHCAT test: a prospective study.

PubMed

Sciarretta, G; Furno, A; Morrone, B; Malaguti, P

1994-07-01

Chronic diarrhea of unknown origin is often associated with bile acid malabsorption, the pathogenetic role of which is uncertain. The aim of this study was to identify morphological abnormalities in the ileal and colonic mucosa in patients with this disorder. We performed a prospective and blinded histopathological study (between June 1991 and November 1992) of endoscopic biopsies of the distal ileum and colon of 23 patients suffering from chronic diarrhea of unknown origin. In 14, the SeHCAT (75-selena-homo-cholic acid taurine) test was abnormal owing to bile acid malabsorption; in the other nine, the diarrhea control group, the test results were normal. A detailed evaluation of surface epithelium, immune response and inflammatory changes was made. in two patients and two controls, mild villous atrophy was observed; there was also slight inflammation of the ileal and colonic mucosa occurring with the same frequency in both groups. A slight replacement of goblet cells was more evident in the diarrhea control group. Chronic diarrhea of unknown origin associated with bile acid malabsorption does not involve specific morphological changes of ileal or colonic mucosa, and its pathogenesis must be looked for in dysfunction of the ileum and/or colon.

Archaeology through Computational Linguistics: Inscription Statistics Predict Excavation Sites of Indus Valley Artifacts

ERIC Educational Resources Information Center

Recchia, Gabriel L.; Louwerse, Max M.

2016-01-01

Computational techniques comparing co-occurrences of city names in texts allow the relative longitudes and latitudes of cities to be estimated algorithmically. However, these techniques have not been applied to estimate the provenance of artifacts with unknown origins. Here, we estimate the geographic origin of artifacts from the Indus Valley…

36. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

36. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. September 21, 1956. BEV-1154. DISCOVERERS OF ANTI-NEUTRON--(L. to R.) W. WENZEL, B. CORK, G. LAMBERTSON, AND O. PICCIONI, WITH FOCUS MAGNET. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

34. Photocopy of photograph (original print located in LBNL Photo ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Photocopy of photograph (original print located in LBNL Photo Lab Collection). Photographer unknown. October 6, 1955. BEV-938. ANTI-PROTON SET-UP WITH WORK GROUP; E. SEGRE, C. WIEGAND, E. LOFGREN, O. CHAMBERLAIN, T. YPSILANTIS. B-51. - University of California Radiation Laboratory, Bevatron, 1 Cyclotron Road, Berkeley, Alameda County, CA

13. Photocopy of photograph (original photograph in possession of 30th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Photocopy of photograph (original photograph in possession of 30th Audiovisual Squadron, Vandenberg Air Force Base, California). Photography by United States Air Force, date unknown. THRUST AUGMENTED THOR PREPARED FOR LAUNCH FROM SLC-3W. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

3. Photographic copy of historic photograph. JulyDec. 1947 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photographic copy of historic photograph. July-Dec. 1947 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

4. Photographic copy of historic photograph. Jan.June 1948 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photographic copy of historic photograph. Jan.-June 1948 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

10. Photographic copy of historic photograph. Jan.June 1954 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photographic copy of historic photograph. Jan.-June 1954 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

7. Photographic copy of historic photograph. Jan.June 1951 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photographic copy of historic photograph. Jan.-June 1951 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

8. Photographic copy of historic photograph. JulyDec. 1951 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photographic copy of historic photograph. July-Dec. 1951 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

6. Photographic copy of historic photograph. Jan.June 1951 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photographic copy of historic photograph. Jan.-June 1951 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

5. Photographic copy of historic photograph. JulyDec. 1950 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Photographic copy of historic photograph. July-Dec. 1950 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

2. Photographic copy of historic photograph. JulyDec. 1947 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photographic copy of historic photograph. July-Dec. 1947 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

1. Photographic copy of historic photograph. JulySept. 1946 OAMA. (Original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photographic copy of historic photograph. July-Sept. 1946 OAMA. (Original print located at Ogden Air Logistics Center, Hill Air Force Base, Utah). Photographer unknown. - Hill Field, North of State Highway 193, East of Interstate 15, South of Davis-Weber Canal, West of Wherry Road, Layton, Davis County, UT

3. Photocopy of photograph (Original print, Phillip McCracken, courtesy of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photocopy of photograph (Original print, Phillip McCracken, courtesy of Bill Mitchell.) Photographer unknown, 1924. Cold Storage Warehouse on the left, north and west facades. On the right, north facade of the Hay and Grain Warehouse. - Curtis Wharf, Cold Storage Warehouse, O & Second Streets, Anacortes, Skagit County, WA

46. Photocopy of photograph (negative made from original photograph property ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Photocopy of photograph (negative made from original photograph property of The Wichita Eagle newspaper, Wichita, Kansas), photographer unknown, date on photograph 1943. View southeast, Building 8 is first structure on right - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

10. Photographic copy of photograph (original print in possession of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Photographic copy of photograph (original print in possession of CSSD-HO, Huntsville, AL). Photographer unknown. Comparison of Spartan and sprint missiles. The sprint missile is on the left; the Spartan missile is on the right - Stanley R. Mickelsen Safeguard Complex, Missile Launch Area, Within Exclusion Area, Nekoma, Cavalier County, ND

14. Photocopy of photograph original print located at University Archives, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph original print located at University Archives, Hayden Library, Arizona State University, Tempe, Arizona. Photographer unknown, 1902 VIEW SHOWING TRAIN WRECK ON MARICOPA AND PHOENIX RAILROAD CAUSED BY BRIDGE FAILURE RESULTING FROM FLOOD DAMAGE - Ash Avenue Bridge, Spanning Salt River at Foot of Ash Avenue, Tempe, Maricopa County, AZ

34. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Photographic copy of photograph (ca. 1962, original print in possession of Army Corps of Engineers, Ft. Belvoir, Virginia) Photographer unknown. View of launch control facility under construction, security gate at left - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

2. Photocopy of photograph (original photograph in possession of Atlanta ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of photograph (original photograph in possession of Atlanta Housing Authority, Atlanta, GA). Photographer unknown, circa 1940. Aerial view of Clark Howell Homes, center, Techwood Homes, left, Georgia Institute of Technology, bottom. - Clark Howell Homes (Public Housing), Bounded by North Avenue, Lovejoy Street, Mills Street & Luckie Street, Atlanta, Fulton County, GA

1. Photocopy of photograph (original photograph in possession of Atlanta ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of photograph (original photograph in possession of Atlanta Housing Authority, Atlanta, GA). Photographer unknown, circa 1940. Aerial view, Clark Howell Homes, left, Techwood Homes, right, Georgia Institute of Technology, top, right. - Clark Howell Homes (Public Housing), Bounded by North Avenue, Lovejoy Street, Mills Street & Luckie Street, Atlanta, Fulton County, GA

The origin of Ceratocystis fagacearum, the oak wilt fungus

Treesearch

Jennifer Juzwik; Thomas C. Harrington; William L. MacDonald; David N. Appel

2008-01-01

The oak wilt pathogen, Ceratocystis fagacearum, may be another example of a damaging, exotic species in forest ecosystems in the United States. Though C. fagacearum has received much research attention, the origin of the fungus is unknown. The pathogen may have been endemic at a low incidence until increased disturbances, changes...

24. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative VIEW OF THE OLD TIMBER CRIB DAM, LOOKING EAST FROM THE NORTH BANK - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

11. Photographic copy of photograph (original print in possession of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photographic copy of photograph (original print in possession of CSSD-HO, Huntsville, AL). Photographer unknown. View of rocket models, allowing a comparison of the Spartan, galosh (USSR), minute man III, and SS-9 (USSR) missiles - Stanley R. Mickelsen Safeguard Complex, Missile Launch Area, Within Exclusion Area, Nekoma, Cavalier County, ND

23. Photocopy of original photo from Corps of Engineers, Los ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown; report located at City of San Luis Obispo.) CONSTRUCTION PHOTO SHOWING CURVED CONCRETE CHUTE SPILLWAY. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

21. Photocopy of original photo from Corps of Engineers, Los ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown; report located at City of San Luis Obispo.) SALINAS DAM UNDER CONSTRUCTION IN 1941. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

24. Photocopy of original photo from Corps of Engineers, Los ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown, report located at City of San Luis Obispo.) SALINAS DAM COMPLETION PHOTO. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

76. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. DISASSEMBLING CRANE TOWER FROM SOUTH ISLAND SPILLWAY. REMOVING CABLE TOWER. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

Photocopy of photograph (original in collection of U.S. Coast Guard ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of photograph (original in collection of U.S. Coast Guard Civil Engineering Unit Providence, Warwich, RI), photographer unknown, 1977 view south, showing western docking structure and ordnance wharf - U.S. Coast Guard Sandy Hook Station, Western Docking Structure, West of intersection of Canfield Road & Hartshorne Drive, Highlands, Monmouth County, NJ

Mass Cytometry Identifies Distinct Lung CD4+ T Cell Patterns in Löfgren’s Syndrome and Non-Löfgren’s Syndrome Sarcoidosis

PubMed Central

Kaiser, Ylva; Lakshmikanth, Tadepally; Chen, Yang; Mikes, Jaromir; Eklund, Anders; Brodin, Petter; Achour, Adnane; Grunewald, Johan

2017-01-01

Sarcoidosis is a granulomatous disorder of unknown etiology, characterized by accumulation of activated CD4+ T cells in the lungs. Disease phenotypes Löfgren’s syndrome (LS) and “non-LS” differ in terms of clinical manifestations, genetic background, HLA association, and prognosis, but the underlying inflammatory mechanisms largely remain unknown. Bronchoalveolar lavage fluid cells from four HLA-DRB1*03+ LS and four HLA-DRB1*03− non-LS patients were analyzed by mass cytometry, using a panel of 33 unique markers. Differentially regulated CD4+ T cell populations were identified using the Citrus algorithm, and t-stochastic neighborhood embedding was applied for dimensionality reduction and single-cell data visualization. We identified 19 individual CD4+ T cell clusters differing significantly in abundance between LS and non-LS patients. Seven clusters more frequent in LS patients were characterized by significantly higher expression of regulatory receptors CTLA-4, PD-1, and ICOS, along with low expression of adhesion marker CD44. In contrast, 12 clusters primarily found in non-LS displayed elevated expression of activation and effector markers HLA-DR, CD127, CD39, as well as CD44. Hierarchical clustering further indicated functional heterogeneity and diverse origins of T cell receptor Vα2.3/Vβ22-restricted cells in LS. Finally, a near-complete overlap of CD8 and Ki-67 expression suggested larger influence of CD8+ T cell activity on sarcoid inflammation than previously appreciated. In this study, we provide detailed characterization of pulmonary T cells and immunological parameters that define separate disease pathways in LS and non-LS. With direct association to clinical parameters, such as granuloma persistence, resolution, or chronic inflammation, these results provide a valuable foundation for further exploration and potential clinical application. PMID:28955342

Systematic analytical characterization of new psychoactive substances: A case study.

PubMed

Lobo Vicente, Joana; Chassaigne, Hubert; Holland, Margaret V; Reniero, Fabiano; Kolář, Kamil; Tirendi, Salvatore; Vandecasteele, Ine; Vinckier, Inge; Guillou, Claude

2016-08-01

New psychoactive substances (NPS) are synthesized compounds that are not usually covered by European and/or international laws. With a slight alteration in the chemical structure of existing illegal substances registered in the European Union (EU), these NPS circumvent existing controls and are thus referred to as "legal highs". They are becoming increasingly available and can easily be purchased through both the internet and other means (smart shops). Thus, it is essential that the identification of NPS keeps up with this rapidly evolving market. In this case study, the Belgian Customs authorities apprehended a parcel, originating from China, containing two samples, declared as being "white pigments". For routine identification, the Belgian Customs Laboratory first analysed both samples by gas-chromatography mass-spectrometry and Fourier-Transform Infrared spectroscopy. The information obtained by these techniques is essential and can give an indication of the chemical structure of an unknown substance but not the complete identification of its structure. To bridge this gap, scientific and technical support is ensured by the Joint Research Centre (JRC) to the European Commission Directorate General for Taxation and Customs Unions (DG TAXUD) and the Customs Laboratory European Network (CLEN) through an Administrative Arrangement for fast recognition of NPS and identification of unknown chemicals. The samples were sent to the JRC for a complete characterization using advanced techniques and chemoinformatic tools. The aim of this study was also to encourage the development of a science-based policy driven approach on NPS. These samples were fully characterized and identified as 5F-AMB and PX-3 using (1)H and (13)C nuclear magnetic resonance (NMR), high-resolution tandem mass-spectrometry (HR-MS/MS) and Raman spectroscopy. A chemoinformatic platform was used to manage, unify analytical data from multiple techniques and instruments, and combine it with chemical and structural information. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Globally Convergent Numerical Methods for Coefficient Inverse Problems

DTIC Science & Technology

2008-09-23

backgrounds. Probing radiations are usually thought as electric and acoustic waves for the first two applications and light originated by lasers in...fundamental laws of physics. Electric , acoustic or light scattering properties of both unknown targets and the backgrounds are described by coefficients of...with the back-reflected data here, Army applications are quite feasible. The 2-D inverse problem of the determination of the unknown electric

15. Photographic copy of photograph dated ca. 1929; Photographer unknown; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photographic copy of photograph dated ca. 1929; Photographer unknown; Original in Rath collection at Grout Museum, Waterloo, Iowa; Filed under: Rath Packing Company, Box 4; THE RATH COMPLEX IN THE LATE 1920S; LOOKING WEST FROM 18TH STREET; LARGE BUILDING AT CENTER IS HOG KILL (BUILDING 40) - Rath Packing Company, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

"A Marriage on the Rocks": An Unknown Letter by William H. Kilpatrick about His Project Method

ERIC Educational Resources Information Center

Knoll, Michael

2010-01-01

William H. Kilpatrick is worldwide known as "Mr. Project Method." But the origin of his celebrated paper of 1918 has never been explored. The discovery of a hitherto unknown letter reveals that Kilpatrick was an educational entrepreneur who, without regard for language and tradition, adopted the term "project" and used it in a provocative new way…

Physcomitrella patens MAX2 characterization suggests an ancient role for this F-box protein in photomorphogenesis rather than strigolactone signalling.

PubMed

Lopez-Obando, Mauricio; de Villiers, Ruan; Hoffmann, Beate; Ma, Linnan; de Saint Germain, Alexandre; Kossmann, Jens; Coudert, Yoan; Harrison, C Jill; Rameau, Catherine; Hills, Paul; Bonhomme, Sandrine

2018-05-21

Strigolactones (SLs) are key hormonal regulators of flowering plant development and are widely distributed amongst streptophytes. In Arabidopsis, SLs signal via the F-box protein MORE AXILLARY GROWTH2 (MAX2), affecting multiple aspects of development including shoot branching, root architecture and drought tolerance. Previous characterization of a Physcomitrella patens moss mutant with defective SL synthesis supports an ancient role for SLs in land plants, but the origin and evolution of signalling pathway components are unknown. Here we investigate the function of a moss homologue of MAX2, PpMAX2, and characterize its role in SL signalling pathway evolution by genetic analysis. We report that the moss Ppmax2 mutant shows very distinct phenotypes from the moss SL-deficient mutant. In addition, the Ppmax2 mutant remains sensitive to SLs, showing a clear transcriptional SL response in dark conditions, and the response to red light is also altered. These data suggest divergent evolutionary trajectories for SL signalling pathway evolution in mosses and vascular plants. In P. patens, the primary roles for MAX2 are in photomorphogenesis and moss early development rather than in SL response, which may require other, as yet unidentified, factors. © 2018 INRA New Phytologist © 2018 New Phytologist Trust.

Genetic characterization and phylogeny of pigeon paramyxovirus isolate (PPMV-1) from Pakistan.

PubMed

Akhtar, Sameera; Muneer, Muhammad Akram; Muhammad, Khushi; Tipu, Muhammad Yasin; Rabbani, Masood; Ul-Rahman, Aziz; Shabbir, Muhammad Zubair

2016-01-01

Knowing the genome characteristics of circulating Newcastle disease viruses [avian paramyxoviruses (APMV-1) and pigeon paramyxoviruses (PPMV-1)] is important to devise appropriate diagnostics and control strategies. APMVs originating from chicken and wildlife in Pakistan are well-elucidated; nevertheless, molecular characterization for the circulating PPMV-1 is largely unknown. Here, we have performed fusion (F) and hemagglutinin (HN) gene based characterization of PPMV-1 isolated from an outbreak in a pigeon flock. With F0 proteolytic cleavage site (112RRQKR↓F117), characteristic of velogenic/mesogenic serotype, the complete F and HN gene based sequence analysis of the isolate revealed evolutionary relationship to genotype VI. Further analysis of hyper-variable region of F-gene demonstrated clustering of the study isolate with genotype VIb. The deduced residue analysis for both F and HN protein showed a number of substitution mutations in the functional domains distinct from representative strains of each genotype including the vaccine strains; some of them were found exclusive to the study isolate. Though limited and preliminary data, the findings enhance our knowledge towards circulating strains of PPMVs in Pakistan. Further studies are needed to ascertain its potential for transmission in the wild birds, commercial and backyard poultry and its subsequent shedding into the environment.

Characterization of the reference wave in a compact digital holographic camera.

PubMed

Park, I S; Middleton, R J C; Coggrave, C R; Ruiz, P D; Coupland, J M

2018-01-01

A hologram is a recording of the interference between an unknown object wave and a coherent reference wave. Providing the object and reference waves are sufficiently separated in some region of space and the reference beam is known, a high-fidelity reconstruction of the object wave is possible. In traditional optical holography, high-quality reconstruction is achieved by careful reillumination of the holographic plate with the exact same reference wave that was used at the recording stage. To reconstruct high-quality digital holograms the exact parameters of the reference wave must be known mathematically. This paper discusses a technique that obtains the mathematical parameters that characterize a strongly divergent reference wave that originates from a fiber source in a new compact digital holographic camera. This is a lensless design that is similar in principle to a Fourier hologram, but because of the large numerical aperture, the usual paraxial approximations cannot be applied and the Fourier relationship is inexact. To characterize the reference wave, recordings of quasi-planar object waves are made at various angles of incidence using a Dammann grating. An optimization process is then used to find the reference wave that reconstructs a stigmatic image of the object wave regardless of the angle of incidence.

Characterization of myocardial lesions associated with cardiomyopathy syndrome in Atlantic salmon, Salmo salar L., using laser capture microdissection.

PubMed

Wiik-Nielsen, J; Løvoll, M; Fritsvold, C; Kristoffersen, A B; Haugland, Ø; Hordvik, I; Aamelfot, M; Jirillo, E; Koppang, E O; Grove, S

2012-12-01

Cardiomyopathy syndrome (CMS) in Atlantic salmon, Salmo salar L., is characterized by focal infiltration in the spongy myocardium and endocardium of the heart. The origin of the mononuclear infiltrate is unknown. Using experimentally infected fish, we investigated localization of the causative agent, piscine myocarditis virus (PMCV), within the heart and characterized the cell population associated with myocardial lesions. Cellular and transcriptional characteristics in the lesions were compared with adjacent non-infiltrated tissues using laser capture microdissection, RT-qPCR and immunohistochemistry. Our results reveal that PMCV is almost exclusively present in myocardial lesions. The inflammatory infiltrate comprises a variety of leucocyte populations, including T cells, B cells, MHC class II(+) and CD83(+) cells, most likely of the macrophage line. Correlation analyses demonstrated co-ordinated leucocyte activity at the site of the virus infection. Cellular proliferation and/or DNA repair was demonstrated within the myocardial lesions. Different cell populations, mainly myocytes, stained positive for proliferating cell nuclear antigen (PCNA). Densities of endothelial cells and fibroblasts were not significantly increased. The simultaneous presence of PMCV and various inflammatory cells in all myocardial lesions analysed may indicate that both viral lytic and immunopathological effects may contribute to the pathogenesis of CMS. © 2012 Blackwell Publishing Ltd.

Activity of insulin growth factors and shrimp neurosecretory organ extracts on a lepidopteran cell line.

PubMed

Hatt, P J; Liebon, C; Morinière, M; Oberlander, H; Porcheron, P

1997-01-01

Ecdysteroids, or molting hormones, have been proven to be key differentiation regulators for epidermal cells in the postembryonic development of arthropods. Regulators of cell proliferation, however, remain largely unknown. To date, no diffusible insect peptidic growth factors have been characterized. Molecules structurally related to insulin have been discovered in insects, as in other eucaryotes. We developed in vitro tests for the preliminary characterization of potential growth factors in arthropods by adapting the procedures designed to detect such factors in vertebrates to an insect cell line (IAL-PID2) established from imaginal discs of the Indian meal moth. We verified the ability of these tests to measure the proliferation of IAL-PID2 cells. We tested mammalian insulin and insulin-like growth factors (IGF-I, IGF-II). Following an arrest of cell proliferation by serum deprivation, IGF-I and IGF-II caused partial resumption of the cell cycle, evidenced by DNA synthesis. In contrast, the addition of 20-hydroxyecdysone arrested the proliferation of the IAL-PID2 cells. The cell line was then used in a test for functional characterization of potential growth factors originating from the penaeid shrimp, Penaeus vannamei. Crude extracts of neurosecretory and nervous tissues, eyestalks, and ventral neural chain compensated for serum deprivation and stimulated completion of mitosis. Arch.

Geophysical Characterization of a Rare Earth Element Enriched Carbonatite Terrane at Mountain Pass, California Eastern Mojave Desert

NASA Astrophysics Data System (ADS)

Denton, Kevin M.

Mountain Pass, California, located in the eastern Mojave Desert, hosts one of the world's richest rare earth element (REE) deposits. The REE-rich rocks occur in a 2.5 km- wide, north-northwest trending zone of Mesoproterozoic (1.4-1.42 Ga) stocks and dikes, which intrude a larger Paleoproterozoic (1.7 Ga) schist-gneiss terrane that extends 10 km southward from Clark Mountain to the Mescal Range. Several REE-enriched bodies make up the Mountain Pass intrusive suite including shonkinite, syenite, and granite comprising an ultrapotassic intrusive suite and the Sulphide Queen carbonatite body. Two-dimensional modeling of gravity, magnetic, and electrical resistivity data reveals that the Mountain Pass intrusive suite is associated with a local gravity high that is superimposed on a 4-km wide gravity terrace. Rock property data indicate that the Mountain Pass intrusive suite is unusually nonmagnetic at the surface (2.0 x 10-3 SI, n = 67). However, aeromagnetic data indicate that these rocks occur along the eastern edge of a prominent north-northwest trending aeromagnetic high of unknown origin. The source of this unknown magnetic anomaly is 2-3 km below the surface and coincides with a body of rock having high electrical conductivity. Electrical resistivity models indicate that this unknown magnetic anomaly is several orders of magnitude more conductive (103 O•m) than the surrounding rock. Combined geophysical data suggest that the carbonatite and its associated ultrapotassic intrusive suite were preferentially emplaced along a northwest zone of weakness and/or a fault.

Histone acetylation regulates the time of replication origin firing.

PubMed

Vogelauer, Maria; Rubbi, Liudmilla; Lucas, Isabelle; Brewer, Bonita J; Grunstein, Michael

2002-11-01

The temporal firing of replication origins throughout S phase in yeast depends on unknown determinants within the adjacent chromosomal environment. We demonstrate here that the state of histone acetylation of surrounding chromatin is an important regulator of temporal firing. Deletion of RPD3 histone deacetylase causes earlier origin firing and concurrent binding of the replication factor Cdc45p to origins. In addition, increased acetylation of histones in the vicinity of the late origin ARS1412 by recruitment of the histone acetyltransferase Gcn5p causes ARS1412 alone to fire earlier. These data indicate that histone acetylation is a direct determinant of the timing of origin firing.

Machine intelligence-based decision-making (MIND) for automatic anomaly detection

NASA Astrophysics Data System (ADS)

Prasad, Nadipuram R.; King, Jason C.; Lu, Thomas

2007-04-01

Any event deemed as being out-of-the-ordinary may be called an anomaly. Anomalies by virtue of their definition are events that occur spontaneously with no prior indication of their existence or appearance. Effects of anomalies are typically unknown until they actually occur, and their effects aggregate in time to show noticeable change from the original behavior. An evolved behavior would in general be very difficult to correct unless the anomalous event that caused such behavior can be detected early, and any consequence attributed to the specific anomaly. Substantial time and effort is required to back-track the cause for abnormal behavior and to recreate the event sequence leading to abnormal behavior. There is a critical need therefore to automatically detect anomalous behavior as and when they may occur, and to do so with the operator in the loop. Human-machine interaction results in better machine learning and a better decision-support mechanism. This is the fundamental concept of intelligent control where machine learning is enhanced by interaction with human operators, and vice versa. The paper discusses a revolutionary framework for the characterization, detection, identification, learning, and modeling of anomalous behavior in observed phenomena arising from a large class of unknown and uncertain dynamical systems.

Fever of unknown origin (FUO): CMV infectious mononucleosis or lymphoma?

PubMed

Cunha, Burke A; Chawla, Karishma

2018-07-01

Fever of unknown origin (FUO) refers to fevers of > 101 °F that persist for > 3 weeks and remain undiagnosed after a focused inpatient or outpatient workup. FUO may be due to infectious, malignant/neoplastic, rheumatic/inflammatory, or miscellaneous disorders. The FUO category determines the focus of the diagnostic workup. In the case presented of an FUO in a young woman, there were clinical findings of both CMV infectious mononucleosis or a lymphoma, e.g., highly elevated ESR, elevated ferritin levels, and elevated ACE level, β-2 microglobulins. The indium scan showed intense splenic uptake. Lymph node biopsy, PET scan, and flow cytometry were negative for lymphoma. CMV infectious mononucleosis was the diagnosis, and she made a slow recovery.

Malignant Melanoma Presenting as a Mediastinal Malignant Melanoma Presenting as a Mediastinal Unknown Primary Origin?

PubMed

Pujani, Mukta; Hassan, Mohd Jaseem; Jetley, Sujata; Raina, Prabhat Kumar; Kumar, Mukesh

2017-01-01

The most common site of primary malignant melanoma is the skin, however, virtually any organ system may be involved. Metastatic melanoma of unknown primary origin accounts for approximately 2-6% of all melanoma cases. The mediastinum as the site for malignant melanoma is extremely rare, both as a primary or metastatic lesion. Primary malignant melanoma of mediastinum is very rare with only a handful of reports in the literature. We hereby report a rare case of malignant melanoma of mediastinum in a 31 year old male who was initially misdiagnosed on fine needle aspiration cytology as adenocarcinoma for which he received chemotherapy with clinical deterioration. Even on extensive meticulous search, no primary was discovered.

[Metastasis revealing malignant peritoneum mesothelioma: About the difficulty to identify the primary tumors].

PubMed

Bretagne, Charles-Henri; Petitjean, Alain; Felix, Sophie; Bedgedjian, Isabelle; Algros, Marie-Paule; Delabrousse, Eric; Valmary-Degano, Séverine

2016-04-01

Peritoneal malignant mesothelioma is a rare and extremely aggressive tumor that is sometimes difficult to diagnose. We report two cases of metastatic malignant peritoneal mesothelioma. In one case, malignant metastatic cells were identified in cervical lymph nodes while in the other case, the cells were found in the liver. In both cases, metastases were identified before discovering the primary tumor. This led to the misdiagnosis of carcinoma of unknown origin. Nevertheless, the histological and immuno-histochemical patterns were typical of malignant mesothelioma. Regarding metastasis of unknown origin, a differentiation of epithelioid peritoneal malignant mesothelioma and adenocarcinoma proved to be difficult. Therefore, we discuss the diagnostic usefulness of immuno-histochemical mesothelioma markers. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Linking groundwater pollution to the decay of 15th-century sculptures in Burgos Cathedral (northern Spain).

PubMed

Gázquez, Fernando; Rull, Fernando; Medina, Jesús; Sanz-Arranz, Aurelio; Sanz, Carlos

2015-10-01

Precipitation of salts-mainly hydrated Mg-Na sulfates-in building materials is rated as one of the most severe threats to the preservation of our architectural and cultural heritage. Nevertheless, the origin of this pathology is still unknown in many cases. Proper identification of the cause of damage is crucial for correct planning of future restoration actions. The goal of this study is to identify the source of the degradation compounds that are affecting the 15th-century limestone sculptures that decorate the retro-choir of Burgos Cathedral (northern Spain). To this end, detailed characterization of minerals by in situ (Raman spectroscopy) and laboratory techniques (XRD, Raman and FTIR) was followed by major elements (ICP and IC) and isotopic analysis (δ(34)S and δ(15)N) of both the mineral phases precipitated on the retro-choir and the dissolved salts in groundwater in the vicinity of the cathedral. The results reveal unequivocal connection between the damage observed and capillary rise of salts-bearing water from the subsoil. The multianalytical methodology used is widely applicable to identify the origin of common affections suffered by historical buildings and masterpieces.

The Evolutionary History and Diverse Physiological Roles of the Grapevine Calcium-Dependent Protein Kinase Gene Family

PubMed Central

Chen, Fei; Fasoli, Marianna; Tornielli, Giovanni Battista; Dal Santo, Silvia; Pezzotti, Mario; Zhang, Liangsheng; Cai, Bin; Cheng, Zong-Ming

2013-01-01

Calcium-dependent protein kinases (CDPKs) are molecular switches that bind Ca2+, ATP, and protein substrates, acting as sensor relays and responders that convert Ca2+ signals, created by developmental processes and environmental stresses, into phosphorylation events. The precise functions of the CDPKs in grapevine (Vitis vinifera) are largely unknown. We therefore investigated the phylogenetic relationships and expression profiles of the 17 CDPK genes identified in the 12x grapevine genome sequence, resolving them into four subfamilies based on phylogenetic tree topology and gene structures. The origins of the CDPKs during grapevine evolution were characterized, involving 13 expansion events. Transcriptomic analysis using 54 tissues and developmental stages revealed three types of CDPK gene expression profiles: constitutive (housekeeping CDPKs), partitioned functions, and prevalent in pollen/stamen. We identified two duplicated CDPK genes that had evolved from housekeeping to pollen-prevalent functions and whose origin correlated with that of seed plants, suggesting neofunctionalization with an important role in pollen development and also potential value in the breeding of seedless varieties. We also found that CDPKs were involved in three abiotic stress signaling pathways and could therefore be used to investigate the crosstalk between stress responses. PMID:24324631

The Mineralogy of Martian Dust: Design and Analysis Considerations for an X-Ray Diffraction/X-Ray Fluorescence (XRD/XRF) Instrument for Exobiological Studies

NASA Technical Reports Server (NTRS)

Blake, David; Vaniman, David; Bish, David; Morrison, David (Technical Monitor)

1994-01-01

A principal objective of Mars exploration is the search for evidence of past life which may have existed during an earlier clement period of Mars history. We would like to investigate the history of surface water activity (which is a requirement for all known forms of life) by identifying and documenting the distribution of minerals which require water for their formation or distribution. A knowledge of the mineralogy of the present Martian surface would help to identify areas which, due to the early activity of water, might have harbored ancient life. It would be desirable to establish the presence and characterize the distribution of hydrated minerals such as clays, and of minerals which are primarily of sedimentary origin such as carbonates, silica and evaporites. Mineralogy, which is more critical to exobiological exploration than is simple chemical analysis (absent the detection of organics), will remain unknown or will at best be imprecisely constrained unless a technique sensitive to mineral structure such as powder X-ray diffraction (XRD) is employed. Additional information is contained in the original extended abstract.

Insect flight on fluid interfaces: a chaotic interfacial oscillator

NASA Astrophysics Data System (ADS)

Mukundarajan, Haripriya; Prakash, Manu

2013-11-01

Flight is critical to the dominance of insect species on our planet, with about 98 percent of insect species having wings. How complex flight control systems developed in insects is unknown, and arboreal or aquatic origins have been hypothesized. We examine the biomechanics of aquatic origins of flight. We recently reported discovery of a novel mode of ``2D flight'' in Galerucella beetles, which skim along an air-water interface using flapping wing flight. This unique flight mode is characterized by a balance between capillary forces from the interface and biomechanical forces exerted by the flapping wings. Complex interactions on the fluid interface form capillary wave trains behind the insect, and produce vertical oscillations at the surface due to non-linear forces arising from deformation of the fluid meniscus. We present both experimental observations of 2D flight kinematics and a dynamic model explaining the observed phenomena. Careful examination of this interaction predicts the chaotic nature of interfacial flight and takeoff from the interface into airborne flight. The role of wingbeat frequency, stroke plane angle and body angle in determining transition between interfacial and fully airborne flight is highlighted, shedding light on the aquatic theory of flight evolution.

Yessotoxins, a Group of Marine Polyether Toxins: an Overview

PubMed Central

Paz, Beatriz; Daranas, Antonio H.; Norte, Manuel; Riobó, Pilar; Franco, José M.; Fernández, José J.

2008-01-01

Yessotoxin (YTX) is a marine polyether toxin that was first isolated in 1986 from the scallop Patinopecten yessoensis. Subsequently, it was reported that YTX is produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. YTXs have been associated with diarrhetic shellfish poisoning (DSP) because they are often simultaneously extracted with DSP toxins, and give positive results when tested in the conventional mouse bioassay for DSP toxins. However, recent evidence suggests that YTXs should be excluded from the DSP toxins group, because unlike okadaic acid (OA) and dinophyisistoxin-1 (DTX-1), YTXs do not cause either diarrhea or inhibition of protein phosphatases. In spite of the increasing number of molecular studies focused on the toxicity of YTX, the precise mechanism of action is currently unknown. Since the discovery of YTX, almost forty new analogues isolated from both mussels and dinoflagellates have been characterized by NMR or LC-MS/MS techniques. These studies indicate a wide variability in the profile and the relative abundance of YTXs in both, bivalves and dinoflagellates. This review covers current knowledge on the origin, producer organisms and vectors, chemical structures, metabolism, biosynthetic origin, toxicological properties, potential risks to human health and advances in detection methods of YTXs. PMID:18728761

Yessotoxins, a group of marine polyether toxins: an overview.

PubMed

Paz, Beatriz; Daranas, Antonio H; Norte, Manuel; Riobó, Pilar; Franco, José M; Fernández, José J

2008-05-07

Yessotoxin (YTX) is a marine polyether toxin that was first isolated in 1986 from the scallop Patinopecten yessoensis. Subsequently, it was reported that YTX is produced by the dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. YTXs have been associated with diarrhetic shellfish poisoning (DSP) because they are often simultaneously extracted with DSP toxins, and give positive results when tested in the conventional mouse bioassay for DSP toxins. However, recent evidence suggests that YTXs should be excluded from the DSP toxins group, because unlike okadaic acid (OA) and dinophyisistoxin-1 (DTX-1), YTXs do not cause either diarrhea or inhibition of protein phosphatases. In spite of the increasing number of molecular studies focused on the toxicity of YTX, the precise mechanism of action is currently unknown. Since the discovery of YTX, almost forty new analogues isolated from both mussels and dinoflagellates have been characterized by NMR or LC-MS/MS techniques. These studies indicate a wide variability in the profile and the relative abundance of YTXs in both, bivalves and dinoflagellates. This review covers current knowledge on the origin, producer organisms and vectors, chemical structures, metabolism, biosynthetic origin, toxicological properties, potential risks to human health and advances in detection methods of YTXs.

11. Photographic copy of photograph, photographer unknown, 2 July 1938 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photographic copy of photograph, photographer unknown, 2 July 1938 (original print located at U.S. Bureau of Reclamation Upper Columbia Area Office, Yakima, Washington). "Inspecting concrete on upstream face of Keechelus Dam spillway. Joseph Jacobs, consulting engineer; M.B. Lemon, Gatetender; Paul Taylor, assistant engineer; and C.H. Paul, consulting engineer." - Keechelus Dam, Spillway, Yakim River, 10 miles northwest of Easton, Easton, Kittitas County, WA

Iron overload patients with unknown etiology from national survey in Japan.

PubMed

Ikuta, Katsuya; Hatayama, Mayumi; Addo, Lynda; Toki, Yasumichi; Sasaki, Katsunori; Tatsumi, Yasuaki; Hattori, Ai; Kato, Ayako; Kato, Koichi; Hayashi, Hisao; Suzuki, Takahiro; Kobune, Masayoshi; Tsutsui, Miyuki; Gotoh, Akihiko; Aota, Yasuo; Matsuura, Motoo; Hamada, Yuzuru; Tokuda, Takahiro; Komatsu, Norio; Kohgo, Yutaka

2017-03-01

Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan has not been fully investigated. In the present study, we obtained and studied detailed clinical information on the iron overload patient population in Japan. Of 1109 iron overload cases, 93.1% were considered to have occurred post-transfusion. There were, however, 76 cases of iron overload of unknown origin, which suggest that many clinicians in Japan may encounter some difficulty in correctly diagnosing and treating iron overload. Further clinical data were obtained for 32 cases of iron overload of unknown origin; median of serum ferritin was 1860.5 ng/mL. As occurs in post-transfusional iron overload, liver dysfunction was found to be as high as 95.7% when serum ferritin levels exceeded 1000 ng/mL in these patients. Gene mutation analysis of the iron metabolism-related genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.

Leaping into the Unknown: Developing Thinking in the Primary Science Classroom

ERIC Educational Resources Information Center

Serret, Natasha

2004-01-01

The original project, the foundation for all subsequent work, was set up in 1981 by Michael Shayer, with Philip Adey and Carolyn Yates, and became known as CASE @ KS3 (Adey and Shayer, 1994). CASE stands for Cognitive Acceleration through Science Education. The original CASE project drew on Piaget's work on the stage theory of cognitive…

12. Photocopy of photograph (original photograph in possession of 30th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of photograph (original photograph in possession of 30th Audiovisual Squadron, Vandenberg Air Force Base, California). Photography by United States Air Force, date unknown. LAUNCH OF AN ATLAS FROM SLC-3. MOBILE SERVICE TOWER (MST) IN PARKED POSITION. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

42. Photocopy of photograph (negative made from original photograph displayed ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Photocopy of photograph (negative made from original photograph displayed in office at Veterans Administration in Wichita, Kansas), photographer unknown, ca. 1935. Panoramic of campus, view of north and east, Building 8 is first structure on right - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

43. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photographic copy of photograph (ca. 1962, original print in possession of Peter Kiewit Sons' Co., Omaha, Nebraska) Photographer unknown. View of launch closure, launch closure apron at left, personnel access hatch open at right - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

84. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

84. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. ROCK CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; WEST VIEW OF SIPHON PIPE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

85. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

85. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. ROCK CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; EAST VIEW OF SIPHON PIPE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

83. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

83. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. DRY CREEK GATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; GATES FROM THE LOWER SIDE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

12. Photocopy of photograph (original photograph in possession of Atlanta ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of photograph (original photograph in possession of Atlanta Housing Authority, Atlanta, GA). Photographer unknown, circa 1945. View across park and playground between Techwood Homes and Clark Howell Homes, facing west with Clark Howell Homes in background. - Clark Howell Homes (Public Housing), Bounded by North Avenue, Lovejoy Street, Mills Street & Luckie Street, Atlanta, Fulton County, GA

12. Photocopy of antique postcard. (Original postcard is in the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of antique postcard. (Original postcard is in the possession of the Venice Branch of the Los Angeles Public Library, publisher/photographer unknown.) VIEW OF PRE-EXISTING GRAND CANAL COURT PEDESTRIAN BRIDGE OVER CARROLL CANAL, LOOKING EAST TOWARD DELL AVENUE VEHICULAR BRIDGE - Venice Canals, Community of Venice, Los Angeles, Los Angeles County, CA

9. Photographic copy of photograph (circa 1908, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photographic copy of photograph (circa 1908, original print in Archives, Public Affairs Department, Sears Merchandise Group, Hoffman Estates, Illinois), Photographer unknown. OVERALL VIEW OF PRINTING AND ADVERTISING BUILDING, ADMINISTRATION BUILDING, AND MERCHANDISE BUILDING, VIEW TO WEST-SOUTHWEST - Sears Roebuck & Company Mail Order Plant, Bounded by Lexington & Grenshaw Streets, Kedzie Avenue & Independence Boulevard, Chicago, Cook County, IL

130. Photographic copy of drawing (undated, original drawing in Archives, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

130. Photographic copy of drawing (undated, original drawing in Archives, Public Affairs Department, Sears Merchandise Group, Hoffman Estates, Illinois). Engineer unknown. Full size. Pneumatic tube cartridges used at the time of the Plant closing. 4' PNEUMATIC TUBE SYSTEM - 11' LEATHER CARRIER - Sears Roebuck & Company Mail Order Plant, Merchandise Building, 924 South Homan Avenue, Chicago, Cook County, IL

131. Photographic copy of drawing (undated, original drawing in Archives, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

131. Photographic copy of drawing (undated, original drawing in Archives, Public Affairs Department, Sears Merchandise Group, Hoffman Estates, Illinois). Engineer unknown. Full size. Pneumatic tube cartridges used at the time of the Plant closing. 4' PNEUMATIC TUBE SYSTEM - 11' LEATHER CARRIER - Sears Roebuck & Company Mail Order Plant, Merchandise Building, 924 South Homan Avenue, Chicago, Cook County, IL

Earth observations taken by the STS-9 crew

NASA Image and Video Library

2009-06-25

STS009-35-1622 (28 Nov-8 Dec 1983) --- In the Coral Sea to the last of Australia?s Great Barrier Reed, a massive area is covered with floating material. Its origin is presently unknown nor is it known to be of biological origin or man-made. However, it covers thousands of square miles, thus massive, and is unreported.

25. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative VIEW OF THE NORTH END OF THE OLD TIMBER DAM AT DAM SITE No. 3 - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

15. Photocopy of photograph (original 43/4 x 33/4 inch print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of photograph (original 4-3/4 x 3-3/4 inch print located in the Recreation files, Mt. Baker-Snoqualmie N. F.). Photographer unknown, ca. 1941 SKI WARMING HUT, AUSTIN PASS, GLACIER DISTRICT. (NOTE PLANK SPANNING GAP BETWEEN KNOLL AND PORCH) - Austin Pass Warming Hut, Washington Highway 542, Glacier, Whatcom County, WA

The avian-origin H3N2 canine influenza virus has limited replication in swine

USDA-ARS?s Scientific Manuscript database

A genetically and antigenically distinct H3N2 canine influenza of avian-origin was detected in March of 2015 in Chicago, Illinois. A subsequent outbreak was reported with over 1,000 dogs in the Midwest affected. The potential for canine-to-swine transmission was unknown. Experimental infection in pi...

35. Photographic copy of historic photo, c1915 (original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

35. Photographic copy of historic photo, c1915 (original print in Still Photo Branch of the National Archives, RG-155-JC, Washington, DC; photographer unknown). FRONT VIEW OF BOISE PROJECT OFFICE SHOWING UNITED STATES RECLAMATION SERVICE BOISE PROJECT CLERICAL AND ENGINEERING STAFF. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID

Radiation therapy in the management of head-and-neck cancer of unknown primary origin: how does the addition of concurrent chemotherapy affect the therapeutic ratio?

PubMed

Chen, Allen M; Farwell, D Gregory; Lau, Derick H; Li, Bao-Qing; Luu, Quang; Donald, Paul J

2011-10-01

To determine how the addition of cisplatin-based concurrent chemotherapy to radiation therapy influences outcomes among a cohort of patients treated for head-and-neck cancer of unknown primary origin. The medical records of 60 consecutive patients treated by radiation therapy for squamous cell carcinoma of the head and neck presenting as cervical lymph node metastasis of occult primary origin were reviewed. Thirty-two patients (53%) were treated by concurrent chemoradiation, and 28 patients (47%) were treated by radiation therapy alone. Forty-five patients (75%) received radiation therapy after surgical resection, and 15 patients (25%) received primary radiation therapy. Thirty-five patients (58%) were treated by intensity-modulated radiotherapy. The 2-year estimates of overall survival, local-regional control, and progression-free survival were 89%, 89%, and 79%, respectively, among patients treated by chemoradiation, compared to 90%, 92%, and 83%, respectively, among patients treated by radiation therapy alone (p > 0.05, for all). Exploratory analysis failed to identify any subset of patients who benefited from the addition of concurrent chemotherapy to radiation therapy. The use of concurrent chemotherapy was associated with a significantly increased incidence of Grade 3+ acute and late toxicity (p < 0.001, for both). Concurrent chemoradiation is associated with significant toxicity without a clear advantage to overall survival, local-regional control, and progression-free survival in the treatment of head-and-neck cancer of unknown primary origin. Although selection bias cannot be ignored, prospective data are needed to further address this question. Copyright © 2011 Elsevier Inc. All rights reserved.

An improved methodology of asymmetric flow field flow fractionation hyphenated with inductively coupled mass spectrometry for the determination of size distribution of gold nanoparticles in dietary supplements.

PubMed

Mudalige, Thilak K; Qu, Haiou; Linder, Sean W

2015-11-13

Engineered nanoparticles are available in large numbers of commercial products claiming various health benefits. Nanoparticle absorption, distribution, metabolism, excretion, and toxicity in a biological system are dependent on particle size, thus the determination of size and size distribution is essential for full characterization. Number based average size and size distribution is a major parameter for full characterization of the nanoparticle. In the case of polydispersed samples, large numbers of particles are needed to obtain accurate size distribution data. Herein, we report a rapid methodology, demonstrating improved nanoparticle recovery and excellent size resolution, for the characterization of gold nanoparticles in dietary supplements using asymmetric flow field flow fractionation coupled with visible absorption spectrometry and inductively coupled plasma mass spectrometry. A linear relationship between gold nanoparticle size and retention times was observed, and used for characterization of unknown samples. The particle size results from unknown samples were compared to results from traditional size analysis by transmission electron microscopy, and found to have less than a 5% deviation in size for unknown product over the size range from 7 to 30 nm. Published by Elsevier B.V.

Sliding Mode Observer-Based Current Sensor Fault Reconstruction and Unknown Load Disturbance Estimation for PMSM Driven System.

PubMed

Zhao, Kaihui; Li, Peng; Zhang, Changfan; Li, Xiangfei; He, Jing; Lin, Yuliang

2017-12-06

This paper proposes a new scheme of reconstructing current sensor faults and estimating unknown load disturbance for a permanent magnet synchronous motor (PMSM)-driven system. First, the original PMSM system is transformed into two subsystems; the first subsystem has unknown system load disturbances, which are unrelated to sensor faults, and the second subsystem has sensor faults, but is free from unknown load disturbances. Introducing a new state variable, the augmented subsystem that has sensor faults can be transformed into having actuator faults. Second, two sliding mode observers (SMOs) are designed: the unknown load disturbance is estimated by the first SMO in the subsystem, which has unknown load disturbance, and the sensor faults can be reconstructed using the second SMO in the augmented subsystem, which has sensor faults. The gains of the proposed SMOs and their stability analysis are developed via the solution of linear matrix inequality (LMI). Finally, the effectiveness of the proposed scheme was verified by simulations and experiments. The results demonstrate that the proposed scheme can reconstruct current sensor faults and estimate unknown load disturbance for the PMSM-driven system.

Fever of unknown origin: analysis of 71 consecutive cases.

PubMed

Colpan, Aylin; Onguru, Pinar; Erbay, Ayse; Akinci, Esragul; Cevik, Mustafa Aydin; Eren, Selim Sirri; Bodur, Hurrem

2007-08-01

Fever of unknown origin (FUO) is still an important problem in clinical practice. Evaluation of patient characteristics may clarify the utility of diagnostic tests and etiologies of FUO. Fever of unknown origin in 71 patients was investigated at Ankara Numune Education and Research Hospital in Turkey between February 2001 and December 2004. Mean hospital stay and fever duration was 20.5 days and 44 days, respectively. Etiologies of FUO were as follows: infections 32 (45.1%), collagen vascular disease 19 (26.8%), neoplasm 10 (14.1%), and miscellaneous diseases 4 (5.6%). Diagnosis remained obscure in 6 patients (8.5 %). Tuberculosis was found to be 40% of the infectious causes of FUO. Mean hospital stay and fever duration were prolonged in infectious cases. Female predominance was observed in collagen vascular diseases (P = 0.047). Splenomegaly and lymphadenopathy were common in the neoplasm group (P = 0.017, P = 0.017, respectively). Erythrocyte sedimentation rate, aspartate aminotransferase, alanine aminotransferase and lactate hydrogenase levels were elevated in patients with collagen vascular diseases. Nine (12.7%) patients died during the follow-up period. Hospital stay and fever duration were prolonged in the infectious group of FUO patients. Infectious diseases, particularly tuberculosis, were the most important cause of FUO in our series. Tuberculosis should be kept in mind as an important etiology of FUO countries where tuberculosis is endemic.

Does magnetic resonance imaging produce further benefit for detecting a bleeding source in subarachnoid hemorrhage of unknown origin?

PubMed

Maslehaty, Homajoun; Petridis, Athanassios K; Barth, Harald; Doukas, Alexandros; Mehdorn, Hubertus Maximilian

2011-01-01

Spontaneous subarachnoid hemorrhage (SAH) without evidence of a bleeding source on the first digital subtraction angiogram (DSA) - also called SAH of unknown origin - is observed in up to 27% of all cases. Depending on the bleeding pattern on CT scanning, SAH can be differentiated into perimesencephalic (PM-SAH) and non-perimesencephalic SAH (NON-PM-SAH). The aim of our study was to investigate the effectiveness of magnetic resonance imaging (MRI) for detecting a bleeding source in SAH of unknown origin. We retrospectively reviewed 1,226 patients with spontaneous SAH between January 1991 and December 2008 in our department. DSA was performed in 1,068 patients, with negative results in 179 patients. Forty-seven patients were categorized as having PM-SAH and 132 patients as having NON-PM-SAH. MRI of the brain and the craniocervical region was performed within 72 h after diagnosis of SAH and demonstrated no bleeding sources in any of the PM-SAH and NON-PM-SAH patients (100% negative). In our experience MRI did not produce any additional benefit for detecting a bleeding source after SAH with a negative angiogram. The costs of this examination exceeded the clinical value. Despite our results MRI should be discussed on a case-by-case basis because rare bleeding sources are periodically diagnosed in cases of NON-PM-SAH.

Unintentional drinking-water contamination events of unknown origin: surrogate for terrorism preparedness.

PubMed

Winston, Gary; Leventhal, Alex

2008-01-01

Drinking-water is a direct conduit to many human receptors. An intentional attack (e.g. terrorism) on drinking-water systems can shock and disrupt elements of national infrastructures. We report on an unintentional drinking-water contamination event that occurred in Tel Aviv, Israel in July, 2001. Initially of unknown origin, this event involved risk management strategies used by the Ministry of Health for abating a potential public health crisis as might be envisaged of water contamination due to terrorism. In an abrupt event of unknown origin, public health officials need to be responsible for the same level of preparedness and risk communication. This is emphasized by comparison of management strategies between the Tel Aviv event and one of dire consequences that occurred in Camelford, England in 1988. From the onset of the Tel Aviv incident, the public health strategy was to employ the precautionary principle by warning residents of the affected region to not drink tap water, even if boiled. This strategy was in contrast to an earlier crisis that occurred in Camelford, England in 1988. An outcome of this event was heightened awareness that a water crisis can occur in peacetime and not only in association with terrorism. No matter how minor the contamination event or short-term the disruption of delivery of safe drinking-water, psychological, medical and public health impact could be significant.

[Chronic lymphocytic leukaemia: current management].

PubMed

Aurran-Schleinitz, T; Arnoulet, C; Ivanov, V; Coso, D; Rey, J; Schiano, J-M; Stoppa, A-M; Bouabdallah, R; Gastaut, J-A

2008-05-01

Chronic lymphocytic leukemia (CLL) is the most common leukaemia in the Western world. Recent advancement in the aetiology, pathophysiology and the development of new therapeutics tools have significantly modified the current management of CLL. The cellular origin of CLL is still unknown. The current main hypothesis will be first briefly described. This review will then focus on the newly defined prognostic factors and the development and use of new drugs for the treatment of CLL. To describe the modern and practical management of CLL, we will compare classical and new prognostic markers. Then, we will discuss the various therapeutic options including chemotherapy and immunotherapy (monoclonal antibodies, allogenic transplantation), and define their current respective indications. These new diagnostic and prognostic markers will allow the characterization of new prognostic subgroups of patients. This will lead to a targeted and individualized therapeutic approach. We will present the first results of clinical trials and the on-going studies conducted in this disease.

Gamma delta T-cell large granular lymphocyte lymphoma in a dog.

PubMed

Ortiz, Ana Liza; Carvalho, Sofia; Leo, Chiara; Riondato, Fulvio; Archer, Joy; Cian, Francesco

2015-09-01

A 2-year and 6-month-old female neutered Labrador Retriever with Horner syndrome, megaesophagus, and a mediastinal mass was referred to the Queen Mother Hospital for Animals of the Royal Veterinary College. A large granular lymphocyte (LGL) lymphoma was diagnosed on cytology; flow cytometric analysis revealed a γδ T-cell phenotype (CD3+, CD5+, CD45+, TCRγδ+, CD4-, CD8-, CD34-, CD21-). Chemotherapy was started with a combination of lomustine, vincristine, procarbazine, and prednisolone, followed by bleyomicin. Euthanasia was elected by the owners, due to progressive deterioration and lack of quality of life, 28 days after diagnosis. This is the first cytologic and immunophenotypic characterization of a canine γδ T-cell lymphoma with LGL morphology and probably of mediastinal origin. The role of chemotherapy in delaying the disease progression remains unknown. © 2015 American Society for Veterinary Clinical Pathology.

[A case of iatrogenic scrotal elephantiasis: reconstruction of the scrotal purse and the cutaneous sleeve of the penis with local skin flaps].

PubMed

Masia, D-R; Castus, P; Delia, G; Casoli, V; Martine, D

2008-02-01

Scrotal elephantiasis is a pathology of often unknown etiology. Symptomatology is characterized by an oedematius infiltration of skin and subcutaneous tissue, hard-bound aspect and purplished color. The scrotum, the penis and the perineal area are gradually affected. This pathology is very invalidating for the patient, on functional, sexual and aesthetic aspects. The authors present the case of a 58-year-old man with an enormous scrotal mass invading the penis and drowning the testicular elements, which were impossible to palpate. The aetiology was determined by exclusion and an iatrogenic origin following the cure of bilateral inguinal hernia was retained. Resection of the scrotal mass was performed. The reconstruction of the scrotal purse and the cutaneous sleeve of the penis were carried out using local flaps of the remaining healthy skin.

In vitro prebiotic effects of seaweed polysaccharides

NASA Astrophysics Data System (ADS)

Chen, Xiaolin; Sun, Yuhao; Hu, Linfeng; Liu, Song; Yu, Huahua; Xing, Rong'e.; Li, Rongfeng; Wang, Xueqin; Li, Pengcheng

2017-09-01

Although prebiotic activities of alginate and agar oligosaccharides isolated from seaweeds have been reported, it remains unknown whether seaweed polysaccharides have prebiotic activity. In this study, we isolated polysaccharides from four species of seaweeds, such as Grateloupia filicina (GFP), Eucheuma spinosum (ESP), Ulva pertusa (UPP), and Ascophyllum nodosum (ANP), and characterized their structures and prebiotic effects in vitro. The results showed that these polysaccharides were different in total sugar and sulfate contents as well as monosaccharide composition. GFP and ESP significantly promoted bifidobacterium proliferation and 0.1% ESP and 0.4% GFP resulted in the highest proliferation rates of beneficial bacteria, whereas UPP and ANP inhibited the growth of beneficial bacteria at all tested concentrations (0.1%-0.5%). The different behaviors of the four seaweed-originated polysaccharides might be reflected by differences in monosaccharide composition and structure. Therefore, polysaccharides isolated from GFP and ESP could be utilized as prebiotics. However, more studies must be carried out in vivo.

Evidence from animal models on the pathogenesis of PCOS.

PubMed

Walters, K A; Bertoldo, M J; Handelsman, D J

2018-06-01

Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women, and is characterized by reproductive, endocrine and metabolic features. However, there is no simple unequivocal diagnostic test for PCOS, its etiology remains unknown and there is no cure. Hence, the management of PCOS is suboptimal as it relies on the ad hoc empirical management of its symptoms only. Decisive studies are required to unravel the origins of PCOS, but due to ethical and logistical reasons these are not possible in humans. Experimental animal models for PCOS have been established which have enhanced our understanding of the mechanisms underlying PCOS and propose novel mechanism-based therapies to treat the condition. This review examines the findings from various animal models to reveal the current knowledge of the mechanisms underpinning the development of PCOS, and also provides insights into the implications from these studies for improved clinical management of this disorder. Copyright © 2018 Elsevier Ltd. All rights reserved.

Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen

PubMed Central

Blyth, Julie; Makrantoni, Vasso; Barton, Rachael E.; Spanos, Christos; Rappsilber, Juri; Marston, Adele L.

2018-01-01

Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways important for meiosis, but the parts list is still poorly defined. Here we present a comprehensive catalog of genes important for meiosis in the fission yeast, Schizosaccharomyces pombe. Our genome-wide functional screen surveyed all nonessential genes for roles in chromosome segregation and spore formation. Novel genes important at distinct stages of the meiotic chromosome segregation and differentiation program were identified. Preliminary characterization implicated three of these genes in centrosome/spindle pole body, centromere, and cohesion function. Our findings represent a near-complete parts list of genes important for meiosis in fission yeast, providing a valuable resource to advance our molecular understanding of meiosis. PMID:29259000

[Burning sensation in oral cavity--burning mouth syndrome in everyday medical practice].

PubMed

Gerlinger, Imre

2012-09-30

Burning mouth syndrome (BMS) refers to chronic orofacial pain, unaccompanied by mucosal lesions or other evident clinical signs. It is observed principally in middle-aged patients and postmenopausal women. BMS is characterized by an intense burning or stinging sensation, typically on the tongue or in other areas of the oral mucosa. It can be accompanied by other sensory disorders such as dry mouth or taste alterations. Probably of multifactorial origin, and often idiopathic, with a still unknown etiopathogenesis in which local, systemic and psychological factors are implicated. Currently there is no consensus on the diagnosis and classification of BMS. This study reviews the literature on this syndrome, with special reference to the etiological factors that may be involved and the clinical aspects they present. The diagnostic criteria that should be followed and the therapeutic management are discussed with reference to the most recent studies.

Laspartomycin, an acidic lipopeptide antibiotic with a unique peptide core.

PubMed

Borders, Donald B; Leese, Richard A; Jarolmen, Howard; Francis, Noreen D; Fantini, Amadeo A; Falla, Tim; Fiddes, John C; Aumelas, André

2007-03-01

Laspartomycin was originally isolated and characterized in 1968 as a lipopeptide antibiotic related to amphomycin. The molecular weight and structure remained unknown until now. In the present study, laspartomycin was purified by a novel calcium chelate procedure, and the structure of the major component (1) was determined. The structure of laspartomycin C (1) differs from that of amphomycin and all related antibiotics as a result of its peptide region being acidic rather than amphoteric and the amino acid branching into the side chain being diaminopropionic rather than diaminobutyric. In addition, the fatty acid side chain is 2,3-unsaturated compared to 3,4-unsaturated for amphomycin and other related antibiotics. Calcium ion addition to stabilize a particular conformer was found to be important for an enzymatic deacylation of the antibiotic. A peptide resulting from the deacylation was critical for chemical structure determination by NMR studies, which also involved addition of calcium ions to stabilize a conformer.

On the origin of the moon, with emphasis on bulk composition

NASA Technical Reports Server (NTRS)

Kaula, W. M.

1977-01-01

A new analysis of altimetric, gravimetric, and seismological results, together with petrological and thermal history constraints, obtains an estimated Al2O3 content of 5.0%, 2.1 times chondritic. Hence the moon definitely has a refractory lithophile excess as well as an iron deficiency. In addition, the lunar surface is characterized by refractory siderophile depletions. The combination of these properties appears to require a previous stage of differentiation in a planetary body or bodies. Siderophile and chalcolphile depletions and dispersions in eucrites suggest that these bodies are not necessarily large. Possible mechanisms of lunar formation include impacting of a very large body into the earth; tidal disruption of sizeable differentiated planetesimals by the earth; and selective capture of differentiated planetesimal material by small moonlets. Each mechanism has its difficulties; the major unknown affecting all of them is the size distribution of planetesimals.

[Small airway diseases and immune deficiency].

PubMed

Burgel, P-R; Bergeron, A; Knoop, C; Dusser, D

2016-02-01

Innate or acquired immune deficiency may show respiratory manifestations, often characterized by small airway involvement. The purpose of this article is to provide an overview of small airway disease across the major causes of immune deficiency. In patients with common variable immune deficiency, recurrent lower airway infections may lead to bronchiolitis and bronchiectasis. Follicular and/or granulomatous bronchiolitis of unknown origin may also occur. Bronchiolitis obliterans is the leading cause of death after the first year in patients with lung transplantation. Bronchiolitis obliterans also occurs in patients with allogeneic haematopoietic stem cell transplantation, especially in the context of systemic graft-versus-host disease. Small airway diseases have different clinical expression and pathophysiology across various causes of immune deficiency. A better understanding of small airways disease pathogenesis in these settings may lead to the development of novel targeted therapies. Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strickland, Madeleine; Stanley, Ann Marie; Wang, Guangshun

Paralogous enzymes arise from gene duplication events that confer a novel function, although it is unclear how cross-reaction between the original and duplicate protein interaction network is minimized. We investigated HPr:EIsugar and NPr:EINtr, the initial complexes of paralogous phosphorylation cascades involved in sugar import and nitrogen regulation in bacteria, respectively. Although the HPr:EIsugar interaction has been well characterized, involving multiple complexes and transient interactions, the exact nature of the NPr:EINtr complex was unknown. We set out to identify the key features of the interaction by performing binding assays and elucidating the structure of NPr in complex with the phosphorylation domainmore » of EINtr (EINNtr), using a hybrid approach involving X-ray, homology, and sparse nuclear magnetic resonance. We found that the overall fold and active-site structure of the two complexes are conserved in order to maintain productive phosphorylation, however, the interface surface potential differs between the two complexes, which prevents cross-reaction.« less

On Space Exploration and Human Error: A Paper on Reliability and Safety

NASA Technical Reports Server (NTRS)

Bell, David G.; Maluf, David A.; Gawdiak, Yuri

2005-01-01

NASA space exploration should largely address a problem class in reliability and risk management stemming primarily from human error, system risk and multi-objective trade-off analysis, by conducting research into system complexity, risk characterization and modeling, and system reasoning. In general, in every mission we can distinguish risk in three possible ways: a) known-known, b) known-unknown, and c) unknown-unknown. It is probably almost certain that space exploration will partially experience similar known or unknown risks embedded in the Apollo missions, Shuttle or Station unless something alters how NASA will perceive and manage safety and reliability

Carcinoma of unknown primary: key radiological issues from the recent National Institute for Health and Clinical Excellence guidelines

PubMed Central

Taylor, M B; Bromham, N R; Arnold, S E

2012-01-01

Carcinoma of unknown primary origin (CUP) accounts for 3–5% of cancer cases and is the fourth most common cause of cancer death in the UK. CUP management is challenging, partly owing to the heterogeneity of the condition and its presentation, but also owing to the lack of dedicated clinical services for these patients. The recent National Institute for Health and Clinical Excellence (NICE) guidelines on metastatic malignancy of unknown primary origin were developed to improve the co-ordination of diagnostic and clinical services at hospitals treating cancer patients in England and Wales, in particular by the setting up of CUP teams to manage these patients. Radiologists have a vital role in the diagnosis of these patients and should work closely with the CUP team to streamline the diagnostic pathway. This article summarises areas of the NICE guidelines relevant to radiology and discusses the radiological management of patients with CUP, including initial investigation, the importance of biopsy, the management of specific presentations, special investigations and organisational issues. PMID:22374278

11. Photocopy of photograph (original photograph in possession of Val ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photocopy of photograph (original photograph in possession of Val Brose, General Dynamics Space Systems Division, Vandenberg Air Force Base, California). Photographer unknown, circa July 1961. CREW OF FIRST LAUNCH FROM POINT ARGUELLO LAUNCH COMPLEX 1, PAD 2, (SLC-3E) ON LAUNCH PAD. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

165. Photocopy of Photograph (original in Roger Lewis' private collection). ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

165. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. MILNER DAM, TWIN FALLS COUNTY, MILNER IDAHO; CRANES USED TO PLACE ROCK ON DAM; NOTE ELECTRIC RAILROAD CAR AT LEFT. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

1. Photocopy of photograph (original print located in Pope & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of photograph (original print located in Pope & Talbot Archives Port Gamble, WA). Unknown Photographer, 1907. View of Gamble Bay, facing west from east shore. S'klallam Village of Boston in foreground, Puget Mill in background. - Port Gamble National Historic Landmark, Bounded by Hood Canal, Port Gamble Bay, State Road 104, & Town Limits, Port Gamble, Kitsap County, WA

82. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

82. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. DRY CREEK HEADGATES, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; CHECK GATES ACROSS THE MAIN CANAL BELOW DRY CREEK. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

161. Photocopy of Photograph (original in Roger Lewis' private collection, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

161. Photocopy of Photograph (original in Roger Lewis' private collection, Twin Falls, Idaho). Photographer and date unknown. MILNER DAM, SOUTH SIDE CANAL, TWIN FALLS COUNTY, MILNER, IDAHO; WORKERS AT CAMP AT HEAD OF CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

87. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

87. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. ROCK CREEK SIPHON, LOW LINE CANAL, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; UPPER END OF THE SIPHON. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

81. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

81. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. DRY CREEK DAM, TWIN FALLS COUNTY, SOUTH OF MURTAUGH, IDAHO; DRIVING SHEET PILING TO SHUT OFF SEEPAGE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

86. Photocopy of Photograph (original located in Univ. of Denver ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. Photocopy of Photograph (original located in Univ. of Denver collection). C.R. Savage, Photographer, date unknown. ROCK CREEK SIPHON, TWIN FALLS COUNTY, SOUTH OF KIMBERLY, IDAHO; MEN WORKING ON THE EAST END OF THE SIPHON. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

12. Photographic copy of photograph (circa 1920's, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photographic copy of photograph (circa 1920's, original print in Archives, Public Affairs Department, Sears Merchandise Group, Hoffman Estates, Illinois), Photographer unknown. OVERALL VIEW OF PRINTING AND ADVERTISING BUILDING, ADMINISTRATION BUILDING, AND MERCHANDISE BUILDING, VIEW TO SOUTHEAST - Sears Roebuck & Company Mail Order Plant, Bounded by Lexington & Grenshaw Streets, Kedzie Avenue & Independence Boulevard, Chicago, Cook County, IL

North American montane red foxes: expansion, fragmentation, and the origin of the Sacramento Valley red fox

Treesearch

Benjamin N. Sacks; Mark J. Statham; John D. Perrine; Samantha M. Wisely; Keith B. Aubry

2010-01-01

Most native red foxes (Vulpes vulpes) in the western contiguous United States appear to be climatically restricted to colder regions in the major mountain ranges and, in some areas, have suffered precipitous declines in abundance that may be linked to warming trends. However, another population of unknown origin has occurred in arid habitats in the...

Photographic copy of photograph, ca. 1919 (original print located in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photographic copy of photograph, ca. 1919 (original print located in the National Archives & Records Administration, Still Picture Branch, Panama Canal Collection Series 185-G, #352, Washington, D.C.). Photographer unknown. View of El Prado from administration building with Balboa Elementary School on left side, looking west. - Balboa School, Northeast end of El Prado, Balboa, Former Panama Canal Zone, CZ

19. Photographic copy of photograph (ca. 1962, original print in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photographic copy of photograph (ca. 1962, original print in possession of Peter Kiewit Sons' Co., Omaha, Nebraska) Photographer unknown. Road signs for Alpha Flight Launch Facility sites 8-11 and Bravo Flight Launch Facility sites 2 and 11 - Ellsworth Air Force Base, Delta Flight, 10 mile radius around Exit 127 off Interstate 90, Interior, Jackson County, SD

31. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

31. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1934, photographer unknown 3 1/4 X 4 5/8 inch negative EAST END OF THE TIMBER CRIB DAM AT THE GRIST MILL (right) AND THE SAW MILL (center). - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

21. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative BUILDING OF DAM No. 3, LOOKING EAST FROM THE NORTH BANK, SHOWING THE WOODEN FORMWORK FOR THE CONCRETE DAM - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

26. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative GENERAL VIEW OF THE POND OF DAM No.4. THE OLD TIMBER CRIB DAM No. 3 IS VISIBLE IN THE BACKGROUND - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

22. Photocopy of original photo from Corps of Engineers, Los ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

22. Photocopy of original photo from Corps of Engineers, Los Angeles District, 'Report on Salinas Dam, Salinas River, California,' June 15, 1943. (Photographer unknown; report located at City of San Luis Obispo.) CONSTRUCTION PHOTO SHOWING THE STRUTS, POURED TO ALIGN WITH THE RIGHT (WEST) BUTTRESS. - Salinas Dam, Salinas River near Pozo Road, Santa Margarita, San Luis Obispo County, CA

Multiple and asymmetrical origin of polyploid dog rose hybrids (Rosa L. sect. Caninae (DC.) Ser.) involving unreduced gametes.

PubMed

Herklotz, V; Ritz, C M

2017-08-01

Polyploidy and hybridization are important factors for generating diversity in plants. The species-rich dog roses ( Rosa sect. Caninae ) originated by allopolyploidy and are characterized by unbalanced meiosis producing polyploid egg cells (usually 4 x ) and haploid sperm cells (1 x ). In extant natural stands species hybridize spontaneously, but the extent of natural hybridization is unknown. The aim of the study was to document the frequency of reciprocal hybridization between the subsections Rubigineae and Caninae with special reference to the contribution of unreduced egg cells (5 x ) producing 6 x offspring after fertilization with reduced (1 x ) sperm cells. We tested whether hybrids arose by independent multiple events or via a single or few incidences followed by a subsequent spread of hybrids. Population genetics of 45 mixed stands of dog roses across central and south-eastern Europe were analysed using microsatellite markers and flow cytometry. Hybrids were recognized by the presence of diagnostic alleles and multivariate statistics were used to display the relationships between parental species and hybrids. Among plants classified to subsect. Rubigineae , 32 % hybridogenic individuals were detected but only 8 % hybrids were found in plants assigned to subsect. Caninae . This bias between reciprocal crossings was accompanied by a higher ploidy level in Rubigineae hybrids, which originated more frequently by unreduced egg cells. Genetic patterns of hybrids were strongly geographically structured, supporting their independent origin. The biased crossing barriers between subsections are explained by the facilitated production of unreduced gametes in subsect. Rubigineae . Unreduced egg cells probably provide the highly homologous chromosome sets required for correct chromosome pairing in hybrids. Furthermore, the higher frequency of Rubigineae hybrids is probably influenced by abundance effects because the plants of subsect. Caninae are much more abundant and thus provide large quantities of pollen. Hybrids are formed spontaneously, leading to highly diverse mixed stands, which are insufficiently characterized by the actual taxonomy. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Integrative metabolomics for characterizing unknown low-abundance metabolites by capillary electrophoresis-mass spectrometry with computer simulations.

PubMed

Lee, Richard; Ptolemy, Adam S; Niewczas, Liliana; Britz-McKibbin, Philip

2007-01-15

Characterization of unknown low-abundance metabolites in biological samples is one the most significant challenges in metabolomic research. In this report, an integrative strategy based on capillary electrophoresis-electrospray ionization-ion trap mass spectrometry (CE-ESI-ITMS) with computer simulations is examined as a multiplexed approach for studying the selective nutrient uptake behavior of E. coli within a complex broth medium. On-line sample preconcentration with desalting by CE-ESI-ITMS was performed directly without off-line sample pretreatment in order to improve detector sensitivity over 50-fold for cationic metabolites with nanomolar detection limits. The migration behavior of charged metabolites were also modeled in CE as a qualitative tool to support MS characterization based on two fundamental analyte physicochemical properties, namely, absolute mobility (muo) and acid dissociation constant (pKa). Computer simulations using Simul 5.0 were used to better understand the dynamics of analyte electromigration, as well as aiding de novo identification of unknown nutrients. There was excellent agreement between computer-simulated and experimental electropherograms for several classes of cationic metabolites as reflected by their relative migration times with an average error of <2.0%. Our studies revealed differential uptake of specific amino acids and nucleoside nutrients associated with distinct stages of bacterial growth. Herein, we demonstrate that CE can serve as an effective preconcentrator, desalter, and separator prior to ESI-MS, while providing additional qualitative information for unambiguous identification among isobaric and isomeric metabolites. The proposed strategy is particularly relevant for characterizing unknown yet biologically relevant metabolites that are not readily synthesized or commercially available.

Spectrum of FANCA mutations in Italian Fanconi anemia patients: identification of six novel alleles and phenotypic characterization of the S858R variant.

PubMed

Savino, Maria; Borriello, Adriana; D'Apolito, Maria; Criscuolo, Maria; Del Vecchio, Maria; Bianco, Anna Monica; Di Perna, Michele; Calzone, Rita; Nobili, Bruno; Zatterale, Adriana; Zelante, Leopoldo; Joenje, Hans; Della Ragione, Fulvio; Savoia, Anna

2003-10-01

Fanconi anemia (FA) is an autosomal recessive disorder characterized by genomic instability, bone marrow failure, congenital malformations, and cancer predisposition. FA is a genetically heterogeneous disease with at least seven genes so far identified. The role of FA proteins is unknown although they interact in a common functional pathway. Here, we report six novel FANCA sequence changes and review all the mutations identified in Italy. Except for two missense substitutions, all are expected to cause a premature termination of the FANCA protein at various sites throughout the molecule. The premature terminations are due to nonsense and splice site mutations, as well as small insertions and deletions, and large genomic rearrangements. The expected truncated proteins were not detectable on Western blot analyses. The FANCA-S858R variant is instead expressed at lower level than that seen in normal cell lines and is associated with a non-ubiquinated FANCD2 protein, strongly suggesting that the amino acid substitution is a disease-causing mutation. The spectrum of FA mutations is widely in agreement with the heterogeneous ethnic origin of the Italian population. Copyright 2003 Wiley-Liss, Inc.

Blood characterization using UV/vis spectroscopy

NASA Astrophysics Data System (ADS)

Mattley, Yvette D.; Mitrani-Gold, F.; Orton, S.; Bacon, Christina P.; Leparc, German F.; Bayona, M.; Potter, Robert L.; Garcia-Rubio, Luis H.

1995-05-01

The current methods used for typing blood involve an agglutination reaction which results from the association of specific antibodies with antigens present on the erythrocyte cell surface. While this method is effective, it requires involved laboratory procedures to detect the cell surface antigens. As an alternative technique, uv/vis spectroscopy has been investigated as a novel way to characterize and differentiate the blood types. Typing with this technique is based on spectral differences which appear throughout portions of both the ultraviolet and visible range. The origin of these spectral differences is unknown and presently under investigation. They may be due to intrinsic absorption differences at the molecular level, and/or they may be due to scattering differences brought about by either subtle variation in cell surface characteristics, cell shape or state of aggregation. As the background optical density in these samples is identified and accounted for, the spectral differences become more defined. This work and the continuation of this project will be included in a general database encompassing a wide range of blood samples. In addition, long term goals involve the investigation of diseased blood with the potential of providing a more rapid diagnosis for blood borne pathogens.

Best's vitelliform dystrophy (VMD2) maps between D11S903 and PYGM: No evidence for locus heterogeneity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weber, B.H.F.; Walker, D.; Mar, L.

1994-03-15

Vitelliform macular dystrophy, also known as Best's disease (BD), is an autosomal dominant disorder typically characterized by an accumulation of yellowish material in the macular area. The disease is slowly progressive and eventually results in atrophy of the retinal pigment epithelium and photoreceptor cells, thus severely impairing central vision. The biochemical defect underlying this condition is unknown. More recently, the BD locus (VMD2) was mapped to chromosome 11 by genetic analysis in three multigeneration Best's disease families using eight microsatellite markers spanning approximately 26 cM around the putative BD locus. The authors demonstrate linkage between Best's disease and the markersmore » used. Furthermore, haplotype analysis in unrelated Best's disease families identified three distinct haplotypes associated with the disease, strongly suggesting independent origins of the BD mutation. Finally, they characterized two recombinant BD chromosomes that significantly refine the location of the disease gene to a 3.7-cM interval between markers at D11S903 and PYGM. PCR-hybrid mapping sublocalized this interval to the pericentromeric region of chromosome 11. 47 refs., 4 figs., 1 tab.« less

Synaptic augmentation in a cortical circuit model reproduces serial dependence in visual working memory

PubMed Central

D’Esposito, Mark

2017-01-01

Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown. In the present study, we investigate the circuit-level origins of serial dependence in a biophysical model of cortex. We explore two distinct kinds of mechanisms: stable persistent activity during the memory delay period and dynamic “activity-silent” synaptic plasticity. We find that networks endowed with both strong reverberation to support persistent activity and dynamic synapses can closely reproduce behavioral serial dependence. Specifically, elevated activity drives synaptic augmentation, which biases activity on the subsequent trial, giving rise to a spatiotemporally tuned shift in the population response. Our hybrid neural model is a theoretical advance beyond abstract mathematical characterizations, offers testable hypotheses for physiological research, and demonstrates the power of biological insights to provide a quantitative explanation of human behavior. PMID:29244810

Improved Dosimetric and Clinical Outcomes With Intensity-Modulated Radiotherapy for Head-and-Neck Cancer of Unknown Primary Origin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.ed; Li Baoqing; Farwell, D. Gregory

2011-03-01

Purpose: To compare differences in dosimetric, clinical, and quality-of-life endpoints among a cohort of patients treated by intensity-modulated radiotherapy (IMRT) and conventional radiotherapy (CRT) for head-and-neck cancer of unknown primary origin. Methods and Materials: The medical records of 51 patients treated by radiation therapy for squamous cell carcinoma of the head and neck presenting as cervical lymph node metastasis of occult primary origin were reviewed. Twenty-four patients (47%) were treated using CRT, and 27 (53%) were treated using IMRT. The proportions of patients receiving concurrent chemotherapy were 54% and 63%, respectively. Results: The 2-year estimates of overall survival, local-regional control,more » and disease-specific survival for the entire patient population were 86%, 89%, and84%, respectively. There were no significant differences in any of these endpoints with respect to radiation therapy technique (p > 0.05 for all). Dosimetric analysis revealed that the use of IMRT resulted in significant improvements with respect to mean dose and V30 to the contralateral (spared) parotid gland. In addition, mean doses to the ipsilateral inner and middle ear structures were significantly reduced with IMRT (p < 0.05 for all). The incidence of severe xerostomia in the late setting was 58% and 11% among patients treated by CRT and IMRT, respectively (p < 0.001). The percentages of patients who were G-tube dependent at 6 months after treatment were 42% and 11%, respectively (p < 0.001). Conclusions: IMRT results in significant improvements in the therapeutic ratio among patients treated by radiation therapy for head-and-neck cancer of unknown primary origin.« less

Radiation Therapy in the Management of Head-and-Neck Cancer of Unknown Primary Origin: How Does the Addition of Concurrent Chemotherapy Affect the Therapeutic Ratio?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Allen M., E-mail: allen.chen@ucdmc.ucdavis.edu; Farwell, D. Gregory; Lau, Derick H.

2011-10-01

Purpose: To determine how the addition of cisplatin-based concurrent chemotherapy to radiation therapy influences outcomes among a cohort of patients treated for head-and-neck cancer of unknown primary origin. Methods and Materials: The medical records of 60 consecutive patients treated by radiation therapy for squamous cell carcinoma of the head and neck presenting as cervical lymph node metastasis of occult primary origin were reviewed. Thirty-two patients (53%) were treated by concurrent chemoradiation, and 28 patients (47%) were treated by radiation therapy alone. Forty-five patients (75%) received radiation therapy after surgical resection, and 15 patients (25%) received primary radiation therapy. Thirty-five patientsmore » (58%) were treated by intensity-modulated radiotherapy. Results: The 2-year estimates of overall survival, local-regional control, and progression-free survival were 89%, 89%, and 79%, respectively, among patients treated by chemoradiation, compared to 90%, 92%, and 83%, respectively, among patients treated by radiation therapy alone (p > 0.05, for all). Exploratory analysis failed to identify any subset of patients who benefited from the addition of concurrent chemotherapy to radiation therapy. The use of concurrent chemotherapy was associated with a significantly increased incidence of Grade 3+ acute and late toxicity (p < 0.001, for both). Conclusions: Concurrent chemoradiation is associated with significant toxicity without a clear advantage to overall survival, local-regional control, and progression-free survival in the treatment of head-and-neck cancer of unknown primary origin. Although selection bias cannot be ignored, prospective data are needed to further address this question.« less

Engagement of Patients With Advanced Cancer

ClinicalTrials.gov

2017-05-12

End of Life; Advanced Cancer; Lung Neoplasm; Gastric Cancer; Colon Cancer; Glioblastoma Multiforme; Head and Neck Neoplasms; Rectum Cancer; Melanoma; Kidney Cancer; Prostate Cancer; Testicular Neoplasms; Liver Cancer; Cancer of Unknown Origin

1. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1938, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, George J. Vaillancourt, Photographer, 1938, from a film by unknown, VIEW OF ORIGINAL ROOF TRUSSES. - Market House, Market Square, Providence, Providence County, RI

14. Photographic copy of photograph dated ca. 1925; Photographer unknown; ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photographic copy of photograph dated ca. 1925; Photographer unknown; Original in Rath collection at Iowa State University Libraries, Department of Special Collection, Ames, Iowa; Filed under: Rath Packing Company, Public Relations, Symbol N, Box 106, File 6: THE RATH COMPLEX IN THE MID 1920; LARGE BUILDING TO LEFT OF SMOKESTACK IS HOG KILL (BUILDING 40); LOOKING NORTH FROM ACROSS CEDAR RIVER - Rath Packing Company, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Characterizing unknown systematics in large scale structure surveys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, Nishant; Ho, Shirley; Myers, Adam D.

Photometric large scale structure (LSS) surveys probe the largest volumes in the Universe, but are inevitably limited by systematic uncertainties. Imperfect photometric calibration leads to biases in our measurements of the density fields of LSS tracers such as galaxies and quasars, and as a result in cosmological parameter estimation. Earlier studies have proposed using cross-correlations between different redshift slices or cross-correlations between different surveys to reduce the effects of such systematics. In this paper we develop a method to characterize unknown systematics. We demonstrate that while we do not have sufficient information to correct for unknown systematics in the data,more » we can obtain an estimate of their magnitude. We define a parameter to estimate contamination from unknown systematics using cross-correlations between different redshift slices and propose discarding bins in the angular power spectrum that lie outside a certain contamination tolerance level. We show that this method improves estimates of the bias using simulated data and further apply it to photometric luminous red galaxies in the Sloan Digital Sky Survey as a case study.« less

Near real-time measurement of forces applied by an optical trap to a rigid cylindrical object

NASA Astrophysics Data System (ADS)

Glaser, Joseph; Hoeprich, David; Resnick, Andrew

2014-07-01

An automated data acquisition and processing system is established to measure the force applied by an optical trap to an object of unknown composition in real time. Optical traps have been in use for the past 40 years to manipulate microscopic particles, but the magnitude of applied force is often unknown and requires extensive instrument characterization. Measuring or calculating the force applied by an optical trap to nonspherical particles presents additional difficulties which are also overcome with our system. Extensive experiments and measurements using well-characterized objects were performed to verify the system performance.

14. Photocopy of photograph (original photograph in possession of 30th ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph (original photograph in possession of 30th Audiovisual Squadron, Vandenberg Air Force Base, California). Photography by United States Air Force, date unknown. ATLAS VEHICLE BEING PREPARED FOR LAUNCH FROM SLC-3E. NOTE EXTERNAL SHEATHING AND CUPOLA ON MOBILE SERVICE TOWER. - Vandenberg Air Force Base, Space Launch Complex 3, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

40. Photocopy of photograph (negative made from original photograph on ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Photocopy of photograph (negative made from original photograph on file at Veterans Administration in Wichita, Kansas), photographer unknown, ca. 1933. Panoramic aerial view of Veterans Administration Center, view north, City of Wichita in background, Building 8 is first structure on right - Veterans Administration Center, Officers Duplex Quarters, 5302 East Kellogg (Legal Address); 5500 East Kellogg (Common Address), Wichita, Sedgwick County, KS

3. Photo copy of photograph, (original in Forest Service Office, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photo copy of photograph, (original in Forest Service Office, Elkins, WV, photo #292222), photographer unknown, ca. 1935. VIEW EAST, CCC CAMP PARSONS, FOREST SERVICE TRUCK STORAGE ON LEFT, WATER TANK (DEMOLISHED), MESS HALL (DEMOLISHED). (see also historic photograph WV-237-20, WV-237-35) - Parsons Nursery, Civilian Conservation Corps Garage, South side of U.S. Route 219, Parsons, Tucker County, WV

Understanding the 2013 H7N9 avian influenza outbreak in poultry: field epidemiology and experimental pathogenesis studies

USDA-ARS?s Scientific Manuscript database

The influenza A (H7N9) virus is of avian origin and is responsible for infections in human in large urban areas of China in spring 2013. The original source of the virus from poultry farms is unknown but the live poultry market (LPM) system has served as an amplifier of the virus, especially in whol...

2. Photocopy of photograph (original print located in Pope & ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Photocopy of photograph (original print located in Pope & Talbot Archives Port Gamble, WA). Unknown Photographer, Circa 1953. View of Port Gamble and surroundings, aerial shot facing west. Port Gamble Bay, townsite and millsite in foreground, Hood Canal and Olympic Mountains in the background. - Port Gamble National Historic Landmark, Bounded by Hood Canal, Port Gamble Bay, State Road 104, & Town Limits, Port Gamble, Kitsap County, WA

3. Photographic copy of a photograph, dated June 1993 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Photographic copy of a photograph, dated June 1993 (original print in the possession of CSSD-HO, Huntsville, AL). Gerald Greenwood, photographer. Interior of remote launch operations building, room unknown, demonstrating the result of salvaging operations. Note the ceiling tiles have been removed - Stanley R. Mickelsen Safeguard Complex, Remote Launch Operations Building, Near Service Road exit from Patrol Road, Nekoma, Cavalier County, ND

53. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

53. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1960. View of Whitney Water Filtration Plant Laboratory. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

50. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1959. The sand washer designed by New Haven Water Company. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

29. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative VIEW OF THE DOWNSTREAM SIDE OF DAM No.4, TAKEN FROM BELOW; THE COVERED FOOTBRIDGE. THE BUILDING IN THE BACKGROUND HAS SINCE BEEN DEMOLISHED. - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

49. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

49. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1935. Sand cleaning at the Whitney Filtration Plant. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

16. Photographic copy of photograph (from original 4 x 5 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken prior to June 1942 by unknown photographer. SOUTHWEST BIRDS-EYE VIEW OF WAREHOUSES (BLDGS. 802-805). - Oakland Army Base, Warehouse Type, Tobruk Street, between Warehouse Road & Fifteenth Street, Oakland, Alameda County, CA

1. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopy of a photograph (original print in the collection of the Claremont Historical Society) photographer unknown, no date ALBERT BALL, MECHANICAL ENGINEER FOR THE SULLIVAN MACHINERY COMPANY, WITH AN EARLY DIAMOND CHANNELER. BALL HELD OVER 130 PATENTS ON MINING EQUIPMENT WHICH INCREASED MINE PRODUCTION AND REVOLUTIONIZED THE PRODUCTION OF COAL FUEL. - Sullivan Machinery Company, Main Street between Pearl & Water Streets, Claremont, Sullivan County, NH

Adaptive Neural Output Feedback Control for Nonstrict-Feedback Stochastic Nonlinear Systems With Unknown Backlash-Like Hysteresis and Unknown Control Directions.

PubMed

Yu, Zhaoxu; Li, Shugang; Yu, Zhaosheng; Li, Fangfei

2018-04-01

This paper investigates the problem of output feedback adaptive stabilization for a class of nonstrict-feedback stochastic nonlinear systems with both unknown backlashlike hysteresis and unknown control directions. A new linear state transformation is applied to the original system, and then, control design for the new system becomes feasible. By combining the neural network's (NN's) parameterization, variable separation technique, and Nussbaum gain function method, an input-driven observer-based adaptive NN control scheme, which involves only one parameter to be updated, is developed for such systems. All closed-loop signals are bounded in probability and the error signals remain semiglobally bounded in the fourth moment (or mean square). Finally, the effectiveness and the applicability of the proposed control design are verified by two simulation examples.

Sliding Mode Observer-Based Current Sensor Fault Reconstruction and Unknown Load Disturbance Estimation for PMSM Driven System

PubMed Central

Li, Xiangfei; Lin, Yuliang

2017-01-01

This paper proposes a new scheme of reconstructing current sensor faults and estimating unknown load disturbance for a permanent magnet synchronous motor (PMSM)-driven system. First, the original PMSM system is transformed into two subsystems; the first subsystem has unknown system load disturbances, which are unrelated to sensor faults, and the second subsystem has sensor faults, but is free from unknown load disturbances. Introducing a new state variable, the augmented subsystem that has sensor faults can be transformed into having actuator faults. Second, two sliding mode observers (SMOs) are designed: the unknown load disturbance is estimated by the first SMO in the subsystem, which has unknown load disturbance, and the sensor faults can be reconstructed using the second SMO in the augmented subsystem, which has sensor faults. The gains of the proposed SMOs and their stability analysis are developed via the solution of linear matrix inequality (LMI). Finally, the effectiveness of the proposed scheme was verified by simulations and experiments. The results demonstrate that the proposed scheme can reconstruct current sensor faults and estimate unknown load disturbance for the PMSM-driven system. PMID:29211017

c-mip impairs podocyte proximal signaling and induces heavy proteinuria

PubMed Central

Zhang, Shao-Yu; Kamal, Maud; Dahan, Karine; Pawlak, André; Ory, Virginie; Desvaux, Dominique; Audard, Vincent; Candelier, Marina; Mohamed, Fatima Ben; Matignon, Marie; Christov, Christo; Decrouy, Xavier; Bernard, Veronique; Mangiapan, Gilles; Lang, Philippe; Guellaën, Georges; Ronco, Pierre; Sahali, Djillali

2010-01-01

Idiopathic nephrotic syndrome comprises several podocyte diseases of unknown origin, affecting the glomerular podocyte, which plays a key role in controlling the permeability of the kidney filter to proteins. It is characterized by the daily loss of more than 3 g of protein in urine, with no inflammatory lesions or cell infiltration. Nephrotic syndrome may be associated with serious complications, including sodium retention, hyperlipidemia, infectious diseases and thromboembolic events. The molecular mechanisms underlying non genetic nephrotic syndromes are unknown. We report here that the abundance of c-mip (c-maf inducing protein) increases in the podocytes of patients with acquired idiopathic nephrotic syndromes, including minimal change nephrotic syndrome (MCNS), a subset of focal and segmental glomerulosclerosis (FSGS) and membranous nephropathy (MN), in which the podocyte is the main target of injury. Transgenic mice overproducing c-mip in podocytes developed proteinuria without morphological alterations, inflammatory lesions or cell infiltration. We found that c-mip turned off podocyte signaling by preventing the interaction of nephrin with the tyrosine kinase Fyn, thereby decreasing nephrin phosphorylation in vitro and in vivo. Moreover, c-mip inhibited interactions between Fyn and N-WASP and between Nck and nephrin, potentially accounting for cytoskeletal disorganization and the effacement of foot processes. The intravenous injection of a small interfering RNA (siRNA) targeting c-mip prevented lipopolysaccharide-induced proteinuria in mice. These results provide new insights into the molecular mechanism of acquired podocyte diseases. PMID:20484117

Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles.

PubMed

Andreasen, Simon; Tan, Qihua; Agander, Tina Klitmøller; Steiner, Petr; Bjørndal, Kristine; Høgdall, Estrid; Larsen, Stine Rosenkilde; Erentaite, Daiva; Olsen, Caroline Holkmann; Ulhøi, Benedicte Parm; von Holstein, Sarah Linéa; Wessel, Irene; Heegaard, Steffen; Homøe, Preben

2018-02-21

Adenoid cystic carcinoma is among the most frequent malignancies in the salivary and lacrimal glands and has a grave prognosis characterized by frequent local recurrences, distant metastases, and tumor-related mortality. Conversely, adenoid cystic carcinoma of the breast is a rare type of triple-negative (estrogen and progesterone receptor, HER2) and basal-like carcinoma, which in contrast to other triple-negative and basal-like breast carcinomas has a very favorable prognosis. Irrespective of site, adenoid cystic carcinoma is characterized by gene fusions involving MYB, MYBL1, and NFIB, and the reason for the different clinical outcomes is unknown. In order to identify the molecular mechanisms underlying the discrepancy in clinical outcome, we characterized the phenotypic profiles, pattern of gene rearrangements, and global microRNA expression profiles of 64 salivary gland, 9 lacrimal gland, and 11 breast adenoid cystic carcinomas. All breast and lacrimal gland adenoid cystic carcinomas had triple-negative and basal-like phenotypes, while salivary gland tumors were indeterminate in 13% of cases. Aberrations in MYB and/or NFIB were found in the majority of cases in all three locations, whereas MYBL1 involvement was restricted to tumors in the salivary gland. Global microRNA expression profiling separated salivary and lacrimal gland adenoid cystic carcinoma from their respective normal glands but could not distinguish normal breast adenoid cystic carcinoma from normal breast tissue. Hierarchical clustering separated adenoid cystic carcinomas of salivary gland origin from those of the breast and placed lacrimal gland carcinomas in between these. Functional annotation of the microRNAs differentially expressed between salivary gland and breast adenoid cystic carcinoma showed these as regulating genes involved in metabolism, signal transduction, and genes involved in other cancers. In conclusion, microRNA dysregulation is the first class of molecules separating adenoid cystic carcinoma according to the site of origin. This highlights a novel venue for exploring the biology of adenoid cystic carcinoma.

Deterministic Assisted Clone of an Arbitrary Two- and Three-qubit States via Multi-qubit Brown State

NASA Astrophysics Data System (ADS)

Hou, Kui; Zhu, Cheng-Jie; Yang, Ya-Ping

2017-08-01

We present two schemes for deterministic assisted clone(DAC) of an unknown two- and three-qubit entangled states with assistance via muti-qubit Brown state. In the schemes, the sender wish to teleport an unknown original entangled state which from the state preparer, and then create a perfect copy of the unknown state at her place. The DAC schemes include two stages. The first stage requires teleportation with Bell-state measurements via a five-qubit Brown state(or seven-qubit Brown state) as the quantum channel. In the second stage, to help the sender realize the quantum cloning, the state preparer performs projective measurements on their own particles which from the sender, then the sender can acquire a perfect copy of the unknown state by means of some appropriate unitary operations. Furthermore, the total success probability for assisted cloning a perfect copy of the unknown state can reach 1 in our schemes.

Implementation of an improved adaptive-implicit method in a thermal compositional simulator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, T.B.

1988-11-01

A multicomponent thermal simulator with an adaptive-implicit-method (AIM) formulation/inexact-adaptive-Newton (IAN) method is presented. The final coefficient matrix retains the original banded structure so that conventional iterative methods can be used. Various methods for selection of the eliminated unknowns are tested. AIM/IAN method has a lower work count per Newtonian iteration than fully implicit methods, but a wrong choice of unknowns will result in excessive Newtonian iterations. For the problems tested, the residual-error method described in the paper for selecting implicit unknowns, together with the IAN method, had an improvement of up to 28% of the CPU time over the fullymore » implicit method.« less

Parameter identification of thermophilic anaerobic degradation of valerate.

PubMed

Flotats, Xavier; Ahring, Birgitte K; Angelidaki, Irini

2003-01-01

The considered mathematical model of the decomposition of valerate presents three unknown kinetic parameters, two unknown stoichiometric coefficients, and three unknown initial concentrations for biomass. Applying a structural identifiability study, we concluded that it is necessary to perform simultaneous batch experiments with different initial conditions for estimating these parameters. Four simultaneous batch experiments were conducted at 55 degrees C, characterized by four different initial acetate concentrations. Product inhibition of valerate degradation by acetate was considered. Practical identification was done optimizing the sum of the multiple determination coefficients for all measured state variables and for all experiments simultaneously. The estimated values of kinetic parameters and stoichiometric coefficients were characterized by the parameter correlation matrix, the confidence interval, and the student's t-test at 5% significance level with positive results except for the saturation constant, for which more experiments for improving its identifiability should be conducted. In this article, we discuss kinetic parameter estimation methods.

Proteins of Unknown Biochemical Function: A Persistent Problem and a Roadmap to Help Overcome It.

PubMed

Niehaus, Thomas D; Thamm, Antje M K; de Crécy-Lagard, Valérie; Hanson, Andrew D

2015-11-01

The number of sequenced genomes is rapidly increasing, but functional annotation of the genes in these genomes lags far behind. Even in Arabidopsis (Arabidopsis thaliana), only approximately 40% of enzyme- and transporter-encoding genes have credible functional annotations, and this number is even lower in nonmodel plants. Functional characterization of unknown genes is a challenge, but various databases (e.g. for protein localization and coexpression) can be mined to provide clues. If homologous microbial genes exist-and about one-half the genes encoding unknown enzymes and transporters in Arabidopsis have microbial homologs-cross-kingdom comparative genomics can powerfully complement plant-based data. Multiple lines of evidence can strengthen predictions and warrant experimental characterization. In some cases, relatively quick tests in genetically tractable microbes can determine whether a prediction merits biochemical validation, which is costly and demands specialized skills. © 2015 American Society of Plant Biologists. All Rights Reserved.

Development of a GC/Quadrupole-Orbitrap Mass Spectrometer, Part I: Design and Characterization

PubMed Central

2015-01-01

Identification of unknown compounds is of critical importance in GC/MS applications (metabolomics, environmental toxin identification, sports doping, petroleomics, and biofuel analysis, among many others) and remains a technological challenge. Derivation of elemental composition is the first step to determining the identity of an unknown compound by MS, for which high accuracy mass and isotopomer distribution measurements are critical. Here, we report on the development of a dedicated, applications-grade GC/MS employing an Orbitrap mass analyzer, the GC/Quadrupole-Orbitrap. Built from the basis of the benchtop Orbitrap LC/MS, the GC/Quadrupole-Orbitrap maintains the performance characteristics of the Orbitrap, enables quadrupole-based isolation for sensitive analyte detection, and includes numerous analysis modalities to facilitate structural elucidation. We detail the design and construction of the instrument, discuss its key figures-of-merit, and demonstrate its performance for the characterization of unknown compounds and environmental toxins. PMID:25208235

7. Photocopy of photograph (original print in possession of Mary ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph (original print in possession of Mary Lane Knott, 508 Central Avenue, Ridgely MD 21660). Photographer and date unknown, Circa 1900. VIEW EAST, SOUTHWEST FRONT, NORTHWEST SIDE Front and side elevations. Note the duplication of the recessed store front with display windows. Note the break in the original clapboard siding toward the rear on the Northwest side and the new clapboard siding near the buggy. Near the buggy wheel an original brick pier. Note the panelling below the display windows and the penny gumball machine on the wall marked 'Adams Tutti-Frutti'. - 510 Central Avenue (Commercial Building), Ridgely, Caroline County, MD

Constraints on Early Mars Evolution and Dichotomy Origin from Relaxation Modeling of Dichotomy Boundary in the Ismenius Region

NASA Technical Reports Server (NTRS)

Guest, A.; Smrekar, S. E.

2004-01-01

The Martian dichotomy is a global feature separating the northern and southern hemispheres. The 3.5 - 4 Gyr old feature is manifested by a topographic difference of 2-6 km and crustal thickness difference of approx. 15 - 30 km between the two hemispheres. In the Ismenius region, sections of the boundary are characterized by a single scarp with a slope of approx. 20 deg. - 23 deg. and are believed to be among the most well preserved parts of the dichotomy boundary. The origin of the dichotomy is unknown. Endogenic hypotheses do not predict the steep slopes (scarps) of the dichotomy boundary. Exogenic models for forming the northern lowlands by impact cratering, associate the scarps along the dichotomy boundary with craters' rims, but are not globally consistent with the topography and gravity. In order to better understand the origin of the Martian dichotomy, it is necessary to know if the steep scarps along the boundary represent the original shape of the dichotomy. Smrekar et al. presented evidence showing that the boundary scarp in Ismenius is a fault along which the highland crust was down faulted. We test whether the relaxation process could produce faulting along the dichotomy boundary and examine the crustal and mantle conditions that would allow for faulting to occur within 1 Gyr and preserve the long wavelength topography over another 3 Gyr. We approach the problem by a combination of numerical and semi-analytical modeling. We test different viscosity profiles and crustal thicknesses by comparing our modeled magnitude, location and timing of plastic strain and displacements to detailed geologic observations in the Ismenius region.

Antimicrobial Resistance Profiles of Listeria monocytogenes and Listeria innocua Isolated from Ready-to-Eat Products of Animal Origin in Spain.

PubMed

Escolar, Cristina; Gómez, Diego; Del Carmen Rota García, María; Conchello, Pilar; Herrera, Antonio

2017-06-01

The objective of this work was to investigate the antimicrobial resistance in Listeria spp. isolated from food of animal origin. A total of 50 Listeria strains isolated from meat and dairy products, consisting of 7 Listeria monocytogenes and 43 Listeria innocua strains, were characterized for antimicrobial susceptibility against nine antimicrobials. The strains were screened by real-time PCR for the presence of antimicrobial resistance genes: tet M, tet L, mef A, msr A, erm A, erm B, lnu A, and lnu B. Multidrug resistance was identified in 27 Listeria strains, 4 belonging to L. monocytogenes. Resistance to clindamycin was the most common resistance phenotype and was identified in 45 Listeria strains; the mechanisms of resistance are still unknown. A medium prevalence of resistance to tetracycline (15 and 9 resistant and intermediate strains) and ciprofloxacin (13 resistant strains) was also found. Tet M was detected in Listeria strains with reduced susceptibility to tetracycline, providing evidence that both L. innocua and L. monocytogenes displayed acquired resistance. The presence of antimicrobial resistance genes in L. innocua and L. monocytogenes indicates that these genes may be transferred to commensal and pathogenic bacteria via the food chain; besides this, antibiotic resistance in L. monocytogenes could compromise the effective treatment of listeriosis in humans.

Molecular Characterization of Organosulfur Compounds in Biodiesel and Diesel Fuel Secondary Organic Aerosol

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blair, Sandra L.; MacMillan, Amanda C.; Drozd, Greg T.

Secondary organic aerosol (SOA), formed in a process of photooxidization of diesel fuel, biodiesel fuel, and 20% biodiesel fuel/80% diesel fuel mixture, are prepared under high-NOx conditions in the presence and absence of sulfur dioxide (SO2), ammonia (NH3), and relative humidity (RH). The composition of condensed-phase organic compounds in SOA is measured using several analytical techniques including aerosol mass spectrometry (AMS), high-resolution nanospray desorption electrospray ionization mass spectrometry (nano-DESI/HRMS), and ultra high resolution and mass accuracy 21T Fourier transform ion cyclotron resonance mass spectrometry (21T FT-ICR MS). Results demonstrate that sulfuric acid and condensed organosulfur species formed in photooxidation experimentsmore » with SO2 are present in the SOA particles. Fewer organosulfur species are formed in the high humidity experiments, performed at RH 90%, in comparison with experiments done under dry conditions. There is a strong overlap of organosulfur species observed in this study with previous field and chamber studies of SOA. Many mass spectrometry peaks of organosulfates (R–OS(O)2OH) in field studies previously designated as biogenic or of unknown origin might have originated from anthropogenic sources, such as photooxidation of hydrocarbons present in diesel and biodiesel fuel.« less

Human (Clovis)-gomphothere (Cuvieronius sp.) association ∼ 13,390 calibrated yBP in Sonora, Mexico.

PubMed

Sanchez, Guadalupe; Holliday, Vance T; Gaines, Edmund P; Arroyo-Cabrales, Joaquín; Martínez-Tagüeña, Natalia; Kowler, Andrew; Lange, Todd; Hodgins, Gregory W L; Mentzer, Susan M; Sanchez-Morales, Ismael

2014-07-29

The earliest known foragers to populate most of North America south of the glaciers [∼ 11,500 to ≥ ∼ 10,800 (14)C yBP; ∼ 13,300 to ∼ 12,800 calibrated (Cal) years] made distinctive "Clovis" artifacts. They are stereotypically characterized as hunters of Pleistocene megamammals (mostly mammoth) who entered the continent via Beringia and an ice-free corridor in Canada. The origins of Clovis technology are unclear, however, with no obvious evidence of a predecessor to the north. Here we present evidence for Clovis hunting and habitation ∼ 11,550 yBP (∼ 13,390 Cal years) at "El Fin del Mundo," an archaeological site in Sonora, northwestern Mexico. The site also includes the first evidence to our knowledge for gomphothere (Cuvieronius sp.) as Clovis prey, otherwise unknown in the North American archaeological record and terminal Pleistocene paleontological record. These data (i) broaden the age and geographic range for Clovis, establishing El Fin del Mundo as one of the oldest and southernmost in situ Clovis sites, supporting the hypothesis that Clovis had its origins well south of the gateways into the continent, and (ii) expand the make-up of the North American megafauna community just before extinction.

Human (Clovis)-gomphothere (Cuvieronius sp.) association ∼13,390 calibrated yBP in Sonora, Mexico

NASA Astrophysics Data System (ADS)

Sanchez, Guadalupe; Holliday, Vance T.; Gaines, Edmund P.; Arroyo-Cabrales, Joaquín; Martínez-Tagüeña, Natalia; Kowler, Andrew; Lange, Todd; Hodgins, Gregory W. L.; Mentzer, Susan M.; Sanchez-Morales, Ismael

2014-07-01

The earliest known foragers to populate most of North America south of the glaciers [∼11,500 to ≥ ∼10,800 14C yBP; ∼13,300 to ∼12,800 calibrated (Cal) years] made distinctive "Clovis" artifacts. They are stereotypically characterized as hunters of Pleistocene megamammals (mostly mammoth) who entered the continent via Beringia and an ice-free corridor in Canada. The origins of Clovis technology are unclear, however, with no obvious evidence of a predecessor to the north. Here we present evidence for Clovis hunting and habitation ∼11,550 yBP (∼13,390 Cal years) at "El Fin del Mundo," an archaeological site in Sonora, northwestern Mexico. The site also includes the first evidence to our knowledge for gomphothere (Cuvieronius sp.) as Clovis prey, otherwise unknown in the North American archaeological record and terminal Pleistocene paleontological record. These data (i) broaden the age and geographic range for Clovis, establishing El Fin del Mundo as one of the oldest and southernmost in situ Clovis sites, supporting the hypothesis that Clovis had its origins well south of the gateways into the continent, and (ii) expand the make-up of the North American megafauna community just before extinction.

Human (Clovis)–gomphothere (Cuvieronius sp.) association ∼13,390 calibrated yBP in Sonora, Mexico

PubMed Central

Sanchez, Guadalupe; Holliday, Vance T.; Gaines, Edmund P.; Arroyo-Cabrales, Joaquín; Martínez-Tagüeña, Natalia; Kowler, Andrew; Lange, Todd; Hodgins, Gregory W. L.; Mentzer, Susan M.; Sanchez-Morales, Ismael

2014-01-01

The earliest known foragers to populate most of North America south of the glaciers [∼11,500 to ≥ ∼10,800 14C yBP; ∼13,300 to ∼12,800 calibrated (Cal) years] made distinctive “Clovis” artifacts. They are stereotypically characterized as hunters of Pleistocene megamammals (mostly mammoth) who entered the continent via Beringia and an ice-free corridor in Canada. The origins of Clovis technology are unclear, however, with no obvious evidence of a predecessor to the north. Here we present evidence for Clovis hunting and habitation ∼11,550 yBP (∼13,390 Cal years) at “El Fin del Mundo,” an archaeological site in Sonora, northwestern Mexico. The site also includes the first evidence to our knowledge for gomphothere (Cuvieronius sp.) as Clovis prey, otherwise unknown in the North American archaeological record and terminal Pleistocene paleontological record. These data (i) broaden the age and geographic range for Clovis, establishing El Fin del Mundo as one of the oldest and southernmost in situ Clovis sites, supporting the hypothesis that Clovis had its origins well south of the gateways into the continent, and (ii) expand the make-up of the North American megafauna community just before extinction. PMID:25024193

Genotypic Characterization of Rickettsia bellii Reveals Distinct Lineages in the United States and South America.

PubMed

Krawczak, Felipe S; Labruna, Marcelo B; Hecht, Joy A; Paddock, Christopher D; Karpathy, Sandor E

2018-01-01

The bacterium Rickettsia bellii belongs to a basal group of rickettsiae that diverged prior to the pathogenic spotted fever group and typhus group Rickettsia species. Despite a diverse representation of R. bellii across more than 25 species of hard and soft ticks in the American continent, phylogeographical relationships among strains of this basal group- Rickettsia species are unknown; the work described here explores these relationships. DNA was extracted from 30 R. bellii tick isolates: 15 from the United States, 14 from Brazil, and 1 from Argentina. A total of 2,269 aligned nucleotide sites of 3 protein coding genes ( glt A, atp A, and cox A) and 2 intergenic regions ( rpm E -tRN A fmet and RC1027-xth A 2 ) were concatenated and subjected to phylogenetic analysis by Bayesian methods. Results showed a separation of almost all isolates between North and South Americas, suggesting that they have radiated within their respective continents. Phylogenetic positions of the 30 isolates could be a result of not only their geographical origin but also the tick hosts they have coevolved with. Whether R. bellii originated with ticks in North or South America remains obscure, as our analyses did not show evidence for greater genetic divergence of R. bellii in either continent.

48. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

48. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1935. Loading dirty sand into an ejector for transport to the sand washer. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

Psychological Study on the Origin of Life, Death and Life after Death: Differences between Beliefs According to Age and Schooling

ERIC Educational Resources Information Center

Silva Bautista, Jesús; Herrera Escobar, Venazir; Corona Miranda, Rodolfo

2018-01-01

The present work proposes a psychological study via beliefs, about the origin of life, death, and life after death. Beliefs have played a decisive role in the development of humanity, from the primitive man who gave to the unknown divine forces, the judgments of the Holy Inquisition in the Medieval Age, the impact provoked by the conviction that…

42. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer and date unknown. Mixing concrete for the construction of the slow sand filter circa 1903. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

44. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

44. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1904. View of bricklayers erecting exterior walls on the slow sand filter. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

47. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

47. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer and date unknown. View of main gallery between filter beds at Whitney Filtration Plant. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

43. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer and date unknown. View of forms used to create walls for the slow sand filter. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

17. Photocopy of photograph (original copy in Edison collection). Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of photograph (original copy in Edison collection). Photographer and date unknown, although probably taken before 1920. VIEW OF NORTH END OF TULE RIVER POWERHOUSE SHOWING POWERHOUSE AT PHOTO CENTER, TRANSFORMER BUILDING TO RIGHT OF POWERHOUSE, GARAGE TO LEFT OF POWERHOUSE, AND OPERATOR COTTAGE BEHIND POWERHOUSE AND TRANSFORMER HOUSE. VIEW TO SOUTHEAST. - Tule River Hydroelectric Project, Water Conveyance System, Middle Fork Tule River, Springville, Tulare County, CA

15. Photocopy of photograph (Original print, Wallie V. Funk Collection.) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of photograph (Original print, Wallie V. Funk Collection.) Photographer unknown. Published in the Anacortes American, 12 October 1911; 'Plant of the Anacortes Ice Company and Curtis Dock.' Photograph probably earlier. View looking northwest, left to right; Cement and Plaster Warehouse; Ice Plant (with towers); Cold Storage Warehouse; Freight Warehouse; a warehouse; and early ticket office. - Curtis Wharf, O & Second Streets, Anacortes, Skagit County, WA

51. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

51. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1960. Dr. Samuel Jacobson examining samples of water cultured on agar material. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

45. Photographic copy of photograph, dated October 1970 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Photographic copy of photograph, dated October 1970 (original print in possession of CSSD-HO, Huntsville, AL). Photographer unknown. Aerial mid-construction view (northeast to southwest) of perimeter acquisition radar building and par power plant. These buildings were approximately 33% complete at the time - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

The origin of recently established red fox populations in the United States: translocations or natural range expansions?

Treesearch

Mark J. Statham; Benjamin N. Sacks; Keith B. Aubry; John D. Perrine; Samantha M. Wisely

2012-01-01

Red foxes (Vulpes vulpes) are native to boreal and western montane portions of North America but their origins are unknown in many lowland areas of the United States. Red foxes were historically absent from much of the East Coast at the time of European settlement and did not become common until the mid-1800s. Some early naturalists described an...

30. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1934, photographer unknown 3 1/4 X 4 5/8 inch negative INTAKE TO THE POWER CANAL AT DAM No. 5. IDE'S 'ROUND BUILDING' IN THE FREEMAN AND O'NEIL COMPLEX IS VISIBLE ON THE LEFT. - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

23. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

23. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative BUILDING OF DAM No. 3, LOOKING EASTWARDS FROM THE NORTH BANK. CONSTRUCTION OF THE WOODEN FORMWORK USED IN CONSTRUCTING THE DAM IS VISIBLE IN THE FOREGROUND - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

46. Photographic copy of photograph, dated 21 August 1972 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. Photographic copy of photograph, dated 21 August 1972 (original print in possession of CSSD-HO, Huntsville, AL). Photographer unknown. View from below of the sloping perimeter acquisition radar building face or "radar eye", emphasizing a portion of the over 6,800 radar penetrations - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND

52. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1960. The Whitney Filtration Plant Laboratory with Dr. Samuel Jacobson at work. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

6. Photographic copy of photograph (from original 4 x 5 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken April 6, 1942 by unknown photographer. SOUTH AND EAST SIDES OBLIQUE VIEW OF PRIVATE VEHICLE INSPECTION BUILDING (VEHICLE SHED, BLDG. 4). - Oakland Army Base, Private Vehicle Inspection Building, Africa Street & Bataan Avenue, Oakland, Alameda County, CA

11. Photographic copy of photograph (from original 4 x 5 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photographic copy of photograph (from original 4 x 5 black and white print in the Army Port Contractors' 'Completion Report' at the Engineering Office, Oakland Army Base, California). Photograph taken January 31, 1942 by unknown photographer. EAST AND NORTH SIDES OBLIQUE VIEW OF EXCHANGE CAFETERIA (BLDG. 60). - Oakland Army Base, Private Exchange Cafeteria, Bataan Avenue & Attu Street, facing Post Headquarters Building, Oakland, Alameda County, CA

Genomic Testing and Resulting Medical Decisions

ClinicalTrials.gov

2017-10-03

Cancer of Unknown Origin; Cancer Refractory; Cancer of Stomach; Cancer Head Neck; Cancer of Skin; Cancer, Lung; Cancer Colorectal; Cancer of Esophagus; Cancer, Bladder; Cancer, Uterus; Cancer Cervix; Cancer Liver; Cancer, Kidney; Cancer, Breast; Hematologic Neoplasms

Optimal Treatment Decision for Brain Metastases of Unknown Primary Origin: The Role and Timing of Radiosurgery

PubMed Central

Han, Hyun Jin; Chang, Won Seok; Jung, Hyun Ho; Park, Yong Gou

2016-01-01

Background Up to 15% of all patients with brain metastases have no clearly detected primary site despite intensive evaluation, and this incidence has decreased with the use of improved imaging technology. Radiosurgery has been evaluated as one of the treatment modality for patients with limited brain metastases. In this study, we evaluated the effectiveness of radiosurgery for brain metastases from unknown primary tumors. Methods We retrospectively evaluated 540 patients who underwent gamma knife radiosurgery (GKRS) for brain metastases radiologically diagnosed between August 1992 and September 2007 in our institution. First, the brain metastases were grouped into metachronous, synchronous, and precocious presentations according to the timing of diagnosis of the brain metastases. Then, synchronous and precocious brain metastases were further grouped into 1) unknown primary; 2) delayed known primary; and 3) synchronous metastases according to the timing of diagnosis of the primary origin. We analyzed the survival time and time to new brain metastasis in each group. Results Of the 540 patients, 29 (5.4%) presented precocious or synchronous metastases (34 GKRS procedures for 174 lesions). The primary tumor was not found even after intensive and repeated systemic evaluation in 10 patients (unknown primary, 34.5%); found after 8 months in 3 patients (delayed known primary, 1.2%); and diagnosed at the same time as the brain metastases in 16 patients (synchronous metastasis, 55.2%). No statistically significant differences in survival time and time to new brain metastasis were found among the three groups. Conclusion Identification of a primary tumor before GKRS did not affect the patient outcomes. If other possible differential diagnoses were completely excluded, early GKRS can be an effective treatment option for brain metastases from unknown primary tumor. PMID:27867920

Neuroendocrine Merkel cell nodal carcinoma of unknown primary site: management and outcomes of a rare entity.

PubMed

Kotteas, E A; Pavlidis, N

2015-04-01

Merkel cell nodal carcinoma of unknown primary (MCCUP) is a rare neuroendocrine tumour with distinct clinical and biological behaviour. We conducted a review of retrospective data extracted from 90 patients focusing on the management and outcome of this disease. We also compared life expectancy of these patients with the outcome of patients with known Merkel primaries and with neuroendocrine cancers of unidentifiable primary. There is a limited body of data for this type of malignancy, however, patients with Merkel cell nodal carcinoma of unknown primary site, seem to have better survival when treated aggressively than patients with cutaneous Merkel tumours of the same stage and equal survival with patients with low-grade neuroendocrine tumour of unknown origin. The lack of prospective trials, and the inadequate data, hamper the management of these tumours. Establishment of treatment guidelines is urgently needed. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.

PubMed

Demeulemeester, Jonas; Kumar, Parveen; Møller, Elen K; Nord, Silje; Wedge, David C; Peterson, April; Mathiesen, Randi R; Fjelldal, Renathe; Zamani Esteki, Masoud; Theunis, Koen; Fernandez Gallardo, Elia; Grundstad, A Jason; Borgen, Elin; Baumbusch, Lars O; Børresen-Dale, Anne-Lise; White, Kevin P; Kristensen, Vessela N; Van Loo, Peter; Voet, Thierry; Naume, Bjørn

2016-12-09

Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. We sequence the genomes of 63 single cells isolated from six non-metastatic breast cancer patients. By comparing the cells' DNA copy number aberration (CNA) landscapes with those of the primary tumors and lymph node metastasis, we establish that 53% of the single cells morphologically classified as tumor cells are DTCs disseminating from the observed tumor. The remaining cells represent either non-aberrant "normal" cells or "aberrant cells of unknown origin" that have CNA landscapes discordant from the tumor. Further analyses suggest that the prevalence of aberrant cells of unknown origin is age-dependent and that at least a subset is hematopoietic in origin. Evolutionary reconstruction analysis of bulk tumor and DTC genomes enables ordering of CNA events in molecular pseudo-time and traced the origin of the DTCs to either the main tumor clone, primary tumor subclones, or subclones in an axillary lymph node metastasis. Single-cell sequencing of bone marrow epithelial-like cells, in parallel with intra-tumor genetic heterogeneity profiling from bulk DNA, is a powerful approach to identify and study DTCs, yielding insight into metastatic processes. A heterogeneous population of CNA-positive cells is present in the bone marrow of non-metastatic breast cancer patients, only part of which are derived from the observed tumor lineages.

Real time gamma-ray signature identifier

DOEpatents

Rowland, Mark [Alamo, CA; Gosnell, Tom B [Moraga, CA; Ham, Cheryl [Livermore, CA; Perkins, Dwight [Livermore, CA; Wong, James [Dublin, CA

2012-05-15

A real time gamma-ray signature/source identification method and system using principal components analysis (PCA) for transforming and substantially reducing one or more comprehensive spectral libraries of nuclear materials types and configurations into a corresponding concise representation/signature(s) representing and indexing each individual predetermined spectrum in principal component (PC) space, wherein an unknown gamma-ray signature may be compared against the representative signature to find a match or at least characterize the unknown signature from among all the entries in the library with a single regression or simple projection into the PC space, so as to substantially reduce processing time and computing resources and enable real-time characterization and/or identification.

Metabolic screening and metabolomics analysis in the Intellectual Developmental Disorders Mexico Study.

PubMed

Ibarra-González, Isabel; Rodríguez-Valentín, Rocío; Lazcano-Ponce, Eduardo; Vela-Amieva, Marcela

2017-01-01

Inborn errors of metabolism (IEM) are genetic conditions that are sometimes associated with intellectual developmental disorders (IDD). The aim of this study is to contribute to the metabolic characterization of IDD of unknown etiology in Mexico. Metabolic screening using tandem mass spectrometry and fluorometry will be performed to rule out IEM. In addition, target metabolomic analysis will be done to characterize the metabolomic profile of patients with IDD. Identification of new metabolomic profiles associated with IDD of unknown etiology and comorbidities will contribute to the development of novel diagnostic and therapeutic schemes for the prevention and treatment of IDD in Mexico.

Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study.

PubMed

Naito, Toshio; Mizooka, Masafumi; Mitsumoto, Fujiko; Kanazawa, Kenji; Torikai, Keito; Ohno, Shiro; Morita, Hiroyuki; Ukimura, Akira; Mishima, Nobuhiko; Otsuka, Fumio; Ohyama, Yoshio; Nara, Noriko; Murakami, Kazunari; Mashiba, Kouichi; Akazawa, Kenichiro; Yamamoto, Koji; Senda, Shoichi; Yamanouchi, Masashi; Tazuma, Susumu; Hayashi, Jun

2013-12-20

Fever of unknown origin (FUO) can be caused by many diseases, and varies depending on region and time period. Research on FUO in Japan has been limited to single medical institution or region, and no nationwide study has been conducted. We identified diseases that should be considered and useful diagnostic testing in patients with FUO. A nationwide retrospective study. 17 hospitals affiliated with the Japanese Society of Hospital General Medicine. This study included patients ≥18 years diagnosed with 'classical fever of unknown origin' (axillary temperature ≥38°C at least twice over a ≥3-week period without elucidation of a cause at three outpatient visits or during 3 days of hospitalisation) between January and December 2011. A total of 121 patients with FUO were enrolled. The median age was 59 years (range 19-94 years). Causative diseases were infectious disease in 28 patients (23.1%), non-infectious inflammatory disease in 37 (30.6%), malignancy in 13 (10.7%), other in 15 (12.4%) and unknown in 28 (23.1%). The median interval from fever onset to evaluation at each hospital was 28 days. The longest time required for diagnosis involved a case of familial Mediterranean fever. Tests performed included blood cultures in 86.8%, serum procalcitonin in 43.8% and positron emission tomography in 29.8% of patients. With the widespread use of CT, FUO due to deep-seated abscess or solid tumour is decreasing markedly. Owing to the influence of the ageing population, polymyalgia rheumatica was the most frequent cause (9 patients). Four patients had FUO associated with HIV/AIDS, an important cause of FUO in Japan. In a relatively small number of cases, cause remained unclear. This may have been due to bias inherent in a retrospective study. This study identified diseases that should be considered in the differential diagnosis of FUO.

Prevalence of scrub typhus in pyrexia of unknown origin and assessment of interleukin-8, tumor necrosis factor-alpha, and interferon-gamma levels in scrub typhus-positive patients.

PubMed

Rizvi, Meher; Sultan, Asfia; Chowdhry, Madhav; Azam, Mohd; Khan, Fatima; Shukla, Indu; Khan, Haris M

2018-01-01

Scrub typhus is lesser known cause of fever of unknown origin in India. Even if there have been reports documenting the prevalence of scrub typhus in different parts of India, it is still an unknown entity, and clinicians usually do not consider it as differential diagnosis. The present study was performed to document the prevalence of scrub typhus among febrile patients in western part of Uttar Pradesh and to assess the clinical profile of infected patients on the one hand and knowledge, attitude, and practices among clinicians on the other. A total of 357 adult patients with fever of more than 5-day duration were recruited. All patients underwent complete physical examination, and detailed clinical history was elicited as per predesigned pro forma. After primary screening to rule out malaria, enteric fever, and leptospirosis infection, secondary screening for scrub typhus was done by rapid screen test and IgM ELISA. Scrub typhus infection was positive in 91 (25.5%) cases. The most common symptoms among the patients were fever (100%), pain in abdomen (79.1%), pedal edema 56 (61.5%), rash 44 (48.3%), headache 44 (48.3%), vomiting 42 (46.1%), constipation 33 (36.2%), cough 28 (30.7%), and lymphadenopathy 20 (21.9%). The median values of interleukin-8, interferon-gamma, and tumor necrosis factor-alpha in healthy controls were 15.54 pg/ml, 7.77 pg/ml, and 54.1 pg/ml, respectively, while the median values of these cytokines in scrub typhus-positive patients were 21.04 pg/ml, 8.74 pg/ml, and 73.8 pg/ml, respectively. Our results highlight that scrub typhus infection is an important cause of pyrexia of unknown origin, and active surveillance is necessary to assess the exact magnitude and distribution of the disease.

Feline urine metabolomic signature: characterization of low-molecular-weight substances in urine from domestic cats.

PubMed

Rivera-Vélez, Sol-Maiam; Villarino, Nicolas F

2018-02-01

Objectives This aim of this study was to characterize the composition and content of the feline urine metabolome. Methods Eight healthy domestic cats were acclimated at least 10 days before starting the study. Urine samples (~2 ml) were collected by ultrasound-guided cystocentesis. Samples were centrifuged at 1000 × g for 8 mins, and the supernatant was analyzed by gas chromatography/time-of-flight mass spectrometery. The urine metabolome was characterized using an untargeted metabolomics approach. Results Three hundred and eighteen metabolites were detected in the urine of the eight cats. These molecules are key components of at least 100 metabolic pathways. Feline urine appears to be dominated by carbohydrates, carbohydrate conjugates, organic acid and derivatives, and amino acids and analogs. The five most abundant molecules were phenaceturic acid, hippuric acid, pseudouridine phosphate and 3-(4-hydroxyphenyl) propionic acid. Conclusions and relevance This study is the first to characterize the feline urine metabolome. The results of this study revealed the presence of multiple low-molecular-weight substances that were not known to be present in feline urine. As expected, the origin of the metabolites detected in urine was diverse, including endogenous compounds and molecules biosynthesized by microbes. Also, the diet seemed to have had a relevant role on the urine metabolome. Further exploration of the urine metabolic phenotype will open a window for discovering unknown, or poorly understood, metabolic pathways. In turn, this will advance our understanding of feline biology and lead to new insights in feline physiology, nutrition and medicine.

Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation.

PubMed

Ali, Shah R; Ranjbarvaziri, Sara; Talkhabi, Mahmood; Zhao, Peng; Subat, Ali; Hojjat, Armin; Kamran, Paniz; Müller, Antonia M S; Volz, Katharina S; Tang, Zhaoyi; Red-Horse, Kristy; Ardehali, Reza

2014-09-12

Fibrosis is mediated partly by extracellular matrix-depositing fibroblasts in the heart. Although these mesenchymal cells are reported to have multiple embryonic origins, the functional consequence of this heterogeneity is unknown. We sought to validate a panel of surface markers to prospectively identify cardiac fibroblasts. We elucidated the developmental origins of cardiac fibroblasts and characterized their corresponding phenotypes. We also determined proliferation rates of each developmental subset of fibroblasts after pressure overload injury. We showed that Thy1(+)CD45(-)CD31(-)CD11b(-)Ter119(-) cells constitute the majority of cardiac fibroblasts. We characterized these cells using flow cytometry, epifluorescence and confocal microscopy, and transcriptional profiling (using reverse transcription polymerase chain reaction and RNA-seq). We used lineage tracing, transplantation studies, and parabiosis to show that most adult cardiac fibroblasts derive from the epicardium, a minority arises from endothelial cells, and a small fraction from Pax3-expressing cells. We did not detect generation of cardiac fibroblasts by bone marrow or circulating cells. Interestingly, proliferation rates of fibroblast subsets on injury were identical, and the relative abundance of each lineage remained the same after injury. The anatomic distribution of fibroblast lineages also remained unchanged after pressure overload. Furthermore, RNA-seq analysis demonstrated that Tie2-derived and Tbx18-derived fibroblasts within each operation group exhibit similar gene expression profiles. The cellular expansion of cardiac fibroblasts after transaortic constriction surgery was not restricted to any single developmental subset. The parallel proliferation and activation of a heterogeneous population of fibroblasts on pressure overload could suggest that common signaling mechanisms stimulate their pathological response. © 2014 American Heart Association, Inc.

Characterization of noradrenaline release in the locus coeruleus of freely moving awake rats by in vivo microdialysis.

PubMed

Fernández-Pastor, Begoña; Mateo, Yolanda; Gómez-Urquijo, Sonia; Javier Meana, J

2005-07-01

The origin and regulation of noradrenaline (NA) in the locus coeruleus (LC) is unknown. The neurochemical features of NA overflow (nerve impulse dependence, neurotransmitter synthesis, vesicle storage, reuptake, alpha2-adrenoceptor-mediated regulation) were characterized in the LC. Brain microdialysis was performed in awake rats. Dialysates were analyzed for NA. NA in the LC decreased via local infusion of Ca2+-free medium (-42+/-5%) or the sodium channel blocker tetrodotoxine (TTX) (-47+/-8%) but increased (333+/-40%) via KCl-induced depolarization. The tyrosine hydroxylase (TH) inhibitor alpha-methyl-p-tyrosine (250 mg kg(-1), i.p.) and the vesicle depletory drug reserpine (5 mg kg(-1), i.p.) decreased NA. Therefore, extracellular NA in the LC satisfies the criteria for an impulse flow-dependent vesicular exocytosis of neuronal origin. Local perfusion of the alpha2-adrenoceptor agonist clonidine (0.1-100 microM) decreased NA (E(max)=-79+/-5%) in the LC, whereas the opposite effect (E(max)=268+/-53%) was observed with the alpha2A-adrenoceptor antagonist BRL44408 (0.1-100 microM). This suggests a tonic modulation of NA release through local alpha2A-adrenoceptors. The selective NA reuptake inhibitor desipramine (DMI) (0.1-100 microM) administered into the LC increased NA in the LC (E(max)=223+/-40%) and simultaneously decreased NA in the cingulate cortex, confirming the modulation exerted by NA in the LC on firing activity of noradrenergic cells and on the subsequent NA release in noradrenergic terminals. Synaptic processes underlying NA release in the LC are similar to those in noradrenergic terminal areas. NA in the LC could represent local somatodendritic release, but also the presence of neurotransmitter release from collateral axon terminals.

Production and transformation of dissolved neutral sugars and amino acids by bacteria in seawater

NASA Astrophysics Data System (ADS)

Jørgensen, L.; Lechtenfeld, O. J.; Benner, R.; Middelboe, M.; Stedmon, C. A.

2014-10-01

Dissolved organic matter (DOM) in the ocean consists of a heterogeneous mixture of molecules, most of which are of unknown origin. Neutral sugars and amino acids are among the few recognizable biomolecules in DOM, and the molecular composition of these biomolecules is shaped primarily by biological production and degradation processes. This study provides insight into the bioavailability of biomolecules as well as the chemical composition of DOM produced by bacteria. The molecular compositions of combined neutral sugars and amino acids were investigated in DOM produced by bacteria and in DOM remaining after 32 days of bacterial degradation. Results from bioassay incubations with natural seawater (sampled from water masses originating from the surface waters of the Arctic Ocean and the North Atlantic Ocean) and artificial seawater indicate that the molecular compositions following bacterial degradation are not strongly influenced by the initial substrate or bacterial community. The molecular composition of neutral sugars released by bacteria was characterized by a high glucose content (47 mol %) and heterogeneous contributions from other neutral sugars (3-14 mol %). DOM remaining after bacterial degradation was characterized by a high galactose content (33 mol %), followed by glucose (22 mol %) and the remaining neutral sugars (7-11 mol %). The ratio of D-amino acids to L-amino acids increased during the experiments as a response to bacterial degradation, and after 32 days, the D/L ratios of aspartic acid, glutamic acid, serine and alanine reached around 0.79, 0.32, 0.30 and 0.51 in all treatments, respectively. The striking similarity in neutral sugar and amino acid compositions between natural (representing marine semi-labile and refractory DOM) and artificial (representing bacterially produced DOM) seawater samples, suggests that microbes transform bioavailable neutral sugars and amino acids into a common, more persistent form.

Characterization of unknown brominated disinfection byproducts during chlorination using ultrahigh resolution mass spectrometry.

PubMed

Zhang, Haifeng; Zhang, Yahe; Shi, Quan; Zheng, Hongdie; Yang, Min

2014-03-18

Brominated disinfection byproducts (Br-DBPs), formed from the reaction of disinfectant(s) with natural organic matter in the presence of bromide in raw water, are generally more cytotoxic and genotoxic than their chlorinated analogues. To date, only a few Br-DBPs in drinking water have been identified, while a significant portion of Br-DBPs in drinking water is still unknown. In this study, negative ion electrospray ionization ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) was used to characterize unknown Br-DBPs in artificial drinking water. In total, 441 formulas for one-bromine-containing products and 37 formulas for two-bromine-containing products, most of which had not been previously reported, were detected in the chlorinated sample. Most Br-DBPs have corresponding chlorine-containing analogues with identical CHO composition. In addition, on-resonance collision-induced dissociation (CID) of single ultrahigh resolved bromine containing mass peaks was performed in the ICR cell to isolate single bromine-containing components in a very complex natural organic matter spectrum and provide structure information. Relatively abundant neutral loss of CO2 was observed in MS-MS spectra, indicating that the unknown Br-DBPs are rich in carboxyl groups. The results demonstrate that the ESI FT-ICR MS method could provide valuable molecular composition and structure information on unknown Br-DBPs.

9. Photocopy of old photo shows a general view of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of old photo shows a general view of the church, date unknown, Original photograph at Idaho Historical Society, Boise, Idaho - St. Joseph's Roman Catholic Church, High & Wallula Streets, Idaho City, Boise County, ID

Arsia Mons Ripples

NASA Image and Video Library

2012-02-17

This image captured by NASA 2001 Mars Odyssey spacecraft shows a series of low, concentric ridges is located to the west of Arsia Mons. The origin of these features is unknown, and there are no similar features at the other Tharsis volcanoes.

Estimation of time- and state-dependent delays and other parameters in functional differential equations

NASA Technical Reports Server (NTRS)

Murphy, K. A.

1988-01-01

A parameter estimation algorithm is developed which can be used to estimate unknown time- or state-dependent delays and other parameters (e.g., initial condition) appearing within a nonlinear nonautonomous functional differential equation. The original infinite dimensional differential equation is approximated using linear splines, which are allowed to move with the variable delay. The variable delays are approximated using linear splines as well. The approximation scheme produces a system of ordinary differential equations with nice computational properties. The unknown parameters are estimated within the approximating systems by minimizing a least-squares fit-to-data criterion. Convergence theorems are proved for time-dependent delays and state-dependent delays within two classes, which say essentially that fitting the data by using approximations will, in the limit, provide a fit to the data using the original system. Numerical test examples are presented which illustrate the method for all types of delay.

The Five Year Fermi/GBM Magnetar Burst Catalog

NASA Astrophysics Data System (ADS)

Collazzi, A. C.; Kouveliotou, C.; van der Horst, A. J.; Younes, G. A.; Kaneko, Y.; Göğüş, E.; Lin, L.; Granot, J.; Finger, M. H.; Chaplin, V. L.; Huppenkothen, D.; Watts, A. L.; von Kienlin, A.; Baring, M. G.; Gruber, D.; Bhat, P. N.; Gibby, M. H.; Gehrels, N.; McEnery, J.; van der Klis, M.; Wijers, R. A. M. J.

2015-05-01

Since launch in 2008, the Fermi Gamma-ray Burst Monitor (GBM) has detected many hundreds of bursts from magnetar sources. While the vast majority of these bursts have been attributed to several known magnetars, there is also a small sample of magnetar-like bursts of unknown origin. Here, we present the Fermi/GBM magnetar catalog, providing the results of the temporal and spectral analyses of 440 magnetar bursts with high temporal and spectral resolution. This catalog covers the first five years of GBM magnetar observations, from 2008 July to 2013 June. We provide durations, spectral parameters for various models, fluences, and peak fluxes for all the bursts, as well as a detailed temporal analysis for SGR J1550-5418 bursts. Finally, we suggest that some of the bursts of unknown origin are associated with the newly discovered magnetar 3XMM J185246.6+0033.7.

Boudot's Range-Bounded Commitment Scheme Revisited

NASA Astrophysics Data System (ADS)

Cao, Zhengjun; Liu, Lihua

Checking whether a committed integer lies in a specific interval has many cryptographic applications. In Eurocrypt'98, Chan et al. proposed an instantiation (CFT Proof). Based on CFT, Boudot presented a popular range-bounded commitment scheme in Eurocrypt'2000. Both CFT Proof and Boudot Proof are based on the encryption E(x, r)=g^xh^r mod n, where n is an RSA modulus whose factorization is unknown by the prover. They did not use a single base as usual. Thus an increase in cost occurs. In this paper, we show that it suffices to adopt a single base. The cost of the modified Boudot Proof is about half of that of the original scheme. Moreover, the key restriction in the original scheme, i.e., both the discrete logarithm of g in base h and the discrete logarithm of h in base g are unknown by the prover, which is a potential menace to the Boudot Proof, is definitely removed.

Fever of unknown origin (FUO) in an elderly adult due to Epstein-Barr virus (EBV) presenting as "typhoidal mononucleosis," mimicking a lymphoma.

PubMed

Cunha, Burke A; Petelin, Andrew; George, Sonia

2013-01-01

We describe fever of unknown origin (FUO) in a 57-year-old woman with hepatosplenomegaly. The diagnostic workup was directed at diagnosing a lymphoma. Her history of travel and exposures to food and water did not make typhoid fever a likely diagnostic possibility. Because she presented with prolonged fevers, fatigue, anorexia, weight loss, and night sweats with hepatosplenomegaly, lymphoma was likely. Initially, Epstein-Barr virus (EBV) was not considered because of her age, the absence of pharyngitis and cervical adenopathy, and the higher likelihood of another diagnosis, ie, lymphoma. Eventually, her FUO was diagnosed as EBV presenting as "typhoidal mononucleosis." Typhoidal mononucleosis is an extremely rare presentation of EBV as a cause of FUO in an adult. All of her symptoms as well as her clinical and laboratory findings resolved spontaneously. Copyright © 2013 Elsevier Inc. All rights reserved.

Endocarditis due to Rhodotorula mucilaginosa in a kidney transplanted patient: case report and review of medical literature.

PubMed

Cabral, Andrea Maria; da Siveira Rioja, Suzimar; Brito-Santos, Fabio; Peres da Silva, Juliana Ribeiro; MacDowell, Maria Luíza; Melhem, Marcia S C; Mattos-Guaraldi, Ana Luíza; Hirata Junior, Raphael; Damasco, Paulo Vieira

2017-11-01

Introduction. Endocarditis caused by yeasts is currently an emerging cause of infective endocarditis and, when accompanied byfever of unknown origin, is more severe since interferes with proper diagnosis and endocarditis treatment. Case presentation. The Rio de Janeiro Infective Endocarditis Study Group reports a case of infectious endocarditis (IE) with negative blood cultures in a 45-year-old white female resident in Rio de Janeiro, Brazil, previously submitted to kidney transplantation. After diagnosis and intervention, the valve culture revealed Rhodotorula mucilaginosa . The clinical aspects and overview of endocarditis caused by Rhodotorula spp. demonstrated that R. muscilaginosa have been isolated from the last IE cases from kidney transplanted patients. Conclusion. Though most of the patients (in literature) recovered well from endocarditis caused by Rhodotorula spp., physicians must be aware for diagnosis of fungemia and fungal treatment in kidney transplanted patients suffering of fever of unknown origin in the modern immunosuppressive treatment.

Estimation of time- and state-dependent delays and other parameters in functional differential equations

NASA Technical Reports Server (NTRS)

Murphy, K. A.

1990-01-01

A parameter estimation algorithm is developed which can be used to estimate unknown time- or state-dependent delays and other parameters (e.g., initial condition) appearing within a nonlinear nonautonomous functional differential equation. The original infinite dimensional differential equation is approximated using linear splines, which are allowed to move with the variable delay. The variable delays are approximated using linear splines as well. The approximation scheme produces a system of ordinary differential equations with nice computational properties. The unknown parameters are estimated within the approximating systems by minimizing a least-squares fit-to-data criterion. Convergence theorems are proved for time-dependent delays and state-dependent delays within two classes, which say essentially that fitting the data by using approximations will, in the limit, provide a fit to the data using the original system. Numerical test examples are presented which illustrate the method for all types of delay.

9. Photographic copy of photograph, dated June 1971 (original print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photographic copy of photograph, dated June 1971 (original print in possession of James E. Zielinski, Earth Tech, Huntsville, AL). Photographer unknown. View of sprint missile silo liners, prior to their installation within the subsurface holes at the missile launch site (June 1971). Not the silo liner at right; atop this is the launch preparation equipment chamber (LPEC). - Stanley R. Mickelsen Safeguard Complex, Missile Launch Area, Within Exclusion Area, Nekoma, Cavalier County, ND

41. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer and date unknown. Sand and gravel screening equipment used during the construction of the slow sand filter circa 1903. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

45. Photocopy of photograph (original negative is property of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

45. Photocopy of photograph (original negative is property of the Central Connecticut Regional Water Authority and preserved in their archives at 90 Sargent Drive, New Haven, Connecticut 06511-5966), photographer unknown, circa 1957. View of the northeast of the slow sand filter looking toward Whitney Avenue and east rock. - Lake Whitney Water Filtration Plant, Filtration Plant, South side of Armory Street between Edgehill Road & Whitney Avenue, Hamden, New Haven County, CT

8. Photocopy of printed page (original Page 30 of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Photocopy of printed page (original Page 30 of the Souvenir Program 1867-1967 Ridgely Centennial) Photographer unknown. Circa 1967. VIEW NORTHEAST, SOUTHWEST FRONT Ridgely's centennial was celebrated in 1967 and included in the souvenir brochure was page 30. This view shows the subject building with the 1950 modifications to provide for automotive traffic. It was a print of a current photograph. - 510 Central Avenue (Commercial Building), Ridgely, Caroline County, MD

19. Photocopy of photograph (original copy in Edison collection). Photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. Photocopy of photograph (original copy in Edison collection). Photographer and date unknown, although probably taken before 1920. SOUTH SIDE OF TULE RIVER POWERHOUSE COMPLEX SHOWING OPERATOR COTTAGE AT PHOTO RIGHT AND POWERHOUSE AND TRANSFORMER BUILDING IN BACKGROUND AT PHOTO LEFT. LINE OF BURIED PENSTOCK IS VISIBLE ON SIDE OF HILL AT PHOTO CENTER. VIEW TO NORTH. - Tule River Hydroelectric Project, Water Conveyance System, Middle Fork Tule River, Springville, Tulare County, CA

28. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1927, photographer unknown 2 3/8 X 4 inch negative RIVER WALL ON THE NORTH SIDE, JUST WEST (DOWNSTREAM) OF THE COVERED FOOTBRIDGE. THE FIRE PUMP HOUSE (1927) AND BOILER ROOM (1919) OF THE SULLIVAN MACHINERY COMPANY ARE ALSO VISIBLE. - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH

14. Photocopy of photograph (original 43/4 x 33/4 inch print ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of photograph (original 4-3/4 x 3-3/4 inch print located in the Recreation files, Mt. Baker-Snoqualmie N. F.). Photographer unknown, ca. 1941 AUSTIN PASS SKI HUT (WITH BAGLEY LAKE BELOW) AT HEATHER MEADOWS RECREATION AREA. WIDE-CONED MOUNTAIN IN CENTER BACKGROUND IS MOUNT LARRABEE; CANADIAN RED MOUNTAIN IS PEAK TO LEFT. GLACIER DISTRICT. - Austin Pass Warming Hut, Washington Highway 542, Glacier, Whatcom County, WA

14. Photographic copy of photograph, dated 21 July 1971 (original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photographic copy of photograph, dated 21 July 1971 (original print in possession of U.S. Space & Strategic Defense Command Historic Office CSSD-HO, Huntsville, AL). Photographer unknown. View of missile site control building turret wall during early construction, illustrating the massive amount of rebar utilized in the project. - Stanley R. Mickelsen Safeguard Complex, Missile Site Control Building, Northeast of Tactical Road; southeast of Tactical Road South, Nekoma, Cavalier County, ND

17. Photocopy of photograph (original slide in possession of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of photograph (original slide in possession of the Preservation Society of Charleston, Charleston, South Carolina; Collection of Dr. and Mrs. E. L. Powers, Charleston, South Carolina) Photographer and date unknown SOUTH FRONT (CENTER OF PHOTOGRAPH), LOOKING NORTH; 92 BROAD STREET VISIBLE AT LEFT EDGE OF PHOTOGRAPH, OLD JEWISH ORPHANAGE (HABS NO. SC-13-15) VISIBLE AT RIGHT EDGE OF PHOTOGRAPH - 90 Broad Street (Commercial Building), Charleston, Charleston County, SC

A new component of cosmic rays of unknown origin at a few MeV per nucleon

NASA Technical Reports Server (NTRS)

Gloecker, G.

1974-01-01

Recently discovered anomalies in the abundances and energy spectra of quiet time, extraterrestrial hydrogen, helium, carbon, nitrogen, and oxygen require serious revisions of origin theories to account for this new component of cosmic radiation. Abnormally large O/C and N/C ratios, long term intensity variations with time, and radial gradient measurements indicate a non-solar origin for these 2 to 30 MeV/nucleon particles. Ideas suggested to explain these measurements range from acceleration of galactic source material having an unusual composition to local acceleration of particles within the solar cavity. Observations are at present insufficient to choose between these alternate origin models.

8” x 10” and white photographic print made from original ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8” x 10” and white photographic print made from original 1935, 8” x 10” black and white photographic negative. New 4” x 5” archival negative made from print. Original photographer unknown. Original 8” x 10” negative located in the files of the New Orleans Public Belt Railroad administrative offices at 5100 Jefferson Highway, Jefferson, LA 70123. JANUARY 28, 1935 PHOTOGRAPH NO. 72 OF CONTRACT NO. 4 SHOWING BRIDGE SUPERSTRUCTURE COMPLETED HIGHWAY SLAB BETWEEN PIERS V TO B. - Huey P. Long Bridge, Spanning Mississippi River approximately midway between nine & twelve mile points upstream from & west of New Orleans, Jefferson, Jefferson Parish, LA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doyle, Jamie L.; Kuhn, Kevin John; Byerly, Benjamin

Nuclear forensic publications, performance tests, and research and development efforts typically target the bulk global inventory of intentionally safeguarded materials, such as plutonium (Pu) and uranium (U). Other materials, such as neptunium (Np), pose a nuclear security risk as well. Trafficking leading to recovery of an interdicted Np sample is a realistic concern especially for materials originating in countries that reprocesses fuel. Using complementary forensic methods, potential signatures for an unknown Np oxide sample were investigated. Measurement results were assessed against published Np processes to present hypotheses as to the original intended use, method of production, and origin for thismore » Np oxide.« less

Historic view just west of powerhouse during reconstruction of penstocks ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Historic view just west of powerhouse during reconstruction of penstocks and replacement of original Francis Turbine with pelton wheels, in 1912; looking northwest. (photographer unknown, ca. 1912.) - Nooksack Falls Hydroelectric Plant, Route 542, Glacier, Whatcom County, WA