Hydrostatic temperature calculations. [in synoptic meteorology

NASA Technical Reports Server (NTRS)

Raymond, William H.

1987-01-01

Comparisons are made between hydrostatically computed temperatures and ambient temperatures associated with nine different data sources, including analyses, forecasts and conventional observations. Five-day averages and the day-to-day variations in the root-mean-square temperature differences are presented. Several different numerical and interpolation procedures are examined. Error correction and a constrained optimum procedure that minimizes ambient minus calculated hydrostatic temperature differences are introduced. Systematic differences between ambient and hydrostatic temperatures are found to be associated with the sinoptic situation. When compared with ambient temperatures, hydrostatic temperatures at 500 mb tend to be too warm at or in front of a trough and too cold behind the trough. In the vertical direction, for the eight-level configuration tested, the average hydrostatic temperatures are too cold at low levels (850, 700 mb) and too warm at upper levels, (300, 250 mb).

An extreme dust storm over the Arabian Peninsula in Spring 2015: the role of convective mixing and vortex stretching

NASA Astrophysics Data System (ADS)

Hauser, Seraphine; Pante, Gregor; Pantillon, Florian; Knippertz, Peter

2017-04-01

The Arabian Peninsula is one of the World's largest dust sources. Severe dust storms occur throughout the year dominated by synoptic-scale driven frontal systems in winter and spring and convective systems during summer and autumn. Dust storm frequency peaks in spring, when extra-tropical upper-level troughs associated with near-surface cold fronts regularly penetrate into the peninsula. In this study we investigate the dynamics of an extreme springtime dust event, which covered the entire Arabian Peninsula and the adjacent Indian Ocean in early April 2015. In addition to the more common trough/frontal characteristics, EUMETSAT's false-colour dust product shows a striking vortex-like structure during the initial state of the storm. Several SYNOP stations on the Arabian Peninsula report severe dust storms, rapid temperature drop, strong increase in wind speed up to 40 kn and zero visibility for several hours on 01 and 02 April. Remarkably also, 61 mm of rainfall are observed on 01 April at the station Arar in northern Saudi Arabia (annual average 52 mm), clearly indicating a convective contribution to this event. Some evidence for significant precipitation is also found in satellite products. Operational analyses of the European Centre for Medium-Range Weather Forecasts (ECMWF) show a distinct short-wave upper-level trough swiftly propagating across the region during this period, accompanied by high relative vorticity values of up to 10 times the planetary vorticity. This vorticity is associated with the trough's curvature, but also with the large cyclonic shear at the northern side of the subtropical jet. The passage of the upper-level disturbance is well timed to overpass the region of the Arabian Peninsula heat low around midday, where vorticity is thermally generated. Most likely the deep boundary layer facilitated the triggering of convection by the upper-level forcing. Ultimately, downward mixing of the high vorticity by convection plus vortex stretching cause exceptionally high vorticity near the surface, which initiated this extreme and unusual dust storm. Short-range ECMWF forecasts produce precipitation but not as extreme as measured at Arar. The model also generates strong near-surface winds, which are generally in good agreement with the SYNOP observations. Interestingly, however, the 10 m wind direction falls short to reflect the extreme cyclonic curvature evident in station observations, pointing to an underestimation of the vortex in the model. We hypothesise that the ECMWF model with its parameterised convection is unable to realistically represent the vertical mixing and vortex stretching. Numerical simulations on the convection permitting scale might improve forecasts of such events, but this is yet to be tested.

Devonian salt dissolution-collapse breccias flooring the Cretaceous Athabasca oil sands deposit and development of lower McMurray Formation sinkholes, northern Alberta Basin, Western Canada

NASA Astrophysics Data System (ADS)

Broughton, Paul L.

2013-01-01

The sub-Cretaceous paleotopography underlying giant Lower Cretaceous Athabasca oil sands, northern Alberta, has an orthogonal lattice pattern of troughs up to 50 km long and 100 m deep between pairs of cross-cutting lineaments. These structures are interpreted to have been inherited from a similar pattern of dissolution collapse-subsidence troughs in the underlying Middle Devonian salt beds. Removal of more than 100 m of halite salt fragmented the overlying Upper Devonian strata into fault blocks and collapse breccias that subsided into the underlying dissolution troughs. The unusually low 1:2 to 1:3 thickness ratios of halite salts to the overlying strata resulted in the Upper Devonian strata collapse-subsidence into underlying salt dissolution troughs being more cataclysmic during the first phase of salt removal. The second phase of slower but complete salt removal between the earlier troughs resulted in a more gradual subsidence of the overlying strata. This obliterated the earlier pattern of giant cross-cutting dissolution troughs bounded by major lineaments. The collapse breccia fabrics underlying the earlier troughs differ from those from areas between the troughs. Collapse breccias underlying the large troughs often have crushed fabrics distributed in zones that rapidly pinched out between fault blocks. Breccias between troughs developed as giant mosaics of detached carbonate blocks that formed breccia pipe complexes. Multiple sinkholes up to 100 m deep aligned along multi-km linear valley trends that dissected the sub-Cretaceous paleotopography. These sinkhole trends formed orthogonal patterns inherited from underlying lattice of NW-SE and NE-SW salt structured lineaments. These cross-cutting sinkhole trends have a smaller 5 km scale reticulate pattern similar to the giant 50 km scale pattern of collapse-subsidence troughs. Other sinkholes developed as lower McMurray strata sagged when underlying Devonian fault blocks and breccia pipes differentially subsided.

Imaging of Upper-Mantle Upwelling Beneath the Salton Trough, Southern California, by Joint Inversion of Ambient Noise Dispersion Curves and Receiver Functions

NASA Astrophysics Data System (ADS)

Klemperer, S. L.; Barak, S.

2016-12-01

We present a new 2D shear-wave velocity model of the crust and upper-mantle across the Salton Trough, southern California, obtained by jointly inverting our new dataset of receiver functions and our previously published Rayleigh-wave group-velocity model (Barak et al., G-cubed, 2015), obtained from ambient-noise tomography. Our results show an upper-mantle low-velocity zone (LVZ) with Vs ≤4.2 km/s extending from the Elsinore Fault to the Sand Hills Fault, that together bracket the full width of major San Andreas dextral motion since its inception 6 Ma b.p., and underlying the full width of low topography of the Imperial Valley and Salton Trough. The lateral extent of the LVZ is coincident with the lateral extent of an upper-mantle anisotropic region interpreted as a zone of SAF-parallel melt pockets (Barak & Klemperer, Geology, 2016). The shallowest part of the LVZ is 40 km depth, coincident with S-receiver function images. The western part of the LVZ, between the Elsinore and San Jacinto faults (the region of greatest modern dextral slip), appears to continue to significantly greater depth; but a puzzling feature of our preliminary models is that the eastern part of the LVZ, from the San Jacinto Fault to the Sand Hills Fault, appears to be underlain by more-normalvelocity upper mantle (Vs ≥ 4.5 km/s) below 75 km depth. We compare our model to the current SCEC community models CVM-H and CVM-S, and to P-wave velocity models obtained by the active-source Salton Sea Imaging Project (SSIP). The hypothesized lower-crustal low-velocity zone beneath the Salton Trough in our previous model (Barak et al., G-cubed, 2015), there interpreted as a region of partial melt, is not supported by our new modeling. Melt may be largely absent from the lower crust of the Salton trough; but appears required in the upper mantle at depths as shallow as 40 km.

Morphodynamics of intertidal bars near a seawall on a macrotidal beach, Wissant Bay, northern France

NASA Astrophysics Data System (ADS)

Sedrati, M.; Anthony, E.

2009-04-01

Several studies on beaches with intertidal bar-trough (ridge-and-runnel) systems in settings with relatively large tidal ranges (> 3 m) have focused on cross-shore bar mobility; however a few recent studies have drawn attention to the potential role of longshore transport induced by a mix of wave-tide and wind-forced longshore currents in the morphodynamics of the bars and troughs. The aim of this paper is to briefly highlight the relationship between wind-forced currents on the shallow intertidal zone and rapid intertidal bar-trough morphological response on a macrotidal beach. Fieldwork was conduced on Wissant beach, Wissant Bay, northern France, from 7 to 23 March, 2006. During the experiment, the beach (oriented NE-SW) exhibited three intertidal bar-trough systems and the upper bar was directly attached to a seawall. Seven digital elevation models (DEMs) were generated from high-resolution topographic surveys. Hydrodynamic measurements were obtained from five currentmeters (2 S4 and 3 ADCP) deployed on the bars crests and on the upper beach trough. Wave characteristics were obtained from the measured time series by spectral analysis using Fast Fourier Transforms. Wind speed and direction on the beach were measured using a portable weather station. The mean wind speed and directions averaged every three hours highlight closely-spaced high-energy events during the experiment, with long phases of significant lateral wind stress (NE to ENE). The measured waves and currents showed rapid and strong response to both the changes in wind speed and direction. Longshore currents measured during the experiment on the upper intertidal bar-trough system showed a clear SW flow pattern in response to NE to ENE wind approach directions while the currents in the lower intertidal zone flowed northeastward during the flood, following the coastline, and southwestward during the ebb in response to the tidal current modulation. Strong longshore migration of the upper intertidal bar to the SW was observed during the course of this fieldwork. This longshore migration was attended by erosion of the upper beach in the northeast and accretion in the southwest. Bars in the lower intertidal zone were relatively stable. The SW migration process of the upper intertidal bar during the experiment occurred at rates that fluctuated with the intensity of the longshore current. The net beach volume over the experiment was quite stable, thus showing that morphological change, notably bar migration, simply reflected adjustments to hydrodynamic forcing without new sand inputs into the system. The findings of the present study suggest that cross-shore currents are subordinate to, and may even be mitigated by, wind-forced longshore flows on this beach. The importance of longshore transport on the upper beach is due to hydrodynamic forcing over the shallow depth, with the seawall playing a probable additional longshore canalization effect. Longshore transport should be considered as an essential element of the morphodynamics of bar-trough beaches subject to large tidal ranges and significant lateral wind stress.

A deterministic and stochastic velocity model for the Salton Trough/Basin and Range transition zone and constraints on magmatism during rifting

NASA Astrophysics Data System (ADS)

Larkin, Steven P.; Levander, Alan; Okaya, David; Goff, John A.

1996-12-01

As a high resolution addition to the 1992 Pacific to Arizona Crustal Experiment (PACE), a 45-km-long deep crustal seismic reflection profile was acquired across the Chocolate Mountains in southeastern California to illuminate crustal structure in the transition between the Salton Trough and the Basin and Range province. The complex seismic data are analyzed for both large-scale (deterministic) and fine-scale (stochastic) crustal features. A low-fold near-offset common-midpoint (CMP) stacked section shows the northeastward lateral extent of a high-velocity lower crustal body which is centered beneath the Salton Trough. Off-end shots record a high-amplitude diffraction from the point where the high velocity lower crust pinches out at the Moho. Above the high-velocity lower crust, moderate-amplitude reflections occur at midcrustal levels. These reflections display the coherency and frequency characteristics of reflections backscattered from a heterogeneous velocity field, which we model as horizontal intrusions with a von Kármán (fractal) distribution. The effects of upper crustal scattering are included by combining the mapped surface geology and laboratory measurements of exposed rocks within the Chocolate Mountains to reproduce the upper crustal velocity heterogeneity in our crustal velocity model. Viscoelastic finite difference simulations indicate that the volume of mafic material within the reflective zone necessary to produce the observed backscatter is about 5%. The presence of wavelength-scale heterogeneity within the near-surface, upper, and middle crust also produces a 0.5-s-thick zone of discontinuous reflections from a crust-mantle interface which is actually a first-order discontinuity.

Thermal and chemical variations of the Nigerian Benue trough lead-zinc-barite-fluorite deposits

NASA Astrophysics Data System (ADS)

Ogundipe, Ibukun Emmanuel

2017-08-01

The Benue trough is an intra-continental rift initiated in the Cretaceous during the opening of the South Atlantic Ocean. Lead-zinc-barite-fluorite mineralization occurs along the 600 km axis of the trough in three discrete sub-basins which coincide with the lower, middle and upper mineral districts of the Benue Valley. Lithologically these sub-basins are dominated by black carbonaceous shale in the Lower Benue, platform carbonates in the Middle Benue and sandstones in the Upper Benue. Micro-thermometric analysis of fluid inclusions in sphalerite, fluorite, barite and quartz have shown that each mineral district has its own unique thermal and chemical imprint. For example, the temperature can be bracketed between 109 °C and 160 °C for lower Benue, 89 °C-144 °C for the Middle Benue and 176 °C-254 °C for the Upper Benue. Chemical differentiation also exists between each mineral district with the Lower Benue having 22 wt % equivalent NaCl while the Middle and Upper Benue have 18 and 16 wt % equivalent NaCl respectively. This study shows that inter-district thermal and chemical variations exist between the ore-stage sulfide and post-sulfide gangue minerals of the entire Benue Valley. Similarly, intra-district thermal and chemical variations have also been observed among all the paragenetic minerals of each district. The thermal variations may be as a result of variations in the geothermal gradient accompanying continental rifting from one district to the other. The variations in the chemistry between the Lower Benue and the Upper Benue paragenic minerals may be as a result of the distinct lithological differences across the Benue Trough.

Sr isotope evidence for a lacustrine origin for the upper Miocene to Pliocene Bouse Formation, lower Colorado River trough, and implications for timing of Colorado Plateau uplift

USGS Publications Warehouse

Spencer, J.E.; Patchett, P.J.

1997-01-01

The upper Miocene to Pliocene Bouse Formation in the lower Colorado River trough, which consists largely of siltstone with basal tufa and marl, has been interpreted as estuarine on the basis of paleontology. This interpretation requires abrupt marine inundation that has been linked to early rifting in the Gulf of California and Salton trough. New strontium isotope measurements reported here from carbonates and invertebrate shells in the Bouse Formation reveal no evidence of marine water, but are consistent with deposition in a lake or chain of lakes fed by the Colorado River. Furthermore, the absence of a southward decrease in 87Sr/86Sr within the Bouse Formation does not support the estuarine model in which low 87Sr/86Sr marine Sr would have dominated the mouth of the hypothetical Bouse estuary. Elevation of originally marine 87Sr/86Sr in the Bouse Formation to its present level, due to postdepositional interaction with ground water, is unlikely because Sr from secondary calcite above, below, and within the Bouse Formation is consistently less radiogenic, not more, than Bouse marl and shells. In contrast to Bouse Sr, strontium from mollusks in tidal-flat and delta-front paleoenvironments in the contemporaneous Imperial Formation in the Salton trough and from the subsurface south of Yuma was derived from sea water and confirms the dominance of marine strontium near or at the mouth of the late Miocene to early Pliocene Colorado River. Inferred post-early Pliocene uplift of the Bouse Formation from below sea level to modern elevations of up to 550 m has been used to support a late Cenozoic uplift age for the nearby Colorado Plateau. This constraint on uplift timing is eliminated if the Bouse Formation is lacustrine.

The effects of thick sediment upon continental breakup: seismic imaging and thermal modeling of the Salton Trough, southern California

NASA Astrophysics Data System (ADS)

Han, L.; Hole, J. A.; Lowell, R. P.; Stock, J. M.; Fuis, G. S.; Driscoll, N. W.; Kell, A. M.; Kent, G. M.; Harding, A. J.; Gonzalez-Fernandez, A.; Lázaro-Mancilla, O.

2015-12-01

Continental rifting ultimately creates a deep accommodation space for sediment. When a major river flows into a late-stage rift, thick deltaic sediment can change the thermal regime and alter the mechanisms of extension and continental breakup. The Salton Trough, the northernmost rift segment of the Gulf of California plate boundary, has experienced the same extension as the rest of the Gulf, but is filled to sea level by sediment from the Colorado River. Unlike the southern Gulf, seafloor spreading has not initiated. Instead, seismicity, high heat flow, and minor volcanoes attest to ongoing rifting of thin, transitional crust. Recently acquired controlled-source seismic refraction and wide-angle reflection data in the Salton Trough provide constraints upon crustal architecture and active rift processes. The crust in the central Salton Trough is only 17-18 km thick, with a strongly layered but relatively one-dimensional structure for ~100 km in the direction of plate motion. The upper crust includes 2-4 km of Colorado River sediment. Crystalline rock below the sediment is interpreted to be similar sediment metamorphosed by the high heat flow and geothermal activity. Meta-sediment extends to at least 9 km depth. A 4-5 km thick layer in the middle crust is either additional meta-sediment or stretched pre-existing continental crust. The lowermost 4-5 km of the crust is rift-related mafic magmatic intrusion or underplating from partial melting in the hot upper mantle. North American lithosphere in the Salton Trough has been almost or completely rifted apart. The gap has been filled by ~100 km of new transitional crust created by magmatism from below and sedimentation from above. These processes create strong lithologic, thermal, and rheologic layering. While heat flow in the rift is very high, rapid sedimentation cools the upper crust as compared to a linear geotherm. Brittle extension occurs within new meta-sedimentary rock. The lower crust, in comparison, is maintained hot and weak by the overlying sedimentary thermal blanket. The lower crust stretches by ductile flow and magmatism is not localized. In this passive rift driven by distant plate motions, rapid sedimentation and its thermal effects delay final breakup of the crust and the onset of seafloor spreading.

Patient-reported non-adherence and immunosuppressant trough levels are associated with rejection after renal transplantation.

PubMed

Scheel, Jennifer; Reber, Sandra; Stoessel, Lisa; Waldmann, Elisabeth; Jank, Sabine; Eckardt, Kai-Uwe; Grundmann, Franziska; Vitinius, Frank; de Zwaan, Martina; Bertram, Anna; Erim, Yesim

2017-03-29

Different measures of non-adherence to immunosuppressant (IS) medication have been found to be associated with rejection episodes after successful transplantation. The aim of the current study was to investigate whether graft rejection after renal transplantation is associated with patient-reported IS medication non-adherence and IS trough level variables (IS trough level variability and percentage of sub-therapeutic IS trough levels). Patient-reported non-adherence, IS trough level variability, percentage of sub-therapeutic IS trough levels, and acute biopsy-proven late allograft rejections were assessed in 267 adult renal transplant recipients who were ≥12 months post-transplantation. The rate of rejection was 13.5%. IS trough level variability, percentage of sub-therapeutic IS trough levels as well as patient-reported non-adherence were all significantly and positively associated with rejection, but not with each other. Logistic regression analyses revealed that only the percentage of sub-therapeutic IS trough levels and age at transplantation remained significantly associated with rejection. Particularly, the percentage of sub-therapeutic IS trough levels is associated with acute rejections after kidney transplantation whereas IS trough level variability and patient-reported non-adherence seem to be of subordinate importance. Patient-reported non-adherence and IS trough level variables were not correlated; thus, non-adherence should always be measured in a multi-methodological approach. Further research concerning the best combination of non-adherence measures is needed.

Landslide in Coprates

NASA Technical Reports Server (NTRS)

2004-01-01

This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows part of a large landslide complex off the north wall of Coprates Chasma in the Valles Marineris trough complex. The wall of Coprates Chasma occupies much of the upper and middle portions of the image; the landslide lobes are on the trough floor in the bottom half of the image. Large boulders the size of houses can be seen on these landslide surfaces. This image is located near 13.9 S, 56.7 W. The picture covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the upper left.

Morphology and sedimentology of glacigenic submarine fans on the west Greenland continental margin

NASA Astrophysics Data System (ADS)

O'Cofaigh, Colm; Hogan, Kelly A.; Dowdeswell, Julian A.; Jennings, Anne E.; Noormets, Riko; Evans, Jeffrey

2014-05-01

Along the West Greenland continental margin adjoining Baffin Bay, bathymetric data show a series of large submarine fans located at the mouths of cross-shelf troughs. Two of these fans, the Uummannaq Fan and the Disko Fan are trough-mouth fans built largely of debris delivered from ice sheet outlets of the Greenland Ice Sheet during past glacial maxima. On the Uummannaq Fan glacigenic debris flow deposits occur on the upper slope and extend to at least 1800 m water depth in front of the trough-mouth. The debris flow deposits are related to the remobilisation of subglacial debris that was delivered onto the upper slope at times when an ice stream was positioned at the shelf edge. In contrast, sedimentary facies from the northern sector of the fan are characterised by hemipelagic and ice-rafted sediments and turbidites; glacigenic debris flows are notably absent in cores from this region. Further south along the Greenland continental margin the surface of the Disko Fan is prominently channelised and associated sediments are acoustically stratified. Although glacigenic debris flow deposits do occur on the upper Disko Fan, sediments recovered in cores from elsewhere on the fan record the influence of turbidity current and meltwater sedimentation. The channelised form of the Disko fan contrasts markedly with that of the Uummannaq Fan and, more widely, with trough mouth fans from the Polar North Atlantic. Collectively these data highlight the variability of glacimarine depositional processes operating on trough-mouth fans on high-latitude continental slopes and show that glacigenic debris flows are but one of a number of mechanisms by which such large glacially-influenced depocentres form.

Turbidite megabeds in an Oceanic Rift Valley recording jokulhlaups of late Pleistocene glacial lakes of the western United States

USGS Publications Warehouse

Zuffa, G.G.; Normark, W.R.; Serra, F.; Brunner, C.A.

2000-01-01

Escanaba Trough is the southernmost segment of the Gorda Ridge and is filled by sandy turbidites locally exceeding 500 m in thickness. New results from Ocean Drilling Program (ODP) Sites 1037 and 1038 that include accelerator mass spectrometry (AMS) 14C dates and revised petrographic evaluation of the sediment provenance, combined with high-resolution seismic-reflection profiles, provide a lithostratigraphic framework for the turbidite deposits. Three fining-upward units of sandy turbidites from the upper 365 m at ODP Site 1037 can be correlated with sediment recovered at ODP Site 1038 and Deep Sea Drilling Program (DSDP) Site 35. Six AMS 14C ages in the upper 317 m of the sequence at Site 1037 indicate that average deposition rates exceeded 10 m/k.yr. between 32 and 11 ka, with nearly instantaneous deposition of one ~60-m interval of sand. Petrography of the sand beds is consistent with a Columbia River source for the entire sedimentary sequence in Escanaba Trough. High-resolution acoustic stratigraphy shows that the turbidites in the upper 60 m at Site 1037 provide a characteristic sequence of key reflectors that occurs across the floor of the entire Escanaba Trough. Recent mapping of turbidite systems in the northeast Pacific Ocean suggests that the turbidity currents reached the Escanaba Trough along an 1100-km-long pathway from the Columbia River to the west flank of the Gorda Ridge. The age of the upper fining-upward unit of sandy turbidites appears to correspond to the latest Wisconsinan outburst of glacial Lake Missoula. Many of the outbursts, or jokulhlaups, from the glacial lakes probably continued flowing as hyperpycnally generated turbidity currents on entering the sea at the mouth of the Columbia River.

Complex Burial and Exhumation of South Polar Cap Pitted Terrain

NASA Technical Reports Server (NTRS)

2000-01-01

This image is illuminated by sunlight from the upper left. The two prominent bright stripes at the left/center of the image are covered with bright frost and thus create the illusion that they are sunlit from the lower left.

The large pits, troughs, and 'swiss cheese' of the south polar residual cap appear to have been formed in the upper 4 or 5 layers of the polar material. Each layer is approximately 2 meters (6.6 feet) thick. Some Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) images of this terrain show examples in which older pitted and eroded layers have been previously buried and are now being exhumed. The example shown here includes two narrow, diagonal slopes that trend from upper left toward lower right at the left/center portion of the frame. Along the bottoms of these slopes are revealed a layer that underlies them in which there are many more pits and troughs than in the upper layer. It is likely in this case that the lower layer formed its pits and troughs before it was covered by the upper layer. This observation suggests that the troughs, pits, and 'swiss cheese' features of the south polar cap are very old and form over long time scales.

The picture is located near 84.6oS, 45.1oW, and covers an area 3 km by 5 km (1.9 x 3.1 mi) at a resolution of about 3.8 meters (12 ft) per pixel. The image was taken during southern spring on August 29, 1999.

Malin Space Science Systems and the California Institute of Technology built the MOC using spare hardware from the Mars Observer mission. MSSS operates the camera from its facilities in San Diego, CA. The Jet Propulsion Laboratory's Mars Surveyor Operations Project operates the Mars Global Surveyor spacecraft with its industrial partner, Lockheed Martin Astronautics, from facilities in Pasadena, CA and Denver, CO.

Improved forecasts of winter weather extremes over midlatitudes with extra Arctic observations

NASA Astrophysics Data System (ADS)

Sato, Kazutoshi; Inoue, Jun; Yamazaki, Akira; Kim, Joo-Hong; Maturilli, Marion; Dethloff, Klaus; Hudson, Stephen R.; Granskog, Mats A.

2017-02-01

Recent cold winter extremes over Eurasia and North America have been considered to be a consequence of a warming Arctic. More accurate weather forecasts are required to reduce human and socioeconomic damages associated with severe winters. However, the sparse observing network over the Arctic brings errors in initializing a weather prediction model, which might impact accuracy of prediction results at midlatitudes. Here we show that additional Arctic radiosonde observations from the Norwegian young sea ICE expedition (N-ICE2015) drifting ice camps and existing land stations during winter improved forecast skill and reduced uncertainties of weather extremes at midlatitudes of the Northern Hemisphere. For two winter storms over East Asia and North America in February 2015, ensemble forecast experiments were performed with initial conditions taken from an ensemble atmospheric reanalysis in which the observation data were assimilated. The observations reduced errors in initial conditions in the upper troposphere over the Arctic region, yielding more precise prediction of the locations and strengths of upper troughs and surface synoptic disturbances. Errors and uncertainties of predicted upper troughs at midlatitudes would be brought with upper level high potential vorticity (PV) intruding southward from the observed Arctic region. This is because the PV contained a "signal" of the additional Arctic observations as it moved along an isentropic surface. This suggests that a coordinated sustainable Arctic observing network would be effective not only for regional weather services but also for reducing weather risks in locations distant from the Arctic.

Topography of Valles Marineris: Implications for erosional and structural history

NASA Technical Reports Server (NTRS)

Lucchitta, B. K.; Isbell, N. K.; Howington-Kraus, A.

1994-01-01

Compilation of a simplified geologic/geomorphic map onto digital terrain models of the Valles Marineris permitted an evaluation of elevations in the vicinity of the troughs and the calculation of depth of troughs below surrounding plateaus, thickness of deposits inside the troughs, volumes of void spaces above geologic/geomorphic units, and volumes of deposits. The central troughs north Ophir, north and central Candor, and north Melas Chasmata lie as much as 11 km below the adjacent plateaus. In Ophir and Candor chasmata, interior layered deposits reach 8 km in elevation. If the deposits are lacustrine and if all troughs were interconnected, lake waters standing 8 km high would have spilled out of Coprates Chasma onto the surrounding plateaus having surface elevations of only 4-5 km. On the other hand, the troughs may not have been interconnected at the time of interior-deposit emplacement; they may have formed isolated ancestral basins. The existence of such basins is supported by independent structural and stratigraphic evidence. The ancestral basins may have eventually merged, perhaps through renewed faulting, to form northern subsidiary troughs in Ophir and Candor Chasmata and the Coprates/north Melas/Ius graben system. The peripheral troughs are only 2-5 km deep, shallower than the central troughs. Chaotic terrain is seen in the peripheral troughs near a common contour level of about 4 km on the adjacent plateaus, which supports the idea of release of water under artesian pressure from confined aquifers. The layered deposits in the peripheral troughs may have formed in isolated depressions that harbored lakes and predated the formation of the deep outflow channels. (If these layered deposits are of volcanic origin, they may have been emplaced beneath ice in the manner of table mountains.) Areal and volumetric computations show that erosion widened the troughs by about one-third and that deposits occupy one-sixth of the interior space. Even though the volume eroded is larger than the volume deposited, topographic and geologic considerations imply that material eroded from trough walls was probably part of the interior layered deposits but not their sole source. Additional material may have come from subterranean piping, from reworking of local disintegration products on the floors, such as chaotic materials, or from eolian influx. But overall it is likely that the additional material is volcanic and that it forms mostly the upper, more diversely bedded layers of the interior deposits.

Evidence for a Slow Spreading Ocean Ridge in the Southern Rockall Trough From Satellite Gravity Inversion and Seismic Data

NASA Astrophysics Data System (ADS)

Chappell, A. R.; Kusznir, N. J.

2005-12-01

The southern Rockall Trough, located to the west of Ireland and the UK in the NE Atlantic, has been interpreted as both a Mesozoic intra-continental rift basin (O'Reilly 1995) and a mid Cretaceous ocean basin (e.g. Roberts et al. 1980). The continental rift hypothesis (O'Reilly 1995) requires differential stretching of the upper and lower crust and syn-tectonic cooling to mechanically explain the formation of 5-6km thick continental crust and allow serpentinisation of the upper mantle. In this model serpentinisation of the upper mantle is needed to explain low upper mantle seismic velocities. The serpentinisation has also been required to fit gravity modelling of seismic transects to the observed gravity (e.g. Shannon 1999). We use satellite gravity inversion to map Moho depth and crustal thickness (Chappell & Kusznir 2005) for the Rockall Trough area. The satellite gravity inversion is a 3D spectral method incorporating a correction for the residual lithosphere thermal gravity anomaly present in continental rifted margin lithosphere and oceanic lithosphere. The gravity inversion predicts Moho depth and geometry in agreement with wide-angle seismic estimates without invoking the extensive serpentinisation of the upper-mantle needed by the intra-continental rift hypothesis (O'Reilly 1995). Recent seismic modelling (Morewood 2005) suggests that the thin crust in the southern Rockall Trough does not have the seismic layering associated with oceanic crust formed at intermediate or fast spreading rates. Also, wide-angle seismic data shows low upper mantle seismic velocities are present and spatially associated with the thin 5-6km crust (Shannon 1999). These observations are consistent with models and observations of oceanic crust formed at slow spreading ocean ridges (Cannat 1996, Jokat 2003). Such models are based on a proportion of melt being retained in the upper mantle, producing low seismic velocities, and a reduced supply of melt to the crust, resulting in thin seismic crust with some serpentinised mantle material included. We propose that the southern Rockall Trough was formed by continental break-up and a period of slow mid Cretaceous sea floor spreading rather than as an intra- continental rift basin. This work forms part of the NERC Margins iSIMM project. iSIMM investigators are from Liverpool and Cambridge Universities, Badley Geoscience & Schlumberger Cambridge Research supported by the NERC, the DTI, Agip UK, BP, Amerada Hess Ltd, Anadarko, Conoco-Phillips, Shell, Statoil and WesternGeco. The iSIMM team comprises NJ Kusznir, RS White, AM Roberts, PAF Christie, AR Chappell, J Eccles, RJ Fletcher, D Healy, N Hurst, ZC Lunnon, CJ Parkin, AW Roberts, LK Smith, VJ Tymms & R Spitzer.

Punctuated sediment discharge during early Pliocene birth of the Colorado River: Evidence from regional stratigraphy, sedimentology, and paleontology

USGS Publications Warehouse

Dorsey, Rebecca J.; O’Connell, Brennan; McDougall-Reid, Kristin; Homan, Mindy B.

2018-01-01

The Colorado River in the southwestern U.S. provides an excellent natural laboratory for studying the origins of a continent-scale river system, because deposits that formed prior to and during river initiation are well exposed in the lower river valley and nearby basinal sink. This paper presents a synthesis of regional stratigraphy, sedimentology, and micropaleontology from the southern Bouse Formation and similar-age deposits in the western Salton Trough, which we use to interpret processes that controlled the birth and early evolution of the Colorado River. The southern Bouse Formation is divided into three laterally persistent members: basal carbonate, siliciclastic, and upper bioclastic members. Basal carbonate accumulated in a tide-dominated marine embayment during a rise of relative sea level between ~ 6.3 and 5.4 Ma, prior to arrival of the Colorado River. The transition to green claystone records initial rapid influx of river water and its distal clay wash load into the subtidal marine embayment at ~ 5.4–5.3 Ma. This was followed by rapid southward progradation of the Colorado River delta, establishment of the earliest through-flowing river, and deposition of river-derived turbidites in the western Salton Trough (Wind Caves paleocanyon) between ~ 5.3 and 5.1 Ma. Early delta progradation was followed by regional shut-down of river sand output between ~ 5.1 and 4.8 Ma that resulted in deposition of marine clay in the Salton Trough, retreat of the delta, and re-flooding of the lower river valley by shallow marine water that deposited the Bouse upper bioclastic member. Resumption of sediment discharge at ~ 4.8 Ma drove massive progradation of fluvial-deltaic deposits back down the river valley into the northern Gulf and Salton Trough.These results provide evidence for a discontinuous, start-stop-start history of sand output during initiation of the Colorado River that is not predicted by existing models for this system. The underlying controls on punctuated sediment discharge are assessed by comparing the depositional chronology to the record of global sea-level change. The lower Colorado River Valley and Salton Trough experienced marine transgression during a gradual fall in global sea level between ~ 6.3 and 5.5 Ma, implicating tectonic subsidence as the main driver of latest Miocene relative sea-level rise. A major fall of global sea level at 5.3 Ma outpaced subsidence and drove regional delta progradation, earliest flushing of Colorado River sand into the northern Gulf of California, and erosion of Bouse basal carbonate and siliciclastic members. The lower Colorado River valley was re-flooded by shallow marine waters during smaller changes in global sea level ~ 5.1–4.8 Ma, after the river first ran through it, which requires a mechanism to stop delivery of sand to the lower river valley. We propose that tectonically controlled subsidence along the lower Colorado River, upstream of the southern Bouse study area, temporarily trapped sediment and stopped delivery of sand to the lower river valley and northern Gulf of California for ~ 200–300 kyr. Massive progradation of the fluvial-deltaic system back down the river valley into the Salton Trough starting ~ 4.8–4.5 Ma apparently was driven by a huge increase in sediment discharge that overwhelmed the sediment-storage capacity of sub-basins along the lower river corridor and established the fully integrated river channel network.

The Edge

NASA Technical Reports Server (NTRS)

2006-01-01

6 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the edge (running diagonally from the lower left to the upper right) of a trough, which is part of a large pit crater complex in Noachis Terra. This type of trough forms through the collapse of surface materials into the subsurface, and often begins as a series of individual pit craters. Over time, continued collapse increases the diameter of individual pits until finally, adjacent pits merge to form a trough such as the one captured in this image. The deep shadowed area is caused in part by an overhang; layered rock beneath this overhang is less resistant to erosion, and thus has retreated tens of meters backward, beneath the overhang. A person could walk up inside this 'cave' formed by the overhanging layered material.

Location near: 47.0oS, 355.7oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

Palynostratigraphy of the Upper Cretaceous and Paleogene Deposits in the South of Western Siberia by Example of Russkaya Polyana Boreholes, Omsk Trough

NASA Astrophysics Data System (ADS)

Lebedeva, N. K.; Kuz'mina, O. B.

2018-01-01

The detailed study of Boreholes 8, 10, and 2 in the Russkaya Polyana district (Omsk Trough) made it possible to reveal the complex structure of the Upper Cretaceous sediments formed in unstable conditions of the marginal part of the Western Siberian basin. The Pokur, Kuznetsovo, Ipatovo, Slavgorod, and Gan'kino formations were subjected to palynological analysis and substantiation of their Late Cretaceous age. Eight biostratigraphic units with dinocysts and five units with spores and pollen from the Albian to the Maastrichtian were identified. The joint application of biostratigraphic and magnetostratigraphic methods made it possible to reveal the stratigraphic breaks in the studied sedimentary stratum and to estimate their scope. The age of the Lower Lyulinvor Subformation was specified in the marginal part of the Omsk Trough. The ingression traces of the Western Siberian basin in the Albian were found for the first time in the considered region.

Geologic evolution of the Kastel trough and its implications on the Adiyaman oil fields, SE Turkey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coskun, Bu.

1990-05-01

Oil field developments of the Adiyaman area one of the main oil producing zones in southeast Turkey, have been highly influenced by geologic evolution of the Kastel trough which is situated in front of the suture zone between the Arabian and Anatolian plates. The Upper Cretaceous movements created many paleostructural trends in the Kastel trough where important dolomitic and porous reservoirs exist. The most important tectonic event, which appeared during the Upper Cretaceous movements, is the accumulation of the Kocali-Karadut ophiolitic complex, advancing from the north to the south in the Kastel trough, where heavy materials caused formation of amore » structural model favoring generation and migration and entrapment of oil in the reservoir rocks. Due to the presence of the Kocali-Karadut complex in the Kastel trough the following zones have been distinguished. (1) North Uplift Area. Situated under the allochthonous units, many thrust and reverse faults characterize this zone. The presence of paleohighs, where primary dolomites develop, allows the appearance of some oil fields in the region. This is the main future exploration zone in southeast Turkey. (2) Accumulation Area. Advancing from the north to the south, the allochthonous Kocali-Karadut complex filled the Kastel trough creating a deep graben whose flanks present generally normal faults. (3) Structural Belt. Important paleohighs constitute an exploration trend in this zone where dolomitic and porous carbonates contain actual oil fields. (4) South Accumulation Area. Distant from the Arabian-Anatolian suture zone, regional tectonics and sedimentology show this zone remained deeply buried during geologic time; good source rocks were deposited during the Cretaceous. (5) South Uplift Area. This area corresponds to the northern flank of the huge regional Mardin high in southeast Turkey where new oil fields have been discovered.« less

Movement of fluids in the Nankai Trough area: Insights from 129I and halogen distributions along the IODP NanTroSEIZE transect

NASA Astrophysics Data System (ADS)

Tomaru, Hitoshi; Fehn, Udo

2015-01-01

Halogen concentrations and 129I/I ratios were determined in pore waters from the Nankai Trough subduction system, collected during IODP Expeditions 315, 316, 322, and 333 along the NanTroSEIZE transect. The transect allowed the first direct comparison of iodine results across an active subduction system, from subducting oceanic sediments to the accretionary prism, and the overlying forearc basin. In contrast to the other halogens (Cl and Br) iodine concentrations show large variations within and among the cores at all sites landward of the trough, I concentrations increase rapidly with depth and reach values several orders of magnitude higher than those in seawater, but are only slightly higher than seawater values at the seaward sites. Methane concentrations follow a similar pattern. Host sediments of the fluids are younger than 7 Ma in all the cores, but the ages of iodine in pore waters at the landward sites reach values beyond 30 Ma. In contrast, iodine seaward of the trough is in isotopic equilibrium with the host sediments, resulting in very similar iodine and sediment ages. The distribution of iodine concentrations and ages indicates that iodine at the landward sites has been transported there in aqueous fluids, probably together with methane, from old formations in the upper plate. The specific fluid pathways potentially were influenced by features such as the megasplay fault in the prism or the décollement. The results demonstrate large-scale transport of fluids carrying iodine and other compounds such as methane from old layers in the upper plate to surface locations landward of the Nankai Trough, while separate, but only local hydrologic processes occur in the marine sediments moving toward the trough.

GAS SEAL

DOEpatents

Monson, H.; Hutter, E.

1961-07-11

A seal is described for a cover closing an opening in the top of a pressure vessel that may house a nuclear reactor. The seal comprises a U-shaped trough formed on the pressure vessel around the opening therein, a mass of metal in the trough, and an edge flange on the cover extending loosely into the trough and dipping into the metal mass. The lower portion of the metal mass is kept melted, and the upper portion, solid. The solid pontion of the metal mass prevents pressure surges in the vessel from expelling the liquid portion of the metal mass from the trough; the liquld portion, thus held in place by the solid portion, does not allow gas to go through, and so gas cannot escape through shrinkage holes in the solid portion.

Inhomogeneous Crustal Structure of the Rifting in the Okinawa Trough, a Backarc Basin West of Kyushu, Japan, Deduced from Seismic Reflection and Refraction Data

NASA Astrophysics Data System (ADS)

Nishizawa, A.; Kaneda, K.; Oikawa, M.; Horiuchi, D.; Fujioka, Y.; Okada, C.

2017-12-01

Several depressions found under the thick sediments in the East China Sea shelf have been considered as failed rift basins. Their formation age becomes progressively younger from NW to SE and the youngest rift basin is the Okinawa Trough, an active backarc basin of the Ryukyu (Nansei-Shoto) arc-trench system, to the southwest of Kyusyu, Japan. Its rifting is in progress and related hydrothermal activity is present in the trough. The knowledge of the crustal structure of the trough is fundamental to understand the current active tectonics and predict the future of the trough. We, Japan Coast Guard, have conducted extensive seismic reflection and refraction surveys in the Ryukyu region since 2008 and compiled the seismic structures of the Okinawa Trough. We will show the crustal structures along seven along-trough and ten across-trough seismic survey lines. The P-wave velocity models beneath the Okinawa Trough generally show a thinned continental/island arc crust consisting of upper, middle, and lower crusts. Moho depths below the trough were estimated mainly from Moho reflection (PmP) travel times. The crustal thickness of the trough is thinner than those of the East China Sea shelf and of the Ryukyu Islands. The depth of the Moho below the trough decreases from over 30 km in the north to about 13 km in the south, indicating a difference in degree of the rifting process. The position of the shallowest Moho along the across-trough lines in the northern trough does not necessarily correspond to the center of the trough defined as the deepest water depth, but it corresponds to the transition area between the East China Sea shelf and the Okinawa Trough. An M7.1 earthquake occurred at the transition area on Nov. 14, 2015 (JST) and many aftershocks were observed along the transition. This seismic activity demonstrated that the area is under rifting tectonics in the present.

The Relationship Between Anomalous Presummer Extreme Rainfall Over South China and Synoptic Disturbances

NASA Astrophysics Data System (ADS)

Huang, Ling; Luo, Yali; Zhang, Da-Lin

2018-04-01

A spectral analysis of daily rainfall data has been performed to investigate extreme rainfall events in south China during the presummer rainy seasons between 1998 and 2015 (excluding 1999, 2006, 2011, and 2014). The results reveal a dominant frequency mode at the synoptic scale with pronounced positive rainfall anomalies. By analyzing the synoptic-scale bandpass-filtered anomalous circulations, 24 extreme rainfall episodes (defined as those with a daily rainfall amount in the top 5%) are categorized into "cyclone" (15) and "trough" (8) types, with the remaining events as an "anticyclone" type, according to the primary anomalous weather system contributing to each extreme rainfall episode. The 15 cyclone-type episodes are further separated into (11) lower- and (4) upper-tropospheric migratory anomalies. An analysis of their anomalous fields shows that both types could be traced back to the generation of cyclonic anomalies downstream of the Tibetan Plateau, except for two episodes of lower-tropospheric migratory anomalies originating over the South China Sea. However, a lower-tropospheric cyclonic anomaly appears during all phases in the former type, but only in the wettest phase in the latter type, with its peak disturbance occurring immediately beneath an upper-level warm anomaly. The production of extreme rainfall in the trough-type episodes is closely related to a deep trough anomaly extending from an intense cyclonic anomaly over north China, which in turn could be traced back to a midlatitude Rossby wave train passing by the Tibetan Plateau. The results have important implications for understanding the origin, structure, and evolution of synoptic disturbances associated with the presummer extreme rainfall in south China.

Concurrent immunomodulator therapy is associated with higher adalimumab trough levels during scheduled maintenance therapy.

PubMed

Bond, Ashley; Dodd, Susanna; Fisher, Gareth; Skouras, Thomas; Subramanian, Sreedhar

2017-02-01

Combination therapy with infliximab and immunomodulators is superior to monotherapy, resulting in better outcomes and higher trough levels of infliximab. The role of concurrent immunomodulatory therapy on adalimumab trough levels has not been adequately investigated. We evaluated the impact of concomitant immunomodulation on adalimumab trough levels in patients on scheduled maintenance therapy. We conducted a prospective observational, cross-sectional study of all inflammatory bowel disease patients on maintenance therapy who had adalimumab trough levels measured between January 2013 and January 2016. Drug level and anti-drug antibody measurements were performed on sera using a solid phase assay. Pairwise comparison of means was used to compare trough levels in patients with and without concomitant immune modulator therapy. In total, 79 patients were included. Twenty-three patients (29.1%) were on weekly dosing whereas 56 (70.9%) were on alternate weeks. Median adalimumab trough levels were comparable in patients with and without clinical remission (6.8 μg/ml (IQR 5.6-8.1) versus 6.7 μg/ml (IQR 3.9-8.1), respectively. Patients with an elevated faecal calprotectin >250 μg/g had lower adalimumab trough levels (median 6.7, IQR 3.9-8) compared to patients with faecal calprotectin <250 μg/g (median 7.7, IQR 6.1-8.1) though this did not achieve statistical significance (p = .062). Median adalimumab trough levels among patients on concurrent immunomodulators was 7.2 μg/ml (IQR 5.7-8.1) compared to those not on concurrent immunomodulator, 6.1 μg/ml (IQR 2.7-7.7, p = .0297). Adalimumab trough levels were significantly higher in patients on concurrent immunomodulators during maintenance therapy. There was a trend towards a lower adalimumab trough level in patients with elevated calprotectin.

Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption.

PubMed

Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y

2017-05-01

Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

Currently used dosage regimens of vancomycin fail to achieve therapeutic levels in approximately 40% of intensive care unit patients.

PubMed

Obara, Vitor Yuzo; Zacas, Carolina Petrus; Carrilho, Claudia Maria Dantas de Maio; Delfino, Vinicius Daher Alvares

2016-01-01

This study aimed to assess whether currently used dosages of vancomycin for treatment of serious gram-positive bacterial infections in intensive care unit patients provided initial therapeutic vancomycin trough levels and to examine possible factors associated with the presence of adequate initial vancomycin trough levels in these patients. A prospective descriptive study with convenience sampling was performed. Nursing note and medical record data were collected from September 2013 to July 2014 for patients who met inclusion criteria. Eighty-three patients were included. Initial vancomycin trough levels were obtained immediately before vancomycin fourth dose. Acute kidney injury was defined as an increase of at least 0.3mg/dL in serum creatinine within 48 hours. Considering vancomycin trough levels recommended for serious gram-positive infection treatment (15 - 20µg/mL), patients were categorized as presenting with low, adequate, and high vancomycin trough levels (35 [42.2%], 18 [21.7%], and 30 [36.1%] patients, respectively). Acute kidney injury patients had significantly greater vancomycin trough levels (p = 0.0055, with significance for a trend, p = 0.0023). Surprisingly, more than 40% of the patients did not reach an effective initial vancomycin trough level. Studies on pharmacokinetic and dosage regimens of vancomycin in intensive care unit patients are necessary to circumvent this high proportion of failures to obtain adequate initial vancomycin trough levels. Vancomycin use without trough serum level monitoring in critically ill patients should be discouraged.

Posaconazole plasma concentrations in pediatric patients receiving antifungal prophylaxis during neutropenia.

PubMed

Döring, Michaela; Cabanillas Stanchi, Karin Melanie; Klinker, Hartwig; Eikemeier, Melinda; Feucht, Judith; Blaeschke, Franziska; Schwarze, Carl-Philipp; Ebinger, Martin; Feuchtinger, Tobias; Handgretinger, Rupert; Heinz, Werner J

2017-06-01

Invasive fungal infections are one of the major complications in pediatric patients during prolonged neutropenia after chemotherapy. Evaluation of the efficacy and safety of the triazole posaconazole in these patients is missing. This multicenter survey analyzed trough concentrations of 33 pediatric patients with a median age of 8 years during 108 neutropenic episodes who received prophylactic posaconazole oral suspension. A total of 172 posaconazole trough levels were determined to median 438 ng/ml (range 111-2011 ng/ml; mean 468 ± 244 ng/ml). Age and gender had no influence on posaconazole plasma levels. Posaconazole was not discontinued due to adverse events in any of the patients. Only hepatic parameters significantly increased beyond the upper normal limit to median values of ALT of 87 U/l (P < .0001), and AST of 67 U/l (P < .0001). One patient with a median posaconazole trough concentration of 306 ng/ml experienced an invasive fungal infection. In conclusion, posaconazole was effective, safe and feasible in 33 pediatric patients with neutropenia ≥5 days after chemotherapy. Median posaconazole plasma concentrations were approximately 1.6-fold lower than the recommended plasma level of 700 ng/ml. Larger patient cohorts are needed to evaluate these findings. © The Author 2016. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Waveform anomaly caused by strong attenuation in the crust and upper mantle in the Okinawa Trough region

NASA Astrophysics Data System (ADS)

Padhy, S.; Furumura, T.; Maeda, T.

2017-12-01

The Okinawa Trough is a young continental back-arc basin located behind the Ryukyu subduction zone in southwestern Japan, where the Philippine Sea Plate dives beneath the trough, resulting in localized mantle upwelling and crustal thinning of the overriding Eurasian Plate. The attenuation structure of the plates and surrounding mantle in this region associated with such complex tectonic environment are poorly documented. Here we present seismological evidence for these features based on the high-resolution waveform analyses and 3D finite difference method (FDM) simulation. We analyzed regional broadband waveforms recorded by F-net (NIED) of in-slab events (M>4, H>100 km). Using band-passed (0.5-8 Hz), mean-squared envelopes, we parameterized coda-decay in terms of rise-time (time from P-arrival to maximum amplitude in P-coda), decay-time (time from maximum amplitude to theoretical S-arrival), and energy-ratio defined as the ratio of energy in P-coda to that in direct P wave. The following key features are observed. First, there is a striking difference in S-excitation along paths traversing and not traversing the trough: events from SW Japan not crossing the trough show clear S waves, while those occurring in the trough show very weak S waves at a station close to the volcanic front. Second, some trough events exhibit spindle-shaped seismograms with strong P-coda excitation, obscuring the development of S waves, at back-arc stations; these waveforms are characterized by high decay-time (>10s) and high energy-ratio (>>1.0), suggesting strong forward scattering along ray paths. Third, some trough events show weak S-excitation characterized by low decay-time (<5s) and low energy-ratio (<1.0) at fore-arc stations, suggesting high intrinsic absorption. To investigate the mechanism of the observed anomalies, we will conduct FDM simulation for a suite of models comprising the key subduction features like localized mantle-upwelling and crustal thinning expected in the region. It is expected that simulation results help to resolve rift-induced crust and upper mantle anomalies in the trough showing maximum waveform distortion as we observed in broadband records, and will enhance understanding of tectonic processes related to back-arc rifting in the region.

Convection and Easterly Wave Structure Observed in the Eastern Pacific Warm-Pool during EPIC-2001

NASA Technical Reports Server (NTRS)

Peterson, Walter A.; Cifelli, R.; Boccippio, D.; Rutledge, S. A.; Fairall, C. W.; Arnold, James E. (Technical Monitor)

2002-01-01

During September-October 2001, the East Pacific Investigation of Climate Processes in the Coupled Ocean-Atmosphere System (EPIC-2001) ITCZ field campaign focused on studies of deep convection in the warm-pool region of the East Pacific. In addition to the TAO mooring array, observational platforms deployed during the field phase included the NOAA ship RN Ronald H. Brown, the NSF ship RN Horizon, and the NOAA P-3 and NCAR C-130 aircraft. This study combines C-band Doppler radar, rawinsonde, and surface heat flux data collected aboard the RN Brown to describe ITCZ convective structure and rainfall statistics in the eastern Pacific as a function of 3-5 day easterly wave phase. Three distinct easterly wave passages occurred during EPIC-2001. Wind and thermodynamic data reveal that the wave trough axes exhibited positively correlated U and V winds and a slight westward phase tilt with height. A relatively strong (weak) northeasterly deep tropospheric shear followed the trough (ridge) axis. Temperature and humidity perturbations exhibited mid-to upper level cooling (warming) and drying (moistening) in the northerly (trough and southerly) phase. At low levels warming (cooling) occurred in the northerly (southerly) phase with little change in the relative humidity, though mixed layer mixing ratios were larger during the northerly phase. When composited, radar, sounding, lightning and surface heat flux observations suggest the following systematic behavior as a function of wave phase: approximately zero to one quarter wavelength ahead of (behind) the wave trough in northerly (southerly) flow, larger (smaller) CAPE, lower (higher) CIN, weaker (stronger) tropospheric shear, higher (lower) conditional mean rain rates, higher (lower) lightning flash densities, and more (less) robust convective vertical structure occurred. Latent and sensible heat fluxes reached a minimum in the northerly phase and then increased through the trough, reaching a peak during the ridge phase (leading the peak in CAPE). From a radar echo coverage perspective, larger areas of light rain and slightly larger (10%) area averaged rain rates occurred in the vicinity of, and just behind, the trough axes in southerly flow. Importantly, the transition in convective structure observed across the trough axis when considered with the relatively small change in area mean rain rates suggests the presence of a transition in the vertical structure of diabatic heating across the easterly waves examined. The inferred transition in heating structure is supported by radar diagnosed divergence profiles that exhibit convective (stratiform) characteristics ahead of (behind) the trough.

Optimum employment of satellite indirect soundings as numerical model input

NASA Technical Reports Server (NTRS)

Horn, L. H.; Derber, J. C.; Koehler, T. L.; Schmidt, B. D.

1981-01-01

The characteristics of satellite-derived temperature soundings that would significantly affect their use as input for numerical weather prediction models were examined. Independent evaluations of satellite soundings were emphasized to better define error characteristics. Results of a Nimbus-6 sounding study reveal an underestimation of the strength of synoptic scale troughs and ridges, and associated gradients in isobaric height and temperature fields. The most significant errors occurred near the Earth's surface and the tropopause. Soundings from the TIROS-N and NOAA-6 satellites were also evaluated. Results again showed an underestimation of upper level trough amplitudes leading to weaker thermal gradient depictions in satellite-only fields. These errors show a definite correlation to the synoptic flow patterns. In a satellite-only analysis used to initialize a numerical model forecast, it was found that these synoptically correlated errors were retained in the forecast sequence.

Study on impacts of an exceptionally intense sandstorm upon Gansu region in summer

NASA Astrophysics Data System (ADS)

Wang, Xiwen; Huang, Yuxia; Liu, Zhiguo; Wei, Feng; Zhang, Tiejun

2007-09-01

The Climate features of summer sandstorms show that the season is rich in the disasters for the Gansu region, concentrated mainly in the Minqin, Dingxin and Jinta areas. The synoptic analysis of a rarely observed strong event indicates that in summer such dominant weather systems as the upper-level weak trough, shear line and thermal low are responsible for the sandstorm while in spring the tempest is generally triggered by large-scale systems. The upper-level jet's behaviors are not so manifest before the occurrence of the summertime sandstorm, with the jets suddenly intensified almost concurrently with its occurrence, which is one of the difficult points for forecasting the summer sandstorm. Now for the study we make use of satellite imagery and its sensings-based tracking as a more visualized tool for monitoring the onset, movement and coverage of the disaster.

Punctuated Sediment Discharge during Early Pliocene Birth of the Colorado River: Evidence from Regional Stratigraphy, Sedimentology, and Paleontology

NASA Astrophysics Data System (ADS)

Dorsey, Rebecca J.; O'Connell, Brennan; McDougall, Kristin; Homan, Mindy B.

2018-01-01

The Colorado River in the southwestern U.S. provides an excellent natural laboratory for studying the origins of a continent-scale river system, because deposits that formed prior to and during river initiation are well exposed in the lower river valley and nearby basinal sink. This paper presents a synthesis of regional stratigraphy, sedimentology, and micropaleontology from the southern Bouse Formation and similar-age deposits in the western Salton Trough, which we use to interpret processes that controlled the birth and early evolution of the Colorado River. The southern Bouse Formation is divided into three laterally persistent members: basal carbonate, siliciclastic, and upper bioclastic members. Basal carbonate accumulated in a tide-dominated marine embayment during a rise of relative sea level between 6.3 and 5.4 Ma, prior to arrival of the Colorado River. The transition to green claystone records initial rapid influx of river water and its distal clay wash load into the subtidal marine embayment at 5.4-5.3 Ma. This was followed by rapid southward progradation of the Colorado River delta, establishment of the earliest through-flowing river, and deposition of river-derived turbidites in the western Salton Trough (Wind Caves paleocanyon) between 5.3 and 5.1 Ma. Early delta progradation was followed by regional shut-down of river sand output between 5.1 and 4.8 Ma that resulted in deposition of marine clay in the Salton Trough, retreat of the delta, and re-flooding of the lower river valley by shallow marine water that deposited the Bouse upper bioclastic member. Resumption of sediment discharge at 4.8 Ma drove massive progradation of fluvial-deltaic deposits back down the river valley into the northern Gulf and Salton Trough. These results provide evidence for a discontinuous, start-stop-start history of sand output during initiation of the Colorado River that is not predicted by existing models for this system. The underlying controls on punctuated sediment discharge are assessed by comparing the depositional chronology to the record of global sea-level change. The lower Colorado River Valley and Salton Trough experienced marine transgression during a gradual fall in global sea level between 6.3 and 5.5 Ma, implicating tectonic subsidence as the main driver of latest Miocene relative sea-level rise. A major fall of global sea level at 5.3 Ma outpaced subsidence and drove regional delta progradation, earliest flushing of Colorado River sand into the northern Gulf of California, and erosion of Bouse basal carbonate and siliciclastic members. The lower Colorado River valley was re-flooded by shallow marine waters during smaller changes in global sea level 5.1-4.8 Ma, after the river first ran through it, which requires a mechanism to stop delivery of sand to the lower river valley. We propose that tectonically controlled subsidence along the lower Colorado River, upstream of the southern Bouse study area, temporarily trapped sediment and stopped delivery of sand to the lower river valley and northern Gulf of California for 200-300 kyr. Massive progradation of the fluvial-deltaic system back down the river valley into the Salton Trough starting 4.8-4.5 Ma apparently was driven by a huge increase in sediment discharge that overwhelmed the sediment-storage capacity of sub-basins along the lower river corridor and established the fully integrated river channel network. Accompanies Dorsey et al. "Punctuated sediment discharge during early Pliocene birth of the Colorado River: Evidence from regional stratigraphy, sedimentology, and paleontology". Accompanies Dorsey et al. "Punctuated sediment discharge during early Pliocene birth of the Colorado River: Evidence from regional stratigraphy, sedimentology, and paleontology". Accompanies Dorsey et al. "Punctuated sediment discharge during early Pliocene birth of the Colorado River: Evidence from regional stratigraphy, sedimentology, and paleontology".

Geophysical basin structure of the Cotonou (Dahomey/Benin) basin, West African Gulf of Guinea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babalola, O.O.

1990-05-01

The frontier Cotonou basin (or Dahomey/Benin embayment), situated west of the prolific Niger Delta basin, appears from seismic, gravity, and aeromagnetic interpretation, as a series of grabens and troughs confined on the west and east by the Romanche and the Chain fracture zones, respectively. The Keta trough of the western basin rim was formed by a 2700-m southeasterly downthrow of the Adina fault. This trough is separated by a north-northeasterly fault from the Lome-Anecho gravity high. Eastward, the arcuate Allada-Adjohon trough is abutted on its southern flank by the northwest-trending Nokue-Afowo trough and separated from the northwesterly Ikorodu trough bymore » the 50-km-wide aeromagnetically inferred ro-Otta ridge. The Ikorodu trough is adjoined on the northwest by the Aiyetoro trough and on the southeast by the Yemoja offshore graben trending east northeast as the Seme oil-field structural trend. North of the regional northeasterly axial, gravity positive, structural divide (the continental precursor of the Charcot fracture zone) a series of half-grabens (notably the Aplahoue, Bohicon, and Keiou troughs), normal faulted eastward and downthrown in the west, dominate the landward western rim of the Cotonou basin. Graben-bounding faults control the upper valleys of the basin drainage, converge toward the regional intrabasin structural trend and continue into the Fenyi-koe fault and the Charcot fracture zone. These faults resulted from brittle dextral shear of continental crust oblique to local, preexisting north-northeast structural trends. In the eastern basin rim, preexisting north-northwest structural trends influenced the shearing stress regime to generate small, shallow, structurally bounded, east-northeast- and north-northwest trending grabens.« less

Dawn LAMO Image 62

NASA Image and Video Library

2016-04-07

Tupo Crater, named for the Polynesian god of turmeric, is shown at upper left in this view of Ceres from NASA Dawn spacecraft. Just below the crater, a line of narrow troughs parallels the rim of Tupo.

Structures and Evolutions of Explosive Cyclones over the Northwestern and Northeastern Pacific

NASA Astrophysics Data System (ADS)

Zhang, Shuqin; Fu, Gang

2018-06-01

In this study, the structures and evolutions of moderate (MO) explosive cyclones (ECs) over the Northwestern Pacific (NWP) and Northeastern Pacific (NEP) are investigated and compared using composite analysis with cyclone-relative coordinates. Final Operational Global Analysis data gathered during the cold seasons (October-April) of the 15 years from 2000 to 2015 are used. The results indicate that MO NWP ECs have strong baroclinicity and abundant latent heat release at low levels and strong upper-level forcing, which favors explosive cyclogenesis. The rapid development of MO NEP ECs results from their interaction with a northern cyclone and a large middle-level advection of cyclonic vorticity. The structural differences between MO NWP ECs and MO NEP ECs are significant. This results from their specific large-scale atmospheric and oceanic environments. MO NWP ECs usually develop rapidly in the east and southeast of the Japan Islands; the intrusion of cold dry air from the East Asian continent leads to strong baroclinicity, and the Kuroshio/Kuroshio Extension provides abundant latent heat release at low levels. The East Asian subtropical westerly jet stream supplies strong upper-level forcing. While MO NEP ECs mainly occur over the NEP, the low-level baroclinicity, upper-level jet stream, and warm ocean currents are relatively weaker. The merged cyclone associated with a strong middle-level trough transports large cyclonic vorticity to MO NEP ECs, which favors their rapid development.

Tracking Boulders

NASA Technical Reports Server (NTRS)

2006-01-01

13 March 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a trough in the Sirenum Fossae region. On the floor and walls of the trough, large -- truck- to house-sized -- boulders are observed at rest. However, there is evidence in this image for the potential for mobility. In the central portion of the south (bottom) wall, a faint line of depressions extends from near the middle of the wall, down to the rippled trough floor, ending very near one of the many boulders in the area. This line of depressions is a boulder track; it indicates the path followed by the boulder as it trundled downslope and eventually came to rest on the trough floor. Because it is on Mars, even when the boulder is sitting still, this once-rolling stone gathers no moss.

Location near: 29.4oS, 146.6oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

Effect of the El Nino/southern oscillation on Gulf of Mexico, winter, frontal-wave cyclones: 1960-1989. (Volumes I and II)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manty, R.E.

Seasonal counts of frontal-wave cyclones forming over the Gulf of Mexico and its coastal plain show more storms in the five El Nino winters and fewer storms in the eight La Nina winters, from 1960 to 1989, significant at the .01 level by a rank sum test. This is corroborated by two results. First, during the same period, the frequency of frontal-overrunning weather conditions in the region, indicative of storms, was higher in El Nino winters and lower in La Nina winters. Second, 100 years of precipitation and temperature records show wetter, cooler El Nino winters and drier, warmer Lamore » Nina winters at gulf-region land stations and climatic divisions. A threefold explanation, based on National Meteorological Center, upper-air data, is offered for the greater frequency of gulf-region cyclogenesis during El Nino winters between 1960 and 1989. (1) The winter, mean, 250-mb jet over the southern US is intensified by 5 to 10 ms[sup [minus]1] and displaced southward between 110[degrees] and 75[degrees]W by an average of 200 to 285 km during the five El Nino winters. This implies stronger and more frequent episodes of jet-associated, upper-level troughing and divergence over the region, reinforcing surface, frontal-wave cyclones. (2) In the five El Nino winters between 1963 and 1989, seasonal average heights and temperatures of the 850-, 700-, 500-, and 200-mb surfaces are lower over the region than they are in non-El Nino winters. This implies more-common presence of cold, low-pressure troughs at upper levels, reinforcing surface cyclones. (3) A 10[degrees] eastward shift, at sea level, of the western edge of the Bermuda high during the eight El Nino winters, changes normally due-easterly trades in the northwestern Caribbean Sea to slightly south of east, allowing greater advection of moisture and heat into the gulf from the tropics, preconditioning the area for development of surface cyclones. Only winter season shows all three conditions and an increase in cyclogenesis.« less

Three-dimensional circulation structures leading to heavy summer rainfall over central North China

NASA Astrophysics Data System (ADS)

Sun, Wei; Yu, Rucong; Li, Jian; Yuan, Weihua

2016-04-01

Using daily and hourly rain gauge records and Japanese 25 year reanalysis data over 30 years, this work reveals two major circulation structures leading to heavy summer rainfall events in central North China (CNC), and further analyzes the effects of the circulations on these rainfall events. One circulation structure has an extensive upper tropospheric warm anomaly (UTWA) covering North China (NC). By strengthening the upper anticyclonic anomaly and lower southerly flows around NC, the UTWA plays a positive role in forming upper level divergence and lower level moisture convergence. As a result, the warm anomalous circulation has a solid relationship with large-scale, long-duration rainfall events with a diurnal peak around midnight to early morning. The other circulation structure has an upper tropospheric cold anomaly (UTCA) located in the upper stream of NC. Contributed to by the UTCA, a cold trough appears in the upper stream of NC and an unstable configuration with upper (lower) cold (warm) anomalies forms around CNC. Consequently, CNC is covered by strong instability and high convective energy, and the cold anomalous circulation is closely connected with local, short-duration rainfall events concentrated from late afternoon to early nighttime. The close connections between circulation structures and typical rainfall events are confirmed by two independent converse analysis processes: from circulations to rainfall characteristics, and from typical rainfall events to circulations. The results presented in this work indicate that the upper tropospheric temperature has significant influences on heavy rainfall, and thus more attention should be paid to the upper tropospheric temperature in future analyses.

Method and apparatus for reducing cleaning blade wear

DOEpatents

Grannes, Steven G.; Rhoades, Charles A.; Hebbie, Terry L.

1992-01-01

An improved cleaning blade construction (10) for eliminating erosion troughs (6) in the upper surface (15) of a cleaning blade member (14) by introducing pressurized fluid through a pressure manifold chamber (16) formed in the upper surface (15) of the cleaning blade member (14). The pressurized fluid will prevent carryback material (7) from passing through a wear groove (6) formed in the cleaning blade member.

Upper mantle electrical resistivity structure beneath back-arc spreading centers

NASA Astrophysics Data System (ADS)

Seama, N.; Shibata, Y.; Kimura, M.; Shindo, H.; Matsuno, T.; Nogi, Y.; Okino, K.

2011-12-01

We compare four electrical resistivity structure images of the upper mantle across back-arc spreading centers (Mariana Trough at 18 N and 13 N, and the Eastern Lau at 19.7 S and 21.3 S) to provide geophysical constraints on issues of mantle dynamics beneath the back-arc spreading system related to the subducting slab. The central Mariana Trough at 18 N has the full spreading rate of 25 km/Myr, and shows characteristic slow-spreading features; existence of median valley neovolcanic zone and "Bull's eyes" mantle Bouguer anomaly (MBA) along the axes. On the other hand, the southern Mariana Trough at 13 N shows an EPR type axial relief in morphology and lower MBA than that in the central Mariana Trough (Kitada et al., 2006), suggesting abundance of magma supply, even though the full spreading rate is 35 km/Myr that is categorized as a slow spreading ridge. At the Eastern Lau spreading center, crustal thickness and morphology vary systematically with arc proximity and shows the opposed trends against spreading rate: The full spreading rate increases from 65 km/Myr at 21.3 S to 85 km/Myr at 19.7 S, while the crustal thicknesses decrease together with morphology transitions from shallow peaked volcanic highs to a deeper flat axis (Martinez et al., 2006). Matsuno et al. (2010) provides a resistivity structure image of the upper mantle across the central Mariana subduction system, which contains several key features: There is an uppermost resistive layer with a thickness of 80-100 km beneath the central Mariana Trough, suggesting dry residual from the plate accretion process. But there is no evidence for a conductive feature beneath the back-arc spreading center at 18 N, and this feature is clearly independent from the conductive region beneath the volcanic arc below 60 km depth that reflects melting and hydration driven by water release from the subducting slab. The resultant upper mantle resistivity structure well support that the melt supply is not abundant, resulting in characteristic slow-spreading features at the surface. We have conducted marine magnetotelluric (MT) surveys at the southern Mariana in 2010 and at the Eastern Lau in 2009-2010. We obtained 10 ocean bottom electro-magnetometer (OBEM) data from a 130 km length MT transect across the southern Mariana spreading axis at 13 N, while we obtained 2 OBEM data and 11 ocean bottom magnetometer data from two 160 km length MT transects across the Eastern Lau spreading axes at 19.7 S and 21.3 S. After calculation of MT response functions and their correction for topographic distortion, two-dimensional electrical resistivity structures will be derived using an inversion algorithm. At this meeting, first we will show the resistivity structure images of the upper mantle beneath these spreading axes. Then, these structure images will be compared to identify differences in the mantle dynamics and the melt supply beneath the back-arc spreading system related to the subducting slab.

Multiscale Aspects of the Storm Producing the June 2013 Flooding in Uttarakhand, India

DOE Office of Scientific and Technical Information (OSTI.GOV)

Houze, R. A.; McMurdie, L. A.; Rasmussen, K. L.

Conditions producing disastrous flooding in Uttarakhand, India, in June 2013 differed from conditions that produced other notorious floods in the Himalayan region in recent years. During the week preceding the Uttarakhand flood, deep convection moistened the mountainsides, making them vulnerable to flooding. However, the precipitation producing the flood was not associated with a deep convective event. Rather, an eastward-propagating upper-level trough in the westerlies extended abnormally far southward, with the jet reaching the Himalayas. The south end of the trough merged with a monsoon low moving westward across India. The merged system produced persistent moist low-level flow oriented normal tomore » the Himalayas that advected large amounts of water vapor into the Uttarakhand region. The flow was moist neutral when it passed over the Himalayan barrier, and orographic lifting produced heavy continuous rain over the region for 2–3 days. The precipitation was largely stratiform in nature although embedded convection of moderate depth occurred along the foothills, where some mild instability was being released. The Uttarakhand flood had characteristics in common with major 2013 floods in the Rocky Mountains in Colorado and Alberta, Canada.« less

Dynamics of water-table fluctuations in an upland between two prairie-pothole wetlands in North Dakota

USGS Publications Warehouse

Rosenberry, Donald O.; Winter, Thomas C.

1997-01-01

Data from a string of instrumented wells located on an upland of 55 m width between two wetlands in central North Dakota, USA, indicated frequent changes in water-table configuration following wet and dry periods during 5 years of investigation. A seasonal wetland is situated about 1.5 m higher than a nearby semipermanent wetland, suggesting an average ground water-table gradient of 0.02. However, water had the potential to flow as ground water from the upper to the lower wetland during only a few instances. A water-table trough adjacent to the lower semipermanent wetland was the most common water-table configuration during the first 4 years of the study, but it is likely that severe drought during those years contributed to the longevity and extent of the water-table trough. Water-table mounds that formed in response to rainfall events caused reversals of direction of flow that frequently modified the more dominant water-table trough during the severe drought. Rapid and large water-table rise to near land surface in response to intense rainfall was aided by the thick capillary fringe. One of the wettest summers on record ended the severe drought during the last year of the study, and caused a larger-scale water-table mound to form between the two wetlands. The mound was short in duration because it was overwhelmed by rising stage of the higher seasonal wetland which spilled into the lower wetland. Evapotranspiration was responsible for generating the water-table trough that formed between the two wetlands. Estimation of evapotranspiration based on diurnal fluctuations in wells yielded rates that averaged 3–5 mm day−1. On many occasions water levels in wells closer to the semipermanent wetland indicated a direction of flow that was different from the direction indicated by water levels in wells farther from the wetland. Misinterpretation of direction and magnitude of gradients between ground water and wetlands could result from poorly placed or too few observation wells, and also from infrequent measurement of water levels in wells.

Early vedolizumab trough levels predict mucosal healing in inflammatory bowel disease: a multicentre prospective observational study.

PubMed

Yacoub, W; Williet, N; Pouillon, L; Di-Bernado, T; De Carvalho Bittencourt, M; Nancey, S; Lopez, A; Paul, S; Zallot, C; Roblin, X; Peyrin-Biroulet, L

2018-04-01

The correlation between vedolizumab trough levels during induction therapy and mucosal healing remains unknown. To compare early vedolizumab trough levels in patients with and without mucosal healing within the first year after treatment initiation. We prospectively collected vedolizumab trough levels in all inflammatory bowel disease patients at weeks 2, 6 and 14 of vedolizumab treatment in three French referral centres between 1 June 2014 and 31 March 2017. Results of every patient that underwent mucosal assessment by magnetic resonance imaging and/or endoscopy in the first year after treatment initiation were analysed. Median vedolizumab trough levels in the overall population (n = 82) were 27 μg/mL (interquartile range, IQR 21.2-33.8 μg/mL) at week 2, 23 μg/mL (IQR 15-34.5 μg/mL) at week 6 and 10.7 μg/mL (IQR 4.6-20.4 μg/mL) at week 14. Only median vedolizumab trough levels at week 6 differed between patients with and without mucosal healing within the first year after treatment initiation (26.8 vs 15.1 μg/mL, P = 0.035). A cut-off trough level of 18 μg/mL at week 6 predicted mucosal healing within the first year after the start of vedolizumab with an area under the receiver operating curve of 0.735 (95% confidence interval 0.531-0.939). A vedolizumab trough level above 18 μg/mL at week 6 was the only independent variable associated with mucosal healing within the first year of treatment (odds ratio 15.7, 95% confidence interval 2.4-173.0, P = 0.01). Early therapeutic drug monitoring might improve timely detection of vedolizumab-treated patients in need for an intensified dosing regimen. © 2018 John Wiley & Sons Ltd.

Multilevel groundwater monitoring of hydraulic head and temperature in the eastern Snake River Plain aquifer, Idaho National Laboratory, Idaho, 2011-13

USGS Publications Warehouse

Twining, Brian V.; Fisher, Jason C.

2015-01-01

Normalized mean head values were analyzed for all 11 multilevel monitoring wells for the period of record (2007–13). The mean head values suggest a moderately positive correlation among all boreholes and generally reflect regional fluctuations in water levels in response to seasonal climatic changes. Boreholes within volcanic rift zones and near the southern boundary (USGS 103, USGS 105, USGS 108, USGS 132, USGS 135, USGS 137A) display a temporal correlation that is strongly positive. Boreholes in the Big Lost Trough display some variations in temporal correlations that may result from proximity to the mountain front to the northwest and episodic flow in the Big Lost River drainage system. For example, during June 2012, boreholes MIDDLE 2050A and MIDDLE 2051 showed head buildup within the upper zones when compared to the June 2010 profile event, which correlates to years when surface water was reported for the Big Lost River several months preceding the measurement period. With the exception of borehole USGS 134, temporal correlation between MLMS wells completed within the Big Lost Trough is generally positive. Temporal correlation for borehole USGS 134 shows the least agreement with other MLMS boreholes located within the Big Lost Trough; however, borehole USGS 134 is close to the mountain front where tributary valley subsurface inflow is suspected.

An extreme anomaly in stratospheric ozone over Europe in 1940-1942

NASA Astrophysics Data System (ADS)

Brönnimann, S.; Luterbacher, J.; Staehelin, J.; Svendby, T. M.

2004-04-01

Reevaluated historical total ozone data reveal extraordinarily high values over several European sites in 1940-1942, concurrent with extreme climatic anomalies at the Earth's surface. Using historical radiosonde data, reconstructed upper-level fields, and total ozone data from Arosa (Switzerland), Dombås, and Tromsø (Norway), this unusual case of stratosphere-troposphere coupling is analyzed. At Arosa, numerous strong total ozone peaks in all seasons were due to unusually frequent upper troughs over central Europe and related ozone redistribution in the lower stratosphere. At the Norwegian sites, high winter total ozone was most likely caused by major stratospheric warmings in Jan./Feb. 1940, Feb./Mar. 1941, and Feb. 1942. Results demonstrate that the dynamically driven interannual variability of total ozone can be much larger than that estimated based on the past 25-40 years.

Impact of structural and autocyclic basin-floor topography on the depositional evolution of the deep-water Valparaiso forearc basin, central Chile

USGS Publications Warehouse

Laursen, J.; Normark, W.R.

2003-01-01

The Valparaiso Basin constitutes a unique and prominent deep-water forearc basin underlying a 40-km by 60-km mid-slope terrace at 2.5-km water depth on the central Chile margin. Seismic-reflection data, collected as part of the CONDOR investigation, image a 3-3.5-km thick sediment succession that fills a smoothly sagged, margin-parallel, elongated trough at the base of the upper slope. In response to underthrusting of the Juan Ferna??ndez Ridge on the Nazca plate, the basin fill is increasingly deformed in the seaward direction above seaward-vergent outer forearc compressional highs. Syn-depositional growth of a large, margin-parallel monoclinal high in conjunction with sagging of the inner trough of the basin created stratal geometries similar to those observed in forearc basins bordered by large accretionary prisms. Margin-parallel compressional ridges diverted turbidity currents along the basin axis and exerted a direct control on sediment depositional processes. As structural depressions became buried, transverse input from point sources on the adjacent upper slope formed complex fan systems with sediment waves characterising the overbank environment, common on many Pleistocene turbidite systems. Mass failure as a result of local topographic inversion formed a prominent mass-flow deposit, and ultimately resulted in canyon formation and hence a new focused point source feeding the basin. The Valparaiso Basin is presently filled to the spill point of the outer forearc highs, causing headward erosion of incipient canyons into the basin fill and allowing bypass of sediment to the Chile Trench. Age estimates that are constrained by subduction-related syn-depositional deformation of the upper 700-800m of the basin fill suggest that glacio-eustatic sea-level lowstands, in conjunction with accelerated denudation rates, within the past 350 ka may have contributed to the increase in simultaneously active point sources along the upper slope as well as an increased complexity of proximal depositional facies.

Analysis of the convective characteristics during the mutual evolution of an inverted trough/low vortex and its induced rainstorm over the northeastern Sichuan basin, China

NASA Astrophysics Data System (ADS)

Chen, Yongren; Li, Yueqing; Qi, Dongmei

2018-04-01

Based on a variety of ground-based and satellite-derived observational data, we studied a flood-rainstorm event that occurred over northeastern Sichuan, China, from the 8th to the 14th of September 2014. Four periods of mesoscale convective system (MCS) activity were found during a mutual evolution process of an 850-hPa basin inverted trough (BIT) and 850-hPa basin low vortex (BLV). Among them, the first three periods occurred in an alternating evolution of the BIT and BLV (called the first stage), and then, the fourth period was stimulated by continuous activity of the BLV (called the second stage). During the first stage, MCSs enhanced (weakened) under the situation of the BIT (BLV), and then during the second stage MCSs developed to their strongest levels. Further analysis of the reasons behind the enhancement and weakening of MCSs revealed an obvious characteristic of upper level (lower level) positive (negative) divergence in the BIT situation of the first stage and BLV situation of the second stage. By comparison, under the BLV situation of the first stage, the vertical helicity was larger in the upward airflow of the zonal circulation, and the direction of the wet Q-vector was toward the ascending airflow in the vertical direction. In the horizontal direction, the negative divergence of the wet Q-vector corresponded to the position of water vapor flux convergence. In addition, in the early development of convection, sounding data showed a humidity profile of dry upper and wet lower levels, as well as a larger value of convective available potential energy, which triggered convective activity under the favorable dynamic conditions of atmosphere. When the above characteristics weakened, the convective activity also weakened. Therefore, the formation of multiple convective systems was closely related to the adjustment in atmospheric conditions around the BIT and BLV.

Laboratory measurement of apixaban using anti-factor Xa assays in acute ischemic stroke patients with non-valvular atrial fibrillation.

PubMed

Shin, Hyoshim; Cho, Min-Chul; Kim, Rock Bum; Kim, Chang-Hun; Choi, Nack-Cheon; Kim, Soo-Kyung; Koh, Eun-Ha

2018-02-01

Apixaban is effective and safe for preventing stroke, and its usage has increased exponentially in recent years. However, data concerning the therapeutic range of apixaban is limited. This study determined the trough and peak levels of apixaban-specific anti-factor Xa activity (AFXaA) in acute ischemic stroke patients with non-valvular atrial fibrillation (NVAF) in Korea. The study included 85 patients who received apixaban. Blood samples were taken to measure the trough and peak levels of AFXaA using a chromogenic anti-factor assay, as well as prothrombin time (PT) and activated partial thromboplastin time (aPTT). We also reviewed complications such as major bleeding of patients treated with apixaban. In patients given a 5.0-mg apixaban dose, the median trough and peak levels of AFXaA were 104.5 and 202.0 ng/mL. In patients given a 2.5-mg apixaban dose, the median trough and peak AFXaA levels were 76.0 and 151.0 ng/mL. The PT showed a positive correlation with increased AFXaA activity at both levels (Trough R = 0.486, Peak R = 0.592), but the aPTT had no relationship with AFXaA activity at both levels (Trough R = 0.181, Peak R = 0.129). Two cases with intracranial bleeding belonged to the highest AFXaA quartile (Trough, p = 0.176; Peak, p = 0.053). In conclusion, we determined the trough and peak levels of AFXaA in patients with NVAF while being treated with the apixaban in Korea. Our results could be used as a starting point when setting the reference ranges for laboratories using anti-Xa assay. Large-scale studies are needed to establish the reference range for AFXaA in patients with NVAF.

A kinematic model for the late Cenozoic development of southern California crust and upper mantle

NASA Technical Reports Server (NTRS)

Humphreys, Eugene D.; Hager, Bradford H.

1990-01-01

A model is developed for the young and ongoing kinematic deformation of the southern California crust and upper mantle. The kinematic model qualitatively explains both the overall seismic structure of the upper mantle and much of the known geological history of the late Cenozoic as consequences of ongoing convection beneath southern California. In this model, the high-velocity upper-mantle anomaly of the Transverse ranges is created through the convergence and sinking of the entire thickness of subcrustal lihtosphere, and the low-velocity upper-mantle anomaly beneath the Salton Trough region is attributed to high temperatures and 1-4 percent partial melt related to adiabatic decompression during mantle upwelling.

Sensitivity analysis on the effect of key parameters on the performance of parabolic trough solar collectors

NASA Astrophysics Data System (ADS)

Muhlen, Luis S. W.; Najafi, Behzad; Rinaldi, Fabio; Marchesi, Renzo

2014-04-01

Solar troughs are amongst the most commonly used technologies for collecting solar thermal energy and any attempt to increase the performance of these systems is welcomed. In the present study a parabolic solar trough is simulated using a one dimensional finite element model in which the energy balances for the fluid, the absorber and the envelope in each element are performed. The developed model is then validated using the available experimental data . A sensitivity analysis is performed in the next step in order to study the effect of changing the type of the working fluid and the corresponding Reynolds number on the overall performance of the system. The potential improvement due to the addition of a shield on the upper half of the annulus and enhancing the convection coefficient of the heat transfer fluid is also studied.

Slide Conveying of Granular Materials-Thinking Out of the Glovebox

NASA Technical Reports Server (NTRS)

Goddard, J. D.; Didwania, A. K.; Nott, P. R.

2000-01-01

The vibratory conveyor, routinely employed for normal-gravity transport of granular materials, usually consists of a continuous open trough vibrated sinusoidally to induce axial movement of a granular material. Motivated in part by a hypothetical application in zero gravity, we propose a novel modification of the vibratory conveyor based on a closed 2d trough operating in a "slide-conveying" mode, with the granular mass remaining permanently in contact with the trough walls. We present a detailed analysis of the mechanics of transport, based on a rigid-slab model for the granular mass with frictional (Coulomb) slip at the upper and lower walls. The form of the vibration cycle plays a crucial role, and the optimal conveying cycle is not the commonly assumed rectilinear sinusoidal motion. The conveying efficiency for the novel slide conveyor will be presented for several simple vibration cycles, including one believed to represent the theoretical optimum.

Prediction of Vancomycin Dose for Recommended Trough Concentrations in Pediatric Patients With Cystic Fibrosis.

PubMed

Amin, Raid W; Guttmann, Rodney P; Harris, Quianna R; Thomas, Janesha W

2018-05-01

Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus. The present study sought to develop a model based on empirical evidence of optimal vancomycin dose as judged by clinical observations that could accelerate the achievement of desired trough level in children with cystic fibrosis. Transformations of dose and trough were used to arrive at regression models with excellent fit for dose based on weight or age for a target trough. Results of this study indicate that the 2 proposed regression models are robust to changes in age or weight, suggesting that the daily dose on a per-kilogram basis is determined primarily by the desired trough level. The results show that to obtain a vancomycin trough level of 20 μg/mL, a dose of 80 mg/kg/day is needed. This analysis should improve the efficiency of vancomycin usage by reducing the number of titration steps, resulting in improved patient outcome and experience. © 2018, The American College of Clinical Pharmacology.

Simulations and Visualizations of Hurricane Sandy (2012) as Revealed by the NASA CAMVis

NASA Technical Reports Server (NTRS)

Shen, Bo-Wen

2013-01-01

Storm Sandy first appeared as a tropical storm in the southern Caribbean Sea on Oct. 22, 2012, moved northeastward, turned northwestward, and made landfall near Brigantine, New Jersey in late October. Sandy devastated surrounding areas, caused an estimated damage of $50 billion, and became the second costliest tropical cyclone (TC) in U.S. History surpassed only by Hurricane Katrina (2005). To save lives and mitigate economic damage, a central question to be addressed is to what extent the lead time of severe storm prediction such as Sandy can be extended (e.g., Emanuel 2012; Kerr 2012). In this study, we present 10 numerical experiments initialized at 00 and 1200 UTC Oct. 22-26, 2012, with the NASA coupled advanced global modeling and visualization systems (CAMVis). All of the predictions realistically capture Sandy's movement with the northwestward turn prior to its landfall. However, three experiments (initialized at 0000 UTC Oct. 22 and 24 and 1200 UTC Oct. 22) produce larger errors. Among the 10 experiments, the control run initialized at 0000 UTC Oct. 23 produces a remarkable 7-day forecast. To illustrate the impact of environmental flows on the predictability of Sandy, we produce and discuss four-dimensional (4-D) visualizations with the control run. 4-D visualizations clearly demonstrate the following multiscale processes that led to the sinuous track of Sandy: the initial steering impact of an upper-level trough (appearing over the northwestern Caribbean Sea and Gulf of Mexico), the blocking impact of systems to the northeast of Sandy, and the binary interaction with a mid-latitude, upper-level trough that appeared at 130degrees west longitude on Oct. 23, moved to the East Coast and intensified during the period of Oct. 29-30 prior to Sandy's landfall.

Objective quantification of perturbations produced with a piecewise PV inversion technique

NASA Astrophysics Data System (ADS)

Fita, L.; Romero, R.; Ramis, C.

2007-11-01

PV inversion techniques have been widely used in numerical studies of severe weather cases. These techniques can be applied as a way to study the sensitivity of the responsible meteorological system to changes in the initial conditions of the simulations. Dynamical effects of a collection of atmospheric features involved in the evolution of the system can be isolated. However, aspects, such as the definition of the atmospheric features or the amount of change in the initial conditions, are largely case-dependent and/or subjectively defined. An objective way to calculate the modification of the initial fields is proposed to alleviate this problem. The perturbations are quantified as the mean absolute variations of the total energy between the original and modified fields, and an unique energy variation value is fixed for all the perturbations derived from different PV anomalies. Thus, PV features of different dimensions and characteristics introduce the same net modification of the initial conditions from an energetic point of view. The devised quantification method is applied to study the high impact weather case of 9-11 November 2001 in the Western Mediterranean basin, when a deep and strong cyclone was formed. On the Balearic Islands 4 people died, and sustained winds of 30 ms-1 and precipitation higher than 200 mm/24 h were recorded. Moreover, 700 people died in Algiers during the first phase of the event. The sensitivities to perturbations in the initial conditions of a deep upper level trough, the anticyclonic system related to the North Atlantic high and the surface thermal anomaly related to the baroclinicity of the environment are determined. Results reveal a high influence of the upper level trough and the surface thermal anomaly and a minor role of the North Atlantic high during the genesis of the cyclone.

Stratigraphic framework of Cambrian and Ordovician rocks in the central Appalachian Basin from Medina County, Ohio, through southwestern and south-central Pennsylvania to Hampshire County, West Virginia

USGS Publications Warehouse

Ryder, Robert T.; Harris, Anita G.; Repetski, John E.; revised and digitized by Crangle, Robert D.

2003-01-01

A 275-mi-long restored stratigraphic cross section from Medina County, Ohio, through southwestern and south-central Pennsylvania to Hampshire County, W. Va., provides new details on Cambrian and Ordovician stratigraphy in the central Appalachian basin and the structure of underlying Precambrian basement rocks. From west to east, the major structural elements of the block-faulted basement in this section are (1) the relatively stable, slightly extended craton, which includes the Wooster arch, (2) the fault-controlled Ohio-West Virginia hinge zone, which separates the craton from the adjoining Rome trough, (3) the Rome trough, which consists of an east-facing asymmetric graben and an overlying sag basin, and (4) a positive fault block, named here the South-central Pennsylvania arch, which borders the eastern margin of the graben part of the Rome trough. Pre-Middle Ordovician structural relief on Precambrian basement rocks across the down-to-the-west normal fault that separates the Rome trough and the adjoining South-central Pennsylvania arch amounted to between 6,000 and 7,000 ft. The restored cross section shows eastward thickening of the Cambrian and Ordovician sequence from about 3,000 ft near the crest of the Wooster arch at the western end of the section to about 5,150 ft at the Ohio-West Virginia hinge zone adjoining the western margin of the Rome trough to about 19,800 ft near the depositional axis of the Rome trough. East of the Rome trough, at the adjoining western edge of the South-central Pennsylvania arch, the Cambrian and Ordovician sequence thins abruptly to about 13,500 ft and then thins gradually eastward across the arch to about 12,700 ft near the Allegheny structural front and to about 10,150 ft at the eastern end of the restored section. In general, the Cambrian and Ordovician sequence along this section consists of four major lithofacies that are predominantly shallow marine to peritidal in origin. In ascending stratigraphic order, the lithofacies are identified by the following descriptive names: (1) sandstone, shale, limestone, and dolomite unit, (2) dolomite and sandstone unit, (3) limestone and black shale unit, and (4) shale and sandstone unit. Each of these units and their associated subunits thicken from west to east across the restored section to a maximum near the depositional axis of the Rome trough and then thin eastward to the end of the section. The sandstone, shale, limestone, and dolomite unit is largely confined to the asymmetric graben that marks the initial phase of the Rome trough. This unit is Early and Middle Cambrian in age and consists, in ascending order, of a basal sandstone unit (undrilled but probably present), the Tomstown Dolomite (undrilled but probably present), the Waynesboro Formation, and the Pleasant Hill Limestone and its equivalent lower one-third of the Elbrook Formation at the eastern end of the section. The dolomite and sandstone unit forms the core of the Cambrian and Ordovician sequence. In the Rome trough and on the adjoining South-central Pennsylvania arch, this unit consists, in ascending order, of the Middle and Upper Cambrian Warrior Formation and the equivalent upper two-thirds of the Elbrook Formation at the eastern end of the section, the Upper Cambrian Gatesburg Formation, and the Lower Ordovician and Middle Ordovician (Whiterockian and Chazyan) Beekmantown Group. West of the Ohio-West Virginia hinge zone, the dolomite and sandstone unit consists, in ascending order, of the Conasauga Formation of Janssens (1973), the Krysik sandstone of driller's usage, the B zone of Calvert (1964), the Knox Dolomite and the associated Rose Run Sandstone Member, and the Wells Creek Formation. The widespread Knox unconformity is located at the base of the Wells Creek Formation and at or near the top of the adjoining Beekmantown Group, except near the depositional axis of the Rome trough, where the unconformity seems to be absent. The limestone and black shale unit i

Climatology of the autumn Red Sea trough

NASA Astrophysics Data System (ADS)

Awad, Adel M.; Mashat, Abdul-Wahab S.

2018-03-01

In this study, the Sudan low and the associated Red Sea trough (RST) are objectively identified using the mean sea level pressure (SLP) data from the National Center for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis dataset covering the period 1955-2015. The Sudan low was detected in approximately 60.6% of the autumn periods, and approximately 83% of the detected low-pressure systems extended into RSTs, with most generated at night and during cold months. The distribution of the RSTs demonstrated that Sudan, South Sudan and Red Sea are the primary development areas of the RSTs, generating 97% of the RSTs in the study period. In addition, the outermost areas affected by RSTs, which include the southern, central and northern Red Sea areas, received approximately 91% of the RSTs originating from the primary generation areas. The synoptic features indicated that a Sudan low developed into an RST when the Sudan low deepened in the atmosphere, while the low pressures over the southern Arabian Peninsula are shallow and the anticyclonic systems are weakened over the northern Red Sea. Moreover, stabile areas over Africa and Arabian Peninsula form a high stability gradient around the Red Sea and the upper maximum winds weaken. The results of the case studies indicate that RSTs extend northward when the upper cyclonic and anticyclonic systems form a high geopotential gradient over Arabian Peninsula. Furthermore, the RST is oriented from the west to the east when the Azores high extends eastward and the Siberian high shrinks eastward or shifts northward.

Rifting Process and Geomorphic Development of the Okinawa Tough, Southwest Japan

NASA Astrophysics Data System (ADS)

Sato, T.; Arai, K.; Inoue, T.; Matsumoto, D.

2012-12-01

The Ryukyu Island Arc extends from Kyushu to Taiwan, a distance of 1,200 km, along the Ryukyu Trench where the Philippine Sea Plate is subducting beneath the Eurasian Plate. The Okinawa Trough, a back arc basin has formed behind the Ryukyu Island Arc in late Pliocene to early Pleistocene. The research cruises of GH11 (from 14 July to 15 August, 2011) and GH12 (from 20 to 30 July, 2012) were carried out around the Okinawa Trough. More than 3,600 miles multi channel high-resolution seismic profiles were acquired during these cruises by the GI-gun (Generator 250 cu inch and Injector 105 cu. inch) systems with 16ch digital streamer cable. As a result, two unconformities and three depositional sequence divided by the unconformities are recognized in the trough. The lower and the midlle sequence are tilted and blocked by many normal faults, on the other hand the upper one is not tilted and shows the pattern of onlap fill. From this result, the upper sequence started to deposit after start of the rifting. Additionally, internal reflection of the upper sequence shows the cyclic activities of the rifting. The position of the rifting axis was revealed based on dip of the normal faults. As a result, rifting axis shows echelon arrangement and the displacement of the faults are varied with the segment of the arrangement. The location of the segment boundaries is correlated with geometrical boundary of the adjacent slope. Steep slope with incised valley is distributed in southwestern part where the displacement of the normal fault is large, on the other hand, gentle slope without incised valley is distributed in northeastern part where the displacement is small. This difference of the displacement strongly controls the geometry of the adjacent slope.

Deep drivers of mesoscale circulation in the central Rockall Trough

NASA Astrophysics Data System (ADS)

Sherwin, T. J.; Alyenik, D.; Dumont, E.; Inall, M.

2014-11-01

Mesoscale variability in the central Rockall Trough between about 56 and 58° N has been investigated using a combination of ship-borne, underwater glider and gridded satellite altimeter measurements. Altimeter observations show that mesoscale features such as eddies and large scale circulation cells are ubiquitous phenomena. They have horizontal length scales of order 100 km with vertical scales of over 1000 m and are associated with mean current speeds (over the upper 1000 m) of 15 ± 7 cm s-1. Monthly area averaged surface Eddy Kinetic Energy (EKE) has substantial inter-annual variability, which at times can dominate a mean seasonal signal that varies from a maximum in May (74 cm2 s-2) to a minimum in October (52 cm2 s-2) and has increased gradually since 1992 at about 1.1 cm2 s-2 per year. A five month glider mission in the Trough showed that much of this energy comes from features that are located over 1000 m below the surface in the deep cold waters of the Trough (possibly from eddies associated the North Atlantic Current). The surface currents from altimeters had similar magnitude to the drift currents averaged over 1000 m from the glider in the stratified autumn, but were half the deep water speed during late winter. Although the mesoscale features move in an apparent random manner they may also be quasi-trapped by submarine topography such as seamounts. Occasionally anti-cyclonic and cyclonic cells combine to cause a coherent westward deflection of the European slope current that warms the Rockall side of the Trough. Such deflections contribute to the inter-annual variability in the observed temperature and salinity that are monitored in the upper 800 m of the Trough. By combining glider and altimeter measurements it is shown that altimeter measurements fail to observe a 15 cm s-1 northward flowing slope current on the eastern side and a small persistent southward current on the western side. There is much to be gained from the synergy between satellite altimetry and in situ glider observations both in the interpretation of their separate data sets and in aiding glider pilots to steer their vehicles through EKE active regions such as the north-east Atlantic.

Synoptic regimes associated with the eastern Mediterranean wet season cyclone tracks

NASA Astrophysics Data System (ADS)

Almazroui, Mansour; Awad, Adel M.

2016-11-01

The main synoptic patterns associated with the wet season (October-May) eastern Mediterranean cyclones have been analyzed and described using NCEP/NCAR reanalysis datasets for the period 1958-2013. The cyclone tracks detected in the eastern Mediterranean are classified into two types based on their positions: the local tracks and the long tracks. The local tracks are either stationary or short tracks. The long tracks distinguished into eleven very closed and highly correlated clusters, which are presented into three regimes namely the northern, the southern and the eastern border Mediterranean regimes. Among the 940 (44.78% of a total of 2099) long tracks, the northern, southern, and eastern border regime contributes respectively about 53.62%, 41.81% and 5% of the long tracks. In addition, the distribution of the long tracks reveals that a larger proportion of the cyclones are generated at the northern coast during November and spring months, while few cyclones are developed over the eastern Mediterranean border in warm months (April and May). Further, their synoptic features show that the regimes are associated with the extension of Azores high, specifically for each regime, the cyclogenesis areas of its clusters are controlled by the intersection of low level (850 hPa) trough and the position of the upper level (250 hPa) maximum wind. Furthermore, the orientations of clusters are controlled by the extension of Siberian high and the shape of cyclonic trough at 850 hPa. In addition, the synoptic study shows that most of the southern cyclones generated externally by African and Red Sea troughs, while most of the northern and eastern border cyclones are generated internally.

A comparison of observed and numerically predicted eddy kinetic energy budgets for a developing extratropical cyclone

NASA Technical Reports Server (NTRS)

Dare, P. M.; Smith, P. J.

1983-01-01

The eddy kinetic energy budget is calculated for a 48-hour forecast of an intense occluding winter cyclone associated with a strong well-developed jet stream. The model output consists of the initialized (1200 GMT January 9, 1975) and the 12, 24, 36, and 48 hour forecast fields from the Drexel/NCAR Limited Area Mesoscale Prediction System (LAMPS) model. The LAMPS forecast compares well with observations for the first 24 hours, but then overdevelops the low-level cyclone while inadequately developing the upper-air wave and jet. Eddy kinetic energy was found to be concentrated in the upper-troposphere with maxima flanking the primary trough. The increases in kinetic energy were found to be due to an excess of the primary source term of kinetic energy content, which is the horizontal flux of eddy kinetic energy over the primary sinks, and the generation and dissipation of eddy kinetic energy.

Meteorological and operational aspects of 46 clear air turbulence sampling missions with an instrument B-57B aircraft. Volume 1: Program summary

NASA Technical Reports Server (NTRS)

Davis, R. E.; Champine, R. A.; Ehernberger, L. J.

1979-01-01

The results of 46 clear air turbulence (CAT) probing missions conducted with an extensively instrumented B-57B aircraft are summarized. Turbulence samples were obtained under diverse conditions including mountain waves, jet streams, upper level fronts and troughs, and low altitude mechanical and thermal turbulence. CAT was encouraged on 20 flights comprising 77 data runs. In all, approximately 4335 km were flown in light turbulence, 1415 km in moderate turbulence, and 255 km in severe turbulence during the program. The flight planning, operations, and turbulence forecasting aspects conducted with the B-57B aircraft are presented.

A Numerical Study of Hurricane Erin (2001). Part 1; Model Verification and Storm Evolution

NASA Technical Reports Server (NTRS)

Wu, Liguang; Braun, Scott A.; Halverson, J.; Heymsfield, G.

2006-01-01

The fifth-generation Pennsylvania State University National Center for Atmospheric Research (PSU NCAR) Mesoscale Model (MM5) is used to simulate Hurricane Erin (2001) at high resolution (4-km spacing) from its early development as a tropical depression on 7 September 2001, through a period of rapid intensification into a strong hurricane (8 9 September), and finally into a stage during which it maintains its intensity on 10 September. These three stages of formation, intensification, and maintenance in the simulation are in good agreement with the observed evolution of Erin. The simulation shows that during the formation and early portions of the intensification stages, intensification is favored because the environmental wind shear is weak and the system moves over a warm tongue of water. As Erin intensifies, the wind shear gradually increases with the approach of an upper-level trough and strengthening of a low-level high pressure system. By 10 September, the wind shear peaks and begins to decrease, the storm moves over slightly cooler waters, and the intensification ends. Important structural changes occur at this time as the outer precipitation shifts from the northeastern and eastern sides to the western side of the eye. A secondary wind maximum and an outer eyewall begin to develop as precipitation begins to surround the entire eye. The simulation is used to investigate the role of vertical wind shear in the changes of the precipitation structure that took place between 9 and 10 September by examining the effects of changes in storm-relative flow and changes in the shear-induced tilt. Qualitative agreement is found between the divergence pattern and advection of vorticity by the relative flow with convergence (divergence) generally associated with asymmetric inflow (outflow) in the eyewall region. The shift in the outer precipitation is consistent with a shift in the low-level relative inflow from the northeastern to the northwestern side of the storm. The changes in the relative flow are associated with changes in the environmental winds as the hurricane moves relative to the upper trough and the low-level high pressure system. Examination of the shear-induced tilt of the vortex shows that the change in the tilt direction is greater than that of the shear direction as the tilt shifts from a northerly orientation to northwesterly. Consistent with theory for adiabatic vortices, the maximum low-level convergence and upper-level divergence (and the maximum upward motion) occurs in the direction of tilt. Consequently, both mechanisms may play roles in the changes in the precipitation pattern.

Morphotectonics of the central Muertos thrust belt and Muertos Trough (northeastern Caribbean)

USGS Publications Warehouse

Granja, Bruna J.L.; ten Brink, Uri S.; Carbó-Gorosabel, Andrés; Muñoz-Martín, A.; Gomez, Ballesteros M.

2009-01-01

Multibeam bathymetry data acquired during the 2005 Spanish R/V Hesp??rides cruise and reprocessed multichannel seismic profiles provide the basis for the analysis of the morphology and deformation in the central Muertos Trough and Muertos thrust belt. The Muertos Trough is an elongated basin developed where the Venezuelan Basin crust is thrusted under the Muertos fold-and-thrust belt. Structural variations along the Muertos Trough are suggested to be a consequence of the overburden of the asymmetrical thrust belt and by the variable nature of the Venezuelan Basin crust along the margin. The insular slope can be divided into three east-west trending slope provinces with high lateral variability which correspond to different accretion stages: 1) The lower slope is composed of an active sequence of imbricate thrust slices and closed fold axes, which form short and narrow accretionary ridges and elongated slope basins; 2) The middle slope shows a less active imbricate structure resulting in lower superficial deformation and bigger slope basins; 3) The upper slope comprises the talus region and extended terraces burying an island arc basement and an inactive imbricate structure. The talus region is characterized by a dense drainage network that transports turbidite flows from the islands and their surrounding carbonate platform areas to the slope basins and sometimes to the trough. In the survey area the accommodation of the ongoing east-west differential motion between the Hispaniola and the Puerto Rico-Virgin Islands blocks takes place by means of diffuse deformation. The asymmetrical development of the thrust belt is not related to the geological conditions in the foreland, but rather may be caused by variations in the geometry and movement of the backstop. The map-view curves of the thrust belt and the symmetry of the recesses suggest a main north-south convergence along the Muertos margin. The western end of the Investigator Fault Zone comprises a broad band of active normal faults which result in high instability of the upper insular slope. ?? 2009 Elsevier B.V.

New Insight Into the Crustal Structure of the Continental Margin offshore NW Sabah/Borneo

NASA Astrophysics Data System (ADS)

Barckhausen, U.; Franke, D.; Behain, D.; Meyer, H.

2002-12-01

The continental margin offshore NW Sabah/Borneo (Malaysia) has been investigated with reflection and refraction seismics, magnetics, and gravity during the recent cruise BGR01-POPSCOMS. A total of 4000 km of geophysical profiles has been acquired, thereof 2900 km with reflection seismics. The focus of investigations was on the deep water areas. The margin looks like a typical accretionary margin and was presumably formed during the subduction of a proto South China Sea. Presently, no horizontal movements between the two plates are being observed. Like in major parts of the South China Sea, the area seaward of the Sabah Trough consists of extended continental lithosphere which is characterised by a pattern of rotated fault blocks and half grabens and a carbonate platform of Early Oligocene to Early Miocene age. We found evidence that the continental crust also underlies the Sabah Trough and the adjacent continental slope, a fact that raises many questions about the tectonic history and development of this margin. The tectonic pattern of the Dangerous Grounds' extended continental crust can be traced a long way landward of the Sabah Trough beneath the sedimentary succession of the upper plate. The magnetic anomalies which are dominated by the magnetic signatures of relatively young volcanic features also continue under the continental slope. The sedimentary rocks of the upper plate, in contrast, seem to generate hardly any magnetic anomalies. Based on the new data we propose the following scenario for the development of the NW Sabah continental margin: Seafloor spreading in the present South China Sea started at about 30 Ma in the Late Oligocene. The spreading process separated the Dangerous Grounds area from the SE Asian continent and ceased in late Early Miocene when the oceanic crust of the proto South China Sea was fully subducted in eastward direction along the Borneo-Palawan Trough. During Lower and/or Middle Miocene, Borneo rotated counterclockwise and was thrusted onto the edge of the rifted continental block of the Dangerous Grounds. The subducted oceanic crust of the proto South China Sea must today be located below the Eastern part of Sabah and not along the present NW Sabah Trough.

[Successful cyclosporine treatment in 2 patients with refractory CIDP, involving monitoring of both AUC(0-4h) and trough levels].

PubMed

Takeuchi, Akiko; Shirai, Shinichi; Horiuchi, Kazuhiro; Takahashi, Ikuko; Matsushima, Masaaki; Hirotani, Makoto; Kano, Takahiro; Yabe, Ichiro; Matumoto, Akihisa; Sasaki, Hidenao

2012-01-01

Cyclosporine A (CYA) treatment has been reported to be probably useful for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that is resistant to conventional treatment. Although several studies have shown that appropriate area under the concentration-time curve (AUC) monitoring of CYA levels results in improved outcomes for refractory nephrotic syndrome patients, the importance of using AUC analysis for CIDP remains unclear. In this study, we measured both trough and AUC from 0 to 4 h (AUC(0-4 h)) levels of CYA in 2 patients with CIDP and compared the findings for the clinical parameters. On the basis of the CYA dosing recommendations for patients with nephrotic syndrome, we used a CYA concentration of 150 ng/ml for the trough level and an AUC(0-4 h) value of 2,500 ng/(ml·h). Patient 1 showed a significant increase in grip strength and a prolonged remission period. Patient 2 showed improvement in the modified Rankin scale and manual muscle test (MMT) scores. Monitoring both AUC(0-4 h) and trough levels of CYA seems to be a better option than monitoring the trough level alone because it leads to improved estimation of the efficacy and safety of CYA treatment in the case of CIDP patients.

The Pianosa Contourite Depositional System (Northern Tyrrhenian Sea): drift morphology and Plio-Quaternary stratigraphic evolution

NASA Astrophysics Data System (ADS)

Miramontes Garcia, Elda; Cattaneo, Antonio; Jouet, Gwenael; Thereau, Estelle; Thomas, Yannick; Rovere, Marzia; Cauquil, Eric; Trincardi, Fabio

2016-04-01

The Pianosa Contourite Depositional System (CDS) is located in the Corsica Trough (Northern Tyrrhenian Sea), a confined basin dominated by mass transport and contour currents in the eastern flank and by turbidity currents in the western flank. The morphologic and stratigraphic characterisation of the Pianosa CDS is based on multibeam bathymetry, seismic reflection data (multi-channel high resolution mini GI gun, single-channel sparker and CHIRP), sediment cores and ADCP data. The Pianosa CDS is located at shallow to intermediate water depths (170 to 850 m water depth) and is formed under the influence of the Levantine Intermediate Water (LIW). It is 120 km long, has a maximum width of 10 km and is composed of different types of muddy sediment drifts: plastered drift, separated mounded drift, sigmoid drift and multicrested drift. The reduced tectonic activity in the Corsica Trough since the early Pliocene permits to recover a sedimentary record of the contourite depositional system that is only influenced by climate fluctuations. Contourites started to develop in the Middle-Late Pliocene, but their growth was enhanced since the Middle Pleistocene Transition (0.7-0.9 Ma). Although the general circulation of the LIW, flowing northwards in the Corsica Trough, remained active all along the history of the system, contourite drift formation changed, controlled by sediment influx and bottom current velocity. During periods of sea level fall, fast bottom currents often eroded the drift crest in the middle and upper slope. At that time the proximity of the coast to the shelf edge favoured the formation of bioclastic sand deposits winnowed by bottom currents. Higher sediment accumulation of mud in the drifts occurred during periods of fast bottom currents and high sediment availability (i.e. high activity of turbidity currents), coincident with periods of sea level low-stands. Condensed sections were formed during sea level high-stands, when bottom currents were more sluggish and the turbidite system was disconnected, resulting in a lower sediment influx.

Crustal Structure in the Southern Rockall Trough from Satellite Gravity Data: Evidence for Sea-floor Spreading

NASA Astrophysics Data System (ADS)

Chappell, A.; Kusznir, N. J.

2005-05-01

The southern Rockall Trough south of 57 N has previously been interpreted as either an intra-continental rift floored with highly extended continental crust, or a failed oceanic rift formed by Cretaceous sea floor spreading. Satellite gravity, bathymetry data and seismic estimates of sediment thickness are used to derive crustal basement thickness for the southern Rockall Trough and adjacent regions using a gravity inversion method incorporating a correction for the large negative thermal gravity component present in oceanic and stretched continental lithosphere. The marine Bouguer anomaly, derived from satellite free air gravity (Sandwell & Smith 1997) and Gebco 2003 bathymetry data, is inverted using the method of Oldenberg (1974), incorporating an iteratively applied thermal anomaly correction, to give Moho depth. For oceanic crust the thermal anomaly correction is calculated using isochron ages (Muller et al. 1997) and for continental crust from the beta stretching factors resulting from gravity derived crustal basement thickness and an assumed rift age. When sediment thickness and volcanic addition are assumed to be zero, the resulting upper bound of crustal thickness from the gravity inversion is as little as 10 km in the southern Rockall Trough. A segmented axial thickening of the crust at the centre of the Rockall Trough is predicted, between the Barra volcanic ridge and the Anton Dohrn seamount and is interpreted as having a volcanic origin. Inclusion of a sediment thickness correction in the gravity inversion further reduces predicted crustal thickness. A pseudo-sediment-thickness map has been constructed from the available wide-angle data and incorporated in the gravity inversion. The addition of up to 5.5 km of sediment in the gravity inversion reduces the upper bound of crustal thickness to less than 3 km in some locations. The segmented axial thickening and thin crust shown by the gravity inversion, the lack of intra-basinal faulting, and the volcanic origin for the axis shown by normal incidence seismic data, are consistent with a sea-floor spreading origin for the southern Rockall Trough and not formation by intra-continental rifting. We investigate the formation of the southern Rockall Trough using SfMargin, a new model of continental lithosphere thinning leading to continental breakup and sea-floor spreading initiation. Comparisons of the geometry of the southern Rockall Trough predicted by SfMargin with that observed are consistent with a short period (20Ma) of slow Cretaceous sea-floor spreading, followed by thermal subsidence to present day. This work forms part of the NERC Margins iSIMM project. iSIMM investigators are from Liverpool and Cambridge Universities, Badley Geoscience & Schlumberger Cambridge Research supported by the NERC, the DTI, Agip UK, BP, Amerada Hess Ltd, Anadarko, ConocoPhillips, Shell, Statoil and WesternGeco. The iSIMM team comprises NJ Kusznir, RS White, AM Roberts, PAF Christie, A Chappell, J Eccles, R Fletcher, D Healy, N Hurst, ZC Lunnon, CJ Parkin, AW Roberts, LK Smith, V Tymms & R Spitzer.

Landing Trail in 3-D

NASA Technical Reports Server (NTRS)

2004-01-01

A three-dimensional color model created using data from the Mars Exploration Rover's panoramic camera shows images of airbag drag marks on the martian surface. The triangular rock in the upper left corner is approximately 20 centimeters (8 inches) tall. The meatball-shaped rock in the upper right corner is approximately 10 centimeters (4 inches) tall. The dark portion of the surface, or 'trough' is approximately 1 centimeter (0.4 inches) deep at its deepest point. This model is displayed using software developed by NASA's Ames Research Center.

Adalimumab for Treatment of Noninfectious Uveitis: Immunogenicity and Clinical Relevance of Measuring Serum Drug Levels and Antidrug Antibodies.

PubMed

Cordero-Coma, Miguel; Calleja-Antolín, Sara; Garzo-García, Irene; Nuñez-Garnés, Ana M; Álvarez-Castro, Carolina; Franco-Benito, Manuel; Ruiz de Morales, Jose G

2016-12-01

To evaluate the rate of immunogenicity induced by adalimumab and its relationship with drug serum levels and clinical responses in patients with noninfectious uveitis. Prospective observational study. Consecutive patients from 1 referral center who initiated treatment with adalimumab for active noninfectious uveitis resistant to conventional therapy. All patients received 40 mg adalimumab every other week. Patients were evaluated clinically and immunologically before and after 4, 8, and 24 weeks of treatment. Clinical evaluation included assessment of changes in visual acuity, degree of inflammation in the anterior chamber and vitreous cavity, central macular thickness, and retinal angiographic leakage. Immunologic evaluation included assessment of serum trough adalimumab and antibodies against adalimumab (AAA) levels and class II HLA typing. Twenty-five patients were enrolled. Overall, 18 of 25 patients (72%) showed a favorable clinical response to adalimumab therapy. Eleven patients (44%) achieved a complete response and 7 (28%) achieved a partial response. However, 7 of 25 patients (28%) were considered nonresponders. Median trough adalimumab serum levels were higher in responders than in nonresponders (P < 0.001). We observed AAA positivity (AAA+) at least 1 time point in 8 of 25 patients (32%), including 4 with transitory AAA and 4 with permanent AAA. In all patients with permanent AAA+, trough adalimumab levels became undetectable (P < 0.001). However, in patients who demonstrated transitory AAA+, no correlation was observed between AAA titers and adalimumab trough levels (P = 0.2).Concomitant immunosuppression did not show any protective effect on adalimumab immunogenicity in our cohort. An association between the presence of AAA+ and a worse uveitis outcome was observed only in patients with permanent AAA+, which correlated with undetectable adalimumab trough levels (P = 0.014). Treatment of noninfectious uveitis with adalimumab is associated with high rates of favorable clinical response. Overall, adalimumab trough levels were higher in responder patients. Development of permanent AAA was associated with undetectable trough adalimumab levels and worse uveitis outcome. Immunogenicity was more common in patients in whom uveitis was associated with a systemic disease and was not influenced by concomitant immunosuppressors. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Small and Young

NASA Image and Video Library

2015-03-20

Small graben, narrow linear troughs, have been found associated with small scarps (bottom left, white arrows) on Mercury and the Moon. These graben (bottom right, white arrows) likely resulted from the bending and extension of the upper crust in response to scarp formation (bottom illustration) and are only tens of meters wide. On the basis of the rate of degradation and infilling of small troughs on the Moon by continuous meteoroid bombardment, small lunar graben and their associated scarps are less than 50 Myr old! It is likely that Mercury's small graben and their associated scarps are younger still, because the cratering rate on Mercury is greater than on the Moon. http://photojournal.jpl.nasa.gov/catalog/PIA19254

Collapse Pits

NASA Technical Reports Server (NTRS)

2005-01-01

24 April 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a large and several small pits formed by collapse along the trend of a fault system in the Uranius Fossae region of Mars. Running diagonal from middle-right toward lower left is a trough that intersects the pit. The trough is a typical graben formed by faulting as the upper crust of Mars split and pulled apart at this location. The opening of the graben also led to formation of the collapse pits.

Location near: 26.2oN, 88.7oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Summer

Ocular Penetration and Anti-inflammatory Activity of Ketorolac 0.45% and Bromfenac 0.09% Against Lipopolysaccharide-Induced Inflammation

PubMed Central

Galindo, Danielle; Villanueva, Linda; Nguyen, Cathy; Patel, Milan; Borbridge, Lisa; Attar, Mayssa; Schiffman, Rhett M.; Hollander, David A.

2011-01-01

Abstract Purpose Anti-inflammatory activity of topical nonsteroidal anti-inflammatory drugs is mediated by suppression of cyclooxygenase (COX) isoenzymes. This study compared ocular penetration and inflammation suppression of topical ketorolac 0.45% and bromfenac 0.09% ophthalmic solutions in a rabbit model. Methods At hour 0, 36 rabbits received ketorolac 0.45%, bromfenac 0.09%, or an artificial tear 3 times once every 20 min. Half of the rabbits in each group then received intravenous injections of lipopolysaccharide (LPS) and fluorescein isothiocyanate (FITC)–dextran at hour 1, and the other half at hour 10. Aqueous and iris-ciliary body (ICB) samples were collected in the former group at hour 2 (peak) and in the latter group at hour 11 (trough) An additional group of 6 animals received only FITC-dextran, and samples were collected 1 h later. Peak and trough nonsteroidal anti-inflammatory drug concentrations were compared with previously determined half-maximal inhibitory concentrations (IC50) for COX isoenzymes. Results Peak and trough aqueous and ICB concentrations of ketorolac were at least 7-fold or greater than those of bromfenac. At peak levels, both ketorolac 0.45% and bromfenac 0.09% significantly inhibited LPS-induced aqueous prostaglandin E2 and FITC-dextran elevation (P < 0.01). At trough, both study drugs significantly inhibited LPS-induced aqueous prostaglandin E2 elevation (P < 0.05), but only ketorolac 0.45% significantly reduced LPS-induced aqueous FITC-dextran elevation (P < 0.01). Aqueous and ICB ketorolac concentrations exceeded its IC50 for COX-1 and COX-2 at peak and trough. Aqueous and ICB bromfenac levels exceeded its IC50 for COX-2 at peak and trough, but not for COX-1 at trough aqueous levels and peak and trough ICB levels. Conclusions Both ketorolac 0.45% and bromfenac 0.09% effectively suppressed inflammation at peak. At trough, only ketorolac 0.45% effectively suppressed inflammation as measured by FITC-dextran leakage. The difference in inflammation suppression may be due to differences in tissue concentrations and/or greater COX-1 suppression by ketorolac 0.45%. PMID:21351868

Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity.

PubMed

Inciarte-Mundo, José; Ramirez, Julio; Hernández, Maria Victoria; Ruiz-Esquide, Virginia; Cuervo, Andrea; Cabrera-Villalba, Sonia Raquel; Pascal, Mariona; Yagüe, Jordi; Cañete, Juan D; Sanmarti, Raimon

2016-07-08

Serum levels of calprotectin, a major S100 leucocyte protein, are associated with disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients. Higher drug trough serum levels are associated with good response in patients treated with tumour necrosis factor inhibitors (TNFi). Power Doppler ultrasound (PDUS) synovitis is predictive of flare and progression of structural damage in patients in clinical remission. The purpose of this study was to analyse the accuracy of calprotectin and TNFi trough serum levels in detecting PDUS synovitis in RA and PsA patients in clinical remission or with low disease activity who were receiving TNFi. We conducted a cross-sectional study of 92 patients (42 with RA, 50 with PsA) receiving adalimumab (ADA), etanercept (ETN) or infliximab who were in remission or had low disease activity (28-joint Disease Activity Score based on erythrocyte sedimentation rate <3.2). Associations of calprotectin, TNFi trough serum levels and acute phase reactants with PDUS synovitis were assessed using correlation and linear regression analyses. The accuracy and discriminatory capacity in detecting PDUS synovitis was assessed using ROC curves. PDUS synovitis was found in 62.4 % of RA patients and 32 % of PsA patients. Both RA and PsA patients with PDUS synovitis had higher calprotectin levels and lower TNFi trough serum levels. Calprotectin positively correlated with ultrasound scores (all r coefficients >0.50 in RA). Calprotectin correlated with the PDUS synovitis score in patients treated with ADA and ETN. Using PDUS synovitis (yes or no) as the reference variable, calprotectin had an AUC of 0.826. The best cut-off was ≥1.66 μg/ml, with a likelihood ratio of 2.77. C-reactive protein (AUC 0.673) and erythrocyte sedimentation rate (AUC 0.731) had a lower discriminatory capacity. TNFi trough serum levels were significantly associated with PDUS synovitis (OR 0.67, 95 % CI 0.52-0.85, p < 0.001) but their accuracy (AUC <0.5) was less than that of calprotectin. TNFi trough serum levels were inversely correlated with calprotectin and PDUS synovitis in RA and PsA patients receiving ADA and ETN. Calprotectin and TNFi trough serum levels may help identify PDUS synovitis in RA and PsA patients in clinical remission or with low disease activity.

New Insight Into The Crustal Structure of The Continental Margin Off NW Sabah/borneo

NASA Astrophysics Data System (ADS)

Barckhausen, U.; Franke, D.; Behain, D.; Meyer, H.

The continental margin offshore NW Sabah/Borneo (Malaysia) has been investigated with reflection and refraction seismics, magnetics, and gravity during the recent cruise BGR01-POPSCOMS. A total of 4000 km of geophysical profiles has been acquired, thereof 2900 km with reflection seismics. Like in major parts of the South China Sea, the area seaward of the Sabah Trough consists of extended continental lithosphere. We found evidence that the continental crust also underlies the continental slope land- ward of the Trough, a fact that raises many questions about the tectonic history and development of this margin. The characteristic pattern of rotated fault blocks and half grabens and the carbon- ates which are observed all over the Dangerous Grounds can be traced a long way landward of the Sabah Trough beneath the sedimentary succession of the upper plate. The magnetic anomalies which are dominated by the magnetic signatures of relatively young volcanic features also continue under the continental slope. The sedimentary rocks of the upper plate, in contrast, seem to generate hardly any magnetic anoma- lies. We suspect that the volcanic activity coincided with the collision of Borneo and the Dangerous Grounds in middle or late Miocene time. The emplacement of an al- lochtonous terrane on top of the extended continental lithosphere could be explained by overthrusting as a result of the collision or it could be related to gravity sliding following a broad uplift of NW Borneo at the same time.

Nuclear reactor sealing system

DOEpatents

McEdwards, James A.

1983-01-01

A liquid metal-cooled nuclear reactor sealing system. The nuclear reactor includes a vessel sealed at its upper end by a closure head. The closure head comprises at least two components, one of which is rotatable; and the two components define an annulus therebetween. The sealing system includes at least a first and second inflatable seal disposed in series in an upper portion of the annulus. The system further includes a dip seal extending into a body of insulation located adjacent a bottom portion of the closure head. The dip seal comprises a trough formed by a lower portion of one of the components, and a seal blade pendently supported from the other component and extending downwardly into the trough. A body of liquid metal is contained in the trough which submerges a portion of the seal blade. The seal blade is provided with at least one aperture located above the body of liquid metal for providing fluid communication between the annulus intermediate the dip seal and the inflatable seals, and a body of cover gas located inside the vessel. There also is provided means for introducing a purge gas into the annulus intermediate the inflatable seals and the seal blade. The purge gas is introduced in an amount sufficient to substantially reduce diffusion of radioactive cover gas or sodium vapor up to the inflatable seals. The purge gas mixes with the cover gas in the reactor vessel where it can be withdrawn from the vessel for treatment and recycle to the vessel.

Gas potential of the Rome Trough in Kentucky: Results of recent Cambrian exploration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harris, D.C.; Drahovzal, J.A.

1996-09-01

A recent gas discovery in the Rome Trough suggests the need to re-evaluate the deep Cambrian potential of eastern Kentucky. A new phase of Cambrian exploration began in mid-1994 with a new pool discovery by the Carson Associates No. 1 Kazee well in Elliott County, Ky. This well blew out and initially flowed 11 MMcfd of gas from the upper Conasauga Group/Rome Formation at 6,258 to 6,270 feet. After this discovery, a second exploratory well (the Blue Ridge No. 1Greene) was drilled on a separate structure in Elliott County in late 1995. The Blue Ridge well was temporarily abandoned, butmore » had shows of gas and condensate. In early 1996, Carson Associates offset their initial discovery well with the No. 33 Lawson Heirs well. This activity follows a frustrating exploration history in the Rome Trough that is marked by numerous gas and oil shows, but rare commercial production. Only three single-well pools have produced commercial gas from the trough, including the recent Kazee well. Stratigraphic units below the Cambrian-Ordovician Knox Group in the Rome Trough are dramatically thicker than their equivalents on the shelf to the north. The interval in the trough is thought to include rocks as old as Early Cambrian, consisting of a basal sandstone, equivalents of the Shady/Tomstown Dolomite, the Rome Formation, and the Conasauga Formation. Sandstones and fractured shales have been responsible for most of the production to date, but dolostone intervals may also have potential. Limited seismic data indicate possible fan-delta and basin-floor fan deposits that may have reservoir potential.« less

Extreme Mesozoic crustal thinning in the Eastern Iberia margin: The example of the Columbrets Basin (Valencia Trough)

NASA Astrophysics Data System (ADS)

Mohn, G.; Etheve, N.; Frizon de Lamotte, D.; Roca, E.; Tugend, J.; Gómez-Romeu, J.

2017-12-01

Eastern Iberia preserves a complex succession of Mesozoic rifts partly or completely inverted during the Late Cretaceous and Cenozoic in relation with Africa-Eurasia convergence. Notably, the Valencia Trough, classically viewed as part of the Cenozoic West Mediterranean basins, preserves in its southwestern part a thick Mesozoic succession (locally »10km thick) over a highly thinned continental basement (locally only »3,5km thick). This sub-basin referred to as the Columbrets Basin, represents a Late Jurassic-Early Cretaceous hyper-extended rift basin weakly overprinted by subsequent events. Its initial configuration is well preserved allowing us to unravel its 3D architecture and tectono-stratigraphic evolution in the frame of the Mesozoic evolution of eastern Iberia. The Columbrets Basin benefits from an extensive dataset combining high resolution reflection seismic profiles, drill holes, refraction seismic data and Expanding Spread Profiles. Its Mesozoic architecture is controlled by interactions between extensional deformation and halokinesis involving the Upper Triassic salt. The thick uppermost Triassic to Cretaceous succession describes a general synclinal shape, progressively stretched and dismembered towards the basin borders. The SE-border of the basin is characterized by a large extensional detachment fault acting at crustal scale and interacting locally with the Upper Triassic décollement. This extensional structure accommodates the exhumation of the continental basement and part of the crustal thinning. Eventually our results highlight the complex interaction between extreme crustal thinning and occurrence of a pre-rift salt level for the deformation style and tectono-stratigraphic evolution of hyper-extended rift basins.

Identification of large-scale meteorological patterns associated with extreme precipitation in the US northeast

NASA Astrophysics Data System (ADS)

Agel, Laurie; Barlow, Mathew; Feldstein, Steven B.; Gutowski, William J.

2018-03-01

Patterns of daily large-scale circulation associated with Northeast US extreme precipitation are identified using both k-means clustering (KMC) and Self-Organizing Maps (SOM) applied to tropopause height. The tropopause height provides a compact representation of the upper-tropospheric potential vorticity, which is closely related to the overall evolution and intensity of weather systems. Extreme precipitation is defined as the top 1% of daily wet-day observations at 35 Northeast stations, 1979-2008. KMC is applied on extreme precipitation days only, while the SOM algorithm is applied to all days in order to place the extreme results into the overall context of patterns for all days. Six tropopause patterns are identified through KMC for extreme day precipitation: a summertime tropopause ridge, a summertime shallow trough/ridge, a summertime shallow eastern US trough, a deeper wintertime eastern US trough, and two versions of a deep cold-weather trough located across the east-central US. Thirty SOM patterns for all days are identified. Results for all days show that 6 SOM patterns account for almost half of the extreme days, although extreme precipitation occurs in all SOM patterns. The same SOM patterns associated with extreme precipitation also routinely produce non-extreme precipitation; however, on extreme precipitation days the troughs, on average, are deeper and the downstream ridges more pronounced. Analysis of other fields associated with the large-scale patterns show various degrees of anomalously strong moisture transport preceding, and upward motion during, extreme precipitation events.

An analysis of the characteristics of extratropical cyclone Klaus

NASA Astrophysics Data System (ADS)

Gómara, Iñigo; Rodriguez-Puebla, Concepcion; Yague, Carlos

2010-05-01

Klaus was a very destructive extratropical cyclone that affected the south-west of Europe from the 23rd to the 25th of January 2009. In particular, it impacted over northern Spain, southern France and Italy where losses totalled billions of Euros and the death toll was 31. The extreme strength of the wind gusts generated by the storm was the main reason for the damage caused. Klaus had the properties of a cyclonic "bomb", and a brief meteorological description of the windstorm will be presented based on surface and upper-air reanalysis data. The analysis procedure has been based on earlier research carried out in this field by J. R. Gyakum (1980), Lance F. Bosart (1984) and J.R. Reed (1986). Klaus was formed under very favourable growing conditions in the North Atlantic ocean: a high atmospheric baroclinicity level due to high temperature and absolute humidity horizontal gradients and strong upper-air winds. In addition, the surface low that started as a stationary front interacted with a mobile upper trough that was located at an altitude of 9000 m near the surface low on the 23rd of January. A strong polar jet stream region above the surface incipient low was also located in the same region of the storm's growth, around 40W-42.5N. After its formation and interaction with the mobile upper-trough, Klaus moved very fast eastwards until it reached land in France on the 24th. We will discuss some social and economic impacts of the storm and the intervention of governments and weather services before, during and after the windstorm. References Gyakum, J. R. and F. Sanders, 1980: Synoptic-Dynamic Climatology of the "bomb". Monthly Weather Review, 108, 1589-1606. Bosart, L. F. and S.C. Lin, 1984: A diagnostic analysis of the Presidents' Day Storm of February 1979. Monthly Weather Review, 112, 2148-2177. Reed, J. R. and M. D. Albright, 1986: A case study of explosive cyclogenesis in the eastern Pacific. Monthly Weather Review, 114, 2297-2319.

Variational analysis of temperature and moisture advection in a severe storm environment

NASA Technical Reports Server (NTRS)

Mcfarland, M. J.; Sasaki, Y. K.

1977-01-01

Horizontal wind components, potential temperature, and mixing ratio fields associated with a severe storm environment in the south central United States were objectively analyzed from synoptic upper air observations with a nonhomogeneous anisotropic weighting function. The particular case study discussed here is the tornado producting squall line which moved through eastern Oklahoma 26 May 1973. The synoptic situation which preceded squall line development was cyclogenesis and frontogenesis in the lee-of-mountain trough, which produced a well-defined surface dry line (or dew point front) and a pronounced mid-level dry air intrusion. It is shown that the intrusion was also characterized by warm air, with a lapse rate approaching the dry adiabatic.

Experimental measurement and theoretical modeling of microwave scattering and the structure of the sea surface influencing radar observations from space

NASA Technical Reports Server (NTRS)

Arnold, David; Kong, J. A.

1992-01-01

The electromagnetic bias is an error present in radar altimetry of the ocean due to the non-uniform reflection from wave troughs and crests. A study of the electromagnetic bias became necessary to permit error reduction in mean sea level measurements of satellite radar altimeters. Satellite radar altimeters have been used to find the upper and lower bounds for the electromagnetic bias. This report will present a theory using physical optics scattering and an empirical model of the short wave modulation to predict the electromagnetic bias. The predicted electromagnetic bias will be compared to measurements at C and Ku bands.

Crustal Deformation In the Northwestern Margin of the South China Sea: Results From Wide-angle Seismic Modeling

NASA Astrophysics Data System (ADS)

Huang, H.; Klingelhoefer, F.

2017-12-01

The South China Sea (SCS) has undergone episodic spreading during the Cenozoic Era. The long-term extension has shaped the continental margins of the SCS, leading to a progressive breakup of the lithosphere. Separated blocks and rift troughs, as controlled by tectonic stretching, contains key information about the deforming mechanism of the crust. In this work, we present a P-wave velocity model of a wide-angle seismic profile OBS2013-1 which passes through the NW margin of the SCS. Modeling of 25 ocean bottom seismometers (OBS) data revealed a detailed crustal structure and shallow complexities along the profile (Figure 1). The crust thins symmetrically across the Xisha Trough, from more than 20 km on flanks to 10 km in the central valley where the sediments thickens over 5 km; A volcano is situated on top of the centre basement high where the Moho drops slightly. At the distal margin around the Zhongsha Trough, the upper crust was detached and accordingly made the middle crust exhumed in a narrow area ( 20 km wide). Meanwhile, materials from the lower crust rises asymmetrically, increasing the crustal velocity by 0.3 km/s and may also giving rise to volcanisms along the hanging side. A 40 km wide hyper-stretched crust (with thickness of 5 km) was identified next to the Zhongsha Trough and covered by overflowing magma and post-rift sediments on the top. These observations argue for a depth-related and asymmetrically extension of the crust, including (1) detachment fault controls the deformation of the upper crust, leading to exhumation of the middle crust and asymmetrically rising of the lower crust, (2) The region adjacent to the exhumation region and with highly thinned crust can be considered as extinct OCT due to magma-starved supplying.

Forearc sedimentation in Terraba Trough, Costa Rica, Central America

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yuan, P.B.; Lowe, D.R.

1987-05-01

Sedimentary rocks of Terraba Trough, Costa Rica, were deposited in a forearc basin developed at an ocean-ocean convergent boundary. The basin developed in the middle to late Eocene when the Farallon plate began its subduction beneath the Caribbean plate. Shallow-water carbonates of the Brito Formation were deposited on shoals of basement blocks. These were surrounded by deeper marine areas in which volcaniclastics and carbonate debris accumulated. The Brito Formation consists of algal-foraminiferal packstone to grainstone, rudstone, and rare wackestone formed in fore-slope, carbonate buildup, and open platform environments in a warm, tropical sea. The Eocene Brito Formation is overlain bymore » rocks of the upper Oligocene Rio Claro Member of the Terraba Formation. It is composed of rhodolite and bioclastic grainstone deposited in shallow water. A combination of little subsidence, mild volcanism, and possible erosion at about 30 Ma during a global drop of sea level may be responsible for the absence of lower Oligocene rocks in the study area. After the deposition of the Rio Claro Member, the area subsided rapidly to become a trough possibly deeper than 2000 m. Sedimentation took place in deep water from sediment gravity flows. In the early to early middle Miocene, coarser sediments and thicker sand units containing coal fragments became more abundant, suggesting that the basin was gradually filled. This study indicates that the timing and degree of subsidence of the fore-arc basin and the vertical variation in lithology are closely related to the variation in convergence rate between lithospheric plates in this part of Central America and the eastern Pacific.« less

Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn's disease.

PubMed

Drobne, David; Bossuyt, Peter; Breynaert, Christine; Cattaert, Tom; Vande Casteele, Niels; Compernolle, Griet; Jürgens, Matthias; Ferrante, Marc; Ballet, Vera; Wollants, Willem-Jan; Cleynen, Isabelle; Van Steen, Kristel; Gils, Ann; Rutgeerts, Paul; Vermeire, Severine; Van Assche, Gert

2015-03-01

The addition of immunomodulators increases the efficacy of maintenance therapy with infliximab for up to 1 year in patients with Crohn's disease who have not been previously treated with immunomodulators. However, there are questions about the effect of withdrawing immunomodulator therapy from these patients. We studied the effects of treatment with infliximab and immunomodulators (co-treatment) and then immunomodulator withdrawal on long-term outcomes of patients, as well as trough levels of infliximab and formation of anti-infliximab antibodies (ATI). In a retrospective study with the median follow-up period of 34 months (interquartile range, 19-58 months), we analyzed data from 223 patients treated for Crohn's disease between May 1999 and December 2010 at the University Hospitals, Leuven, Belgium (65 received infliximab monotherapy, 158 received infliximab and an immunomodulator). Trough levels of infliximab and levels of ATI were measured in blood samples collected from 117 patients throughout co-treatment, as well as the time of immunomodulator withdrawal and after withdrawal. Patients receiving co-treatment had higher trough levels of infliximab (adjusted mean increase, 1.44-fold) than those receiving infliximab monotherapy (95% confidence interval [CI], 1.07-1.92; P = .02). A smaller percentage of patients receiving co-treatment developed ATI (35 of 158, 22%) than those receiving infliximab monotherapy (25 of 65, 38%; P = .01). Among co-treated patients, levels of infliximab remained stable after immunomodulators were withdrawn (before: 3.2 μg/mL; 95% CI, 1.6-5.8 μg/mL and after: 3.7 μg/mL; 95% CI, 1.3-6.3 μg/mL; P = .70). After withdrawal of immunomodulators, 45 of 117 patients (38%) required increasing doses of infliximab, and 21 of 117 (18%) discontinued infliximab. At the time of immunomodulator withdrawal, trough levels of infliximab and C-reactive protein were most strongly associated with response to infliximab thereafter. In a retrospective analysis, we confirmed that withdrawal of immunomodulators after at least 6 months (median, 13 months) of co-treatment with infliximab does not reduce the trough levels of infliximab in patients with Crohn's disease. Detectable trough levels of infliximab at the time of immunomodulator withdrawal are associated with long-term response. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

Prospective Evaluation of a Model-Based Dosing Regimen for Amikacin in Preterm and Term Neonates in Clinical Practice

PubMed Central

De Cock, R. F. W.; Allegaert, K.; Vanhaesebrouck, S.; Danhof, M.; Knibbe, C. A. J.

2015-01-01

Based on a previously derived population pharmacokinetic model, a novel neonatal amikacin dosing regimen was developed. The aim of the current study was to prospectively evaluate this dosing regimen. First, early (before and after second dose) therapeutic drug monitoring (TDM) observations were evaluated for achieving target trough (<3 mg/liter) and peak (>24 mg/liter) levels. Second, all observed TDM concentrations were compared with model-predicted concentrations, whereby the results of a normalized prediction distribution error (NPDE) were considered. Subsequently, Monte Carlo simulations were performed. Finally, remaining causes limiting amikacin predictability (i.e., prescription errors and disease characteristics of outliers) were explored. In 579 neonates (median birth body weight, 2,285 [range, 420 to 4,850] g; postnatal age 2 days [range, 1 to 30 days]; gestational age, 34 weeks [range, 24 to 41 weeks]), 90.5% of the observed early peak levels reached 24 mg/liter, and 60.2% of the trough levels were <3 mg/liter (93.4% ≤5 mg/liter). Observations were accurately predicted by the model without bias, which was confirmed by the NPDE. Monte Carlo simulations showed that peak concentrations of >24 mg/liter were reached at steady state in almost all patients. Trough values of <3 mg/liter at steady state were documented in 78% to 100% and 45% to 96% of simulated cases with and without ibuprofen coadministration, respectively; suboptimal trough levels were found in patients with postnatal age <14 days and current weight of >2,000 g. Prospective evaluation of a model-based neonatal amikacin dosing regimen resulted in optimized peak and trough concentrations in almost all patients. Slightly adapted dosing for patient subgroups with suboptimal trough levels was proposed. This model-based approach improves neonatal dosing individualization. PMID:26248375

Evidence for Recent Liquid Water on Mars: Gullies in Sirenum Fossae Trough

NASA Technical Reports Server (NTRS)

2000-01-01

This mosaic of two Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) images shows about 20 different gullies coming down the south-facing wall of a trough in the Sirenum Fossae/Gorgonum Chaos region of the martian southern hemisphere. Each channel and its associated fan--or apron--of debris appears to have started just below the same hard, resistant layer of bedrock located approximately 100 meters (about 325 feet) below the top of the trough wall. The layer beneath this hard, resistant bedrock is interpreted to be permeable, which allows ground water to percolate through it and--at the location of this trough--seep out onto the martian surface. The channels and aprons only occur on the south-facing slope of this valley created by faults on each side of the trough. The depression is approximately 1.4 km (0.9 mi) across.

The mosaic was constructed from two pictures taken on September 16, 1999, and May 1, 2000. The black line is a gap between the two images that was not covered by MOC. The scene covers an area approximately 5.5 kilometers (3.4 miles) wide by 4.9 km (3.0 mi) high. Sunlight illuminates the area from the upper left. The image is located near 38.5oS, 171.3oW. MOC high resolution images are taken black-and-white (grayscale); the color seen here has been synthesized from the colors of Mars observed by the MOC wide angle cameras and by the Viking Orbiters in the late 1970s.

Seasonal Cycles of Oceanic Transports in the Eastern Subpolar North Atlantic

NASA Astrophysics Data System (ADS)

Gary, Stefan F.; Cunningham, Stuart A.; Johnson, Clare; Houpert, Loïc.; Holliday, N. Penny; Behrens, Erik; Biastoch, Arne; Böning, Claus W.

2018-02-01

The variability of the Atlantic Meridional Overturning Circulation (AMOC) may play a role in sea surface temperature predictions on seasonal to decadal time scales. Therefore, AMOC seasonal cycles are a potential baseline for interpreting predictions. Here we present estimates for the seasonal cycle of transports of volume, temperature, and freshwater associated with the upper limb of the AMOC in the eastern subpolar North Atlantic on the Extended Ellett Line hydrographic section between Scotland and Iceland. Due to weather, ship-based observations are primarily in summer. Recent glider observations during other seasons present an opportunity to investigate the seasonal variability in the upper layer of the AMOC. First, we document a new method to quality control and merge ship, float, and glider hydrographic observations. This method accounts for the different spatial sampling rates of the three platforms. The merged observations are used to compute seasonal cycles of volume, temperature, and freshwater transports in the Rockall Trough. These estimates are similar to the seasonal cycles in two eddy-resolving ocean models. Volume transport appears to be the primary factor modulating other Rockall Trough transports. Finally, we show that the weakest transports occur in summer, consistent with seasonal changes in the regional-scale wind stress curl. Although the seasonal cycle is weak compared to other variability in this region, the amplitude of the seasonal cycle in the Rockall Trough, roughly 0.5-1 Sv about a mean of 3.4 Sv, may account for up to 7-14% of the heat flux between Scotland and Greenland.

Geohydrology of the stratified-drift aquifer system in the lower Sixmile Creek and Willseyville Creek trough, Tompkins County, New York

USGS Publications Warehouse

Miller, Todd S.; Karig, Daniel E.

2010-01-01

In 2002, the U.S. Geological Survey, in cooperation with the Tompkins County Planning Department began a series of studies of the stratified-drift aquifers in Tompkins County to provide geohydrologic data for planners to develop a strategy to manage and protect their water resources. This aquifer study in lower Sixmile Creek and Willseyville Creek trough is the second in a series of aquifer studies in Tompkins County. The study area is within the northern area of the Appalachian Plateau and extends about 9 miles from the boundary between Tompkins County and Tioga County in the south to just south of the City of Ithaca in the north. In lower Sixmile Creek and Willseyville Creek trough, confined sand and gravel aquifers comprise the major water-bearing units while less extensive unconfined units form minor aquifers. About 600 people who live in lower Sixmile Creek and Willseyville Creek trough rely on groundwater from the stratified-drift aquifer system. In addition, water is used by non-permanent residents such as staff at commercial facilities. The estimated total groundwater withdrawn for domestic use is about 45,000 gallons per day (gal/d) or 0.07 cubic foot per second (ft3/s) based on an average water use of 75 gal/d per person for self-supplied water systems in New York. Scouring of bedrock in the preglacial lower Sixmile Creek and Willseyville Creek valleys by glaciers and subglacial meltwaters truncated hillside spurs, formed U-shaped, transverse valley profiles, smoothed valley walls, and deepened the valleys by as much as 300 feet (ft), forming a continuous trough. The unconsolidated deposits in the study area consist mostly of glacial drift, both unstratified drift (till) and stratified drift (laminated lake, deltaic, and glaciofluvial sediments), as well as some post-glacial stratified sediments (lake-bottom sediments that were deposited in reservoirs, peat and muck that were deposited in wetlands, and alluvium deposited by streams). Multiple advances and retreats of the ice in the study area resulted in several sequences of various types of glacial deposits. A large moraine (Valley Heads Moraine) dominates the southern part of the study area, a large delta dominates the central part, and ground moraine (mostly till) dominates the northern part. Glacial sediments in the center of the lower Sixmile Creek and Willseyville Creek trough typically range from 150 to 200 ft but can be greater than 300 ft in some places. Where the sediments are composed of sand and gravel they form aquifers. In most parts of the lower Sixmile Creek and Willseyville Creek trough, there is an upper and a basal confined aquifer. However, underlying the central parts of the Brooktondale delta, there are as many as four confined aquifers, whereas in the northern part of the study area, only one extensive confined aquifer is present. The major sources of recharge to these confined aquifers are (1) direct infiltration of precipitation where confined aquifers crop out at land surface (mostly along the western trough wall in the southern and central parts of the study area and, to a lesser degree, along the eastern trough wall); (2) unchanneled surface and subsurface runoff from adjacent upland areas that seeps into the aquifer along the western trough walls; (3) subsurface flow from underlying till or bedrock at the lateral contacts at trough walls; (4) adjacent fine-grained stratified drift, especially when the aquifer is pumped; and (5) discharge from bedrock at the bottom and sides of the trough. In the central part of the study area, the surficial coarse-grained sediments (sand and gravel) comprise a delta near Brooktondale and form a small unconfined aquifer (0.3 square mile). Although much of the upper part of the delta has been removed by several aggregate mining operations, sufficient amounts of sand and gravel remain in most places to form a thin unconfined aquifer. The major sources of recharge to the unconfined aquifer are (1)

Topography of closed depressions, scarps, and grabens in the North Tharsis region of Mars: implications for shallow crustal discontinuities and graben formation

USGS Publications Warehouse

Davis, Philip A.; Tanaka, Kenneth L.; Golombek, Matthew P.

1995-01-01

Using Viking Orbiter images, detailed photoclinometric profiles were obtained across 10 irregular depressions, 32 fretted fractures, 49 troughs and pits, 124 solitary scarps, and 370 simple grabens in the north Tharsis region of Mars. These data allow inferences to be made on the shallow crustal structure of this region. The frequency modes of measured scarp heights correspond with previous general thickness estimates of the heavily cratered and ridged plains units. The depths of the flat-floored irregular depressions (55-175 m), fretted fractures (85-890 m), and troughs and pits (60-1620 m) are also similar to scarp heights (thicknesses) of the geologic units in which these depressions occur, which suggests that the depths of these flat-floored features were controlled by erosional base levels created by lithologic contacts. Although the features have a similar age, both their depths and their observed local structural control increase in the order listed above, which suggests that the more advanced stages of associated fracturing facilitated the development of these depressions by increasing permeability. If a ground-ice zone is a factor in development of these features, as has been suggested, our observation that the depths of these features decrease with increasing latitude suggests that either the thickness of the ground-ice zone does not increase poleward or the depths of the depressions were controlled by the top of the ground-ice zone whose depth may decrease with latitude. Deeper discontinuities are inferred from fault-intersection depths of 370 simple grabens (assuming 60° dipping faults that initiate at a mechanical discontinuity) in Tempe Terra and Alba Patera and from the depths of the large, flat-floored troughs in Tempe Terra. The frequency distributions of these fault-intersection and large trough depths show a concentration at 1.0-1.6 km depth, similar to data obtained for Syria, Sinai, and Lunae Plana. The consistency of these depth data over such a large region of western Mars suggests that a discontinuity or a process that transcends local and regional geology is responsible for the formation of these features. If this discontinuity is represented by the base of the cryosphere, its uniform depth over 55° of latitude suggests that the cryosphere did not thicken poleward. Alternatively, the concentration of depths at 1.0-1.6 km may represent the upper level of noneruptive dike ascent (lateral dike propagation) of Mars, which is controlled by gravity and atmospheric pressure and magma and country-rock characteristics, and was probably controlled, in part, by ground ice. Fault-intersection depths in the north Tharsis region locally extend down to a depth of 5-7 km. The depth data between 2 and 3 km are attributed to the discontinuity at the interface of megaregolith and basement or to the upper limit of noneruptive dike ascent of magma with a high volatile content. Intersection depths greater than 3 km, which were found at Alba Patera, may be due to the megaregolith-basement discontinuity, which was buried and depressed by volcanic loading, or to the upper level of noneruptive dike ascent of magma with a low volatile content. The near absence of narrow simple grabens with fault-initiation depths less than 0.6-1.0 km in this study area, as well as in most of western Mars, suggests that this depth represents the minimum depth that normal faults can initiate; at shallower depths tension cracks or joints would form instead. This hypothesis is supported by the application of the Griffith failure criterion to this minimum depth of normal fault initiation, which suggests that shallow crustal materials have a tensile strength of 2-4 MPa throughout most of western Mars, in close agreement with previous estimates of tensile strength of martian basaltic rock.

Identification of Risk Factors for Nephrotoxicity in Patients Receiving Extended-Duration, High-Trough Vancomycin Therapy

PubMed Central

Contreiras, Claire; Legal, Michael; Lau, Tim T Y; Thalakada, Rosanne; Shalansky, Stephen; Ensom, Mary H H

2014-01-01

Background: In the past, impurities in vancomycin formulations were thought to contribute to nephrotoxicity. In contrast, when current, purer formulations are dosed at conventional trough levels (i.e., 5–15 mg/L), the incidence of nephrotoxicity is relatively low. Recent guidelines have recommended targeting higher vancomycin trough levels in treatment of complicated methicillin-resistant Staphylococcus aureus infections. Dosing based on these higher trough levels may be associated with nephrotoxicity, so the potential risk factors for vancomycin-associated nephrotoxicity require clearer definition. Objectives: To determine the occurrence of nephrotoxicity in patients receiving more than 7 days of vancomycin therapy with high trough levels (15–20 mg/L) and to identify and evaluate specific risk factors related to development of vancomycin-associated nephrotoxicity (i.e., serum creatinine ≥ 44.2 μmol/L or increase ≥ 50% [i.e., ≥ 26.2 μmol/L] from baseline on 2 consecutive days). Methods: Health care records were reviewed for patients seen at 2 major teaching hospitals between January 2008 and March 2011. Patients who had attained high trough levels of vancomycin were screened for eligibility. Patients with unstable renal function, those undergoing hemodialysis, and those for whom dosage and/or sampling times were unclear were excluded. Univariate and multivariate analyses were performed to identify risk factors associated with nephrotoxicity. Univariate variables with p < 0.1 were included in the logistic regression model. Results: Of the 176 patients with high trough levels included in the analysis, 24 (14%) experienced nephrotoxicity. In univariate analysis, admission to a general medicine unit (the setting of care for 16 [67%] of the 24 patients with nephrotoxicity) and extended duration of vancomycin treatment were identified as risk factors for nephrotoxicity (p < 0.1). Other risk factors included gastrointestinal comorbidity (p = 0.056), malignancy (p = 0.044), and febrile neutropenia (p = 0.032). Multivariate analysis identified treatment on general medicine units and treatment courses longer than 7 days as independent predictors of vancomycin-associated nephrotoxicity. Conclusion: Patients being treated on general medicine units and those receiving vancomycin for more than 7 days had an increased likelihood of experiencing nephrotoxicity. The increased risk for patients on general medicine units is likely multifactorial. The relationship between treatment duration and risk of nephrotoxicity appeared to be linear. When using extended-duration, high-trough vancomycin therapy, clinicians should be vigilant in monitoring for nephrotoxicity. PMID:24799722

The North American winter 'dipole' and extremes activity: A CMIP5 assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Shih-Yu Simon; Huang, Wan -Ru; Yoon, Jin -Ho

The 2013-2014 winter in North American brought intense drought in the West and severe cold in the East. The circulation anomalies were characterized as a dipole: an amplified upper-level ridge over the West Coast and a deepened trough over the central-eastern United States. A previous study using a single model has linked the dipole to the El Nino precursor and found that this link has strengthened in recent years. Here, 17 models from the Coupled Model Intercomparison Project Phase 5 are used to examine the dipole activity. As a result, most models capture the dipole and its association with Elmore » Nino precursor and project this association to strengthen.« less

Numerical model-based diagnostic study of the rapid development phase of the Presidents' Day cyclone

NASA Technical Reports Server (NTRS)

Whitaker, Jeffrey S.; Uccellini, Louis W.; Brill, Keith F.

1988-01-01

A mesoscale model simulation of the Presidents' Day cyclone at 1200 GMT 18 February 1979 is presented which captures the upper-tropospheric intrusion of stratospheric air upstream of the East Coast and subsequent development of the surface cyclone. The model simulation is then used to examine the descent of the stratospheric air mass and the interaction of this air mass with a lower-tropospheric potential vorticity maximum associated with an inverted trough and coastal front along the East Coast. The model is also used to examine the processes that contribute to the rapid decrease of sea-level pressure and increase in lower-tropospheric cyclonic vorticity during the explosive development phase of the cyclone.

The North American winter 'dipole' and extremes activity: A CMIP5 assessment

DOE PAGES

Wang, Shih-Yu Simon; Huang, Wan -Ru; Yoon, Jin -Ho

2015-02-13

The 2013-2014 winter in North American brought intense drought in the West and severe cold in the East. The circulation anomalies were characterized as a dipole: an amplified upper-level ridge over the West Coast and a deepened trough over the central-eastern United States. A previous study using a single model has linked the dipole to the El Nino precursor and found that this link has strengthened in recent years. Here, 17 models from the Coupled Model Intercomparison Project Phase 5 are used to examine the dipole activity. As a result, most models capture the dipole and its association with Elmore » Nino precursor and project this association to strengthen.« less

Geomorphology and Geology of the Southwestern Margaritifer Sinus and Argyre Regions of Mars. Part 1: Geological and Geomorphological Overview

NASA Technical Reports Server (NTRS)

Parker, T. J.; Pieri, D. C.

1985-01-01

Based upon Viking Orbiter 1 images of the southwestern portion of the Margaritifer Sinus Quadrangle, the northwestern portion of the Argyre Quadrangle, and a small portion of the southeastern Coprates Quadrangle, three major mountainous of plateau units, seven plains units, and six units related to valley forming processes were identified. The photomosaic is oriented such that it provides good areal coverage of the upper Chryse Trough from Argyre Planitia to just above Margaritifer Chaos as well as of plains units on either side of the Trough. The photomosaic was compiled from Viking Orbiter 1 images ranging in resolution from approximately 150 to 300 meters per pixel printed at a scale of about 1:2,000,000. The characteristics of each geomorphic unit are outlined.

Microplastic pollution identified in deep-sea water and ingested by benthic invertebrates in the Rockall Trough, North Atlantic Ocean.

PubMed

Courtene-Jones, Winnie; Quinn, Brian; Gary, Stefan F; Mogg, Andrew O M; Narayanaswamy, Bhavani E

2017-12-01

Microplastics are widespread in the natural environment and present numerous ecological threats. While the ultimate fate of marine microplastics are not well known, it is hypothesized that the deep sea is the final sink for this anthropogenic contaminant. This study provides a quantification and characterisation of microplastic pollution ingested by benthic macroinvertebrates with different feeding modes (Ophiomusium lymani, Hymenaster pellucidus and Colus jeffreysianus) and in adjacent deep water > 2200 m, in the Rockall Trough, Northeast Atlantic Ocean. Despite the remote location, microplastic fibres were identified in deep-sea water at a concentration of 70.8 particles m -3 , comparable to that in surface waters. Of the invertebrates examined (n = 66), 48% ingested microplastics with quantities enumerated comparable to coastal species. The number of ingested microplastics differed significantly between species and generalized linear modelling identified that the number of microplastics ingested for a given tissue mass was related to species and not organism feeding mode or the length or overall weight of the individual. Deep-sea microplastics were visually highly degraded with surface areas more than double that of pristine particles. The identification of synthetic polymers with densities greater and less than seawater along with comparable quantities to the upper ocean indicates processes of vertical re-distribution. This study presents the first snapshot of deep ocean microplastics and the quantification of microplastic pollution in the Rockall Trough. Additional sampling throughout the deep-sea is required to assess levels of microplastic pollution, vertical transportation and sequestration, which have the potential to impact the largest global ecosystem. Copyright © 2017 Elsevier Ltd. All rights reserved.

Weather And Death On Mount Everest: An Analysis Of The Into Thin Air Storm.

NASA Astrophysics Data System (ADS)

Moore, G. W. K.; Semple, John L.

2006-04-01

Scientific interest in Mount Everest has been largely focused on the physiology of hypoxia caused by the summit's low barometric pressure. Although weather is recognized as a significant risk for climbers on the mountain, it has not been extensively studied. In this paper, we reconstruct the meteorological conditions associated with the deadly outbreak of high-impact weather on Mount Everest that occurred in May 1996 and was the subject of the best-selling book Into Thin Air. The authors show that during this event, two jet streaks—an upper-level short-wave trough and an intrusion of stratospheric air into the upper troposphere—were present in the vicinity of Mount Everest. Meanwhile, in the lower troposphere, there was convergence of water vapor transport from both the Arabian Sea and the Bay of Bengal into the region to the south of Mount Everest. The authors propose that the ageostrophic circulation associated with the upper-level features resulted in a region of large-scale ascent near Mount Everest that, in combination with the anomalous availability of moisture in the region, triggered convective activity. The resulting high-impact weather trapped over 20 climbers on Mount Everest's exposed upper slopes leading to the deaths of 8. These synoptic-scale characteristics provide some expectation of predicting life-threatening high-altitude storms in the Himalayas. In addition, the authors argue that the falling barometric pressure and the presence of ozone-rich stratospheric air that occurred near the summit of Mount Everest during this event could have shifted a coping climber from a state of brittle tolerance to physiological distress.

Modeling temperature inversion in southeastern Yellow Sea during winter 2016

NASA Astrophysics Data System (ADS)

Pang, Ig-Chan; Moon, Jae-Hong; Lee, Joon-Ho; Hong, Ji-Seok; Pang, Sung-Jun

2017-05-01

A significant temperature inversion with temperature differences larger than 3°C was observed in the southeastern Yellow Sea (YS) during February 2016. By analyzing in situ hydrographic profiles and results from a regional ocean model for the YS, this study examines the spatiotemporal evolution of the temperature inversion and its connection with wind-induced currents in winter. Observations reveal that in winter, when the northwesterly wind prevails over the YS, the temperature inversion occurs largely at the frontal zone southwest of Korea where warm/saline water of a Kuroshio origin meets cold/fresh coastal water. Our model successfully captures the temperature inversion observed in the winter of 2016 and suggests a close relation between northwesterly wind bursts and the occurrence of the large inversion. In this respect, the strong northwesterly wind drove cold coastal water southward in the upper layer via Ekman transport, which pushed the water mass southward and increased the sea level slope in the frontal zone in southeastern YS. The intensified sea level slope propagated northward away from the frontal zone as a shelf wave, causing a northward upwind flow response along the YS trough in the lower layer, thereby resulting in the large temperature inversion. Diagnostic analysis of the momentum balance shows that the westward pressure gradient, which developed with shelf wave propagation along the YS trough, was balanced with the Coriolis force in accordance with the northward upwind current in and around the inversion area.

Predicting Tropical Cyclogenesis with a Global Mesoscale Model: Preliminary Results with Very Severe Cyclonic Storm Nargis (2008)

NASA Astrophysics Data System (ADS)

Shen, B.; Tao, W.; Atlas, R.

2008-12-01

Very Severe Cyclonic Storm Nargis, the deadliest named tropical cyclone (TC) in the North Indian Ocean Basin, devastated Burma (Myanmar) in May 2008, causing tremendous damage and numerous fatalities. An increased lead time in the prediction of TC Nargis would have increased the warning time and may therefore have saved lives and reduced economic damage. Recent advances in high-resolution global models and supercomputers have shown the potential for improving TC track and intensity forecasts, presumably by improving multi-scale simulations. The key but challenging questions to be answered include: (1) if and how realistic, in terms of timing, location and TC general structure, the global mesoscale model (GMM) can simulate TC genesis and (2) under what conditions can the model extend the lead time of TC genesis forecasts. In this study, we focus on genesis prediction for TCs in the Indian Ocean with the GMM. Preliminary real-data simulations show that the initial formation and intensity variations of TC Nargis can be realistically predicted at a lead time of up to 5 days. These simulations also suggest that the accurate representations of a westerly wind burst (WWB) and an equatorial trough, associated with monsoon circulations and/or a Madden-Julian Oscillation (MJO), are important for predicting the formation of this kind of TC. In addition to the WWB and equatorial trough, other favorable environmental conditions will be examined, which include enhanced monsoonal circulation, upper-level outflow, low- and middle-level moistening, and surface fluxes.

Potentiometric surfaces, summer 2013 and winter 2015, and select hydrographs for the Southern High Plains aquifer, Cannon Air Force Base, Curry County, New Mexico

USGS Publications Warehouse

Collison, Jake

2016-04-07

Cannon Air Force Base (Cannon AFB) is located in the High Plains physiographic region of east-central New Mexico, about 5 miles west of Clovis, New Mexico. The area surrounding Cannon AFB is primarily used for agriculture, including irrigated cropland and dairies. The Southern High Plains aquifer is the principal source of water for Cannon AFB, for the nearby town of Clovis, and for local agriculture and dairies. The Southern High Plains aquifer in the vicinity of Cannon AFB consists of three subsurface geological formations: the Chinle Formation of Triassic age, the Ogallala Formation of Tertiary age, and the Blackwater Draw Formation of Quaternary age. The Ogallala Formation is the main water-yielding formation of the Southern High Plains aquifer. Groundwater-supplied, center-pivot irrigation dominates pumping from the Southern High Plains aquifer in the area surrounding Cannon AFB, where the irrigation season typically extends from early March through October. The U.S. Geological Survey has been monitoring groundwater levels in the vicinity of Cannon AFB since 1954 and has developed general potentiometric-surface maps that show groundwater flow from northwest to southeast in the study area. While previous potentiometric-surface maps show the general direction of groundwater flow, a denser well network is needed to show details of groundwater flow at a local scale. Groundwater levels were measured in 93 wells during summer 2013 and 100 wells during winter 2015.The summer and winter potentiometric-surface maps display the presence of what is interpreted to be a groundwater trough trending from the northwest to the southeast through the study area. This groundwater trough may be the hydraulic expression of a Tertiary-age paleochannel. Groundwater north of the trough flows in a southerly direction into the trough, and groundwater south of the trough flows in an easterly direction into the trough.During the 18-month period between summer 2013 and winter 2015, changes in groundwater levels ranged from a rise of 10.0 to a decline of 3.8 feet. The regions to the north and south of the groundwater trough contained the majority of the rises in groundwater levels, whereas the regions within the trough contained the majority of the declines in groundwater levels. In contrast, the long-term groundwater-level trend in wells with 20 to 60 years of record is a steady decline in average annual water levels, with declines ranging from 0.41 to 2.81 feet per year. Overall, the northwestern part of the study area exhibits the smallest average annual declines, while the southeastern part of the study area exhibits the largest average annual declines.

Rossby waves, extreme fronts, and wildfires in southeastern Australia

NASA Astrophysics Data System (ADS)

Reeder, Michael J.; Spengler, Thomas; Musgrave, Ruth

2015-03-01

The most catastrophic fires in recent history in southern Australia have been associated with extreme cold fronts. Here an extreme cold front is defined as one for which the maximum temperature at 2 m is at least 17°C lower on the day following the front. An anticyclone, which precedes the cold front, directs very dry northerlies or northwesterlies from the interior of the continent across the region. The passage of the cold front is followed by strong southerlies or southwesterlies. European Centre for Medium-Range Weather Forecasts ERA-Interim Reanalyses show that this regional synoptic pattern common to all strong cold fronts, and hence severe fire conditions, is a consequence of propagating Rossby waves, which grow to large amplitude and eventually irreversibly overturn. The process of overturning produces the low-level anticyclone and dry conditions over southern Australia, while simultaneously producing an upper level trough and often precipitation in northeastern Australia.

Constraints on mantle melt geometries from body wave attenuation in the Salton Trough and Snake River Plain

NASA Astrophysics Data System (ADS)

Byrnes, J. S.; Bezada, M.

2017-12-01

Melt can be retained in the mantle at triple junctions between grain boundaries, be spread in thin films along two-grain boundaries, or be organized by shear into elongate melt-rich bands. Which of these geometries is most prevalent is unknown. This ambiguity makes the interpretation of anomalous seismic velocities and quality factors difficult, since different geometries would result in different mechanical effects. Here, we compare observations of seismic attenuation beneath the Salton Trough and the Snake River Plain; two regions where the presence of melt has been inferred. The results suggest that seismic attenuation is diagnostic of melt geometry. We measure the relative attenuation of P waves from deep focus earthquakes using a time-domain method. Even though the two regions are underlain by comparably strong low-velocity anomalies, their attenuation signature is very different. The upper mantle beneath the Salton Trough is sufficiently attenuating that the presence of melt must lower Qp, while attenuation beneath the Snake River Plain is not anomalous with respect to surrounding regions. These seemingly contradictory results can be reconciled if different melt geometries characterize each region. SKS splitting from the Salton Trough suggests that melt is organized into melt-rich bands, while this is not the case for the Snake River Plain. We infer that beneath the Snake River Plain melt is retained at triple junctions between grain boundaries, a geometry that is not predicted to cause seismic attenuation. More elongate geometries beneath the Salton Trough may cause seismic attenuation via the melt-squirt mechanism. In light of these results, we conclude that prior observations of low seismic velocities with somewhat high quality factors beneath the East Pacific Rise and Southern California suggest that melt does not organize into elongate bands across much of the asthenosphere.

Interaction between crustal tectonics and salt deformation in the Eastern Sardinian margin, Western Tyrrhenian Sea: seismic data and analogue modelling

NASA Astrophysics Data System (ADS)

Vendeville, Bruno; Lymer, Gael; Gaullier, Virginie; Chanier, Frank; Maillard, Agnes; Sage, Françoise; Lofi, Johanna; Thinon, Isabelle

2014-05-01

The Tyrrhenian Basin opened by eastward migration of the Apennine subduction system. Rifting along the Eastern Sardinian margin started during the middle to late Miocene times and hence this timing partly overlapped the Messinian Salinity Crisis. The two "METYSS" cruises were conducted to use the deformation of the Messinian salt and its Plio-Quaternary overburden as a proxy for better delineating the tectonic history of the sub-salt basement. Many parts of the study area contain two of the most typical Messinian series of the Western Mediterranean: the Mobile Unit (MU; salt, mainly halite), overlain by the more competent Upper Unit (UU: alternating dolomitic marls and anhydrite). The brittle Plio-Quaternary cover overlies the UU. Usually, the presence of mobile salt is viewed as a nuisance for understanding crustal tectonics because salt's ability to act as a structural buffer between the basement and the cover. However, we illustrate, using examples from the Cornaglia Terrace, how we can use thin-skinned salt tectonics as indicators of vertical movements in the sub-salt, pre-Messinian basement. There, slip along N-S-trending crustal normal faults bounding basement troughs has been recorded by salt and overburden in two different manners: - First, post-salt basement faulting (typically after deposition of the Upper Unit and the early Pliocene), and some crustal-scale southward tilting, triggered along-strike (southward) thin-skinned, gliding of salt and overburden recorded by upslope extension and downslope shortening. - Second, and less obvious at first glance, there was some crustal activity along another basement trough, located East of the Baronie Ridge after deposition of the Messinian salt. This trough is narrow, trends N-S and is bounded by crustal faults. The narrow width of the trough allowed for only minor across-strike (E-W) gliding. The resulting geometry would suggest that nothing happened after Messinian times, but some structural features (confirmed by analogue modelling) show that basement fault slip and tilting (Eastward or Westward) was accommodated by lateral flow of salt, which thinned upslope and inflated downslope, while the overlying sediments remained sub-horizontal.

From SYNOP to AMOC: Stirring by deep cyclones and the evolution of Denmark Strait Overflow Water observed at Line W

NASA Astrophysics Data System (ADS)

Andres, M.; Toole, J. M.; Torres, D. J.; Smethie, W. M., Jr.; Joyce, T. M.; Curry, R. G.

2016-02-01

Shipboard velocity and property data from 18 transects across the North Atlantic Deep Western Boundary Current (DWBC) near 40˚N are analyzed to study the evolution of the Denmark Strait Overflow Water (DSOW) component of the DWBC and its mixing with the interior. The transects were made between 1994 and 2014 and lie along Line W, which reaches from the continental shelf south of New England to Bermuda. Measurements comprise velocity from lowered acoustic Doppler current profilers (LADCPs), CTD profiles, and trace gas chlorofluorocarbon (CFC) concentrations from bottle samples at discrete depths at 26 regular stations or a subset of these stations. In each transect, DSOW exhibits a distinct CFC concentration maximum in the abyssal ocean (> 3000 m depth) along the sloped western boundary. Sea surface height (SSH) maps from satellite altimetry indicate that quasi-stationary meander troughs of the Gulf Stream path in the upper ocean were present at Line W during 5 of the 18 sections. For these 5 sections, the LADCP velocity sections suggest the upper ocean trough is accompanied by a large cyclone in the deep ocean in the DSOW density layer. The occurrence of deep cyclones in conjunction with Gulf Stream troughs as inferred from the LADCP sections along Line W is consistent with previous observations (from 1988 to 1990) in the region from a moored array in the Synoptic Ocean Prediction (SYNOP) experiment. The SYNOP array suggested deep cyclones are present here about 35% of the time. The composite velocity section produced from the 5 Line W transects sampling through a Gulf Stream trough suggests that a typical cyclone reaches swirl speeds of greater than 30 cm/s at 3400 m depth and has a radius (distance between the center and the maximum velocity) of 75 km. The tracer data suggest that these cyclones affect not only the deep velocity structure along Line W, but also provide a mechanism for water exchange between the DWBC and the interior.

Sirenum Fossae Trough

NASA Technical Reports Server (NTRS)

2000-01-01

[figure removed for brevity, see original site]

The Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) orbits the red planet twelve times each day. The number of pictures that MOC can take varies from orbit to orbit, depending upon whether the data are being stored in MGS's onboard tape recorder for playback at a later time, or whether the data are being sent directly back to Earth via a real-time radio link. More data can be acquired during orbits with real-time downlink.

During real-time orbits, the MOC team often will take a few random or semi-random pictures in between the carefully-selected, hand-targeted images. On rare occasions, one of these random pictures will surprise the MOC team. The picture shown here is an excellent example, because the high resolution view (top) is centered so nicely on a trough and an adjacent, shallow crater that it is as if someone very carefully selected the target for MOC. The high-resolution view covers an area only 1.1 km (0.7 mi) wide by 2.3 km (1.4 mi) long. Hitting a target such as this with such a small image is very difficult to do, on purpose, because there are small uncertainties in the predicted orbit, the maps used to select targets, and the minor adjustments of spacecraft pointing at any given moment. Nevertheless, a very impressive image was received.

The high resolution view crosses one of the troughs of the Sirenum Fossae near 31.2oS, 152.3oW. The context image (above) was acquired at the same time as the high resolution view on July 23, 2000. The small white box shows the location of the high resolution picture. The lines running diagonally across the context image from upper right toward lower left are the Sirenum Fossae troughs, formed by faults that are radial to the volcanic region of Tharsis. Both pictures are illuminated from the upper left. The scene shows part of the martian southern hemisphere nearly autumn.

Are Vancomycin Trough Concentrations Adequate for Optimal Dosing?

PubMed Central

Youn, Gilmer; Jones, Brenda; Jelliffe, Roger W.; Drusano, George L.; Rodvold, Keith A.; Lodise, Thomas P.

2014-01-01

The current vancomycin therapeutic guidelines recommend the use of only trough concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both vancomycin efficacy and toxicity are likely to be related to the area under the plasma concentration-time curve (AUC). We assembled richly sampled vancomycin pharmacokinetic data from three studies comprising 47 adults with various levels of renal function. With Pmetrics, the nonparametric population modeling package for R, we compared AUCs estimated from models derived from trough-only and peak-trough depleted versions of the full data set and characterized the relationship between the vancomycin trough concentration and AUC. The trough-only and peak-trough depleted data sets underestimated the true AUCs compared to the full model by a mean (95% confidence interval) of 23% (11 to 33%; P = 0.0001) and 14% (7 to 19%; P < 0.0001), respectively. In contrast, using the full model as a Bayesian prior with trough-only data allowed 97% (93 to 102%; P = 0.23) accurate AUC estimation. On the basis of 5,000 profiles simulated from the full model, among adults with normal renal function and a therapeutic AUC of ≥400 mg · h/liter for an organism for which the vancomycin MIC is 1 mg/liter, approximately 60% are expected to have a trough concentration below the suggested minimum target of 15 mg/liter for serious infections, which could result in needlessly increased doses and a risk of toxicity. Our data indicate that adjustment of vancomycin doses on the basis of trough concentrations without a Bayesian tool results in poor achievement of maximally safe and effective drug exposures in plasma and that many adults can have an adequate vancomycin AUC with a trough concentration of <15 mg/liter. PMID:24165176

Continental rupture and the creation of new crust in the Salton Trough rift, Southern California and northern Mexico: Results from the Salton Seismic Imaging Project

NASA Astrophysics Data System (ADS)

Han, Liang; Hole, John A.; Stock, Joann M.; Fuis, Gary S.; Kell, Annie; Driscoll, Neal W.; Kent, Graham M.; Harding, Alistair J.; Rymer, Michael J.; González-Fernández, Antonio; Lázaro-Mancilla, Octavio

2016-10-01

A refraction and wide-angle reflection seismic profile along the axis of the Salton Trough, California and Mexico, was analyzed to constrain crustal and upper mantle seismic velocity structure during active continental rifting. From the northern Salton Sea to the southern Imperial Valley, the crust is 17-18 km thick and approximately one-dimensional. The transition at depth from Colorado River sediment to underlying crystalline rock is gradual and is not a depositional surface. The crystalline rock from 3 to 8 km depth is interpreted as sediment metamorphosed by high heat flow. Deeper felsic crystalline rock could be stretched preexisting crust or higher-grade metamorphosed sediment. The lower crust below 12 km depth is interpreted to be gabbro emplaced by rift-related magmatic intrusion by underplating. Low upper mantle velocity indicates high temperature and partial melting. Under the Coachella Valley, sediment thins to the north and the underlying crystalline rock is interpreted as granitic basement. Mafic rock does not exist at 12-18 km depth as it does to the south, and a weak reflection suggests Moho at 28 km depth. Structure in adjacent Mexico has slower midcrustal velocity, and rocks with mantle velocity must be much deeper than in the Imperial Valley. Slower velocity and thicker crust in the Coachella and Mexicali valleys define the rift zone between them to be >100 km wide in the direction of plate motion. North American lithosphere in the central Salton Trough has been rifted apart and is being replaced by new crust created by magmatism, sedimentation, and metamorphism.

The Role of Glaciation in Slope Instability of Arctic Trough Mouth Fans: An Example of the NW Barents Sea

NASA Astrophysics Data System (ADS)

Urgeles, R.; Llopart, J.; Lucchi, R.; Rebesco, M.; Brückner, N. W.; Rüther, D. C.; Lantzsch, H.

2017-12-01

Submarine slope instability plays a major role in the development of Arctic Trough Mouth Fans (TMFs). TMFs consist of an alternation of rapidly deposited glacigenic debris flows and a sequence of well-layered plumites and hemipelagic sediments. In this sedimentary context, shallow geophysical data and core samples indicate that there is a specific timing (i.e. shortly after the deglaciation phase) for the occurrence of slope failures. High mean sedimentation rates during glacial maxima of up to 18 kg m-2 yr-1 likely allow excess pore pressure to develop in the water rich plumites and hemipelagic sediments deposited in the previous deglacial period, particularly where such plumites attain a significant thickness. Basin numerical models considering the effect of (1) sediment physical properties, (2) polar margin architecture and (3) ice stream sediment dispersal patterns on resulting stresses, fluid flow and slope failure initiation of the Storfjorden Trough Mouth Fan, NW Barents Sea, show that during glacial maxima, ice streams and rapid accumulation of glacigenic debris flows on the slope induce pore pressure build-up in continental shelf/upper slope sediments. The overpressure developed during glacial maxima remains during the deglacial phase. This overpressure combined with downslope stratification of high water content and low shear strength deglacial/interglacial sediments results in a significant decrease in the factor of safety of the upper slope sediments. The position of the submarine landslides in the stratigraphic record suggest, however, that such excess pore pressure is not enough to trigger the slope failures and indicate that earthquakes related to isostatic rebound are likely involved in the final activation.

Continental rupture and the creation of new crust in the Salton Trough rift, southern California and northern Mexico: Results from the Salton Seismic Imaging Project

USGS Publications Warehouse

Han, Liang; Hole, John A.; Stock, Joann M.; Fuis, Gary S.; Kell, Annie; Driscoll, Neal W.; Kent, Graham M.; Rymer, Michael J.; Gonzalez-Fernandez, Antonio; Aburto-Oropeza, Octavio

2016-01-01

A refraction and wide-angle reflection seismic profile along the axis of the Salton Trough, California and Mexico, was analyzed to constrain crustal and upper mantle seismic velocity structure during active continental rifting. From the northern Salton Sea to the southern Imperial Valley, the crust is 17-18 km thick and approximately one-dimensional. The transition at depth from Colorado River sediment to underlying crystalline rock is gradual and is not a depositional surface. The crystalline rock from ~3 to ~8 km depth is interpreted as sediment metamorphosed by high heat flow. Deeper felsic crystalline rock could be stretched pre-existing crust or higher grade metamorphosed sediment. The lower crust below ~12 km depth is interpreted to be gabbro emplaced by rift-related magmatic intrusion by underplating. Low upper-mantle velocity indicates high temperature and partial melting. Under the Coachella Valley, sediment thins to the north and the underlying crystalline rock is interpreted as granitic basement. Mafic rock does not exist at 12-18 depth as it does to the south, and a weak reflection suggests Moho at ~28 km depth. Structure in adjacent Mexico has slower mid-crustal velocity and rocks with mantle velocity must be much deeper than in the Imperial Valley. Slower velocity and thicker crust in the Coachella and Mexicali valleys define the rift zone between them to be >100 km wide in the direction of plate motion. North American lithosphere in the central Salton Trough has been rifted apart and is being replaced by new crust created by magmatism, sedimentation, and metamorphism.

Drilling constraints on bimodal volcanism and subsequent formation of contrasted uppermost crustal compositions at the middle Okinawa Trough

NASA Astrophysics Data System (ADS)

Yamasaki, T.; Takaya, Y.; Mukae, N.; Nagase, T.; Tindell, T.; Totsuka, S.; Uno, Y.; Yonezu, K.; Nozaki, T.; Ishibashi, J. I.; Kumagai, H.; Maeda, L.; Shipboard Scientist, C.

2016-12-01

The Okinawa Trough (OT) is a young and actively spreading back-arc basin, extending behind the Ryukyu arc-trench system in the southeastern margin of the East China Sea. The OT is believed to be in an initial rifting stage (starting from 6-9 Ma), prior to the normal/stable seafloor spreading which constitutes the main stage of back-arc basin formation. Two drilling cruises ‒ the IODP Exp. 331 and SIP CK14-04 D/V Chikyu Cruise (Exp. 907) in 2010 and 2014 ‒ were conducted at the Iheya North Knoll, middle OT. The Iheya North Knoll is a domal volcanic complex consisting of small volcanic bodies. On these cruises, pumiceous gravel and altered rhyolitic rocks, as well as hemi-pelagic sediments, hydrothermal clay and Kuroko-type ores, were recovered from the upper 200 m of the crust. From Feb. 11, 2016 to Mar. 17, 2016, the SIP CK16-01 (Exp. 908) D/V Chikyu cruise was conducted at Iheya North Knoll and the sediment-covered rifting center of the Iheya-Minor Ridge area, middle OT. The Iheya-Minor ridge area is also an active hydrothermal field, located 25 km southeast of the Iheya North Knoll. In this area, basaltic rocks are widely distributed, and drilling has confirmed that the basaltic materials continue to 120 m below the seafloor. From an igneous petrological point of view, the volcanic rocks in the Okinawa Trough are characterized by bimodal basaltic and rhyolitic compositions, with a compositional gap between SiO2 = 56-66 wt%. The origin of the rhyolitic rock has been interpreted as magmatic differentiation of basaltic magma. However, the existence of an active basalt-hosted hydrothermal field in the Iheya-Minor ridge area suggests the presence of hot basaltic rocks at a shallow position in the crust, and reaching recharged seawater at this depth. Furthermore, the composition of felsic rocks just after the compositional gap (SiO2 = 67 wt%) is very similar to that of the minimum melt of a granitic system, and experimental partial melt of hydrous basalt. Therefore, the contrast in the uppermost crustal composition between very close ( 25 km) areas can reasonably be explained by re-melting of hydrothermally-altered basaltic rocks and production of felsic magma at the upper crustal level, and direct eruption of basaltic magma at the seafloor.

Role of upper-level wind shear on the structure and maintenance of derecho-producing convective systems

NASA Astrophysics Data System (ADS)

Coniglio, Michael Charles

Common large-scale environments associated with the development of derecho-producing convective systems from a large number of events are identified using statistical clustering of the 500-mb geopotential heights as guidance. The majority of the events (72%) fall into three main patterns that include a well-defined upstream trough (40%), a ridge (20%), and a zonal, low-amplitude flow (12%), which is defined as an additional warm-season pattern that is not identified in past studies of derecho environments. Through an analysis of proximity soundings, discrepancies are found in both low-level and deep-tropospheric shear parameters between observations and the shear profiles considered favorable for strong, long-lived convective systems in idealized simulations. To explore the role of upper-level shear in derecho environments, a set of two-dimensional simulations of density currents within a dry, neutrally stable environment are used to examine the ability of a cold pool to lift environmental air within a vertically sheared flow. The results confirm that the addition of upper-level shear to a wind profile with weak to moderate low-level shear increases the vertical displacement of low-level parcels despite a decrease in the vertical velocity along the cold pool interface, as suggested by previous studies. Parcels that are elevated above the surface (1-2 km) overturn and are responsible for the deep lifting in the deep-shear environments. This deep overturning caused by the upper-level shear helps to maintain the tilt of the convective systems in more complex two-dimensional and three dimensional simulations. The overturning also is shown to greatly increase the size of the convective systems in the three-dimensional simulations by facilitating the initiation and maintenance of convective cells along the cold pool. When combined with estimates of the cold pool motion and the storm-relative hodograph, these results may best be used for the prediction of the demise of strong, linear mesoscale convective systems (MCSs) and may provide a conceptual model for the persistence of strong MCSs above a surface nocturnal inversion in situations that are not forced by a low-level jet.

The Impact of AUC-Based Monitoring on Pharmacist-Directed Vancomycin Dose Adjustments in Complicated Methicillin-Resistant Staphylococcus aureus Infection.

PubMed

Stoessel, Andrew M; Hale, Cory M; Seabury, Robert W; Miller, Christopher D; Steele, Jeffrey M

2018-01-01

This study aimed to assess the impact of area under the curve (AUC)-based vancomycin monitoring on pharmacist-initiated dose adjustments after transitioning from a trough-only to an AUC-based monitoring method at our institution. A retrospective cohort study of patients treated with vancomycin for complicated methicillin-resistant Staphylococcus aureus (MRSA) infection between November 2013 and December 2016 was conducted. The frequency of pharmacist-initiated dose adjustments was assessed for patients monitored via trough-only and AUC-based approaches for trough ranges: 10 to 14.9 mg/L and 15 to 20 mg/L. Fifty patients were included: 36 in the trough-based monitoring and 14 in the AUC-based-monitoring group. The vancomycin dose was increased in 71.4% of patients when troughs were 10 to 14.9 mg/L when a trough-only approach was used and in only 25% of patients when using AUC estimation ( P = .048). In the AUC group, the dose was increased only when AUC/minimum inhibitory concentration (MIC) <400; unchanged regimens had an estimated AUC/MIC ≥400. The AUC-based monitoring did not significantly increase the frequency of dose reductions when trough concentrations were 15 to 20 mg/L (AUC: 33.3% vs trough: 4.6%; P = .107). The AUC-based monitoring resulted in fewer patients with dose adjustments when trough levels were 10 to 14.9 mg/L. The AUC-based monitoring has the potential to reduce unnecessary vancomycin exposure and warrants further investigation.

Sequence stratigraphy of the Upper Cambrian (Furongian; Jiangshanian and Sunwaptan) Tunnel City Group, Upper Mississippi Valley: Transgressing assumptions of cratonic flooding

USGS Publications Warehouse

Eoff, Jennifer D.

2014-01-01

New data from detailed measured sections permit comprehensive analysis of the sequence framework of the Furongian (Upper Cambrian; Jiangshanian and Sunwaptan stages) Tunnel City Group (Lone Rock Formation and Mazomanie Formation) of Wisconsin and Minnesota. The sequence-stratigraphic architecture of the lower part of the Sunwaptan Stage at the base of the Tunnel City Group, at the contact between the Wonewoc Formation and Lone Rock Formation, records the first part of complex polyphase flooding (Sauk III) of the Laurentian craton, at a scale smaller than most events recorded by global sea-level curves. Flat-pebble conglomerate and glauconite document transgressive ravinement and development of a condensed section when creation of accommodation exceeded its consumption by sedimentation. Thinly-bedded, fossiliferous sandstone represents the most distal setting during earliest highstand. Subsequent deposition of sandstone characterized by hummocky or trough cross-stratification records progradational pulses of shallower, storm- and wave-dominated environments across the craton before final flooding of Sauk III commenced with carbonate deposition during the middle part of the Sunwaptan Stage. Comparison of early Sunwaptan flooding of the inner Laurentian craton to published interpretations from other parts of North America suggests that Sauk III was not a single, long-term accommodation event as previously proposed.

Climatology of atmospheric circulation patterns of Arabian dust in western Iran.

PubMed

Najafi, Mohammad Saeed; Sarraf, B S; Zarrin, A; Rasouli, A A

2017-08-28

Being in vicinity of vast deserts, the west and southwest of Iran are characterized by high levels of dust events, which have adverse consequences on human health, ecosystems, and environment. Using ground based dataset of dust events in western Iran and NCEP/NCAR reanalysis data, the atmospheric circulation patterns of dust events in the Arabian region and west of Iran are identified. The atmospheric circulation patterns which lead to dust events in the Arabian region and western Iran were classified into two main categories: the Shamal dust events that occurs in warm period of year and the frontal dust events as cold period pattern. In frontal dust events, the western trough or blocking pattern at mid-level leads to frontogenesis, instability, and air uplift at lower levels of troposphere in the southwest of Asia. Non-frontal is other pattern of dust event in the cold period and dust generation are due to the regional circulation systems at the lower level of troposphere. In Shamal wind pattern, the Saudi Arabian anticyclone, Turkmenistan anticyclone, and Zagros thermal low play the key roles in formation of this pattern. Summer and transitional patterns are two sub-categories of summer Shamal wind pattern. In summer trough pattern, the mid-tropospheric trough leads to intensify the surface thermal systems in the Middle East and causes instability and rising of wind speed in the region. In synthetic pattern of Shamal wind and summer trough, dust is created by the impact of a trough in mid-levels of troposphere as well as existing the mentioned regional systems which are contributed in formation of summer Shamal wind pattern.

Association of the clinical efficacy of vancomycin with the novel pharmacokinetic parameter area under the trough level (AUTL) in elderly patients with hospital-acquired pneumonia.

PubMed

Fukumori, S; Tsuji, Y; Mizoguchi, A; Kasai, H; Ishibashi, T; Iwamura, N; To, H

2016-08-01

The pharmacokinetic-pharmacodynamic parameter that best predicts the efficacy of vancomycin is the ratio of the area under the concentration versus time curve (AUC) to the minimum inhibitory concentration (MIC). A 24-h AUC (AUC24 )/MIC ratio ≥ 400 was recommended in an American consensus review, but vancomycin treatment occasionally fails despite maintenance of AUC24 /MIC ≥ 400. We evaluated the association between clinical efficacy of vancomycin and two novel pharmacokinetic parameters, the 'area under the trough level' (AUTL) and the 'area above the trough level' (AATL), in hospitalized elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. The subjects were hospitalized elderly patients who were administered vancomycin for treatment of MRSA pneumonia between 2006 and 2012 at Sasebo Chuo Hospital (Nagasaki, Japan). Pharmacokinetic parameters of vancomycin were estimated for each patient by Bayesian analysis using population pharmacokinetic parameters for Japanese patients. Based on the patient-specific parameters thus obtained, AUC24 values were calculated as the vancomycin dosage divided by vancomycin clearance. AUTL was calculated as the trough serum concentration multiplied by 24 h, whereas AATL was calculated by subtracting AUTL from AUC24 . Logistic regression analysis demonstrated that efficacy of vancomycin was more strongly associated with AUTL than AUC24 . The optimal cut-off value of AUTL was 331 μg∙h/mL, which means that the optimal cut-off value of the trough serum concentration was 13·8 μg/mL. Efficacy of vancomycin was associated with AUTL, a novel pharmacokinetic parameter. Determining the target AUTL or trough concentration may enhance the efficacy of vancomycin therapy in elderly patients with MRSA pneumonia. Given that nephrotoxicity may increase with a Ctrough in excess of 15 μg/mL, this level should ideally not be exceeded. © 2016 John Wiley & Sons Ltd.

Synoptic patterns leading to hailstorm in Chaharmahal and Bakhtiari province, Iran

NASA Astrophysics Data System (ADS)

Salahi, Bromand; Nohegar, Ahmad; Behrouzi, Mahmoud; Aalijahan, Mehdi

2018-03-01

The purpose of this study was to extract the synoptic patterns of 500 mb geopotential height and the sea level pressure leading to form hail in Chaharmahal and Bakhtiari province, Iran. To this end, at first, we explored hail occurrence in different areas of the province under investigation. Then, using sea level pressure and 500 mb geopotential height data, the patterns of hail occurrence were investigated through hierarchical clustering and Ward's method. The level of 500 mb patterns resulting in hail formation in the area include: (1) settlement of a cut-off low pressure blocking in Turkey and Iran's position in downstream of trough and injection of humidity coming from the Red Sea; (2) settlement of low ridge in northern Europe and Iran lying in downstream of the trough and injection of humidity of the Mediterranean Sea; (3) settlement of a cut-off low pressure in east of Europe and Iran lying in downstream of the trough; and (4) settlement of a deep trough in the Mediterranean Sea, formation of an omega-shaped blocking in Northern Europe and Iran lying in downstream of the trough. At sea level, the following patterns have caused hail formation in Chaharmahal and Bakhtiari province: (1) settlement of low pressure in Iran and Russia accompanying high pressure in Taklimakan Desert and east of Europe; (2) settlement of low pressure in Iran and high pressure in Egypt, northern Europe, and Taklimakan Desert; and (3) settlement of low pressure in Iran, Saudi Arabia and south of Italy and high pressure in Egypt and Siberia.

Association Between Low Trough Levels of Vedolizumab During Induction Therapy for Inflammatory Bowel Diseases and Need for Additional Doses Within 6 Months.

PubMed

Williet, Nicolas; Boschetti, Gilles; Fovet, Marion; Di Bernado, Thomas; Claudez, Pierre; Del Tedesco, Emilie; Jarlot, Camille; Rinaldi, Leslie; Berger, Anne; Phelip, Jean-Marc; Flourie, Bernard; Nancey, Stéphane; Paul, Stéphane; Roblin, Xavier

2017-11-01

We investigated whether serum trough levels of vedolizumab, a humanized monoclonal antibody against integrin α4β7, during the induction phase of treatment can determine whether patients will need additional doses (optimization of therapy) within the first 6 months. We conducted an observational study of 47 consecutive patients with Crohn's disease (CD; n = 31) or ulcerative colitis (UC; n = 16) who had not responded to 2 previous treatment regimens with antagonists of tumor necrosis factor and were starting therapy with vedolizumab at 2 hospitals in France, from June 2014 through April 2016. All patients were given a 300-mg infusion of vedolizumab at the start of the study, Week 2, Week 6, and then every 8 weeks; patients were also given corticosteroids during the first 4-6 weeks. Patients not in remission at Week 6 were given additional doses of vedolizumab at Week 10 and then every 4 weeks (extended therapy or optimization). Remission at Week 6 of treatment was defined as CD activity score below 150 points for patients with CD and a partial Mayo Clinic score of <3 points, without concomitant corticosteroids, for patients with UC. Blood samples were collected each week and serum levels of vedolizumab and antibodies against vedolizumab were measured using an enzyme-linked immunosorbent assay. Median trough levels of vedolizumab and interquartile ranges were compared using the nonparametric Mann-Whitney test. The primary objective was to determine whether trough levels of vedolizumab measured during the first 6 weeks of induction therapy associated with the need for extended treatment within the first 6 months. Based on response to therapy at Week 6, extended treatment was required for 30 of the 47 patients (23 patients with CD and 7 patients with UC). At Week 2, trough levels of vedolizumab for patients selected for extended treatment were 23.0 μg/mL (interquartile range, 14.0-37.0 μg/mL), compared with 42.5 μg/mL in patients who did not receive extended treatment (interquartile range, 33.5-50.7; P = .15). At Week 6, trough levels of vedolizumab <18.5 μg/mL were associated with need for extended therapy (100% positive predictive value, 46.2%; negative predictive value; area under the receiver operating characteristic curve, 0.72) within the first 6 months. Among patients who required extended treatment at Week 10, all of those with trough levels of vedolizumab <19.0 μg/mL at Week 6 had achieved clinical remission 4 weeks later (secondary responders). In a prospective study of patients with CD or UC receiving induction therapy with vedolizumab, low trough levels of vedolizumab at Week 6 (<19.0 μg/mL) are associated with need for additional doses (given at Week 10 and then every 4 weeks). All patients receiving these additional doses achieved a clinical response 4 weeks later. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Healthcare-associated Staphylococcus aureus bacteremia in children: Evidence for reverse vancomycin creep and impact of vancomycin trough levels on outcome

PubMed Central

McNeil, J Chase; Kok, Eric Y; Forbes, Andrea; Lamberth, Linda; Hulten, Kristina G; Vallejo, Jesus G; Mason, Edward O; Kaplan, Sheldon L

2015-01-01

Introduction Elevated vancomycin MICs in S. aureus have been associated with worse clinical outcomes in adults. For invasive MRSA infections in adults, the IDSA recommends targeting vancomycin serum trough concentrations between 15–20 μg/ml. We evaluated trends in vancomycin MICs from healthcare-associated S. aureus bacteremia isolates in children in addition to correlating vancomycin serum trough levels with clinical outcomes. Methods Patients and isolates were identified from a prospective S. aureus surveillance study at Texas Children's Hospital (TCH). Healthcare-associated S. aureus bacteremia isolates from 2003–2013 were selected. Vancomycin MICs by E-test were determined and medical records were reviewed. Acute kidney injury (AKI) was defined as doubling of the baseline serum creatinine. Results 341 isolates met inclusion criteria. We observed a reverse vancomycin creep among MRSA isolates in the study period with a decline in the proportion of isolates with vancomycin MIC ≥ 2 μg/ml (from 32.7% to 5.6%, p<0.001). However, the proportion of MSSA isolates with MIC ≥ 2 μg/ml increased (from 2.9% to 9%, p=0.04). Among patients who had vancomycin troughs performed, there was no difference in duration of bacteremia or fever with vancomycin trough >15 μg/ml vs. < 15 μg/ml. A vancomycin trough > 15 μg/ml was, however, an independent risk factor for AKI. Conclusions Vancomycin MICs are shifting among healthcare-associated S. aureus bacteremia isolates with significant differences between MRSA and MSSA at TCH. Higher vancomycin troughs did not improve outcomes in pediatric healthcare-associated S. aureus bacteremia but were associated with increased nephrotoxicity. Further studies are needed to better understand optimal management of children with S. aureus bacteremia. PMID:26646549

Simultaneous Sea-Level Oscillations in Japanese Bays Induced by the Tsunami of Nankai-Trough Earthquake

NASA Astrophysics Data System (ADS)

Oishi, Y.; Furumura, T.; Imamura, F.; Yamashita, K.; Sugawara, D.

2016-12-01

In this study, we investigate the response of bays to the tsunami of Nankai-trough earthquake based on tsunami simulations and demonstrate the possibility that sea-level oscillation of each bay, which is induced by an incident tsunami, interacts with those of other bays. Several major cities in Japan, including the capital, are located in the bays near the Nankai trough and it is assumed that these cities will be largely affected by the tsunamis caused by recurring large earthquakes at the trough. Therefore, it is very important for these populated cities to understand the mechanism and properties of the tsunami-induced oscillations that continue for a long time in bays to draw up evacuation plans. To investigate the response of bays for various tsunamis that may occur in the Nankai trough area, we distributed the tsunami sources that have the form of a 2-D Gaussian function around the Nankai trough. From simulations with these sources, it was found that strong oscillations of bay water occur when the source is located in the bay itself or when strong oscillations occur in other bays. For example, when the Tosa bay oscillates, the Tokyo bay that is 600 km away from the Tosa bay also oscillates. Among the bays around the Nankai trough, the Suruga bay, the deepest bay in Japan with a 2500-km depth, oscillates more strongly than other bays for most cases. To check the influence of the strong oscillations in the Suruga bay on other bays, we conducted tsunami simulations using a modified topography model in which the Suruga bay is artificially landfilled. As a consequence, the strength of oscillations in the adjacent bays are reduced by 20-30%, suggesting the large influence of the distinguished oscillation of the Suruga bay on these bays. We finally conducted tsunami simulations using the eleven Nankai-trough earthquake scenarios of the Central Disaster Prevention Council (CDPC) of Japan as tsunami sources, and the mutual relation regarding the strengths of oscillations among the bays around the Nankai trough was confirmed irrespective of the earthquake scenarios. The results of this study suggest that oscillations of the bays do not occur independently in each bay but simultaneously occur among the bays. More detailed characteristics of the response of the bays to the tsunamis in the Nankai-trough area will be discussed in the presentation.

Characterization of Metabolically Active Bacterial Populations in Subseafloor Nankai Trough Sediments above, within, and below the Sulfate–Methane Transition Zone

PubMed Central

Mills, Heath J.; Reese, Brandi Kiel; Shepard, Alicia K.; Riedinger, Natascha; Dowd, Scot E.; Morono, Yuki; Inagaki, Fumio

2012-01-01

A remarkable number of microbial cells have been enumerated within subseafloor sediments, suggesting a biological impact on geochemical processes in the subseafloor habitat. However, the metabolically active fraction of these populations is largely uncharacterized. In this study, an RNA-based molecular approach was used to determine the diversity and community structure of metabolically active bacterial populations in the upper sedimentary formation of the Nankai Trough seismogenic zone. Samples used in this study were collected from the slope apron sediment overlying the accretionary prism at Site C0004 during the Integrated Ocean Drilling Program Expedition 316. The sediments represented microbial habitats above, within, and below the sulfate–methane transition zone (SMTZ), which was observed approximately 20 m below the seafloor (mbsf). Small subunit ribosomal RNA were extracted, quantified, amplified, and sequenced using high-throughput 454 pyrosequencing, indicating the occurrence of metabolically active bacterial populations to a depth of 57 mbsf. Transcript abundance and bacterial diversity decreased with increasing depth. The two communities below the SMTZ were similar at the phylum level, however only a 24% overlap was observed at the genus level. Active bacterial community composition was not confined to geochemically predicted redox stratification despite the deepest sample being more than 50 m below the oxic/anoxic interface. Genus-level classification suggested that the metabolically active subseafloor bacterial populations had similarities to previously cultured organisms. This allowed predictions of physiological potential, expanding understanding of the subseafloor microbial ecosystem. Unique community structures suggest very diverse active populations compared to previous DNA-based diversity estimates, providing more support for enhancing community characterizations using more advanced sequencing techniques. PMID:22485111

NCAR CCM2 simulation of the modern Antarctic climate

NASA Technical Reports Server (NTRS)

Tzeng, Ren-Yow; Bromwich, David H.; Parish, Thomas R.; Chen, Biao

1994-01-01

The National Center for Atmospheric Research (NCAR) community climate model version 2 (CCM2) simulation of the circumpolar trough, surface air temperature, the polar vortex, cloudiness, winds, and atmospheric moisture and energy budgets are examined to validate the model's representation of the present-day Antarctic climate. The results show that the CCM2 can well simulate many important climate features over Antarctica, such as the location and intensity of the circumpolar trough, the coreless winter over the plateau, the intensity and horizontal distribution of the surface inversion, the speed and streamline pattern of the katabatic winds, the double jet stream feature over the southern Indian and Pacific oceans, and the arid climate over the continent. However, there are also some serious errors in the model. Some are due to old problems but some are caused by the new parameterizations in the model. The model errors over high southern latitudes can be summarized as follows: The circumpolar trough, the polar vertex, and the westerlies in midlatitudes are too strong; the semiannual cycle of the circumpolar trough is distorted compared to the observations; the low centers of the circumpolar trough and the troughs in the middle and upper troposphere are shifted eastward by 15 deg - 40 deg longitude; the surface temperatures are too cold over the plateau in summer and over the coastline in winter; the polar tropopause continues to have a cold bias; and the cloudiness is too high over the continent. These biases are induced by two major factors: (1) the cloud optical properties in tropical and middle latitudes, which cause the eastward shift of troughs and surface low centers and the error in the semiannual cycle, and (2) the cold bias of the surface air temperature, which is attributed to the oversimulation of cloudiness over the continent, especially during summer, and the uniform 2-m-thick sea ice. The constant thickness of sea ice suppresses the energy flux from the ocean to the atmosphere and hence reduces the air temperature near the coast during winter. Finally, although the simulated Antarctic climate still suffers these biases, the overall performance of the CCM2 is much better than that of the CCM1-T42. Therefore the CCM2 is good enough to be used for climate change studies, especially over Antarctica.

Anti-adalimumab antibodies in juvenile idiopathic arthritis-related uveitis.

PubMed

Leinonen, Sanna T; Aalto, Kristiina; Kotaniemi, Kaisu M; Kivelä, Tero T

2017-01-01

To evaluate the association of adalimumab trough levels and anti-adalimumab antibodies with activity of uveitis in juvenile idiopathic arthritis-related uveitis. This was a retrospective observational case series in a clinical setting at the Department of Ophthalmology, Helsinki University Hospital, Finland in 2014-2016. Thirty-one paediatric patients with chronic anterior juvenile idiopathic arthritis-related uveitis in 58 eyes and who had been on adalimumab ≥6 months were eligible for the study. Uveitis activity during adalimumab treatment, adalimumab trough levels and anti-adalimumab antibody levels were recorded. Anti-adalimumab antibody levels ≥12 AU /ml were detected in nine patients (29%). This level of anti-adalimumab antibodies was associated with a higher grade of uveitis (p<0.001), uveitis that was not in remission (p=0.001) and with lack of concomitant methotrexate therapy (p=0.043). In patients with anti-adalimumab antibody levels <12 AU/ml, higher serum trough levels did not associate with better control of uveitis (p=0.86). Adalimumab treatment might be better guided by monitoring anti-adalimumab antibody formation in treating JIA-related uveitis.

Large-Scale Meteorological Patterns Associated with Extreme Precipitation in the US Northeast

NASA Astrophysics Data System (ADS)

Agel, L. A.; Barlow, M. A.

2016-12-01

Patterns of daily large-scale circulation associated with Northeast US extreme precipitation are identified using both k-means clustering (KMC) and Self-Organizing Maps (SOM) applied to tropopause height. Tropopause height provides a compact representation of large-scale circulation patterns, as it is linked to mid-level circulation, low-level thermal contrasts and low-level diabatic heating. Extreme precipitation is defined as the top 1% of daily wet-day observations at 35 Northeast stations, 1979-2008. KMC is applied on extreme precipitation days only, while the SOM algorithm is applied to all days in order to place the extreme results into a larger context. Six tropopause patterns are identified on extreme days: a summertime tropopause ridge, a summertime shallow trough/ridge, a summertime shallow eastern US trough, a deeper wintertime eastern US trough, and two versions of a deep cold-weather trough located across the east-central US. Thirty SOM patterns for all days are identified. Results for all days show that 6 SOM patterns account for almost half of the extreme days, although extreme precipitation occurs in all SOM patterns. The same SOM patterns associated with extreme precipitation also routinely produce non-extreme precipitation; however, on extreme precipitation days the troughs, on average, are deeper and the downstream ridges more pronounced. Analysis of other fields associated with the large-scale patterns show various degrees of anomalously strong upward motion during, and moisture transport preceding, extreme precipitation events.

Arsinoes Chaos Landforms

NASA Technical Reports Server (NTRS)

2004-01-01

23 October 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows light-toned rock outcrops, possibly sedimentary rocks, in the Arsinoes Chaos region east of the Valles Marineris trough system. These rocky materials were once below the martian surface. These features are located near 7.2oS, 27.9oW. The image covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the upper left.

Distribution of Upper Circumpolar Deep Water on the warming continental shelf of the West Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Couto, Nicole; Martinson, Douglas G.; Kohut, Josh; Schofield, Oscar

2017-07-01

We use autonomous underwater vehicles to characterize the spatial distribution of Upper Circumpolar Deep Water (UCDW) on the continental shelf of the West Antarctic Peninsula (WAP) and present the first near-synoptic measurements of mesoscale features (eddies) containing UCDW on the WAP. Thirty-three subsurface eddies with widths on the order of 10 km were detected during four glider deployments. Each eddy contributed an average of 5.8 × 1016 J to the subpycnocline waters, where a cross-shelf heat flux of 1.37 × 1019 J yr-1 is required to balance the diffusive loss of heat to overlying winter water and to the near-coastal waters. Approximately two-thirds of the heat coming onto the shelf diffuses across the pycnocline and one-third diffuses to the coastal waters; long-term warming of the subpycnocline waters is a small residual of this balance. Sixty percent of the profiles that contained UCDW were part of a coherent eddy. Between 20% and 53% of the lateral onshore heat flux to the WAP can be attributed to eddies entering Marguerite Trough, a feature in the southern part of the shelf which is known to be an important conduit for UCDW. A northern trough is identified as additional important location for eddy intrusion.

Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections Caused by Coagulase-Negative Staphylococci.

PubMed

Gibson, Ashley; Kaplan, Sheldon L; Vallejo, Jesus G

2018-04-26

Coagulase-negative staphylococci (CoNS) are a common cause of pediatric ventricular shunt infections. The Infectious Diseases Society of America recommends vancomycin serum troughs of 15-20 µg/mL when treating CoNS shunt infections in adult patients. We report a series of pediatric cases of CoNS shunt infections in which clinical cure was obtained with troughs < 15 µg/mL. These findings question the relevance of this recommendation in pediatric patients. © 2018 S. Karger AG, Basel.

Regional Differences in Stratospheric Intrusions over the USA Investigated using the NASA MERRA-2 Reanalysis

NASA Astrophysics Data System (ADS)

Knowland, K. E.; Ott, L.; Hodges, K.; Wargan, K.; Duncan, B. N.

2016-12-01

Stratospheric intrusions (SI) - the introduction of ozone-rich stratospheric air into the troposphere - have been linked with surface ozone air quality exceedences, especially at the high elevations in the western USA in springtime. However, the impact of SIs in the remaining seasons and over the rest of the USA is less clear. This study investigates the atmospheric dynamics that generate SIs over the western USA and the different mechanisms through which SIs may influence atmospheric chemistry and surface air quality over the eastern USA. An analysis of the spatiotemporal variability of SIs over the continental US is performed using NASA's Modern-Era Retrospective Analysis for Research and Applications Version-2 (MERRA-2) reanalysis dataset and other Goddard Earth Observing System Model, Version 5 (GEOS-5) model products. Both upper-level and lower-level dynamical features are examined on seasonal timescales using the tracking algorithm of Hodges (1995, 1999). We show how upper-level relative vorticity maxima - representing troughs and cut-off lows - can be tracked and related to the lower-level storm tracks. The influence of both sets of tracks on the assimilated MERRA-2 ozone and meteorological parameters throughout the troposphere and lower stratosphere is quantified. By focusing on the major modes of variability that influence the weather patterns in the USA, namely the Pacific North American (PNA) pattern, Arctic Oscillation (AO) and the North Atlantic Oscillation (NAO), predicative patterns in the meteorological fields that are associated with SIs are identified for their regional effects.

Faulting and instability of shelf sediments: eastern Gulf of Alaska

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, P.R.; Molnia, B.F.

1976-04-01

Faults and submarine slides or slumps are potential environmental hazards on the outer continental shelf of the northern Gulf of Alaska. Submarine slides or slumps have been found in two places in the OCS region: (1) seaward of the Malaspina Glacier and Icy Bay, an area of 1770 square kilometers, that has a slope of less than one-half degree, and (2) across the entire span of the Copper River prodelta, an area of 1730 square kilometers, that has a slope of about one-half degree. Seismic profiles across these areas show disrupted reflectors and irregular topography commonly associated with submarine slidesmore » or slumps. Other potential slide or slum areas have been delineated in areas of thick sediment accumulation and relatively steep slopes. These areas include Kayak Trough, parts of Hinchinbrook Entrance and Sea Valley, parts of the outer shelf and upper slope between Kayak Island and Yakutat Bay and Bering Trough.« less

Evidence to Support Monitoring of Vedolizumab Trough Concentrations in Patients With Inflammatory Bowel Diseases.

PubMed

Dreesen, Erwin; Verstockt, Bram; Bian, Sumin; de Bruyn, Magali; Compernolle, Griet; Tops, Sophie; Noman, Maja; Van Assche, Gert; Ferrante, Marc; Gils, Ann; Vermeire, Séverine

2018-04-25

Trough concentrations of vedolizumab were found to correlate with clinical response in phase 3 studies of patients with ulcerative colitis (UC) or Crohn's disease (CD). Nevertheless, there are no solid data to support monitoring of vedolizumab trough concentrations in treated patients. We investigated the correlation between vedolizumab exposure and response in a real-world population and aimed to identify patient factors that affect exposure and response. We performed a retrospective cohort study of 179 consecutive patients (66 with UC and 113 with CD) who began vedolizumab therapy from September 1, 2015, through October 1, 2016, at University Hospitals Leuven, Belgium. Serum concentrations of vedolizumab were measured before all infusions up to week 30. Effectiveness endpoints included endoscopic healing (UC, Mayo endoscopic sub-score ≤1; CD, absence of ulcers), clinical response (physicians' global assessment), and biologic response or remission (based on level of C-reactive protein) and were assessed at week 14 (for patients with UC) and week 22 (for patients with CD). A stepwise forward addition-backward elimination modeling approach was performed to identify factors independently associated with vedolizumab exposure and response. Vedolizumab trough concentrations >30.0 μg/mL at week 2, >24.0 μg/mL at week 6, and >14.0 μg/mL during maintenance therapy associated with a higher probability of attaining the effectiveness endpoints for patients with UC or CD (P < .05). Higher body mass and more severe disease (based on high level of C-reactive protein and low level of albumin and/or hemoglobin) at the start of vedolizumab therapy associated with lower trough concentrations of vedolizumab over the 30-week period and a lower probability of achieving mucosal healing (P < .05). Mucosal healing was achieved in significantly more patients with UC than patients with CD, even though a diagnosis of UC was not an independent predictor of higher vedolizumab trough concentrations. In a retrospective study of 179 patients with CD or UC, we observed a correlation between vedolizumab exposure and response. These findings support monitoring of vedolizumab trough concentrations to predict patients' outcome. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

Observation of two coupled Faraday waves in a vertically vibrating Hele-Shaw cell with one of them oscillating horizontally

NASA Astrophysics Data System (ADS)

Li, Xiaochen; Li, Xiaoming; Liao, Shijun

2018-01-01

A system of two coupled Faraday waves is experimentally observed at the two interfaces of the three layers of fluids (air, pure ethanol, and silicon oil) in a covered Hele-Shaw cell with periodic vertical vibration. Both the upper and lower Faraday waves are subharmonic, but they coexist in different forms: the upper one vibrates vertically, while the crests of the lower one oscillate horizontally with unchanged wave height, and the troughs of the lower one usually remain in the same place (relative to the basin). Besides, they are strongly coupled: the wave height of the lower Faraday waves is either a linear function (when forcing frequency is fixed) or a parabolic function (when acceleration amplitude is fixed) of that of the upper one with a same wavelength.

Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact

PubMed Central

Valerio, Maricela; Muñoz, Patricia; Alcalá, Luis; García-González, Xandra; Burillo, Almudena; Sanjurjo, María; Grau, Santiago

2017-01-01

ABSTRACT Linezolid serum trough (Cmin) and peak (Cmax) levels were determined prospectively in 90 patients. Adequate exposure was defined as a Cmin of 2 to 8 mg/liter. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid Cmin levels was recorded (0.1 to 25.2 μg/ml). Overall, 65.5% of the patients had out-of-range, 41.1% had subtherapeutic, and 24.4% had supratherapeutic trough levels. We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome. PMID:28739788

Small-scale convection beneath the transverse ranges, California: Implications for interpretation of gravity anomalies

NASA Technical Reports Server (NTRS)

Humphreys, E. D.; Hager, B. H.

1985-01-01

Tomographic inversion of upper mantle P wave velocity heterogeneities beneath southern California shows two prominent features: an east-west trending curtain of high velocity material (up to 3% fast) in the upper 250 km beneath the Transverse Ranges and a region of low velocity material (up to 4% slow) in the 100 km beneath the Salton Trough. These seismic velocity anomalies were interpreted as due to small scale convection in the mantle. Using this hypothesis and assuming that temperature and density anomalies are linearly related to seismic velocity anomalies through standard coefficients of proportionality, leads to inferred variations of approx. + or - 300 C and approx. + or - 0.03 g/cc.

Intermountain Cyclogenesis: a Climatology and Multiscale Case Studies

NASA Astrophysics Data System (ADS)

Lee, Tiros Peijiun

1995-11-01

A detailed study of Intermountain cyclones over the western United States is conducted through climatological and case studies. An eleven-year (1976-1986) statistical survey shows that the Nevada cyclogenesis is mainly a springtime (March, April) event while a secondary maximum of cyclogenesis frequency is found in November. Nearly 75% of the Nevada cyclogenesis events (177 out of 237 cases) take place under large-scale westerly to southerly flow aloft across the Sierra Nevada Mountains, while 24% of the events (57 out of 237 cases) occur under northwesterly flow aloft. A composite study of these two types of the flow is shown to demonstrate how differences in large-scale topography affect Intermountain cyclogenesis processes. The result from a case study of 9-11 February 1984 reveals that an antecedent Nevada lee trough formed as a result of large-scale southwesterly flow aloft interacting with the underlying terrain well before the surface and upper-level troughs moved onshore. Subsequent cyclogenesis took place in situ with the axis of the trough as the center of large-scale quasi-geostrophic ascent/positive potential vorticity advection began to spread across the Sierra Nevada Mountains. As the cyclone moved downstream, it was observed to weaken well before reaching the Continental Divide while a new cyclonic development occurred east of the Rocky Mountains. It is shown that the weakening of the Intermountain cyclone was associated with the ongoing interaction between the Intermountain cyclone and large-scale topography and the progressive outrunning of the large-scale dynamical forcing aloft away from the surface cyclone center. An investigation of the large-scale evolution for the 26-29 January 1980 case, which developed beneath the northwesterly flow aloft, further reveals that the underlying topography plays two major roles in contributing to the initial cyclogenesis: (1) to block and to retard cold, stable air east of the Continental Divide from rushing into the Great Basin region, and (2) to produce differential pressure falls across the Sierra Nevada Mountains (more along the eastern slopes) in response to increasing cross -mountain flow. Numerous transient shortwaves in the midtroposphere rapidly move across the GB and the Rocky Mountains into the Plains States, while the Intermountain cyclone moves slower than to the disturbances aloft. There is no downstream lee trough/cyclogenesis to the east of the Rockies during the investigation period since the leeside is characterized by cold, stable air. The third case study is made of an 11-14 December 1987 Intermountain cyclogenesis case which took place in an area of relatively warm and less stable environment near the Arizona-New Mexico border beneath northwesterly flow aloft. The ensuing interaction between the large -scale flow and underlying terrain allowed the surface cyclone to remain quasi-stationary for its entire 36 h life span. We also document a cold-season small-scale Catalina eddy development in the coastal southern California waters in this case. The eddy formed as the equatorward and northeasterly flow upstream of the coastal (San Rafael and Saint Ynez) mountains increased in the lower troposphere. Weak large-scale ascent in the mid- and upper-troposphere over the incipient eddy environment provided evidence of the orographic nature of the small -scale cyclone. The eddy was eventually displaced seaward and weakened with the arrival of powerful large-scale subsidence and increasing northeasterly downslope flow at the lower levels that reached the coastal waters.

Meteorological and operational aspects of 46 clear air turbulent sampling missions with an instrumented B-57B aircraft. Volume 2, appendix C: Turbulence missions

NASA Technical Reports Server (NTRS)

Waco, D. E.

1979-01-01

The results of 46 clear air turbulence (CAT) probing missions conducted with an extensively instrumented B-57B aircraft are summarized from a meteorological viewpoint in a two-volume technical memorandum. The missions were part of the NASA Langley Research Center's MAT (Measurement of Atmospheric Turbulence) program, which was conducted between March 1974, and September 1975, at altitudes ranging up to 15 km. Turbulence samples were obtained under diverse conditions including mountain waves, jet streams, upper level fronts and troughs, and low altitude mechanical and thermal turbulence. CAT was encountered on 20 flights comprising 77 data runs. In all, approximately 4335 km were flown in light turbulence, 1415 km in moderate turbulence, and 255 km in severe turbulence during the program.

Landslide in Coprates

NASA Technical Reports Server (NTRS)

2004-01-01

15 November 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the distal (far) end of a landslide deposit in Coprates Chasma, part of the vast Valles Marineris trough system. Large boulders, the size of buildings, occur on the landslide surface. This October 2004 picture is located near 15.3oS, 54.6oW, and covers an area approximately 3 km (1.9 mi) across. Sunlight illuminates the scene from the upper left.

The Community-based Whole Magnetosphere Model

DTIC Science & Technology

2011-11-15

magnetosphere to the IE module. These are used to specify the aurora. • Incorporated MSIS [Hedin, 1987] and IRI [Bil- itza, 2001] as empirical models...can actually be run utilizing MSIS and IRI at every time step, so they can be coupled like an upper atmosphere module. • Coupled the multifluid...J. L., and Gallagher, D. L.: Forma - tion of density troughs embedded in the outer plas- masphere by subauroral ion drift events, J. Geophys. Res., 102

Lithospheric Structure and Active Deformation in the Salton Trough from Coseismic and Postseismic Models of the 2010 Mw 7.2 El Mayor-Cucapah Earthquake

NASA Astrophysics Data System (ADS)

Fielding, E. J.; Huang, M. H.; Dickinson, H.; Freed, A. M.; Burgmann, R.; Gonzalez-Ortega, J. A.; Andronicos, C.

2016-12-01

The 4 April 2010 Mw 7.2 El Mayor-Cucapah (EMC) Earthquake ruptured about 120 km along several NW-striking faults to the west of the Cerro Prieto Fault in the Salton Trough of Baja California, Mexico. We analyzed interferometric synthetic aperture radar (SAR), SAR and optical pixel offsets, and continuous and campaign GPS data to optimize an EMC coseismic rupture model with 9 fault segments, which fits the complex structure of the faults. Coseismic slip inversion with a layered elastic model shows that largely right-lateral slip is confined to upper 10 km with strong variations along strike. Near-field GPS measures slip on a north-striking normal fault that ruptured at the beginning of the earthquake, previously inferred from seismic waveforms. EMC Earthquake postseismic deformation shows the Earth's response to the large coseismic stress changes. InSAR shows rapid shallow afterslip at the north and south ends of the main ruptures. Continuous GPS from the Plate Boundary Observatory operated by UNAVCO measures the first six years of postseismic deformation, extremely rapid near the rupture. Afterslip on faults beneath the coseismic rupture cannot explain far-field displacements that are best explained by viscoelastic relaxation of the lower crust and upper mantle. We built a viscoelastic 3D finite element model of the lithosphere and asthenosphere based on available data for the region with the EMC coseismic faults embedded inside. Coseismic slip was imposed on the model, allowed to relax for 5 years, and then compared to the observed surface deformation. Systematic exploration of the viscoelastic parameters shows that horizontal and vertical heterogeneity is required to fit the postseismic deformation. Our preferred viscoelastic model has weaker viscosity layers beneath the Salton Trough than adjacent blocks that are consistent with the inferred differences in the geotherms. Defining mechanical lithosphere as rocks that have viscosities greater than 10^19 Pa s (able to sustain stresses for more than 100 years), we infer the thickness of lithosphere beneath the Salton Trough to be 32 km and 65 km beneath the Peninsula Ranges to the west. These mechanical lithosphere-asthenosphere boundaries (LABs) are shallower than the observed seismic LABs, but probably better represent the strength of the blocks in this area.

Role of CYP24A1, VDR and GC gene polymorphisms on deferasirox pharmacokinetics and clinical outcomes.

PubMed

Allegra, S; Cusato, J; De Francia, S; Arduino, A; Longo, F; Pirro, E; Massano, D; De Nicolò, A; Piga, A; D'Avolio, A

2018-05-22

β-Thalassemia patients develop deficiency in vitamin D absorption and liver hydroxylation, resulting in extremely low calcitriol levels. We explored the role of single-nucleotide polymorphisms (SNPs) involved in vitamin D metabolism, transport and activity on deferasirox pharmacokinetics and outcomes (effectiveness trough levels (C trough ) and the area under the curve (AUC) cutoffs of 20 μg ml -1 and 360 μg ml -1  h -1 , respectively; nonresponse AUC limit of 250 μg ml -1  h -1 ). Ninety-nine β-thalassemic patients were enrolled. Drug plasma C trough and AUC were measured by the high-performance liquid chromatography system coupled with an ultraviolet determination method. Allelic discrimination for VDR, CYP24A1, CYP27B1 and GC gene SNPs was performed by real-time PCR. CYP24A1 22776 TT significantly influenced C min and negatively predicted it in regression analysis. CYP24A1 3999 CC was associated with C trough and C min and was a negative predictor of T max , whereas CYP24A1 8620 GG seemed to have a role in C trough , AUC, t 1/2 and C min , and was an AUC negative predictor factor. Considering treatment outcome, Cdx2 and GC 1296 were retained in regression analysis as AUC efficacy cutoff negative predictors.

The oceanography and ecology of the Ross Sea.

PubMed

Smith, Walker O; Ainley, David G; Arrigo, Kevin R; Dinniman, Michael S

2014-01-01

The continental shelf of the Ross Sea exhibits substantial variations in physical forcing, ice cover, and biological processes on a variety of time and space scales. Its circulation is characterized by advective inputs from the east and exchanges with off-shelf regions via the troughs along the northern portions. Phytoplankton biomass is greater there than anywhere else in the Antarctic, although nitrate is rarely reduced to levels below 10 μmol L(-1). Overall growth is regulated by irradiance (via ice at the surface and by the depths of the mixed layers) and iron concentrations. Apex predators reach exceptional abundances, and the world's largest colonies of Adélie and emperor penguins are found there. Krill are represented by two species (Euphausia superba near the shelf break and Euphausia crystallorophias throughout the continental shelf region). Equally important and poorly known is the Antarctic silverfish (Pleuragramma antarcticum), which is also consumed by most upper-trophic-level predators. Future changes in the Ross Sea environment will have profound and unpredictable effects on the food web.

The Oceanography and Ecology of the Ross Sea

NASA Astrophysics Data System (ADS)

Smith, Walker O.; Ainley, David G.; Arrigo, Kevin R.; Dinniman, Michael S.

2014-01-01

The continental shelf of the Ross Sea exhibits substantial variations in physical forcing, ice cover, and biological processes on a variety of time and space scales. Its circulation is characterized by advective inputs from the east and exchanges with off-shelf regions via the troughs along the northern portions. Phytoplankton biomass is greater there than anywhere else in the Antarctic, although nitrate is rarely reduced to levels below 10 μmol L-1. Overall growth is regulated by irradiance (via ice at the surface and by the depths of the mixed layers) and iron concentrations. Apex predators reach exceptional abundances, and the world's largest colonies of Adélie and emperor penguins are found there. Krill are represented by two species (Euphausia superba near the shelf break and Euphausia crystallorophias throughout the continental shelf region). Equally important and poorly known is the Antarctic silverfish (Pleuragramma antarcticum), which is also consumed by most upper-trophic-level predators. Future changes in the Ross Sea environment will have profound and unpredictable effects on the food web.

Circumpolar Deep Water transport and current structure at the Amundsen Sea shelf break

NASA Astrophysics Data System (ADS)

Assmann, Karen M.; Wåhlin, Anna K.; Heywood, Karen J.; Jenkins, Adrian; Kim, Tae Wan; Lee, Sang Hoon

2017-04-01

The West Antarctic Ice Sheet has been losing mass at an increasing rate over the past decades. Ocean heat transport to the ice-ocean interface has been identified as an important contributor to this mass loss and the role it plays in ice sheet stability makes it crucial to understand its drivers in order to make accurate future projections of global sea level. While processes closer to the ice-ocean interface modulate this heat transport, its ultimate source is located in the deep basin off the continental shelf as a core of relatively warm, salty water underlying a colder, fresher shallow surface layer. To reach the marine terminating glaciers and the base of floating ice shelves, this warm, salty water mass must cross the bathymetric obstacle of the shelf break. Glacial troughs that intersect the Amundsen shelf break and deepen southwards towards the ice shelf fronts have been shown to play an important role in transporting warm, salty Circumpolar Deep Water (CDW) towards the ice shelves. North of the shelf break, circulation in the Amundsen Sea occupies an intermediate regime between the eastward Antarctic Circumpolar Current that impinges on the shelf break in the Bellingshausen Sea and the westward southern limb of the Ross Gyre that follows the shelf break in the Ross Sea. Hydrographic and mooring observations and numerical model results at the mouth of the central shelf break trough leading to Pine Island and Thwaites Glaciers show a westward wind-driven shelf break current overlying an eastward undercurrent that turns onto the shelf in the trough. It is thought that the existence of the latter feature facilitates the on-shelf transport of CDW. A less clearly defined shelf break depression further west acts as the main pathway for CDW to Dotson and eastern Getz Ice shelves. Model results indicate that a similar eastward undercurrent exists here driving the on-shelf transport of CDW. Two moorings on the upper slope east of the trough entrance show a persistent westward current in the CDW layer. We use hydrographic and ADCP sections to discuss the mechanisms that could be responsible for the formation of this feature and the implications for oceanic heat transport towards the western Amundsen ice shelves.

[Summary of Research on Relationship Between Core Convective Structure and Intensity Change in Tropical Cyclones

NASA Technical Reports Server (NTRS)

2005-01-01

The downshear reformation of Tropical Storm Gabrielle (2001) was investigated using radar reflectivity and lightning data that were nearly continuous in time, as well as frequent aircraft reconnaissance flights. Initially the storm was a marginal tropical storm in an environment with strong 850-200 hPa vertical wind shear of 12-13 meters per second and an approaching upper tropospheric trough. Both the observed outflow and an adiabatic balance model calculation showed that the radial-vertical circulation increased with time as the trough approached. Convection was highly asymmetric, with almost all radar return located in one quadrant left of downshear in the storm. Reconnaissance data show that an intense mesovortex formed downshear of the original center. This vortex was located just south of, rather than within, a strong downshear left lightning outbreak, consistent with tilting of the horizontal vorticity associated with the vertical wind shear. The downshear mesovortex contained a 972 hPa minimum central pressure, 20 hPa lower than minimum pressure in the original vortex just three hours earlier. The mesovortex became the new center of the storm, but weakened somewhat prior to landfall. It is argued that dry air carried around the storm from the region of upshear subsidence, as well as the direct effects of the shear, prevented the reformed vortex from continuing to intensify. Despite the subsequent weakening of the reformed center, it reached land with greater intensity than the original center. It is argued that this intensification process was set into motion by the vertical wind shear in the presence of an environment with upward motion forced by the upper tropospheric trough. In addition, the new center formed much closer to the coast and made landfall much earlier than predicted. Such vertical shear-induced intensity and track fluctuations are important to understand, especially in storms approaching the coast. The structures of the highly sheared tropical storm Chantal During CAMEX-4 is also discussed.

Western Ross Sea continental slope gravity currents

NASA Astrophysics Data System (ADS)

Gordon, Arnold L.; Orsi, Alejandro H.; Muench, Robin; Huber, Bruce A.; Zambianchi, Enrico; Visbeck, Martin

2009-06-01

Antarctic Bottom Water of the world ocean is derived from dense Shelf Water that is carried downslope by gravity currents at specific sites along the Antarctic margins. Data gathered by the AnSlope and CLIMA programs reveal the presence of energetic gravity currents that are formed over the western continental slope of the Ross Sea when High Salinity Shelf Water exits the shelf through Drygalski Trough. Joides Trough, immediately to the east, offers an additional escape route for less saline Shelf Water, while the Glomar Challenger Trough still farther east is a major pathway for export of the once supercooled low-salinity Ice Shelf Water that forms under the Ross Ice Shelf. The Drygalski Trough gravity currents increase in thickness from ˜100 to ˜400 m on proceeding downslope from ˜600 m (the shelf break) to 1200 m (upper slope) sea floor depth, while turning sharply to the west in response to the Coriolis force during their descent. The mean current pathway trends ˜35° downslope from isobaths. Benthic-layer current and thickness are correlated with the bottom water salinity, which exerts the primary control over the benthic-layer density. A 1-year time series of bottom-water current and hydrographic properties obtained on the slope near the 1000 m isobath indicates episodic pulses of Shelf Water export through Drygalski Trough. These cold (<-1 °C), salty (>34.75) pulses correlate with strong downslope bottom flow. Extreme examples occurred during austral summer/fall 2003, comprising concentrated High Salinity Shelf Water (-1.9 °C; 34.79) and approaching 1.5 m s -1 at descent angles as large as ˜60° relative to the isobaths. Such events were most common during November-May, consistent with a northward shift in position of the dense Shelf Water during austral summer. The coldest, saltiest bottom water was measured from mid-April to mid-May 2003. The summer/fall export of High Salinity Shelf Water observed in 2004 was less than that seen in 2003. This difference, if real, may reflect the influence of the large iceberg C-19 over Drygalski Trough until its departure in mid-May 2003, when there was a marked decrease in the coldest, saltiest gravity current adjacent to Drygalski Trough. Northward transport of cold, saline, recently ventilated Antarctic Bottom Water observed in March 2004 off Cape Adare was ˜1.7 Sv, including ˜0.4 Sv of High Salinity Shelf Water.

Comparision between crustal density and velocity variations in Southern California

USGS Publications Warehouse

Langenheim, V.E.; Hauksson, E.

2001-01-01

We predict gravity from a three-dimensional Vp model of the upper crust and compare it to the observed isostatic residual gravity field. In general this comparison shows that the isostatic residual gravity field reflects the density variations in the upper to middle crust. Both data sets show similar density variations for the upper crust in areas such as the Peninsular Ranges and the Los Angeles basin. Both show similar variations across major faults, such as the San Andreas and Garlock faults in the Mojave Desert. The difference between the two data sets in regions such as the Salton Trough, the Eastern California Shear Zone, and the eastern Ventura basin (where depth to Moho is <30 km), however, suggests high-density middle to lower crust beneath these regions. Hence the joint interpretation of these data sets improves the depth constraints of crustal density variations.

Facies mosaic in a fiord: Carboniferous-Permian Talchir Formation, India

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bose, P.K.; Mukhopadhyay, G.; Bhattacharya, H.N.

1988-01-01

Facies analysis of the basal 37m of the Carboniferous-Permian Talchir Formation is a glacier-fed bedrock trough in Dudhi nala, Bihar, India, provides insight into the pattern of sedimentation of course gravels in a fiord. Rapid transitions between 11 recognized facies, together with their complex organization, random variability in bed thickness, and differences in clast, shape, size, and composition indicate coalescence of fans developed from numerous point sources bordering the elongated trough. Converging slide masses and lodgment tillites on the slopes flanking the trough give way to sediment gravity flow deposits composed of an array of conglomerates (matrix and clast supportedmore » with normal, inverse of absence of grading), attendant turbidite sands, and prodelta mud. The rheology of the in-trough flows ranged from plastic laminar to fluidal turbulent in response to flow from slope to floor of the trough. Rapid calving of icebergs during the onset of deglaciation established a wave regime at the mouth of the trough and deposited cross-stratified sandstone replete with dripstones. The impact of large dripstones landing triggered turbidity currents. Continued rise in water level led to eventual preservation of the fan complex under onlapping wave-built shoal facies that grade into a sequence of upward-thinning hummocky cross-stratified sandstone beds virtually devoid of dripstones.« less

The Relationship of Emerita talpoida to Beach Characteristics.

DTIC Science & Technology

1981-05-01

shore toward the step. High density cells frequently lie within areas of reduced wave energy such as cusp troughs. Structures extending across the...relatively con- stant across the beach. The cell of fine sand (0.35 mm) in the upper and middle foreshore immediately north of the pier is a consequence...across the foreshore for approximately 200 meters south and 100 meters north of the pier. Cells of coarse sand are found in the lower foreshore. The 200

Earth observation taken by the Expedition 20 crew

NASA Image and Video Library

2009-07-25

ISS020-E-026195 (25 July 2009) --- Aorounga Impact Crater is featured in this image photographed by an Expedition 20 crew member on the International Space Station. Aorounga Impact Crater is located in the Sahara Desert of north-central Chad and is one of the best preserved impact structures in the world. According to scientists, the crater is thought to be middle or upper Devonian to lower Mississippian (approximately 345 ? 370 million years old) based on the age of the sedimentary rocks deformed by the impact. Spaceborne Imaging Radar (SIR) data collected in 1994 suggests that Aorounga is one of a set of three craters formed by the same impact event. The other two suggested impact structures are buried by sand deposits. The concentric ring structure of the Aorounga crater ? renamed Aorounga South in the multiple-crater interpretation of SIR data ? is clearly visible in this detailed photograph. The central highland, or peak, of the crater is surrounded by a small sand-filled trough; this in turn is surrounded by a larger circular trough. Linear rock ridges alternating with light orange sand deposits cross the image from upper left to lower right; these are called yardangs by geomorphologists. Yardangs form by wind erosion of exposed rock layers in a unidirectional wind field. The wind blows from the northeast at Aorounga, and sand dunes formed between the yardangs are actively migrating to the southwest.

Resurfacing event observed in Morpheos basin (Eridania Planitia) and the implications to the formation and timing of Waikato and Reull Valles, Mars

NASA Astrophysics Data System (ADS)

Kostama, V.-P.; Kukkonen, S.; Raitala, J.

2017-06-01

The large scale outflow channels of the Hellas impact basin are characteristic to its eastern rim region. Although the majority of the valles are located in the large-scale topographic trough connecting Hesperia Planum and Hellas basin, the most far-reaching of them, Reull Vallis is situated to the south-southeast of this trough cutting through Promethei Terra. Reull Vallis and the general geology of the region has been studied in the past, but new higher resolution image data enables us to look into the details of the features implicating the fluvial history of the region. Photogeological mapping using the available data and extensive crater counting utilizing CTX, HiRISE and HRSC provided new insights to the timing of the regional events and episodes. The study resulted in more detailed age constraints compared to the previous results from Viking images. These calculations and the geological study of the upper WMR system (Waikato Vallis - Morpheos basin - Reull Vallis) region and southern Hesperia Planum enabled us to estimate the time-frame of the (fluid) infilling of this reservoir to a model time period of 3.67-3.52 Ga which is thus also the time of the visible activity of the upper Reull Vallis and Waikato Vallis outflow channels. The results also more explicitly defined the size of previously identified Morpheos basin (confined to the 500-550 m contour lines). We also present a geological analysis of the upper parts of the WMR system, and using the observations and calculations, present an updated view of the evolution of the system and associated region.

Evaluation of risk factors for vancomycin-induced nephrotoxicity.

PubMed

Park, So Jin; Lim, Na Ri; Park, Hyo Jung; Yang, Jae Wook; Kim, Min-Ji; Kim, Kyunga; In, Yong Won; Lee, Young Mee

2018-05-09

Background Vancomycin is a glycopeptide antibiotic of choice for the treatment of serious infections caused by multi-resistant Gram-positive bacteria. However, vancomycin-associated nephrotoxicity (VAN) often limits its use. Previous data suggested a few risk factors of VAN, including higher mean vancomycin trough level, higher daily doses, old age, long duration of vancomycin therapy, and concomitant nephrotoxins. Objective To evaluate the incidence and risk factors of VAN and determine whether higher vancomycin trough concentrations were associated with a greater risk for VAN. Settings A retrospective, observational, single-center study at the 1960-bed university-affiliated tertiary care hospital (Samsung Medical Center), Seoul, Korea. Method A retrospective analysis of adult patients who received vancomycin parenterally in a tertiary care medical center from March 1, 2013 to June 30, 2013 was performed. We excluded patients with a baseline serum creatinine level > 2 mg/dL and those who had a history of end-stage renal disease and dialysis at baseline. The clinical characteristics were compared between patients with nephrotoxicity and those without nephrotoxicity to identify the risk factors associated with VAN. Main outcome measure Incidence of VAN and VAN-associated risk factors were analyzed. Results Of the 315 vancomycin-treated patients, nephrotoxicity occurred in 15.2% of the patients. In multivariate analysis, higher vancomycin trough concentrations of > 20 mg∕L (OR 9.57, 95% CI 2.49-36.83, p < 0.01) and intensive care unit (ICU) residence (OR 2.86, 95% CI 1.41-5.82, p < 0.01) were independently associated with VAN. Conclusion Our findings suggest that higher vancomycin trough levels and ICU residence might be associated with a greater risk for VAN. More careful monitoring of vancomycin serum trough levels and patient status might facilitate the timely prevention of VAN.

Case study: A severe hailstorm and strong downbursts over northeastern Slovenia on June 16th 2009

NASA Astrophysics Data System (ADS)

Korosec, M.

2009-09-01

Introduction A strong isolated storm complex with bow echo feature crossed northeastern Slovenia in the late afternoon hours and caused extensive damage due to severe wind gusts near 30m/s, excessive rainfalls and large hail. Synoptic situation On June 16th 2009, an upper-level ridge persists over southern Europe while a positively tilted short-wave trough, connected to a complex deep trough over northern Europe, crosses central Europe. Accompanied by this trough, a cold front is extending southwestwards towards the Alps. A relatively strong jet steak wraps around the trough axis and creates strong shear environment which overlaps with a narrow band of unstable airmass present ahead of the coming frontal boundary. Behind this trough/front over central Europe, a high pressure area is developing with stable conditions. Over Slovenia, strong surface heating was on going through the day but lack of near-surface convergence zones, limited moisture and strong capping inversion surpressed any storm initiation in the afternoon. Presentation of research This case study will go through a research of damaging bow echo which caused extensive damage due to severe winds, excessive rainfalls and large hail over much of northeastern Slovenia. Numerous trees were down or uprooted and numerous roofs were blown off or were seriously damaged due to severe wind gusts near or exceeding 30m/s. At first stages, when an isolated severe storm entered Slovenia, it had classic high precipitation supercell features while it transformed into a powerful bow echo later on. Very large hail up to 6cm in diameter was first observed in southeast Austria and near the border with Slovenia, while later on the main threat was very strong wind gusts and intense rainfalls. This research paper will show a detailed analysis of the synoptic situation including analysis of satellite, radar and surface observations. Radar imagery clearly showed isolated storm trailing along the near-surface frontal boundary as a bow echo and also satellite imagery showed signs of extremely severe storm as overshooting tops, "cold ring" and "U-shape" features were observed. References - Skywarn Austria forum: (http://www.skywarn.at/forum/) - EARS radar and SFC observations archive (http://www.arso.gov.si) - EARS article: Porocilo o neurjih 16. junija 2009 - OSMER FVG (http://www.meteo.fvg.it) - ESSL/ESWD database (www.essl.org) - ESTOFEX convective maps (www.estofex.org) - EUMETSAT satellite imagery (www.eumetsat.int) - 24ur.com/RTVSLO web portal (www.24ur.com, www.rtvslo.si) - Sobota Info web portal (www.sobotainfo.com) - Pomurje web portal (www.pomurje.si) - Administration of the Republic of Slovenia for Civil Protection and Disaster Relief, www.sos112.si - Worldwide Skew-t diagrams (http://weather.uwyo.edu/upperair/europe.html)

Offshore Tectonics of the St. Elias Mountains: Insights from Ocean Drilling and Seismic Stratigraphy on the Yakutat Shelf

NASA Astrophysics Data System (ADS)

Worthington, L. L.; Gulick, S. P. S.; Montelli, A.; Jaeger, J. M.; Zellers, S.; Walczak, M. H.; Mix, A. C.

2015-12-01

Ongoing collision of the Yakutat (YAK) microplate with North America (NA) in southern Alaska has driven orogenesis of the St. Elias Mountains and the advance of the offshore deformation front to the southeast. The offshore St. Elias fold-thrust belt records the complex interaction between collisional tectonics and glacial climate variability, providing insight for models of orogenesis and the evolution of glacial depocenters. Glacial erosion and deposition have provided sediment that constructed the upper continental shelf, much of which has been reincorporated into the orogenic wedge through offshore faulting and folding. We integrate core and downhole logging data from IODP Expedition 341 (Sites U1420 and U1421) drilled on the Yakutat shelf and slope with high-resolution and regional seismic profiles to investigate the coupled structural and stratigraphic evolution of the St. Elias margin. Site U1420 lies on the Yakutat shelf within the Bering Trough, a shelf-crossing trough that is within primary depocenter for Bering Glacier sediments. Two faults underlie the glacial packages and have been rendered inactive as the depositional environment has evolved, while faulting elsewhere on the shelf has initiated. Site U1421 lies on the current continental slope, within the backlimb of an active thrust that forms part of the modern YAK-NA deformation front. At each of these sites, we recovered glacigenic diamict (at depths up to ~1015 m at Site U1420), much of which is younger than 0.3 Ma. Age models within the trough indicated that initiation of active deformation away from the Bering Trough depocenter likely occurred since 0.3 Ma, suggesting that possible tectonic reorganization due to mass redistribution by glacial processes can occur at time scales on the order of 100kyr-1Myr.

Facies analysis, palaeoenvironmental reconstruction and stratigraphic development of the Early Cretaceous sediments (Lower Bima Member) in the Yola Sub-basin, Northern Benue Trough, NE Nigeria

NASA Astrophysics Data System (ADS)

Sarki Yandoka, Babangida M.; Abubakar, M. B.; Abdullah, Wan Hasiah; Amir Hassan, M. H.; Adamu, Bappah U.; Jitong, John S.; Aliyu, Abdulkarim H.; Adegoke, Adebanji Kayode

2014-08-01

The Benue Trough of Nigeria is a major rift basin formed from the tension generated by the separation of African and South American plates in the Early Cretaceous. It is geographically sub-divided into Southern, Central and Northern Benue portions. The Northern Benue Trough comprises two sub-basins; the N-S trending Gongola Sub-basin and the E-W trending Yola Sub-basin. The Bima Formation is the oldest lithogenetic unit occupying the base of the Cretaceous successions in the Northern Benue Trough. It is differentiated into three members; the Lower Bima (B1), the Middle Bima (B2) and the Upper Bima (B3). Facies and their stratigraphical distribution analyses were conducted on the Lower Bima Member exposed mainly at the core of the NE-SW axially trending Lamurde Anticline in the Yola Sub-basin, with an objective to interpret the paleodepositional environments, and to reconstruct the depositional model and the stratigraphical architecture. Ten (10) lithofacies were identified on the basis of lithology, grain size, sedimentary structures and paleocurrent analysis. The facies constitute three (3) major facies associations; the gravelly dominated, the sandy dominated and the fine grain dominated. These facies and facies associations were interpreted and three facies successions were recognized; the alluvial-proximal braided river, the braided river and the lacustrine-marginal lacustrine. The stratigraphic architecture indicates a rifted (?pull-apart) origin as the facies distribution shows a progradational succession from a shallow lacustrine/marginal lacustrine (at the axial part of the basin) to alluvial fan (sediment gravity flow)-proximal braided river (gravel bed braided river) and braided river (channel and overbank) depositional systems. The facies stacking patterns depict sedimentation mainly controlled by allogenic factors of climate and tectonism.

The role of water in the petrogenesis of Marina trough magmas

NASA Astrophysics Data System (ADS)

Stolper, Edward; Newman, Sally

1994-02-01

Most variations in composition among primitive basalts from the Mariana back-arc trough can be explained by melting mixtures of an N-type mid-ocean ridge basalt (NMORB) mantle source and an H2O rich component, provided the degree of melting is positively and approximately linearly correlated with the proportion of the H2O-rich component in the mixture. We conclude that the degrees of melting by which Mariana trough magmas are generated increase from magmas similar to NMORB, through more H2O-enriched basalts, to 'arc-like' basalts, and that this increase is due to the lowering of the solidus of mantle peridotite that accompanies addition of the H2O-rich component. The H2O-rich component is likely to be ultimately derived from fluid from a subducting slab, but we propose that by the time fluids reach the source regions of Mariana trough basalts, they have interacted with sufficient mantle material that for all but the most incompatible of elements (with respect to fluid-mantle interaction), they are in equilibrium with the mantle. In contrast, fluids added to the source regions of Mariana island-arc magmas have typically interacted with less mantle and thus retain the signature of slab-derived fluids to varying degrees for all but the most compatible elements. Primitive Mariana arc basalts can be generated by melting mixtures of such incompletely exchanged slab-derived fluids and sources similar to NMORB-type mantle sources, but the degrees of melting are typically higher than those of Mariana trough NMORB and the sources have been variably depleted relative to the back-arc sources by previous melt extraction. This depletion may be related to earlier extraction of back-arc basin magmas or may evolve by repeated fluxing of the sources as fluid is continually added to them in the regions of arc magma generation. If fluid with partitioning behavior relative to the solid mantle similar to that deduced for the H2O-rich component involved in the generation of Mariana trough basalts were extracted from primitive mantle, the residual mantle would have many of the minor and trace element characteristics of typical oceanic upper mantle; primitive mantle enriched in such fluid would be a satisfactory source for the continental crust in terms of its trace and minor element chemical composition.

Quaternary Turbidite Sedimentation in the Moresby Trough, Preliminary Observations from the Papua New Guinea S2S Study Area

NASA Astrophysics Data System (ADS)

Bentley, S. J.; Muhammad, Z.; Dickens, J.; Droxler, A.; Peterson, L.; Opdyke, B.

2004-12-01

Multicores and jumbo piston cores were collected from the Moresby Trough from the R/V Melville in March-April 204 to study patterns of off-shelf sediment flux from the Gulf of Papua to the deep sea over Pleistocene-Holocene timescales. The Moresby Trough represents the primary deep-sea sediment conduit linking the Source to Sink Gulf of Papua study area to the north with the Coral Sea Basin to the south. Core locations were navigated from the surface using dynamic positioning and multibeam bathymetric mosaics collected during the cruise. Selected cores have been analyzed using a multi-sensor core logger, X-radiography, granulometry, and Pb-210 geochronology. Most piston cores collected from the Moresby Trough contain abundant mafic sandy turbidites overlain by fine-grained hemipelagic deposits 1-2 m thick. X-radiographs of multicores reveal mostly bioturbated hemipelagics. However, one core, MV25-0403-24MC, was collected from the axis of a primary channel, and contains at least two fine-grained turbidites within the upper 0.5 m of sediment. The uppermost turbidite contains low but uniform activities of excess Pb-210, and may have been 15-20 cm thick at the time of deposition (i.e., before subsequent disruption by bioturbation), based on fabric and radiochemical evidence. Application of a simple box-model for physical mixing (i.e., during the flow) and subsequent decay suggests that the uppermost turbidite was deposited 70-120 years before present. Bioturbation has since reworked about 60% of the bed, suggesting that such beds will only escape destruction by bioturbation if they are > 10 cm thick, and are deposited more frequently than once per century. Based on these observations, we suggest that gravity flows are presently active in the Moresby trough, and may account for a significant fraction of the hemipelagic drape present in channel systems. However, fabric evidence for these thin, fine-grained beds may be obscured by subsequent bioturbation. Also, at some point in the past, possibly at the onset of the Holocene Transgression, the character of sediment flux to the Moresby Trough shifted from sandy mafic-rich sandy turbidity currents to much finer sediments, delivered downslope by both benthic flows and vertical flux through the water column.

Examination of the largest-possible tsunamis (Level 2) generated along the Nankai and Suruga troughs during the past 4000 years based on studies of tsunami deposits from the 2011 Tohoku-oki tsunami

NASA Astrophysics Data System (ADS)

Kitamura, Akihisa

2016-12-01

Japanese historical documents reveal that Mw 8 class earthquakes have occurred every 100-150 years along the Suruga and Nankai troughs since the 684 Hakuho earthquake. These earthquakes have commonly caused large tsunamis with wave heights of up to 10 m in the Japanese coastal area along the Suruga and Nankai troughs. From the perspective of tsunami disaster management, these tsunamis are designated as Level 1 tsunamis and are the basis for the design of coastal protection facilities. A Mw 9.0 earthquake (the 2011 Tohoku-oki earthquake) and a mega-tsunami with wave heights of 10-40 m struck the Pacific coast of the northeastern Japanese mainland on 11 March 2011, and far exceeded pre-disaster predictions of wave height. Based on the lessons learned from the 2011 Tohoku-oki earthquake, the Japanese Government predicted the tsunami heights of the largest-possible tsunami (termed a Level 2 tsunami) that could be generated in the Suruga and Nankai troughs. The difference in wave heights between Level 1 and Level 2 tsunamis exceeds 20 m in some areas, including the southern Izu Peninsula. This study reviews the distribution of prehistorical tsunami deposits and tsunami boulders during the past 4000 years, based on previous studies in the coastal area of Shizuoka Prefecture, Japan. The results show that a tsunami deposit dated at 3400-3300 cal BP can be traced between the Shimizu, Shizuoka and Rokken-gawa lowlands, whereas no geologic evidence related to the corresponding tsunami (the Rokken-gawa-Oya tsunami) was found on the southern Izu Peninsula. Thus, the Rokken-gawa-Oya tsunami is not classified as a Level 2 tsunami.

Verification of the modelling of the main ionospheric trough by the Electron Density Assimilative Model (EDAM)

NASA Astrophysics Data System (ADS)

Parker, James; Pryse, Eleri; Jackson-Booth, Natasha

2017-04-01

The main ionospheric trough is a large-scale spatial depletion in the ionospheric electron density that commonly separates the auroral and mid-latitude regions. The feature covers several degrees in latitude and is extended in longitude. It exhibits substantial day-to-day variability in both the location of its minimum ionisation density and in its latitudinal structure. Observations from the UK have shown the trough to be a night-time feature, appearing in early evening to the north of the mainland and progressing equatorward during the course of the night. At dawn, photoionisation fills in the feature. Under increasing levels of geomagnetic activity, the trough moves progressively to lower latitudes. Steep gradients on the trough walls and their variability can cause problems for radio applications. EDAM can be used to model the ionosphere at the trough latitudes by assimilating ionospheric observations from this region into the International Reference Ionosphere (IRI). In this study troughs modelled by EDAM, assimilating data for a period from September to December 2002, are presented and are verified by comparisons with independent observations. Measurements of slant total electron content (sTEC) between GPS satellites and forty ground receivers in Europe were assimilated into EDAM to model the ionospheric electron density. The Vertical Total Electron Content (VTEC) was then calculated through the model, with the values at the longitude of 0.0E considered to obtain statistical characteristics of identified troughs parameters. Comparisons of the parameters with those obtained previously, using transmissions from the satellites of NIMS (Navy Ionospheric Monitoring System) orbiting at altitudes lower than GPS, revealed consistent results. Further support for the EDAM trough was obtained by comparisons of the model with independent GPS measurements. For this a GPS ground station not used in the assimilation was used to observe the sTEC to this "truth" station. Comparisons of these independent truth data with sTEC calculated through the model were used to determine the accuracy of EDAM in the vicinity of the trough.

Patterns of orographic uplift in the Sierra Nevada and their relationship to upper-level atmospheric circulation

USGS Publications Warehouse

Aguado, Edward; Cayan, Daniel R.; Reece, Brian D.; Riddle, Larry

1993-01-01

We examine monthly and seasonal patterns of precipitation across various elevations of the eastern Central Valley of California and the Sierra Nevada. A measure of the strength of the orographic effect called the “precipitation ratio” is calculated, and we separate months into four groups based on being wet or dry and having low or high precipitation ratios. Using monthly maps of mean 700-mb height anomalies, we describe the northern hemisphere mid-tropospheric circulation patterns associated with each of the four groups. Wet months are associated with negative height anomalies over the eastern Pacific, as expected. However, the orientation of the trough is different for years with high and low precipitation ratios. Wet months with high ratios typically have circulation patterns factoring a west-southwest to east-northeast storm track from around the Hawaiian Islands to the Pacific Northwest of the United States. Wet months with low precipitation ratios are associated with a trough centered near the Aleutians and a northwest to southeast storm track. Dry months are marked by anticyclones in the Pacific, but this feature is more localized to the eastern Pacific for months with low precipitation ratios than for those with high ratios. Using precipitation gauge and snow course data from the American River and Truckee-Tahoe basins, we determined that the strength of the orographic effect on a seasonal basis is spatially coherent at low and high elevations and on opposite sides of the Sierra Nevada crestline.

Complex depth-related patterns in taxonomic and functional diversity of polychaetes in the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Carvalho, Russell; Wei, Chih-Lin; Rowe, Gilbert; Schulze, Anja

2013-10-01

Patterns of taxonomic and functional diversity in polychaete assemblages were examined in the deep northern Gulf of Mexico, including the first analysis of polychaete feeding guild distribution. An analysis of samples from a total of 51 stations located along 7 transects plus additional nearby sites, indicated that density decreased exponentially with depth, with the central locations having higher densities than the eastern and western regions. Alpha diversity was also highest at the central stations associated with the Mississippi trough. The samples can be grouped into three significant clusters based on thirty percent similarity of species composition. BIO-ENV indicated depth, sediment particle size, and export POC were most important variables explaining distributions. The diversity of polychaete feeding guilds was high in the Mississippi trough, upper and mid-slope regions but declined to a few guilds on the Sigsbee abyssal plain. Combining feeding guild analysis with traditional analysis of species diversity contributes to a clearer understanding of trophic diversity in deep-sea benthic assemblages.

Inferred rheological structure and mantle conditions from postseismic deformation following the 2010 Mw 7.2 El Mayor-Cucapah Earthquake

NASA Astrophysics Data System (ADS)

Dickinson-Lovell, Haylee; Huang, Mong-Han; Freed, Andrew M.; Fielding, Eric; Bürgmann, Roland; Andronicos, Christopher

2018-06-01

The 2010 Mw7.2 El Mayor-Cucapah earthquake provides a unique target of postseismic study as deformation extends across several distinct geological provinces, including the cold Mesozoic arc crust of the Peninsular Ranges and newly formed, hot, extending lithosphere within the Salton Trough. We use five years of global positioning system measurements to invert for afterslip and constrain a 3-D finite-element model that simulates viscoelastic relaxation. We find that afterslip cannot readily explain far-field displacements (more than 50 km from the epicentre). These displacements are best explained by viscoelastic relaxation of a horizontally and vertically heterogeneous lower crust and upper mantle. Lower viscosities beneath the Salton Trough compared to the Peninsular Ranges and other surrounding regions are consistent with inferred differences in the respective geotherms. Our inferred viscosity structure suggests that the depth of the Lithosphere/Asthenosphere Boundary (LAB) is ˜65 km below the Peninsular Ranges and ˜32 km beneath the Salton Trough. These depths are shallower than the corresponding seismic LAB. This suggests that the onset of partial melting in peridotite may control the depth to the base of the mechanical lithosphere. In contrast, the seismic LAB may correspond to an increase in the partial melt percentage associated with the change from a conductive to an adiabatic geotherm.

Geophysical investigation of an upper tertiary subbasin in the southern Egyptian Red Sea shelf and its bearing on oil exploration

NASA Astrophysics Data System (ADS)

Khattab, M. M.

Several narrow, elongate and Red Sea-trending gravity lows, suggested recently as due to depositional troughs, are shown on the Egyptian Red Sea shelf Bouguer map. Few drilling data and poor reflectivity below the Pliocene-Miocene uncorformity hinder subsurface evaluation. A 1 mgal anomaly (25 km north of Ras Benas Peninsula) was analysed along a crossing sessmic reflection line. The interpretation was aided by: lithology at an off-shore well, seismic data above the unconformity and aeromagnetic data in the southerly-located Foul Bay. The best fit of computed to observed gravity was for a three-layers model (water, post-evaporites and evaporites) where maximum sediment thickness was 3.8 km of which layers 2 and 3 constittted 1.6 and 2.2 km. The subbasin configuration was found to be controlled by Quaternary (similar to that mapped at Egyptian and Saudi Arabian coastal provinces) and pre-middle Miocence (affecting only middle Miocene evaprites beneath a reflection line at the western margin of the main trough near latitude 24°N) faulting which supports the conceot of Red Sea arching and subsequent faulting at marginal shelves. This subbasin is found associated, in part, with a sea--floor trough and with part of Foul Bay magnetic lineations (interpreted recently as caused by oceanic crust) which, in turn, are shown to constitute continuation of mapped onshore tholeiitic dikes.

Broken Plain

NASA Technical Reports Server (NTRS)

2006-01-01

2 February 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows polygonally patterned ground on the floor of a trough in the southern hemisphere of Mars. The polygons could be an indicator that ground ice is or was present at this location. The dark streaks were formed by passing dust devils.

Location near: 67.4oS, 240.3oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

South Polar Variety

NASA Technical Reports Server (NTRS)

2005-01-01

28 July 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a view of linear troughs and mesas formed in the frozen carbon dioxide of the martian south polar residual cap. This image, obtained in May 2005, is a reminder that not all of the south polar cap landscapes resemble 'swiss cheese.'

Location near: 86.7oS, 24.8oW Image width: width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Spring

Large, Windblown Ripples

NASA Technical Reports Server (NTRS)

2003-01-01

MGS MOC Release No. MOC2-447, 9 August 2003

This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the plethora of large, windblown ripples (or small dunes) among wind-sculpted sedimentary rocks in eastern Candor Chasma. Candor Chasma is one of the troughs of the Valles Marineris, a system of chasms that would stretch all the way across North America if it were on Earth. This picture is located near 7.9oS, 64.9oW. Sunlight illuminates the scene from the left/upper left.

Detailed measured sections, cross sections, and paleogeographic reconstructions of the upper cretaceous and lower tertiary nonmarine interval, Wind River Basin, Wyoming: Chapter 10 in Petroleum systems and geologic assessment of oil and gas resources in the Wind River Basin Province, Wyoming

USGS Publications Warehouse

Johnson, Ronald C.

2007-01-01

Detailed measured sections and regional stratigraphic cross sections are used to reconstruct facies maps and interpret paleogeographic settings for the interval from the base of Upper Cretaceous Mesaverde Formation to top of lower member of the Paleocene Fort Union Formation in the Wind River Basin, Wyoming. The Mesaverde Formation spans the time during which the Upper Cretaceous seaway retreated eastward out of central Wyoming in Campanian time and the initial stages of the Lewis transgression in earliest Maastrichtian time. This retreat stalled for a considerable period of time during deposition of the lower part of the Mesaverde, creating a thick buildup of marginal marine sandstones and coaly coastal plain deposits across the western part of the basin. The Lewis sea transgressed into the northeast part of Wind River Basin, beginning in early Maastrichtian time during deposition of the Teapot Sandstone Member of the Mesaverde Formation. The Meeteetse Formation, which overlies the Teapot, was deposited in a poorly-drained coastal plain setting southwest of the Lewis seaway. The Lewis seaway, at maximum transgression, covered much of the northeast half of the Wind River Basin area but was clearly deflected around the present site of the Wind River Range, southwest of the basin, providing the first direct evidence of Laramide uplift on that range. Uplift of the Wind River Range continued during deposition of the overlying Maastrichtian Lance Formation. The Granite Mountains south of the basin also became a positive feature during this time. A rapidly subsiding trough during the Maastrichtian time formed near the presentday trough of the Wind River Basin in which more than 6,000 feet of Lance was deposited. The development of this trough appears to have begun before the adjacent Owl Creek Mountains to the north started to rise; however, a muddy facies in the upper part of Lance in the deep subsurface, just to the south, might be interpreted to indicate that the Cretaceous Cody Shale was being eroded off a rising Owl Creek Mountains in latest Cretaceous time. The Paleocene Fort Union Formation unconformably overlies older units but with only slight angular discordance around much of the margins of the Wind River Basin. Pre-Fort Union erosion was most pronounced toward the Wind River Range to the southwest, where the Fort Union ultimately overlies strata as old as the upper part of the Cretaceous Cody Shale. The unconformity appears to die out toward the basin center. Coal-forming mires developed throughout the western part of the basin near the beginning of the Paleocene. River systems entering the basin from the Wind River Range to the southwest and the Granite Mountains to the south produced areas of sandy fluvial deposition along mountain fronts. A major river system appears to have entered the basin from about the same spot along the Wind River Range throughout much of the Paleocene, probably because it became incised and could not migrate laterally. The muddy floodplain facies that developed along the deep basin trough during latest Cretaceous time, expanded during the early part of the Paleocene. Coal-forming mires that characterize part of the lower Fort Union Formation reached maximum extent near the beginning of the late Paleocene and just prior to the initial transgression of Lake Waltman. From the time of initial flooding, Lake Waltman expanded rapidly, drowning the coal-forming mires in the central part of the basin and spreading to near basin margins. Outcrop studies along the south margin of the basin document that once maximum transgression was reached, the lake was rapidly pushed basinward and replaced by fluvial environments.

Tectonic evolution of the Anadyr Basin, northeastern Eurasia, and its petroleum resource potential

NASA Astrophysics Data System (ADS)

Antipov, M. P.; Bondarenko, G. E.; Bordovskaya, T. O.; Shipilov, E. V.

2009-09-01

The published data on the sedimentation conditions, structure, and tectonic evolution of the Anadyr Basin in the Mesozoic and Cenozoic are reviewed. These data are re-examined in the context of modern tectonic concepts concerning the evolution of the northwestern Circum-Pacific Belt. The re-examination allows us not only to specify the regional geology and tectonic history, but also to forecast of the petroleum resource potential of the sedimentary cover based on a new concept. The sedimentary cover formation in the Anadyr Basin is inseparably linked with the regional tectonic evolution. The considered portion of the Chukchi Peninsula developed in the Late Mesozoic at the junction of the ocean-type South Anyui Basin, the Asian continental margin, and convergent zones of various ages extending along the Asia-Pacific interface. Strike-slip faulting and pulses of extension dominated in the Cenozoic largely in connection with oroclinal bending of structural elements pertaining to northeastern Eurasia and northwestern North America against the background of accretion of terranes along the zone of convergence with the Pacific oceanic plates. Three main stages are recognized in the formation of the sedimentary cover in the Anadyr Basin. (1) The lower portion of the cover was formed in the Late Cretaceous-Early Eocene under conditions of alternating settings of passive and active continental margins. The Cenomanian-lower Eocene transitional sedimentary complex is located largely in the southern Anadyr Basin (Main River and Lagoonal troughs). (2) In the middle Eocene and Oligocene, sedimentation proceeded against the background of extension and rifting in the northern part of the paleobasin and compression in its southern part. The compression was caused by northward migration of the foredeep in front of the accretionary Koryak Orogen. The maximum thickness of the Eocene-Oligocene sedimentary complex is noted mainly in the southern part of the basin and in the Central and East Anadyr troughs. (3) The middle Miocene resumption of sedimentation was largely related to strike-slip faulting and rifting. In the Miocene to Quaternary, sedimentation was the most intense in the central and northern parts of the Anadyr Basin, as well as in local strike-slip fault-line depressions of the Central Trough. Geological and geophysical data corroborate thrusting in the southern Anadyr Basin. The amplitude of thrusting over the Main River Trough reaches a few tens of kilometers. The vertical thickness of the tectonically screened Paleogene and Neogene rocks in the southern Main River Trough exceeds 10 km. The quantitative forecast of hydrocarbon emigration from Cretaceous and Paleogene source rocks testifies to the disbalance between hydrocarbons emigrated and accumulated in traps of petroleum fields discovered in the Anadyr Basin. The southern portion of the Anadyr Basin is the most promising for the discovery of new petroleum fields in the Upper Cretaceous, Eocene, and Upper Oligocene-Miocene porous and fracture-porous reservoir rocks in subthrust structural and lithological traps.

Does the West Salton Detachment extend through San Gorgonio Pass, southern California?

NASA Astrophysics Data System (ADS)

Matti, J. C.; Langenheim, V. E.

2008-12-01

Rift-related extension and low-angle crustal detachment are key structural elements of the late Cenozoic southern San Andreas Fault system, as manifested by the West Salton Detachment (WSD). The most northwestern exposure of the WSD is in the Santa Rosa Mts (SRM), where the Zosel Fault bottoms a hangingwall sequence of upper Cenozoic marine and terrestrial sedimentary deposits that include stratigraphic units well known throughout the Salton Trough region. We have used geologic and geophysical data to investigate the distribution of the WSD system in the northern Salton Trough, including its possible extension into and beyond San Gorgonio Pass. Although the WSD is not exposed north of the SRM, late Miocene marine and terrigenous sedimentary rocks at Garnet Hill probably are hangingwall deposits squeezed up within the San Andreas Fault zone. West of Garnet Hill lie San Gorgonio Pass (SGP) and the 3 km-high northern escarpment of the San Jacinto Mountains (SJM). In SGP, upper Cenozoic sedimentary rocks south of the Banning strand of the San Gabriel Fault include the marine Imperial Formation and associated terrestrial deposits, a sequence similar to that in the WSD hangingwall throughout the greater Salton Trough region. We propose that the WSD originally extended from the NW head of Coachella Valley west into SGP, where the detachment may form the base of the Cenozoic marine and terrestrial sedimentary sequence. The WSD probably continues west beyond SGP, with extensional translation decreasing until the detachment intersects the Banning Fault near Calimesa. There, we propose that the WSD underlies a subsurface sedimentary package north of the San Timoteo badlands and south of the Banning Fault that a gravity low suggests is 2 km thick, and that reportedly contains marine sediment penetrated in boreholes. When ~44 km of right-slip is restored on the Banning Fault (Matti and Morton, 1993), the Calimesa low restores opposite a similar low in the northwestern Coachella Valley. The juxtaposed gravity lows mark a late Cenozoic depocenter that formed at the NW head of the Salton Trough during evolution of the San Gabriel and San Andreas Faults (10 Ma to 1.2 Ma). This reconstruction has several implications: (1) the WSD was active while the late Cenozoic sedimentary sequence in SGP accumulated in its hangingwall at 7 Ma (marine Imperial Fm) and probably as early as 10 Ma (Hathaway Fm); (2) At that time the San Jacinto Mts (SJM) began to rise in the WSD footwall, shedding sediment and landslide breccia into the SGP basin. Simultaneously, Transverse Ranges sources shed sediment southwest, south, and southeast into the SGP basin and the adjoining San Timoteo basin; (3) Prior to disruption by right-slip on the Banning Fault, the WSD probably extended around the NW head of the Salton Trough, where the detachment would have separated footwall crystalline rocks of SGP from hangingwall deposits of the Salton Trough (Coachella Fanglomerate, Imperial and Painted Hill fms). The enigmatic Whitewater Fault in the SE San Bernardino Mts may be part of the WSD. (4) Because extensional translation on the WSD diminished westward through SGP, it is doubtful that >3 km of topographic relief on the WSD footwall in the SJM resulted from footwall uplift alone during the period 10 Ma to 1.2 Ma. Post-WSD Quaternary uplift must account for an unknown component of this relief.

Enhanced and asymmetric melting beneath the southern Mariana back-arc spreading ridge under the influence of the Pacific plate subduction

NASA Astrophysics Data System (ADS)

Matsuno, T.; Seama, N.; Shindo, H.; Nogi, Y.; Okino, K.

2017-12-01

Back-arc spreading ridges in the southern Mariana Trough are slow-spreading ridges but have features suggesting enhanced melting beneath the ridges and influences on seafloor spreading processes by fluid derived from the subducted Pacific slab underlying the ridges. To reveal melting and dehydration processes and dynamics in the upper mantle in the southern Mariana Trough, we conducted a marine magnetotelluric (MT) experiment along a 120 km-length transect across a ridge segment at 13°N. We obtained electromagnetic field data at 9 stations along the transect, and analyzed them for estimating MT responses, striping seafloor topographic distortion from the responses, and imaging a 2-D electrical resistivity structure by 2-D inversion of TM-mode responses. A resultant 2-D inversion model showed 1) a conductive area at 10-20 km depth beneath the ridge center, the center of which slightly offsets to the trench side, 2) a moderately conductive area expanding asymmetrically around and under the conductor of 1), 3) a resistive area thickening from the ridge center up to about 40 km on the remnant arc side, and 4) a resistive area with a constant thickness of about 150 km on the trench side. These model features suggest 1) a melt body beneath the ridge center, possibly containing slab-derived water 2) water- and melt-retained mantle area produced by hydration of the back-arc mantle wedge and asymmetric passive decompression melting in the hydrous mantle wedge, 3) cooled and residual lithospheric mantle off the ridge center, and 4) mantle wedge and subducted Pacific lithospheric mantle that are both cold and depleted. The electrical resistivity structure obtained in the southern Mariana Trough, which clearly contrasts with the structure of the central Mariana Trough at 18°N in that this lacks a conductor beneath the ridge center, provides insights on the mantle dynamics and its relation to the characteristic tectonics and many kinds of observational results in the southern Mariana Trough.

Changing monsoon and midlatitude circulation interactions over the Western Himalayas and possible links to occurrences of extreme precipitation

NASA Astrophysics Data System (ADS)

Priya, P.; Krishnan, R.; Mujumdar, Milind; Houze, Robert A.

2017-10-01

Historical rainfall records reveal that the frequency and intensity of extreme precipitation events, during the summer monsoon (June-September) season, have significantly risen over the Western Himalayas (WH) and adjoining upper Indus basin since 1950s. Using multiple datasets, the present study investigates the possible coincidences between an increasing trend of precipitation extremes over WH and changes in background flow climatology. The present findings suggest that the combined effects of a weakened southwest monsoon circulation, increased activity of transient upper-air westerly troughs over the WH region, enhanced moisture supply by southerly winds from the Arabian Sea into the Indus basin have likely provided favorable conditions for an increased frequency of certain types of extreme precipitation events over the WH region in recent decades.

Gravity modeling of the Muertos Trough and tectonic implications (north-eastern Caribbean)

USGS Publications Warehouse

Granja, Bruna J.L.; Muñoz-Martín, A.; ten Brink, Uri S.; Carbó-Gorosabel, Andrés; Llanes, Estrada P.; Martín-Dávila, J.; Cordoba-Barba, D.; Catalan, Morollon M.

2010-01-01

The Muertos Trough in the northeast Caribbean has been interpreted as a subduction zone from seismicity, leading to infer a possible reversal subduction polarity. However, the distribution of the seismicity is very diffuse and makes definition of the plate geometry difficult. In addition, the compressive deformational features observed in the upper crust and sandbox kinematic modeling do not necessarily suggest a subduction process. We tested the hypothesized subduction of the Caribbean plate's interior beneath the eastern Greater Antilles island arc using gravity modeling. Gravity models simulating a subduction process yield a regional mass deficit beneath the island arc independently of the geometry and depth of the subducted slab used in the models. This mass deficit results from sinking of the less dense Caribbean slab beneath the lithospheric mantle replacing denser mantle materials and suggests that there is not a subducted Caribbean plateau beneath the island arc. The geologically more realistic gravity model which would explain the N-S shortening observed in the upper crust requires an overthrusted Caribbean slab extending at least 60 km northward from the deformation front, a progressive increase in the thrusting angle from 8?? to 30?? reaching a maximum depth of 22 km beneath the insular slope. This new tectonic model for the Muertos Margin, defined as a retroarc thrusting, will help to assess the seismic and tsunami hazard in the region. The use of gravity modeling has provided targets for future wide-angle seismic surveys in the Muertos Margin. ?? 2010 Springer Science+Business Media B.V.

Clinical and genetic factors affecting tacrolimus trough levels and drug-related outcomes in Korean kidney transplant recipients.

PubMed

Kim, In-Wha; Moon, Yoo Jin; Ji, Eunhee; Kim, Kyung Im; Han, Nayoung; Kim, Sung Ju; Shin, Wan Gyoon; Ha, Jongwon; Yoon, Jeong-Hyun; Lee, Hye Suk; Oh, Jung Mi

2012-05-01

The purpose of this study was to characterize the effects of clinical and genetic variables on the pharmacokinetics and complications of tacrolimus during the first year after kidney transplantation. One hundred and thirty-two Korean kidney recipients who received tacrolimus were genotyped for ABCB1 (exons 12, 21, and 26) and CYP3A5 (intron 3). Tacrolimus trough levels, dose, or dose-adjusted trough levels and complications were compared among patients during the early stage (3, 7, 14, 30, and 90 days) and up to 1 year according to the genotypes. A donor source-adjusted linear mixed model with multilevel analysis adjusting for age, body weight, hematocrit, and serum creatinine showed that CYP3A5 genotype is associated with dose-adjusted level of tacrolimus (p < 0.001). The influence of ABCB1 polymorphisms on the pharmacokinetics or complications of tacrolimus was less certain in our study. The incidence of acute rejections was significantly higher in recipients of cadaveric donor kidney (p < 0.05). A generalized estimating equation model analysis showed that alopecia and hyperlipidemia were associated with dose-adjusted level of tacrolimus (p < 0.001). Genotype of CYP3A5 variants along with significant clinical covariates may be useful in individualizing tacrolimus therapy in kidney transplantation patients.

Predecessor rain events over China's low-latitude highlands associated with Bay of Bengal tropical cyclones

NASA Astrophysics Data System (ADS)

Yuan, Junpeng; Zhao, Di; Yang, Ruowen; Yang, Hongfei

2018-02-01

A predecessor rain event (PRE) is defined as organized heavy rainfall that occurs far ahead of tropical cyclone (TC), yet directly associated with the deep tropical moisture originating from the TC vicinity. The PREs occurring over China's low-latitude highlands (CLLH) in association with Bay of Bengal TCs were investigated from 1981 to 2012. Results indicate that about 19% of Bay of Bengal TCs produces PRE. The PREs frequently occur when TCs are active in the northern Bay of Bengal with northeastward paths. The PREs are more likely to appear in the pre-monsoon and post-monsoon seasons, with peaks in May and October, respectively. The median lifetime of the PREs was approximately two days. The distances between PREs and parent TCs are ranged from 745 to 1849 km, with a median distance of 1118 km. Composite results of PREs suggested that deep moisture is advected from the TC vicinity to the remote CLLH region, which is situated beneath the equatorward entrance of the upper-level East Asia subtropical jet (EASJ). The lower-level southwesterly flow, which is associated with a strong pressure gradient between the western Pacific subtropical high and a trough in Bay of Bengal, steers TCs conveying abundant moisture from the Bay of Bengal to the CLLH region. The enhancement of the ascent and frontogenesis within the equatorward entrance region of the EASJ is favorable for occurrence of PREs in CLLH. TCs may also have a dynamical role in occurrence of PREs by intensifying the upper-level EASJ.

Contrasts within an outlier-reef system: Evidence for differential quaternary evolution, south Florida windward margin, U.S.A.

USGS Publications Warehouse

Lidz, B.H.; Shinn, E.A.; Hine, A.C.; Locker, S.D.

1997-01-01

Closely spaced, high-resolution, seismic-reflection profiles acquired off the upper Florida Keys (i.e., north) reveal a platform-margin reef-and-trough system grossly similar to, yet quite different from, that previously described off the lower Keys (i.e., south). Profiles and maps generated for both areas show that development was controlled by antecedent Pleistocene topography (presence or absence of an upper-slope bedrock terrace), sediment availability, fluctuating sea level, and coral growth rate and distribution. The north terrace is sediment-covered and exhibits linear, buried, low-relief, seismic features of unknown character and origin. The south terrace is essentially sediment-free and supports multiple, massive, high-relief outlier reefs. Uranium disequilibrium series dates on outlier-reef corals indicate a Pleistocene age (~83-84 ka). A massive Pleistocene reef with both aggradational (north) and progradational (south) aspects forms the modern margin escarpment landward of the terrace. Depending upon interpretation (the north margin-escarpment reef may or may not be an outlier reef), the north margin is either more advanced or less advanced than the south margin. During Holocene sea-level rise, Pleistocene bedrock was inundated earlier and faster first to the north (deeper offbank terrace), then to the south (deeper platform surface). Holocene overgrowth is thick (8 m) on the north outer-bank reefs but thin (0.3 m) on the south outlier reefs. Differential evolution resulted from interplay between fluctuating sea level and energy regime established by prevailing east-southeasterly winds and waves along an arcuate (ENE-WSW) platform margin.

Plasma trough concentrations of darunavir/ritonavir and raltegravir in older patients with HIV-1 infection.

PubMed

Calza, L; Colangeli, V; Magistrelli, E; Bussini, L; Conti, M; Ramazzotti, E; Mancini, R; Viale, P

2017-08-01

The aim of the study was to assess plasma concentrations of darunavir/ritonavir and raltegravir in older patients compared with younger patients with HIV-1 infection. In this observational, open-label study, adult HIV-infected out-patients aged ≤ 40 years (younger patients) or ≥ 60 years (older patients) and treated with tenofovir/emtricitabine plus darunavir/ritonavir (800/100 mg daily) or raltegravir (400 mg twice daily) were asked to participate. The trough concentrations (C trough ) of darunavir/ritonavir and raltegravir were assessed at steady state using a validated high-performance liquid chromatography (HPLC)-tandem mass spectrometry method. A total of 88 HIV-positive patients were enrolled in the study. Forty-six patients were treated with darunavir/ritonavir, and 42 with raltegravir. The geometric mean plasma C trough (coefficient of variation) of raltegravir was comparable between the 19 older and 23 younger subjects: 106 ng/mL (151%) and 94 ng/mL (129%), respectively [geometric mean ratio (GMR) 0.85; 95% confidence interval (CI) 0.71-1.57; P = 0.087]. In contrast, the geometric mean plasma C trough of darunavir was significantly higher among the 21 older patients [2209 ng/mL (139%)] than among the 25 younger patients [1876 ng/mL (162%); GMR 1.56; 95% CI: 1.22-1.88; P = 0.004]. Similarly, the geometric mean C trough of ritonavir was significantly higher among older than among younger individuals. The mean plasma C trough of darunavir and ritonavir was significantly higher in older patients than in younger patients with HIV-1 infection, while the mean plasma level of raltegravir was comparable in the two groups. However, both regimens showed good tolerability in both younger and older subjects. © 2017 British HIV Association.

The Ordovician Sebree Trough: An oceanic passage to the Midcontinent United States

USGS Publications Warehouse

Kolata, Dennis R.; Huff, W.D.; Bergstrom, Stig M.

2001-01-01

The Sebree Trough is a relatively narrow, shale-filled sedimentary feature extending for several hundred kilometers across the Middle and Late Ordovician carbonate platform of the Midcontinent United States. The dark graptolitic shales within the trough stand in contrast to the coeval bryozoan-brachiopod-echinodermrich limestones on the flanking platforms. We infer from regional stratal patterns, thickness and facies trends, and temporal relations established by biostratigraphy and K-bentonite stratigraphy that the Sebree Trough initially began to develop during late Turinian to early Chatfieldian time (Mohawkian Series) as a linear bathymetric depression situated over the failed late Precambrian-Early Cambrian Reelfoot Rift. Rising sea level and positioning of a subtropical convergence zone along the southern margin of Laurentia caused the rift depression to descend into cool, oxygen-poor, phosphate-rich oceanic waters that entered the southern reaches of the rift from the Iapetus Ocean. The trough apparently formed in a system of epicontinental estuarine circulation marked by a density-stratified water column. Trough formation was accompanied by cessation of carbonate sedimentation, deposition of graptolitic shales, development of hardground omission surfaces, substrate erosion, and local phosphogenesis. The carbonate platforms on either side of the trough are dominated by bryozoan-brachiopod-echinoderm grainstones and packstones that were deposited in zones of mixing where cool, nutrient-rich waters encountered warmer shelf waters. Concurrently, lime mudstone and wackestone were deposited shoreward (northern Illinois, Wisconsin, Iowa, Minnesota, Michigan) in warmer, more tropical shallow seas. Coeval upward growth of the flanking carbonate platforms sustained and enhanced development of the trough shale facies. Five widespread diachronous late Mohawkian and Cincinnatian omission surfaces are present in the carbonate facies of the Midcontinent. These surfaces include sub-Deicke K-bentonite, DSI; top of Black River Limestone, DS2; base and top of the Guttenberg Limestone Member of the Decorah Formation, DS3 and DS4; and top of the Trenton Limestone, DS5. Some of the surfaces correspond to previously described depositional sequence boundaries. All five surfaces, which embody deepening phases on top of high-stand-systems tracts, converge in the Sebree Trough, indicating that the trough was a long-lived feature and was the source of eutrophic waters that episodically spread across the adjacent platforms, terminating carbonate production. Late Turinian and early Chatfieldian incipient drowning episodes were followed by a final drowning event that began in the Sebree Trough during the late Chatfieldian (Climacograptus spiniferus Zone) and reached southernmost Minnesota and other regions far within the platform interior by Richmondian time (Amorphognathus ordovicicus Zone).

An analysis of the synoptic and dynamical characteristics of hurricane Sandy (2012)

NASA Astrophysics Data System (ADS)

Varlas, George; Papadopoulos, Anastasios; Katsafados, Petros

2018-01-01

Hurricane Sandy affected the Caribbean Islands and the Northeastern United States in October 2012 and caused 233 fatalities, severe rainfalls, floods, electricity blackouts, and 75 billion U.S. dollars in damages. In this study, the synoptic and dynamical characteristics that led to the formation of the hurricane are investigated. The system was driven by the interaction between the polar jet displacement and the subtropical jet stream. In particular, Sandy was initially formed as a tropical depression system over the Caribbean Sea and the unusually warm sea drove its intensification. The interaction between a rapidly approaching trough from the northwest and the stagnant ridge over the Atlantic Ocean drove Sandy to the northeast coast of United States. To better understand the dynamical characteristics and the mechanisms that triggered Sandy, a non-hydrostatic mesoscale model has been used. Model results indicate that the surface heat fluxes and the moisture advection enhanced the convective available potential energy, increased the low-level convective instability, and finally deepened the hurricane. Moreover, the upper air conditions triggered the low-level frontogenesis and increased the asymmetry of the system which finally affected its trajectory.

Texture and depositional history of near-surface alluvial deposits in the central part of the western San Joaquin Valley, California

USGS Publications Warehouse

Laudon, Julie; Belitz, Kenneth

1989-01-01

Saline conditions and associated high levels of selenium and other soluble trace elements in soil, shallow ground water, and agricultural drain water of the western San Joaquin Valley, California, have prompted a study of the texture of near-surface alluvial deposits in the central part of the western valley. Texture is characterized by the percentage of coarse-grained sediment present within a specified subsurface depth interval and is used as a basis for mapping the upper 50 feet of deposits. Resulting quantitative descriptions of the deposits are used to interpret the late Quaternary history of the area. Three hydrogeologic units--Coast Range alluvium, flood-basin deposits, and Sierran sand--can be recognized in the upper 50 feet of deposits in the central part of the western San Joaquin Valley. The upper 30 feet of Coast Range alluvium and the adjacent 5 to 35 feet of flood-basin deposits are predominantly fine grained. These fine-grained Coast Range deposits are underlain by coarse-grained channel deposits. The fine-grained flood basin deposits are underlain by coarse-grained Sierran sand. The extent and orientation of channel deposits below 20 feet in the Coast Range alluvium indicate that streams draining the Coast Range may have been tributary to the axial stream that deposited the Sierran sand and that streamflow may have been to the southeast. The fining-upward stratigraphic sequence in the upper 50 feet of deposits and the headward retreat of tributary stream channels from the valley trough with time support a recent hypothesis of climatic control of alluviation in the western San Joaquin Valley.

A Simple, Inexpensive Water-Leveling Device for Ultramicrotomy.

ERIC Educational Resources Information Center

Brooks, Austin E.

1978-01-01

Describes a device for maintaining the proper water level in knife boats during ultramicrotomy. Water levels in troughs are adjusted rapidly and precisely during the cutting process. Illustrations are included. (Author/MA)

Everolimus with reduced-dose cyclosporine in de novo renal transplant recipients: Philippine experience.

PubMed

Li, J T; Danguilan, R A; Cabanayan-Casasola, C B; Talusan-Tomacruz, Y; Ona, E T

2008-09-01

The objective of this study was to describe the appropriate dose of everolimus to achieve target trough concentrations in standard-risk Filipino kidney transplant recipients. We reviewed all kidney transplant recipients from December 1, 2006 to June 15, 2007 who were given everolimus (1.5 mg/d) in combination with low-dose cyclosporine (5 mg/kg/d) and prednisone but without induction therapy for their immunosuppressive doses, trough levels, as well as hematologic and blood chemistry profiles. Target everolimus trough concentration was 3-8 ng/mL and C2 level was 1000-1400 ng/mL for the first 3 months. Among 148 patients who underwent transplantation during the study period, 26 comprised the study population but only 15 patients completed the 3-month follow-up and are the subject of this report. Their mean age was 33 years, average PRA 2%, and mean HLA mismatches 3. All were from living donors. At 7 days posttransplantation, all patients achieved or exceeded the target everolimus trough and cyclosporine C2 level. At 1 and 3 months posttransplantation the mean everolimus dose was 1.17 and 0.78 mg/d, respectively, whereas the cyclosporine dose was 195 and 148 mg/d, respectively. Three patients showed elevated alanine aminotransferase (ALT) and all patients had hypercholesterolemia after 1 month, which improved with everolimus dose reduction (half required statins). One patient experienced a Banff Grade IA acute rejection episode at 2 months posttransplantation with a serum creatinine value of 2 mg/dL after steroid pulsing. Most standard-risk Filipino kidney transplant recipients required a maintenance everolimus dose of 1 mg/d at 1 month. The cyclosporine dose requirement was also lower. A larger sample size is needed to provide a level of significance compared with other populations.

Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients.

PubMed

Chen, W-Y; Lee, C-Y; Lin, P-Y; Hsieh, C-E; Ko, C-J; Lin, K-H; Lin, C-C; Ming, Y-Z; Chen, Y-L

2017-03-01

Studies have shown that arecoline, the major alkaloid component of betel nuts, alters the activity of enzymes in the cytochrome P450 (CYP-450) family. Tacrolimus, an immunosuppressant that protects against organ rejection in transplant recipients, not only is mainly metabolized by CYP3A enzymes but also has a narrow therapeutic range. We aimed to investigate whether dose-adjusted blood trough levels of tacrolimus differed over time between betel nut-chewing and non-betel nut-chewing liver transplant recipients. In this retrospective case-control study, 14 active betel nut-using liver recipients were matched at a 1:2 ratio to 28 non-betel nut-using liver recipients by sex, age, graft source, duration of follow-up after liver transplantation, and estimated glomerular filtration rate. Differences in liver function index, renal function index, and dose-adjusted blood trough levels of tacrolimus over an 18-month period were compared between the 2 groups by using the Generalized Estimating Equation approach. Dose-adjusted blood trough levels of tacrolimus tended to be significantly (P = .04) lower in betel nut chewers (mean = 0.81, medium = 0.7, 95% confidence interval [CI] = 0.73 to 0.90) than in nonchewers (mean = 1.12, medium = 0.88, 95% CI = 1.03 to 1.22) during the 18-month study period. However, there was no significant difference in renal and liver function index between the 2 groups. Liver transplant recipients receiving tacrolimus tend to have lower blood trough levels of the drug over time if they chew betel nuts. Copyright © 2016 Elsevier Inc. All rights reserved.

Facies analysis, depositional environments and paleoclimate of the Cretaceous Bima Formation in the Gongola Sub - Basin, Northern Benue Trough, NE Nigeria

NASA Astrophysics Data System (ADS)

Shettima, B.; Abubakar, M. B.; Kuku, A.; Haruna, A. I.

2018-01-01

Facies analysis of the Cretaceous Bima Formation in the Gongola Sub -basin of the Northern Benue Trough northeastern Nigeria indicated that the Lower Bima Member is composed of alluvial fan and braided river facies associations. The alluvial fan depositional environment dominantly consists of debris flow facies that commonly occur as matrix supported conglomerate. This facies is locally associated with grain supported conglomerate and mudstone facies, representing sieve channel and mud flow deposits respectively, and these deposits may account for the proximal alluvial fan region of the Lower Bima Member. The distal fan facies were represented by gravel-bed braided river system of probably Scot - type model. This grade into sandy braided river systems with well developed floodplains facies, forming probably at the lowermost portion of the alluvial fan depositional gradient, where it inter-fingers with basinal facies. In the Middle Bima Member, the facies architecture is dominantly suggestive of deep perennial sand-bed braided river system with thickly developed amalgamated trough crossbedded sandstone facies fining to mudstone. Couplets of shallow channels are also locally common, attesting to the varying topography of the basin. The Upper Bima Member is characterized by shallow perennial sand-bed braided river system composed of successive succession of planar and trough crossbedded sandstone facies associations, and shallower channels of the flashy ephemeral sheetflood sand - bed river systems defined by interbedded succession of small scale trough crossbedded sandstone facies and parallel laminated sandstone facies. The overall stacking pattern of the facies succession of the Bima Formation in the Gongola Sub - basin is generally thinning and fining upwards cycles, indicating scarp retreat and deposition in a relatively passive margin setting. Dominance of kaolinite in the clay mineral fraction of the Bima Formation points to predominance of humid sub - tropical to tropical climatic conditions. This favors pedogenic activities which are manifested in the several occurrences of paleosols. Pronounced periods of arid climatic conditions are also notable from the subordinate smectite mineralization. Chlorite mineralization at some localities is indicative of elevation of the provenance area, and this is synonymous with deposition of the Bima Formation, because of its syn - depositional tectonics. The absences of lacustrine shales in the syn - rift stratigraphic architecture of the Bima Formation indicates that the lower Cretaceous petroleum system that are common in the West and Central African Rift basins are generally barren in the Gongola Sub - basin of the Northern Benue Trough.

Sandstone-body and shale-body dimensions in a braided fluvial system: Salt wash sandstone member (Morrison formation), Garfield County, Utah

USGS Publications Warehouse

Robinson, J.W.; McCabea, P.J.

1997-01-01

Excellent three-dimensional exposures of the Upper Jurassic Salt Wash Sandstone Member of the Morrison Formation in the Henry Mountains area of southern Utah allow measurement of the thickness and width of fluvial sandstone and shale bodies from extensive photomosaics. The Salt Wash Sandstone Member is composed of fluvial channel fill, abandoned channel fill, and overbank/flood-plain strata that were deposited on a broad alluvial plain of low-sinuosity, sandy, braided streams flowing northeast. A hierarchy of sandstone and shale bodies in the Salt Wash Sandstone Member includes, in ascending order, trough cross-bedding, fining-upward units/mudstone intraclast conglomerates, singlestory sandstone bodies/basal conglomerate, abandoned channel fill, multistory sandstone bodies, and overbank/flood-plain heterolithic strata. Trough cross-beds have an average width:thickness ratio (W:T) of 8.5:1 in the lower interval of the Salt Wash Sandstone Member and 10.4:1 in the upper interval. Fining-upward units are 0.5-3.0 m thick and 3-11 m wide. Single-story sandstone bodies in the upper interval are wider and thicker than their counterparts in the lower interval, based on average W:T, linear regression analysis, and cumulative relative frequency graphs. Multistory sandstone bodies are composed of two to eight stories, range up to 30 m thick and over 1500 m wide (W:T > 50:1), and are also larger in the upper interval. Heterolithic units between sandstone bodies include abandoned channel fill (W:T = 33:1) and overbank/flood-plain deposits (W:T = 70:1). Understanding W:T ratios from the component parts of an ancient, sandy, braided stream deposit can be applied in several ways to similar strata in other basins; for example, to (1) determine the width of a unit when only the thickness is known, (2) create correlation guidelines and maximum correlation lengths, (3) aid in interpreting the controls on fluvial architecture, and (4) place additional constraints on input variables to stratigraphie and fluid-flow modeling. The usefulness of these types of data demonstrates the need to develop more data sets from other depositional environments.

Anatomy of the Chesapeake Bay impact structure revealed by seismic imaging, Delmarva Peninsula, Virginia, USA

USGS Publications Warehouse

Catchings, R.D.; Powars, D.S.; Gohn, G.S.; Horton, J. Wright; Goldman, M.R.; Hole, J.A.

2008-01-01

A 30-km-long, radial seismic reflection and refraction survey completed across the northern part of the late Eocene Chesapeake Bay impact structure (CBIS) on the Delmarva Peninsula, Virginia, USA, confirms that the CBIS is a complex central-peak crater. We used a tomographic P wave velocity model and low-fold reflection images, constrained by data from two deep boreholes located on the profile, to interpret the structure and composition of the upper 5 km of crust. The seismic images exhibit well-defined structural features, including (with increasing radial distance) a collapsed central uplift, a breccia-filled moat, and a collapsed transient-crater margin (which collectively constitute a ???40-km-wide collapsed transient crater), and a shallowly deformed annular trough. These seismic images are the first to resolve the deep structure of the crater (>1 km) and the boundaries between the central uplift, moat, and annular trough. Several distinct seismic signatures distinguish breccia units from each other and from more coherent crystalline rocks below the central uplift, moat, and annular trough. Within the moat, breccia extends to a minimum depth of 1.5 km or a maximum of 3.5 km, depending upon the interpretation of the deepest layered materials. The images show ???350 to 500 m of postimpact sediments above the impactites. The imaged structure of the CBIS indicates a complex sequence of event during the cratering process that will provide new constraints for numerical modeling. Copyright 2008 by the American Geophysical Union.

ITCZ and ENSO pacing on East Asian winter monsoon variation during the Holocene: Sedimentological evidence from the Okinawa Trough

NASA Astrophysics Data System (ADS)

Zheng, Xufeng; Li, Anchun; Wan, Shiming; Jiang, Fuqing; Kao, Shuh Ji; Johnson, Cody

2014-07-01

Deep-sea fan sediments provide an excellent geological archive for paleoenvironment reconstruction. Grain size, clay mineral and elemental (Ti, Fe, Ca) compositions were measured for a core retrieved from a submarine fan in the Okinawa Trough. Varimax-rotated Principal Component Analysis (V-PCA) on time-evolution of grain size spectrum reveals that, since the Holocene, sediment was transported mainly by the benthic nepheloid layer (33%) and upper layers (33%) which is driven by the East Asian winter monsoon (EAWM). The intensification of the Kuroshio Current during the Holocene, masks the fluvial signal of the summer monsoon and obstructs clay minerals derived from the Yellow River, a major contributor prior to 12 ka BP. A new grain size index (GSI), which represents the EAWM well, exhibits a negative correlation with the δ18O record in Dongge Cave, China during the Holocene when sea level was relatively steady. This anticorrelation suggests the southward migration of the Intertropical Convergence Zone (ITCZ). The consistency among our records and rainfall records in Peru, Ti counts in the Cariaco Basin, monsoon records in Oman and the averaged summer insolation pattern at 30°N further support the ITCZ's impact on monsoon systems globally. Cross-Correlation Analyses for GSI and log(Ti/Ca) against δ18O record in Dongge Cave reveal a decoupling between the East Asian winter and summer monsoon during 5500-2500 cal yr BP, with greater complexity in the last 2500 years. This can be attributed to exacerbated ENSO mode fluctuations and possibly anthropogenic interference superimposed on insolation and ITCZ forcing.

ITCZ and ENSO pacing on East Asian winter monsoon variation during the Holocene: Sedimentological evidence from the Okinawa Trough

NASA Astrophysics Data System (ADS)

Zheng, Xufeng; Li, Anchun; Wan, Shiming; Kao, Shuhji; Kuhn, Gerhard

2016-04-01

Deep-sea fan sediments provide an excellent geological archive for paleoenvironment reconstruction. Grain size, clay mineral and elemental (Ti, Fe, Ca) compositions were measured for a core retrieved from a submarine fan in the Okinawa Trough. Varimax-rotated Principal Component Analysis (V-PCA) on time-evolution of grain size spectrum reveals that, since the Holocene, sediment was transported mainly by the benthic nepheloid layer (33%) and upper layers (33%) which is driven by the East Asian winter monsoon (EAWM). The intensification of the Kuroshio Current during the Holocene, masks the fluvial signal of the summer monsoon and obstructs clay minerals derived from the Yellow River, a major contributor prior to 12 ka BP. A new grain size index (GSI), which represents the EAWM well, exhibits a negative correlation with the δ18O record in Dongge Cave, China during the Holocene when sea level was relatively steady. This anticorrelation suggests the southward migration of the Intertropical Convergence Zone (ITCZ). The consistency among our records and rainfall records in Peru, Ti counts in the Cariaco Basin, monsoon records in Oman and the averaged summer insolation pattern at 30°N further support the ITCZ's impact on monsoon systems globally. Cross-Correlation Analyses for GSI and log(Ti/Ca) against δ18O record in Dongge Cave reveal a decoupling between the East Asian winter and summer monsoon during 5500-2500 cal yr BP, with greater complexity in the last 2500 years. This can be attributed to exacerbated ENSO mode fluctuations and possibly anthropogenic interference superimposed on insolation and ITCZ forcing.

Rinse trough with improved flow

DOEpatents

O'Hern, Timothy J.; Grasser, Thomas W.

1998-01-01

Novel rinse troughs accomplish thorough uniform rinsing. The troughs are suitable for one or more essentially planar objects having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs provide uniform rinse fluid flow over the objects' surfaces to accomplish a more thorough rinse than prior art troughs.

Bottom-water observations in the Vema fracture zone

NASA Astrophysics Data System (ADS)

Eittreim, Stephen L.; Biscaye, Pierre E.; Jacobs, Stanley S.

1983-03-01

The Vema fracture zone trough, at 11°N between 41° and 45°E, is open to the west at the 5000-m level but is silled at the 4650-m level on the east where it intersects the axis of the Mid-Atlantic Ridge. The trough is filled with Antarctic Bottom Water (AABW) with a potential temperature of 1.32°C and salinity of 34.82 ppt. The bottom water is thermally well mixed in a nearly homogeneous layer about 700 m thick. The great thickness of this bottom layer, as compared with the bottom-water structure of the western Atlantic basin, may result from enhanced mixing induced by topographic constriction at the west end of the fracture zone trough. A benthic thermocline, with potential temperature gradients of about 1.2 mdeg m-1, is associated with an abrupt increase in turbidity with depth at about 1200 m above bottom. A transitional layer of more moderate temperature gradients, about 0.4 mdeg m-1, lies between the benthic thermocline above and the AABW below. The AABW layer whose depth-averaged suspended paniculate concentrations range from 8 to 19 μg L-1, is consistently higher in turbidity than the overlying waters. At the eastern end of the trough, 140 m below sill depth, very low northeastward current velocities, with maximums of 3 cm s-1, were recorded for an 11-day period.

Rinse trough with improved flow

DOEpatents

O`Hern, T.J.; Grasser, T.W.

1998-08-11

Novel rinse troughs accomplish thorough uniform rinsing. The troughs are suitable for one or more essentially planar objects having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs provide uniform rinse fluid flow over the objects` surfaces to accomplish a more thorough rinse than prior art troughs. 5 figs.

The development of the continental margin of eastern North America-conjugate continental margin to West Africa

USGS Publications Warehouse

Dillon, William P.; Schlee, J.S.; Klitgord, Kim D.

1988-01-01

The continental margin of eastern North America was initiated when West Africa and North America were rifted apart in Triassic-Early Jurassic time. Cooling of the crust and its thinning by rifting and extension caused subsidence. Variation in amounts of subsidence led to formation of five basins. These are listed from south to north. (1) The Blake Plateau Basin, the southernmost, is the widest basin and the one in which the rift-stage basement took longest to form. Carbonate platform deposition was active and persisted until the end of Early Cretaceous. In Late Cretaceous, deposition slowed while subsidence persisted, so a deep water platform was formed. Since the Paleocene the region has undergone erosion. (2) The Carolina Trough is narrow and has relatively thin basement, on the basis of gravity modeling. The two basins with thin basement, the Carolina Trough and Scotian Basin, also show many salt diapirs indicating considerable deposition of salt during their early evolution. In the Carolina Trough, subsidence of a large block of strata above the flowing salt has resulted in a major, active normal fault on the landward side of the basin. (3) The Baltimore Canyon Trough has an extremely thick sedimentary section; synrift and postrift sediments exceed 18 km in thickness. A Jurassic reef is well developed on the basin's seaward side, but post-Jurassic deposition was mainly non-carbonate. In general the conversion from carbonate to terrigenous deposition, characteristics of North American Basins, occurred progressively earlier toward the north. (4) The Georges Bank Basin has a complicated deep structure of sub-basins filled with thick synrift deposits. This may have resulted from some shearing that occurred at this offset of the continental margin. Postrift sediments apparently are thin compared to other basins-only about 8 km. (5) The Scotian Basin, off Canada, contains Jurassic carbonate rocks, sandstone, shale and coal covered by deltaic deposits and Upper Cretaceous deeper water chalk and shale. ?? 1988.

Tufts submarine fan: turbidity-current gateway to Escanaba Trough

USGS Publications Warehouse

Reid, Jane A.; Normark, William R.

2003-01-01

Turbidity-current overflow from Cascadia Channel near its western exit from the Blanco Fracture Zone has formed the Tufts submarine fan, which extends more than 350 km south on the Pacific Plate to the Mendocino Fracture Zone. For this study, available 3.5-kHz high-resolution and airgun seismic-reflection data, long-range side-scan sonar images, and sediment core data are used to define the growth pattern of the fan. Tufts fan deposits have smoothed and filled in the linear ridge-and-valley relief over an area exceeding 23,000 km2 on the west flank of the Gorda Ridge. The southernmost part of the fan is represented by a thick (as much as 500 m) sequence of turbidite deposits ponded along more than 100 km of the northern flank of the Mendocino Fracture Zone. Growth of the Tufts fan now permits turbidity-current overflow from Cascadia Channel to reach the Escanaba Trough, a deep rift valley along the southern axis of the Gorda Ridge. Scientific drilling during both the Deep Sea Drilling Project (DSDP) and the Ocean Drilling Program (ODP) provided evidence that the 500-m-thick sediment fill of Escanaba Trough is dominantly sandy turbidites. Radiocarbon dating of the sediment at ODP Site 1037 showed that deposition of most of the upper 120 m of fill was coincident with Lake Missoula floods and that the provenance of the fill is from the eastern Columbia River drainage basin. The Lake Missoula flood discharge with its entrained sediment continued flowing downslope upon reaching the ocean as hyperpycnally generated turbidity currents. These huge turbidity currents followed the Cascadia Channel to reach the Pacific Plate, where overbank flow provided a significant volume of sediment on Tufts fan and in Escanaba Trough. Tufts fan and Tufts Abyssal Plain to the west probably received turbidite sediment from the Cascadia margin during much of the Pleistocene.

Topographic and sedimentary features in the Yap subduction zone and their implications for the Caroline Ridge subduction

NASA Astrophysics Data System (ADS)

Dong, Dongdong; Zhang, Zhengyi; Bai, Yongliang; Fan, Jianke; Zhang, Guangxu

2018-01-01

The Yap subduction zone in the western Pacific presents some unique features compared to normal intra-oceanic subduction zones such as the subduction of an oceanic plateau. However, due to the relative paucity of geophysical data, the detailed structure remains unknown in this area. In this study, we present the latest high-quality swath bathymetry and multi-channel seismic data acquired synchronously in 2015 across the Yap subduction zone. The topographic and sedimentary features are intensively investigated and a modified evolutionary model of the Yap subduction zone is proposed. The two-stage evolution of the Parece Vela Basin (PVB) produced fabrics that are N-S trending and NW-SE trending. Our seismic data clearly reveal landslide deposits at the upper slope break of the forearc, to the north of the Yap Island, which was identified as the fault notch denoting a lithological boundary in previous work. The swath bathymetry and seismic profile reveal detailed horst and graben structures, including a crescent-shaped fault zone near the contact between the Yap Trench and the Caroline Ridge. A simple geometric model is proposed to explain the structure formation, indicating that the higher topography of the Caroline Ridge resulted in enhanced bending-related extension. A seismic angular unconformity (named R1) is identified in the Sorol Trough, marking the onset of rifting in the trough. Based on the sequence thickness and deposition rate by Deep Sea Drilling Project (DSDP), it is deduced that the Sorol Trough formed at 10 Ma or even earlier. A modified model for the Yap subduction zone evolution is proposed, incorporating three major tectonic events: the proto-Yap Arc rupture in the Oligocene, the collision of the Caroline Ridge and the Yap Trench in the late Oligocene or middle Miocene, and the onset of the Sorol Trough rifting in the late Miocene.

Changing monsoon and midlatitude circulation interactions over the Western Himalayas and possible links to occurrences of extreme precipitation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Priya, P.; Krishnan, R.; Mujumdar, Milind

Historical rainfall records reveal that the frequency and intensity of extreme precipitation events, during the summer monsoon (June to September) season, have significantly risen over the Western Himalayas (WH) and adjoining upper Indus basin since 1950s. Using multiple datasets, the present study investigates the possible coincidences between an increasing trend of precipitation extremes over WH and changes in background flow climatology. The present findings suggest that the combined effects of a weakened southwest monsoon circulation, increased activity of transient upper-air westerly troughs over the WH region, enhanced moisture supply by southerly winds from the Arabian Sea into the Indus basinmore » have likely provided favorable conditions for an increased frequency of certain types of extreme precipitation events over the WH region in recent decades.« less

Interannual variation of springtime biomass burning in Indochina: Regional differences, associated atmospheric dynamical changes, and downwind impacts.

PubMed

Huang, Wan-Ru; Wang, Sheng-Hsiang; Yen, Ming-Cheng; Lin, Neng-Huei; Promchote, Parichart

2016-09-16

During March and April, widespread burning occurs across farmlands in Indochina in preparation for planting at the monsoon onset. The resultant aerosols impact the air quality downwind. In this study, we investigate the climatic aspect of the interannual variation of springtime biomass burning in Indochina and its correlation with air quality at Mt. Lulin in Taiwan using long-term (2005-2015) satellite and global reanalysis data. Based on empirical orthogonal function (EOF) analysis, we find that the biomass burning activities vary with two geographical regions: northern Indochina (the primary EOF mode) and southern Indochina (the secondary EOF mode). We determine that the variation of biomass burning over northern Indochina is significantly related with the change in aerosol concentrations at Mt. Lulin. This occurs following the change in the so-called India-Burma Trough in the lower and middle troposphere. When the India-Burma Trough is intensified, a stronger northwesterly wind (to the west of the trough) transports the dryer air from higher latitude into northern Indochina, and this promotes local biomass burning activities. The increase in upward motion to the east of the intensified India-Burma Trough lifts the aerosols, which are transported toward Taiwan by the increased low-level westerly jet. Further diagnoses revealed the connection between the India-Burma Trough and the South Asian jet's wave train pattern as well as the previous winter's El Niño - Southern Oscillation phase. This information highlights the role of the India-Burma Trough in modulating northern Indochina biomass burning and possibly predicting aerosol transport to East Asia on the interannual time scale.

Corrugated pipe adhesive applicator apparatus

DOEpatents

Shirey, R.A.

1983-06-14

Apparatus for coating selected portions of the troughs of a corrugated pipe with an adhesive includes a support disposed within the pipe with a reservoir containing the adhesive disposed on the support. A pump, including a spout, is utilized for supplying the adhesive from the reservoir to a trough of the pipe. A rotatable applicator is supported on the support and contacts the trough of the pipe. The applicator itself is sized so as to fit within the trough, and contacts the adhesive in the trough and spreads the adhesive in the trough upon rotation. A trough shield, supported by the support and disposed in the path of rotation of the applicator, is utilized to prevent the applicator from contacting selected portions of the trough. A locator head is also disposed on the support and provides a way for aligning the spout, the applicator, and the trough shield with the trough. 4 figs.

Signs of Soft-Sediment Deformation at 'Slickrock'

NASA Technical Reports Server (NTRS)

2004-01-01

Geological examination of bedding textures indicates three stratigraphic units in an area called 'Slickrock' located in the martian rock outcrop that NASA's Opportunity examined for several weeks. This is an image Opportunity took from a distance of 2.1 meters (6.9 feet) during the rover's 45th sol on Mars (March 10, 2004) and shows a scour surface or ripple trough lamination. These features are consistent with sedimentation on a moist surface where wind-driven processes may also have occurred.

[figure removed for brevity, see original site] Figure 1

In Figure 1, interpretive blue lines indicate boundaries between the units. The upper blue line may coincide with a scour surface. The lower and upper units have features suggestive of ripples or early soft-sediment deformation. The central unit is dominated by fine, parallel stratification, which could have been produced by wind-blown ripples.

[figure removed for brevity, see original site] Figure 2

In Figure 2, features labeled with red letters are shown in an enlargement of portions of the image. 'A' is a scour surface characterized by truncation of the underlying fine layers, or laminae. 'B' is a possible soft-sediment buckling characterized by a 'teepee' shaped structure. 'C' shows a possible ripple beneath the arrow and a possible ripple cross-lamination to the left of the arrow, along the surface the arrow tip touches. 'D' is a scour surface or ripple trough lamination. These features are consistent with sedimentation on a moist surface where wind-driven processes may also have occurred.

On the unseasonal flooding over the Central United States during December 2015 and January 2016

NASA Astrophysics Data System (ADS)

Zhang, Wei; Villarini, Gabriele

2017-11-01

The unseasonal winter heavy rainfall and flooding that occurred during December 2015-January 2016 had large socio-economic impacts for the central United States. Here we examine the climatic conditions that led to the observed extreme precipitation, and compare and contrast them with the 1982/1983 and 2011/2012 winters. The large precipitation amounts associated with the 1982/1983 and 2015/2016 winter flooding were linked to the strongly positive North Atlantic Oscillation (NAO), with large moisture transported from the Gulf of Mexico. The anomalous upper-level trough in the 1982- and 2015- Decembers over the western United States was also favorable for strong precipitation by leading the cold front over the central United States. In contrast, the extremely positive NAO in December 2011 did not lead to heavy rainfall and flooding because the Azores High center shifted too far westward (like a blocking high) preventing moisture from moving towards the central and southeastern United States.

Influence of ENSO on Gulf Stream cyclogenesis and the North Atlantic storm track

NASA Astrophysics Data System (ADS)

Li, C.; Schemm, S.; Ciasto, L.; Kvamsto, N. G.

2015-12-01

There is emerging evidence that climate in the North Atlantic-European sector is sensitive to vacillations of tropical Pacific sea surface temperatures, in particular, the central Pacific flavour of the El Nino Southern Oscillation (ENSO) and concomitant trends in atmospheric heating. The frequency of central Pacific ENSOs appears to have increased over the last decades and some studies suggest it may continue increasing in the future, but the precise mechanisms by which these events affect the North Atlantic synoptic scale circulation are poorly understood. Here, we show that central Pacific ENSOs influence where midlatitude cyclogenesis occurs over the Gulf Stream, producing more cyclogenesis in the jet exit region rather than in the climatologically preferred jet entrance region. The cyclones forming over the Gulf Stream in central Pacific ENSO seasons tend to veer north, penetrating deeper into the Arctic rather than into continental Europe. The shift in cyclogenesis is linked to changes in the large scale circulation, namely, the upper-level trough formed in the lee of the Rocky Mountains.

Extended-interval Dosing of Gentamicin in Premature Neonates Born at <32 Weeks' Gestation and >7 Days of age.

PubMed

Sundaram, Arun; Alshaikh, Belal; Dersch-Mills, Deonne; Dobry, Jenna; Akierman, Albert R; Yusuf, Kamran

2017-06-01

Extended-interval dosing (EID) regimens of gentamicin have been validated for treating confirmed or suspected early- and late-onset sepsis in preterm infants in the first week of life. Despite the marked changes in volume of distribution and renal clearance in preterm infants after the first few days of life, few studies have validated EID regimens of gentamicin in this population. The objective of the study was to evaluate an EID regimen of gentamicin in infants born at <32 weeks' gestational age and aged >7 days. This observational study of an EID regimen was conducted in 39 infants. Dosing interval was based on the serum drug concentration at 22 hours after the administration of the first dose of 5 mg/kg. Gentamicin peak (5-12 µg/mL) and trough (<2 µg/mL) levels were compared to those in a historical control group of 39 infants who received traditional-interval dosing (TID) of 2.5 mg/kg of gentamicin with dosing intervals of 8, 12, or 24 hours. There were no differences in birthweight, gestational age at birth, postmenstrual age, weight at the start of gentamicin administration, postnatal age, small for gestational age status, antenatal corticosteroid use, or postnatal indomethacin exposure between the 2 groups. In the EID group, dosing intervals were 24 hours in 30 infants, 36 hours in 6 infants, and 48 hours in 3 infants. Compared with the TID group (n = 39), the EID group had a significantly higher peak level (median, 9.0 vs 4.7 µg/mL) and a significantly lower trough level (median, 0.7 vs 1.1 µg/mL) (both, P < 0.001). On regression analysis, the postmenstrual age was correlated significantly with trough levels in the EID group. There was no adverse effect on renal function in either group. On follow-up, 1 infant in the EID group and 2 infants in the TID group had evidence of sensorineural hearing loss. In infants born at <32 weeks' gestation and >7 days of age, an EID gentamicin regimen, with a dosing interval based on a single concentration measurement at 22 hours after the administration of the first dose, achieved therapeutic peak and trough levels and performed significantly better than did a TID regimen in reaching target peak and trough levels. Larger-scale trials are needed for assessing the clinical efficacy (treatment failure/success) of these regimens. Copyright © 2017 Elsevier HS Journals, Inc. All rights reserved.

Healthcare-associated Staphylococcus aureus Bacteremia in Children: Evidence for Reverse Vancomycin Creep and Impact of Vancomycin Trough Values on Outcome.

PubMed

McNeil, J Chase; Kok, Eric Y; Forbes, Andrea R; Lamberth, Linda; Hulten, Kristina G; Vallejo, Jesus G; Mason, Edward O; Kaplan, Sheldon L

2016-03-01

Elevated vancomycin minimum inhibitory concentrations (MICs) in Staphylococcus aureus have been associated with worse clinical outcomes in adults. For invasive meticillin-resistant S. aureus (MRSA) infections in adults, the Infectious Diseases Society of America recommends targeting vancomycin serum trough concentrations between 15 and 20 μg/mL. We evaluated trends in vancomycin MICs from healthcare-associated (HCA) S. aureus bacteremia isolates in children in addition to correlating vancomycin serum trough levels with clinical outcomes. Patients and isolates were identified from a prospective S. aureus surveillance study at Texas Children's Hospital (TCH). HCA S. aureus bacteremia isolates from 2003 to 2013 were selected. Vancomycin MICs by E-test were determined and medical records were reviewed. Acute kidney injury (AKI) was defined as doubling of the baseline serum creatinine. Three hundred forty-one isolates met inclusion criteria. We observed a reverse vancomycin creep among MRSA isolates in the study period with a decline in the proportion of isolates with vancomycin MIC ≥ 2 μg/mL (from 32.7% to 5.6%; P < 0.001). However, the proportion of MSSA isolates with MIC ≥ 2 μg/mL increased (from 2.9% to 9%; P = 0.04). Among patients who had vancomycin troughs performed, there was no difference in duration of bacteremia or fever with vancomycin trough >15 versus <15 μg/mL. A vancomycin trough >15 μg/mL was, however, an independent risk factor for AKI. Vancomycin MICs are shifting among HCA S. aureus bacteremia isolates with significant differences between MRSA and MSSA at TCH. Higher vancomycin troughs did not improve outcomes in pediatric HCA S. aureus bacteremia but were associated with increased nephrotoxicity. Further studies are needed to better understand optimal management of children with S. aureus bacteremia.

Meteorological features associated with unprecedented precipitation over India during 1st week of March 2015

NASA Astrophysics Data System (ADS)

Kumar, Naresh; Mohapatra, M.; Jaswal, A. K.

2017-07-01

Unprecedented precipitation along with heavy falls occurred over many parts of India from 28th February to 2nd March 2015. Many of the stations of northwest and central India received an all time high 24 hr cumulative precipitation of March during this period. Even the national capital, New Delhi, broke all the previous historical 24 hr rainfall records of the last 100 years to the rainfall record in March 2015. Due to this event, huge loss to agricultural and horticultural crops occurred in several parts of India. In the present study, an attempt is made to understand the various meteorological features associated with this unprecedented precipitation event over India. It occurred due to the presence of an intense western disturbance (WD) over Afghanistan and neighbouring areas in the form of north-south oriented deep trough in westerlies in middle and upper tropospheric levels with its southern end deep in the Arabian Sea, which pumped huge moisture feed over Indian region. Also, there was a jet stream with core wind speed up to 160 knots that generated high positive divergence at upper tropospheric level over Indian region; along with this there was high magnitude of negative vertical velocity and velocity convergence were there at middle tropospheric level. It caused intense upward motion and forced lower levels air to rise and strengthen the lower levels cyclonic circulations (CCs)/Lows. Moreover, the induced CCs/Lows at lower tropospheric levels associated with WD were more towards south of its normal position. Additionally, there was wind confluence over central parts of India due to westerlies in association with WD and easterlies from anticyclone over north Bay of Bengal. Thus, intense WD along with wind confluence between westerlies and easterlies caused unprecedented precipitation over India during the 1st week of March 2015.

A Multicentre Study on the Efficacy, Safety and Pharmacokinetics of IqYmune®, a Highly Purified 10% Liquid Intravenous Immunoglobulin, in Patients with Primary Immune Deficiency.

PubMed

Krivan, Gergely; Chernyshova, Ludmila; Kostyuchenko, Larysa; Lange, Andrzej; Nyul, Zoltan; Derfalvi, Beata; Musial, Jacek; Bellon, Anne; Kappler, Martin; Sadoun, Alain; Bernatowska, Ewa

2017-08-01

This multicentre, open-label, prospective, single-arm study was designed to evaluate the efficacy, pharmacokinetics, and safety of IqYmune®, a highly purified 10% polyvalent immunoglobulin preparation for intravenous administration in patients with primary immunodeficiency. IqYmune® was administered to 62 patients (aged 2-61 years) with X-linked agammaglobulinemia or common variable immune deficiency at a dose from 0.22 to 0.97 g/kg every 3 to 4 weeks for 12 months with an infusion rate up to 8 mL/kg/h. A pharmacokinetic study was performed at steady state between the 8th and the 9th infusion. A single case of serious bacterial infection was observed, leading to an annualized rate of serious bacterial infections/patient (primary endpoint) of 0.017 (98% CI: 0.000, 0.115). Overall, 228 infections were reported, most frequently bronchitis, chronic sinusitis, nasopharyngitis and upper respiratory tract infection. The mean annualized rate of infections was 3.79/patient. A lower risk of infections was associated with an IgG trough level > 8 g/L (p = 0.01). The mean annualized durations of absence from work or school and of hospitalization due to infections were 1.01 and 0.89 days/patient, respectively. The mean serum IgG trough level before the 6th infusion was 7.73 g/L after a mean dose of IqYmune® of 0.57 g/kg. The pharmacokinetic profile of IqYmune® was consistent with that of other intravenous immunoglobulins. Overall, 15.5% of infusions were associated with an adverse event occurring within 72 h post infusion. Headache was the most common adverse event. In conclusion, IqYmune® was shown to be effective and well tolerated in patients with primary immunodeficiency.

Directed flow fluid rinse trough

DOEpatents

Kempka, Steven N.; Walters, Robert N.

1996-01-01

Novel rinse troughs accomplish thorough uniform rinsing. The tanks are suitable for one or more essentially planar items having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs also require less rinse fluid to accomplish a thorough rinse than prior art troughs.

Directed flow fluid rinse trough

DOEpatents

Kempka, S.N.; Walters, R.N.

1996-07-02

Novel rinse troughs accomplish thorough uniform rinsing. The tanks are suitable for one or more essentially planar items having substantially the same shape. The troughs ensure that each surface is rinsed uniformly. The new troughs also require less rinse fluid to accomplish a thorough rinse than prior art troughs. 9 figs.

Environments of Long-Lived Mesoscale Convective Systems Over the Central United States in Convection Permitting Climate Simulations

NASA Astrophysics Data System (ADS)

Yang, Qing; Houze, Robert A.; Leung, L. Ruby; Feng, Zhe

2017-12-01

Continental-scale convection-permitting simulations of the warm seasons of 2011 and 2012 using the Weather Research and Forecasting model reproduce realistic structure and frequency distribution of lifetime and event mean precipitation of mesoscale convective systems (MCSs) over the central United States. Analysis is performed to determine the environmental conditions conducive to generating long-lived MCSs. The simulations show that MCSs systematically form over the central Great Plains ahead of a trough in the westerlies in combination with an enhanced low-level moist jet from the Gulf of Mexico. These environmental properties at the time of storm initiation are most prominent for the MCSs that persist for the longest times. MCSs reaching lifetimes of 9 h or more occur closer to the approaching trough than shorter-lived MCSs. These long-lived MCSs exhibit the strongest feedback to the environment through diabatic heating in the trailing regions of the MCSs. The feedback strengthens the synoptic-scale trough associated with the MCS by producing an anomaly circulation characterized by a divergent perturbation at high levels over the MCS and a midlevel cyclonic circulation perturbation near the trough line in association with the trailing portion of the MCS. The quasi-balanced mesoscale vortex may help to maintain the MCS over a long period of time by feeding dry, cool air into the environment at the rear of the MCS region that enhances evaporative cooling and helps maintain the MCS.

Calibrated Seismic Imaging of Eddy-Dominated Warm-Water Transport Across the Bellingshausen Sea, Southern Ocean

NASA Astrophysics Data System (ADS)

Gunn, K. L.; White, N. J.; Larter, R. D.; Caulfield, C. P.

2018-04-01

Seismic reflection images of thermohaline circulation from the Bellingshausen Sea, adjacent to the West Antarctica Peninsula, were acquired during February 2015. This survey shows that bright reflectivity occurs throughout the upper 300 m. By calibrating these seismic images with coeval hydrographic measurements, intrusion of warm water features onto the continental shelf at Marguerite and Belgica Troughs is identified and characterized. These features have distinctive lens-shaped patterns of reflectivity with lengths of 0.75-11.00 km and thicknesses of 100-150 m, suggesting that they are small mesoscale to submesoscale eddies. Abundant eddies are observed along a transect that crosses Belgica Trough. Near Alexander Island Drift, a large, of order (O)102 km3, bowl-like feature, that may represent an anticyclonic Taylor column, is imaged on a pair of orthogonal images. A modified iterative procedure is used to convert seismic imagery into maps of temperature that enable the number and size of eddies being transported onto the shelf to be quantified. Finally, analysis of prestack shot records suggests that these eddies are advecting southward at speeds of O>(0.1>) m s-1, consistent with limited legacy hydrographic measurements. Concentration of observed eddies south of the Southern Antarctic Circumpolar Current Front implies they represent both a dominant, and a long-lived, mechanism of warm-water transport, especially across Belgica Trough. Our observations suggest that previous estimates of eddy frequency may have been underestimated by up to 1 order of magnitude, which has significant implications for calculations of ice mass loss on the shelf of the West Antarctic Peninsula.

Intrusive rocks of the Wadi Hamad Area, North Eastern Desert, Egypt: Change of magma composition with maturity of Neoproterozoic continental island arc and the role of collisional plutonism in the differentiation of arc crust

NASA Astrophysics Data System (ADS)

Basta, Fawzy F.; Maurice, Ayman E.; Bakhit, Bottros R.; Azer, Mokhles K.; El-Sobky, Atef F.

2017-09-01

The igneous rocks of the Wadi Hamad area are exposed in the northernmost segment of the Arabian-Nubian Shield (ANS). These rocks represent part of crustal section of Neoproterozoic continental island arc which is intruded by late to post-collisional alkali feldspar granites. The subduction-related intrusives comprise earlier gabbro-diorites and later granodiorites-granites. Subduction setting of these intrusives is indicated by medium- to high-K calc-alkaline affinity, Ta-Nb troughs on the spider diagrams and pyroxene and biotite compositions similar to those crystallized from arc magmas. The collisional alkali feldspar granites have high-K highly fractionated calc-alkaline nature and their spider diagrams almost devoid of Ta-Nb troughs. The earlier subduction gabbro-diorites have lower alkalis, LREE, Nb, Zr and Hf values compared with the later subduction granodiorites-granites, which display more LILE-enriched spider diagrams with shallower Ta-Nb troughs, reflecting variation of magma composition with arc evolution. The later subduction granitoids were generated by lower degree of partial melting of mantle wedge and contain higher arc crustal component compared with the earlier subduction gabbro-diorites. The highly silicic alkali feldspar granites represent extensively evolved melts derived from partial melting of intermediate arc crustal sources during the collisional stage. Re-melting of arc crustal sources during the collisional stage results in geochemical differentiation of the continental arc crust and the silicic collisional plutonism drives the composition of its upper part towards that of mature continental crust.

Scaly-skinned Mars

NASA Technical Reports Server (NTRS)

2002-01-01

[figure removed for brevity, see original site]

The style of erosion along the highlands-lowlands boundary of southern Elysium Planitia has produced a strange pattern of troughs that look like the skin of a reptile. In reality, a very clear process of landscape degradation is evident in this image. Some process has produced polygon-shaped troughs that create zones of weakness in the uppermost crust. It is likely that wind-blown particles deepen and widen the troughs, producing isolated knobs and mesas. Ultimately, the erosional reworking of the landscape is so complete that all signs of the upper layer are removed, leaving the smooth lowland surface to the north.

Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time.

NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and developed and built the orbiter. Mission operations are conducted jointly from Lockheed Martin and from JPL, a division of the California Institute of Technology in Pasadena.

Evidence for submarine landslides and continental slope erosion related to fault reactivation during the last glaciation offshore eastern Canada

NASA Astrophysics Data System (ADS)

Saint-Ange, F.; Campbell, C.; MacKillop, K.; Mosher, D. C.; Piper, D. J.; Roger, J.

2012-12-01

Many studies have proposed that reactivation of dormant faults during deglaciation is a source of neotectonic activity in glaciated regions, but few have demonstrated the relationship to submarine landslides. In this study, seabed morphology and shallow geology of the outer continental margin adjacent to the Charlie Gibbs Fracture Zone off Newfoundland, Canada was investigated for evidence of this relationship. The glacial history and morphology of the margin suggest that the entire continental shelf in the area, coincident with major continental crustal lineaments, was ice-covered during the Last glacial cycle, and transverse troughs delineate the paleo-icestream drainage patterns. A recent investigation of Notre Dame Trough revealed the existence of large sediment failures on the shelf. The current study investigates complex seafloor erosion and widespread mass transport deposition (MTD) on the continental slope seaward of Notre Dame Trough, using recently-acquired high resolution seismic reflection data and piston cores. The new data reveal that a trough mouth fan (TMF) is present on the slope seaward of Notre Dame Trough. The Notre Dame TMF is characterized by a succession of stacked debris flows, but does not show a lobate shape in plan view like other classic TMFs. Instead, the Notre Dame TMF has abruptly-truncated margins suggesting post-depositional failure and erosion of the fan deposits. Seismic reflection data show that the locations of the failures along the TMF margin are coincident with a set of shallow faults; however the current dataset does not image the deeper portion of the faults. On the upper slope immediately south of the TMF, a narrow and deeply incised canyon is located along-trend with the Notre Dame Trough. The location of this canyon appears to be controlled by a fault. Downslope from this canyon, along the southern margin of the TMF, a 25 km wide, flat-floored, U-shaped valley was eroded into a succession of stacked MTD-filled channels. Seismic stratigraphic analysis shows that the valley developed around the same time as the adjacent TMF, however, the valley morphology and evidence for repeated slope failure suggests that the processes responsible for its formation were different than the processes that formed the nearby TMF. Age control provided from piston cores suggest that the last major slope failure that contributed to valley formation probably occurred at ~29 ka. Geotechnical measurements from piston cores show slightly underconsolidated sediments. The results indicate that this part of the margin is more unstable than Orphan Basin and Labrador slope regions. Given the low factor of safety and the complex fault system, low energy earthquake from the surrounding area could be enough to potentially trigger landslides.

Full-wave multiscale anisotropy tomography in Southern California

NASA Astrophysics Data System (ADS)

Lin, Yu-Pin; Zhao, Li; Hung, Shu-Huei

2014-12-01

Understanding the spatial variation of anisotropy in the upper mantle is important for characterizing the lithospheric deformation and mantle flow dynamics. In this study, we apply a full-wave approach to image the upper-mantle anisotropy in Southern California using 5954 SKS splitting data. Three-dimensional sensitivity kernels combined with a wavelet-based model parameterization are adopted in a multiscale inversion. Spatial resolution lengths are estimated based on a statistical resolution matrix approach, showing a finest resolution length of ~25 km in regions with densely distributed stations. The anisotropic model displays structural fabric in relation to surface geologic features such as the Salton Trough, the Transverse Ranges, and the San Andreas Fault. The depth variation of anisotropy does not suggest a lithosphere-asthenosphere decoupling. At long wavelengths, the fast directions of anisotropy are aligned with the absolute plate motion inside the Pacific and North American plates.

Bits and Pieces

NASA Technical Reports Server (NTRS)

2006-01-01

19 August 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the contact between an area of light-toned rock and an expanse of darker-toned materials on the floor of Coprates Chasma. Remnants -- bits and pieces -- of the light-toned material are scattered throughout the scene, indicating that this material once covered everything in this area. Coprates is one of several chasms that comprise the giant Valles Marineris trough system.

Location near: 13.2oS, 61.8oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Autumn

Subtropical westerly jet waveguide and winter persistent heavy rainfall in south China

NASA Astrophysics Data System (ADS)

Ding, Feng; Li, Chun

2017-07-01

Using observed daily precipitation and National Centers for Environmental Prediction-National Center for Atmospheric Research reanalysis data, what induced winter large spatial persistent heavy rainfall (PHR) events in south China was examined, based on composite analyses of 30 large spatial PHR events during 1951-2015. The results showed that wave trains within North Africa-Asia (NAA) westerly jet existed in upper troposphere during these PHR processes. The wave trains shared the characteristic of a Rossby wave. The Rossby wave originated from northwest Europe, entered into the NAA jet through strong cold air advection to form convergence over the Mediterranean, and then propagated eastward along subtropical NAA jet. The Rossby wave propagated toward Southeast Asia and caused strong divergence in the upper troposphere. The strong divergence in the upper troposphere induced vertical convection and favored large spatial PHR events in south China. In addition, the enhanced India-Burma trough and subtropical high in the northwestern Pacific supplied enough water vapor transportation. This mechanism would be useful to the medium-range forecast of such winter rainfall processes over south China.

Ocean wave electric generators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenberg, H.R.

This patent describes an apparatus for generating electricity from ocean waves. It consists of: 1.) a hollow buoyant duck positioned in the path of waves including a core about the center axis of which the duck rotates, a lower chamber portion having liquid therein and an upper chamber portion having air therein. The air is alternately compressed and expanded by the liquid in the chamber during the rotational motion of the duck caused by waves. A turbine mounted in the upper portion of the duck is driven by the compressed and expanded air. A generator is coupled to the turbinemore » and operated to produce electrical energy and an air bulb; 2.) a spine having a transverse axial shaft anchoring the spine to the ocean floor. The upper portion of the spine engages the duck to maintain the duck in position. The spine has a curved configuration to concentrate and direct wave energy. The spine configuration acts as a scoop to increase the height of wave peaks and as a foil to increase the depth of wave troughs.« less

Dabigatran Levels in Elderly Patients with Atrial Fibrillation: First Post-Marketing Experiences.

PubMed

Bolek, Tomáš; Samoš, Matej; Škorňová, Ingrid; Stančiaková, Lucia; Staško, Ján; Galajda, Peter; Kubisz, Peter; Mokáň, Marián

2018-05-08

The number of elderly individuals with non-valvular atrial fibrillation (NV-AF) requiring long-term anticoagulation is rising. The pharmacokinetics of oral anticoagulants in elderly individuals may differ from that for younger patients. The aim of this study was to assess the dabigatran levels in elderly patients with NV-AF. A pilot prospective post-marketing study in patients with NV-AF on dabigatran therapy was performed; we enrolled 21 consecutive elderly patients (aged ≥ 75 years) on a reduced dabigatran regimen (110 mg twice daily) and compared them with 13 younger (≤ 70 years) individuals on reduced dabigatran therapy due to renal impairment and with 16 younger patients on standard dabigatran therapy (150 mg twice daily). Blood samples were taken for the assessment of dabigatran trough and peak levels. Dabigatran levels were measured with the Hemoclot ® Thrombin Inhibitor Assay. There were significant differences in dabigatran trough levels when comparing elderly patients on reduced dabigatran with non-elderly patients on reduced dabigatran (99.3 ± 73.6 vs 51.6 ± 25.6 ng/mL; p < 0.01). Similarly, the detected dabigatran peak levels were significantly higher in elderly patients on reduced dabigatran compared with non-elderly patients on reduced dabigatran (173.4 ± 116.2 vs 116.1 ± 19.1 ng/mL; p < 0.01). No significant differences in dabigatran trough and peak levels were found when comparing elderly patients on reduced dabigatran with non-elderly patients on standard dabigatran therapy. This pilot study demonstrated that elderly patients on reduced dabigatran exhibit significantly higher dabigatran levels than younger individuals on a reduced regimen, and similar levels compared with younger individuals on standard dabigatran.

Geomorphic interaction among climate, sea levels and karst groundwater: the Taranto area (South of Italy)

NASA Astrophysics Data System (ADS)

Spilotro, Giuseppe; Fidelibus, Maria Dolores; Argentiero, Ilenia; Pellicani, Roberta; Parisi, Alessandro; Di Modugno, Antonella

2017-04-01

The area of Taranto (Apulia region, Italy) has an extraordinary environmental and landscape value, which derives from its specific geological, geomorphological and hydrogeological conditions: they represent the effect of a complex mechanism of interaction in the geological time among the sea, its level variations and stands driven by climate changes, karst groundwater and the geo lithological frame. The knowledge of this interaction spans over two very different time duration: the first is subsequent to the sedimentary pleistocenic deposition and diagenesis and lasts until the late Holocene; the second spans over a more limited time durations, from the LIA until today, and its knowledge is mainly based on hystorical topographic records and reports. The general geological and stratigraphical setting is represented by marine deposits, which fill the Bradanic Trough, shaped in the upper part as marine terraces bordering the W and SW side of the Murgian carbonate platform (Apulia, South of Italy) as well. This latter constitutes an important karst hydro-structure, fed by precipitation, bordered on the opposite side of the Bradanic Trough by the Adriatic Sea. Fresh groundwater hosted in the huge coastal aquifer freely flows towards the Adriatic coast, while on the opposite W-NW side, the continuous confinement by the impermeable filling of the trough, forces the underground drainage of the aquifer towards the Ionian Sea just in the Taranto area. The overall flow rate of the groundwater through submarine and subaerial coastal springs, according to the current sea level, is significant and currently estimated in about 18 m3/sec. Climate changes have forced over geological time, but also in shorter periods, sea level changes and stands, consequently correlated to groundwater levels. This allowed genesis of selected karst levels, of regional extension, both at the surface or underground, which arise as typical forms, namely polje and karst plane inland, terraces on the sea front, doline and caves near surface and underground. In the area of Taranto the changes in sea level resulted in active or fossil aquifer discharge points; the outflow areas of the aquifer into the sea are associated with specific morphologies distributed at various elevations in form of numerous elliptical sea basins or salt pan at higher elevations. A thorough geological study, accompanied by a significant number of stratigraphic and hydrogeological data, some datations, high resolution DTMs and bathymetric surveys allowed an excellent reconstruction of the geomorphological processes in the long (geological time span) term. Historical investigations allowed a significant recognition of such processes in more recent ages (starting from the Little Ice Age), reported by different levels of hydrological activities in these areas. More generally, it is possible to recognize in the study area the constraining morphogenetic power of groundwater outflow, which reveals in very characteristic morphologies, erosional basins and salt pans in the final evolution, on carbonate mainland and in the overlying marine terraces, at the elevations of the different sea level standstills. Thus, a narrow area embraces all kind of morphologies, whether those related to a still active outflow, or those in the final evolution or fossil condition, in a range of elevations varying between 60 m ASL and 40 m BSL according present knowledges.

SHARAD Radar investigations into the initiation of spiral troughs on Planum Boreum, Mars

NASA Astrophysics Data System (ADS)

Smith, I. B.; Holt, J. W.

2010-12-01

Recent evidence demonstrates that the prominent spiral troughs of the North Polar Layered Deposits (NPLD) on Mars are not young features, having persisted and evolved during accumulation of more than 500 meters of ice [Smith and Holt, Nature, 2010]. Because of the rich stratigraphy in the NPLD, determining the processes controlling trough formation and evolution is an important step in understanding the history of ice and climate on Mars. Multiple periods of trough initiation are observed in radar data collected by the Shallow Radar (SHARAD) instrument on Mars Reconnaissance Orbiter; however, the mechanism behind trough initiation is still a mystery. Discrete radar reflectors can be associated with the onset of spiral troughs because of their stratigraphic relationships: below the reflectors the troughs do not exist, and above the troughs begin to take shape. To address the question of trough formation we have mapped these reflectors, which are assumed to represent isochrones, in more than 400 SHARAD observations throughout the NPLD. Taken together these represent the surfaces where troughs initiated, i.e. surfaces that lie directly below the first appearance of troughs. When observation geometries are favorable, we find that the onset of each trough rests on a change in slope usually at the base of a buried erosional scarp. The underlying layers end abruptly at the scarps rather than diminish or pinch out with distance, suggesting that the NPLD underwent cap-wide erosion predating trough formation. This surface morphology provides the initial conditions needed to form troughs from the combination of deposition and katabatic winds affected by surface slope. Radar observations indicate that the troughs initiated and evolved with approximately the same wavelength as can be measured today. Thus proposed hypotheses of small bedforms growing into larger wavelength structures is not supported. Locally, the unconformable contact between younger, trough-related material and older eroded surfaces is exposed at the surface. Neither the younger nor older exposed layers show small-scale bedforms, supporting this conclusion. At least two initiation surfaces can be observed in the radar data within the uppermost 500 m of the NPLD. Alternating periods of erosion and deposition are predicted to result from large changes in obliquity and insolation at the Martian north pole [Laskar et al., Nature, 2004], suggesting that trough initiation may be related to orbital forcing.

Designer Troughs

NASA Image and Video Library

2006-06-11

This MOC image shows a wide, flat-floored trough flanked by several smaller, branching troughs in the Olympica Fossae region of Mars. Dark- and intermediate-toned slope streaks -- created by dry avalanches of dust -- occur on the trough walls

Optimized molten salt receivers for ultimate trough solar fields

NASA Astrophysics Data System (ADS)

Riffelmann, Klaus-J.; Richert, Timo; Kuckelkorn, Thomas

2016-05-01

Today parabolic trough collectors are the most successful concentrating solar power (CSP) technology. For the next development step new systems with increased operation temperature and new heat transfer fluids (HTF) are currently developed. Although the first power tower projects have successfully been realized, up to now there is no evidence of an all-dominant economic or technical advantage of power tower or parabolic trough. The development of parabolic trough technology towards higher performance and significant cost reduction have led to significant improvements in competitiveness. The use of molten salt instead of synthetic oil as heat transfer fluid will bring down the levelized costs of electricity (LCOE) even further while providing dispatchable energy with high capacity factors. FLABEG has developed the Ultimate TroughTM (UT) collector, jointly with sbp Sonne GmbH and supported by public funds. Due to its validated high optical accuracy, the collector is very suitable to operate efficiently at elevated temperatures up to 550 °C. SCHOTT will drive the key-innovations by introducing the 4th generation solar receiver that addresses the most significant performance and cost improvement measures. The new receivers have been completely redesigned to provide a product platform that is ready for high temperature operation up to 550 °C. Moreover distinct product features have been introduced to reduce costs and risks in solar field assembly and installation. The increased material and design challenges incurred with the high temperature operation have been reflected in sophisticated qualification and validation procedures.

The origin and peculiarities of the nigerian benue trough: Another look from recent gravity data obtained from the middle benue

NASA Astrophysics Data System (ADS)

Ajayi, C. O.; Ajakaiye, D. E.

1981-12-01

The origin of the Benue trough has been a controversial subject. Previous workers in the area have evolved several theories ranging from a rift, with or without plate tectonic concepts (King, 1950; Wright, 1968, 1970; Burke et al., 1970; Grant, 1971; Olade, 1975) to a geosyncline (Lees, 1952) and a combination of both (Cratchley and Jones, 1965; Offodile, 1976) to explain the origin of the trough. One of the aims of the gravity survey, carried out in the middle Benue and discussed in this paper, was to attempt to resolve some of the problems associated with the origin of the trough as proposed by previous workers and in so doing to explain the geological peculiarities associated with the trough. Interpretations of the gravity data along two north—south profiles in the survey area indicated the existence of a rift, of normal width (about 40 km) buried under the Cretaceous cover and located between the central axis (ridge) of the trough and the northern boundary of the trough. The gravity minimum which occurs south of the central axis of the trough, was also ascribed to another rift. Thus the Benue trough is considered to consist of two parallel rifts separated by the axial ridge which partly explains the abnormal width of the trough. The interpreted models also indicate a low-angle thrust fault, with a small displacement, which may be related to the folding of the sediments in the trough and also to the asymmetry of the trough. Furthermore, the gravity data suggest that oceanic crust might not have reached the ground surface in the Benue trough, as in the Red Sea, before rifting ceased.

Body mass index influences infliximab post-infusion levels and correlates with prospective loss of response to the drug in a cohort of inflammatory bowel disease patients under maintenance therapy with Infliximab.

PubMed

Scaldaferri, Franco; D'Ambrosio, Daria; Holleran, Grainne; Poscia, Andrea; Petito, Valentina; Lopetuso, Loris; Graziani, Cristina; Laterza, Lucrezia; Pistone, Maria Teresa; Pecere, Silvia; Currò, Diego; Gaetani, Eleonora; Armuzzi, Alessandro; Papa, Alfredo; Cammarota, Giovanni; Gasbarrini, Antonio

2017-01-01

Infliximab is an effective treatment for inflammatory bowel disease (IBD). Studies differ regarding the influence of body mass index (BMI) on the response to infliximab, with the majority of studies indicating that increased BMI may be associated with a poorer response to Infliximab. However, the pharmacokinetic mechanisms causing this have not yet been reported. Examine the correlation between BMI/immunosuppressant use with clinical response, trough and post-infusion levels of infliximab, tumour necrosis factor-α(TNF-α) and anti-drug antibodies(ATI), and determine if these factors can predict future response. We collected serum from 24 patients receiving Infliximab before and 30 minutes following infusion. Clinical parameters were collected retrospectively and prospectively. ELISA measurements of infliximab, TNF-α and ATI were performed. We confirmed that patients with higher infliximab trough levels have a better response rate and that patients with an elevated BMI display a higher rate of loss of response (20%). Patients with a higher BMI had elevated post-infusion levels of infliximab. Additionally, the ratio of IFX/TNF-α trough levels correlated with clinical response to the following infusion. This study confirms that an elevated BMI is associated with a poorer response to infliximab. For the first time, we describe that a higher BMI correlates with higher post-infusion levels, however this does not correlate with a higher rate of response to the drug, suggesting that circulating drug levels do not correlate with tissue levels. Furthermore, in our small cohort of patients, we identified a possible predictive marker of future response to treatment which may be used to guide dose escalation and predict non-response to infliximab.

Pharmacokinetics of a combined oral contraceptive in obese and normal weight women

PubMed Central

Westhoff, Carolyn L.; Torgal, Anupama H.; Mayeda, Elizabeth R.; Pike, Malcolm C.; Stanczyk, Frank Z.

2010-01-01

Background This study was conducted to compare oral contraceptive (OC) pharmacokinetics (PK) in normal weight (BMI 19.0-24.9) and obese (BMI 30.0-39.9) women. Study Design During the third week of the third cycle of OC use, we admitted 15 normal weight and 15 obese women for collection of 12 venous specimens over 24 h. Using RIA techniques, we measured levels of ethinyl estradiol (EE) and levonorgestrel (LNG). During the same cycle, women underwent twice-weekly sonography to assess ovarian follicular development and blood draws to measure endogenous estradiol (E2) and progesterone levels. Results Obese women had a lower area under the curve (AUC; 1077.2 pg*h/mL vs 1413.7 pg*h/mL) and lower maximum values (85.7 pg/mL vs 129.5 pg/mL) for EE than normal weight women (p = 0.04 and 0.01, respectively); EE trough levels were similar between BMI groups. The similar, but smaller, differences in their LNG levels for AUC and maximum values (Cmax) were not statistically significant. While peak values differed somewhat, the LNG trough levels were similar for obese and normal weight women (2.6 ng/mL and 2.5 ng/mL, respectively). Women with greater EE AUC had smaller follicular diameters (p = 0.05) and lower E2 levels (p = 0.04). While follicular diameters tended to be larger among obese women, these differences were not statistically significant. Conclusion OC hormone peak levels are lower among obese women compared to normal weight women, but their trough levels are similar. In this small study, the observed PK differences did not translate into more ovarian follicular activity among obese OC users. PMID:20472113

Seismic Stratigraphic Evidence From SE Ross Sea for Late Oligocene Glaciers and ice Streams Issuing From Marie Byrd Land

NASA Astrophysics Data System (ADS)

Sorlien, C. C.; Luyendyk, B. P.; Wilson, D. S.; Decesari, R. C.; Bartek, L. R.; Diebold, J. B.

2006-12-01

The extent of the West Antarctic ice sheet during mid-Cenozoic time is controversial and important to climate models. High-resolution multichannel seismic reflection data were acquired using the RVIB Palmer along the edge of the Ross Ice Shelf across the Eastern Basin of Ross Sea, in an area where calving of the ice shelf has exposed seafloor that has not been accessible to marine geophysics in several decades. A sub-basin in the far southeast corner of Ross Sea contains a succession of sediment-filled troughs, each capped by an unconformity. These troughs range between 2 and 20 km across, are 100 to 150 m-deep, with the narrower ones bounded by flat-topped ridges interpreted as moraines. We interpret the troughs interval to slightly predate 25 Ma. Reflections just 100 m below the troughs interval can be directly correlated to near DSDP270 where they underlie strata dated at ~25 Ma. A deeper stack of prograding sequences associated with a flat- topped ridge are interpreted as pre-25 Ma, possibly early Oligocene, deltas formed adjacent to the grounding line of a glacier, and the flat-topped ridge to be a moraine. The shallowest of the stack of unconformities capping the broad troughs can be projected across a basement ridge on trend with Roosevelt Island to a regional angular unconformity ("Red"), present across 70 km to deep sedimentary Eastern Basin. This unconformity represents about 1 km of missing stratigraphic section, is smooth and level, and splits into several major sequence boundaries within deep Eastern Basin. The second shallowest of these boundaries is dated about 14 Ma at DSDP-270. We interpret this unconformity to be cut by regional thick, grounded ice at depths several hundred meters below sea level. Pre-25 Ma strata show evidence of narrow erosional troughs and reflective mounds or ridges on the west flank of the basement ridge, but such features are not present in southern deep Eastern Basin near the ice shelf edge. This is evidence that the troughs were carved by glaciers issuing from distant highlands of Marie Byrd Land and not from East Antarctica. Late Oligocene through mid Miocene and younger prograding and unconformities farther north in Eastern Basin indicate grounded ice there. One possible interpretation is that "Red" was cut by thick, grounded ice that affected all of the Eastern Ross Sea paleo-shelf, while the pre-25 Ma glaciers affected only the area proximal to Marie Byrd Land. Late Oligocene glaciation on the outer shelf above deep Eastern Basin may have been sourced from East Antarctica and/or Central High. Evidence for pre-25 Ma glaciation proximal to Marie Byrd Land, combined with evidence for Oligocene ice caps at widely-separated localities of West Antarctica, allow the interpretation that portions of the West Antarctic Ice Sheet developed during Oligocene time. The broad troughs and the stack of prograding sequences may be related to dynamic ice caps and sea level falls in mid Oligocene and earliest Oligocene time. The Middle Miocene Red unconformity may be related to development of polar (cold-base) ice sheets. Oligocene glaciation implies that Marie Byrd Land and eastern Ross Sea have subsided from higher elevation due to cooling after late Cretaceous crustal thinning.

Transmissivity of the Upper Floridan aquifer in Florida and parts of Georgia, South Carolina, and Alabama

USGS Publications Warehouse

Kuniansky, Eve L.; Bellino, Jason C.; Dixon, Joann F.

2012-01-01

The Floridan aquifer system (FAS) covers an area of approximately 100,000 square miles in Florida and parts of Georgia, South Carolina, Alabama, and Mississippi. Groundwater wells for water supply were first drilled in the late 1800s and by the year 2000, the FAS was the primary source of drinking water for about 10 million people. One of the methods for assessing groundwater availability is the development of regional or subregional groundwater flow models of the aquifer system that can be used to develop water budgets spatially and temporally, as well as evaluate the groundwater resource change over time. Understanding the distribution of transmissivity within the FAS is critical to the development of groundwater flow models. The map presented herein differs from previously published maps of the FAS in that it is based on interpolation of 1,487 values of transmissivity. The transmissivity values in the dataset range from 8 to 9,000,000 feet squared per day (ft2/d) with the majority of the values ranging from 10,000 to 100,000 ft2/d. The wide range in transmissivity (6 orders of magnitude) is typical of carbonate rock aquifers, which are characterized by a wide range in karstification. Commonly, the range in transmissivity is greatest in areas where groundwater flow creates conduits in facies that dissolve more readily or areas of high porosity units that have interconnected vugs, with diameters greater than 0.1 foot. These are also areas where transmissivity is largest. Additionally, first magnitude springsheds and springs are shown because in these springshed areas, the estimates of transmissivity from interpolation may underestimate the actual range in transmissivity. Also shown is an area within the Gulf Trough in Georgia where high yielding wells are unlikely to be developed in the Upper Floridan aquifer. The interpolated transmissivity ranges shown on this map reflect the geologic structure and karstified areas. Transmissivity is large in the areas where the system is unconfined, such as west-central Florida and southwest Georgia just northwest of the Gulf Trough. Transmissivity is small along the Gulf Trough and Southwest Georgia Embayment (referred to as Apalachicola Embayment in some reports). Transmissivity is also small in the thin, updip part of the system near its northern boundary. Another area of large transmissivity coincides with the Southeast Georgia Embayment.

The Salton Seismic Imaging Project: Tomographic characterization of a sediment-filled rift valley and adjacent ranges, southern California

NASA Astrophysics Data System (ADS)

Davenport, K.; Hole, J. A.; Stock, J. M.; Fuis, G. S.; Carrick, E.; Tikoff, B.

2011-12-01

The Salton Trough in Southern California represents the northernmost rift of the Gulf of California extensional system. Relative motion between the Pacific and North American plates is accommodated by continental rifting in step-over zones between the San Andreas, Imperial, and Cerro Prieto transform faults. Rapid sedimentation from the Colorado River has isolated the trough from the southern portion of the Gulf of California, progressively filling the subsiding rift basin. Based on data from previous seismic surveys, the pre-existing continent has ruptured completely, and a new ~22 km thick crust has been created entirely by sedimentation overlying rift-related magmatism. The MARGINS, EarthScope, and USGS-funded Salton Seismic Imaging Project (SSIP) was designed to investigate the nature of this new crust, the ongoing process of continental rifting, and associated earthquake hazards. SSIP, acquired in March 2011, comprises 7 lines of onshore seismic refraction / wide-angle reflection data, 2 lines of refraction / reflection data in the Salton Sea, and a line of broadband stations. This presentation focuses on the refraction / wide-angle reflection line across the Imperial Valley, extending ~220 km across California from Otay Mesa, near Tijuana, to the Colorado River. The data from this line includes seventeen 100-160 kg explosive shots and receivers at 100 m spacing across the Imperial Valley to constrain the structure of the Salton Trough rift basin, including the Imperial Fault. Eight larger shots (600-920 kg) at 20-35 km spacing and receivers at 200-500 m spacing extend the line across the Peninsular Ranges and the Chocolate Mountains. These data will contrast the structure of the rift to that of the surrounding crust and provide constraints on whole-crust and uppermost mantle structure. Preliminary work has included tomographic inversion of first-arrival travel times across the Valley, emphasizing a minimum-structure approach to create a velocity model of the upper crust. Ongoing modeling provides constraints on the basin margins, showing a steeply dipping western edge of the rift valley approximately coincident to the shoreline of the ancient Lake Cahuilla. Low velocity sediments and low velocity crystalline crust within the Imperial Valley are consistent with previous studies and contrast with faster crystalline rocks near the surface outside the rift. Ongoing analysis will provide a more detailed image of upper crustal structure, as well as preliminary modeling of the entire crust.

Monitoring of seafloor crustal deformation using GPS/Acoustic technique along the Nankai Trough, Japan

NASA Astrophysics Data System (ADS)

Yasuda, K.; Tadokoro, K.; Ikuta, R.; Watanabe, T.; Fujii, C.; Matsuhiro, K.; Sayanagi, K.

2014-12-01

Seafloor crustal deformation is crucial for estimating the interplate locking at the shallow subduction zone and has been carried out at subduction margins in Japan, e.g., Japan Trench and Nankai Trough [Sato et al., 2011; Tadokoro et al., 2012]. Iinuma et al. [2012] derived slip distributions during the 2011 Tohoku-Oki earthquake using GPS/Acoustic data and on-land GPS data. The result showed that maximum slip is more than 85 m near the trench axis. The focal area along the Nankai trough extended to the trough axis affected this earthquake by cabinet office, government of Japan. 　We monitored seafloor crustal deformation along the Nankai trough, Japan. Observation regions are at the eastern end of Nankai trough (named Suruga trough) and at the central Nankai trough. We established and monitored by two sites across the trough at each region. In the Suruga trough region, we repeatedly observed from 2005 to 2013. We observed 13 and 14 times at a foot wall side (SNE) and at a hanging wall side (SNW), respectively. We estimated the displacement velocities with relative to the Amurian plate from the result of repeated observation. The estimated displacement velocity vectors at SNE and SNW are 42±8 mm/y to N94±3˚W direction and 39±11 mm/y to N84±9˚W direction, respectively. The directions are the same as those measured at the on-land GPS stations. The magnitudes of velocity vector indicate significant shortening by approximately 4 mm/y between SNW and on-land GPS stations at hanging wall side of the Suruga Trough. This result shows that the plate interface at the northernmost Suruga trough is strongly locked. In the central Nankai trough region, we established new two stations across the central Nankai trough (Both stations are about 15km distance from trough) and observed only three times, August 2013, January 2014, and June 2014. We report the results of monitoring performed in this year.

Seismic structure of the central US crust and upper mantle: Uniqueness of the Reelfoot Rift

USGS Publications Warehouse

Pollitz, Fred; Mooney, Walter D.

2014-01-01

Using seismic surface waves recorded with Earthscope's Transportable Array, we apply surface wave imaging to determine 3D seismic velocity in the crust and uppermost mantle. Our images span several Proterozoic and early Cambrian rift zones (Mid-Continent Rift, Rough Creek Graben—Rome trough, Birmingham trough, Southern Oklahoma Aulacogen, and Reelfoot Rift). While ancient rifts are generally associated with low crustal velocity because of the presence of thick sedimentary sequences, the Reelfoot Rift is unique in its association with low mantle seismic velocity. Its mantle low-velocity zone (LVZ) is exceptionally pronounced and extends down to at least 200 km depth. This LVZ is of variable width, being relatively narrow (∼50km">∼50km wide) within the northern Reelfoot Rift, which hosts the New Madrid Seismic Zone (NMSZ). We hypothesize that this mantle volume is weaker than its surroundings and that the Reelfoot Rift consequently has relatively low elastic plate thickness, which would tend to concentrate tectonic stress within this zone. No other intraplate ancient rift zone is known to be associated with such a deep mantle low-velocity anomaly, which suggests that the NMSZ is more susceptible to external stress perturbations than other ancient rift zones.

Mountains, Craters and Plains

NASA Image and Video Library

2016-03-17

New Horizons views of the informally named Sputnik Planum on Pluto (top) and the informally named Vulcan Planum on Charon (bottom). Both scale bars measure 20 miles (32 kilometers) long; illumination is from the left in both instances. The Sputnik Planum view is centered at 11°N, 180°E, and covers the bright, icy, geologically cellular plains. Here, the cells are defined by a network of interconnected troughs that crisscross these nitrogen-ice plains. At right, in the upper image, the cellular plains yield to pitted plains of southern Sputnik Planum. This observation was obtained by the Ralph/Multispectral Visible Imaging Camera (MVIC) at a resolution of 1,050 feet (320 meters) per pixel. The Vulcan Planum view in the bottom panel is centered at 4°S, 4°E, and includes the "moated mountain" Clarke Mons just above the center of the image. As well as featuring impact craters and sinuous troughs, the water ice-rich plains display a range of surface textures, from smooth and grooved at left, to pitted and hummocky at right. This observation was obtained by the Long Range Reconnaissance Imager (LORRI) at a resolution of 525 feet (160 meters) per pixel. http://photojournal.jpl.nasa.gov/catalog/PIA20535

A new simple technique for rearing F1 progeny from females of the Simulium damnosum Theobald complex.

PubMed

Raybould, J N; Barro, T; Sawadogo, R; Mordzifa, F

1982-06-01

Laboratory rearing of Simulium damnosum complex species enables female adults to be indirectly identified from their larval progeny. A simple, readily transportable rearing apparatus was developed for investigations by the Onchocerciasis Control programme by using unbreakable, easily packed and reassembled parts and by feeding the larvae at least partly with living green algae (Chlorophyceae) cultured in the laboratory. Although the larvae are sensitive to excess nitrogen compounds, the use of algae and a large volume of water obviated the need for a separate purification system in which water was circulated by an A/C electrical centrifugal pump between a container and an inclined trough in which most of the larvae developed. The rate of development was rapid giving rise to full size larvae (suitable for cytotaxonomic determination), pupae and adults. The adults were attracted into a collecting device by light. Developments to protect the larvae during electrical power failures included a slow-drying wooden rearing trough and an automatic switch to an alternative D/C power supply and pump. This technique has been in general use in O.C.P. laboratories in Benin, Ghana, Ivory Coast and Upper Volta and many thousands of larvae have been reared.

General weather conditions and precipitation contributing to the 2011 flooding in the Mississippi River and Red River of the North Basins, December 2010 through July 2011: Chapter B in 2011 floods of the central United States

USGS Publications Warehouse

Vining, Kevin C.; Chase, Katherine J.; Loss, Gina R.

2013-01-01

Excessive precipitation produced severe flooding in the Mississippi River and Red River of the North Basins during spring and summer 2011. The 2011 flooding was caused by weather conditions that were affected in part by a La Niña climate pattern. During the 2010–11 climatological winter (December 2010–February 2011), several low pressure troughs from the Rocky Mountains into the Ohio River subbasin produced large amounts of precipitation. Precipitation was above normal to record amounts in parts of the Missouri River, Red River of the North, and upper Mississippi River subbasins, and mostly normal to below normal in the Ohio River and lower Mississippi River subbasins. During the 2011 climatological spring (March–May 2011), a large low pressure trough over the continental States and a high pressure ridge centered in the vicinity of the Gulf of Mexico combined to produce storms with copious precipitation along frontal boundaries across the Central States. Rain totals recorded during the April 18–28, 2011, precipitation event were more than 8 inches at several locations, while an impressive total of 16.15 inches was recorded at Cape Girardeau, Missouri. Several locations in the Missouri River subbasin had rainfall totals that were nearly one-third to one-half of their 1971–2000 normal annual amounts during a May 16–31, 2011, precipitation event. During June and July, thunderstorm development along frontal boundaries resulted in areas of heavy rain across the Missouri River, Red River of the North, and upper Mississippi River subbasins, while rainfall in the lower Mississippi River subbasin was mostly below normal.

Large ice particles associated with small ice water content observed by AIM CIPS imagery of polar mesospheric clouds: Evidence for microphysical coupling with small-scale dynamics

NASA Astrophysics Data System (ADS)

Rusch, D.; Thomas, G.; Merkel, A.; Olivero, J.; Chandran, A.; Lumpe, J.; Carstans, J.; Randall, C.; Bailey, S.; Russell, J.

2017-09-01

Observations by the Cloud Imaging and Particle Size (CIPS) instrument on the Aeronomy of Ice in the Mesosphere (AIM) satellite have demonstrated the existence of Polar Mesospheric Cloud (PMC) regions populated by particles whose mean sizes range between 60 and 100 nm (radii of equivalent volume spheres). It is known from numerous satellite experiments that typical mean PMC particle sizes are of the order of 40-50 nm. Determination of particle size by CIPS is accomplished by measuring the scattering of solar radiation at various scattering angles at a spatial resolution of 25 km2. In this size range we find a robust anti-correlation between mean particle size and albedo. These very-large particle-low-ice (VLP-LI) clouds occur over spatially coherent areas. The surprising result is that VLP-LI are frequently present either in the troughs of gravity wave-like features or at the edges of PMC voids. We postulate that an association with gravity waves exists in the low-temperature summertime mesopause region, and illustrate the mechanism by a gravity wave simulation through use of the 2D Community Aerosol and Radiation Model for Atmospheres (CARMA). The model results are consistent with a VLP-LI population in the cold troughs of monochromatic gravity waves. In addition, we find such events in Whole Earth Community Climate Model/CARMA simulations, suggesting the possible importance of sporadic downward winds in heating the upper cloud regions. This newly-discovered association enhances our understanding of the interaction of ice microphysics with dynamical processes in the upper mesosphere.

Development and Validation of a Novel Vancomycin Dosing Nomogram for Achieving High-Target Trough Levels at 2 Canadian Teaching Hospitals

PubMed Central

Thalakada, Rosanne; Legal, Michael; Lau, Tim T Y; Luey, Tiffany; Batterink, Josh; Ensom, Mary H H

2012-01-01

Background: Recent guidelines recommend a vancomycin trough (predose) level between 15 and 20 mg/L in the treatment of invasive gram-positive infections, but most initial dosing nomograms are designed to achieve lower targets (5–15 mg/L). Clinicians need guidance about appropriate initial dosing to achieve the higher target. Objective: To develop and validate a high-target vancomycin dosing nomogram to achieve trough levels of 15–20 mg/L. Methods: A retrospective study was conducted at 2 teaching hospitals, St Paul’s Hospital and Vancouver General Hospital in Vancouver, British Columbia. Patients who were treated with vancomycin between January 2008 and June 2010 and who had achieved a trough level of 14.5–20.5 mg/L were identified. Demographic and clinical data were collected. Multiple linear regression was used to develop a vancomycin dosing nomogram for each hospital site. An integrated nomogram was constructed by merging the data from the 2 hospitals. A unique set of patients at each institution was used for validating their respective nomograms and a pooled group of patients for validating the integrated nomogram. Predictive success was evaluated, and a nomogram was deemed significantly different from another nomogram if p < 0.05 via “χ2 testing. Results: Data from 78 patients at one hospital and 91 patients at the other were used in developing the respective institutional nomograms. For each hospital’s data set, both age and initial serum creatinine were significantly associated with the predicted dosing interval (p < 0.001). Validation in a total of 105 test patients showed that the integrated nomogram had a predictive success rate of 56%. Conclusions: A novel vancomycin dosing nomogram was developed and validated at 2 Canadian teaching hospitals. This integrated nomogram is a tool that clinicians can use in selecting appropriate initial vancomycin regimens on the basis of age and serum creatinine, to achieve high-target levels of 15–20 mg/L. The nomogram should not replace clinical judgment for patients with unstable and/or reduced renal function. PMID:22783028

Upper-tropospheric environment-tropical cyclone interactions over the western North Pacific: A statistical study

NASA Astrophysics Data System (ADS)

Qian, Yu-Kun; Liang, Chang-Xia; Yuan, Zhuojian; Peng, Shiqiu; Wu, Junjie; Wang, Sihua

2016-05-01

Based on 25-year (1987-2011) tropical cyclone (TC) best track data, a statistical study was carried out to investigate the basic features of upper-tropospheric TC-environment interactions over the western North Pacific. Interaction was defined as the absolute value of eddy momentum flux convergence (EFC) exceeding 10 m s-1 d-1. Based on this definition, it was found that 18% of all six-hourly TC samples experienced interaction. Extreme interaction cases showed that EFC can reach ~120 m s-1 d-1 during the extratropical-cyclone (EC) stage, an order of magnitude larger than reported in previous studies. Composite analysis showed that positive interactions are characterized by a double-jet flow pattern, rather than the traditional trough pattern, because it is the jets that bring in large EFC from the upper-level environment to the TC center. The role of the outflow jet is also enhanced by relatively low inertial stability, as compared to the inflow jet. Among several environmental factors, it was found that extremely large EFC is usually accompanied by high inertial stability, low SST and strong vertical wind shear (VWS). Thus, the positive effect of EFC is cancelled by their negative effects. Only those samples during the EC stage, whose intensities were less dependent on VWS and the underlying SST, could survive in extremely large EFC environments, or even re-intensify. For classical TCs (not in the EC stage), it was found that environments with a moderate EFC value generally below ~25 m s-1 d-1 are more favorable for a TC's intensification than those with extremely large EFC.

Influence of low-level resistance to vancomycin on efficacy of teicoplanin and vancomycin for treatment of experimental endocarditis due to Enterococcus faecium.

PubMed Central

Fantin, B; Leclercq, R; Arthur, M; Duval, J; Carbon, C

1991-01-01

Emergence of vancomycin-resistant strains among enterococci raises a new clinical challenge. Rabbits with aortic endocarditis were infected with Enterococcus faecium BM4172, a clinical strain resistant to low levels of vancomycin (MIC, 16 micrograms/ml) and susceptible to teicoplanin (MIC, 1 micrograms/ml), and against its susceptible variant E. faecium BM4172S obtained in vitro by insertional mutagenesis (MICs, 2 and 0.5 micrograms/ml, respectively). Control animals retained 8 to 10.5 log10 CFU/g of vegetation. We evaluated in this model the efficacy of vancomycin (30 mg/kg of body weight; mean peak and trough serum levels, 27 and 5 micrograms/ml, respectively), teicoplanin (standard dose, 10 mg/kg; mean peak and trough levels, 23 and 9 micrograms/ml, respectively; and high dose, 20 mg/kg; mean peak and trough levels, 63 and 25 micrograms/ml, respectively), gentamicin (6 mg/kg; mean peak and trough levels, 8.6 and less than 0.1 micrograms/ml, respectively), alone or in combination, given every 12 h intramuscularly for 5 days. Teicoplanin standard dose was as active as vancomycin against both strains. Vancomycin was not effective against E. faecium BM4172 but was highly effective against E. faecium BM4172S (7.5 +/- 1.1 log10 CFU/g of vegetation versus 4.9 +/- 1.0 log10 CFU/g of vegetation for vancomycin against E. faecium BM4172 and E. faecium BM4172S, respectively; P = 0.0012). A high dose of teicoplanin was more effective than vancomycin against E. faecium BM4172 (4.4 +/- 1.8 log10 CFU/g of vegetation versus 7.5 +/- 1.1 log10 CFU/g of vegetation for teicoplanin high dose and vancomycin, respectively; P less than 0.05). Against E. faecium BM4172 glycopeptide-gentamicin combinations were the most effective regimens in vitro and in vivo (2.8 +/- 0.7 and 3.5 +/- 1.3 log10 CFU/g of vegetation for vancomycin plus gentamicin and teicoplanin standard dose plus gentamicin, respectively; P < 0.05 versus single-drug regimens). We concluded that high-dose teicoplanin or the combination of a glycopeptide antibiotic plus gentamicin was effective against experimental infection due to E. faecium with low-level resistance to vancomycin. PMID:1834013

Are Vancomycin Trough Concentrations of 15 to 20 mg/L Associated With Increased Attainment of an AUC/MIC ≥ 400 in Patients With Presumed MRSA Infection?

PubMed

Hale, Cory M; Seabury, Robert W; Steele, Jeffrey M; Darko, William; Miller, Christopher D

2017-06-01

To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ≥400. A retrospective analysis was conducted among vancomycin-treated adult patients with a positive methicillin-resistant Staphylococcus aureus (MRSA) culture. Attainment of a calculated AUC/MIC ≥400 was compared between patients with troughs in the reference range of 15 to 20 mg/L and those with troughs in the following ranges: <10, 10 to 14.9, and >20 mg/L. Nephrotoxicity was assessed as a secondary outcome based on corrected average vancomycin troughs over 10 days of treatment. Overall, 226 patients were reviewed and 100 included. Relative to troughs ≥10, patients with vancomycin troughs <10 mg/L were 73% less likely to attain an AUC/MIC ≥400 (odds ratio [OR] 0.27, 95% confidence interval [CI]: 0.01-0.75). No difference was found in the attainment of an AUC/MIC ≥400 in patients with troughs of 10 to 14.9 mg/L and >20 mg/L when compared to patients with troughs of 15 to 20 mg/L. The mean corrected average vancomycin trough was higher in patients developing nephrotoxicity compared to those who did not (19.5 vs 14.5 mg/L, P < .001). Achieving vancomycin serum trough concentrations of 15 to 20 mg/L did not result in an increased attainment of the AUC/MIC target relative to troughs of 10 to 14.9 mg/L but may increase nephrotoxicity risk.

Structural framework, stratigraphy, and petroleum geology of the area of oil and gas lease Sale No. 49 on the U.S. Atlantic continental shelf and slope

USGS Publications Warehouse

Mattick, Robert E.; Hennessy, Jacqueline L.

1980-01-01

On September 23, 1977, the U.S. Department of the Interior announced the tentative selection of 136 tracts for Sale No. 49 of oil and gas leases in the Baltimore Canyon Trough on the U.S. Atlantic Continental Shelf and Slope. This report summarizes the geology and petroleum potential of the area. The Baltimore Canyon Trough is an elongate, seaward-opening sedimentary basin filled by as much as 14 km of Mesozoic and Cenozoic sedimentary rocks. The basin first formed under the New Jersey shelf and gradually spread west and south as the area subsided after the rifting that formed the Atlantic basin. Rocks of the Triassic and Jurassic Systems together are more than 8 km thick in a depocenter areally restricted to the northern part of the trough. Basal Jurassic rocks are apparently nonmarine sedimentary rocks bedded with evaporite deposits. Direct evidence that some salt is in the basal Jurassic section comes from the Houston Oil and Minerals 676-1 well, which penetrated salt at a depth of about 3.8 km. During the Middle and Late Jurassic, more open marine conditions prevailed than in the Early Jurassic, and carbonate banks and reefs formed discontinuously along the seaward side of the shelf. Sand flats likely occupied the central part of the shelf, and these probably graded shoreward into nonmarine red beds that accumulated in a bordering coastal plain. Thick nonmarine sands and silty shales of Late Jurassic age were deposited in what is now the nearshore and midshelf area. These sedimentary rocks probably grade into thick marine carbonate rocks near the present shelf edge. During the Cretaceous, less sediment accumulated (about 4 km) than during the Jurassic, and most was deposited during Early Cretaceous time. The Cretaceous units show two main trends through time-a diminishing rate of sediment accumulation and an increase in marine character of sediments. During the Middle and Late Cretaceous, calcareous sand and mud filled the basin, buried the shelf-edge reefs and later spilled across the reefs into the oceanic basin as worldwide sea level reached a maximum. Cenozoic deposits are spread over the present shelf and adjacent Coastal Plain in overlapping sheets of marine and nonmarine sediment. The maximum thickness (1.5 km) is along the outer part of the present shelf. Major tectonic deformation in the Baltimore Canyon Trough area appears to have terminated near the end of the Early Cretaceous, when at least one large mafic intrusion (Great Stone dome) was emplaced. Upper Cretaceous sedimentary rocks are arched above older uplifted fault blocks near the shelf edge; this arching may be the result of draping due to differential compaction or, perhaps, minor movement of the fault blocks during Late Cretaceous time. The dominance of terrestrial over marine-derived organic matter in sediment samples from the COST No. B-2 well indicates that economic amounts of liquid petroleum hydrocarbons were probably not generated in the area but suggests a high potential for generation of wet or dry gas. Supporting evidence for the presence of natural-gas deposits on the slope comes from AMCOR 6021, the upper 305 m of which penetrated sediments that contained methane, ethane, and propane. Texaco, Inc., has announced that its 598-1 well yielded nearly 479,000 m s of natural gas per day from two zones during early testing. Further indication of possible gas deposits comes from analyzing the amplitude (bright spots) of seismic data. Geochemical studies of the COST No. B-2 well have shown that the shelf area of the Baltimore Canyon Trough has a relatively low geothermal gradient today and that it apparently has had a gradient as low or even lower throughout the Cretaceous to Holocene. A controversy exists concerning the maturity of the basal sediments penetrated by the COST No. B-2 well. Although significant amounts of gaseous hydrocarbons may have been generated, large amounts of liquid petroleum hydrocarbons probably hav

Safety and tolerability of deferasirox in pediatric hematopoietic stem cell transplant recipients: one facility's five years' experience of chelation treatment.

PubMed

Maximova, Natalia; Gregori, Massimo; Simeone, Roberto; Sonzogni, Aurelio; Boz, Giulia; Fucile, Carmen; Marini, Valeria; Martelli, Antonietta; Mattioli, Francesca

2017-09-08

42 pediatric patients with iron overload, who underwent liver biopsy and DFX treatment after hematopoietic stem cell transplantation were included in the study group. The patients were divided into two groups diversified according to deferasirox trough plasma concentrations (DFX C trough ) with cut-off equal to10 mcg/mL. The average dose of DFX was 25.9 mg/kg in the DFX C trough < 10 mcg/mL group versus 19.2 mg/kg in the DFX C trough > 10 mcg/mL group ( p =0,0003). The mean duration of DFX treatment was 135.7 days in the DFX C trough < 10 mcg/mL group versus 41.8 days in the DFX C trough > 10 mcg/mL group ( p <0.0001). The mean tissue iron concentration in the DFX C trough < 10 mcg/mL group was 261.9 μmol/g versus 133.4 μmol/g in the DFX C trough > 10 mcg/mL group ( p < 0.0001). 21 patients (100%) in the DFX C trough > 10 mcg/mL group had ductopenia which was complete in 47.6% of them and severe in 52.4%. All patients with particularly high C trough (> 25 mcg/mL) were found to have total ductopenia. 90.5% of all deferasirox-related adverse events and 100% of major adverse events occurred in the DFX C trough > 10 mcg/mL group. In the DFX C trough < 10 mcg/mL group only one patient interrupted chelation therapy versus 16 (84.2%) patients in the DFX C trough > 10 mcg/mL group. We would recommend a close monitoring in pediatric hematopoietic transplant recipients subjected to deferasirox-based therapy because we have observed a high incidence of adverse events and discontinuation of chelation treatment.

Conversion from twice-daily tacrolimus to once-daily extended release tacrolimus (LCPT): the phase III randomized MELT trial.

PubMed

Bunnapradist, S; Ciechanowski, K; West-Thielke, P; Mulgaonkar, S; Rostaing, L; Vasudev, B; Budde, K

2013-03-01

Phase III noninferiority trial examining efficacy and safety of converting stable renal transplant recipients from twice-daily tacrolimus to a novel extended-release once-daily tacrolimus formulation (LCPT) with a controlled agglomeration technology. Controls maintained tacrolimus twice daily. The primary efficacy endpoint was proportion of patients with efficacy failures (death, graft failure, locally read biopsy-proven acute rejection [BPAR], or loss to follow-up) within 12 months. Starting LCPT dose was 30% lower (15% for blacks) than preconversion tacrolimus dose; target trough levels were 4-15 ng/mL. A total of 326 patients were randomized; the mITT population (n = 162 each group) was similar demographically in the two groups. Mean daily dose of LCPT was significantly (p < 0.0001) lower than preconversion tacrolimus dose at each visit; mean trough levels between groups were similar. There were four efficacy failures in each group; safety outcomes were similar between groups. Frequency of premature study drug discontinuation was LCPT: 12% versus tacrolimus twice daily: 5% (p = 0.028). LCPT demonstrated noninferiority to tacrolimus twice daily in efficacy failure rates. LCPT may offer a safe and effective alternative for converting patients to a once-daily formulation. Compared to currently available tacrolimus formulation, LCPT requires lower doses to achieve target trough levels. © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.

Tectonic controls of a backarc trough-fill turbidite system: The Pliocene Tamugigawa Formation in the Niigata Shin'etsu inverted rift basin, Northern Fossa Magna, central Japan

NASA Astrophysics Data System (ADS)

Takano, Osamu; Tateishi, Masaaki; Endo, Masataka

2005-05-01

The Pliocene Tamugigawa Formation in the Niigata-Shin'etsu inverted rift basin, Northern Fossa Magna, located in the junction zone of the NE and SW Japan arcs, demonstrates a trough-fill turbidite system, which is topographically controlled in depositional style and shows notable contrasts in depositional architecture from sandy radial-fan-type turbidite systems. The Tamugigawa trough-fill turbidite system shows an elongated morphology parallel to the basin extent and facies associations consisting of trough-fill, lateral-supply and trough-side elements. The trough-fill elements comprise thick-bedded sheet sandstone and sheet-flow turbidite associations, which show sheet-like sedimentation configuration, instead of depositional lobes, without distinct upward fining and coarsening successions. The lateral-supply elements form an intra-trough small fan along a lateral sediment-supply system into the troughs, and consist mainly of coarser-grained distributary-channel fills and sheet sandstones. The trough-side elements consist of slope-mudstone and spillover associations, which were deposited on the structural highs beside the troughs. The Tamugigawa trough-fill turbidites were deposited through three phases: (a) initial ponding stage with thick, sheet sandstones provided by the lateral-supply system, (b) main filling stage with sheet-flow turbidites provided by the longitudinal supply system, and (c) filled-up stage characterized by minor-scale channel-levee systems. Basin-wide tectono-sedimentary studies reveal that the trough-fill turbidites were characteristically formed during the compressional-stress-field stage related to basin inversion. The compressional stress induced basin-floor syndepositional folding and coarse clastic supply from the uplifted provenance, resulting in topographically restricted turbidite deposition within the troughs. In contrast, turbidites of the post-rift stage, prior to basin inversion, show no topographical control because of the simple and wide rift-basin topography, relative to the amount of sediment supply. It is concluded that the trough-fill turbidites of the Niigata-Shin'etsu basin have been strongly affected by basin tectonics in their depositional architecture and formation phases.

The Effect of Age and Weight on Vancomycin Serum Trough Concentrations in Pediatric Patients

PubMed Central

Madigan, Theresa; Sieve, Ronald M.; Graner, Kevin K.; Banerjee, Ritu

2013-01-01

Background Vancomycin treatment failure has been associated with low serum vancomycin trough concentrations, prompting recommendations to increase the daily doses in adults and children. Despite more aggressive vancomycin dosing, there continues to be significant variability in vancomycin trough concentrations in pediatric patients. Methods To determine if vancomycin trough concentrations in pediatric patients differ by age and weight, we reviewed records of hospitalized patients who received vancomycin between 2008 and 2012. Patients were divided into groups that received vancomycin 40 mg/kg/day (2008 to 2009) or 60 mg/kg/day (2010 to 2012). Vancomycin trough concentrations were compared between groups and within the 60-mg/kg/day group, stratified by patient age and weight. Results After increasing the vancomycin dose from 40 mg/kg/day to 60 mg/kg/day, initial trough concentrations increased significantly in patients younger than 2 and greater than 6 years of age, but not in patients between the ages of 2 and 5 years. In the 60-mg/kg/day group, only 16.7% of patients between 2 and 5 years of age had initial trough concentrations in the therapeutic range (10 mcg/mL to 20 mcg/mL). Initial trough concentrations were therapeutic in a greater proportion of patients ages 6 years to 12 years (38.7%) and 13 years to 18 years (63.0%). Patients between the ages of 13 and 18 had the highest proportion of supratherapeutic initial vancomycin trough concentrations (14.8%). Patients weighing > 50 kg had significantly higher trough concentrations than patients ≤ 50 kg (17.1 mcg/mL vs. 9.3 mcg/mL; p<0.001). Conclusion Although increasing the vancomycin dose from 40 mg/kg/day to 60 mg/kg/day led to a significant increase in vancomycin trough concentrations, a large proportion of patients receiving 60 mg/kg/day of vancomycin had trough concentrations outside of the therapeutic range. Specifically, patients younger than 6 years tend to have low trough concentrations, while adolescents and children > 50 kg are more likely to have elevated trough concentrations. Vancomycin dosing strategies in pediatric patients should consider age and weight as well as renal function and indication. PMID:23864541

Notes on the availability of mid-Atlantic multichannel seismic reflection profiles 11 and 12-A, -B, -C, and -D

USGS Publications Warehouse

Schlee, John Stevens

1978-01-01

Available are two multichannel profiles collected by Digicon Geophysical Corporation in 1975 using a 48-channel streamer (3600 m long). and a 27.9 cu. liter air gun array. They were processed in Denver on the Phoenix "I" by William C. Patterson. The processing included demultiplexing and resampling, geometry and common-depth-point definition, velocity analysis, noise muting, band-pass filtering, time-variant filtering, time-variant deconvolution, and automatic gain control (AGC) scaling, prior to the final profile playout.The release includes parts of two lines off the mid-atlantic continental margin (see map) over the Baltimore Canyon trough. These profiles were collected as part of a regional grid over the offshore Atlantic sedimentary basins, as a part of a continuing program to assess the resource potential using non-proprietary data Line 11 is a cross shelf profile (233 ken long) taken across the shelf, slope and upper rise off Virginia (southern Baltimore Canyon trough). Line 12 (shotpoint 1Ol- 6011, parts A, 8, C and D) is an along-the-shelf profiler and stretches from the Cape Hatteras IPOD line to line 2, at the northern part of the Baltimore Canyon trough), a distance of 591 km.These profiles may be viewed at the U.S. Geological Survey, Atlantic Gulf of Mexico, Office of Marine Geology, Quissett campus, Building B, Woods Hole, Massachusetts 02543, and at the U.S. Geological Survey, Branch of Oil and Gas Resources, Denver Federal Center, Building 25, Denver. Colorado 80225. Copies of the profiles can be purchased from the Nations Geophysical and Solar-Terrestrial Data Center, Environmental Data Service- NOAA, Code D621 Boulder, Colorado 80303.

Geochemical constraints on the origin of high-Mg andesites in the southernmost Okinawa Trough

NASA Astrophysics Data System (ADS)

Chu, C.; Chung, S.; Shinjo, R.; Gallet, S.; Wang, S.; Chen, C.

2007-12-01

The Okinawa Trough, extending from SW Kyushu to NE Taiwan, is a backarc basin of the Ryukyu arc-trench system due to subduction of the Philippine Sea plate under the Eurasian plate. The southernmost part of the Okinawa Trough (SPOT), however, does not situate in a simple backarc setting but is an embryonic rift zone in which early arc volcanism takes place. Kueishantao that consists mainly of andesitic flows dated to be ~7000 yr old is an emerged volcanic islet thus formed in SPOT. Here we report whole-rock major and trace element, and Sr-Nd-Pb-Hf isotope compositions of the Kueishantao andesites. Some of the samples have unexpectedly high magnesium, with MgO ≥ 5 wt.% and Mg# > 0.5, relative to their silica contents (SiO2 ~ 60 wt.%), so can be coined as high-Mg andesites (HMAs). These HMAs display enrichments in Cs, Rb, Ba, Th, U, LREE and Pb, and depletions in HFSE, in the incompatible element variation diagram. Their overall geochemical compositions are similar to those of the mean continental crust proposed by Rudnick and Fountain (1995). The HMAs have uniform radiogenic isotope ratios, with low ÕɛNd (-4.3 to -5.0), low ÕɛHf (-0.9 to -2.4), and high 87Sr/86Sr (~0.706) and 206Pb/204Pb (~18.75). In contrast to previous notion that calls for significant contamination of upper continental crust in the magma chamber, we propose the Kueishantao HMAs to have resulted from partial melting of the subducted sediments and altered Philippine Sea crust followed by melt-mantle interaction in the mantle wedge. This interpretation is consistent with seismic tomographic results under the SPOT region marking with a combination of collision/extension/subduction tectonic context off NE Taiwan.

Integration of TerraSAR-X, RapidEye and airborne lidar for remote sensing of intertidal bedforms on the upper flats of Norderney (German Wadden Sea)

NASA Astrophysics Data System (ADS)

Adolph, Winny; Jung, Richard; Schmidt, Alena; Ehlers, Manfred; Heipke, Christian; Bartholomä, Alexander; Farke, Hubert

2017-04-01

The Wadden Sea is a large coastal transition area adjoining the southern North Sea uniting ecological key functions with an important role in coastal protection. The region is strictly protected by EU directives and national law and is a UNESCO World Heritage Site, requiring frequent quality assessments and regular monitoring. In 2014 an intertidal bedform area characterised by alternating crests and water-covered troughs on the tidal flats of the island of Norderney (German Wadden Sea sector) was chosen to test different remote sensing methods for habitat mapping: airborne lidar, satellite-based radar (TerraSAR-X) and electro-optical sensors (RapidEye). The results revealed that, although sensitive to different surface qualities, all sensors were able to image the bedforms. A digital terrain model generated from the lidar data shows crests and slopes of the bedforms with high geometric accuracy in the centimetre range, but high costs limit the operation area. TerraSAR-X data enabled identifying the positions of the bedforms reflecting the residual water in the troughs also with a high resolution of up to 1.1 m, but with larger footprints and much higher temporal availability. RapidEye data are sensitive to differences in sediment moisture employed to identify crest areas, slopes and troughs, with high spatial coverage but the lowest resolution (6.5 m). Monitoring concepts may differ in their remote sensing requirements regarding areal coverage, spatial and temporal resolution, sensitivity and geometric accuracy. Also financial budgets limit the selection of sensors. Thus, combining differing assets into an integrated concept of remote sensing contributes to solving these issues.

LWD lithostratigraphy, physical properties and correlations across tectonic domains at the NanTroSEIZE drilling transect, Nankai Trough subduction zone, Japan

NASA Astrophysics Data System (ADS)

Tudge, J.; Webb, S. I.; Tobin, H. J.

2013-12-01

Since 2007 the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) has drilled a total of 15 sites across the Nankai Trough subduction zone, including two sites on the incoming sediments of the Philippine Sea plate (PSP). Logging-while-drilling (LWD) data was acquired at 11 of these sites encompassing the forearc Kumano Basin, upper accretionary prism, toe region and input sites. Each of these tectonic domains is investigated for changes in physical properties and LWD characteristics, and this work fully integrates a large data set acquired over multiple years and IODP expeditions, most recently Expedition 338. Using the available logging-while-drilling data, primarily consisting of gamma ray, resistivity and sonic velocity, a log-based lithostratigraphy is developed at each site and integrated with the core, across the entire NanTroSEIZE transect. In addition to simple LWD characterization, the use of Iterative Non-hierarchical Cluster Analysis (INCA) on the sites with the full suite of LWD data clearly differentiates the unaltered forearc and slope basin sediments from the deformed sediments of the accretionary prism, suggesting the LWD is susceptible to the subtle changes in the physical properties between the tectonic domains. This differentiation is used to guide the development of tectonic-domain specific physical properties relationships. One of the most important physical property relationships between is the p-wave velocity and porosity. To fully characterize the character and properties of each tectonic domain we develop new velocity-porosity relationships for each domain found across the NanTroSEIZE transect. This allows the porosity of each domain to be characterized on the seismic scale and the resulting implications for porosity and pore pressure estimates across the plate interface fault zone.

Visualization of Green's Function Anomalies for Megathrust Source in Nankai Trough by Reciprocity Method

NASA Astrophysics Data System (ADS)

Petukhin, A.; Miyakoshi, K.; Tsurugi, M.; Kawase, H.; Kamae, K.

2014-12-01

Effect of various areas (asperities or SMGA) in the source of a megathrust subduction zone earthquake on the simulated long-period ground motions is studied. For this case study we employed a source fault model proposed by HERP (2012) for future M9-class event in the Nankai trough. Velocity structure is 3-D JIVSM model developed for long-period ground motion simulations. The target site OSKH02 "Konohana" is located in center of the Osaka basin. Green's functions for large number of sub-sources (>1000) were calculated by FDM using the reciprocity approach. Depths, strike and dip angles of sub-sources are adjusted to the shape of upper boundary of the Philippine Sea plate. The target period range is 4-20sec. Strongly nonuniform distribution of peak amplitudes of Green's functions is observed (see Figure), and two areas have anomalously large amplitudes: (1) a large along-strike elongated area just south of Kii peninsula and (2) a similar area south of Kii peninsula but shifted toward the Nankai trough. Elongation of the first anomaly fits well 10-15km isolines of the depth distribution of the Philippine Sea plate, while target site is located in the direction perpendicular to these isolines. For this reason, preliminarily we suppose that plate shape may have critical effect on the simulated ground motions, via a cumulative effect of sub-source radiation patterns and specific strike and dip angle distributions. Analysis of the time delay of the peak arrivals at OKSH02 demonstrates that Green's functions from the second anomaly, located in shallow part of plate boundary, are mostly composed of surface waves.

Origin and emplacement of impactites in the Chesapeake Bay impact structure, Virginia, USA

USGS Publications Warehouse

Horton, J. Wright; Gohn, G.S.; Powars, D.S.; Edwards, L.E.

2007-01-01

The late Eocene Chesapeake Bay impact structure, located on the Atlantic margin of Virginia, may be Earth's best-preserved large impact structure formed in a shallow marine, siliciclastic, continental-shelf environment. It has the form of an inverted sombrero in which a central crater ???40 km in diameter is surrounded by a shallower brim, the annular trough, that extends the diameter to ???85 km. The annular trough is interpreted to have formed largely by the collapse and mobilization of weak sediments. Crystalline-clast suevite, found only in the central crater, contains clasts and blocks of shocked gneiss that likely were derived from the fragmentation of the central-uplift basement. The suevite and entrained megablocks are interpreted to have formed from impact-melt particles and crystalline-rock debris that never left the central crater, rather than as a fallback deposit. Impact-modified sediments in the annular trough include megablocks of Cretaceous nonmarine sediment disrupted by faults, fluidized sands, fractured clays, and mixed-sediment intercalations. These impact-modified sediments could have formed by a combination of processes, including ejection into and mixing of sediments in the water column, rarefaction-induced fragmentation and clastic injection, liquefaction and fluidization of sand in response to acoustic-wave vibrations, gravitational collapse, and inward lateral spreading. The Exmore beds, which blanket the entire crater and nearby areas, consist of a lower diamicton member overlain by an upper stratified member. They are interpreted as unstratified ocean-resurge deposits, having depositional cycles that may represent stages of inward resurge or outward anti-resurge flow, overlain by stratified fallout of suspended sediment from the water column. ?? 2008 The Geological Society of America. All rights reserved.

Role of ground ice dynamics and ecological feedbacks in recent ice wedge degradation and stabilization

USGS Publications Warehouse

Mark Torre Jorgenson,; Mikhail Kanevskiy,; Yuri Shur,; Natalia Moskalenko,; Dana Brown,; Wickland, Kimberly P.; Striegl, Robert G.; Koch, Joshua C.

2015-01-01

Ground ice is abundant in the upper permafrost throughout the Arctic and fundamentally affects terrain responses to climate warming. Ice wedges, which form near the surface and are the dominant type of massive ice in the Arctic, are particularly vulnerable to warming. Yet processes controlling ice wedge degradation and stabilization are poorly understood. Here we quantified ice wedge volume and degradation rates, compared ground ice characteristics and thermal regimes across a sequence of five degradation and stabilization stages and evaluated biophysical feedbacks controlling permafrost stability near Prudhoe Bay, Alaska. Mean ice wedge volume in the top 3 m of permafrost was 21%. Imagery from 1949 to 2012 showed thermokarst extent (area of water-filled troughs) was relatively small from 1949 (0.9%) to 1988 (1.5%), abruptly increased by 2004 (6.3%) and increased slightly by 2012 (7.5%). Mean annual surface temperatures varied by 4.9°C among degradation and stabilization stages and by 9.9°C from polygon center to deep lake bottom. Mean thicknesses of the active layer, ice-poor transient layer, ice-rich intermediate layer, thermokarst cave ice, and wedge ice varied substantially among stages. In early stages, thaw settlement caused water to impound in thermokarst troughs, creating positive feedbacks that increased net radiation, soil heat flux, and soil temperatures. Plant growth and organic matter accumulation in the degraded troughs provided negative feedbacks that allowed ground ice to aggrade and heave the surface, thus reducing surface water depth and soil temperatures in later stages. The ground ice dynamics and ecological feedbacks greatly complicate efforts to assess permafrost responses to climate change.

Role of ground ice dynamics and ecological feedbacks in recent ice wedge degradation and stabilization

NASA Astrophysics Data System (ADS)

Jorgenson, M. T.; Kanevskiy, M.; Shur, Y.; Moskalenko, N.; Brown, D. R. N.; Wickland, K.; Striegl, R.; Koch, J.

2015-11-01

Ground ice is abundant in the upper permafrost throughout the Arctic and fundamentally affects terrain responses to climate warming. Ice wedges, which form near the surface and are the dominant type of massive ice in the Arctic, are particularly vulnerable to warming. Yet processes controlling ice wedge degradation and stabilization are poorly understood. Here we quantified ice wedge volume and degradation rates, compared ground ice characteristics and thermal regimes across a sequence of five degradation and stabilization stages and evaluated biophysical feedbacks controlling permafrost stability near Prudhoe Bay, Alaska. Mean ice wedge volume in the top 3 m of permafrost was 21%. Imagery from 1949 to 2012 showed thermokarst extent (area of water-filled troughs) was relatively small from 1949 (0.9%) to 1988 (1.5%), abruptly increased by 2004 (6.3%) and increased slightly by 2012 (7.5%). Mean annual surface temperatures varied by 4.9°C among degradation and stabilization stages and by 9.9°C from polygon center to deep lake bottom. Mean thicknesses of the active layer, ice-poor transient layer, ice-rich intermediate layer, thermokarst cave ice, and wedge ice varied substantially among stages. In early stages, thaw settlement caused water to impound in thermokarst troughs, creating positive feedbacks that increased net radiation, soil heat flux, and soil temperatures. Plant growth and organic matter accumulation in the degraded troughs provided negative feedbacks that allowed ground ice to aggrade and heave the surface, thus reducing surface water depth and soil temperatures in later stages. The ground ice dynamics and ecological feedbacks greatly complicate efforts to assess permafrost responses to climate change.

Interplay between climatic and tectonic processes in the St. Elias foreland, southern Alaska: Evolution of a glaciated convergent margin since the mid-Pleistocene

NASA Astrophysics Data System (ADS)

Worthington, L. L.; Gulick, S. P.; Ridgway, K. R.; Jaeger, J. M.; Cowan, E. A.; Slagle, A. L.; Forwick, M.

2013-12-01

The offshore St. Elias fold-thrust belt records the complex interaction between collisional tectonics and glacial climate variability, providing insight for models of orogenesis and the evolution of glacial depocenters. Ongoing collision of the Yakutat (YAK) microplate with North America (NA) has driven orogenesis of the St. Elias Mountains and the advance of the offshore deformation front to the southeast. Glacial erosion and deposition have provided sediment that constructed the upper continental shelf, much of which has been reincorporated into the orogenic wedge through offshore faulting and folding. We integrate core and downhole logging data from IODP Expedition 341 (Sites U1420 and U1421) drilled on the Yakutat shelf and slope with high-resolution and regional seismic profiles to investigate the coupled structural and stratigraphic evolution of the St. Elias margin. Site U1420 lies on the Yakutat shelf within the Bering Trough, a shelf-crossing trough that is within primary depocenter for Bering Glacier sediments. The sub-seafloor architecture of the Bering Trough region is defined by a regional unconformity that marks the first glacial advance to the shelf edge. Below the unconformity, the shelf is constructed by multiple aggradational packages that are likely a series of pro-glacial outer shelf/slope fans. Two faults underlie the glacial packages and have been rendered inactive as the depositional environment has evolved, while faulting elsewhere on the shelf has initiated. Site U1421 lies on the current continental slope, within the backlimb of an active thrust that forms part of the modern YAK-NA deformation front. At each of these sites, we recovered glacigenic diamict (at depths up to ~1015 m at Site U1420), all of which is younger than 0.781 Ma. Preliminary age models for the Bering Trough region indicate that the entire outer shelf and shelf edge environment have been built since the Mid-Pleistocene Transition (MPT), and is possibly even younger. In stark contrast to previous interpretations, the shelf environment, in addition to the proximal deep-sea fan system, appears to be a primary glacial depocenter since the MPT, with an average accumulation rate >1.3 mm/yr. Additionally, initiation of active deformation away from the Bering Trough depocenter likely occurred since ~1 Ma. These observations suggest that possible tectonic reorganization due to mass redistribution by glacial processes occurs at time scales on the order of 100kyr-1Myr. It follows that the St. Elias orogenic system may be more sensitive to glacial-interglacial cycles than previously recognized.

Cracked Mars

NASA Technical Reports Server (NTRS)

2006-01-01

25 June 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows v-shaped troughs in the Hephaestus Fossae region of Mars. Light-toned, windblown ripples reside in the very lowest parts of the troughs, as well as on the cratered upland outside the troughs. Boulders and other types of debris, which were derived from the layered rock exposed near the top of the troughs, are seen resting on the trough floors and perched on the sloping trough walls.

Location near: 21.1oN, 236.7oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Spring

Predicting the neurobehavioral side effects of dexamethasone in pediatric acute lymphoblastic leukemia.

PubMed

Warris, Lidewij T; van den Akker, Erica L T; Aarsen, Femke K; Bierings, Marc B; van den Bos, Cor; Tissing, Wim J E; Sassen, Sebastiaan D T; Veening, Margreet A; Zwaan, Christian M; Pieters, Rob; van den Heuvel-Eibrink, Marry M

2016-10-01

Although dexamethasone is an effective treatment for acute lymphoblastic leukemia (ALL), it can induce a variety of serious neurobehavioral side effects. We hypothesized that these side effects are influenced by glucocorticoid sensitivity at the tissue level. We therefore prospectively studied whether we could predict the occurrence of these side effects using the very low-dose dexamethasone suppression test (DST) or by measuring trough levels of dexamethasone. Fifty pediatric patients (3-16 years of age) with acute lymphoblastic leukemia (ALL) were initially included during the maintenance phase (with dexamethasone) of the Dutch ALL treatment protocol. As a marker of glucocorticoid sensitivity, the salivary very low-dose DST was used. A post-dexamethasone cortisol level <2.0nmol/L was considered a hypersensitive response. The neurobehavioral endpoints consisted of questionnaires regarding psychosocial and sleeping problems administered before and during the course of dexamethasone (6mg/m(2)), and dexamethasone trough levels were measured during dexamethasone treatment. Patients with a hypersensitive response to dexamethasone had more behavioral problems (N=11), sleeping problems, and/or somnolence (N=12) (P<0.05 for all three endpoints). The positive predictive values of the DST for psychosocial problems and sleeping problems were 50% and 30%, respectively. Dexamethasone levels were not associated with neurobehavioral side effects. We conclude that neither the very low-dose DST nor measuring dexamethasone trough levels can accurately predict dexamethasone-induced neurobehavioral side effects. However, patients with glucocorticoid hypersensitivity experienced significantly more symptoms associated with dexamethasone-induced depression. Future studies should elucidate further the mechanisms by which neurobehavioral side effects are influenced by glucocorticoid sensitivity. Copyright © 2016 Elsevier Ltd. All rights reserved.

Stationary nonimaging concentrator as a second stage element in tracking systems

NASA Astrophysics Data System (ADS)

Kritchman, E. M.; Snail, K. A.; Ogallagher, J.; Winston, R.

1983-01-01

An increase in the concentration in line focus solar concentrators is shown to be available using an evacuated compound parabolic concentrator (CPC) tube as a second stage element. The absorber is integrated into an evacuated tube with a transparent upper section and a reflective lower section, with a selective coating on the absorber surface. The overall concentration is calculated in consideration of a parabolic mirror in a trough configuration, a flat Fresnel lens over the top, or a color and coma corrected Fresnel lens. The resulting apparatus is noted to also suppress thermal losses due to conduction, convection, and IR radiation.

Forecasting and Related Problems in China

DTIC Science & Technology

1944-12-01

tsoüghs, thoiar .&*ia$«5».ej? _- or lack of effeet la , hot thereby decreased. 5me ©«istenca of such Hutap troughs has 1*34 tö srueh dl^cüjssioä -of...8217 of all frontal systeais., surface or upper, in Isdia. la v%m of. 4h£ - recexefe trend to reclaasify the so-roo-tied %oatorr, disturbances* into...f*«’ö«*"oKfc?ö{»..-d3^:’ . tection is liiaiied to ^Ttgr jnse-.^;-- ör dUTlA0 p.’Stm’r:-* Xt Iv.c vvf.!&. .fctflii !&M there i« ä frequent las

Solar photovoltaic reflective trough collection structure

DOEpatents

Anderson, Benjamin J.; Sweatt, William C.; Okandan, Murat; Nielson, Gregory N.

2015-11-19

A photovoltaic (PV) solar concentration structure having at least two troughs encapsulated in a rectangular parallelepiped optical plastic structure, with the troughs filled with an optical plastic material, the troughs each having a reflective internal surface and approximately parabolic geometry, and the troughs each including photovoltaic cells situated so that light impinging on the optical plastic material will be concentrated onto the photovoltaic cells. Multiple structures can be connected to provide a solar photovoltaic collection system that provides portable, efficient, low-cost electrical power.

Large‐scale heavy precipitation over central Europe and the role of atmospheric cyclone track types

PubMed Central

Lexer, Annemarie; Homann, Markus; Blöschl, Günter

2017-01-01

ABSTRACT Precipitation patterns over Europe are largely controlled by atmospheric cyclones embedded in the general circulation of the mid‐latitudes. This study evaluates the climatologic features of precipitation for selected regions in central Europe with respect to cyclone track types for 1959–2015, focusing on large‐scale heavy precipitation. The analysis suggests that each of the cyclone track types is connected to a specific pattern of the upper level atmospheric flow, usually characterized by a major trough located over Europe. A dominant upper level cut‐off low (COL) is found over Europe for strong continental (CON) and van Bebber's type (Vb) cyclones which move from the east and southeast into central Europe. Strong Vb cyclones revealed the longest residence times, mainly due to circular propagation paths. The central European cyclone precipitation climate can largely be explained by seasonal track‐type frequency and cyclone intensity; however, additional factors are needed to explain a secondary precipitation maximum in early autumn. The occurrence of large precipitation totals for track events is strongly related to the track type and the region, with the highest value of 45% of all Vb cyclones connected to heavy precipitation in summer over the Czech Republic and eastern Austria. In western Germany, Atlantic winter cyclones are most relevant for heavy precipitation. The analysis of the top 50 precipitation events revealed an outstanding heavy precipitation period from 2006 to 2011 in the Czech Republic, but no gradual long‐term change. The findings help better understand spatio‐temporal variability of heavy precipitation in the context of floods and may be used for evaluating climate models.

Interannual variability and predictability over the Arabian Penuinsula Winter monsoon region

NASA Astrophysics Data System (ADS)

Adnan Abid, Muhammad; Kucharski, Fred; Almazroui, Mansour; Kang, In-Sik

2016-04-01

Interannual winter rainfall variability and its predictability are analysed over the Arabian Peninsula region by using observed and hindcast datasets from the state-of-the-art European Centre for Medium-Range Weather Forecasts (ECMWF) seasonal prediction System 4 for the period 1981-2010. An Arabian winter monsoon index (AWMI) is defined to highlight the Arabian Peninsula as the most representative region for the Northern Hemispheric winter dominating the summer rainfall. The observations show that the rainfall variability is relatively large over the northeast of the Arabian Peninsula. The correlation coefficient between the Nino3.4 index and rainfall in this region is 0.33, suggesting potentially some modest predictability, and indicating that El Nino increases and La Nina decreases the rainfall. Regression analysis shows that upper-level cyclonic circulation anomalies that are forced by El Nino Southern Oscillation (ENSO) are responsible for the winter rainfall anomalies over the Arabian region. The stronger (weaker) mean transient-eddy activity related to the upper-level trough induced by the warm (cold) sea-surface temperatures during El Nino (La Nina) tends to increase (decrease) the rainfall in the region. The model hindcast dataset reproduces the ENSO-rainfall connection. The seasonal mean predictability of the northeast Arabian rainfall index is 0.35. It is shown that the noise variance is larger than the signal over the Arabian Peninsula region, which tends to limit the prediction skill. The potential predictability is generally increased in ENSO years and is, in particular, larger during La Nina compared to El Nino years in the region. Furthermore, central Pacific ENSO events and ENSO events with weak signals in the Indian Ocean tend to increase predictability over the Arabian region.

Late Cretaceous and Paleogene sedimentation along east side of San Joaquin basin, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reid, S.A.

1986-04-01

Depositional systems of the Late Cretaceous contrast with those of the Paleogene in the subsurface along the east side of the San Joaquin basin between Bakersfield and Fresno, California. Upper Cretaceous deposits include thick fan-delta and submarine fan facies of the Moreno and Panoche Formations, whereas the paleogene contains extensive nearshore, shelf, slope, and submarine fan deposits of the Lodo, Domengine, and Kreyenhagen Formations. These sediments were deposited on a basement surface having several west-trending ridges and valleys. West-flowing streams draining an ancestral Sierra Nevada of moderate relief formed prograding fan deltas that filled the valleys with thick wedges ofmore » nonmarine channel deposits, creating a bajada along the shoreline. Detrital material moved rapidly from the shoreline through a narrow shelf, into a complex of submarine fans in the subduction trough. During the early Eocene, a low sea level stand plus an end of Sierra Nevada uplift resulted in the erosion of the range to a peneplain. Stream-fed fan deltas were replaced by a major river system, which flowed west on about the present course of the Kern River. Following a rapid sea level increase, sand from the river system was deposited on the now broad shelf along a wide belt roughly coincident with California Highway 99. The river was also the point source for sand in a submarine fan northwest of Bakersfield. Both Upper Cretaceous and Paleogene depositional systems probably continue north along the east edge of the Great Valley. This proposed scenario for the east side of the San Joaquin is analogous to forearc deposits in the San Diego area, including the Cretaceous Rosario fan-delta and submarine fan system and the Eocene La Jolla and Poway nearshore, shelf, and submarine fan systems.« less

Concentrating Solar Power Projects - Gansu Akesai 50MW Molten Salt Trough

Science.gov Websites

project | Concentrating Solar Power | NREL Gansu Akesai 50MW Molten Salt Trough project Status . Technology: Parabolic trough Turbine Capacity: Net: 50.0 MW Gross: 50.0 MW Status: Under development Do you have more information, corrections, or comments? Background Technology: Parabolic trough Status: Under

Paleocene Pacific Plate reorganization mirrored in formation of the Suvarov Trough, Manihiki Plateau

NASA Astrophysics Data System (ADS)

Pietsch, Ricarda; Uenzelmann-Neben, Gabriele

2016-10-01

The Suvarov Trough is a graben structure that deviates from the Danger Islands Troughs within the Manihiki Plateau, a Large Igneous Province (LIP) located in the Central Pacific. New high-resolution seismic reflection data provide evidence that the graben formed in two phases during the Paleocene (65-45 Ma). In a first phase extension occurred in southwestward direction, pulling apart the northern part of the Suvarov Trough and a parallel trending unnamed trough. In a second phase a change of extensional force direction occurred from southwest to west-northwest, forming the southern part of the Suvarov Trough that extends onto the High Plateau. The formation of the Suvarov Trough is accompanied by a series of normal fault systems that apparently formed simultaneously. Comparing the seismic results to existing Pacific paleo strain reconstructions, the timing of increased strain and local deformation direction fits well to our findings. We thus suggest that the multiple strike directions of the Suvarov Trough represent an extensional structure that was caused by the major, stepwise Pacific Plate reorganization during the Paleocene.

The 2010 Pakistan Flood and Russian Heat Wave: Teleconnection of Hydrometeorological Extremes

NASA Technical Reports Server (NTRS)

Lau, William K. M.; Kim, Kyu-Myong

2012-01-01

In this paper, preliminary results are presented showing that the two record-setting extreme events during 2010 summer (i.e., the Russian heat wave-wildfires and Pakistan flood) were physically connected. It is found that the Russian heat wave was associated with the development of an extraordinarily strong and prolonged extratropical atmospheric blocking event in association with the excitation of a large-scale atmospheric Rossby wave train spanning western Russia, Kazakhstan, and the northwestern China-Tibetan Plateau region. The southward penetration of upper-level vorticity perturbations in the leading trough of the Rossby wave was instrumental in triggering anomalously heavy rain events over northern Pakistan and vicinity in mid- to late July. Also shown are evidences that the Russian heat wave was amplified by a positive feedback through changes in surface energy fluxes between the atmospheric blocking pattern and an underlying extensive land region with below-normal soil moisture. The Pakistan heavy rain events were amplified and sustained by strong anomalous southeasterly flow along the Himalayan foothills and abundant moisture transport from the Bay of Bengal in connection with the northward propagation of the monsoonal intraseasonal oscillation.

Kinetic energy budget during strong jet stream activity over the eastern United States

NASA Technical Reports Server (NTRS)

Fuelberg, H. E.; Scoggins, J. R.

1980-01-01

Kinetic energy budgets are computed during a cold air outbreak in association with strong jet stream activity over the eastern United States. The period is characterized by large generation of kinetic energy due to cross-contour flow. Horizontal export and dissipation of energy to subgrid scales of motion constitute the important energy sinks. Rawinsonde data at 3 and 6 h intervals during a 36 h period are used in the analysis and reveal that energy fluctuations on a time scale of less than 12 h are generally small even though the overall energy balance does change considerably during the period in conjunction with an upper level trough which moves through the region. An error analysis of the energy budget terms suggests that this major change in the budget is not due to random errors in the input data but is caused by the changing synoptic situation. The study illustrates the need to consider the time and space scales of associated weather phenomena in interpreting energy budgets obtained through use of higher frequency data.

LCOE reduction potential of parabolic trough and solar tower CSP technology until 2025

NASA Astrophysics Data System (ADS)

Dieckmann, Simon; Dersch, Jürgen; Giuliano, Stefano; Puppe, Michael; Lüpfert, Eckhard; Hennecke, Klaus; Pitz-Paal, Robert; Taylor, Michael; Ralon, Pablo

2017-06-01

Concentrating Solar Power (CSP), with an installed capacity of 4.9 GW by 2015, is a young technology compared to other renewable power generation technologies. A limited number of plants and installed capacity in a small challenging market environment make reliable and transparent cost data for CSP difficult to obtain. The International Renewable Energy Agency (IRENA) and the DLR German Aerospace Center gathered and evaluated available cost data from various sources for this publication in order to yield transparent, reliable and up-to-date cost data for a set of reference parabolic trough and solar tower plants in the year 2015 [1]. Each component of the power plant is analyzed for future technical innovations and cost reduction potential based on current R&D activities, ongoing commercial developments and growth in market scale. The derived levelized cost of electricity (LCOE) for 2015 and 2025 are finally contrasted with published power purchase agreements (PPA) of the NOOR II+III power plants in Morocco. At 7.5% weighted average cost of capital (WACC) and 25 years economic life time, the levelized costs of electricity for plants with 7.5 (trough) respectively 9 (tower) full-load hours thermal storage capacity decrease from 14-15 -ct/kWh today to 9-10 -ct/kWh by 2025 for both technologies at direct normal irradiation of 2500 kWh/(m².a). The capacity factor increases from 41.1% to 44.6% for troughs and from 45.5% to 49.0% for towers. Financing conditions are a major cost driver and offer potential for further cost reduction with the maturity of the technology and low interest rates (6-7 - ct/kWh for 2% WACC at 2500 kWh/(m2.a) in 2025).

Observations of Convectively Coupled Kelvin Waves forced by Extratropical Wave Activity

NASA Astrophysics Data System (ADS)

Kiladis, G. N.; Biello, J. A.; Straub, K. H.

2012-12-01

It is well established by observations that deep tropical convection can in certain situations be forced by extratropical Rossby wave activity. Such interactions are a well-known feature of regions of upper level westerly flow, and in particular where westerlies and equatorward wave guiding by the basic state occur at low enough latitudes to interact with tropical and subtropical moisture sources. In these regions convection is commonly initiated ahead of upper level troughs, characteristic of forcing by quasi-geostrophic dynamics. However, recent observational evidence indicates that extratropical wave activity is also associated with equatorial convection even in regions where there is a "critical line" to Rossby wave propagation at upper levels, that is, where the zonal phase speed of the wave is equal to the zonal flow speed. A common manifestation of this type of interaction involves the initiation of convectively coupled Kelvin waves, as well as mixed Rossby-gravity (MRG) waves. These waves are responsible for a large portion of the convective variability within the ITCZ over the Indian, Pacific, and Atlantic sectors, as well as within the Amazon Basin of South America. For example, Kelvin waves originating within the western Pacific ITCZ are often triggered by Rossby wave activity propagating into the Australasian region from the South Indian Ocean extratropics. At other times, Kelvin waves are seen to originate along the eastern slope of the Andes. In the latter case the initial forcing is sometimes linked to a low-level "pressure surge," initiated by wave activity propagating equatorward from the South Pacific storm track. In yet other cases, such as over Africa, the forcing appears to be related to wave activity in the extratropics which is not necessarily propagating into low latitudes, but appears to "project" onto the Kelvin structure, in line with past theoretical and modeling studies. Observational evidence for extratropical forcing of Kelvin and MRG waves will be presented, and the seasonality of these statistical associations will be discussed. Extratropical forcing of equatorial waves appears to be most efficient during the solstice seasons by waves originating within the winter hemisphere and interacting with convection in the summer hemisphere. A companion presentation by J. Biello will examine the theoretical basis for these interactions.

Mantle Upwellings Below the Ibero-Maghrebian Region with a Common Deep Source from P Travel-time Tomography

NASA Astrophysics Data System (ADS)

Civiero, C.; Custodio, S.; Silveira, G. M.; Rawlinson, N.; Arroucau, P.

2017-12-01

The processes responsible for the geodynamical evolution of the Ibero-Maghrebian domain are still enigmatic. Several geophysical studies have improved our understanding of the region, but no single model has been accepted yet. This study takes advantage of the dense station networks deployed from France in the north to Canary Islands and Morocco in the south to provide a new high-resolution P-wave velocity model of the structure of the upper-mantle and top of the lower mantle. These images show subvertical small-scale upwellings below Atlas Range, Canary Islands and Central Iberia that seem to cross the transition zone. The results, together with geochemical evidence and a comparison with previous global tomographic models, reveal the ponding or flow of deep-plume material beneath the transition zone, which seems to feed upper-mantle "secondary" pulses. In the upper mantle the plumes, in conjunction with the subduction-related upwellings, allow the hot mantle to rise in the surrounding zones. During its rising, the mantle interacts with horizontal SW slab-driven flow which skirts the Alboran slab and connects with the mantle upwelling below Massif Central through the Valencia Trough rift.

3D Vp heterogeneity beneath the Marmara Sea: Shot tomography on a 2D OBS array

NASA Astrophysics Data System (ADS)

Bayrakci, Gaye; Laigle, Mireille; Bécel, Anne; Hirn, Alfred; Taymaz, Tuncay; Yolsal-Ćevikbilen, Seda

2010-05-01

After the 1999 Izmit and Duzce earthquakes, the multi-method SEISMARMARA seismic survey has been carried out with the aim to constrain the seismogenic part of the North Anatolian Fault (NAF) immersed into the Marmara Sea. During this survey, a network of 35 3-components Japanese Ocean Bottom Seismometers (OBS) placed on a 2D grid and land stations have recorded the current seismic activity for a period of 6 weeks and 2000 km of MCS profiles shot in the North Marmara Trough (NMT). In the present study the first arrival times of artificial sources are inverted with the well known local earthquake tomography (LET) code Simulps in order to approach the 3D upper-crustal heterogeneity which then could be implemented as initial model easily and without any loss of information into a joint inversion of the local earthquake data and shots. The 3D upper-crustal P-wave velocity heterogeneity of the North Marmara Trough (NMT) is derived by inverting a set of 16000 first arrival times of artificial sources. We have checked the sensitivity of the results to the grid geometry, the control parameters and the 1D initial velocity model. Due to a huge basement depth variation between the NMT rims and the trough itself, we have then designed a 3D a priori model by taking into account the sea-floor depth and the topographic trend of the basement. This 3D initial model allowed to include the shots recorded by 5 land stations into the inverted data set and to improve the image resolution at the borders of NMT. It allowed also to have a denser inversion grid which is needed for constraining the small wave-length heterogeneity of the Marmara Sea. The artefacts which may be due to the very large perturbations with respect to the 1D initial model were avoided with the use of this 3D initial model. The reliability of the results are validated by synthetic tests and by the comparison with the seismic reflection and refraction profiles which principal characteristics such as the sedimentary infill and basement geometry are remarkably recovered by the inversion in the well resolved regions. This study provides an unprecedented 3D view of the sedimentary thicknesses and of the basement topography which shows large vertical throws which may reach up to 7 km. It reveals also the variations of more than 2 km of the basement topography in a distance of 5 km along the sea-bottom trace of the North Anatolian Fault and its basins. The consideration of the 3D sedimentary thickness and of such basement topography is crucial for accurate relocation of the earthquakes by taking into account the 3D heterogeneity of both, upper-crustal P and S wave velocities. This 3D structure may find also further applications like in modeling studies for the evolution and the present activity of the Marmara Sea's features.

Evaluation of the trough-type rain gage

Treesearch

Irvin C. Reigner

1964-01-01

Although infrequently used, the trough-type rain gage has been described as aerodynamically the most efficient of gages (Hayes and Kittredge 1949). This applies only to the commercial semicircular eave-gutter type of trough and not to troughs rectangular in cross-section. The latter, as well as the upright cylindrical type of gage, produces greater disturbances in the...

Performance of coagulation tests in patients on therapeutic doses of rivaroxaban. A cross-sectional pharmacodynamic study based on peak and trough plasma levels.

PubMed

Francart, Suzanne J; Hawes, Emily M; Deal, Allison M; Adcock, Dorothy M; Gosselin, Robert; Jeanneret, Cheryl; Friedman, Kenneth D; Moll, Stephan

2014-06-01

Knowledge of anticoagulation status during rivaroxaban therapy is desirable in certain clinical situations. It was the study objective to determine coagulation tests most useful for assessing rivaroxaban's anticoagulant effect. Peak and trough blood samples from 29 patients taking rivaroxaban 20 mg daily were collected. Mass spectrometry and various coagulation assays were performed. "On-therapy range" was defined as the rivaroxaban concentrations determined by LC-MS/MS. A "misprediction percentage" was calculated based on how often results of each coagulation assay were in the normal reference range, while the rivaroxaban concentration was in the "on-therapy" range. The on-therapy range was 8.9-660 ng/ml. The misprediction percentages for prothrombin time (PT) and activated partial thromboplastin time (aPTT), using multiple reagents and coagulometers, ranged from 10%-52% and 31%-59%, respectively. PT, aPTT and activated clotting time (ACT) were insensitive to trough rivaroxaban: 59%, 62%, and 80% of samples had a normal result, respectively. Over 95% of PT and ACT values were elevated at peak. Four different rivaroxaban calibrated anti-Xa assays had R² values >0.98, demonstrating strong correlations with rivaroxaban drug levels. In conclusion, PT, aPTT and ACT are often normal in patients on therapeutic doses of rivaroxaban. However, PT and ACT may have clinical utility at higher drug plasma levels. Rivaroxaban calibrated anti-factor Xa assays can accurately identify low and high on-therapy rivaroxaban drug levels and, therefore, have superior utility in all clinical situations where assessment of anticoagulation status may be beneficial.

A Pilot Randomized Controlled Trial to Promote Immunosuppressant Adherence in Adult Kidney Transplant Recipients.

PubMed

Cukor, Daniel; Ver Halen, Nisha; Pencille, Melissa; Tedla, Fasika; Salifu, Moro

2017-01-01

Nonadherence to immunosuppressant medication is a prevalent practice among kidney transplant recipients and has been associated with increased risk for graft failure and economic burden. The aim of this pilot study was to test whether a culturally sensitive cognitive-behavioral adherence promotion program could significantly improve medication adherence to tacrolimus prescription as measured by telephone pill counts among kidney transplant recipients. Thirty-three adult transplant recipients were less than 98% adherent to tacrolimus prescription based on 3 telephone pill counts and were randomized either to the 2-session cognitive-behavioral adherence promotion program or to standard care. The curriculum was developed from an iterative process with transplant recipients into a 2-session group program that provided psychoeducation, addressed barriers to adherence, fostered motivation to improve adherence behavior, and discussed cultural messages on adherence behavior. The intervention group displayed significantly higher levels of adherence when compared to the control group (t = 2.2, p = 0.04) and. similarly, when the amount of change was compared between the groups, the intervention group showed more change than the control condition (F (22,1) = 12.005, p = 0.003). Tacrolimus trough concentration levels were used as a secondary measure of adherence and, while there were no significant between-group differences for mean trough concentration levels, the variability in the trough levels did significantly decrease over time indicating more consistent pill-taking behavior in the intervention group. There is preliminary support for the pilot program as a successful intervention in helping patients with their immunosuppressant medication. © 2016 S. Karger AG, Basel.

Variability of Late-Night Salivary Cortisol in Cushing Disease: A Prospective Study.

PubMed

Sandouk, Zahrae; Johnston, Philip; Bunch, Dustin; Wang, Sihe; Bena, James; Hamrahian, Amir; Kennedy, Laurence

2018-03-01

The frequency of variable hormonogenesis in patients with Cushing disease (CD) but without cyclical symptoms is unclear. To assess the frequency of variable hormonogenesis in patients presenting with CD. Over a 6-month period, patients with confirmed or suspected CD provided late-night salivary samples for up to 42 consecutive nights. Of 19 patients confirmed to have CD, 16 provided at least 7 consecutive salivary samples, and 13 provided at least 21; these 16 patients are the subjects of this report. Twelve patients had at least three peak and two trough levels of late-night salivary cortisol (LNSC) but in only two patients were strict criteria for cyclical hormonogenesis fulfilled; variation was assessed as random in the others. Eight patients had de novo CD, and eight had recurrent/persistent disease. All patients with recurrent/persistent CD had two or more normal results, and in four of these patients, >50% of LNSC were normal. In six patients with de novo disease with at least one normal LNSC level, the maximum levels ranged from 1.55 to 15.5 times the upper limit of normal. Extreme fluctuations of cortisol production, measured by sequential LNSC, are common in CD. In newly diagnosed disease, this may only occasionally impair diagnostic ability, whereas in most patients with recurrent/persistent disease after pituitary surgery, LNSC is frequently within the reference range, with potential to cause diagnostic problems.

A Numerical Study of Hurricane Erin (2001). Part 1; Model Verification and Storm Evolution

NASA Technical Reports Server (NTRS)

Wu, Liquang; Braun, Scott A.; Halverson, J.; Heymsfield, G.

2003-01-01

The Pennsylvania State University-National Center for Atmospheric Research mesoscale model MM5 is used to simulate Hurricane Erin (2001) at high resolution (4-km spacing) from its early development as a tropical depression on 7 September 2001, through a period of rapid intensification into a strong hurricane (8-9 September), and finally into a stage during which it maintains its intensity on 10 September. These three stages of development, intensification, and maintenance in the simulation are in good agreement with the observed evolution of Erin. The simulation shows that during the development and early portions of the intensification stages, intensification is favored because the environmental wind shear is weak and the system moves over a warm tongue of water. As Erin intensifies, the wind'shear gradually increases with the approach of an upper-level trough and strengthening of a low-level high pressure system. By 10 September, the wind shear peaks and begins to decrease, the storm moves over slightly cooler waters, and the intensification ends. Important structural changes occur at this time as the outer precipitation shift from the northeastern and eastern sides to the western side of the eye and precipitation begins to surround the entire eye to initiate the development of a secondary wind maximum and an outer eyewall. The simulation is used to investigate the role of vertical wind shear in the changes of the precipitation structure that took place between 9-10 September by examining the effects of both storm-relative flow changes and changes in the shear-induced tilt. Qualitative agreement is found between the divergence pattern and advection of vorticity by the relative flow with convergence (divergence) generally associated with asymmetric inflow (outflow) in the eyewall region. The shift in the outer precipitation is consistent with a shift in the low-level relative inflow from the northeastern to the northwestern side of the storm. The changes in the relative flow are associated with changes in the winds as the hurricane moves relative to the upper tough and the low-level high pressure system. Examination of the shear-induced tilt of the vortex shows that the change in the tilt direction is greater than that of the shear direction as the tilt shifts from a northerly orientation to northwesterly. Consistent with theory for adiabatic vortices, the maximum low-level convergence and upper-level divergence (and the maximum upward motion) occurs in the direction of tilt. Consequently, both mechanisms may play roles in the changes in the precipitation pattern.

Relationship Between FEV1 and Patient-Reported Outcomes Changes: Results of a Meta-Analysis of Randomized Trials in Stable COPD.

PubMed

de la Loge, Christine; Tugaut, Béatrice; Fofana, Fatoumata; Lambert, Jérémy; Hennig, Michael; Tschiesner, Uta; Vahdati-Bolouri, Mitra; Segun Ismaila, Afisi; Suresh Punekar, Yogesh

2016-03-15

Background: This meta-analysis assessed the relationship between change from baseline (CFB) in spirometric measurements (trough forced expiratory volume in 1 second [FEV 1 ] and FEV 1 area under the curve [AUC]) and patient-reported outcomes (St. George's Respiratory Questionnaire total score [SGRQ] CFB, Transition Dyspnea Index [TDI] and exacerbation rates) after 6-12 months' follow-up, using study treatment-group level data. Methods: A systematic literature search was performed for randomized controlled trials of ≥24 weeks duration in adults with chronic obstructive pulmonary disease (COPD). Studies reporting ≥1 spirometric measurement and ≥1 patient-reported outcome (PRO) at baseline and at study endpoint were selected. The relationships between PROs and spirometric endpoints were assessed using Pearson correlation coefficient and meta-regression. Results: Fifty-two studies (62,385 patients) were included. Primary weighted analysis conducted at the last assessment showed a large significant negative correlation (r, -0.68 [95% confidence interval (CI); -0.77, -0.57]) between trough FEV 1 and SGRQ. Improvement of 100 mL in trough FEV 1 corresponded to a 5.9 point reduction in SGRQ. Similarly, a reduction of 4 points on SGRQ corresponded to 40 mL improvement in trough FEV 1 ( p <0.001). The weighted correlation coefficients of trough FEV 1 with TDI, exacerbation rate (all) and exacerbation rate (moderate/severe) at last assessment point were 0.57, -0.69 and -0.57, respectively (all p <0.05). For the analyses excluding placebo groups, the correlations of FEV 1 with SGRQ and TDI were lower but significant. Conclusions: A strong association exists between changes in spirometric measurements and changes in PROs.

Nationwide conversion to generic tacrolimus in pediatric kidney transplant recipients.

PubMed

Naicker, Derisha; Reed, Peter W; Ronaldson, Jane; Kara, Tonya; Wong, William; Prestidge, Chanel

2017-11-01

Bioequivalence between Tacrolimus Prograf® and generic tacrolimus formulations has been demonstrated in adult populations, however clinical experience and safety data regarding generic tacrolimus in pediatric transplant recipients is limited. This study aimed to evaluate conversion from Tacrolimus Prograf® to Sandoz® in pediatric renal transplant recipients nationwide. The primary outcome was a change in mean trough tacrolimus concentration. Additionally, changes in tacrolimus intra-patient coefficient of variation (CoV), allograft function, requirement for dose adjustments, and episodes of biopsy-proven rejection were evaluated. Retrospective cohort study in 37 pediatric renal transplant recipients who switched to Tacrolimus Sandoz®. Each patient had three pre-conversion tacrolimus trough and creatinine concentrations within the 4 months prior and three post-conversion concentrations on day 3, 10, and the next subsequent level. Mean pre- and post-conversion tacrolimus trough concentrations and glomerular filtration rate (eGFR) were calculated. Tacrolimus concentration, CoV, and creatinine differences were compared by paired t test. Thirty-seven patients (41% females, age 3-18 years) were included. Average intra-patient difference in trough tacrolimus concentration was 0.05μg/l (95% CI -0.37 to 0.47). Average intra-patient difference in eGFR was -1.20 ml/min/1.73 2 (95% CI -3.53 to 1.13). Three patients had acute rejection during 12 months post-conversion compared to none during 12 months pre-conversion. Pediatric renal transplant recipients can be converted from Tacrolimus Prograf® to Sandoz® with negligible change in trough concentration, dose adjustments, or immediate allograft function. Of concern was the number of acute rejection episodes, however non-adherence contributed to at least one episode and this difference was determined clinically and statistically not significant.

Relationship Between FEV1 and Patient-Reported Outcomes Changes: Results of a Meta-Analysis of Randomized Trials in Stable COPD

PubMed Central

de la Loge, Christine; Tugaut, Béatrice; Fofana, Fatoumata; Lambert, Jérémy; Hennig, Michael; Tschiesner, Uta; Vahdati-Bolouri, Mitra; Segun Ismaila, Afisi; Suresh Punekar, Yogesh

2016-01-01

Background: This meta-analysis assessed the relationship between change from baseline (CFB) in spirometric measurements (trough forced expiratory volume in 1 second [FEV1] and FEV1 area under the curve [AUC]) and patient-reported outcomes (St. George’s Respiratory Questionnaire total score [SGRQ] CFB, Transition Dyspnea Index [TDI] and exacerbation rates) after 6-12 months’ follow-up, using study treatment-group level data. Methods: A systematic literature search was performed for randomized controlled trials of ≥24 weeks duration in adults with chronic obstructive pulmonary disease (COPD). Studies reporting ≥1 spirometric measurement and ≥1 patient-reported outcome (PRO) at baseline and at study endpoint were selected. The relationships between PROs and spirometric endpoints were assessed using Pearson correlation coefficient and meta-regression. Results: Fifty-two studies (62,385 patients) were included. Primary weighted analysis conducted at the last assessment showed a large significant negative correlation (r, −0.68 [95% confidence interval (CI); −0.77, −0.57]) between trough FEV1 and SGRQ. Improvement of 100 mL in trough FEV1 corresponded to a 5.9 point reduction in SGRQ. Similarly, a reduction of 4 points on SGRQ corresponded to 40 mL improvement in trough FEV1 (p<0.001). The weighted correlation coefficients of trough FEV1 with TDI, exacerbation rate (all) and exacerbation rate (moderate/severe) at last assessment point were 0.57, -0.69 and -0.57, respectively (all p<0.05). For the analyses excluding placebo groups, the correlations of FEV1 with SGRQ and TDI were lower but significant. Conclusions: A strong association exists between changes in spirometric measurements and changes in PROs. PMID:28848877

Effect of azilsartan versus candesartan on morning blood pressure surges in Japanese patients with essential hypertension

PubMed Central

Kario, Kazuomi; Enya, Kazuaki; Sugiura, Kenkichi; Ikeda, Yoshinori

2014-01-01

Morning blood pressure (BP) surge is reported as a risk factor for cardiovascular events and end-organ damage independent of the 24-h BP level. Controlling morning BP surge is therefore important to help prevent onset of cardiovascular disease. We compared the efficacy of azilsartan and candesartan in controlling morning systolic BP (SBP) surges by analyzing relevant ambulatory BP monitoring data in patients with/without baseline BP surges. As part of a 16-week randomized, double-blind study of azilsartan (20–40 mg once daily) and candesartan (8–12 mg once daily) in Japanese patients with essential hypertension, an exploratory analysis was carried out using ambulatory BP monitoring at baseline and week 14. The effects of study drugs on morning BP surges, including sleep trough surge (early morning SBP minus the lowest night-time SBP) and prewaking surge (early morning SBP minus SBP before awakening), were evaluated. Patients with sleep trough surge of at least 35 mmHg were defined by the presence of a morning BP surge (the ‘surge group’). Sleep trough surge and prewaking surge data were available at both baseline and week 14 in 548 patients, 147 of whom (azilsartan 76; candesartan 71) had a baseline morning BP surge. In surge group patients, azilsartan significantly reduced both the sleep trough surge and the prewaking surge at week 14 compared with candesartan (least squares means of the between-group differences −5.8 mmHg, P=0.0395; and −5.7 mmHg, P=0.0228, respectively). Once-daily azilsartan improved sleep trough surge and prewaking surge to a greater extent than candesartan in Japanese patients with grade I–II essential hypertension. PMID:24710336

Effect of azilsartan versus candesartan on morning blood pressure surges in Japanese patients with essential hypertension.

PubMed

Rakugi, Hiromi; Kario, Kazuomi; Enya, Kazuaki; Sugiura, Kenkichi; Ikeda, Yoshinori

2014-06-01

Morning blood pressure (BP) surge is reported as a risk factor for cardiovascular events and end-organ damage independent of the 24-h BP level. Controlling morning BP surge is therefore important to help prevent onset of cardiovascular disease. We compared the efficacy of azilsartan and candesartan in controlling morning systolic BP (SBP) surges by analyzing relevant ambulatory BP monitoring data in patients with/without baseline BP surges. As part of a 16-week randomized, double-blind study of azilsartan (20-40 mg once daily) and candesartan (8-12 mg once daily) in Japanese patients with essential hypertension, an exploratory analysis was carried out using ambulatory BP monitoring at baseline and week 14. The effects of study drugs on morning BP surges, including sleep trough surge (early morning SBP minus the lowest night-time SBP) and prewaking surge (early morning SBP minus SBP before awakening), were evaluated. Patients with sleep trough surge of at least 35 mmHg were defined by the presence of a morning BP surge (the 'surge group'). Sleep trough surge and prewaking surge data were available at both baseline and week 14 in 548 patients, 147 of whom (azilsartan 76; candesartan 71) had a baseline morning BP surge. In surge group patients, azilsartan significantly reduced both the sleep trough surge and the prewaking surge at week 14 compared with candesartan (least squares means of the between-group differences -5.8 mmHg, P=0.0395; and -5.7 mmHg, P=0.0228, respectively). Once-daily azilsartan improved sleep trough surge and prewaking surge to a greater extent than candesartan in Japanese patients with grade I-II essential hypertension.

Method and apparatus for measuring shear modulus and viscosity of a monomolecular film

DOEpatents

Abraham, B.M.; Miyano, K.; Ketterson, J.B.

1983-10-18

Apparatus for measuring the shear modulus of a monomolecular film comprises a circular trough having inwardly sloping sides containing a liquid for supporting the monolayer on the surface thereof; a circular rotor suspended above the trough such that the lower surface of the rotor contacts the surface of the liquid, positioned such that the axis of the rotor is concentric with the axis of the trough and freely rotable about its axis; means for hydrostatically compressing the monolayer in the annular region formed between the rotor and the sides of the trough; and means for rotating the trough about its axis. Preferably, hydrostatic compression of the monolayer is achieved by removing liquid from the bottom of the trough (decreasing the surface area) while raising the trough vertically along its axis to maintain the monolayer at a constant elevation (and maintain rotor contact). In order to measure viscosity, a means for rotating the rotor about its axis is added to the apparatus.

Method and apparatus for measuring shear modulus and viscosity of a monomolecular film

DOEpatents

Abraham, Bernard M.; Miyano, Kenjiro; Ketterson, John B.

1985-01-01

Instrument for measuring the shear modulus of a monomolecular film comprises a circular trough having inwardly sloping sides containing a liquid for supporting the monolayer on the surface thereof; a circular rotor suspended above the trough such that the lower surface of the rotor contacts the surface of the liquid, positioned such that the axis of the rotor is concentric with the axis of the trough and freely rotable about its axis; apparatus for hydrostatically compressing the monolayer in the annular region formed between the rotor and the sides of the trough; and apparatus for rotating the trough about its axis. Preferably, hydrostatic compression of the monolayer is achieved by removing liquid from the bottom of the trough (decreasing the surface area) while raising the trough vertically along its axis to maintain the monolayer at a constant elevation (and maintain rotor contact). In order to measure viscosity, a apparatus for rotating the rotor about its axis is added to the apparatus.

Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation.

PubMed

Döring, Michaela; Cabanillas Stanchi, Karin Melanie; Queudeville, Manon; Feucht, Judith; Blaeschke, Franziska; Schlegel, Patrick; Feuchtinger, Tobias; Lang, Peter; Müller, Ingo; Handgretinger, Rupert; Heinz, Werner J

2017-07-01

Paediatric recipients of haematopoietic stem cell transplantation (HSCT) have a high risk for invasive fungal infections. Posaconazole oral suspension has proven to be effective in antifungal prophylaxis in adult and paediatric patients. A new posaconazole tablet formulation with absorption independent of the gastric conditions was approved by the FDA in 2013. This is the first report on the use of posaconazole tablets in paediatric patients. This single-centre study included 63 paediatric patients with haemato-oncological malignancies who received posaconazole for antifungal prophylaxis after HSCT. They were analysed for efficacy, feasibility and the safety of posaconazole. Out of 63 patients, 31 received posaconazole oral suspension and 32 received posaconazole tablets up to 200 days after transplantation. Analyses of the posaconazole trough levels were determined. No possible, probable or proven invasive fungal infection was observed in either group. Posaconazole trough levels were significantly higher in the tablet group than in the suspension group at all analysed time points. Drug-related adverse events were similarly low in both groups. Posaconazole tablets are effective in preventing invasive fungal infections in paediatric patients. As early as day 3 after starting posaconazole tablets, over 50% of the posaconazole trough levels were >500 ng/mL, while this was observed on day 14 after start with posaconazole suspension. The administration of posaconazole tablets was safe, effective and feasible as antifungal prophylaxis in paediatric patients after HSCT.

Area-under-the-curve monitoring of cyclosporine therapy: Performance of different assay methods and their target concentrations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grevel, J.; Napoli, K.L.; Gibbons, S.

1990-01-01

The measurement of areas under the concentration-time curve (AUC) was recently introduced as an alternative to trough level monitoring of cyclosporine therapy. The AUC is divided by the oral dosing interval to calculate an average concentration. All measurements are performed at clinical steady state. The initial evaluation of AUC monitoring showed advantages over trough level monitoring with concentrations of cyclosporine measured in serum by the polyclonal radioimmunoassay of Sandoz. This assay technique is no longer available and the following assays were performed in parallel during up to 173 AUC determinations in 51 consecutive renal transplant patients: polyclonal fluorescence polarization immunoassaymore » of Abbott in serum, specific and nonspecific monoclonal radioimmunoassays using {sup 3}H and {sup 125}I tracers in serum and whole blood, and high performance liquid chromatography in whole blood. Both trough levels and average concentrations at steady state measured by those different techniques were significantly correlated with the oral dose. The best correlation (r2 = 0.54) was shown by average concentrations measured in whole blood by the specific monoclonal radioimmunoassay of Sandoz ({sup 3}H tracer). This monitoring technique was also associated with the smallest absolute error between repeated observations in the same patient while the oral dose rate remained the same or was changed. Both allegedly specific monoclonal radioimmunoassays (with {sup 3}H and {sup 125}I tracer) measured significantly higher concentrations than the liquid chromatography.« less

Predicting Tropical Cyclogenesis with a Global Mesoscale Model: Hierarchical Multiscale Interactions During the Formation of Tropical Cyclone Nargis(2008)

NASA Technical Reports Server (NTRS)

Shen, B.-W.; Tao, W.-K.; Lau, W. K.; Atlas, R.

2010-01-01

Very severe cyclonic storm Nargis devastated Burma (Myanmar) in May 2008, caused tremendous damage and numerous fatalities, and became one of the 10 deadliest tropical cyclones (TCs) of all time. To increase the warning time in order to save lives and reduce economic damage, it is important to extend the lead time in the prediction of TCs like Nargis. As recent advances in high-resolution global models and supercomputing technology have shown the potential for improving TC track and intensity forecasts, the ability of a global mesoscale model to predict TC genesis in the Indian Ocean is examined in this study with the aim of improving simulations of TC climate. High-resolution global simulations with real data show that the initial formation and intensity variations of TC Nargis can be realistically predicted up to 5 days in advance. Preliminary analysis suggests that improved representations of the following environmental conditions and their hierarchical multiscale interactions were the key to achieving this lead time: (1) a westerly wind burst and equatorial trough, (2) an enhanced monsoon circulation with a zero wind shear line, (3) good upper-level outflow with anti-cyclonic wind shear between 200 and 850 hPa, and (4) low-level moisture convergence.

Chronostratigraphy of the Fish Creek-Vallecito Basin, SW Salton Trough: A High-Fidelity Record of Slip on the West Salton Detachment Fault and Subsidence in its Upper Plate

NASA Astrophysics Data System (ADS)

Dorsey, R. J.; Housen, B. A.; Janecke, S. U.; McDougall, K.; Fanning, M.; Fluette, A.; Axen, G. J.; Shirvell, C. R.

2006-12-01

The Fish Creek-Vallecito basin contains a 5.1-km thick section of sedimentary rocks in the SW Salton Trough that range in age from 8.1 to 0.9 Ma. The section preserves a record of basin subsidence related to slip on the West Salton detachment fault (WSDF), which formed the main western rift-flank structure of the Salton Trough. We obtained a well-constrained chronology from compilation of existing (Johnson et al., 1983) and new paleomagnetic data, ages of two tuffs high in the section, and thicknesses calculated from the geologic map of Winker (1987) and our work in the lower 1.3 km. The tuffs yielded SHRIMP U-Pb ages of 2.56 ± 0.09 and 2.54 ± 0.09 Ma from single zircons. Geohistory analysis, corrected for paleobathymetry and global sea- level change, yields a decompacted subsidence curve with 5 segments bounded by abrupt changes in subsidence rate: (1) 0.46 mm/yr from 8.1 to 5.5 Ma; (2) 1.8 mm/yr from 5.5 to 5.2 Ma; (3) zero subsidence or slight uplift from 5.2 to 4.6 Ma; (4) 1.9 mm/yr from 4.6 to 3.2 Ma; and (5) 0.4 mm/yr from 3.2 to 0.9 Ma. The base of the Elephant Trees Fm, dated here at 8.1 Ma, provides the earliest well dated record of extension in the SW Salton Trough. Earliest marine incursion is dated at 6.3 Ma, and the first appearance of Colorado River sand coincides closely with the Miocene-Pliocene boundary (5.33 Ma). Because the base of the marine Imperial Group does not coincide with a change in subsidence rate, we suggest that initial marine incursion resulted from a latest Miocene global sea-level highstand superposed on steady subsidence. Thus, the inflections at 8.1 and 5.5 Ma are the two most likely ages for onset of slip on the WSDF, but 4.6 Ma is also possible. Variations in subsidence rate are not predicted by models for extensional detachment faults, and may reflect episodic pulsed fault slip and/or long-wavelength folding related to dextral-wrench tectonics. Rapid subsidence in segment 4 began during progradation of the Colorado River delta into the Imperial seaway, and continued during deposition of the fluvial Diablo and Olla formations. It ended at 3.2 Ma, 0.4 m.y. prior to the end of Colorado River sand input and transition to locally-derived Hueso Fm. This abrupt change in sediment composition occurred during slip on the WSDF, and may have been driven by an increase in sediment supply related to climate change. The entire basin has been inverted and completely exhumed, suggesting a rock uplift rate of ca. 6 mm/yr during the past 0.9 m.y. Rapid uplift coincides with modern transpressional deformation and strike-slip faults that cross-cut and terminated slip on the WSDF starting at 1.1-1.3 Ma (Steely, 2006; Lutz et al., in press; Kirby et al., in press).

Seismic stratigraphic architecture of the Disko Bay trough-mouth fan system, West Greenland

NASA Astrophysics Data System (ADS)

Hofmann, Julia C.; Knutz, Paul C.

2015-04-01

Spatial and temporal changes of the Greenland Ice Sheet on the continental shelf bordering Baffin Bay remain poorly constrained. Then as now, fast-flowing ice streams and outlet glaciers have played a key role for the mass balance and stability of polar ice sheets. Despite their significance for Greenland Ice Sheet dynamics and evolution, our understanding of their long-term behaviour is limited. The central West Greenland margin is characterized by a broad continental shelf where a series of troughs extend from fjords to the shelf margin, acting as focal points for trough-mouth fan (TMF) accummulations. The sea-ward bulging morphology and abrupt shelf-break of these major depositional systems is generated by prograding depocentres that formed during glacial maxima when ice streams reached the shelf edge, delivering large amounts of subglacial sediment onto the continental slope (Ó Cofaigh et al., 2013). The aim of this study is to unravel the seismic stratigraphic architecture and depositional processes of the Disko Bay TMF, aerially the largest single sedimentary system in West Greenland, using 2D and 3D seismic reflection data, seabed bathymetry and stratigraphic information from exploration well Hellefisk-1. The south-west Disko Bay is intersected by a deep, narrow trough, Egedesminde Dyb, which extends towards the southwest and links to the shallower and broader cross-shelf Disko Trough (maximum water depths of > 1000 m and a trough length of c. 370 km). Another trough-like depression (trough length of c. 120 km) in the northern part of the TMF, indicating a previous position of the ice stream, can be distinguished on the seabed topographic map and the seismic images. The Disko Bay TMF itself extends from the shelf edge down to the abyssal plain (abyssal floor depths of 2000 m) of the southern Baffin Bay. Based on seismic stratigraphic configurations relating to reflection terminations, erosive patterns and seismic facies (Mitchum et al., 1977), the TMF succession has been divided into five seismic units, each representing different stages in the progradational accumulation of the TMF system. This poster and ongoing study will discuss how the ice-stream flow switching is linked to changes in depocentres of sedimentary sequences and further investigate the major controls, e.g. ice-sheet dynamics, ocean-climate changes, tectonic forcing and subglacial geology, that determined the evolution of the Disko Bay TMF. Essencial bibliography Mitchum, R.M. Jr., Vail, P.R., Sangree, J.B., 1977. Seismic stratigraphy and global changes of sea level, Part 6: Stratigraphic interpretation of seismic reflection patterns in depositional sequences. AAPG Memoir 26, 117-133. Ó Cofaigh, C., Andrews, J.T., Jennings, A.E., Dowdeswell, J.A., Hogan, K.A., Kilfeather, A.A., Sheldon, C., 2013. Glacimarine lithofacies, provenance and depositional processes on a West Greenland trough-mouth fan. Journal of Quaternary Science, 28(1), 13-26.

Concentrating Solar Power Projects in China | Concentrating Solar Power |

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Delingha 50MW Thermal Oil Parabolic Trough project Gansu Akesai 50MW Molten Salt Trough project Golden Tower 100MW Molten Salt project Golmud Gulang 100MW Thermal Oil Parabolic Trough project Hami 50 MW CSP Yumen 50MW Thermal Oil Trough project Shangyi 50MW DSG Tower CSP project SunCan Dunhuang 10 MW Phase I

The Relationship Between Vancomycin Trough Concentrations and AUC/MIC Ratios in Pediatric Patients: A Qualitative Systematic Review.

PubMed

Tkachuk, Stacey; Collins, Kyle; Ensom, Mary H H

2018-04-01

In adults, the area under the concentration-time curve (AUC) divided by the minimum inhibitory concentration (MIC) is associated with better clinical and bacteriological response to vancomycin in patients with methicillin-resistant Staphylococcus aureus who achieve target AUC/MIC ≥ 400. This target is often extrapolated to pediatric patients despite the lack of similar evidence. The impracticalities of calculating the AUC in practice means vancomycin trough concentrations are used to predict the AUC/MIC. This review aimed to determine the relationship between vancomycin trough concentrations and AUC/MIC in pediatric patients. We searched the MEDLINE and Embase databases, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials using the medical subject heading (MeSH) terms vancomycin and AUC and pediatric* or paediatric*. Articles were included if they were published in English and reported a relationship between vancomycin trough concentrations and AUC/MIC. Of 122 articles retrieved, 11 met the inclusion criteria. One trial reported a relationship between vancomycin trough concentrations, AUC/MIC, and clinical outcomes but was likely underpowered. Five studies found troughs 6-10 mg/l were sufficient to attain an AUC/MIC > 400 in most general hospitalized pediatric patients. One study in patients undergoing cardiothoracic surgery found a trough of 18.4 mg/l achieved an AUC/MIC > 400. Two oncology studies reported troughs ≥ 15 mg/l likely attained an AUC/MIC ≥ 400. In critical care patients: one study found a trough of 9 mg/l did not attain the AUC/MIC target; another found 7 mg/l corresponded to an AUC/MIC of 400. Potential vancomycin targets varied based on the population studied but, for general hospitalized pediatric patients, troughs of 6-10 mg/l are likely sufficient to achieve AUC/MIC ≥ 400. For MIC ≥ 2 mg/l, higher troughs are likely necessary to achieve an AUC/MIC ≥ 400. More research is needed to determine the relationships between vancomycin trough concentrations, AUC/MIC, and clinical outcomes.

Vancomycin AUC/MIC and Corresponding Troughs in a Pediatric Population

PubMed Central

Lardieri, Allison B.; Heil, Emily L.; Morgan, Jill A.

2017-01-01

OBJECTIVES Adult guidelines suggest an area under the curve/minimum inhibitory concentration (AUC/MIC) > 400 corresponds to a vancomycin trough serum concentration of 15 to 20 mg/L for methicillin-resistant Staphylococcus aureus infections, but obtaining these troughs in children are difficult. The primary objective of this study was to assess the likelihood that 15 mg/kg of vancomycin every 6 hours in a child achieves an AUC/MIC > 400. METHODS This retrospective chart review included pediatric patients >2 months to <18 years with a positive S aureus blood culture and documented MIC who received at least two doses of vancomycin with corresponding trough. Patients were divided into two groups: group 1 initially receiving ≥15 mg/kg every 6 hours, and group 2 initially receiving any other dosing ranges or intervals. AUCs were calculated four times using three pharmacokinetic methods. RESULTS A total of 36 patients with 99 vancomycin trough serum concentrations were assessed. Baseline characteristics were similar between groups. For troughs in group 1 (n = 55), the probability of achieving an AUC/MIC > 400 ranged from 16.4% to 90.9% with a median trough concentration of 11.4 mg/L, while in group 2 (n = 44) the probability of achieving AUC/MIC > 400 ranged from 15.9% to 54.5% with mean trough concentration of 9.2 mg/L. The AUC/MICs were not similar between the different pharmacokinetic methods used; however, a trapezoidal equation (Method A) yielded the highest correlation coefficient (r2 = 0.59). When dosing every 6 hours, an AUC/MIC of 400 correlated to a trough serum concentration of 11 mg/L. CONCLUSIONS The probability of achieving an AUC/MIC > 400 using only a trough serum concentration and an MIC with patients receiving 15 mg/kg every 6 hours is variable based on the method used to calculate the AUC. An AUC/MIC of 400 in children correlated to a trough concentration of 11 mg/L using a trapezoidal Method to calculate AUC. PMID:28337080

Vancomycin AUC/MIC and Corresponding Troughs in a Pediatric Population.

PubMed

Kishk, Omayma A; Lardieri, Allison B; Heil, Emily L; Morgan, Jill A

2017-01-01

Adult guidelines suggest an area under the curve/minimum inhibitory concentration (AUC/MIC) > 400 corresponds to a vancomycin trough serum concentration of 15 to 20 mg/L for methicillin-resistant Staphylococcus aureus infections, but obtaining these troughs in children are difficult. The primary objective of this study was to assess the likelihood that 15 mg/kg of vancomycin every 6 hours in a child achieves an AUC/MIC > 400. This retrospective chart review included pediatric patients >2 months to <18 years with a positive S aureus blood culture and documented MIC who received at least two doses of vancomycin with corresponding trough. Patients were divided into two groups: group 1 initially receiving ≥15 mg/kg every 6 hours, and group 2 initially receiving any other dosing ranges or intervals. AUCs were calculated four times using three pharmacokinetic methods. A total of 36 patients with 99 vancomycin trough serum concentrations were assessed. Baseline characteristics were similar between groups. For troughs in group 1 (n = 55), the probability of achieving an AUC/MIC > 400 ranged from 16.4% to 90.9% with a median trough concentration of 11.4 mg/L, while in group 2 (n = 44) the probability of achieving AUC/MIC > 400 ranged from 15.9% to 54.5% with mean trough concentration of 9.2 mg/L. The AUC/MICs were not similar between the different pharmacokinetic methods used; however, a trapezoidal equation (Method A) yielded the highest correlation coefficient (r 2 = 0.59). When dosing every 6 hours, an AUC/MIC of 400 correlated to a trough serum concentration of 11 mg/L. The probability of achieving an AUC/MIC > 400 using only a trough serum concentration and an MIC with patients receiving 15 mg/kg every 6 hours is variable based on the method used to calculate the AUC. An AUC/MIC of 400 in children correlated to a trough concentration of 11 mg/L using a trapezoidal Method to calculate AUC.

Origin and late quaternary tectonism of a western Canadian continental shelf trough

NASA Astrophysics Data System (ADS)

Moslow, Thomas F.; Luternauer, John L.; Rohr, Kristin

1991-08-01

Analyses of high resolution and multi-channel seismic profiles from the central continental shelf of western Canada ascribe a late Quaternary glacial origin to large-scale troughs. Along the margins of Moresby Trough, one of three large-scale cross-shelf bathymetric depressions in Queen Charlotte Sound, seismic profiles within Quaternary sediments show a divergence of reflectors, thickening and folding of seismic units, and concavity of reflectors suggestive of drag. Compactional subsidence, growth faulting, and compaction faulting are also observed. Fault traces commonly terminate below the seabed. Deformation of Quaternary sediments due to faulting is plastic in nature and maximum offset of reflectors is 2.5 m. The observed Quaternary deformation appears to be a product of rapid deposition, loading and subsidence of late Quaternary sediment, which is unrelated to seismic activity. In addition, Quaternary faulting was probably activated by post-glacial loading and isostatic rebound of consolidated Tertiary strata along the margins of continental shelf troughs. The presence of mass movement (slump or debris flow) deposits overlying lithified Tertiary strata along the flanks of Moresby Trough provides the only evidence of seismic activity in the study area. The lack of a mud drape over these deposits implies a late Holocene age for the timing of their emplacement. The Quaternary troughs are incised into Tertiary-aged sedimentary fill of the Queen Charlotte basin. Previous workers had interpreted seafloor escarpments paralleling the trough margins to indicate that the location of Moresby Trough was controlled by renewed or continued activity on Tertiary-aged faults. A multi-channel seismic line across Moresby Trough shows that such an escarpment on the seafloor does not correlate to faults either in the Tertiary basin fill or the underlying basement. Tertiary reflectors are continuous underneath Moresby Trough; the seafloor escarpment is an erosional feature and was not created by reactivation of Tertiary structures. Trough erosion and subsequent fill (up to 175 m thick) are entirely of Quaternary age.

Pc-5 wave power in the plasmasphere and trough: CRRES observations

NASA Astrophysics Data System (ADS)

Hartinger, M.; Moldwin, M.; Angelopoulos, V.; Takahashi, K.; Singer, H. J.; Anderson, R. R.

2009-12-01

The CRRES (Combined Release and Radiation Effects Satellite) mission provides an opportunity to study the distribution of MHD wave power in the inner magnetosphere both inside the high-density plasmasphere and in the low-density trough. We present a statistical survey of Pc-5 wave power using CRRES magnetometer and plasma wave data separated into plasmasphere and trough intervals. Using a database of plasmapause crossings, we examined differences in power spectral density between the plasmasphere and trough regions. We found significant differences between the plasmasphere and trough in the radial profiles of Pc-5 wave power. On average, wave power was higher in the trough, but the difference in power depended on magnetic local time. Our study shows that determining the plasmapause location is important for understanding and modeling the MHD wave environment in the Pc-5 frequency band.

The light ion trough.

NASA Technical Reports Server (NTRS)

Taylor, H. A., Jr.

1972-01-01

A distinct feature of the ion composition results from the OGO-2, 4 and 6 satellites is the light ion trough, wherein the mid-latitude concentrations of H+ and He+ decrease sharply with latitude. In contrast to the 'main trough' in electron density observed primarily as a nightside phenomenon, the light ion trough persists during both day and night. For daytime winter hemisphere conditions and for all seasons during night, the mid-latitude light ion concentration decrease is a pronounced feature. In the dayside summer and equinox hemispheres, the rate of light ion decrease with latitude is comparatively gradual, and the trough boundary is less well defined, particularly for quiet magnetic conditions. In response to magnetic storms, the light ion trough minimum moves equatorward, and deepens, consistent with earlier evidence of the contraction of the plasmasphere in response to storm time enhancements in magnetospheric plasma convection.

The effects of pregnancy on the pharmacokinetics of infliximab and adalimumab in inflammatory bowel disease.

PubMed

Seow, C H; Leung, Y; Vande Casteele, N; Ehteshami Afshar, E; Tanyingoh, D; Bindra, G; Stewart, M J; Beck, P L; Kaplan, G G; Ghosh, S; Panaccione, R

2017-05-01

Transplacental transfer of infliximab and adalimumab results in detectable drug levels in the cord blood and infant. To determine if pregnancy influenced the pharmacokinetics of anti-TNF agents in women with inflammatory bowel disease. Twenty-five women from the University of Calgary inflammatory bowel disease(IBD) pregnancy clinic on maintenance infliximab or adalimumab were recruited prospectively with serum bio-banking performed each trimester. Infliximab trough and adalimumab steady-state levels were the outcomes of interest and were analysed using the ANSER infliximab and adalimumab assays. Multivariate linear mixed-effects models were constructed to assess infliximab and adalimumab drug levels during pregnancy adjusting for the clinical covariates of albumin, BMI and CRP. Fifteen women (eight Crohn's disease, seven ulcerative colitis) received infliximab and 10 women with 11 pregnancies were treated with adalimumab. Median age was 29.6 years (IQR: 27.6-31.2 years). Median disease duration was 9.2 years (IQR: 3.16-15.0 years). Median trough infliximab concentrations were 8.50 μg/mL (IQR: 7.23-10.07 μg/mL), 10.31 μg/mL (IQR: 7.66-15.63 μg/mL) and 21.02 μg/mL (IQR: 16.01-26.70 μg/mL) at trimesters 1, 2 and 3 respectively. Significant changes in albumin and BMI (P < 0.05) but not CRP (P > 0.05) were documented throughout pregnancy. After adjusting for albumin, BMI and CRP, infliximab trough levels increased during pregnancy, by 4.2 μg/mL per trimester (P = 0.02), while adalimumab drug levels remained stable (P > 0.05). Infliximab levels rise during pregnancy, whereas adalimumab levels remain stable after accounting for changes in albumin, BMI and CRP. Therapeutic drug monitoring in the second trimester may be useful in guiding dosing in the third trimester. © 2017 John Wiley & Sons Ltd.

Fabrication of trough-shaped solar collectors

DOEpatents

Schertz, William W.

1978-01-01

There is provided a radiant energy concentration and collection device formed of a one-piece thin-walled plastic substrate including a plurality of nonimaging troughs with certain metallized surfaces of the substrate serving as reflective side walls for each trough. The one-piece plastic substrate is provided with a seating surface at the bottom of each trough which conforms to the shape of an energy receiver to be seated therein.

Eos Chaos Rocks

NASA Technical Reports Server (NTRS)

2006-01-01

11 January 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows light-toned, layered rock outcrops in Eos Chaos, located near the east end of the Valles Marineris trough system. The outcrops occur in the form of a distinct, circular butte (upper half of image) and a high slope (lower half of image). The rocks might be sedimentary rocks, similar to those found elsewhere exposed in the Valles Marineris system and the chaotic terrain to the east of the region.

Location near: 12.9oS, 49.5oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Southern Summer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schuett, K.J.; Pawlak, J.P.; Traina, L.

No. 13 Blast Furnace at US Steel`s Gary Works is a 35 tuyere furnace with a 36.5 ft. hearth capable of producing over 9,000 tons of hot metal per day. The current casthouse design was placed in service following the second reline in the fall of 1979. This design anticipated daily production rates averaging 7,500 tons of hot metal per day and provided for removable troughs at two of the three tapholes. At the time, the troughs were rammed with a high alumina/silicon carbide granular ramming material that provided the operators with trough campaign lives between 60,000--70,000 tons of hotmore » metal produced. As refractory technology progressed, low cement/low moisture castables were introduced to the trough systems on No. 13 Blast Furnace. The immediate success of the castables was tempered by emergence of a new unexpected problem. That problem was the thermal expansion of the castable. The paper describes the problems that resulted in the need to modify the trough design, the new design of the trough, and its improvement in iron trough campaign life and reliability.« less

Designing Better Water Troughs: Does Trough Color Influence Dairy Cows' Preference?

PubMed

Lemos Teixeira, Dayane; Hötzel, Maria José; Pinheiro Machado Filho, Luiz Carlos; Cazale, José Daniel; Enríquez-Hidalgo, Daniel

2017-01-01

Eighteen lactating dairy cows were used to elucidate their preference for green, grey, or red troughs. The herd was managed under a rotational grazing system with ad-libitum access to water until 11:30 h. For 9 days, all cows were tested individually following the afternoon milking. Cows drank similar quantities, spent a similar amount of time drinking, and took a similar number of sips from the 3 trough colors (p > .05). In 75% of the tests, cows drank more than 95% of the test period from the same trough. Within this time, the percentage of choices did not differ among colors (33.3% green, 39.0% grey, and 27.7% red). When they chose the red trough, cows spent less time drinking (p ≤ .05) and tended to take fewer sips (p = .07), which could suggest a partial aversion to this color. Suboptimal water trough design may have long-term negative effects on both the production and welfare of dairy cattle; however, the results suggest that color does not play a major role in the drinking behavior of dairy cows.

Dense Ocean Floor Network for Earthquakes and Tsunamis; DONET/ DONET2, Part2 -Development and data application for the mega thrust earthquakes around the Nankai trough-

NASA Astrophysics Data System (ADS)

Kaneda, Y.; Kawaguchi, K.; Araki, E.; Matsumoto, H.; Nakamura, T.; Nakano, M.; Kamiya, S.; Ariyoshi, K.; Baba, T.; Ohori, M.; Hori, T.; Takahashi, N.; Kaneko, S.; Donet Research; Development Group

2010-12-01

Yoshiyuki Kaneda Katsuyoshi Kawaguchi*, Eiichiro Araki*, Shou Kaneko*, Hiroyuki Matsumoto*, Takeshi Nakamura*, Masaru Nakano*, Shinichirou Kamiya*, Keisuke Ariyoshi*, Toshitaka Baba*, Michihiro Ohori*, Narumi Takakahashi*, and Takane Hori** * Earthquake and Tsunami Research Project for Disaster Prevention, Leading Project , Japan Agency for Marine-Earth Science and Technology (JAMSTEC) **Institute for Research on Earth Evolution, Japan Agency for Marine-Earth Science and Technology (JAMSTEC) DONET (Dense Ocean Floor Network for Earthquakes and Tsunamis) is the real time monitoring system of the Tonankai seismogenic zones around the Nankai trough southwestern Japan. We were starting to develop DONET to perform real time monitoring of crustal activities over there and the advanced early warning system. DONET will provide important and useful data to understand the Nankai trough maga thrust earthquake seismogenic zones and to improve the accuracy of the earthquake recurrence cycle simulation. Details of DONET concept are as follows. 1) Redundancy, Extendable function and advanced maintenance system using the looped cable system, junction boxes and the ROV/AUV. DONET has 20 observatories and incorporated in a double land stations concept. Also, we are developed ROV for the 10km cable extensions and heavy weight operations. 2) Multi kinds of sensors to observe broad band phenomena such as long period tremors, very low frequency earthquakes and strong motions of mega thrust earthquakes over M8: Therefore, sensors such as a broadband seismometer, an accelerometer, a hydrophone, a precise pressure gauge, a differential pressure gauge and a thermometer are equipped with each observatory in DONET. 3) For speedy detections, evaluations and notifications of earthquakes and tsunamis: DONET system will be deployed around the Tonankai seismogenic zone. 4) Provide data of ocean floor crustal deformations derived from pressure sensors: Simultaneously, the development of data assimilation method using DONET data is very important to improve the recurrence cycle simulation model. 5) Understanding of the interaction between the crust and upper mantle around the Nankai trough subduction zone. We will deploy DONET not only in the Tonankai seismogenic zone but also DONET2 with high voltages in the Nankai seismogenic zone western the Nankai trough: The total system will be deployed to understand the seismic linkage between the Tonankai and Nankai earthquakes: Using DONET and DONET2 data, we will be able to observe the crustal activities and before and after slips at the Tonankai earthquake and Nankai earthquake. And we will improve the recurrence cycle simulation model by the advanced data assimilation method. Actually, we constructed one observatory in DONET and observed some earthquakes and tsunamis. We will introduce details of DONET/DONET2 and some observed data.

New sidescan sonar and gravity evidence that the Nova-Canton Trough is a fracture zone

NASA Astrophysics Data System (ADS)

Joseph, Devorah; Taylor, Brian; Shor, Alexander N.

1992-05-01

A 1990 sidescan sonar survey in the eastern region of the Nova-Canton Trough mapped 138°-striking abyssal-hill fabric trending into 70°-striking trough structures. The location and angle of intersection of the abyssal hills with the eastern Nova-Canton Trough effectively disprove a spreading-center origin of this feature. Free-air gravity anomalies derived from satellite altimetry data show continuity, across the Line Islands, of the Nova-Canton Trough with the Clipperton Fracture Zone. The Canton-Clipperton trend is copolar, about a pole at 30°S, 152°W, with other coeval Pacific-Farallon fracture-zone segments, from the Pau to Marquesas fracture zones. This copolarity leads us to postulate a Pacific-Farallon spreading pattern for the magnetic quiet zone region north and east of the Manihiki Plateau, with the Nova-Canton Trough originating as a transform fault in this system.

Storminess and cold air outbreaks in NE America during AD 1790-1820

NASA Astrophysics Data System (ADS)

van der Schrier, G.; Jones, P. D.

2008-01-01

Two hypotheses have been put forward to explain the anomalously deep trough in winter sea-level pressure in the northwestern Atlantic sector during the AD 1790-1820 period. One relates it to an increase in cyclolysis in this area, the other to a change in the general planetary circulation. In an attempt to distinguish between these hypotheses, storminess and cold air outbreaks (CAO) in the northeastern USA during 1790-1820 are studied, based on a record of daily pressure and temperature observations at Salem (Massachusetts, USA). Frequency changes of CAO act as proxy for planetary circulation changes. It is found that CAO in the early period were both more persistent and severe than those in the modern control period. No evidence of elevated levels of storminess in the 1790-1820 period was found. This suggests that the anomalously deep trough can be attributed mainly to a change in the planetary circulation.

Factors favorable to frequent extreme precipitation in the upper Yangtze River Valley

NASA Astrophysics Data System (ADS)

Tian, Baoqiang; Fan, Ke

2013-08-01

Extreme precipitation events in the upper Yangtze River Valley (YRV) have recently become an increasingly important focus in China because they often cause droughts and floods. Unfortunately, little is known about the climate processes responsible for these events. This paper investigates factors favorable to frequent extreme precipitation events in the upper YRV. Our results reveal that a weakened South China Sea summer monsoon trough, intensified Eurasian-Pacific blocking highs, an intensified South Asian High, a southward subtropical westerly jet and an intensified Western North Pacific Subtropical High (WNPSH) increase atmospheric instability and enhance the convergence of moisture over the upper YRV, which result in more extreme precipitation events. The snow depth over the eastern Tibetan Plateau (TP) in winter and sea surface temperature anomalies (SSTAs) over three key regions in summer are important external forcing factors in the atmospheric circulation anomalies. Deep snow on the Tibetan Plateau in winter can weaken the subsequent East Asian summer monsoon circulation above by increasing the soil moisture content in summer and weakening the land-sea thermal contrast over East Asia. The positive SSTA in the western North Pacific may affect southwestward extension of the WNPSH and the blocking high over northeastern Asia by arousing the East Asian-Pacific pattern. The positive SSTA in the North Atlantic can affect extreme precipitation event frequency in the upper YRV via a wave train pattern along the westerly jet between the North Atlantic and East Asia. A tripolar pattern from west to east over the Indian Ocean can strengthen moisture transport by enhancing Somali cross-equatorial flow.

The OAE1a in Cuchía (Early Aptian, Spain): C and O geochemistry and global correlation

NASA Astrophysics Data System (ADS)

García-Mondéjar, Joaquín; Fernández-Mendiola, Pedro A.; Owen, Hugh G.

2015-12-01

C-isotopes, TOC and O geochemical data from the lower Aptian Cuchía section in the western Basque-Cantabrian basin (BCB) allow an accurate delimitation of the OAE1a-equivalent and its geochemical Menegattís segments, a detailed δ13Ccarb correlation with regional and interregional sections, and a high-resolution construction of TOC and bulk-rock δ18Ocarb curves and their interpretation. The δ13Ccarb values range from -2‰ and +4‰ (VPDB). They agree with previous data from the eastern BCB sections (Aralar) confirming the ammonite age of the OAE1a in the Basque-Cantabrian basin: Deshayesites forbesi, Deshayesites deshayesi, and Deshayesites deshayesi-Dufrenoyia furcata transition Zones. Interregional δ13Ccarb correlation with pelagic (Cismon, Italy, and Mid-Pacific Mountains, DSDP Site 463) and neritic (Roquefort-La Bédoule, France) core sections, reveals a common profile of a wide negative excursion characteristic of the OAE1a. It consists of a double trough separated by a flat relative maximum, with two negative spikes in the upper trough of neritic sections. TOC absolute values range from 0.12% to 1.37%. Segments of the TOC curve with persistent low values closely correspond with descending segments of the δ13Ccarb curve, and are attributed to lesser organic productivity in the BCB. Detailed bulk-rock δ18Ocarb data (-5.71‰ to -1.05 ‰ PDB) and variation curve show two main positive O-isotope shifts and three minor positive inflections, within a general negative trend characteristic of the OAE1a. The two major positive shifts correspond to both shallowing upwards sequences and the lowermost can be related to a eustatic sea level fall. Independent interregional correlation of the O-isotope shifts with C-isotopes supports their interpretation as punctuating colder events within a general warming trend.

Revisiting the 1993 historical extreme precipitation and damaging flood event in Central Nepal

NASA Astrophysics Data System (ADS)

Marahatta, S.; Adhikari, L.; Pokharel, B.

2017-12-01

Nepal is ranked the fourth most climate-vulnerable country in the world and it is prone to different weather-related hazards including droughts, floods, and landslides [Wang et al., 2013; Gillies et al., 2013]. Although extremely vulnerable to extreme weather events, there are no extreme weather warning system established to inform public in Nepal. Nepal has witnessed frequent drought and flood events, however, the extreme precipitation that occurred on 19-20 July 1993 created a devastating flood and landslide making it the worst weather disaster in the history of Nepal. During the second week of July, Nepal and northern India experienced abnormal dry condition due to the shifting of the monsoon trough to central India. The dry weather changed to wet when monsoon trough moved northward towards foothills of the Himalayas. Around the same period, a low pressure center was located over the south-central Nepal. The surface low was supported by the mid-, upper-level shortwave and cyclonic vorticity. A meso-scale convective system created record breaking one day rainfall (540 mm) in the region. The torrential rain impacted the major hydropower reservoir, Bagmati barrage in Karmaiya and triggered many landslides and flash floods. The region had the largest hydropower (Kulekhani hydropower, 92 MW) of the country at that time and the storm event deposited extremely large amount of sediments that reduced one-fourth (4.8 million m3) of reservoir dead storage (12 million m3). The 1-in-1000 years flood damaged the newly constructed barrage and took more than 700 lives. Major highways were damaged cutting off supply of daily needed goods, including food and gas, in the capital city, Kathmandu, for more than a month. In this presentation, the meteorological conditions of the extreme event will be diagnosed and the impact of the sedimentation due to the flood on Kulekhani reservoir and hydropower generation will be discussed.

Bedrock morphology reveals drainage network in northeast Baffin Bay

NASA Astrophysics Data System (ADS)

Slabon, Patricia; Dorschel, Boris; Jokat, Wilfried; Freire, Francis

2018-02-01

A subglacial drainage network underneath the paleo-ice sheet off West Greenland is revealed by a new compilation of high-resolution bathymetry data from Melville Bay, northeast Baffin Bay. This drainage network is an indicator for ice streaming and subglacial meltwater flow toward the outer shelf. Repeated ice sheet advances and retreats across the crystalline basement together with subglacial meltwater drainage had their impact in eroding overdeepened troughs along ice stream pathways. These overdeepenings indicate the location of a former ice sheet margin. The troughs inherit characteristics of glacial and subglacial meltwater erosion. Most of the troughs follow tectonic weakness zones such as faults and fractures in the crystalline bedrock. Many of these tectonic features correspond with the orientations of major fault axes in the Baffin Bay region. The troughs extend from the present (sub) glacial fjord systems at the Greenland coast and parallel modern outlet-glacier pathways. The fast flowing paleo-ice streams were likely accelerated from the meltwater flow as indicated by glacial landforms within and along the troughs. The ice streams flowed along narrow tributary troughs and merged to form large paleo-ice streams bedded in the major cross-shelf troughs of Melville Bay. Apart from the troughs, a rough seabed topography characterises the bedrock, and we see a sharp geomorphic transition where ice flowed onto sedimentary rock and deposits.

Seasonal variation and solar activity dependence of the quiet-time ionospheric trough

NASA Astrophysics Data System (ADS)

Ishida, T.; Ogawa, Y.; Kadokura, A.; Hiraki, Y.; Häggström, I.

2014-08-01

We have conducted a statistical analysis of the ionospheric F region trough, focusing on its seasonal variation and solar activity dependence under geomagnetically quiet and moderate conditions, using plasma parameter data obtained via Common Program 3 observations performed by the European Incoherent Scatter (EISCAT) radar between 1982 and 2011. We have confirmed that there is a major difference in frictional heating between the high- and low-latitude sides of the EISCAT field of view (FOV) at ~73°0'N-60°5'N (geomagnetic latitude) at an altitude of 325 km, which is associated with trough formation. Our statistical results show that the high-latitude and midlatitude troughs occur on the high- and low-latitude sides of the FOV, respectively. Seasonal variations indicate that dissociative recombination accompanied by frictional heating is a main cause of trough formation in sunlit regions. During summer, therefore, the occurrence rate is maintained at 80-90% in the postmidnight high-latitude region owing to frictional heating by eastward return flow. Solar activity dependence on trough formation indicates that field-aligned currents modulate the occurrence rate of the trough during the winter and equinox seasons. In addition, the trough becomes deeper via dissociative recombination caused by an increased ion temperature with F10.7, at least in the equinox and summer seasons but not in winter.

The prevalence of Escherichia coli O157:H7 fecal shedding in feedlot pens is affected by the water-to-cattle ratio: A randomized controlled trial.

PubMed

Beauvais, Wendy; Gart, Elena V; Bean, Melissa; Blanco, Anthony; Wilsey, Jennifer; McWhinney, Kallie; Bryan, Laura; Krath, Mary; Yang, Ching-Yuan; Manriquez Alvarez, Diego; Paudyal, Sushil; Bryan, Kelsey; Stewart, Samantha; Cook, Peter W; Lahodny, Glenn; Baumgarten, Karina; Gautam, Raju; Nightingale, Kendra; Lawhon, Sara D; Pinedo, Pablo; Ivanek, Renata

2018-01-01

Escherichia coli O157:H7 fecal shedding in feedlot cattle is common and is a public health concern due to the risk of foodborne transmission that can result in severe, or even fatal, disease in people. Despite a large body of research, few practical and cost-effective farm-level interventions have been identified. In this study, a randomized controlled trial was conducted to assess the effect of reducing the level of water in automatically refilling water-troughs on fecal shedding of E. coli O157:H7 in feedlot cattle. Pens in a feedlot in the Texas Panhandle were randomly allocated as control (total number: 17) or intervention (total number: 18) pens. Fecal samples (2,759 in total) were collected both at baseline and three weeks after the intervention, and tested for the presence of E. coli O157:H7 using immunomagnetic bead separation and selective culture. There was a strong statistical association between sampling date and the likelihood of a fecal sample testing positive for E. coli O157:H7. Pen was also a strong predictor of fecal prevalence. Despite accounting for this high level of clustering, a statistically significant association between reduced water levels in the trough and increased prevalence of E. coli O157:H7 in the feces was observed (Odds Ratio = 1.6; 95% Confidence Interval: 1.2-2.0; Likelihood Ratio Test: p = 0.02). This is the first time that such an association has been reported, and suggests that increasing water-trough levels may be effective in reducing shedding of E. coli O157:H7 in cattle feces, although further work would be needed to test this hypothesis. Controlling E. coli O157:H7 fecal shedding at the pre-harvest level may lead to a reduced burden of human foodborne illness attributed to this pathogen in beef.

The prevalence of Escherichia coli O157:H7 fecal shedding in feedlot pens is affected by the water-to-cattle ratio: A randomized controlled trial

PubMed Central

Gart, Elena V.; Bean, Melissa; Blanco, Anthony; Wilsey, Jennifer; McWhinney, Kallie; Bryan, Laura; Krath, Mary; Yang, Ching-Yuan; Manriquez Alvarez, Diego; Paudyal, Sushil; Bryan, Kelsey; Stewart, Samantha; Cook, Peter W.; Lahodny, Glenn; Baumgarten, Karina; Gautam, Raju; Nightingale, Kendra; Lawhon, Sara D.; Pinedo, Pablo; Ivanek, Renata

2018-01-01

Escherichia coli O157:H7 fecal shedding in feedlot cattle is common and is a public health concern due to the risk of foodborne transmission that can result in severe, or even fatal, disease in people. Despite a large body of research, few practical and cost-effective farm-level interventions have been identified. In this study, a randomized controlled trial was conducted to assess the effect of reducing the level of water in automatically refilling water-troughs on fecal shedding of E. coli O157:H7 in feedlot cattle. Pens in a feedlot in the Texas Panhandle were randomly allocated as control (total number: 17) or intervention (total number: 18) pens. Fecal samples (2,759 in total) were collected both at baseline and three weeks after the intervention, and tested for the presence of E. coli O157:H7 using immunomagnetic bead separation and selective culture. There was a strong statistical association between sampling date and the likelihood of a fecal sample testing positive for E. coli O157:H7. Pen was also a strong predictor of fecal prevalence. Despite accounting for this high level of clustering, a statistically significant association between reduced water levels in the trough and increased prevalence of E. coli O157:H7 in the feces was observed (Odds Ratio = 1.6; 95% Confidence Interval: 1.2–2.0; Likelihood Ratio Test: p = 0.02). This is the first time that such an association has been reported, and suggests that increasing water-trough levels may be effective in reducing shedding of E. coli O157:H7 in cattle feces, although further work would be needed to test this hypothesis. Controlling E. coli O157:H7 fecal shedding at the pre-harvest level may lead to a reduced burden of human foodborne illness attributed to this pathogen in beef. PMID:29414986

Increased water contamination and grow-out Pekin duck mortality when raised with water troughs compared to pin-metered water lines using a United States management system

PubMed Central

Schenk, A.; Porter, A. L.; Alenciks, E.; Frazier, K.; Best, A. A.; Fraley, S. M.; Fraley, G. S.

2016-01-01

Controversy has developed as to whether or not pin-metered water lines or water troughs are more appropriate for Pekin ducks. We hypothesized that water troughs would show improved duck body conditions and environmental quality compared to pin-metered water lines. To test this hypothesis, we housed ducks in 2 barns, one with water lines and one with water troughs. Water troughs were constructed to meet RSPCA guidelines for number and density of ducks and with recently described verandas. Ducks were divided into 4 pens per barn (n = 1,000 ducks/pen). The study was then repeated (n = 8 pens per water source) in a cross-over design so the barns each contained the opposite water source to the first experiment. We scored the ducks’ body condition using an established scoring rubric and analyzed using SAS Proc GLM-Mix as binomial data. Ducks housed with water troughs showed higher (thus worse condition; P < 0.001) scores for eyes, nostrils, feather quality, feather cleanliness, and foot pads. We also compared water condition, water quality, and duck mortality using a Student t test for both water sources each week. We found that the water troughs showed higher iron (P < 0.001), nitrites (P < 0.001), pH (P < 0.01), and bacterial growth (P < 0.001). The bacterial growth was shown to have higher (P < 0.001) E. coli, coliforms, and Staphylococcus in the water troughs. Water lines typically showed no bacterial growth in culture-based assays. Ducks housed with water troughs used greater (P = 0.001) volumes of water compared to ducks housed with water lines. Ducks with water troughs also showed a greater percent (P = 0.008) mortality at all ages compared to ducks with water lines. These data suggest that water troughs may not be beneficial for duck welfare and could adversely impact both environment and duck or human health. PMID:26769272

Increased water contamination and grow-out Pekin duck mortality when raised with water troughs compared to pin-metered water lines using a United States management system.

PubMed

Schenk, A; Porter, A L; Alenciks, E; Frazier, K; Best, A A; Fraley, S M; Fraley, G S

2016-04-01

Controversy has developed as to whether or not pin-metered water lines or water troughs are more appropriate for Pekin ducks. We hypothesized that water troughs would show improved duck body conditions and environmental quality compared to pin-metered water lines. To test this hypothesis, we housed ducks in 2 barns, one with water lines and one with water troughs. Water troughs were constructed to meet RSPCA guidelines for number and density of ducks and with recently described verandas. Ducks were divided into 4 pens per barn (n=1,000 ducks/pen). The study was then repeated (n=8 pens per water source) in a cross-over design so the barns each contained the opposite water source to the first experiment. We scored the ducks' body condition using an established scoring rubric and analyzed using SAS Proc GLM-Mix as binomial data. Ducks housed with water troughs showed higher (thus worse condition; P<0.001) scores for eyes, nostrils, feather quality, feather cleanliness, and foot pads. We also compared water condition, water quality, and duck mortality using a Student t test for both water sources each week. We found that the water troughs showed higher iron (P<0.001), nitrites (P<0.001), pH (P<0.01), and bacterial growth (P<0.001). The bacterial growth was shown to have higher (P<0.001)E. coli, coliforms, and Staphylococcusin the water troughs. Water lines typically showed no bacterial growth in culture-based assays. Ducks housed with water troughs used greater (P=0.001) volumes of water compared to ducks housed with water lines. Ducks with water troughs also showed a greater percent (P=0.008) mortality at all ages compared to ducks with water lines. These data suggest that water troughs may not be beneficial for duck welfare and could adversely impact both environment and duck or human health. © The Author 2016. Published by Oxford University Press on behalf of Poultry Science Association.

A pharmacokinetic and pharmacodynamic comparison of immediate-release metoprolol and extended-release metoprolol CR/XL in patients with suspected acute myocardial infarction: a randomized, open-label study.

PubMed

Karlson, Björn W; Dellborg, Mikael; Gullestad, Lars; Aberg, Jan; Sugg, Jennifer; Herlitz, Johan

2014-01-01

Previous metoprolol studies in myocardial infarction patients were performed with immediate-release (IR) metoprolol. This study aims to evaluate if extended-release metoprolol CR/XL once daily gives a similar β-blockade over 24 h compared to multiple dosing of metoprolol IR. After 2 days of routine metoprolol treatment, 27 patients with suspected acute myocardial infarction were randomized to open-label treatment with metoprolol IR (50 mg four times daily or 100 mg twice daily) or metoprolol CR/XL 200 mg once daily for 3 days. Metoprolol CR/XL 200 mg once daily gave more pronounced suppression of peak heart rate, with lower peak and less variation in peak to trough plasma levels. There were no differences in AUC between the CR/XL and IR formulations, although the trough plasma metoprolol levels were comparable for metoprolol CR/XL 200 mg once daily and metoprolol IR 50 mg four times daily, but lower for metoprolol IR 100 mg twice daily. Both treatments were well tolerated. Metoprolol CR/XL 200 mg once daily showed lower peak and less variation in peak to trough plasma levels compared to multiple dosing of metoprolol IR with the same AUC. This was accompanied by a more uniform β-blockade over time, which was reflected by heart rate, and a more pronounced suppression of peak heart rate with similar tolerability. This suggests metoprolol CR/XL may be used as an alternative to metoprolol IR in patients with myocardial infarction. © 2013 S. Karger AG, Basel.

Facies architecture and sequence-stratigraphic features of the Tumbiana Formation: A depositional setting of late Archaean stromatolites in the Pilbara Craton, northwestern Australia

NASA Astrophysics Data System (ADS)

Sakurai, R.; Ueno, Y.; Kitajima, K.; Ito, M.; Maruyama, S.

2001-12-01

The Tumbiana Formation (ca. 2700 Ma) is a succession developed in response to late Archaean crustal extension in the Pilbara Craton, northwestern Australia. The formation is characterized by intercalations of stromatolite carbonates and provides a perspective of evolution of photosynthetic organisms that are interpreted to have been responsible for oxygenation of atmosphere. Here we investigated a depositional setting of the stromatolite limestone for better understanding of an environment that may have controlled early development of oxygenic photosynthesis. We studied lithofacies and sequence-stratigraphic features of the Tumbiana Formation in the Redmont area based upon three-dimensional analyses of onshore outcrops. The Tumbiana Formation, as much as 170 m thick, unconformably overlies the early Archaean basement rocks and is unconformably overlain by the Maddina Formation that consists of mafic tuffaceous sediments and basalt. The lower part of the Tumbiana Formation is characterized by planar- and trough-cross stratified conglomerates that are interpreted to be an alluvial-fan deposit shed from the northern hinterlands and developed mainly in local depressions of the basement rocks during an early transgressive stage. The base of the middle part is defined by a transgressive erosional surface overlain by conglomerates and/or breccia that pass upward to mafic tuffaceous mudstones and sandstones intercalated with accretionary lapilli, breccia, and basalt. Mudstones are commonly laminated and sandstones contain current- and wave ripple-lamination, parallel lamination, hummocky cross-stratification, and trough cross-stratification. In general, the middle part exhibits an overall fining- and coarsening-upward pattern and is interpreted to indicate transgressive and regressive shelf-to-coastal lithofacies successions. In particular, the uppermost horizon of the middle part is characterized by sandstone beds with herringbone structures and desiccation cracks and is interpreted to indicate an intertidal environment developed during a late highstand stage. The middle part, in general, thickens to the northern proximal area and eventually flattens out topographic irregularity of the basement rocks. The upper part is characterized by stromatolite carbonates, associated with minor wave- and current-rippled sandstones and desiccation cracks, and does not exhibit distinct lateral variation in thickness. The base of the upper part is also characterized by a transgressive lag deposit and the ensuing transgression over intertidal deposits of the middle part is interpreted to have developed an accommodation space for the vertical stacking of stromatolites with different external shapes from columnar and small domal types to a large domal type that may have responded to the increase in paleowater depth possibly from intertidal to subtidal environments. In conclusion, stromatolites in the upper Tumbiana Formation in the Redmont area are interpreted to have developed in coastal and shallow marine environments in response to a rise in relative sea level rather than in ephemeral saline lakes as proposed by previous studies from different locations.

Structural features related to the volcanic gases in Southern Okinawa Trough

NASA Astrophysics Data System (ADS)

Wang, H. F.; Hsu, S. K.; Tsia, C. H.; Chen, S. C.; Wu, M. F.

2016-12-01

The Okinawa Trough is a rifted back-arc basin, heavily sedimented and formed in an intracontinental rift zone behind the Ryukyu trench-arc system. The Southern Okinawa Trough (SOT) east of Taiwan is the place where post-collisional extension happened. The collision moved southwestward and the Ryukyu trench-arc extension westward, Arc volcanism is dominant in the Northern Ryukyu volcanic arc and back-arc volcanism in the Southern Okinawa Trough. Marine geophysical data including side-scan sonar (SSS), sub-bottom profiler (SBP) and echo sounder system (EK60) data are used in this study. Active fluid activities out of seafloor are obvious from various images observed on these data, such as gas plumes. These hydrothermal vents have been located at a water depth of 1400 m. Our preliminary results show that gas seepage structures appear in the location where is a week zone, such as a normal fault in the slope. The hydrothermal activity within the Okinawa Trough is associated with volcanism located in rift zones in the Southern Okinawa Trough. However, the origin of the submarine hydrothermal fluids within the Okinawa Trough is diverse with contributions from volcanic, sedimentary and magmatic sources, needed further investigations.

High H2O/Ce of K-rich MORB from Lena Trough and Gakkel Ridge, Arctic Ocean

NASA Astrophysics Data System (ADS)

Snow, J. E.; Feig, S. T.

2014-12-01

Lena Trough in the Arctic ocean is the oblique spreading continuation of Gakkel Ridge through the Fram Strait (eg Snow et al. 2011). Extreme trace element and isotopic compositions seen in Lena Trough basalt appear to be the enriched end member dominating the geochemistry of the Western Volcanic Zone of the Western Gakkel Ridge as traced by Pb isotopes, K2O/TiO2, Ba/Nb and other isotopic, major and trace element indicators of mixing (Nauret et al., 2011). This is in contrast to neighboring Gakkel Ridge which has been spreading for 50-60 million years. Basalts from Lena Trough also show a pure MORB noble gas signature (Nauret et al., 2010) and peridotites show no evidence of ancient components in their Os isotopes (Lassiter, et al., in press). The major and trace element compositions of the basalts, however are very distinct from MORB, being far more potassic than all but a single locality on the SW Indian Ridge. We determined H2O and trace element composiitions of a suite of 17 basalt glasses from the Central Lena Trough (CLT) and the Gakkel Western Volcanic Zone, including many of those previously analyzed by Nauret et al. (2012). The Western Gakkel glasses have high H2O/Ce for MORB (>300) suggesting a water rich source consistent with the idea that the northernmost Atlantic mantle is enriched in water (Michael et al., 1995). They are within the range of Eastern Gakkel host glasses determined by Wanless et al, 2013. The Lena Trough (CLT) glasses are very rich in water for MORB (>1% H2O) and are among the highest H2O/Ce (>400) ever measured in MORB aside from melt inclusions in olivine. Mantle melting dynamics and melt evolution cannot account for the H2O/Ce variations in MORB, as these elements have similar behavior during melting and crustal evolution. Interestingly, the H2O/K2O ratios in the basalts are only around 1. This is because the K2O levels in the CLT glasses are very high as well relative to REE. The absolutely linear relationship between H2O and K2O/TiO2 in Lena and Gakkel basalts shows that water systematics in these rocks are completely governed by source composition, with little or no modification by mantle melting dynamics or crystal fractionation. The geochemical influence of the WVZ enriched mantle source declines with distance from Lena Trough along Gakkel Ridge.

Dynamical analysis of extreme precipitation in the US northeast based on large-scale meteorological patterns

NASA Astrophysics Data System (ADS)

Agel, Laurie; Barlow, Mathew; Colby, Frank; Binder, Hanin; Catto, Jennifer L.; Hoell, Andrew; Cohen, Judah

2018-05-01

Previous work has identified six large-scale meteorological patterns (LSMPs) of dynamic tropopause height associated with extreme precipitation over the Northeast US, with extreme precipitation defined as the top 1% of daily station precipitation. Here, we examine the three-dimensional structure of the tropopause LSMPs in terms of circulation and factors relevant to precipitation, including moisture, stability, and synoptic mechanisms associated with lifting. Within each pattern, the link between the different factors and extreme precipitation is further investigated by comparing the relative strength of the factors between days with and without the occurrence of extreme precipitation. The six tropopause LSMPs include two ridge patterns, two eastern US troughs, and two troughs centered over the Ohio Valley, with a strong seasonality associated with each pattern. Extreme precipitation in the ridge patterns is associated with both convective mechanisms (instability combined with moisture transport from the Great Lakes and Western Atlantic) and synoptic forcing related to Great Lakes storm tracks and embedded shortwaves. Extreme precipitation associated with eastern US troughs involves intense southerly moisture transport and strong quasi-geostrophic forcing of vertical velocity. Ohio Valley troughs are associated with warm fronts and intense warm conveyor belts that deliver large amounts of moisture ahead of storms, but little direct quasi-geostrophic forcing. Factors that show the largest difference between days with and without extreme precipitation include integrated moisture transport, low-level moisture convergence, warm conveyor belts, and quasi-geostrophic forcing, with the relative importance varying between patterns.

Parabolic Trough Collector Cost Update for the System Advisor Model (SAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kurup, Parthiv; Turchi, Craig S.

2015-11-01

This report updates the baseline cost for parabolic trough solar fields in the United States within NREL's System Advisor Model (SAM). SAM, available at no cost at https://sam.nrel.gov/, is a performance and financial model designed to facilitate decision making for people involved in the renewable energy industry. SAM is the primary tool used by NREL and the U.S. Department of Energy (DOE) for estimating the performance and cost of concentrating solar power (CSP) technologies and projects. The study performed a bottom-up build and cost estimate for two state-of-the-art parabolic trough designs -- the SkyTrough and the Ultimate Trough. The SkyTroughmore » analysis estimated the potential installed cost for a solar field of 1500 SCAs as $170/m 2 +/- $6/m 2. The investigation found that SkyTrough installed costs were sensitive to factors such as raw aluminum alloy cost and production volume. For example, in the case of the SkyTrough, the installed cost would rise to nearly $210/m 2 if the aluminum alloy cost was $1.70/lb instead of $1.03/lb. Accordingly, one must be aware of fluctuations in the relevant commodities markets to track system cost over time. The estimated installed cost for the Ultimate Trough was only slightly higher at $178/m 2, which includes an assembly facility of $11.6 million amortized over the required production volume. Considering the size and overall cost of a 700 SCA Ultimate Trough solar field, two parallel production lines in a fully covered assembly facility, each with the specific torque box, module and mirror jigs, would be justified for a full CSP plant.« less

Thermal maturity and petroleum kitchen areas of Liassic Black Shales (Lower Jurassic) in the central Upper Rhine Graben, Germany

NASA Astrophysics Data System (ADS)

Böcker, Johannes; Littke, Ralf

2016-03-01

In the central Upper Rhine Graben (URG), several major oil fields have been sourced by Liassic Black Shales. In particular, the Posidonia Shale (Lias ɛ, Lower Toarcian) acts as excellent and most prominent source rock in the central URG. This study is the first comprehensive synthesis of Liassic maturity data in the URG area and SW Germany. The thermal maturity of the Liassic Black Shales has been analysed by vitrinite reflectance (VRr) measurements, which have been verified with T max and spore coloration index (SCI) data. In outcrops and shallow wells (<600 m), the Liassic Black Shales reached maturities equivalent to the very early or early oil window (ca. 0.50-0.60 % VRr). This maturity is found in Liassic outcrops and shallow wells in the entire URG area and surrounding Swabian Jura Mountains. Maximum temperatures of the Posidonia Shale before graben formation are in the order of 80-90 °C. These values were likely reached during Late Cretaceous times due to significant Upper Jurassic and minor Cretaceous deposition and influenced by higher heat flows of the beginning rift event at about 70 Ma. In this regard, the consistent regional maturity data (VRr, T max, SCI) of 0.5-0.6 % VRr for the Posidonia Shale close to surface suggest a major burial-controlled maturation before graben formation. These consistent maturity data for Liassic outcrops and shallow wells imply no significant oil generation and expulsion from the Posidonia Shale before formation of the URG. A detailed VRr map has been created using VRr values of 31 wells and outcrops with a structure map of the Posidonia Shale as reference map for a depth-dependent gridding operation. Highest maturity levels occur in the area of the Rastatt Trough (ca. 1.5 % VRr) and along the graben axis with partly very high VRr gradients (e.g. well Scheibenhardt 2). In these deep graben areas, the maximum temperatures which were reached during upper Oligocene to Miocene times greatly exceed those during the Cretaceous.

Self-organized criticality in sandpiles - Nature of the critical phenomenon. [dynamic models in phase transition

NASA Technical Reports Server (NTRS)

Carlson, J. M.; Chayes, J. T.; Swindle, G. H.; Grannan, E. R.

1990-01-01

The scaling behavior of sandpile models is investigated analytically. First, it is shown that sandpile models contain a set of domain walls, referred to as troughs, which bound regions that can experience avalanches. It is further shown that the dynamics of the troughs is governed by a simple set of rules involving birth, death, and coalescence events. A simple trough model is then introduced, and it is proved that the model has a phase transition with the density of the troughs as an order parameter and that, in the thermodynamic limit, the trough density goes to zero at the transition point. Finally, it is shown that the observed scaling behavior is a consequence of finite-size effects.

Preliminary Magnetostratigraphic Study of the Split Mountain and Lower Imperial Groups, Split Mountain Gorge, Western Salton Trough, CA

NASA Astrophysics Data System (ADS)

Fluette, A. L.; Housen, B. A.; Dorsey, R. J.

2004-12-01

We present preliminary results of a magnetostratigraphic study of Miocene-Pliocene sedimentary rocks of the Split Mt. and lower Imperial Groups exposed in Split Mt. Gorge and eastern Fish Creek-Vallecito basin, western Salton Trough. Precise age control for the base of this thick section is needed to improve our understanding of the early history of extension-related subsidence in this region. The geologic setting and stratigraphic framework are known from previous work by Dibblee (1954, 1996), Woodard (1963), Kerr (1982), Winker (1987), Kerr and Kidwell (1991), Winker and Kidwell (1986; 1996), and others. We have analyzed Upper Miocene to lower Pliocene strata exposed in a conformable section in Split Mt. Gorge, including (in order from the base; nomenclature of Winker and Kidwell, 1996): (1) Split Mt. Group: Red Rock Fm alluvial sandstone; Elephant Trees alluvial conglomerate; and lower megabreccia unit; and (2) lower part of Imperial Group, including: Fish Creek Gypsum; proximal to distal turbidites of the Latrania Fm and Wind Caves Mbr of Deguynos Fm; upper megabreccia unit; marine mudstone and rhythmites of the Mud Hills Mbr (Deguynos Fm); and the basal part of the Yuha Mbr (Deguynos Fm). Measured thickness from the base of the Elephant Trees Cgl to the base of the Yuha Mbr is about 1050 m, consistent with previous measurements of Winker (1987). Paleomagnetic samples were collected at approximately 10 m intervals throughout this section. The upper portion of our sampled section overlaps with the lower part of the section sampled for magnetostratigraphic study by Opdyke et al. (1977) and Johnson et al. (1983). They interpreted the base of their section to be about 4.3 Ma, and calculated an average sedimentation rate of approximately 5.5 mm/yr for the lower part of their section. Good-quality preliminary results from 15 paleomagnetic sites distributed throughout our sampled section permit preliminary identification of 6 polarity zones. Based on regional mapping and stratigraphic correlations (Winker and Kidwell, 1996) and extrapolation of the Johnson et al. (1983) sedimentation rates, we tentatively correlate two normal-polarity intervals in the lower part of our section to Chrons C3An.1n and C3An.2n of the geomagnetic polarity time scale of Cande and Kent (1995). If correct, this result would suggest that the lowest reversed-polarity portion of the Red Rock Fm near the base of the section should be correlated to Chron C3Ar.2r, and would be between 6.57 and 6.94 Ma in age. An alternative, but less likely, correlation for the reverse-polarity interval at the base of the section would be with Chron C2Br (7.09-7.43 Ma). This has significant implications for the timing of earliest extension-related basin formation in the western Salton Trough, and potentially raises new questions about the relationship of the Red Rock and Elephant Trees Formations to the Alverson Volcanics (22-14 Ma; Ruisaard, 1979; Kerr, 1982). These preliminary results will be tested and refined with a complete analysis of the remaining samples.

A climatological study of the associated weather events to Cut-off low systems in the Southwestern Europe and Northern Africa

NASA Astrophysics Data System (ADS)

Nieto, R.; Gimeno, L.; de La Torre, L.; Tesouro, M.; Añel, J.; Ribera, P.

2003-04-01

Cut-off low-pressure systems-COLS- are usually closed circulations at middle and upper troposphere developed from a deep trough in the westerlies. As general rule troposphere below COLs is unstable and convective severe events can occur as a function of the surface conditions. COLs can bring moderate to heavy rainfall over large areas. In particular they are among the most important weather systems that affect Southern Europe and Northern Africa and responsible for some of the most catastrophic weather events in terms of precipitation rate. In this study we identify COLs systems in Southwestern Europe and Northern Africa for a 41-year period (1958 to 1998) using an approach based in imposing the three main physical characteristics of the conceptual model of COL (a. closed circulation and minimum of geopotential, minimum of equivalent thickness, and two two baroclinic zones, one in front of the low and the other behind the low). Data from NCAR-NCEP reanalysis were used. The objective was to check the expected weather events according to the conceptual model of COL in an area where precipitation due to COL is relevant. In general terms results confirm expected weather events: a frontal cloud band on the leading edge of an upper level low that is usually thick enough to produce precipitation. Over cold surface there is no convection, and therefore no showers occur. Over Sea, moderate to heavy showery precipitation is frequent. The heaviest precipitation occur when convective cells are observed in the centre and over warm ocean, fall flash flood is frequent.

Sedimentology of paleochannels on foreland coastal plain, Judith River Formation (upper Cretaceous), southeast Alberta

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koster, E.H.

1984-04-01

The upper 90 m (295 ft) of the sub-Bearpaw Judith River Formation, continuously exposed in the badlands along the Red Deer River 185 km (115 mi) east of Calgary, is famous for the unrivaled assemblage of dinosaur fossils. Dinosaur Provincial Park presents are a rare opportunity to view the architecture of a foreland coastal-plain sequence as well as to clarify the origin and distribution of subbituminous coal zones and gas reservoirs associated with this formation across southeast Alberta. The distal reaches of paleodrainage from the developing Cordillera to the Western Interior seaway are being examined by north-south traversed across themore » badlands. Sharp-based paleochannel units, enclosed by rooted, olive-gray mudstone sequences that are commonly 4-6 m (13-20 ft) thick, vary between 2 end members. The first contains laterally accreted sand-mud couplets with abundant macrofloral debris, and represents cyclical, low-energy growth of point bars, possible with an estuarine influence. The second, mainly comprising cosets of large trough cross-beds with mudstone intraclasts, was formed by episodic aggradation of high-energy systems. An intermediate composite type displays evidence for an energy increase as channel sinuosity decreased. This variation in paleochannel type is attributed to alternating alluviation/rejuvenation associated with an unstable base level. Coal zones and potential reservoirs appear to be associated with the transgressive and regressive phases, respectively, of the Bearpaw coast. Amalgamation of paleochannels - marked by laterally extensive horizons of bone fragments, lithic and intraclastic gravel - is more common seaward over the axial region of the Sweetgrass arch.« less

Stress Fields Along Okinawa Trough and Ryukyu Arc Inferred From Regional Broadband Moment Tensors

NASA Astrophysics Data System (ADS)

Kubo, A.; Fukuyama, E.

2001-12-01

Most shallow earthquakes along Okinawa trough and Ryukyu arc are relatively small (M<5.5). Focal mechanism estimations for such events were difficult due to insufficient dataset. However, this situation is improved by regional broadband network (FREESIA). Lower limit of magnitude of the earthquakes determined becomes 1.5 smaller in M{}w than that of Harvard moment tensors. As a result, we could examine the stress field in more detail than Fournier et al.(2001, JGR, 106, 13751-) did based on surface geology and teleseismic moment tensors. In the NE Okinawa trough, extension axes are oblique to the trough strike, while in SW Okinawa trough, they are perpendicular to the trough. Fault type in SW is normal fault and gradually changes to mixture of normal and strike slip toward NE. In the Ryukyu arc, extension axes are parallel to the arc. Although this feature is not clear in the NW Ryukyu arc, arc parallel extension may be a major property of entire arc. Dominant fault type is normal fault and several strike slips with the same extensional component are included. The volcanic train is located at the edge of arc parallel extension field faced A simple explanation of the arc parallel extension is the response to the opening motion of the Okinawa trough. Another possible mechanism is forearc movement due to oblique subduction which is enhanced in SW. We consider that the Okinawa trough and the Ryukyu arc are independent stress provinces.

Climatic and hydrologic aspects of the 2008 Midwest floods

NASA Astrophysics Data System (ADS)

Budikova, D.; Coleman, J.; Strope, S. A.

2010-12-01

Between May and June 2008 the Midwest region of the United States (U.S.) experienced record flooding. The event was produced by distinct hydroclimatic conditions that included saturated antecedent soil moisture conditions and atmospheric circulation that guided moist air from the Gulf of Mexico into the area between late May and mid-June. The latter included a well-developed trough over the central/west U.S., a strong Great Plains Low Level Jet (GPLLJ), and unseasonably strong westerlies that promoted upper level divergence in regions of positive vorticity advection. The flooding coincided with a strongly negative phase of the North Atlantic Oscillation linked to the strength of the GPLLJ. The atmospheric flow contributed to flooding within three river basins across nine states. Iowa, southern Wisconsin, and central Indiana located within the Upper Mississippi River Basin (UMRB) and the Wabash River Basin were most impacted and also recorded the greatest anomalies in rainfall. Record rainfall, persistent multi-day precipitation events, high frequency of localized high-intensity rainfall events all contributed to the severity of the flooding. Conditions peaked between May 21 and June 13 when rain fell somewhere within the region each day. River discharge rates reached record levels in June at many locations; return periods throughout Iowa, southern Wisconsin and in central Indiana were estimated to exceed 100 years, and often times 200 years. Record river stage levels were observed during this time in similar areas. Conditions began to recover into July and August. The timing of occurrence of the precipitation and hydrological anomalies towards late spring and into early summer in the Midwest was rather unusual. The 2008 flood event occurred 15 years after the infamous 1993 event. The importance of its occurrence is underscored by the observed increasing trends in extreme and flood-related precipitation characteristics during the 20th century and the anticipated changes under future anthropogenic warming scenarios. If changes in such extremes can be understood or even anticipated, society can begin to take measures towards proactive adaptation and risk management to limit future impacts.

Ground Water Levels for NGEE Areas A, B, C and D, Barrow, Alaska, 2012-2014

DOE Data Explorer

Anna Liljedahl; Cathy Wilson

2015-06-08

Ice wedge polygonal tundra water levels were measured at a total of 45 locations representing polygon centers and troughs during three summers. Early season water levels, which were still affected by ice and snow, are represented by manual measurements only. Continuous (less than hourly) measurements followed through early fall (around mid-Sep). The data set contains inundation depth (cm), absolute water level and local ground surface elevation (masl).

Trough Coating Solar Cells Without Spillover

NASA Technical Reports Server (NTRS)

Heaps, J. D.

1986-01-01

Problem with trough coating of silicon on ceramic - spillover of molten silicon - overcome by combination of redesigned heaters and tiltable trough. Modifications make it possible to coat virtually any length of ceramic with film of solar-cell-grade silicon. Previously, maximum length coated before spillover occurred was 2 inches (5.1 cm).

Labeatis Trough

NASA Technical Reports Server (NTRS)

2006-01-01

2 July 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of a trough cutting across a dust-covered plain in the Labeatis Fossae region of Mars. Boulders derived from the layered exposures near the top of the trough walls are resting on the floor, and in some locations, the sloping sidewalls of the dusty trough.

Location near: 22.1oN, 94.5oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Spring

Technical Manual for the SAM Physical Trough Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wagner, M. J.; Gilman, P.

2011-06-01

NREL, in conjunction with Sandia National Lab and the U.S Department of Energy, developed the System Advisor Model (SAM) analysis tool for renewable energy system performance and economic analysis. This paper documents the technical background and engineering formulation for one of SAM's two parabolic trough system models in SAM. The Physical Trough model calculates performance relationships based on physical first principles where possible, allowing the modeler to predict electricity production for a wider range of component geometries than is possible in the Empirical Trough model. This document describes the major parabolic trough plant subsystems in detail including the solar field,more » power block, thermal storage, piping, auxiliary heating, and control systems. This model makes use of both existing subsystem performance modeling approaches, and new approaches developed specifically for SAM.« less

Pennsylvanian-Permian tectonism in the Great Basin: The Dry Mountain trough and related basins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snyder, W.S.; Spinosa, C.; Gallegos, D.M.

1991-02-01

Pennsylvanian-Permian tectonism affected the continental margin of western North America from the Yukon to the Mojave Desert. Specific signatures of this tectonism include local angular unconformities, regional disconformities, renewed outpouring of clastic debris from a reactivated Antler and related highlands, and development of deeper water basins with anoxic sediments deposited below wave base. The basins formed include Ishbel trough (Canada), the Wood River basin (Idaho), Cassia basin, Ferguson trough, Dry Mountain trough (all Nevada), and unnamed basins in Death Valley-Mojave Desert region. The Dry Mountain trough (DMT) was initiated during early Wolfcampian and received up to 1,200 m of sedimentmore » by the late Leonardian. The lower contact is a regional unconformity with the Ely Limestone, or locally with the Diamond Peak or Vinini formations. Thus, following a period of localized regional uplift that destroyed the Ely basin, portions of the uplifted and exposed shelf subsided creating the Dry Mountain trough. Evidence suggesting a tectonic origin for the DMT includes (1) high subsidence rates (60-140 m/m.y.); (2) renewed influx of coarse clastic debris from the Antler highlands: (3) possible pre-Early Permian folding, thrusting, and tilting within the highlands; and (4) differential subsidence within the Dry Mountain trough, suggesting the existence of independent fault blocks.« less

Present-day erosion of Martian polar terrain by the seasonal CO2 jets

NASA Astrophysics Data System (ADS)

Portyankina, Ganna; Hansen, Candice J.; Aye, Klaus-Michael

2017-01-01

Here we report on the detection of new dendritic troughs created by the seasonal CO2 jet activity over several Martian years. According to Kieffers hypothesis (Kieffer, 2007) in Martian polar areas seasonal CO2 ice sublimation creates gas jets that deposit fans of mineral dust and sand on top of the CO2 ice. These jets and the related sub-ice gas flows are believed to carve troughs in the underlying polar deposits which, after multiple repetitions of this process throughout Martian spring seasons, create araneiform terrains. The High Resolution Imaging Science Experiment (HiRISE) on the Mars Reconnaissance Orbiter (MRO) detected the new troughs during its campaign for seasonal monitoring of the polar areas. The newly detected dendritic troughs are small shallow branching troughs (≈ 1.4 m wide) similar to the seasonal furrows previously detected in the northern hemisphere (Bourke, 2013). The essential difference between the new troughs and furrows lies in the fact that the troughs in the south are persistent while the northern furrows are erased each Martian year by the sand movement due to summer winds. From year to year the new southern troughs extend and develop new tributaries and their overall geometry turns from linear to dendritic, a characteristic shared with araneiform terrains. We believe that furrows have the same origin as the southern dendritic troughs but do not develop into dendritic shapes because of the high mobility of the dune material into which they are carved. Several locations where new dendritic troughs are observed lie in the vicinity of dunes. This gives us an observational indication that presence of erosive sand material is an important factor in creating (or at least starting) erosive processes that lead to the formation of dendritic troughs. By extrapolation the same mechanism should be acting to create the much larger araneiform terrains. Detection of the present day erosion working in polar areas and creating new topographical features is important for understanding of the processes that shape polar areas. Several years of HiRISE observations provide us with the information about the current rate of erosion and hence help estimate minimum ages of the araneiforms and the surface into which they are carved to be 1.3 × 103 Martian years.

Petroleum geology and resources of the Volga-Ural province, U.S.S.R.

USGS Publications Warehouse

Peterson, James A.; Clarke, James W.

1983-01-01

The Volga-Ural petroleum province is, in general, coincident with the Volga-Ural regional high, a broad upwarp of the east-central part of the Russian (East European) Platform. The central part of the province is occupied by the Tatar arch, which contains the major share of the oilfields of the province. The Komi-Perm arch forms the northeastern part of the regional high, and the Zhigulevsko-Pugachev and Orenburg arches make up the southern part. These arches are separated from one another by elongate downwarps. The platform cover overlies an Archean crystalline basement and consists of seven main sedimentation cycles. (1) Riphean (lower Bavly) continental sandstone, shale, and conglomerate beds, from 500 to 5,000 m thick, were deposited in aulacogens. (2) Vendian (upper Bavly) continental and marine shale and sandstone are up to 3,000 m thick. (3) Middle Devonian-Tournaisian transgressive deposits, which are sandstone, siltstone, and shale in the lower part and carbonates and abundant reefs in the upper part, range from 300 to 1,000 m in thickness. The upper carbonate part includes the Kamsko-Kinel trough system, which consists of narrow, interconnected, deepwater troughs. (4) The Visean-Namurian-Bashkirian cycle began with deposition of Visean clastic deposits, which draped over reefs of the previous cycle and filled in an erosional relief that had formed in some places on the sediments of the previous cycle. The Visean clastic deposits are overlain by marine carbonate beds. The cycle is from 50 to 800 m thick. (5) The lower Moscovian-Lower Permian cycle consists of 1,000 to 3,000 m of terrigenous clastic deposits and marine carbonate beds. (6) The upper Lower Permian-Upper Permian cycle reflects the maximum growth of the Ural Mountains and the associated Ural foredeep. Evaporite deposits were first laid down, followed by marine limestones and dolomites, which intertongue eastward with clastic sediments from the Ural Mountains. (7) Continental red beds of Triassic age and mixed continental and marine clastic beds of Jurassic and Cretaceous age were deposited on the western, southwestern, and northern margins of the Russian Platform; they are generally absent in the Volga-Ural province, however. Approximately 600 oilfields and gasfields and 2,000 pools have been found in the Volga-Ural province. Nine productive sequences are recognized; these are, in general, the same as the sedimentation cycles, although some subdivisions have been added. The clastic section of Middle and early Late Devonian age contains the major recoverable oil accumulations, including the supergiant Romashkino field. Cumulative production to 1980 is estimated at 30 to 35 billion barrels of oil equivalent, identified reserves at about 10 billion barrels of oil equivalent, and undiscovered resources at about 7 billion barrels of oil equivalent. Identified reserves of natural gas are estimated at 100 trillion cubic feet and undiscovered resources at 63 trillion cubic feet.

Shoreface response and recovery to Hurricane Sandy: Fire Island, NY

USGS Publications Warehouse

Nelson, Timothy R.; Hapke, Cheryl J.; Wang, Ping; Rosati, Julie D.; Cheng, Jun

2015-01-01

The shoreface of Fire Island was extensively modified by Hurricane Sandy and subsequent storms in the following winter months. The changes were evaluated using various morphometrics of the shoreface from four bathymetric surveys, one prior to Hurricane Sandy, and three over the course of twenty months following Sandy. The datasets show that the nearshore bar system moved offshore to deeper water depths following Hurricane Sandy with volume lost from the subaerial beach and surfzone. Following the offshore shift, the nearshore bar system increased in size, the trough deepened, and there has been gradual landward movement of the nearshore bar. The steepening of the upper shoreface, landward translation of the profile, and loss of sediment is indicative of barrier island transgression.

Ozone maxima over Southern Africa: A mid-latitude link

NASA Technical Reports Server (NTRS)

Barsby, Jane; Diab, Roseanne D.

1994-01-01

The relationship between patterns of total ozone and day-to-day weather was explored over South Africa for the period 1987 to 1988. Generally, there was a fairly poor relationship (variance less than 20 percent) between total ozone and the heights of the 100, 300 and 500 hPa geopotential heights at 5 South African stations. However, over a shorter period, October to December 1988, fluctuations in the height of the 300 hPa surface accounted for 53 percent of the variance in total ozone at Cape Town. High ozone amounts are associated with the lowering of the 300 hPa surface in the presence of an upper-air trough. The role of the mid-latitude westerly waves in this respect is discussed.

Extensive deposits on the Pacific plate from Late Pleistocene North American glacial lake outbursts

USGS Publications Warehouse

Normark, W.R.; Reid, J.A.

2003-01-01

One of the major unresolved issues of the Late Pleistocene catastrophic-flood events in the northwestern United States (e.g., from glacial Lake Missoula) has been what happened when the flood discharge reached the ocean. This study compiles available 3.5-kHz high-resolution and airgun seismic reflection data, long-range sidescan sonar images, and sediment core data to define the distribution of flood sediment in deepwater areas of the Pacific Ocean. Upon reaching the ocean at the mouth of the Columbia River near the present-day upper continental slope, sediment from the catastrophic floods continued flowing downslope as hyperpycnally generated turbidity currents. The turbidity currents resulting from the Lake Missoula and other latest Pleistocene floods followed the Cascadia Channel into and through the Blanco Fracture Zone and then flowed west to the Tufts Abyssal Plain. A small part of the flood sediment, which was stripped off the main flow at a bend in the Cascadia Channel at its exit point from the Blanco Fracture Zone, continued flowing more than 400 km to the south and reached the Escanaba Trough, a rift valley of the southern Gorda Ridge. Understanding the development of the pathway for the Late Pleistocene flood sediment reaching Escanaba Trough provides insight for understanding the extent of catastrophic flood deposits on the Pacific plate.

Observed Hydrographic Variability Connecting the Continental Shelf to the Marine-Terminating Glaciers of Uummannaq Bay, West Greenland

NASA Astrophysics Data System (ADS)

Sutherland, D.; de Steur, L.; Nash, J. D.; Shroyer, E.; Mickett, J.

2016-02-01

Large-scale changes in ocean forcing, such as increased upper ocean heat content or variations in subpolar gyre circulation, are commonly implicated as factors causing the widespread retreat of Greenland's outlet glaciers. A recent surge in observational and modeling studies has shown how temperature increases and a changing subglacial discharge determine melt rates at glacier termini, driving a vigorous buoyancy-driven circulation. However, we still lack knowledge of what controls ambient water properties in the fjords themselves, i.e., how does the subpolar gyre communicate across the continental shelf towards the glacier termini. Here, we present a two-year mooring record of hydrographic variability in the Uummannaq Bay region of west Greenland. We focus on observations inside Rink Isbræ and Kangerlussuup Sermia fjords coupled with an outer mooring located in the submarine trough cutting across the shelf. We show how water properties vary seasonally inside the fjords and how they connect to variability in the trough. The two fjords exhibit large differences in temperature and salinity variability, which is possibly due to differences in the plume circulation driven by the glaciers themselves. We put these limited observations in temporal context by comparing them with observations from the nearby Davis Strait time array, and spatial context by comparing them with recent mooring records from Sermilik Fjord in southeast Greenland.

C IV BROAD ABSORPTION LINE ACCELERATION IN SLOAN DIGITAL SKY SURVEY QUASARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grier, C. J.; Brandt, W. N.; Trump, J. R.

2016-06-20

We present results from the largest systematic investigation of broad absorption line (BAL) acceleration to date. We use spectra of 140 quasars from three Sloan Digital Sky Survey programs to search for global velocity offsets in BALs over timescales of ≈2.5–5.5 years in the quasar rest frame. We carefully select acceleration candidates by requiring monolithic velocity shifts over the entire BAL trough, avoiding BALs with velocity shifts that might be caused by profile variability. The C iv BALs of two quasars show velocity shifts consistent with the expected signatures of BAL acceleration, and the BAL of one quasar shows amore » velocity-shift signature of deceleration. In our two acceleration candidates, we see evidence that the magnitude of the acceleration is not constant over time; the magnitudes of the change in acceleration for both acceleration candidates are difficult to produce with a standard disk-wind model or via geometric projection effects. We measure upper limits to acceleration and deceleration for 76 additional BAL troughs and find that the majority of BALs are stable to within about 3% of their mean velocities. The lack of widespread acceleration/deceleration could indicate that the gas producing most BALs is located at large radii from the central black hole and/or is not currently strongly interacting with ambient material within the host galaxy along our line of sight.« less

Troughs on Martian Ice Sheets: Analysis of Their Closure and Mass Balance

NASA Technical Reports Server (NTRS)

Fountain, A.; Kargel, J.; Lewis, K.; MacAyeal, D.; Pfeffer, T.; Zwally, J.

2000-01-01

At the Copenhagen workshop on Martian polar processes, Ralf Greve commented that the flow regime surrounding scarps and troughs of the Martian polar ice sheets cannot be modeled using traditional "plan view" ice-sheet models. Such models are inadequate because they typically use reduced equations that embody certain simplifications applicable only to terrestrial ice sheets where the upper ice sheet surface is smooth. In response to this suggestion, we have constructed a 2-dimensional, time dependent "side view" (two spatial dimensions: one horizontal, one vertical) model of scarp closure that is designed to overcome the difficulties described by Greve. The purpose of the model is to evaluate the scales of stress variation and styles of flow closure so as to estimate errors that may be encountered by "plan view" models. We show that there may be avenues whereby the complications associated with scarp closure can be overcome in "plan view" models through appropriate parameterizations of 3-dimensional effects. Following this, we apply the flow model to simulate the evolution of a typical scarp on the North Polar Cap of Mars. Our simulations investigate: (a) the role of "radiation trapping" (see our companion abstract) in creating and maintaining "spiral-like" scarps on the ice sheet, (b) the consequences of different flowlaws and ice compositions on scarp evolution and, in particular, scarp age, and (c) the role of dust and debris in scarp evolution.

Effects of monsoon trough interannual variation on tropical cyclogenesis over the western North Pacific

NASA Astrophysics Data System (ADS)

Cao, Xi; Li, Tim; Peng, Melinda; Chen, Wen; Chen, Guanghua

2014-06-01

The western North Pacific monsoon trough (MT) exhibits marked interannual variation (IAV) associated with El Niño-Southern Oscillation forcing. The role of MT IAV in tropical cyclone (TC) development was investigated using the Advanced Research Weather Research and Forecasting model placed on a beta plane. It was found that MT IAV has a great influence on vortex development. In strong years, the MT provides more favorable environmental conditions—primarily through enhanced low-level vorticity, convergence and midlevel moisture—for TC formation and vice versa in weak years. Sensitivity experiments that separated the dynamic and thermodynamic (moisture) factors from strong MT IAV showed that the thermodynamic impact associated with MT IAV is comparable to the dynamic impact.

Should intake of carbon monoxide be used as a guide to intake of other smoke constituents?

PubMed Central

Ashton, H; Stepney, R; Thompson, J W

1981-01-01

The relation between blood carboxyhaemoglobin (COHb) and plasma nicotine concentrations was studied in a group of 12 smokers smoking cigarettes of three levels of standard delivery. While the intake of carbon monoxide from a single cigarette was unrelated to the intake of nicotine, presmoking "trough" concentrations of the two substances (reflecting longer-term exposure) were highly correlated. Various other measures of nicotine exposure were at best only moderately correlated with blood nicotine concentrations. Thus trough COHb concentrations might be used to provide a reliable indication of the exposure to nicotine of individual smokers smoking the same type of cigarette, and of the relative exposure to nicotine of populations smoking cigarettes of different standard deliveries. PMID:6778547

Topography and Stratigraphy of the Northern Martian Polar Layered Deposits Using Photoclinometry, Stereogrammetry, and MOLA Altimetry

USGS Publications Warehouse

Fenton, L.K.; Herkenhoff, K. E.

2000-01-01

We present two photoclinometric profiles across a trough in the martian northern polar layered terrain. Complications caused by albedo variations were avoided by using an early springtime Viking image with a thin cover of seasonal CO2 frost. The topographic profiles were constrained with stereogrammetric elevations derived from summertime Viking images of the same region. We find that the photoclinometric profiles are consistent with a nearby MOLA (Mars Orbiter Laser Altimeter) track crossing the same polar trough. The trough is asymmetric, with higher relief and a steeper slope on the equatorward-facing wall. Individual layers are subdued and difficult to observe in the profiles. A decrease in both relief and elevation toward the eastern end of the trough suggests that layers become thinner to the east. Declining equatorward slopes in the eastern portion of the trough imply that erosion rates have varied along the trough. The variation in erosion rate may be linked to the change in layer thickness along the trough. Layers have an average thickness of 19??8 m in the center of the trough and 59??32 m on the northern wall. The northern wall is most likely composed of thinner layers that are obscured. To first order, we find that a 19-m layer requires 16,000 years of deposition to form. Although this timescale does not coincide with orbital variation periods of 105 and 106 years, deposition rates may not be constant and thus the 16,000-year layer formation time does not preclude layer formation during part of each orbital oscillation. ?? 2000 Academic Press.

Meta-analysis of medical intervention for normal tension glaucoma.

PubMed

Cheng, Jin-Wei; Cai, Ji-Ping; Wei, Rui-Li

2009-07-01

To evaluate the intraocular pressure (IOP) reduction achieved by the most frequently prescribed antiglaucoma drugs in patients with normal tension glaucoma (NTG). Systematic review and meta-analysis. Fifteen randomized clinical trials reported 25 arms for peak IOP reduction, 16 arms for trough IOP reduction, and 13 arms for diurnal curve IOP reduction. Pertinent publications were identified through systematic searches of PubMed, EMBASE, and the Cochrane Controlled Trials Register. The patients had to be diagnosed as having NTG. Methodological quality was assessed by the Delphi list on a scale from 0 to 18. The pooled 1-month IOP-lowering effects were calculated using the 2-step DerSimonian and Laird estimate method of the random effects model. Absolute and relative reductions in IOP from baseline for peak and trough moments. Quality scores of included studies were generally high, with a mean quality score of 12.7 (range, 9-16). Relative IOP reductions were peak, 15% (12%-18%), and trough, 18% (8%-27%) for timolol; peak, 14% (8%-19%), and trough, 12% (-7% to 31%) for dorzolamide; peak, 24% (17%-31%), and trough, 11% (7%-14%) for brimonidine; peak, 20% (17%-24%), and trough, 20% (18%-23%) for latanoprost; peak, 21% (16%-25%), and trough, 18% (14%-22%) for bimatoprost. The differences in absolute IOP reductions between prostaglandin analogues and timolol varied from 0.9 to 1.0 mmHg at peak and -0.1 to 0.2 mmHg at trough. Latanoprost, bimatoprost, and timolol are the most effective IOP-lowering agents in patients with NTG.

A Mediterranean nocturnal heavy rainfall and tornadic event. Part I: Overview, damage survey and radar analysis

NASA Astrophysics Data System (ADS)

Bech, Joan; Pineda, Nicolau; Rigo, Tomeu; Aran, Montserrat; Amaro, Jéssica; Gayà, Miquel; Arús, Joan; Montanyà, Joan; der Velde, Oscar van

2011-06-01

This study presents an analysis of a severe weather case that took place during the early morning of the 2nd of November 2008, when intense convective activity associated with a rapidly evolving low pressure system affected the southern coast of Catalonia (NE Spain). The synoptic framework was dominated by an upper level trough and an associated cold front extending from Gibraltar along the Mediterranean coast of the Iberian Peninsula to SE France, which moved north-eastward. South easterly winds in the north of the Balearic Islands and the coast of Catalonia favoured high values of 0-3 km storm relative helicity which combined with moderate MLCAPE values and high shear favoured the conditions for organized convection. A number of multicell storms and others exhibiting supercell features, as indicated by Doppler radar observations, clustered later in a mesoscale convective system, and moved north-eastwards across Catalonia. They produced ground-level strong damaging wind gusts, an F2 tornado, hail and heavy rainfall. Total lightning activity (intra-cloud and cloud to ground flashes) was also relevant, exhibiting several classical features such as a sudden increased rate before ground level severe damage, as discussed in a companion study. Remarkable surface observations of this event include 24 h precipitation accumulations exceeding 100 mm in four different observatories and 30 minute rainfall amounts up to 40 mm which caused local flash floods. As the convective system evolved northward later that day it also affected SE France causing large hail, ground level damaging wind gusts and heavy rainfall.

Clinical Utility of Random Anti–Tumor Necrosis Factor Drug–Level Testing and Measurement of Antidrug Antibodies on the Long‐Term Treatment Response in Rheumatoid Arthritis

PubMed Central

Jani, Meghna; Chinoy, Hector; Warren, Richard B.; Griffiths, Christopher E. M.; Plant, Darren; Fu, Bo; Morgan, Ann W.; Wilson, Anthony G.; Isaacs, John D.; Hyrich, KimmeL.; Prouse, P. J.; Moitra, R. K.; Shawe, D. J.; Nisar, M.; Fairburn, K.; Nixon, J.; Barnes, T.; Hui, M.; Coady, D.; Wright, D.; Morley, C.; Raftery, G.; Bracewell, C.; Bridges, M.; Armstrong, D.; Chuck, A. J.; Hailwood, S.; Kumar, N.; Ashok, D.; Reece, R.; O'Reilly, S. C.; Ding, T.; Badcock, L. J.; Deighton, C. M.; Raj, N.; Regan, M. R.; Summers, G. D.; Williams, R. A.; Lambert, J. R.; Stevens, R.; Wilkinson, C.; Kelly, C. A.; Hamilton, J.; Heycock, C. R.; Saravanan, V.; Cope, A.; Garrood, T.; Ng, N.; Kirkham, B.; Green, M.; Gough, A.; Lawson, C.; Das, D.; Borbas, E.; Wazir, T.; Emery, P.; Bingham, S.; Bird, H. A.; Conaghan, P.G.; Pease, C. T.; Wakefield, R. J.; Buch, M.; Bruce, I.; Gorodkin, R.; Ho, P.; Parker, B.; Smith, W.; Jenkins, E.; Mukhtyar, C.; Gaffney, K.; Macgregor, A. J.; Marshall, T.; Merry, P.; DeSilva, C.; Birrell, F. N.; Crook, P. R.; Szebenyi, B.; Bates, D.; James, D.; Gillott, T.; Alvi, A.; Grey, C.; Browning, J.; McHale, J. F.; Gaywood, I.C.; Jones, A. C.; Lanyon, P.; Pande, I.; Doherty, M.; Gupta, A.; Courtney, P. A.; Srikanth, A.; Abhishek, A.; Das, L.; Pattrick, M.; Snowden, H. N.; Bowden, A. P.; Smith, E. E.; Klimiuk, P.; Speden, D. J.; Naz, S.; Ledingham, J. M.; Hull, R. G.; McCrae, F.; Cooper, A.; Young‐Min, S. A.; Wong, E.; Shaban, R.; Woolf, A. D.; Davis, M.; Hutchinson, D.; Endean, A.; Mewar, D.; Tunn, E. J.; Nelson, K.; Kennedy, T. D.; Dubois, C.; Pauling, J.; Korendowych, E.; Jenkinson, T.; Sengupta, R.; Bhalla, A.; McHugh, N.; O'Neil, T.; Herrick, A. L.; Jones, A. K.; Cooper, R. G.; Dixon, W. G.; Harrison, B.; Buckley, C. D.; Carruthers, D. C.; Elamanchi, R.; Gordon, P. C.; Grindulis, K. A.; Khattak, F.; Raza, K.; Situnayake, K.; Akil, M.; Till, S.; Dunkley, L.; Tattersall, R.; Kilding, R.; Tait, T.; Maxwell, J.; Till, S.; Kuet, K.-P.; Plant, M. J.; Clarke, F.; Fordham, J. N.; Tuck, S.; Pathare, S. K.; Paul, A.; Marguerie, C. P.; Rigby, S. P.; Dunn, N.; Abbas, I.; Filer, C.; Abernethy, V. E.; Clewes, A. R.; Dawson, J. K.; Kitas, G.; Erb, N.; Klocke, R.; Whallett, A. J.; Douglas, K.; Pace, A.; Sandhu, R.; John, H.; Shand, L.; Lane, S.; Foster, H.; Griffiths, B.; Griffiths, I.; Kay, L.; Ng, W.-F.; Platt, P. N.; Walker, D. J.; Peterson, P.; Lorenzi, A.; Friswell, M.; Thompson, B.; Lee, M.; Pratt, A.; Hopkinson, N. D.; Dunne, C. A.; Quilty, B.; Marks, J.; Mukherjee, S.; Mulherin, D.; Chalam, S. V.; Price, T.; Sheeran, T.; Venkatachalam, S.; Baskar, S.; Al- Allaf, W.; McKenna, F.; Shah, P.; Filer, A.; Bowman, S. J.; Jobanputra, P.; Rankin, E. C.; Allen, M.; Chaudhuri, K.; Dubey, S.; Price‐Forbes, A.; Ravindran, J.; Samanta, A.; Sheldon, P.; Hassan, W.; Francis, J.; Kinder, A.; Neame, R.; Moorthy, A.; Bukhari, M.; Ottewell, L.; Palkonyai, E.; Hider, S.; Hassell, A.; Menon, A.; Dowson, C.; Kamath, S.; Packham, J.; Dutta, S.; Price, S.; Roddy, E.; Paskins, Z.; O'Reilly, D. T.; Rajagopal, V.; Bhagat, S.; Chattopadhyay, C. B.; Green, M.; Quinn, D.; Isdale, A.; Brown, A.; Saleem, B.; Foo, B.; Al Saffar, Z.; Koduri, G.

2015-01-01

Objective To investigate whether antidrug antibodies and/or drug non‐trough levels predict the long‐term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. Methods A total of 331 patients from an observational prospective cohort were selected (160 patients treated with adalimumab and 171 treated with etanercept). Antidrug antibody levels were measured by radioimmunoassay, and drug levels were measured by enzyme‐linked immunosorbent assay in 835 serial serum samples obtained 3, 6, and 12 months after initiation of therapy. The association between antidrug antibodies and drug non‐trough levels and the treatment response (change in the Disease Activity Score in 28 joints) was evaluated. Results Among patients who completed 12 months of followup, antidrug antibodies were detected in 24.8% of those receiving adalimumab (31 of 125) and in none of those receiving etanercept. At 3 months, antidrug antibody formation and low adalimumab levels were significant predictors of no response according to the European League Against Rheumatism (EULAR) criteria at 12 months (area under the receiver operating characteristic curve 0.71 [95% confidence interval (95% CI) 0.57, 0.85]). Antidrug antibody–positive patients received lower median dosages of methotrexate compared with antidrug antibody–negative patients (15 mg/week versus 20 mg/week; P = 0.01) and had a longer disease duration (14.0 versus 7.7 years; P = 0.03). The adalimumab level was the best predictor of change in the DAS28 at 12 months, after adjustment for confounders (regression coefficient 0.060 [95% CI 0.015, 0.10], P = 0.009). Etanercept levels were associated with the EULAR response at 12 months (regression coefficient 0.088 [95% CI 0.019, 0.16], P = 0.012); however, this difference was not significant after adjustment. A body mass index of ≥30 kg/m2 and poor adherence were associated with lower drug levels. Conclusion Pharmacologic testing in anti–tumor necrosis factor–treated patients is clinically useful even in the absence of trough levels. At 3 months, antidrug antibodies and low adalimumab levels are significant predictors of no response according to the EULAR criteria at 12 months. PMID:26109489

9 CFR 82.21 - Vehicles, cages, coops, containers, troughs, and other equipment used for infected poultry.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., troughs, and other equipment used for infected poultry. 82.21 Section 82.21 Animals and Animal Products... ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS EXOTIC NEWCASTLE DIS- EASE (END) AND CHLAMYDIOSIS Chlamydiosis in Poultry § 82.21 Vehicles, cages, coops, containers, troughs, and other equipment used for...

Evolution of the Outflows in NGC 3516

NASA Astrophysics Data System (ADS)

Dunn, Jay P.; Parvaresh, Rozhin; Kraemer, S. B.; Crenshaw, D. Michael

2018-02-01

We analyze the 2011 HST/COS spectrum of the Seyfert 1 galaxy NGC 3516, which demonstrates clear changes in one of the intrinsic absorption troughs (component 5), slight evidence of change in a second trough (component 6), and the appearance of a new absorption trough (component 9). We interpret both the changes and the appearance of the new trough as bulk motion across the line of sight. The implied lower limit on the transverse velocity of component 5 is 360 km s‑1, compared to the earlier 2001 HST/STIS spectrum, while the lower limits for components 6 and 9 are 920 km s‑1, based on 2009 FUSE data. Component 5 also exhibits a shift in velocity centroid. This is only the second known case of this behavior in a Seyfert galaxy. Due to the high quality of the HST/COS spectrum, we identify a previously undetected trough due to an excited state of Si II for component 1. In combination with the resonance trough of Si II and photoionization modeling, we directly determine the distance of the component 1 outflow to be 67.2 pc.

Geochemical and Sr-Nd-Pb-Li isotopic characteristics of volcanic rocks from the Okinawa Trough: Implications for the influence of subduction components and the contamination of crustal materials

NASA Astrophysics Data System (ADS)

Guo, Kun; Zhai, Shikui; Yu, Zenghui; Wang, Shujie; Zhang, Xia; Wang, Xiaoyuan

2018-04-01

The Okinawa Trough is an infant back-arc basin developed along the Ryukyu arc. This paper provides new major and trace element and Sr-Nd-Pb-Li isotope data of volcanic rocks in the Okinawa Trough and combines the published geochemical data to discuss the composition of magma source, the influence of subduction component, and the contamination of crustal materials, and calculate the contribution between subduction sediment and altered oceanic crust in the subduction component. The results showed that there are 97% DM and 3% EMI component in the mantle source in middle trough (MS), which have been influenced by subduction sediment. The Li-Nd isotopes indicate that the contribution of subduction sediment and altered oceanic crust in subduction component are 4 and 96%, respectively. The intermediate-acidic rocks suffer from contamination of continental crust material in shallow magma chamber during fractional crystallization. The acidic rocks in south trough have experienced more contamination of crustal material than those from the middle and north trough segments.

The noon and midnight mid-latitude trough as seen by Ariel 4

NASA Technical Reports Server (NTRS)

Tulunay, Y. K.; Grebowsky, J. M.

1978-01-01

The electron density data returned by the polar orbiting satellites Ariel 3 and Ariel 4 revealed that the midlatitude trough is one of the distinct large-scale features of the ionosphere at about 550 km. Recent work (e.g., Tulunay and Grebowsky, 1975) on the data included the investigation of the temporal development of the latitudinal position of the midlatitude electron density trough at dawn and dusk during the large magnetic storms of May 1967 and May 1972. Model calculations which assumed that the equatorial convection E-field varies in step with the Kp index reproduced on the average the observed behavior. In the present paper, trough observations made at noon and midnight during the period, 12-21 December 1971 which encompassed a relatively large magnetic storm are discussed. In this context, model calculations have been employed as a guide of average approximations of the actual situation in predicting the plasmapause location. It is also shown that the trough observed on the noon passes is not generally plasmapause-related as the nightside troughs are expected to be.

Efficacy and safety of extended- versus immediate-release pramipexole in Japanese patients with advanced and L-dopa-undertreated Parkinson disease: a double-blind, randomized trial.

PubMed

Mizuno, Yoshikuni; Yamamoto, Mitsutoshi; Kuno, Sadako; Hasegawa, Kazuko; Hattori, Nobutaka; Kagimura, Tatsuro; Sarashina, Akiko; Rascol, Olivier; Schapira, Anthony H V; Barone, Paolo; Hauser, Robert A; Poewe, Werner

2012-01-01

To compare the efficacy, safety, tolerability, and trough plasma levels of pramipexole extended-release (ER) and pramipexole immediate-release (IR), and to assess the effects of overnight switching from an IR to an ER formulation, in L-dopa-treated patients with Parkinson disease (PD). After a 1- to 4-week screening/enrollment, 112 patients who had exhibited L-dopa-related problems or were receiving suboptimal L-dopa dosage were randomized in double-blind, double-dummy, 1:1 fashion to pramipexole ER once daily or pramipexole IR 2 to 3 times daily for 12 weeks, both titrated to a maximum daily dose of 4.5 mg. Successful completers of double-blind treatment were switched to open-label pramipexole ER, beginning with a 4-week dose-adjustment phase. Among the double-blind treatment patients (n = 56 in each group), Unified Parkinson's Disease Rating Scale Parts II+III total scores decreased significantly from baseline and to a similar degree with pramipexole ER and IR formulations. In each group, 47 double-blind patients (83.9%) reported adverse events (AEs), requiring withdrawal of 3 ER patients (5.4%) and 2 IR patients (3.6%). Trough plasma levels at steady state (at the same doses and dose-normalized concentrations) were also similar with both formulations. Among open-label treatment patients (n = 53 from IR to ER), 83% were successfully switched (no worsening of PD symptoms) to pramipexole ER. In L-dopa-treated patients, pramipexole ER and pramipexole IR demonstrated similar efficacy, safety, tolerability, and trough plasma levels. Patients can be safely switched overnight from pramipexole IR to pramipexole ER with no impact on efficacy.

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia.

PubMed

Holmes, Natasha E; Turnidge, John D; Munckhof, Wendy J; Robinson, J Owen; Korman, Tony M; O'Sullivan, Matthew V N; Anderson, Tara L; Roberts, Sally A; Warren, Sanchia J C; Gao, Wei; Howden, Benjamin P; Johnson, Paul D R

2013-04-01

A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. aureus infections. Here, vancomycin serum trough levels and vancomycin AUC/MIC were evaluated in a "real-world" context by following a cohort of 182 patients with S. aureus bacteremia (SAB) and analyzing these parameters within the critical first 96 h of vancomycin therapy. The median vancomycin trough level at this time point was 19.5 mg/liter. There was a significant difference in vancomycin AUC/MIC when using broth microdilution (BMD) compared with Etest MIC (medians of 436.1 and 271.5, respectively; P < 0.001). Obtaining the recommended vancomycin target AUC/MIC of ≥ 400 using BMD was not associated with lower 30-day all-cause or attributable mortality from SAB (P = 0.132 and P = 0.273, respectively). However, an alternative vancomycin AUC/MIC of >373, derived using classification and regression tree analysis, was associated with reduced mortality (P = 0.043) and remained significant in a multivariable model. This study demonstrated that we obtained vancomycin trough levels in the target therapeutic range early during the course of therapy and that obtaining a higher vancomycin AUC/MIC (in this case, >373) within 96 h was associated with reduced mortality. The MIC test method has a significant impact on vancomycin AUC/MIC estimation. Clinicians should be aware that the current target AUC/MIC of ≥ 400 was derived using the reference BMD method, so adjustments to this target need to be made when calculating AUC/MIC ratio using other MIC testing methods.

Vancomycin AUC/MIC Ratio and 30-Day Mortality in Patients with Staphylococcus aureus Bacteremia

PubMed Central

Turnidge, John D.; Munckhof, Wendy J.; Robinson, J. Owen; Korman, Tony M.; O'Sullivan, Matthew V. N.; Anderson, Tara L.; Roberts, Sally A.; Warren, Sanchia J. C.; Gao, Wei; Howden, Benjamin P.; Johnson, Paul D. R.

2013-01-01

A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. aureus infections. Here, vancomycin serum trough levels and vancomycin AUC/MIC were evaluated in a “real-world” context by following a cohort of 182 patients with S. aureus bacteremia (SAB) and analyzing these parameters within the critical first 96 h of vancomycin therapy. The median vancomycin trough level at this time point was 19.5 mg/liter. There was a significant difference in vancomycin AUC/MIC when using broth microdilution (BMD) compared with Etest MIC (medians of 436.1 and 271.5, respectively; P < 0.001). Obtaining the recommended vancomycin target AUC/MIC of ≥400 using BMD was not associated with lower 30-day all-cause or attributable mortality from SAB (P = 0.132 and P = 0.273, respectively). However, an alternative vancomycin AUC/MIC of >373, derived using classification and regression tree analysis, was associated with reduced mortality (P = 0.043) and remained significant in a multivariable model. This study demonstrated that we obtained vancomycin trough levels in the target therapeutic range early during the course of therapy and that obtaining a higher vancomycin AUC/MIC (in this case, >373) within 96 h was associated with reduced mortality. The MIC test method has a significant impact on vancomycin AUC/MIC estimation. Clinicians should be aware that the current target AUC/MIC of ≥400 was derived using the reference BMD method, so adjustments to this target need to be made when calculating AUC/MIC ratio using other MIC testing methods. PMID:23335735

Sirolimus for epilepsy in children with tuberous sclerosis complex: A randomized controlled trial.

PubMed

Overwater, Iris E; Rietman, André B; Bindels-de Heus, Karen; Looman, Caspar W N; Rizopoulos, Dimitris; Sibindi, Tafadzwa M; Cherian, Perumpillichira J; Jansen, Floor E; Moll, Henriëtte A; Elgersma, Ype; de Wit, Marie-Claire Y

2016-09-06

To investigate whether mammalian target of rapamycin complex 1 (mTORC1) inhibitors could reduce seizure frequency in children with tuberous sclerosis complex (TSC). Due to slow inclusion rate, target inclusion of 30 children was not reached. Twenty-three children with TSC and intractable epilepsy (age 1.8-10.9 years) were randomly assigned (1:1) to open-label, add-on sirolimus treatment immediately or after 6 months. Sirolimus was titrated to trough levels of 5-10 ng/mL. Primary endpoint was seizure frequency change during the sixth month of sirolimus treatment. Intention-to-treat analysis showed sirolimus treatment resulted in 41% seizure frequency decrease (95% confidence interval [CI] -69% to +14%; p = 0.11) compared to the standard-care period. Per protocol analysis of 14 children who reached sirolimus target trough levels in the sixth sirolimus month showed a seizure frequency decrease of 61% (95% CI -86% to +6%; p = 0.06). Cognitive development did not change. All children had adverse events. Five children discontinued sirolimus prematurely. We describe a randomized controlled trial for a non-antiepileptic drug that directly targets a presumed causal mechanism of epileptogenesis in a genetic disorder. Although seizure frequency decreased, especially in children reaching target trough levels, we could not show a significant benefit. Larger trials or meta-analyses are needed to investigate if patients with TSC with seizures benefit from mTORC1 inhibition. This trial was registered at trialregister.nl (NTR3178) and supported by the Dutch Epilepsy Foundation. This study provides Class III evidence that sirolimus does not significantly reduce seizure frequency in children with TSC and intractable epilepsy. The study lacked the precision to exclude a benefit from sirolimus. © 2016 American Academy of Neurology.

A biomarker record of temperature and phytoplankton community in Okinawa Trough since the last glacial maximum

NASA Astrophysics Data System (ADS)

Ruan, Jiaping

2017-04-01

A variety of biomarkers were examined from Ocean Drilling Program (ODP) core 1202B to reconstruct temperature and phytoplankton community structures in the southern Okinawa Trough for the past ca. 20000 years. Two molecular temperature proxies (Uk37 and TEX86) show 5-6 ℃ warming during the glacial/interglacial transition. Prior to the Holocene, the Uk37-derived temperature was generally 1-4 ℃ higher than TEX86-derived temperature. This difference, however, was reduced to <1 ℃ in the Holocene when the Kuroshio Current was intensified. Correspondingly, the phytoplankton biomarkers (e.g., C37:2 alkenone, brassicasterol, C30 1,15-diols and dinosterol) suggest a shift of planktonic community assemblages with coccolithophorids becoming more abundant in the Holocene at the expense of diatoms/dinoflagellates. Such a shift is related to the variability of nutrient, temperature and salinity in the Okinawa Trough, controlled by the sea level and the intensity of Kuroshio Current. The phytoplankton community change may have profound implications on atmospheric CO2 fluctuations during glacial/interglacial cycles since diatoms and dinoflagellates have a higher efficiency of biological pump than coccolithophorids.

Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation.

PubMed

Ueshima, Satoshi; Hira, Daiki; Fujii, Ryo; Kimura, Yuuma; Tomitsuka, Chiho; Yamane, Takuya; Tabuchi, Yohei; Ozawa, Tomoya; Itoh, Hideki; Horie, Minoru; Terada, Tomohiro; Katsura, Toshiya

2017-09-01

During anticoagulant therapy, major bleeding is one of the most severe adverse effects. This study aimed to evaluate the relationships between ABCB1, ABCG2, and CYP3A5 polymorphisms and plasma trough concentrations of apixaban, a direct inhibitor of coagulation factor X. A total of 70 plasma concentrations of apixaban from 44 Japanese patients with atrial fibrillation were analyzed. In these analyses, the plasma trough concentration/dose (C/D) ratio of apixaban was used as a pharmacokinetic index and all data were stratified according to the presence of ABCB1 (ABCB1 1236C>T, 2677G>T/A, and 3435C>T), ABCG2 (ABCG2 421C>A), and CYP3A5 (CYP3A5*3) polymorphisms. Influences of various clinical laboratory parameters (age, serum creatinine, estimated glomerular filtration rate, aspartate amino transferase, and alanine amino transferase) on the plasma trough C/D ratio of apixaban were included in analyses. Although no ABCB1 polymorphisms affected the plasma trough C/D ratio of apixaban, the plasma trough C/D ratio of apixaban was significantly higher in patients with the ABCG2 421A/A genotype than in patients with the ABCG2 421C/C genotype (P<0.01). The plasma trough C/D ratio of apixaban in patients with CYP3A5*1/*3 or *3/*3 genotypes was also significantly higher than that in patients with the CYP3A5*1/*1 genotype (P<0.05). Furthermore, the plasma trough C/D ratio of apixaban decreased with increased estimated glomerular filtration rate. These results indicate that ABCG2 421A/A and CYP3A5*3 genotypes and renal function are considered potential factors affecting trough concentrations of apixaban.

Patchy intergalactic He II absorption in HE 2347-4342. II. The possible discovery of the epoch of He-reionization

NASA Astrophysics Data System (ADS)

Reimers, D.; Kohler, S.; Wisotzki, L.; Groote, D.; Rodriguez-Pascual, P.; Wamsteker, W.

1997-11-01

We report on observations of redshifted Heii303.8 Angstroms absorption in the high-redshift QSO HE2347-4342 (z=2.885, V=16.1) with the Goddard High Resolution Spectrograph on board HST in its low resolution mode (bigtriangleup lambda = 0.7 Angstroms). With f_λ=3.6\\ 10(-15) ergcm(-2) s(-1) Angstroms(-1) at the expected position of Heii304 Angstroms absorption it is the most UV-bright high redshift QSO discovered so far. We show that the Heii opacity as a function of redshift is patchy showing spectral regions with low Heii opacity (``voids'') and regions with high Heii opacity (blacked-out ``troughs'') and no detectable flux. Combination with high-resolution optical spectra of the Lyalpha forest using CASPEC at the 3.6m telescope shows that the voids can be explained either exclusively by Lyalpha forest cloud absorption with a moderate N_{subs {He{sc ii}}}/N_{subs {H{sc i}}} ratio eta <=100 and turbulent line broadening or by a combination of Lyalpha forest with eta = 45 and thermal broadening plus a diffuse medium with tau_ {subs {GP}}({subs {He{sc ) ii}}} ~ 0.3. Since the latter is a minimum assumption for the Lyalpha forest, a strict upper limit to a diffuse medium is Omega_ {subs {diff}}<0.02 h50(-1.5) at z=2.8. In the troughs in addition to the Lyalpha forest opacity a continuous Heii 304 Angstroms opacity tau = 4.8(+infty }_{-2) is required. In case of photoionization, the troughs would require a diffuse component with a density close to Omega =~ 0.077(eta /45)(-0.5) h50(-1.5) , i.e. all baryons in the universe, which is inconsistent, however, with the observed absence of such a component in the voids. A tentative interpretation is that we observe the epoch of partial Heii reionization of the universe with patches not yet reionized. In that case a diffuse component with Omega_ {subs {diff}}>= 1.3\\ 10(-4) h(-1}_{50) would be sufficient to explain the ``trough'' opacity. The size of the 1163--1172 Angstroms trough is ~ 6 h50(-1) Mpc or ~ 2300 kms(-1) , respectively. We also discuss partially resolved Heii absorption of a high-ionization associated absorption system. Despite its high luminosity HE2347-4342 does not show a Heii proximity effect. A possible reason is that the strong associated system shields the Heii ionizing continuum. Based on observations collected at the European Southern Observatory, La Silla, Chile (ESO No.\\ 58.B--0116). Based on IUE observations collected at the ESA VILSPA ground station near Madrid, Spain. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by Aura, Inc., under NASA contract NAS 5--26\\,555.

A digital map of the high center (HC) and low center (LC) polygon boundaries delineated from high resolution LiDAR data for Barrow, Alaska

DOE Data Explorer

Gangodagamage, Chandana; Wullschleger, Stan

2014-07-03

This dataset represent a map of the high center (HC) and low center (LC) polygon boundaries delineated from high resolution LiDAR data for the arctic coastal plain at Barrow, Alaska. The polygon troughs are considered as the surface expression of the ice-wedges. The troughs are in lower elevations than the interior polygon. The trough widths were initially identified from LiDAR data, and the boundary between two polygons assumed to be located along the lowest elevations on trough widths between them.

Influence of V-N Microalloying on the High-Temperature Mechanical Behavior and Net Crack Defect of High Strength Weathering Steel

NASA Astrophysics Data System (ADS)

Qing, Jiasheng; Wang, Lei; Dou, Kun; Wang, Bao; Liu, Qing

2016-06-01

The influence of V-N microalloying on the high-temperature mechanical behavior of high strength weathering steel is discussed through thermomechanical simulation experiment. The difference of tensile strength caused by variation of [%V][%N] appears after proeutectoid phase change, and the higher level of [%V][%N] is, the stronger the tensile strength tends to be. The ductility trough apparently becomes deeper and wider with the increase of [%V][%N]. When the level of [%V][%N] reaches to 1.7 × 10-3, high strength weathering steel shows almost similar reduction of area to 0.03% Nb-containing steel in the temperature range of 800-900°, however, the ductility trough at the low-temperature stage is wider than that of Nb-containing steel. Moreover, the net crack defect of bloom is optimized through the stable control of N content in low range under the precondition of high strength weathering steel with sufficient strength.

Sedimentation and tectonics of the Sylhet trough, Bangladesh

USGS Publications Warehouse

Johnson, S.Y.; Nur Alam, A.M.

1991-01-01

The Sylhet trough, a sub-basin of the Bengal Basin in northeastern Bangladesh, contains a thick fill (12 to 16 km) of late Mesozoic and Cenozoic strata that record its tectonic evolution. Stratigraphic, sedimentologic, and petrographic data collected from outcrops, cores, well logs, and seismic lines are used to reconstruct the history of this trough. -from Authors

Numerical Optimization Using Desktop Computers

DTIC Science & Technology

1980-09-11

concentrating compound parabolic trough solar collector . Thermophysical, geophysical, optical and economic analyses were used to compute a life-cycle...third computer program, NISCO, was developed to model a nonimaging concentrating compound parabolic trough solar collector using thermophysical...concentrating compound parabolic trough Solar Collector . C. OBJECTIVE The objective of this thesis was to develop a system of interactive programs for the Hewlett

Concentrating Solar Power Projects - Yumen 50MW Thermal Oil Trough CSP

Science.gov Websites

project | Concentrating Solar Power | NREL Thermal Oil Trough CSP project Status Date : September 28, 2016 Project Overview Project Name: Yumen 50MW Thermal Oil Trough CSP project Country: China : Thermal Oil Power Block Turbine Capacity (Gross): 50.0 MW Turbine Capacity (Net): 50.0 MW Output Type

A mesoscale vortex over Halley Station, Antarctica

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, J.; Lachlan-Cope, T.A.; Warren, D.E.

1993-05-01

A detailed analysis of the evolution and structure of a mesoscale vortex and associated cloud comma that developed at the eastern edge of the Weddell Sea, Antarctica, during the early part of January 1986 is presented. The system remained quasi-stationary for over three days close to the British research station Halley (75[degrees]36'S, 26'42[degrees]W) and gave severe weather with gale-force winds and prolonged snow. The formation and development of the system were investigated using conventional surface and upper-air meteorological observations taken at Halley, analyses from the U.K. Meteorological Office 15-level model, and satellite imagery and sounder data from the TIROS-N-NOAA seriesmore » of polar orbiting satellites. The thermal structure of the vortex was examined using atmospheric profiles derived from radiance measurements from the TIROS Operational Vertical Sounder. Details of the wind field were examined using cloud motion vectors derived from a sequence of Advanced Very High Resolution Radiometer images. The vortex developed inland of the Brunt Ice Shelf in a strong baroclinic zone separating warm air, which had been advected polewards down the eastern Weddell Sea, and cold air descending from the Antarctic Plateau. The system intensified when cold, continental air associated with an upper-level short-wave trough was advected into the vortex. A frontal cloud band developed when slantwise ascent of warm air took place at the leading edge of the cold-air outbreak. Most of the precipitation associated with the low occurred on this cloud band. The small sea surface-atmospheric temperature differences gave only limited heat fluxes and there was no indication of deep convection associated with the system. The vortex was driven by baroclinic forcing and had some features in common with the baroclinic type of polar lows that occur in the Northern Hemisphere. 25 refs., 14 figs.« less

Structural evolution and tectonic style of the Tunisian central Atlas; role of inherited faults in compressive tectonics (Ghoualguia anticline)

NASA Astrophysics Data System (ADS)

Briki, Haithem; Ahmadi, Riadh; Smida, Rabiaa; Rekhiss, Farhat

2018-04-01

Geological mapping, field cross sections, structural analyses and new subsurface data were used to characterize the geometry and tectonic setting of the Ghoualguia structure, which is an E-W-trending anticline located between the Kalaa Khasba and Rouhia troughs of the central Tunisian Atlas. The results show an important NE-SW extensional phase during the Mesozoic, as demonstrated by synsedimentary normal faults (NW-SE and E-W) and thickness variations. In the Aouled Mdoua area, the absence of Paleocene-Eocene rocks indicates that the eastern and western parts of the Ghoualguia structure were separated by high topography. In addition, the angular unconformity observed between the Upper Cretaceous unit (Abiod Fm.) and the upper Eocene series (Souar Fm.) provide evidence of a tilted-block structure delineated by North-South faults. A major compressional phase during the middle to late Miocene created various detachment levels that originated mainly in the Triassic and Cretaceous deposits. Faults were reactivated as thrust and strike-slip faults, creating fault-related fold structures. In the core of the Ghoualguia fold, an original S-dipping normal fault underwent reverse movement as a back thrust. Fault-slip data indicate that the area records a major NE-SW extensional phase that took place during the late Miocene and Pliocene. A balanced cross section provides insight into the existence of two main detachment levels rooted in the Triassic (depth ± 6 km) and the lower Cretaceous (depth ± 2.5 km). The balanced cross section highlights a shortening of about 2.5 km along cross section and 1.5 km in the central part of the Ghoualguia anticline. This work underlines the predominant role of the inherited Mesozoic structures during the evolution of the Atlassic range and their influence on the geometry of the central Tunisian atlas.

Morphological evolution of Jinshan Trough in Hangzhou Bay (China) from 1960 to 2011

NASA Astrophysics Data System (ADS)

Liu, Yifei; Xia, Xiaoming; Chen, Shenliang; Jia, Jianjun; Cai, Tinglu

2017-11-01

An extensive system of tidal channels, starting with Jinshan Trough in the east, is located along the north shore of Hangzhou Bay, China. This contribution investigates the morphological evolution of Jinshan Trough by using 17 bathymetric charts from a series covering a period of 51 years from 1960 to 2011. Three stages of evolution during this period are distinguishable based on the morphology and annual mean volume data. The first stage (1960-1987) is characterized by extension of the trough; the second stage (1987-1996) is a relatively stable period with some adjustments in the trough morphology; the third stage (1996-2011) is marked by the processes of erosion and deposition in the beginning of the period and a subsequent slow erosion process. Spatio-temporal variability of the trough was evaluated by using empirical orthogonal function (EOF) analysis. The first eigenfunction indicates that erosion is the main evolution process and there exists three stages similar to those distinguished from volume variations. The second eigenfunction mainly reflects erosion and deposition in the northwest part of the trough located in the flood tidal current shadow area of the artificial headland in Jinshan. The third eigenfunction mainly reflects annual fluctuations of erosion and deposition in the side slope at the artificial headland in Jinshan. A particularly intense erosion process occurred between 1996 and 1998. The major effects on morphological evolution in Jinshan Trough from 1960 to 2011 were investigated and tentative conclusions were presented. Continuous coastal reclamations in Jinshan had the most pronounced effect on the morphological evolution during the first and the second stages. The storm surge had a pronounced effect on the evolution at the beginning of the third stage.

Design, revision, and application of ground-water flow models for simulation of selected water-management scenarios in the coastal area of Georgia and adjacent parts of South Carolina and Florida

USGS Publications Warehouse

Clarke, John S.; Krause, Richard E.

2000-01-01

Ground-water flow models of the Floridan aquifer system in the coastal area of Georgia and adjacent parts of South Carolina and Florida, were revised and updated to ensure consistency among the various models used, and to facilitate evaluation of the effects of pumping on the ground-water level near areas of saltwater contamination. The revised models, developed as part of regional and areal assessments of ground-water resources in coastal Georgia, are--the Regional Aquifer-System Analysis (RASA) model, the Glynn County area (Glynn) model, and the Savannah area (Savannah) model. Changes were made to hydraulic-property arrays of the RASA and Glynn models to ensure consistency among all of the models; results of theses changes are evidenced in revised water budgets and calibration statistics. Following revision, the three models were used to simulate 32 scenarios of hypothetical changes in pumpage that ranged from about 82 million gallons per day (Mgal/d) lower to about 438 Mgal/d higher, than the May 1985 pumping rate of 308 Mgal/d. The scenarios were developed by the Georgia Department of Natural Resources, Environmental Protection Division and the Chatham County-Savannah Metropolitan Planning Commission to evaluate water-management alternatives in coastal Georgia. Maps showing simulated ground-water-level decline and diagrams presenting changes in simulated flow rates are presented for each scenario. Scenarios were grouped on the basis of pumping location--entire 24-county area, central subarea, Glynn-Wayne-Camden County subarea, and Savannah-Hilton Head Island subarea. For those scenarios that simulated decreased pumpage, the water level at both Brunswick and Hilton Head Island rose, decreasing the hydraulic gradient and reducing the potential for saltwater contamination. Conversely, in response to scenarios of increased pumpage, the water level at both locations declined, increasing the hydraulic gradient and increasing the potential for saltwater contamination. Pumpage effects on ground-water levels and related saltwater contamination at Brunswick and Hilton Head Island generally diminish with increased distance from these areas. Additional development of the Upper Floridan aquifer may be possible in parts of the coastal area without affecting saltwater contamination at Brunswick or Hilton Head Island, due to the presence of two hydrologic boundaries--the Gulf Trough, separating the northern and central subareas; and the hypothesized Satilla Line, separating the central and southern subareas. These boundaries diminish pumpage effects across them; and may enable greater ground-water withdrawal in areas north of the Gulf Trough and south of the Satilla Line without producing appreciable drawdown at Brunswick or Hilton Head Island.

Martian Polar Caps: Folding, Faulting, Flowing Glaciers of Multiple Interbedded Ices

NASA Astrophysics Data System (ADS)

Kargel, J. S.

2001-12-01

The Martian south polar cap (permanent CO2 cap and polar layered deposits), exhibit abundant, varied, and widespread deformational phenomena. Folding and boudinage are very common. Strike-slip or normal faults are rarer. Common in the vicinity of major troughs and scarps are signs of convergent flow tectonics manifested as wrinkle-ridge-like surface folds, thrust faults, and viscous forebulges with thin-skinned extensional crevasses and wrinkle-ridge folds. Such flow convergence is predicted by theory. Boudinage and folding at the 300-m wavelength scale, indicating rheologically contrasting materials, is widely exposed at deep levels along erosional scarps. Independent morphologic evidence indicates south polar materials of contrasting volatility. Hence, the south polar cap appears to be a multiphase structure of interbedded ices. The north polar cap locally also exhibits flow indicators, though they are neither as common nor as varied as in the south. The large-scale quasi-spiral structure of the polar caps could be a manifestation of large-scale boudinage. According to this scenario, deep-level boudinage continuously originates under the glacial divide (the polar cap summit). Rod-like boudin structures are oriented transverse to flow and migrate outward with the large-scale flow field. Troughs develop over areas between major boudins. A dynamic competition, and possibly a rough balance, develops between the local flow field in the vicinity of a trough (which tends to close the trough by lateral closure and upwelling flow) and sublimation erosion (which tends to widen and deepen them). Over time, the troughs flow to the margins of the polar cap where they, along with other polar structures, are destroyed by sublimation. Major ice types contributing to rheological and volatility layering may include, in order of highest to lowest mechanical strength, CO2 clathrate hydrate, water ice containing inert/insoluble dust, pure water ice, water ice containing traces of liquid-soluble salts, water ice containing traces of solid-soluble acids, CO2 ice. This is also nearly the same sequence of highest to lowest melting/dissociation points, but it is different than the sequence of volatility. This geologic-structural interpretation and specific chemical models are amenable to testing by computational means and point the way toward future needed observations, including complete high-resolution imaging of the polar caps, measurement of flow fields (possibly by laser interferometry), mapping of subsurface structures (by radar and/or seismic methods), and determination of composition (by penetrators, drillers, or borers). New lab data are needed on the physical properties of candidate ices.

Effects of Combination Therapy With Immunomodulators on Trough Levels and Antibodies Against Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Disease: A Meta-analysis.

PubMed

Qiu, Yun; Mao, Ren; Chen, Bai-Li; Zhang, Sheng-Hong; Guo, Jing; He, Yao; Zeng, Zhi-Rong; Ben-Horin, Shomron; Chen, Min-Hu

2017-09-01

It is not clear whether combination therapy with immunomodulators affects the immunogenicity of tumor necrosis factor (TNF) antagonists in patients with inflammatory bowel disease. We performed a meta-analysis to quantify the effects of combined immunomodulator therapy on the presence of antibodies against TNF antagonists (antidrug antibodies [ADAs]) and trough levels of anti-TNF agents. We systematically searched publication databases for studies that reported prevalence of ADAs in patients who received anti-TNF agents. Raw data from studies that met the inclusion criteria were pooled to determine effect estimates. We performed subgroup and metaregression analyses to determine the level of heterogeneity among study outcomes. We analyzed findings from 35 studies that met inclusion criteria (results reported from 6790 patients with inflammatory bowel disease). The pooled risk ratio for formation of ADAs in patients receiving combined therapy with immunomodulators, versus that of patients receiving anti-TNF monotherapy, was 0.49 (95% confidence interval, 0.41-0.59; P < .001). However, the pooled analysis did not demonstrate a significant difference in trough levels of anti-TNF agents between patients with versus without concurrent use of immunomodulators (standardized mean difference, 0.11; 95% confidence interval, 0.19-0.41; P = .47). Subgroup analyses of patients treated with different TNF antagonists revealed no difference in the formation of ADAs (P = .50 for interaction); the protective effect of immunomodulators did not differ with type of drug patients were given (methotrexate vs thiopurines), or assay for ADA. We observed heterogeneity only among studies of patients with ulcerative colitis (I 2  = 76%). Funnel plot and Egger test analyses indicated publication bias in the studies (P = .001). In a meta-analysis of published studies, we associated combined treatment with immunomodulators with reduced risk of formation of antibodies against TNF antagonists in patients with inflammatory bowel disease. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

Cost-effectiveness analysis of pharmacokinetic-driven prophylaxis vs. standard prophylaxis in patients with severe haemophilia A.

PubMed

Iannazzo, Sergio; Cortesi, Paolo A; Crea, Roberto; Steinitz, Katharina; Mantovani, Lorenzo G; Gringeri, Alessandro

2017-09-01

: The objective of this study was to assess the cost-effectiveness of pharmacokinetic-driven prophylaxis in severe haemophilia A patients. A microsimulation model was developed to evaluate the cost-effectiveness of pharmacokinetic-driven prophylaxis vs. standard prophylaxis and estimate cost, annual joint bleed rate (AJBR), and incremental cost-effectiveness ratio over a 1-year time horizon for a hypothetical population of 10 000 severe haemophilia A patients. A dose of 30 IU/kg per 48 h was assumed for standard prophylaxis. Pharmacokinetic prophylaxis was individually adjusted to maintain trough levels at least 1 and 5 IU/dl or less. AJBR was estimated on the relationship between factor VIII (FVIII) levels and bleeding rate reported in the literature. Sensitivity analyses were performed to assess the stability of the model and the reliability of results. The FVIII dose was reduced in the 27.8% of patients with a trough level more than 5 IU/dl on standard prophylaxis, with a negligible impact on AJBR (+0.1 bleed/year). The FVIII dose was increased in the 10.6% of patients with trough levels less than 1 IU/dl on standard prophylaxis, with a significant reduction of AJBR (-1.9 bleeds/year). On average, overall, pharmacokinetic-driven prophylaxis was shown to decrease the AJBR from 1.012 to 0.845 with a slight reduction of the infusion dose of 0.36 IU/kg, with total saving of 5 197&OV0556; per patient-year. Pharmacokinetic-driven prophylaxis was preferable (i.e. more effective and less costly) compared with standard prophylaxis, with savings of 31 205&OV0556; per bleed avoided. Pharmacokinetic-driven prophylaxis, accounting for patients' individual pharmacokinetic variability, appears to be a promising strategy to improve outcomes with efficient use of available resources in severe haemophilia A patients.

Magnetic anomaly map of the central Cayman Trough, northwestern Caribbean Sea

USGS Publications Warehouse

Dillon, William P.; Edgar, N. Terence; Parson, Lindsay M.; Scanlon, Kathryn M.; Driscoll, George R.; Jacobs, Colin L.

1993-01-01

This is the first large-scale published map of magnetic anomalies in the central Cayman Trough area. Two previously published very small scale maps based on much less data are a regional map (Gough and Heirtzler, 1969) and a map compiled from several tracklines running parallel to the axis of the Cayman Trough (MacDonald and Holcombe, 1978).

Effect of Channel Catfish Ictalurus Punctatus Egg Mass Loading Rate on Performance of the “See-Saw” Incubator

USDA-ARS?s Scientific Manuscript database

The “See-Saw” is a vertical-lift incubator that increases water circulation around and through channel catfish egg masses. Baskets in the incubator move up and down on racks in conventional hatchery troughs, raising the rack in one trough while lowering the rack in the adjacent trough. Egg masses ...

Sirolimus Pharmacokinetics in Early Postmyeloablative Pediatric Blood and Marrow Transplantation

PubMed Central

Goyal, Rakesh K.; Han, Kelong; Wall, Donna A.; Pulsipher, Michael A.; Bunin, Nancy; Grupp, Stephan A.; Mada, Sripal R.; Venkataramanan, Raman

2014-01-01

This study examined the pharmacokinetics of sirolimus in pediatric allogeneic blood and marrow transplantation (BMT) recipients in the presence and absence of concomitant fluconazole. Forty pediatric BMT recipients received a daily oral dose of sirolimus and a continuous i.v. infusion of tacrolimus for graft-versus-host disease prophylaxis. Fluconazole was administered i.v. to 19 patients and orally to 6 patients. Full pharmacokinetic profiles of sirolimus within a single dosing interval were collected. Whole-blood sirolimus concentrations were measured by HPLC/mass spectrometry. Noncompartmental analysis was performed using WinNonlin. Nonlinear mixed-effects pharmacokinetic models were developed using NONMEM following standard procedures. The mean ± SD sirolimus trough level before the dose (C0) was 8.0 ± 4.6 ng/mL (range, 1.8–21.6 ng/mL). The peak concentration was 19.9 ± 11.8 ng/mL (range, 3.9–46.1 ng/mL), and the trough level 24 hours later (C24) was 9.1 ± 5.3 ng/mL (range, 1.0–19.1 ng/mL). The terminal disposition half-life (T1/2) was 24.5 ± 11.2 hours (range, 5.8–53.2 hours), and the area under the concentration-versus-time curve (AUC0–24) was 401.1 ± 316.3 ng·h/mL (range, 20.7–1332.3 ng·h/mL). In patients at steady state, C0 and C24 were closely correlated (R2 = 0.77) with a slope of 0.99, indicating the achievement of steady state. C24 was 1.7-fold greater (P = .036) and AUC0–24 was 2-fold greater (P = .012) in Caucasian patients (n = 22) compared with Hispanic patients (n = 9). The average apparent oral clearance was 3-fold greater (P = .001) and the apparent oral volume of distribution was 2-fold greater (P = .018) in patients age ≤12 years compared with those age >12 years. C24 was significantly lower in patients (n = 10) who developed grade III–IV aGVHD (n = 10) than in those with grade 0-II aGVHD (n = 22) (6.1 ± 2.9 ng/mL versus 9.4 ± 5.5 ng/mL; P = .044). Dose-normalized sirolimus trough concentrations were significantly higher in patients receiving concomitant fluconazole therapy compared with those not receiving fluconazole (C0: 3.9 ± 2.5 versus 2.4 ± 1.5 ng/mL/mg, P = .030; C24: 4.8 ± 3.3 versus 2.5 ± 1.7 ng/mL/mg, P = .018). This pharmacokinetic study of sirolimus in pediatric patients documents a large interindividual variability in the exposure of sirolimus. Steady-state trough blood concentrations were correlated with drug exposure. Trough concentrations were higher with a concomitant use of fluconazole and were higher in Caucasian patients than in Hispanic patients. Oral clearance was greater in children age ≤12 years than in older children and adolescents. With therapeutic drug monitoring, the majority (79%) of sirolimus trough levels could be maintained within the target range (3–12 ng/mL). This study provides a rationale and support for dose adjustments of sirolimus based on steady-state blood concentrations aimed at achieving a target concentration to minimize toxicity and maximize therapeutic benefits in pediatric BMT recipients. PMID:23266742

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turchi, Craig; Kurup, Parthiv; Akar, Sertac

This study lists material composition data for two concentrating solar power (CSP) plant designs: a molten-salt power tower and a hypothetical parabolic trough plant, both of which employ a molten salt for the heat transfer fluid (HTF) and thermal storage media. The two designs have equivalent generating and thermal energy storage capacities. The material content of the saltHTF trough plant was approximately 25% lower than a comparably sized conventional oil-HTF parabolic trough plant. The significant reduction in oil, salt, metal, and insulation mass by switching to a salt-HTF design is expected to reduce the capital cost and LCOE for themore » parabolic trough system.« less

Cut By Troughs

NASA Technical Reports Server (NTRS)

2005-01-01

1 September 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows an impact crater cut by troughs which formed after the crater formed. The crater and troughs have large windblown ripples on their floors. The ripples, troughs, craters, and other surfaces in this scene have all been mantled by dust. Dark streaks on slopes indicate areas where avalanches of dry dust have occurred. These features are located on Sacra Mena, a large mesa in the Kasei Valles region.

Location near: 25.4oN, 66.8oW Image width: width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Autumn

Aeolian Sediment Transport Pathways and Aerodynamics at Troughs on Mars

NASA Technical Reports Server (NTRS)

Bourke, Mary C.; Bullard, Joanna E.; Barnouin-Jha, Olivier S.

2004-01-01

Interaction between wind regimes and topography can give rise to complex suites of aeolian landforms. This paper considers aeolian sediment associated wit11 troughs on Mars and identifies a wider range of deposit types than has previously been documented. These include wind streaks, falling dunes, "lateral" dunes, barchan dunes, linear dunes, transverse ridges, sand ramps, climbing dunes, sand streamers, and sand patches. The sediment incorporated into these deposits is supplied by wind streaks and ambient Planitia sources as well as originating within the trough itself, notably from the trough walls and floor. There is also transmission of sediment between dneTsh. e flow dynamics which account for the distribution of aeolian sediment have been modeled using two-dimensional computational fluid dynamics. The model predicts flow separation on the upwind side of the trough followed by reattachment and acceleration at the downwind margin. The inferred patterns of sediment transport compare well with the distribution of aeolian forms. Model data indicate an increase of wind velocity by approx. 30 % at the downwind trough margin. This suggests that the threshold wind speed necessary for sand mobilization on Mars will be more freqentmlye t in these inclined locations.

Studies of plasma irregularities and convection in the polar ionosphere using HILAT, SABRE and EISCAT. Interim report, 1 Feb 88-31 Mar 89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, T.B.; Lester, M.; Wilkinson, A.J.

A statistical study of the F-region main ionospheric trough has been undertaken with EISCAT common programme data to assess the possibility that the trough region is a perferential region for the generation of E-region irregularities. Three years of CP-3 data from EISCAT formed the basis of this study. Backscatter observed by the coherent radar, SABRE, was also utilized to study the occurrence of irregularities in the E-region. On 26 out of the 36 days when the trough was observed by EISCAT, SABRE observed coherent backscatter. Although this percentage seems high, there was no consistent relationship between the latitude of themore » trough minimum and the latitude of peak backscatter intensity. A case study involving a four day run of EISCAT in September 1986 indicates that the trough latitude can be affected by changes in the interplanetary magnetic field north-south components. On two days rapid decreases in the latitude of the trough were related to a southward turning of the IMF and the onset of backscatter. The high percentage of occurrence of backscatter is believed to be caused by enhanced convection.« less

Fast flow of Jakobshavn Isbræ and its subglacial drainage system

NASA Astrophysics Data System (ADS)

Werder, M. A.; Joughin, I. R.

2013-12-01

Jakobshavn Isbræ and many other outlet glaciers of present and past ice sheets lie in deep troughs which often have several overdeepened sections. The subglacial drainage system of such glaciers is heavily influenced by two effects caused by the pressure dependence of the melting point of water. The melting point decreases with increasing water pressure, this enhances wall-melt in downward sloping channels and diminishes wall-melt in upward sloping channels. Thus the first effect is the well known shutdown of channels on steep adverse bed slopes of overdeepenings and the associated high water pressure/low effective pressure. The second effect is a 2D effect and has not received much/any attention so far: the orientation of a channel will be deflected from the direction of the (negative) hydraulic potential gradient (which drives the water flow) towards the steepest slope of the bed. This leads to the enhanced formation of side channels dipping into the trough at about a 45° angle. This efficient connection between the margin and the trough equalizes the hydraulic potential, again leading to higher water pressure in the trough. We investigate these two effects with the 2D subglacial drainage system model GlaDS using Jakobshavn Isbræ as an example. We compare model runs with the pressure melt term disabled and enabled. With the term disabled the main channel situated in the trough is continuous and produces a large depression in the hydraulic potential and consequently high effective pressure in the trough (1-2MPa). Conversely, with the term enabled the main channel becomes discontinuous on steep adverse bed slopes and many side channels form on the margins of the trough. This leads to a hydraulic potential in the trough which is higher than in the surrounding area and consequently the effective pressure is low (0-1MPa). Low effective pressure leads to reduced basal drag and thus to more basal sliding. The modeled large decrease of effective pressure in the trough due to the pressure dependence of the melting point of water suggests that basal drag will be small and that sliding speeds are large. Thus, this may be one of the leading causes for the fast flow of Jakobshavn Isbræ and other glaciers in deep troughs.

Weak lensing by galaxy troughs in DES Science Verification data

DOE PAGES

Gruen, D.; Friedrich, O.; Amara, A.; ...

2015-11-29

In this study, we measure the weak lensing shear around galaxy troughs, i.e. the radial alignment of background galaxies relative to underdensities in projections of the foreground galaxy field over a wide range of redshift in Science Verification data from the Dark Energy Survey. Our detection of the shear signal is highly significant (10σ–15σ for the smallest angular scales) for troughs with the redshift range z ϵ [0.2, 0.5] of the projected galaxy field and angular diameters of 10 arcmin…1°. These measurements probe the connection between the galaxy, matter density, and convergence fields. By assuming galaxies are biased tracers ofmore » the matter density with Poissonian noise, we find agreement of our measurements with predictions in a fiducial Λ cold dark matter model. The prediction for the lensing signal on large trough scales is virtually independent of the details of the underlying model for the connection of galaxies and matter. Our comparison of the shear around troughs with that around cylinders with large galaxy counts is consistent with a symmetry between galaxy and matter over- and underdensities. In addition, we measure the two-point angular correlation of troughs with galaxies which, in contrast to the lensing signal, is sensitive to galaxy bias on all scales. The lensing signal of troughs and their clustering with galaxies is therefore a promising probe of the statistical properties of matter underdensities and their connection to the galaxy field.« less

The Nova-Canton Trough and the Late Cretaceous evolution of the central Pacific

NASA Astrophysics Data System (ADS)

Joseph, Devorah; Taylor, Brain; Shor, Alexander N.; Yamazaki, Toshitsugu

Free-air gravity anomalies derived from satellite altimetry data show that the major Pacific fracture zones, from the Pau to Marquesas, are co-polar about an Euler pole located at 150.5°W, 34.6°S for the period preceding chron 33 and including a large portion of the Cretaceous Normal Superchron. They also show continuity of the Clipperton Fracture Zone through the Line Islands to the Nova-Canton ridge and trough; this Canton-Clipperton trend is co-polar to the same pole. Sidescan-sonar and bathymetry data in the Nova-Canton Trough region reveal N140°E-striking abyssal hill topography south of the N70°E-striking structures of the Nova-Canton Trough and crustal fabric striking normal to the trough (N160°E) to the north. We conclude that the Nova-Canton Trough is the Middle Cretaceous extension of the Clipperton Fracture Zone. We propose that the anomalous depths (7000-8400 m) of the trough between 167°30'-168°30'W are the result of a complex plate reorganization. Conjugate magnetic anomaly lineations M1-M3 in the Phoenix lineations between the Central Pacific Fracture Zone and the Phoenix Fracture Zone and the absence of lineations younger than anomaly M3 west of the Phoenix Fracture Zone suggest that spreading may have gradually ceased along the Pacific-Phoenix system from west to east. We infer that the remaining active segment of the Pacific-Phoenix spreading system after anomaly M1 time was the easternmost section of the Phoenix lineations. At ˜M0 time, the Pacific-Phoenix spreading axis stretched from lineated bathymetric depressions lying between 180°W and the Phoenix Islands to ˜168°W and included the western deep of the Nova-Canton Trough. We hypothesize that accretion terminated on the Pacific-Phoenix spreading axis shortly after M0 time and that the absence of an M0 isochron in the region between the eastern Phoenix lineations and the Nova-Canton Trough, or along the Nova-Canton Trough itself, may be due to a decrease in spreading rate prior to termination. We concur with previous hypotheses that portions of the Phoenix plate were trapped on the Pacific plate by a ridge jump south to the nascent Manihiki Plateau; some portions were overprinted by the Aptian volcanism that formed the Manihiki Plateau and Robbie Ridge. Pacific-Farallon spreading south of the Nova-Canton Trough jumped westwards, initiating transcurrent motion along the easternmost section of the failed ˜M0 spreading axis (the western deep of the Nova-Canton Trough) which subsequently became the western end of the Clipperton (Pacific-Farallon) transform. In our reconstruction, the northeast and southeast margins of the Manihiki Plateau are rifted margins that form the western limit of Pacific-Farallon spreading between the Clipperton, Galapagos, and Marquesas fracture zones.

Outcrops In Aram Chaos

NASA Technical Reports Server (NTRS)

2004-01-01

16 October 2004 Aram Chaos is the name of an approximately 275 km (171 mi) diameter impact crater near Ares Vallis, roughly half way between the Mars Exploration Rover, Opportunity, site in Meridiani Planum and the easternmost troughs of the Valles Marineris. The Aram Chaos crater is partially filled with a thick accumulation of layered rock. Erosion has exposed light- and dark-toned rock materials in the basin. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a small area exhibiting some of the rock outcrops in Aram Chaos. The light-toned rocks may be sedimentary in origin. This image is located near 4.0oN, 20.6oW, and covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the upper left.

The MURAVES muon telescope: technology and expected performances

DOE PAGES

Saracino, Giulio; Ambrosino, Fabio; Bonechi, Lorenzo; ...

2016-01-01

Here, the MURAVES project aims to study the inner structure of the upper part of the Mt. Vesuvius volcano by muon radiography (muography) technique. Very high energy muons, produced by cosmic rays in the atmosphere, can penetrate large thickness of rocks. By measuring the attenuation of the muons flux trough the volcano cone is possible to obtain a 2D image of the density structure. Internal discontinuities, with a spatial resolution of about 10 m, can be, in principle, resolved. An absolute average density measurement can be provided too. The project, funded by the Italian Ministry of University, Research and Educationmore » (MIUR), is led by INGV and INFN. In this article the mechanical structure of the detectors and background suppression techniques are reported.« less

The Sharav Cyclone: Observations and some theoretical considerations

NASA Astrophysics Data System (ADS)

Alpert, P.; Ziv, B.

1989-12-01

A special study of the Sharav Cyclones indicates that they are the result of large-scale weak baroclinicity, enhanced by vigorous boundary-layer baroclinicity between the North African coast and the Mediterranean. It is illustrated how the jet stream plays a major role in the vertical circulation in producing a complex cyclonic circulation dominated by at least three mechanisms: large-scale interior baroclinicity, boundary-layer baroclinicity, and jet stream related circulations. The main characteristics of the Sharav Cyclone (also called the Saharan Depression or Khamsin Depression) in the Mediterranean are reviewed. Unlike the cold winter cyclone, the Sharav Cyclone is a spring cyclone. Its tracks lie mainly along the North African coast and turn to the north near the southeastern Mediterranean. Its warm front is active and is sometimes associated with extremely high surface temperatures. Its cold front is shallow. The Sharav Cyclone moves eastward relatively fast, typically faster than 10 m s-1, and with a small speed variability. In general, there is an upper level trough to the west of the surface low and the surface horizontal scale is of the order of 500-1000 km. Finally, it is frequently associated with heavy dust/sand storms and low visibilities. Some of these features are illustrated in a case study of the April 28-30, 1986, cyclone. Vertical cross sections indicate a deep circulation associated with the exit region of an upper level jet. In addition to presenting evidence that the Sharav Cyclone is a deep tropospheric circulation, it is shown that the transverse indirect circulation at the exit region of the jet is a major component of its circulation. The classic two-level baroclinic model (Phillips, 1954) is applied. The effects of the major diabatic heating due to the sensible heat flux above the North African desert and the large north to south temperature gradients are incorporated through the thermal wind of the basic state. The model predicts the fast eastward motion, the relatively smaller horizontal scale and the fast growth rate. Furthermore, the model predicts an annual maximum growth rate in April and a secondary peak in October, which agrees with the frequency of occurrences of the Sharav Cyclones.

Links Between the Madden-Julian Oscillation and Severe Convective Storms in the U.S.

NASA Astrophysics Data System (ADS)

Barrett, B.

2015-12-01

Recent research has shown a tendency for severe convective storms to vary intraseasonally, including by phase of the Madden-Julian Oscillation (MJO). The MJO is the leading mode of atmospheric intraseasonal variability and is characterized by large regions (1000-5000 km) of anomalous convective activity that generally propagate eastward along the equator. Anomalous upper-troposphere heating associated with this convection generates poleward-propagating Rossby waves that interact with the preexisting extratropical circulation. The projection of this interaction onto the synoptic scale - via the favoring of troughs and ridges at certain positions - is the hypothesized mechanism by which the MJO modulates severe convection. However, one unexplored aspect of this modulation is the extent to which severe convection in winter and early-spring months, especially Jan-Mar, may be influenced by different phases of the MJO. While climatologically rarer than events later in spring, severe thunderstorms in winter and early spring still have potential to be high-impact weather events, especially as they often occur in populated areas of the southeast U.S. that have shown more vulnerability than other regions such as the southern or central plains. Results from other studies (not necessarily focused on the question of severe convective storms) have indicated statistically significant modulation of upper- and mid-tropospheric circulation (from 200 hPa to 700 hPa), surface temperature, and sea level pressure. Thus, it is possible that the MJO's influence also extends to severe storms, as these are ingredients known to affect the likelihood of convective activity in the U.S. Using a methodology similar to other recent MJO studies, the impacts of the MJO on tornado, hail, and wind activity from Jan-Mar will be tested as part of this larger project to understand intraseasonal variability of severe storms.

Coral reef complexes at an atypical windward platform margin: Late Quaternary, southeast Florida

USGS Publications Warehouse

Lidz, B.H.

2004-01-01

Major coral reef complexes rim many modern and ancient carbonate platforms. Their role in margin evolution is not fully understood, particularly when they border a margin atypical of the classic model. Classic windward margins are steeply inclined. The windward margin of southeast Florida is distinct with a very low-gradient slope and a shelf edge ringed with 30-m-high Quaternary outlier reefs on a shallow upper-slope terrace. A newly developed synthesis of temporally well-constrained geologic events is used with surface and subsurface seismic-reflection contours to construct morphogenetic models of four discontinuous reef-complex sequences. The models show uneven subsurface topography, upward and landward buildups, and a previously unreported, rapid, Holocene progradation. The terms backstepped reef-complex margin, backfilled prograded margin, and coalesced reef-complex margin are proposed for sections exhibiting suitable signatures in the stratigraphic record. The models have significant implications for interpretation of ancient analogues. The Florida record chronicles four kinds of geologic events. (1) Thirteen transgressions high enough for marine deposition occurred between ca. 325 ka and the present. Six gave rise to stratigraphically successive coral reef complexes between ca. 185 and ca. 77.8 ka. The seventh reef ecosystem is Holocene. (2) Two primary coral reef architectures built the outer shelf and margin, producing respective ridge-and-swale and reef-and-trough geometries of very different scales. (3) Massive outlier reefs developed on an upper-slope terrace between ca. 106.5 and ca. 80 ka and are inferred to contain corals that would date to highstands at ca. 140 and 125 ka. (4) Sea level remained below elevation of the shelf between ca. 77.8 and ca. 9.6 ka. ?? 2004 Geological Society of America.

Mangala Fossa

NASA Technical Reports Server (NTRS)

2002-01-01

(Released 29 May 2002) The Science Today's THEMIS release captures Mangala Fossa. Mangala Fossa is a graben, which in geologic terminology translates into a long parallel to semi-parallel fracture or trough. Grabens are dropped or downthrown areas relative to the rocks on either side and these features are generally longer than they are wider. There are numerous dust devil trails seen in this image. In the lower portion of this image several dust devil tracks can be seen cutting across the upper surface then down the short stubby channel and finally back up and over to the adjacent upper surface. Some dust avalanche streaks on slopes are also visible. The rough material in the upper third of the image contains a portion of the rim of a 90 km diameter crater located in Daedalia Planum. The smooth crater floor has a graben (up to 7 km wide) and channel (2 km wide) incised into its surface. In the middle third and right of this image one can see ripples (possibly fossil dunes) on the crater floor material just above the graben. The floor of Mangala Fossa and the southern crater floor surface also have smaller linear ridges trending from the upper left to lower right. These linear ridges could be either erosional (yardangs) or depositional (dunes) landforms. The lower third of the scene contains a short stubby channel (near the right margin) and lava flow front (lower left). The floor of this channel is fairly smooth with some linear crevasses located along its course. One gets the impression that the channel floor is mantled with some type of indurated material that permits cracks to form in its surface. The Story In the Daedalia Plains on Mars, the rim of an old eroded crater rises up, a wreck of its former self (see context image at right). From the rough, choppy crater rim (top of the larger THEMIS image), the terrain descends to the almost smooth crater floor, gouged deeply by a trough, a channel, and the occasional dents of small, scattered craters. The deep trough running from southwest to northeast across the middle of this image is called 'Mangala Fossa.' Mangala Fossa is a graben, a land feature created by tectonic processes that worked to create a depression in the landscape. This graben is a little more than 4 miles wide at its maximum, but like most grabens, is much longer than it is wide. You can see from the context image that it runs across much of the width of the crater. Running southward from the graben (lower right-hand side of the larger THEMIS image) is a branching channel a little over a mile wide. The floor of this channel is fairly smooth with some linear crevasses along its course. These features suggest that the channel floor might be layered with some type of cemented material that permits cracks to form in its surface. Between the rough crater rim and the depressed graben, tiny crackles on the otherwise smooth surface appear. They might be the ripples of fossil dunes, hardened remains from a more active time. The floor of Mangala Fossa and the southern crater floor surface also feature small lines that seem to crease the surface. We know that they are ridges on the surface, but how did they form? Were higher surfaces carved away in grooves by the wind and scouring sand, forming ridges called yardangs? Or were dunes deposited on the smooth, lower terrain? No one knows for sure. Look closely for faint details as well. Do you see the subtle, scalloped pattern that laps at the lower left of the image, almost too muted to be seen? That's the sign of an ancient lava flow that stopped just there. And the shadowy gray streaks? Some are smudges caused by dust avalanches running down the slopes of the channel. Others are the tracks of dust devils that pass across the land, lifting and carrying away brighter dust to reveal the darker surface beneath. For a good example of a dust devil track, check out the faint gray line that cuts across the upper part of the channel, just below the point where it meets the graben.

Seismic stratigraphy of sedimentary cover in Amerasian Basin based on the results of Russian High Arctic expeditions

NASA Astrophysics Data System (ADS)

Poselov, Viktor; Kireev, Artem; Smirnov, Oleg; Butsenko, Viktor; Zholondz, Sergey; Savin, Vasily

2016-04-01

Massive amount of multichannel seismic (MCS) data were obtained by Russian High Arct ic expeditions "Arctica-2011", "Acrtica-2012" and "Arctica-2014". More than 40 MCS lines are located in the Amerasian basin and help to substantiate the seismic stratigraphy model of its sedimentary cover. The proposed seismic stratigraphy model was successively determined for the Cenozoic and pre-Cenozoic parts of the sedimentary section and was based on correlation of the Russian MCS data and seismic data documented by boreholes. Cenozoic part of the sedimentary cover is based on correlation of the Russian MCS data and AWI91090 section calibrated by ACEX-2004 boreholes on the Lomonosov Ridge. Two major unconformities are traced. The upper regional unconformity (RU) is associated with a major pre-Miocene hiatus. Another major hiatus is recorded in the borehole section between the Campanian and the Upper Paleocene units. It is recognized as the post-Campanian unconformity (pCU) in the seismic sections. Formation of the regional unconformities is associated with a fundamental change in depositional environment. Formation of RU was initiated by opening of the Fram Strait gateway at the Paleogene/Neogene boundary. Post-Campanian unconformity is linked with the initial stage of the Eurasian Basin opening between the Cretaceous and the Paleogene. Cenozoic sedimentary units are continuously traced from the East-Siberian and Chukchi sea shelves across the transit zone to the Amerasian basin. Paleogene unit (between pCU and RU) is formed under the neritic depositional environment and it is characterized by an extremely small thickness on the Lomonosov Ridge (less than 200 m), on the Mendeleev Rise and in the Podvodnikov Basin (not more than 300-400 m). Neogene unit (above RU) consists of hemipelagic deposits and occupies the essential part of thickness of the Cenozoic section in Podvodnikov and Makarov Basins. Interval velocities in the Paleogene unit vary within 2.8-3.2 km/s, in the Neogene unit they vary within 1.8-2.7 km/s. Pre-Cenozoic part of the sedimentary cover is based on tracing major unconformities from boreholes on the Chukchi shelf (Crackerjack, Klondike, Popcorn) to the North-Chuckchi Trough and further to the Mendeleev Rise as well as to the Vilkitsky Trough and the adjacent Podvodnikov Basin. Three regional unconformities are correlated: Jurassic (JU - top of the Upper Ellesmerian unit), Lower Cretaceous (LCU) and Brookian (BU - base of the Lower Brookian unit). Above the acoustic basement the pre-Cenozoic section is mainly represented by terrigenous units. Two major unconformities: RU and pCU are allocated on all MCS lines intersecting the Mendeleev Rise along its entire extent. BU is traced nearly everywhere along the rise excepting certain acoustic basement highs. All unconformities are also traced from the Mendeleev Rise to the continental structure of the Chuckchi Borderland. Sedimentary sequence between pCU and JU which underlies deposits of the Upper Ellesmerian unit is recorded as a synrift unit of the entire area of the Podvodnikov Basin. MCS data show a natural prolongation of the sedimentary cover from the shelf to the Podvodnikov Basin without any breaks and tectonic movements. Interval velocities in the Upper Cretaceous unit (between pCU and BU) vary within 3.2-3.9 km/s, in the pre-Upper Cretaceous units (between BU and the acoustic basement) vary within 4.1-4.8 km/s.

Geology of the Volga-Ural petroleum province and detailed description of the Ramashkino and Arlan oil fields

USGS Publications Warehouse

Peterson, James A.; Clarke, James W.

1983-01-01

The Volga-Ural petroleum province is in general coincident with the Volga-Ural regional high, a broad upwarp of the east-central part of the Russian (East European) platform. The central part of the province is occupied by the Tatar arch, which contains the major share of the oil fields of the province. The Perm-Bashkir arch forms the northeastern part of the regional high, and the Zhigulevsko-Orenburg arch makes up the southern part. These arches are separated from one another by elongate downwarps. The platform cover overlies an Archean crystalline basement and consists of seven main sedimentation cycles as follows: 1) Riphean (lower Bavly) continental sandstone, shale, and conglomerate beds from 500 to 5,000 m thick deposited in aulacogens. 2) Vendian (upper Bavly) continental and marine shale and sandstone up to 3,000 m thick. 3) Middle Devonian-Tournaisian transgressive deposits, which are sandstone, siltstone, and shale in the lower part and carbonates with abundant reefs in the upper; thickness is 300-1,000 m. In the upper carbonate part is the Kamsko-Kinel trough system, which consists of narrow interconnected deep-water troughs. 4) The Visean-Namurian-Bashkirian cycle, which began with deposition of Visean clastics that draped over reefs of the previous cycle and filled in an erosional relief that had formed in some places on the sediments of the previous cycle. The Visean clastics are overlain by marine carbonates. Thickness of the cycle is 50-800 m. 5) Early Moscovian-Early Permian terrigenous clastic deposits and marine carbonate beds 1,000-3,000 m thick. 6) The late Early Permian-Late Permian cycle, which reflects maximum growth of the Ural Mountains and associated Ural foredeep. Evaporites were first deposited, then marine limestones and dolomites, which intertongue eastward with clastic sediments from the Ural Mountains. 7) Continental redbeds of Triassic age and mixed continental and marine elastic beds of Jurassic and Cretaceous age, which were deposited on the southern, southwestern, and northern margins of the Russian platform; they are generally absent in the Volga-Ural province, however. The Volga-Ural oil and gas basin is a single artesian system that contains seven aquifers separated by seals. The areas of greatest hydraulic head are in the eastern parts of the basin near areas where the aquifers crop out on the western slopes of the Ural Mountains. The Peri-Caspian basin is the principal drainage area of the artesian system. Approximately 600 oil and gas fields and 2,000 pools have been found in the Volga-Ural province. Nine productive sequences are recognized as follows: 1) Upper Proterozoic (Bavly beds), which are promising but not yet commercial. 2) Clastic Devonian, which contains the major reserves and includes the main pays of the super-giant Romashkino field. 3) Carbonate Upper Devonian and lowermost Carboniferous, which is one of the main reef-bearing intervals. 4) Visean (Lower Carboniferous) elastics, which are the main pays in the super-giant Arian field. 5) Carbonate Lower and Middle Carboniferous. 6) Clastic Middle Carboniferous Moscovian. 7) Carbonate Middle and Upper Carboniferous. 8) Carbonate-evaporite Lower Permian, which contains the major gas reserves and the lower part of the Melekess tar deposits. 9) Clastic-carbonate Upper Permian, which contains the major part of the Melekess tar deposits. The Volga-Ural province is divided into several productive regions on a basis of differences in structure, distribution of reservoir and source-rock facies, and general composition of the petroleum accumulations. These regions are the Tatar arch, Birsk saddle, Upper Kama depression, Perm-Bashkir arch, Ufa-Orenburg monocline, Melekess-Sernovodsko-Abdulino basin, Zhligulevsko-Orenburg arch, Ural foredeep, and north borders of the Peri-Casplan depression. Exploration activity has declined in recent years; however, interest remains high in several parts of the province, particula

The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study.

PubMed

Moots, Robert J; Xavier, Ricardo M; Mok, Chi Chiu; Rahman, Mahboob U; Tsai, Wen-Chan; Al-Maini, Mustafa H; Pavelka, Karel; Mahgoub, Ehab; Kotak, Sameer; Korth-Bradley, Joan; Pedersen, Ron; Mele, Linda; Shen, Qi; Vlahos, Bonnie

2017-01-01

To assess the incidence of anti-drug antibodies (ADA) in patients with rheumatoid arthritis (RA) treated with the TNF inhibitors etanercept (ETN), adalimumab (ADL), or infliximab (IFX), and determine the potential relationship with trough drug concentration, efficacy, and patient-reported outcomes. This multi-national, non-interventional, cross-sectional study (NCT01981473) enrolled adult patients with RA treated continuously for 6-24 months with ETN, ADL, or IFX. ADA and trough drug concentrations were measured by independent assays ≤2 days before the next scheduled dose. Efficacy measurements included Disease Activity Score 28-joint count (DAS28), low disease activity (LDA), remission, and erythrocyte sedimentation rate (ESR). Targeted medical histories of injection site/infusion reactions, serum sickness, and thromboembolic events were collected. Baseline demographics of the 595 patients (ETN: n = 200; ADL: n = 199; IFX: n = 196) were similar across groups. The mean duration of treatment was 14.6, 13.5, and 13.1 months for ETN, ADL, and IFX, respectively. All ETN-treated patients tested negative for ADA, whereas 31.2% and 17.4% patients treated with ADL and IFX, respectively, tested positive. In ADL- or IFX-treated patients, those with ADA had significantly lower trough drug concentrations. There were negative correlations between trough drug levels and both CRP and ESR in ADL- and IFX-treated patients. DAS28-ESR LDA and remission rates were higher in patients without ADA. The rate of targeted medical events reported was low. ADA were detected in ADL- and IFX-treated but not ETN-treated patients. Patients without ADA generally showed numerically better clinical outcomes than those with ADA. This study was registered on www.ClinicalTrials.gov (NCT01981473).

Ramp sedimentation in the Dinantian limestones of the Shannon Trough, Co. Limerick, Ireland

NASA Astrophysics Data System (ADS)

Somerville, Ian D.; Strogen, Peter

1992-08-01

During the late Chadian and Arundian (Lower Carboniferous), an extensive carbonate ramp (Limerick Ramp) developed over County Limerick, southwest Ireland, dipping northwestwards. Three distinct facies can be recognised corresponding to position on this ramp: inner, mid- and outer ramp. The inner ramp facies of oolitic and crinoidal grainstones (Herbertstown Limestone Formation) in east Limerick formed a major shoal behind which peritidal limestones were deposited. The mid-ramp facies of muddy bioclastic limestones and shales (Cooperhill facies) in north Limerick formed between fairweather and storm wave bases. The outer ramp (basinal) facies of mudstones and thin graded resedimented limestones (Rathkeale Beds) in west Limerick developed below storm wave base when fine terrigenous input was high. Later in the Arundian there was progradation of the nearshore oolitic and crinoidal grainstones over the mid-ramp facies. By the Holkerian, the deep-water basinal facies in west Limerick was buried beneath mid-ramp facies (Durnish Limestone). The initiation of the Limerick Ramp is closely related to the formation of the Shannon Trough. In the late Courceyan, accelerated subsidence in the Shannon area during deposition of Waulsortian facies marked the onset of a sag phase. Following a quiescent period in early Chadian, subsidence was renewed in the late Chadian and Arundian, when major facies changes occurred on the ramp. Comparison of the Shannon Trough with the Dublin Basin shows that in the latter, tectonic events in the Chadian and Arundian, particularly syn-sedimentary faulting, created a sharp division between platform and basinal sedimentation. Such tectonic influence is not recognised in the Shannon Trough. Here differential subsidence and eustatic sea-level changes led to more permanent ramp existence, modified only by westwards progradation.

Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China.

PubMed

Dong, Mo-Han; Wang, Jing-Wen; Wu, Yin; Chen, Bei-Yu; Yu, Min; Wen, Ai-Dong

2015-08-01

To identify specific risk factors of vancomycin-induced nephrotoxicity in China, as the relationship between vancomycin therapy (dosing and trough concentration monitoring) and nephrotoxicity has been the subject of critical debate. The cases of 90 critically ill patients who received vancomycin therapy in Xijing Hospital in the northwest of China between March 2014 and January 2015 were reviewed retrospectively. Vancomycin dosing, blood serum trough concentration, and other independent risk factors associated with nephrotoxicity were evaluated in a multivariable model. Among the 90 critically ill patients, 59 were males; mean age was 46.3 years. The indications for vancomycin use were methicillin-resistant Staphylococcus aureus-associated pneumonia, central nervous system infection, and bacteremia. Clinical pharmacists prescribed weight-based dosing, ranging from 20 to 45mg/kg/day. Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from a mean (standard deviation) of 90.0 (18.8) μmol/l to 133.8 (63.2) μmol/l (p = 0.015). It was found that those with a vancomycin dosage >38mg/kg/day (50.0% vs. 11.3%, p = 0.004) and a vancomycin serum trough concentration >20mg/l (57.1% vs. 12.0%, p = 0.01) were more likely to develop nephrotoxicity. The data from this study indicate that a vancomycin dosage >38mg/kg/day and a serum trough level >20mg/l are both independent factors associated with the development of nephrotoxicity, suggesting that renal function should be monitored closely during vancomycin treatment. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Inner-shelf circulation and sediment dynamics on a series of shoreface connected ridges offshore of Fire Island, NY

USGS Publications Warehouse

Warner, John C.; List, Jeffrey H.; Schwab, William C.; Voulgaris, George; Armstrong, Brandy N.; Marshall, N

2014-01-01

Locations along the inner-continental shelf offshore of Fire Island, NY, are characterized by a series of shoreface connected ridges (SFCRs). These sand ridges have approximate dimensions of 10 km in length, 3 km spacing, up to ~8 m ridge to trough relief, and are oriented obliquely at approximately 30 degrees clockwise from the coastline. Stability analysis from previous studies explains how sand ridges such as these could be formed and maintained by storm-driven flows directed alongshore with a key maintenance mechanism of offshore deflected flows over ridge crests and onshore in the troughs. We examine these processes both with a limited set of idealized numerical simulations and analysis of observational data. Model results confirm that along-shore flows over the SFCRs exhibit offshore veering of currents over the ridge crests and onshore-directed flows in the troughs, and demonstrate the opposite circulation pattern for a reverse wind. To further investigate these maintenance processes, oceanographic instruments were deployed at seven sites on the SFCRs offshore of Fire Island to measure water levels, ocean currents, waves, suspended-sediment concentrations, and bottom stresses from January to April 2012. Data analysis reveals that during storms with winds from the northeast the processes of offshore deflection of currents over ridge crests and onshore in the troughs were observed, and during storm events with winds from the southwest a reverse flow pattern over the ridges occurred. Computations of suspended-sediment fluxes identify periods that are consistent with SFCR maintenance mechanisms. Alongshore winds from the northeast drove fluxes offshore on the ridge crest and onshore in the trough that would tend to promote ridge maintenance. However, alongshore winds from the southwest drove opposite circulations. The wind fields are related to different storm types that occur in the region (low pressure systems, cold fronts, and warm fronts). From the limited data set we identify that low pressure systems drive sediment fluxes that tend to promote stability and maintain the SFCRs, while cold front type storms appear to drive circulations that are in the opposite sense and may not be a supporting mechanism for ridge maintenance.

The tug-of-war between the West Philippine Sea and South China Sea Tropical Waters and Intermediate Waters in the Okinawa Trough

NASA Astrophysics Data System (ADS)

Chen, C. T. A.

2015-12-01

It has been known that Kuroshio subsurface waters are the major source of nutrients to the East China Sea continental shelf, a major fishing ground. It has also been known that subsurface waters that upwell onto the shelf are heavily affected by the South China Sea (SCS) Tropical Water and the SCS Intermediate Water which contain more nutrients than the tropical (Smax) and intermediate (Smin) waters from the West Philippine Sea (WPS). A front has been found to separate the tropical and intermediate waters from the SCS and WPS. The reported front in the Okinawa Trough, however, was identified based only on one-time data from a single cross-section in the central Okinawa Trough. Here historical hydrographic data between Mar. 1950 and Dec. 2011 in the Okinawa Trough and its neighborhood are analyzed. A vertical front tilted toward the west is found in all seasons in all years across the World Ocean Circulation Repeated Lines PR 18 and 19 as well as at the PN cross-section in the central Okinawa Trough. The front at the Smax level (sigma theta=24.6-24.9) shows large seasonal and interannual variations. In winter during normal and La Niña periods the presence of the SCS Tropical Water is the most prominent. It is the weakest in autumn during normal periods and in spring during La Nina periods. Yet during El Niño periods the SCS Tropical Water is the most prominent in spring and it becomes the weakest in winter. As for intermediate waters (Smin at sigma theta= 26.7-26.9) the WPS Intermediate Water and SCS Intermediate Water show much weaker seasonality compared with tropical waters although during normal periods in winter the WPS Intermediate Water contribution is slightly larger than during other times. During El Niño periods the WPS Intermediate Water contribution is the smallest but in spring it is much strengthened. On the other hand, the WPS Intermediate Water contribution is the smallest in spring, and the largest in winter during La Niña periods.

South Asian high and Asian-Pacific-American climate teleconnection

NASA Astrophysics Data System (ADS)

Zhang, Peiqun; Song, Yang; Kousky, Vernon E.

2005-11-01

Growing evidence indicates that the Asian monsoon plays an important role in affecting the weather and climate outside of Asia. However, this active role of the monsoon has not been demonstrated as thoroughly as has the variability of the monsoon caused by various impacting factors such as sea surface temperature and land surface. This study investigates the relationship between the Asian monsoon and the climate anomalies in the Asian-Pacific-American (APA) sector. A hypothesis is tested that the variability of the upper-tropospheric South Asian high (SAH), which is closely associated with the overall heating of the large-scale Asian monsoon, is linked to changes in the subtropical western Pacific high (SWPH), the mid-Pacific trough, and the Mexican high. The changes in these circulation systems cause variability in surface temperature and precipitation in the APA region. A stronger SAH is accompanied by a stronger and more extensive SWPH. The enlargement of the SWPH weakens the mid-Pacific trough. As a result, the southern portion of the Mexican high becomes stronger. These changes are associated with changes in atmospheric teleconnections, precipitation, and surface temperature throughout the APA region. When the SAH is stronger, precipitation increases in southern Asia, decreases over the Pacific Ocean, and increases over the Central America. Precipitation also increases over Australia and central Africa and decreases in the Mediterranean region. While the signals in surface temperature are weak over the tropical land portion, they are apparent in the mid latitudes and over the eastern Pacific Ocean.

Altitude Variation of the Plasmapause Signature in the Main Ionospheric Trough

NASA Technical Reports Server (NTRS)

Grebowsky, Joseph M.; Benson, Robert F.; Webb, Phillip A.; Truhlik, Vladimir; Bilitza, Dieter

2009-01-01

The projection of the plasmapause magnetic-field lines to low altitudes, where the light-ion chemistry is dominated by O(+), tends to occur near the minimum electron density in the main (midlatitude) electron density trough at night. With increasing attitude in the trough, where H(+) emerges as the dominant iota on the low-latitude boundary, we have found cases where the plasmapause field lines are located on the sharp low-Latitude side of the trough as expected if this topside ionosphere H(+) distribution varies in step with the plasmapause gradient in the distant plasmasphere. These conclusions are based on near-equatorial crossings of the plasmapause (corresponding to the steep gradient in the dominant species H(+) by the Explorer-45 satellite as determined from electric-field measurements by Maynard and Cauffman in the early 1970s and ISIS-2 ionospheric topside-sounder measurements. The former data have now been converted to digital form and made available at http://nssdcftp.gsfc.nasa.gov. The latter provide samples of nearly coincident observations of ionospheric main trough crossings near the same magnetic-field lines of the Explorer 45-determined equatorial plasmapause. The ISIS-2 vertical electron density profiles are used to infer where the F-region transitions from an O(+) to a H(+) dominated plasma through the main trough boundaries.

[Preparation of polyacrylamide gel electrophoresis for human chorionic gonadotropin chimeric peptide 12 expressed in E. coli].

PubMed

Zou, Yong-Shui; Xu, Wan-Xiang; He, Yuan; Sun, Zhi-Da; Xue, Xiao-Lin

2002-09-01

In recent years, development of chimeric peptide (CP) immunogens is a trend in the vaccinological field. The CPs contain a B cell epitope(s) of target antigen and a promiscuous self - or foreign- T cell epitope(s). However, such constructed CPs were all expressed in prokaryotic or eukaryotic systems at lower levels. To purify the human chorionic gonadotropin (hCG) CP12 expressed in E. coli at the level of about 1% of the total cell proteins, an improved method of preparative gel polyacrylamide gel electrophoresis (PAGE) was developed. The important improvement to routine preparative PAGE involves: (1) running reversed electrophoresis by rearranging the gel- carrying plate when the bromophenol blue band arrived at 1-1.5 centimeter from the bottom of the gel; (2) making a collecting trough between the gel and a dialytic membrane that was used to isolate the upper tank buffer. About 8 fractions were collected at regular intervals of 15 minutes after bromophenol blue running out of gel. And then 0.2 ml was taken from each fraction and the protein was precipitated by sequentially adding trichloroacetic acid and acetone. Each sample was dissolved in 20 microL sample buffer and analyzed and identified by SDS-PAGE and Western blotting. As a result, the hCG CP12 expression product with 95% relative homogeneity was harvested at a 50-100 microgram level after a single-step purification of this preparative PAGE, with respect to the sample which contained 3-4 mg of cell proteins.

Use of rapid prototyping drill template for the expansive open door laminoplasty: A cadaveric study.

PubMed

Rong, Xin; Wang, Beiyu; Chen, Hua; Ding, Chen; Deng, Yuxiao; Ma, Lipeng; Ma, Yanzhao; Liu, Hao

2016-11-01

Trough preparation is a technically demanding yet critical procedure for successful expansive open door laminoplasty (EOLP), requiring both proper position and appropriate bone removal. We aimed to use the specific rapid prototyping drill template to achieve such requirement. The 3D model of the cadaveric cervical spine was reconstructed using the Mimics 17.0 and Geomagic Studio 12.0 software. The drilling template was designed in the 3-Matic software. The trough position was simulated at the medial margin of the facet joint. Two holders were designed on both sides. On the open side, the holder would just allow the drill penetrate the ventral cortex of the lamina. On the hinge side, the holder was designed to keep the ventral cortex of the lamina intact. One orthopedic resident performed the surgery using the rapid prototyping drill template on four cadavers (template group). A control group of four cadavers were operated upon without the use of the template. The deviation of the final trough position from the simulated trough position was 0.18mm±0.51mm in the template group. All the troughs in the template group and 40% of the troughs in the control group were at the medial side of the facet joint. The complete hinge fracture rate was 5% in the template group, significantly lower than that (55%) in the control group (P=0.01). The rapid prototyping drill template could help the surgeon accomplish proper trough position and appropriate bone removal in EOLP on the cadaveric cervical spine. Copyright © 2016 Elsevier B.V. All rights reserved.

Petroleum prospects of Benue trough, Nigeria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nawachukwu, J.I.

1985-04-01

Exploration activities in the Benue trough have been minimal over the years, mainly because of large petroleum deposits found in the adjoining Niger delta and early gas finds in the Anambra basin, south of the Benue trough. The recent increase in exploration activities in the trough has necessitated a reevaluation of the petroleum potentials of the basin. In this study, the time-temperature index (TTI) method was used to evaluate petroleum prospects of the basin. An increase in geothermal gradient resulted in a decrease in depth to the oil window, with the sediments maturing earlier at higher geothermal gradients. At geothermalmore » gradients of 1.5-1.9/sup 0/F/100 ft (2.73.5/sup 0/C/100 m) and maximum TTI values, the Asu River Group and the Eze-Aku Group of sediments are still within the gas-generating stage. The Awgu Shale and the Nkporo Shale are capable of generating gas at geothermal gradients of 2.3-2.7/sup 0/F/100 ft (4.2-4.9/sup 0/C/100 m). The Benue trough is essentially a gas-condensate basin with little oil. Exploration targets in the basin include both the sub-Santonian and superSantonian sediments, with the Eze-Aku Group, Awgu Shale, and Nkporo Shale being more prospective than the stratigraphically lower Asu River Group. In general, the middle Benue trough is considered to be the most prospective area within the trough because depths to the mature zones are moderate (6,600-13,000 ft; 2-4 km). These depths are variable, decreasing northeastward and increasing southwestward toward the Niger delta.« less

Katabatic jumps in the Martian northern polar regions

NASA Astrophysics Data System (ADS)

Spiga, Aymeric; Smith, Isaac

2018-07-01

Martian polar regions host active regional wind circulations, such as the downslope katabatic winds which develop owing to near-surface radiative cooling and sloped topography. Many observations (stratigraphy from radar profiling, frost streaks, spectral analysis of ices) concur to show that aeolian processes play a key role in glacial processes in Martian polar regions. A spectacular manifestation of this resides in elongated clouds that forms within the polar spiral troughs, a series of geological depressions in Mars' polar caps. Here we report mesoscale atmospheric modeling in Martian polar regions making use of five nested domains operating a model downscaling from horizontal resolutions of twenty kilometers to 200 m in a typical polar trough. We show that strong katabatic jumps form at the bottom of polar troughs with an horizontal morphology and location similar to trough clouds, large vertical velocity (up to +3 m/s) and temperature perturbations (up to 20 K) propitious to cloud formation. This strongly suggests that trough clouds on Mars are caused by katabatic jumps forming within polar troughs. This phenomena is analogous to the terrestrial Loewe phenomena over Antarctica's slopes and coastlines, resulting in a distinctive "wall of snow" during katabatic events. Our mesoscale modeling results thereby suggest that trough clouds might be present manifestations of the ice migration processes that yielded the internal cap structure discovered by radar observations, as part of a "cyclic step" process. This has important implications for the stability and possible migration over geological timescales of water ice surface reservoirs-and, overall, for the evolution of Mars' polar caps over geological timescales.

Conceptual design study of concentrator enhanced solar arrays for space applications. 2kW Si and GaAs systems at 1 AU

NASA Technical Reports Server (NTRS)

1980-01-01

The effect of concentration level on the specific power for a deployable, thin, gallium arsenide cell array in geosynchronous orbit for 10 years in conjunction with a two dimensional flat plate trough concentrator (V trough) and also with a multiple flat plate concentrator was investigated as well as the effects for a conventional silicon cell array on a rigid substrate. For application to a thin GaAs array at 1 AU for 10 years, the V trough produces a 19% benefit in specific power and a dramatic reduction in array area, while the multiple flat plate collector design is not only of no benefit, but is a considerable detriment. The benefit it achieves by reducing array area is duplicated by the 2D design. For the silicon array on a rigid substrate, improvement in performance due to a concentrator with ordinary mirror coating is quite small: 9% increase in specific power, and 13% reduction in array area. When the concentrator mirrors are coated with an improved cold mirror coating, somewhat more significant results are obtained: 31% specific power improvement; and 27% area reduction. In both cases, a 10 year exposure reduces BOL output by 23%.

Results of Phase 2 Safety and Feasibility Study of Treatment With Levetiracetam for Prevention of Posttraumatic Epilepsy

PubMed Central

Klein, Pavel; Herr, Daniel; Pearl, Phillip L.; Natale, JoAnne; Levine, Zachary; Nogay, Claude; Sandoval, Fabian; Trzcinski, Stacey; Atabaki, Shireen M.; Tsuchida, Tammy; van den Anker, John; Soldin, Steven J.; He, Jianping; McCarter, Robert

2016-01-01

Objectives To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE). Design Open-label, nonrandomized phase 2 study with 2 arms comparing levetiracetam treatment vs observation. Setting Two level 1 trauma centers. Patients A total of 422 participants 6 years or older with TBI who have a 20% risk for PTE were screened. Of these participants, 205 (48.6%) were eligible. A total of 126 participants were enrolled: 86 adults and 40 children. A total of 66 participants were in the treatment group (46 adults and 20 children), and a total of 60 participants were in the observation group (40 adults and 20 children). Participants presenting within 8 hours after TBI received treatment, and those presenting more than 8 to 24 hours after TBI did not. Intervention Treatment with levetiracetam (55 mg/kg/d) for 30 days starting within 8 hours after injury. Main Outcome Measures Number of adverse events, mood score, number of infections, trough level of levetiracetam, and PTE. Results Of the 66 participants treated with levetiracetam, 2 (3%) stopped treatment owing to toxicity (somnolence). The most common adverse events were fatigue, headache, and somnolence. Mood scores and number of infections did not differ between the treatment and observation groups. Mean trough levels of levetiracetam on days 2 to 30 ranged from 19.6 to 26.7 μg/mL. At 2 years, 13 of 86 adults (15.1%) and 1 of 40 children (2.5%) developed PTE. At 2 years, 5 of 46 treated adults (10.9%) and 8 of 40 untreated adults (20.0%) developed PTE (relative risk, 0.47; P=.18). Conclusion Treatment with 55 mg/kg/d of levetiracetam (a dose with an antiepileptogenic effect on animals) for patients with TBI at risk for PTE is safe and well tolerated, with plasma levels similar to those in animal studies. The findings support further evaluation of levetiracetam treatment for the prevention of PTE. PMID:22777131

Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy.

PubMed

Klein, Pavel; Herr, Daniel; Pearl, Phillip L; Natale, JoAnne; Levine, Zachary; Nogay, Claude; Sandoval, Fabian; Trzcinski, Stacey; Atabaki, Shireen M; Tsuchida, Tammy; van den Anker, John; Soldin, Steven J; He, Jianping; McCarter, Robert

2012-10-01

To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high risk for posttraumatic epilepsy (PTE). Open-label, nonrandomized phase 2 study with 2 arms comparing levetiracetam treatment vs observation. Two level 1 trauma centers. A total of 422 participants 6 years or older with TBI who have a 20% risk for PTE were screened. Of these participants, 205 (48.6%) were eligible. A total of 126 participants were enrolled: 86 adults and 40 children. A total of 66 participants were in the treatment group (46 adults and 20 children), and a total of 60 participants were in the observation group (40 adults and 20 children). Participants presenting within 8 hours after TBI received treatment, and those presenting more than 8 to 24 hours after TBI did not. Treatment with levetiracetam (55 mg/kg/d) for 30 days starting within 8 hours after injury. Number of adverse events, mood score, number of infections, trough level of levetiracetam, and PTE. Of the 66 participants treated with levetiracetam, 2 (3%) stopped treatment owing to toxicity (somnolence). The most common adverse events were fatigue, headache, and somnolence. Mood scores and number of infections did not differ between the treatment and observation groups. Mean trough levels of levetiracetam on days 2 to 30 ranged from 19.6 to 26.7 μg/mL. At 2 years, 13 of 86 adults (15.1%) and 1 of 40 children (2.5%) developed PTE. At 2 years, 5 of 46 treated adults (10.9%) and 8 of 40 untreated adults (20.0%) developed PTE (relative risk, 0.47; P=.18). Treatment with 55 mg/kg/d of levetiracetam (a dose with an antiepileptogenic effect on animals) for patients with TBI at risk for PTE is safe and well tolerated, with plasma levels similar to those in animal studies. The findings support further evaluation of levetiracetam treatment for the prevention of PTE. clinicaltrials.gov Identifier: NCT01463033.

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

PubMed

Jani, Meghna; Chinoy, Hector; Warren, Richard B; Griffiths, Christopher E M; Plant, Darren; Fu, Bo; Morgan, Ann W; Wilson, Anthony G; Isaacs, John D; Hyrich, KimmeL; Barton, Anne

2015-05-01

To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. A total of 331 patients from an observational prospective cohort were selected (160 patients treated with adalimumab and 171 treated with etanercept). Antidrug antibody levels were measured by radioimmunoassay, and drug levels were measured by enzyme-linked immunosorbent assay in 835 serial serum samples obtained 3, 6, and 12 months after initiation of therapy. The association between antidrug antibodies and drug non-trough levels and the treatment response (change in the Disease Activity Score in 28 joints) was evaluated. Among patients who completed 12 months of followup, antidrug antibodies were detected in 24.8% of those receiving adalimumab (31 of 125) and in none of those receiving etanercept. At 3 months, antidrug antibody formation and low adalimumab levels were significant predictors of no response according to the European League Against Rheumatism (EULAR) criteria at 12 months (area under the receiver operating characteristic curve 0.71 [95% confidence interval (95% CI) 0.57, 0.85]). Antidrug antibody-positive patients received lower median dosages of methotrexate compared with antidrug antibody-negative patients (15 mg/week versus 20 mg/week; P = 0.01) and had a longer disease duration (14.0 versus 7.7 years; P = 0.03). The adalimumab level was the best predictor of change in the DAS28 at 12 months, after adjustment for confounders (regression coefficient 0.060 [95% CI 0.015, 0.10], P = 0.009). Etanercept levels were associated with the EULAR response at 12 months (regression coefficient 0.088 [95% CI 0.019, 0.16], P = 0.012); however, this difference was not significant after adjustment. A body mass index of ≥30 kg/m(2) and poor adherence were associated with lower drug levels. Pharmacologic testing in anti-tumor necrosis factor-treated patients is clinically useful even in the absence of trough levels. At 3 months, antidrug antibodies and low adalimumab levels are significant predictors of no response according to the EULAR criteria at 12 months. © 2015 The Authors. Arthritis & Rheumatology is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.

Signal connection for a downhole tool string

DOEpatents

Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Bradford, Kline; Fox, Joe; Briscoe, Michael

2006-08-29

A signal transmission connection for a tool string used in exploration and production of natural resources, namely: oil, gas, and geothermal energy resources. The connection comprises first and second annular elements deployed in cooperative association with each other. The respective elements comprise inductive transducers that are capable of two-way signal transmission between each other, with downhole components of the tool string, and with ground-level equipment. The respective inductive transducers comprise one or more conductive loops housed within ferrite troughs, or within ferrite trough segments. When energized, the conductive loops produce a magnetic field suitable for transmitting the signal. The second element may be rotational in drilling applications. The respective elements may be fitted with electronic equipment to aid and manipulate the transmission of the signal. The first element may also be in communication with the World Wide Web.

Pluto’s Puzzling Patterns and Pits

NASA Image and Video Library

2017-12-08

This image was taken by the Long Range Reconnaissance Imager (LORRI) on NASA's New Horizons spacecraft shortly before closest approach to Pluto on July 14, 2015; it resolves details as small as 270 yards (250 meters). The scene shown is about 130 miles (210 kilometers) across. The sun illuminates the scene from the left, and north is to the upper left. Credits: NASA/JHUAPL/SwRI It seems that the more we see of Pluto, the more fascinating it gets. With its prominent heart-shaped feature, icy mountains, and “snakeskin” terrain, Pluto has already surprised New Horizons scientists with the variety and complexity of its surface features. Now this latest image, from the heart of Pluto’s heart feature, show the plains’ enigmatic cellular pattern (at left) as well as unusual clusters of small pits and troughs (from lower left to upper right). Scientists believe that this area, informally known as Sputnik Planum, is composed of volatile ices such as solid nitrogen. They theorize that the pits and troughs – typically hundreds of meters across and tens of meters deep – are possibly formed by sublimation or evaporation of these ices. However, the reasons for the striking shapes and alignments of these features are a mystery. Adding to the intrigue is that even at this resolution, no impact craters are seen, testifying to the extreme geologic youth of Sputnik Planum. “Pluto is weird, in a good way,” said Hal Weaver, New Horizons project scientist with Johns Hopkins Applied Physics Laboratory in Laurel, Maryland. “The pits, and the way they’re aligned, provide clues about the ice flow and the exchange of volatiles between the surface and atmosphere, and the science team is working hard to understand what physical processes are at play here.” NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

The Effects of Rapid Sedimentation upon Continental Breakup: Kinematic and Thermal Modeling of the Salton Trough, Southern California, Based upon Recent Seismic Images

NASA Astrophysics Data System (ADS)

Han, L.; Hole, J. A.; Lowell, R. P.; Stock, J. M.; Fuis, G. S.

2016-12-01

The Salton Seismic Imaging Project (SSIP) illuminated crustal and upper mantle structure of the Salton Trough, the northern-most rift segment of the Gulf of California plate boundary. The crust is 17-18 km thick and homogeneous for 100 km in the plate motion direction. New crust is being created by distributed rift magmatism, Colorado River sedimentation, and metamorphism of the sediment. A 5 km thick pre-existing crustal layer may still exist. The crust has not broken apart to enable initiation of seafloor spreading. A one-dimensional time-dependent kinematic and thermal model was developed to simulate these observations. We assume that all crustal layers are stretched uniformly during extension. Distributed mafic magmatism and sedimentation are added simultaneously to compensate for the crustal thinning. The ratio of magmatism to sedimentation is constrained by the seismic observations. Heat is transported by thermal conduction and by advection due to stretching of the crust. A constant temperature boundary at the Moho is used to represent partial melting in the upper mantle. Assuming a constant plate motion rate, the zone of active rifting extends linearly with time. The crustal thickness and internal structure also evolve with time. The model constraints are the observed seismic structure and heat flow. The model rapidly reaches quasi-steady state, and could continue for many millions of years. The observed seismic structure and heat flow are reproduced after 3 Myr. The yield strength profile calculated from lithology and model temperature indicates that ductile deformation in the middle and lower crust dominates the crustal rheology. Rapid sedimentation delays crustal breakup and the initiation of seafloor spreading by maintaining the thickness of the crust and keeping it predominantly ductile. This process probably occurs wherever a large river flows into an active rift driven by far-field extension. It may have built passive margins in many locations globally, such as the Gulf of Mexico. This type of passive margin consists of mostly new crust created by magmatism and metamorphism of sediment. Along such margins, metamorphosed sediment could be misinterpreted as stretched pre-existing continental crust.

Silurian extension in the Upper Connecticut Valley, United States and the origin of middle Paleozoic basins in the Québec embayment

USGS Publications Warehouse

Rankin, D.W.; Coish, R.A.; Tucker, R.D.; Peng, Z.X.; Wilson, S.A.; Rouff, A.A.

2007-01-01

Pre-Silurian strata of the Bronson Hill arch (BHA) in the Upper Connecticut Valley, NH-VT are host to the latest Ludlow Comerford Intrusive Suite consisting, east to west, of a mafic dike swarm with sheeted dikes, and an intrusive complex. The rocks are mostly mafic but with compositions ranging from gabbro to leucocratic tonalite. The suite is truncated on the west by the Monroe fault, a late Acadian thrust that carries rocks of the BHA westward over Silurian-Devonian strata of the Connecticut Valley-Gaspe?? trough (CVGT). Dikes intrude folded strata with a pre-intrusion metamorphic fabric (Taconian?) but they experienced Acadian deformation. Twenty fractions of zircon and baddeleyite from three sample sites of gabbrodiorite spanning nearly 40 km yield a weighted 207Pb/206Pb age of 419 ?? 1 Ma. Greenschist-facies dikes, sampled over a strike distance of 35 km, were tholeiitic basalts formed by partial melting of asthenospheric mantle, with little or no influence from mantle or crustal lithosphere. The dike chemistry is similar to mid-ocean ridge, within-plate, and back-arc basin basalts. Parent magmas originated in the asthenosphere and were erupted through severely thinned lithosphere adjacent to the CVGT. Extensive middle Paleozoic basins in the internides of the Appalachian orogen are restricted to the Que??bec embayment of the Laurentian rifted margin, and include the CVGT and the Central Maine trough (CMT), separated from the BHA by a Silurian tectonic hinge. The NE-trending Comerford intrusions parallel the CVGT, CMT, and the tectonic hinge, and indicate NW-SE extension. During post-Taconian convergence, the irregular margins of composite Laurentia and Avalon permitted continued collision in Newfoundland (St. Lawrence promontory) and coeval extension in the Que??bec embayment. Extension may be related to hinge retreat of the northwest directed Brunswick subduction complex and rise of the asthenosphere following slab break-off. An alternative hypothesis is that the basins originated as pull-apart basins between northwest-trending, left-stepping, sinistral strike-slip faults along the southern flanks of the New York and St. Lawrence promontories.

Uganda rainfall variability and prediction

NASA Astrophysics Data System (ADS)

Jury, Mark R.

2018-05-01

This study analyzes large-scale controls on Uganda's rainfall. Unlike past work, here, a May-October season is used because of the year-round nature of agricultural production, vegetation sensitivity to rainfall, and disease transmission. The Uganda rainfall record exhibits steady oscillations of ˜3 and 6 years over 1950-2013. Correlation maps at two-season lead time resolve the subtropical ridge over global oceans as an important feature. Multi-variate environmental predictors include Dec-May south Indian Ocean sea surface temperature, east African upper zonal wind, and South Atlantic wind streamfunction, providing a 33% fit to May-Oct rainfall time series. Composite analysis indicates that cool-phase El Niño Southern Oscillation supports increased May-Oct Uganda rainfall via a zonal overturning lower westerly/upper easterly atmospheric circulation. Sea temperature anomalies are positive in the east Atlantic and negative in the west Indian Ocean in respect of wet seasons. The northern Hadley Cell plays a role in limiting the northward march of the equatorial trough from May to October. An analysis of early season floods found that moist inflow from the west Indian Ocean converges over Uganda, generating diurnal thunderstorm clusters that drift southwestward producing high runoff.

An Analysis of the Environments of Intense Convective Systems in West Africa in 2003

NASA Technical Reports Server (NTRS)

Nicholls, Stephen D.; Mohr, Karen I.

2010-01-01

We investigated the local- and regional-scale thermodynamical and dynamical environments associated with intense convective systems in West Africa during 2003. We identified convective system cases from TRMM microwave imagery, classifying each case by the system minimum 85-GHz brightness temperature and by the estimated elapsed time of propagation from high terrain. The speed of the mid-level jet, the magnitude of the low-level shear, and the surface equivalent potential temperature (theta(sub e)) were greater for the intense cases compared to the non-intense cases, although the differences between the means tended to be small, less than 3K for surface theta(sub e). Hypothesis testing of a series of commonly used intensity prediction metrics resulted in significant results only for low-level metrics such as convective available potential energy and not for any of the mid- or upper-level metrics such as 700-hPa theta(sub e). None of the environmental variables or intensity metrics by themselves or in combination appeared to be reliable direct predictors of intensity. In the regional scale analysis, the majority of intense convective systems occurred in the surface baroclinic zone where surface theta(sub e) exceeded 344 K and the 700-hPa zonal wind speeds were less than -6/ms. Fewer intense cases compared to non-intense cases were associated with African easterly wave troughs. Fewer than 25% of our cases occurred in environments with detectable Saharan dust loads, and the results for intense and non-intense cases were similar. Our results for the regional analysis were consistent with the seasonal movement of the WAM and the intertropical front, regional differences in topography, and AEW energetics.

Evidence and mechanism of Hurricane Fran-Induced ocean cooling in the Charleston Trough

NASA Astrophysics Data System (ADS)

Xie, Lian; Pietrafesa, L. J.; Bohm, E.; Zhang, C.; Li, X.

Evidence of enhanced sea surface cooling during and following the passage of Hurricane Fran in September 1996 over an oceanic depression located on the ocean margin offshore of Charleston, South Carolina (referred to as the Charleston Trough), [Pietrafesa, 1983] is documented. Approximately 4C° of sea surface temperature (SST) reduction within the Charleston Trough following the passage of Hurricane Fran was estimated based on SST imagery from Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-14 polar orbiting satellite. Simulations using a three-dimensional coastal ocean model indicate that the largest SST reduction occurred within the Charleston Trough. This SST reduction can be explained by oceanic mixing due to storm-induced internal inertia-gravity waves.

Tropical Storm Kyle (2002) and cold-air damming: their interactions and impacts on heavy rainfall in the Carolinas

NASA Astrophysics Data System (ADS)

Garcia-Rivera, Jose M.; Lin, Yuh-Lang; Rastigejev, Yevgenii

2016-06-01

The interactions between an Appalachian cold-air damming event and the near passage of Tropical Storm Kyle (2002) along the coastal Carolinas are assessed by using a numerical weather prediction model. As the storm moved along the coastline, it began extra-tropical transition, bringing heavy rains to both the coastal region and inland towards the Piedmont of North Carolina. Our goal is to quantify the effects of both interacting weather systems on heavy precipitation to improve the dynamical understanding of such effects, as well as precipitation forecasts in the study region. A series of sensitivity tests were performed to isolate and quantify the effects of both systems on the total accumulated precipitation. It was found that (a) for this type of along-coast track, the pre-existing cold-air damming played only a minor role on the total accumulated precipitation, (b) the outer circulation of Kyle weakened the cold-air damming due to a redirection of the mean flow away from the east side of the Appalachian Mountains, and (c) the combination of Kyle with a shortwave mid- to upper-level trough and a surface coastal front were responsible for the heavy precipitation experienced in the study area through the advection of moisture, vorticity, and the forcing of upward motion.

Atmospheric circulation patterns associated to the variability of River Ammer floods: evidence from observed and proxy data

NASA Astrophysics Data System (ADS)

Rimbu, N.; Czymzik, M.; Ionita, M.; Lohmann, G.; Brauer, A.

2015-09-01

The relationship between the frequency of River Ammer floods (southern Germany) and atmospheric circulation variability is investigated based on observational Ammer discharge data back to 1926 and a flood layer time series from varved sediments of the downstream Lake Ammersee for the pre-instrumental period back to 1766. A composite analysis reveals that, at synoptic time scales, observed River Ammer floods are associated with enhanced moisture transport from the Atlantic Ocean and the Mediterranean towards the Ammer region, a pronounced trough over Western Europe as well as enhanced potential vorticity at upper levels. We argue that this synoptic scale configuration can trigger heavy precipitation and floods in the Ammer region. Interannual to multidecadal increases in flood frequency as recorded in the instrumental discharge record are associated to a wave-train pattern extending from the North Atlantic to western Asia with a prominent negative center over western Europe. A similar atmospheric circulation pattern is associated to increases in flood layer frequency in the Lake Ammersee sediment record during the pre-instrumental period. We argue that the complete flood layer time-series from Lake Ammersee sediments covering the last 5500 years, contains information about atmospheric circulation variability on inter-annual to millennial time-scales.

Large-Scale Antecedent Conditions Associated with 2014-2015 Winter Onset over North America and mid-Winter Storminess Along the North Atlantic Coast

NASA Astrophysics Data System (ADS)

Bosart, L. F.; Papin, P. P.; Bentley, A. M.; Benjamin, M.; Winters, A. C.

2015-12-01

Winter 2014-2015 was marked by the coldest November weather in 35 years east of the Rockies and record-breaking snowstorms and cold from the eastern Great Lakes to Atlantic Canada in January and February 2015. Record-breaking warmth prevailed across the Intermountain West and Rockies beneath a persistent upper-level ridge. Winter began with a series of arctic air mass surges that culminated in an epic lake-effect snowstorm occurred over western New York before Thanksgiving and was followed by a series of snow and ice storms that disrupted Thanksgiving holiday travel widely. Winter briefly abated in part of December, but returned with a vengeance between mid-January and mid-February 2015 when multiple extreme weather events that featured record-breaking monthly and seasonal snowfalls and record-breaking daily minimum temperatures were observed. This presentation will show how: (1) the recurvature and extratropical transition (ET) of Supertyphoon (STY) Nuri in the western Pacific in early November 2014, and its subsequent explosive reintensification as an extratropical cyclone (EC), disrupted the North Pacific jet stream and downstream Northern Hemisphere (NH) circulation, produced high-latitude ridging and the formation of an omega block over western North America, triggered downstream baroclinic development and the formation of a deep trough over eastern North America, and ushered in winter 2014-2015, (2) the ET/EC of STY Nuri increased subsequent week two predictability over the North Pacific and North America in association with diabatically influenced high-latitude ridge building, and (3) the amplification of the large-scale NH flow pattern beginning in January 2015 resulted in the formation of persistent high-amplitude ridges over northeastern Russia, Alaska, western North America, and the North Atlantic while deep troughs formed over the eastern North Pacific and eastern North America. This persistent amplified flow pattern supported the occurrence of frequent heavy snowstorms, including blizzards, over parts of the northeastern United States and adjacent Atlantic Canada during the latter part of January and much of February 2015.

`Blame' Hawaii for Extreme Cold Air Outbreaks on the US West Coast?

NASA Astrophysics Data System (ADS)

Grotjahn, R.; Zhang, R.

2017-12-01

Short term extreme cold events punctuate the climate record. Though not always captured by monthly or seasonal means, they can have impacts lasting months. Extreme cold air outbreaks affecting the US West Coast are associated with a specific large scale meteorological pattern (LSMP). The LSMP has large meridional displacements of warm and cold air that create a ridge over and south of western Alaska, then a trough downstream moving with the cold air of the CAO, and finally another ridge over the southeastern US. These three features form in that order over several days leading up to the CAO onset. The warm advection creating the Alaskan ridge displaces cold air which is then advected southward along the North American west coast. Our recent work shows that both advections are driven by a lower level highly unusual high pressure center near the Gulf of Alaska. The cold air advection includes a continental interior portion (which sets up an offshore pressure gradient) and a portion off the west coast (air parcels high enough to be little modified before sinking over the US West Coast). In the mid to upper troposphere there are additional cyclonic centers to the south of the Alaskan ridge. Depending on the region compared, the LSMP has notable pattern correlation (up to 0.7) with the Pacific-North American teleconnection (PNA) negative phase pattern. (Others have shown a link between the PNA negative phase and unusual cold over northwestern North America on longer time scales. Here we find a higher frequency LSMP having centers offset from corresponding centers in the negative phase PNA loading pattern.) Even earlier before onset, we find a connection to a stream function structure straddling the equator that shares properties with slow moving equatorial Rossby waves; this pattern includes a trough near Hawaii that appears linked to the Alaskan ridge building that initiates the CAO. Hence, we arrive at our provocative title. All these features in the geopotential and stream function fields are highly significant from bootstrap statistics. The presentation will emphasize the time evolution of these significant features.

North Indian heavy rainfall event during June 2013: diagnostics and extended range prediction

NASA Astrophysics Data System (ADS)

Joseph, Susmitha; Sahai, A. K.; Sharmila, S.; Abhilash, S.; Borah, N.; Chattopadhyay, R.; Pillai, P. A.; Rajeevan, M.; Kumar, Arun

2015-04-01

The Indian summer monsoon of 2013 covered the entire country by 16 June, one month earlier than its normal date. Around that period, heavy rainfall was experienced in the north Indian state of Uttarakhand, which is situated on the southern slope of Himalayan Ranges. The heavy rainfall and associated landslides caused serious damages and claimed many lives. This study investigates the scientific rationale behind the incidence of the extreme rainfall event in the backdrop of large scale monsoon environment. It is found that a monsoonal low pressure system that provided increased low level convergence and abundant moisture, and a midlatitude westerly trough that generated strong upper level divergence, interacted with each other and helped monsoon to cover the entire country and facilitated the occurrence of the heavy rainfall event in the orographic region. The study also examines the skill of an ensemble prediction system (EPS) in predicting the Uttarakhand event on extended range time scale. The EPS is implemented on both high (T382) and low (T126) resolution versions of the coupled general circulation model CFSv2. Although the models predicted the event 10-12 days in advance, they failed to predict the midlatitude influence on the event. Possible reasons for the same are also discussed. In both resolutions of the model, the event was triggered by the generation and northwestward movement of a low pressure system developed over the Bay of Bengal. The study advocates the usefulness of high resolution models in predicting extreme events.

Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report.

PubMed

Sassi, Mouna B; Gaies, Emna; Salouage, Issam; Trabelsi, Sameh; Lakhal, Mohamed; Klouz, Anis

2015-01-01

Tacrolimus is a calcineurin inhibitor primarily metabolized by CYP3A4 and secondarily by CYP3A5. Several drugs can modify tacrolimus blood levels as calcium channel blockers (CCBs). Interaction with nicardipine was reported in some cases. A man with a history of malignant arterial hypertension treated with nicardipine, underwent kidney transplantation. After transplantation, he was treated with tacrolimus, mycophenolate mofetil and corticoids. Therapeutic drug monitoring of tacrolimus was done regularly showing a mean trough concentration (C0) of 24.39 ng/mL with some concentrations reaching 52 ng/mL. After changing nicardipine by prazosine, the first tacrolimus C0 after stopping nicardipine was 3.2 ng/mL. Increase of tacrolimus trough concentrations is due to the inhibition of CYP3A4. Very high levels of tacrolimus suggest the non expression of CYP3A5. Thus, because of the possible lack of the secondary pathway, therapeutic drug monitoring of tacrolimus is highly recommended at the introduction of CCBs and also at its stopping.

Plutonium activities and 240Pu/ 239Pu atom ratios in sediment cores from the east China sea and Okinawa Trough: Sources and inventories

NASA Astrophysics Data System (ADS)

Wang, Zhong-liang; Yamada, Masatoshi

2005-05-01

Plutonium concentrations and 240Pu/ 239Pu atom ratios in the East China Sea and Okinawa Trough sediment cores were determined by isotope dilution inductively coupled plasma mass spectrometry after separation using ion-exchange chromatography. The results showed that 240Pu/ 239Pu atom ratios in the East China Sea and Okinawa Trough sediments, ranging from 0.21 to 0.33, were much higher than the reported value of global fallout (0.18). The highest 240Pu/ 239Pu ratios (0.32-0.33) were observed in the deepest Okinawa Trough sediment samples. These ratios suggested the US nuclear weapons tests in the early 1950s at the Pacific Proving Grounds in the Marshall Islands were a major source of plutonium in the East China Sea and Okinawa Trough sediments, in addition to the global fallout source. It was proposed that close-in fallout plutonium was delivered from the Pacific Proving Grounds test sites via early direct tropospheric fallout and transportation by the North Pacific Equatorial Circulation system and Kuroshio Current into the Okinawa Trough and East China Sea. The total 239 + 240 Pu inventories in the cores were about 150-200% of that expected from direct global fallout; about 46-67% of the total inventories were delivered from the Pacific Proving Grounds. Much higher 239 + 240 Pu inventories were observed in the East China Sea sediments than in sediments of the Okinawa Trough, because in the open oceans, part of the 239 + 240 Pu was still retained in the water column, and continued Pu scavenging was higher over the margin than the trough. According to the vertical distributions of 239 + 240 Pu activities and 240Pu/ 239Pu atom ratios in these cores, it was concluded that sediment mixing was the dominant process in controlling profiles of plutonium in this area. Faster mixing in the coastal samples has homogenized the entire 240Pu/ 239Pu ratio record today; slightly slower mixing and less scavenging in the Okinawa Trough have left the surface sediment ratios closer to the modern North Pacific water end member and higher ratios (0.30-0.34) at the bottom of the cores.

Habitat use by larval fishes in a temperate South African surf zone

NASA Astrophysics Data System (ADS)

Watt-Pringle, Peter; Strydom, Nadine A.

2003-12-01

Larval fishes were sampled in the Kwaaihoek surf zone on the south east coast of South Africa. On six occasions between February and May 2002, larval fishes were collected in two habitat types identified in the inner surf zone using a modified beach-seine net. The surf zone habitats were classified as either sheltered trough areas or adjacent exposed surf areas. Temperature, depth and current measurements were taken at all sites. Trough habitats consisted of a depression in surf topography characterised by reduced current velocities and greater average depth than adjacent surf areas. In total, 325 larval fishes were collected. Of these, 229 were collected in trough and 96 in surf habitats. At least 22 families and 37 species were represented in the catch. Dominant families were the Mugilidae, Sparidae, Atherinidae, and Engraulidae. Dominant species included Liza tricuspidens and Liza richardsonii (Mugilidae), Rhabdosargus holubi and Sarpa salpa (Sparidae), Atherina breviceps (Atherinidae) and Engraulis japonicus (Engraulide). Mean CPUE of postflexion larvae of estuary-dependent species was significantly greater in trough areas. The proportion of postflexion larval fishes in trough habitat was significantly greater than that of preflexion stages, a result that was not apparent in surf habitat sampled. CPUE of postflexion larvae of estuary-dependent fishes was negatively correlated with current magnitude and positively correlated with habitat depth. Mean body length of larval fishes was significantly greater in trough than in surf habitats. These results provide evidence that the CPUE of postflexion larvae of estuary-dependent fishes is higher in trough habitat in the surf zone and this may be indicative of active habitat selection for areas of reduced current velocity/wave action. The implications of this behaviour for estuarine recruitment processes are discussed.

A fixed tilt solar collector employing reversible vee-trough reflectors and vacuum tube receivers for solar heating and cooling systems

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1977-01-01

The usefulness of vee-trough concentrators in improving the efficiency and reducing the cost of collectors assembled from evacuated tube receivers was studied in the vee-trough/vacuum tube collector (VTVTC) project. The VTVTC was analyzed rigorously and various mathematical models were developed to calculate the optical performance of the vee-trough concentrator and the thermal performance of the evacuated tube receiver. A test bed was constructed to verify the mathematical analyses and compare reflectors made out of glass, Alzak and aluminized FEP Teflon. Tests were run at temperatures ranging from 95 to 180 C. Vee-trough collector efficiencies of 35 to 40% were observed at an operating temperature of about 175 C. Test results compared well with the calculated values. Predicted daily useful heat collection and efficiency values are presented for a year's duration of operation temperatures ranging from 65 to 230 C. Estimated collector costs and resulting thermal energy costs are presented. Analytical and experimental results are discussed along with a complete economic evaluation.

Systematic conversion to generic tacrolimus in stable kidney transplant recipients.

PubMed

Rosenborg, Staffan; Nordström, Annica; Almquist, Tora; Wennberg, Lars; Bárány, Peter

2014-04-01

Tacrolimus (Prograf ® ) is a key drug in the immunosuppressive treatment of renal transplant patients. Since the expiration of the patent for Prograf ® , generic preparations have been approved in Europe as bioequivalence has been shown in healthy volunteers. However, few studies have investigated whether patients can be successfully converted from Prograf ® to generic tacrolimus. Tacrolimus drug costs are by far the largest single item in the total drug expenditure for patients with renal disease in the Stockholm area. Considerable reductions in drug costs could be achieved if generic tacrolimus were to be used. The aim of this quality assurance study was to evaluate whether a switch from Prograf ® to generic tacrolimus (Tacrolimus Sandoz ® ) could be safely performed in renal transplant patients. It further aimed to investigate changes of renal function (measured in estimated glomerular filtration rate, eGFR), need for dose changes and to calculate potential drug cost savings as a result of the conversion. We planned to recruit at least 50 patients. Plasma creatinine levels and trough concentrations of tacrolimus were collected from patients with renal transplants at three occasions during treatment with Prograf ® and three times after conversion to Tacrolimus Sandoz ® . The eGFR was calculated before and after the conversion. Sixty-three of 67 enrolled patients (69% males, age 28-80 years) are included in this analysis. The ratio of mean trough concentrations of tacrolimus after comparison with before conversion was 1.02 (90% confidence interval 0.95-1.09). Fourteen patients experienced a change in tacrolimus levels >20% compared with baseline, no patients changed >20% in eGFR. The drug cost saving per daily dose was 33.40 SEK (∼€3.60, -23%). Stable kidney transplant patients treated with Prograf ® can be converted to Tacrolimus Sandoz ® if trough concentrations of tacrolimus and plasma creatinine levels are closely monitored. The conversion brought savings, despite costs for extra monitoring.

Systematic conversion to generic tacrolimus in stable kidney transplant recipients

PubMed Central

Rosenborg, Staffan; Nordström, Annica; Almquist, Tora; Wennberg, Lars; Bárány, Peter

2014-01-01

Background Tacrolimus (Prograf®) is a key drug in the immunosuppressive treatment of renal transplant patients. Since the expiration of the patent for Prograf®, generic preparations have been approved in Europe as bioequivalence has been shown in healthy volunteers. However, few studies have investigated whether patients can be successfully converted from Prograf® to generic tacrolimus. Tacrolimus drug costs are by far the largest single item in the total drug expenditure for patients with renal disease in the Stockholm area. Considerable reductions in drug costs could be achieved if generic tacrolimus were to be used. The aim of this quality assurance study was to evaluate whether a switch from Prograf® to generic tacrolimus (Tacrolimus Sandoz®) could be safely performed in renal transplant patients. It further aimed to investigate changes of renal function (measured in estimated glomerular filtration rate, eGFR), need for dose changes and to calculate potential drug cost savings as a result of the conversion. Methods We planned to recruit at least 50 patients. Plasma creatinine levels and trough concentrations of tacrolimus were collected from patients with renal transplants at three occasions during treatment with Prograf® and three times after conversion to Tacrolimus Sandoz®. The eGFR was calculated before and after the conversion. Results Sixty-three of 67 enrolled patients (69% males, age 28–80 years) are included in this analysis. The ratio of mean trough concentrations of tacrolimus after comparison with before conversion was 1.02 (90% confidence interval 0.95–1.09). Fourteen patients experienced a change in tacrolimus levels >20% compared with baseline, no patients changed >20% in eGFR. The drug cost saving per daily dose was 33.40 SEK (∼€3.60, −23%). Conclusions Stable kidney transplant patients treated with Prograf® can be converted to Tacrolimus Sandoz® if trough concentrations of tacrolimus and plasma creatinine levels are closely monitored. The conversion brought savings, despite costs for extra monitoring. PMID:24944783

The origin of polygonal troughs on the northern plains of Mars

NASA Astrophysics Data System (ADS)

Pechmann, J. C.

1980-05-01

The morphology, distribution, geologic environment and relative age of large-scale polygonal trough systems on Mars are examined. The troughs are steep-walled, flat-floored, sinuous depressions typically 200-800 m wide, 20-120 m deep and spaced 5-10 km apart. The mechanics of formation of tension cracks is reviewed to identify the factors controlling the scale of tension crack systems; special emphasis is placed on thermal cracking in permafrost. It is shown that because of the extremely large scale of the Martian fracture systems, they could not have formed by thermal cracking in permafrost, dessication cracking in sediments or contraction cracking in cooling lava. On the basis of photogeologic evidence and analog studies, it is proposed that polygonal troughs on the northern plains of Mars are grabens.

A vacuum tube vee-trough collector for solar heating and air conditioning applications

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1978-01-01

An analysis is conducted of the performance of a vee-trough vacuum tube collector proposed for use in solar heating and cooling applications. The vee-trough reflector is a triangular sectioned, flat surfaced reflector, whose axis is laid in the East-West direction. A vacuum tube receiver placed at the bottom of the vee-trough collects solar heat most efficiently since convection is completely eliminated. Radiation losses are reduced by use of selective coatings on the absorber. Owing to its high temperature capabilities (300-400 F), the proposed scheme could also be used for power generation applications in combination with an organic Rankine conversion system. It is especially recommended for unattended pumping stations since the reflectors only require reversal once every six months.

Method and apparatus for automatically detecting patterns in digital point-ordered signals

DOEpatents

Brudnoy, David M.

1998-01-01

The present invention is a method and system for detecting a physical feature of a test piece by detecting a pattern in a signal representing data from inspection of the test piece. The pattern is detected by automated additive decomposition of a digital point-ordered signal which represents the data. The present invention can properly handle a non-periodic signal. A physical parameter of the test piece is measured. A digital point-ordered signal representative of the measured physical parameter is generated. The digital point-ordered signal is decomposed into a baseline signal, a background noise signal, and a peaks/troughs signal. The peaks/troughs from the peaks/troughs signal are located and peaks/troughs information indicating the physical feature of the test piece is output.

Method and apparatus for automatically detecting patterns in digital point-ordered signals

DOEpatents

Brudnoy, D.M.

1998-10-20

The present invention is a method and system for detecting a physical feature of a test piece by detecting a pattern in a signal representing data from inspection of the test piece. The pattern is detected by automated additive decomposition of a digital point-ordered signal which represents the data. The present invention can properly handle a non-periodic signal. A physical parameter of the test piece is measured. A digital point-ordered signal representative of the measured physical parameter is generated. The digital point-ordered signal is decomposed into a baseline signal, a background noise signal, and a peaks/troughs signal. The peaks/troughs from the peaks/troughs signal are located and peaks/troughs information indicating the physical feature of the test piece is output. 14 figs.

A Theoretical Investigation of Optical Emission in Solar Flares

NASA Astrophysics Data System (ADS)

Abbett, William Paul

A dynamic theoretical model of a flare loop from its footpoints in the photosphere to its apex in the corona is presented, and the effects of non-thermal heating of the lower atmosphere by accelerated electrons and soft X-ray irradiation from the flare heated transition region and corona are investigated. Important transitions of hydrogen, helium, and singly ionized calcium and magnesium are treated in non-LTE. Three main conclusions are drawn from the models. First, even the strongest of impulsive events can be described as having two phases: a gentle phase characterized by a state of near equilibrium, and an explosive phase characterized by large material flows, and strong hydrodynamic waves and shocks. During the gentle phase, one or possibly two temperature 'plateaus' form in the upper chromosphere. The line emission generated in these regions produces profiles that are generally symmetric and undistorted, in contrast to emission produced during the explosive phase, where large velocity gradients that occur in the upper atmosphere produce line profiles that are highly asymmetric and show large emission peaks and troughs. Second, a significant continuum (or 'white light') brightening results from increased hydrogen recombination radiation in the upper chromosphere at the point where the accelerated electrons deposit the bulk of their energy. Third, there exists a measurable time lag between the brightening of the near wings of Hα and the brightening of the Paschen continuum. This delay is controlled by the amount of time it takes for electron densities in the upper chromosphere to become high enough, and the densities of hydrogen atoms in high energy bound states to become low enough, to allow the number of recombinations to dominate the number of photoionizations in the region.

Seafloor Morphology And Sediment Discharge Of The Storfjorden And Kveithola Palaeo-Ice Streams (NW Barents Sea) During The Last Deglaciation

NASA Astrophysics Data System (ADS)

Camerlenghi, Angelo; Rebesco, Michele; Pedrosa, Mayte; Demol, Ben; Giulia Lucchi, Renata; Urgeles, Roger; Colmenero-Hidalgo, Elena; Andreassen, Karin; Sverre Laberg, Jan; Winsborrow, Monica

2010-05-01

IPY Activity N. 367 focusing on Neogene ice streams and sedimentary processes on high- latitude continental margins (NICE-STREAMS) resulted in two coordinated cruises on the adjacent Storfjorden and Kveithola trough-mouth fans in the NW Barents Sea: SVAIS Cruise of BIO Hespérides, summer 2007, and EGLACOM Cruise of Cruise R/V OGS-Explora, summer 2008. The objectives were to acquire a high-resolution set of bathymetric, seismic and sediment core data in order to decipher the Neogene architectural development of the glacially-dominated NW Barents Sea continental margin in response to natural climate change. The paleo-ice streams drained ice from southern Spitsbergen, Spitsbergen Bank, and Bear Island. The short distance from the ice source to the calving front produced a short residence time of ice, and therefore a rapid response to climatic changes. In the outer trough of southern Storfjorden, lobate moraines superimpose and are cut by very large linear features attributed to mega-iceberg scours. In the adjacent Kveithola trough, a fresh morphology includes mega-scale glacial lineations overprinted by transverse grounding-zone wedges, diagnostic of episodic ice stream retreat. A 15 m thick glacimarine drape suggests an high post-deglaciation sedimentation rate. Preliminary interpretation suggests that the retreat of the Svalbard/Barents Sea Ice Sheet was highly dynamic and that grounded ice persisted on Spitsbergen Bank for some thousands years after the main Barents Sea deglaciation.The Storfjorden continental slope is divided into three wide lobes. Opposite the two northernmost lobes the slope is dominated by straight gullies in the upper part, and deposition of debris lobes on the mid and lower parts. In contrast, the southernmost lobe is characterized by widespread occurrence of submarine landslides. Sediment failure has accompanied the evolution of the southern Storfjorden and Kveithola margin throughout the Late Neogene, with very large mass transport deposits up to 200 m thick in the early phases of the development of the glacially influenced margin. Conversely, the central and northern parts of the Storfjorden margin have prograded without appreciable episodes of mass failure. Sedimentation has occurred through alternate layering of decimeter-thick glacial debris flows deposits, with laminated and acoustically transparent interglacial sediment drape. Gullies and paleo-gullies incise the glacial debris flows and are covered by the interglacial drape. They are formed early during each deglaciation phase, most likely by the erosive action of short-lived hyperpycnal flows generated by sediment-laden subglacial meltwater discharge. In sediment cores thick finely-laminated sedimentary beds on the upper continental slope of the southern part of the margin indicate preferential deposition by settlement of meltwater sediment plumes. High sedimentation rates of plumites may contribute to the slope instability and suggest that meltwater discharge was focused on the southern Storfjorden and Kveithola paleo-ice streams.

Conversion From Twice-Daily Tacrolimus Capsules to Once-Daily Extended-Release Tacrolimus (LCPT): A Phase 2 Trial of Stable Renal Transplant Recipients

PubMed Central

Gaber, A. Osama; Alloway, Rita R.; Bodziak, Kenneth; Kaplan, Bruce; Bunnapradist, Suphamai

2013-01-01

Background LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. Methods In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Prograf) twice-daily were converted to tacrolimus tablets (LCP-Tacro) once-daily; patients continued on LCP-Tacro once-daily for days 8 to 21; trough levels were to be maintained between 5 and 15 ng/mL; 24-hr pharmacokinetic assessments were done on days 7 (baseline pre-switch), 14, and 21. Results Forty-seven patients completed LCP-Tacro dosing per protocol. The mean conversion ratio was 0.71. Pharmacokinetic data demonstrated consistent exposure (AUC) at the lower conversion dose. Cmax (P=0.0001), Cmax/Cmin ratio (P<0.001), percent fluctuation (P<0.0001), and swing (P=0.0004) were significantly lower and Tmax significantly (P<0.001) longer for LCP-Tacro versus Prograf. AUC24 and Cmin correlation coefficients after 7 and 14 days of therapy were 0.86 or more, demonstrating a robust correlation between LCP-Tacro tacrolimus exposure and trough levels. There were three serious adverse events; none were related to study drug and all were resolved. Conclusions Stable kidney transplant patients can be safely converted from Prograf twice-daily to LCP-Tacro. The greater bioavailability of LCP-Tacro allows for once-daily dosing and similar (AUC) exposure at a dose approximately 30% less than the total daily dose of Prograf. LCP-Tacro displays flatter kinetics characterized by significantly lower peak-trough fluctuations. PMID:23715050

Ice-dammed lateral lake and epishelf lake insights into Holocene dynamics of Marguerite Trough Ice Stream and George VI Ice Shelf, Alexander Island, Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Davies, Bethan J.; Hambrey, Michael J.; Glasser, Neil F.; Holt, Tom; Rodés, Angél; Smellie, John L.; Carrivick, Jonathan L.; Blockley, Simon P. E.

2017-12-01

We present new data regarding the past dynamics of Marguerite Trough Ice Stream, George VI Ice Shelf and valley glaciers from Ablation Point Massif on Alexander Island, Antarctic Peninsula. This ice-free oasis preserves a geological record of ice stream lateral moraines, ice-dammed lakes, ice-shelf moraines and valley glacier moraines, which we dated using cosmogenic nuclide ages. We provide one of the first detailed sediment-landform assemblage descriptions of epishelf lake shorelines. Marguerite Trough Ice Stream imprinted lateral moraines against eastern Alexander Island at 120 m at Ablation Point Massif. During deglaciation, lateral lakes formed in the Ablation and Moutonnée valleys, dammed against the ice stream in George VI Sound. Exposure ages from boulders on these shorelines yielded ages of 13.9 to 9.7 ka. Following recession of the ice stream, George VI Ice Shelf formed in George VI Sound. An epishelf lake formed at 15-20 m asl in Ablation and Moutonnée valleys, dated from 9.4 to 4.6 ka, suggesting that the lake was stable and persistent for some 5000 years. Lake-level lowering occurred after this, with the lake level at 12 m at 3.1 ± 0.4 ka and at 5 m asl today. A readvance of the valley glaciers on Alexander Island at 4.4 ± 0.7 ka is recorded by valley glacier moraines overlying epishelf lake sediments. We speculate that the glacier readvance, which occurred during a period of warmth, may have been caused by a dynamic response of the glaciers to a lowering in surface elevation of George VI Ice Shelf.

Outcrop shapes for correlation of Lower Mississippian carbonates in western North America

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haines, F.

1993-03-01

Examination of the sedimentary cycles in Mississippian carbonates in Iowa, Utah, Montana and Alberta shows a hierarchy of stratigraphic subdivisions: large sequences, cycles, rhythmic bands or marker beds, and couplets of laminated and dense beds. The 3 sequences shoal upward from dark mudstone to an oolitic or crinoidal cap beneath a disconformity. Sequence 1 (Horton Creek Member in Illinois, Upper Fitchville in Utah and Lower Banff oolite in Alberta) thins rapidly to fossiliferous limestone at a Waulsortian shelf margin on the southern edge of the Central Montana Trough. Sequence 2 (Hannibal-Chouteau in Missouri, Middle Banff in Alberta, lower Lodgepole cliffmore » in Montana and lower Chinese wall in Utah) thins at a shelf margin which is north-south in western Montana but swings east then northwest around an embayment in NW Montana and SW Alberta. Sequence 3 (Burlington-Keokuk in Iowa, Upper Banff and Pekisko in Alberta, and upper Lodgepole-massive lower Mission Canyon in Utah and Montana) marker beds lose their identity without a shelf margin in NW Montana and SW Alberta. Rhythmic bands, currently under study, demonstrate episodic deposition over large areas, band tops are sometimes bored, hardened and oxidized. Silty bands are used as marker beds. The S-4 marker (Dolby Creek) maintains a similar bed form despite facies changes. Laminated and dense limestone couplets are common in the basinal facies from Utah to Alberta and in the Chouteau formation of Missouri.« less

Active deformation and evolution of the upper forearc slope of the central Ryukyu Arc, northwestern Pacific

NASA Astrophysics Data System (ADS)

Arai, K.; Inoue, T.; Sato, T.

2016-12-01

The Ryukyu Arc, which extend for over 1200 km along the east coast of Asia from Kyushu to Taiwan, and the associated Ryukyu Trench, are products of the subduction of the Philippine Sea Plate beneath the Eurasian Plate. The Okinawa Trough, a back-arc basin located landward of the Ryukyu Arc, formed in the Late Miocene (Gungor et al., 2012) or the Late Pliocene-Early Pleistocene (Sibuet et al., 1998); its formation is a key geologic event associated with complex tectonic movements and changes in the topographic configuration of the Ryukyu Arc. Geological Survey of Japan (GSJ), AIST has started the marine geological mapping project around Ryukyu Arc since the 2008 FY. Multi channel (16 ch) high-resolution seismic profiles were acquired during these cruises by the GI-gun (355cu. inch) or the Cluster-gun (30+30 cu. inch) systems. Survey area in the southeast off Okinawa Island is located on the upper forearc slope along the Ryukyu Trench. Seismic reflections of shelf and the upper forearc slope show no obvious deformation such as the fold and faults parallel to the Ryukyu Trench axis. In contrast, some active faults, which were perpendicular to the Ryukyu Trench axis (NW-SE direction), were observed. An acoustic basement, which is characterized distinct reflector had tilted southeastward (trenchward) and was unconformable overlain by the stratified sediments. These sediments divided into four seismic units. We present the geological history and tectonics of the central Ryukyu Arc.

Southern Sand Dunes

NASA Image and Video Library

2003-01-15

At first glance, this NASA Mars Odyssey image showing impact craters and linear ridges and troughs is typical of the southern highlands. However, upon closer examination migrating sand dunes are observed within the troughs.

Volcanism and massive sulfide formation at a sedimented spreading center, Escanaba Trough, Gorda Ridge, northeast Pacific.

USGS Publications Warehouse

Morton, J.L.; Holmes, M.L.; Koski, R.A.

1987-01-01

Seismic-reflection profiles over the sediment-filled Escanaba Trough at the southern Gorda Ridge reveal a series of volcanic centers that pierce the sediment. The volcanic edifices are 3 to 6 km in diameter and are spaced at 15 to 20 km intervals along the axis of the trough. Composition and form of sulfide samples obtained from the bank suggest significant interaction between hydrothermal fluids and sediment at depth, and deposition of sulfide within the sediment pile.-from Authors

Reflector Technology Development and System Design for Concentrating Solar Power Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adam Schaut

2011-12-30

Alcoa began this program in March of 2008 with the goal of developing and validating an advanced CSP trough design to lower the levelized cost of energy (LCOE) as compared to existing glass based, space-frame trough technology. In addition to showing a pathway to a significant LCOE reduction, Alcoa also desired to create US jobs to support the emerging CSP industry. Alcoa's objective during Phase I: Concept Feasibility was to provide the DOE with a design approach that demonstrates significant overall system cost savings without sacrificing performance. Phase I consisted of two major tasks; reflector surface development and system conceptmore » development. Two specific reflective surface technologies were investigated, silver metallized lamination, and thin film deposition both applied on an aluminum substrate. Alcoa prepared samples; performed test validation internally; and provided samples to the NREL for full-spectrum reflectivity measurements. The final objective was to report reflectivity at t = 0 and the latest durability results as of the completion of Phase 1. The target criteria for reflectance and durability were as follows: (1) initial (t = 0), hemispherical reflectance >93%, (2) initial spectral reflectance >90% for 25-mrad reading and >87% for 7-mrad reading, and (3) predicted 20 year durability of less than 5% optical performance drop. While the results of the reflective development activities were promising, Alcoa was unable to down-select on a reflective technology that met the target criteria. Given the progress and potential of both silver film and thin film technologies, Alcoa continued reflector surface development activities in Phase II. The Phase I concept development activities began with acquiring baseline CSP system information from both CSP Services and the DOE. This information was used as the basis to develop conceptual designs through ideation sessions. The concepts were evaluated based on estimated cost and high-level structural performance. The target criteria for the concept development was to achieve a solar field cost savings of 25%-50% thereby meeting or exceeding the DOE solar field cost savings target of $350/m2. After evaluating various structural design approaches, Alcoa down-selected to a monocoque, dubbed Wing Box, design that utilizes the reflective surface as a structural, load carrying member. The cost and performance potential of the Wing Box concept was developed via initial finite element analysis (FEA) and cost modeling. The structural members were sized through material utilization modeling when subjected to representative loading conditions including wind loading. Cost modeling was utilized to refine potential manufacturing techniques that could be employed to manufacture the structural members. Alcoa concluded that an aluminum intensive collector design can achieve significant cost savings without sacrificing performance. Based on the cost saving potential of this Concept Feasibility study, Alcoa recommended further validation of this CSP approach through the execution of Phase II: Design and Prototype Development. Alcoa Phase II objective was to provide the DOE with a validated CSP trough design that demonstrates significant overall system cost savings without sacrificing performance. Phase II consisted of three major tasks; Detail System Design, Prototype Build, and System Validation. Additionally, the reflector surface development that began in Phase I was continued in Phase II. After further development work, Alcoa was unable to develop a reflective technology that demonstrated significant performance or cost benefits compared to commercially available CSP reflective products. After considering other commercially available reflective surfaces, Alcoa selected Alano's MIRO-SUN product for use on the full scale prototype. Although MIRO-SUN has a lower specular reflectivity compared to other options, its durability in terms of handling, cleaning, and long-term reflectivity was deemed the most important attribute to successfully validate Alcoa's advanced trough architecture. To validate the performance of the Wing Box trough, a 6 meter aperture by 14 meter long prototype trough was built. For ease of shipping to and assembly at NREL's test facility, the prototype was fabricated in two half modules and joined along the centerline to create the Wing Box trough. The trough components were designed to achieve high precision of the reflective surface while leveraging high volume manufacturing and assembly techniques.« less

The gravity field of the Red Sea and East Africa

NASA Astrophysics Data System (ADS)

Makris, Jannis; Henke, Christian H.; Egloff, Frank; Akamaluk, Thomas

1991-11-01

Reevaluation of all gravity data from the Red Sea, the Gulf of Aden and East Africa permitted the compilation of a new Bouguer anomaly map. The intensity of the gravity field and its regional pattern correlate closely with the topographic features of the region. The maximum Bouguer values (> + 100 mGal) are located over the median troughs of the Red Sea and Gulf of Aden. Dense juvenile oceanic crust in these rifts and intruding magmas in stretched continental areas produce excess mass responsible for the anomaly highs. In the Red Sea the orientation of the gravity highs is NW-SE in the south, turning to NE-SW in the north, almost parallel to the Aqaba-Dead Sea strike. This pattern reveals that the present basin axis is not identical with that which formed the Tertiary coastal margins and the pre-Red Sea zones of crustal weakness. In the Gulf of Aden, new oceanic crust along the Tadjura Trench and its eastward extension is also expressed in the Bouguer anomaly map by gravity highs and a sharp bending of the isolines. A maximum of approx. +150 mGal is located over the central section of the Sheba Ridge. Bouguer gravity values over the East African and Yemen Plateaus are of the order of -180 to -240 mGal, indicating significant crustal thickening. On the Somali Plateau, the Marda Fault also has a strong gravity signature that can be traced towards Somalia. By constraining crustal thickness and structure with seismic data and density values from the velocity distribution by means of the Nafe-Drake and Birch relationships, we computed density models for the crust and upper mantle. The crustal thickness is of the order of 40 km beneath the plateaus and only 5 to 6 km at the oceanized parts in the central and southern portions of the Red Sea median trough. The flanks of the southern Red Sea and the corresponding Arabian side are underlain by 12 to 16 km thick stretched continental type crust. Oceanization offshore Sudan and Egypt is asymmetrical. The continental crust terminates abruptly at about 20 km off the coastline, followed by an oceanic crust of early Miocene age that was produced in pull-apart basins. By contrast, the eastern side of the Red Sea trough offshore Saudi Arabia is floored by stretched continental crust that extends far into the sea. Seafloor spreading and the generation of oceanic crust in organized spreading centres are limited to the median troughs off Sudan and the northern part of Ethiopia and commenced approx. 5 m.y. BP. They are absent in the northern Red Sea, where crustal fracturing occurs only in pull-apart basins of Dead Sea-Aqaba orientation distributed in en-echelon pattern.

Northern control of Southern Source Water deglacial circulation in Rockall Trough, N.E. Atlantic.

NASA Astrophysics Data System (ADS)

McCave, I. N. N.; Hibbert, F. D.; Channell, J. E. T.; Austin, W. E. N.

2014-12-01

Core MD04-2822 from northern Rockall Trough at 2300 m water depth contains a high resolution record of changes in the vigour of the deep circulation determined by variation in the Sortable Silt mean size (SS) over the period 21-0 ka (LGM to present). The record has excellent age control from C-14 and correlation of Np(s) to Greenland ice cores (NGRIP GICC05 scale) (Hibbert et al., 2010, JQS, Austin & Hibbert, 2012, QSR). The record displays a slowdown in deep circulation from 20 to 17.5ka, a faster H-1a and slower H-1b (16.4-14.7 ka), a faster B-A with evident slowing at Older Dryas and IACP, and slow YD. The Holocene shows slower flows around 8.4-7.5, 6.3-5.5 and 3.5 -2.7 ka as well as the Little Ice Age. The a/b differentiation of the Heinrich event is mirrored by changes in d18O at NGRIP with boundaries at 17.8 and 16.3 ka on GICC05 tentatively correlated with H-1b. Benthic Carbon isotope (d13C) variations and values are very similar to those found at 3150 m water depth off Portugal (Skinner & Shackleton, 2004, PaleO), where Shackleton et al (2000, PaleO) show that the water mass is strongly SSW influenced in both warm and cold periods. At the present day there is evidence of SSW (LDW of McCartney, 1992 Progr in O) in Rockall Trough from silicate values greater than those of NE Atlantic Deep water of northern overflow origin. We suggest that bottom water in the Trough during deglaciation contained a major component of southern origin. This is consistent with suggested upper bounds of SSW at ~2000 m elsewhere in the N. Atlantic. This water appears to have responded dynamically to northern hemisphere climatic forcing, although supplied from around Antarctica. In this, its behaviour is similar to the changes in circulation vigour recorded by Pa/Th at 4500 m on Bermuda Rise that must also have been dominated by SSW (McManus et al., 2004, Nature) The κARM/κ grain size parameter reflecting fine magnetite grain size proxy which is sensitive to grain sizes well below the SS range indicates progressive fining of magnetic grain size across the Termination, in contrast to the highly variable sortable silt mean size changes. The magnetic grain-size parameter probably reflects deglacial variations in sediment source from Scotland and Ireland and is not related to flow vigour as some have contended.

Novel second-stage solar concentrator for parabolic troughs

NASA Astrophysics Data System (ADS)

Collares-Pereira, Manuel; Mendes, Joao F.

1995-08-01

Conventional parabolic troughs can be combined with second stage concentrators (SSC), to increase temperature and pressure inside the absorber, making possible the direct production of steam, improving substantially the overall system efficiency and leading to a new generation of distributed solar power plants. To attain this objective, research is needed at the optical, thermodynamic, system control, and engineering levels. In what concerns the receiver of such a system, different practical solutions have been proposed recently and in the past for the geometry of the second stage concentrator: CPC type and others. In this work we discuss these solutions and we propose a new one, 100% efficient in energy collection while reaching a total concentration ratio which is almost 65% of the thermodynamic limit. This SSC has an asymmetric elliptical geometry, rendering possible a smooth solution for the reflectors while maintaining a reasonable size for the receiver.

Stable interior, showing center aisle, stalls, and feed troughs. View ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Stable interior, showing center aisle, stalls, and feed troughs. View looking southwest - Fort Hill Farm, Stable, West of Staunton (Roanoke) River between Turkey & Caesar's Runs, Clover, Halifax County, VA

Event sand layers suggesting the possibility of tsunami deposits identified in the upper Holocene sequence nearby the Kuwana fault, central Japan

NASA Astrophysics Data System (ADS)

Niwa, Y.; Sugai, T.; Matsuzaki, H.

2012-12-01

The Kuwana fault is located on coastal area situated on inner part of the Ise Bay, central Japan, which opens to the Nankai Trough. This reverse fault displaces a late Pleistocene terrace surface with 1 to 2 mm/yr of average vertical slip rate, and a topset of delta at several meters, respectively. And, this fault is estimated to have generated two historical earthquakes (the AD 745 Tempyo and the AD 1586 Tensho earthquakes). We identified two event sand layers from upper Holocene sequence on the upthrown side of the Kuwana fault. Upper Holocene deposits in this study area show prograding delta sequence; prodelta mud, delta front sandy silt to sand, and flood plain sand/mud, respectively, from lower to upper. Two sand layers intervene in delta front sandy silt layer, respectively. Lower sand layer (S1) shows upward-coarsening succession, whereas upper sand layer (S2) upward-fining succession. These sand layers contain sharp contact, rip-up crust, and shell fragment, indicating strong stream flow. Radiocarbon ages show that these strong stream flow events occurred between 3000 and 1600 years ago. Decreasing of salinity is estimated from decreasing trend of electrical conductivity (EC) across S1. Based on the possibility that decreasing of salinity can be occurred by shallowing of water depth caused by coseismic uplift, and that S1 can be correlated with previously known faulting event on the Kuwana fault, S1 is considered to be tsunami deposits caused by faulting on the Kuwana fault. On the other hand, S2, which cannot be correlated with previously known faulting events on the Kuwana fault, may be tsunami deposits by ocean-trench earthquake or storm deposits. In the presentation, we will discuss more detail correlation of these sand deposits not only in the upthrown side of the Kuwana fault, but also downthrown side of the fault.

Prospective Observational Evaluation of Time-Dependency of Adalimumab Immunogenicity and Drug Concentrations: The Poetic Study.

PubMed

Ungar, Bella; Engel, Tal; Yablecovitch, Doron; Lahat, Adi; Lang, Alon; Avidan, Benjamin; Har-Noy, Ofir; Carter, Dan; Levhar, Nina; Selinger, Limor; Neuman, Sandra; Natour, Ola Haj; Yavzori, Miri; Fudim, Ella; Picard, Orit; Kopylov, Uri; Chowers, Yehuda; Naftali, Timna; Broide, Efrat; Shachar, Eyal; Eliakim, Rami; Ben-Horin, Shomron

2018-06-01

Adalimumab is usually self-injected at home, making prospective serial-sampling studies challenging and scarce. This has led to a gap in knowledge about evolution of anti-adalimumab antibodies (AAAs) over time and its correlation with clinical and inflammatory outcomes. A program for home visits by physicians at induction, every 3 months and at event of relapse, was established prospectively for Crohn's disease (CD) patients. At each visit, patients' clinical scores were determined and sera were obtained for C-reactive protein, drug, and AAA levels. This cohort was compared to a parallel prospective cohort of infliximab-treated CD patients. In a subgroup of 29 patients, trough and in-between-trough levels were compared, to elucidate the importance of timing of sampling during the injection cycle. Ninety-eight CD patients starting adalimumab were prospectively followed (median follow-up 44 weeks) and 621 serum samples were analyzed. Thirty-three patients (32%) developed AAA; 18/33 (55%) of them as early as week 2, and 26/33 (79%) by week 14. Induction period AAAs were strongly associated with primary non-response (odds ratio (OR) = 5.4, 95% confidence interval (CI): 1.6-17.8, p = 0.005). As compared to antibodies-to-infliximab (ATI), AAA formation rate over time was significantly lower (p = 0.01) and AAA were much more specific-85% of AAA events were associated with loss-of-response compared with 58% rate for ATI (p = 0.01). In 29 patients sampled serially during an injection cycle, levels of drug and AAA seemed comparable between four time-points during a single cycle both in patients with or without AAA (n = 8, n = 21, respectively). When followed prospectively and serially, AAAs are found to arise earlier than previously appreciated and their impact may be more pronounced for primary rather than secondary, non-response. Drug and AAA levels were similar both at trough and in-between injections, enabling to simplify therapeutic drug monitoring of adalimumab.

Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study.

PubMed

Braun, William E; Schold, Jesse D; Stephany, Brian R; Spirko, Rita A; Herts, Brian R

2014-05-01

The two largest studies of mammalian target of rapamycin inhibitor treatment of autosomal dominant polycystic kidney disease (ADPKD) demonstrated no clear benefit on the primary endpoint of total kidney volume (TKV) or on eGFR. The present study evaluated two levels of rapamycin on the 12-month change in (125)I-iothalamate GFR (iGFR) as the primary endpoint and TKV secondarily. In a 12-month open-label pilot study, 30 adult patients with ADPKD were randomly assigned to low-dose (LD) rapamycin (rapamycin trough blood level, 2-5 ng/ml) (LD group, n=10), standard-dose (STD) rapamycin trough level (>5-8 ng/ml) (STD group, n=10), or standard care (SC group, n=10). They were evaluated with iGFR and noncontrast computed tomography. Change in iGFR at 12 months was significantly higher in the LD group (7.7±12.5 ml/min per 1.73 m(2); n=9) than in the SC group (-11.2 ± 9.1 ml/min per 1.73 m(2); n=9) (LD versus SC: P<0.01). Change in iGFR at 12 months in the STD group (1.6 ± 12.1 ml/min per 1.73 m(2); n=8) was not significantly greater than that in the SC group (P=0.07), but it was in the combined treatment groups (LD+STD versus SC: P<0.01). Neither eGFR calculated by the CKD-Epidemiology Collaboration equation nor TKV (secondary endpoint) changed significantly from baseline to 12 months in any of the groups. On the basis of results of the mixed model, during the study, patients in the LD group had significantly lower trough blood levels of rapamycin (mean range ± SD, 2.40 ± 0.64 to 2.90 ± 1.20 ng/ml) compared with those in the STD group (3.93 ± 2.27 to 5.77 ± 1.06 ng/ml) (P<0.01). Patients with ADPKD receiving LD rapamycin demonstrated a significant increase in iGFR compared with those receiving standard care, without a significant effect on TKV after 12 months.

A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Bhatti, Irfan; Thome, Andrew; Smith, Patricia Oxler; Cook-Wiens, Galen; Yeh, Hung Wen; Gaffney, Gary R.; Hellings, Jessica A.

2013-01-01

We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6-17.9); 40 were males…

Solar-power mountain concept

NASA Technical Reports Server (NTRS)

Clarke, V. C., Jr.

1977-01-01

Solar collectors on mountainside collect thermal energy for mountaintop powerplant. Sloped arrangement reduces heat-transport problem of level ground-based collector field. Heated air rises without mechanical pumps and buoyancy force supplies pumping power without further cost. Precision tracking requirement of power towers eliminated by butted-together Winston-type concentrator troughs. Low-cost native rock is used for heat storage.

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

PubMed

Valentino, L A; Pipe, S W; Collins, P W; Blanchette, V S; Berntorp, E; Fischer, K; Ewenstein, B M; Oh, M; Spotts, G

2016-07-01

We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated. The aim of this study was to analyse data from the PKP arm to determine whether peak FVIII levels, AUC and time with FVIII levels in a haemostatically effective range are independent predictors of bleeding during prophylaxis. Post hoc analysis of the association of FVIII levels and AUC with annualized bleeding rate in 34 patients on PKP. During 1 year of PKP, 131 bleeding episodes occurred in 24/34 patients. Average peak FVIII levels ranged from 24 to 168 IU dL(-1) , with higher values associated with a decreased risk for all bleeding (joint and non-joint; P < 0.01) and joint bleeding (P < 0.01). Following rFVIII infusion, median percent of time spent with FVIII levels >20 IU dL(-1) was 22%; median AUC was 1363. Both values were significantly associated with a lower ABR when targeting a 1% trough at 72 h. When PKP was administered every third day, higher peak FVIII levels, higher AUC and more time spent per week with FVIII levels >20 IU dL(-1) provided increased protection from joint and non-joint bleeding. These data highlight the potential impact of variability in individual pharmacokinetic and bleeding risk and support the need for high peak levels and AUC in some patients treated every third day. The findings do not necessarily apply to alternate-day or other prophylactic dosing regimens. © 2016 The Authors. Haemophilia Published by John Wiley & Sons Ltd.

Concentrating Solar Power Projects | Concentrating Solar Power | NREL

Science.gov Websites

construction, or under development. CSP technologies include parabolic trough, linear Fresnel reflector, power Technology-listing by parabolic trough, linear Fresnel reflector, power tower, or dish/engine systems Status

The stability of amoxicillin trihydrate and potassium clavulanate combination in aqueous solutions.

PubMed

Jerzsele, Akos; Nagy, Gábor

2009-12-01

The effect of various environmental factors on the stability of aqueous solutions of amoxicillin-clavulanic acid combination in a veterinary water-soluble powder product was investigated. In the swine industry, the combination is administered via the drinking water, where both substances are quickly decomposed depending on several environmental factors. The degradation rate of the substances was determined in solutions of different water hardness levels (German hardness of 2, 6 and 10) and pH values (3.0, 7.0 and 10.0), and in troughs made of different materials (metal or plastic). Increasing the water hardness decreased the stability of both substances, amoxicillin being more stable at each hardness value than clavulanate. Amoxicillin trihydrate proved to be most stable at an acidic pH, while increasing the pH decreased its stability (P < 0.05). Maximum stability of potassium clavulanate was experienced at neutral pH, while its decomposition rate was significantly higher at acidic and alkaline pH values (P < 0.01). The stability of the amoxicillin-clavulanic acid combination depends mainly on the less stable clavulanate, although the effect of metallic ions significantly increased the decomposition rate of amoxicillin, rendering it less stable in metal troughs than clavulanate (P < 0.05). Therefore, the amoxicillin-clavulanic acid combination should be administered to the animals in soft water, at neutral pH and in plastic troughs.

Channel morphology and its impact on flood passage, the Tianjiazhen reach of the middle Yangtze River

NASA Astrophysics Data System (ADS)

Shi, Yafeng; Zhang, Qiang; Chen, Zhongyuan; Jiang, Tong; Wu, Jinglu

2007-03-01

The Tianjiazhen reach of the middle Yangtze is about 8 km long, and characterized by a narrow river width of 650 m and local water depth of > 90 m in deep inner troughs, of which about 60 m is below the mean sea level. The troughs in the channel of such a large river are associated with regional tectonics and local lithology. The channel configuration plays a critical role in modifying the height and duration of river floods and erosion of the riverbed. The formation of the troughs in the bed of the Yangtze is considered to be controlled by sets of NW-SE-oriented neotectonic fault zones, in which some segments consist of highly folded thick Triassic limestone crossed by the Yangtze River. Several limestone hills, currently located next to the river channel, serve as nodes that create large vortices in the river, thereby accelerating downcutting on the riverbed composed of limestone highly susceptible to physical corrosion and chemical dissolution. Hydrological records indicate that the nodal hills and channel configuration at Tianjiazhen do not impact on normal flow discharges but discharges > 50,000 m 3s - 1 are slowed down for 2-3 days. Catastrophic floods are held up for even longer periods. These inevitably result in elevated flood stages upstream of prolonged duration, affecting large cities such as Wuhan and a very large number of people.

Supersonic burning in separated flow regions

NASA Technical Reports Server (NTRS)

Zumwalt, G. W.

1982-01-01

The trough vortex phenomena is used for combustion of hydrogen in a supersonic air stream. This was done in small sizes suitable for igniters in supersonic combustion ramjets so long as the boundary layer displacement thickness is less than 25% of the trough step height. A simple electric spark, properly positioned, ignites the hydrogen in the trough corner. The resulting flame is self sustaining and reignitable. Hydrogen can be injected at the base wall or immediately upstream of the trough. The hydrogen is introduced at low velocity to permit it to be drawn into the corner vortex system and thus experience a long residence time in the combustion region. The igniters can be placed on a skewed back step for angles at least up to 30 deg. without affecting the igniter performance significantly. Certain metals (platinum, copper) act catalytically to improve ignition.

Decadal Modulation of Repeating Slow Slip Event Activity in the Southwestern Ryukyu Arc Possibly Driven by Rifting Episodes at the Okinawa Trough

NASA Astrophysics Data System (ADS)

Tu, Yoko; Heki, Kosuke

2017-09-01

We studied 38 slow slip events (SSEs) in 1997-2016 beneath the Iriomote Island, southwestern Ryukyu Arc, Japan, using continuous Global Navigation Satellite Systems data. These SSEs occur biannually on the same fault patch at a depth of 30 km on the subducting Philippine Sea Plate slab with average moment magnitudes (Mw) of 6.6. Here we show that the slip accumulation rate (cumulative slip/lapse time) of these SSEs fluctuated over a decadal time scale. The rate increased twice around 2002 and 2013 concurrently with earthquake swarms in the Okinawa Trough. This suggests that episodic activations of the back-arc spreading at the Okinawa Trough caused extra southward movement of the block south of the trough and accelerated convergence at the Ryukyu Trench.

Surface expression of the Chicxulub crater

PubMed

Pope, K O; Ocampo, A C; Kinsland, G L; Smith, R

1996-06-01

Analyses of geomorphic, soil, and topographic data from the northern Yucatan Peninsula, Mexico, confirm that the buried Chicxulub impact crater has a distinct surface expression and that carbonate sedimentation throughout the Cenozoic has been influenced by the crater. Late Tertiary sedimentation was mostly restricted to the region within the buried crater, and a semicircular moat existed until at least Pliocene time. The topographic expression of the crater is a series of features concentric with the crater. The most prominent is an approximately 83-km-radius trough or moat containing sinkholes (the Cenote ring). Early Tertiary surfaces rise abruptly outside the moat and form a stepped topography with an outer trough and ridge crest at radii of approximately 103 and approximately 129 km, respectively. Two discontinuous troughs lie within the moat at radii of approximately 41 and approximately 62 km. The low ridge between the inner troughs corresponds to the buried peak ring. The moat corresponds to the outer edge of the crater floor demarcated by a major ring fault. The outer trough and the approximately 62-km-radius inner trough also mark buried ring faults. The ridge crest corresponds to the topographic rim of the crater as modified by postimpact processes. These interpretations support previous findings that the principal impact basin has a diameter of approximately 180 km, but concentric, low-relief slumping extends well beyond this diameter and the eroded crater rim may extend to a diameter of approximately 260 km.

Comparative analyses of the bacterial community of hydrothermal deposits and seafloor sediments across Okinawa Trough

NASA Astrophysics Data System (ADS)

Wang, Long; Yu, Min; Liu, Yan; Liu, Jiwen; Wu, Yonghua; Li, Li; Liu, Jihua; Wang, Min; Zhang, Xiao-Hua

2018-04-01

As an ideal place to study back-arc basins and hydrothermal eco-system, Okinawa Trough has attracted the interests of scientists for decades. However, there are still no in-depth studies targeting the bacterial community of the seafloor sediments and hydrothermal deposits in Okinawa Trough. In the present study, we reported the bacterial community of the surface deposits of a newly found hydrothermal field in the southern Okinawa Trough, and the horizontal and vertical variation of bacterial communities in the sediments of the northern Okinawa Trough. The hydrothermal deposits had a relatively high 16S rRNA gene abundance but low bacterial richness and diversity. Epsilonproteobacteria and Bacteroidetes were predominant in hydrothermal deposits whereas Deltaproteobacteria, Gammaproteobacteria and Chloroflexi were abundant across all samples. The bacterial distribution in the seafloor of Okinawa Trough was significantly correlated to the content of total nitrogen, and had consistent relationship with total carbon. Gradual changes of sulfur-oxidizing bacteria were found with the distance away from hydrothermal fields, while the hydrothermal activity did not influence the distribution of the major clades of sulfate-reducing bacteria. Higher abundance of the sulfur cycle related genes (aprA and dsrB), and lower abundance of the bacterial ammonia-oxidizing related gene (amoA) were quantified in hydrothermal deposits. In addition, the present study also compared the inter-field variation of Epsilonproteobacteria among multi-types of hydrothermal vents, revealing that the proportion and diversity of this clade were quite various.

New details about the LGM extent and subsequent retreat of the West Antarctic Ice Sheet from the easternmost Amundsen Sea Embayment shelf

NASA Astrophysics Data System (ADS)

Klages, J. P.; Hillenbrand, C. D.; Kuhn, G.; Smith, J. A.; Graham, A. G. C.; Nitsche, F. O.; Frederichs, T.; Arndt, J. E.; Gebhardt, C.; Robin, Z.; Uenzelmann-Neben, G.; Gohl, K.; Jernas, P.; Wacker, L.

2017-12-01

In recent years several previously undiscovered grounding-zone wedges (GZWs) have been described within the Abbot-Cosgrove palaeo-ice stream trough on the easternmost Amundsen Sea Embayment shelf. These GZWs document both the Last Glacial Maximum (LGM; 26.5-19 cal. ka BP) grounding-line extent and the subsequent episodic retreat within this trough that neighbors the larger Pine Island-Thwaites trough to the west. Here we combine bathymetric, seismic, and geologic data showing that 1) the grounding line in Abbot Trough did not reach the continental shelf break at any time during the last glacial period, and 2) a prominent stacked GZW constructed from six individual wedges lying upon another was deposited 100 km upstream from the LGM grounding-line position. The available data allow for calculating volumes for most of these individual GZWs and for the entire stack. Sediment cores were recovered seawards from the outermost GZW in the trough, and from the individual wedges of the stacked GZW in order to define the LGM grounding-line extent, and provide minimum grounding-line retreat ages for the respective positions on the stacked GZW. We present implications of a grounded-ice free outer shelf throughout the last glacial period. Furthermore, we assess the significance of the grounding-line stillstand period recorded by the stacked GZW in Abbot Trough for the timing of post-LGM retreat of the West Antarctic Ice Sheet from the Amundsen Sea Embayment shelf.

Flucytosine Pharmacokinetics in a Critically Ill Patient Receiving Continuous Renal Replacement Therapy.

PubMed

Kunka, Megan E; Cady, Elizabeth A; Woo, Heejung C; Thompson Bastin, Melissa L

2015-01-01

Purpose. A case report evaluating flucytosine dosing in a critically ill patient receiving continuous renal replacement therapy. Summary. This case report outlines an 81-year-old male who was receiving continuous venovenous hemofiltration (CVVH) for acute renal failure and was being treated with flucytosine for the treatment of disseminated Cryptococcus neoformans infection. Due to patient specific factors, flucytosine was empirically dose adjusted approximately 50% lower than intermittent hemodialysis (iHD) recommendations and approximately 33% lower than CRRT recommendations. Peak and trough levels were obtained, which were supratherapeutic, and pharmacokinetic parameters were calculated. The patient experienced thrombocytopenia, likely due to elevated flucytosine levels, and flucytosine was ultimately discontinued. Conclusion. Despite conservative flucytosine dosing for a patient receiving CVVH, peak and trough serum flucytosine levels were supratherapeutic (120 μg/mL at 2 hours and 81 μg/mL at 11.5 hours), which increased drug-related adverse effects. The results indicate that this conservative dosing regimen utilizing the patient's actual body weight was too aggressive. This case report provides insight into flucytosine dosing in CVVH, a topic that has not been investigated previously. Further pharmacokinetic studies of flucytosine dosing in critically ill patients receiving CVVH are needed in order to optimize pharmacokinetic and pharmacodynamic parameters while avoiding toxic flucytosine exposure.

Landslides in Valles Marineris, Mars

NASA Technical Reports Server (NTRS)

Lucchitta, B. K.

1979-01-01

The morphology of the landslides in the Martian equatorial troughs, the geologic structure of the troughs, the time of emplacement, the similarity to terrestrial landslides, and the origin and mechanism of transport are analyzed. About 35 large landslides well-resolved on Viking images were examined, and it is found that the major landslides cover 31,000 sq km of the trough floors, and individual slides range in area from 40 to 7000 sq km. The morphologic variations of the landslides can be attributed mainly to their degree of confinement on trough floors. Many prominent landslides appear to be of similar age and were emplaced after a major faulting that dropped the trough floors. Most sliding occurred after the created scarps were dissected into spurs, gullies, and tributary canyons. Emplacement of the landslides approximately coincided with a late episode of major eruptive activity of the Tharsis volcanoes, and it is suggested that the slides may have originated as gigantic mudflows with slump blocks at their heads. The large size of many landslides is due to the fault scarps as high as 7 km on which they formed in the absence of vigorous fluvial erosion. The landslides suggest that Mars is earthlike in some respects, which may be important for further evaluations.

Morphology-dependent water budgets and nutrient fluxes in arctic thaw ponds

USGS Publications Warehouse

Koch, Joshua C.; Gurney, Kirsty; Wipfli, Mark S.

2014-01-01

Thaw ponds on the Arctic Coastal Plain of Alaska are productive ecosystems, providing habitat and food resources for many fish and bird species. Permafrost in this region creates unique pond morphologies: deep troughs, shallow low-centred polygons (LCPs) and larger coalescent ponds. By monitoring seasonal trends in pond volume and chemistry, we evaluated whether pond morphology and size affect water temperature and desiccation, and nitrogen (N) and phosphorus (P) fluxes. Evaporation was the largest early-summer water flux in all pond types. LCPs dried quickly and displayed high early-summer nutrient concentrations and losses. Troughs consistently received solute-rich subsurface inflows, which accounted for 12 to 42 per cent of their volume and may explain higher P in the troughs. N to P ratios increased and ammonium concentrations decreased with pond volume, suggesting that P and inorganic N availability may limit ecosystem productivity in older, larger ponds. Arctic summer temperatures will likely increase in the future, which may accelerate mid-summer desiccation. Given their morphology, troughs may remain wet, become warmer and derive greater nutrient loads from their thawing banks. Overall, seasonal- to decadal-scale warming may increase ecosystem productivity in troughs relative to other Arctic Coastal Plain ponds. 

A simple model of the effects of the mid-latitude total ion trough in the bottomside F layer on HF radiowave propagation

NASA Astrophysics Data System (ADS)

Lockwood, M.

1981-06-01

Observations of the amplitudes and Doppler shifts of received HF radio waves are compared with model predictions made using a two-dimensional ray-tracing program. The signals are propagated over a sub-auroral path, which is shown to lie along the latitudes of the mid-latitude trough at times of low geomagnetic activity. Generalizing the predictions to include a simple model of the trough in the density and height of the F2 peak enables the explanation of the anomalous observed diurnal variations. The behavior of received amplitude, Doppler shift, and signal-to-noise ratio as a function of the K sub p index value, the time of day, and the season (in 17 months of continuous recording) is found to agree closely with that predicted using the statistical position of the trough as deduced from 8 years of Alouette satellite soundings. The variation in the times of the observation of large signal amplitudes with the K sub p value and the complete absence of such amplitudes when it exceeds 2.75 are two features that implicate the trough in these effects.

Regional stratigraphy of the south polar layered deposits (Promethei Lingula, Mars): "Discontinuity-bounded" units in images and radargrams

NASA Astrophysics Data System (ADS)

Guallini, Luca; Rossi, Angelo Pio; Forget, François; Marinangeli, Lucia; Lauro, Sebastian Emanuel; Pettinelli, Elena; Seu, Roberto; Thomas, Nicolas

2018-07-01

The Mars South Polar Layered Deposits (SPLD) are the result of depositional and erosional events, which are marked by different stratigraphic sequences and erosional surfaces. To unambiguously define the stratigraphic units at regional scale, we mapped the SPLD on the basis of observed discontinuities (i.e., unconformities, correlative discontinuities and conformities), as commonly done in terrestrial modern stratigraphy. This methodology is defined as "Discontinuity-Bounded Units" or allostratigraphy, and is complemented by geomorphological mapping. Our study focuses on Promethei Lingula (PL) and uses both high-resolution images (CTX, HiRISE) and radargrams (SHARAD) to combine surface and sub-surface observations and obtain a 3D geological reconstruction of the SPLD. One regional discontinuity (named AUR1) was defined within the studied stratigraphic succession and is exposed in several non-contiguous outcrops around PL as well as observed at depth within the ice sheet. This is the primary contact between two major depositional sequences, showing a different texture at CTX resolution. The lower sequence is characterized mainly by a "ridge and trough" morphology (Ridge and Trough Sequence; RTS) and the upper sequence shows mainly by a "stair-stepped" morphology (Stair-Stepped Sequence; SSS). On the basis of the observations, we defined two regional "discontinuity-bounded" units in PL, respectively coinciding with RTS and SSS sequences. Our stratigraphic reconstruction provides new hints on the major scale events that shaped this region. Oscillations in Martian axial obliquity could have controlled local climate conditions in the past, affecting the PL geological record.

Geophysical and Geochemical Signatures Associated with Mantle Fluids Beneath an Active Shear Zone, Southwest Japan

NASA Astrophysics Data System (ADS)

Umeda, K.; Asamori, K.; Sueoka, S.; Tamura, H.; Shimizu, M.

2014-12-01

In 1997, the Kagoshima earthquake doublet, consisting of two closely associated Mw ~ 6 strike-slip events, five km and 48 days apart, has occurred in southwest Japan. The location is where an E-W trending discontinuity along 32°N latitude on southern Kyushu Island is clearly defined in GPS velocities, indicating the presence of a highly active left-lateral shear zone. However, there have not been any obvious indications of active faulting at the surface prior to the earthquake doublet, which could be associated with this shear zone. Three-dimensional inversion of magnetotelluric sounding data obtained in the source region of the earthquake doublet reveals a near-vertical conductive zone with a width of 20 km, extending down to the base of the crust and perhaps into the upper mantle toward the Okinawa trough. The prominent conductor corresponds to the western part of the active shear zone. Elevated 3He/4He ratios in groundwaters sampled from hot spring and drinking water wells suggest the emission of mantle-derived helium from the seismic source region. The geophysical and geochemical observations are significant indications that the invasion of mantle fluids into the crust, driven by upwelling asthenosphere from the Okinawa trough, triggers the notable left-lateral shearing in the zone in the present-day subduction system. In addition, the existence of aqueous fluids in and below the seismogenic layer could change the strength of the zones, and alter the local stress regime, resulting in the occurrence of the 1997 earthquake doublet.

P wave crustal velocity structure in the greater Mount Rainier area from local earthquake tomography

USGS Publications Warehouse

Moran, S.C.; Lees, J.M.; Malone, S.D.

1999-01-01

We present results from a local earthquake tomographic imaging experiment in the greater Mount Rainier area. We inverted P wave arrival times from local earthquakes recorded at permanent and temporary Pacific Northwest Seismograph Network seismographs between 1980 and 1996. We used a method similar to that described by Lees and Crosson [1989], modified to incorporate the parameter separation method for decoupling the hypocenter and velocity problems. In the upper 7 km of the resulting model there is good correlation between velocity anomalies and surface geology. Many focal mechanisms within the St. Helens seismic zone have nodal planes parallel to the epicentral trend as well as to a north-south trending low-velocity trough, leading us to speculate that the trough represents a zone of structural weakness in which a moderate (M 6.5-7.0) earthquake could occur. In contrast, the western Rainier seismic zone does not correlate in any simple way with anomaly patterns or focal mechanism fault planes, leading us to infer that it is less likely to experience a moderate earthquake. A ???10 km-wide low-velocity anomaly occurs 5 to 18 km beneath the summit of Mount Rainier, which we interpret to be a signal of a region composed of hot, fractured rock with possible small amounts of melt or fluid. No systematic velocity pattern is observed in association with the southern Washington Cascades conductor. A midcrustal anomaly parallels the Olympic-Wallowa lineament as well as several other geophysical trends, indicating that it may play an important role in regional tectonics. Copyright 1999 by the American Geophysical Union.

Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn’s disease

PubMed Central

Oh, Eun Hye; Ko, Dae-Hyun; Seo, Hyungil; Chang, Kiju; Kim, Gwang-Un; Song, Eun Mi; Seo, Myeongsook; Lee, Ho-Su; Hwang, Sung Wook; Yang, Dong-Hoon; Ye, Byong Duk; Byeon, Jeong-Sik; Myung, Seung-Jae; Yang, Suk-Kyun; Park, Sang Hyoung

2017-01-01

AIM To investigate the clinical implications of infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATI) levels in Crohn’s disease (CD) patients in Asian countries. METHODS IFX-TL and ATI level were measured using prospectively collected samples obtained with informed consent from CD patients being treated at Asan Medical Center, South Korea. We analyzed the correlations between IFX-TLs/ATI levels and the clinical activity of CD (quiescent vs active disease) based on the CD activity index, C-reactive protein level, and physician’s judgment of patients’ clinical status at enrollment. The impact of concomitant immunomodulators was also investigated. RESULTS This study enrolled 138 patients with CD (84 with quiescent and 54 with active disease). In patients with quiescent and active diseases, the median IFX-TLs were 1.423 μg/mL and 0.163 μg/mL, respectively (P < 0.001) and the median ATI levels were 8.064 AU/mL and 11.209 AU/mL, respectively (P < 0.001). In the ATI-negative and -positive groups, the median IFX-TLs were 1.415 μg/mL and 0.141 μg/mL, respectively (P < 0.001). In patients with and without concomitant immunomodulator use, there were no differences in IFX-TLs (0.632 μg/mL and 1.150 μg/mL, respectively; P = 0.274) or ATI levels (8.655 AU/mL and 9.017 AU/mL, respectively; P = 0.083). CONCLUSION IFX-TL/ATI levels were well correlated with the clinical activity in South Korean CD patients. Our findings support the usefulness of IFX-TLs/ATI levels in treating CD patients receiving IFX in clinical practice. PMID:28293096

GPS/acoustic Seafloor Geodetic Observations Near the Nankai Trough Axis

NASA Astrophysics Data System (ADS)

Tadokoro, K.; Yasuda, K.; Fujii, C.; Watanabe, T.; Nagai, S.

2013-12-01

The GPS/acoustic seafloor geodetic observation system, which uses precise acoustic ranging and kinematic GPS positioning techniques, has been developed as a useful tool for observing seafloor crustal deformations associated with plate convergence and with earthquakes that occurred in ocean area including the 2011 Tohoku-oki Earthquake of Mw 9.0. Our research group installed eight seafloor benchmarks for this observation system in source areas of anticipated major interplate earthquakes along the Nankai Trough, off southwestern Japan. We have performed campaign measurement for 4-8 years until the end of 2012. The error of displacement rate is almost 5 mm/y through the monitoring for more than four years. At the northern-most potion of the Nankai (Suruga) Trough, the observed steady horizontal displacement rate is 45 mm/y toward west. Also no significant velocity difference is observed across the trough, indicating strong interplate locking up to the shallowest segments. On the other hand, site velocities are 40 mm/y in the direction of N75W at the central region of the Nankai trough, 70-90 km landward from the trough axis. Although this result is the strong evidence for interplate locking, with coupling ratios of 60-80% on the basis of the back-slip model, it has no resolution for the interplate locking at the most-shallowest segments whose depths are 0-10 km. In other words, seaward up-dip limit of locked zone is never resolved from the present seafloor benchmark network [Tadokoro et al., 2012] . Large co-seismic slips larger than 40-50 m on the shallowest interplate segment [Ito et al., 2011; Fujii et al., 2011; Iinuma et al., 2012] are the cause of the unexpected high tsunami that has attacked the pacific coasts of the Tohoku region during the Tohoku-oki Earthquake; it is, therefore, essential to understand slip deficit or strain accumulation condition near the trench axis, also for the anticipated mega-thrust earthquake at the Nankai Trough. For this reason, we installed a new seafloor benchmark in the vicinity of the Nankai Trough axis, about 15 km landward from the trough axis, on July 16, 2013. In addition, we plan to install another new benchmark on the other side of the Nankai Trough in August of this year, to directly measure the motion of the subducting Philippine Sea Plate. The coupling ratio is calculated from slip deficit divided by convergence rate. We can directly 'measure' the coupling ratio from crustal deformation at the newly-installed station on the Philippine Sea Plate, without using global plate motion models. Acknowledgments: We are grateful to the captain and crews of R/V "Asama" of Mie Prefecture Fisheries Research Institute, Japan. This study has been partly promoted by Ministry of Education, Culture, Sports, Science and Technology, Japanese Government.

Preliminary Micropaleontological Investigation of a Preserved, Late Pleistocene Cypress Forest on the Northern Gulf of Mexico Inner Shelf

NASA Astrophysics Data System (ADS)

Truong, J. T.; DeLong, K. L.; Bentley, S. J.; Xu, K.; Harley, G. L.; Reese, A.; Gonzalez, S.; Obelcz, J.; Caporaso, A.

2017-12-01

Exposed at the bottom of a trough 13 km offshore Orange Beach, AL on the Gulf of Mexico (GOM) shelf in 18 m water depth are exceptionally preserved in situ bald cypress (Taxodium distichum) stumps. Preserved seeds (T. distichum, Cephalanthus occidentalis, Hibiscus lasiocarpos, Liquidambar styraciflua) discovered in core catcher samples illustrate the exceptional preservation of the site. Woody debris samples have come back radiocarbon dead with an exception to samples located in the upper peat layer with 14C ages from 37,350-41,830 years BP. Optically stimulated luminescence and 14C dates, in combination with GOM eustatic sea level curves, suggest the forest was located 30 m above the paleoshoreline. How the forest remained preserved during subaerial exposure of the continental shelf through the Last Glacial Maximum lowstand until ensuing Holocene sea level transgression remains unknown. The R/V Coastal Profiler collected 7 vibracores from the study site in 2015 and an additional 11 in 2016. A single core (DF1) contains facies identified as the Holocene Mississippi-Alabama-Florida sand sheet, a transitional facies of interbedded sand and mud, and a basal floodplain facies in which the stumps reside. This study seeks to identify the location of the Pleistocene-Holocene unconformity and to assist in stratigraphy of the area. Foraminiferal assemblages found within the transitional facies are of a shallow marine environment that suggests Holocene in age. It is hypothesized that a pulse of sea level rise during Marine Isotope Stages 3-4 caused subsequent rapid aggradation of the paleovalley system allowing for preservation through >30 kyrs of subaerial exposure. One of the ultimate goals of this study is to serve as a guide for identification of other possible sites along the gulf coast.

3D Porosity Estimation of the Nankai Trough Sediments from Core-log-seismic Integration

NASA Astrophysics Data System (ADS)

Park, J. O.

2015-12-01

The Nankai Trough off southwest Japan is one of the best subduction-zone to study megathrust earthquake fault. Historic, great megathrust earthquakes with a recurrence interval of 100-200 yr have generated strong motion and large tsunamis along the Nankai Trough subduction zone. At the Nankai Trough margin, the Philippine Sea Plate (PSP) is being subducted beneath the Eurasian Plate to the northwest at a convergence rate ~4 cm/yr. The Shikoku Basin, the northern part of the PSP, is estimated to have opened between 25 and 15 Ma by backarc spreading of the Izu-Bonin arc. The >100-km-wide Nankai accretionary wedge, which has developed landward of the trench since the Miocene, mainly consists of offscraped and underplated materials from the trough-fill turbidites and the Shikoku Basin hemipelagic sediments. Particularly, physical properties of the incoming hemipelagic sediments may be critical for seismogenic behavior of the megathrust fault. We have carried out core-log-seismic integration (CLSI) to estimate 3D acoustic impedance and porosity for the incoming sediments in the Nankai Trough. For the CLSI, we used 3D seismic reflection data, P-wave velocity and density data obtained during IODP (Integrated Ocean Drilling Program) Expeditions 322 and 333. We computed acoustic impedance depth profiles for the IODP drilling sites from P-wave velocity and density data. We constructed seismic convolution models with the acoustic impedance profiles and a source wavelet which is extracted from the seismic data, adjusting the seismic models to observed seismic traces with inversion method. As a result, we obtained 3D acoustic impedance volume and then converted it to 3D porosity volume. In general, the 3D porosities show decrease with depth. We found a porosity anomaly zone with alteration of high and low porosities seaward of the trough axis. In this talk, we will show detailed 3D porosity of the incoming sediments, and present implications of the porosity anomaly zone for the megathrust fault behavior.

Regional circulation around Heard and McDonald Islands and through the Fawn Trough, central Kerguelen Plateau

NASA Astrophysics Data System (ADS)

van Wijk, Esmee M.; Rintoul, Stephen R.; Ronai, Belinda M.; Williams, Guy D.

2010-05-01

The fine-scale circulation around the Heard and McDonald Islands and through the Fawn Trough, Kerguelen Plateau, is described using data from three high-resolution CTD sections, Argo floats and satellite maps of chlorophyll a, sea surface temperature (SST) and absolute sea surface height (SSH). We confirm that the Polar Front (PF) is split into two branches over the Kerguelen Plateau, with the NPF crossing the north-eastern limits of our survey carrying 25 Sv to the southeast. The SPF was associated with a strong eastward-flowing jet carrying 12 Sv of baroclinic transport through the deepest part of Fawn Trough (relative to the bottom). As the section was terminated midway through the trough this estimate is very likely to be a lower bound for the total transport. We demonstrate that the SPF contributes to the Fawn Trough Current identified by previous studies. After exiting the Fawn Trough, the SPF crossed Chun Spur and continued as a strong north-westward flowing jet along the eastern flank of the Kerguelen Plateau before turning offshore between 50°S and 51.5°S. Measured bottom water temperatures suggest a deep water connection between the northern and southern parts of the eastern Kerguelen Plateau indicating that the deep western boundary current continues at least as far north as 50.5°S. Analysis of satellite altimetry derived SSH streamlines demonstrates a southward shift of both the northern and southern branches of the Polar Front from 1994 to 2004. In the direct vicinity of the Heard and McDonald islands, cool waters of southern origin flow along the Heard Island slope and through the Eastern Trough bringing cold Winter Water (WW) onto the plateau. Complex topography funnels flow through canyons, deepens the mixed layer and increases productivity, resulting in this area being the preferred foraging region for a number of satellite-tracked land-based predators.

Convectively-coupled Kelvin waves over the tropical Atlantic and African regions and their influence on Atlantic tropical cyclogenesis

NASA Astrophysics Data System (ADS)

Ventrice, Michael J.

High-amplitude convectively coupled atmospheric Kelvin waves (CCKWs) are explored over the tropical Atlantic during the boreal summer. Atlantic tropical cyclogenesis is found to be more frequent during the passage of the convectively active phase of the CCKW, and most frequent two days after its passage. CCKWs impact convection within the mean latitude of the inter-tropical convergence zone over the northern tropical Atlantic. In addition to convection, CCKWs also impact the large scale environment that favors Atlantic tropical cyclogenesis (i.e., deep vertical wind shear, moisture, and low-level relative vorticity). African easterly waves (AEWs) are known to be the main precursors for Atlantic tropical cyclones. Therefore, the relationship between CCKWs and AEW activity during boreal summer is explored. AEW activity is found to increase over the Guinea Highlands and Darfur Mountains during and after the passage of the convectively active phase of the CCKW. First, CCKWs increase the number of convective triggers for AEW genesis. Secondly, the associated zonal wind structure of the CCKW is found to affect the horizontal shear on the equatorward side of the African easterly jet (AEJ), such that the jet becomes more unstable during and after the passage of the convectively active phase of the CCKW. The more unstable AEJ is assumed to play a role with increased AEW growth. Through the increased number of AEWs propagating over the tropical Atlantic, as well as from the direct impact on convection and the large-scale environment over the tropical Atlantic, CCKWs are recommended to be used as a means for medium-range predictability of Atlantic tropical cyclones. In addition to modulating tropical cyclone activity over the tropical Atlantic, CCKWs might impact the intensification processes of tropical cyclones. A case study highlighting two August 2010 tropical cyclones (Danielle and Earl) is explored for potential CCKW-tropical cyclone interactions. While predicted to intensify by most model guidance, both Danielle and Earl struggled to do so. It is shown that Danielle and Earl interacted with the convectively suppressed phase of an eastward propagating CCKW during the time they were predicted to intensify. Composite analysis shows that during and after the passage of the convectively suppressed phase of the CCKW over the Atlantic, large-scale vertical wind shear increases as a result of anomalous upper-level westerlies collocated with anomalous lower-level easterlies. Large-scale subsidence associated with the convectively suppressed phase of the CCKW causes the atmosphere to dry. Further, when the upper-level westerly wind anomalies associated with the CCKW are located over the equatorial Atlantic, a tropical upper-tropospheric trough (TUTT) develops over the northern tropical Atlantic. TUTTs are upper-level disturbances known to negatively impact the intensity of tropical cyclones. CCKWs over the tropical Atlantic tend to occur during preferable locations of the Madden-Julian Oscillation (MJO). Results show that the MJO significantly modulates Atlantic tropical cyclogenesis using real-time multivariate MJO indices. Like CCKWs, AEW activity is found to vary coherently with MJO passages. Furthermore, the MJO also impacts the large-scale environment that favors for Atlantic tropical cyclogenesis. Therefore in addition to CCKWs, the state of the MJO should be used for Atlantic tropical cyclogenesis medium-range predictability.

The impact of anti-drug antibodies on drug concentrations and clinical outcomes in rheumatoid arthritis patients treated with adalimumab, etanercept, or infliximab: Results from a multinational, real-world clinical practice, non-interventional study

PubMed Central

Moots, Robert J.; Xavier, Ricardo M.; Mok, Chi Chiu; Rahman, Mahboob U.; Tsai, Wen-Chan; Al-Maini, Mustafa H.; Pavelka, Karel; Mahgoub, Ehab; Kotak, Sameer; Korth-Bradley, Joan; Pedersen, Ron; Mele, Linda; Shen, Qi; Vlahos, Bonnie

2017-01-01

Objective To assess the incidence of anti-drug antibodies (ADA) in patients with rheumatoid arthritis (RA) treated with the TNF inhibitors etanercept (ETN), adalimumab (ADL), or infliximab (IFX), and determine the potential relationship with trough drug concentration, efficacy, and patient-reported outcomes. Methods This multi-national, non-interventional, cross-sectional study (NCT01981473) enrolled adult patients with RA treated continuously for 6–24 months with ETN, ADL, or IFX. ADA and trough drug concentrations were measured by independent assays ≤2 days before the next scheduled dose. Efficacy measurements included Disease Activity Score 28-joint count (DAS28), low disease activity (LDA), remission, and erythrocyte sedimentation rate (ESR). Targeted medical histories of injection site/infusion reactions, serum sickness, and thromboembolic events were collected. Results Baseline demographics of the 595 patients (ETN: n = 200; ADL: n = 199; IFX: n = 196) were similar across groups. The mean duration of treatment was 14.6, 13.5, and 13.1 months for ETN, ADL, and IFX, respectively. All ETN-treated patients tested negative for ADA, whereas 31.2% and 17.4% patients treated with ADL and IFX, respectively, tested positive. In ADL- or IFX-treated patients, those with ADA had significantly lower trough drug concentrations. There were negative correlations between trough drug levels and both CRP and ESR in ADL- and IFX-treated patients. DAS28-ESR LDA and remission rates were higher in patients without ADA. The rate of targeted medical events reported was low. Conclusion ADA were detected in ADL- and IFX-treated but not ETN-treated patients. Patients without ADA generally showed numerically better clinical outcomes than those with ADA. Trial registration This study was registered on www.ClinicalTrials.gov (NCT01981473). PMID:28448562

Molten salt parabolic trough system with synthetic oil preheating

NASA Astrophysics Data System (ADS)

Yuasa, Minoru; Hino, Koichi

2017-06-01

Molten salt parabolic trough system (MSPT), which can heat the heat transfer fluid (HTF) to 550 °C has a better performance than a synthetic oil parabolic trough system (SOPT), which can heat the HTF to 400 °C or less. The utilization of HTF at higher temperature in the parabolic trough system is able to realize the design of a smaller size of storage tank and higher heat to electricity conversion efficiency. However, with MSPT there is a great amount of heat loss at night so it is necessary to circulate the HTF at a high temperature of about 290 °C in order to prevent solidification. A new MSPT concept with SOPT preheating (MSSOPT) has been developed to reduce the heat loss at night. In this paper, the MSSOPT system, its performance by steady state analysis and annual performance analysis are introduced.

Balancing vancomycin efficacy and nephrotoxicity: should we be aiming for trough or AUC/MIC?

PubMed

Patel, Karisma; Crumby, Ashley S; Maples, Holly D

2015-04-01

Sixty years later, the question that still remains is how to appropriately utilize vancomycin in the pediatric population. The Infectious Diseases Society of America published guidelines in 2011 that provide guidance for dosing and monitoring of vancomycin in adults and pediatrics. However, goal vancomycin trough concentrations of 15-20 μg/mL for invasive infections caused by methicillin-resistant Staphylococcus aureus were based primarily on adult pharmacokinetic and pharmacodynamic data that achieved an area under the curve to minimum inhibitory concentration ratio (AUC/MIC) of ≥400. Recent pediatric literature shows that vancomycin trough concentrations needed to achieve the target AUC/MIC are different than the adult goal troughs cited in the guidelines. This paper addresses several thoughts, including the role of vancomycin AUC/MIC in dosing strategies and safety monitoring, consistency in laboratory reporting, and future directions for calculating AUC/MIC in pediatrics.

Paleoenvironmental Assessment and Deglacial Chronology of the Onondaga Trough, Onondaga County, New York

USGS Publications Warehouse

Kappel, William M.; Teece, Mark A.

2007-01-01

Introduction The U.S. Geological Survey, in cooperation with the Onondaga Lake Partnership and Onondaga Environmental Institute, has been studying the hydrogeology of the Onondaga Trough since 2002 to determine the movement and concentration of naturally occurring brine in the glacial valley-fill aquifer. Numerous shallow and deep test holes have been drilled to determine the glacial and water-quality stratigraphy in the Onondaga Trough. Organic materials were recovered from the Onondaga Creek, Ninemile Creek, and Harbor Brook valleys, and from lakebed sediments in Onondaga Lake (fig. 1) and age-dated with carbon-isotope analysis techniques. This report summarizes the carbon-isotope data collected from 1996 through 2006 in the Onondaga Trough. The results of these analyses provide a means to understand the deglaciation of the watershed and the development of the watershed from barren glacial sediment to a forested ecosystem.

Formations in Context (or, what is it?)

NASA Image and Video Library

2018-04-02

This image from NASA's Mars Reconnaissance Orbiter is a close-up of a trough, along with channels draining into the depression. Some HiRISE images show strange-looking formations. Sometimes it helps to look at Context Camera images to understand the circumstances of a scene -- like this cutout from CTX 033783_1509 -- which here shows an impact crater with a central peak, and a collapse depression with concentric troughs just north of that peak. On the floor of the trough is some grooved material that we typically see in middle latitude regions where there has been glacial flow. These depressions with concentric troughs exist elsewhere on Mars, and their origins remain a matter of debate. NB: The Context Camera is another instrument onboard MRO, and it has a larger viewing angle than HiRISE, but less resolution capability than our camera. https://photojournal.jpl.nasa.gov/catalog/PIA22348

Oblique H.F. radiowave propagation in the main trough region of the ionosphere

NASA Astrophysics Data System (ADS)

Lockwood, M.; Mitchell, V. B.

1980-12-01

The propagation of 7.335 MHz, CW signals over a 5212 km subauroral, west-east path is studied. Measurements and semiempirical predictions are made of the amplitude distributions and Doppler shifts of the received signals. The observed amplitude distribution is fitted with a numerical fading model, yielding the power losses suffered by the signals during propagation via the predominating modes. The mid-latitude trough in the F2 peak ionization density is predicted by a statistical model to be at the latitudes of this path at these times and at low K sub p values; a sharp cut-off in low-power losses at a mean K sub p of 2.75 strongly implicates the trough in the propagation of these signals. It is shown that a simple extension of this model to allow for the trough can reproduce the form of the observed diurnal variation.

Revisit of Criteria and Evidence for the Tectonic Erosion vs Accretion in East Asian Margin

NASA Astrophysics Data System (ADS)

Kimura, G.; Hamahashi, M.

2015-12-01

Accretionary and erosive margins provide tectonic end-members in subduction zone and how these tectonic processes might be recorded and recognizable in ancient subduction complexes remains a challenging issue. Tectonic erosion includes sediment subduction and basal erosion along the plate boundary megathrust and drags down the crust of the upper plate into the mantle. Geologic evidence for the erosion is commonly based on lost geological tectono-stratigraphic data, i.e. gaps in the record and indirect phenomena such as subsidence of the forearc slopes. A topographically rough surface such as seamount has been suggested to work like an erosive saw carving the upper plate. Another mechanism of basal erosion has been suggested to be hydrofracturing of upper plate materials due to dehydration-induced fluid pressures, resulting in entrainment of upper plate materials into the basal décollement. Considering the interaction between the ~30 km thick crust of the upper plate and subducting oceanic plate, a subduction dip angle of ~15°, and convergent rate of ~10 cm/year, at least ~1 Ma of continuous basal erosion is necessary to induce clear subsidence of the forearc because the width of plate interface between the upper crustal and subducting plates is about 115 km (30/cos15°). In several examples of subduction zones, for example the Japan Trench and the Middle America Trench off Costa Rica, the subsidence of a few thousand metres of the forearc, combined with a lack of accretionary prism over a period of several million years, suggest that the erosive condition needs to be maintained for several to tens of million years.Such age gaps in the accretionary complex, however, do not automatically imply that tectonic erosion has taken place, as other interpretations such as no accretion, cessation of subduction, and/or later tectonic modification, are also possible. Recent drilling in the forearc of the Nankai Trough suggests that the accretion was ceased between ~12 Ma to ~8 Ma due to the transference of subduction from the Pacific Plate to the Philippine Sea Plate, as opposed to the continuous subduction of the Phillipine Sea Plate with subduction erosion.

On the Possible Role of Gently Sloping Topography in Influencing the Nature of Convective Storms: A Case Study on the High Plains of the U. S.

NASA Astrophysics Data System (ADS)

Bluestein, H. B.; Weiss, C.; Rotunno, R.; Reif, D. W.; Romine, G. S.

2016-12-01

On 27 May 2015 a quasi-stationary supercell in the northern Texas Panhandle produced several tornadoes, before it evolved into a mesoscale convective system. The pre-storm environment was characterized by relatively weak midlevel winds from the west and surface winds from the south/southwest, such that the 0 - 6 km vertical shear was too weak for supercells to have evolved. There was, however, an increase in speed and backing of the surface wind to the easterly/southeasterly direction during the afternoon, so that the 0 - 6 km shear exceeded 20 m s-1, the approximate threshold for supercell formation. The approximate motion of a convective storm without taking into account shear-related or gust-front propagation is the mean wind in the lowest 6 km. With an increase in the easterly component of the surface winds, the mean wind in the lowest 6 km, in the absence of any increase in westerlies at 6 km, decreased. Some physical mechanisms that could be responsible for the backing and increase in easterly component of the surface wind are as follows: (a) the approach of a synoptic-scale, upper-level trough, with its attendant pre-trough, quasi-geostrophic-induced ascent accompanied by surface convergence, an increase in surface vorticity, and concomitant drop in surface pressure, so that east of the region of ascent a westward-directed pressure-gradient forced develops; (b) surface heating on a surface that slopes upward to the west, such that a westward-directed pressure-gradient force develops; (c) the westward movement of a low-level cold pool that had developed in pre-existing, upstream convective storms; (d) the downward mixing of easterly momentum aloft; and (e) the diurnal inertial oscillation in boundary-layer wind due to the diurnal change in vertical mixing of momentum. It is hypothesized that for this case the primary mechanism was (b). A WRF forecast is described in which evidence is presented in favor of our hypothesis. An estimate will also be given of how much backing and increase in surface wind could be explained by heating on the sloping terrain and also climatological changes in wind speed and direction during the afternoon based on surface mesonet data will be shown. The results of this study could have applications to the study of convection anywhere around the globe where there is gently sloping terrain.

Meso-beta scale numerical simulation studies of terrain-induced jet streak mass/momentum perturbations

NASA Technical Reports Server (NTRS)

Lin, Yuh-Lang; Kaplan, Michael L.

1995-01-01

Mesoscale model simulations provide insight into the complex jet streak adjustments on 11-12 July 1981 that preceded the first of two significant gravity wave events to have been generated over the Rocky Mountains in Montana. Simulations employing a variety of terrain treatments indicate that prior to wave formation, geostrophic adjustment processes modified the structure of the mid-upper tropospheric jet streak by creating secondary jetlets to the southeast of the polar jet streak in proximity to the gravity wave generation region. This simulated restructuring of the mid-upper tropospheric jet streak is the result of a four stage process. During stage 1, the wind adjusts to the mass field as the jet streak exit region propagates into the inflection point between the upstream trough and downstream ridge in the height field. Stage 2 is initiated as the mass field is forced to adjust to the new ageostrophic wind field created during stage 1. Stage 3 is defined by a second geostrophic adjustment process occurring in a similar manner but to the south and east of the adjustment which occurs during stage 1. A low-level mesoscale jetlet is formed during stage 4 in response to the low-level pressure falls that are established during stage 3. The perturbation of this jetlet, caused by orographically-induced adiabatic and diabatic physical processes, is the likely mechanism responsible for the generation of the first and second episode of observed gravity waves. The dynamics responsible for this wave episode are discussed as differential surface sensible heating inducing an orographically-forced mountain-plains solenoid, resulting in the formation of additional mesoscale jetlets and internal gravity waves. Also discussed is how convective latent heating modifies the numerically simulated terrain-induced internal gravity waves, especially their amplitude and phase velocities, which provide better agreement with those wave characteristics observed in nature. Finally, the three-dimensional linear response of a zonally uniform barotropic flow in a vertically unbounded, continuously stratified, Boussinesq atmosphere which is perturbed from geostrophic equilibrium is investigated.

On the Revealing Firsthand Probing of Ocean-Ice-Atmosphere Interactions off Sabrina Coast During NBP1402

NASA Astrophysics Data System (ADS)

Huber, B. A.; Orsi, A. H.; Zielinski, N. J.; Durkin, W. J., IV; Clark, P.; Wiederwohl, C. L.; Rosenberg, M. A.; Gwyther, D.; Greenbaum, J. S.; Lavoie, C.; Shevenell, A.; Leventer, A.; Blankenship, D. D.; Gulick, S. P. S.; Domack, E. W.

2014-12-01

Diverse interactions of winds, currents and ice around Antarctica dictate how, where and when the world's densest waters form and massive floating ice shelves and glaciers melt, as well as control sea surface gas exchange and primary productivity. Compelled by recent rate estimates of East Antarctic Ice Sheet mass loss, we contrast the paths and mixing histories of oceanic waters reaching the continental ice edge off the Sabrina and Adelie coasts relying on the unique set of synoptic shipboard measurements from NBP1402 (swath bathymetry, ADCP, underway CTD). Analysis of historical hydrography and sea ice concentration fields within the Mertz Polynya indicates the apparent effect of evolving ocean-ice-atmosphere interactions on the characteristics of local Shelf Water (SW) sources to current outflow of newly formed Antarctic Bottom Water (AABW). A polynya dominated water mass structure similar to that observed off the Adelie Coast before the removal of the Mertz Ice Tongue was expected to the west of the Dalton Ice Tongue (DIT). However, we found no evidence of dense SW off Sabrina Coast, which may lessen the region's preconceived influence to global meridional overturning. Present sea ice production within the eastern Dalton Polynya is overshadowed by freshwater input to relatively stable interior upper waters. The Antarctic Coastal Current (ACoC) picks up distinct meltwater contributions along the DIT western flank and in front of the Moscow University Ice Shelf (MUIS) and Totten Glacier (TG). Unlike over other highly influential margins to global sea level rise, there is no evidence of local cross-shelf inflow and mixing of warm Circumpolar Deep Water. Relatively cold thermocline waters from the continental slope enter the eastern trough off Sabrina Coast, and they are swiftly steered poleward by complex underlying topography. Meltwater export from beneath the MUIS and TG is observed at newly discovered trenches that effectively constrain sub-cavity inflow to low salinity near-freezing waters drawn from intermediate levels of the adjacent westward flowing ACoC. Winds, currents and ice interactions observed off Sabrina Coast during NBP1402 are most likely widespread, in view of reported decadal freshening of upper waters over the Antarctic continental shelf and their localized AABW outflows.

Electrically-Active Convection and Tropical Cyclogenesis in the Atlantic and East Pacific

NASA Technical Reports Server (NTRS)

Leppert, Kenneth D., II; Petersen, Walter A.

2010-01-01

It has been hypothesized that deep, intense convective-scale "hot" towers may aid the process of tropical cyclogenesis and intensification through dynamic and thermodynamic feedbacks on the larger meso-to-synoptic scale circulation. In this study, we make use of NCEP Reanalysis data and Tropical Rainfall Measurement Mission (TRMM) lightning imaging sensor (LIS), precipitation radar (PR), and microwave imager (TMI) data to investigate the role that widespread and/or intense lightning-producing convection (i.e., "electrically-hot towers") present in African easterly waves (AEWs) may play in tropical cyclogenesis over the Atlantic, Caribbean, and East Pacific regions. NCEP Reanalysis 700 hPa meridional winds for the months of June to November for the years 2001-2009 were analyzed for the domain of 5degN-20degN and 130degW-20degE in order to partition individual AEWs into northerly, southerly, trough, and ridge phases. Subsequently, information from National Hurricane Center (NHC) storm reports was used to divide the waves into developing and non-developing waves and to further divide the developing waves into those waves that spawned storms that only developed to tropical storm strength and those that spawned storms that reached hurricane strength. The developing waves were also divided by the region in which they developed. To help determine the gross nature of the smaller convective scale, composites were created of all developing and non-developing waves as a function of AEW wave phase over the full analysis domain and over various smaller longitude bands by compositing TRMM PR, TMI, LIS, and IR brightness temperature data extracted from the NASA global-merged IR brightness temperature dataset. Finally, similar composites were created using various NCEP variables to assess the nature of the larger scale environment and circulation. Results suggest a clear distinction between developing and non-developing waves as developing waves near their region of development in terms of the intensity of convection (indicated by lightning flash rate), coverage of cold cloudiness (indicated by the percentage of a 2.5deg by 2.5deg box covered by IR brightness temperatures less than 210 K), and large-scale variables, such as midlevel moisture and upper-level upward motion. For example, waves that developed in the East Pacific longitude band (i.e., 130degW-95degW) were observed in that band to have a flash rate of 56.4 flashes/day, a coverage by brightness temperatures less than 210 K equal to 2.2%, a 700-hPa specific humidity anomaly of 0.4 g/kg, and a 300-hPa omega value of -0.04 Pascals/s in the trough phase compared to the non-developing wave trough values of 22.1 flashes/day, a coverage by brightness temperatures less than 210 K equal to 0.9%, a 700-hPa specific humidity anomaly of -0.3 g/kg, and a 300-hPa omega value of -0.01 Pascals/s.

Elevated Voriconazole Level Associated With Hallucinations and Suicidal Ideation: A Case Report.

PubMed

Jansen, Jeffrey W; Sen, Sumon K; Moenster, Ryan P

2017-01-01

Voriconazole, a broad-spectrum antifungal, has been associated with visual and auditory hallucinations. We report the case of patient being treated with voriconazole for pulmonary aspergillosis who developed visual hallucinations and new suicidal ideation with plan. Voriconazole troughs were supratherapeutic (9.0 mcg/mL) and the patient was positive for the CYP2C19*1/*2 allele.

The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.

2014-08-20

We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for Cmore » IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.« less

A simple Lagrangian forecast system with aviation forecast potential

NASA Technical Reports Server (NTRS)

Petersen, R. A.; Homan, J. H.

1983-01-01

A trajectory forecast procedure is developed which uses geopotential tendency fields obtained from a simple, multiple layer, potential vorticity conservative isentropic model. This model can objectively account for short-term advective changes in the mass field when combined with fine-scale initial analyses. This procedure for producing short-term, upper-tropospheric trajectory forecasts employs a combination of a detailed objective analysis technique, an efficient mass advection model, and a diagnostically proven trajectory algorithm, none of which require extensive computer resources. Results of initial tests are presented, which indicate an exceptionally good agreement for trajectory paths entering the jet stream and passing through an intensifying trough. It is concluded that this technique not only has potential for aiding in route determination, fuel use estimation, and clear air turbulence detection, but also provides an example of the types of short range forecasting procedures which can be applied at local forecast centers using simple algorithms and a minimum of computer resources.

Five years of beach drainage survey on a macrotidal beach (Quend-Plage, northern France)

NASA Astrophysics Data System (ADS)

Bain, Olivier; Toulec, Renaud; Combaud, Anne; Villemagne, Guillaume; Barrier, Pascal

2016-07-01

A drainage system was installed in 2008 on the macrotidal beach of Quend-Plage, close to Abbeville (Somme, northern France), following a period of significant erosion of recreational areas. The "Direction départementale des territoires et de la mer" (French Coastal Department Authority) has requested a biannual survey in order to validate the beach drainage setup and its efficiency. This paper presents the methodology used for this survey, and the response of the coastal system to this soft engineering method for preventing erosion. These five years of drainage operation have strongly modified the morphology of the beach. Three main modifications occurred: (i) accretion of the upper beach and foredune, (ii) erosion of the lower and middle beach and (iii) a slight shift in directions of the beach bars and troughs. These morphological changes finally led to the stabilization of the beach.

Layering transitions and Schlieren textures in Langmuir films of two organic radicals.

PubMed

Gallani, J-L; Bourgogne, C; Nakatsuji, S

2004-11-09

Two paramagnetic radicals have been investigated in terms of their film-forming properties at the air-water interface. Although the radicals failed to display any mesomorphic behavior in the bulk, they were found prone to built-up multilayer films on the Langmuir trough. The molecules seem to dimerize in the upper layers of the films that exhibit striking Schlieren textures when observed with Brewster angle microscopy. These Schlieren textures, together with the ability to form multilayers, indicate that the molecules came close to displaying smectic mesomorphism. A tentative model of the layers' structure is proposed, and a suggestion for synthesizing new molecules with actual mesomorphism is offered. The presented results show that the study of the behavior of molecules at the air-water interface can shed a new light on their behavior in the bulk and help in the design of new magnetic mesogens.

Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross-sectional pharmacodynamic study based on peak and trough plasma levels.

PubMed

Hawes, E M; Deal, A M; Funk-Adcock, D; Gosselin, R; Jeanneret, C; Cook, A M; Taylor, J M; Whinna, H C; Winkler, A M; Moll, S

2013-08-01

Knowledge of anticoagulation status during dabigatran therapy may be desirable in certain clinical situations. To determine the coagulation tests that are most useful for assessing dabigatran's anticoagulant effect. Peak and trough blood samples from 35 patients taking dabigatran 150 mg twice daily, and one sample each from 30 non-anticoagulated individuals, were collected. Mass spectrometry and various coagulation assays were performed. 'Therapeutic range' was defined as the range of plasma dabigatran concentrations determined by mass spectrometry between the 2.5th and 97.5th percentiles of all values. The therapeutic range was 27-411 ng mL(-1) . The prothrombin time (PT) and activated partial thromboplastin time (APTT), determined with multiple reagents, and activated clotting time (ACT) were insensitive to therapeutic dabigatran: 29%, 18% and 40% of samples had a normal PT, APTT, and ACT, respectively. However, normal PT, ACT and APTT ruled out dabigatran levels above the 75th percentile. The thrombin clotting time (TCT) correlated well and linearly with dabigatran levels below the 50th percentile, but was unmeasurable above it. The dilute thrombin time, ecarin clotting time and ecarin chromogenic assay showed linear correlations with dabigatran levels over a broad range, and identified therapeutic and supratherapeutic levels. The prothrombin time, APTT and ACT are often normal in spite of therapeutic dabigatran plasma levels. The TCT is useful for detecting minimal dabigatran levels. The dilute thrombin time and chromogenic and clotting ecarin assays accurately identify therapeutic and supratherapeutic dabigatran levels. This trial is registered at www.clinicaltrials.gov (#NCT01588327). © 2013 International Society on Thrombosis and Haemostasis.

The formation of a large summertime Saharan dust plume: Convective and synoptic-scale analysis

PubMed Central

Roberts, A J; Knippertz, P

2014-01-01

Haboobs are dust storms produced by the spreading of evaporatively cooled air from thunderstorms over dusty surfaces and are a major dust uplift process in the Sahara. In this study observations, reanalysis, and a high-resolution simulation using the Weather Research and Forecasting model are used to analyze the multiscale dynamics which produced a long-lived (over 2 days) Saharan mesoscale convective system (MCS) and an unusually large haboob in June 2010. An upper level trough and wave on the subtropical jet 5 days prior to MCS initiation produce a precipitating tropical cloud plume associated with a disruption of the Saharan heat low and moistening of the central Sahara. The restrengthening Saharan heat low and a Mediterranean cold surge produce a convergent region over the Hoggar and Aïr Mountains, where small convective systems help further increase boundary layer moisture. Emerging from this region the MCS has intermittent triggering of new cells, but later favorable deep layer shear produces a mesoscale convective complex. The unusually large size of the resulting dust plume (over 1000 km long) is linked to the longevity and vigor of the MCS, an enhanced pressure gradient due to lee cyclogenesis near the Atlas Mountains, and shallow precipitating clouds along the northern edge of the cold pool. Dust uplift processes identified are (1) strong winds near the cold pool front, (2) enhanced nocturnal low-level jet within the aged cold pool, and (3) a bore formed by the cold pool front on the nocturnal boundary layer. PMID:25844277

Future sea-level rise from Greenland's main outlet glaciers in a warming climate.

PubMed

Nick, Faezeh M; Vieli, Andreas; Andersen, Morten Langer; Joughin, Ian; Payne, Antony; Edwards, Tamsin L; Pattyn, Frank; van de Wal, Roderik S W

2013-05-09

Over the past decade, ice loss from the Greenland Ice Sheet increased as a result of both increased surface melting and ice discharge to the ocean. The latter is controlled by the acceleration of ice flow and subsequent thinning of fast-flowing marine-terminating outlet glaciers. Quantifying the future dynamic contribution of such glaciers to sea-level rise (SLR) remains a major challenge because outlet glacier dynamics are poorly understood. Here we present a glacier flow model that includes a fully dynamic treatment of marine termini. We use this model to simulate behaviour of four major marine-terminating outlet glaciers, which collectively drain about 22 per cent of the Greenland Ice Sheet. Using atmospheric and oceanic forcing from a mid-range future warming scenario that predicts warming by 2.8 degrees Celsius by 2100, we project a contribution of 19 to 30 millimetres to SLR from these glaciers by 2200. This contribution is largely (80 per cent) dynamic in origin and is caused by several episodic retreats past overdeepenings in outlet glacier troughs. After initial increases, however, dynamic losses from these four outlets remain relatively constant and contribute to SLR individually at rates of about 0.01 to 0.06 millimetres per year. These rates correspond to ice fluxes that are less than twice those of the late 1990s, well below previous upper bounds. For a more extreme future warming scenario (warming by 4.5 degrees Celsius by 2100), the projected losses increase by more than 50 per cent, producing a cumulative SLR of 29 to 49 millimetres by 2200.

Age and paleoenvironment of the imperial formation near San Gorgonio Pass, Southern California

USGS Publications Warehouse

McDougall, K.; Poore, R.Z.; Matti, J.

1999-01-01

Microfossiliferous marine sediments of the Imperial Formation exposed in the Whitewater and Cabazon areas, near San Gorgonio Pass, southern California, are late Miocene in age and were deposited at intertidal to outer neritic depths, and possibly upper bathyal depths. A late Miocene age of 7.4 to >6.04 Ma is based on the ranges of age-diagnostic benthic foraminifers (Cassidulina delicata and Uvigerina peregrina), planktic foraminifers (Globigerinoides obliquus, G. extremus, and Globigerina nepenthes; zones N17-N19), and calcareous nannoplankton (Discoaster brouweri, D. aff. D. surculus, Reticulofenestra pseudoumbilicata, Sphenolithus abies, and S. neoabies; zones CN9a-CN11) coupled with published K/Ar dates from the underlying Coachella Formation (10.1 ?? 1.2 Ma; Peterson, 1975) and overlying Painted Hill Formation (6.04 ?? 0.18 and 5.94 ?? 0.18 Ma; J. L. Morton in Matti and others, 1985 and Matti and Morton, 1993). Paleoecologic considerations (sea-level fluctuations and paleotemperature) restrict the age of the Imperial Formation to 6.5 through 6.3 Ma. Benthic foraminiferal assemblages indicate that the Imperial Formation in the Whitewater and Cabazon sections accumulated at inner neritic to outer neritic (0-152 m) and possibly upper bathyal (152-244 m) depths. Shallowing to inner neritic depths occurred as the upper part of the section was deposited. This sea-level fluctuation corresponds to a global highstand at 6.3 Ma (Haq and others, 1987). Planktic foraminifers suggest an increase in surface-water temperatures upsection. A similar increase in paleotemperatures is interpreted for the North Pacific from 6.5 to 6.3 Ma (warm interval W10 of Barron and Keller, 1983). Environmental contrasts between the Whitewater and Cabazon sections of the Imperial Formation provide evidence for right-lateral displacements on the Banning fault, a late Miocene strand of the San Andreas fault system. The Cabazon section lies south of the Banning fault, and has been displaced west relative to the Whitewater sections. The Cabazon section was deposited at greater depths, suggesting that it accumulated farther offshore than the Whitewater section. If the Salton Trough was a southward-opening, elongated northwest-southeast basin similar to the modern Gulf of California, the Cabazon sequence probably has been displaced right-laterally from a position farther southeast of the Whitewater sequence. This relation requires late Miocene displacements greater than the present 12 km cross-fault separation between the two Imperial sections in the San Gorgonio Pass area.

Concentrating Solar Power Projects - DEWA CSP Trough Project |

Science.gov Websites

: Parabolic trough Turbine Capacity: Net: 600.0 MW Gross: 600.0 MW Status: Under development Start Year: 2020 Ground: 2018 Start Production: 2020 PPA/Tariff Rate: 7.3 US cents per kWh Participants Developer(s): ACWA

Landslides in Valles Marineris, Mars.

USGS Publications Warehouse

Lucchitta, B.K.

1979-01-01

Large landslides in the Martian equatorial troughs have been investigated with respect to morphology, geologic structure of the troughs, time of emplacement, similarity to terrestrial landslides, and origin and mechanism of transport. The morphologic variations of the landslides can be attributed mainly to their degree of confinement on trough floors. The huge size of many landslides is due to their occurrence on fault scarps that may have attained several kilometers in height in the absence of vigorous fluvial erosion on Mars. The mechanical efficiency of the Martian landslides is high but in accord with predictions from large landslides on earth. -from Author

Optical and mechanical tolerances in hybrid concentrated thermal-PV solar trough.

PubMed

Diaz, Liliana Ruiz; Cocilovo, Byron; Miles, Alexander; Pan, Wei; Blanche, Pierre-Alexandre; Norwood, Robert A

2018-05-14

Hybrid thermal-PV solar trough collectors combine concentrated photovoltaics and concentrated solar power technology to harvest and store solar energy. In this work, the optical and mechanical requirements for optimal efficiency are analyzed using non-sequential ray tracing techniques. The results are used to generate opto-mechanical tolerances that can be compared to those of traditional solar collectors. We also explore ideas on how to relieve tracking tolerances for single-axis solar collectors. The objective is to establish a basis for tolerances required for the fabrication and manufacturing of hybrid solar trough collectors.

Baby Spider: Growth of a Martian Trough Network

NASA Image and Video Library

2016-12-20

This image from NASA Mars Reconnaissance Orbiter shows the growth of a branching network of troughs carved by thawing carbon dioxide over the span of three Martian years. This process is believed to also form larger radially patterned channel features known as Martian "spiders." The image is one of three taken by the High Resolution Imaging Science Experiment (HiRISE) camera on NASA's Mars Reconnaissance Orbiter and included in a report on the first detection of such troughs persisting and growing, from one Mars year to the next. An animation is available at http://photojournal.jpl.nasa.gov/catalog/PIA21257

Optimization of woven jute/glass fibre-reinforced polyester hybrid composite solar parabolic trough collector

NASA Astrophysics Data System (ADS)

Reddy, K. S.; Singla, Hitesh

2017-07-01

In the present work, structural analysis of 5.77m × 4m woven jute (J)/glass (G) fibre-reinforced polyester hybrid composite solar parabolic trough is carried out based on trough parameters to obtain the minimum RMS local slope deviation, termed as SDx value under gravity loading. The optimization is done by varying parameters viz. direction and size of reinforced conduits, stacking number and sequence of hybrid trough laminate at fibre orientation of Δθ=45° and Δθ=60° amongst the layers at 0° collector angle. The analysis revealed that the configuration in which the conduits are placed in both X and Y directions is preferred over other configurations to scale down the effect of wind loads. Furthermore it has been observed that laminate of the order [0°G/45°G/-45°J/90°J]s undergoes minimum surface deformation amongst all the other configurations at conduit reinforcement in both X and Y directions for a conduit thickness of 0.75 mm and radius of 10 mm and obtains the overall SDx value of 1.3492 mrad. The results shows that proposed trough model is very promising and evolves a cost effective system.

Investigating the reasons of variability in Si IV and C IV broad absorption line troughs of quasars

NASA Astrophysics Data System (ADS)

Stathopoulos, Dimitrios; Lyratzi, Evangelia; Danezis, Emmanuel; Antoniou, Antonios; Tzimeas, Dimitrios

2017-09-01

In this paper we analyze the C IV and Si IV broad absorption troughs of two BALQSOs (J101056.69+355833.3, J114548.38+393746.6) to the individual components they consist of. By analyzing a BAL trough to its components we have the advantage to study the variations of the individual absorbing systems in the line of sight and not just the variations of the whole absorption trough or the variations of selected portions of BAL troughs exhibiting changes. We find that the velocity shifts and FWHMs (Full Width at Half Maximum) of the individual components do not vary between an interval of six years. All variable components show changes in the optical depths at line centers which are manifested as variations in the EW (Equivalent Width) of the components. In both BALQSOs, over corresponding velocities, Si IV has higher incidence of variability than C IV. From our analysis, evidence is in favour of different covering fractions between C IV and Si IV. Finally, although most of our results favour the crossing cloud scenario as the cause of variability, there is also strong piece of evidence indicating changing ionization as the source of variability. Thus, a mixed situation where both physical mechanisms contribute to BAL variability is the most possible scenario.