Quantification of incidental mediastinal and hilar irradiation delivered during definitive stereotactic body radiation therapy for peripheral non-small cell lung cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martin, Kate L.; Gomez, Jorge; Nazareth, Daryl P.

2012-07-01

To determine the amount of incidental radiation dose received by the mediastinal and hilar nodes for patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). Fifty consecutive patients with NSCLC, treated using an SBRT technique, were identified. Of these patients, 38 had a prescription dose of 60 Gy in 20-Gy fractions and were eligible for analysis. For each patient, ipsilateral upper (level 2) and lower (level 4) paratracheal, and hilar (level 10) nodal regions were contoured on the planning computed tomography (CT) images. Using the clinical treatment plan, dose and volume calculations were performed retrospectivelymore » for each nodal region. SBRT to upper lobe tumors resulted in an average total ipsilateral mean dose of between 5.2 and 7.8 Gy for the most proximal paratracheal nodal stations (2R and 4R for right upper lobe lesions, 2L and 4L for left upper lobe lesions). SBRT to lower lobe tumors resulted in an average total ipsilateral mean dose of between 15.6 and 21.5 Gy for the most proximal hilar nodal stations (10R for right lower lobe lesions, 10 l for left lower lobe lesions). Doses to more distal nodes were substantially lower than 5 Gy. The often substantial incidental irradiation, delivered during SBRT for peripheral NSCLC of the lower lobes to the most proximal hilar lymph nodes may be therapeutic for low-volume, subclinical nodal disease. Treatment of peripheral upper lobe lung tumors delivers less incidental irradiation to the paratracheal lymph nodes with lower likelihood of therapeutic benefit.« less

Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation.

PubMed

Pakhale, Smita Sakha; Hadjiliadis, Denis; Howell, David N; Palmer, Scott M; Gutierrez, Carlos; Waddell, Thomas K; Chaparro, Cecilia; Davis, R Duane; Keshavjee, Shaf; Hutcheon, Michael A; Singer, Lianne G

2005-09-01

Lung transplantation is an established treatment modality for a number of chronic lung diseases. Long-term survival after lung transplantation is limited by chronic allograft dysfunction, usually manifested by bronchiolitis obliterans syndrome. We describe a case series with upper lobe fibrosis, a novel presentation of chronic allograft dysfunction. We reviewed lung transplants at the Toronto General Hospital and Duke University Hospital from 1990 to 2002 and identified patients with upper lobe fibrosis. Thirteen of 686 patients (6 women) developed upper lobe fibrosis (Toronto, 9; Duke, 4); 12 of 13 had bilateral transplants. The median age at diagnosis was 42 years (range, 19-70). Primary diagnoses were cystic fibrosis, 6; emphysema, 4; sarcoidosis, 1; and pulmonary fibrosis, 2 patients. Radiographic diagnosis was made at a median of 700 days post-transplant (range, 150-2,920). Pulmonary function tests demonstrated predominantly a progressively worsening restrictive pattern. Open lung biopsy specimens revealed dense interstitial fibrosis, with occasional features of obliterative bronchitis, bronchiolitis obliterans obstructive pneumonia, and aspiration. Nine patients died at a median follow-up of 2,310 days (range, 266-3,740), 8 due to respiratory failure. Upper lobe fibrosis is a novel presentation of chronic allograft dysfunction in lung transplant recipients and is differentiated from bronchiolitis obliterans syndrome on the basis of physiologic and radiologic findings.

A "reverse direction" technique of single-port left upper pulmonary resection.

PubMed

Zhang, Min; Sihoe, Alan D L; Du, Ming

2016-08-01

Single-port video-assisted thoracoscopic surgery (VATS) left upper lobectomy is difficult amongst all the lobes. At the beginning of single-port lobectomies, the upper lobes were believed not to be amenable for single-port approach due to the difficult angulation for staplers. Gonzalez reported the first single-port VATS left upper lobectomy in 2011. We report a new technique of single-port VATS left upper lobectomy with the concept of "reverse direction". We divide the apical-anterior arterial trunk with upper vein in the last. The procedure sequence is described as follows: posterior artery, lingular artery, bronchus and finally upper vein & apical-anterior arterial trunk. This method could overcome the angular limitations frequently encountered in single-port VATS procedures; reduce the risk of injuries to pulmonary artery; broaden the indications of single-port the upper lobe of the left lung (LUL) to include hypoplastic lung fissures. Limitations of this new practice include the enlargement or severe calcifications of hilar and bronchial lymph nodes. A "reverse direction" technique of single-port left upper pulmonary resection is feasible and safe.

Utility of blind forceps biopsy of the main carina and upper-lobe carina in patients with non-small cell lung cancer.

PubMed

Gunen, H; Kizkin, O; Tahaoglu, C; Aktas, O

2001-02-01

Preoperative detection of non-small cell lung cancer (NSCLC) metastasis to the main carina and upper-lobe carina can alter the operative approach, preclude further staging procedures, and save many patients from thoracotomy. This study assessed whether bronchoscopic forceps biopsy of the normal-appearing main carina and upper-lobe carina (blind biopsy) ipsilateral to the primary NSCLC lesion improved the accuracy of cancer staging and helped guide the management of these patients. A prospective study of 52 patients was carried out at the SSK Süreyyapasa Center for Chest Disease and Cardiothoracic Surgery. Over a 6-month period, we bronchoscopically evaluated 52 consecutive NSCLC patients who were radiologically classified as operable. At least five blind forceps biopsy specimens were obtained from the main carina and/or upper-lobe carina during each patient's initial fiberoptic bronchoscopic examination. Biopsy specimens were collected from the main carina and upper-lobe carina in 51 and 17 patients, respectively. Initially, all patients were staged and evaluated for operability in standard fashion, without histologic assessment of the blind biopsy specimens. We then restaged the disease and reassessed the patients' operability in light of the biopsy findings. Metastasis was histologically diagnosed in seven patients (13.7%) who underwent main carina biopsy and in four patients (23.5%) who underwent upper-lobe carina biopsy. Cancer-positive blind biopsy results changed the status of 25% (6 of 24) of patients from operable to inoperable, and changed the surgical approach in 11.1% (2 of 18) of patients who ultimately did undergo surgery. We found no statistical relationship between metastasis to either carina and tumor type, stage of disease, visibility of the tumor on fiberoptic bronchoscopy, primary tumor location, T status, or N status (p > 0.05). A blind forceps biopsy of the main carina and upper-lobe carina ipsilateral to the lesion site should be done routinely at initial bronchoscopic examination of all radiologically operable patients with suspected lung cancer. This type of screening can save a significant number of NSCLC patients from inappropriate or unnecessary thoracotomy and further staging procedures with their associated morbidity and risk.

Computed tomography of lobar collapse: 2. Collapse in the absence of endobronchial obstruction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Naidich, D.P.; McCauley, D.I.; Khouri, N.F.

1983-10-01

The computed tomographic appearance of collapse without endobronchial obstruction is reviewed. These 57 cases were classified by the etiology of collapse. The largest group consisted of 29 patients with passive atelectasis, i.e., collapse secondary to fluid, air, or both in the pleural space. Twenty-three of 29 proved secondary to malignant pleural disease. Computed tomography accurately predicted a malignant etiology in 22 of 23 cases. The second largest group of patients had lobar collapse secondary to cicatrization from chronic inflammation. In all cases the underlying etiology was tuberculosis. Radiation caused adhesive atelectasis in six patients secondary to a lack of productionmore » of surfactant. In each case a sharp line of demarcation could be defined between normal and abnormal collapsed pulmonary parenchyma. Three cases of unchecked tumor growth caused a peripheral form of collapse (replacement atelectasis). This form of collapse was characterized by an absence of endobronchial obstruction and extensive tumor not delineated by the normal boundaries of the pulmonary lobes.« less

Effects of manual percussion during postural drainage on lung volumes and metabolic status in healthy subjects.

PubMed

Leelarungrayub, Jirakrit; Eungpinichpong, Wichai; Klaphajone, Jakkrit; Prasannarong, Mujalin; Boontha, Kritsana

2016-04-01

The aim of this study was to evaluate the influence of manual percussion during three different positions of postural drainage (PD) on lung volumes and metabolic status. Twenty six healthy volunteers (13 women and 13 men), with a mean age of 20.15 ± 1.17 years, participated. They were randomized into three standard positions of PD (upper, middle, or lower lobes) and given manual percussion at a frequency of 240 times per minute for 5 min. Lung volumes, including tidal volume (TV), inspiratory reserve volume (IRV), expiratory reserve volume (ERV) and vital capacity (VC); and metabolic status, such as oxygen consumption (VO2), carbon dioxide (VCO2), respiratory rate (RR), and minute ventilation (VE) were evaluated. The lung volumes showed no statistical difference in VC or IRV from percussion during PD in all positions, except for the lower lobe, where increased TV and decreased ERV were found when compared to PD alone. Furthermore, percussion during PD of the upper and middle lobes did not affect RR or VE, when compared to PD alone. In addition, percussion during PD of the middle and lower lobes increased VO2 and VCO2 significantly, when compared to PD alone, but it did not influence PD of the upper lobe. This study indicated that up to 5 min of manual percussion on PD of the upper and middle lobes is safe mostly for lung volumes, RR, and VE, but it should be given with care in PD conditions of the lower lobe. Copyright © 2015 Elsevier Ltd. All rights reserved.

Migrating Lobar Atelectasis of the Right Lung: Radiologic Findings in Six Patients

PubMed Central

Kim, Tae Sung; Hwang, Jung Hwa; Choo, In Wook; Lim, Jae Hoon

2000-01-01

Objective To describe the radiologic findings of migrating lobar atelectasis of the right lung. Materials and Methods Chest radiographs (n = 6) and CT scans (n = 5) of six patients with migrating lobar atelectasis of the right lung were analyzed retrospectively. The underlying diseases associated with lobar atelectasis were bronchogenic carcinoma (n = 4), bronchial tuberculosis (n = 1), and tracheobronchial amyloidosis (n = 1). Results Atelectasis involved the right upper lobe (RUL) (n = 3) and both the RUL and right middle lobe (RML) (n = 3). On supine anteroposterior radiographs (n = 5) and on an erect posteroanterior radiograph (n = 1), the atelectatic lobe(s) occupied the right upper lung zone, with a wedge shape abutting onto the right mediastinal border. On erect posteroanterior radiographs (n = 6), the heavy atelectatic lobe(s) migrated downward, forming a peri- or infrahilar area of increased opacity and obscuring the right cardiac margin. Erect lateral radiographs (n = 4) showed inferior shift of the anterosuperiorly located atelectatic lobe(s) to the anteroinferior portion of the hemithorax. Conclusion Atelectatic lobe(s) can move within the hemithorax according to changes in a patient's position. This process involves the RUL or both the RUL and RML. PMID:11752926

Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation

PubMed Central

Taranto-Montemurro, Luigi; Sands, Scott A.; Edwards, Bradley A.; Azarbarzin, Ali; Marques, Melania; de Melo, Camila; Eckert, Danny J.; White, David P.; Wellman, Andrew

2017-01-01

We recently demonstrated that desipramine reduces the sleep-related loss of upper airway dilator muscle activity and reduces pharyngeal collapsibility in healthy humans without obstructive sleep apnoea (OSA). The aim of the present physiological study was to determine the effects of desipramine on upper airway collapsibility and apnoea–hypopnea index (AHI) in OSA patients. A placebo-controlled, double-blind, randomised crossover trial in 14 OSA patients was performed. Participants received treatment or placebo in randomised order before sleep. Pharyngeal collapsibility (critical collapsing pressure of the upper airway (Pcrit)) and ventilation under both passive (V′0,passive) and active (V′0,active) upper airway muscle conditions were evaluated with continuous positive airway pressure (CPAP) manipulation. AHI was quantified off CPAP. Desipramine reduced active Pcrit (median (interquartile range) −5.2 (4.3) cmH2O on desipramine versus −1.9 (2.7) cmH2O on placebo; p=0.049) but not passive Pcrit (−2.2 (3.4) versus −0.7 (2.1) cmH2O; p=0.135). A greater reduction in AHI occurred in those with minimal muscle compensation (defined as V′0,active−V′0, passive) on placebo (r=0.71, p=0.009). The reduction in AHI was driven by the improvement in muscle compensation (r=0.72, p=0.009). In OSA patients, noradrenergic stimulation with desipramine improves pharyngeal collapsibility and may be an effective treatment in patients with minimal upper airway muscle compensation. PMID:27799387

Pediatric autopsy case of asphyxia due to salmon egg (ikura) aspiration.

PubMed

Takamiya, Masataka; Niitsu, Hisae; Saigusa, Kiyoshi; Dewa, Koji

2016-09-01

Here we report an autopsy case of asphyxia due to aspiration of a salmon egg (ikura) into the airway. The patient was a 19-month-old girl. During breakfast, she put salmon eggs into her mouth, and began to walk. She slipped, fell down, and collapsed. She was pronounced dead following 2 h of resuscitation. The body was autopsied 28 h after death. The gastric contents consisted of rice, orange sections, and white salmon eggs. The lungs were deeply congested and over-inflated. In the right lung, areas of atelectasis in the upper and middle lobes were seen. A yellow salmon egg (8 mm in diameter) was found in the trachea. Although fish eggs are consumed throughout the world, reports of this sort are limited. The aspiration of fish eggs is under-acknowledged and underreported. The importance of preventive measures needs to be emphasized to parents and caregivers. © 2016 Japan Pediatric Society.

Video-assisted thoracoscopic surgery (VATS) right upper lobectomy for non-small-cell lung cancer with an azygos lobe

PubMed Central

Samancilar, Ozgur; Kaya, Seyda Ors; Sevinc, Serpil; Akcay, Onur; Ceylan, Kenan Can

2016-01-01

Although it is not a pathologically significant entity, cases of azygos lobe (AL) are interesting due to the difficulty of performing video-assisted thoracoscopic surgery (VATS) procedures in the affected patients and the presence of a congenital malformation. Currently, videothoracoscopic surgery has advanced to such a level that most thoracic procedures can be performed with video assistance. However, some technical difficulties may arise in cases with anatomical anomalies such as AL. This report presents the case of a patient with an azygos lobe who underwent videothoracoscopic lung resection due to the presence of non-small-cell lung carcinoma in the upper lobe of the right lung. PMID:28096840

Drained Lava Tubes and Lobes From Eocretaceous Paraná-Etendeka Province, Brazil

NASA Astrophysics Data System (ADS)

Waichel, B. L.; Lima, E. F. D.; Mouro, L. D.; Briske, D. R.; Tratz, E. B.

2017-12-01

The identification of lava tubes in continental flood basalt provinces (CFBP) is difficult and reports of preserved drained tubes and lobes are rare. The large extension of CFBP must be related to an efficient transport of lava and tubes are the most efficient mechanism to transport lava in insulated pathways, like observed in modern volcanic fields. Looking for caves in the central portion of Paraná-Etendeka Province, we discovered drained lava tubes (4) and lobes (6) in a volcanic sequence constituted by pahoehoe flows. Lava tubes are: Casa de Pedra, Perau Branco, Dal Pae and Pinhão. The Casa de Pedra tube system is composed of two principal chambers with similar dimensions, reaching up to 10 m long and 4.0 m high connected by a narrow passage. The general form of the chamber is hemispherical, with re-entrances of ellipsoidal shape probably formed by small lava lobes and collapse structures in the roof. The second chamber is connected with three secondary lava tubes. Columns in the cave are formed when the flowing lava separates in two lava channels that join again further down the system, forming and anastomosing tube network. Lateral lava benches and lava drainings at the walls are observed in secondary tubes. The general lava flow is to SW. The Perau Branco system is composed of five tubes with ellipsoidal openings. The main features are the long tubes that emerge from the small flattened chambers. One tube is more than 20 m long, with alternating circular and flattened ellipsoidal sections. The general lava flow is to NE. Pinhão tube is spherical with 3 meters diameter and 15 m long, with lava flow orientation to NW. This tube has a bottleneck shape with linings (up to 3 cm thick), which are observed in the roof and walls. Dal Pae Tube is 10 m long with an ellipsoidal opening, bottleneck shape and orientation to NE. The lava flow directions measured in the tubes is to SW (Casa de Pedra, Pinhão) and NE (Perau Branco, Dal Pae) and this pattern is related to orientation of the Ponta Grossa swarm feeder dikes (NW). The drained lava lobes show variable dimensions, typical lobate morphology and form sub-crustal caves. The smaller are up to 1.5 m high, 10 m wide and 15 long; the majors are up to 6m high, 20 m wide and 25 m long. Collapsed roofs are observed in big caves and collapses of overlying thin pahoehoe lobes are common in smaller lobes.

Therapeutic CPAP Level Predicts Upper Airway Collapsibility in Patients With Obstructive Sleep Apnea.

PubMed

Landry, Shane A; Joosten, Simon A; Eckert, Danny J; Jordan, Amy S; Sands, Scott A; White, David P; Malhotra, Atul; Wellman, Andrew; Hamilton, Garun S; Edwards, Bradley A

2017-06-01

Upper airway collapsibility is a key determinant of obstructive sleep apnea (OSA) which can influence the efficacy of certain non-continuous positive airway pressure (CPAP) treatments for OSA. However, there is no simple way to measure this variable clinically. The present study aimed to develop a clinically implementable tool to evaluate the collapsibility of a patient's upper airway. Collapsibility, as characterized by the passive pharyngeal critical closing pressure (Pcrit), was measured in 46 patients with OSA. Associations were investigated between Pcrit and data extracted from patient history and routine polysomnography, including CPAP titration. Therapeutic CPAP level, demonstrated the strongest relationship to Pcrit (r2=0.51, p < .001) of all the variables investigated including apnea-hypopnea index, body mass index, sex, and age. Patients with a mildly collapsible upper airway (Pcrit ≤ -2 cmH2O) had a lower therapeutic CPAP level (6.2 ± 0.6 vs. 10.3 ± 0.4 cmH2O, p < .001) compared to patients with more severe collapsibility (Pcrit > -2 cmH2O). A therapeutic CPAP level ≤8.0 cmH2O was sensitive (89%) and specific (84%) for detecting a mildly collapsible upper airway. When applied to the independent validation data set (n = 74), this threshold maintained high specificity (91%) but reduced sensitivity (75%). Our data demonstrate that a patient's therapeutic CPAP requirement shares a strong predictive relationship with their Pcrit and may be used to accurately differentiate OSA patients with mild airway collapsibility from those with moderate-to-severe collapsibility. Although this relationship needs to be confirmed prospectively, our findings may provide clinicians with better understanding of an individual patient's OSA phenotype, which ultimately could assist in determining which patients are most likely to respond to non-CPAP therapies. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

Multifocal synchronous ipsilateral Warthin tumors: case report and review of the literature.

PubMed

Hall, Joseph E; Statham, Melissa McCarty; Sheridan, Rachel M; Wilson, Keith M

2010-09-01

We report a case of a 73-year-old woman who presented with an enlarging superficial parotid mass, a concomitant ipsilateral deep-lobe parotid mass, and associated upper jugular lymphadenopathy. The clinical presentation and radiographic imaging were suggestive of malignancy, and the patient was treated with total parotidectomy with upper jugular lymph node sampling. Pathologic examination revealed two distinct masses, one in the superficial lobe and one in the deep lobe of the parotid gland, both consistent with synchronous Warthin tumors. Analysis of the upper jugular lymph nodes was consistent with reactive lymphoid hyperplasia. Although the true incidence of multicentricity in ipsilateral Warthin tumors may be underappreciated and underreported, this entity should remain in the differential diagnosis for unilateral parotid masses.

75 FR 61977 - Airworthiness Directives; The Boeing Company Model 747-100, 747-200B, and 747-200F Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... fatigue-related skin cracks and corrosion of the skin panel lap joints in the fuselage upper lobe, and... of corrosion, and related investigative and corrective actions. This AD reduces the maximum interval... and correct fatigue cracking and corrosion in the fuselage upper lobe skin lap joints, which could...

Lymph Node Metastases and Prognosis in Left Upper Division Non-Small Cell Lung Cancers: The Impact of Interlobar Lymph Node Metastasis

PubMed Central

Kuroda, Hiroaki; Sakao, Yukinori; Mun, Mingyon; Uehara, Hirofumi; Nakao, Masayuki; Matsuura, Yousuke; Mizuno, Tetsuya; Sakakura, Noriaki; Motoi, Noriko; Ishikawa, Yuichi; Yatabe, Yasushi; Nakagawa, Ken; Okumura, Sakae

2015-01-01

Background Left upper division segmentectomy is one of the major pulmonary procedures; however, it is sometimes difficult to completely dissect interlobar lymph nodes. We attempted to clarify the prognostic importance of hilar and mediastinal nodes, especially of interlobar lymph nodes, in patients with primary non-small cell lung cancer (NSCLC) located in the left upper division. Methods We retrospectively studied patients with primary left upper lobe NSCLC undergoing surgical pulmonary resection (at least lobectomy) with radical lymphadenectomy. The representative evaluation of therapeutic value from the lymph node dissection was determined using Sasako’s method. This analysis was calculated by multiplying the frequency of metastasis to the station and the 5-year survival rate of the patients with metastasis to the station. Results We enrolled 417 patients (237 men, 180 women). Tumors were located in the lingular lobe and at the upper division of left upper lobe in 69 and 348 patients, respectively. The pathological nodal statuses were pN0 in 263 patients, pN1 in 70 patients, and pN2 in 84 patients. Lymph nodes #11 and #7 were significantly correlated with differences in node involvement in patients with left upper lobe NSCLC. Among those with left upper division NSCLC, the 5-year overall survival in pN1 was 31.5% for #10, 39.3% for #11, and 50.4% for #12U. The involvement of node #11 was 1.89-fold higher in the anterior segment than that in the apicoposterior segment. The therapeutic index of estimated benefit from lymph node dissection for #11 was 3.38, #4L was 1.93, and the aortopulmonary window was 4.86 in primary left upper division NSCLC. Conclusions Interlobar node involvement is not rare in left upper division NSCLC, occurring in >20% cases. Furthermore, dissection of interlobar nodes was found to be beneficial in patients with left upper division NSCLC. PMID:26247881

Reconstructing Deep-Marine Sediment Gravity Flow Dynamics from Ancient Rocks: an Example from Skoorsteenberg Fm. Tanqua Karoo

NASA Astrophysics Data System (ADS)

Kane, I. A.; Pontén, A. S. M.; Hodgson, D.; Vangdal, B.

2015-12-01

The processes which create deep-marine lobes are challenging to study, owing to the depth of the lobes beneath the sea surface and the destructive nature of the sediment gravity flows which transport the sediment that builds them. One approach is to reconstruct paleohydraulics using detailed outcrop observations which can be used to build a theoretical framework for flow behavior. The Skoorsteenberg Fm., Tanqua Karoo, offers an excellent opportunity to study fine-grained deep-marine lobes in near continuous quasi-3D exposure. The spatial and stratigraphic distribution of the various facies of Fan 3 (one of the Skoorsteenberg Fm. lobe complexes) are presented. The turbidites which dominate the proximal and medial lobe areas, pass down-dip into very muddy sandstones which are here attributed to a type of transitional flow state. The model developed here suggests that turbidity currents exiting channels were large and turbulent enough to erode and entrain their substrate, increasing their concentration and clay content. As the flows decelerated they became increasingly stratified, characterised by an increasing bulk Richardson (Ri). Sand and silt particles settled together with flocculated clay, forming a cohesive, low yield-strength layer. This layer flowed in a laminar manner but settling of sand grains continued due to the low yield strength. The rising yield strength of the lower layer progressively inhibited the efficiency of vertical mixing, characterised by an increasing flux Richardson number, which, when it exceeded a critical value , led to a catastrophic collapse of the turbulent energy field and en-masse transformation of the upper part of the flow, ultimately resulting in a highly argillaceous sandstone (debrite) division. This transformation was possible due to the narrow grain size range, dominantly silt-vf sand with abundant flocculated clay, which behaved as a single phase. This model of flow evolution accounts for the presence of such beds without invoking external controls or large-scale flow partitioning, and also explains the abrupt pinchout of all divisions of these sandstones following catastrophic loss of turbulence.

East Candor Chasma

NASA Technical Reports Server (NTRS)

1997-01-01

During its examination of Mars, the Viking 1 spacecraft returned images of Valles Marineris, a huge canyon system 5,000 km long, up to 240 km wide, and 6.5 km deep, whose connected chasma or valleys may have formed from a combination of erosional collapse and structural activity. The view shows east Candor Chasma, one of the connected valleys of Valles Marineris; north toward top of frame; for scale, the impact crater in upper right corner is 15 km (9 miles) wide. The image, centered at latitude 7.5 degrees S., longitude 67.5 degrees, is a composite of Viking 1 Orbiter high-resolution (about 80 m/pixel or picture element) images in black and white and low-resolution (about 250 m/pixel) images in color. The Viking 1 craft landed on Mars in July of 1976.

East Candor Chasma occupies the eastern part of the large west-northwest-trending trough of Candor Chasma. This section is about 150 km wide. East Candor Chasma is bordered on the north and south by walled cliffs, most likely faults. The walls may have been dissected by landslides forming reentrants; one area on the north wall shows what appears to be landslide debris. Both walls show spur-and-gully morphology and smooth sections. In the lower part of the image northwest-trending, linear depressions on the plateau are younger graben or fault valleys that cut the south wall.

Material central to the chasma shows layering in places and has been locally eroded by the wind to form flutes and ridges. These interior layered deposits have curvilinear reentrants carved into them, and in one locale a lobe flows away from the top of the interior deposit. The lobe may be mass-wasting deposits due to collapse of older interior deposits (Lucchitta, 1996, LPSC XXVII abs., p. 779- 780); this controversial idea requires that the older layered deposits were saturated with ice, perhaps from former lakes, and that young volcanism and/or tectonism melted the ice and made the material flow.

Upper Airway Collapsibility (Pcrit) and Pharyngeal Dilator Muscle Activity are Sleep Stage Dependent

PubMed Central

Carberry, Jayne C.; Jordan, Amy S.; White, David P.; Wellman, Andrew; Eckert, Danny J.

2016-01-01

Study Objectives: An anatomically narrow/highly collapsible upper airway is the main cause of obstructive sleep apnea (OSA). Upper airway muscle activity contributes to airway patency and, like apnea severity, can be sleep stage dependent. Conversely, existing data derived from a small number of participants suggest that upper airway collapsibility, measured by the passive pharyngeal critical closing pressure (Pcrit) technique, is not sleep stage dependent. This study aimed to determine the effect of sleep stage on Pcrit and upper airway muscle activity in a larger cohort than previously tested. Methods: Pcrit and/or muscle data were obtained from 72 adults aged 20–64 y with and without OSA.Pcrit was determined via transient reductions in continuous positive airway pressure (CPAP) during N2, slow wave sleep (SWS) and rapid eye movement (REM) sleep. Genioglossus and tensor palatini muscle activities were measured: (1) awake with and without CPAP, (2) during stable sleep on CPAP, and (3) in response to the CPAP reductions used to quantify Pcrit. Results: Pcrit was 4.9 ± 1.4 cmH2O higher (more collapsible) during REM versus SWS (P = 0.012), 2.3 ± 0.6 cmH2O higher during REM versus N2 (P < 0.001), and 1.6 ± 0.7 cmH2O higher in N2 versus SWS (P = 0.048). Muscle activity decreased from wakefulness to sleep and from SWS to N2 to REM sleep for genioglossus but not for tensor palatini. Pharyngeal muscle activity increased by ∼50% by breath 5 following CPAP reductions. Conclusions: Upper airway collapsibility measured via the Pcrit technique and genioglossus muscle activity vary with sleep stage. These findings should be taken into account when performing and interpreting “passive” Pcrit measurements. Citation: Carberry JC, Jordan AS, White DP, Wellman A, Eckert DJ. Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent. SLEEP 2016;39(3):511–521. PMID:26612386

Pleuroparenchymal fibroelastosis: report of two cases in Brazil.

PubMed

Gomes, Paula Silva; Shiang, Christina; Szarf, Gilberto; Coletta, Ester Nei Aparecida Martins; Pereira, Carlos Alberto de Castro

2017-01-01

Pleuroparenchymal fibroelastosis (PPFE) is a rare lung disease. It can be idiopathic or associated with any one of various conditions. To our knowledge, this is the first report of two cases of PPFE in Brazil. Our first patient presented with pleural and subpleural fibrosis in the upper lobes; a spiculated nodule in the left upper lobe; and a mild reticular pattern in the lower lobes. Surgical lung biopsy revealed PPFE in the upper lobes, including the nodule, and unclassified interstitial pneumonia in the left lower lobe. Our second patient had a history of exposure to domestic birds, indicating a risk of hypersensitivity pneumonitis, and presented with advanced lung disease, predominantly in the upper lobes, together with subpleural fibrosis.That patient underwent lung transplantation. In the explant specimen, PPFE and granulomas were identified, suggesting hypersensitivity pneumonitis as an associated cause. RESUMO A fibroelastose pleuroparenquimatosa (FEPP) é uma doença pulmonar rara, podendo ser idiopática ou associada a diversas condições. Pelo que sabemos, este é o primeiro relato de dois casos de FEPP no Brasil. Nosso primeiro paciente apresentava fibrose pleural e subpleural nos lobos superiores, um nódulo espiculado no lobo superior esquerdo e um padrão reticular discreto nos lobos inferiores. A biópsia pulmonar cirúrgica demonstrou FEPP nos lobos superiores, incluindo no nódulo, e pneumonia intersticial não classificada no lobo inferior esquerdo. Nosso segundo paciente tinha história de exposição a aves domésticas, indicando um risco de pneumonite de hipersensibilidade, e doença pulmonar avançada predominando em lobos superiores, com fibrose subpleural. Esse paciente foi submetido a transplante pulmonar. No espécime do explante, FEPP e granulomas foram identificados, sugerindo pneumonite de hipersensibilidade como causa associada.

Subcarinal lymph node in upper lobe non-small cell lung cancer patients: is selective lymph node dissection valid?

PubMed

Aokage, Keiju; Yoshida, Junji; Ishii, Genichiro; Hishida, Tomoyuki; Nishimura, Mitsuyo; Nagai, Kanji

2010-11-01

Little is known about selective lymph node dissection in non-small cell lung cancer (NSCLC) patients. We sought to gain insight into subcarinal node involvement for its frequency and impact on outcome to evaluate whether it is valid to omit subcarinal lymph node dissection in upper lobe NSCLC patients. We reviewed node metastases distribution according to node region, tumor location, and histology among 1099 patients with upper lobe NSCLC. We paid special attention to subcarinal metastases patients without superior mediastinal node metastases, because their pathological stages would have been underdiagnosed if subcarinal node dissection had been omitted. We also assessed the outcome and the pattern of failure among subcarinal metastases patients. To identify subcarinal node involvement predictors, we analyzed 7 clinical factors. Subcarinal node metastases were found in 20 patients and were least frequent among squamous cell carcinoma patients (0.5%). Two of them were free from superior mediastinal metastases but died of the disease at 1 month and due to an unknown cause at 18 months, respectively. Seventeen of the 20 patients developed multi-site recurrence within 37 months. The 5-year survival rate of the 20 patients with subcarinal metastases was 9.0%, which was significantly lower than 32.0% of patients with only superior mediastinal metastases. Clinical diagnosis of node metastases was significantly predictive of subcarinal metastases. Subcarinal node metastases from upper lobe NSCLC were rare and predicted an extremely poor outcome. It appears valid to omit subcarinal node dissection in upper lobe NSCLC patients, especially in clinical N0 squamous cell carcinoma patients. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

A precocious adult visual center in the larva defines the unique optic lobe of the split-eyed whirligig beetle Dineutus sublineatus

PubMed Central

2013-01-01

Introduction Whirligig beetles (Coleoptera: Gyrinidae) are aquatic insects living on the water surface. They are equipped with four compound eyes, an upper pair viewing above the water surface and a lower submerged pair viewing beneath the water surface, but little is known about how their visual brain centers (optic lobes) are organized to serve such unusual eyes. We show here, for the first time, the peculiar optic lobe organization of the larval and adult whirligig beetle Dineutus sublineatus. Results The divided compound eyes of adult whirligig beetles supply optic lobes that are split into two halves, an upper half and lower half, comprising an upper and lower lamina, an upper and lower medulla and a bilobed partially split lobula. However, the lobula plate, a neuropil that in flies is known to be involved in mediating stabilized flight, exists only in conjunction with the lower lobe of the lobula. We show that, as in another group of predatory beetle larvae, in the whirligig beetle the aquatic larva precociously develops a lobula plate equipped with wide-field neurons. It is supplied by three larval laminas serving the three dorsal larval stemmata, which are adjacent to the developing upper compound eye. Conclusions In adult whirligig beetles, dual optic neuropils serve the upper aerial eyes and the lower subaquatic eyes. The exception is the lobula plate. A lobula plate develops precociously in the larva where it is supplied by inputs from three larval stemmata that have a frontal-upper field of view, in which contrasting objects such as prey items trigger a body lunge and mandibular grasp. This precocious lobula plate is lost during pupal metamorphosis, whereas another lobula plate develops normally during metamorphosis and in the adult is associated with the lower eye. The different roles of the upper and lower lobula plates in supporting, respectively, larval predation and adult optokinetic balance are discussed. Precocious development of the upper lobula plate represents convergent evolution of an ambush hunting lifestyle, as exemplified by the terrestrial larvae of tiger beetles (Cicindelinae), in which activation of neurons in their precocious lobula plates, each serving two large larval stemmata, releases reflex body extension and mandibular grasp. PMID:23421712

[Prediction of the efficiency of endoscopic lung volume reduction by valves in severe emphysema].

PubMed

Bocquillon, V; Briault, A; Reymond, E; Arbib, F; Jankowski, A; Ferretti, G; Pison, C

2016-11-01

In severe emphysema, endoscopic lung volume reduction with valves is an alternative to surgery with less morbidity and mortality. In 2015, selection of patients who will respond to this technique is based on emphysema heterogeneity, a complete fissure visible on the CT-scan and absence of collateral ventilation between lobes. Our case report highlights that individualized prediction is possible. A 58-year-old woman had severe, disabling pulmonary emphysema. A high resolution thoracic computed tomography scan showed that the emphysema was heterogeneous, predominantly in the upper lobes, integrity of the left greater fissure and no collateral ventilation with the left lower lobe. A valve was inserted in the left upper lobe bronchus. At one year, clinical and functional benefits were significant with complete atelectasis of the treated lobe. The success of endoscopic lung volume reduction with a valve can be predicted, an example of personalized medicine. Copyright © 2016 SPLF. Published by Elsevier Masson SAS. All rights reserved.

Long-term Outcome of Short Metallic Stents for Lobar Airway Stenosis.

PubMed

Fruchter, Oren; Abed El Raouf, Bayya; Rosengarten, Dror; Kramer, Mordechai R

2017-07-01

Whereas stents are considered an excellent treatment for proximal central major airway stenosis, the value of stenting for distal lobar airway stenosis is still controversial. Our aim was to explore the short-term and long-term outcome of metallic stents placed for benign and malignant lobar airway stenosis. Between July 2007 and July 2014, 14 patients underwent small airway stent insertion. The clinical follow-up included serial semiannual physical examinations, pulmonary function tests, imaging, and bronchoscopy. The etiologies for airway stenosis were: early post-lung transplantation bronchial stenosis (N=5), sarcoidosis (N=1), amyloidosis (N=1), anthracofibrosis (N=1), right middle lobe syndrome due to external lymph node compression (N=1), lung cancer (N=4), and stenosis of the left upper lobe of unknown etiology (N=1). Stents were placed in the right upper lobe bronchus (N=2), right middle lobe bronchus (N=6), left upper lobe bronchus (N=4), linguar bronchus (N=1), and left lower lobe bronchus (N=1). The median follow-up period ranged from 2 to 72 months (median 18 mo). Immediate relief of symptoms was achieved in the vast majority of patients (13/14, 92%). Out of 10 patients with benign etiology for stenosis, 9 (90%) experienced sustained and progressive improvement in pulmonary function tests and clinical condition. We describe our positive experience with small stents for lobar airway stenosis; further prospective trials are required to evaluate the value of this novel modality of treatment.

[Thin-section computed tomography of the bronchi; 2. Right upper lobe and left upper division].

PubMed

Matsuoka, Y; Ookubo, T; Ohtomo, K; Nishikawa, J; Kojima, K; Oyama, K; Yoshikawa, K; Iio, M

1990-02-01

Thin (2mm) section contiguous computed tomographic (CT) scans were obtained through the bronchi of the right upper lobe and the left upper division in 30 patients. All segmental bronchi were identified. The right subsegmental bronchi were identified in 100%, and the left subsegmental bronchi in 97%. The type of the orifice of the right bronchus was trifurcated (53%), the extension of B1 was apicoanterior (50%), and the size of B2b was equal to B3a (63%). The extension of the left B3 was subapicoanterior (38%), and the size of B1+2c was equal to B3a (62%).

Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea

PubMed Central

Andara, Christopher; Landry, Shane; Sands, Scott A.; Joosten, Simon A.; Owens, Robert L.; White, David P.; Hamilton, Garun S.; Wellman, Andrew

2016-01-01

Rationale: Oral appliances (OAs) are commonly used as an alternative treatment to continuous positive airway pressure for patients with obstructive sleep apnea (OSA). However, OAs have variable success at reducing the apnea–hypopnea index (AHI), and predicting responders is challenging. Understanding this variability may lie with the recognition that OSA is a multifactorial disorder and that OAs may affect more than just upper-airway anatomy/collapsibility. Objectives: The objectives of this study were to determine how OA alters AHI and four phenotypic traits (upper-airway anatomy/collapsibility and muscle function, loop gain, and arousal threshold), and baseline predictors of which patients gain the greatest benefit from therapy. Methods: In a randomized crossover study, 14 patients with OSA attended two sleep studies with and without their OA. Under each condition, AHI and the phenotypic traits were assessed. Multiple linear regression was used to determine independent predictors of the reduction in AHI. Measurements and Main Results: OA therapy reduced the AHI (30 ± 5 vs. 11 ± 2 events/h; P < 0.05), which was driven by improvements in upper-airway anatomy/collapsibility under passive (1.9 ± 0.7 vs. 4.7 ± 0.6 L/min; P < 0.005) and active conditions (2.4 ± 0.9 vs. 6.2 ± 0.4 L/min; P < 0.001). No changes were seen in muscle function, loop gain, or the arousal threshold. Using multivariate analysis, baseline passive upper-airway collapsibility and loop gain were independent predictors of the reduction in AHI (r2 = 0.70; P = 0.001). Conclusions: Our findings suggest that OA therapy improves the upper-airway collapsibility under passive and active conditions. Importantly, a greater response to therapy occurred in those patients with a mild anatomic compromise and a lower loop gain. PMID:27181367

Differential diagnosis and cancer staging of a unique case with multiple nodules in the lung - lung adenocarcinoma, metastasis of colon adenocarcinoma, and colon adenocarcinoma metastasizing to lung adenocarcinoma.

PubMed

Bai, Yun; Qiu, Jianxing; Shang, Xueqian; Liu, Ping; Zhang, Ying; Wang, Ying; Xiong, Yan; Li, Ting

2015-05-01

Lung cancer is the most common cancer in the world. Despite this, there have been few cases of simultaneous primary and metastatic cancers in the lung reported, let alone coexisting with tumor-to-tumor metastasis. Herein, we describe an extremely unusual case. A 61-year-old man with a history of colon adenocarcinoma was revealed as having three nodules in the lung 11 months after colectomy. The nodule in the left upper lobe was primary lung adenocarcinoma, the larger one in the right upper lobe was a metastasis of colon adenocarcinoma, and the smaller one in the right upper lobe was colon adenocarcinoma metastasizing to lung adenocarcinoma. Our paper focused on the differential diagnosis and cancer staging of this unique case, and discussed the uncommon phenomenon of the lung acting as a recipient in tumor-to-tumor metastasis.

Dementia of frontal lobe type and motor neuron disease. A Golgi study of the frontal cortex.

PubMed Central

Ferrer, I; Roig, C; Espino, A; Peiro, G; Matias Guiu, X

1991-01-01

Neuropathological findings in a 38 year old patient with dementia of frontal lobe type and motor neuron disease included pyramidal tracts, myelin pallor and neuron loss, gliosis and chromatolysis in the hypoglossal nucleus, together with frontal atrophy, neuron loss, gliosis and spongiosis in the upper cortical layers of the frontal (and temporal) lobes. Most remaining pyramidal and non-pyramidal neurons (multipolar, bitufted and bipolar cells) in the upper layers (layers II and III) of the frontal cortex (area B) had reduced dendritic arbors, proximal dendritic varicosities and amputation of dendrites as revealed in optimally stained rapid Golgi sections. Pyramidal cells in these layers also showed depletion of dendritic spines. Neurons in the inner layers were preserved. Loss of receptive surfaces in neurons of the upper cortical layers in the frontal cortex are indicative of neuronal disconnection, and are "hidden" contributory morphological substrates for the development of dementia. Images PMID:1744652

SU-E-J-18: Evaluation of the Effectiveness of Compression Methods in SBRT for Lung.

PubMed

Liao, Y; Tolekids, G; Yao, R; Templeton, A; Sensakovic, W; Chu, J

2012-06-01

This study aims to evaluate the effectiveness of compression in immobilizing tumor during stereotactic body radiotherapy (SBRT) for lung cancer. Published data have demonstrated bigger respiratory motion in lower lobe than in upper lobe during normal breathing. We hypothesize that 4DCT-based patient selection and abdominal compression would immobilize lung tumor volumes effectively, regardless of their location. We retrospectively reviewed 12 SBRT lung cases treated with Trilogy® (Varian Medical System, Palo Alto, CA). Either compression plate or Vac-LokTM was used as abdomen compression of the SBRT immobilization system (Body Pro-LokTM, CIVCO) to restrict patients' breathing during CT simulation and treatment delivery. These cases are grouped into 2 categories: lower and upper lobe tumor, each with 6 cases. Records for 33 treatments were studied. On each treatment day, the patient was set up to the bony anatomy using kV-kV-match. A CBCT was performed to further set up the patient to the tumor based on the soft tissue information. The shifts from CBCT-setup were analyzed as displacement vectors demonstrating the magnitude of the tumor motion relative to the bony anatomy. The mean magnitude of displacement vectors for upper lobe and lower lobe were 3.7±2.7 and 4.2±6.3, [1S.D.] mm, respectively. The Wilcoxon rank sum test indicates that the difference in the displacement vector between the two groups is not statistically significant (p-value = 0.33). The magnitude of shifts from CBCT were small with mean value <5mm in SBRT lung treatments. No statistically significant difference were observed in the displacement of tumor between lower and upper lobes. With limited sample size, this suggests that our current 4DCT screening/abdominal compression approach is effective in restricting the respiration-induced tumor motion despite its location within the lung. We plan to confirm this Result in additional patients. © 2012 American Association of Physicists in Medicine.

[The effect of pre-surgical orthodontics on secondary alveolar bone grafting in the patients with complete cleft lip and palate].

PubMed

Jia, Yi-lin; Fu, Min-kui; Ma, Lian

2004-05-01

To examine the effect of pre-surgical orthodontics on the outcome of the secondary alveolar bone grafting in the patients with complete cleft lip and palate. Sixteen complete cleft lip and palate patients (9 males and 7 females) with collapsed upper arch or severe mal-positioned upper incisors were selected. The cleft was not easily grafted because of the poor access. The total cleft sites were 22 (10 patients with UCLP and 6 patients with BCLP). The age range of the patients was from 8 to 22 years. Pre-surgical orthodontic treatment was mainly to expand the collapsed upper arch and correct the mal-positioned upper incisors. After the secondary alveolar bone grafting, the patients were followed up and anterior occlusal radiograph/intraoral panograph were taken regularly. The observation period was from 6 months to 4 years. Bergland criteria were used to evaluate the interdental septal height. Upper arch expansion and the correction of the mal-positioned upper incisors done by the orthodontic treatment made the bone grafting procedure easier. The clinically successful rate reached 86%. The severe upper arch collapse and mal-positioned upper incisors in the patients with complete cleft lip and palate should be corrected orthodontically before the secondary alveolar bone grafting.

Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group.

PubMed

Naunheim, Keith S; Wood, Douglas E; Mohsenifar, Zab; Sternberg, Alice L; Criner, Gerard J; DeCamp, Malcolm M; Deschamps, Claude C; Martinez, Fernando J; Sciurba, Frank C; Tonascia, James; Fishman, Alfred P

2006-08-01

The National Emphysema Treatment Trial defined subgroups of patients with severe emphysema in whom lung-volume-reduction surgery (LVRS) improved survival and function at 2 years. Two additional years of follow-up provide valuable information regarding durability. A total of 1218 patients with severe emphysema were randomized to receive LVRS or medical treatment. We present updated analyses (4.3 versus 2.4 years median follow-up), including 40% more patients with functional measures 2 years after randomization. The intention-to-treat analysis of 1218 randomized patients demonstrates an overall survival advantage for LVRS, with a 5-year risk ratio (RR) for death of 0.86 (p = 0.02). Improvement was more likely in the LVRS than in the medical group for maximal exercise through 3 years and for health-related quality of life (St. George's Respiratory Questionnaire [SGRQ]) through 4 years. Updated comparisons of survival and functional improvement were consistent with initial results for four clinical subgroups of non-high-risk patients defined by upper-lobe predominance and exercise capacity. After LVRS, the upper-lobe patients with low exercise capacity demonstrated improved survival (5-year RR, 0.67; p = 0.003), exercise throughout 3 years (p < 0.001), and symptoms (SGRQ) through 5 years (p < 0.001 years 1 to 3, p = 0.01 year 5). Upper-lobe-predominant and high-exercise-capacity LVRS patients obtained no survival advantage but were likely to improve exercise capacity (p < 0.01 years 1 to 3) and SGRQ (p < 0.01 years 1 to 4). Effects of LVRS are durable, and it can be recommended for upper-lobe-predominant emphysema patients with low exercise capacity and should be considered for palliation in patients with upper-lobe emphysema and high exercise capacity.

Exercising videoendoscopic evaluation of 45 horses with respiratory noise and/or poor performance after laryngoplasty.

PubMed

Davidson, Elizabeth J; Martin, Benson B; Rieger, Randall H; Parente, Eric J

2010-12-01

To (1) assess upper airway function by videoendoscopy in horses performing poorly after laryngoplasty and (2) establish whether dynamic collapse of the left arytenoid can be predicted by the degree of resting postsurgical abduction. Case series. Horses that had left laryngoplasty (n=45). Medical records (June 1993-December 2007) of horses evaluated for abnormal respiratory noise and/or poor performance after laryngoplasty were reviewed. Horses with video recordings of resting and exercising upper airway endoscopy were included and postsurgical abduction categorized. Horses with immediate postoperative endoscopy recordings were also evaluated and postsurgical abduction categorized. Relationships between resting postsurgical abduction and historical information with exercising endoscopic findings were examined. Dynamic collapse of the left arytenoid cartilage was probable in horses with no postsurgical abduction and could not be predicted in horses with grade 3 or 4 postsurgical abduction. Respiratory noise was associated with upper airway obstruction but was not specific for arytenoid collapse. Most horses with a left vocal fold had billowing of the fold during exercise. Other forms of dynamic collapse involved the right vocal fold, aryepiglottic folds, corniculate process of left arytenoid cartilage, dorsal displacement of soft palate, and pharyngeal collapse. Complex obstructions were observed in most examinations and in all horses with exercising collapse of the left arytenoid cartilage. There was no relationship between exercising collapse of the left arytenoid cartilage and grade 3 or 4 postsurgical abduction but was likely in horses with no abduction. © Copyright 2010 by The American College of Veterinary Surgeons.

Geological constraints of a structural model of sector collapse at Stromboli volcano, Italy

NASA Astrophysics Data System (ADS)

Vezzoli, L.; Corazzato, C.

2016-09-01

This study is focused on the reconstruction of the structure and dynamics of the first lateral collapse that occurred at Stromboli during the Holocene, which represents the structure inherited by all the following collapses that formed the present Sciara del Fuoco depression. The first lateral collapse of Stromboli occurred at the end of the Vancori volcano activity, at about 13 ka ago. The Neostromboli lava cone grew within this collapse amphitheater. Based on a comprehensive geologic and structural analysis of both Vancori and Neostromboli products, we propose an innovative interpretation of the sliding surface. Once considered to be a homogeneous landslide along a deep-seated sliding surface, we demonstrate that the Upper Vancori failure was accommodated by a more complex deformation regime comprising an upper (proximal) domain of tilted megablocks (toreva) and a lower (distal) domain of fragmental landslide transport and deposition.

Positive pressure ventilation in a patient with a right upper lobar bronchocutaneous fistula: right upper bronchus occlusion using the cuff of a left-sided double lumen endobronchial tube.

PubMed

Omori, Chieko; Toyama, Hiroaki; Takei, Yusuke; Ejima, Yutaka; Yamauchi, Masanori

2017-08-01

In patients with a bronchocutaneous fistula, positive pressure ventilation leads to air leakage and potential hypoxemia. A male patient with a right upper bronchocutaneous fistula was scheduled for esophageal reconstruction. His preoperative chest computed tomography image revealed aeration in the right middle and lower lobe, a large bulla in the left upper lobe, and pleural effusion and pneumonia in the left lower lobe. Therefore, left one-lung ventilation was considered to result in hypoxemia. Before anesthesia induction, the bronchocutaneous fistula was covered with gauze and film to prevent air leakage. After anesthesia induction, mask ventilation was performed with a peak positive pressure of 10 cmH 2 O. A left-sided double lumen endobronchial tube (DLT) was then inserted into the right main bronchus for occluding only the right superior bronchus, and two-lung ventilation was performed to minimize airway pressure and maintain oxygenation, which did not cause air leakage through the fistula. During anesthesia, no ventilation-related difficulty was faced. The method of inserting a left-sided DLT into the right main bronchus and occluding the right upper bronchus selectively by bronchial cuff is considered to be an option for mechanical ventilation in patients with a right upper bronchial fistula, as demonstrated in the present case.

Automated lobar quantification of emphysema in patients with severe COPD.

PubMed

Revel, Marie-Pierre; Faivre, Jean-Baptiste; Remy-Jardin, Martine; Deken, Valérie; Duhamel, Alain; Marquette, Charles-Hugo; Tacelli, Nunzia; Bakai, Anne-Marie; Remy, Jacques

2008-12-01

Automated lobar quantification of emphysema has not yet been evaluated. Unenhanced 64-slice MDCT was performed in 47 patients evaluated before bronchoscopic lung-volume reduction. CT images reconstructed with a standard (B20) and high-frequency (B50) kernel were analyzed using a dedicated prototype software (MevisPULMO) allowing lobar quantification of emphysema extent. Lobar quantification was obtained following (a) a fully automatic delineation of the lobar limits by the software and (b) a semiautomatic delineation with manual correction of the lobar limits when necessary and was compared with the visual scoring of emphysema severity per lobe. No statistically significant difference existed between automated and semiautomated lobar quantification (p > 0.05 in the five lobes), with differences ranging from 0.4 to 3.9%. The agreement between the two methods (intraclass correlation coefficient, ICC) was excellent for left upper lobe (ICC = 0.94), left lower lobe (ICC = 0.98), and right lower lobe (ICC = 0.80). The agreement was good for right upper lobe (ICC = 0.68) and moderate for middle lobe (IC = 0.53). The Bland and Altman plots confirmed these results. A good agreement was observed between the software and visually assessed lobar predominance of emphysema (kappa 0.78; 95% CI 0.64-0.92). Automated and semiautomated lobar quantifications of emphysema are concordant and show good agreement with visual scoring.

Effects of magnetospheric lobe cell convection on dayside upper thermospheric winds at high latitudes

NASA Astrophysics Data System (ADS)

Zhang, B.; Wang, W.; Wu, Q.; Knipp, D.; Kilcommons, L.; Brambles, O. J.; Liu, J.; Wiltberger, M.; Lyon, J. G.; Häggström, I.

2016-08-01

This paper investigates a possible physical mechanism of the observed dayside high-latitude upper thermospheric wind using numerical simulations from the coupled magnetosphere-ionosphere-thermosphere (CMIT) model. Results show that the CMIT model is capable of reproducing the unexpected afternoon equatorward winds in the upper thermosphere observed by the High altitude Interferometer WIND observation (HIWIND) balloon. Models that lack adequate coupling produce poleward winds. The modeling study suggests that ion drag driven by magnetospheric lobe cell convection is another possible mechanism for turning the climatologically expected dayside poleward winds to the observed equatorward direction. The simulation results are validated by HIWIND, European Incoherent Scatter, and Defense Meteorological Satellite Program. The results suggest a strong momentum coupling between high-latitude ionospheric plasma circulation and thermospheric neutral winds in the summer hemisphere during positive IMF Bz periods, through the formation of magnetospheric lobe cell convection driven by persistent positive IMF By. The CMIT simulation adds important insight into the role of dayside coupling during intervals of otherwise quiet geomagnetic activity

No air leak on PPV does not exclude tracheobronchial injury after blunt chest trauma.

PubMed

Ong, Victor Yeok Kein; Tan, Kenneth Hock Soon

2008-04-01

Tracheobronchial injuries are commonly associated with persistent air leak with pneumothoraces especially when on positive pressure ventilation (PPV). Injuries with absence of these features together with collapse of the lung and consequent low arterial oxygen tension while on PPV are less well recognised. We present a patient with traumatic aortic dissection and preoperatively undiagnosed complete transaction of the left main bronchus following blunt chest trauma. He had no persistent air leak with lower lung lobe collapse despite undergoing PPV and had low arterial oxygen tension which failed to respond to appropriate oxygen therapy.

Fermi-LAT and Suzaku Observations of the Radio Galaxy Centaurus B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katsuta, Junichiro; /Stanford U., HEPL /KIPAC, Menlo Park; Tanaka, Y.T.

2012-08-17

CentaurusB is a nearby radio galaxy positioned in the Southern hemisphere close to the Galactic plane. Here we present a detailed analysis of about 43 months accumulation of Fermi-LAT data and of newly acquired Suzaku X-ray data for Centaurus B. The source is detected at GeV photon energies, although we cannot completely exclude the possibility that it is an artifact due to incorrect modeling of the bright Galactic diffuse emission in the region. The LAT image provides a weak hint of a spatial extension of the {gamma} rays along the radio lobes, which is consistent with the lack of sourcemore » variability in the GeV range. We note that the extension cannot be established statistically due to the low number of the photons. Surprisingly, we do not detect any diffuse emission of the lobes at X-ray frequencies, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. The broad-band modeling shows that the observed {gamma}-ray flux of the source may be produced within the lobes, if the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. This association would imply that efficient in-situ acceleration of the ultrarelativistic particles is occurring and that the lobes are dominated by the pressure from the relativistic particles. However, if the diffuse X-ray emission is much below the Suzaku upper limits, the observed {gamma}-ray flux is not likely to be produced within the lobes, but instead within the unresolved core of Centaurus B. In this case, the extended lobes could be dominated by the pressure of the magnetic field.« less

East Candor Chasma

NASA Image and Video Library

1998-06-08

During its examination of Mars, NASA's Viking 1 spacecraft returned images of Valles Marineris, a huge canyon system 5,000 km long, up to 240 km wide, and 6.5 km deep, whose connected chasma or valleys may have formed from a combination of erosional collapse and structural activity. The view shows east Candor Chasma, one of the connected valleys of Valles Marineris; north toward top of frame; for scale, the impact crater in upper right corner is 15 km (9 miles) wide. The image, centered at latitude 7.5 degrees S., longitude 67.5 degrees, is a composite of Viking 1 Orbiter high-resolution (about 80 m/pixel or picture element) images in black and white and low-resolution (about 250 m/pixel) images in color. The Viking 1 craft landed on Mars in July of 1976. East Candor Chasma occupies the eastern part of the large west-northwest-trending trough of Candor Chasma. This section is about 150 km wide. East Candor Chasma is bordered on the north and south by walled cliffs, most likely faults. The walls may have been dissected by landslides forming reentrants; one area on the north wall shows what appears to be landslide debris. Both walls show spur-and-gully morphology and smooth sections. In the lower part of the image northwest-trending, linear depressions on the plateau are younger graben or fault valleys that cut the south wall. Material central to the chasma shows layering in places and has been locally eroded by the wind to form flutes and ridges. These interior layered deposits have curvilinear reentrants carved into them, and in one locale a lobe flows away from the top of the interior deposit. The lobe may be mass-wasting deposits due to collapse of older interior deposits (Lucchitta, 1996, LPSC XXVII abs., p. 779- 780); this controversial idea requires that the older layered deposits were saturated with ice, perhaps from former lakes, and that young volcanism and/or tectonism melted the ice and made the material flow. http://photojournal.jpl.nasa.gov/catalog/PIA00424

SU-E-J-90: Lobar-Level Lung Ventilation Analysis Using 4DCT and Deformable Image Registration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Du, K; Bayouth, J; Patton, T

2015-06-15

Purpose: To assess regional changes in human lung ventilation and mechanics using four-dimensional computed tomography (4DCT) and deformable image registration. This work extends our prior analysis of the entire lung to a lobe-based analysis. Methods: 4DCT images acquired from 20 patients prior to radiation therapy (RT) were used for this analysis. Jacobian ventilation and motion maps were computed from the displacement field after deformable image registration between the end of expiration breathing phase and the end of inspiration breathing phase. The lobes were manually segmented on the reference phase by a medical physicist expert. The voxel-by-voxel ventilation and motion magnitudemore » for all subjects were grouped by lobes and plotted into cumulative voxel frequency curves respectively. In addition, to eliminate the effect of different breathing efforts across subjects, we applied the inter-subject equivalent lung volume (ELV) method on a subset of the cohort and reevaluated the lobar ventilation. Results: 95% of voxels in the lung are expanding during inspiration. However, some local regions of lung tissue show far more expansion than others. The greatest expansion with respiration occurs within the lower lobes; between exhale and inhale the median expansion in lower lobes is approximately 15%, while the median expansion in upper lobes is 10%. This appears to be driven by a subset of lung tissues within the lobe that have greater expansion; twice the number of voxels in the lower lobes (20%) expand by > 30% when compared to the upper lobes (10%). Conclusion: Lung ventilation and motion show significant difference on the lobar level. There are different lobar fractions of driving voxels that contribute to the major expansion of the lung. This work was supported by NIH grant CA166703.« less

Basics of Postural Drainage and Percussion

MedlinePlus

... the collarbone and the top of the shoulder blade. Repeat on the opposite site. Your child can ... the collarbone and the top of the shoulder blade. Upper Back Chest -- Upper Lobes Have your child ...

Causes of complexity in a fallout dominated plinian eruption sequence: 312 ka Fasnia Member, Diego Hernández Formation, Tenerife, Spain

NASA Astrophysics Data System (ADS)

Edgar, C. J.; Cas, R. A. F.; Olin, P. H.; Wolff, J. A.; Martí, J.; Simmons, J. M.

2017-10-01

The 312 ka Fasnia eruption from the Las Cañadas Caldera on Tenerife, Canary Islands, Spain, produced a complex sequence of twenty-two intercalated units, including 7 pumice fall, 7 ignimbrite and 8 ash surge and fall deposits that define two distinct eruption sequences (Lower and Upper Fasnia sequences). The fallout units themselves are internally complex, reflecting waxing and waning of the eruption column, while many of the ignimbrites reflect multiple intra-plinian partial column collapse events associated with the injection of lithic clasts into the eruption column. The Lower and Upper Fasnia eruption phases were each terminated by caldera collapse and complete column collapse events. Probable blockage of the conduit and vent system during Lower Fasnia caldera collapse event briefly terminated the eruption, resulting in a short-lived period of erosion and sedimentation prior to the onset of the Upper Fasnia phase. The transition to the Upper Fasnia eruption phase coincided with the eruption of more geochemically homogeneous pyroclasts. In total, 62 km3 of tephra were erupted, including 49 km3 of juvenile clasts and > 12 km3 of lithic clasts. The DRE volume of magma erupted was 13 km3 (Lower Fasnia > 5 km3, Upper Fasnia > 8 km3), two thirds of which ( 9-10 km3) was deposited purely by fallout. The Fasnia Member is one of the most complex plinian sequences known.

Validation of automated lobe segmentation on paired inspiratory-expiratory chest CT in 8-14 year-old children with cystic fibrosis.

PubMed

Konietzke, Philip; Weinheimer, Oliver; Wielpütz, Mark O; Savage, Dasha; Ziyeh, Tiglath; Tu, Christin; Newman, Beverly; Galbán, Craig J; Mall, Marcus A; Kauczor, Hans-Ulrich; Robinson, Terry E

2018-01-01

Densitometry on paired inspiratory and expiratory multidetector computed tomography (MDCT) for the quantification of air trapping is an important approach to assess functional changes in airways diseases such as cystic fibrosis (CF). For a regional analysis of functional deficits, an accurate lobe segmentation algorithm applicable to inspiratory and expiratory scans is beneficial. We developed a fully automated lobe segmentation algorithm, and subsequently validated automatically generated lobe masks (ALM) against manually corrected lobe masks (MLM). Paired inspiratory and expiratory CTs from 16 children with CF (mean age 11.1±2.4) acquired at 4 time-points (baseline, 3mon, 12mon, 24mon) with 2 kernels (B30f, B60f) were segmented, resulting in 256 ALM. After manual correction spatial overlap (Dice index) and mean differences in lung volume and air trapping were calculated for ALM vs. MLM. The mean overlap calculated with Dice index between ALM and MLM was 0.98±0.02 on inspiratory, and 0.86±0.07 on expiratory CT. If 6 lobes were segmented (lingula treated as separate lobe), the mean overlap was 0.97±0.02 on inspiratory, and 0.83±0.08 on expiratory CT. The mean differences in lobar volumes calculated in accordance with the approach of Bland and Altman were generally low, ranging on inspiratory CT from 5.7±52.23cm3 for the right upper lobe to 17.41±14.92cm3 for the right lower lobe. Higher differences were noted on expiratory CT. The mean differences for air trapping were even lower, ranging from 0±0.01 for the right upper lobe to 0.03±0.03 for the left lower lobe. Automatic lobe segmentation delivers excellent results for inspiratory and good results for expiratory CT. It may become an important component for lobe-based quantification of functional deficits in cystic fibrosis lung disease, reducing necessity for user-interaction in CT post-processing.

The medial temporal lobe-conduit of parallel connectivity: a model for attention, memory, and perception.

PubMed

Mozaffari, Brian

2014-01-01

Based on the notion that the brain is equipped with a hierarchical organization, which embodies environmental contingencies across many time scales, this paper suggests that the medial temporal lobe (MTL)-located deep in the hierarchy-serves as a bridge connecting supra- to infra-MTL levels. Bridging the upper and lower regions of the hierarchy provides a parallel architecture that optimizes information flow between upper and lower regions to aid attention, encoding, and processing of quick complex visual phenomenon. Bypassing intermediate hierarchy levels, information conveyed through the MTL "bridge" allows upper levels to make educated predictions about the prevailing context and accordingly select lower representations to increase the efficiency of predictive coding throughout the hierarchy. This selection or activation/deactivation is associated with endogenous attention. In the event that these "bridge" predictions are inaccurate, this architecture enables the rapid encoding of novel contingencies. A review of hierarchical models in relation to memory is provided along with a new theory, Medial-temporal-lobe Conduit for Parallel Connectivity (MCPC). In this scheme, consolidation is considered as a secondary process, occurring after a MTL-bridged connection, which eventually allows upper and lower levels to access each other directly. With repeated reactivations, as contingencies become consolidated, less MTL activity is predicted. Finally, MTL bridging may aid processing transient but structured perceptual events, by allowing communication between upper and lower levels without calling on intermediate levels of representation.

The learning curves in living donor hemiliver graft procurement using small upper midline incision.

PubMed

Ikegami, Toru; Harimoto, Norifumi; Shimokawa, Masahiro; Yoshizumi, Tomoharu; Uchiyama, Hideaki; Itoh, Shinji; Okabe, Norihisa; Sakata, Kazuhito; Nagatsu, Akihisa; Soejima, Yuji; Maehara, Yoshihiko

2016-12-01

The learning curve for performing living donor hemiliver procurement (LDHP) via small upper midline incision (UMI) has not been determined. Living donors (n=101) who underwent LDHP via UMI were included to investigate the learning curve using cumulative sum analysis. The cumulative sum analysis showed that nine cases for right lobe (case #23) and 19 cases for left lobe (case #32 in the whole series) are needed for stable and acceptable surgical outcomes in LDHP via UMI. The established phase (n=69, since case #33) had a significantly shorter operative time, a smaller incision size, and less blood loss than the previous learning phase (n=32, serial case number up to the last 19th left lobe case). Multivariate analysis showed that the learning phase, high body mass index ≥25 kg/m 2 , and left lobe graft procurement are the factors associated with surgical events including operative blood loss ≥400 mL, operative time ≥300 minutes, or surgical complications ≥Clavien-Dindo grade II. There is an obvious learning curve in performing LDHP via UMI, and 32 cases including both 19 cases for left lobe and nine cases for right lobe are needed for having stable and acceptable surgical outcomes. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Supplemental Carbon Dioxide Stabilizes the Upper Airway in Volunteers Anesthetized with Propofol.

PubMed

Ruscic, Katarina Jennifer; Bøgh Stokholm, Janne; Patlak, Johann; Deng, Hao; Simons, Jeroen Cedric Peter; Houle, Timothy; Peters, Jürgen; Eikermann, Matthias

2018-05-10

Propofol impairs upper airway dilator muscle tone and increases upper airway collapsibility. Preclinical studies show that carbon dioxide decreases propofol-mediated respiratory depression. We studied whether elevation of end-tidal carbon dioxide (PETCO2) via carbon dioxide insufflation reverses the airway collapsibility (primary hypothesis) and impaired genioglossus muscle electromyogram that accompany propofol anesthesia. We present a prespecified, secondary analysis of previously published experiments in 12 volunteers breathing via a high-flow respiratory circuit used to control upper airway pressure under propofol anesthesia at two levels, with the deep level titrated to suppression of motor response. Ventilation, mask pressure, negative pharyngeal pressure, upper airway closing pressure, genioglossus electromyogram, bispectral index, and change in end-expiratory lung volume were measured as a function of elevation of PETCO2 above baseline and depth of propofol anesthesia. PETCO2 augmentation dose-dependently lowered upper airway closing pressure with a decrease of 3.1 cm H2O (95% CI, 2.2 to 3.9; P < 0.001) under deep anesthesia, indicating improved upper airway stability. In parallel, the phasic genioglossus electromyogram increased by 28% (23 to 34; P < 0.001). We found that genioglossus electromyogram activity was a significant modifier of the effect of PETCO2 elevation on closing pressure (P = 0.005 for interaction term). Upper airway collapsibility induced by propofol anesthesia can be reversed in a dose-dependent manner by insufflation of supplemental carbon dioxide. This effect is at least partly mediated by increased genioglossus muscle activity.

Abscess of residual lobe after pulmonary resection for lung cancer.

PubMed

Ligabue, Tommaso; Voltolini, Luca; Ghiribelli, Claudia; Luzzi, Luca; Rapicetta, Cristian; Gotti, Giuseppe

2008-04-01

Abscess of the residual lobe after lobectomy is a rare but potentially lethal complication. Between January 1975 and December 2006, 1,460 patients underwent elective pulmonary lobectomy for non-small-cell lung cancer at our institution. Abscess of the residual lung parenchyma occurred in 5 (0.3%) cases (4 bilobectomies and 1 lobectomy). Postoperative chest radiography showed incomplete expansion and consolidation of residual lung parenchyma. Flexible bronchoscopy revealed persistent bronchial occlusion from purulent secretions and/or bronchial collapse. Computed tomography in 3 patients demonstrated lung abscess foci. Surgical treatment included completion right pneumonectomy in 3 patients and a middle lobectomy in one. Complications after repeat thoracotomy comprised contralateral pneumonia and sepsis in 1 patient. Residual lobar abscess after lobectomy should be suspected in patients presenting with fever, leukocytosis, bronchial obstruction and lung consolidation despite antibiotic therapy, physiotherapy and bronchoscopy. Computed tomography is mandatory for early diagnosis. Surgical resection of the affected lobe is recommended.

Dynamics and allostery of the ionotropic glutamate receptors and the ligand binding domain.

PubMed

Tobi, Dror

2016-02-01

The dynamics of the ligand-binding domain (LBD) and the intact ionotropic glutamate receptor (iGluR) were studied using Gaussian Network Model (GNM) analysis. The dynamics of LBDs with various allosteric modulators is compared using a novel method of multiple alignment of GNM modes of motion. The analysis reveals that allosteric effectors change the dynamics of amino acids at the upper lobe interface of the LBD dimer as well as at the hinge region between the upper- and lower- lobes. For the intact glutamate receptor the analysis show that the clamshell-like movement of the LBD upper and lower lobes is coupled to the bending of the trans-membrane domain (TMD) helices which may open the channel pore. The results offer a new insight on the mechanism of action of allosteric modulators on the iGluR and support the notion of TMD helices bending as a possible mechanism for channel opening. In addition, the study validates the methodology of multiple GNM modes alignment as a useful tool to study allosteric effect and its relation to proteins dynamics. © 2015 Wiley Periodicals, Inc.

Progressive Atelectasis Secondary to GSW to Airway

DTIC Science & Technology

2009-05-01

compression, cicatrization , adhesion and Progressive Atelectasis Secondary to GSW Military Medicine Radiology Corner, Volume 174 May 2009...in retraction or entire collapse of lung lobes. The next main cause of atelectasis, cicatrization , is also produced by the interaction of...mechanical forces. In cicatrization atelectasis, pulmonary fibrosis stiffens the alveoli, causing a decrease in compliance and alveolar volume

The Tharsis Montes, Mars - Comparison of volcanic and modified landforms

NASA Technical Reports Server (NTRS)

Zimbelman, James R.; Edgett, Kenneth S.

1992-01-01

The three Tharsis Montes shield volcanos, Arsia Mons, Pavonis Mons, and Ascraeus Mons, have broad similarities that have been recognized since the Mariner 9 reconnaissance in 1972. Upon closer examination the volcanos are seen to have significant differences that are due to individual volcanic histories. All three volcanos exhibit the following characteristics: gentle (less than 5 deg) flank slopes, entrants in the northwestern and southeastern flanks that were the source for lavas extending away from each shield, summit caldera(s), and enigmatic lobe-shaped features extending over the plains to the west of each volcano. The three volcanos display different degrees of circumferential graben and trough development in the summit regions, complexity of preserved caldera collapse events, secondary summit-region volcanic construction, and erosion on the lower western flanks due to mass wasting and the processes that formed the large lobe-shaped features. All three lobe-shaped features start at elevations of 10 to 11 km and terminate at 6 km. The complex morphology of the lobe deposits appear to involve some form of catastrophic mass movement followed by effusive and perhaps pyroclastic volcanism.

A rare indication for liver resection.

PubMed

Popescu, I; Zamfir, R; Braşoveanu, V; Boroş, M; Herlea, V

2005-01-01

We present the rare case of a young female with a right upper abdomen tumoral mass and suffering abdominal discomfort. A combination of ultrasonography, computed tomography, magnetic resonance imaging and laparotomy was utilized to conclude a diagnosis of Riedel's lobe. Laparotomy and a resection of Riedel's lobe were selected as the correct therapeutic solutions.

Assessment of upper airway mechanics during sleep.

PubMed

Farré, Ramon; Montserrat, Josep M; Navajas, Daniel

2008-11-30

Obstructive sleep apnea, which is the most prevalent sleep breathing disorder, is characterized by recurrent episodes of upper airway collapse and reopening. However, the mechanical properties of the upper airway are not directly measured in routine polysomnography because only qualitative sensors (thermistors for flow and thoraco-abdominal bands for pressure) are used. This review focuses on two techniques that quantify upper airway obstruction during sleep. A Starling model of collapsible conduit allows us to interpret the mechanics of the upper airway by means of two parameters: the critical pressure (Pcrit) and the upstream resistance (Rup). A simple technique to measure Pcrit and Rup involves the application of different levels of continuous positive airway pressure (CPAP) during sleep. The forced oscillation technique is another non-invasive procedure for quantifying upper airway impedance during the breathing cycle in sleep studies. The latest developments in these two methods allow them to be easily applied on a routine basis in order to more fully characterize upper airway mechanics in patients with sleep breathing disorders.

Biologic lung volume reduction in advanced upper lobe emphysema: phase 2 results.

PubMed

Criner, Gerard J; Pinto-Plata, Victor; Strange, Charlie; Dransfield, Mark; Gotfried, Mark; Leeds, William; McLennan, Geoffrey; Refaely, Yael; Tewari, Sanjiv; Krasna, Mark; Celli, Bartolome

2009-05-01

Biologic lung volume reduction (BioLVR) is a new endobronchial treatment for advanced emphysema that reduces lung volume through tissue remodeling. Assess the safety and therapeutic dose of BioLVR hydrogel in upper lobe predominant emphysema. Open-labeled, multicenter phase 2 dose-ranging studies were performed with BioLVR hydrogel administered to eight subsegmental sites (four in each upper lobe) involving: (1) low-dose treatment (n = 28) with 10 ml per site (LD); and (2) high-dose treatment (n = 22) with 20 ml per site (HD). Safety was assessed by the incidence of serious medical complications. Efficacy was assessed by change from baseline in pulmonary function tests, dyspnea score, 6-minute walk distance, and health-related quality of life. After treatment there were no deaths and four serious treatment-related complications. A reduction in residual volume to TLC ratio at 12 weeks (primary efficacy outcome) was achieved with both LD (-6.4 +/- 9.3%; P = 0.002) and HD (-5.5 +/- 9.4%; P = 0.028) treatments. Improvements in pulmonary function in HD (6 mo: DeltaFEV(1) = +15.6%; P = 0.002; DeltaFVC = +9.1%; P = 0.034) were greater than in LD patients (6 mo: DeltaFEV(1) = +6.7%; P = 0.021; DeltaFVC = +5.1%; P = 0.139). LD- and HD-treated groups both demonstrated improved symptom scores and health-related quality of life. BioLVR improves physiology and functional outcomes up to 6 months with an acceptable safety profile in upper lobe predominant emphysema. Overall improvement was greater and responses more durable with 20 ml per site than 10 ml per site dosing. Clinical trial registered with www.clinicaltrials.gov (NCT 00435253 and NCT 00515164).

Pyroclastic flow deposits on Venus as indicators of renewed magmatic activity

NASA Astrophysics Data System (ADS)

Campbell, Bruce A.; Morgan, Gareth A.; Whitten, Jennifer L.; Carter, Lynn M.; Glaze, Lori S.; Campbell, Donald B.

2017-07-01

Radar bright deposits on Venus that have diffuse margins suggest eruptions that distribute debris over large areas due to ground-hugging flows from plume collapse. We examine deposits in eastern Eistla, western Eistla, Phoebe, and Dione Regiones using Magellan data and Earth-based radar maps. The radar bright units have no marginal lobes or other features consistent with viscous flow. Their morphology, radar echo strength, polarization properties, and microwave emissivity are consistent with mantling deposits composed of few centimeters or larger clasts. This debris traveled downhill up to 100 km on modest slopes and blanketed lava flows and tectonic features to depths of tens of centimeters to a few meters over areas up to 40 × 103 km2. There is evidence for ongoing removal and exhumation of previously buried terrain. A newly identified occurrence is associated with a ridge belt south of Ushas Mons. We also note radar bright streaks of coarse material west of Rona Chasma that reflect the last traces of a deposit mobilized by winds from the formation of Mirabeau crater. If the radar bright units originate by the collapse of eruption columns, with coarse fragmental material entrained and fluidized by hot gases, then their extent suggests large erupted volatile (CO2 or H2O) amounts. We propose that these deposits reflect the early stage of renewed magmatic activity, with volatile-rich, disrupted magma escaping through vents in fractured regions of the upper crust. Rapidly eroding under Venus surface conditions or buried by subsequent eruptions, these markers of recently renewed activity have disappeared from older regions.

The morphology, processes, and evolution of Monterey Fan: a revisit

USGS Publications Warehouse

Gardner, James V.; Bohannon, Robert G.; Field, Michael E.; Masson, Douglas G.

2010-01-01

Long-range (GLORIA) and mid-range (TOBI) sidescan imagery and seismic-reflection profiles have revealed the surface morphology and architecture of the complete Monterey Fan. The fan has not developed a classic wedge shape because it has been blocked for much of its history by Morro Fracture Zone. The barrier has caused the fan to develop an upper-fan and lower-fan sequence that are distinctly different from one another. The upper-fan sequence is characterized by Monterey and Ascension Channels and associated Monterey Channel-levee system. The lower-fan sequence is characterized by depositional lobes of the Ascension, Monterey, and Sur-Parkington-Lucia systems, with the Monterey depositional lobe being the youngest. Presently, the Monterey depositional lobe is being downcut because the system has reached a new, lower base level in the Murray Fracture Zone. A five-step evolution of Monterey Fan is presented, starting with initial fan deposition in the Late Miocene, about 5.5 Ma. This first stage was one of filling bathymetric lows in the oceanic basement in what was to become the upper-fan segment. The second stage involved filling the bathymetric low on the north side of Morro Fracture Zone, and probably not much sediment was transported beyond the fracture zone. The third stage witnessed sediment being transported around both ends of Morro Fracture Zone and initial sedimentation on the lower-fan segment. During the fourth stage Ascension Channel was diverted into Monterey Channel, thereby cutting off sedimentation to the Ascension depositional lobe.

How Hives Collapse: Allee Effects, Ecological Resilience, and the Honey Bee

PubMed Central

Dennis, Brian; Kemp, William P.

2016-01-01

We construct a mathematical model to quantify the loss of resilience in collapsing honey bee colonies due to the presence of a strong Allee effect. In the model, recruitment and mortality of adult bees have substantial social components, with recruitment enhanced and mortality reduced by additional adult bee numbers. The result is an Allee effect, a net per-individual rate of hive increase that increases as a function of adult bee numbers. The Allee effect creates a critical minimum size in adult bee numbers, below which mortality is greater than recruitment, with ensuing loss of viability of the hive. Under ordinary and favorable environmental circumstances, the critical size is low, and hives remain large, sending off viably-sized swarms (naturally or through beekeeping management) when hive numbers approach an upper stable equilibrium size (carrying capacity). However, both the lower critical size and the upper stable size depend on many parameters related to demographic rates and their enhancement by bee sociality. Any environmental factors that increase mortality, decrease recruitment, or interfere with the social moderation of these rates has the effect of exacerbating the Allee effect by increasing the lower critical size and substantially decreasing the upper stable size. As well, the basin of attraction to the upper stable size, defined by the model potential function, becomes narrower and shallower, indicating the loss of resilience as the hive becomes subjected to increased risk of falling below the critical size. Environmental effects of greater severity can cause the two equilibria to merge and the basin of attraction to the upper stable size to disappear, resulting in collapse of the hive from any initial size. The model suggests that multiple proximate causes, among them pesticides, mites, pathogens, and climate change, working singly or in combinations, could trigger hive collapse. PMID:26910061

[INCIDENCE AND SURGICAL IMPORTANCE OF PYRAMIDAL LOBE AND TUBERCLE OF THE THYROID GLAND: A PROSPECTIVE STUDY].

PubMed

Kovacić, Marijan; Kovadcić, Ivan

2015-01-01

The pyramidal lobe and tubercles are common anatomic variations of the thyroid gland, and their frequency is highly represented. While pyramidal lobe requires additional seriousness in identifying and its removal, especially in patients with hyperthyroidism and thyroid cancer, the presence of tubercles is desirable. Tubercle is covered by recurrent laryngeal nerve and directs the surgeon in his search and besides this, serves to facilitate detection of the upper parathyroid glands. In this prospective study we analysed 342 patients who underwent total thyroidectomy in the period from January 2009 to March 2015. We looked at the incidence and anatomic characteristics of pyramidal lobe and tubercles of the thyroid gland. The pyramidal lobe was present in 52.3% of the patients with more frequent central and left placement. Bilateral tubercles were present in 14.9%, while position right-sided phenomenon was represented in 39.5% and 18.5% in lower left (64.3% patients). Their prevalence by gender showed no significant difference (p = 0.59; p = 0.2). Associated presence of pyramidal lobe and tubercles on one or both sides is highly represented in our group of patients (34%), also with no differences by gender (p = 0.29). Length of the pyramidal lobe ranged from 1.3 to 4.7 cm (average 2.3 cm), and the size of tubercles in 36% of patients was over 1 cm. Recurrent laryngeal nerve was only in 1.8% placed laterally of tubercles, and the upper parathyroid gland in 95.4% was located above tubercle. Considering that only 16.5% of our patients did not have any of these anatomical variations, their presence during surgery is the rule, not the exception.

Dosimetric evaluation of the feasibility of stereotactic body radiotherapy for primary lung cancer with lobe-specific selective elective nodal irradiation

PubMed Central

Komatsu, Tetsuya; Kunieda, Etsuo; Kitahara, Tadashi; Akiba, Takeshi; Nagao, Ryuta; Fukuzawa, Tsuyoshi

2016-01-01

More than 10% of all patients treated with stereotactic body radiotherapy (SBRT) for primary lung cancer develop regional lymph node recurrence. We evaluated the dosimetric feasibility of SBRT with lobe-specific selective elective nodal irradiation (ENI) on dose–volume histograms. A total of 21 patients were treated with SBRT for Stage I primary lung cancer between January 2010 and June 2012 at our institution. The extents of lobe-specific selective ENI fields were determined with reference to prior surgical reports. The ENI fields included lymph node stations (LNS) 3 + 4 + 11 for the right upper lobe tumors, LNS 7 + 11 for the right middle or lower lobe tumors, LNS 5 + 11 for the left upper lobe tumors, and LNS 7 + 11 for the left lower lobe tumors. A composite plan was generated by combining the ENI plan and the SBRT plan and recalculating for biologically equivalent doses of 2 Gy per fraction, using a linear quadratic model. The V20 of the lung, D1cm3 of the spinal cord, D1cm3 and D10cm3 of the esophagus and D10cm3 of the tracheobronchial wall were evaluated. Of the 21 patients, nine patients (43%) could not fulfill the dose constraints. In all these patients, the distance between the planning target volume (PTV) of ENI (PTVeni) and the PTV of SBRT (PTVsrt) was ≤2.0 cm. Of the three patients who developed regional metastasis, two patients had isolated lymph node failure, and the lymph node metastasis was included within the ENI field. When the distance between the PTVeni and PTVsrt is >2.0 cm, SBRT with selective ENI may therefore dosimetrically feasible. PMID:26566656

Predictors of pneumothorax following endoscopic valve therapy in patients with severe emphysema.

PubMed

Gompelmann, Daniela; Lim, Hyun-Ju; Eberhardt, Ralf; Gerovasili, Vasiliki; Herth, Felix Jf; Heussel, Claus Peter; Eichinger, Monika

2016-01-01

Endoscopic valve implantation is an effective treatment for patients with advanced emphysema. Despite the minimally invasive procedure, valve placement is associated with risks, the most common of which is pneumothorax. This study was designed to identify predictors of pneumothorax following endoscopic valve implantation. Preinterventional clinical measures (vital capacity, forced expiratory volume in 1 second, residual volume, total lung capacity, 6-minute walk test), qualitative computed tomography (CT) parameters (fissure integrity, blebs/bulla, subpleural nodules, pleural adhesions, partial atelectasis, fibrotic bands, emphysema type) and quantitative CT parameters (volume and low attenuation volume of the target lobe and the ipsilateral untreated lobe, target air trapping, ipsilateral lobe volume/hemithorax volume, collapsibility of the target lobe and the ipsilateral untreated lobe) were retrospectively evaluated in patients who underwent endoscopic valve placement (n=129). Regression analysis was performed to compare those who developed pneumothorax following valve therapy (n=46) with those who developed target lobe volume reduction without pneumothorax (n=83). Low attenuation volume% of ipsilateral untreated lobe (odds ratio [OR] =1.08, P=0.001), ipsilateral untreated lobe volume/hemithorax volume (OR =0.93, P=0.017), emphysema type (OR =0.26, P=0.018), pleural adhesions (OR =0.33, P=0.012) and residual volume (OR =1.58, P=0.012) were found to be significant predictors of pneumothorax. Fissure integrity (OR =1.16, P=0.075) and 6-minute walk test (OR =1.05, P=0.077) were also indicative of pneumothorax. The model including the aforementioned parameters predicted whether a patient would experience a pneumothorax 84% of the time (area under the curve =0.84). Clinical and CT parameters provide a promising tool to effectively identify patients at high risk of pneumothorax following endoscopic valve therapy.

Predictors of pneumothorax following endoscopic valve therapy in patients with severe emphysema

PubMed Central

Gompelmann, Daniela; Lim, Hyun-ju; Eberhardt, Ralf; Gerovasili, Vasiliki; Herth, Felix JF; Heussel, Claus Peter; Eichinger, Monika

2016-01-01

Background Endoscopic valve implantation is an effective treatment for patients with advanced emphysema. Despite the minimally invasive procedure, valve placement is associated with risks, the most common of which is pneumothorax. This study was designed to identify predictors of pneumothorax following endoscopic valve implantation. Methods Preinterventional clinical measures (vital capacity, forced expiratory volume in 1 second, residual volume, total lung capacity, 6-minute walk test), qualitative computed tomography (CT) parameters (fissure integrity, blebs/bulla, subpleural nodules, pleural adhesions, partial atelectasis, fibrotic bands, emphysema type) and quantitative CT parameters (volume and low attenuation volume of the target lobe and the ipsilateral untreated lobe, target air trapping, ipsilateral lobe volume/hemithorax volume, collapsibility of the target lobe and the ipsilateral untreated lobe) were retrospectively evaluated in patients who underwent endoscopic valve placement (n=129). Regression analysis was performed to compare those who developed pneumothorax following valve therapy (n=46) with those who developed target lobe volume reduction without pneumothorax (n=83). Finding Low attenuation volume% of ipsilateral untreated lobe (odds ratio [OR] =1.08, P=0.001), ipsilateral untreated lobe volume/hemithorax volume (OR =0.93, P=0.017), emphysema type (OR =0.26, P=0.018), pleural adhesions (OR =0.33, P=0.012) and residual volume (OR =1.58, P=0.012) were found to be significant predictors of pneumothorax. Fissure integrity (OR =1.16, P=0.075) and 6-minute walk test (OR =1.05, P=0.077) were also indicative of pneumothorax. The model including the aforementioned parameters predicted whether a patient would experience a pneumothorax 84% of the time (area under the curve =0.84). Interpretation Clinical and CT parameters provide a promising tool to effectively identify patients at high risk of pneumothorax following endoscopic valve therapy. PMID:27536088

High-resolution mapping of the 1998 lava flows at Axial Seamount

NASA Astrophysics Data System (ADS)

Chadwick, B.; Clague, D. A.; Embley, R. W.; Caress, D. W.; Paduan, J. B.; Sasnett, P.

2011-12-01

Axial Seamount (an active hotspot volcano on the Juan de Fuca Ridge) last erupted in 1998 and produced two lava flows (a "northern" and a "southern" flow) along the upper south rift zone separated by a distance of 4 km. Geologic mapping of the 1998 lava flows has been carried out with a combination of visual observations from multiple submersible dives since 1998, and with high-resolution bathymetry, most recently collected with the MBARI mapping AUV (the D. Allan B.) since 2007. The new mapping results revise and update the previous preliminary flow outlines, areas, and volumes. The high-resolution bathymetry (1-m grid cell size) allows eruptive fissures fine-scale morphologic features to be resolved with new and remarkable clarity. The morphology of both lava flows can be interpreted as a consequence of a specific sequence of events during their emplacement. The northern sheet flow is long (4.6 km) and narrow (500 m), and erupted in the SE part of Axial caldera, where it temporarily ponded and inflated on relatively flat terrain before draining out southward toward steeper slopes. The inflation and drain-out of this sheet flow by ~ 3.5 m over 2.5 hours was previously documented by a monitoring instrument that was caught in the lava flow. Our geologic mapping shows that the morphology of the northern sheet flow varies along its length primarily due to gradients in the underlying slope and processes active during flow emplacement. The original morphology of the sheet flow where it ponded is lobate, with pillows near the margins, whereas the central axis of drain-out and collapse is floored with lineated, ropy, and jumbled lava morphologies. The southern lava flow, in contrast, is mostly pillow lava where it cascaded down the steep slope on the east flank of the south rift zone, but also has a major area of collapse where lava ponded temporarily near the rift axis. These results show that submarine lava flows have more subsurface hydraulic connectivity than has previously been supposed. For example, a common morphologic feature at the downslope ends of the 1998 lava flows (and on many older flows at Axial) is large lobes covered with pillows that are 200-500-m in diameter, 10-20-m thick, and are capped with centered, dendritic collapse areas 5-10 m deep. These large lobes show clear evidence of inflation and drain-out, and are often arranged in a shingle-like fashion, implying progressive emplacement at decreasing distance from the eruptive vent with time. Such features are impossible to discern from visual observations alone and are only revealed by high-resolution bathymetry.

Southern Laurentide ice lobes were created by ice streams: Des Moines Lobe in Minnesota, USA

USGS Publications Warehouse

Patterson, C.J.

1997-01-01

Regional mapping in southern Minnesota has illuminated a suite of landforms developed by the Des Moines Lobe that delimit the position of the lobe at its maximum and at lesser readvances. The ice lobe repeatedly advanced, discharged its subglacial water, and subsequently stagnated. Recent glaciological research on Antarctic ice streams has led some glacial geologists to postulate that ice streams drained parts of the marine-based areas of the Laurentide Ice Sheet. I postulate that such ice streams may develop in land-based areas of an ice sheet as well, and that the Des Moines Lobe, 200 km wide and 900 km long, was an outlet glacier of an ice stream. It appears to have been able to advance beyond the Laurentide Ice Sheet as long as adequate water pressure was maintained. However, the outer part of the lobe stagnated because subglacial water that facilitated the flow was able to drain away through tunnel valleys. Stagnation of the lobe is not equivalent to stoppage of the ice stream, because ice repeatedly advanced into and onto the stagnant margins, stacking ice and debris. Similar landforms are also seen in other lobes of the upper midwestern United States.

Dynamics of sonoluminescing bubbles within a liquid hammer device.

PubMed

Urteaga, Raúl; García-Martínez, Pablo Luis; Bonetto, Fabián J

2009-01-01

We studied the dynamics of a single sonoluminescing bubble (SBSL) in a liquid hammer device. In particular, we investigated the phosphoric acid-xenon system, in which pulses up to four orders of magnitude brighter than SBSL in water systems (about 10;{12} photons per pulse) have been previously reported [Chakravarty, Phys. Rev. E 69, 066317 (2004)]. We used stroboscopic photography and a Mie scattering technique in order to measure the radius evolution of the bubbles. Under adequate conditions we may position a bubble at the bottom of the tube (cavity) and a second bubble trapped at the middle of the tube (upper bubble). During its collapse, the cavity produces the compression of the liquid column. This compression drives impulsively the dynamics of the upper bubble. Our measurements reveal that the observed light emissions produced by the upper bubble are generated at its second collapse. We employed a simple numerical model to investigate the conditions that occur during the upper bubble collapse. We found good agreement between numerical and experimental values for the light intensity (fluence) and light pulse widths. Results from the model show that the light emission is increased mainly due to an increase in noble gas ambient radius and not because the maximum temperature increases. Even for the brightest pulses obtained ( 2x10;{13} photons, about 20W of peak power) the maximum temperatures computed for the upper bubble are always lower than 20000K .

Computed tomography of partial anomalous pulmonary venous connection in adults.

PubMed

Haramati, Linda B; Moche, Ilana E; Rivera, Vivian T; Patel, Pavni V; Heyneman, Laura; McAdams, H Page; Issenberg, Henry J; White, Charles S

2003-01-01

To systematically describe the imaging features and clinical correlates of a partial anomalous pulmonary venous connection diagnosed on computed tomography (CT) in adults. Twenty-nine adults with a partial anomalous pulmonary venous connection on CT were retrospectively identified. There were 19 women and 10 men, with a mean age of 53 (range: 19-83) years. Four cases were identified by review of 1825 consecutive chest CT reports from July 2000-July 2001, and 25 cases were culled from chest radiology teaching files at 3 institutions. Inclusion criteria were availability of CT images and medical charts. Chest radiographs (25 of 29 cases) were reviewed for mediastinal contour abnormalities, heart size, and pulmonary vascular pattern. Chest CT scans were reviewed for location, size, and drainage site of the anomalous vein; presence or absence of a pulmonary vein in the normal location; cardiac size and configuration; and pulmonary vasculature. Charts were reviewed for evidence of pulmonary and cardiovascular disease, history of congenital heart disease, and results of other cardiac imaging. The prevalence of a partial anomalous pulmonary venous connection was 0.2% (4 of 1825 chest CT reports). Seventy-nine percent (23 of 29 patients) had an anomalous left upper lobe vein connecting to a persistent left vertical vein, only 5% (1 of 23 patients) of whom had a left upper lobe vein in the normal location. Seventeen percent (5 of 29 patients) had an anomalous right upper lobe vein draining into the superior vena cava, 60% (3 of 5 patients) of whom also had a right upper lobe pulmonary vein in the normal location. One patient (3%) had an anomalous right lower lobe vein draining into the suprahepatic inferior vena cava. Chest radiographic findings were abnormal left mediastinal contour in 64% (15 of 25 patients), abnormal right mediastinal contour in 8% (2 of 25 patients), and cardiomegaly in 24% (6 of 25 patients). Computed tomography findings were cardiomegaly in 48% (14 of 29 patients), right atrial enlargement in 31% (9 of 29 patients), right ventricular enlargement in 31% (9 of 29 patients), and pulmonary artery enlargement in 14% (4 of 29 patients). Pulmonary or cardiovascular symptoms were present in 69% (20 of 29 patients), 55% (11 of 20 patients) of whom had specific alternative diagnoses (excluding congestive heart failure and pulmonary hypertension) to explain the symptoms. Only 1 patient (3%) was diagnosed with a secundum atrial septal defect. A partial anomalous pulmonary venous connection was seen in 0.2% of adults on CT. In contrast to previous series focusing on children, the anomalous vein in adults was most commonly from the left upper lobe, in women, and infrequently associated with atrial septal defects.

Arytenoid lateralization for management of combined laryngeal paralysis and laryngeal collapse in small dogs.

PubMed

Nelissen, Pieter; White, Richard A S

2012-02-01

To identify combined laryngeal paralysis and collapse in small dogs and describe postoperative outcome after arytenoid lateralization. Case series. Small nonbrachycephalic breed dogs with laryngeal paralysis and collapse (n = 6). Medical records of small breed dogs with airway problems and undergoing laryngeal surgery (January-December 2008) were reviewed. Dogs with combined laryngeal paralysis and laryngeal collapse (LPLC) had arytenoid lateralization. The immediate, 4 week and 6 month postoperative outcomes were described. Direct visual laryngeal exam under a light plane of anesthesia revealed bilateral failure of arytenoid and vocal fold movement and concurrent bilateral medial folding with contact of the cuneiform processes in all dogs. None of the dogs had intra- or immediate postoperative complications after arytenoid lateralization. Two dogs required a 2nd contralateral procedure. Follow-up after 6 months revealed marked improvement in clinical signs related to upper airway obstruction, but all dogs continued to have mild respiratory noise. Concurrent laryngeal paralysis and collapse should be considered as part of the differential diagnosis for small, nonbrachycephalic dogs with upper airway disease. Arytenoid lateralization resulted in improvement of clinical signs related to obstructive airway disease. © Copyright 2011 by The American College of Veterinary Surgeons.

Histological findings and immunohistochemical surfactant protein A (SP-A) expression in asphyxia: its application in the diagnosis of drowning.

PubMed

Pérez-Cárceles, M D; Sibón, A; Vizcaya, M A; Osuna, E; Gómez-Zapata, M; Luna, A; Martínez-Díaz, F

2008-09-01

The histopathological alterations that permit the diagnosis of death by asphyxia are very unspecific, although pulmonary alterations are of great importance in this respect. The postmortem diagnosis of drowning, particularly, continues to be one of the most difficult in forensic pathology. The aim of this study is to jointly evaluate microscopic findings and immunohistochemical surfactant protein A (SP-A) expression in the upper and lower lobes of lungs in different causes of death, and their possible application to the diagnosis of drowning. We studied 120 cadavers from subjects with a mean age of 48.73 years (SD 19.45; range 2-86 years), and with a mean post-mortem interval of 30 hours (SD 39.59; range 3-216 hours). According to the scene, cause and circumstances of death, and autopsy findings, cases were classified into groups as follows: (a) drowning (n=47); (b) other asphyxia (n=44) and (c) other causes (n=29). In the upper and lower lobes of lungs, histological studies of H&E staining and immunohistochemical surfactant protein A expression were made. The presence and severity of congestion, haemorrhage and oedema, together with immunohistochemical SP-A expression, may have a diagnostic value in differentiating asphyxia and drowning from other causes of death, and drowning from other types of asphyxia. Our findings suggest that both lobes should be investigated to establish the diagnosis, although the findings in the upper lobe might be the most important for differentiating the exact cause of death.

The Small Breathing Amplitude at the Upper Lobes Favors the Attraction of Polymorphonuclear Neutrophils to Mycobacterium tuberculosis Lesions and Helps to Understand the Evolution toward Active Disease in An Individual-Based Model

PubMed Central

Cardona, Pere-Joan; Prats, Clara

2016-01-01

Infection with Mycobacterium tuberculosis (Mtb) can induce two kinds of lesions, namely proliferative and exudative. The former are based on the presence of macrophages with controlled induction of intragranulomatous necrosis, and are even able to stop its physical progression, thus avoiding the induction of active tuberculosis (TB). In contrast, the most significant characteristic of exudative lesions is their massive infiltration with polymorphonuclear neutrophils (PMNs), which favor enlargement of the lesions and extracellular growth of the bacilli. We have built an individual-based model (IBM) (known as “TBPATCH”) using the NetLogo interface to better understand the progression from Mtb infection to TB. We have tested four main factors previously identified as being able to favor the infiltration of Mtb-infected lesions with PMNs, namely the tolerability of infected macrophages to the bacillary load; the capacity to modulate the Th17 response; the breathing amplitude (BAM) (large or small in the lower and upper lobes respectively), which influences bacillary drainage at the alveoli; and the encapsulation of Mtb-infected lesions by the interlobular septae that structure the pulmonary parenchyma into secondary lobes. Overall, although all the factors analyzed play some role, the small BAM is the major factor determining whether Mtb-infected lesions become exudative, and thus induce TB, thereby helping to understand why this usually takes place in the upper lobes. This information will be very useful for the design of future prophylactic and therapeutic approaches against TB. PMID:27065951

The Small Breathing Amplitude at the Upper Lobes Favors the Attraction of Polymorphonuclear Neutrophils to Mycobacterium tuberculosis Lesions and Helps to Understand the Evolution toward Active Disease in An Individual-Based Model.

PubMed

Cardona, Pere-Joan; Prats, Clara

2016-01-01

Infection with Mycobacterium tuberculosis (Mtb) can induce two kinds of lesions, namely proliferative and exudative. The former are based on the presence of macrophages with controlled induction of intragranulomatous necrosis, and are even able to stop its physical progression, thus avoiding the induction of active tuberculosis (TB). In contrast, the most significant characteristic of exudative lesions is their massive infiltration with polymorphonuclear neutrophils (PMNs), which favor enlargement of the lesions and extracellular growth of the bacilli. We have built an individual-based model (IBM) (known as "TBPATCH") using the NetLogo interface to better understand the progression from Mtb infection to TB. We have tested four main factors previously identified as being able to favor the infiltration of Mtb-infected lesions with PMNs, namely the tolerability of infected macrophages to the bacillary load; the capacity to modulate the Th17 response; the breathing amplitude (BAM) (large or small in the lower and upper lobes respectively), which influences bacillary drainage at the alveoli; and the encapsulation of Mtb-infected lesions by the interlobular septae that structure the pulmonary parenchyma into secondary lobes. Overall, although all the factors analyzed play some role, the small BAM is the major factor determining whether Mtb-infected lesions become exudative, and thus induce TB, thereby helping to understand why this usually takes place in the upper lobes. This information will be very useful for the design of future prophylactic and therapeutic approaches against TB.

CE verbal episodic memory impairment in schizophrenia: a comparison with frontal lobe lesion patients.

PubMed

Christensen, Bruce K; Patrick, Regan E; Stuss, Donald T; Gillingham, Susan; Zipursky, Robert B

2013-01-01

Schizophrenia (SCZ)-related verbal memory impairment is hypothesized to be mediated, in part, by frontal lobe (FTL) dysfunction. However, little research has contrasted the performance of SCZ patients with that of patients exhibiting circumscribed frontal lesions. The current study compared verbal episodic memory in patients with SCZ and focal FTL lesions (left frontal, LF; right frontal, RF; and bi-frontal, BF) on a four-trial list learning task consisting of three lists of varying semantic organizational structure. Each dependent variable was examined at two levels: scores collapsed across all four trials and learning scores (i.e., trial 4-trial 1). Performance deficits were observed in each patient group across most dependent measures at both levels. Regarding patient group differences, SCZ patients outperformed LF/BF patients (i.e., either learning scores or scores collapsed across trial) on free recall, primacy, primary memory, secondary memory, and subjective organization, whereas they only outperformed RF patients on the semantically blocked list on recency and primary memory. Collectively, these results indicate that the pattern of memory performance is largely similar between patients with SCZ and those with RF lesions. These data support tentative arguments that verbal episodic memory deficits in SCZ may be mediated by frontal dysfunction in the right hemisphere.

Structure of the reconnection layer and the associated slow shocks: Two-dimensional simulations of a Riemann problem

NASA Astrophysics Data System (ADS)

Cremer, Michael; Scholer, Manfred

2000-12-01

The kinetic structure of the reconnection layer in the magnetotail is investigated by two-dimensional hybrid simulations. As a proxy, the solution of the Riemann problem of the collapse of a current sheet with a normal magnetic field component is considered for two cases of the plasma beta (particle to magnetic field pressure): β=0.02 and β=0.002. The collapse results in an expanding layer of compressed and heated plasma, which is accelerated up to the Alfvén speed vA. The boundary layer separating this hot reconnection like layer from the cold lobe plasma is characterized by a beam of back-streaming ions with a field-aligned bulk speed of ~=2vA relative to the cold lobe ion population at rest. As a consequence, obliquely propagating waves are excited via the electromagnetic ion/ion cyclotron instability, which led to perpendicular heating of the ions in the boundary layer as well as further outside the layer in the lobe. In both regions, waves are found which propagate almost parallel to the magnetic field and which are identified as Alfvén ion cyclotron (AIC) waves. These waves are excited by the temperature anisotropy instability. The temperature anisotropy increases with decreasing plasma beta. Thus the anisotropy threshold of the instability is exceeded even in the case of a rather small beta value. The AIC waves, when convected downstream of what can be defined as the the slow shock, make an important contribution to the ion thermalization process. More detailed information on the dissipation process in the slow shocks is gained by analyzing individual ion trajectories.

Fermi-LAT and Suzaku observations of the radio galaxy Centaurus B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katsuta, J.; Tanaka, Y. T.; Stawarz, Ł.

2013-01-28

Centaurus B is a nearby radio galaxy positioned in the southern hemisphere close to the Galactic plane. Here, in this work, we present a detailed analysis of about 43 months of accumulated Fermi-LAT data of the γ-ray counterpart of the source initially reported in the 2nd Fermi-LAT catalog, and of newly acquired Suzaku X-ray data. We confirm its detection at GeV photon energies and analyze the extension and variability of the γ-ray source in the LAT dataset, in which it appears as a steady γ-ray emitter. The X-ray core of Centaurus B is detected as a bright source of amore » continuum radiation. We do not detect, however, any diffuse X-ray emission from the known radio lobes, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. Two scenarios that connect the X-ray and γ-ray properties are considered. In the first one, we assume that the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. In this case, modeling the inverse-Compton emission shows that the observed γ-ray flux of the source may in principle be produced within the lobes. This association would imply that efficient in-situ acceleration of the radiating electrons is occurring and that the lobes are dominated by the pressure from the relativistic particles. In the second scenario, with the diffuse X-ray emission well below the Suzaku upper limits, the lobes in the system are instead dominated by the magnetic pressure. In this case, the observed γ-ray flux is not likely to be produced within the lobes, but instead within the nuclear parts of the jet. In conclusion, by means of synchrotron self-Compton modeling, we show that this possibility could be consistent with the broad-band data collected for the unresolved core of Centaurus B, including the newly derived Suzaku spectrum.« less

First record of lobed trace fossils in Brazil's Upper Cretaceous paleosols: Rhizoliths or evidence of insects and their social behavior?

NASA Astrophysics Data System (ADS)

Luciano do Nascimento, Diego; Batezelli, Alessandro; Bernardes Ladeira, Francisco Sérgio

2017-11-01

This is the first report of trace fossils potentially associated with insect social behavior in sandy and well-drained paleosols of the Upper Cretaceous continental sequence of Brazil. The trace fossils consist of dozens of lobed and vertical structures cemented by CaCO3 and preserved mainly in full relief in paleosols of the Marilia Formation (Bauru Basin) in the state of Minas Gerais. The described ichnofossils are predominantly vertical, up to 2 m long, and are composed of horizontal lobed structures connected by vertical tunnel-like structures that intersect in the center and at the edges. The lobed structures range from 3 to 15 cm long and 2-6 cm thick. Two different hypotheses are analyzed to explain the origin of the trace fossils; the less probable one is that the structures are laminar calcretes associated with rhizoliths and rhizoconcretions. The hypothesis involving social insects was considered because the trace fossils described herein partially resemble a modern ant nest and the ichnofossil Daimoniobarax. The micromorphological analysis of the lobed and tunnel-like structures indicates modifications of the walls, such as the presence of inorganic fluidized linings, dark linings and oriented grains, supporting the hypothesis that they are chambers and shafts. The architecture and size of the reported nests suggest the possibility that social insect colonies existed during the Maastrichtian and are direct evidence of the social behavior and reproductive strategies of the Cretaceous pedofauna.

Outcomes of various transplant procedures (single, sparing, inverted) in living-donor lobar lung transplantation.

PubMed

Date, Hiroshi; Aoyama, Akihiro; Hijiya, Kyoko; Motoyama, Hideki; Handa, Tomohiro; Kinoshita, Hideyuki; Baba, Shiro; Mizota, Toshiyuki; Minakata, Kenji; Chen-Yoshikawa, Toyofumi F

2017-02-01

In standard living-donor lobar lung transplantation (LDLLT), the right and left lower lobes from 2 healthy donors are implanted. Because of the difficulty encountered in finding 2 donors with ideal size matching, various transplant procedures have been developed in our institution. The purpose of this retrospective study was to compare outcomes of nonstandard LDLLT with standard LDLLT. Between June 2008 and January 2016, we performed 65 LDLLTs for critically ill patients. Functional size matching was performed by estimating graft forced vital capacity based on the donor's measured forced vital capacity and the number of pulmonary segments implanted. For anatomical size matching, 3-dimensional computed tomography volumetry was performed. In cases of oversize mismatch, single-lobe transplant or downsizing transplant was performed. In cases of undersize mismatch, native upper lobe sparing transplant or right-left inverted transplant was performed. In right-left inverted transplants, the donor's right lower lobe was inverted and implanted into the recipient's left chest cavity. Twenty-nine patients (44.6%) received nonstandard LDLLT, including 12 single-lobe transplants, 7 native upper lobe sparing transplants, 6 right-left inverted transplants, 2 sparing + inverted transplants, and 2 others. Thirty-six patients (57.4%) received standard LDLLT. Three- and five-year survival rates were similar between the 2 groups (89.1% and 76.6% after nonstandard LDLLT vs 78.0% and 71.1% after standard LDLLT, P = .712). Various transplant procedures such as single, sparing and inverted transplants are valuable options when 2 donors with ideal size matching are not available for LDLLT. Copyright © 2016 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

Injection of coal combustion byproducts into the Omega Mine for the reduction of acid mine drainage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, T.A.; Moran, T.C.; Broschart, D.W.

1998-12-31

The Omega Mine Complex is located outside of Morgantown, West Virginia. The mine is in the Upper Freeport Coal, an acid-producing coal seam. The coal was mined in a manner that has resulted in acid mine drainage (AMD) discharges at multiple points. During the 1990`s, the West Virginia Division of Environmental Protection (WVDEP) assumed responsibility for operating a collection and treatment system for the AMD. Collection and treatment costs are approximately $300,000 per year. An innovative procedure of injecting grout into the mine workings to reduce AMD and the resulting treatment costs is proposed. The procedure involves injecting grout mixesmore » composed primarily of coal combustion byproducts (CCB`s) and water, with a small quantity of cement. The intention of the injection program is to fill the mine voids in the north lobe of the Omega Mine (an area where most of the acidity is believed to be generated) with the grout, thus reducing the contact of air and water with potentially acidic material. The grout mix design consists of an approximate 1:1 ratio of fly ash to byproducts from fluidized bed combustion. Approximately 100 gallons of water per cubic yard of grout is used to help achieve flowability. Observation of the mine workings via subsurface borings and downhole video camera operation confirmed that first-mined areas were generally open while second-mined areas were generally partially collapsed. Closer injection hole spacing was used in second-mined areas to account for collapsed workings. The construction documents have been prepared with the project being bid in late 1997. The engineer`s cost estimate was approximately $2,500,000, with the low bid of approximately $2,300,000 being submitted by Howard Concrete Pumping of Bridgeville, PA.« less

Abscesses of the frontal lobe of the brain secondary to covert dental sepsis.

PubMed

Ingham, H R; Kalbag, R M; Tharagonnet, D; High, A S; Sengupta, R P; Selkon, J B

1978-09-02

The bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. Subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. This evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways.

Prediction of inspiratory flow shapes during sleep with a mathematic model of upper airway forces.

PubMed

Aittokallio, Tero; Gyllenberg, Mats; Saaresranta, Tarja; Polo, Olli

2003-11-01

To predict the airflow dynamics during sleep using a mathematic model that incorporates a number of static and dynamic upper airway forces, and to compare the numerical results to clinical flow data recorded from patients with sleep-disordered breathing on and off various treatment options. Upper airway performance was modeled in virtual subjects characterized by parameter settings that describe common combinations of risk factors predisposing to upper airway collapse during sleep. The treatments effect were induced by relevant changes of the initial parameter values. Computer simulations at our website (http://www.utu.fi/ml/sovmat/bio/). Risk factors considered in the simulation settings were sex, obesity, pharyngeal collapsibility, and decreased phasic activity of pharyngeal muscles. The effects of weight loss, pharyngeal surgery, nasal continuous positive airway pressure, and respiratory stimulation on the inspiratory flow characteristics were tested with the model. Numerical predictions were investigated by means of 3 measurable inspiratory airflow characteristics: initial slope, total volume, and flow shape. The model was able to reproduce the inspiratory flow shape characteristics that have previously been described in the literature. Simulation results also supported the observations that a multitude of factors underlie the pharyngeal collapse and, therefore, certain medical therapies that are effective in some conditions may prove ineffective in others. A mathematic model integrating the current knowledge of upper airway physiology is able to predict individual treatment responses. The model provides a framework for designing novel and potentially feasible treatment alternatives for sleep-disordered breathing.

Sequential occurrence of combined pulmonary fibrosis and emphysema syndrome in a non-smoker female patient.

PubMed

Gupta, Pawan; Dash, Devijyoti; Mittal, Richa; Chhabra, Sunil K

2017-05-01

The combined pulmonary fibrosis and emphysema (CPFE) syndrome is a unique and an under-recognized disorder characterized by emphysema in the upper lobes and interstitial fibrosis in the lower lobes of the lung. It occurs predominantly in males and almost exclusively in smokers. This rare combination of a restrictive and an obstructive mechanical defect carries a poorer prognosis than either of the two components. We present a case of CPFE syndrome in a non-smoker female patient who developed lower lobe emphysema subsequent to development of interstitial fibrosis. The case was remarkable for the extreme rarity of several presenting features, namely, a lower lobe occurrence of emphysema subsequent to pre-existent interstitial fibrosis, female gender and absence of a history of smoking. © 2015 John Wiley & Sons Ltd.

Is the lymphatic drainage of lung cancer lobe-specific? A surgical appraisal.

PubMed

Riquet, Marc; Rivera, Caroline; Pricopi, Ciprian; Arame, Alex; Mordant, Pierre; Foucault, Christophe; Dujon, Antoine; Le Pimpec-Barthes, Françoise

2015-03-01

Nowadays, early-stage lung cancers are more frequently encountered. Selective lymph node (LN) dissection based on lobe-specific lymphatic pathway has been proposed. Our aim was to study nodal involvement according to tumour location. We reviewed 1779 lobectomized patients and analysed their pathological characteristics according to tumour location: Group 1 (G1), right upper lobe; Group 2 (G2), right middle lobe; Group 3 (G3), right lower lobe; Group 4 (G4), left upper division; Group 5 (G5), lingula; Group 6 (G6), left lower lobe. The pN status was recorded for each group to analyse the lymphatic spread of non-small-cell lung cancer (NSCLC) according to tumour location. The numbers and proportions of lobectomies in each group were 613 patients in G1 (59.2%), 64 in G2 (6.4%), 359 in G3 (34.6%), 404 in G4 (54.3%), 54 in G5 (7.3%) and 286 in G6 (38.4%). The rates of pN2 involvement were similar, whatever the group was, even when deciphering single- and multistation diseases. on the right side, single-station N2 disease was mainly found in the superior mediastinum (SM) for G1 (95%), and in the inferior for G3 (90%). On the left side, single-station N2 was mainly found in the SM in G4 (94%), and the inferior in G6 (48%). Whatever the side, in case of two-station involvement, both mediastina were concerned in 40% (in G4) to 81% of the case (in G3). Long-term survival rates were different in skip metastasis, single- and multistation involvement, but not between lobes. Tumour location is not a predictor of nodal metastasis pattern. In surgical treatment of NSCLC, complete systematic mediastinal LN dissection remains the only acceptable procedure from an oncological point of view. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Dosimetric evaluation of the feasibility of stereotactic body radiotherapy for primary lung cancer with lobe-specific selective elective nodal irradiation.

PubMed

Komatsu, Tetsuya; Kunieda, Etsuo; Kitahara, Tadashi; Akiba, Takeshi; Nagao, Ryuta; Fukuzawa, Tsuyoshi

2016-01-01

More than 10% of all patients treated with stereotactic body radiotherapy (SBRT) for primary lung cancer develop regional lymph node recurrence. We evaluated the dosimetric feasibility of SBRT with lobe-specific selective elective nodal irradiation (ENI) on dose-volume histograms. A total of 21 patients were treated with SBRT for Stage I primary lung cancer between January 2010 and June 2012 at our institution. The extents of lobe-specific selective ENI fields were determined with reference to prior surgical reports. The ENI fields included lymph node stations (LNS) 3 + 4 + 11 for the right upper lobe tumors, LNS 7 + 11 for the right middle or lower lobe tumors, LNS 5 + 11 for the left upper lobe tumors, and LNS 7 + 11 for the left lower lobe tumors. A composite plan was generated by combining the ENI plan and the SBRT plan and recalculating for biologically equivalent doses of 2 Gy per fraction, using a linear quadratic model. The V20 of the lung, D(1cm3) of the spinal cord, D(1cm3) and D(10cm3) of the esophagus and D(10cm3) of the tracheobronchial wall were evaluated. Of the 21 patients, nine patients (43%) could not fulfill the dose constraints. In all these patients, the distance between the planning target volume (PTV) of ENI (PTVeni) and the PTV of SBRT (PTVsrt) was ≤2.0 cm. Of the three patients who developed regional metastasis, two patients had isolated lymph node failure, and the lymph node metastasis was included within the ENI field. When the distance between the PTVeni and PTVsrt is >2.0 cm, SBRT with selective ENI may therefore dosimetrically feasible. © The Author 2015. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

Sensitization of Upper Airway Mechanoreceptors as a New Pharmacologic Principle to Treat Obstructive Sleep Apnea: Investigations with AVE0118 in Anesthetized Pigs

PubMed Central

Wirth, Klaus J.; Steinmeyer, Klaus; Ruetten, Hartmut

2013-01-01

Study Objectives: Drug treatment for obstructive sleep apnea (OSA) is desirable because at least 30% of patients do not tolerate continuous positive airway pressure (CPAP) treatment. The negative pressure reflex (NPR) involving superficially located mechanoreceptors in the upper airway (UA) is an important mechanism for UA patency inhibitable by topical UA anesthesia (lidocaine). The NPR may serve as a target for pharmacological intervention for a topical treatment of OSA. The objective was to determine the effect of pharmacological augmentation of the NPR on UA collapsibility. Design: We developed a model of UA collapsibility in which application of negative pressures caused UA collapses in spontaneously breathing α-chloralose-urethane anesthetized pigs as indicated by characteristic tracheal pressure and air flow changes. Setting: N/A. Patients or Participants: N/A. Interventions: N/A. Measurements and Results: The potassium channel blocker AVE0118 administered topically to the UA in doses of 1, 3, and 10 mg per nostril sensitized the NPR, shifting the mechanoreceptor response threshold for the genioglossus muscle to more positive pressures (P < 0.001; n = 6 per group) and dose-dependently inhibited UA collapsibility. Ten mg of AVE0118 prevented UA collapses against negative pressures of -150 mbar (P < 0.01) for > 4 h in all pigs, while in control pigs the UA collapsed at -50 mbar or less negative pressures. The effect of AVE0118 was abolished by UA lidocaine anesthesia. Acute intravenous administration of naloxone or acetazolamide was ineffective; paroxetine and mirtazepine were weakly effective and fluoxetine was moderately effective in line with reported clinical efficacy. Conclusion: Topical administration of AVE0118 to the UA is a promising pharmacologic approach for the treatment of OSA. Citation: Wirth KJ; Steinmeyer K; Ruetten H. Sensitization of upper airway mechanoreceptors as a new pharmacologic principle to treat obstructive sleep apnea: investigations with AVE0118 in anesthetized pigs. SLEEP 2013;36(5):699-708. PMID:23633752

The collapse of pelagic fishes in the upper San Francisco estuary

USGS Publications Warehouse

Sommer, T.; Armor, C.; Baxter, R.; Breuer, R.; Brown, L.; Chotkowski, M.; Culberson, S.; Feyrer, F.; Gingras, M.; Herbold, B.; Kimmerer, W.; Mueller-Solger, A.; Nobriga, M.; Souza, K.

2007-01-01

Although the pelagic fish community of the upper San Francisco Estuary historically has shown substantial variability, a recent collapse has captured the attention of resource managers, scientists, legislators, and the general public. The ecological and management consequences of the decline are most serious for delta smelt (Hypomesus transpacificus), a threatened species whose narrow range overlaps with large water diversions that supply water to over 25 million people. The decline occurred despite recent moderate hydrology, which typically results in at least modest recruitment, and investments of hundreds of millions of dollars in habitat restoration and environmental water allocations to support native fishes. In response to the pelagic fish collapse, an ambitious multi-agency research team has been working since 2005 to evaluate the causes of the decline, which likely include a combination of factors: stock-recruitment effects, a decline in habitat quality, increased mortality rates, and reduced food availability due to invasive species.

Limits on low-energy neutrino fluxes with the Mont Blanc liquid scintillator detector

NASA Astrophysics Data System (ADS)

Aglietta, M.; Antonioli, P.; Badino, G.; Bologna, G.; Castagnoli, C.; Castellina, A.; Dadykin, V. L.; Fulgione, W.; Galeotti, P.; Khalchukov, F. F.; Korolkova, E. V.; Kortchaguin, P. V.; Kortchaguin, V. B.; Kudryavtsev, V. A.; Malguin, A. S.; Periale, L.; Ryassny, V. G.; Ryazhskaya, O. G.; Saavedra, O.; Trinchero, G.; Vernetto, S.; Yakushev, V. F.; Zatsepin, G. T.

1992-11-01

The LSD liquid scintillation detector has been operating since 1985 as an underground neutrino observatory in the Mont Blanc Laboratory with the main objective of detecting antineutrino bursts from collapsing stars. In August 1988 the construction of an additional lead and borex paraffin shield considerably reduced the radioactive background and increased the sensitivity of the apparatus. In this way the search for steady fluxes of low-energy neutrinos of different flavours through their interactions with free protons and carbon nuclei of the scintillator was made possible. No evidence for a galactic collapse was observed during the whole period of measurement. The corresponding 90% c.l. upper limit on the galactic collapses rate is 0.45 y -1 for a burst duration of ΔT ⩽ 10 s. After analysing the last 3 years data, the following 90% c.l. upper limits on the steady neutrino and antineutrino fluxes were obtained:

Constructing a patient-specific computer model of the upper airway in sleep apnea patients.

PubMed

Dhaliwal, Sandeep S; Hesabgar, Seyyed M; Haddad, Seyyed M H; Ladak, Hanif; Samani, Abbas; Rotenberg, Brian W

2018-01-01

The use of computer simulation to develop a high-fidelity model has been proposed as a novel and cost-effective alternative to help guide therapeutic intervention in sleep apnea surgery. We describe a computer model based on patient-specific anatomy of obstructive sleep apnea (OSA) subjects wherein the percentage and sites of upper airway collapse are compared to findings on drug-induced sleep endoscopy (DISE). Basic science computer model generation. Three-dimensional finite element techniques were undertaken for model development in a pilot study of four OSA patients. Magnetic resonance imaging was used to capture patient anatomy and software employed to outline critical anatomical structures. A finite-element mesh was applied to the volume enclosed by each structure. Linear and hyperelastic soft-tissue properties for various subsites (tonsils, uvula, soft palate, and tongue base) were derived using an inverse finite-element technique from surgical specimens. Each model underwent computer simulation to determine the degree of displacement on various structures within the upper airway, and these findings were compared to DISE exams performed on the four study patients. Computer simulation predictions for percentage of airway collapse and site of maximal collapse show agreement with observed results seen on endoscopic visualization. Modeling the upper airway in OSA patients is feasible and holds promise in aiding patient-specific surgical treatment. NA. Laryngoscope, 128:277-282, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold.

PubMed

Eckert, Danny J; Malhotra, Atul; Wellman, Andrew; White, David P

2014-04-01

The effect of common sedatives on upper airway physiology and breathing during sleep in obstructive sleep apnea (OSA) has been minimally studied. Conceptually, certain sedatives may worsen OSA in some patients. However, sleep and breathing could improve with certain sedatives in patients with OSA with a low respiratory arousal threshold. This study aimed to test the hypothesis that trazodone increases the respiratory arousal threshold in patients with OSA and a low arousal threshold. Secondary aims were to examine the effects of trazodone on upper airway dilator muscle activity, upper airway collapsibility, and breathing during sleep. Patients were studied on 4 separate nights according to a within-subjects cross-over design. Sleep physiology laboratory. Seven patients with OSA and a low respiratory arousal threshold. In-laboratory polysomnograms were obtained at baseline and after 100 mg of trazodone was administered, followed by detailed overnight physiology experiments under the same conditions. During physiology studies, continuous positive airway pressure was transiently lowered to measure arousal threshold (negative epiglottic pressure prior to arousal), dilator muscle activity (genioglossus and tensor palatini), and upper airway collapsibility (Pcrit). Trazodone increased the respiratory arousal threshold by 32 ± 6% (-11.5 ± 1.4 versus -15.3 ± 2.2 cmH2O, P < 0.01) but did not alter the apnea-hypopnea index (39 ± 12 versus 39 ± 11 events/h sleep, P = 0.94). Dilator muscle activity and Pcrit also did not systematically change with trazodone. Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold without major impairment in dilator muscle activity or upper airway collapsibility. However, the magnitude of change in arousal threshold was insufficient to overcome the compromised upper airway anatomy in these patients.

Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome.

PubMed

Shah, Ashok; Gera, Kamal; Panjabi, Chandramani

2016-01-01

Allergic bronchopulmonary aspergillosis (ABPA) is infrequently documented in children with asthma. Although collapse is not uncommon, middle lobe syndrome (MLS) as a presentation of ABPA is rather a rarity. A 9-year-old female child with asthma presented with increase in intensity of symptoms along with a right midzone patchy consolidation on a chest radiograph. In addition, an ill-defined opacity abutting the right cardiac border with loss of cardiac silhouette was noted. A right lateral view confirmed a MLS, which was further corroborated by high resolution computed tomography. Central bronchiectasis was also observed, which prompted a work-up for ABPA. The child met 7/8 major diagnostic criteria for ABPA. She was then initiated on oral prednisolone that resulted in a marked clinical improvement within a fortnight. Radiological clearance occurred at 3 months with inflation of the middle lobe. ABPA presenting with MLS in a child is yet to be reported. A high index of suspicion is required to establish the diagnosis of ABPA in a child presenting with MLS. This would obviate the invasive investigations usually done to ascertain the cause of MLS.

Preserving lung after traumatic transection of left lower lobe bronchus from bullet injury.

PubMed

Hanif, Muhammad Shoaib; Mishwani, A H; Oparka, J; Buchan, K

2015-06-01

A 22-year-old soldier was shot in the left chest by a bullet from close range. He was found to have a left haemothorax and remained shocked despite aggressive resuscitation. Due to difficult terrain and night time movement restrictions, there were limitations to the transfer of patient. So he was attended at a peripheral hospital. At emergency thoracotomy, three segmental arteries to left upper lobe were ligated and haemostasis was secured. The level of transection of left lower lobe bronchus was identified to be below the origin of the apical segmental bronchus. The lower lobe bronchus was successfully re-attached and followed up with a daily bronchoscopic clearance of distal airway. The patient made a full recovery. Anastomosis of left lower lobe bronchus after traumatic transection is a viable option for preserving an amputated lobe, in trauma settings, provided haemostatic control has been adequately achieved. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Effects of Cascaded Voltage Collapse and Protection of Many Induction Machine Loads upon Load Characteristics Viewed from Bulk Transmission System

NASA Astrophysics Data System (ADS)

Kumano, Teruhisa

As known well, two of the fundamental processes which give rise to voltage collapse in power systems are the on load tap changers of transformers and dynamic characteristics of loads such as induction machines. It has been well established that, comparing among these two, the former makes slower collapse while the latter makes faster. However, in realistic situations, the load level of each induction machine is not uniform and it is well expected that only a part of loads collapses first, followed by collapse process of each load which did not go into instability during the preceding collapses. In such situations the over all equivalent collapse behavior viewed from bulk transmission level becomes somewhat different from the simple collapse driven by one aggregated induction machine. This paper studies the process of cascaded voltage collapse among many induction machines by time simulation, where load distribution on a feeder line is modeled by several hundreds of induction machines and static impedance loads. It is shown that in some cases voltage collapse really cascades among induction machines, where the macroscopic load dynamics viewed from upper voltage level makes slower collapse than expected by the aggregated load model. Also shown is the effects of machine protection of induction machines, which also makes slower collapse.

Radiation characteristics of a source in a thin substrate mounted over a dielectric medium

NASA Technical Reports Server (NTRS)

Engheta, Nader; Elachi, Charles

1988-01-01

The radiation pattern of a line source is calculated for the case in which the source is lying on the top or the bottom surface of a lossless dielectric substrate that is mounted on the top of semiinfinite dielectric medium. It is found that in both cases the pattern along the interfaces has a null; that the pattern in the upper semiinfinite medium has a single lobe; and that the pattern in the lower semiinfinite medium has many lobes, the number of which varies with the substrate thickness. In both cases, the power radiated into the lower medium is more than that radiated into the upper medium. Applications of this calculation to remote sensing, microstrip antenna technology, and antenna arrays are discussed.

Effect of Sleeping Position on Upper Airway Patency in Obstructive Sleep Apnea Is Determined by the Pharyngeal Structure Causing Collapse.

PubMed

Marques, Melania; Genta, Pedro R; Sands, Scott A; Azarbazin, Ali; de Melo, Camila; Taranto-Montemurro, Luigi; White, David P; Wellman, Andrew

2017-03-01

In some patients, obstructive sleep apnea (OSA) can be resolved with improvement in pharyngeal patency by sleeping lateral rather than supine, possibly as gravitational effects on the tongue are relieved. Here we tested the hypothesis that the improvement in pharyngeal patency depends on the anatomical structure causing collapse, with patients with tongue-related obstruction and epiglottic collapse exhibiting preferential improvements. Twenty-four OSA patients underwent upper airway endoscopy during natural sleep to determine the pharyngeal structure associated with obstruction, with simultaneous recordings of airflow and pharyngeal pressure. Patients were grouped into three categories based on supine endoscopy: Tongue-related obstruction (posteriorly located tongue, N = 10), non-tongue related obstruction (collapse due to the palate or lateral walls, N = 8), and epiglottic collapse (N = 6). Improvement in pharyngeal obstruction was quantified using the change in peak inspiratory airflow and minute ventilation lateral versus supine. Contrary to our hypothesis, patients with tongue-related obstruction showed no improvement in airflow, and the tongue remained posteriorly located while lateral. Patients without tongue involvement showed modest improvement in airflow (peak flow increased 0.07 L/s and ventilation increased 1.5 L/min). Epiglottic collapse was virtually abolished with lateral positioning and ventilation increased by 45% compared to supine position. Improvement in pharyngeal patency with sleeping position is structure specific, with profound improvements seen in patients with epiglottic collapse, modest effects in those without tongue involvement and-unexpectedly-no effect in those with tongue-related obstruction. Our data refute the notion that the tongue falls back into the airway during sleep via gravitational influences. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

Effect of Sleeping Position on Upper Airway Patency in Obstructive Sleep Apnea Is Determined by the Pharyngeal Structure Causing Collapse

PubMed Central

Genta, Pedro R.; Sands, Scott A.; Azarbazin, Ali; de Melo, Camila; Taranto-Montemurro, Luigi; White, David P.; Wellman, Andrew

2017-01-01

Abstract Objectives: In some patients, obstructive sleep apnea (OSA) can be resolved with improvement in pharyngeal patency by sleeping lateral rather than supine, possibly as gravitational effects on the tongue are relieved. Here we tested the hypothesis that the improvement in pharyngeal patency depends on the anatomical structure causing collapse, with patients with tongue-related obstruction and epiglottic collapse exhibiting preferential improvements. Methods: Twenty-four OSA patients underwent upper airway endoscopy during natural sleep to determine the pharyngeal structure associated with obstruction, with simultaneous recordings of airflow and pharyngeal pressure. Patients were grouped into three categories based on supine endoscopy: Tongue-related obstruction (posteriorly located tongue, N = 10), non-tongue related obstruction (collapse due to the palate or lateral walls, N = 8), and epiglottic collapse (N = 6). Improvement in pharyngeal obstruction was quantified using the change in peak inspiratory airflow and minute ventilation lateral versus supine. Results: Contrary to our hypothesis, patients with tongue-related obstruction showed no improvement in airflow, and the tongue remained posteriorly located while lateral. Patients without tongue involvement showed modest improvement in airflow (peak flow increased 0.07 L/s and ventilation increased 1.5 L/min). Epiglottic collapse was virtually abolished with lateral positioning and ventilation increased by 45% compared to supine position. Conclusions: Improvement in pharyngeal patency with sleeping position is structure specific, with profound improvements seen in patients with epiglottic collapse, modest effects in those without tongue involvement and—unexpectedly—no effect in those with tongue-related obstruction. Our data refute the notion that the tongue falls back into the airway during sleep via gravitational influences. PMID:28329099

Large rock avalanches in southern Perù: the Cerro Caquilluco - Cerrillos Negros rock slide - avalanche (Tacna, Tomasiri, Perù)

NASA Astrophysics Data System (ADS)

Crosta, G.; Hermanns, R. L.; Murillo, P. V.

2012-04-01

The Andean bent which coincides with the Peruvian-Chilean border region is characterised by one of the largest relief contrasts on earth with depth of the subduction trench ranging from 5000 to 6000 m below sea level and mountain tops ranging from 5500 to 6300 m a.s.l.. The western flank of the Andes is subdivided in 4 major geologic zones (i.e. Coastal Cordillera, longitudinal Basin or depression, the Precordillera or western escarpment and western Cordillera). Local relief contrasts are also pronounced due to the incision of deep canyons into several million old uplifted surfaces, preserved because of the extremely dry climate with precipitation averaging a few mm and less per year. The Lluta collapse (minimum age of 2.5 Ma; volume 26 km3) is one of the largest non-volcanic non-marine landslides on Earth and has been mapped in that area (Wörner et al., 2002). Systematic mapping in northern Chile and Southern Peru has revealed that this is not the only gigantic landslide in the area but that further landslides of similar size occurred in the area, located both along the canyon slopes and along the western escarpment of the Cordillera. This suggests that landsliding has been a major factor in controlling erosion. This contribution describes first results on mapping a giant landslide complex in southern Perù called the Cerro Caquilluco - Cerrillos Negros Tomasiri rock slide - avalanche complex. The systematic mapping we have carried out in the area is presented in a further contribution to this conference. The Cerro Caquilluco - Cerrillos Negros Tomasiri rock slide - avalanche complex affected the upper part of a SW dipping paleosurface (8° to 9°) cut by a disconnected and regular primitive drainage network organized in a series of SW trending parallel valleys. This network developed within the lower Miocene pinkish tuffaceous deposits of the Huaylillas formation, whereas the main landslide scarp lies within the conglomerates of the Upper Moquegua formation (lower Oligocene). The same type of landscape is found to the southeast of Tacna and Arica (Huaylillas anticline, Oxaya anticline and Sucuna homocline) The Cerro Caquilluco - Cerrillos Negros Tomasiri rock slide - avalanche complex has a total length of about 43 km, a source area width and length of about 4 km and 5.1 km, respectively. The computed fahrböschung is equal to 4.6° with an H/L ratio of about 0.08 and resulting in an extremely large excessive travel distance. The H/L value is well below the expected value computed according to the classical (H/L) vs volume empirical relationships presented in the literature. Deposition occurred along most of the transportation area and is evidenced by a series of wide lobes (10 to 65 m high) and levees (from a few meters to some tens of meters high) with an average extent of 8 km transversally to the flow direction. Flow structures are visible all over the transportation area and several lobes can be mapped out. Presently, we cannot determine if most of these failures belong to a consequent large retrogressive event or to different events separated in time. The longest lobe has only pristine morphology in the most distal part of the accumulation area. Here the deposit is represented by a unique tongue shaped deposit, 11 km long, 3 km wide and 25 to 60 m thick (rough volume estimate 1.15 km3) ), deposited along the piedmont surface (ave. slope: 2°). This deposit presents a series of features typical of rock avalanches deposited on regular smooth surfaces, like: lateral levees, longitudinal and transversal ridges and furrows. The extreme runout of this failure could be explained assuming a single failure event or the detachment from a part of the slope located well below the present day upper scarp. In the middle part of the deposition/transportation area few lateral levees are preserved and deep valleys have been eroded into the deposit. Considering the relationship with the piedmont deposits and the faults cutting through the area the deposit could be up to 2-2.3 Ma old. The morphology of this lower lobe is contrasting to the upper lobes which smooth out the landscape. The minimum volume involved in the giant rockslide-avalanche complex amounts to about 9 km3. The headscarp area is affected by smaller and likely younger rock avalanche lobes overlying the more massive rock-avalanche lobe complex. These features are well preserved also to the west of the main slide complex, along the E-W trending high scarp cutting the old paleosurface, where more pristine rock avalanche lobes with more blocky surfaces overlie older lobes characterized by a smooth topography cut by high scarps. Conditioning factors of the slope instabilities could have been: the SW dipping of weak formations (tuffs and conglomerates), the presence of ENE trending sinistral faults offsetting the primitive drainage network close to the headscarp, the intense seismicity and/or a wetter climate, the continuous uplift (min. 0.04-0.3 mm/yr). This area is less than 230 km away from the subduction trench and magnitude 7 to 9 earthquakes occur on average every 100 years on the subduction segment. Megathrust earthquakes are quite common in the area on geological time scales and no big landslides of that site has been reported during multiple historic subduction earthquakes in southern Peru and northern Chile. Some results concerning slope stability analyses and runout modelling are presented to support possible failure mechanisms and to understand the exceptional avalanche mobility.

Rare coexistence of sarcoidosis and lung adenocarcinoma.

PubMed

Kachalia, Amit Girish; Ochieng, Pius; Kachalia, Kinjal; Rahman, Habibur

2014-01-01

An eighty year old African-American female was evaluated for cough, chest pain, asymptomatic anemia and 21 pound weight loss over a six month period. Computerized tomography (CT) revealed a spiculated 2.8 cm right upper lobe lung nodule, other smaller nodules and lymphadenopathy. Gallium scan revealed abnormal uptake of radiotracer in lacrimal, hilar and mediastinal glands. Broncho-alveolar lavage showed CD4/CD8 ratio of 2:1 with 15% lymphocytes. Biopsy of right upper lobe lesion and mediastinoscopic lymph node biopsy showed numerous matured uniform non-caseating granulomatous inflammation, however stains and culture for Acid fast bacilli (AFB)/fungal organisms were negative. Patient improved on oral steroids. Six months later she returned with worsening dyspnea and chest X-ray showed bilateral pleural effusions. Thoracocentesis revealed Thyroid transcription factor 1 (TTF1) positive adenocarcinoma cells and Video assisted thoracic surgery (VATS) procedure revealed numerous pleural, pericardial, diaphragmatic metastasis. Biopsy also was positive for TTF1 adenocarcinoma and positive for Epidermal Growth Factor receptor (EGFR) mutation, however negative for Anaplastic Lymphoma Kinase (ALK). Talc pleurodesis was performed. She was treated with erlotinib while steroid was kept on hold. Initial tumor burden decreased but follow-up PET scan six months later showed progression of tumor with lymphadenopathy. After discussion with patient and family, patient opted for hospice care. Oncocentric theory postulates sarcoidosis as an immunological reaction to dispersal of tumor antigen. Sarcocentric theory postulates that cell-mediated immune abnormalities induced by sarcoidosis in CD4 and CD8 cells is involved in the onset of lung cancer. Thus considerable controversy exists regarding sarcoidosis and malignancy. In our case, TTF1 adenocarcinoma cells from thoracocentesis suggest peripheral nodules in right upper lobe and lingula were likely metastatic, presenting as malignant pleural effusions. However if noncaseating granulomatous inflammation is expected as an immunological reaction to tumor antigen, it is very interesting to observe that initial tissue biopsy of primary right upper lobe mass and mediastinal lymph nodes showed matured uniform non-caseating granulomatous inflammation and no evidence of adenocarcinoma. This being said, it would be highly unlikely for sarcoidosis to progress to lung adenocarcinoma within six months. This adds further controversy to whether granulomatous inflammation is a precursor to future malignancy or whether this elderly African-American female was predisposed to develop granulomatous inflammation in presence of a tumor antigen. One can also speculate whether repeat tissue sampling from right upper lobe mass would have shown granulomatous inflammation or TTF1 adenocarcinoma. While evidence is still lacking regarding association between sarcoidosis and lung adenocarcinoma, it is important for clinicians to exclude metastatic malignancy in patients exhibiting clinical and radiographic findings consistent with sarcoidosis.

Synchronized imaging and acoustic analysis of the upper airway in patients with sleep-disordered breathing.

PubMed

Chang, Yi-Chung; Huon, Leh-Kiong; Pham, Van-Truong; Chen, Yunn-Jy; Jiang, Sun-Fen; Shih, Tiffany Ting-Fang; Tran, Thi-Thao; Wang, Yung-Hung; Lin, Chen; Tsao, Jenho; Lo, Men-Tzung; Wang, Pa-Chun

2014-12-01

Progressive narrowing of the upper airway increases airflow resistance and can produce snoring sounds and apnea/hypopnea events associated with sleep-disordered breathing due to airway collapse. Recent studies have shown that acoustic properties during snoring can be altered with anatomic changes at the site of obstruction. To evaluate the instantaneous association between acoustic features of snoring and the anatomic sites of obstruction, a novel method was developed and applied in nine patients to extract the snoring sounds during sleep while performing dynamic magnetic resonance imaging (MRI). The degree of airway narrowing during the snoring events was then quantified by the collapse index (ratio of airway diameter preceding and during the events) and correlated with the synchronized acoustic features. A total of 201 snoring events (102 pure retropalatal and 99 combined retropalatal and retroglossal events) were recorded, and the collapse index as well as the soft tissue vibration time were significantly different between pure retropalatal (collapse index, 2 ± 11%; vibration time, 0.2 ± 0.3 s) and combined (retropalatal and retroglossal) snores (collapse index, 13 ± 7% [P ≤ 0.0001]; vibration time, 1.2 ± 0.7 s [P ≤ 0.0001]). The synchronized dynamic MRI and acoustic recordings successfully characterized the sites of obstruction and established the dynamic relationship between the anatomic site of obstruction and snoring acoustics.

Catastrophic lava dome failure at Soufrière Hills Volcano, Montserrat, 12-13 July 2003

USGS Publications Warehouse

Herd, Richard A.; Edmonds, Marie; Bass, Venus A.

2005-01-01

The lava dome collapse of 12–13 July 2003 was the largest of the Soufrière Hills Volcano eruption thus far (1995–2005) and the largest recorded in historical times from any volcano; 210 million m3 of dome material collapsed over 18 h and formed large pyroclastic flows, which reached the sea. The evolution of the collapse can be interpreted with reference to the complex structure of the lava dome, which comprised discrete spines and shear lobes and an apron of talus. Progressive slumping of talus for 10 h at the beginning of the collapse generated low-volume pyroclastic flows. It undermined the massive part of the lava dome and eventually prompted catastrophic failure. From 02:00 to 04:40 13 July 2003 large pyroclastic flows were generated; these reached their largest magnitude at 03:35, when the volume flux of material lost from the lava dome probably approached 16 million m3 over two minutes. The high flux of pyroclastic flows into the sea caused a tsunami and a hydrovolcanic explosion with an associated pyroclastic surge, which flowed inland. A vulcanian explosion occurred during or immediately after the largest pyroclastic flows at 03:35 13 July and four further explosions occurred at progressively longer intervals during 13–15 July 2003. The dome collapse lasted approximately 18 h, but 170 of the total 210 million m3 was removed in only 2.6 h during the most intense stage of the collapse.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wicks, Christopher Donald; Madin, Mark Michael

A cam carrier assembly includes a cylinder head having valves and a camshaft having lobes. A cam carrier has a first side coupled with the cylinder head engaging around the valves and a second side with bearing surfaces supporting the camshaft. A series of apertures extend between the first and second sides for the lobes to interface with the valves. The cam carrier is made of carbon fiber composite insulating the camshaft from the cylinder head and providing substantial weight reduction to an upper section of an associated engine.

[Normal lung volumes in patients with idiopathic pulmonary fibrosis and emphysema].

PubMed

Casas, Juan Pablo; Abbona, Horacio; Robles, Adriana; López, Ana María

2008-01-01

Pulmonary function tests in idiopathic pulmonary fibrosis characteristically show a restrictive pattern, resulting from reduction of pulmonary compliance due to diffuse fibrosis. Conversely, an obstructive pattern with hyperinflation results in emphysema by loss of elastic recoil, expiratory collapse of the peripheral airways and air trapping. Previous reports suggest that when both diseases coexist, pulmonary volumes are compensated and a smaller than expected reduction or even normal lung volumes can be found. We report 4 male patients of 64, 60, 73 and 70 years, all with heavy cigarette smoking history and progressive breathlessness. Three of them had severe limitation in their quality of life. All four showed advanced lung interstitial involvement, at high resolution CT scan, fibrotic changes predominantly in the subpleural areas of lower lung fields and concomitant emphysema in the upper lobes. Emphysema and pulmonary fibrosis was confirmed by open lung biopsy in one patient. The four patients showed normal spirometry and lung volumes with severe compromise of gas exchange and poor exercise tolerance evaluated by 6 minute walk test. Severe pulmonary arterial hypertension was also confirmed in three patients. Normal lung volumes does not exclude diagnosis of idiopathic pulmonary fibrosis in patients with concomitant emphysema. The relatively preserved lung volumes may underestimate the severity of idiopathic pulmonary fibrosis and attenuate its effects on lung function parameters.

Observations of obsidian lava flow emplacement at Puyehue-Cordón Caulle, Chile

NASA Astrophysics Data System (ADS)

Tuffen, H.; Castro, J. M.; Schipper, C. I.; James, M. R.

2012-04-01

The dynamics of obsidian lava flow emplacement remain poorly understood as active obsidian lavas are seldom seen. In contrast with well-documented basaltic lavas, we lack observational data on obsidian flow advance and temporal evolution. The ongoing silicic eruption at Puyehue-Cordón Caulle volcanic complex (PCCVC), southern Chile provides an unprecedented opportunity to witness and study obsidian lava on the move. The eruption, which started explosively on June 4th 2011, has since June 20 generated an active obsidian flow field that remains active at the time of writing (January 2012), with an area of ~6 km2, and estimated volume of ~0.18 km3. We report on observations, imaging and sampling of the north-western lava flow field on January 4th and 10th 2012, when vent activity was characterised by near-continuous ash venting and Vulcanian explosions (Schipper et al, this session) and was simultaneously feeding the advancing obsidian flow (Castro et al, this session). On January 4th the north-western lava flow front was characterised by two dominant facies: predominant rubbly lava approximately 30-40 m thick and mantled by unstable talus aprons, and smoother, thinner lobes of more continuous lava ~50 m in length that extended roughly perpendicular to the overall flow direction, forming lobes that protrude from the flow margin, and lacked talus aprons. The latter lava facies closely resembled squeeze-up structures in basaltic lava flows[1] and appeared to originate from and overlie the talus apron of the rubbly lava. Its upper surface consisted of smooth, gently folded lava domains cut by crevasse-like tension gashes. During ~2 hours of observation the squeeze-up lava lobe was the most frequent location of small-volume rockfalls, which occurred at ~1-10 minute intervals from the flow front and indicated a locus of lava advance. On January 10th the squeeze-up lava lobes had evolved significantly, with disruption and breakage of smooth continuous lava surfaces to form blocky lava domains. Gravitational collapse of lobe toes had created an incipient talus apron that had markedly advanced. In contrast, the rubbly lava had undergone only modest evolution, reflecting continued rockfall and subtle advance of its well-developed talus apron. Visualisation of the lava morphology and evolution was assisted by 3D models of the lava flow front, produced by an automated photo-reconstruction technique (SfM-MVS, a combination of structure from motion and multi-view stereo algorithms), and >1000 digital images taken at the scene. Additionally samples were collected from the rubbly lava and squeeze-up lava lobe facies. Sample textures, geochemistry and volatile concentrations will provide further insight into the evolving physical and chemical state of the lava. Our observations indicate that endogenous growth plays a major role in obsidian lava flow advance, with effective thermal insulation of lava that emerges from squeeze-ups close to the flow margin. This has important implications for the longevity, mobility and hazard potential of obsidian flows and indicates striking similarities with the dynamics of basaltic lava flow emplacement. [1]Applegarth L.J. et al. 2010 Bull. Volcanol. 72, 641-656.

Mapping a lateralization gradient within the ventral stream for auditory speech perception.

PubMed

Specht, Karsten

2013-01-01

Recent models on speech perception propose a dual-stream processing network, with a dorsal stream, extending from the posterior temporal lobe of the left hemisphere through inferior parietal areas into the left inferior frontal gyrus, and a ventral stream that is assumed to originate in the primary auditory cortex in the upper posterior part of the temporal lobe and to extend toward the anterior part of the temporal lobe, where it may connect to the ventral part of the inferior frontal gyrus. This article describes and reviews the results from a series of complementary functional magnetic resonance imaging studies that aimed to trace the hierarchical processing network for speech comprehension within the left and right hemisphere with a particular focus on the temporal lobe and the ventral stream. As hypothesized, the results demonstrate a bilateral involvement of the temporal lobes in the processing of speech signals. However, an increasing leftward asymmetry was detected from auditory-phonetic to lexico-semantic processing and along the posterior-anterior axis, thus forming a "lateralization" gradient. This increasing leftward lateralization was particularly evident for the left superior temporal sulcus and more anterior parts of the temporal lobe.

Mapping a lateralization gradient within the ventral stream for auditory speech perception

PubMed Central

Specht, Karsten

2013-01-01

Recent models on speech perception propose a dual-stream processing network, with a dorsal stream, extending from the posterior temporal lobe of the left hemisphere through inferior parietal areas into the left inferior frontal gyrus, and a ventral stream that is assumed to originate in the primary auditory cortex in the upper posterior part of the temporal lobe and to extend toward the anterior part of the temporal lobe, where it may connect to the ventral part of the inferior frontal gyrus. This article describes and reviews the results from a series of complementary functional magnetic resonance imaging studies that aimed to trace the hierarchical processing network for speech comprehension within the left and right hemisphere with a particular focus on the temporal lobe and the ventral stream. As hypothesized, the results demonstrate a bilateral involvement of the temporal lobes in the processing of speech signals. However, an increasing leftward asymmetry was detected from auditory–phonetic to lexico-semantic processing and along the posterior–anterior axis, thus forming a “lateralization” gradient. This increasing leftward lateralization was particularly evident for the left superior temporal sulcus and more anterior parts of the temporal lobe. PMID:24106470

Dawn LAMO Image 158

NASA Image and Video Library

2016-08-25

An area along the rim of the crater at the center of this view from NASA Dawn spacecraft, has collapsed, producing a lobe-shaped feature where the material settled. The image is centered at approximately 52 degrees north latitude, 316 degrees east longitude. NASA's Dawn spacecraft took this image on May 28, 2016, from its low-altitude mapping orbit, at a distance of about 240 miles (385 kilometers) above the surface of Ceres. The image resolution is 120 feet (35 meters) per pixel. http://photojournal.jpl.nasa.gov/catalog/PIA20880

Did mud contribute to freeway collapse?

NASA Astrophysics Data System (ADS)

Hough, Susan E.; Friberg, Paul A.; Busby, Robert; Field, Edward F.; Jacob, Klaus H.; Borcherdt, Roger D.

At least 41 people were killed October 17 when the upper tier of the Nimitz Freeway in Oakland, Calif., collapsed during the Ms = 7.1 Loma Prieta earthquake. Seismologists studying aftershocks concluded that soil conditions and resulting ground motion amplification were important in the failure of the structure and should be considered in the reconstruction of the highway.Structural design weaknesses in the two-tiered freeway, known as the Cypress structure, had been identified before the tragedy. The seismologists, from Lamont Doherty Geological Observatory in Palisades, N.Y., and the U.S. Geological Survey in Menlo Park, Calif., found that the collapsed section was built on fill over Bay mud. A southern section of the Cypress structure built on alluvium of Quaternary age did not collapse (see Figure 1).

Seismic geomorphology of the Lobed-channel System of Upper Miocene Huangliu Formation, Yinggehai Basin, Northwestern South China Sea

NASA Astrophysics Data System (ADS)

Liu, H.

2016-02-01

Three-dimensional seismic data have been widely used in interpreting ancient river systems and their associated sediment deposits. Thin-bed reservoirs of lobed-channel system in lithostratigraphic units of Dongfang (DF) area are one of the major study areas for reservoir growth in the Yinggehai basin of northwestern South China Sea. Although it is understood that the transport mechanics of parent substrate and alluvium determine the morphology of channel for lobed-channel system, the transport mechanism and regional gradient are relatively poorly understood. This study is focused on the application of various techniques in seismic geomorphology to the Yinggehai Basin at paleo-water-depth of 120m to assess influences of regional gradient and relative sea level change on lobed-channel palaeogeomorphology in shallow-water environments. The Vietnam paleo-Blue River, which located at south of modern Red River, flowed through DF area and transported turbidity deposit to DF area in the coastal environment. In 3-D seismic survey area, four fifth-order sequences in first member of upper Miocene Huangliu formation were identified using well and seismic data. Seismic inversion and 90° phasing of seismic data were used to convert seismic traces to pseudolithologic logs. Stratal slicing made it possible to interpolate and extrapolate well-data-derived sequence and identify submarine fan, channel fill, lobes and overbank deposit. Strata slices suggested that sea-floor slopes exerted main influence on channel morphology. Specifically, DF13-1 block had high gradient, which mainly distributed mud-sand-rich lobes. However, DF13-2 block established low gradient, which mostly indicated sand-rich braided channels. The values of sinuosity, channel widths, meander-belt widths in DF13-2 block are all greater than these in DF13-1 block. In addition, results of carbon isotope measurements and foraminiferal research of two blocks suggest that paleo sea level in DF13-2 block (30m 150m) was higher than that of DF13-1 block (20m 90m). It also deciphered why channels in DF13-2 incised deeply because of the stronger hydrodynamic energy in the shallow-water environments. Thus DF13-2 block was formed in a lobed-channel and sand rich system, compared with DF13-1 of channelized-lobes and mud-sand rich system.

Distribution and characteristics of amphibole asbestos fibres, measured with the light microscope, in the left lung of an insulation worker.

PubMed Central

Morgan, A; Holmes, A

1983-01-01

Concentrations of uncoated and coated amphibole fibres were measured postmortem in samples taken from the periphery of both upper and lower lobes of the left lung of an insulation worker. Similar measurements were made on a more limited range of samples from elsewhere in the lung and on a hilar lymph node. The mean concentration of uncoated fibres in the upper lobe was twice that in the lower. Significant differences were observed in the mean concentration of uncoated fibres in different regions of the periphery, the diaphragmatic region having the lowest value. Variations in the concentrations of both uncoated and coated fibres in the costal region of the lower lobe may have been related to the effect of rib structures on ventilation. Concentrations of fibrous and non-fibrous dust were well correlated in the peripheral samples. The length distributions of uncoated and coated fibres were also measured and differences detected in fibres from the various regions of the lung. This work emphasises the care required in sampling lung tissue in order to obtain representative material for the determination of fibre concentration. PMID:6824599

Partial anomalous left pulmonary artery: report of two cases and review of literature.

PubMed

Sen, Supratim; Winlaw, David S; Sholler, Gary F

2015-06-01

We describe two cases of anomalous origin of the left lower-lobe pulmonary artery from the right pulmonary artery. The primary diagnosis was mitral atresia, hypoplastic left ventricle, aortic arch hypoplasia in the first child, and tetralogy of Fallot in the second. In both cases, the pulmonary trunk gave rise to a left pulmonary artery in the normal position. In addition, a second branch of the left pulmonary artery arose from the right pulmonary artery, and passed posterior and inferior to the left main or upper-lobe bronchus to supply the left lower lobe. In this review, we compare our findings with previously reported examples of this extremely rare cardiac malformation, and discuss possible embryological explanations for the lesion.

Monitoring crater-wall collapse at active volcanoes: a study of the 12 January 2013 event at Stromboli

NASA Astrophysics Data System (ADS)

Calvari, Sonia; Intrieri, Emanuele; Di Traglia, Federico; Bonaccorso, Alessandro; Casagli, Nicola; Cristaldi, Antonio

2016-05-01

Crater-wall collapses are fairly frequent at active volcanoes and they are normally studied through the analysis of their deposits. In this paper, we present an analysis of the 12 January 2013 crater-wall collapse occurring at Stromboli volcano, investigated by means of a monitoring network comprising visible and infrared webcams and a Ground-Based Interferometric Synthetic Aperture Radar. The network revealed the triggering mechanisms of the collapse, which are comparable to the events that heralded the previous effusive eruptions in 1985, 2002, 2007 and 2014. The collapse occurred during a period of inflation of the summit cone and was preceded by increasing explosive activity and the enlargement of the crater. Weakness of the crater wall, increasing magmastatic pressure within the upper conduit induced by ascending magma and mechanical erosion caused by vent opening at the base of the crater wall and by lava fingering, are considered responsible for triggering the collapse on 12 January 2013 at Stromboli. We suggest that the combination of these factors might be a general mechanism to generate crater-wall collapse at active volcanoes.

Volcano collapse promoted by hydrothermal alteration and edifice shape, Mount Rainier, Washington

USGS Publications Warehouse

Reid, M.E.; Sisson, T.W.; Brien, D.L.

2001-01-01

Catastrophic collapses of steep volcano flanks threaten many populated regions, and understanding factors that promote collapse could save lives and property. Large collapses of hydrothermally altered parts of Mount Rainier have generated far-traveled debris flows; future flows would threaten densely populated parts of the Puget Sound region. We evaluate edifice collapse hazards at Mount Rainier using a new three-dimensional slope stability method incorporating detailed geologic mapping and subsurface geophysical imaging to determine distributions of strong (fresh) and weak (altered) rock. Quantitative three-dimensional slope stability calculations reveal that sizeable flank collapse (>0.1 km3) is promoted by voluminous, weak, hydrothermally altered rock situated high on steep slopes. These conditions exist only on Mount Rainier's upper west slope, consistent with the Holocene debris-flow history. Widespread alteration on lower flanks or concealed in regions of gentle slope high on the edifice does not greatly facilitate collapse. Our quantitative stability assessment method can also provide useful hazard predictions using reconnaissance geologic information and is a potentially rapid and inexpensive new tool for aiding volcano hazard assessments.

Seismicity associated with dome growth and collapse at the Soufriere Hills Volcano, Montserrat

USGS Publications Warehouse

Miller, A.D.; Stewart, R.C.; White, R.A.; Luckett, R.; Baptie, B.J.; Aspinall, W.P.; Latchman, J.L.; Lynch, L.L.; Voight, B.

1998-01-01

Varied seismicity has accompanied growth and collapse of the lava dome of the Soufriere Hills Volcano, Montserrat. Earthquakes have been classified as either volcano-tectonic, long-period or hybrid, and daily variations in the numbers of events have mapped changes in the style of eruption. Repetitive hybrid earthquakes were common during the first months of dome growth. In July 1996 the style of seismicity changed and regular short-lived hybrid earthquake swarms became common. This change was probably caused by an increase in the magma flux. Earthquake swarms have preceded almost all major dome collapses, and have accompanied cyclical deformation, thought to be due to a built-up of pressure in the upper conduit which is later released by magma moving into the dome.Varied seismicity has accompanied growth and collapse of the lava dome of the Soufriere Hills Volcano, Montserrat. Earthquakes have been classified as either volcano-tectonic, long-period or hybrid, and daily variations in the numbers of events have mapped changes in the style of eruption. Repetitive hybrid earthquakes were common during the first months of dome growth. In July 1996 the style of seismicity changed and regular, short-lived hybrid earthquake swarms became common. This change was probably caused by an increase in the magma flux. Earthquake swarms have preceded almost all major dome collapses, and have accompanied cyclical deformation, thought to be due to a build-up of pressure in the upper conduit which is later released by magma moving into the dome.

Use of endobronchial valve insertion to treat relapsing pneumothorax: a case report and literature review.

PubMed

Qi, Fei; Tian, Qing; Chen, Liang'an; Li, Chunyan; Zhang, Shu; Liu, Xingchen; Xiao, Binbin

2017-07-01

Backgorund and Aims: Unidirectional endobronchial valves have recently been shown to be beneficial as treatment for persistent air leaks. This report presents a first case of endobronchial valve implantation to treat relapsing pneumothorax in a Chinese patient, and also presents a review of the literature on the use of one-way valve insertion for the treatment of persistent air leaks. The patient did undergo a recent but failed chest tube intervention. By bronchoscopy and using Chartis® system measurements, the upper left lobe (including the left apical bronchus) was closed using a catheter. After the expected decrease in airflow following bronchial occlusion, increased air pressure and decreased spilled air were noted; it was concluded that the pneumothorax was located in the left upper lobe. A Zephyr ® endobronchial valve was placed in the left upper apical bronchus. The health benefits of the procedure were noticed in the following days. Our review suggests that the use of endobronchial valves could be used as an effective, minimally invasive, low-risk intervention for patients with pneumothorax that cannot be treated surgically. © 2015 John Wiley & Sons Ltd.

Poster — Thur Eve — 62: A Retrospective Assessment of the Prevalence and Dosimetric Effect of Lateral Electron Disequilibrium in a Population of Lung Cancer Patients Treated by Stereotactic Body Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Disher, Brandon; Wade, Laura; Hajdok, George

2014-08-15

Stereotactic Body Radiation Therapy (SBRT) is a treatment option for early stage non-small cell lung cancer (NSCLC). SBRT uses tightly conformed megavoltage (MV) x-ray beams to ablate the tumour. However, small MV x-ray fields may produce lateral electron disequilibrium (LED) within lung tissue, which can reduce the dose to tumour. The goal of this work is to estimate the prevalence of LED in NSCLC patients treated with SBRT, and determine dose effects for patients prone or averse to LED. Thirty NSCLC patients were randomly selected for analysis. 4-dimensional CT lung images were segmented into the right and left upper andmore » lower lobes (RUL, RLL, LUL, LLL), and the right middle lobe. Dose calculations were performed using volume-modulated arc therapy in the Pinnacle{sup 3} TPS. Most tumours were located in the upper lobes (RUL 53%, LUL 27%) where density was significantly lower (RUL −808±46 HU vs. RLL −743±71 HU; LUL −808 ±56 HU vs. LLL −746±70 HU; p<0.001). In general, the prevalence of LED increased with higher beam energy. Using 6MV photons, patients with a RUL tumour experienced moderate (81 %), and mild (19%) levels of LED. At 18MV, LED became more prominent with severe (50%) and moderate (50%) LED exhibited. Dosimetrically, for patients prone to LED, poorer target coverage (i.e. increased R100 by 20%) and improved lung sparing (i.e. reduced V20 by −46%) was observed. The common location of lung cancers in the upper lobes, coupled with lower lung density, results in the potential occurrence of LED, which may underdose the tumour.« less

Heating of trapped ultracold atoms by collapse dynamics

NASA Astrophysics Data System (ADS)

Laloë, Franck; Mullin, William J.; Pearle, Philip

2014-11-01

The continuous spontaneous localization (CSL) theory alters the Schrödinger equation. It describes wave-function collapse as a dynamical process instead of an ill-defined postulate, thereby providing macroscopic uniqueness and solving the so-called measurement problem of standard quantum theory. CSL contains a parameter λ giving the collapse rate of an isolated nucleon in a superposition of two spatially separated states and, more generally, characterizing the collapse time for any physical situation. CSL is experimentally testable, since it predicts some behavior different from that predicted by standard quantum theory. One example is the narrowing of wave functions, which results in energy imparted to particles. Here we consider energy given to trapped ultracold atoms. Since these are the coldest samples under experimental investigation, it is worth inquiring how they are affected by the CSL heating mechanism. We examine the CSL heating of a Bose-Einstein condensate (BEC) in contact with its thermal cloud. Of course, other mechanisms also provide heat and also particle loss. From varied data on optically trapped cesium BECs, we present an energy audit for known heating and loss mechanisms. The result provides an upper limit on CSL heating and thereby an upper limit on the parameter λ . We obtain λ ≲1 (±1 ) ×10-7 s-1.

Diversity waves in collapse-driven population dynamics

DOE PAGES

Maslov, Sergei; Sneppen, Kim

2015-09-14

Populations of species in ecosystems are often constrained by availability of resources within their environment. In effect this means that a growth of one population, needs to be balanced by comparable reduction in populations of others. In neutral models of biodiversity all populations are assumed to change incrementally due to stochastic births and deaths of individuals. Here we propose and model another redistribution mechanism driven by abrupt and severe collapses of the entire population of a single species freeing up resources for the remaining ones. This mechanism may be relevant e.g. for communities of bacteria, with strain-specific collapses caused e.g.more » by invading bacteriophages, or for other ecosystems where infectious diseases play an important role. The emergent dynamics of our system is cyclic ‘‘diversity waves’’ triggered by collapses of globally dominating populations. The population diversity peaks at the beginning of each wave and exponentially decreases afterwards. Species abundances are characterized by a bimodal time-aggregated distribution with the lower peak formed by populations of recently collapsed or newly introduced species while the upper peak - species that has not yet collapsed in the current wave. In most waves both upper and lower peaks are composed of several smaller peaks. This self-organized hierarchical peak structure has a long-term memory transmitted across several waves. It gives rise to a scale-free tail of the time-aggregated population distribution with a universal exponent of 1.7. We show that diversity wave dynamics is robust with respect to variations in the rules of our model such as diffusion between multiple environments, species-specific growth and extinction rates, and bet-hedging strategies.« less

Diversity waves in collapse-driven population dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maslov, Sergei; Sneppen, Kim

Populations of species in ecosystems are often constrained by availability of resources within their environment. In effect this means that a growth of one population, needs to be balanced by comparable reduction in populations of others. In neutral models of biodiversity all populations are assumed to change incrementally due to stochastic births and deaths of individuals. Here we propose and model another redistribution mechanism driven by abrupt and severe collapses of the entire population of a single species freeing up resources for the remaining ones. This mechanism may be relevant e.g. for communities of bacteria, with strain-specific collapses caused e.g.more » by invading bacteriophages, or for other ecosystems where infectious diseases play an important role. The emergent dynamics of our system is cyclic ‘‘diversity waves’’ triggered by collapses of globally dominating populations. The population diversity peaks at the beginning of each wave and exponentially decreases afterwards. Species abundances are characterized by a bimodal time-aggregated distribution with the lower peak formed by populations of recently collapsed or newly introduced species while the upper peak - species that has not yet collapsed in the current wave. In most waves both upper and lower peaks are composed of several smaller peaks. This self-organized hierarchical peak structure has a long-term memory transmitted across several waves. It gives rise to a scale-free tail of the time-aggregated population distribution with a universal exponent of 1.7. We show that diversity wave dynamics is robust with respect to variations in the rules of our model such as diffusion between multiple environments, species-specific growth and extinction rates, and bet-hedging strategies.« less

Relative prevalence of upper respiratory tract obstructive disorders in two breeds of harness racehorses (185 cases: 1998-2006).

PubMed

Strand, E; Fjordbakk, C T; Sundberg, K; Spangen, L; Lunde, H; Hanche-Olsen, S

2012-09-01

Two genetically and phenotypically distinct horse breeds are used for harness racing in Scandinavia: the Standardbred (SB) and Coldblooded Trotter. These racehorses have identical environmental, management and racing conditions. Therefore, this study was undertaken to identify and compare the relative prevalence of upper respiratory tract (URT) obstructive disorders in these 2 breeds. To determine whether these 2 phenotypically different breeds of harness racehorses have different predispositions for URT disorders. Retrospective study of 88 Norwegian Coldblooded Trotters (NCT) and 97 SBs referred to this hospital for URT evaluation between 1998 and 2006. Case records of all horses diagnosed with an URT disorder during resting endoscopy, and all horses undergoing high-speed treadmill videoendoscopy (HSTV) with one or more periods of induced poll flexion were evaluated. The relative prevalence of URT disorders between the 2 breeds was analysed using a Fisher's exact test. There was a significant (P<0.05) breed predisposition regarding 6 URT disorders. Bilateral dynamic laryngeal collapse associated with poll flexion and flaccid epiglottis was significantly more frequent in the NCT. Alar fold collapse and nasopharyngeal collapse were significantly more frequent in SBs. Epiglottic entrapment and nasal flutter were only diagnosed in the SBs. Dynamic disorders were more common than resting disorders in both breeds. URT obstructive disorders (dynamic laryngeal collapse associated with poll flexion, flaccid epiglottis, pharyngeal collapse, alar fold collapse, nasal flutter and epiglottic entrapment) are breed related, indicating an anatomic or functional cause. Periods of induced poll flexion during HSTV was essential to declare harness racehorses free of URT disorders. Further anatomic or physiological studies comparing these breeds could potentially provide insight into the pathogenesis of certain URT obstructive disorders. Induced poll flexion should be included in routine HSTV examinations of all harness racehorses. © 2011 EVJ Ltd.

Latest Pleistocene advance and collapse of the Matanuska - Knik glacier system, Anchorage Lowland, southern Alaska

NASA Astrophysics Data System (ADS)

Kopczynski, Sarah E.; Kelley, Samuel E.; Lowell, Thomas V.; Evenson, Edward B.; Applegate, Patrick J.

2017-01-01

At the end of the last ice age, glacier systems worldwide underwent dramatic retreat. Here, we document the advance and retreat of a glacier system with adjacent marine- and land-based components during the latter part of the Termination. We utilize three lines of evidence: lithologic provenance, geomorphic mapping, and radiocarbon ages derived from lake cores to reconstruct glacier extent and timing of advance and retreat within our study area centered at N 61.50°, W 149.50°, just north of Anchorage, Alaska. Two glaciers, sourced in the Talkeetna and Chugach Mountains, flowed down the Matanuska and Knik Valleys forming a coalesced lobe that advanced onto the Anchorage Lowlands and terminated at Elmendorf Moraine. We use the presence of lithologies unique to the Matanuska catchment in glacial drift to delineate the paleoflow lines and to estimate the suture line of the two glacier systems. The eastern side of the lobe, attributed to ice flow from the Knik Valley, was in contact with elevated marine waters within the Knik Arm fjord, and thus retreat was likely dominated by calving. Geomorphic evidence suggests the western side of the lobe, attributed to ice flow from Matanuska Valley, retreated due to stagnation. We constrain retreat of the combined Matanuska and Knik lobe with thirteen new radiocarbon ages, in addition to previously published radiocarbon ages, and with geomorphic evidence suggesting the retreat occurred in two phases. Retreat from the Elmendorf Moraine began between 16.8 and 16.4 ka BP. A second, faster retreat phase occurred later and was completed by 13.7 ka BP. With the 140 km of total retreat occurring over ∼3000 years or less. This pattern of glacial advance and retreats agrees well with the deglacial histories from the southern sectors of the Cordilleran Ice Sheet, as well as many other alpine glacier systems in the western U.S. and northern Alaska. This consistent behavior of glacier systems may indicate that climate oscillated over western North America early in deglaciation before it was recorded in other proxies such as ice cores. Furthermore, the period in which we note mountain glacier collapse in northwestern North America is synchronous with the worldwide glacial termination raising questions about intrahemispheric linkages.

Evolution of Post-accretion-induced Collapse Binaries: The Effect of Evaporation

NASA Astrophysics Data System (ADS)

Liu, Wei-Min; Li, Xiang-Dong

2017-12-01

Accretion-induced collapse (AIC) is widely accepted to be one of the formation channels for millisecond pulsars (MSPs). Since the MSPs have high spin-down luminosities, they can immediately start to evaporate their companion stars after birth. In this paper, we present a detailed investigation on the evolution of the post-AIC binaries, taking into account the effect of evaporation both before and during the Roche-lobe overflow process. We discuss the possible influence of the input parameters including the evaporation efficiency, the initial spin period, and the initial surface magnetic field of the newborn neutron star. We compare the calculated results with the traditional low-mass X-ray binary evolution and suggest that they may reproduce at least part of the observed redbacks and black widows in the companion mass–orbital period plane depending on the mechanisms of angular momentum loss associated with evaporation.

Time of day affects the frequency and duration of breathing events and the critical closing pressure during NREM sleep in participants with sleep apnea.

PubMed

El-Chami, Mohamad; Shaheen, David; Ivers, Blake; Syed, Ziauddin; Badr, M Safwan; Lin, Ho-Sheng; Mateika, Jason H

2015-09-15

We investigated if the number and duration of breathing events coupled to upper airway collapsibility were affected by the time of day. Male participants with obstructive sleep apnea completed a constant routine protocol that consisted of sleep sessions in the evening (10 PM to 1 AM), morning (6 AM to 9 AM), and afternoon (2 PM to 5 PM). On one occasion the number and duration of breathing events was ascertained for each sleep session. On a second occasion the critical closing pressure that demarcated upper airway collapsibility was determined. The duration of breathing events was consistently greater in the morning compared with the evening and afternoon during N1 and N2, while an increase in event frequency was evident during N1. The critical closing pressure was increased in the morning (2.68 ± 0.98 cmH2O) compared with the evening (1.29 ± 0.91 cmH2O; P ≤ 0.02) and afternoon (1.25 ± 0.79; P ≤ 0.01). The increase in the critical closing pressure was correlated to the decrease in the baseline partial pressure of carbon dioxide in the morning compared with the afternoon and evening (r = -0.73, P ≤ 0.005). Our findings indicate that time of day affects the duration and frequency of events, coupled with alterations in upper airway collapsibility. We propose that increases in airway collapsibility in the morning may be linked to an endogenous modulation of baseline carbon dioxide levels and chemoreflex sensitivity (12), which are independent of the consequences of sleep apnea.

Improved Noninterferometric Test of Collapse Models Using Ultracold Cantilevers

NASA Astrophysics Data System (ADS)

Vinante, A.; Mezzena, R.; Falferi, P.; Carlesso, M.; Bassi, A.

2017-09-01

Spontaneous collapse models predict that a weak force noise acts on any mechanical system, as a consequence of the collapse of the wave function. Significant upper limits on the collapse rate have been recently inferred from precision mechanical experiments, such as ultracold cantilevers and the space mission LISA Pathfinder. Here, we report new results from an experiment based on a high-Q cantilever cooled to millikelvin temperatures, which is potentially able to improve the current bounds on the continuous spontaneous localization (CSL) model by 1 order of magnitude. High accuracy measurements of the cantilever thermal fluctuations reveal a nonthermal force noise of unknown origin. This excess noise is compatible with the CSL heating predicted by Adler. Several physical mechanisms able to explain the observed noise have been ruled out.

Devonian salt dissolution-collapse breccias flooring the Cretaceous Athabasca oil sands deposit and development of lower McMurray Formation sinkholes, northern Alberta Basin, Western Canada

NASA Astrophysics Data System (ADS)

Broughton, Paul L.

2013-01-01

The sub-Cretaceous paleotopography underlying giant Lower Cretaceous Athabasca oil sands, northern Alberta, has an orthogonal lattice pattern of troughs up to 50 km long and 100 m deep between pairs of cross-cutting lineaments. These structures are interpreted to have been inherited from a similar pattern of dissolution collapse-subsidence troughs in the underlying Middle Devonian salt beds. Removal of more than 100 m of halite salt fragmented the overlying Upper Devonian strata into fault blocks and collapse breccias that subsided into the underlying dissolution troughs. The unusually low 1:2 to 1:3 thickness ratios of halite salts to the overlying strata resulted in the Upper Devonian strata collapse-subsidence into underlying salt dissolution troughs being more cataclysmic during the first phase of salt removal. The second phase of slower but complete salt removal between the earlier troughs resulted in a more gradual subsidence of the overlying strata. This obliterated the earlier pattern of giant cross-cutting dissolution troughs bounded by major lineaments. The collapse breccia fabrics underlying the earlier troughs differ from those from areas between the troughs. Collapse breccias underlying the large troughs often have crushed fabrics distributed in zones that rapidly pinched out between fault blocks. Breccias between troughs developed as giant mosaics of detached carbonate blocks that formed breccia pipe complexes. Multiple sinkholes up to 100 m deep aligned along multi-km linear valley trends that dissected the sub-Cretaceous paleotopography. These sinkhole trends formed orthogonal patterns inherited from underlying lattice of NW-SE and NE-SW salt structured lineaments. These cross-cutting sinkhole trends have a smaller 5 km scale reticulate pattern similar to the giant 50 km scale pattern of collapse-subsidence troughs. Other sinkholes developed as lower McMurray strata sagged when underlying Devonian fault blocks and breccia pipes differentially subsided.

Distal turbidite fan/lobe succession of the Late Oligocene Zuberec Fm. - architecture and hierarchy (Central Western Carpathians, Orava-Podhale basin)

NASA Astrophysics Data System (ADS)

Starek, Dušan; Fuksi, Tomáš

2017-08-01

A part of the Upper Oligocene sand-rich turbidite systems of the Central Carpathian Basin is represented by the Zuberec Formation. Sand/mud-mixed deposits of this formation are well exposed in the northern part of the basin, allowing us to interpret the turbidite succession as terminal lobe deposits of a submarine fan. This interpretation is based on the discrimination of three facies associations that are comparable to different components of distributive lobe deposits in deep-water fan systems. They correspond to the lobe off-axis, lobe fringe and lobe distal fringe depositional subenvironments, respectively. The inferences about the depositional paleoenvironment based on sedimentological observations are verified by statistical analyses. The bed-thickness frequency distributions and vertical organization of the facies associations show cyclic trends at different hierarchical levels that enable us to reconstruct architectural elements of a turbidite fan. First, small-scale trends correspond with shift in the lobe element centroid between successive elements. Differences in the distribution and frequency of sandstone bed thicknesses as well as differences in the shape of bed-thickness frequency distributions between individual facies associations reflect a gradual fining and thinning in a down-dip direction. Second, meso-scale trends are identified within lobes and they generally correspond to the significant periodicity identified by the time series analysis of the bed thicknesses. The meso-scale trends demonstrate shifts in the position of the lobe centroid within the lobe system. Both types of trends have a character of a compensational stacking pattern and could be linked to autogenic processes. Third, a largescale trend documented by generally thickening-upward stacking pattern of beds, accompanied by a general increase of the sandstones/mudstones ratio and by a gradual change of percentage of individual facies, could be comparable to lobe-system scale. This trend probably indicates a gradual basinward progradation of lobe system controlled by allogenic processes related to tectonic activity of sources and sea-level fluctuations.

Environmental Impact Study of the Northern Section of the Upper Mississippi River. Pool 4.

DTIC Science & Technology

1973-11-01

our feet, the valley between the two barren hills, through which the Mississippi winds in numerous channels, formed many beautiful islands, as far as...retreated and formed the 4/I ’I •~o or - w - i- -’ I. HEWITT PHASE T. ROIX PHASE A - . Hibbing CFe. i S Aulot- 40-,’ -4 a b 3 AUTMBA -4 PINE CITY - jfA...the Des Moines Lobe and I c~avanced northeastward across the recent deposits of the Superior Lobe. It formed the Pine City Moraine at its terminus (Fig

Tensile strength of 67P/Churyumov-Gerasimenko nucleus material from overhangs

NASA Astrophysics Data System (ADS)

Attree, N.; Groussin, O.; Jorda, L.; Nébouy, D.; Thomas, N.; Brouet, Y.; Kührt, E.; Preusker, F.; Scholten, F.; Knollenberg, J.; Hartogh, P.; Sierks, H.; Barbieri, C.; Lamy, P.; Rodrigo, R.; Koschny, D.; Rickman, H.; Keller, H. U.; A'Hearn, M. F.; Auger, A.-T.; Barucci, M. A.; Bertaux, J.-L.; Bertini, I.; Bodewits, D.; Boudreault, S.; Cremonese, G.; Da Deppo, V.; Davidsson, B.; Debei, S.; De Cecco, M.; Deller, J.; El-Maarry, M. R.; Fornasier, S.; Fulle, M.; Gutiérrez, P. J.; Güttler, C.; Hviid, S.; Ip, W.-H.; Kovacs, G.; Kramm, J. R.; Küppers, M.; Lara, L. M.; Lazzarin, M.; Lopez Moreno, J. J.; Lowry, S.; Marchi, S.; Marzari, F.; Mottola, S.; Naletto, G.; Oklay, N.; Pajola, M.; Toth, I.; Tubiana, C.; Vincent, J.-B.; Shi, X.

2018-03-01

We directly measured twenty overhanging cliffs on the surface of comet 67P/Churyumov-Gerasimenko extracted from the latest shape model and estimated the minimum tensile strengths needed to support them against collapse under the comet's gravity. We find extremely low strengths of around 1 Pa or less (1 to 5 Pa, when scaled to a metre length). The presence of eroded material at the base of most overhangs, as well as the observed collapse of two features andthe implied previous collapse of another, suggests that they are prone to failure and that the true material strengths are close to these lower limits (although we only consider static stresses and not dynamic stress from, for example, cometary activity). Thus, a tensile strength of a few pascals is a good approximation for the tensile strength of the 67P nucleus material, which is in agreement with previous work. We find no particular trends in overhang properties either with size over the 10-100 m range studied here or location on the nucleus. There are no obvious differences, in terms of strength, height or evidence of collapse, between the populations of overhangs on the two cometary lobes, suggesting that 67P is relatively homogenous in terms of tensile strength. Low material strengths are supportive of cometary formation as a primordial rubble pile or by collisional fragmentation of a small body (tens of km).

Characteristic microwave background distortions from collapsing domain wall bubbles

NASA Technical Reports Server (NTRS)

Goetz, Guenter; Noetzold, Dirk

1990-01-01

The magnitude and angular pattern of distortions of the microwave background are analyzed by collapsing spherical domain walls. A characteristic pattern of redshift distortions of red or blue spikes surrounded by blue discs was found. The width and height of a spike is related to the diameter and magnitude of the disc. A measurement of the relations between these quantities thus can serve as an unambiguous indicator for a collapsing spherical domain wall. From the redshift distortion in the blue discs an upper bound was found on the surface energy density of the walls sigma is less than or approximately 8 MeV cubed.

Molecular Testing in Multiple Synchronous Lung Adenocarcinomas: Case Report and Literature Review.

PubMed

Rafael, Oana C; Lazzaro, Richard; Hasanovic, Adnan

2016-02-01

Discovery of driver mutations in pulmonary adenocarcinoma has revolutionized the field of thoracic oncology with major impact on therapy and diagnosis. Testing for EGFR, ALK, and KRAS mutations has become part of everyday practice. We report a case with multiple synchronous primary pulmonary adenocarcinomas in a 72-year-old female with previous history of smoking. The patient presented with cough and bilateral lung ground glass opacities. A positron emission tomography/computed tomography scan showed no activity in mediastinal lymph nodes. She underwent a left upper lobe biopsy and a right upper lobe wedge resection. Pathology revealed 4 morphologically distinct adenocarcinoma foci, suggestive of synchronous primary lung tumors. Molecular testing demonstrated no mutation in the left tumor. Three different driver mutations were present in the right lung tumors: KRAS codon 12 G12D and G12V and EGFR exon 21 L858R mutation, confirming the initial histologic impression. Subsequently, left upper lobe lobectomy showed 3 additional foci of adenocarcinoma with different morphologies, suggestive of synchronous primaries as well. No additional molecular testing was performed. Synchronous pulmonary adenocarcinomas are not uncommon; however, 4 or more synchronous tumors are rare. Distinguishing multiple primary tumors from intrapulmonary metastases is a common problem in thoracic oncology with major implications for staging, prognosis, and treatment. Lung adenocarcinoma subclassification based on predominant and coexisting histologic patterns can greatly facilitate differentiation between intrapulmonary metastases and multiple synchronous tumors. Use of molecular profiling is recommended since it further increases confidence in the diagnostic workup of multiple pulmonary adenocarcinomas and helps guiding therapy. © The Author(s) 2015.

Side-to-Side Tracheobronchoplasty to Reconstruct Complex Congenital Tracheobronchial Stenosis.

PubMed

Ragalie, William S; Chun, Robert H; Martin, Timothy; Ghanayem, Nancy S; Berens, Richard J; Beste, David J; Mitchell, Michael E

2017-08-01

Long segment tracheobronchial stenosis is a rare congenital anomaly that can also occur in combination with abnormal bronchial arborization. Long segment tracheal reconstruction in the setting of a supernumerary bridging bronchus has been reported; however, these repairs can be particularly complex. We present our experience using the bridging bronchus to augment long segment tracheal stenosis with a side-to-side tracheobronchoplasty. Four patients with complex long segment tracheobronchial stenosis involving a bronchus suis (right upper lobe bronchus) and a bridging bronchus presented with refractory respiratory distress requiring urgent tracheal reconstruction. Patient 1 was initially managed with modified slide tracheoplasty and tracheostomy. Patients 2, 3, and 4 were managed with single-stage procedures. All patients underwent definitive long segment tracheobronchoplasty consisting of a side-to-side anastomosis between the bridging bronchus and the right upper lobe bronchus. Age at surgery was 569, 69, 24, and 142 days, respectively. Weight at surgery was 9.3, 4.3, 2.7, and 5.9 kg. All patients were weaned from mechanical ventilation at 84, 13, 47, and 8 days after side-to-side tracheobronchoplasty. All patients were alive and free from tracheostomy at follow-up of 6.7, 3.8, 2.7, and 0.5 years. Side-to-side tracheal reconstruction is feasible in severe cases of long segment tracheal stenosis with a right upper lobe bronchus and a bridging bronchus. This technique can be successfully applied in high-risk patients and in the neonatal period and can provide excellent midterm results. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Integrating health status and survival data: the palliative effect of lung volume reduction surgery.

PubMed

Benzo, Roberto; Farrell, Max H; Chang, Chung-Chou H; Martinez, Fernando J; Kaplan, Robert; Reilly, John; Criner, Gerard; Wise, Robert; Make, Barry; Luketich, James; Fishman, Alfred P; Sciurba, Frank C

2009-08-01

In studies that address health-related quality of life (QoL) and survival, subjects who die are usually censored from QoL assessments. This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem. To determine the effect of lung volume reduction surgery (LVRS) on a composite endpoint consisting of the occurrence of death or a clinically meaningful decline in QoL defined as an increase of at least eight points in the St. George's Respiratory Questionnaire total score from the National Emphysema Treatment Trial. In patients with chronic obstructive pulmonary disease and emphysema randomized to receive medical treatment (n = 610) or LVRS (n = 608), we analyzed the survival to the composite endpoint, the hazard functions and constructed prediction models of the slope of QoL decline. The time to the composite endpoint was longer in the LVRS group (2 years) than the medical treatment group (1 year) (P < 0.0001). It was even longer in the subsets of patients undergoing LVRS without a high risk for perioperative death and with upper-lobe-predominant emphysema. The hazard for the composite event significantly favored the LVRS group, although it was most significant in patients with predominantly upper-lobe emphysema. The beneficial impact of LVRS on QoL decline was most significant during the 2 years after LVRS. LVRS has a significant effect on the composite QoL-survival endpoint tested, indicating its meaningful palliative role, particularly in patients with upper-lobe-predominant emphysema.

The upper airway in sleep-disordered breathing: UA in SDB.

PubMed

Taranto Montemurro, L; Kasai, T

2014-02-01

Sleep disordered breathing (SDB) is a common condition and could be a risk factor for cardiovascular morbidity and mortality. However, the pathogenesis of SDB remains to be elucidated. In general, SDB is divided into two forms, obstructive and central sleep apnea (OSA and CSA, respectively). OSA results from the sleep-related collapse of the upper airway (UA) in association with multiple factors like race, gender, obesity and UA dimensions. CSA primarily results from a fall in PaCO2 to a level below the apnea threshold during sleep through the reflex inhibition of central respiratory drive. It has been reported that UA alterations (i.e., collapse or dilation) can be observed in CSA. This review highlights the roles of the UA in the pathogenesis and pathophysiology of SDB.

A comparative study of Ligophorus uruguayense and L. saladensis (Monogenea: Ancyrocephalidae) from Mugil liza (Teleostei: Mugilidae) in southern Brazil.

PubMed

Marchiori, Natalia C; Pariselle, Antoine; Pereira, Joaber; Agnese, Jean-Francois; Durand, Jean-Dominique; Vanhove, Maarten P M

2015-01-01

Representatives of Ligophorus Euzet et Suriano, 1977 were found on the gills of Mugil liza Valenciennes caught in southern Brazil. They were identified as Ligophorus uruguayense Failla Siquier et Ostrowski de Núñez, 2009 and Ligophorus saladensis Marcotegui et Martorelli, 2009, even though specific identification proved to be difficult due to inconsistencies in some diagnostic features reported for these two species. Therefore, a combined morphological and molecular approach was used to critically review the validity of these species, by means of phase contrast and confocal fluorescence microscopical examination of sclerotised hard parts, and assessing the genetic divergence between L. saladensis, L. uruguayense and their congeners using rDNA sequences. The main morphological differences between the two species relate to the shape of the accessory piece of the penis and the median process of the ventral bar. The accessory piece in L. uruguayense is shorter than in L. saladensis, has a cylindrical, convex upper lobe and straight lower lobe (vs with the distal tip of the lower lobe turning away from the upper lobe in the latter species). The ventral bar has a V-shaped anterior median part in L. uruguayense (vs U-shaped in L. saladensis). The two species are suggested to be part of a species complex together with L. mediterraneus Sarabeev, Balbuena et Euzet, 2005. We recommend to generalise such comparative assessment of species of Ligophorus for a reliable picture of the diversity and diversification mechanisms within the genus, and to make full use of its potential as an additional marker for mullet taxonomy and systematics.

Transient Dynamics Simulation of Airflow in a CT-Scanned Human Airway Tree: More or Fewer Terminal Bronchi?

PubMed Central

Zhang, Baihua; Li, Jianhua; Yue, Yong; Qian, Wei

2017-01-01

Using computational fluid dynamics (CFD) method, the feasibility of simulating transient airflow in a CT-based airway tree with more than 100 outlets for a whole respiratory period is studied, and the influence of truncations of terminal bronchi on CFD characteristics is investigated. After an airway model with 122 outlets is extracted from CT images, the transient airflow is simulated. Spatial and temporal variations of flow velocity, wall pressure, and wall shear stress are presented; the flow pattern and lobar distribution of air are gotten as well. All results are compared with those of a truncated model with 22 outlets. It is found that the flow pattern shows lobar heterogeneity that the near-wall air in the trachea is inhaled into the upper lobe while the center flow enters the other lobes, and the lobar distribution of air is significantly correlated with the outlet area ratio. The truncation decreases airflow to right and left upper lobes and increases the deviation of airflow distributions between inspiration and expiration. Simulating the transient airflow in an airway tree model with 122 bronchi using CFD is feasible. The model with more terminal bronchi decreases the difference between the lobar distributions at inspiration and at expiration. PMID:29333194

FARADAY ROTATION STRUCTURE ON KILOPARSEC SCALES IN THE RADIO LOBES OF CENTAURUS A

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feain, I. J.; Ekers, R. D.; Norris, R. P.

2009-12-10

We present the results of an Australia Telescope Compact Array 1.4 GHz spectropolarimetric aperture synthesis survey of 34 deg{sup 2} centered on Centaurus A-NGC 5128. A catalog of 1005 extragalactic compact radio sources in the field to a continuum flux density of 3 mJy beam{sup -1} is provided along with a table of Faraday rotation measures (RMs) and linear polarized intensities for the 28% of sources with high signal to noise in linear polarization. We use the ensemble of 281 background polarized sources as line-of-sight probes of the structure of the giant radio lobes of Centaurus A. This is themore » first time such a method has been applied to radio galaxy lobes and we explain how it differs from the conventional methods that are often complicated by depth and beam depolarization effects. Assuming a magnetic field strength in the lobes of 1.3 B {sub 1} muG, where B {sub 1} = 1 is implied by equipartition between magnetic fields and relativistic particles, the upper limit we derive on the maximum possible difference between the average RM of 121 sources behind Centaurus A and the average RM of the 160 sources along sightlines outside Centaurus A implies an upper limit on the volume-averaged thermal plasma density in the giant radio lobes of (n{sub e} ) < 5 x 10{sup -5} B {sup -1} {sub 1} cm{sup -3}. We use an RM structure function analysis and report the detection of a turbulent RM signal, with rms sigma{sub RM} = 17 rad m{sup -2} and scale size 0.{sup 0}3, associated with the southern giant lobe. We cannot verify whether this signal arises from turbulent structure throughout the lobe or only in a thin skin (or sheath) around the edge, although we favor the latter. The RM signal is modeled as possibly arising from a thin skin with a thermal plasma density equivalent to the Centaurus intragroup medium density and a coherent magnetic field that reverses its sign on a spatial scale of 20 kpc. For a thermal density of n {sub 1} 10{sup -3} cm{sup -3}, the skin magnetic field strength is 0.8 n {sup -1} {sub 1} muG.« less

The medial temporal lobe—conduit of parallel connectivity: a model for attention, memory, and perception

PubMed Central

Mozaffari, Brian

2014-01-01

Based on the notion that the brain is equipped with a hierarchical organization, which embodies environmental contingencies across many time scales, this paper suggests that the medial temporal lobe (MTL)—located deep in the hierarchy—serves as a bridge connecting supra- to infra—MTL levels. Bridging the upper and lower regions of the hierarchy provides a parallel architecture that optimizes information flow between upper and lower regions to aid attention, encoding, and processing of quick complex visual phenomenon. Bypassing intermediate hierarchy levels, information conveyed through the MTL “bridge” allows upper levels to make educated predictions about the prevailing context and accordingly select lower representations to increase the efficiency of predictive coding throughout the hierarchy. This selection or activation/deactivation is associated with endogenous attention. In the event that these “bridge” predictions are inaccurate, this architecture enables the rapid encoding of novel contingencies. A review of hierarchical models in relation to memory is provided along with a new theory, Medial-temporal-lobe Conduit for Parallel Connectivity (MCPC). In this scheme, consolidation is considered as a secondary process, occurring after a MTL-bridged connection, which eventually allows upper and lower levels to access each other directly. With repeated reactivations, as contingencies become consolidated, less MTL activity is predicted. Finally, MTL bridging may aid processing transient but structured perceptual events, by allowing communication between upper and lower levels without calling on intermediate levels of representation. PMID:25426036

Glacial and nonglacial sediment contributions to Wisconsin episode loess in the Central United States

USGS Publications Warehouse

Grimley, D.A.

2000-01-01

The relative contributions of various glacial and nonglacial sediments to Wisconsin Episode loess units along the lower Illinois and central Mississippi Valleys are estimated on the basis of a comparison of magnetic susceptibility and silt and clay mineralogy. A mathematical method of source area calculation, using four compositional parameters, was guided by current knowledge of the regional glacial history. On the basis of this technique, the Roxana Silt, along the Illinois and Mississippi River Valleys, is composed of significant Superior lobe sediment (35%-40%) as well as Wadena or Des Moines lobe sediment (about 35%). This can account for its high magnetic susceptibility, feldspar content, kaolinite content, and pink hue. Lower Peoria Silt contains about 25%-35% Lake Michigan lobe sediment with reduced contributions of the other sources. After the Mississippi River's diversion (20.4 ka), the supply of Superior, Des Moines, and Wadena lobe sediment was cut off from the Illinois Valley in favor of Lake Michigan lobe sediment (75%- 80% contribution). This major source area shift accounts for higher dolomite and illite contents and a more yellow hue in approximately the upper two-thirds of Peoria Silt in the study area. In loess south of St. Louis, less pronounced compositional shifts occur because Superior lobe sediment was not cut off and because Des Moines lobe, Wadena lobe, and Missouri River sediments, having more intermediate composition, compose 40%-50% of the loess, thereby diluting other source area changes. Nonglacial sediment, from fluvial and periglacial sources, is estimated to compose 10%-40% of loess in both regions.

Lung Volume Reduction After Stereotactic Ablative Radiation Therapy of Lung Tumors: Potential Application to Emphysema

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binkley, Michael S.; Shrager, Joseph B.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California

2014-09-01

Purpose: Lung volume reduction surgery (LVRS) improves dyspnea and other outcomes in selected patients with severe emphysema, but many have excessive surgical risk for LVRS. We analyzed the dose-volume relationship for lobar volume reduction after stereotactic ablative radiation therapy (SABR) of lung tumors, hypothesizing that SABR could achieve therapeutic volume reduction if applied in emphysema. Methods and Materials: We retrospectively identified patients treated from 2007 to 2011 who had SABR for 1 lung tumor, pre-SABR pulmonary function testing, and ≥6 months computed tomographic (CT) imaging follow-up. We contoured the treated lobe and untreated adjacent lobe(s) on CT before and after SABRmore » and calculated their volume changes relative to the contoured total (bilateral) lung volume (TLV). We correlated lobar volume reduction with the volume receiving high biologically effective doses (BED, α/β = 3). Results: 27 patients met the inclusion criteria, with a median CT follow-up time of 14 months. There was no grade ≥3 toxicity. The median volume reduction of the treated lobe was 4.4% of TLV (range, −0.4%-10.8%); the median expansion of the untreated adjacent lobe was 2.6% of TLV (range, −3.9%-11.6%). The volume reduction of the treated lobe was positively correlated with the volume receiving BED ≥60 Gy (r{sup 2}=0.45, P=.0001). This persisted in subgroups determined by high versus low pre-SABR forced expiratory volume in 1 second, treated lobe CT emphysema score, number of fractions, follow-up CT time, central versus peripheral location, and upper versus lower lobe location, with no significant differences in effect size between subgroups. Volume expansion of the untreated adjacent lobe(s) was positively correlated with volume reduction of the treated lobe (r{sup 2}=0.47, P<.0001). Conclusions: We identified a dose-volume response for treated lobe volume reduction and adjacent lobe compensatory expansion after lung tumor SABR, consistent across multiple clinical parameters. These data serve to inform our ongoing prospective trial of stereotactic ablative volume reduction (SAVR) for severe emphysema in poor candidates for LVRS.« less

Exercising upper respiratory videoendoscopic evaluation of 100 nonracing performance horses with abnormal respiratory noise and/or poor performance.

PubMed

Davidson, E J; Martin, B B; Boston, R C; Parente, E J

2011-01-01

Although well documented in racehorses, there is paucity in the literature regarding the prevalence of dynamic upper airway abnormalities in nonracing performance horses. To describe upper airway function of nonracing performance horses with abnormal respiratory noise and/or poor performance via exercising upper airway videoendoscopy. Medical records of nonracing performance horses admitted for exercising evaluation with a chief complaint of abnormal respiratory noise and/or poor performance were reviewed. All horses had video recordings of resting and exercising upper airway endoscopy. Relationships between horse demographics, resting endoscopic findings, treadmill intensity and implementation of head and neck flexion during exercise with exercising endoscopic findings were examined. Dynamic upper airway obstructions were observed in 72% of examinations. Head and neck flexion was necessary to obtain a diagnosis in 21 horses. Pharyngeal wall collapse was the most prevalent upper airway abnormality, observed in 31% of the examinations. Complex abnormalities were noted in 27% of the examinations. Resting laryngeal dysfunction was significantly associated with dynamic arytenoid collapse and the odds of detecting intermittent dorsal displacement of the soft palate (DDSP) during exercise in horses with resting DDSP was only 7.7%. Exercising endoscopic observations were different from the resting observations in 54% of examinations. Dynamic upper airway obstructions were common in nonracing performance horses with respiratory noise and/or poor performance. Resting endoscopy was only helpful in determining exercising abnormalities with recurrent laryngeal neuropathy. This study emphasises the importance of exercising endoscopic evaluation in nonracing performance horses with abnormal respiratory noise and/or poor performance for accurate assessment of dynamic upper airway function. © 2010 EVJ Ltd.

A modeling study of the effect of gravity on airflow distribution and particle deposition in the lung.

PubMed

Asgharian, Bahman; Price, Owen; Oberdörster, Gunter

2006-06-01

Inhalation of particles generated as a result of thermal degradation from fire or smoke, as may occur on spacecraft, is of major health concern to space-faring countries. Knowledge of lung airflow and particle transport under different gravity environments is required to addresses this concern by providing information on particle deposition. Gravity affects deposition of particles in the lung in two ways. First, the airflow distribution among airways is changed in different gravity environments. Second, particle losses by sedimentation are enhanced with increasing gravity. In this study, a model of airflow distribution in the lung that accounts for the influence of gravity was used for a mathematical description of particle deposition in the human lung to calculate lobar, regional, and local deposition of particles in different gravity environments. The lung geometry used in the mathematical model contained five lobes that allowed the assessment of lobar ventilation distribution and variation of particle deposition. At zero gravity, it was predicted that all lobes of the lung expanded and contracted uniformly, independent of body position. Increased gravity in the upright position increased the expansion of the upper lobes and decreased expansion of the lower lobes. Despite a slight increase in predicted deposition of ultrafine particles in the upper lobes with decreasing gravity, deposition of ultrafine particles was generally predicted to be unaffected by gravity. Increased gravity increased predicted deposition of fine and coarse particles in the tracheobronchial region, but that led to a reduction or even elimination of deposition in the alveolar region for coarse particles. The results from this study show that existing mathematical models of particle deposition at 1 G can be extended to different gravity environments by simply correcting for a gravity constant. Controlled studies in astronauts on future space missions are needed to validate these predictions.

Computed Tomography-Guided Methylene Blue Labeling Prior to Thoracoscopic Resection of Small Deeply Placed Pulmonary Nodules. Do We Really Need Palpation?

PubMed

Findik, Gokturk; Demiröz, S Mustafa; Apaydın, Selma Mine Kara; Ertürk, Hakan; Biri, Suzan; Incekara, Funda; Aydogdu, Koray; Kaya, Sadi

2017-08-01

Background  Video-assisted thoracic surgery (VATS) is widely used for thoracic surgery operations, and day by day it becomes routine for the excision of undetermined pulmonary nodules. However, it is sometimes hard to reach millimetric nodules through a VATS incision. Therefore, some additional techniques were developed to reach such nodules little in size and which are settled on a challenging localization. In the literature, coils, hook wires, methylene blue, lipidol, and barium staining, and also ultrasound guidance were described for this aim. Herein we discuss our experience with CT-guided methylene blue labeling of small, deeply located pulmonary nodules just before VATS excision. Method  From April 2013 to October 2016, 11 patients with millimetric pulmonary nodules (average 8, 7 mm) were evaluated in our clinic. For all these patients who had strong predisposing factors for malignancy, an 18F-FDG PET-CT scan was also performed. The patients whose nodules were decided to be excised were consulted the radiology clinic. The favorable patients were taken to CT room 2 hours prior to the operation, and CT-guided methylene blue staining were performed under sterile conditions. Results  Mean nodule size of 11 patients was 8.7 mm (6, 2-12). Mean distance from the visceral pleural surface was 12.7 mm (4-29.3). Four of the nodules were located on the left (2 upper lobes, 2 lower lobes), and seven of them were on the right (four lower lobes, two upper lobes, one middle lobe). The maximum standardized uptake values (SUV max) on 18F-FDG PET/CT scan ranged between 0 and 2, 79. Conclusion  CT-guided methylene blue staining of millimetric deeply located pulmonary nodules is a safe and feasible technique that helps surgeon find these undetermined nodules by VATS technique without any need of digital palpation. Georg Thieme Verlag KG Stuttgart · New York.

Pulmonary Actinomycosis Imitating Lung Cancer on (18)F-FDG PET/CT: A Case Report and Literature Review.

PubMed

Qiu, Lin; Lan, Lianjun; Feng, Yue; Huang, Zhanwen; Chen, Yue

2015-01-01

Here we report a case of 41-year-old man with a soft tissue density mass at right upper lung and palpable abscesses at right upper backside and right wrist. (18)F-fluorodeoxyglucose positron emission tomography/computed tomography demonstrated a 7.8 × 5.0 cm mass with soft-tissue density in the upper lobe of the right lung with high metabolic activity. The infiltrative mass extended to adjacent chest wall soft tissue. Final diagnosis of pulmonary actinomycosis with multiple abscesses was made. The patient responded well to antibiotics treatment.

Upper Airway Collapsibility During REM Sleep in Children with the Obstructive Sleep Apnea Syndrome

PubMed Central

Huang, Jingtao; Karamessinis, Laurie R.; Pepe, Michelle E.; Glinka, Stephen M.; Samuel, John M.; Gallagher, Paul R.; Marcus, Carole L.

2009-01-01

Study Objectives: In children, most obstructive events occur during rapid eye movement (REM) sleep. We hypothesized that children with the obstructive sleep apnea syndrome (OSAS), in contrast to age-matched control subjects, would not maintain airflow in the face of an upper airway inspiratory pressure drop during REM sleep. Design: During slow wave sleep (SWS) and REM sleep, we measured airflow, inspiratory time, inspiratory time/total respiratory cycle time, respiratory rate, tidal volume, and minute ventilation at a holding pressure at which flow limitation occurred and at 5 cm H2O below the holding pressure in children with OSAS and in control subjects. Setting: Sleep laboratory. Participants: Fourteen children with OSAS and 23 normal control subjects. Results: In both sleep states, control subjects were able to maintain airflow, whereas subjects with OSAS preserved airflow in SWS but had a significant decrease in airflow during REM sleep (change in airflow of 18.58 ± 12.41 mL/s for control subjects vs −44.33 ± 14.09 mL/s for children with OSAS, P = 0.002). Although tidal volume decreased, patients with OSAS were able to maintain minute ventilation by increasing the respiratory rate and also had an increase in inspiratory time and inspiratory time per total respiratory cycle time Conclusion: Children with OSAS do not maintain airflow in the face of upper-airway inspiratory-pressure drops during REM sleep, indicating a more collapsible upper airway, compared with that of control subjects during REM sleep. However, compensatory mechanisms exist to maintain minute ventilation. Local reflexes, central control mechanisms, or both reflexes and control mechanisms need to be further explored to better understand the pathophysiology of this abnormality and the compensation mechanism. Citation: Huang J; Karamessinis LR; Pepe ME; Glinka SM; Samuel JM; Gallagher PR; Marcus CL. Upper airway collapsibility during REM sleep in children with the obstructive sleep apnea syndrome. SLEEP 2009;32(9):1173-1181. PMID:19750922

Influence of Gender and Age on Upper-Airway Length During Development

PubMed Central

Ronen, Ohad; Malhotra, Atul; Pillar, Giora

2008-01-01

OBJECTIVE Obstructive sleep apnea has a strong male predominance in adults but not in children. The collapsible portion of the upper airway is longer in adult men than in women (a property that may increase vulnerability to collapse during sleep). We sought to test the hypothesis that in prepubertal children, pharyngeal airway length is equal between genders, but after puberty boys have a longer upper airway than girls, thus potentially contributing to this change in apnea propensity. METHODS Sixty-nine healthy boys and girls who had undergone computed tomography scans of their neck for other reasons were selected from the computed tomography archives of Rambam and Carmel hospitals. The airway length was measured in the midsagittal plane and defined as the length between the lower part of the posterior hard palate and the upper limit of the hyoid bone. Airway length and normalized airway length/body height were compared between the genders in prepubertal (4- to 10-year-old) and postpubertal (14- to 19-year-old) children. RESULTS In prepubertal children, airway length was similar between boys and girls (43.2 ± 5.9 vs 46.8 ± 7.7 mm, respectively). When normalized to body height, airway length/body height was significantly shorter in prepubertal boys than in girls (0.35 ± 0.03 vs 0.38 ± 0.04 mm/cm). In contrast, postpubertal boys had longer upper airways (66.5 ± 9.2 vs 52.2 ± 7.0 mm) and normalized airway length/body height (0.38 ± 0.05 vs 0.33 ± 0.05 mm/cm) than girls. CONCLUSIONS Although boys have equal or shorter airway length compared with girls among prepubertal children, after puberty, airway length and airway length normalized for body height are significantly greater in boys than in girls. These data suggest that important anatomic changes at puberty occur in a gender-specific manner, which may be important in explaining the male predisposition to pharyngeal collapse in adults. PMID:17908723

Collapse Pits

NASA Technical Reports Server (NTRS)

2005-01-01

24 April 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a large and several small pits formed by collapse along the trend of a fault system in the Uranius Fossae region of Mars. Running diagonal from middle-right toward lower left is a trough that intersects the pit. The trough is a typical graben formed by faulting as the upper crust of Mars split and pulled apart at this location. The opening of the graben also led to formation of the collapse pits.

Location near: 26.2oN, 88.7oW Image width: 3 km (1.9 mi) Illumination from: lower left Season: Northern Summer

Extensively Drug-Resistant Tuberculosis (XDR-TB) - A Potential Threat in Ireland

PubMed Central

Mc Laughlin, Anne Marie; O’Donnell, Rory A; Gibbons, Noel; Scully, Mary; O’Flangan, Darina; Keane, Joseph

2007-01-01

We describe a case of a 25 year old female from Lithuania who presented with a productive cough. Chest radiograph demonstrated an infiltrate in the left upper lobe and a cavitating lesion in the right middle lobe. Sensitivity testing of her sputum led to a diagnosis of extensively drug-resistant tuberculosis (XDR-TB). This is the first case in Ireland and highlights the need for physicians to be aware of the possibility of XDR-TB. Moreover it underlines the need for improvement in service provision in terms of a TB reference laboratory and TB clinics. PMID:19340317

Controlling factors of turf-banked solifluction lobe evolution in the Turtmann glacier forefield (Switzerland)

NASA Astrophysics Data System (ADS)

Draebing, Daniel; Eichel, Jana

2016-04-01

Soil structure and moisture, thermal conditions and vegetation control solifluction movement, however, the spatial distribution of controlling factors and resultant spatial variability of movement are poorly understood. We use a (1) geomorphological and vegetation mapping of solifluction lobe properties, (2) temperature loggers to quantify thermal conditions, (3) 2D Electrical Resistivity Tomography (ERT), Puerkhauer drilling and TDR measurements to evaluate material properties as well as (4) 3D Time-Lapse ERT to quantify spatial variability of material properties. Our results are used to (5) evaluate the influence of potential controlling factors on solifluction movement. Investigations took place on three turf-banked lobes (TBL) located at proximal and distal slopes of Little Ice Age and 1920s lateral moraines in the Turtmann glacier forefield, Swiss Alps. (1) Vegetation is spatially differentiated at TBLs. The treads are mostly covered by the ecosystem engineer Dryas octopetala, while other dwarf shrubs, shrubs and pioneer species were found at the high lobe risers (0.8-1.8 m). In contrast, less vegetated ridge-like features at the upper part of the treads are colonized by frost-tolerant species. Large blocks are located at the lobe fronts, probably impeding the lobe movement. (2) Temperature loggers show a lack of ground cooling due to snow isolation at the vegetated lower tread between 2014 and 2015. Thus, significant ground cooling in winter is reduced to the wind-exposed upper parts (ridges). (3) TBL material consists of sandy silt, thus, lobe material is much finer than subjacent moraine till and indicates former colluviation. As a consequence, 2D ERT demonstrates low-resistant areas until depths equal to riser height, thus, the finer TBL body is higher saturated than the coarser surrounding parent slope and more susceptible to gelifluction. On the contrary, risers show high resistivities indicating dry conditions which are supported by TDR results. Furthermore, ERT demonstrates the absence of permafrost in all measured TBLs. (4) Time-Lapse 3D ERT shows low-resistant areas at the rim of lobes in contrast to the high-resistant treads. In addition, resistivity increases with TBL depth. Thus, resistivity values indicate higher saturated conditions along the lobe axis with decreasing saturated conditions at the rim. (5) High-saturated conditions favour gelifluction movement while low-freezing activity and dense vegetation cover result in a lack of ice lenses and absence of permafrost and, thus, impermeable layers. Therefore, the highly permeable material favours drainage and seepage without development of critical pore water pressures. The D. octopetala mat on the tread increases near-surface shear strength, which decreases near-surface movement. In addition, later successional shrubs species colonizing the risers indicate limited frontal movement. As a consequence, our results suggest that solifluction movement is limited to the low- vegetation cover, highly saturated parts of the lobe affected by winter ground cooling. However, the large riser height reflects high past solifluction activity. Location of the lobes at the foot of slopes and large riser height indicate that TBLs are close to their final cycle of development. Due to the moraine age, the length of the cycle can be assumed to be maximum 100 years.

Trazodone Increases the Respiratory Arousal Threshold in Patients with Obstructive Sleep Apnea and a Low Arousal Threshold

PubMed Central

Eckert, Danny J.; Malhotra, Atul; Wellman, Andrew; White, David P.

2014-01-01

Study Objectives: The effect of common sedatives on upper airway physiology and breathing during sleep in obstructive sleep apnea (OSA) has been minimally studied. Conceptually, certain sedatives may worsen OSA in some patients. However, sleep and breathing could improve with certain sedatives in patients with OSA with a low respiratory arousal threshold. This study aimed to test the hypothesis that trazodone increases the respiratory arousal threshold in patients with OSA and a low arousal threshold. Secondary aims were to examine the effects of trazodone on upper airway dilator muscle activity, upper airway collapsibility, and breathing during sleep. Design: Patients were studied on 4 separate nights according to a within-subjects cross-over design. Setting: Sleep physiology laboratory. Patients: Seven patients with OSA and a low respiratory arousal threshold. Interventions: In-laboratory polysomnograms were obtained at baseline and after 100 mg of trazodone was administered, followed by detailed overnight physiology experiments under the same conditions. During physiology studies, continuous positive airway pressure was transiently lowered to measure arousal threshold (negative epiglottic pressure prior to arousal), dilator muscle activity (genioglossus and tensor palatini), and upper airway collapsibility (Pcrit). Measurements and Results: Trazodone increased the respiratory arousal threshold by 32 ± 6% (-11.5 ± 1.4 versus -15.3 ± 2.2 cmH2O, P < 0.01) but did not alter the apnea-hypopnea index (39 ± 12 versus 39 ± 11 events/h sleep, P = 0.94). Dilator muscle activity and Pcrit also did not systematically change with trazodone. Conclusions: Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold without major impairment in dilator muscle activity or upper airway collapsibility. However, the magnitude of change in arousal threshold was insufficient to overcome the compromised upper airway anatomy in these patients. Citation: Eckert DJ; Malhotra A; Wellman A; White DP. Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold. SLEEP 2014;37(4):811-819. PMID:24899767

Influence of filling-drawdown cycles of the Three Gorges reservoir on deformation and failure behaviors of anaclinal rock slopes in the Wu Gorge

NASA Astrophysics Data System (ADS)

Huang, Da; Gu, Dong Ming

2017-10-01

The upper Wu Gorge on the Yangtze River has been the site of tens of reservoir-induced landslides since the filling of the Three Gorges reservoir in 2003. These landslides have been occurring in heavily fractured carbonate rock materials along the rim of the reservoir in the Wu Gorge. A detailed investigation was carried out to examine the influence of reservoir operations (filling and drawdown) on slope stabilities in the upper Wu Gorge. Field investigations reveal many collapses of various types occurred at the toe of the anaclinal rock slopes, owing to the long-term intensive river erosion caused by periodic fluctuation of the reservoir level. Analysis of data from deformation monitoring suggests that the temporal movement of the slopes shows seasonal fluctuations that correlate with reservoir levels and drawdown conditions, with induced slope acceleration peaking when reservoir levels are lowest. This may illustrate that the main mechanism is the reservoir drawdown, which induces an episodic seepage force in the highly permeable materials at the slope toes, and thus leads to the episodic rockslides. The coupled hydraulic-mechanical (HM) modeling of the G2 landslide, which occurred in 2008, shows that collapse initiated at the submerged slope toe, which then caused the upper slope to collapse in a rock topple-rock slide pattern. The results imply that preventing water erosion at the slope toe might be an effective way for landslide prevention in the study area.

Morphologic Response of the Pulmonary Vasculature to Endoscopic Lung Volume Reduction.

PubMed

Rahaghi, Farbod N; Come, Carolyn E; Ross, James; Harmouche, Rola; Diaz, Alejandro A; Estepar, Raul San Jose; Washko, George

Endoscopic Lung Volume Reduction has been used to reduce lung hyperinflation in selected patients with severe emphysema. Little is known about the effect of this procedure on the intraparenchymal pulmonary vasculature. In this study we used CT based vascular reconstruction to quantify the effect of the procedure on the pulmonary vasculature. Intraparenchymal vasculature was reconstructed and quantified in 12 patients with CT scans at baseline and 12 weeks following bilateral introduction of sealants in the upper lobes. The volume of each lung and each lobe was measured, and the vascular volume profile was calculated for both lower lobes. The detected vasculature was further labeled manually as arterial or venous in the right lower lobe. There was an increase in the volume of the lower lobes (3.14L to 3.25L, p=0.0005). There was an increase in BV5, defined as the volume of blood vessels with cross sectional area of less than 5mm 2 , (53.2ml to 57.9ml, p=0.03). This was found to be correlated with the increase in lower lobe volumes (R=0.65, p=0.02). The changes appear to be symmetric for veins and arteries with a correlation coefficient of 0.87 and a slope of near identity. In the subjects studied, there was an increase, from baseline, in BV5 in the lower lobes that correlated with the change in the volume of the lower lobes. The change appeared to be symmetric for both arteries and veins. The study illustrates the use of intraparenchymal pulmonary vascular reconstruction to study morphologic changes in response to interventions.

Microsurgical anatomy of the central lobe.

PubMed

Frigeri, Thomas; Paglioli, Eliseu; de Oliveira, Evandro; Rhoton, Albert L

2015-03-01

The central lobe consists of the pre- and postcentral gyri on the lateral surface and the paracentral lobule on the medial surface and corresponds to the sensorimotor cortex. The objective of the present study was to define the neural features, craniometric relationships, arterial supply, and venous drainage of the central lobe. Cadaveric hemispheres dissected using microsurgical techniques provided the material for this study. The coronal suture is closer to the precentral gyrus and central sulcus at its lower rather than at its upper end, but they are closest at a point near where the superior temporal line crosses the coronal suture. The arterial supply of the lower two-thirds of the lateral surface of the central lobe was from the central, precentral, and anterior parietal branches that arose predominantly from the superior trunk of the middle cerebral artery. The medial surface and the superior third of the lateral surface were supplied by the posterior interior frontal, paracentral, and superior parietal branches of the pericallosal and callosomarginal arteries. The venous drainage of the superior two-thirds of the lateral surface and the central lobe on the medial surface was predominantly through the superior sagittal sinus, and the inferior third of the lateral surface was predominantly through the superficial sylvian veins to the sphenoparietal sinus or the vein of Labbé to the transverse sinus. The pre- and postcentral gyri and paracentral lobule have a morphological and functional anatomy that differentiates them from the remainder of their respective lobes and are considered by many as a single lobe. An understanding of the anatomical relationships of the central lobe can be useful in preoperative planning and in establishing reliable intraoperative landmarks.

Study of the upper airway of obstructive sleep apnea patient using fluid structure interaction.

PubMed

Liu, Yang; Mitchell, Jennifer; Chen, Yitung; Yim, Woosoon; Chu, Wenxiao; Wang, Robert C

2018-02-01

Up to 14% of the U.S. population is estimated to have obstructive sleep apnea (OSA), while the outcomes of the treatments have variable results. In the current study, a three-dimensional fluid-structure interaction modeling was applied to simulate the upper airway to identify the precise location, severity, and characteristic of airway collapse. This was accomplished using Simpleware ® and ANSYS ® software applied to a 3-D rendering of the airway in a real patient with severe OSA. During this simulation, areas which are prone to collapse and precipitate apneic episodes were identified at the tip of the soft palate and the base of the tongue, with intrathoracic pressure as low as -1370 Pa. These results are consistent with anatomical structures currently indicated and targeted in the treatment of OSA. This improved FSI modeling simulation, which is the first to completely model the whole upper airway without consideration of the nasal cavity in OSA, and can allow virtual modification of the airway prior to actual treatment by doctors. Copyright © 2018 Elsevier B.V. All rights reserved.

RESPIRATORY MODULATION OF LINGUAL MUSCLE ACTIVITY ACROSS SLEEP-WAKE STATES IN RATS

PubMed Central

Stettner, Georg M.; Rukhadze, Irma; Mann, Graziella L.; Lei, Yanlin; Kubin, Leszek

2013-01-01

In obstructive sleep apnea (OSA) patients, inspiratory activation (IA) of lingual muscles protects the upper airway from collapse. We aimed to determine when rats’ lingual muscles exhibit IA. In 5 Sprague-Dawley and 3 Wistar rats, we monitored cortical EEG and lingual, diaphragmatic and nuchal electromyograms (EMGs), and identified segments of records when lingual EMG exhibited IA. Individual segments lasted 2.4–269 s (median: 14.5 s), most (89%) occurred during slow-wave sleep (SWS), and they collectively occupied 0.3–6.1% of the total recording time. IA usually started to increase with a delay after SWS onset and ended with an arousal, or declined prior to rapid eye movement sleep. IA of lingual EMG was not accompanied by increased diaphragmatic activity or respiratory rate changes, but occurred when cortical EEG power was particularly low in a low beta-1 frequency range (12.5–16.4 Hz). A deep SWS-related activation of upper airway muscles may be an endogenous phenomenon designed to protect the upper airway against collapse. PMID:23732510

Clinical and Genetic Implications of Mutation Burden in Squamous Cell Carcinoma of the Lung.

PubMed

Okamoto, Tatsuro; Takada, Kazuki; Sato, Seijiro; Toyokawa, Gouji; Tagawa, Tetsuzo; Shoji, Fumihiro; Nakanishi, Ryota; Oki, Eiji; Koike, Terumoto; Nagahashi, Masayuki; Ichikawa, Hiroshi; Shimada, Yoshifumi; Watanabe, Satoshi; Kikuchi, Toshiaki; Akazawa, Kouhei; Lyle, Stephen; Takabe, Kazuaki; Okuda, Shujiro; Sugio, Kenji; Wakai, Toshifumi; Tsuchida, Masanori; Maehara, Yoshihiko

2018-06-01

Lung squamous cell carcinoma (LSCC) is a major histological subtype of lung cancer. In this study, we investigated genomic alterations in LSCC and evaluated the clinical implications of mutation burden (MB) in LSCC. Genomic alterations were determined in Japanese patients with LSCC (N = 67) using next-generation sequencing of 415 known cancer genes. MB was defined as the number of non-synonymous mutations per 1 Mbp. Programmed death-ligand 1 (PD-L1) protein expression in cancer cells was evaluated by immunohistochemical analysis. TP53 gene mutations were the most common alteration (n = 51/67, 76.1%), followed by gene alterations in cyclin-dependent kinase inhibitor 2B (CDKN2B; 35.8%), CDKN2A (31.3%), phosphatase and tensin homolog (30.0%), and sex-determining region Y-box 2 (SOX2, 28.3%). Histological differentiation was significantly poorer in tumors with high MB (greater than or equal to the median MB) compared with that in tumors with low MB (less than the median MB; p = 0.0446). The high MB group had more tumors located in the upper or middle lobe than tumors located in the lower lobe (p = 0.0019). Moreover, cancers in the upper or middle lobes had significantly higher MB than cancers in the lower lobes (p = 0.0005), and tended to show higher PD-L1 protein expression (p = 0.0573). SOX2 and tyrosine kinase non-receptor 2 amplifications were associated with high MB (p = 0.0065 and p = 0.0010, respectively). The MB level differed according to the tumor location in LSCC, suggesting that the location of cancer development may influence the genomic background of the tumor.

Depositional environments and controls of Juncal Formation, southern San Rafael Mountains, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, T.J.

1987-05-01

The lower to middle Eocene Juncal Formation, north of the Santa Ynez fault in easternmost Santa Barbara County, represents the onset of marine sedimentation following an approximately 20-m.y. hiatus. The Juncal paraconformably overlies the upper Campanian Unnamed sandstone and is gradationally overlain by the middle Eocene Matilija Formation. Access to the Juncal exposures of this area was considerably enhanced by the Wheeler fire of July 1985. Facies analysis of both the vertical and lateral exposures of the Juncal Formation (approx. 1400 m thick) indicate that the Juncal represents coalescing outer-fan depositional lobes. This interpretation is based on the lateral continuitymore » of sandstone beds, presence of thickening-upward cycles, and high-concentration sediment gravity flows, bathyal fauna, and regional associations. Local channelization (to 10 m deep) represents the extension of a mid-fan channel over its associated depositional lobe. Outcrops are subparallel to depositional strike in the eastern part of the study area and form a broad syncline in the western part. Together, these exposures allow documentation of the depositional lobes vertically, laterally, and longitudinally. Outer-fan deposits of the Juncal Formation are part of a progradational basin-filling episode. The Juncal grades upward into the outer- to mid-fan depositions of the lower Matilija Formation. The upper Matilija Formation shoals upward into deltaic facies. This regressive sedimentary sequence was probably initiated by the major sea level fall which occurred near the early/middle Eocene boundary and coincides with the onset of fan sedimentation elsewhere along the California margin. Within the study area, depositional lobe activity was probably governed by either minor fluctuations in relative sea level or channel switching up-system.« less

Test-retest reliability of diffusion tensor imaging of the liver at 3.0 T.

PubMed

Girometti, Rossano; Maieron, Marta; Lissandrello, Giovanni; Bazzocchi, Massimo; Zuiani, Chiara

2015-06-01

This study was done to evaluate test-retest reliability of liver diffusion tensor imaging (LDTI). Ten healthy volunteers (median age 23 years) underwent two LDTI scans on a 3.0 T magnet during two imaging sessions separated by 2 weeks (session-1/-2, respectively). Fifteen gradient directions and b values of 0-1,000 s/mm(2) were used. Two radiologists in consensus assessed liver apparent diffusion coefficient (ADC) and fraction of anisotropy (FA) values on ADC and FA maps at four reference levels, namely: right upper level (RUL), right lower level (RLL), left upper level (LUL) and left lower level (LLL). We then assessed (a) whether ADC and FA values overlapped when measured on different levels within the same imaging session or between different imaging sessions; (b) the degree of variability on an intra-session and inter-session basis, respectively, using the coefficient of variation (CV). In sessions 1 and 2, the ADC/FA values were significantly larger in the left liver lobe (LUL/LLL) compared to right liver lobe (RUL/RLL) (p < 0.05/6). Intra-session CVs were 9.51 % (session 1) and 9.73 % (session 2) for ADC, and 12.93 % (session 1) and 11.82 % (session 2) for FA, respectively. When comparing RUL, RLL, LUL and LLL on an inter-session basis, CVs were 6.52, 8.20, 6.52 and 11.06 % for ADC, and 15.42, 15.80, 15.42 and 6.80 % for FA, respectively. LDTI provides consistent and repeatable measurements. However, since larger left lobe ADC/FA values can be attributed to artefacts, right lobe values should be considered the most reliable measurements of water diffusivity within the liver.

Evaluation of normal lung tissue complication probability in gated and conventional radiotherapy using the 4D XCAT digital phantom.

PubMed

Shahzadeh, Sara; Gholami, Somayeh; Aghamiri, Seyed Mahmood Reza; Mahani, Hojjat; Nabavi, Mansoure; Kalantari, Faraz

2018-06-01

The present study was conducted to investigate normal lung tissue complication probability in gated and conventional radiotherapy (RT) as a function of diaphragm motion, lesion size, and its location using 4D-XCAT digital phantom in a simulation study. Different time series of 3D-CT images were generated using the 4D-XCAT digital phantom. The binary data obtained from this phantom were then converted to the digital imaging and communication in medicine (DICOM) format using an in-house MATLAB-based program to be compatible with our treatment planning system (TPS). The 3D-TPS with superposition computational algorithm was used to generate conventional and gated plans. Treatment plans were generated for 36 different XCAT phantom configurations. These included four diaphragm motions of 20, 25, 30 and 35 mm, three lesion sizes of 3, 4, and 5 cm in diameter and each tumor was placed in four different lung locations (right lower lobe, right upper lobe, left lower lobe and left upper lobe). The complication of normal lung tissue was assessed in terms of mean lung dose (MLD), the lung volume receiving ≥20 Gy (V20), and normal tissue complication probability (NTCP). The results showed that the gated RT yields superior outcomes in terms of normal tissue complication compared to the conventional RT. For all cases, the gated radiation therapy technique reduced the mean dose, V20, and NTCP of lung tissue by up to 5.53 Gy, 13.38%, and 23.89%, respectively. The results of this study showed that the gated RT provides significant advantages in terms of the normal lung tissue complication, compared to the conventional RT, especially for the lesions near the diaphragm. Copyright © 2018 Elsevier Ltd. All rights reserved.

Severe pulmonary hypertension due to combined pulmonary fibrosis and emphysema: another cause of death among smokers

PubMed Central

Hirano, André Carramenha de Góes; Targueta, Eduardo Pelegrineti; Martines, João Augusto dos Santos; Andrade, Dafne; Lovisolo, Silvana Maria; Felipe-Silva, Aloisio

2017-01-01

In 2005, the combined pulmonary fibrosis and emphysema (CPFE) was first defined as a distinct entity, which comprised centrilobular or paraseptal emphysema in the upper pulmonary lobes, and fibrosis in the lower lobes accompanied by reduced diffused capacity of the lungs for carbon monoxide (DLCO). Recently, the fibrosis associated with the connective tissue disease was also included in the diagnosis of CPFE, although the exposure to tobacco, coal, welding, agrochemical compounds, and tire manufacturing are the most frequent causative agents. This entity characteristically presents reduced DLCO with preserved lung volumes and severe pulmonary hypertension, which is not observed in emphysema and fibrosis alone. We present the case of a 63-year-old woman with a history of heavy tobacco smoking abuse, who developed progressive dyspnea, severe pulmonary hypertension, and cor pulmonale over a 2-year period. She attended the emergency facility several times complaining of worsening dyspnea that was treated as decompensate chronic obstructive pulmonary disease (COPD). The imaging examination showed paraseptal emphysema in the upper pulmonary lobes and fibrosis in the middle and lower lobes. The echo Doppler cardiogram revealed the dilation of the right cardiac chambers and pulmonary hypertension, which was confirmed by pulmonary trunk artery pressure measurement by catheterization. During this period, she was progressively restricted to the minimal activities of daily life and dependent on caregivers. She was brought to the hospital neurologically obtunded, presenting anasarca, and respiratory failure, which led her to death. The autopsy showed signs of pulmonary hypertension and findings of fibrosis and emphysema in the histological examination of the lungs. The authors highlight the importance of the recognition of this entity in case of COPD associated with severe pulmonary hypertension of unknown cause. PMID:28740835

Non-intubated uniportal left-lower lobe upper segmentectomy (S6)

PubMed Central

Navarro-Martinez, Jose; Bolufer, Sergio; Sesma, Julio; Lirio, Francisco; Galiana, Maria; Rivera, Maria Jesus

2017-01-01

Worldwide accepted indications of anatomical segmentectomies are mainly early stage primary adenocarcinomas, pulmonary metastasis and benign conditions. Their performance through uniportal VATS has become more and more popular due to the less invasiveness of the whole procedure under this approach. Recently, many efforts have focused on non-intubated spontaneously breathing management of lobectomies and anatomical segmentectomies, although specific selection criteria and main advantages are not completely standardized. In a 62-year-old thin man with two pulmonary residual metastasis from sigma adenocarcinoma, after chemotherapy plus antiangiogenic treatment, we indicated a single-incision video-assisted left-lower lobe (LLL) upper segmentectomy (S6) under spontaneous breathing and intercostal blockade. Total operation time was 240 minutes. Chest tube was removed at 24 hours and the patient was discharge on postoperative day 2 without any complication. Non-intubated uniportal VATS is a safe and reasonable approach for lung-sparing resections in selected patients, although more evidence is required for selecting which patients can benefit more over standard intubated procedures. PMID:29078611

Non-intubated uniportal left-lower lobe upper segmentectomy (S6).

PubMed

Galvez, Carlos; Navarro-Martinez, Jose; Bolufer, Sergio; Sesma, Julio; Lirio, Francisco; Galiana, Maria; Rivera, Maria Jesus

2017-01-01

Worldwide accepted indications of anatomical segmentectomies are mainly early stage primary adenocarcinomas, pulmonary metastasis and benign conditions. Their performance through uniportal VATS has become more and more popular due to the less invasiveness of the whole procedure under this approach. Recently, many efforts have focused on non-intubated spontaneously breathing management of lobectomies and anatomical segmentectomies, although specific selection criteria and main advantages are not completely standardized. In a 62-year-old thin man with two pulmonary residual metastasis from sigma adenocarcinoma, after chemotherapy plus antiangiogenic treatment, we indicated a single-incision video-assisted left-lower lobe (LLL) upper segmentectomy (S6) under spontaneous breathing and intercostal blockade. Total operation time was 240 minutes. Chest tube was removed at 24 hours and the patient was discharge on postoperative day 2 without any complication. Non-intubated uniportal VATS is a safe and reasonable approach for lung-sparing resections in selected patients, although more evidence is required for selecting which patients can benefit more over standard intubated procedures.

Anatomic optical coherence tomography for dynamic imaging of the upper airway

NASA Astrophysics Data System (ADS)

Bu, Ruofei; Balakrishnan, Santosh; Iftimia, Nicusor; Price, Hillel; Zdanski, Carlton; Oldenburg, Amy L.

2017-03-01

To aid in diagnosis and treatment of upper airway obstructive disorders (UAOD), we propose anatomic Optical Coherence Tomography (aOCT) for endoscopic imaging of the upper airway lumen with high speed and resolution. aOCT and CT scans are performed sequentially on in vivo swine to compare dynamic airway imaging data. The aOCT system is capable of capturing the dynamic deformation of the airway during respiration. This may lead to methods for airway elastography and aid in our understanding of dynamic collapse in UAOD.

Collisionless slow shocks in magnetotail reconnection

NASA Astrophysics Data System (ADS)

Cremer, Michael; Scholer, Manfred

The kinetic structure of collisionless slow shocks in the magnetotail is studied by solving the Riemann problem of the collapse of a current sheet with a normal magnetic field component using 2-D hybrid simulations. The collapse results in a current layer with a hot isotropic distribution and backstreaming ions in a boundary layer. The lobe plasma outside and within the boundary layer exhibits a large perpendicular to parallel temperature anisotropy. Waves in both regions propagate parallel to the magnetic field. In a second experiment a spatially limited high density beam is injected into a low beta background plasma and the subsequent wave excitation is studied. A model for slow shocks bounding the reconnection layer in the magnetotail is proposed where backstreaming ions first excite obliquely propagating waves by the electromagnetic ion/ion cyclotron instability, which lead to perpendicular heating. The T⊥/T∥ temperature anisotropy subsequently excites parallel propagating Alfvén ion cyclotron waves, which are convected into the slow shock and are refracted in the downstream region.

A functional near-infrared spectroscopy study of lexical decision task supports the dual route model and the phonological deficit theory of dyslexia.

PubMed

Sela, Itamar; Izzetoglu, Meltem; Izzetoglu, Kurtulus; Onaral, Banu

2014-01-01

The dual route model (DRM) of reading suggests two routes of reading development: the phonological and the orthographic routes. It was proposed that although the two routes are active in the process of reading; the first is more involved at the initial stages of reading acquisition, whereas the latter needs more reading training to mature. A number of studies have shown that deficient phonological processing is a core deficit in developmental dyslexia. According to the DRM, when the Lexical Decision Task (LDT) is performed, the orthographic route should also be involved when decoding words, whereas it is clear that when decoding pseudowords the phonological route should be activated. Previous functional near-infrared spectroscopy (fNIR) studies have suggested that the upper left frontal lobe is involved in decision making in the LDT. The current study used fNIR to compare left frontal lobe activity during LDT performance among three reading-level groups: 12-year-old children, young adult dyslexic readers, and young adult typical readers. Compared to typical readers, the children demonstrated lower activity under the word condition only, whereas the dyslexic readers showed lower activity under the pseudoword condition only. The results provide evidence for upper left frontal lobe involvement in LDT and support the DRM and the phonological deficit theory of dyslexia.

Comparison of drug-induced sleep endoscopy and Müller's maneuver in diagnosing obstructive sleep apnea using the VOTE classification system.

PubMed

Yegïn, Yakup; Çelik, Mustafa; Kaya, Kamïl Hakan; Koç, Arzu Karaman; Kayhan, Fatma Tülin

Knowledge of the site of obstruction and the pattern of airway collapse is essential for determining correct surgical and medical management of patients with Obstructive Sleep Apnea Syndrome (OSAS). To this end, several diagnostic tests and procedures have been developed. To determine whether drug-induced sleep endoscopy (DISE) or Müller's maneuver (MM) would be more successful at identifying the site of obstruction and the pattern of upper airway collapse in patients with OSAS. The study included 63 patients (52 male and 11 female) who were diagnosed with OSAS at our clinic. Ages ranged from 30 to 66 years old and the average age was 48.5 years. All patients underwent DISE and MM and the results of these examinations were characterized according to the region/degree of obstruction as well as the VOTE classification. The results of each test were analyzed per upper airway level and compared using statistical analysis (Cohen's kappa statistic test). There was statistically significant concordance between the results from DISE and MM for procedures involving the anteroposterior (73%), lateral (92.1%), and concentric (74.6%) configuration of the velum. Results from the lateral part of the oropharynx were also in concordance between the tests (58.7%). Results from the lateral configuration of the epiglottis were in concordance between the tests (87.3%). There was no statistically significant concordance between the two examinations for procedures involving the anteroposterior of the tongue (23.8%) and epiglottis (42.9%). We suggest that DISE has several advantages including safety, ease of use, and reliability, which outweigh MM in terms of the ability to diagnose sites of obstruction and the pattern of upper airway collapse. Also, MM can provide some knowledge of the pattern of pharyngeal collapse. Furthermore, we also recommend using the VOTE classification in combination with DISE. Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

Calbindin D-28k and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis.

PubMed Central

Ferrer, I; Tuñón, T; Serrano, M T; Casas, R; Alcántara, S; Zújar, M J; Rivera, R M

1993-01-01

The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia. Images PMID:8459241

The Rise and Fall of the Soufriere Hills Volcano Lava Dome, Montserrat, BWI, July 2001-July 2003: Science, Hazards, and Volatile Public Perceptions

NASA Astrophysics Data System (ADS)

Dunkley, P.; Voight, B.; Edmonds, M.; Herd, R.; Strutt, M.; Thompson, G.; Bass, V.; Aspinall, W. P.; Neuberg, J.; Sparks, R.; Mattioli, G.; Hidayat, D.; Elsworth, D.; Widiwijayanti, C.

2003-12-01

Days after the major collapse (45 x 106 m3) of the eastern flank of the lava dome on 29 July 2001, new dome growth was observed within the 200-m deep collapse amphitheatre. accompanied by cyclic seismicity. By January 2002 the summit was broad with an altitude of 990m. A switch in dome activity occurred in April, but Growth nearly stagnated in June and part of July, with the top of the extrusion lobe at 1048m. but GPS monitoring suggested that the magma reservoir continued to inflate, and growth resumed in late July. In August, a lobe grew toward the north and buried the northern buttress and an important drainage channel that formerly led to the east. One of the regular six-monthly meetings of the Risk Assessment Panel (RAP) took place on 3-4 Sept 02 and concluded that if a NW switch in dome growth were to occur, the margins of the Belham Valley on the west could be at high risk; a flow and surge hazard line was provided to officials, crossing the populated area near Salem. Shortly after the RAP Report was finalized, a switch in growth direction toward the northwest in fact occurred. On 7 Oct, the RAP were asked to re-appraise Belham Valley risks given the altered but not unanticipated circumstances; they judged that a potential existed for a hazardous flow down Belham Valley, although RAP emphasized that their assessment did not predict that a large flow would occur soon, nor in that sector. On 8 Oct the Governor ordered an evacuation of an exclusion zone defined by the RAP's hazard line as adjusted to permit administrative control, and the boundary remained in force until Aug 03, with growing public discontent toward the Governor's exercise of Emergency Powers, and toward MVO, as expressed by a caustic vocal minority with provocative exacerbation by the local newspaper and some politicians. Meanwhile, dome growth continued with some switches in direction, a collapse of 5 x 106 m3 occurred eastward on 8 Dec to Spanish Point, and pyroclastic flows occurred in several drainages, mostly in Tar River to Tuitts Ghaut on the east, but also to Tyers Ghaut on the west, a tributary to Belham Valley. By late March the general summit area was at 1090m. In early June activity declined, but a hybrid earthquake swarm began on 9 July at a time of low SO2 emission and intensified generally in size and frequency to the morning of 12 July, when dome/talus collapses leading to pyroclastic flow activity began, building up during the day and peaking with larger flows in the evening. Mechanisms inducing collapse include a new pressurized growth pulse heralded by the hybrid events, and heavy morning rains. When the retrogressing collapse slices exposed conduit magma, explosions occurred, with the strongest (before midnight) causing a strong acoustic signal and an ash column to about 50,000 ft (VAAC). Heavy ash and lapilli fall (thickness to 15 cm) from these events affected all inhabited areas, and a hot pyroclastic surge destroyed monitoring equipment and killed many animals between Spanish Point and Tar River. The collapse volume greatly exceeded that of 2001, and the events were detected on MVO and CALIPSO monitoring systems, including three strainmeters. The exclusion zone restriction was lifted on 1 Aug 03.

Late Cenozoic regional collapse due to evaporite flow and Dissolution in the Carbondale Collapse Center, West-Central Colorado

USGS Publications Warehouse

Kirkham, R.M.; Streufert, R.K.; Budahn, J.R.; Kunk, Michael J.; Perry, W.J.

2001-01-01

Dissolution and flow of Pennsylvanian evaporitic rocks in west-central Colorado created the Carbondale Collapse Center, a 450 mi2 structural depression with about 4,000 ft of vertical collapse during the late Cenozoic. This paper describes evidence of collapse in the lower Roaring Fork River valley. Both the lateral extent and amount of vertical collapse is constrained by deformed upper Cenozoic volcanic rocks that have been correlated using field mapping, 40Ar/39Ar geochronology, geochemistry, and paleomagnetism. The Carbondale Collapse Center is one of at least two contiguous areas that have experienced major evaporite tectonism during the late Cenozoic. Historic sinkholes, deformed Holocene deposits, and modern high-salinity loads in the rivers and thermal springs indicate the collapse process continues today. Flow of evaporitic rocks is an important element in the collapse process, and during initial stages of collapse it was probably the primary causative mechanism. Dissolution, however, is the ultimate means by which evaporite is removed from the collapse area. As the Roaring Fork River began to rapidly down-cut through a broad volcanic plateau during the late Miocene, the underlying evaporite beds were subjected to differential overburden pressures. The evaporitic rocks flowed from beneath the upland areas where overburden pressures remained high, toward the Roaring Fork River Valley where the pressures were much lower. Along the valley the evaporitic rocks rose upward, sometimes as diapirs, forming or enhancing a valley anticline in bedrock and locally upwarping Pleistocene terraces. Wherever the evaporites encountered relatively fresh ground water, they were dissolved, forming underground voids into which overlying bedrock and surficial deposits subsided. The saline ground water eventually discharged to streams and rivers through thermal springs and by seepage into alluvial aquifers.

Caldera formation at Volcán Colima, Mexico, by a large large holocene volcanic debris avalanche

NASA Astrophysics Data System (ADS)

Luhr, James F.; Prestegaard, Karen L.

1988-12-01

About 4,300 years ago, 10 km 3 of the upper cone of ancestral Volcán Colima collapsed to the southwest leaving a horseshoe-shaped caldera 4 km in diameter. The collapse produced a massive volcanic debris avalanche deposit covering over 1550 km 2 on the southern flanks of the volcano and extending at least 70 km from the former summit. The avalanche followed a steep topographic gradient unobstructed by barriers, resulting in an unusually high area/volume ratio for the Colima deposit. The apparent coefficient of friction (fall height/distance traveled) for the Colima avalanche is 0.06, a low value similar to those of other large-volume deposits. The debris avalanche deposit contains 40-75% angular volcanic clasts from the ancestral cone, a small proportion of vesicular blocks that may be juvenile, and in distal exposures, rare carbonate clasts plucked from the underlying surface by the moving avalanche. Clasts range in size to over 20 m in diameter and are brecciated to different degrees, pulverized, and surrounded by a rock-flour matrix. The upper surface of the deposit shows prominent hummocky topography with closed depressions and surface boulders. A thick, coarse-grained, compositionally zoned scoria-fall layer on the upper northeastern slope of the volcano may have erupted at the time of collapse. A fine-grained surge layer is present beneath the avalanche deposit at one locality, apparently representing an initial blast event. Most of the missing volume of the ancestral volcano has since been restored at an average rate of 0.002 km 3/yr through repeated eruptions from the post-caldera cone. As a result, the southern slope of Volcán Colima may again be susceptible to collapse. Over 200,000 people are now living on primary or secondary deposits of the debris avalanche, and a repetition of this event would constitute a volcanic disaster of great magnitude. Ancestral Volcán Colima grew on the southern, trenchward flank of the earlier and larger volcano Nevado de Colima. Trenchward collapse was favored by the buttressing effect of Nevado, the rapid elevation drop to the south, and the intrusion of magma into the southern flank of the ancestral volcano. Other such trenchward-younging, paired volcanoes are known from Mexico, Guatemala, El Salvador, Chile, and Japan. The trenchward slopes of the younger cones are common sites for cone collapse to form avalanche deposits, as occurred at Colima and Popocatepetl in Mexico and at San Pedro Volcano in Chile.

Combined Pulmonary Fibrosis and Emphysema Syndrome

PubMed Central

Rounds, Sharon I. S.

2012-01-01

There is increasing clinical, radiologic, and pathologic recognition of the coexistence of emphysema and pulmonary fibrosis in the same patient, resulting in a clinical syndrome known as combined pulmonary fibrosis and emphysema (CPFE) that is characterized by dyspnea, upper-lobe emphysema, lower-lobe fibrosis, and abnormalities of gas exchange. This syndrome frequently is complicated by pulmonary hypertension, acute lung injury, and lung cancer. The CPFE syndrome typically occurs in male smokers, and the mortality associated with this condition, especially if pulmonary hypertension is present, is significant. In this review, we explore the current state of the literature and discuss etiologic factors and clinical characteristics of the CPFE syndrome. PMID:22215830

Volcano Near Pavonis Mons

NASA Technical Reports Server (NTRS)

2003-01-01

MGS MOC Release No. MOC2-549, 19 November 2003

The volcanic plains to the east, southeast, and south of the giant Tharsis volcano, Pavonis Mons, are dotted by dozens of small volcanoes. This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows an example located near 2.1oS, 109.1oW. The elongate depression in the lower left (southwest) quarter of the image is the collapsed vent area for this small, unnamed volcano. A slightly sinuous, leveed channel runs from the depression toward the upper right (north-northeast); this is the trace of a collapsed lava tube. The entire scene has been mantled by dust, such that none of the original volcanic rocks are exposed--except minor occurrences on the steepest slopes in the vent area. The scene is 3 km (1.9 mi) wide and illuminated by sunlight from the left/upper left.

Primary intrapulmonary solitary fibrous tumours

PubMed Central

Lin, Xia; Xiang, Yingming; Shi, Hongcan; Zhang, Fangbiao

2018-01-01

Due to the extreme rarity of primary intrapulmonary solitary fibrous tumours (SFTs), their clinical course, imaging characteristics, diagnosis, treatment and prognosis are poorly understood. The present study therefore assessed the diagnosis and management of primary intrapulmonary SFTs and systematically reviewed previously reported cases in the literature. A total of 5 patients who underwent resection for primary intrapulmonary SFTs were enrolled in the present study and their clinical course, tumour characteristics, management and survival were assessed in this retrospective study. Relevant studies regarding primary intrapulmonary SFTs were searched using PubMed and tumour characteristics, clinicopathologic features, therapeutic strategy and survival outcomes were reviewed. Of the 5 cases, all were males, with a mean age of 57.6 years (range, 37–68 years). All patients were asymptomatic and were identified incidentally on routine computed tomography examination. A total of 3 patients underwent thoracotomy and 2 patients underwent video-assisted thoracoscopic surgery. All tumours were completely resected. Postoperative haemorrhage occurred in 1 patient and he received surgical intervention for haemostasis. The average hospital stay was 15 (4–22) days, and no mortality occurred. The mean length of the postoperative follow-up was 37.6 (1–67) months. One patient was lost to follow-up, and 4 patients were asymptomatic. A total of 19 studies were identified from database searches. They included a total of 45 patients: Twenty-three males and 22 females (mean age, 59.4 years; range, 7–81 years). A total of 12 patients were asymptomatic, and pain and coughing were the major symptoms. Five, one, two, four, and 17 tumours occurred in the right upper lobe, right middle lobe, right lower lobe, left upper lobe and left lower lobe, respectively. A total of 39 patients underwent surgery, 1 patient underwent radiotherapy, and 1 patient underwent radiofrequency ablation. A total of 22 patients were followed up and the mean length of the postoperative follow-up was 48 (1–168) months. One patient was diagnosed with chest wall metastases, and 5 patients succumbed to mortality. To conclude, primary intrapulmonary SFTs are extremely rare and typically identified incidentally. The present findings indicated that the left lower lobe was the most common site location and complete surgical resection is a safe and effective treatment. PMID:29467886

Malignant perivascular epithelioid cell neoplasm of the mediastinum and the lung: one case report.

PubMed

Liang, Wenjie; Xu, Shunliang; Chen, Feng

2015-06-01

A perivascular epithelioid cell neoplasm (PEComa) in the chest is rare, let alone in the mediastinum and lung. A 63-year-old man was admitted to our hospital with chest pain for more than 2 months and was found to have an opacity in his mediastinum and lung for 3 weeks. Enhanced chest computed tomography (CT) revealed a mass in both the left upper lobe and central anterior mediastinum. To identify the disease, a CT-guided percutaneous transthoracic needle biopsy of the upper left lung lesions was performed. The pathology result was consistent with epithelioid angiomyolipoma/PEComa. After a standard preparation for surgery, the neoplasms in the mediastinum and left lung were resected. The operative findings revealed extensive mediastinal tumor invasion in parts adjacent to the pericardium, including the mediastinal pleura, left pulmonary artery and vein, and phrenic nerve. The left lung tumor had invaded the lung membranes. The final pathologic diagnosis was malignant epithelioid angioleiomyoma in the left upper lung and mediastinum. Later, the mediastinal tumor recurred. The radiography of this case resembles left upper lobe lung cancer with mediastinal lymph node metastasis. Because this tumor lacks fat, the enhanced CT indicated that it was malignant but failed to identify it as a perivascular epithelioid cell neoplasm.This case reminds clinicians that, although most PEComa are benign, some can be malignant. As the radiology indicated, chest PEComas lack fat, which makes their preoperative diagnosis difficult. Therefore, needle biopsy is valuable for a definitive diagnosis.

Malignant Perivascular Epithelioid Cell Neoplasm of the Mediastinum and the Lung

PubMed Central

Liang, Wenjie; Xu, Shunliang; Chen, Feng

2015-01-01

Abstract A perivascular epithelioid cell neoplasm (PEComa) in the chest is rare, let alone in the mediastinum and lung. A 63-year-old man was admitted to our hospital with chest pain for more than 2 months and was found to have an opacity in his mediastinum and lung for 3 weeks. Enhanced chest computed tomography (CT) revealed a mass in both the left upper lobe and central anterior mediastinum. To identify the disease, a CT-guided percutaneous transthoracic needle biopsy of the upper left lung lesions was performed. The pathology result was consistent with epithelioid angiomyolipoma/PEComa. After a standard preparation for surgery, the neoplasms in the mediastinum and left lung were resected. The operative findings revealed extensive mediastinal tumor invasion in parts adjacent to the pericardium, including the mediastinal pleura, left pulmonary artery and vein, and phrenic nerve. The left lung tumor had invaded the lung membranes. The final pathologic diagnosis was malignant epithelioid angioleiomyoma in the left upper lung and mediastinum. Later, the mediastinal tumor recurred. The radiography of this case resembles left upper lobe lung cancer with mediastinal lymph node metastasis. Because this tumor lacks fat, the enhanced CT indicated that it was malignant but failed to identify it as a perivascular epithelioid cell neoplasm. This case reminds clinicians that, although most PEComa are benign, some can be malignant. As the radiology indicated, chest PEComas lack fat, which makes their preoperative diagnosis difficult. Therefore, needle biopsy is valuable for a definitive diagnosis. PMID:26039123

Neurophysiology of spontaneous facial expressions: I. Motor control of the upper and lower face is behaviorally independent in adults.

PubMed

Ross, Elliott D; Gupta, Smita S; Adnan, Asif M; Holden, Thomas L; Havlicek, Joseph; Radhakrishnan, Sridhar

2016-03-01

Facial expressions are described traditionally as monolithic entities. However, humans have the capacity to produce facial blends, in which the upper and lower face simultaneously display different emotional expressions. This, in turn, has led to the Component Theory of facial expressions. Recent neuroanatomical studies in monkeys have demonstrated that there are separate cortical motor areas for controlling the upper and lower face that, presumably, also occur in humans. The lower face is represented on the posterior ventrolateral surface of the frontal lobes in the primary motor and premotor cortices and the upper face is represented on the medial surface of the posterior frontal lobes in the supplementary motor and anterior cingulate cortices. Our laboratory has been engaged in a series of studies exploring the perception and production of facial blends. Using high-speed videography, we began measuring the temporal aspects of facial expressions to develop a more complete understanding of the neurophysiology underlying facial expressions and facial blends. The goal of the research presented here was to determine if spontaneous facial expressions in adults are predominantly monolithic or exhibit independent motor control of the upper and lower face. We found that spontaneous facial expressions are very complex and that the motor control of the upper and lower face is overwhelmingly independent, thus robustly supporting the Component Theory of facial expressions. Seemingly monolithic expressions, be they full facial or facial blends, are most likely the result of a timing coincident rather than a synchronous coordination between the ventrolateral and medial cortical motor areas responsible for controlling the lower and upper face, respectively. In addition, we found evidence that the right and left face may also exhibit independent motor control, thus supporting the concept that spontaneous facial expressions are organized predominantly across the horizontal facial axis and secondarily across the vertical axis. Published by Elsevier Ltd.

SRTM Stereo Pair: Meseta de Somuncura, Patagonia, Argentina

NASA Image and Video Library

2000-07-27

The Meseta de Somuncura is a semi-arid basalt plateau in northern Patagonia. This view of the northwestern part of the plateau, near Los Menucos, Argentina, shows numerous depressions where the upper basalt layers are missing or collapsed.

SU-G-JeP1-06: Correlation of Lung Tumor Motion with Tumor Location Using Electromagnetic Tracking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muccigrosso, D; Maughan, N; Parikh, P

Purpose: It is well known that lung tumors move with respiration. However, most measurements of lung tumor motion have studied long treatment times with intermittent imaging; those populations may not necessarily represent conventional LINAC patients. We summarized the correlation between tumor motion and location in a multi-institutional trial with electromagnetic tracking, and identified the patient cohort that would most benefit from respiratory gating. Methods: Continuous electromagnetic transponder data (Varian Medical, Seattle, WA) of lung tumor motion was collected from 14 patients (214 total fractions) across 3 institutions during external beam radiation therapy in a prospective clinical trial (NCT01396551). External interventionmore » from the clinician, such as couch shifts, instructed breath-holds, and acquisition pauses, were manually removed from the 10 Hz tracking data according to recorded notes. The average three-dimensional displacement from the breathing cycle’s end-expiratory to end-inhalation phases (peak-to-peak distance) of the transponders’ isocenter was calculated for each patient’s treatment. A weighted average of each isocenter was used to assess the effects of location on motion. A total of 14 patients were included in this analysis, grouped by their transponders’ location in the lung: upper, medial, and lower. Results: 8 patients had transponders in the upper lung, and 3 patients each in the medial lobe and lower lung. The weighted average ± standard deviation of all peak-to-peak distances for each group was: 1.04 ± 0.39 cm in the lower lung, 0.56 ± 0.14 cm in the medial lung, and 0.30 ± 0.06 cm in the upper lung. Conclusion: Tumors in the lower lung are most susceptible to excessive motion and daily variation, and would benefit most from continuous motion tracking and gating. Those in the medial lobe might be at moderate risk. The upper lobes have limited motion. These results can guide different motion management strategies between lung tumor locations. This is part of an NIH-funded prospective clinical trial (NCT01396551), using an electromagnetic transponder tracking system and additional funding from Varian Medical (Seattle, WA).« less

Spherically symmetric solutions and gravitational collapse in brane-worlds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heydari-Fard, Malihe; Sepangi, Hamid R., E-mail: heydarifard@qom.ac.ir, E-mail: hr-sepangi@sbu.ac.ir

2009-02-15

We consider spherically symmetric solutions within the context of brane-world theory without mirror symmetry or any form of junction conditions. For a constant curvature bulk, we obtain the modified Tolman-Oppenheimer-Volkoff (TOV) interior solutions in two cases where one is matched to a schwarzschild-de Sitter exterior while the other is consistent with an exterior solution whose structure can be used to explain the galaxy rotation curves without postulating dark matter. We also find the upper bound to the mass of a static brane-world star and show that the influence of the bulk effects on the interior solutions is small. Finally, wemore » investigate the gravitational collapse on the brane and show that the exterior of a collapsing star can be static in this scenario.« less

Long-term exercising video-endoscopic examination of the upper airway following laryngoplasty surgery: a prospective cross-sectional study of 41 horses.

PubMed

Barnett, T P; O'Leary, J M; Parkin, T D H; Dixon, P M; Barakzai, S Z

2013-09-01

To investigate upper respiratory tract function in horses, previously undergoing laryngoplasty (LP), using exercising video-endoscopy. To evaluate arytenoid abduction and stability, diagnose any concurrent upper airway problems, and correlate these with the owners' perception of success. Horses undergoing LP during a 6-year period at one hospital were initially included. Those available for re-examination were exercised for a duration and intensity considered maximal for their discipline using an over-ground endoscope. Resting and exercising laryngeal and pharyngeal videos were analysed blindly. Multivariable analysis was used to test associations between resting and exercising endoscopic variables, and also between endoscopic variables and owner questionnaire findings. Forty-one horses were included and 78% had a form of upper airway collapse at exercise, with 41% having complex forms, despite 93% of owners reporting the surgery to have been beneficial. Horses with poor abduction (grades 4 or 5/5) were 6 times more likely to make respiratory noise compared with those with good (grades 2 or 3/5) abduction (P = 0.020; 95% confidence interval [CI] 1.3-27.0), and those not having a ventriculectomy were 4.9 times more likely to produce respiratory noise post operatively (P = 0.048; 95% CI 1.0-23.9). Palatal dysfunction was observed in 24% of horses at rest, and 56% at exercise, with the diagnosis at rest and exercise significantly associated (P = 0.001). Increasing severity of pharyngeal lymphoid hyperplasia (prevalence 61%) was significantly associated with increasing arytenoid abduction (P = 0.01). Thirty-four per cent of horses had aryepiglottic fold collapse and 22% of horses had vocal fold collapse. Many horses that had previously had LP were diagnosed with upper airway abnormalities, despite the procedure being considered as beneficial by most owners. When investigating cases of ongoing respiratory noise or poor performance following LP, exercising endoscopy must be considered. Continued respiratory noise may be associated with poor arytenoid abduction and not performing concurrent ventriculectomy. © 2012 EVJ Ltd.

Motion and volumetric change as demonstrated by 4DCT: The effects of abdominal compression on the GTV, lungs, and heart in lung cancer patients.

PubMed

Rasheed, Abdullah; Jabbour, Salma K; Rosenberg, Stephen; Patel, Ajay; Goyal, Sharad; Haffty, Bruce G; Yue, Ning J; Khan, Alvin

2016-01-01

Lung tumors move during respiration, complicating radiation therapy. The abdominal compression plate (ACP) is thought to reduce respiratory motion. This study quantifies ACP efficacy on respiratory-induced motion by using 4-dimensional computed tomography to evaluate volume and displacement changes of the heart, lungs, and tumor with and without ACP. Lung cancer patients (n = 17) received 4-dimensional computed tomography simulations (10 computed tomography scans from 0% to 90% breathing phases) with and without ACP under maximally tolerated diaphragmatic pressure. Gross tumor volume (GTV), heart, and lungs were contoured in treatment planning software for each phase. Structures were exported for analysis. For each phase, with and without ACP, tumor and organ absolute centroid range of motion and volume were calculated. ACP did not significantly affect GTV, heart, or lung motion on the sample as a whole, but instead demonstrated patient-specific results. ACP reduced GTV motion in 3 (17.6%; 3 upper lobe tumors) by 2.9 mm (P < .01), increased motion in 5 (29.4%; 3 upper lobe tumors, 1 middle lobe, 1 lower lobe) by 1.9 mm (P < .03), and did not significantly change 9. Of the 3 patients exhibiting significantly decreased GTV motion, GTV, heart, and lung range of motion was 7.4 mm, 11.8 mm, and 11.9 mm, respectively, without compression and 4.5 mm, 8.4 mm, and 10.9 mm, respectively, with compression. Averaged across the sample, ACP did not exhibit any axis-specific effect. ACP efficacy was patient-specific, possibly because of pre-existing factors including chronic obstructive pulmonary disease severity, chest wall elasticity, tumor location, and patient comfort. Tumor lobe location does not predetermine compression efficacy; therefore, patients should be simulated with and without ACP, regardless of tumor location. GTV motion seems most important in determining suitability for compression. Alternative motion control should be considered in patients not benefited by compression. In patients who benefited, ACP may enhance tumor coverage while minimizing toxicity. Larger scale studies are necessary for definitive treatment recommendations. Copyright © 2016 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

Double-coronal X-Ray and Microwave Sources Associated with a Magnetic Breakout Solar Eruption

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Yao; Wu, Zhao; Zhao, Di

Double-coronal hard X-ray (HXR) sources are believed to be critical observational evidence of bi-directional energy release through magnetic reconnection in large-scale current sheets in solar flares. Here, we present a study on double-coronal sources observed in both HXR and microwave regimes, revealing new characteristics distinct from earlier reports. This event is associated with a footpoint-occulted X1.3-class flare (2014 April 25, starting at 00:17 UT) and a coronal mass ejection that were likely triggered by the magnetic breakout process, with the lower source extending upward from the top of the partially occulted flare loops and the upper source co-incident with rapidlymore » squeezing-in side lobes (at a speed of ∼250 km s{sup −1} on both sides). The upper source can be identified at energies as high as 70–100 keV. The X-ray upper source is characterized by flux curves that differ from those of the lower source, a weak energy dependence of projected centroid altitude above 20 keV, a shorter duration, and an HXR photon spectrum slightly harder than those of the lower source. In addition, the microwave emission at 34 GHz also exhibits a similar double-source structure and the microwave spectra at both sources are in line with gyrosynchrotron emission given by non-thermal energetic electrons. These observations, especially the co-incidence of the very-fast squeezing-in motion of side lobes and the upper source, indicate that the upper source is associated with (and possibly caused by) this fast motion of arcades. This sheds new light on the origin of the corona double-source structure observed in both HXRs and microwaves.« less

Pigments in sediments beneath recently collapsed ice shelves: The case of Larsen A and B shelves, Antarctic Peninsula

NASA Astrophysics Data System (ADS)

Sañé, E.; Isla, E.; Grémare, A.; Gutt, J.; Vétion, G.; DeMaster, D. J.

2011-01-01

In March 2002, 3200 km 2 of the Larsen B ice shelf collapsed off the Eastern Antarctic Peninsula (EAP). In the austral summer of 2006, sea floor sediment was recovered beneath the extinct Larsen B ice shelf and in a region off the Northern Antarctic Peninsula (NAP), which has been free of ice shelves for more than 1000 yr. To assess changes in the chemical composition of the sediment after ice shelf collapses, chlorophylls and pheophytins were measured in sediment cores at six stations. This is the first time that chlorophyll pigments have been analysed in sediment samples from regions under recently collapsed ice shelves. Five years after the ice shelf collapse, Chla and Chlc concentrations were similar in the interfacial sediment (upper 1 cm) of NAP and EAP regions. However, in EAP Chla and Chlc concentrations decreased more rapidly with depth in the sediment column and were negligible below 2 cm depth. The high Chla to Pheoa ratios indicated that sedimentary pigments found in EAP had undergone limited degradation suggesting that they were locally produced rather than laterally advected. Complementary information from excess 210Pb activity and diatom valve distributions provided further evidence that the pigment fluxes to the seabed in EAP took place only after the ice shelf collapse.

Earth Observations taken by the Expedition 17 Crew

NASA Image and Video Library

2008-04-29

ISS017-E-005763 (29 April 2008) --- Lake Pontchartrain and the Bonnet Carre Spillway, Louisiana, are featured in this image photographed by an Expedition 17 crewmember on the International Space Station. Lake Pontchartrain, a big body of water immediately north of New Orleans, occupies the upper part of this view, with the winding course of the muddy Mississippi River snaking across the bottom of the image (flow is east, from left to right). The city of New Orleans is sandwiched between the lake and river. Heavy rain in March and April 2008 in the Mississippi's catchment area raised water levels in the river sufficiently to make the Army Corps of Engineers take action. To reduce the volume of the river where it passes through New Orleans, the Corps opened the Bonnet Carre Spillway (lower left), a major engineering structure 18 kilometers upriver from New Orleans. The spillway, a 1.6 kilometer-wide gap in the developments along the Mississippi levees, is an integral part of the river and canal system that allows Mississippi river water to flow into Lake Pontchartrain. The spillway control structure itself is visible as a thin, discontinuous, white line along the river's edge in this image. The spillway has only been opened eight times since 1937. News of the opening in April 2008 was transmitted to crewmembers aboard the International Space Station who managed to capture the immediate effect of muddy water flowing down the spillway and into Lake Pontchartrain, where it forms great brown lobes in the otherwise green water. These lobes moved slowly east along the New Orleans shoreline, where the line of the Lake Pontchartrain Causeway, the longest bridge in the U.S., can be seen, top right. Opening the spillway protects New Orleans in various ways. First, it reduces pressure on the levees, which famously collapsed at some points during the onslaught of Hurricane Katrina in 2005. Keeping water levels below critical high levels also helps the river channel to accommodate the discharge of water, and reduces both the speed of flow and cross currents in the river which can interfere with vessels navigating the river -- or even cause collisions with levees.

Towards numerical simulations of fluid-structure interactions for investigation of obstructive sleep apnea

NASA Astrophysics Data System (ADS)

Huang, Chien-Jung; White, Susan M.; Huang, Shao-Ching; Mallya, Sanjay; Eldredge, Jeff D.

2014-11-01

Obstructive sleep apnea(OSA) is a medical condition characterized by repetitive partial or complete occlusion of the airway during sleep. The soft tissues in the airway of OSA patients are prone to collapse under the low pressure loads incurred during breathing. The numerical simulation with patient-specific upper airway model can provide assistance for diagnosis and treatment assessment. The eventual goal of this research is the development of numerical tool for air-tissue interactions in the upper airway of patients with OSA. This tool is expected to capture collapse of the airway in respiratory flow conditions, as well as the effects of various treatment protocols. Here, we present our ongoing progress toward this goal. A sharp-interface embedded boundary method is used on Cartesian grids for resolving the air-tissue interface in the complex patient-specific airway geometries. For the structure simulation, a cut-cell FEM is used. Non-linear Green strains are used for properly resolving the large tissue displacements in the soft palate structures. The fluid and structure solvers are strongly coupled. Preliminary results will be shown, including flow simulation inside the 3D rigid upper airway of patients with OSA, and several validation problem for the fluid-structure coupling.

Observations of the giant radio lobes region of Centaurus A with SAS 3

NASA Technical Reports Server (NTRS)

Marshall, F. J.; Clark, G. W.

1981-01-01

Observations of the X-ray flux from the extended radio lobes of the galaxy Centaurus A obtained with the SAS 3 observatory are reported. The 15 x 15 deg region that includes the lobes was mapped by superposing data from raster scans with the horizontal tubular collimator detectors, which have a 1.7 deg FWHM circular field of view. Data obtained is consistent with the presence of superposed emission from the point sources NGC 5128 and MX 1312-42, a previously unreported source detected by the Einstein Observatory IPC. Fluxes of 4.63 + or - 0.14 x 10 to the -10th and 4.6 + or - 0.6 x 10 to the -11th ergs/sq cm per sec were measured for NGC 5128 and MX 1312-42, respectively, with best fit power law spectra of indices 0.83 + or - 0.04 and 0.62 + or - 0.10 and hydrogen column densities of 1.23 + or - 0.10 x 10 to the 23rd and 9.7 + or - 15.0 x 10 to the 21st atoms/sq cm. Results imply an upper limit of 2.9 x 10 to the 11th for the X-ray emission from the extended radio lobes of Cen A between 2 and 10 keV, which indicates a lower limit to the magnetic field in the lobes of 1.6 x 10 to the -6th gauss.

Response to a combination of oxygen and a hypnotic as treatment for obstructive sleep apnoea is predicted by a patient's therapeutic CPAP requirement.

PubMed

Landry, Shane A; Joosten, Simon A; Sands, Scott A; White, David P; Malhotra, Atul; Wellman, Andrew; Hamilton, Garun S; Edwards, Bradley A

2017-08-01

Upper airway collapsibility predicts the response to several non-continuous positive airway pressure (CPAP) interventions for obstructive sleep apnoea (OSA). Measures of upper airway collapsibility cannot be easily performed in a clinical context; however, a patient's therapeutic CPAP requirement may serve as a surrogate measure of collapsibility. The present work aimed to compare the predictive use of CPAP level with detailed physiological measures of collapsibility. Therapeutic CPAP levels and gold-standard pharyngeal collapsibility measures (passive pharyngeal critical closing pressure (P crit ) and ventilation at CPAP level of 0 cmH 2 O (V passive )) were retrospectively analysed from a randomized controlled trial (n = 20) comparing the combination of oxygen and eszopiclone (treatment) versus placebo/air control. Responders (9/20) to treatment were defined as those who exhibited a 50% reduction in apnoea/hypopnoea index (AHI) plus an AHI<15 events/h on-therapy. Responders to treatment had a lower therapeutic CPAP requirement compared with non-responders (6.6 (5.4-8.1)  cmH 2 O vs 8.9 (8.4-10.4) cmH 2 O, P = 0.007), consistent with their reduced collapsibility (lower P crit , P = 0.017, higher V passive P = 0.025). Therapeutic CPAP level provided the highest predictive accuracy for differentiating responders from non-responders (area under the curve (AUC) = 0.86 ± 0.9, 95% CI: 0.68-1.00, P = 0.007). However, both P crit (AUC = 0.83 ± 0.11, 95% CI: 0.62-1.00, P = 0.017) and V passive (AUC = 0.77 ± 0.12, 95% CI: 0.53-1.00, P = 0.44) performed well, and the difference in AUC for these three metrics was not statistically different. A therapeutic CPAP level ≤8 cmH 2 O provided 78% sensitivity and 82% specificity (positive predictive value = 78%, negative predictive value = 82%) for predicting a response to these therapies. Therapeutic CPAP requirement, as a surrogate measure of pharyngeal collapsibility, predicts the response to non-anatomical therapy (oxygen and eszopiclone) for OSA. © 2017 Asian Pacific Society of Respirology.

Interhemispheric correlation of late pleistocene glacial events.

PubMed

Lowell, T V; Heusser, C J; Andersen, B G; Moreno, P I; Hauser, A; Heusser, L E; Schlüchter, C; Marchant, D R; Denton, G H

1995-09-15

A radiocarbon chronology shows that piedmont glacier lobes in the Chilean Andes achieved maxima during the last glaciation at 13,900 to 14,890, 21,000, 23,060, 26,940, 29,600, and >/=33,500 carbon-14 years before present ((14)C yr B.P.) in a cold and wet Subantarctic Parkland environment. The last glaciation ended with massive collapse of ice lobes close to 14,000(14)C yr B.P., accompanied by an influx of North Patagonian Rain Forest species. In the Southern Alps of New Zealand, additional glacial maxima are registered at 17,720(14)C yr B.P., and at the beginning of the Younger Dryas at 11,050 (14)C yr B. P. These glacial maxima in mid-latitude mountains rimming the South Pacific were coeval with ice-rafting pulses in the North Atlantic Ocean. Furthermore, the last termination began suddenly and simultaneously in both polar hemispheres before the resumption of the modern mode of deep-water production in the Nordic Seas. Such interhemispheric coupling implies a global atmospheric signal rather than regional climatic changes caused by North Atlantic thermohaline switches or Laurentide ice surges.

Novel Trocarless, Scarless Technique for Left Lobe Liver Retraction in Laparoscopic Upper Gastrointestinal Surgeries: Simple, Cost-effective and with Better Cosmesis.

PubMed

Madnani, Manish A; Patel, Tejas J; Gupta, Alankar K; Mistry, Jitendra H; Soni, Harshad N; Shah, Atul J; Patel, Kantilal S; Haribhakti, Sanjiv P

2015-12-01

Surgeons always look for ways to reduce the size and number of ports in laparoscopy, where in today's era, we have single-incision laparoscopic surgery (SILS). While doing so, principal 'adequate exposure' should not be compromised. For upper gastrointestinal laparoscopic surgeries, we have adopted a novel technique for retraction of the left lobe of liver, which is described here. Device can be made both single sling and double sling, with help of an infant feeding tube and any routinely used suture material. Placement of device does not require any incision, special energy source, or instrument. It can help in SILS. Detailed technique is described in the text. Operative times did not change significantly. Exposure was excellent. No special instruments or energy devices are required; thus, it is cost-effective. Reducing one port for liver retraction gives better cosmetic results. No liver injury due to the device was noticed in any of the cases. This technique is simpler and cheaper and also gives reasonable cosmetic results compared to other techniques described in the literature.

[Clinical problems in medical mycology: Problem number 52].

PubMed

Messina, Fernando; Depardo, Roxana; Negroni, Ricardo; Romero, Mercedes; Walker, Laura; Arechavala, Alicia; Marín, Emmanuel; Canteros, Cristina; Santiso, Gabriela

The case of a 60 year old woman with hemoptysis and a thin-walled cavitary lesion at the upper lobe of the right lung is presented. The woman presented at the Mycology Unit of the Muñiz Hospital in Buenos Aires City 3 months after the beginning of her clinical manifestations. A hyaline micelial fungus with chlamido-arthroconidias was isolated from the bronchoalveolar lavage. Immunodiffusion and counter-immnunoelectrophoresis with coccidioidin and histoplasmin rendered positive results against both antigents, and skin tests with coccidioidin and histoplasmin were also positive with strong reactions. The isolated fungus was identified as Coccidioides posadasii at the National Microbiology Institute Carlos Malbrán, by means of a molecular technique. The patient was treated with itraconazole by oral route at a daily dose of 200mg with good clinical response, but due to the persistence of the lung cavity, a surgical removal of the upper lobe of the right lung had to be scheduled. Copyright © 2017 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.

Terraced margins of inflated lava flows on Earth and Mars

NASA Astrophysics Data System (ADS)

Zimbelman, J. R.; Garry, W. B.; Bleacher, J. E.; Crumpler, L. S.

2011-12-01

When fluid basaltic lava flows are emplaced over a shallow regional slope (typically much less than one degree), the lava flows often display impressive characteristics of inflation. Here we describe a distinctive marginal characteristic that is often developed along the margins of endogenously inflated basaltic lava flows; discreet topographic levels of the emplaced lava that are here termed 'terraced margins'. Terraced margins were first noted at the distal end of the Carrizozo lava flow in central New Mexico, where they are particularly well expressed, but terraces have also been observed along some margins of the McCartys lava flow (NM), the distal end of the 1859 Mauna Loa lava flow (HI), and lava flows at Craters of the Moon (ID). Differential Global Positioning System surveys across several terraced margins reveal consistent topographic characteristics: the upper surface of each terrace level is at roughly one half the height of the sheet lobe from which it emerges; when a terrace becomes the source of an additional outbreak, the upper surface of the second terrace is at roughly one half the height of the source terrace; often a subtle topographic depression is present along the contact between a terrace and its source sheet lobe, suggesting that the terrace outflow starts at a level roughly one-third the height of the source lobe; the upper surfaces of both the source sheet lobe and associated terraces are level to within tens of centimeters across length scales of many tens to hundreds of meters, indicative of inflation of all components. The field observations will be used as the constraints for modeling of the inflation and terracing mechanisms, an effort that has only recently started. The multiple imaging data sets now available for Mars have revealed the presence of terraced margins on some lava flows on Mars. Although detailed topographic data are not currently available for the Martian examples identified so far, the presence of terraced margins for lava flows on both Earth and Mars indicates that the terracing mechanism is intimately associated with the lava flow inflation process. This work was supported by grants from the Planetary Geology and Geophysics program of NASA (NNX09AD88G) and the Scholarly Studies program of the Smithsonian Institution.

Therapeutic value of lymph node dissection for right middle lobe non-small-cell lung cancer

PubMed Central

Kuroda, Hiroaki; Mun, Mingyon; Motoi, Noriko; Ishikawa, Yuichi; Nakagawa, Ken; Yatabe, Yasushi; Okumura, Sakae

2016-01-01

Background Superior mediastinal and #11i lymph node (LN) metastases are adverse prognostic factors in patients with middle lobe lung cancer. We aimed to clarify the benefit of thorough lymphadenectomy by LN station or zone in middle lobe non-small-cell lung cancer (NSCLC). Methods Among 295 patients who underwent pulmonary resection and thorough lymphadenectomy for primary right middle lobe (RML) NSCLC at two institutions, we enrolled 68 patients (33 men, 35 women) and retrospectively studied their data. We divided each N1 location (i.e., #10, #11s and #11i) into N1(−)N2(+) and N1(+)N2(+) and divided the #12m location into N1(+)N2(−), N1(−)N2(+) and N1(+)N2(+). Results Interlobar node involvement was rare in pN1 NSCLC when compared with that in other N1 nodes. Lymph node dissection (LND) was beneficial when the hilar zone (HZ)/interlobar zone (IZ) LNs were located at the intermediate point of the upper zones (UZs) and subcarinal zones (SCZs), with the therapeutic benefit at the SCZ being 2.8-fold higher than that at the UZ and 9.7-fold higher than that at the lower zone (LZ). Furthermore, LND evidently had greater therapeutic value for the SCZ than the UZ, which was compatible with skip N2 metastases. Conclusions For middle lobe NSCLC, mediastinal LND should be considered a priority in the SCZ than in the UZ. Moreover, the HZ/IZ is central to unfavourable prognoses in patients with pN2 middle lobe NSCLC. PMID:27162652

Clinical value of CT-based preoperative software assisted lung lobe volumetry for predicting postoperative pulmonary function after lung surgery

NASA Astrophysics Data System (ADS)

Wormanns, Dag; Beyer, Florian; Hoffknecht, Petra; Dicken, Volker; Kuhnigk, Jan-Martin; Lange, Tobias; Thomas, Michael; Heindel, Walter

2005-04-01

This study was aimed to evaluate a morphology-based approach for prediction of postoperative forced expiratory volume in one second (FEV1) after lung resection from preoperative CT scans. Fifteen Patients with surgically treated (lobectomy or pneumonectomy) bronchogenic carcinoma were enrolled in the study. A preoperative chest CT and pulmonary function tests before and after surgery were performed. CT scans were analyzed by prototype software: automated segmentation and volumetry of lung lobes was performed with minimal user interaction. Determined volumes of different lung lobes were used to predict postoperative FEV1 as percentage of the preoperative values. Predicted FEV1 values were compared to the observed postoperative values as standard of reference. Patients underwent lobectomy in twelve cases (6 upper lobes; 1 middle lobe; 5 lower lobes; 6 right side; 6 left side) and pneumonectomy in three cases. Automated calculation of predicted postoperative lung function was successful in all cases. Predicted FEV1 ranged from 54% to 95% (mean 75% +/- 11%) of the preoperative values. Two cases with obviously erroneous LFT were excluded from analysis. Mean error of predicted FEV1 was 20 +/- 160 ml, indicating absence of systematic error; mean absolute error was 7.4 +/- 3.3% respective 137 +/- 77 ml/s. The 200 ml reproducibility criterion for FEV1 was met in 11 of 13 cases (85%). In conclusion, software-assisted prediction of postoperative lung function yielded a clinically acceptable agreement with the observed postoperative values. This method might add useful information for evaluation of functional operability of patients with lung cancer.

Using virtual reality simulation to assess competence in video-assisted thoracoscopic surgery (VATS) lobectomy.

PubMed

Jensen, Katrine; Bjerrum, Flemming; Hansen, Henrik Jessen; Petersen, René Horsleben; Pedersen, Jesper Holst; Konge, Lars

2017-06-01

The societies of thoracic surgery are working to incorporate simulation and competency-based assessment into specialty training. One challenge is the development of a simulation-based test, which can be used as an assessment tool. The study objective was to establish validity evidence for a virtual reality simulator test of a video-assisted thoracoscopic surgery (VATS) lobectomy of a right upper lobe. Participants with varying experience in VATS lobectomy were included. They were familiarized with a virtual reality simulator (LapSim ® ) and introduced to the steps of the procedure for a VATS right upper lobe lobectomy. The participants performed two VATS lobectomies on the simulator with a 5-min break between attempts. Nineteen pre-defined simulator metrics were recorded. Fifty-three participants from nine different countries were included. High internal consistency was found for the metrics with Cronbach's alpha coefficient for standardized items of 0.91. Significant test-retest reliability was found for 15 of the metrics (p-values <0.05). Significant correlations between the metrics and the participants VATS lobectomy experience were identified for seven metrics (p-values <0.001), and 10 metrics showed significant differences between novices (0 VATS lobectomies performed) and experienced surgeons (>50 VATS lobectomies performed). A pass/fail level defined as approximately one standard deviation from the mean metric scores for experienced surgeons passed none of the novices (0 % false positives) and failed four of the experienced surgeons (29 % false negatives). This study is the first to establish validity evidence for a VATS right upper lobe lobectomy virtual reality simulator test. Several simulator metrics demonstrated significant differences between novices and experienced surgeons and pass/fail criteria for the test were set with acceptable consequences. This test can be used as a first step in assessing thoracic surgery trainees' VATS lobectomy competency.

Loamy, two-storied soils on the outwash plains of southwestern lower Michigan: Pedoturbation of loess with the underlying sand

USGS Publications Warehouse

Luehmann, Michael D.; Peter, Brad G.; Connallon, Christopher B.; Schaetzl, Randall J.; Smidt, Samuel J.; Liu, Wei; Kincare, Kevin A.; Walkowiak, Toni A.; Thorlund, Elin; Holler, Marie S.

2016-01-01

Soils on many of the outwash plains in southwestern Michigan have loamy upper profiles, despite being underlain by sand-textured outwash. The origin of this upper, loamy material has long been unknown. The purpose of this study is to analyze the spatio-textural characteristics of these loamy-textured sediments to ascertain their origin(s). The textural curves of this material have distinct bimodality, with clear silt and sand peaks. Because the sand peaks align with those in the outwash below, we conclude that the upper material is a mixture of an initially silty material with the sand from below, forming loamy textures. By applying a textural filtering operation to the data, we determined its original characteristics; nearly all of the soils originally had silt loam upper profiles, typical for loess. Field data showed that the loamy material is thickest east of a broad, north–south trending valley (the Niles-Thornapple Spillway) that once carried glacial meltwater. The material becomes thinner, generally better sorted, and finer in texture eastward, away from this channel. We conclude that the loamy mantle on many of the adjacent outwash plains is silt-rich loess, derived from the Niles-Thornapple Spillway and its tributary channels and transported on mainly westerly winds. The spillway was active between ca. 17.3 and 16.8 k cal. years ago. At this time, a large network of tunnel channels existed beneath the stagnant Saginaw lobe ice. Meltwater from the lobe funneled silt-rich sediment into the spillway, rendering it a prodigious silt source.

Complex layering of the Orange Mountain Basalt: New Jersey, USA

NASA Astrophysics Data System (ADS)

Puffer, John H.; Block, Karin A.; Steiner, Jeffrey C.; Laskowich, Chris

2018-06-01

The Orange Mountain Basalt of New Jersey is a Mesozoic formation consisting of three units: a single lower inflated sheet lobe about 70 m thick (OMB1), a middle pillow basalt about 10 to 20 m thick (OMB2), and an upper compound pahoehoe flow about 20 to 40 m thick (OMB3). The Orange Mountain Basalt is part of the Central Atlantic Magmatic Province. Quarry and road-cut exposures of OMB1 near Paterson, New Jersey, display some unusual layering that is the focus of this study. OMB1 exposures displays the typical upper crust, core, and basal crust layers of sheet lobes but throughout the Patterson area also display distinct light gray layers of microvesicular basalt mineralized with albite directly over the basal crust and under the upper crust. The lower microvesicular layer is associated with mega-vesicular diapirs. We propose that the upper and lower microvesicular layers were composed of viscous crust that was suddenly quenched before it could devolatilize immediately before the solidification of the core. During initial cooling, the bottom of the basal layer was mineralized with high concentrations of calcite and albite during a high-temperature hydrothermal event. Subsequent albitization, as well as zeolite, prehnite, and calcite precipitation events, occurred during burial and circulation of basin brine heated by recurring Palisades magmatism below the Orange Mountain Basalt. Some of the events experienced by the Orange Mountain Basalt are unusual and place constraints on the fluid dynamics of thick flood basalt flows in general. The late penetration of vesicular diapirs through the entire thickness of the flow interior constrains its viscosity and solidification history.

A shift in the biogenic silica of sediment in the Larsen B continental shelf, off the Eastern Antarctic Peninsula, resulting from climate change.

PubMed

Sañé, Elisabet; Isla, Enrique; Bárcena, María Ángeles; DeMaster, David J

2013-01-01

In 2002, section B of the Larsen ice shelf, off of the Eastern Antarctic Peninsula, collapsed and created the opportunity to study whether the changes at the sea surface left evidence in the sedimentary record. Biogenic silica is major constituent of Antarctic marine sediment, and its presence in the sediment column is associated with diatom production in the euphotic zone. The abundance of diatom valves and the number of sponge spicules in the biogenic silica was analyzed to determine how the origin of the biogenic silica in the upper layers of the sediment column responded to recent environmental changes. Diatom valves were present only in the upper 2 cm of sediment, which roughly corresponds to the period after the collapse of the ice shelf. In contrast, sponge spicules, a more robust form of biogenic silica, were also found below the upper 2 cm layer of the sediment column. Our results indicate that in this region most of the biogenic silica in the sedimentary record originated from sponge spicules rather than diatoms during the time when the sea surface was covered by the Larsen ice shelf. Since the collapse of the ice shelf, the development of phytoplankton blooms and the consequent influx of diatom debris to the seabed have shifted the biogenic silica record to one dominated by diatom debris, as occurs in most of the Antarctic marine sediment. This shift provides further evidence of the anthropogenic changes to the benthic habitats of the Antarctic and will improve the interpretation of the sedimentary record in Polar Regions where these events occur.

Convective radiation fluid-dynamics: formation and early evolution of ultra low-mass objects

NASA Astrophysics Data System (ADS)

Wuchterl, G.

2005-12-01

The formation process of ultra low-mass objects is some kind of extension of the star formation process. The physical changes towards lower mass are discussed by investigating the collapse of cloud cores that are modelled as Bonnor-Ebert spheres. Their collapse is followed by solving the equations of fluid dynamics with radiation and a model of time-dependent convection that has been calibrated to the Sun. For a sequence of cloud-cores with 1 to 0.01 solar masses, evolutionary tracks and isochrones are shown in the mass-radius diagram, the Hertzsprung-Russel diagram and the effective temperature-surface gravity or Kiel diagram. The collapse and the early hydrostatic evolution to ages of few Ma are briefly discussed and compared to observations of objects in Upper Scorpius and the low-mass components of GG Tau.

[Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].

PubMed

Stănciulea, Oana; Preda, Carmen; Herlea, V; Popa, Monica; Ulmeanu, D; Vasilescu, C

2007-01-01

We present the case of a 52 years old man, with significant familial history, diagnosed with familial adenomatous polyposis-attenuated form, with no clinical and endoscopic surveillance until 2001 when he was admitted for an upper gastrointestinal haemorrhage episode. Upper gastrointestinal scopy revealed duodenal adenomatous polyps and gastric hyperplastic polyps. The patient underwent duodenopancreatectomy with total gastrectomy. The histopathological exam revealed duodenal G2 adenocarcinoma pT3N0, and gastric hyperplastic polyps with no signs of dysplasia. The surgical procedure was followed by chemotherapy. In 2002 the patient was admitted for rectal bleeding and colonoscopy showed 2 sigmoid polyps, appropriate for endoscopic removal and a poly-lobate polyp in the transverse colon. The patient underwent transverse colectomy (the histopathological exam--in situ carcinoma). March 2003--the patient underwent endoscopic removal for a rectal polyp (histopathological exam: moderate dysplasia). In 2005 was noted a pulmonary nodule, located in the postero-apical segment of upper left lobe, for which left superior lobe resection was performed (the histopathological exam: metastatic adenocarcinoma). In May 2006 was performed an exploratory laparotomy. Intraoperatively were noted: peritoneal carcinomatosis and multiple liver metastasis. The surgical procedure recommended in patients with attenuated form of familial adenomatous polyposis and suspect periampullary lesions is duodenopancreatectomy. The particularity of the case is the association of total gastrectomy for gastric hyperplastic polyps.

Ictal semiology in hippocampal versus extrahippocampal temporal lobe epilepsy.

PubMed

Gil-Nagel, A; Risinger, M W

1997-01-01

We have analysed retrospectively the clinical features and electroencephalograms in 35 patients with complex partial seizures of temporal lobe origin who were seizure-free after epilepsy surgery. Two groups were differentiated for statistical analysis: 16 patients had hippocampal temporal lobe seizures (HTS) and 19 patients had extrahippocampal temporal lobe seizures (ETS) associated with a small tumour of the lateral or inferior temporal cortex. All patients in the HTS group had ictal onset verified with intracranial recordings (depth or subdural electrodes). In the ETS group, extrahippocampal onset was verified with intracranial recordings in eight patients and assumed, because of failure of a previous amygdalohippocampectomy, in one patient. Historical information, ictal semiology and ictal EEG of typical seizures were analysed in each patient. The occurrence of early and late oral automatisms and dystonic posturing of an upper extremity was analysed separately. A prior history of febrile convulsions was obtained in 13 HTS patients (81.3%) but in none with ETS (P < 0.0001, Fisher's exact test). An epigastric aura preceded seizures in five patients with HTS (31.3%) and none with ETS (P = 0.0135, Fisher's exact test), while an aura with experiential content was recalled by nine patients with ETS (47.4%) and none with HTS (P = 0.0015), Fisher's exact test). Early oral automatisms occurred in 11 patients with HTS (68.8%) and in two with ETS (10.5%) (P = 0.0005, Fisher's exact test). Early motor involvement of the contralateral upper extremity without oral automatisms occurred in three patients with HTS (18.8%) and in 10 with ETS (52.6%) (P = 0.0298, Fisher's exact test). Arrest reaction, vocalization, speech, facial grimace, postictal cough, late oral automatisms and late motor involvement of the contralateral arm and hand occurred with similar frequency in both groups. These observations show that the early clinical features of HTS and ETS are different.

Left hepatic lobe herniation through an incisional anterior abdominal wall hernia and right adrenal myelolipoma: a case report and review of the literature.

PubMed

Nuño-Guzmán, Carlos M; Arróniz-Jáuregui, José; Espejo, Ismael; Valle-González, Jesús; Butus, Hernán; Molina-Romo, Alejandro; Orranti-Ortega, Rodrigo I

2012-01-10

Herniation of the liver through an anterior abdominal wall hernia defect is rare. To the best of our knowledge, only three cases have been described in the literature. A 70-year-old Mexican woman presented with a one-week history of right upper quadrant abdominal pain, nausea, vomiting, and jaundice to our Department of General Surgery. Her medical history included an open cholecystectomy from 20 years earlier and excessive weight. She presented with jaundice, abdominal distension with a midline surgical scar, right upper quadrant tenderness, and a large midline abdominal wall defect with dullness upon percussion and protrusion of a large, tender, and firm mass. The results of laboratory tests were suggestive of cholestasis. Ultrasound revealed choledocholithiasis. A computed tomography scan showed a protrusion of the left hepatic lobe through the anterior abdominal wall defect and a well-defined, soft tissue density lesion in the right adrenal topography. An endoscopic common bile duct stone extraction was unsuccessful. During surgery, the right adrenal tumor was resected first. The hernia was approached through a median supraumbilical incision; the totality of the left lobe was protruding through the abdominal wall defect, and once the lobe was reduced to its normal position, a common bile duct surgical exploration with multiple stone extraction was performed. Finally, the abdominal wall was reconstructed. Histopathology revealed an adrenal myelolipoma. Six months after the operation, our patient remains in good health. The case of liver herniation through an incisional anterior abdominal wall hernia in this report represents, to the best of our knowledge, the fourth such case reported in the literature. The rarity of this medical entity makes it almost impossible to specifically describe predisposing risk factors for liver herniation. Obesity, the right adrenal myelolipoma mass effect, and the previous abdominal surgery are likely to have contributed to incisional hernia formation.

Chest ultrasounds to guide manual reexpansion of a postoperative pulmonary atelectasis: a case report.

PubMed

Cavaliere, F; Biasucci, D; Costa, R; Soave, M; Addabbo, G; Proietti, R

2011-07-01

Reexpansion of a pulmonary atelectasis is often difficult, even after removing possible causes of bronchial obstruction. Chest ultrasounds, inexpensive and readily available at the patient bedside, may offer valuable support to guide recruitment maneuvers. We report the case of a 57-year-old woman that developed a complete collapse of the left lung seven days after undergoing an intestinal resection for perforation. A mucous plug occluding the main bronchus was removed with bronchoscopy, but persistent hypoxemia required mechanical ventilation; 24 hours later, an attempt to wean the patient from the ventilator failed. Chest X-rays revealed the persistence of a partial collapse of the left inferior lobe associated with a pleural effusion. A chest ultrasound confirmed the presence of a lung consolidation and of a modest pleural effusion. Manual reexpansion was then attempted, and ventilatory pressures as well as the duration of forced inspirations were based on real-time ultrasound images. Complete reexpansion was achieved within a few minutes and confirmed by chest X-ray. The patient was weaned from mechanical ventilation on the same day and discharged from ICU three days later.

76 FR 31451 - Special Conditions: Boeing Model 747-8 Airplanes; Stairway Between the Main Deck and Upper Deck

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

.... 3. With the airplane in level attitude and in each attitude resulting from the collapse of one or... during all flight phases. 14. ``No smoking'' and ``return to seat'' signs must be installed and visible...

The Edge

NASA Technical Reports Server (NTRS)

2006-01-01

6 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows the edge (running diagonally from the lower left to the upper right) of a trough, which is part of a large pit crater complex in Noachis Terra. This type of trough forms through the collapse of surface materials into the subsurface, and often begins as a series of individual pit craters. Over time, continued collapse increases the diameter of individual pits until finally, adjacent pits merge to form a trough such as the one captured in this image. The deep shadowed area is caused in part by an overhang; layered rock beneath this overhang is less resistant to erosion, and thus has retreated tens of meters backward, beneath the overhang. A person could walk up inside this 'cave' formed by the overhanging layered material.

Location near: 47.0oS, 355.7oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

Evaluation of the 3D Finite Element Method Using a Tantalum Rod for Osteonecrosis of the Femoral Head

PubMed Central

Shi, Jingsheng; Chen, Jie; Wu, Jianguo; Chen, Feiyan; Huang, Gangyong; Wang, Zhan; Zhao, Guanglei; Wei, Yibing; Wang, Siqun

2014-01-01

Background The aim of this study was to contrast the collapse values of the postoperative weight-bearing areas of different tantalum rod implant positions, fibula implantation, and core decompression model and to investigate the advantages and disadvantages of tantalum rod implantation in different ranges of osteonecrosis in comparison with other methods. Material/Methods The 3D finite element method was used to establish the 3D finite element model of normal upper femur, 3D finite element model after tantalum rod implantation into different positions of the upper femur in different osteonecrosis ranges, and other 3D finite element models for simulating fibula implant and core decompression. Results The collapse values in the weight-bearing area of the femoral head of the tantalum rod implant model inside the osteonecrosis area, implant model in the middle of the osteonecrosis area, fibula implant model, and shortening implant model exhibited no statistically significant differences (p>0.05) when the osteonecrosis range was small (60°). The stress values on the artificial bone surface for the tantalum rod implant model inside the osteonecrosis area and the shortening implant model exhibited statistical significance (p<0.01). Conclusions Tantalum rod implantation into the osteonecrosis area can reduce the collapse values in the weight-bearing area when osteonecrosis of the femoral head (ONFH) was in a certain range, thereby obtaining better clinical effects. When ONFH was in a large range (120°), the tantalum rod implantation inside the osteonecrosis area, shortening implant or fibula implant can reduce the collapse values of the femoral head, as assessed by other methods. PMID:25479830

Determination of design and operation parameters for upper atmospheric research instrumentation to yield optimum resolution with deconvolution, appendix 4

NASA Technical Reports Server (NTRS)

Ioup, George E.; Ioup, Juliette W.

1989-01-01

The power spectrum for a stationary random process can be defined with the Wiener-Khintchine Theorem, which says that the power spectrum and the auto correlation function are a Fourier transform pair. To implement this theorem for signals that are discrete and of finite length we can use the Blackman-Tukey method. Blackman and Tukey (1958) show that a function w(tau), called a lag window, can be applied to the auto correlation estimates to obtain power spectrum estimates that are statistically stable. The Fourier transform of w(r) is called a spectral window. Typical choices for spectral windows show a distinct trade-off between the main lobe width and side lobe strength. A new idea for designing windows by taking linear combinations of the standard windows to produce hybrid windows was introduced by Smith (1985). We implement Smith's idea to obtain spectral windows with narrow main lobes and smaller (compared with typical windows) near side lobes. One of the main contributions of this thesis is that we show that Smith's problem is equivalent to a Quadratic Programming (QP) problem with linear equality and inequality constraints. A computer program was written to produce hybrid windows by setting up and solving the QP problem. We also developed and solved two variations of the original problem. The two variations involved changing the inequality constraints in both cases from non negativity on the combination coefficients to non negativity on the hybrid lag window itself. For the second variation, the window functions used to construct the hybrid window were changed to a frequency-variable set of truncated cosinusoids. A series of tests was run with the three computer programs to investigate the behavior of the hybrid spectral and lag windows. Emphasis was put on obtaining spectral windows with both relatively narrow main lobes and the lowest possible (for these algorithms) near side lobes. Some success was achieved for this goal. A 10 dB peak side lobe reduction over the rectangular spectral window without significant main lobe broadening was achieved. Also, average side lobe levels of -117 dB were reached at a cost of doubling the main lobe width (at the -3 dB point).

Lateral Variability of Lava flow Morphologies in the Deccan Traps Large Igneous Province (India)

NASA Astrophysics Data System (ADS)

Vanderkluysen, L.; Rader, E. L.; Self, S.; Clarke, A. B.; Sheth, H.; Moyer, D. K.

2016-12-01

In continental flood basalt provinces (CFBs), lava flow morphologies have traditionally been classified in two distinct groups recognizable in the field, expressing two different modes of lava flow emplacement mechanisms: (a) compound lava flow fields dominated by meter-sized pāhoehoe toes and lobes; and (b) inflated sheet lobes tens to hundreds of meters in width and meters to tens of meters in height. Temporal transitions between these two emplacement styles have been recognized in many mafic large igneous provinces worldwide and seem to be a fundamental feature of CFBs. However, lateral variations in these morphologies remain poorly studied and understood. In the Deccan CFB of India, two principal hypotheses have been proposed to account for possible lateral variations in lava flow facies: that smaller toes and lobes occur in distal regions of flow fields, representing breakouts at the edges of larger inflated lavas; or on the contrary that smaller toes and lobes represent proximal facies. We conducted a field study focusing on two of the Deccan's formations, the Khandala and the Poladpur, located in the middle and upper sections of the province's defined chemostratigraphy. We studied nine sections along a 600 km long E-W transect, with the easternmost sections representing the most distal outcrops, ≥ 500 km away from inferred vents. The Khandala Formation is traditionally described as a sequence of three thick inflated sheet lobes in the well-exposed sections of the western Deccan. However, in the central Deccan, we find the Khandala to be much thicker overall, with half of its thickness dominated by small, meter-sized toes and lobes. Inflated sheet lobes of the Khandala are thinner on average in the central Deccan than further to the east or west. We document this transition as occurring progressively in outcrops only 80 km apart. In the Poladpur, the average thickness of inflated sheet lobes increases in distal outcrops of the eastern Deccan. We interpret these results as an indication that smaller, meter-sized toes and lobes are indicative of proximal facies, whereas the thickest (> 10 m) inflated sheet lobes are the most likely to reach the far edges of the province. Analogue experiments are currently under way to test the relative importance of eruption parameters in the development of these morphologies.

[Left ventricular projectile migration after an accidental close-range gunshot wound].

PubMed

Driessen, A; Tjardes, T; Eikermann, C; Trojan, S; Fröhlich, M; Grimaldi, G; Kosse, N

2016-07-01

We report the case of a 24-year-old female after sustaining a shotgun wound in the left upper extremity and chest. Initial emergency diagnostics revealed numerous shotgun pellets scattered throughout the left-side soft tissue, chest and upper lung lobe with one pellet having migrated into the left ventricle of the heart.Due to the devastating injury pattern, gunshot wounds are interdisciplinarily challenging and should include extended initial diagnostics, such as contrast agent CT. The potential toxicity of elevated lead blood levels have to be taken into further account.

Landslide in Coprates

NASA Technical Reports Server (NTRS)

2004-01-01

This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows part of a large landslide complex off the north wall of Coprates Chasma in the Valles Marineris trough complex. The wall of Coprates Chasma occupies much of the upper and middle portions of the image; the landslide lobes are on the trough floor in the bottom half of the image. Large boulders the size of houses can be seen on these landslide surfaces. This image is located near 13.9 S, 56.7 W. The picture covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the upper left.

Anatomical variations in lymphatic drainage of the right lung: applications in lung cancer surgery.

PubMed

Ndiaye, Assane; Di-Marino, V; Ba, P S; Ndiaye, Aï; Gaye, M; Nazarian, S

2016-12-01

To specify the topography and variations in lymphatic drainage of the right lung to the mediastinum and their therapeutic implications in non-small cell lung cancers (NSCLC). We injected a dye into the subpleural lymphatic vessels in 65 right lung segments, followed by dissection in 22 subjects. At the upper lobe, we had injected 32 segments. We noted extrasegmental overflow in one case; extrasegmental and extralobar drainage in two cases; drainage to the lymph nodes of another lobe in one case. Fifty-six percent of the segments drained directly (skipping intrapulmonary and hilar lymph nodes) into the right paratracheal lymph nodes, and one dorsal segment drained into the thoracic duct. A ventral segment drained into the inferior tracheobronchial lymph nodes. A contralateral drainage to the recurrent chain was observed in two cases. Sixteen segments of the middle lobe were injected and mainly drained into the inferior tracheobronchial lymph nodes with six direct paths; one medial segment drained into the right anterior mediastinal chain. We noted three contralateral drainages and eight downward abdominal drainages. Out of the 17 segments of the lower lobe injected, 6 segments drained into the lymph nodes of another lobe, 5 segments showed a direct route to the lower quadrant chains. We noted one time a drainage into the paraesophageal lymph nodes. The variations in lymphatic drainage of the right lung require to carry out systematically a radical mediastinal lymphadenectomy during the removal of non-small cell lung cancers and to associate an adjuvant treatment.

Immunocytochemical Mapping of an RDL-Like GABA Receptor Subunit and of GABA in Brain Structures Related to Learning and Memory in the Cricket Acheta domesticus

PubMed Central

Strambi, Colette; Cayre, Myriam; Sattelle, David B.; Augier, Roger; Charpin, Pierre; Strambi, Alain

1998-01-01

The distribution of putative RDL-like GABA receptors and of γ-aminobutyric acid (GABA) in the brain of the adult house cricket Acheta domesticus was studied using specific antisera. Special attention was given to brain structures known to be related to learning and memory. The main immunostaining for the RDL-like GABA receptor was observed in mushroom bodies, in particular the upper part of mushroom body peduncle and the two arms of the posterior calyx. Weaker immunostaining was detected in the distal part of the peduncle and in the α and β lobes. The dorso- and ventrolateral protocerebrum neuropils appeared rich in RDL-like GABA receptors. Staining was also detected in the glomeruli of the antennal lobe, as well as in the ellipsoid body of the central complex. Many neurons clustered in groups exhibit GABA-like immunoreactivity. Tracts that were strongly immunostained innervated both the calyces and the lobes of mushroom bodies. The glomeruli of the antennal lobe, the ellipsoid body, as well as neuropils of the dorso- and ventrolateral protocerebrum were also rich in GABA-like immuno- reactivity. The data demonstrated a good correlation between the distribution of the GABA-like and of the RDL-like GABA receptor immunoreactivity. The prominent distribution of RDL-like GABA receptor subunits, in particular areas of mushroom bodies and antennal lobes, underlines the importance of inhibitory signals in information processing in these major integrative centers of the insect brain. PMID:10454373

Structural Analysis of Silicic Lavas Reveals the Importance of Endogenous Flow During Emplacement

NASA Astrophysics Data System (ADS)

Andrews, G. D.; Martens, A.; Isom, S.; Maxwell, A.; Brown, S. R.

2017-12-01

Recent observations of silicic lava flows in Chile strongly suggest sustained, endogeneous flow beneath an insulating carapace, where the flow advances through breakouts at the flow margin. New mapping of vertical exposures around the margin of Obsidian Dome, California, has identified discreet lobe structures in cross-section, suggesting that flow-front breakouts occured there during emplacement. The flow lobes are identified through structural measurements of flow-banding orientation and the stretching directions of vesicles. Newly acquired lidar of the Inyo Domes, including Obsidian Dome, is being analyzed to better understand the patterns of folding on the upper surface of the lavas, and to test for fold vergence patterns that may distinguish between endogenous and exogenous flow.

Provenance, age, and environment of mid-Wisconsinan slackwater lake sediment in the St. Louis Metro East area, USA

USGS Publications Warehouse

Curry, B. Brandon; Grimley, D.A.

2006-01-01

Valleys tributary to the Mississippi River contain fossiliferous slackwater lake sediment (Equality Formation) deposited in response to aggradation of the Mississippi River valley during the last glaciation. In the St. Louis Metro East area, the lower part of the Equality Formation is primarily laminated, fossiliferous silt and clay deposited from about 44,150 to 24,310 14C yr B.P. The upper Equality Formation is primarily very fine sand to silt deposited from about 21,200 to 17,000 14C yr B.P. Among the four cores that sample this succession in the St. Louis Metro East area, core MNK-3 (38.64EN, 90.01EW) was selected for detailed study. Three sources are distinguished by the following characteristics: (1) gray smectite-quartz-Se-rich, feldspar-poor material of the Des Moines, Wadena, and James lobes; (2) reddish brown kaolinite-Cu-Fe-rich sediment of the Superior and Rainy lobes; and (3) brown illite-dolomite-Sr-rich sediment of the Lake Michigan and Green Bay lobes. The earliest sediments (44,150 to 41,700 14C yr B.P.) were derived from the central and western provenances and are chronocorrelative with the lower Roxana Silt. A hiatus occurred from about 41,700 to 29,030 14C yr B.P. when much of the middle Roxana Silt (Meadow Member) was deposited on adjacent uplands. The youngest sediment includes evidence of heightened activity of the Superior Lobe at about 29,000 14C yr B.P., the Lake Michigan and Green Bay lobes from about 25,000 to 24,000 14C yr B.P., and the Wadena-Des Moines-James lobes at about 21,000 14C yr B.P. ?? 2005 Society. Published by University of Washington. All rights reserved.

Depositional history of Louisiana-Mississippi outer continental shelf

USGS Publications Warehouse

Kindinger, J.L.; Miller, R.J.; Stelting, C.E.

1982-01-01

A geological study was undertaken in 1981 in the Louisiana-Mississippi outer continental shelf for the Bureau of Land Management. The study included a high-resolution seismic reflection survey, surficial sediment sampling and surface current drifter sampling. Approximately 7100 sq km of the Louisiana-Mississippi shelf and upper slope were surveyed. The sea floor of the entire area is relatively smooth except for occasional areas of uplift produced by diapiric intrusion along the upper slope. Characteristics of the topography and subsurface shelf sediments are the result of depositional sequences due to delta outbuilding over transgressive sediments with intervening periods of erosion during low sea level stands. Little evidence of structural deformation such as faults, diapirs, and shallow gas is present on the shelf and only a few minor faults and scarps are found on the slope. Minisparker seismic records in combination with air gun (40 and 5 cu in) and 3.5-kHz subbottom profile records reveal that seven major stages of shelf development have occurred since the middle Pleistocene. The shelf development has been controlled by the rise and fall of sea level. These stages are defined by four major unconformities, several depositions of transgressive sediments, sequences of river channeling and progradational delta deposits. Surficial sediment sample and seismic records indicate tat the last major depositional event was the progradation of the St. Bernard Delta lobe. This delta lobe covered the northwestern and central regions. Surficial sediments in most of the study area are the product of the reworking of the San Bernard Delta lobe and previous progradations.

Upper Airway Elasticity Estimation in Pediatric Down Syndrome Sleep Apnea Patients Using Collapsible Tube Theory.

PubMed

Subramaniam, Dhananjay Radhakrishnan; Mylavarapu, Goutham; McConnell, Keith; Fleck, Robert J; Shott, Sally R; Amin, Raouf S; Gutmark, Ephraim J

2016-05-01

Elasticity of the soft tissues surrounding the upper airway lumen is one of the important factors contributing to upper airway disorders such as snoring and obstructive sleep apnea. The objective of this study is to calculate patient specific elasticity of the pharynx from magnetic resonance (MR) images using a 'tube law', i.e., the relationship between airway cross-sectional area and transmural pressure difference. MR imaging was performed under anesthesia in children with Down syndrome (DS) and obstructive sleep apnea (OSA). An airway segmentation algorithm was employed to evaluate changes in airway cross-sectional area dilated by continuous positive airway pressure (CPAP). A pressure-area relation was used to make localized estimates of airway wall stiffness for each patient. Optimized values of patient specific Young's modulus for tissue in the velopharynx and oropharynx, were estimated from finite element simulations of airway collapse. Patient specific deformation of the airway wall under CPAP was found to exhibit either a non-linear 'hardening' or 'softening' behavior. The localized airway and tissue elasticity were found to increase with increasing severity of OSA. Elasticity based patient phenotyping can potentially assist clinicians in decision making on CPAP and airway or tissue elasticity can supplement well-known clinical measures of OSA severity.

The search for failed supernovae with the Large Binocular Telescope: constraints from 7 yr of data

NASA Astrophysics Data System (ADS)

Adams, S. M.; Kochanek, C. S.; Gerke, J. R.; Stanek, K. Z.

2017-08-01

We report updated results for the first 7 yr of our programme to monitor 27 galaxies within 10 Mpc using the Large Binocular Telescope to search for failed supernovae (SNe) - core collapses of massive stars that form black holes without luminous SNe. In the new data, we identify no new compelling candidates and confirm the existing candidate. Given the six successful core-collapse SNe in the sample and one likely failed SN, the implied fraction of core collapses that result in failed SNe is f=0.14^{+0.33}_{-0.10} at 90 per cent confidence. If the current candidate is a failed SN, the fraction of failed SN naturally explains the missing high-mass red supergiants SN progenitors and the black hole mass function. If the current candidate is ultimately rejected, the data imply a 90 per cent confidence upper limit on the failed SN fraction of f < 0.35.

Depositional patterns of the Mississippi Fan surface: Evidence from GLORIA II and high-resolution seismic profiles

USGS Publications Warehouse

Twichell, David C.; Kenyon, Neil H.; Parson, Lindsay M.; McGregor, Bonnie A.

1991-01-01

GLORIA long-range side-scan sonar imagery and 3.5-kHz seismic-reflection profiles depict a series of nine elongate deposits with generally high-backscatter surfaces covering most of the latest fanlobe sequence of the Mississippi Fan in the eastern Gulf of Mexico. The youngest deposit is a “slump” that covers a 250 by 100 km area of the middle and upper fan. The remaining mapped deposits, termed depositional lobes, are long (as much as 200 km) and relatively thin (less than 35 m thick) bodies. Small channels and lineations on the surface of many of these depositional lobes radiate from a single, larger main channel that is the conduit through which sediment has been supplied to these surficial deposits on the fan. The 3.5-kHz profiles show that adjacent depositional lobes overlap one another rather than interfingering, indicating that only one lobe was an active site of deposition at a time. Shifting of the depositional sites appears to be caused by both aggradation and avulsion. The chronology developed from the overlapping relations indicates the oldest of the mapped depositional lobes are on the lowermost fan, and the youngest are further up the fan. Depositional lobes on the lower fan consist of a series of smaller, elongate features with high-backscatter surfaces (540 km in length) located at the ends of previously unrecognized small channels (< 5 m deep). These small channels extend as much as 120 km from the main channel. Small channelized turbidity currents and/or debris flows, sand flows, or mud flows appear to be the dominant transport process constructing these depositional lobes. Channelized flow is an important mechanism for transporting sediment away from the main channel on this fan and the resulting facies created by these small flows are laterally discontinuous.

Detailed anatomy of a deep-water carbonate breccia lobe (Upper Jurassic, French subalpine basin)

NASA Astrophysics Data System (ADS)

Courjault, Thomas; Grosheny, Danièle; Ferry, Serge; Sausse, Judith

2011-06-01

Detailed correlations across Tithonian carbonate breccia deposits in the Drôme River area (northern part of the so-called "Vocontian Through") suggest the depositional system was that of an elongated deep-water lobe, up to 70 km long and 20 to 30 km wide, for a thickness reaching 200 m. The Drôme lobe, as it is now called, is mainly made of slope to basinal mudstones breccias with minor platform components, interpreted as debris flow and mud flow deposits, associated with slump deposits. It is basically a base-of-slope system, whose elongated depositional area implies it was a "point-sourced" gravity system, thus perhaps connected to a small canyon cut onto the western slope of the basin. But the mostly mudstone material of the breccias also suggests that the walls of this inferred canyon were the main supplier of the lobe, not the carbonate platform proper. The updip part of the lobe has a complex internal geometry as the deposition of breccia bed packages is interrupted by scourings locally 50 m-deep, indicating maybe a canyon mouth environment. The middle part of the lobe is dominated by pure vertical aggradation of breccia beds with minor intervening erosion. In the downdip part of the system a morphological compensation mechanism occurs as breccia beds tend to spread laterally. A huge slump carrying large mudstone olistoliths ends the breccia deposition at the beginning of the Berriasian. This megaslump deposit was mostly emplaced on the right side of the breccia lobe supporting the idea of a depositional relief. Our observations thus show that previous interpretations as a submarine canyon infilling or as shallow-water breccias formed in-situ by cyclic loading under attenuating hurricane waves approaching the platform are not consistent with our observations. The internal geometry of the system studied brings new data about a poorly-studied kind of "turbidite" systems that of deep-water carbonate breccias.

The role of viscosity in TATB hot spot ignition

NASA Astrophysics Data System (ADS)

Fried, Laurence E.; Zepeda-Ruis, Luis; Howard, W. Michael; Najjar, Fady; Reaugh, John E.

2012-03-01

The role of dissipative effects, such as viscosity, in the ignition of high explosive pores is investigated using a coupled chemical, thermal, and hydrodynamic model. Chemical reactions are tracked with the Cheetah thermochemical code coupled to the ALE3D hydrodynamic code. We perform molecular dynamics simulations to determine the viscosity of liquid TATB. We also analyze shock wave experiments to obtain an estimate for the shock viscosity of TATB. Using the lower bound liquid-like viscosities, we find that the pore collapse is hydrodynamic in nature. Using the upper bound viscosity from shock wave experiments, we find that the pore collapse is closest to the viscous limit.

In silico investigation of blast-induced intracranial fluid cavitation as it potentially leads to traumatic brain injury

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haniff, S.; Taylor, P. A.

In this paper, we conducted computational macroscale simulations predicting blast-induced intracranial fluid cavitation possibly leading to brain injury. To further understanding of this problem, we developed microscale models investigating the effects of blast-induced cavitation bubble collapse within white matter axonal fiber bundles of the brain. We model fiber tracks of myelinated axons whose diameters are statistically representative of white matter. Nodes of Ranvier are modeled as unmyelinated sections of axon. Extracellular matrix envelops the axon fiber bundle, and gray matter is placed adjacent to the bundle. Cavitation bubbles are initially placed assuming an intracranial wave has already produced them. Pressuremore » pulses, of varied strengths, are applied to the upper boundary of the gray matter and propagate through the model, inducing bubble collapse. Simulations, conducted using the shock wave physics code CTH, predict an increase in pressure and von Mises stress in axons downstream of the bubbles after collapse. This appears to be the result of hydrodynamic jetting produced during bubble collapse. Interestingly, results predict axon cores suffer significantly lower shear stresses from proximal bubble collapse than does their myelin sheathing. Finally, simulations also predict damage to myelin sheathing, which, if true, degrades axonal electrical transmissibility and general health of the white matter structures in the brain.« less

Aerogeophysical measurements of collapse-prone hydrothermally altered zones at Mount Rainier volcano.

PubMed

Finn, C A; Sisson, T W; Deszcz-Pan, M

2001-02-01

Hydrothermally altered rocks can weaken volcanoes, increasing the potential for catastrophic sector collapses that can lead to destructive debris flows. Evaluating the hazards associated with such alteration is difficult because alteration has been mapped on few active volcanoes and the distribution and severity of subsurface alteration is largely unknown on any active volcano. At Mount Rainier volcano (Washington, USA), collapses of hydrothermally altered edifice flanks have generated numerous extensive debris flows and future collapses could threaten areas that are now densely populated. Preliminary geological mapping and remote-sensing data indicated that exposed alteration is contained in a dyke-controlled belt trending east-west that passes through the volcano's summit. But here we present helicopter-borne electromagnetic and magnetic data, combined with detailed geological mapping, to show that appreciable thicknesses of mostly buried hydrothermally altered rock lie mainly in the upper west flank of Mount Rainier. We identify this as the likely source for future large debris flows. But as negligible amounts of highly altered rock lie in the volcano's core, this might impede collapse retrogression and so limit the volumes and inundation areas of future debris flows. Our results demonstrate that high-resolution geophysical and geological observations can yield unprecedented views of the three-dimensional distribution of altered rock.

In silico investigation of blast-induced intracranial fluid cavitation as it potentially leads to traumatic brain injury

DOE PAGES

Haniff, S.; Taylor, P. A.

2017-10-17

In this paper, we conducted computational macroscale simulations predicting blast-induced intracranial fluid cavitation possibly leading to brain injury. To further understanding of this problem, we developed microscale models investigating the effects of blast-induced cavitation bubble collapse within white matter axonal fiber bundles of the brain. We model fiber tracks of myelinated axons whose diameters are statistically representative of white matter. Nodes of Ranvier are modeled as unmyelinated sections of axon. Extracellular matrix envelops the axon fiber bundle, and gray matter is placed adjacent to the bundle. Cavitation bubbles are initially placed assuming an intracranial wave has already produced them. Pressuremore » pulses, of varied strengths, are applied to the upper boundary of the gray matter and propagate through the model, inducing bubble collapse. Simulations, conducted using the shock wave physics code CTH, predict an increase in pressure and von Mises stress in axons downstream of the bubbles after collapse. This appears to be the result of hydrodynamic jetting produced during bubble collapse. Interestingly, results predict axon cores suffer significantly lower shear stresses from proximal bubble collapse than does their myelin sheathing. Finally, simulations also predict damage to myelin sheathing, which, if true, degrades axonal electrical transmissibility and general health of the white matter structures in the brain.« less

Aerogeophysical measurements of collapse-prone hydrothermally altered zones at Mount Rainier volcano

USGS Publications Warehouse

Finn, C.A.; Sisson, T.W.; Deszcz-Pan, M.

2001-01-01

Hydrothermally altered rocks can weaken volcanoes, increasing the potential for catastrophic sector collapses that can lead to destructive debris flows1. Evaluating the hazards associated with such alteration is difficult because alteration has been mapped on few active volcanoes1-4 and the distribution and severity of subsurface alteration is largely unknown on any active volcano. At Mount Rainier volcano (Washington, USA), collapses of hydrothermally altered edifice flanks have generated numerous extensive debris flows5,6 and future collapses could threaten areas that are now densely populated7. Preliminary geological mapping and remote-sensing data indicated that exposed alteration is contained in a dyke-controlled belt trending east-west that passes through the volcano's summit3-5,8. But here we present helicopter-borne electromagnetic and magnetic data, combined with detailed geological mapping, to show that appreciable thicknesses of mostly buried hydrothermally altered rock lie mainly in the upper west flank of Mount Rainier. We identify this as the likely source for future large debris flows. But as negligible amounts of highly altered rock lie in the volcano's core, this might impede collapse retrogression and so limit the volumes and inundation areas of future debris flows. Our results demonstrate that high-resolution geophysical and geological observations can yield unprecedented views of the three-dimensional distribution of altered rock.

In silico investigation of blast-induced intracranial fluid cavitation as it potentially leads to traumatic brain injury

NASA Astrophysics Data System (ADS)

Haniff, S.; Taylor, P. A.

2017-11-01

We conducted computational macroscale simulations predicting blast-induced intracranial fluid cavitation possibly leading to brain injury. To further understanding of this problem, we developed microscale models investigating the effects of blast-induced cavitation bubble collapse within white matter axonal fiber bundles of the brain. We model fiber tracks of myelinated axons whose diameters are statistically representative of white matter. Nodes of Ranvier are modeled as unmyelinated sections of axon. Extracellular matrix envelops the axon fiber bundle, and gray matter is placed adjacent to the bundle. Cavitation bubbles are initially placed assuming an intracranial wave has already produced them. Pressure pulses, of varied strengths, are applied to the upper boundary of the gray matter and propagate through the model, inducing bubble collapse. Simulations, conducted using the shock wave physics code CTH, predict an increase in pressure and von Mises stress in axons downstream of the bubbles after collapse. This appears to be the result of hydrodynamic jetting produced during bubble collapse. Interestingly, results predict axon cores suffer significantly lower shear stresses from proximal bubble collapse than does their myelin sheathing. Simulations also predict damage to myelin sheathing, which, if true, degrades axonal electrical transmissibility and general health of the white matter structures in the brain.

Gravity or turbulence? IV. Collapsing cores in out-of-virial disguise

NASA Astrophysics Data System (ADS)

Ballesteros-Paredes, Javier; Vázquez-Semadeni, Enrique; Palau, Aina; Klessen, Ralf S.

2018-06-01

We study the dynamical state of massive cores by using a simple analytical model, an observational sample, and numerical simulations of collapsing massive cores. From the analytical model, we find that cores increase their column density and velocity dispersion as they collapse, resulting in a time evolution path in the Larson velocity dispersion-size diagram from large sizes and small velocity dispersions to small sizes and large velocity dispersions, while they tend to equipartition between gravity and kinetic energy. From the observational sample, we find that: (a) cores with substantially different column densities in the sample do not follow a Larson-like linewidth-size relation. Instead, cores with higher column densities tend to be located in the upper-left corner of the Larson velocity dispersion σv, 3D-size R diagram, a result explained in the hierarchical and chaotic collapse scenario. (b) Cores appear to have overvirial values. Finally, our numerical simulations reproduce the behavior predicted by the analytical model and depicted in the observational sample: collapsing cores evolve towards larger velocity dispersions and smaller sizes as they collapse and increase their column density. More importantly, however, they exhibit overvirial states. This apparent excess is due to the assumption that the gravitational energy is given by the energy of an isolated homogeneous sphere. However, such excess disappears when the gravitational energy is correctly calculated from the actual spatial mass distribution. We conclude that the observed energy budget of cores is consistent with their non-thermal motions being driven by their self-gravity and in the process of dynamical collapse.

Characteristics, extent and origin of hydrothermal alteration at Mount Rainier Volcano, Cascades Arc, USA: Implications for debris-flow hazards and mineral deposits

NASA Astrophysics Data System (ADS)

John, David A.; Sisson, Thomas W.; Breit, George N.; Rye, Robert O.; Vallance, James W.

2008-08-01

Hydrothermal alteration at Mount Rainier waxed and waned over the 500,000-year episodic growth of the edifice. Hydrothermal minerals and their stable-isotope compositions in samples collected from outcrop and as clasts from Holocene debris-flow deposits identify three distinct hypogene argillic/advanced argillic hydrothermal environments: magmatic-hydrothermal, steam-heated, and magmatic steam (fumarolic), with minor superimposed supergene alteration. The 3.8 km 3 Osceola Mudflow (5600 y BP) and coeval phreatomagmatic F tephra contain the highest temperature and most deeply formed hydrothermal minerals. Relatively deeply formed magmatic-hydrothermal alteration minerals and associations in clasts include quartz (residual silica), quartz-alunite, quartz-topaz, quartz-pyrophyllite, quartz-dickite/kaolinite, and quartz-illite (all with pyrite). Clasts of smectite-pyrite and steam-heated opal-alunite-kaolinite are also common in the Osceola Mudflow. In contrast, the Paradise lahar, formed by collapse of the summit or near-summit of the edifice at about the same time, contains only smectite-pyrite and near-surface steam-heated and fumarolic alteration minerals. Younger debris-flow deposits on the west side of the volcano (Round Pass and distal Electron Mudflows) contain only low-temperature smectite-pyrite assemblages, whereas the proximal Electron Mudflow and a < 100 y BP rock avalanche on Tahoma Glacier also contain magmatic-hydrothermal alteration minerals that are exposed in the avalanche headwall of Sunset Amphitheater, reflecting progressive incision into deeper near-conduit alteration products that formed at higher temperatures. The pre-Osceola Mudflow alteration geometry is inferred to have consisted of a narrow feeder zone of intense magmatic-hydrothermal alteration limited to near the conduit of the volcano, which graded outward to more widely distributed, but weak, smectite-pyrite alteration within 1 km of the edifice axis, developed chiefly in porous breccias. The edifice was capped by a steam-heated alteration zone, most of which resulted from condensation of fumarolic vapor and oxidation of H 2S in the unsaturated zone above the water table. Weakly developed smectite-pyrite alteration extended into the west and east flanks of the edifice, spatially associated with dikes that are localized in those sectors; other edifice flanks lack dikes and associated alteration. The Osceola collapse removed most of the altered core and upper east flank of the volcano, but intensely altered rocks remain on the uppermost west flank. Major conclusions of this study are that: (1) Hydrothermal-mineral assemblages and distributions at Mount Rainier can be understood in the framework of hydrothermal processes and environments developed from studies of ore deposits formed in analogous settings. (2) Frequent eruptions supplied sufficient hot magmatic fluid to alter the upper interior of the volcano hydrothermally, despite the consistently deep (≥ 8 km) magma reservoir which may have precluded formation of economic mineral deposits within or at shallow depths beneath Mount Rainier. The absence of indicator equilibrium alteration-mineral assemblages in the debris flows that effectively expose the volcano to a depth of 1-1.5 km also suggests a low potential for significant high-sulfidation epithermal or porphyry-type mineral deposits at depth. (3) Despite the long and complex history of the volcano, intensely altered collapse-prone rocks were spatially restricted to near the volcano's conduit system and summit, and short distances onto the upper east and west flanks, due to the necessary supply of reactive components carried by ascending magmatic fluids. (4) Intensely altered rocks were removed from the summit, east flank, and edifice interior by the Osceola collapse, but remain on the upper west flank in the Sunset Amphitheater area and present a continuing collapse hazard. (5) Visually conspicuous rocks on the lower east and mid-to-lower west flanks are not intensely altered and probably have not significantly weakened the rock, and thus do not present significant collapse hazards. (6) Alteration developed most intensely within breccia units, because of their high permeability and porosity. Volcanoes with abundant near-conduit upper-edifice breccias are prone to alteration increasing the possibility of collapse, whereas those that are breccia-poor (e.g., massive domes) are less prone to alteration.

Effects of tillage and poultry manure application rates on Salmonella and fecal indicator bacteria concentrations in tiles draining Des Moines Lobe soils

USDA-ARS?s Scientific Manuscript database

Application of poultry manure (PM) to cropland as fertilizer is a common practice in artificially drained regions of the Upper Midwest. To assess the potential for PM to contribute pathogenic bacteria to downstream waters, information is needed on the impacts of manure management and tillage practi...

Cardiovascular risk and mortality in end-stage renal disease patients undergoing dialysis: sleep study, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life: a prospective, double blind, randomized controlled clinical trial.

PubMed

dos Reis Santos, Israel; Danaga, Aline Roberta; de Carvalho Aguiar, Isabella; Oliveira, Ezequiel Fernandes; Dias, Ismael Souza; Urbano, Jessica Julioti; Martins, Aline Almeida; Ferraz, Leonardo Macario; Fonsêca, Nina Teixeira; Fernandes, Virgilio; Fernandes, Vinicius Alves Thomaz; Lopes, Viviane Cristina Delgado; Leitão Filho, Fernando Sérgio Studart; Nacif, Sérgio Roberto; de Carvalho, Paulo de Tarso Camillo; Sampaio, Luciana Maria Malosá; Giannasi, Lílian Christiane; Romano, Salvatore; Insalaco, Giuseppe; Araujo, Ana Karina Fachini; Dellê, Humberto; Souza, Nadia Karina Guimarães; Giannella-Neto, Daniel; Oliveira, Luis Vicente Franco

2013-10-08

Chronic kidney disease (CKD) is one of the most serious public health problems. The increasing prevalence of CKD in developed and developing countries has led to a global epidemic. The hypothesis proposed is that patients undergoing dialysis would experience a marked negative influence on physiological variables of sleep and autonomic nervous system activity, compromising quality of life. A prospective, consecutive, double blind, randomized controlled clinical trial is proposed to address the effect of dialysis on sleep, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life in patients with CKD. The measurement protocol will include body weight (kg); height (cm); body mass index calculated as weight/height(2); circumferences (cm) of the neck, waist, and hip; heart and respiratory rates; blood pressures; Mallampati index; tonsil index; heart rate variability; maximum ventilatory pressures; negative expiratory pressure test, and polysomnography (sleep study), as well as the administration of specific questionnaires addressing sleep apnea, excessive daytime sleepiness, depression, anxiety, stress, and quality of life. CKD is a major public health problem worldwide, and its incidence has increased in part by the increased life expectancy and increasing number of cases of diabetes mellitus and hypertension. Sleep disorders are common in patients with renal insufficiency. Our hypothesis is that the weather weight gain due to volume overload observed during interdialytic period will influence the degree of collapsibility of the upper airway due to narrowing and predispose to upper airway occlusion during sleep, and to investigate the negative influences of haemodialysis in the physiological variables of sleep, and autonomic nervous system, and respiratory mechanics and thereby compromise the quality of life of patients. The protocol for this study is registered with the Brazilian Registry of Clinical Trials (ReBEC RBR-7yhr4w and World Health Organization under Universal Trial Number UTN: U1111-1127-9390 [http://www.ensaiosclinicos.gov.br/rg/RBR-7yhr4w/]).

Patient with Small Cell Lung Carcinoma and Suspected Right Upper Lobe Abscess Presenting with a Purulent Pericardial Effusion.

PubMed

Goel, Khushboo; Ateeli, Huthayfa; Ampel, Neil M; L'heureux, Dena

2016-07-22

BACKGROUND Cardiac tamponade caused by pericardial effusion has a high mortality rate; thus, it is important to diagnose and treat this condition immediately. Specifically, bacterial pericarditis, although now very rare, is often fatal because of its fulminant process. CASE REPORT We present a case of a 61-year-old man with metastatic small cell lung cancer undergoing chemotherapy who presented with fatigue, poor appetite, and altered mental status. He was found to have a large-volume pericardial effusion with tamponade physiology. He underwent emergent pericardiocentesis. The pericardial effusion was nonmalignant, with cultures growing Streptococcus pneumoniae. It was only after his emergent pericardiocentesis that previous imaging from one month prior was able to be reviewed, which showed possible right upper lobe abscess. CONCLUSIONS Most pericardial effusions in cancer patients are related to their malignancy, either due to direct metastasis or secondary physiologic effects. This case is a unique example of a lung cancer patient presenting with a pneumococcal pericardial effusion, which in itself is a rare phenomenon. This case report demonstrates the importance of considering early antibiotic therapy in patients presenting with pericardial effusion, especially given the high mortality rates of infectious pericardial effusions.

Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects.

PubMed

Dominguez, Mariana Chiaradia; Alvares, Beatriz Regina

2018-01-01

To analyze the radiological aspects of pulmonary atelectasis in newborns on mechanical ventilation and treated in an intensive care unit, associating the characteristics of atelectasis with the positioning of the head and endotracheal tube seen on the chest X-ray, as well as with the clinical variables. This was a retrospective cross-sectional study of 60 newborns treated between 1985 and 2015. Data were collected from medical records and radiology reports. To identify associations between variables, we used Fisher's exact test. The level of significance was set at p < 0.05. The clinical characteristics associated with improper positioning of the endotracheal tube were prematurity and a birth weight of less than 1000 g. Among the newborns evaluated, the most common comorbidity was hyaline membrane disease. Atelectasis was seen most frequently in the right upper lobe, although cases of total atelectasis were more common in the left lung. Malpositioning of the head showed a trend toward an association with atelectasis in the left upper lobe. Pulmonary atelectasis is a common complication in newborns on mechanical ventilation. Radiological evaluation of the endotracheal tube placement provides relevant information for the early correction of this condition.

Upper triassic continental margin strata of the central alaska range: Implications for paleogeographic reconstruction

USGS Publications Warehouse

Till, A.B.; Harris, A.G.; Wardlaw, B.R.; Mullen, M.

2007-01-01

Reexamination of existing conodont collections from the central Alaska Range indicates that Upper Triassic marine slope and basin rocks range in age from at least as old as the late Carnian to the early middle Norian. The conodont assemblages typical of these rocks are generally cosmopolitan and do not define a distinct paleogeographic faunal realm. One collection, however, containsEpigondolella multidentata sensu Orchard 1991c, which appears to be restricted to western North American autochthonous rocks. Although paleogeographic relations cannot be determined with specificity, the present distribution of biofaces within the Upper Triassic sequence could not have been the result of simple accordion-style collapse of the Late Triassic margin.

Piercing the upper ear: a simple infection, a difficult reconstruction.

PubMed

Cicchetti, S; Skillman, J; Gault, D T

2002-04-01

Piercing the upper ear to retain jewellery is now commonplace. When infection ensues, devastating chondritis leads to collapse of the ear. To our knowledge, the surgical reconstruction of post-piercing deformities has not been documented in the literature. We present five such cases referred for autogenous-tissue ear reconstruction. In four of these, the destroyed segments of ear cartilage were replaced with a carved costal-cartilage framework. One patient declined surgery. The importance of preventing infection is stressed. Copyright 2002 The British Association of Plastic Surgeons.

Control of early-formed vesicle cylinders on upper crustal prismatic jointing in compound pāhoehoe lavas of Elephanta Island, western Deccan Traps, India

NASA Astrophysics Data System (ADS)

Sheth, Hetu; Patel, Vanit; Samant, Hrishikesh

2017-08-01

Upper crustal prismatic joints and vesicle cylinders, common in pāhoehoe lava flows, form early and late, respectively, and are therefore independent features. However, small-scale compound pāhoehoe lava lobes on Elephanta Island (western Deccan Traps, India), which resemble S-type (spongy) pāhoehoe in some aspects, contain vesicle cylinders which apparently controlled the locations of upper crustal prismatic joints. The lobes are decimeters thick, did not experience inflation after emplacement, and solidified rapidly. They have meter-scale areas that are exceptionally rich in vesicle cylinders (up to 68 cylinders in 1 m2, with a mean spacing of 12.1 cm), separated by cylinder-free areas, and pervasive upper crustal prismatic jointing with T, curved T, and quadruple joint intersections. A majority (≥76.5%) of the cylinders are located exactly on joints or at joint intersections, and were not simply captured by downward growing joints, as the cylinders show no deflection in vertical section. We suggest that large numbers of cylinders originated in a layer of bubble-rich residual liquid at the top of a basal diktytaxitic crystal mush zone which was formed very early (probably within the first few minutes of the emplacement history). The locations where the rising cylinders breached the crust provided weak points or mechanical flaws towards which any existing joints (formed by thermal contraction) propagated. New joints may also have propagated outwards from the cylinders and linked up laterally. Some cylinders breached the crust between the joints, and thus formed a little later than most others. The Elephanta Island example reveals that, whereas thermal contraction is undoubtedly valid as a standard mechanism for forming upper crustal prismatic joints, abundant mechanical flaws (such as large concentrations of early-formed, crust-breaching vesicle cylinders) can also control the joint formation process.

Resonant Tidal Forcing in Close Binaries: Implications for CVs

NASA Astrophysics Data System (ADS)

Ford, K. E. Saavik; McKernan, Barry; Schwab, Elliana

2018-01-01

Resonant tidal forcing occurs when the tidal forcing frequency of a binary matches a quadrupolar oscillation mode of one of the binary members and energy is transferred from the orbit of the binary to the mode. Tidal locking permits ongoing resonant driving of modes even as binary orbital parameters change. At small binary separations during tidal lock, a significant fraction of binary orbital energy can be deposited quickly into a resonant mode and the binary decays faster than via the emission of gravitational radiation alone. Here we discuss some of the implications of resonant tidal forcing for the class of binaries known as Cataclysmic Variable (CV) stars. We show that resonant tidal forcing of the donor’s Roche lobe could explain the observed 2‑3hr period gap in CVs, assuming modest orbital eccentricities are allowed (eb ∼ 0.03), and can be complementary or an alternative to, existing models. Sudden collapse of the companion orbit, yielding a Type Ia supernova is disfavoured, since Hydrogen is not observed in Type Ia supernova spectra. Therefore, resonance must generally be truncated, probably via mass loss from the Roche lobe or orbital perturbation, ultimately producing a short period CV containing an ’overheated’ white dwarf.

Marsh collapse thresholds for coastal Louisiana estimated using elevation and vegetation index data

USGS Publications Warehouse

Couvillion, Brady R.; Beck, Holly

2013-01-01

Forecasting marsh collapse in coastal Louisiana as a result of changes in sea-level rise, subsidence, and accretion deficits necessitates an understanding of thresholds beyond which inundation stress impedes marsh survival. The variability in thresholds at which different marsh types cease to occur (i.e., marsh collapse) is not well understood. We utilized remotely sensed imagery, field data, and elevation data to help gain insight into the relationships between vegetation health and inundation. A Normalized Difference Vegetation Index (NDVI) dataset was calculated using remotely sensed data at peak biomass (August) and used as a proxy for vegetation health and productivity. Statistics were calculated for NDVI values by marsh type for intermediate, brackish, and saline marsh in coastal Louisiana. Marsh-type specific NDVI values of 1.5 and 2 standard deviations below the mean were used as upper and lower limits to identify conditions indicative of collapse. As marshes seldom occur beyond these values, they are believed to represent a range within which marsh collapse is likely to occur. Inundation depth was selected as the primary candidate for evaluation of marsh collapse thresholds. Elevation relative to mean water level (MWL) was calculated by subtracting MWL from an elevation dataset compiled from multiple data types including light detection and ranging (lidar) and bathymetry. A polynomial cubic regression was used to examine a random subset of pixels to determine the relationship between elevation (relative to MWL) and NDVI. The marsh collapse uncertainty range values were found by locating the intercept of the regression line with the 1.5 and 2 standard deviations below the mean NDVI value for each marsh type. Results indicate marsh collapse uncertainty ranges of 30.7–35.8 cm below MWL for intermediate marsh, 20–25.6 cm below MWL for brackish marsh, and 16.9–23.5 cm below MWL for saline marsh. These values are thought to represent the ranges of inundation depths within which marsh collapse is probable.

Fishing amplifies forage fish population collapses.

PubMed

Essington, Timothy E; Moriarty, Pamela E; Froehlich, Halley E; Hodgson, Emma E; Koehn, Laura E; Oken, Kiva L; Siple, Margaret C; Stawitz, Christine C

2015-05-26

Forage fish support the largest fisheries in the world but also play key roles in marine food webs by transferring energy from plankton to upper trophic-level predators, such as large fish, seabirds, and marine mammals. Fishing can, thereby, have far reaching consequences on marine food webs unless safeguards are in place to avoid depleting forage fish to dangerously low levels, where dependent predators are most vulnerable. However, disentangling the contributions of fishing vs. natural processes on population dynamics has been difficult because of the sensitivity of these stocks to environmental conditions. Here, we overcome this difficulty by collating population time series for forage fish populations that account for nearly two-thirds of global catch of forage fish to identify the fingerprint of fisheries on their population dynamics. Forage fish population collapses shared a set of common and unique characteristics: high fishing pressure for several years before collapse, a sharp drop in natural population productivity, and a lagged response to reduce fishing pressure. Lagged response to natural productivity declines can sharply amplify the magnitude of naturally occurring population fluctuations. Finally, we show that the magnitude and frequency of collapses are greater than expected from natural productivity characteristics and therefore, likely attributed to fishing. The durations of collapses, however, were not different from those expected based on natural productivity shifts. A risk-based management scheme that reduces fishing when populations become scarce would protect forage fish and their predators from collapse with little effect on long-term average catches.

Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes.

PubMed

Come, Carolyn E; Diaz, Alejandro A; Curran-Everett, Douglas; Muralidhar, Nivedita; Hersh, Craig P; Zach, Jordan A; Schroeder, Joyce; Lynch, David A; Celli, Bartolome; Washko, George R

2013-06-01

CT scanning is increasingly used to characterize COPD. Although it is possible to obtain CT scan-measured lung lobe volumes, normal ranges remain unknown. Using COPDGene data, we developed reference equations for lobar volumes at maximal inflation (total lung capacity [TLC]) and relaxed exhalation (approximating functional residual capacity [FRC]). Linear regression was used to develop race-specific (non-Hispanic white [NHW], African American) reference equations for lobar volumes. Covariates included height and sex. Models were developed in a derivation cohort of 469 subjects with normal pulmonary function and validated in 546 similar subjects. These cohorts were combined to produce final prediction equations, which were applied to 2,191 subjects with old GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage II to IV COPD. In the derivation cohort, women had smaller lobar volumes than men. Height positively correlated with lobar volumes. Adjusting for height, NHWs had larger total lung and lobar volumes at TLC than African Americans; at FRC, NHWs only had larger lower lobes. Age and weight had no effect on lobar volumes at TLC but had small effects at FRC. In subjects with COPD at TLC, upper lobes exceeded 100% of predicted values in GOLD II disease; lower lobes were only inflated to this degree in subjects with GOLD IV disease. At FRC, gas trapping was severe irrespective of disease severity and appeared uniform across the lobes. Reference equations for lobar volumes may be useful in assessing regional lung dysfunction and how it changes in response to pharmacologic therapies and surgical or endoscopic lung volume reduction.

Impact of endobronchial coiling on segmental bronchial lumen in treated and untreated lung lobes: Correlation with changes in lung volume, clinical and pulmonary function tests.

PubMed

Kloth, C; Thaiss, W M; Hetzel, J; Ditt, H; Grosse, U; Nikolaou, K; Horger, M

2016-07-01

To assess the impact of endobronchial coiling on the segment bronchus cross-sectional area and volumes in patients with lung emphysema using quantitative chest-CT measurements. Thirty patients (female = 15; median age = 65.36 years) received chest-CT before and after endobronchial coiling for lung volume reduction (LVR) between January 2010 and December 2014. Thin-slice (0.6 mm) non-enhanced image data sets were acquired both at end-inspiration and end-expiration using helical technique and 120 kV/100-150 mAs. Clinical response was defined as an increase in the walking distance (Six-minute walk test; 6MWT) after LVR-therapy. Additionally, pulmonary function test (PFT) measurements were used for clinical correlation. In the treated segmental bronchia, the cross-sectional lumen area showed significant reduction (p < 0.05) in inspiration and tendency towards enlargement in expiration (p > 0.05). In the ipsilateral lobes, the lumina showed no significant changes. In the contralateral lung, we found tendency towards increased cross-sectional area in inspiration (p = 0.06). Volumes of the treated segments correlated with the treated segmental bronchial lumina in expiration (r = 0.80, p < 0.001). Clinical correlation with changes in 6MWT/PFT showed a significant decrease of the inspiratory volume of the treated lobe in responders only. Endobronchial coiling causes significant decrease in the cross-sectional area of treated segment bronchi in inspiration and a slight increase in expiration accompanied by a volume reduction. • Endobronchial coiling has indirect impact on cross-sectional area of treated segment bronchi • Volume changes of treated lobes correlate with changes in bronchial cross-sectional area • Coil-induced effects reflect their stabilizing and stiffening impact on lung parenchyma • Endobronchial coiling reduces bronchial collapsing compensating the loss of elasticity.

Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury

DTIC Science & Technology

2013-10-01

requiring pacemaker  Refusal of consent - Claustrophobia  Spinal Cord Injury  Unstable due to tracheal stenosis and lobar collapse  2 patients had...be stopped.  Heart Block necessitating pacemaker  Unstable from a respiratory point of view due to previous Left lower lobectomy, right upper

4. LOWER NOTTINGHAM MINE. DETAIL OF OBJECTS ASSOCIATED WITH CABIN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. LOWER NOTTINGHAM MINE. DETAIL OF OBJECTS ASSOCIATED WITH CABIN 'B'; PIPE, WOOD, STOVE MATERIALS, AND COLLAPSED ROOT CELLAR IN CENTRAL AREA. VERTICAL, DARK PIPE IS VISIBLE IN CENTER/UPPER THIRD. CAMERA POINTED EAST. - Florida Mountain Mining Sites, Lower Nottingham Mine, Western slope of Florida Mountain, Silver City, Owyhee County, ID

Geologic characterization report for the Paradox Basin Study Region, Utah Study Areas. Volume 6: Salt Valley

NASA Astrophysics Data System (ADS)

1984-12-01

Surface landforms in the Salt Valley Area are generally a function of the Salt Valley anticline and are characterized by parallel and subparallel cuestaform ridges and hogbacks and flat valley floors. The most prominent structure in the Area is the Salt Valley anticline. Erosion resulting from the Tertiary uplift of the Colorado Plateau led to salt dissolution and subsequent collapse along the crest of the anticline. Continued erosion removed the collapse material, forming an axial valley along the crest of the anticline. Paleozoic rocks beneath the salt bearing Paradox Formation consist of limestone, dolomite, sandstone, siltstone and shale. The salt beds of the Paradox formation occur in distinct cycles separated by an interbed sequence of anhydrite, carbonate, and clastic rocks. The Paradox Formation is overlain by Pennsylvanian limestone; Permian sandstone; and Mesozoic sandstone, mudstone, conglomerate and shale. No earthquakes have been reported in the area during the period of the historic record and contemporary seismicity appears to be diffusely distributed, of low level and small magnitude. The upper unit includes the Permian strata and upper Honaker trail formation.

Coastline change and marine geo-hazards in the Yellow River Delta (China)

NASA Astrophysics Data System (ADS)

Zhou, L.; Liu, J.; Liu, X.

2003-04-01

COASTLINE CHANGE AND MARINE GEO-HAZARDS IN THE YELLOW RIVER DELTA (CHINA) Zhou Liangyong(1,2), Liu Jian(1,3), Liu Xiqing(1) (1)Qingdao Institute of Marine Geology,(2)Ocean University of China,(3)Research Centre for Coastal Geology, CGS qdzliangyong@cgs.gov.cn/Fax: +86-532-5720553 Satellite remote sensing, bathymetry and high-resolution seismic data have been used to examine the coastline change during the period from 1976 to 2001 and the offshore marine geo-hazards in the modern Yellow River Delta. Trends in the temporal sequence of the eight coastlines derived from Landsat images were used in the definition of erosional classes of the coastline. Four classes were distinguished, including rapid erosion (>100 m/yr), moderate erosion (20-100 m/yr), no detectable erosion (-1 - 20 m/yr), and accretion (-200--1 m/yr). We revealed the subtle variations in sea floor morphology and sediment geometries using high-resolution acoustic survey. Many kinds of geo-hazards were identified in the active subaqueous delta lobe and abandoned delta lobes, such as seabed erosions, gas-charged sediments, listric faults, synsedimentary rises, incised palaeo-valleys, infilled gullies, diapirs, active slope failures and sediment collapses. The resultant map of geo-envrionment and geo-hazards presents the coastline change and distribution of geo-hazards mentioned above in the Yellow River Delta. The gas-charged sediment distributes mainly in the abandoned delta lobes. The synsedimentary rise outside of the modern river mouth is a new evidence for the seabed mass-movement which modifies the progradational subaquaeous slopes of modern Yellow River Delta.

Reconstruction of Ancestral Hydrothermal Systems on Mount Rainier Using Hydrothermally Altered Rocks in Holocene Debris Flows and Tephras

NASA Astrophysics Data System (ADS)

John, D. A.; Breit, G. N.; Sisson, T. W.; Vallance, J. W.; Rye, R. O.

2005-12-01

Mount Rainier is the result of episodic stages of edifice growth during periods of high eruptive activity and edifice destruction during periods of relative magmatic quiescence over the past 500 kyr. Edifice destruction occurred both by slow erosion and by catastrophic collapses, some of which were strongly influenced by hydrothermal alteration. Several large-volume Holocene debris-flow deposits contain abundant clasts of hydrothermally altered rocks, most notably the 4-km3 clay-rich Osceola Mudflow which formed by collapse of the northeast side and upper 1000+ m of the edifice about 5600 ya and flowed >120 km downstream into Puget Sound. Mineral assemblages and stable isotope data of hydrothermal alteration products in Holocene debris-flow deposits indicate formation in distinct hydrothermal environments, including magmatic-hydrothermal, steam-heated (including a large fumarolic component), magmatic steam (including a possible fumarolic component), and supergene. The Osceola Mudflow and phreatic components of coeval tephras contain the highest-temperature and inferred most deeply formed alteration minerals; assemblages include magmatic-hydrothermal quartz-alunite, quartz-topaz, quartz-pyrophyllite and quartz-illite (all +pyrite), in addition to steam-heated opal-alunite-kaolinite and abundant smectite-pyrite. In contrast, the Paradise lahar, which formed by a collapse of the surficial upper south side of the edifice, contains only steam-heated assemblages including those formed largely above the water table from condensation of fumarolic vapor (opal-alunite-jarosite). Younger debris-flow deposits on the west side of the volcano (Round Pass lahar and Electron Mudflow) contain only smectite-pyrite alteration, whereas an early 20th century rock avalanche on Tahoma Glacier also contains magmatic-hydrothermal alteration that is exposed in the avalanche headwall of Sunset Amphitheater. Mineralogy and isotopic composition of the alteration phases, geologic and geophysical data, as well as analog fossil hydrothermal systems in volcanoes elsewhere, constrain hydrothermal alteration geometry on the pre-Osceola-collapse edifice of Mount Rainier. Relatively narrow zones of acid magmatic-hydrothermal alteration in the central core of the volcano grade to more widely distributed smectite-pyrite alteration farther out on the upper flanks, capped by steam-heated alteration with a large component of alteration resulting from condensation of fumarolic vapor above the water table. Alteration was polygenetic in zones formed episodically, and was strongly controlled by fluxes of heat and magmatic fluid and by local permeability.

Submarine fan facies of Upper Cretaceous Strata, Southern San Rafael Mountains, Santa Barbara County, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toyne, C.D.

1986-04-01

A 2900-m thick Campanian-Maestrichtian(.) turbidite sequence in Upper Mono Creek Canyon is interpreted to be a progradational submarine fan complex comprised of outer fan, middle fan, inner fan, and slope facies. The basal 600 m of the section consists of thinly bedded, laterally continuous fine sandstones, siltstones, and mudstones (mainly Mutti and Ricci Lucci facies D), interpreted to be outer fan interlobe and lobe-fringe deposits. These are punctuated by infrequent medium to very thickly bedded, flat-based, fine to coarse sandstones (facies C and B), which commonly coarsen and thicken upward, and are interpreted to be depositional lobes. Overlying these depositsmore » are approximately 1400 m of middle fan deposits composed of frequent lenticular, commonly channelized and amalgamated, thickly bedded, fine to very coarse sandstones (facies C and B) organized in fining- and thinning-upward sequences, interpreted to be braided-channel deposits. These alternate with less common nonchannelized coarsening- and thickening-upward sequences suggestive of lobe-apical cycles. These multistory sand deposits are nested within thick intervals of fine sandstones, siltstones, and mudstones (facies C and D), interpreted to be levee, crevasse-splay, and interchannel deposits. Interfingered with and overlying these deposits are approximately 500 m of fining- and thinning-upward or noncyclic, erosionally based, commonly amalgamated, very thickly bedded, medium to very coarse sandstones, pebbly sandstones, and conglomerates (facies A and B), interpreted to be inner fan deposits. Intercalated within this facies, infrequent, laterally discontinuous, thin to thickly bedded, fine to coarse sandstones, siltstones, and mudstones exist, interpreted to be interchannel, levee, and possibly channel-fill deposits.« less

Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.

PubMed

Kraft, Bryan D; Suliman, Hagir B; Colman, Eli C; Mahmood, Kamran; Hartwig, Matthew G; Piantadosi, Claude A; Shofer, Scott L

2016-03-01

Central airway stenosis (CAS) after lung transplantation has been attributed in part to chronic airway ischemia; however, little is known about the time course or significance of large airway hypoxia early after transplantation. To evaluate large airway oxygenation and hypoxic gene expression during the first month after lung transplantation and their relation to airway complications. Subjects who underwent lung transplantation underwent endobronchial tissue oximetry of native and donor bronchi at 0, 3, and 30 days after transplantation (n = 11) and/or endobronchial biopsies (n = 14) at 30 days for real-time polymerase chain reaction of hypoxia-inducible genes. Patients were monitored for 6 months for the development of transplant-related complications. Compared with native endobronchial tissues, donor tissue oxygen saturations (Sto2) were reduced in the upper lobes (74.1 ± 1.8% vs. 68.8 ± 1.7%; P < 0.05) and lower lobes (75.6 ± 1.6% vs. 71.5 ± 1.8%; P = 0.065) at 30 days post-transplantation. Donor upper lobe and subcarina Sto2 levels were also lower than the main carina (difference of -3.9 ± 1.5 and -4.8 ± 2.1, respectively; P < 0.05) at 30 days. Up-regulation of hypoxia-inducible genes VEGFA, FLT1, VEGFC, HMOX1, and TIE2 was significant in donor airways relative to native airways (all P < 0.05). VEGFA, KDR, and HMOX1 were associated with prolonged respiratory failure, prolonged hospitalization, extensive airway necrosis, and CAS (P < 0.05). These findings implicate donor bronchial hypoxia as a driving factor for post-transplantation airway complications. Strategies to improve airway oxygenation, such as bronchial artery re-anastomosis and hyperbaric oxygen therapy merit clinical investigation.

Relationship of fluviodeltaic facies to coal deposition in the lower Fort Union formation (Palaeocene), south-western North Dakota

USGS Publications Warehouse

Belt, Edward S.; Flores, Romeo M.; Warwick, Peter D.; Conway, Kevin M.; Johnson, Kirk R.; Waskowitz, Robert S.; Rahmani, R.A.; Flores, Romeo M.

1984-01-01

Facies analysis of the Ludlow and Tongue River Members of the Palaeocene Fort Union Formation provides an understanding of the relationship between fluviodeltaic environments and associated coal deposition in the south-western Williston Basin. The Ludlow Member consists of high-constructive delta facies that interfinger with brackish-water tongues of the Cannonball Member of the Fort Union Formation. The lower part of the Ludlow Member was deposited on a lower delta plain that consisted of interdistributary crevasse and subdelta lobes. The upper part of the Ludlow Member was deposited in meander belts of the upper delta plain. The delta plain facies of the Ludlow Member is overlain by alluvial plain facies consisting of swamp, crevasse-lobe, lacustrine, and trunk meander belt deposits of the Tongue River Member. The Ludlow delta is believed to have been fed by fluvial systems that probably flowed from the Powder River Basin to the Williston Basin undeterred by the Cedar Creek Anticline. However, the evidence indicates that the Cedar Creek Anticline was prominent enough, during early Tongue River Member deposition, to cause the obstruction of the regional fluvial system flowing from the SW, and the formation of local drainage.The Ludlow Member contains 18 coal beds in the area studied, of which the T-Cross and Yule coals are as thick as 4 m (12 ft). Abandoned delta lobes served as platforms where coals formed, which in turn, were drowned by mainly fresh water and subordinate brackish water. Repetition of deltaic sedimentation, abandonment, and occupation by swamp led to preservation of the T-Cross and Oyster coals in areas as extensive as 260 km2 (< 100 miles2).

[Combined pulmonary fibrosis and emphysema (CPFE)--limitation of usual lung function test and challenge at practice].

PubMed

Takai, Daiya

2014-12-01

Spirometry and the flow-volume curve test are commonly performed lung function tests. However, a unique clinical entity occasionally shows almost normal data in these tests, and is therefore missed on screening tests. The clinical entity of combined pulmonary emphysema and pulmdoary fibrosis was recognized and documented in the 90's in Japan, the USA, and Europe. Typical emphysema shows obstructive disorders, and pulmonary fibrosis shows restrictive disorders. Thus, the combination of both should lead to a combined disorder pattern in lung function tests, but this is not the case. In 2005, Cottin reported and redefined this combination of emphysema and fibrosis of the lung as "Combined Pulmonary Fibrosis and Emphysema" (CPFE). The patients are typically heavily smoking males who show an almost normal lung function. The upper lobe of these patients usually shows severe emphysema, which contributes to a static volume and a late phase in the forced volume test. On the other hand their lower lobe shows fibrotic change. The fibrotic portion contributes to early phase flow in the flow-volume curve. These mechanisms are a reason for the normal pattern appearance in lung function tests in CPFE patients. As a matter of course, these patients have damaged upper and lower lobes: their diffusing capacity of the lung shows a low performance, their saturation of blood hemoglobin decreases soon after light exercise, and their KL-6 (a blood marker of pulmonary fibrosis) usually shows a high value. They are considered a high risk group regarding complications of post-surgical treatment. Thus, when medical technologists identify suspicious cases, they should advise doctors to add diffusing capacity and KL-6 tests. (Review).

Bronchoscopic Thermal Vapor Ablation: Best Practice Recommendations from an Expert Panel on Endoscopic Lung Volume Reduction.

PubMed

Gompelmann, Daniela; Shah, Pallav L; Valipour, Arschang; Herth, Felix J F

2018-06-12

Bronchoscopic thermal vapor ablation (BTVA) represents one of the endoscopic lung volume reduction (ELVR) techniques that aims at hyperinflation reduction in patients with advanced emphysema to improve respiratory mechanics. By targeted segmental vapor ablation, an inflammatory response leads to tissue and volume reduction of the most diseased emphysematous segments. So far, BTVA has been demonstrated in several single-arm trials and 1 multinational randomized controlled trial to improve lung function, exercise capacity, and quality of life in patients with upper lobe-predominant emphysema irrespective of the collateral ventilation. In this review, we emphasize the practical aspects of this ELVR method. Patients with upper lobe-predominant emphysema, forced expiratory volume in 1 second (FEV1) between 20 and 45% of predicted, residual volume (RV) > 175% of predicted, and carbon monoxide diffusing capacity (DLCO) ≥20% of predicted can be considered for BTVA treatment. Prior to the procedure, a special software assists in identifying the target segments with the highest emphysema index, volume and the highest heterogeneity index to the untreated ipsilateral lung lobes. The procedure may be performed under deep sedation or preferably under general anesthesia. After positioning of the BTVA catheter and occlusion of the target segment by the occlusion balloon, heated water vapor is delivered in a predetermined specified time according to the vapor dose. After the procedure, patients should be strictly monitored to proactively detect symptoms of localized inflammatory reaction that may temporarily worsen the clinical status of the patient and to detect complications. As the data are still very limited, BTVA should be performed within clinical trials or comprehensive registries where the product is commercially available. © 2018 S. Karger AG, Basel.

Selecting the swimming mechanisms of colloidal particles: bubble propulsion versus self-diffusiophoresis.

PubMed

Wang, Sijia; Wu, Ning

2014-04-01

Bubble propulsion and self-diffusiophoresis are two common mechanisms that can drive autonomous motion of microparticles in hydrogen peroxide. Although microtubular particles, when coated with platinum in their interior concave surfaces, can propel due to the formation and release of bubbles from one end, the convex Janus particles usually do not generate any visible bubble. They move primarily due to the self-diffusiophoresis. Coincidentally, the platinum films on those particles were typically coated by physical evaporation. In this paper, we use a simple chemical deposition method to make platinum-polystyrene Janus dimers. Surprisingly, those particles are propelled by periodic growth and collapse of bubbles on the platinum-coated lobes. We find that both high catalytic activity and rough surface are necessary to change the propulsion mode from self-diffusiophoresis to bubble propulsion. Our Janus dimers, with combined geometric and interfacial anisotropy, also exhibit distinctive motions at the respective stages of bubble growth and collapse, which differ by 5-6 orders of magnitude in time. Our study not only provides insight into the link between self-diffusiophoresis and bubble propulsion but also reveals the intriguing impacts of the combined geometric and interfacial anisotropy on self-propulsion of particles.

The Role of Viscosity in TATB Hot Spot Ignition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fried, L E; Zepeda-Ruis, L; Howard, W M

2011-08-02

The role of dissipative effects, such as viscosity, in the ignition of high explosive pores is investigated using a coupled chemical, thermal, and hydrodynamic model. Chemical reactions are tracked with the Cheetah thermochemical code coupled to the ALE3D hydrodynamic code. We perform molecular dynamics simulations to determine the viscosity of liquid TATB. We also analyze shock wave experiments to obtain an estimate for the shock viscosity of TATB. Using the lower bound liquid-like viscosities, we find that the pore collapse is hydrodynamic in nature. Using the upper bound viscosity from shock wave experiments, we find that the pore collapse ismore » closest to the viscous limit.« less

DEPENDENCE OF THE Sr-TO-Ba AND Sr-TO-Eu RATIO ON THE NUCLEAR EQUATION OF STATE IN METAL-POOR HALO STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Famiano, M. A.; Kajino, T.; Aoki, W.

A model is proposed in which the dependence on the equation of state (EOS) of the scatter of [Sr/Ba] in metal-poor stars is studied. Light r-process element enrichment in these stars has been explained via a truncated r-process, or “tr-process.” The truncation of the r-process from a generic core-collapse event followed by a collapse into an accretion-induced black hole is examined in the framework of a galactic chemical evolution model. The constraints on this model imposed by observations of extremely metal-poor stars are explained, and the upper limits in the [Sr/Ba] distributions are found to be related to the nuclearmore » EOS in a collapse scenario. The scatter in [Sr/Ba] and [Sr/Eu] as a function of metallicity has been found to be consistent with turbulent ejection in core-collapse supernovae. Adaptations of this model are evaluated to account for the scatter in isotopic observables. This is done by assuming mixing in ejecta in a supernova event. Stiff EOS are eliminated by this model.« less

Terrane accumulation and collapse in central Europe: seismic and rheological constraints

NASA Astrophysics Data System (ADS)

Meissner, R.

1999-05-01

An attempt is made to compare the tectonic units and their evolution in central Europe with the deep seismic velocity structure and patterns of reflectivity. Caledonian and Variscan terrane accretion and orogenic collapse dominate the tectonic development in central and western Europe and have left their marks in a distinct velocity structure and crustal thickness as well as in the various reflectivity patterns. Whereas the memory of old collisional structures is still preserved in the rigid upper crust, collapse processes have formed and modified the lower crust. They have generally created rejuvenated, thin crusts with shallow Mohos. In the Variscan internides, the center of collision and post-orogenic heat pulses, the lower crust developed strong and thick seismic lamellae, the (cooler) externides show a thrust and shear pattern in the whole crust, and the North German Basin experienced large mafic intrusions in the lower crust and developed a high-velocity structure with only very thin lamellae on top of the Moho. The various kinds of reflectivity patterns in the lithosphere can be explained by a thermo-rheological model from terrane collision, with crustal thickening to collapse in a hot, post-orogenic setting.

Search for thermal X-ray features from the Crab nebula with the Hitomi soft X-ray spectrometer

NASA Astrophysics Data System (ADS)

Hitomi Collaboration; Aharonian, Felix; Akamatsu, Hiroki; Akimoto, Fumie; Allen, Steven W.; Angelini, Lorella; Audard, Marc; Awaki, Hisamitsu; Axelsson, Magnus; Bamba, Aya; Bautz, Marshall W.; Blandford, Roger; Brenneman, Laura W.; Brown, Gregory V.; Bulbul, Esra; Cackett, Edward M.; Chernyakova, Maria; Chiao, Meng P.; Coppi, Paolo S.; Costantini, Elisa; de Plaa, Jelle; de Vries, Cor P.; den Herder, Jan-Willem; Done, Chris; Dotani, Tadayasu; Ebisawa, Ken; Eckart, Megan E.; Enoto, Teruaki; Ezoe, Yuichiro; Fabian, Andrew C.; Ferrigno, Carlo; Foster, Adam R.; Fujimoto, Ryuichi; Fukazawa, Yasushi; Furuzawa, Akihiro; Galeazzi, Massimiliano; Gallo, Luigi C.; Gandhi, Poshak; Giustini, Margherita; Goldwurm, Andrea; Gu, Liyi; Guainazzi, Matteo; Haba, Yoshito; Hagino, Kouichi; Hamaguchi, Kenji; Harrus, Ilana M.; Hatsukade, Isamu; Hayashi, Katsuhiro; Hayashi, Takayuki; Hayashida, Kiyoshi; Hiraga, Junko S.; Hornschemeier, Ann; Hoshino, Akio; Hughes, John P.; Ichinohe, Yuto; Iizuka, Ryo; Inoue, Hajime; Inoue, Yoshiyuki; Ishida, Manabu; Ishikawa, Kumi; Ishisaki, Yoshitaka; Kaastra, Jelle; Kallman, Tim; Kamae, Tsuneyoshi; Kataoka, Jun; Katsuda, Satoru; Kawai, Nobuyuki; Kelley, Richard L.; Kilbourne, Caroline A.; Kitaguchi, Takao; Kitamoto, Shunji; Kitayama, Tetsu; Kohmura, Takayoshi; Kokubun, Motohide; Koyama, Katsuji; Koyama, Shu; Kretschmar, Peter; Krimm, Hans A.; Kubota, Aya; Kunieda, Hideyo; Laurent, Philippe; Lee, Shiu-Hang; Leutenegger, Maurice A.; Limousin, Olivier; Loewenstein, Michael; Long, Knox S.; Lumb, David; Madejski, Greg; Maeda, Yoshitomo; Maier, Daniel; Makishima, Kazuo; Markevitch, Maxim; Matsumoto, Hironori; Matsushita, Kyoko; McCammon, Dan; McNamara, Brian R.; Mehdipour, Missagh; Miller, Eric D.; Miller, Jon M.; Mineshige, Shin; Mitsuda, Kazuhisa; Mitsuishi, Ikuyuki; Miyazawa, Takuya; Mizuno, Tsunefumi; Mori, Hideyuki; Mori, Koji; Mukai, Koji; Murakami, Hiroshi; Mushotzky, Richard F.; Nakagawa, Takao; Nakajima, Hiroshi; Nakamori, Takeshi; Nakashima, Shinya; Nakazawa, Kazuhiro; Nobukawa, Kumiko K.; Nobukawa, Masayoshi; Noda, Hirofumi; Odaka, Hirokazu; Ohashi, Takaya; Ohno, Masanori; Okajima, Takashi; Ota, Naomi; Ozaki, Masanobu; Paerels, Frits; Paltani, Stéphane; Petre, Robert; Pinto, Ciro; Porter, Frederick S.; Pottschmidt, Katja; Reynolds, Christopher S.; Safi-Harb, Samar; Saito, Shinya; Sakai, Kazuhiro; Sasaki, Toru; Sato, Goro; Sato, Kosuke; Sato, Rie; Sato, Toshiki; Sawada, Makoto; Schartel, Norbert; Serlemtsos, Peter J.; Seta, Hiromi; Shidatsu, Megumi; Simionescu, Aurora; Smith, Randall K.; Soong, Yang; Stawarz, Łukasz; Sugawara, Yasuharu; Sugita, Satoshi; Szymkowiak, Andrew; Tajima, Hiroyasu; Takahashi, Hiromitsu; Takahashi, Tadayuki; Takeda, Shin'ichiro; Takei, Yoh; Tamagawa, Toru; Tamura, Takayuki; Tanaka, Takaaki; Tanaka, Yasuo; Tanaka, Yasuyuki T.; Tashiro, Makoto S.; Tawara, Yuzuru; Terada, Yukikatsu; Terashima, Yuichi; Tombesi, Francesco; Tomida, Hiroshi; Tsuboi, Yohko; Tsujimoto, Masahiro; Tsunemi, Hiroshi; Tsuru, Takeshi Go; Uchida, Hiroyuki; Uchiyama, Hideki; Uchiyama, Yasunobu; Ueda, Shutaro; Ueda, Yoshihiro; Uno, Shin'ichiro; Urry, C. Megan; Ursino, Eugenio; Watanabe, Shin; Werner, Norbert; Wilkins, Dan R.; Williams, Brian J.; Yamada, Shinya; Yamaguchi, Hiroya; Yamaoka, Kazutaka; Yamasaki, Noriko Y.; Yamauchi, Makoto; Yamauchi, Shigeo; Yaqoob, Tahir; Yatsu, Yoichi; Yonetoku, Daisuke; Zhuravleva, Irina; Zoghbi, Abderahmen; Tominaga, Nozomu; Moriya, Takashi J.

2018-03-01

The Crab nebula originated from a core-collapse supernova (SN) explosion observed in 1054 AD. When viewed as a supernova remnant (SNR), it has an anomalously low observed ejecta mass and kinetic energy for an Fe-core-collapse SN. Intensive searches have been made for a massive shell that solves this discrepancy, but none has been detected. An alternative idea is that SN 1054 is an electron-capture (EC) explosion with a lower explosion energy by an order of magnitude than Fe-core-collapse SNe. X-ray imaging searches were performed for the plasma emission from the shell in the Crab outskirts to set a stringent upper limit on the X-ray emitting mass. However, the extreme brightness of the source hampers access to its vicinity. We thus employed spectroscopic technique using the X-ray micro-calorimeter on board the Hitomi satellite. By exploiting its superb energy resolution, we set an upper limit for emission or absorption features from as yet undetected thermal plasma in the 2-12 keV range. We also re-evaluated the existing Chandra and XMM-Newton data. By assembling these results, a new upper limit was obtained for the X-ray plasma mass of ≲ 1 M⊙ for a wide range of assumed shell radius, size, and plasma temperature values both in and out of collisional equilibrium. To compare with the observation, we further performed hydrodynamic simulations of the Crab SNR for two SN models (Fe-core versus EC) under two SN environments (uniform interstellar medium versus progenitor wind). We found that the observed mass limit can be compatible with both SN models if the SN environment has a low density of ≲ 0.03 cm-3 (Fe core) or ≲ 0.1 cm-3 (EC) for the uniform density, or a progenitor wind density somewhat less than that provided by a mass loss rate of 10-5 M⊙ yr-1 at 20 km s-1 for the wind environment.

Abrupt climate change and collapse of deep-sea ecosystems

USGS Publications Warehouse

Yasuhara, Moriaki; Cronin, T. M.; Demenocal, P.B.; Okahashi, H.; Linsley, B.K.

2008-01-01

We investigated the deep-sea fossil record of benthic ostracodes during periods of rapid climate and oceanographic change over the past 20,000 years in a core from intermediate depth in the northwestern Atlantic. Results show that deep-sea benthic community "collapses" occur with faunal turnover of up to 50% during major climatically driven oceanographic changes. Species diversity as measured by the Shannon-Wiener index falls from 3 to as low as 1.6 during these events. Major disruptions in the benthic communities commenced with Heinrich Event 1, the Inter-Aller??d Cold Period (IACP: 13.1 ka), the Younger Dryas (YD: 12.9-11.5 ka), and several Holocene Bond events when changes in deep-water circulation occurred. The largest collapse is associated with the YD/IACP and is characterized by an abrupt two-step decrease in both the upper North Atlantic Deep Water assemblage and species diversity at 13.1 ka and at 12.2 ka. The ostracode fauna at this site did not fully recover until ???8 ka, with the establishment of Labrador Sea Water ventilation. Ecologically opportunistic slope species prospered during this community collapse. Other abrupt community collapses during the past 20 ka generally correspond to millennial climate events. These results indicate that deep-sea ecosystems are not immune to the effects of rapid climate changes occurring over centuries or less. ?? 2008 by The National Academy of Sciences of the USA.

A Subject-Specific Acoustic Model of the Upper Airway for Snoring Sounds Generation

PubMed Central

Saha, Shumit; Bradley, T. Douglas; Taheri, Mahsa; Moussavi, Zahra; Yadollahi, Azadeh

2016-01-01

Monitoring variations in the upper airway narrowing during sleep is invasive and expensive. Since snoring sounds are generated by air turbulence and vibrations of the upper airway due to its narrowing; snoring sounds may be used as a non-invasive technique to assess upper airway narrowing. Our goal was to develop a subject-specific acoustic model of the upper airway to investigate the impacts of upper airway anatomy, e.g. length, wall thickness and cross-sectional area, on snoring sounds features. To have a subject-specific model for snoring generation, we used measurements of the upper airway length, cross-sectional area and wall thickness from every individual to develop the model. To validate the proposed model, in 20 male individuals, intensity and resonant frequencies of modeled snoring sounds were compared with those measured from recorded snoring sounds during sleep. Based on both modeled and measured results, we found the only factor that may positively and significantly contribute to snoring intensity was narrowing in the upper airway. Furthermore, measured resonant frequencies of snoring were inversely correlated with the upper airway length, which is a risk factor for upper airway collapsibility. These results encourage the use of snoring sounds analysis to assess the upper airway anatomy during sleep. PMID:27210576

Fernandina caldera collapse morphology in geometric and dynamic comparison to sandbox models, subsidence sinks over nuclear-explosion cavities, and some other calderas

NASA Astrophysics Data System (ADS)

Howard, K. A.

2009-12-01

The 1968 collapse structure of Fernandina caldera (1.5 km3 collapsed) and also the smaller Darwin Bay caldera in Galápagos each closely resembles morphologically the structural zoning of features found in depressions collapsed into nuclear-explosion cavities (“sinks” of Houser, 1969) and in coherent sandbox-collapse models. Coherent collapses characterized by faulting, folding, and organized structure contrast with spalled pit craters (and lab experiments with collapsed powder) where disorganized piles of floor rubble result from tensile failure of the roof. Subsidence in coherent mode, whether in weak sand in the lab, stronger desert alluvium for nuclear-test sinks, or in hard rock for calderas, exhibits consistent morphologic zones. Characteristically in the sandbox and the nuclear-test analogs these include a first-formed central plug that drops along annular reverse faults. This plug and a surrounding inward-tilted or monoclinal ring (hanging wall of the reverse fault) contract as the structure expands outward by normal faulting, wherein peripheral rings of distending material widen the upper part of the structure along inward-dipping normal faults and compress inner zones and help keep them intact. In Fernandina, a region between the monocline and the outer zone of normal faulting is interpreted, by comparison to the analogs, to overlie the deflation margin of an underlying magma chamber. The same zoning pattern is recognized in structures ranging from sandbox subsidence features centimeters across, to Alae lave lake and nuclear-test sinks tens to hundreds of meters across, to Fenandina’s 2x4 km-wide collapse, to Martian calderas tens of kilometers across. Simple dimensional analysis using the height of cliffs as a proxie for material strength implies that the geometric analogs are good dynamic analogs, and validates that the pattern of both reverse and normal faulting that has been reported consistently from sandbox modeling applies widely to calderas.

West Candor Chasma

NASA Technical Reports Server (NTRS)

1996-01-01

During its examination of Mars, the Viking 1 spacecraft returned images of Valles Marineris, a huge canyon system 5,000 km long, up to 240 km wide, and 6.5 km deep, whose connected chasma or valleys may have formed from a combination of erosional collapse and structural activity. The view shows west Candor Chasma, one of the connected valleys of Valles Marineris; north toward top of frame. The image is a composite of Viking high-resolution (about 80 m/pixel or picture element) images in black and white and low resolution (about 250 m/pixel) images in color. The Viking 1 craft landed on Mars in July of 1976. West Candor Chasma occupies the westernmost part of the large west-northwest-trending trough of Candor Chasma. This section is about 150 km wide. West Candor Chasma is bordered on the north and south by straight-walled cliffs, most likely faults, and on its west by two segments of north-northeast-trending cliffs. The north wall is dissected by landslide scars forming reentrants filled with landslide debris. The south wall shows spur-and-gully morphology and smooth sections. The high-standing central mesa, informally dubbed Red Mesa has several curvilinear reentrants carved into the caprock, whose anomalously colored layers were interpreted to be caused by young hydrothermal alteration products (Geissler et al., 1993, Icarus, v. 106, p. 380-391). Light-colored lobes flow away from the top of the interior stack and then flow around and embay the same layered stack from which they originated. One of these apparent flow features is composed of at least two or perhaps even three huge, superposed, vaguely layered, very rugged, light-colored lobes as much as 100 km long, 20 km wide, and over 2 km thick. The layered deposits below the caprock also merge with a chaotic material that has local lobate fronts and overlaps landslide deposits. Hummocky material, similar in hue to wall rock, fills the southwestern-most region of west Candor Chasma and is perhaps as much as 3 km thick (Lucchitta, 1990, Icarus, v. 86, p. 476- 509). The light-colored lobes, chaotic material, and hummocky fill may be mass wasting deposits due to wholesale collapse of older interior deposits (Lucchitta, 1996, LPSC XXVII abs., p. 779- 780); this controversial idea requires that the older layered deposits were saturated with ice, perhaps from former lakes and that young volcanism and/or tectonism melted the ice and made the material flow.

Transitions in Lava Emplacement Recorded in the Deccan Traps Sequence (India)

NASA Astrophysics Data System (ADS)

Vanderkluysen, L.; Self, S.; Jay, A. E.; Sheth, H. C.; Clarke, A. B.

2015-12-01

Transitions in the style of lava flow emplacement are recognized in the stratigraphic sequence of several mafic large igneous provinces (LIPs), including the Etendeka (Namibia), the Faeroe Islands (North Atlantic LIP), the Ethiopian Traps, and the Deccan Traps (India). These transitions, from units dominated by meter-sized pāhoehoe toes and lobes to those dominated by inflated sheet lobes tens to hundreds of meters in width and meters to tens of meters in height, seems to be a fundamental feature of LIP emplacement. In the Deccan, this volcanological transition is thought to coincide with deeper changes to the volcano-magmatic system expressed, notably, in the trace element and isotopic signature of erupted flows. We investigated this transition in the Deccan Traps by logging eight sequences along the Western Ghats, an escarpment in western India where the Deccan province is thickest and best exposed. The Deccan province, which once covered ~1 million km2 of west-central India, is subdivided in eleven chemo-stratigraphic formations in the type sections of the Western Ghats. Where the lower Deccan formations are exposed, we found that as much as 65% of the exposed thickness (below the Khandala Formation) is made up of sheet lobes, from 40% in the Bhimashankar Formation to 75% in the Thakurvadi Formation. Near the bottom of the sequence, 25% of the Neral Formation is composed of sheet lobes ≥15 m in thickness. On this basis, the traditional view that inflated sheet lobes are an exclusive feature of the upper part of the stratigraphy must be challenged. Several mechanisms have been proposed to explain the development of compound flows and inflated sheet lobes, involving one or more of the following factors: underlying slope, varying effusion rate, and source geometry. Analogue experiments are currently under way to test the relative influence of each of these factors in the development of different lava flow morphologies in LIPs.

Geologic Setting of Mosul Dam and Its Engineering Implications

DTIC Science & Technology

2007-09-01

thought that an increase in vol- ume, produced during alteration of interbedded anhydrite to gypsum, generated sufficient pressure to fracture the...construction.. ..................................................................23 Figure 8. Geologic sections with water- pressure test values and...contains fragments or clasts of limestone, dolomite , or larger pieces of insoluble rocks of collapsed material. The upper portion of the accumulation

Integrating Health Status and Survival Data

PubMed Central

Benzo, Roberto; Farrell, Max H.; Chang, Chung-Chou H.; Martinez, Fernando J.; Kaplan, Robert; Reilly, John; Criner, Gerard; Wise, Robert; Make, Barry; Luketich, James; Fishman, Alfred P.; Sciurba, Frank C.

2009-01-01

Rationale: In studies that address health-related quality of life (QoL) and survival, subjects who die are usually censored from QoL assessments. This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem. Objectives: To determine the effect of lung volume reduction surgery (LVRS) on a composite endpoint consisting of the occurrence of death or a clinically meaningful decline in QoL defined as an increase of at least eight points in the St. George's Respiratory Questionnaire total score from the National Emphysema Treatment Trial. Methods: In patients with chronic obstructive pulmonary disease and emphysema randomized to receive medical treatment (n = 610) or LVRS (n = 608), we analyzed the survival to the composite endpoint, the hazard functions and constructed prediction models of the slope of QoL decline. Measurements and Main Results: The time to the composite endpoint was longer in the LVRS group (2 years) than the medical treatment group (1 year) (P < 0.0001). It was even longer in the subsets of patients undergoing LVRS without a high risk for perioperative death and with upper-lobe-predominant emphysema. The hazard for the composite event significantly favored the LVRS group, although it was most significant in patients with predominantly upper-lobe emphysema. The beneficial impact of LVRS on QoL decline was most significant during the 2 years after LVRS. Conclusions: LVRS has a significant effect on the composite QoL-survival endpoint tested, indicating its meaningful palliative role, particularly in patients with upper-lobe–predominant emphysema. PMID:19483114

Geochemistry and mineralogy of late Quaternary loess in the upper Mississippi River valley, USA: Provenance and correlation with Laurentide Ice Sheet history

USGS Publications Warehouse

Muhs, Daniel; Bettis, E. Arthur; Skipp, Gary L.

2018-01-01

The midcontinent of North America contains some of the thickest and most extensive last-glacial loess deposits in the world, known as Peoria Loess. Peoria Loess of the upper Mississippi River valley region is thought to have had temporally varying glaciogenic sources resulting from inputs of sediment to the Mississippi River from different lobes of the Laurentide Ice Sheet. Here, we explore a new method of determining loess provenance using K/Rb and K/Ba values (in K-feldspars and micas) in loess from a number of different regions in North America. Results indicate that K/Rb and K/Ba values can distinguish loess originating from diverse geologic terrains in North America. Further, different loess bodies that are known to have had the same source sediments (using other criteria) have similar K/Rb and K/Ba values. We also studied three thick loess sections in the upper Mississippi River valley region. At each site, the primary composition of the loess changed over the course of the last glacial period, and K/Rb and K/Ba values parallel changes in carbonate mineral content and clay mineralogy. We thus confirm conclusions of earlier investigators that loess composition changed as a result of the shifting dominance of different lobes of the Laurentide Ice Sheet and the changing course of the Mississippi River. We conclude that K/Rb and K/Ba values are effective, robust, and rapid indicators of loess provenance that can be applied to many regions of the world.

Geochemistry and mineralogy of late Quaternary loess in the upper Mississippi River valley, USA: Provenance and correlation with Laurentide Ice Sheet history

NASA Astrophysics Data System (ADS)

Muhs, Daniel R.; Bettis, E. Arthur; Skipp, Gary L.

2018-05-01

The midcontinent of North America contains some of the thickest and most extensive last-glacial loess deposits in the world, known as Peoria Loess. Peoria Loess of the upper Mississippi River valley region is thought to have had temporally varying glaciogenic sources resulting from inputs of sediment to the Mississippi River from different lobes of the Laurentide Ice Sheet. Here, we explore a new method of determining loess provenance using K/Rb and K/Ba values (in K-feldspars and micas) in loess from a number of different regions in North America. Results indicate that K/Rb and K/Ba values can distinguish loess originating from diverse geologic terrains in North America. Further, different loess bodies that are known to have had the same source sediments (using other criteria) have similar K/Rb and K/Ba values. We also studied three thick loess sections in the upper Mississippi River valley region. At each site, the primary composition of the loess changed over the course of the last glacial period, and K/Rb and K/Ba values parallel changes in carbonate mineral content and clay mineralogy. We thus confirm conclusions of earlier investigators that loess composition changed as a result of the shifting dominance of different lobes of the Laurentide Ice Sheet and the changing course of the Mississippi River. We conclude that K/Rb and K/Ba values are effective, robust, and rapid indicators of loess provenance that can be applied to many regions of the world.

Distribution of "Compound" and "Simple" Flows in the Deccan Traps (India)

NASA Astrophysics Data System (ADS)

Vanderkluysen, L.; Self, S.; Jay, A. E.; Sheth, H. C.; Clarke, A. B.

2014-12-01

The Deccan Traps are a dominantly mafic large igneous province (LIP) that, prior to erosion, covered ~1 million km2 of west-central India with lava flows. The type sections of the Western Ghats escarpment, where the Deccan lava pile reaches a maximum reconstructed stratigraphic thickness of ~3400 m, are subdivided into eleven formations defined on chemo-stratigraphic grounds. Earlier work recognized that emplacement of Deccan basalt flows primarily occurs following two main modes: as a stack of meter-sized pāhoehoe toes and lobes, termed "compound" flows; or as inflated sheet lobes tens to hundreds of meters in width and meters to tens of meters in height, previously termed "simple" flows. Initially, the distribution of small lobes and sheet lobes in the Deccan was thought to be controlled by distance from source, but later work suggested the distribution to be mainly controlled along stratigraphic, formational boundaries, with six of the lower formations being composed exclusively of compound flows, and the upper 4-5 formations being wholly built of sheet lobes. This simple stratigraphic subdivision of lava flow morphologies has also been documented in the volcanic architecture of other LIPs, e.g., the Etendeka, the Ethiopian Traps, and in the Faeroe Islands (North Atlantic LIP). Upon examination of eight sections carefully logged along the Western Ghats, this traditional view must be challenged. Where the lower Deccan formations crop out, we found that as much as 65% of the exposed thickness (below the Khandala Formation) is made up of sheet lobes, from 40% in the Bhimashankar Formation to 75% in the Thakurvadi Formation. Near the bottom of the sequence, 25% of the Neral Formation is composed of sheet lobes ≥15 m in thickness. This distribution in lava flow morphology does not seem to be noticeably affected by the inferred distance to the source (based on the location of similar-composition dikes for each formation). Several mechanisms have been proposed to explain the development of compound flows and inflated sheet lobes, involving one or more of the following factors: underlying slope, varying effusion rate, and source geometry. Analogue experiments are currently under way to test the relative influence of each of these factors in the development of different lava flow morphologies in LIPs.

Ganges Landslides

NASA Technical Reports Server (NTRS)

2005-01-01

This Mars Global Surveyor (MGS) Orbiter Camera (MOC) image shows a high resolution view of portions of the lobes of several landslide deposits in Ganges Chasma. Dark material near the bottom (south) end of the image is windblown sand.

Location near: 8.2oS, 44.3oW Image width: 3.0 km (1.9 mi) Illumination from: upper left Season: Southern Winter

Brain metastasis from ovarian cancer: case report and review of the literature.

PubMed

Hu, Xi-Quan; Imitola, Jaime; Kim, Ryan Y; Mahta, Ali; Kesari, Santosh

2012-06-01

We present an 80-year-old lady with a history of ovarian cancer, who manifested with seizure and left upper extremity weakness. The imaging revealed a multilobulated mass within right parietal lobe. She underwent surgical resection and the pathology was compatible with metastasis from ovarian adenocarcinoma. She received a whole brain radiation therapy and she has been in remission for more than 2 years.

Lung Abscess as Delayed Manifestation of Pulmonary Arterial Narrowing After Sleeve Resection.

PubMed

Frenzen, Frederik S; Lesser, Thomas; Platzek, Ivan; Riede, Frank-Thomas; Kolditz, Martin

2017-08-01

A patient who had undergone right upper bilobectomy because of a carcinoid experienced lung abscesses 17 months after operation. After recurrences, despite different antibiotic agents, dual-energy computed tomography showed subtotal stenosis of the right lower lobe pulmonary artery with marked pulmonary perfusion-reduction. Rare causes of lung-abscesses should be considered. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Comparison of distinctive models for calculating an interlobar emphysema heterogeneity index in patients prior to endoscopic lung volume reduction.

PubMed

Theilig, Dorothea; Doellinger, Felix; Poellinger, Alexander; Schreiter, Vera; Neumann, Konrad; Hubner, Ralf-Harto

2017-01-01

The degree of interlobar emphysema heterogeneity is thought to play an important role in the outcome of endoscopic lung volume reduction (ELVR) therapy of patients with advanced COPD. There are multiple ways one could possibly define interlobar emphysema heterogeneity, and there is no standardized definition. The aim of this study was to derive a formula for calculating an interlobar emphysema heterogeneity index (HI) when evaluating a patient for ELVR. Furthermore, an attempt was made to identify a threshold for relevant interlobar emphysema heterogeneity with regard to ELVR. We retrospectively analyzed 50 patients who had undergone technically successful ELVR with placement of one-way valves at our institution and had received lung function tests and computed tomography scans before and after treatment. Predictive accuracy of the different methods for HI calculation was assessed with receiver-operating characteristic curve analysis, assuming a minimum difference in forced expiratory volume in 1 second of 100 mL to indicate a clinically important change. The HI defined as emphysema score of the targeted lobe (TL) minus emphysema score of the ipsilateral nontargeted lobe disregarding the middle lobe yielded the best predicative accuracy (AUC =0.73, P =0.008). The HI defined as emphysema score of the TL minus emphysema score of the lung without the TL showed a similarly good predictive accuracy (AUC =0.72, P =0.009). Subgroup analysis suggests that the impact of interlobar emphysema heterogeneity is of greater importance in patients with upper lobe predominant emphysema than in patients with lower lobe predominant emphysema. This study reveals the most appropriate ways of calculating an interlobar emphysema heterogeneity with regard to ELVR.

Altered Brain Network in Amyotrophic Lateral Sclerosis: A Resting Graph Theory-Based Network Study at Voxel-Wise Level.

PubMed

Zhou, Chaoyang; Hu, Xiaofei; Hu, Jun; Liang, Minglong; Yin, Xuntao; Chen, Lin; Zhang, Jiuquan; Wang, Jian

2016-01-01

Amyotrophic lateral sclerosis (ALS) is a rare degenerative disorder characterized by loss of upper and lower motor neurons. Neuroimaging has provided noticeable evidence that ALS is a complex disease, and shown that anatomical and functional lesions extend beyond precentral cortices and corticospinal tracts, to include the corpus callosum; frontal, sensory, and premotor cortices; thalamus; and midbrain. The aim of this study is to investigate graph theory-based functional network abnormalities at voxel-wise level in ALS patients on a whole brain scale. Forty-three ALS patients and 44 age- and sex-matched healthy volunteers were enrolled. The voxel-wise network degree centrality (DC), a commonly employed graph-based measure of network organization, was used to characterize the alteration of whole brain functional network. Compared with the controls, the ALS patients showed significant increase of DC in the left cerebellum posterior lobes, bilateral cerebellum crus, bilateral occipital poles, right orbital frontal lobe, and bilateral prefrontal lobes; significant decrease of DC in the bilateral primary motor cortex, bilateral sensory motor region, right prefrontal lobe, left bilateral precuneus, bilateral lateral temporal lobes, left cingulate cortex, and bilateral visual processing cortex. The DC's z-scores of right inferior occipital gyrus were significant negative correlated with the ALSFRS-r scores. Our findings confirm that the regions with abnormal network DC in ALS patients were located in multiple brain regions including primary motor, somatosensory and extra-motor areas, supporting the concept that ALS is a multisystem disorder. Specifically, our study found that DC in the visual areas was altered and ALS patients with higher DC in right inferior occipital gyrus have more severity of disease. The result demonstrated that the altered DC value in this region can probably be used to assess severity of ALS.

In-vitro evaluation of limitations and possibilities for the future use of intracorporeal gas exchangers placed in the upper lobe position.

PubMed

Schumer, Erin; Höffler, Klaus; Kuehn, Christian; Slaughter, Mark; Haverich, Axel; Wiegmann, Bettina

2018-03-01

The lack of donor organs has led to the development of alternative "destination therapies", such as a bio-artificial lung (BA) for end-stage lung disease. Ultimately aiming at a fully implantable BA, general capabilities and limitations of different oxygenators were tested based on the model of BA positioning at the right upper lobe. Three different-sized oxygenators (neonatal, paediatric, and adult) were tested in a mock circulation loop regarding oxygenation and decarboxylation capacities for three respiratory pathologies. Blood flows were imitated by a roller pump, and respiration was imitated by a mechanical ventilator with different FiO 2 applications. Pressure drops across the oxygenators and the integrity of the gas-exchange hollow fibers were analyzed. The neonatal oxygenator proved to be insufficient regarding oxygenation and decarboxylation. Despite elevated pCO 2 levels, the paediatric and adult oxygenators delivered comparable sufficient oxygen levels, but sufficient decarboxylation across the oxygenators was ensured only at flow rates of 0.5 L min. Only the adult oxygenator indicated no significant pressure drops. For all tested conditions, gas-exchange hollow fibers remained intact. This is the first study showing the general feasibility of delivering sufficient levels of gas exchange to an intracorporeal BA via patient's breathing, without damaging gas-exchange hollow fiber membranes.

Deposystem architectures and lithofacies of a submarine fan-dominated deep sea succession in an orogen: A case study from the Upper Triassic Langjiexue Group of southern Tibet

NASA Astrophysics Data System (ADS)

Zhang, Chaokai; Li, Xianghui; Mattern, Frank; Mao, Guozheng; Zeng, Qinggao; Xu, Wenli

2015-11-01

Over thirty stratigraphic sections of the Himalaya orogen Upper Triassic Langjiexue Group in southern Tibet, China, were studied to interpret the environments and lithofacies. The facies associations channel (A), lobe (B), levee-interchannel (C), and basin plain (D) with nine facies (A1-3, B1-3, and C1-3) were distinguished. They form six architectural elements: channel-interchannel, overbank-levee, crevasse-splay, outer fan-lobe, fan-fringe, and basin plain. Taking into account the facies analysis, (sub-) deposystem correlation, paleocurrent dispersal pattern, and restoration of primary stratal width, the Langjiexue Group displays the architecture of a coalescing submarine fan-dominated deep sea deposystem, measuring about 400-500 km × 600-700 km in size or even more, one of the largest pre-Cenozoic submarine fans ever reported. Subdivisionally, four fans, lacking inner fans, could have coalesced laterally within the submarine fan deposystem, and at least six submarine fan developments were vertically succeeded by mid- to outer-fan deposits with progradational to retrogradational successions. According to the range of 30-70% of sandstone content, the fan deposystem is mud- and sand-rich, suggesting a medium-far (over 400-600 km) transport of sediment from the source area.

Pulmonary atelectasis in newborns with clinically treatable diseases who are on mechanical ventilation: clinical and radiological aspects

PubMed Central

Dominguez, Mariana Chiaradia; Alvares, Beatriz Regina

2018-01-01

Objective To analyze the radiological aspects of pulmonary atelectasis in newborns on mechanical ventilation and treated in an intensive care unit, associating the characteristics of atelectasis with the positioning of the head and endotracheal tube seen on the chest X-ray, as well as with the clinical variables. Materials and Methods This was a retrospective cross-sectional study of 60 newborns treated between 1985 and 2015. Data were collected from medical records and radiology reports. To identify associations between variables, we used Fisher's exact test. The level of significance was set at p < 0.05. Results The clinical characteristics associated with improper positioning of the endotracheal tube were prematurity and a birth weight of less than 1000 g. Among the newborns evaluated, the most common comorbidity was hyaline membrane disease. Atelectasis was seen most frequently in the right upper lobe, although cases of total atelectasis were more common in the left lung. Malpositioning of the head showed a trend toward an association with atelectasis in the left upper lobe. Conclusion Pulmonary atelectasis is a common complication in newborns on mechanical ventilation. Radiological evaluation of the endotracheal tube placement provides relevant information for the early correction of this condition. PMID:29559762

Magnetic Susceptibility and Mineral Zonations Controlled by Provenance in Loess along the Illinois and Central Mississippi River Valleys

USGS Publications Warehouse

Grimley, D.A.; Follmer, L.R.; McKay, E.D.

1998-01-01

Magnetic susceptibility (MS) patterns have proven useful for regional stratigraphic correlations of zones within thick, oxidized Peoria and Roxana Silts along the Illinois and Central Mississippi River valleys for more than 350 km. Variations in MS of C horizon loess are controlled by silt-sized magnetite content and are interpreted to reflect changes in sediment provenance due to fluctuations of the Superior and Lake Michigan glacier lobes and the diversion of the Mississippi River to its present course. Grain size distributions and scanning electron microscopic observations indicate that stratigraphic changes in MS are not significantly influenced by eolian sorting or diagenetic dissolution, respectively. Three compositional zones (lower, middle, and upper) are delineated within Peoria Silt which usually can be traced in the field by MS, the occurrence of clay beds, interstadial soils, and/or subtle color changes. These zones can be correlated with, but are generally of more practical use than, previously studied dolomite zones (McKay, 1977) or clay mineral zones (Frye et al., 1968). However, mineralogical analyses can help to substantiate zone boundaries when in question. MS and compositional zones may indirectly record a climatic signal, primarily through the effect that global cooling has had on ice lobe fluctuations in the Upper Mississippi drainage basin. ?? 1998 University of Washington.

Pleuroparenchymal fibroelastosis after allogenic hematopoietic stem cell transplantation: important histological component of late-onset noninfectious pulmonary complication accompanied with recurrent pneumothorax.

PubMed

Matsui, Takahiro; Maeda, Tetsuo; Kida, Toru; Fujita, Jiro; Tsuji, Hiromi; Morii, Eiichi; Kanakura, Yuzuru

2016-10-01

Late-onset noninfectious pulmonary complication after allogenic hematopoietic stem cell transplantation is an important contributing factor associated with high rate morbidity and mortality. We report a case with pleuroparenchymal fibroelastosis (PPFE) occurred after allogenic bone marrow transplantation. The onset was infiltrative shadows in upper lobes, and the haziness spread gradually throughout the lungs with recurrent episodes of pneumothorax in both lungs. Progressive respiratory failure in course of adrenocortical steroid administration eventually caused death. Histological examination in general autopsy showed patchy subpleural fibrosis predominantly distributed in the upper lobes with substantial density rise of elastic fibers in the subpleural area, consistent with the diagnosis of PPFE. PPFE after allogenic transplantation has been seldom reported to date, but it is one of the most important histological components of late-onset noninfectious pulmonary complication after allogenic transplantation characterized by recurrent pneumothorax. Retrospective analysis in our case indicates early diagnosis may be possible by histological evaluation of elastic fibers in lung specimen when pneumothorax is treated surgically. This case suspects that it is important for hematologist and pathologist to aware this progressive disease along with information of histological characteristics, therefore, leading to the establishment of therapeutic strategies and the improvement of poor prognosis.

Haemosuccus pancreaticus, an uncommon cause of upper gastro intestinal bleeding: Case report and review of the literature.

PubMed

Shah, Amir Ali; Charon, Jean Pierre

2015-06-01

Haemosuccus Pancreaticus is defined as upper gastro intestinal (GI) bleeding from the ampula of vater via the pancreatic duct. It is most commonly associated with pancreatic inflammation, erosion of the pancrease by aneurysm or pseudo-aneurysm of the splenic artery. We report a 69 year old man with previous history of acute pancreatitis who was admitted with recurrent haematemesis. Initial upper GI endocopy was normal, while admitted, he collapse with abdominal pain and hypotension. He was resuscitated with blood and intravenous fluid. Repeat upper GI endocopy showed fresh blood in the duodenum, but no active bleeding site was demonstrated. An urgent coeliac axis CT angiogram was done which showed an splenic artery pseudo-aneurysm, which was successfully embolized. Patient is well 9 months after the procedure. This case highlights the importance of considering coeliac axis CT angiogram as part of investigation for obscure GI bleeding.

Sciatic Nerve Stimulation and its Effects on Upper Airway Resistance in the Anesthetized Rabbit Model Relevant to Sleep Apnea.

PubMed

Schiefer, Matthew; Gamble, Jenniffer; Strohl, Kingman Perkins

2018-06-07

Obstructive sleep apnea (OSA) is a disorder characterized by collapse of the velopharynx and/or oropharynx during sleep when drive to the upper airway is reduced. Here, we explore an indirect approach for activation of upper airway muscles which might affect airway dynamics- unilateral electrical stimulation of the afferent fibers of the sciatic nerve- in an anesthetized rabbit model. A nerve cuff electrode was placed around the sciatic and hypoglossal nerves to deliver stimulus while air flow, air pressure, and alae nasi electromyogram (EMG) were monitored both prior to and after sciatic transection. Sciatic nerve stimulation increased respiratory effort, rate, and alae nasi EMG, which persisted for seconds after stimulation; however, upper airway resistance was unchanged. Hypoglossal stimulation reduced resistance without altering drive. While sciatic nerve stimulation is not ideal for treating obstructive sleep apnea, it remains a target for altering respiratory drive.

Phrenic Nerve Reconstruction and Bilateral Diaphragm Plication After Lobectomy.

PubMed

Shinohara, Shuichi; Yamada, Tetsu; Ueda, Mitsuhiro; Ishinagi, Hiroyoshi; Matsuoka, Takahisa; Nagai, Shinjiro; Matsuoka, Katsunari; Miyamoto, Yoshihiro

2017-07-01

A 49-year-old man with left phrenic nerve paralysis caused by mediastinal tumor resection 28 years earlier was found to have a nodule in the right upper lobe. The right phrenic nerve was severed during right upper lobectomy but was reconstructed along with bilateral plication of the diaphragm. The patient was weaned from the ventilator during the daytime on postoperative day 13 and was discharged home on postoperative day 48. Three months postoperatively, chest fluoroscopic imaging showed recovery of movement of the right diaphragm. Nerve conduction studies showed improvement of function of the reconstructed right phrenic nerve. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Lung abscess caused by Mycoplasma pneumoniae.

PubMed

Omae, Takashi; Matsubayashi, Tadashi

2015-08-01

A 10-year-old boy with West syndrome was referred to hospital because of high fever and cough. Chest X-ray and computed tomography showed consolidation with an abscess in the right upper lobe. Laboratory data indicated cytokine storm. Various antibacterial agents and additional corticosteroid were unable to control the hypercytokinemia, which was suppressed after cyclosporine A was started. The lung abscess remained, however, and right upper lobectomy was performed. Culture from the abscess showed no growth, while polymerase chain reaction assay indicated Mycoplasma pneumoniae DNA. Serum passive agglutinin titer for M. pneumoniae was significantly elevated in the convalescent phase. These findings are strong evidence that the lung abscess was caused by M. pneumoniae infection. © 2015 Japan Pediatric Society.

[A case of hereditary sensory and autonomic neuropathy type 1E with frontal lobe dysfunction as an initial symptom].

PubMed

Watanabe, Masashi; Matsumoto, Yushi; Okamoto, Kensho; Okuda, Bungo; Mizuta, Ikuko; Mizuno, Toshiki

2017-12-27

A 49-year-old man had developed gradually personality change, gait disturbance, and hearing loss for five years. On admission, he presented with frontal release signs, stuttering, vertical gaze palsy, sensorineural deafness, muscle rigidity, ataxia, and sensory disturbance with areflexia in the lower extremities. Brain MRI demonstrated atrophy in the cerebellum and midbrain tegmentum as well as cerebral atrophy, predominantly in the frontal lobe. He was tentatively diagnosed as progressive supranuclear palsy on the basis of clinical features and imagings. On nerve conduction study, no sensory nerve action potentials were elicited in the upper and lower extremities. Details of family history revealed a hereditary sensory neuropathy with autosomal dominant inheritance in his relatives. Because genetic analysis showed a rare missense mutation (c.1483T>C, p.Y495H) in DNA methyltransferase 1 gene, we diagnosed him as having hereditary sensory and autonomic neuropathy type 1E (HSAN1E). In addition, p.M232R mutation in prion protein gene was detected. It should be kept in mind that there are some patients with HSAN1E presenting with frontal lobe dysfunction as an initial symptom and with clinical features mimicking progressive supranuclear palsy.

Supernova Neutrino-Burst Search with the AMANDA Detector

NASA Astrophysics Data System (ADS)

Neunhöffer, T.; AMANDA Collaboration

2001-08-01

The neutrino telescope AMANDA located deep in the South Pole ice has been used to search for bursts of low energy neutrinos originating from supernova collapses. In the data sets taken during 1997 and 1998 with 302 of the detector's optical modules no candidate events were found. With this detector configuration 70% of the galaxy is covered with 90% efficiency allowing for one background fake per year. An upper limit at the 90% c.l. on the rate of star collapses in the Milky Way is derived, yielding 4.3 events per year. The new supernova readout system, which has been installed in 2000 and 2001, is discussed. With the full (19string) system we expect to cover 97% of our galaxy.

Preferential flows and soil moistures on a Benggang slope: Determined by the water and temperature co-monitoring

NASA Astrophysics Data System (ADS)

Tao, Yu; He, Yangbo; Duan, Xiaoqian; Zou, Ziqiang; Lin, Lirong; Chen, Jiazhou

2017-10-01

Soil preferential flow (PF) has important effects on rainfall infiltration, moisture distribution, and hydrological and ecological process; but it is very difficult to monitor and characterize on a slope. In this paper, soil water and soil temperature at 20, 40, 60, 80 cm depths in six positions were simultaneously monitored at high frequency to confirm the occurrence of PF at a typical Benggang slope underlain granite residual deposits, and to determine the interaction of soil moisture distribution and Benggang erosion. In the presence of PF, the soil temperature was first (half to one hour) governed by the rainwater temperature, then (more than one hour) governed by the upper soil temperature; in the absence of PF (only matrix flow, MF), the soil temperature was initially governed by the upper soil temperature, then by the rainwater temperature. The results confirmed the water replacement phenomenon in MF, thus it can be distinguished from PF by additional temperature monitoring. It indicates that high frequency moisture and temperature monitoring can determine the occurrence of PF and reveal the soil water movement. The distribution of soil water content and PF on the different positions of the slope showed that a higher frequency of PF resulted in a higher variation of average of water content. The frequency of PF at the lower position can be three times as that of the upper position, therefore, the variation coefficient of soil water content increased from 4.67% to 12.68% at the upper position to 8.18%-33.12% at the lower position, where the Benggang erosion (soil collapse) was more possible. The results suggest strong relationships between PF, soil water variation, and collapse activation near the Benggang wall.

In vivo size and shape measurement of the human upper airway using endoscopic longrange optical coherence tomography

NASA Astrophysics Data System (ADS)

Armstrong, Julian J.; Leigh, Matthew S.; Walton, Ian D.; Zvyagin, Andrei V.; Alexandrov, Sergey A.; Schwer, Stefan; Sampson, David D.; Hillman, David R.; Eastwood, Peter R.

2003-07-01

We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

Hydrogeologic conditions and saline-water intrusion, Cape Coral, Florida, 1978-81

USGS Publications Warehouse

Fitzpatrick, D.J.

1986-01-01

The upper limestone unit of the intermediate aquifer system, locally called the upper Hawthorn aquifer, is the principal source of freshwater for Cape Coral, Florida. The aquifer has been contaminated with saline water by downward intrusion from the surficial aquifer system and by upward intrusion from the Floridan aquifer system. Much of the intrusion has occurred through open wellbores where steel casings are short or where casings have collapsed because of corrosion. Saline-water contamination of the upper limestone unit due to downward intrusion from the surficial aquifer is most severe in the southern and eastern parts of Cape Coral; contamination due to upward intrusion has occurred in many areas throughout Cape Coral. Intrusion is amplified in areas of heavy water withdrawals and large water-level declines. (USGS)

Upper Albian to Lower Turonian deposits and associated breccias along the Dahar cuestas (southeastern Tunisia): Origin and depositional environments

NASA Astrophysics Data System (ADS)

Krimi, Mabrouk; Ouaja, Mohamed; Zargouni, Fouad

2017-11-01

The carbonate Zebbag Formation of Upper Albian to Lower Turonian age which outcrops along the Dahar cuestas (south eastern Tunisia) includes several breccia intervals. The stratigraphic hierarchy of these breccia levels led to achieving a detailed sequential analysis within a spectrum of depositional environments extending from subtidal to inner to middle ramp settings. Six major transgressive/regressive sequences make up the stacking of the elementary sequences beginning with transgressive and/or storm wave breccias capped by desiccation and/or collapse breccias. The stratigraphic evolutionary history of the breccia facies are interpreted as the result of the interplay between eustatic and tectonic factors. This model is in accord with the tectonic activities common during Upper Albian-Lower Turonian responsible for the sequences onlapping.

Sedimentary response to ice stream advance and retreat on the Storfjorden Trough Mouth Fan (NW Barents Sea), during Late Weichselian

NASA Astrophysics Data System (ADS)

Pedrosa, Mayte; Camerlengui, Angelo; de Mol, Ben; Lucchi, Renata. G.; Úrgeles, Roger; Rebesco, Michele; Winsborrow, Monica; Laberg, Jan. S.; Andreassen, Karin; Accettella, Daniela

2010-05-01

This seafloor morphological study of the Storfjorden Trough Mouth Fan (TMF) (offshore Svalbard, NW Barents Sea) is based on new multibeam bathymetry and chirp sub-bottom profiler data acquired in 2007 during the BIO Hespérides cruise SVAIS that provides an unprecedented image of the sedimentary processes that accompanied the last advance and retreat of the Storfjorden Ice Stream. Compared to other glacial-marine sedimentary systems (such as the adjacent Bjørnøyrenna TMF), the Storfjorden TMF system is small and associated to a relatively small terrestrial ice sheet, approximately 40.000 km2, with local provenance from Svalbard and the Spitsbergen Bank. Due to this short distance from the ice source to the calving areas and the resulting short residence time of ice in the ice sheet, therefore the glacio -marine system of the Storfjorden reacts rapidly to climatic changes. The Storfjorden continental slope is characterized by three depositional lobes, produced by focused sedimentation at the terminus of ice streams that have changed their location with time. The superficial morphology features associated to the two northernmost lobes are straight gullies in the upper slope, and debris lobes starting from the midslope onwards. The seafloor expression of the southernmost lobe, adjacent to the much smaller Kveithola TMF, demonstrate almost no gully incisions and is dominated by the widespread occurrence of small-scale submarine landslides. The subbottom profiles illustrate that sediment failures occurred throughout the Late Neogene evolution of the southern Storfjorden and Kveithola margin, including large-scale mass transport deposits of up to 200 m thick. Seismic facies of the Neogene sequence shows an alternation of glacigenic debris flows and laminated sediment drape inferred to be plumites. Gullies incising glacigenic debris flows at the surface and subsurface and are filled by an interglacial drape sequence. The gullies are formed during each deglaciation phase, most likely by the erosive action of short-lived high density currents originated by sediment-loaded subglacial melt water discharge.At the outer continental shelf of the southernmost lobe a striking fresh linear straight, which has a width of 1, 5 kilometres and cut the morainal deposits. These features are interpreted as mega-scale glacial lineations, which are tentatively attributed to mega-iceberg scours. These lineations are witness the latest advances of the Storfjorden ice streams before the final retreat which was located at the southernmost lobe. One of the main pre-conditioning factors to slope instability on the southern part of the Storfjorden TMF is identified as high sedimentation rate plumites deposited on the middle-upper continental slope by glacial melt water plumes. This study is part of the SVAIS project (funded by the Spanish IPY), that has a main objective to improve the understanding and the relationship between sedimentation and ice sheet dynamics under natural climatic changes.

Is formation segregation melts in basaltic lava flows a viable analogue to melt generation in basaltic systems?

NASA Astrophysics Data System (ADS)

Thordarson, Thorvaldur; Sigmarsson, Olgeir; Hartley, Margaret E.; Miller, Jay

2010-05-01

Pahoehoe sheet lobes commonly exhibit a three-fold structural division into upper crust, core and lower crust, where the core corresponds to the liquid portion of an active lobe sealed by crust. Segregations are common in pahoehoe lavas and are confined to the core of individual lobes. Field relations and volume considerations indicate that segregation is initiated by generation of volatile-rich melt at or near the lower crust to core boundary via in-situ crystallization. Once buoyant, the segregated melt rises through the core during last stages of flow emplacement and accumulates at the base of the upper crust. The segregated melt is preserved as vesicular and aphyric, material within well-defined vesicle cylinders and horizontal vesicle sheets that make up 1-4% of the total lobe volume. We have undertaken a detailed sampling and chemical analysis of segregations and their host lava from three pahoehoe flow fields; two in Iceland and one in the Columbia River Basalt Group (CRBG). The Icelandic examples are: the olivine-tholeiite Thjorsa lava (24 cubic km) of the Bardarbunga-Veidivotn volcanic system and mildly alkalic Surtsey lavas (1.2 cubic km) of the Vestmannaeyjar volcanic system. The CRBG example is the tholeiitic ‘high-MgO group' Levering lava (>100? cubic km) of the N2 Grande Ronde Basalt. The thicknesses of the sampled lobes ranges from 2.3 to 14 m and each lobe feature well developed network of segregation structures [1,2,3]. Our whole-rock analyses show that the segregated melt is significantly more evolved than the host lava, with enrichment factors of 1.25 (Thjorsa) to 2.25 (Surtsey) for incompatible trace elements (Ba, Zr). Calculations indicate that the segregation melt was formed by 20 to 50% closed-system fractional crystallization of plagioclase (plus minor pyroxene and/or olivine). A more striking feature is the whole-rock composition of the segregations. In the olivine-tholeiite Thjorsa lava the segregations exhibit quartz tholeiite composition that is identical to the magma compositions produced by the nearby Grimsvotn and Kverkfjoll volcanic systems during the Holocene. The Surtsey segregations have whole-rock composition remarkably similar to the FeTi basalts from adjacent Katla volcanic system, whereas the segregations of the Levering flow are identical to the ‘low-MgO group' basalts of the CRBG. Is this a coincidence or does volatile induced liquid transfer, as inferred for the formation of the segregations, play an important role in magma differentiation in basaltic systems? [1]Thordarson & Self The Roza Member, Columbia River Basalt Group. J Geophys Res - Solid Earth [2] Sigmarsson, et al, 2009. Segregations in Surtsey lavas (Iceland). In Studies in Volcanology: The Legacy of George Walker. Special Publication of IAVCEI No 3. [3] Hartley & Thordarson, 2009, Melt segregations in a Columbia River Basalt lava flow. Lithos

Effect of Balloon Pulmonary Angioplasty on Respiratory Function in Patients With Chronic Thromboembolic Pulmonary Hypertension.

PubMed

Akizuki, Mina; Serizawa, Naoki; Ueno, Atsuko; Adachi, Taku; Hagiwara, Nobuhisa

2017-03-01

Balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) improves hemodynamics and exercise capacity. However, its effect on respiratory function is unclear. Our objective was to investigate the effect of BPA on respiratory function. We enrolled patients with inoperable CTEPH who underwent BPA primarily in lower lobe arteries (first series) and upper and middle lobe arteries (second series). We compared changes in hemodynamics and respiratory function between different BPA fields. Sixty-two BPA sessions were performed in 13 consecutive patients. Mean pulmonary arterial pressure and pulmonary vascular resistance significantly improved from 44 ± 8 to 23 ± 5 mm Hg and 818 ± 383 to 311 ± 117 dyne/s/cm -5 . The percent predicted diffusion capacity of lung for carbon monoxide (Dlco) decreased after BPA in the lower lung field (from 60% ± 8% to 54% ± 8%) with no recovery. Percent Dlco increased after BPA in the upper middle lung field (from 53% ± 6% to 58% ± 6%) and continued to improve during the follow-up (from 58% ± 6% to 64% ± 11%). The ventilation/Co 2 production (V˙e/V˙co 2 ) slope significantly improved after BPA in the lower lung field (from 51 ± 13 to 41 ± 8) and continued to improve during the follow-up (from 41 ± 8 to 35 ± 7); however, the V˙e/V˙co 2 slope remained unchanged after BPA in the upper/middle lung field. Changes in % Dlco and the V˙e/V˙co 2 slope differed significantly between lower and upper/middle lung fields. The effect of BPA on respiratory function in patients with CTEPH differed depending on the lung field. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Numerical tool development of fluid-structure interactions for investigation of obstructive sleep apnea

NASA Astrophysics Data System (ADS)

Huang, Chien-Jung; White, Susan; Huang, Shao-Ching; Mallya, Sanjay; Eldredge, Jeff

2016-11-01

Obstructive sleep apnea (OSA) is a medical condition characterized by repetitive partial or complete occlusion of the airway during sleep. The soft tissues in the upper airway of OSA patients are prone to collapse under the low pressure loads incurred during breathing. The ultimate goal of this research is the development of a versatile numerical tool for simulation of air-tissue interactions in the patient specific upper airway geometry. This tool is expected to capture several phenomena, including flow-induced vibration (snoring) and large deformations during airway collapse of the complex airway geometry in respiratory flow conditions. Here, we present our ongoing progress toward this goal. To avoid mesh regeneration, for flow model, a sharp-interface embedded boundary method is used on Cartesian grids for resolving the fluid-structure interface, while for the structural model, a cut-cell finite element method is used. Also, to properly resolve large displacements, non-linear elasticity model is used. The fluid and structure solvers are connected with the strongly coupled iterative algorithm. The parallel computation is achieved with the numerical library PETSc. Some two- and three- dimensional preliminary results are shown to demonstrate the ability of this tool.

Prevalence of tidal expiratory flow limitation in preschool children with and without respiratory symptoms: application of the negative expiratory pressure (NEP) method.

PubMed

JIRICKOVA, A; SULC, J; POHUNEK, P; KITTNAR, O; DOHNALOVA, A; KOFRANEK, J

2009-01-01

Negative expiratory pressure (NEP) applied at the mouth during tidal expiration provides a non-invasive method for detecting expiratory flow limitation. Forty-two children were studied, i.e. 25 children with different respiratory symptoms (R) and 17 without any respiratory symptoms (NR). Children were examined without any sedation. A preset NEP of -5 cm H(2)O was applied; its duration did not exceed duration of tidal expiration. A significance of FL was judged by determining of a flow-limited range (in % of tidal volume). FL was found in 48 % children of R group. No patient of the NR group elicited FL (P<0.001 R vs. NR). The frequency of upper airway collapses was higher in R group (12 children) than in NR group (5 children). In conclusion, a high frequency of tidal FL in the R group was found, while it was not present in NR group. A relatively high frequency of expiratory upper airway collapses was found in both groups, but it did not differ significantly. NEP method represents a reasonable approach for tidal flow limitation testing in non-sedated preschool children.

[Collagen-polyvinylpyrrolidone: a new therapeutic option for treatment of sequelae after radical mastectomy in women with breast cancer. Preliminary study].

PubMed

Ruiz-Eng, Rafael; Montiel-Jarquín, Alvaro; de la Rosa-Pérez, Raúl; López-Colombo, Aurelio; Gómez-Conde, Eduardo; Zamudio-Huerta, Leticia

2010-01-01

Approximately 30% of women who undergo mastectomy without reconstructive treatment due to breast cancer present sequelae. These include paresthesias, keloid healing, hypoesthesia, lymphedema and limitation of the function of the ipsilateral upper extremity. We undertook this study to present the results using collagen-polyvinylpyrrolidone (Clg- Pvp) as treatment for posmastectomy sequelae in women with breast cancer. We conducted a unicentric, longitudinal and prospective clinical trial between August 1, 2007 and July 31, 2008. Included variables were age, lymphedema, limitation of the function of the ipsilateral upper extremity, collapse of the wound, keloid healing, paresthesias, and appearance of the surgical area. The appearance of the surgical area (aesthetic aspect) was evaluated before and 6 months after treatment was initiated. Clg-Pvp was administered weekly for a 6-month period. Seven women were included with a median age of 49 years (range: 40-72 years). One patient (14.28%) presented lymphedema, two patients (28.57%) presented collapse of the wound, two patients (28.57%) had keloid healing, three patients (42.85%) experienced paresthesias, five patients (71.4%) reported pain, and five patients (71.4%) reported limitation of the function of the ipsilateral upper extremity. At the completion of the treatment, aesthetic improvement was statistically significant (p = 0.0020, Mann-Whitney U test). Clinical and aesthetic results are good after application of Clg-Pvp for treating sequelae in women with breast cancer who underwent mastectomy without reconstructive surgery.

Pulmonary cyst and cerebral arterial gas embolism in a hypobaric chamber: a case report.

PubMed

Cable, G G; Keeble, T; Wilson, G

2000-02-01

This is a report of an aircrew member who suffered a serious physiological incident in the form of pulmonary barotrauma and cerebral arterial gas embolism during hypobaric chamber training, and who subsequently was shown to have a cyst in the upper lobe of the left lung. The likely origin of the cyst is discussed, as well as the aeromedical disposition following thoracotomy and apical segmentectomy to remove the cyst.

Combined pulmonary fibrosis and emphysema: an increasingly recognized condition* **

PubMed Central

Dias, Olívia Meira; Baldi, Bruno Guedes; Costa, André Nathan; Carvalho, Carlos Roberto Ribeiro

2014-01-01

Combined pulmonary fibrosis and emphysema (CPFE) has been increasingly recognized in the literature. Patients with CPFE are usually heavy smokers or former smokers with concomitant lower lobe fibrosis and upper lobe emphysema on chest HRCT scans. They commonly present with severe breathlessness and low DLCO, despite spirometry showing relatively preserved lung volumes. Moderate to severe pulmonary arterial hypertension is common in such patients, who are also at an increased risk of developing lung cancer. Unfortunately, there is currently no effective treatment for CPFE. In this review, we discuss the current knowledge of the pathogenesis, clinical characteristics, and prognostic factors of CPFE. Given that most of the published data on CPFE are based on retrospective analysis, more studies are needed in order to address the role of emphysema and its subtypes; the progression of fibrosis/emphysema and its correlation with inflammation; treatment options; and prognosis. PMID:25029654

Lipoid proteinosis: A case with distinct histopathological and radiological findings.

PubMed

Brar, Balvinder Kaur; Jain, Sarina; Brar, Sukhmani Kaur

2017-10-01

Lipoid proteinosis is a rare inherited genodermatosis characterized by hyaline deposits in various tissues. Clinically, it manifests with cutaneous as well as extracutaneous features. Periodic acid-Schiff (PAS)-reactive hyaline deposits in the upper dermis, with localization around blood vessels and eccrine sweat glands, in particular, is the histopathological hallmark finding. On brain imaging, bilateral symmetrical temporal lobe calcifications are considered to be pathognomonic of this disorder. We report a case of lipoid proteinosis in which hyaline deposits were present in the papillary and reticular dermis, without being seen at the periphery of eccrine sweat glands, along with dystrophic calcification. Magnetic resonance imaging (MRI) of brain revealed hydrocephalus, subependymal heterotropia and absent splenium of corpus callosum with no evidence of temporal lobe calcification. Thus, our case highlights the inherent diverse nature of lipoid proteinosis. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Hyperplasia of type 2 pneumocytes following 0. 34 ppm nitrogen dioxide exposure: quantitation by image analysis. [Mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sherwin, R.P.; Richters, V.

1982-09-01

Swiss Webster male mice were exposed to intermittent 0.34 ppm nitrogen dioxide for 6 wk. Quantitative image analysis showed increased Type 2 cell numbers in each of the three lobes measured, with and without adjustment to alveolar wall measurements for lung volume normalization (e.g., P < .037 for Type 2 cell number adjusted to alveolar wall perimeters, combined lobe analysis of variance). The exposed animals dominated the upper quartile ranking of the cell number/alveolar area ratio computations (P < .025), which implied the presence of an especially susceptible subpopulation of animals. The Type 2 cell increase is believed to resultmore » from damage and loss of Type 1 cells, the reversibility and progression of which are presently unknown. The data also suggest an increased size of the Type 2 cell, and possibly slight atelectasis and/or edema of the alveolar walls.« less

Overview of the magnetic signatures of the Palaeoproterozoic Rustenburg Layered Suite, Bushveld Complex, South Africa

USGS Publications Warehouse

Cole, Janine; Finn, Carol A.; Webb, Susan J.

2013-01-01

Aeromagnetic data clearly delineate the mafic rocks of the economically significant Bushveld Igneous Complex. This is mainly due to the abundance of magnetite in the Upper Zone of the Rustenburg Layered Suite of the Bushveld, but strongly remanently magnetised rocks in the Main Zone also contribute significantly in places. In addition to delineating the extent of the magnetic rocks in the complex, the magnetic anomalies also provide information about the dip and depth of these units. The presence of varying degrees of remanent magnetisation in most of the magnetic lithologies of the Rustenburg Layered Suite complicates the interpretation of the data. The combination of available regional and high resolution airborne magnetic data with published palaeomagnetic data reveals characteristic magnetic signatures associated with the different magnetic lithologies in the Rustenburg Layered Suite. As expected, the ferrogabbros of the Upper Zone cause the highest amplitude magnetic anomalies, but in places subtle features within the Main Zone can also be detected. A marker with strong remanent magnetisation located in the Main Zone close to the contact with the Upper Zone is responsible for very high amplitude negative anomalies in the southern parts of both the eastern and western lobes of the Bushveld Complex. Prominent anomalies are not necessarily related to a specific lithology, but can result from the interaction between anomalies caused by differently magnetised bodies.The magnetic data provided substantial information at different levels of detail, ranging from contacts between zones, and layering within zones, to magnetite pipes dykes and faults that can have an impact on mine planning. Finally, simple modelling of the magnetic data supports the concept of continuous mafic rocks between the western and eastern lobes.

National Emphysema Treatment Trial redux: accentuating the positive.

PubMed

Sanchez, Pablo Gerardo; Kucharczuk, John Charles; Su, Stacey; Kaiser, Larry Robert; Cooper, Joel David

2010-09-01

Under the Freedom of Information Act, we obtained the follow-up data of the National Emphysema Treatment Trial (NETT) to determine the long-term outcome for "a heterogeneous distribution of emphysema with upper lobe predominance," postulated by the NETT hypothesis to be optimal candidates for lung volume reduction surgery. Using the NETT database, we identified patients with heterogeneous distribution of emphysema with upper lobe predominance and analyzed for the first time follow-up data for those receiving lung volume reduction surgery and those receiving medical management. Furthermore, we compared the results of the NETT reduction surgery group with a previously reported consecutive case series of 250 patients undergoing bilateral lung volume reduction surgery using similar selection criteria. Of the 1218 patients enrolled, 511 (42%) conformed to the NETT hypothesis selection criteria and received the randomly assigned surgical or medical treatment (surgical = 261; medical = 250). Lung volume reduction surgery resulted in a 5-year survival benefit (70% vs 60%; P = .02). Results at 3 years compared with baseline data favored surgical reduction in terms of residual volume reduction (25% vs 2%; P < .001), University of California San Diego dyspnea score (16 vs 0 points; P < .001), and improved St George Respiratory Questionnaire quality of life score (12 points vs 0 points; P < .001). For the 513 patients with a homogeneous pattern of emphysema randomized to surgical or medical treatment, lung volume reduction surgery produced no survival advantage and very limited functional benefit. Patients most likely to benefit from lung volume reduction surgery have heterogeneously distributed emphysema involving the upper lung zones predominantly. Such patients in the NETT trial had results nearly identical to those previously reported in a nonrandomized series of similar patients undergoing lung volume reduction surgery. 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

Anatomical variations of the thymus in relation to the left brachiocephalic vein, findings of necropsia.

PubMed

Plaza, Oscar Alonso; Moreno, Freddy

2018-04-01

Two cases of anatomical variations of the thymus are presented with respect to the anatomical relations with the left brachiocephalic vein and found during the necropsy process. Less than 2 days after birth with Noonan Syndrome, when the left brachiocephalic vein was scanning behind the upper thymus horns, there were other adjacent lesions consisting of three supernumerary spleens and three hepatic veins. The second case was an 8-year-old infant with child malpractice who died from urinary sepsis due to obstructive uropathy, in which case the upper lobes of the thymus were fused and formed a ring through which the left brachiocephalic vein passed. Copyright © 2018 Elsevier B.V. All rights reserved.

Salt tectonics in an experimental turbiditic tank

NASA Astrophysics Data System (ADS)

Sellier, Nicolas; Vendeville, Bruno

2010-05-01

We modelled the effect of the deposition of clastic sediments wedges along passive margin by combining two different experimental approaches. The first approach, which uses flume experiments in order to model turbiditic transport and deposition, had focused, so far mainly on the stratigraphic architecture and flow properties. But most experiments have not accounted for the impact of syndepositional deformation. The second approach is the classic tectonic modelling (sand-box experiments) is aimed essentially at understanding deformation, for example the deformation of a sediment wedge deposited onto a mobile salt layer. However, with this approach, the sediment transport processes are crudely modelled by adding each sediment layer uniformly, regardless of the potential influence of the sea-floor bathymetry on the depositional pattern. We designed a new tectono-stratigraphic modelling tank, which combines modelling of the turbiditic transport and deposition, and salt-related deformation driven by sediment loading. The set-up comprises a channel connected to a main water tank. A deformation box is placed at the mouth of the channel, on the base of the tank. The base of the box can be filled with various kinds of substrates either rigid (sand) or viscous (silicone polymer, simulating mobile salt layer having varying length and thickness). A mixture of fine-grained powder and water is maintained in suspension in a container, and then released and channelled toward the basin, generating an analogue of basin-floor fans or lobes. We investigated the effect of depositing several consecutive turbiditic lobes on the deformation of the salt body and its overburden. The dynamics of experimental turbidity currents lead to deposits whose thickness varied gradually laterally: the lobe is thick in the proximal region and thins progressively distally, thus creating a very gentle regional surface slope. As the fan grows by episodic deposition of successive turbiditic lobes, the model deforms spontaneously by vertical collapse and lateral spreading of the entire overburden. We conducted a series of systematic experiments varying the length and thickness of the salt body, as well as the sediment input and nature.

Effects of Lung Volume Reduction Surgery on Gas Exchange and Breathing Pattern During Maximum Exercise

PubMed Central

Criner, Gerard J.; Belt, Patricia; Sternberg, Alice L.; Mosenifar, Zab; Make, Barry J.; Utz, James P.; Sciurba, Frank

2009-01-01

Background: The National Emphysema Treatment Trial studied lung volume reduction surgery (LVRS) for its effects on gas exchange, breathing pattern, and dyspnea during exercise in severe emphysema. Methods: Exercise testing was performed at baseline, and 6, 12, and 24 months. Minute ventilation (V̇e), tidal volume (Vt), carbon dioxide output (V̇co2), dyspnea rating, and workload were recorded at rest, 3 min of unloaded pedaling, and maximum exercise. Pao2, Paco2, pH, fraction of expired carbon dioxide, and bicarbonate were also collected in some subjects at these time points and each minute of testing. There were 1,218 patients enrolled in the study (mean [± SD] age, 66.6 ± 6.1 years; mean, 61%; mean FEV1, 0.77 ± 0.24 L), with 238 patients participating in this substudy (mean age, 66.1 ± 6.8 years; mean, 67%; mean FEV1, 0.78 ± 0.25 L). Results: At 6 months, LVRS patients had higher maximum V̇e (32.8 vs 29.6 L/min, respectively; p = 0.001), V̇co2, (0.923 vs 0.820 L/min, respectively; p = 0.0003), Vt (1.18 vs 1.07 L, respectively; p = 0.001), heart rate (124 vs 121 beats/min, respectively; p = 0.02), and workload (49.3 vs 45.1 W, respectively; p = 0.04), but less breathlessness (as measured by Borg dyspnea scale score) [4.4 vs 5.2, respectively; p = 0.0001] and exercise ventilatory limitation (49.5% vs 71.9%, respectively; p = 0.001) than medical patients. LVRS patients with upper-lobe emphysema showed a downward shift in Paco2 vs V̇co2 (p = 0.001). During exercise, LVRS patients breathed slower and deeper at 6 months (p = 0.01) and 12 months (p = 0.006), with reduced dead space at 6 months (p = 0.007) and 24 months (p = 0.006). Twelve months after patients underwent LVRS, dyspnea was less in patients with upper-lobe emphysema (p = 0.001) and non–upper-lobe emphysema (p = 0.007). Conclusion: During exercise following LVRS, patients with severe emphysema improve carbon dioxide elimination and dead space, breathe slower and deeper, and report less dyspnea. PMID:19420196

Genome-Wide Study of Percent Emphysema on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study

PubMed Central

Manichaikul, Ani; Hoffman, Eric A.; Smolonska, Joanna; Gao, Wei; Cho, Michael H.; Baumhauer, Heather; Budoff, Matthew; Austin, John H. M.; Washko, George R.; Carr, J. Jeffrey; Kaufman, Joel D.; Pottinger, Tess; Powell, Charles A.; Wijmenga, Cisca; Zanen, Pieter; Groen, Harry J. M.; Postma, Dirkje S.; Wanner, Adam; Rouhani, Farshid N.; Brantly, Mark L.; Powell, Rhea; Smith, Benjamin M.; Rabinowitz, Dan; Raffel, Leslie J.; Hinckley Stukovsky, Karen D.; Crapo, James D.; Beaty, Terri H.; Hokanson, John E.; Silverman, Edwin K.; Dupuis, Josée; O’Connor, George T.; Boezen, H. Marike; Rich, Stephen S.

2014-01-01

Rationale: Pulmonary emphysema overlaps partially with spirometrically defined chronic obstructive pulmonary disease and is heritable, with moderately high familial clustering. Objectives: To complete a genome-wide association study (GWAS) for the percentage of emphysema-like lung on computed tomography in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung/SNP Health Association Resource (SHARe) Study, a large, population-based cohort in the United States. Methods: We determined percent emphysema and upper-lower lobe ratio in emphysema defined by lung regions less than −950 HU on cardiac scans. Genetic analyses were reported combined across four race/ethnic groups: non-Hispanic white (n = 2,587), African American (n = 2,510), Hispanic (n = 2,113), and Chinese (n = 704) and stratified by race and ethnicity. Measurements and Main Results: Among 7,914 participants, we identified regions at genome-wide significance for percent emphysema in or near SNRPF (rs7957346; P = 2.2 × 10−8) and PPT2 (rs10947233; P = 3.2 × 10−8), both of which replicated in an additional 6,023 individuals of European ancestry. Both single-nucleotide polymorphisms were previously implicated as genes influencing lung function, and analyses including lung function revealed independent associations for percent emphysema. Among Hispanics, we identified a genetic locus for upper-lower lobe ratio near the α-mannosidase–related gene MAN2B1 (rs10411619; P = 1.1 × 10−9; minor allele frequency [MAF], 4.4%). Among Chinese, we identified single-nucleotide polymorphisms associated with upper-lower lobe ratio near DHX15 (rs7698250; P = 1.8 × 10−10; MAF, 2.7%) and MGAT5B (rs7221059; P = 2.7 × 10−8; MAF, 2.6%), which acts on α-linked mannose. Among African Americans, a locus near a third α-mannosidase–related gene, MAN1C1 (rs12130495; P = 9.9 × 10−6; MAF, 13.3%) was associated with percent emphysema. Conclusions: Our results suggest that some genes previously identified as influencing lung function are independently associated with emphysema rather than lung function, and that genes related to α-mannosidase may influence risk of emphysema. PMID:24383474

Adult obstructive sleep apnoea

PubMed Central

Jordan, Amy S.; McSharry, David G.; Malhotra, Atul

2013-01-01

Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway collapse during sleep, which leads to oxygen desaturation and disrupted sleep. Symptoms include snoring, witnessed apnoeas, and sleepiness. Pathogenesis varies; predisposing factors include small upper airway lumen, unstable respiratory control, low arousal threshold, small lung volume, and dysfunctional upper airway dilator muscles. Risk factors include obesity, male sex, age, menopause, fluid retention, adenotonsillar hypertrophy, and smoking. Obstructive sleep apnoea causes sleepiness, road traffic accidents, and probably systemic hypertension. It has also been linked to myocardial infarction, congestive heart failure, stroke, and diabetes mellitus though not definitively. Continuous positive airway pressure is the treatment of choice, with adherence of 60–70%. Bi-level positive airway pressure or adaptive servo-ventilation can be used for patients who are intolerant to continuous positive airway pressure. Other treatments include dental devices, surgery, and weight loss. PMID:23910433

TOP VIEW OF UPPER TRAM TERMINAL, PRIMARY ORE BIN, AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

TOP VIEW OF UPPER TRAM TERMINAL, PRIMARY ORE BIN, AND ORE CHUTE,LOOKING SOUTHWEST. TRAM MACHINERY AND GEARS ARE AT LOWER CENTER. A SMALL ELECTRIC MOTOR AT THE REAR LEFT OF THE TERMINAL PROBABLY WAS ADDED AFTER THE ORIGINAL CONSTRUCTION. THE MOVING CABLE OF THE TRAM WAS DRIVEN BY THESE GEARS AND THE LARGE WHEEL UNDERNEATH (SEE CA-291-31 FOR DETAIL). EMPTY TRAM BUCKETS CAME IN FROM THE LEFT, SWINGING AROUND TO THE CHUTES FROM THE ORE BIN TO BE LOADED FOR THE TRIP DOWN TO THE MILL (SEE CA-291-35 FOR DETAIL). THE BREAK OVER TOWER CAN BE SEEN IN THE DISTANCE AT TOP LEFT. THE SUPPORT TOWER BETWEEN THE UPPER TERMINAL AND THE BREAK OVER TOWER IS COLLAPSED. - Keane Wonder Mine, Park Route 4 (Daylight Pass Cutoff), Death Valley Junction, Inyo County, CA

Gross morphology and ultrastructure of salivary glands of the mute cicada Karenia caelatata Distant (Hemiptera: Cicadoidea).

PubMed

Zhong, Hai-ying; Wei, Cong; Zhang, Ya-lin

2013-02-01

Salivary glands of the cicada Karenia caelatata Distant were investigated using light microscopy and transmission electron microscopy. The salivary glands are paired structures and consist of principal glands and accessory glands. The principal gland is subdivided into anterior lobe and posterior lobe; the former contains about 34-39 long digitate lobules, while the latter contains approximately 30-33 long digitate lobules and 13-22 short digitate lobules. These short digitate lobules, about one fifth or sixth as long as the long digitate lobules, locate at the base of the long digitate lobules of posterior lobe. All of these digitate lobules vary in size, disposition, length and shape. The anterior lobe and the posterior lobe are connected by an anterior-posterior duct. Two efferent salivary ducts, which connect with the posterior lobe, fuse to form a common duct. The accessory gland is composed of three parts: a greatly tortuous and folded accessory salivary tube, a circlet of gular gland constituting of several acini of the same size, and a non-collapsible accessory salivary duct. The digitate lobules and gular glands possess secretory cells containing abundant secretory granules vary in size, shape, and electron density, as might indicate different materials are synthesized in different secretory regions. The anterior-posterior duct lines with a player of cuticular lining, and cells beneath the cuticular lining lack of basal infoldings, as suggests the duct serves just to transport secretions. The accessory salivary duct is lined with cuticular lining; cells of the duct have well developed basal infoldings associated with abundant mitochondria, as probably suggests the duct is a reabsorptive region of ions. The cells of the accessory salivary tube possess deep basal infoldings and well developed apical dense microvilli, indicating the cells of the tube are secretory in function. Concentric lamellar structures and a peculiar structure with abundant membrane-bound vesicles and secretory granules are observed for the first time, but their derivation and function remain unclear. The morphology and ultrastructure differences observed in the principal glands and accessory gland of the salivary glands of K. caelatata indicate that the sheath saliva was secreted by the principal glands, and the watery saliva was secreted by the accessory salivary glands. Rod-shaped microorganisms are found in the salivary glands (i.e., accessory salivary duct, gular gland, and long digitate lobule of salivary glands) for the first time, and their identity, function, and relationship to microorganisms residing in the salivary glands and/or other parts of alimentary canal of other cicadas need to be investigated further. Copyright © 2012 Elsevier Ltd. All rights reserved.

Increase of Coastal Cliff Rockfall Trigerred By Rainfall On The Chalk Coast of NW France During The Year 2001

NASA Astrophysics Data System (ADS)

Duperret, A.; Genter, A.; Daigneault, M.; Mortimore, R. N.

Coastal chalk cliffs exposed on each part of the English Channel suffer numerous collapses, with mean volumes varying between 10 000 and 100 000 cubic meters. Between October 1998 and October 2001, a minimum of 52 collapses have been ob- served along 120 km of the French chalk coastline located in Upper-Normandy and Picardy. The chalk coastline has evidenced 4 collapses in 1999 and 6 collapses in 2000 (winter and spring), whereas 28 collapses with volume greater than 1000 m3 was recorded in 2001 (winter, spring and summer). The increase of large-scale collapses during 2001 is interpreted as an excess of rainfalls recorded previously. Most of these collapses extend all over the vertical cliff height and are mainly controlled by ground- water infiltration. The modality of water circulation through the chalk rock depends on the chalk lithology and the hydrogeological properties of pre-existing fractures. In the framework of the European scientific project named ROCC (Risk of Cliff Col- lapse), the chalk lithology and the pre-existing fracture pattern have been investigated in order to determine the response of the rock mass to subaerial and marine solicita- tions, including rainfall conditions. Such data have been reported in a GIS system in order to determine the degree of cliff sensibility to collapses. Some rainfall-triggered collapses will be presented to illustrate the diversity of the rock mass response to rain- fall excess, in terms of rock mass characteristics and time delay: (1) a collapse was witnessed at Puys, the 17th May 2000, after two periods of intense rainfall inducing floods, during the two previous months. The occurrence of impervious marl seams levels within the chalk and its low fracture content may have generated water over- pressure and consequently stress concentration on the marl seams, which conduct to the rupture. The delay between rainfall and the rupture may be explained by the low velocity of groundwater through a poorly fractured porous chalk. (2) a series of large- scale collapses has been evidenced at Yport in June 2001, at Grandes Dalles the 15th July 2001 and at Benouville the 24th July 2001. These collapses occurred after a dry period, during the previous three months. A collapse occurred again at Yport the 27th August 2001, after an increase of rainfall during August 2001. All these sites present the same lithological chalk succession than at Puys, but their fracture pattern is made of large-scale subvertical fractures expanding all over the cliff height. Some of them 1 which correspond to dissolution pipes are filled with clays-with-flints. The sharp in- crease of collapses during the summer 2001 could be related to the superimposition of dry periods which alternate with heavy rainfalls, in karst environment. 2

A Right Upper Lobe Mass in the Thorax After Modified Blalock-Taussig Shunt.

PubMed

Manuel, Valdano; Miguel, Gade; Magalhães, Manuel Pedro; Nunes, Maria Ana; Morais, Humberto; Júnior, António Filipe

2016-07-01

We report an incidental finding of pseudoaneurysm in a 10-month-old boy with tetralogy of Fallot and Down syndrome who had undergone placement of a modified Blalock-Taussig shunt at age four months. Computed tomography was a determinant exam for better assessment. The lesion was successfully resected with concomitant complete repair of tetralogy of Fallot in a single-stage. The child was asymptomatic at fourth month follow-up. © The Author(s) 2016.

Cold-seep-like macrofaunal communities in organic- and sulfide-rich sediments of the Congo deep-sea fan

NASA Astrophysics Data System (ADS)

Olu, K.; Decker, C.; Pastor, L.; Caprais, J.-C.; Khripounoff, A.; Morineaux, M.; Ain Baziz, M.; Menot, L.; Rabouille, C.

2017-08-01

Methane-rich fluids arising from organic matter diagenesis in deep sediment layers sustain chemosynthesis-based ecosystems along continental margins. This type of cold seep develops on pockmarks along the Congo margin, where fluids migrate from deep-buried paleo-channels of the Congo River, acting as reservoirs. Similar ecosystems based on shallow methane production occur in the terminal lobes of the present-day Congo deep-sea fan, which is supplied by huge quantities of primarily terrestrial material carried by turbiditic currents along the 800 km channel, and deposited at depths of up to nearly 5000 m. In this paper, we explore the effect of this carbon enrichment of deep-sea sediments on benthic macrofauna, along the prograding lobes fed by the current active channel, and on older lobes receiving less turbiditic inputs. Macrofaunal communities were sampled using either USNEL cores on the channel levees, or ROV blade cores in the chemosynthesis-based habitats patchily distributed in the active lobe complex. The exceptionally high organic content of the surface sediment in the active lobe complex was correlated with unusual densities of macrofauna for this depth, enhanced by a factor 7-8, compared with those of the older, abandoned lobe, whose sediment carbon content is still higher than in Angola Basin at same depth. Macrofaunal communities, dominated by cossurid polychaetes and tanaids were also more closely related to those colonizing low-flow cold seeps than those of typical deep-sea sediment. In reduced sediments, microbial mats and vesicomyid bivalve beds displayed macrofaunal community patterns that were similar to their cold-seep counterparts, with high densities, low diversity and dominance of sulfide-tolerant polychaetes and gastropods in the most sulfidic habitats. In addition, diversity was higher in vesicomyid bivalve beds, which appeared to bio-irrigate the upper sediment layers. High beta-diversity is underscored by the variability of geochemical gradients in vesicomyid assemblages, and by the vesicomyid population characteristics that vary in density, size and composition. By modifying the sediment geochemistry differently according to their morphology and physiology, the different vesicomyid species play an important role structuring macrofauna composition and vertical distribution. Dynamics of turbiditic deposits at a longer temporal scale (thousands of years) and their spatial distribution in the lobe area also resulted in high heterogeneity of the "cold-seep-like communities". Dynamics of chemosynthetic habitats and associated macrofauna in the active lobe area resembled those previously observed at the Regab pockmark along the Congo margin and rapid succession is expected to cope with high physical disturbance by frequent turbiditic events and huge sedimentation rates. Finally, we propose a model of the temporal evolution of these peculiar habitats and communities on longer timescales in response to changes in distributary channels within the lobe complex.

Structural analysis of Nalagarh lobe, NW Himalaya: implication of thrusting across tectonic edge of NW limb of Nahan salient, Himachal Pradesh, India

NASA Astrophysics Data System (ADS)

Bhakuni, S. S.; Philip, G.; Suresh, N.

2017-07-01

The Main Boundary Fault (MBF), convex towards southwest, forms the leading edge of the Nahan salient. Near the southern end of an oblique ramp, a lobe-shaped physiographic front, named in this work as Nalagarh lobe, has developed across NW limb of salient. The lobe has formed across the MBF that separates the hanging wall Lower Tertiary Dharmsala rocks from the footwall Upper Tertiary Siwalik rocks and overlying Quaternaries. In front of lobe, thrust fault splays (Splay-1 and Splay-2) and associated tectonic fabrics have developed within the Late Pleistocene fan deposit. Structural elements developed across the front of Nalagarh lobe are analysed with reference to evolution of lobe. An unweathered 15-m-high hanging wall or wedge top forms the uplifted and rejuvenated bedrock fault scarp of the MBF. Below the MBF, the fan deposit has underthrust along Splay-1. Later the Splay-2 formed within fan deposit near south of Splay-1. Geometry of the overturned limb of tight to isoclinal fault propagation fold, formed on Splay-2 plane, suggests that the fold formed by normal drag, produced by intermittent fault-slips along Splay-2. The displacement along Splay-2 offset the marker bed to 1 m by which some clasts rotated parallel to the traces of brittle axial planes of fold. The variable fold geometry and style of deformation are analysed along length of thrust splays for 5 km. It is revealed that the lobe is bounded by transverse thrust faults along its NW and SE margins. The geometry of salient and oblique ramp suggests that the transverse thrust faults and associated transverse folds formed by right-lateral displacement along the NW limb of the salient. Marking the northern margin of the intermontane piggyback basin of Pinjaur dun, the MBF is interpreted to be an out-of-sequence thrust that has brought up the Lower Tertiary Dharmsala rocks over the Late Pleistocene fan deposit. The geometry of lobe and its bounding transverse faults suggest that faults are intimately associated with the kinematics of the transition between the Nahan salient and Kangra recess. The transition is a transfer zone forming a long pre-Himalayan lineament across which the stratigraphic set of the Tethys and Lesser Himalaya is different. The study suggests that the lateral ramp on the Main Himalayan Thrust does not exist beneath the apex and also beneath the SE limb of the salient in the Sub-Himalayan region. This ramp should be present only beneath near end point of SW limb of the Nahan salient.

Himalayan Sackung and Associations to Regional Structure

NASA Astrophysics Data System (ADS)

Shroder, J. F.; Bishop, M. P.; Olsenholler, J.

2003-12-01

Recognition of sackung slope failure or deep-seated, rock-slope deformation in the Himalaya has been rather limited, in part because: (1) many geoscientists do not recognize its characteristics; (2) large-scale aerial photographs and topographic maps used to identify the characteristic surficial, topographic manifestations of the failure type are commonly low-level state secrets in that region; and (3) no systematic survey for sackung has ever been made in the Himalaya. In the Pakistani-controlled, western Himalaya, some unconventional access to aerial photographs in the Kaghan and Nanga Parbat areas allowed first recognition of several characteristic ridge-top grabens and anti-slope scarps. Later release of declassified, stereo imagery from the CORONA and KEYHOLE satellite series enabled discovery of other examples in the K2 region. Comparison of mapped sackung failures with geologic base maps has demonstrated some coincidence of sackung with various structural trends, including synformal structures in upper thrust plates or along the traces of high-angle faults. In all probability these structural trends have provided plentiful ancillary planes of weakness along which gravitationally driven sackung is facilitated. Sackung failure in the Himalaya appears to be a spatially scale-dependent manifestation of a gravitational-collapse continuum of the brittle, upper crust, mainly involving mountain ridges. In contrast, gravitational collapse of the whole range may involve some similar failures but also include listric faulting, as well as subsidence movement into zones of ductility at depth. Temporal scale dependence of sackung may also be threshold dominated, wherein initial long-continued, slow failure ultimately leads to the commonly catastrophic rock-slope collapses recently recognized throughout the western Himalaya and now differentiated from their original mismapping as glacial moraines. Such sackung in Himalayan terrain undergoing active deglaciation from global warming may increase catastrophic slope-failure hazard.

Products of Submarine Fountains and Bubble-burst Eruptive Activity at 1200 m on West Mata Volcano, Lau Basin

NASA Astrophysics Data System (ADS)

Clague, D. A.; Rubin, K. H.; Keller, N. S.

2009-12-01

An eruption was observed and sampled at West Mata Volcano using ROV JASON II for 5 days in May 2009 during the NSF-NOAA eruption response cruise to this region of suspected volcanic activity. Activity was focused near the summit at the Prometheus and Hades vents. Prometheus erupted almost exclusively as low-level fountains. Activity at Hades cycled between vigorous degassing, low fountains, and bubble-bursts, building up and partially collapsing a small spatter/scoria cone and feeding short sheet-like and pillow flows. Fire fountains at Prometheus produced mostly small primary pyroclasts that include Pele's hair and fluidal fragments of highly vesicular volcanic glass. These fragments have mostly shattered and broken surfaces, although smooth spatter-like surfaces also occur. As activity wanes, glow in the vent fades, and denser, sometimes altered volcanic clasts are incorporated into the eruption. The latter are likely from the conduit walls and/or vent-rim ejecta, drawn back into the vent by inrushing seawater that replaces water entrained in the rising volcanic plume. Repeated recycling of previously erupted materials eventually produces rounded clasts resembling beach cobbles and pitted surfaces on broken phenocrysts of pyroxene and olivine. We estimate that roughly 33% of near vent ejecta are recycled. Our best sample of this ejecta type was deposited in the drawer of the JASON II ROV during a particularly large explosion that occurred during plume sampling immediately above the vent. Elemental sulfur spherules up to 5 mm in diameter are common in ejecta from both vents and occur inside some of the lava fragments Hades activity included dramatic bubble-bursts unlike anything previously observed under water. The lava bubbles, sometimes occurring in rapid-fire sequence, collapsed in the water-column, producing fragments that are quenched in less than a second to form Pele's hair, limu o Pele, spatter-like lava blobs, and scoria. All are highly vesicular, including the hairs and limu, unlike similar fragments from Loihi Seamount, Axial Seamount, and mid-ocean ridges that have <10% vesicles. The lava bubbles were observed to reach about 1 m in diameter, sometimes appearing to separate from the lava surface, suggesting that they are fed by gasses rising directly from the conduit. Slow-motion video analysis shows that the lava skin stretches to form thin regions that then separate, exposing still incandescent gas within. Bubbles collapse as the lava skin disrupts (usually at the top of the bubble), producing a shower of convex spatter-like lava fragments. Sheet-like lava flows are associated with collapse of the spatter cone and change to pillow lobe extrusion about 5 m from the vent orifice. One pillow lobe sample collected molten contains ~60% vesicles. We suggest that the erupting melt contains large coalesced slugs of magmatic gas and abundant small expanding vesicles that have yet to be incorporated into the large gas slugs. The contrast with Prometheus suggests highly localized conditions of magma devolatilization at W. Mata.

High-resolution T2-weighted abdominal magnetic resonance imaging using respiratory triggering: impact of butylscopolamine on image quality.

PubMed

Wagner, M; Klessen, C; Rief, M; Elgeti, T; Taupitz, M; Hamm, B; Asbach, P

2008-05-01

Respiratory triggering allows the acquisition of high-resolution magnetic resonance (MR) images of the upper abdomen. However, the depiction of organs close to the gastrointestinal tract can be considerably impaired by ghosting artifacts and blurring caused by bowel peristalsis. To evaluate the effect of gastrointestinal motion suppression by intramuscular butylscopolamine administration on the image quality of a respiratory-triggered T2-weighted turbo spin-echo (T2w TSE) sequence of the upper abdomen. Images of 46 patients were retrospectively analyzed. Twenty-four patients had received intramuscular injection of 40 mg butylscopolamine immediately before MR imaging. Fourteen of the 24 patients in the butylscopolamine group underwent repeat imaging after a mean of 29 min. Quantitative analysis of the ghosting artifacts was done by measuring signal intensities in regions of interest placed in air anterior to the patient. In addition, image quality was assessed qualitatively by two radiologists by consensus. Spasmolytic medication with butylscopolamine reduced ghosting artifacts and significantly improved image quality of the respiratory-triggered T2w TSE sequence. The most pronounced effect of butylscopolamine administration on image quality was found for the pancreas and the left hepatic lobe. The rate of examinations with excellent or good depiction of the pancreas and the left hepatic lobe in the group without premedication and in the butylscopolamine group was 55% vs. 96% (pancreatic head), 35% vs. 88% (pancreatic body), 43% vs. 96% (pancreatic tail), and 45% vs. 83% (left hepatic lobe), respectively. Regarding the duration of the effect of intramuscular butylscopolamine, repeat imaging after a mean of 29 min did not result in a significant deterioration of image quality. Intramuscular butylscopolamine administration significantly improves image quality of respiratory-triggered T2-weighted abdominal MR imaging by persistent reduction of peristaltic artifacts. MR imaging of the liver and pancreas in particular benefits from the suppression of gastrointestinal peristalsis by butylscopolamine.

Depostional systems, provenance, and sequence stratigraphy, Carter and [open quotes]Millerella[close quotes] sandstones of northeast Mississippi

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cleaves, A.W. II

1993-09-01

The subsurface [open quotes]Millerella[close quotes] and Carter sandstones (middle Chesterian) of the Black Warrior basin represent the highest units of the thick Muldon clastics deltaic facies tract. Lowstand marine conditions during Carter deposition allowed for southeastwardly progradation of five distinct deltaic lobe complexes onto the stable northern shelf of the basin. With each of these lobes, both an [open quotes]A[close quotes] (upper) and a [open quotes]B[close quotes] (lower) reservoir unit can be identified. The [open quotes]B[close quotes] sandstone produces from delta-front sheet sands, channel-mouth bars, and possible bar fingers of river-dominated deltas. The more prolific [open quotes]A[close quotes] subdivision containsmore » reservoirs in upper delta-plain point bars, crevasse splays, and distributary channel fills. The most easterly of the lobes, preserved in the Bean's Ferry field of Itawamba County, comprises an amalgamated valley-fill facies that removed a maximum of 250 ft (76 m) of lower Bangor platform carbonates. In contrast, the [open quotes]Millerella[close quotes] sandstone is a series of unconnected pods that formed as marine-reworked sand bodies during a eustatic rise in sea level. The average detrital sand grain composition for four cores taken in Monroe County is 94.7% monocrystalline quartz, 2.9% polycrystalline quartz, 1.6% albite feldspar, 0.1% low-rank metamorphic rock fragments, 0.5 chert, and 0.2% muscovite. These data indicate that neither the Ozark uplift nor the Ouachita orogen could have acted as the principal source area for the Carter and [open quotes]Millerella[close quotes] sandstones. More likely, the sedimentary-igneous terrains along the northern margin of the Illinois basin served this function. A major eustatic lowstand brought this mineralogically mature sediment across the Illinois basin through incised valleys to the northern self of the Black Warrior basin.« less

Ontogeny of head and caudal fin shape of an apex marine predator: The tiger shark (Galeocerdo cuvier).

PubMed

Fu, Amy L; Hammerschlag, Neil; Lauder, George V; Wilga, Cheryl D; Kuo, Chi-Yun; Irschick, Duncan J

2016-05-01

How morphology changes with size can have profound effects on the life history and ecology of an animal. For apex predators that can impact higher level ecosystem processes, such changes may have consequences for other species. Tiger sharks (Galeocerdo cuvier) are an apex predator in tropical seas, and, as adults, are highly migratory. However, little is known about ontogenetic changes in their body form, especially in relation to two aspects of shape that influence locomotion (caudal fin) and feeding (head shape). We captured digital images of the heads and caudal fins of live tiger sharks from Southern Florida and the Bahamas ranging in body size (hence age), and quantified shape of each using elliptical Fourier analysis. This revealed changes in the shape of the head and caudal fin of tiger sharks across ontogeny. Smaller juvenile tiger sharks show an asymmetrical tail with the dorsal (upper) lobe being substantially larger than the ventral (lower) lobe, and transition to more symmetrical tail in larger adults, although the upper lobe remains relatively larger in adults. The heads of juvenile tiger sharks are more conical, which transition to relatively broader heads over ontogeny. We interpret these changes as a result of two ecological transitions. First, adult tiger sharks can undertake extensive migrations and a more symmetrical tail could be more efficient for swimming longer distances, although we did not test this possibility. Second, adult tiger sharks expand their diet to consume larger and more diverse prey with age (turtles, mammals, and elasmobranchs), which requires substantially greater bite area and force to process. In contrast, juvenile tiger sharks consume smaller prey, such as fishes, crustaceans, and invertebrates. Our data reveal significant morphological shifts in an apex predator, which could have effects for other species that tiger sharks consume and interact with. © 2016 Wiley Periodicals, Inc.

Anatomic Optical Coherence Tomography of Upper Airways

NASA Astrophysics Data System (ADS)

Chin Loy, Anthony; Jing, Joseph; Zhang, Jun; Wang, Yong; Elghobashi, Said; Chen, Zhongping; Wong, Brian J. F.

The upper airway is a complex and intricate system responsible for respiration, phonation, and deglutition. Obstruction of the upper airways afflicts an estimated 12-18 million Americans. Pharyngeal size and shape are important factors in the pathogenesis of airway obstructions. In addition, nocturnal loss in pharyngeal muscular tone combined with high pharyngeal resistance can lead to collapse of the airway and periodic partial or complete upper airway obstruction. Anatomical optical coherence tomography (OCT) has the potential to provide high-speed three-dimensional tomographic images of the airway lumen without the use of ionizing radiation. In this chapter we describe the methods behind endoscopic OCT imaging and processing to generate full three dimensional anatomical models of the human airway which can be used in conjunction with numerical simulation methods to assess areas of airway obstruction. Combining this structural information with flow dynamic simulations, we can better estimate the site and causes of airway obstruction and better select and design surgery for patients with obstructive sleep apnea.

Preventive effects of conservative treatment with short-term teriparatide on the progression of vertebral body collapse after osteoporotic vertebral compression fracture.

PubMed

Park, J-H; Kang, K-C; Shin, D-E; Koh, Y-G; Son, J-S; Kim, B-H

2014-02-01

The progression of fractured vertebral collapse is not rare after a conservative treatment of vertebral compression fracture (VCF). Teriparatide has been shown to directly stimulate bone formation and improve bone density, but there is a lack of evidence regarding its use in fracture management. Conservative treatment with short-term teriparatide is effective for decreasing the progression of fractured vertebral body collapse. Few studies have reported on the prevention of collapsed vertebral body progression after osteoporotic VCF. Teriparatide rapidly enhances bone formation and increases bone strength. This study evaluated preventive effects of short-term teriparatide on the progression of vertebral body collapse after osteoporotic VCF. Radiographs of 68 women with single-level osteoporotic VCF at thoracolumbar junction (T11-L2) were reviewed. Among them, 32 patients were treated conservatively with teriparatide (minimum 3 months) (group I), and 36 were treated with antiresorptive (group II). We measured kyphosis and wedge angle of the fractured vertebral body, and ratios of anterior, middle, and posterior heights of the collapsed body to posterior height of a normal upper vertebra were determined. The degree of collapse progression was compared between two groups. The progression of fractured vertebral body collapse was shown in both groups, but the degree of progression was significantly lower in group I than in group II. At the last follow-up, mean increments of kyphosis and wedge angle were significantly lower in group I (4.0° ± 4.2° and 3.6° ± 3.6°) than in group II (6.8° ± 4.1° and 5.8° ± 3.5°) (p = 0.032 and p = 0.037). Decrement percentages of anterior and middle border height were significantly lower in group I (9.6 ± 10.3 and 7.4 ± 7.5 %) than in group II (18.1 ± 9.7 and 13.8 ± 12.2 %) (p = 0.001 and p = 0.025), but not in posterior height (p = 0.086). In female patients with single-level osteoporotic VCF at the thoracolumbar junction, short-term teriparatide treatment did not prevent but did decrease the progression of fractured vertebral body collapse.

Liquification and soft-sediment deformation in a limestone megabreccia: The Ayabacas giant collapse, Cretaceous, southern Peru

NASA Astrophysics Data System (ADS)

Callot, Pierre; Odonne, Francis; Sempere, Thierry

2008-12-01

In the back-arc basin of southern Peru, the bulk of the mid-Cretaceous carbonate platform collapsed near the Turonian-Coniacian boundary (~ 90-89 Ma), due to slope creation and resulting oversteepening. The resulting mass-wasting deposits, namely the Ayabacas Formation, consist of a megabreccia which is organised from NE to SW in relation with two major fault systems. Facies of sediment reworking (such as brecciation, liquification, sedimentary dykes and soft-sediment deformation) are described and four types of resedimentation facies are define. In the northeastern part of the study area, deposits mainly consist of a mixture of very heterometric clasts and blocks (millimetric to kilometric in size), mainly carbonate but also sandy-marly in nature, floating in sandy-marly matrix that exhibits features of liquification (sedimentary dykes and flows) and plastic deformation. Here, resedimentation facies are characterized by deformations and a brecciated facies at each observation scale (from aerial photographs to thin sections) and are therefore defined as fractal or multi-scale breccias. Some clasts and large amounts of the matrix were derived from the underlying clay-rich sandstones of the Murco Formation. These materials were prone to liquification and plastic deformation, allowing them to act as a sliding sole that facilitated the slides and the downslope movement of large limestone rafts. In the southwestern part of the study area, only limestone breccias are observed, in alternation with well-stratified levels. The sliding sole of plastically deformable siliciclastic sediments that previously acted as a lubricating layer was not present here, as materials were more deeply buried. Variations in the degree of sediment lithification from northeast to southwest are inferred to have existed before the collapse and also within the sedimentary succession in the northeastern part. In particular, limestones were well-cemented at the base of the carbonate succession and formed a cap that prevented water to escape from the underlying siliciclastic materials. Such a succession allowed the formation of limestone clasts and of a slide sole constituted by water-saturated siliciclastic materials. In the southern part of the study area, the slide surface was located within the Murco Formation in the upper part of the collapse and just above the Murco Formation downslope. The collapse was frontally confined as it was blocked downslope by a topographic high that folded the whole limestone succession. In the northern part of the study area, the slide surface was also within the Murco Formation in the upper part, but occurs within the limestone succession downslope, due to higher subsidence that buried the sediments more deeply. The compressional structures affecting the limestone succession in the south are not observed there, suggesting that the toe of the collapse was not blocked here.

Levator Glandulae Thyroideae, a Fibromusculoglandular Band with Absence of Pyramidal Lobe and Its Innervation: A Case Report

PubMed Central

Chaudhary, Priti; Singh, Zora; Khullar, Meenakshi; Arora, Kamal

2013-01-01

Amongst the endocrine glands, thyroid gland is well known for its developmental anomalies, which range from common to rare ones. The presence of levator glandulae thyroideae and its anatomical variations gain importance in the pathologies which are related to thyroid gland and their treatment modalities. Levator glandulae thyroideae is a fibromuscular band. If it is present, it is usually seen on the left side, to connect the pyramidal lobe of thyroid gland and the hyoid bone. But levator glandulae thyroideae which stretches from isthmus to the body of hyoid bone is rare and only very few cases have been reported in the medical literature. During a routine dissection of the thyroid gland in a 55 years old male cadaver, a Levator Glandulae Thyroideae (which was fibromusculoglandular in nature) was seen, with the absence of pyramidal lobe on the left side. It directly came from upper border of isthmus and went upto hyoid bone. It also had innervation from branches of external laryngeal nerve. This was also associated with absence of superior thyroid artery on the same side. The knowledge on various developmental anomalies of the gland and variations in neurovascular relations will help the surgeons in plan thyroid surgeries in a better and safe way. PMID:23998080

Three-dimensional geophysical mapping of shallow water saturated altered rocks at Mount Baker, Washington: Implications for slope stability

NASA Astrophysics Data System (ADS)

Finn, Carol A.; Deszcz-Pan, Maryla; Ball, Jessica L.; Bloss, Benjamin J.; Minsley, Burke J.

2018-05-01

Water-saturated hydrothermal alteration reduces the strength of volcanic edifices, increasing the potential for catastrophic sector collapses that can lead to far traveled and destructive debris flows. Intense hydrothermal alteration significantly lowers the resistivity and magnetization of volcanic rock and therefore hydrothermally altered rocks can be identified with helicopter electromagnetic and magnetic measurements. Geophysical models constrained by rock properties and geologic mapping show that intensely altered rock is restricted to two small (500 m diameter), >150 m thick regions around Sherman Crater and Dorr Fumarole Field at Mount Baker, Washington. This distribution of alteration contrasts with much thicker and widespread alteration encompassing the summits of Mounts Adams and Rainier prior to the 5600 year old Osceola collapse, which is most likely due to extreme erosion and the limited duration of summit magmatism at Mount Baker. In addition, the models suggest that the upper 300 m of rock contains water which could help to lubricate potential debris flows. Slope stability modeling incorporating the geophysically modeled distribution of alteration and water indicates that the most likely and largest ( 0.1 km3) collapses are from the east side of Sherman Crater. Alteration at Dorr Fumarole Field raises the collapse hazard there, but not significantly because of its lower slope angles. Geochemistry and analogs from other volcanoes suggest a model for the edifice hydrothermal system.

Endoscopy of the upper respiratory tract during treadmill exercise: a clinical study of 100 horses.

PubMed

Kannegieter, N J; Dore, M L

1995-03-01

Endoscopy of the upper respiratory tract was performed in 100 horses during high speed treadmill exercise. Reasons for endoscopy were a history of an abnormal noise during exercise in 75 horses, poor performance in 17 horses and to evaluate the results of upper respiratory tract surgery in 8 horses. Of the 75 horses with a history of an abnormal noise during exercise the cause was determined in 67 (89%). Endoscopic abnormalities were detected at rest in 40 of these 75 horses (53%). In these 40 horses, a similar diagnosis as to the cause of the abnormal noise was made at rest and during exercise on the treadmill in 19 cases, while in the remaining 21 the endoscopic findings during exercise varied from that seen at rest. This included 3 horses in which a diagnosis was made at rest but no abnormalities were detected during exercise. Some of the findings during treadmill endoscopy included laryngeal dysfunction, grades 3, 4 and 5 (22 cases), dorsal displacement of the soft palate (20), epiglottic entrapment (8), epiglottic flutter (4), aryepiglottic fold flutter (4), pharyngeal collapse (3), arytenoiditis (3), vocal cord flutter (3), false nostril noise (2), pharyngeal lymphoid hyperplasia (2), soft palate haemorrhage (1) and positional arytenoid collapse (1). More than one abnormality was observed during exercise in 7 horses. A complete and correct diagnosis based on the resting endoscopy findings alone was made in 19 (25%) of these 75 cases. In the 17 horses examined because of poor performance, no abnormalities were detected during treadmill endoscopy that were not evident at rest.(ABSTRACT TRUNCATED AT 250 WORDS)

Cortical Drive to Breathe during Wakefulness in Patients with Obstructive Sleep Apnea Syndrome.

PubMed

Launois, Claire; Attali, Valérie; Georges, Marjolaine; Raux, Mathieu; Morawiec, Elise; Rivals, Isabelle; Arnulf, Isabelle; Similowski, Thomas

2015-11-01

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity. The objective of this study was to test whether awake OSAS patients would exhibit a similar cortical activity. Descriptive physiology study. Sleep laboratory in a large university affiliated tertiary hospital. 26 patients with moderate OSAS according to polysomnography (5 < apnea-hypopnea index [AHI] ≤ 30, n = 14) or severe OSAS (AHI > 30, n = 12); 13 non-OSAS patients for comparison. None. Respiratory time-locked electroencephalographic segments ensemble averaged and analyzed for slow premotor potentials preceding inspiration ("pre-inspiratory potentials" [PIPs]). PIPs were present in 1/13 controls and 11/26 patients (P = 0.0336; 4/14 "moderate" and 7/12 "severe" patients). Awake OSAS patients therefore exhibit respiratory-related cortical activity during quiet breathing significantly more frequently than non-OSAS individuals. The corresponding PIPs resemble those observed during prepared voluntary inspirations and in response to experimental inspiratory loads in normal subjects, which involve a cortical network comprising the supplementary motor area. A respiratory-related cortical activity could contribute to the increased neural drive to upper airway and to inspiratory muscles that has previously been described in obstructive sleep apnea, and could therefore contribute to the arousal-dependent compensation of upper airway abnormalities. Whether or not such cortical compensatory mechanisms have cognitive consequences remains to be determined. © 2015 Associated Professional Sleep Societies, LLC.

A 61-year-old man with cough and white sputum

PubMed Central

Yao, Yanwen; Yin, Jie; Xiao, Xinwu; Lv, Tangfeng; Sun, Wenkui

2015-01-01

A 61-year-old man with cough and white sputum had an abnormal pulmonary mass in the left lower lobe in the computed tomography (CT) imaging. According to the lung cancer multidisciplinary team (MDT) discussion, the patient took the left lower lobe resection and lymphadenectomy and finally diagnosed as left lung adenocarcinoma with TNM stage IIIA (pT3N2M0). After four cycles of postoperative chemotherapy with pemetrexed and nedaplatin and 10-month release, a solitary pulmonary nodule (SPN) appeared in the middle lobe of right lung in CT scanning. The patient took a second operation “the right middle lobe resection” and was diagnosed as left lung adenocarcinoma at TNM stage IV (pT3N2M1a, two lungs) with neither EGFR mutation nor ALK-EML4 fusion gene. After operation, the patient took another four cycles of postoperative chemotherapy with Docetaxel and Nedaplatin. During the follow-up, another PET/CT scanning reported that several enlarged mediastinal lymph nodes, a SPN in left upper lobe and lesion in cerebellum and the brain metastasis was also proved in MRI. The patient was now diagnosed as left lung adenocarcinoma at TNM stage IV (pT3N2M1b, brain). In the third-line therapy, the patient took the stereotactic radiotherapy for metastatic mediastinal lymph nodes and took erlotinib once a day after the radiotherapy. However, the number of small lesions on lungs was increased and the brain metastasis was enlarged. The stereotactic radiotherapy for the single brain metastasis and single agent chemotherapy of abraxane were taken. The whole body examination suggested that there was progression-free after two cycles of chemo. The patient is now took five cycles of single agent chemotherapy of abraxane. The latest whole body examination showed disease was stable with no new lesions and metastasis, performance status (PS) score is 0 and the overall survival (OS) time is 34 months. PMID:25806349

BSRs Elevated by Fluid Upwelling on the Upper Amazon Fan : Bottom-up Controls on Gas Hydrate Stability

NASA Astrophysics Data System (ADS)

Praeg, D.; Silva, C. G.; dos Reis, A. T.; Ketzer, J. M.; Unnithan, V.; Perovano Da Silva, R. J.; Cruz, A. M.; Gorini, C.

2017-12-01

The stability of natural gas hydrate accumulations on continental margins has mainly been considered in terms of changes in seawater pressures and temperatures driven from above by climate. We present evidence from the Amazon deep-sea fan for stability zone changes driven from below by fluid upwelling. A grid of 2D and 3D multichannel seismic data show the upper Amazon fan in water depths of 1200-2000 m to contain a discontinuous bottom-simulating seismic reflection (BSR) that forms `patches' 10-50 km wide and up to 140 km long, over a total area of at least 5000 km2. The elongate BSR patches coincide with anticlinal thrust-folds that record on-going gravitational collapse of the fan above décollements at depths of up to 10 km. The BSR lies within 100-300 m of seafloor, in places rising beneath features that seafloor imagery show to be pockmarks and mud volcanoes, some venting gas to the water column. The BSR patches are up to 500 m shallower than predicted for methane hydrate based on geothermal gradients as low as 17˚C/km measured within the upper fan, and inversion of the BSR to obtain temperatures at the phase boundary indicates gradients 2-5 times background levels. We interpret the strongly elevated BSR patches to record upwelling of warm gas-rich fluids through thrust-fault zones 101 km wide. We infer this process to favour gas hydrate occurrences that are concentrated in proportion to flux and locally pierced by vents, and that will be sensitive to temporal variations in the upward flux of heat and gas. Thus episodes of increased flux, e.g. during thrusting, could dissociate gas hydrates to trigger slope failures and/or enhanced gas venting to the ocean. Structurally-driven fluid flow episodes could account for evidence of recurrent large-scale failures from the compressive belt on the upper fan during its Neogene collapse, and provide a long-term alternative to sea level triggering. The proposed mechanism of upward flux links the distribution and stability of gas hydrate occurrences (and gas vents) to the internal dynamics of deep-sea depocentres, in all water depths that structural pathways for fluid migration may form. Gravitational collapse is increasingly recognized to affect passive continental margins, and our findings challenge global models of hydrate inventory over time based solely on in situ methanogenesis.

Obstructive sleep apnea.

PubMed

White, David P; Younes, Magdy K

2012-10-01

Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of the pharyngeal airway during sleep. Control of pharyngeal patency is a complex process relating primarily to basic anatomy and the activity of many pharyngeal dilator muscles. The control of these muscles is regulated by a number of processes including respiratory drive, negative pressure reflexes, and state (sleep) effects. In general, patients with OSA have an anatomically small airway the patency of which is maintained during wakefulness by reflex-driven augmented dilator muscle activation. At sleep onset, muscle activity falls, thereby compromising the upper airway. However, recent data suggest that the mechanism of OSA differs substantially among patients, with variable contributions from several physiologic characteristics including, among others: level of upper airway dilator muscle activation required to open the airway, increase in chemical drive required to recruit the pharyngeal muscles, chemical control loop gain, and arousal threshold. Thus, the cause of sleep apnea likely varies substantially between patients. Other physiologic mechanisms likely contributing to OSA pathogenesis include falling lung volume during sleep, shifts in blood volume from peripheral tissues to the neck, and airway edema. Apnea severity may progress over time, likely due to weight gain, muscle/nerve injury, aging effects on airway anatomy/collapsibility, and changes in ventilatory control stability. © 2012 American Physiological Society

Long-term survival in bronchogenic carcinoma with a solitary metastasis.

PubMed

Shachor, J; Luria, H; Cordova, M; Bernheim, J; Griffel, B; Bruderman, I

1986-03-01

Partial resection of a huge anaplastic large cell carcinoma of the upper lobe of the right lung was performed in a 47-year-old patient in order to relieve symptoms of pulmonary hypertrophic osteoarthropathy. Several months later a solitary metastasis was noted in the muscles of the right forearm. The metastasis was resected and the forearm irradiated. The patient was further treated with injections of autologous tumour cell vaccine and BCG. Today, 7 years later, the patient is alive, without any signs of neoplastic disease.

Anesthetic challenges of a patient with the communicating bulla coming for nonthoracic surgery.

PubMed

Theodare, Bernice; Nissy, Vinolia Victory; Sahajanandan, Raj; Mariappan, Ramamani

2018-01-01

Management of a patient with a giant bulla coming for a nonthoracic surgery is rare, and its anesthetic management is very challenging. It is imperative to isolate only the subsegmental bronchus, in which the bulla communicates to avoid respiratory morbidities such as pneumothorax, emphysema or atelectasis of the surrounding lung parenchyma, and postoperative respiratory failure. Herewith, we want to report the anesthetic challenges of a patient with giant bulla communicating into one of the subsegmental right upper lobe bronchus for splenectomy.

Invasive pulmonary aspergillosis in an immunocompetent patient with severe dengue fever

PubMed Central

Nasa, Prashant; Yadav, Rohit; Nagrani, S.K.; Raina, Sanjay; Gupta, Ankur; Jain, Shakti

2014-01-01

We report a case of a 65-year-old female diagnosed with sever dengue fever. She started showing recovery from dengue fever with medical management. On day 6 of admission, she had leukocytosis, altered mental sensorium, and hemoptysis. Chest tomography showed air space consolidation with multiple nodules in the left upper and middle lobe sputum and bronchoalveolar lavage cultures were positive for Aspergillus flavus. The patient showed improvement with voriconazole and therapy was continued for 6 weeks. PMID:24914263

Invasive pulmonary aspergillosis in an immunocompetent patient with severe dengue fever.

PubMed

Nasa, Prashant; Yadav, Rohit; Nagrani, S K; Raina, Sanjay; Gupta, Ankur; Jain, Shakti

2014-05-01

We report a case of a 65-year-old female diagnosed with sever dengue fever. She started showing recovery from dengue fever with medical management. On day 6 of admission, she had leukocytosis, altered mental sensorium, and hemoptysis. Chest tomography showed air space consolidation with multiple nodules in the left upper and middle lobe sputum and bronchoalveolar lavage cultures were positive for Aspergillus flavus. The patient showed improvement with voriconazole and therapy was continued for 6 weeks.

Rothia mucilaginosa pneumonia in an immunocompetent patient.

PubMed

Baeza Martínez, Carlos; Zamora Molina, Lucia; García Sevila, Raquel; Gil Carbonell, Joan; Ramos Rincon, José Manuel; Martín Serrano, Concepción

2014-11-01

Rothia mucilaginosa is a gram-postive coccus that occurs as part of the normal flora of the oropharynx and upper respiratory tract. Lower respiratory tract infections caused by this organism are rare and usually occur in immunocompromised patients. This is the case of an immunocompetent 47-year-old woman with right upper lobe pneumonia in which R.mucilaginosa was isolated in sputum and bronchial aspirate. Infections caused by this agent in the last four years in our hospital were reviewed. The most common predisposing factor was COPD with bronchiectasis. R.mucilaginosa was identified as the causative agent for pneumonia in only two cases, of which one was our case and the other was a patient with lung cancer. Copyright © 2013 SEPAR. Published by Elsevier Espana. All rights reserved.

Adult obstructive sleep apnoea.

PubMed

Jordan, Amy S; McSharry, David G; Malhotra, Atul

2014-02-22

Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway collapse during sleep, leading to oxygen desaturation and disrupted sleep. Features include snoring, witnessed apnoeas, and sleepiness. Pathogenesis varies; predisposing factors include small upper airway lumen, unstable respiratory control, low arousal threshold, small lung volume, and dysfunctional upper airway dilator muscles. Risk factors include obesity, male sex, age, menopause, fluid retention, adenotonsillar hypertrophy, and smoking. Obstructive sleep apnoea causes sleepiness, road traffic accidents, and probably systemic hypertension. It has also been linked to myocardial infarction, congestive heart failure, stroke, and diabetes mellitus though not definitively. Continuous positive airway pressure is the treatment of choice, with adherence of 60-70%. Bi-level positive airway pressure or adaptive servo-ventilation can be used for patients who are intolerant to continuous positive airway pressure. Other treatments include dental devices, surgery, and weight loss. Copyright © 2014 Elsevier Ltd. All rights reserved.

Postoperative respiratory muscle dysfunction: pathophysiology and preventive strategies.

PubMed

Sasaki, Nobuo; Meyer, Matthew J; Eikermann, Matthias

2013-04-01

Postoperative pulmonary complications are responsible for significant increases in hospital cost as well as patient morbidity and mortality; respiratory muscle dysfunction represents a contributing factor. Upper airway dilator muscles functionally resist the upper airway collapsing forces created by the respiratory pump muscles. Standard perioperative medications (anesthetics, sedatives, opioids, and neuromuscular blocking agents), interventions (patient positioning, mechanical ventilation, and surgical trauma), and diseases (lung hyperinflation, obesity, and obstructive sleep apnea) have differential effects on the respiratory muscle subgroups. These effects on the upper airway dilators and respiratory pump muscles impair their coordination and function and can result in respiratory failure. Perioperative management strategies can help decrease the incidence of postoperative respiratory muscle dysfunction. Such strategies include minimally invasive procedures rather than open surgery, early and optimal mobilizing of respiratory muscles while on mechanical ventilation, judicious use of respiratory depressant anesthetics and neuromuscular blocking agents, and noninvasive ventilation when possible.

Rare cause of upper gastrointestinal bleeding owing to hepatic cancer invasion: a case report.

PubMed

Wu, Wei-Ding; Wu, Jia; Yang, Hong-Guo; Chen, Yuan; Zhang, Cheng-Wu; Zhao, Da-Jian; Hu, Zhi-Ming

2014-09-21

Upper gastrointestinal bleeding refers to bleeding that arises from the gastrointestinal tract proximal to the ligament of Treitz. The primary reason for gastrointestinal bleeding associated with hepatocellular carcinoma is rupture of a varicose vein owing to pericardial hypotension. We report a rare case of gastrointestinal bleeding with hepatocellular carcinoma in a patient who presented with recurrent gastrointestinal bleeding. The initial diagnosis was gastric cancer with metastasis to the multiple lymph nodes of the lesser curvature. The patient underwent exploratory laparotomy, which identified two lesions in the gastric wall. Total gastrectomy and hepatic local excision was then performed. Pathological results indicated that the hepatocellular carcinoma had invaded the stomach directly, which was confirmed immunohistochemically. The patient is alive with a disease-free survival of 1 year since the surgery. Hepatocellular carcinoma with gastric invasion should be considered as a rare cause of upper gastrointestinal bleeding in hepatocellular carcinoma patients, especially with lesions located in the left lateral hepatic lobe. Surgery is the best solution.

The mass media and disasters

USGS Publications Warehouse

Rogers, E. M.

1990-01-01

Past investigations by myself and others on the role of the mass media in disasters indicate that news people typically find themselves in situations of uncertainty, ambiguity, and conflicting information; the communication and transportation services that these people use in covering a story become inoperative. However, the media are expected to make sense of the disaster situation almost immediately. the difficulties of doing so were reflected by the ABC Goodyear Blimp footage of the collapsed Nimitz Freeway in Oakland, California, broadcast nationally on the evening of October 17, 1989. The televised picture showed the disastrous results of the Loma Prieta earthquake, but for an hour or more the announcer could not correctly identify what was being shown. He did not seem to realize that the upper deck of the freeway had collapsed on the lower deck, crushing vechiles and people. 

Thermodynamic models for bounding pressurant mass requirements of cryogenic tanks

NASA Technical Reports Server (NTRS)

Vandresar, Neil T.; Haberbusch, Mark S.

1994-01-01

Thermodynamic models have been formulated to predict lower and upper bounds for the mass of pressurant gas required to pressurize a cryogenic tank and then expel liquid from the tank. Limiting conditions are based on either thermal equilibrium or zero energy exchange between the pressurant gas and initial tank contents. The models are independent of gravity level and allow specification of autogenous or non-condensible pressurants. Partial liquid fill levels may be specified for initial and final conditions. Model predictions are shown to successfully bound results from limited normal-gravity tests with condensable and non-condensable pressurant gases. Representative maximum collapse factor maps are presented for liquid hydrogen to show the effects of initial and final fill level on the range of pressurant gas requirements. Maximum collapse factors occur for partial expulsions with large final liquid fill fractions.

Constraints on high-energy neutrino emission from SN 2008D

NASA Astrophysics Data System (ADS)

IceCube Collaboration; Abbasi, R.; Abdou, Y.; Abu-Zayyad, T.; Adams, J.; Aguilar, J. A.; Ahlers, M.; Andeen, K.; Auffenberg, J.; Bai, X.; Baker, M.; Barwick, S. W.; Bay, R.; Bazo Alba, J. L.; Beattie, K.; Beatty, J. J.; Bechet, S.; Becker, J. K.; Becker, K.-H.; Benabderrahmane, M. L.; Ben Zvi, S.; Berdermann, J.; Berghaus, P.; Berley, D.; Bernardini, E.; Bertrand, D.; Besson, D. Z.; Bissok, M.; Blaufuss, E.; Blumenthal, J.; Boersma, D. J.; Bohm, C.; Bose, D.; Böser, S.; Botner, O.; Braun, J.; Buitink, S.; Carson, M.; Chirkin, D.; Christy, B.; Clem, J.; Clevermann, F.; Cohen, S.; Colnard, C.; Cowen, D. F.; D'Agostino, M. V.; Danninger, M.; Davis, J. C.; De Clercq, C.; Demirörs, L.; Depaepe, O.; Descamps, F.; Desiati, P.; de Vries-Uiterweerd, G.; DeYoung, T.; Díaz-Vélez, J. C.; Dierckxsens, M.; Dreyer, J.; Dumm, J. P.; Duvoort, M. R.; Ehrlich, R.; Eisch, J.; Ellsworth, R. W.; Engdegård, O.; Euler, S.; Evenson, P. A.; Fadiran, O.; Fazely, A. R.; Fedynitch, A.; Feusels, T.; Filimonov, K.; Finley, C.; Foerster, M. M.; Fox, B. D.; Franckowiak, A.; Franke, R.; Gaisser, T. K.; Gallagher, J.; Geisler, M.; Gerhardt, L.; Gladstone, L.; Glüsenkamp, T.; Goldschmidt, A.; Goodman, J. A.; Grant, D.; Griesel, T.; Gro, A.; Grullon, S.; Gurtner, M.; Ha, C.; Hallgren, A.; Halzen, F.; Han, K.; Hanson, K.; Helbing, K.; Herquet, P.; Hickford, S.; Hill, G. C.; Hoffman, K. D.; Homeier, A.; Hoshina, K.; Hubert, D.; Huelsnitz, W.; Hül, J. P.; Hulth, P. O.; Hultqvist, K.; Hussain, S.; Ishihara, A.; Jacobsen, J.; Japaridze, G. S.; Johansson, H.; Joseph, J. M.; Kampert, K. H.; Kappes A.; Karg, T.; Karle, A.; Kelley, J. L.; Kemming, N.; Kenny, P.; Kiryluk, J.; Kislat, F.; Klein, S. R.; Köhne, J. H.; Kohnen, G.; Kolanoski, H.; Köpke, L.; Koskinen, D. J.; Kowalski, M.; Kowarik, T.; Krasberg, M.; Krings, T.; Kroll, G.; Kuehn, K.; Kuwabara, T.; Labare, M.; Lafebre, S.; Laihem, K.; Landsman, H.; Larson, M. J.; Lauer, R.; Lehmann, R.; Lünemann, J.; Madsen, J.; Majumdar, P.; Marotta, A.; Maruyama, R.; Mase, K.; Matis, H. S.; Matusik, M.; Meagher, K.; Merck, M.; Mészáros, P.; Meures, T.; Middell, E.; Milke, N.; Miller, J.; Montaruli, T.; Morse, R.; Movit, S. M.; Nahnhauer, R.; Nam, J. W.; Naumann, U.; Nießen, P.; Nygren, D. R.; Odrowski, S.; Olivas, A.; Olivo, M.; O'Murchadha, A.; Ono, M.; Panknin, S.; Paul, L.; Pérez de los Heros, C.; Petrovic, J.; Piegsa, A.; Pieloth, D.; Porrata, R.; Posselt, J.; Price, P. B.; Prikockis, M.; Przybylski, G. T.; Rawlins, K.; Redl, P.; Resconi, E.; Rhode, W.; Ribordy, M.; Rizzo, A.; Rodrigues, J. P.; Roth, P.; Rothmaier, F.; Rott, C.; Ruhe, T.; Rutledge, D.; Ruzybayev, B.; Ryckbosch, D.; Sander, H.-G.; Santander, M.; Sarkar, S.; Schatto, K.; Schlenstedt, S.; Schmidt, T.; Schukraft, A.; Schultes, A.; Schulz, O.; Schunck, M.; Seckel, D.; Semburg, B.; Seo, S. H.; Sestayo, Y.; Seunarine, S.; Silvestri, A.; Singh, K.; Slipak, A.; Spiczak, G. M.; Spiering, C.; Stamatikos, M.; Stanev, T.; Stephens, G.; Stezelberger, T.; Stokstad, R. G.; Stoyanov, S.; Strahler, E. A.; Straszheim, T.; Sullivan, G. W.; Swillens, Q.; Taavola, H.; Taboada, I.; Tamburro, A.; Tarasova, O.; Tepe, A.; Ter-Antonyan, S.; Tilav, S.; Toale, P. A.; Toscano, S.; Tosi, D.; Turčan, D.; van Eijndhoven, N.; Vandenbroucke, J.; Van Overloop, A.; van Santen, J.; Voge, M.; Voigt, B.; Walck, C.; Waldenmaier, T.; Wallraff, M.; Walter, M.; Weaver, Ch.; Wendt, C.; Westerhoff, S.; Whitehorn, N.; Wiebe, K.; Wiebusch, C. H.; Wikström, G.; Williams, D. R.; Wischnewski, R.; Wissing, H.; Wolf, M.; Woschnagg, K.; Xu, C.; Xu, X. W.; Yodh, G.; Yoshida, S.; Zarzhitsky, P.

2011-03-01

SN 2008D, a core collapse supernova at a distance of 27 Mpc, was serendipitously discovered by the Swift satellite through an associated X-ray flash. Core collapse supernovae have been observed in association with long gamma-ray bursts and X-ray flashes and a physical connection is widely assumed. This connection could imply that some core collapse supernovae possess mildly relativistic jets in which high-energy neutrinos are produced through proton-proton collisions. The predicted neutrino spectra would be detectable by Cherenkov neutrino detectors like IceCube. A search for a neutrino signal in temporal and spatial correlation with the observed X-ray flash of SN 2008D was conducted using data taken in 2007-2008 with 22 strings of the IceCube detector. Events were selected based on a boosted decision tree classifier trained with simulated signal and experimental background data. The classifier was optimized to the position and a "soft jet" neutrino spectrum assumed for SN 2008D. Using three search windows placed around the X-ray peak, emission time scales from 100-10 000 s were probed. No events passing the cuts were observed in agreement with the signal expectation of 0.13 events. Upper limits on the muon neutrino flux from core collapse supernovae were derived for different emission time scales and the principal model parameters were constrained. While no meaningful limits can be given in the case of an isotropic neutrino emission, the parameter space for a jetted emission can be constrained. Future analyses with the full 86 string IceCube detector could detect up to ~100 events for a core-collapse supernova at 10 Mpc according to the soft jet model.

A modified method using a two-port approach for accessing the hilar vasculature without transferring an endostapler from camera port to utility port during thoracoscopic right upper lobectomy.

PubMed

Jiao, W; Zhao, Y; Xuan, Y; Wang, M

2015-02-01

For thoracoscopic upper lobectomies, most cutting endostaplers must be inserted through the camera port when using a two-port approach. Access to the hilar vasculature through only the utility port remains a challenge. In this study, we describe a procedure to access the hilar vasculature without transferring the endostapler site during a thoracoscopic right upper lobectomy. A 2.5-cm utility anterior incision was made in the fourth intercostal space. The posterior mediastinal visceral pleura were dissected to expose the posterior portion of the right upper bronchus and the anterior trunk of the right pulmonary artery. The pleura over the right hilar vasculature were then peeled with an electrocoagulation hook. The anterior trunk of the right pulmonary artery was then transected with a cutting endostapler through the utility port firstly. This crucial maneuver allowed the endostapler access to the right upper lobe pulmonary vein. The hilar structures were then easily handled in turn. This novel technique was performed successfully in 32 patients, with no perioperative deaths. The average operation time was 120.6 min (range 75-180 min). This novel technique permits effective control of the hilar vessels through the utility port, enabling simple, safe, quick and effective resection.

Radiation patterns of interfacial dipole antennas

NASA Technical Reports Server (NTRS)

Engheta, N.; Papas, C. H.; Elachi, C.

1982-01-01

The radiation pattern of an infinitesimal electric dipole is calculated for the case where the dipole is vertically located on the plane interface of two dielectric half spaces and for the case where the dipole is lying horizontally along the interface. For the vertical case, it is found that the radiation pattern has nulls at the interface and along the dipole axis. For the horizontal case, it is found that the pattern has a null at the interface; that the pattern in the upper half space, whose index of refraction is taken to be less than that of the lower half space, has a single lobe whose maximum is normal to the interface; and that in the lower half space, in the plane normal to the interface and containing the dipole, the pattern has three lobes, whereas in the plane normal to the interface and normally bisecting the dipole, the pattern has two maxima located symmetrically about a minimum. Interpretation of these results in terms of the Cerenkov effect is given.

Cystic echinococcosis: a disease mimicking cancer in a non-endemic country report of two cases.

PubMed

Comrnejo-Juárez, P; Espinosa-Altamirano, A; Ibarra-del-Río, M; Pacheco-Bravo, I; Volkow-Fernández, P

2013-03-01

Echinococcosis is a parasitic disease that involves dogs as definitive host and sheep as intermediate host. Humans become infected incidentally through fecal-oral contact, particularly in the course of playful and close contact with an infected dog. Mexico is considered a region that is virtually free of cystic echinoccocosis. This manuscript describes two cases that were referred to a tertiary-care oncology hospital with a diagnosis of cancer. In one case, the presumptive diagnosis was liver cancer because abdominal ultrasonography revealed a low-density mass in the right hepatic lobe. Drainage was performed and cytologic examination of the fluid showed multiple Echinococcus cyst as well as prostoscolex. The case was resolved with percutaneous drainage and administration of albendazole for two months. In the second case, the patient was referred with a diagnosis of disseminated cervical cancer A cyst was identified in the upper right lung lobe; a diagnostic puncture was performed showing an Echinococcus cyst. This resolved solely with two months of albendazole administration.

[Lung abscess which needed to be distinguished from lung cancer; report of a case].

PubMed

Kamiya, Kazunori; Yoshizu, Akira; Misumi, Yuki; Hida, Naoya; Okamoto, Hiroaki; Yoshida, Sachiko

2011-12-01

Differential diagnosis of lung abscess from lung cancer is sometimes difficult. In February 2009, a 57-year-old man consulted our hospital complaining of bloody sputum. Chest computed tomography (CT) demonstrated a 2.5 cm nodule with pleural indentation, spicula and vascular involvement in the right S(3). Bronchofiberscope could not establish a definitive diagnosis. Blood test showed no abnormality. Three months later, progression of the nodule to the adjacent middle lobe was demonstrated by follow-up CT, and F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) showed isotope accumulation in the nodule and hilar lymph node. A diagnosis of lung cancer was suspected and surgery was performed. The diagnosis of possible lung cancer was made by needle biopsy, and the patient underwent right upper lobectomy and partial resection of middle lobe with standard nodal dissection. The final pathological diagnosis was lung abscess. Lung abscess must be kept in mind as a possible differential diagnosis when abnormal shadow suspected of lung cancer is observed.

Albumin and magnetic resonance imaging-liver volume to identify hepatitis B-related cirrhosis and esophageal varices

PubMed Central

Li, Hang; Chen, Tian-Wu; Li, Zhen-Lin; Zhang, Xiao-Ming; Li, Cheng-Jun; Chen, Xiao-Li; Chen, Guang-Wen; Hu, Jia-Ni; Ye, Yong-Quan

2015-01-01

AIM: To investigate whether liver lobe volume and albumin (ALB) could predict the presence and severity of liver cirrhosis, and esophageal varices. METHODS: Seventy-one cirrhotic patients with hepatitis B and 21 healthy individuals were enrolled in this study. All the participants underwent abdominal enhanced magnetic resonance imaging to measure each liver lobe volume, and biochemical workup for testing ALB and Child-Pugh class. All cirrhotic patients underwent upper gastrointestinal endoscopy to show the presence of cirrhotic esophageal varices. Right liver lobe volume (RV), left medial liver lobe volume (LMV), left lateral liver lobe volume (LLV), and caudate lobe volume (CV) were measured using enhanced magnetic resonance imaging. The ratios of RV to ALB (RV/ALB), LMV to ALB (LMV/ALB), LLV to ALB (LLV/ALB) and CV to ALB (CV/ALB) were calculated. Statistical analyses were performed to determine whether and how the combination of liver lobe volume measured using magnetic resonance imaging and albumin could predict the presence and severity of liver cirrhosis, and the presence of esophageal varices. RESULTS: RV, LMV, LLV and CV decreased (r = -0.51-0.373; all P < 0.05), while RV/ALB increased (r = 0.424; P < 0.05), with the progress of Child-Pugh class of liver cirrhosis. RV, LMV, CV, LLV/ALB and CV/ALB could identify presence of liver cirrhosis; LLV and LMV could distinguish Child-Pugh class A from B; RV, LMV, LLV, CV, RV/ALB and LLV/ALB could distinguish class A from C; RV and LLV/ALB could differentiate B from C; and RV, RV/ALB and CV/ALB could identify presence of esophageal varices (all P < 0.05). Among these parameters, CV/ALB could best identify the presence of liver cirrhosis, with an area under receiver operating characteristic curve (AUC) of 0.860, a sensitivity of 82.0% and a specificity of 83.0%. LLV could best distinguish class A from B, with an AUC of 0.761, a sensitivity of 74.4% and a specificity of 73.1%. RV could best distinguish class A from C, with an AUC of 0.900, a sensitivity of 90.3% and a specificity of 84.5%. LLV/ALB could best distinguish class B from C, with an AUC of 0.900, a sensitivity of 93.8% and a specificity of 81.5%. RV/ALB could best identify esophageal varices, with an AUC of 0.890, a sensitivity of 80.0% and a specificity of 83.5%. CONCLUSION: The combination of liver lobe volume and ALB has potential to identify presence and severity of cirrhosis, and presence of esophageal varices. PMID:25624735

Imaging Findings of Isolated Bronchial Anthracofibrosis: A Computed Tomography Analysis of Patients With Bronchoscopic and Histologic Confirmation.

PubMed

Kahkouee, Shahram; Pourghorban, Ramin; Bitarafan, Mahdi; Najafizadeh, Katayoun; Makki, Seyed Shahabeddin Mohammad

2015-07-01

To evaluate the chest computed tomography (CT) findings of patients with isolated bronchial anthracofibrosis confirmed by bronchoscopy and histopathology. Fifty-eight patients with isolated bronchial anthracofibrosis (29 females; mean age, 70 years) were enrolled in this study. The diagnosis of bronchial anthracofibrosis was made based on both bronchoscopy and pathology findings in all patients. The various chest CT images were retrospectively reviewed by two chest radiologists who reached decisions in consensus. Central peribronchial soft tissue thickening (n=37, 63.8%) causing bronchial narrowing (n=37, 63.8%) or obstruction (n=11, 19%) was identified as an important finding on imaging. Multiple bronchial stenoses with concurrent involvement of 2, 3, and 5 bronchi were seen in 12 (21%), 9 (15%), and 2 (3.4%) patients, respectively. Segmental atelectasis and lobar or multilobar collapse were detected. These findings mostly occurred in the right lung, predominantly in the right middle lobe. Mosaic attenuation patterns, scattered parenchymal nodules, nodular patterns, and calcified or non-calcified lymph nodes were also observed. On chest CT, isolated bronchial anthracofibrosis appeared as peribronchial soft tissue thickening, bronchial narrowing or obstruction, segmental atelectasis, and lobar or multilobar collapse. The findings were more common in the right side, with simultaneous involvement of multiple bronchi in some patients. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

Seismic responses and controlling factors of Miocene deepwater gravity-flow deposits in Block A, Lower Congo Basin

NASA Astrophysics Data System (ADS)

Wang, Linlin; Wang, Zhenqi; Yu, Shui; Ngia, Ngong Roger

2016-08-01

The Miocene deepwater gravity-flow sedimentary system in Block A of the southwestern part of the Lower Congo Basin was identified and interpreted using high-resolution 3-D seismic, drilling and logging data to reveal development characteristics and main controlling factors. Five types of deepwater gravity-flow sedimentary units have been identified in the Miocene section of Block A, including mass transport, deepwater channel, levee, abandoned channel and sedimentary lobe deposits. Each type of sedimentary unit has distinct external features, internal structures and lateral characteristics in seismic profiles. Mass transport deposits (MTDs) in particular correspond to chaotic low-amplitude reflections in contact with mutants on both sides. The cross section of deepwater channel deposits in the seismic profile is in U- or V-shape. The channel deposits change in ascending order from low-amplitude, poor-continuity, chaotic filling reflections at the bottom, to high-amplitude, moderate to poor continuity, chaotic or sub-parallel reflections in the middle section and to moderate-weak amplitude, good continuity, parallel or sub-parallel reflections in the upper section. The sedimentary lobes are laterally lobate, which corresponds to high-amplitude, good-continuity, moundy reflection signatures in the seismic profile. Due to sediment flux, faults, and inherited terrain, few mass transport deposits occur in the northeastern part of the study area. The front of MTDs is mainly composed of channel-levee complex deposits, while abandoned-channel and lobe-deposits are usually developed in high-curvature channel sections and the channel terminals, respectively. The distribution of deepwater channel, levee, abandoned channel and sedimentary lobe deposits is predominantly controlled by relative sea level fluctuations and to a lesser extent by tectonism and inherited terrain.

Marginal hepatectomy in the rat: from anatomy to surgery.

PubMed

Madrahimov, Nodir; Dirsch, Olaf; Broelsch, Christoph; Dahmen, Uta

2006-07-01

Based on the 3-dimensional visualization of vascular supply and drainage, a vessel-oriented resection technique was optimized. The new surgical technique was used to determine the maximal reduction in liver mass enabling a 50% 1-week survival rate. Determination of the minimal liver mass is necessary in clinical as well as in experimental liver surgery. In rats, survival seems to depend on the surgical technique applied. Extended hepatectomy with removal of 90% of the liver mass was long regarded as a lethal model. Introduction of a vessel-oriented approach enabled long-term survival in this model. The lobar and vascular anatomy of rat livers was visualized by plastination of the whole organ, respectively, by corrosion casts of the portal vein, hepatic artery and liver veins. The three-dimensional models were used to extract the underlying anatomic structure. In 90% partial hepatectomy, the liver parenchyma was clamped close to the base of the respective liver lobes (left lateral, median and right, liver lobe). Piercing sutures were placed through the liver parenchyma, so that the stem of portal vein and the accompanying hepatic artery but also the hepatic vein were included. A 1-week survival rate of 100% was achieved after 90% hepatectomy. Extending the procedure to 95% resection by additional removal of the upper caudate lobe led to a 1-week survival rate of 66%; 97% partial hepatectomy, accomplished by additional resection of the lower caudate lobe only leaving the paracaval parts of the liver behind, resulted in 100% lethality within 4 days. Using a anatomically based, vessel-oriented, parenchyma-preserving surgical technique in 95% liver resections led to long-term survival. This represents the maximal reduction of liver mass compatible with survival.

Visual cortex activation in kinesthetic guidance of reaching.

PubMed

Darling, W G; Seitz, R J; Peltier, S; Tellmann, L; Butler, A J

2007-06-01

The purpose of this research was to determine the cortical circuit involved in encoding and controlling kinesthetically guided reaching movements. We used (15)O-butanol positron emission tomography in ten blindfolded able-bodied volunteers in a factorial experiment in which arm (left/right) used to encode target location and to reach back to the remembered location and hemispace of target location (left/right side of midsagittal plane) varied systematically. During encoding of a target the experimenter guided the hand to touch the index fingertip to an external target and then returned the hand to the start location. After a short delay the subject voluntarily moved the same hand back to the remembered target location. SPM99 analysis of the PET data contrasting left versus right hand reaching showed increased (P < 0.05, corrected) neural activity in the sensorimotor cortex, premotor cortex and posterior parietal lobule (PPL) contralateral to the moving hand. Additional neural activation was observed in prefrontal cortex and visual association areas of occipital and parietal lobes contralateral and ipsilateral to the reaching hand. There was no statistically significant effect of target location in left versus right hemispace nor was there an interaction of hand and hemispace effects. Structural equation modeling showed that parietal lobe visual association areas contributed to kinesthetic processing by both hands but occipital lobe visual areas contributed only during dominant hand kinesthetic processing. This visual processing may also involve visualization of kinesthetically guided target location and use of the same network employed to guide reaches to visual targets when reaching to kinesthetic targets. The present work clearly demonstrates a network for kinesthetic processing that includes higher visual processing areas in the PPL for both upper limbs and processing in occipital lobe visual areas for the dominant limb.

The 15 September 1991 pyroclastic flows at Unzen Volcano (Japan): a flow model for associated ash-cloud surges

NASA Astrophysics Data System (ADS)

Fujii, Toshitsugu; Nakada, Setsuya

1999-04-01

Large-scale collapse of a dacite dome in the late afternoon of 15 September 1991 generated a series of pyroclastic-flow events at Unzen Volcano. Pyroclastic flows with a volume of 1×10 6 m 3 (as DRE) descended the northeastern slope of the volcano, changing their courses to the southeast due to topographic control. After they exited a narrow gorge, an ash-cloud surge rushed straight ahead, detaching the main body of the flow that turned and followed the topographic lows to the east. The surge swept the Kita-Kamikoba area, which had been devastated by the previous pyroclastic-flow events, and transported a car as far as 120 m. Following detachment, the surge lost its force after it moved several hundred meters, but maintained a high temperature. The deposits consist of a bottom layer of better-sorted ash (unit 1), a thick layer of block and ash (unit 2), and a thin top layer of fall-out ash (unit 3). Unit 2 overlies unit 1 with an erosional contact. The upper part of unit 2 grades into better-sorted ash. At distal block-and-ash flow deposits, the bottom part of unit 2 also consists of better-sorted ash, and the contact with the unit 1 deposits becomes ambiguous. Video footage of cascading pyroclastic flows during the 1991-1995 eruption, traveling over surfaces without any topographic barriers, revealed that lobes of ash cloud protruded intermittently from the moving head and sides, and that these lobes surged ahead on the ground surface. This fact, together with the inspection by helicopter shortly after the events, suggests that the protruded lobes consisted of better-sorted ash, and resulted in the deposits of unit 1. The highest ash-cloud plume at the Oshigadani valley exit, and the thickest deposition of fall-out ash over Kita-Kamikoba and Ohnokoba, indicate that abundant ash was also produced when the flow passed through a narrow gorge. In the model presented here, the ash clouds from the pyroclastic flows were composed of a basal turbulent current of high concentration (main body), an overriding and intermediate fluidization zone, and an overlying dilute cloud. Release of pressurized gas in lava block pores, due to collisions among blocks and the resulting upward current, caused a zone of fluidization just above the main body. The mixture of gas and ash sorted in the fluidization zone moved ahead and to the side of the main body as a gravitational current, where the ash was deposited as surge deposits. The main body, which had high internal friction and shear near its base, then overran the surge deposits, partially eroding them. When the upward current of gas (fluidization) waned, better-sorted ash suspended in the fluidization zone was deposited on block-and-ash deposits. In the distal places of block-and-ash deposits, unit 2 probably was deposited in non-turbulent fashion without any erosion of the underlying layer (unit 1).

Thoracic stomach-right main bronchus fistula treated with dual Y-shaped covered airway stents.

PubMed

Li, Z-M; Lu, H-B; Ren, K-W; Han, X-W; Wu, G; Jiao, D-C

2017-06-01

To determine the efficacy of dual Y-shaped covered airway stents to treat thoracic stomach-right main bronchus fistulae. Fifteen patients who developed thoracic stomach-right main bronchus fistula after oesophageal cancer resection and postoperative irradiation were retrospectively analysed. All fistulae were close to the right upper lobe bronchus. Two Y-shaped covered airway stents were designed for each patient. Under radiographic guidance, one stent was placed from the right main bronchus into the bifurcation of upper lobe and intermediate bronchus, the other was placed from the trachea into both main bronchi. All fistulae were closed immediately after stenting. All patients could eat a semi-solid diet. The symptom of coughing while lying down resolved in all patients, and no complications, such as airway bleeding or pneumothorax, occurred. The average survival time was 26.65 months (range 2-40 months, 11 patients were still alive at the study end). Two patients died of tumour recurrence. Another two patients died of pulmonary infections. In one of these patients, there was a long delay between symptom onset and stenting. In the other patient, a small rupture occurred in the silicone membrane covering the stent, which allowed the leakage of gastric contents into the lung. Dual Y-shaped covered airway stent placement is feasible and safe to treat thoracic stomach-right main bronchus fistulae. Improvements to the material covering the stents is required. Copyright © 2017. Published by Elsevier Ltd.

Improvement and Neuroplasticity after Combined Rehabilitation to Forced Grasping

PubMed Central

Ogata, Atsuko; Kawahira, Kazumi; Shimodozono, Megumi

2017-01-01

The grasp reflex is a distressing symptom but the need to treat or suppress it has rarely been discussed in the literature. We report the case of a 17-year-old man who had suffered cerebral infarction of the right putamen and temporal lobe 10 years previously. Forced grasping of the hemiparetic left upper limb was improved after a unique combined treatment. Botulinum toxin type A (BTX-A) was first injected into the left biceps, wrist flexor muscles, and finger flexor muscles. Forced grasping was reduced along with spasticity of the upper limb. In addition, repetitive facilitative exercise and object-related training were performed under low-amplitude continuous neuromuscular electrical stimulation. Since this 2-week treatment improved upper limb function, we compared brain activities, as measured by near-infrared spectroscopy during finger pinching, before and after the combined treatment. Brain activities in the ipsilesional sensorimotor cortex (SMC) and medial frontal cortex (MFC) during pinching under electrical stimulation after treatment were greater than those before. The results suggest that training under electrical stimulation after BTX-A treatment may modulate the activities of the ipsilesional SMC and MFC and lead to functional improvement of the affected upper limb with forced grasping. PMID:28265475

Neurophysiological substrates of stroke patients with motor imagery-based Brain-Computer Interface training.

PubMed

Li, Mingfen; Liu, Ye; Wu, Yi; Liu, Sirao; Jia, Jie; Zhang, Liqing

2014-06-01

We investigated the efficacy of motor imagery-based Brain Computer Interface (MI-based BCI) training for eight stroke patients with severe upper extremity paralysis using longitudinal clinical assessments. The results were compared with those of a control group (n = 7) that only received FES (Functional Electrical Stimulation) treatment besides conventional therapies. During rehabilitation training, changes in the motor function of the upper extremity and in the neurophysiologic electroencephalographic (EEG) were observed for two groups. After 8 weeks of training, a significant improvement in the motor function of the upper extremity for the BCI group was confirmed (p < 0.05 for ARAT), simultaneously with the activation of bilateral cerebral hemispheres. Additionally, event-related desynchronization (ERD) of the affected sensorimotor cortexes (SMCs) was significantly enhanced when compared to the pretraining course, which was only observed in the BCI group (p < 0.05). Furthermore, the activation of affected SMC and parietal lobe were determined to contribute to motor function recovery (p < 0.05). In brief, our findings demonstrate that MI-based BCI training can enhance the motor function of the upper extremity for stroke patients by inducing the optimal cerebral motor functional reorganization.

Cryptococcosis, silicosis, and tuberculous pseudotumor in the same pulmonary lobe*

PubMed Central

da Silva, Geruza Alves; Brandão, Daniel Ferracioli; Vianna, Elcio Oliveira; de Sá, João Batista Carlos; Baddini-Martinez, José

2013-01-01

Tuberculosis and cryptococcosis are infectious diseases that can result in the formation of single or multiple nodules in immunocompetent patients. Exposure to silica is known to raise the risk of infection with Mycobacterium tuberculosis. We report the case of an elderly man with no history of opportunistic infections and no clinical evidence of immunodeficiency but with a six-month history of dry cough and nocturnal wheezing. A chest X-ray revealed a mass measuring 5.0 × 3.5 cm in the right upper lobe. The diagnostic approach of the mass revealed tuberculosis. The histopathological analysis of the surrounding parenchyma reveled silicosis and cryptococcosis. Cryptococcosis was also found in masses identified in the mediastinal lymph nodes. The surgical approach was indicated because of the degree of pleuropulmonary involvement, the inconclusive results obtained with the invasive and noninvasive methods applied, and the possibility of malignancy. This case illustrates the difficulty inherent to the assessment of infectious or inflammatory pulmonary pseudotumors, the differential diagnosis of which occasionally requires a radical surgical approach. Despite the presence of respiratory symptoms for six months, the first chest X-ray was performed only at the end of that period. We discuss the possible pathogenic mechanisms that might have led to the combination of three types of granulomatous lesions in the same lobe, and we emphasize the need for greater awareness of atypical presentations of pulmonary tuberculosis. PMID:24310636

Tephra dispersal during the Campanian Ignimbrite (Italy) eruption: implications for ultra-distal ash transport during the large caldera-forming eruption

NASA Astrophysics Data System (ADS)

Smith, Victoria C.; Isaia, Roberto; Engwell, Sam L.; Albert, Paul. G.

2016-06-01

The Campanian Ignimbrite eruption dispersed ash over much of the central eastern Mediterranean Sea and eastern Europe. The eruption started with a Plinian phase that was followed by a series of pyroclastic density currents (PDCs) associated with the collapse of the Plinian column and the caldera. The glass compositions of the deposits span a wide geochemical range, but the Plinian fallout and PDCs associated with column collapse, the Lower Pumice Flow, only erupted the most evolved compositions. The later PDCs, the Breccia Museo and Upper Pumice Flow, erupted during and after caldera collapse, tap a less evolved component, and intermediate compositions that represent mixing between the end-members. The range of glass compositions in the Campanian Ignimbrite deposits from sites across the central and eastern Mediterranean Sea allow us to trace the dispersal of the different phases of this caldera-forming eruption. We map the fallout from the Plinian column and the plumes of fine material associated with the PDCs (co-PDCs) across the entire dispersal area. This cannot be done using the usual grain-size methods as deposits in these distal regions do not retain characteristics that allow attribution to either the Plinian or co-PDC phases. The glass compositions of the tephra at ultra-distal sites (>1500 km from the vent) match those of the uppermost PDC units, suggesting that most of the ultra-distal dispersal was associated with the late co-PDC plume that was generated during caldera collapse.

Experimental and numerical study of the effects of a wall on the coalescence and collapse of bubble pairs

NASA Astrophysics Data System (ADS)

Han, Rui; Zhang, A.-Man; Li, Shuai; Zong, Zhi

2018-04-01

Two-bubble interaction is the most fundamental problem in multi-bubbles dynamics, which is crucial in many practical applications involving air-gun arrays and underwater explosions. In this paper, we experimentally and numerically investigate coalescence, collapse, and rebound of non-buoyant bubble pairs below a rigid wall. Two oscillating vapor bubbles with similar size are generated simultaneously near a rigid wall in axisymmetric configuration using the underwater electric discharge method, and the physical process is captured by a high-speed camera. Numerical simulations are conducted based on potential flow theory coupled with the boundary integral method. Our numerical results show excellent agreement with the experimental data until the splashing of the jet impact sets in. With different ranges of γbw (the dimensionless distance between the rigid wall and the nearest bubble center), the interaction between the coalesced bubble and the rigid wall is divided into three types, i.e., "weak," "intermediate," and "strong." As γbw decreases, the contact point of the two axial jets migrates toward the wall. In "strong interaction" cases, only an upward jet towards the upper rigid wall forms and a secondary jet with a larger width appears at the base of the first jet. The collapsing coalesced bubble in a toroidal form splits into many smaller bubbles due to the instabilities and presents as bubble clouds during the rebounding phase, which may lead to a weakened pressure wave because the focusing energy associated with the collapsing bubble is disintegrated.

The predictive value of drug-induced sleep endoscopy for CPAP titration in OSA patients.

PubMed

Lan, Ming-Chin; Hsu, Yen-Bin; Lan, Ming-Ying; Huang, Yun-Chen; Kao, Ming-Chang; Huang, Tung-Tsun; Chiu, Tsan-Jen; Yang, Mei-Chen

2017-12-15

The aim of this study was to identify possible upper airway obstructions causing a higher continuous positive airway pressure (CPAP) titration level, utilizing drug-induced sleep endoscopy (DISE). A total of 76 patients with obstructive sleep apnea (OSA) underwent CPAP titration and DISE. DISE findings were recorded using the VOTE classification system. Polysomnographic (PSG) data, anthropometric variables, and patterns of airway collapse during DISE were analyzed with CPAP titration levels. A significant association was found between the CPAP titration level and BMI, oxygen desaturation index (ODI), apnea-hypopnea index (AHI), and neck circumference (NC) (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively, by Spearman correlation). Patients with concentric collapse of the velum or lateral oropharyngeal collapse were associated with a significantly higher CPAP titration level (P < 0.001 and P = 0.043, respectively, by nonparametric Mann-Whitney U test; P < 0.001 and P = 0.004, respectively, by Spearman correlation). No significant association was found between the CPAP titration level and any other collapse at the tongue base or epiglottis. By analyzing PSG data, anthropometric variables, and DISE results with CPAP titration levels, we can better understand possible mechanisms resulting in a higher CPAP titration level. We believe that the role of DISE can be expanded as a tool to identify the possible anatomical structures that may be corrected by oral appliance therapy or surgical intervention to improve CPAP compliance.

Constraining high-energy neutrino emission from choked jets in stripped-envelope supernovae

NASA Astrophysics Data System (ADS)

Senno, Nicholas; Murase, Kohta; Mészáros, Peter

2018-01-01

There are indications that γ-ray dark objects such as supernovae (SNe) with choked jets, and the cores of active galactic nuclei may contribute to the diffuse flux of astrophysical neutrinos measured by the IceCube observatory. In particular, stripped-envelope SNe have received much attention since they are capable of producing relativistic jets and could explain the diversity in observations of collapsar explosions (e.g., gamma-ray bursts (GRBs), low-luminosity GRBs, and Type Ibc SNe). We use an unbinned maximum likelihood method to search for spatial and temporal coincidences between Type Ibc core-collapse SNe, which may harbor a choked jet, and muon neutrinos from a sample of IceCube up-going track-like events measured from May 2011–May 2012. In this stacking analysis, we find no significant deviation from a background-only hypothesis using one year of data, and are able to place upper limits on the total amount of isotropic equivalent energy that choked jet core-collapse SNe deposit in cosmic rays Script Ecr and the fraction of core-collapse SNe which have a jet pointed towards Earth fjet. This analysis can be extended with yet to be made public IceCube data, and the increased amount of optically detected core-collapse SNe discovered by wide field-of-view surveys such as the Palomar Transient Factory and All-Sky Automated Survey for Supernovae. The choked jet SNe/high-energy cosmic neutrino connection can be more tightly constrained in the near future.

Three-dimensional geophysical mapping of shallow water saturated altered rocks at Mount Baker, Washington: Implications for slope stability

USGS Publications Warehouse

Finn, Carol A.; Deszcz-Pan, Maria; Ball, Jessica L.; Bloss, Benjamin J.; Minsley, Burke J.

2018-01-01

Water-saturated hydrothermal alteration reduces the strength of volcanic edifices, increasing the potential for catastrophic sector collapses that can lead to far traveled and destructive debris flows. Intense hydrothermal alteration significantly lowers the resistivity and magnetization of volcanic rock and therefore hydrothermally altered rocks can be identified with helicopter electromagnetic and magnetic measurements. Geophysical models constrained by rock properties and geologic mapping show that intensely altered rock is restricted to two small (500 m diameter), >150 m thick regions around Sherman Crater and Dorr Fumarole Field at Mount Baker, Washington. This distribution of alteration contrasts with much thicker and widespread alteration encompassing the summits of Mounts Adams and Rainier prior to the 5600 year old Osceola collapse, which is most likely due to extreme erosion and the limited duration of summit magmatism at Mount Baker. In addition, the models suggest that the upper ~300 m of rock contains water which could help to lubricate potential debris flows. Slope stability modeling incorporating the geophysically modeled distribution of alteration and water indicates that the most likely and largest (~0.1 km3) collapses are from the east side of Sherman Crater. Alteration at Dorr Fumarole Field raises the collapse hazard there, but not significantly because of its lower slope angles. Geochemistry and analogs from other volcanoes suggest a model for the edifice hydrothermal system.

Distinct loci of lexical and semantic access deficits in aphasia: Evidence from voxel-based lesion-symptom mapping and diffusion tensor imaging.

PubMed

Harvey, Denise Y; Schnur, Tatiana T

2015-06-01

Naming pictures and matching words to pictures belonging to the same semantic category negatively affects language production and comprehension. By most accounts, semantic interference arises when accessing lexical representations in naming (e.g., Damian, Vigliocco, & Levelt, 2001) and semantic representations in comprehension (e.g., Forde & Humphreys, 1997). Further, damage to the left inferior frontal gyrus (LIFG), a region implicated in cognitive control, results in increasing semantic interference when items repeat across cycles in both language production and comprehension (Jefferies, Baker, Doran, & Lambon Ralph, 2007). This generates the prediction that the LIFG via white matter connections supports resolution of semantic interference arising from different loci (lexical vs semantic) in the temporal lobe. However, it remains unclear whether the cognitive and neural mechanisms that resolve semantic interference are the same across tasks. Thus, we examined which gray matter structures [using whole brain and region of interest (ROI) approaches] and white matter connections (using deterministic tractography) when damaged impact semantic interference and its increase across cycles when repeatedly producing and understanding words in 15 speakers with varying lexical-semantic deficits from left hemisphere stroke. We found that damage to distinct brain regions, the posterior versus anterior temporal lobe, was associated with semantic interference (collapsed across cycles) in naming and comprehension, respectively. Further, those with LIFG damage compared to those without exhibited marginally larger increases in semantic interference across cycles in naming but not comprehension. Lastly, the inferior fronto-occipital fasciculus, connecting the LIFG with posterior temporal lobe, related to semantic interference in naming, whereas the inferior longitudinal fasciculus (ILF), connecting posterior with anterior temporal regions related to semantic interference in comprehension. These neuroanatomical-behavioral findings have implications for models of the lexical-semantic language network by demonstrating that semantic interference in language production and comprehension involves different representations which differentially recruit a cognitive control mechanism for interference resolution. Copyright © 2015 Elsevier Ltd. All rights reserved.

Obstructive sleep apnea syndrome: An important piece in the puzzle of cardiovascular risk factors.

PubMed

Costa, Cátia; Santos, Beatriz; Severino, Davide; Cabanelas, Nuno; Peres, Marisa; Monteiro, Isabel; Leal, Margarida

2015-01-01

The obstructive sleep apnea syndrome (OSA) is a clinical entity characterized by recurring episodes of apnea and/or hypopnea during sleep, due to a total or partial collapse, respectively, of the upper airway. This collapse originates a set of pathophysiological changes that determine the appearance of several cardiovascular complications. OSA contributes for the development of hypertension, heart failure, arrhythmias and coronary heart disease. Nowadays it is recognized to be an important public health problem, taking into account not just its repercussions but also its prevalence, since the main risk factor for the disease is obesity, a growing problem worldwide, both in developed and developing countries. The present review summarizes the current knowledge about OSA, as regards its definition, pathophysiology, clinical manifestations, diagnosis, cardiovascular effects and treatment. Copyright © 2014 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

Venus - Landslide Deposits

NASA Technical Reports Server (NTRS)

1992-01-01

The Magellan spacecraft has observed remnant landslide deposits apparently resulting from the collapse of volcanic structures. This image, centered at 45.2 degrees south latitude, 201.4 degrees east longitude, shows a collapse deposit 70 kilometers (43 miles) across. The bright, highly textured deposit near the center of the image probably consists of huge blocks of fractured volcanic rock, many as large as several hundred meters across. A remnant of the volcano itself, about 20 kilometers (12.4 miles) across, is seen at the center of the image. The distorted radar appearance of the volcano is a result of extremely steep slopes on the 'scars' from which the landslide material originated. A field of numerous small volcanic domes can be seen in the northern half of the image. The bright irregular lineaments trending to the north-northwest are ridges caused by regional tectonic deformation of the upper layers of the Venusian crust.

Characteristics, extent and origin of hydrothermal alteration at Mount Rainier Volcano, Cascades Arc, USA: Implications for debris-flow hazards and mineral deposits

USGS Publications Warehouse

John, D.A.; Sisson, T.W.; Breit, G.N.; Rye, R.O.; Vallance, J.W.

2008-01-01

Hydrothermal alteration at Mount Rainier waxed and waned over the 500,000-year episodic growth of the edifice. Hydrothermal minerals and their stable-isotope compositions in samples collected from outcrop and as clasts from Holocene debris-flow deposits identify three distinct hypogene argillic/advanced argillic hydrothermal environments: magmatic-hydrothermal, steam-heated, and magmatic steam (fumarolic), with minor superimposed supergene alteration. The 3.8??km3 Osceola Mudflow (5600??y BP) and coeval phreatomagmatic F tephra contain the highest temperature and most deeply formed hydrothermal minerals. Relatively deeply formed magmatic-hydrothermal alteration minerals and associations in clasts include quartz (residual silica), quartz-alunite, quartz-topaz, quartz-pyrophyllite, quartz-dickite/kaolinite, and quartz-illite (all with pyrite). Clasts of smectite-pyrite and steam-heated opal-alunite-kaolinite are also common in the Osceola Mudflow. In contrast, the Paradise lahar, formed by collapse of the summit or near-summit of the edifice at about the same time, contains only smectite-pyrite and near-surface steam-heated and fumarolic alteration minerals. Younger debris-flow deposits on the west side of the volcano (Round Pass and distal Electron Mudflows) contain only low-temperature smectite-pyrite assemblages, whereas the proximal Electron Mudflow and a < 100??y BP rock avalanche on Tahoma Glacier also contain magmatic-hydrothermal alteration minerals that are exposed in the avalanche headwall of Sunset Amphitheater, reflecting progressive incision into deeper near-conduit alteration products that formed at higher temperatures. The pre-Osceola Mudflow alteration geometry is inferred to have consisted of a narrow feeder zone of intense magmatic-hydrothermal alteration limited to near the conduit of the volcano, which graded outward to more widely distributed, but weak, smectite-pyrite alteration within 1??km of the edifice axis, developed chiefly in porous breccias. The edifice was capped by a steam-heated alteration zone, most of which resulted from condensation of fumarolic vapor and oxidation of H2S in the unsaturated zone above the water table. Weakly developed smectite-pyrite alteration extended into the west and east flanks of the edifice, spatially associated with dikes that are localized in those sectors; other edifice flanks lack dikes and associated alteration. The Osceola collapse removed most of the altered core and upper east flank of the volcano, but intensely altered rocks remain on the uppermost west flank. Major conclusions of this study are that: (1) Hydrothermal-mineral assemblages and distributions at Mount Rainier can be understood in the framework of hydrothermal processes and environments developed from studies of ore deposits formed in analogous settings. (2) Frequent eruptions supplied sufficient hot magmatic fluid to alter the upper interior of the volcano hydrothermally, despite the consistently deep (??? 8??km) magma reservoir which may have precluded formation of economic mineral deposits within or at shallow depths beneath Mount Rainier. The absence of indicator equilibrium alteration-mineral assemblages in the debris flows that effectively expose the volcano to a depth of 1-1.5??km also suggests a low potential for significant high-sulfidation epithermal or porphyry-type mineral deposits at depth. (3) Despite the long and complex history of the volcano, intensely altered collapse-prone rocks were spatially restricted to near the volcano's conduit system and summit, and short distances onto the upper east and west flanks, due to the necessary supply of reactive components carried by ascending magmatic fluids. (4) Intensely altered rocks were removed from the summit, east flank, and edifice interior by the Osceola collapse, but remain on the upper west flank in the Sunset Amphitheater area and present a continuing collapse hazard. (5) Visually conspicuous rocks on the lower east and mid-to-lower

Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms

PubMed Central

Kubin, Leszek

2017-01-01

Upper airway muscles subserve many essential for survival orofacial behaviors, including their important role as accessory respiratory muscles. In the face of certain predisposition of craniofacial anatomy, both tonic and phasic inspiratory activation of upper airway muscles is necessary to protect the upper airway against collapse. This protective action is adequate during wakefulness, but fails during sleep which results in recurrent episodes of hypopneas and apneas, a condition known as the obstructive sleep apnea syndrome (OSA). Although OSA is almost exclusively a human disorder, animal models help unveil the basic principles governing the impact of sleep on breathing and upper airway muscle activity. This article discusses the neuroanatomy, neurochemistry, and neurophysiology of the different neuronal systems whose activity changes with sleep-wake states, such as the noradrenergic, serotonergic, cholinergic, orexinergic, histaminergic, GABAergic and glycinergic, and their impact on central respiratory neurons and upper airway motoneurons. Observations of the interactions between sleep-wake states and upper airway muscles in healthy humans and OSA patients are related to findings from animal models with normal upper airway, and various animal models of OSA, including the chronic-intermittent hypoxia model. Using a framework of upper airway motoneurons being under concurrent influence of central respiratory, reflex and state-dependent inputs, different neurotransmitters, and neuropeptides are considered as either causing a sleep-dependent withdrawal of excitation from motoneurons or mediating an active, sleep-related inhibition of motoneurons. Information about the neurochemistry of state-dependent control of upper airway muscles accumulated to date reveals fundamental principles and may help understand and treat OSA. PMID:27783860

The Evolution of Porosity During Weathering of Serpentinite and the Creation of Thin Regolith in the Appalachian Piedmont

NASA Astrophysics Data System (ADS)

Marcon, V.; Gu, X.; Brantley, S. L.

2017-12-01

Life on Earth relies on the breakdown of impermeable bedrock into porous weathered rock to release nutrients and open pathways for gases and fluids to move through the subsurface. Serpentinites, though rare, are found across the globe and often have thin soils. Few studies have evaluated how porosity, a first order control on weathering, evolves from unweathered serpentinite bedrock to the soil. In this study, we evaluated weathering of serpentinites from bedrock to soil along a ridgetop in Nottingham Park, PA. A suite of geochemical analyses were used to determine chemical and physical changes during weathering. We used neutron scattering to measure pores 2nm to 20 microns in size (referred to here as nanoporosity). As this serpentinite weathers, small pores ( 1nm in diameter) are occluded and total nanoporosity and pore connectivity decrease throughout the weathered rock. Specifically, total nanoporosity decreases from 10% in the unweathered parent material to 5% in the weathered rock. However, in the upper meter of the profile, total nanoporosity increases as Fe, Mg, Mn, Si, Ni, Cr, and V are depleted. Additionally, bulk density and strain calculations suggest total volume expansion throughout the weathered rock followed by volume collapse in the upper 0.5m of the profile. We propose that low temperature reactions alter olivine in the parent material to serpentine minerals at the parent-weathered rock interface, resulting in a volume expansion and the loss of nanopores 1-100nm in size in this weathered rock zone. Volume expansion has long been reported to occur during low temperature serpentinization. We also infer that this loss of porosity limits the infiltration of reactive meteoric fluids into the deeper rock material and restricts the depth of regolith development. Following low temperature serpentinization, serpentine minerals (e.g. antigorite and lizardite) dissolve higher in the weathered rock. Because serpentinite rocks lack a non-reactive mineral such as quartz to provide supportive skeleton in the regolith, dissolution ultimately leads to collapse in the upper meter of the profile. The evolution of porosity in this profile can help explain why serpentinite regolith is characteristically thin to non-existent in the Piedmont: thin regolith occurs because of porosity occlusion as well as collapse.

Multiple myeloma in an Amur tiger (Panthera tigris altaica)

PubMed Central

Lee, Alison M.; Guppy, Naomi; Bainbridge, John; Jahns, Hanne

2017-01-01

The Amur tiger (Panthera tigris altaica) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein electrophoresis revealed a monoclonal band in the β-globulin region. Necropsy demonstrated hemoabdomen, multifocal lytic bone marrow lesions, splenomegaly, and hemorrhagic hepatic nodules, with left medial lobe rupture. There were mutifocal hemorrhages in the subcutis, lung, epicardium, and intestinal mucosa. Histopathology demonstrated plasmacytoid cells infiltrating the bone marrow, liver and spleen, and circulating within blood vessels. On immunohistochemistry, cell infiltrates of the three tissues were positive for λ light chains, bone marrow infiltrates were positive for MUM-1 and bone marrow and spleen infiltrates were positive for CD20. These findings indicate that this animal died of hemoabdomen subsequent to multiple myeloma. This is the first time this disease has been reported in a tiger. PMID:29138744

Multiple myeloma in an Amur tiger (Panthera tigris altaica).

PubMed

Lee, Alison M; Guppy, Naomi; Bainbridge, John; Jahns, Hanne

2017-01-01

The Amur tiger ( Panthera tigris altaica ) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein electrophoresis revealed a monoclonal band in the β-globulin region. Necropsy demonstrated hemoabdomen, multifocal lytic bone marrow lesions, splenomegaly, and hemorrhagic hepatic nodules, with left medial lobe rupture. There were mutifocal hemorrhages in the subcutis, lung, epicardium, and intestinal mucosa. Histopathology demonstrated plasmacytoid cells infiltrating the bone marrow, liver and spleen, and circulating within blood vessels. On immunohistochemistry, cell infiltrates of the three tissues were positive for λ light chains, bone marrow infiltrates were positive for MUM-1 and bone marrow and spleen infiltrates were positive for CD20. These findings indicate that this animal died of hemoabdomen subsequent to multiple myeloma. This is the first time this disease has been reported in a tiger.

Singular Isothermal Disks and the Formation of Multiple Stars

NASA Technical Reports Server (NTRS)

Galli, Daniele; Shu, Frank H.; Laughlin, Gregory; Lizano, Susana; DeVincenzi, Donald (Technical Monitor)

2000-01-01

A crucial missing ingredient in previous theoretical studies of fragmentation is the inclusion of dynamically important levels of magnetic fields. As a minimal model for a candidate presursor to the formation of binary and multiple stars, we therefore consider the equilibrium configuration of isopedically magnetized, scale-free, singular isothermal disks, without the assumption of axial symmetry. We find that lopsided (M = 1) configurations exist at any dimensionless rotation rate, including zero. Multiple-lobed (M = 2, 3, 4, ...) configurations bifurcate from an underlying axisymmetric sequence at progressively higher dimensionless rates of rotation, but such nonaxisymmetric sequences always terminate in shockwaves before they have a chance to fission into separate bodies. We advance the hypothesis that binary and multiple star-formation from smooth (i.e., not highly turbulent) starting states that are supercritical but in unstable mechanical balance requires the rapid (i.e., dynamical) loss of magnetic flux at some stage of the ensuing gravitational collapse.

Donor lung assessment using selective pulmonary vein gases.

PubMed

Costa, Joseph; Sreekanth, Sowmyashree; Kossar, Alex; Raza, Kashif; Lederer, David J; Robbins, Hilary; Shah, Lori; Sonett, Joshua R; Arcasoy, Selim; D'Ovidio, Frank

2016-11-01

Standard donor lung assessment relies on imaging, challenge gases and subjective interpretation of bronchoscopic findings, palpation and visual assessment. Central gases may not accurately represent true quality of the lungs. We report our experience using selective pulmonary vein gases to corroborate the subjective judgement. Starting, January 2012, donor lungs have been assessed by intraoperative bronchoscopy, palpation and visual judgement of lung collapse upon temporary disconnection from ventilator, central gases from the aorta and selective pulmonary vein gases. Partial pressure of oxygen (pO 2 ) <300 mmHg on FiO 2 of 1.0 was considered low. The results of the chest X-ray and last pO 2 in the intensive care unit were also collected. Post-transplant primary graft dysfunction and survival were monitored. To date, 259 consecutive brain-dead donors have been assessed and 157 transplants performed. Last pO 2 in the intensive care unit was poorly correlated with intraoperative central pO 2 (Spearman's rank correlation r s = 0.29). Right inferior pulmonary vein pO 2 was associated (Mann-Whitney, P < 0.001) with findings at bronchoscopy [clean: median pO 2 443 mmHg (25th-75th percentile range 349-512) and purulent: 264 mmHg (178-408)]; palpation [good: 463 mmHg (401-517) and poor: 264 mmHg (158-434)] and visual assessment of lung collapse [good lung collapse: 429 mmHg (320-501) and poor lung collapse: 205 mmHg (118-348)]. Left inferior pulmonary pO 2 was associated (P < 0.001) with findings at bronchoscopy [clean: 419 mmHg (371-504) and purulent: 254 mmHg (206-367)]; palpation [good: 444 mmHg (400-517) and poor 282 mmHg (211-419)] and visual assessment of lung collapse [good: 420 mmHg (349-496) and poor: 246 mmHg (129-330)]. At 72 h, pulmonary graft dysfunction 2 was in 21/157 (13%) and pulmonary graft dysfunction 3 in 17/157 (11%). Ninety-day and 1-year mortalities were 6/157 (4%) and 13/157 (8%), respectively. Selective pulmonary vein gases provide corroborative objective support to the findings at bronchoscopy, palpation and visual assessment. Central gases do not always reflect true function of the lungs, having high false-positive rate towards the individual lower lobe gas exchange. Objective measures of donor lung function may optimize donor surgeon assessment, allowing for low pulmonary graft dysfunction rates and low 90-day and 1-year mortality. © The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

[Tumour of the right lung vertex that produced a Pancoast syndrome: description of a case].

PubMed

Hermida Péreza, J A; Bermejo Hernández, A; Hernández Guerra, J S; Arroyo Diaz, R

2012-03-01

We describe a clinical case of an 80 year-old woman, with a history of Alzheimer's disease, who presented with right shoulder pain, numbness and decreased strength in the right arm, with right eye ptosis, cough and dysphagia. The chest X-Ray and thoracic-abdominal computed tomography scan showed a large mass in the upper lobe and apex of the right lung, supraclavicular metastatic lymph nodes. In the fine needle aspiration biopsy: poorly differentiated non-small cell carcinoma. She was referred to Oncology to start chemotherapy treatment.

Air Vehicle Integration and Technology Research (AVIATR). Delivery Order 0002: Condition-Based Maintenance Plus Structural Integrity (CBM+SI) Strategy Development

DTIC Science & Technology

2010-11-01

material. The rubber is laser -etched with rows of tiny, interconnected channels or galleries, to which air pressure is applied. Any propagating crack... clad one side. The Upper Lobe has a radius of approximately 85” (compound curvature) in the region of interest. As stated previously, the skin is...7079-T6 sheet; clad one side with a varying thickness of 0.050” to 0.071” (varies according to stability requirements for compression combined with

PubMed Central

PASSALI, D.; CARUSO, G.; ARIGLIANO, L.C.; PASSALI, F.M.; BELLUSSI, L.

2012-01-01

SUMMARY Obstructive sleep apnoea syndrome (OSAS) results from upper airway collapse during sleep. It represents an increasingly recognized pathology associated with many diseases. Herein, we describe a database for patients with OSAS. This has different goals: to facilitate good uniformity in clinical assessment, to allow the use of the application even by non-ENT specialists, to evaluate the results of medical and/or surgical treatments and to enable a statistical meta-analysis derived from the data collected in many OSAS medical centres. PMID:23093815

Acid rain research program. Annual progress report, September 1975--June 1976

DOE Office of Scientific and Technical Information (OSTI.GOV)

Evans, L.S.; Raynor, G.S.

1976-09-01

The aims of the research program are: (a) to observe the minimum threshold dose of simulated acid rain to produce visual and histological effects on plant foliage, (b) approach threshold limits of simulated sulfate acid rain that affect plant growth and reproduction, and (c) to measure chemical and meteorological parameters of incident rain. Acute leaf injury to several plant species resulted from exposure of foliage to simulated sulfate acid rain of pH level 2.3 to 2.9. Only slight injury occurred at 3.1. Scanning electron micrographs showed that injury to upper leaf surfaces occurred mostly at the base of trichomes (leafmore » hairs) and near stomata. An association of lesion development near vascular tissue was also noted. Histologically, lesions are characterized by an initial collapse of the epidermis with eventual lysis and collapse of more internal leaf tissues on the upper leaf surface of pinto beans which complemented detailed descriptions of visual lesion development after daily exposures to simulated rain. Initial experiments with gametophytes of Pteridium aquilinum show that reproduction of this fern species is very sensitive to solutions of pH 5.2 while vegetative development is not affected at pH levels of 2.2. Initial rain samples from the sequential sampler have been obtained. Initial portions of rain events exhibit a pH near 3.0 in some cases. More complete chemical analyses are anticipated.« less

Positron Emission Tomography With 18F-Fluorodeoxyglucose in Patients With Sickle Cell Acute Chest Syndrome

PubMed Central

de Prost, Nicolas; Sasanelli, Myriam; Deux, Jean-François; Habibi, Anoosha; Razazi, Keyvan; Galactéros, Frédéric; Meignan, Michel; Maître, Bernard; Brun-Buisson, Christian; Itti, Emmanuel; Dessap, Armand Mekontso

2015-01-01

Abstract The acute chest syndrome (ACS) is the main cause of mortality among adult patients with sickle cell disease (SCD). Its pathophysiology is still unclear. Using positron emission tomography (PET) with 18F-fluorodeoxyglucose [18F-fluorodeoxyglucose (18F-FDG)], we explored the relationship between regional lung density and lung metabolism, as a reflection of lung neutrophilic infiltration during ACS. Patients were prospectively enrolled in a single-center study. Dual modality chest PET/computed tomography (CT) scans were performed, with 18F-FDG emission scans for quantification of regional 18F-FDG uptake and CT scans with radiocontrast agent to check for pulmonary artery thrombosis. Regional lung 18F-FDG uptake was quantified in ACS patients and in SCD patients without ACS (SCD non-ACS controls). Maximal (SUVmax) and mean (SUVmean) standardized uptake values were computed. Seventeen patients with ACS (mean age 28.3 ± 6.4 years) were included. None died nor required invasive mechanical ventilation. The main lung opacity on CT scans was lower lobe consolidation. Lungs of patients with ACS exhibited higher SUVmax than those of SCD non-ACS controls (2.5 [2.1–2.9] vs 0.8 [0.6–1.0]; P < 0.0001). Regional SUVmax and SUVmean was higher in lower than in upper lobes of ACS patients (P < 0.001) with a significant correlation between lung density and SUVmax (R2 = 0.78). SUVmean was higher in upper lobes of ACS patients than in lungs of SCD non-ACS controls (P < 0.001). Patients with SUVmax >2.5 had longer intensive care unit (ICU) stay than others (7 [6–11] vs 4 [3–6] days; P = 0.016). Lungs of patients with ACS exhibited higher 18F-FDG uptake than SCD non-ACS controls. Lung apices had normal aeration and lower 18F-FDG uptake than lung bases, but higher 18F-FDG uptake than lungs of SCD non-ACS controls. Patients with higher lung 18F-FDG uptake had longer ICU stay than others. PMID:25950690

Postural Effects on Pharyngeal Protective Reflex Mechanisms

PubMed Central

Malhotra, Atul; Trinder, John; Fogel, Robert; Stanchina, Michael; Patel, Sanjay R.; Schory, Karen; Kleverlaan, Darci; White, David P.

2012-01-01

Study Objectives Pharyngeal muscle dilators are important in obstructive sleep apnea pathogenesis because the failure of protective reflexes involving these muscles yields pharyngeal collapse. Conflicting results exist in the literature regarding the responsiveness of these muscles during stable non-rapid eye movement sleep. However, variations in posture in previous studies may have influenced these findings. We hypothesized that tongue protruder muscles are maximally responsive to negative pressure pulses during supine sleep, when posterior tongue displacement yields pharyngeal occlusion. Design We studied all subjects in the supine and lateral postures during wakefulness and stable non-rapid eye movement sleep by measuring genioglossus and tensor palatini electromyograms during basal breathing and following negative pressure pulses. Setting Upper-airway physiology laboratory of Sleep Medicine Division, Brigham and Women’s Hospital. Subjects/Participants 17 normal subjects. Measurements and Results We observed an increase in genioglossal responsiveness to negative pressure pulses in sleep as compared to wakefulness in supine subjects (3.9 percentage of maximum [%max] ± 1.1 vs 4.4 %max ± 1.0) but a decrease in the lateral decubitus position (4.1 %max ± 1.0 vs 1.5 %max ± 0.4), the interaction effect being significant. Despite this augmented reflex, collapsibility, as measured during negative pressure pulses, increased more while subjects were in the supine position as compared with the lateral decubitus position. While the interaction between wake-sleep state and position was also significant for the tensor palatini, the effect was weaker than for genioglossus, although, for tensor palatini, baseline activity was markedly reduced during non-rapid eye movement sleep as compared with wakefulness. Conclusions We conclude that body posture does have an important impact on genioglossal responsiveness to negative pressure pulses during non-rapid eye movement sleep. We speculate that this mechanism works to prevent pharyngeal occlusion when the upper airway is most vulnerable to collapse eg, during supine sleep. PMID:15532204

Ground deformation at Merapi Volcano, Java, Indonesia: distance changes, June 1988-October 1995

USGS Publications Warehouse

Young, K.D.; Voight, B.; ,; ,; ,; Casadevall, T.J.

2000-01-01

Edifice deformations are reported here for the period 1988–1995 at Merapi volcano, one of the most active and dangerous volcanoes in Indonesia. The study period includes a major resumption in lava effusion in January 1992 and a major dome collapse in November 1994. The data comprise electronic distance measurements (EDM) on a summit trilateration network, slope distance changes measured to the upper flanks, and other data collected from 1988 to 1995. A major consequence of this study is the documentation of a significant 4-year period of deformation precursory to the 1992 eruption. Cross-crater strain rates accelerated from less than 3×10−6/day between 1988 and 1990 to more than 11×10−6/day just prior to the January 1992 activity, representing a general, asymmetric extension of the summit during high-level conduit pressurization. After the vent opened and effusion of lava resumed, strain occurred at a much-reduced rate of less than 2×10−6/day. EDM measurements between lower flank benchmarks and the upper edifice indicate displacements as great as 1 m per year over the four years before the 1992 eruption. The Gendol breach, a pronounced depression formed by the juxtaposition of old lava coulées on the southeast flank, functioned as a major displacement discontinuity. Since 1993, movements have generally not exceeded the 95% confidence limits of the summit network. Exceptions to this include 12 cm outward movement for the northwest crater rim in 1992–1993, probably from loading by newly erupted dome lava, and movements as much as 7 cm on the south flank between November 1994 and September 1995. No short-term precursors were noted before the November 1994 lava dome collapse, but long-term adjustments of crater geometry accompanied lava dome growth in 1994. Short-term 2-cm deflation of the edifice occurred following the November 1994 dome collapse.

Uranium potential of the Burro Canyon Formation in western Colorado

USGS Publications Warehouse

Craig, L.C.

1982-01-01

The Burro Canyon Formation of Early Cretaceous age overlies the Morrison Formation (Late Jurassic) and underlies the Dakota Sandstone (Late Cretaceous) over most of southeastern Utah and southwestern Colorado. It consists mainly of alternating beds of fluvial sandstone and overbank mudstone with sandstone dominating in the lower part of the formation and mudstone in the upper part. At the outcrop, the sandstones in the formation exhibit almost all the characteristics that are considered favorable for the occurrence of sandstone-type uranium deposits, but only a few small deposits have been discovered in the Colorado-Utah area. The major deficiency of the Burro Canyon in these outcrop areas is the absence of a reductant such as carbonaceous debris, humic or humate materials, or pyrite. Reductants were probably removed during a period of extensive oxidation at the time of deposition and during a subsequent erosional episode prior to deposition of the Dakota Sandstone. The formation reaches a lobate, inexactly located eastern margin that extends from near Meeker, Colorado, southward through the Piceance basin to near Aztec, New Mexico, in the northwestern part of the San Juan Basin. Along much of this distance, the formation is in the subsurface and has been penetrated by only a few drill holes. Along this eastern margin, the lobes project eastward where fluvial distributary streams built minor alluvial fans of relatively high-energy deposits out from the main axis of Burro Canyon stream deposition. The lower and distal reaches of these lobes may have survived the period of post depositional erosion and oxidation in a reduced condition because of low relief and the protection of a high water table. If so, the peripheral and distal parts of these lobes may have retained the precipitants necessary to form a uranium deposit. Two of the lobes extend into the southwest margin of the Piceance Basin and are considered the possible location of uranium deposits. Two additional lobes extend into the northwestern part of the San Juan Basin but have not been evaluated in this study.

[A case of lung cancer producing granulocyte colony-stimulating factor with a significantly high uptake in the bones observed by a FDG-PET scan].

PubMed

Hidaka, Dai; Koshizuka, Hiroaki; Hiyama, Junichiro; Nakatsubo, Seita; Ikeda, Koutarou; Hayashi, Akihiro; Fujii, Akiko; Sawamoto, Ryouko; Misumi, Yukihiro; Miyagawa, Yousuke

2009-03-01

A 57-year-old man complaining of right shoulder pain was admitted. Chest enhanced CT scanning showed a mass shadow in the right upper lobe with chest wall invasion. The laboratory data on admission showed marked leukocytosis. A CT-guided lung biopsy was performed, and a histological examination of the biopsy specimen showed a spindle cell type pleomorphic carcinoma. Immunohistochemistry staining using an anti-granulocyte colony-stimulating factor (G-CSF) monoclonal antibody demonstrated many tumor cells containing G-CSF as well as an increased level of serum G-CSF. The diagnosis was determined to be lung cancer producing G-CSF. FDG-PET scanning showed a significantly high uptake in the right upper field and the bones throughout the body. After chemoradiation therapy, the patient underwent a right upper lobectomy with a chest wall resection. Since then, the leukocytosis and the high level of serum G-CSF normalized and the high uptake in the bones disappeared in the FDG-PET scan.

Ice stream behaviour in the western sector of the North Sea during the end of the last glacial cycle

NASA Astrophysics Data System (ADS)

Roberts, David; Evans, David; Clark, Chris; Bateman, Mark; Livingstone, Stephen; Medialdea, Alicia; Cofaigh, Colm O.; Grimoldi, Elena; Callard, Louise; Dove, Dayton; Stewart, Heather; Davies, Bethan; Chiverell, Richard

2016-04-01

During the last glacial cycle the East coast of the UK was overrun by the British-Irish Ice Sheet (BIIS) flowing eastwards and southwards. In recent years it has become evident that several ice streams including the Tweed, Tyne, and Stainmore Gap ice streams, as well as the late stage North Sea Lobe (NSL), all played a role in shaping the glacial landscape during this period, but understanding the flow phasing of these ice streams during advance and collapse has proved challenging. Here we present new data from the seafloor collected during recent work undertaken by the Britice Chrono and Glanam project teams during cruise JC123 in the North Sea. Sub-bottom seafloor data together with new swath data clearly show that the final phases of the collapse of the NSL were controlled by ice sourced from the Firth of Forth ice stream which deglaciated in a NNW trajectory. Other ice streams being fed from the west (e.g. Stainmore, Tyne, Tweed) were not influential in final phase ice retreat from the southern North Sea. The Forth ice imprint is characterised by several grounding zone/till wedges marking dynamic, oscillatory retreat of the ice as it retreated along an offshore corridor between North Yorkshire and Northumberland. Repeated packages of tills, ice marginal and glaciomarine sediments, which drape glacially scoured bedrock terrain and drumlins along this corridor, point to marine inundation accompanying ice retreat. New TCN ages suggest decoupling of the Tyne Gap ice stream and NSL between 17.8 and 16.5 ka and this coincides with rapid, regional collapse of the NSL between 17.2 and 16.0 ka along the Yorkshire and Durham coasts (new OSL ages; Britice Chrono). Hence, both the central and northern sectors of the BIIS were being strongly influenced by marine margin instability during the latter phases of the last glacial cycle.

Geomagnetic responses to the solar wind and the solar activity

NASA Technical Reports Server (NTRS)

Svalgaard, L.

1975-01-01

Following some historical notes, the formation of the magnetosphere and the magnetospheric tail is discussed. The importance of electric fields is stressed and the magnetospheric convection of plasma and magnetic field lines under the influence of large-scale magnetospheric electric fields is outlined. Ionospheric electric fields and currents are intimately related to electric fields and currents in the magnetosphere and the strong coupling between the two regions is discussed. The energy input of the solar wind to the magnetosphere and upper atmosphere is discussed in terms of the reconnection model where interplanetary magnetic field lines merge or connect with the terrestrial field on the sunward side of the magnetosphere. The merged field lines are then stretched behind earth to form the magnetotail so that kinetic energy from the solar wind is converted into magnetic energy in the field lines in the tail. Localized collapses of the crosstail current, which is driven by the large-scale dawn/dusk electric field in the magnetosphere, divert part of this current along geomagnetic field lines to the ionosphere, causing substorms with auroral activity and magnetic disturbances. The collapses also inject plasma into the radiation belts and build up a ring current. Frequent collapses in rapid succession constitute the geomagnetic storm.

Viscous flow past a collapsible channel as a model for self-excited oscillation of blood vessels.

PubMed

Tang, Chao; Zhu, Luoding; Akingba, George; Lu, Xi-Yun

2015-07-16

Motivated by collapse of blood vessels for both healthy and diseased situations under various circumstances in human body, we have performed computational studies on an incompressible viscous fluid past a rigid channel with part of its upper wall being replaced by a deformable beam. The Navier-Stokes equations governing the fluid flow are solved by a multi-block lattice Boltzmann method and the structural equation governing the elastic beam motion by a finite difference method. The mutual coupling of the fluid and solid is realized by the momentum exchange scheme. The present study focuses on the influences of the dimensionless parameters controlling the fluid-structure system on the collapse and self-excited oscillation of the beam and fluid dynamics downstream. The major conclusions obtained in this study are described as follows. The self-excited oscillation can be intrigued by application of an external pressure on the elastic portion of the channel and the part of the beam having the largest deformation tends to occur always towards the end portion of the deformable wall. The blood pressure and wall shear stress undergo significant variations near the portion of the greatest oscillation. The stretching motion has the most contribution to the total potential elastic energy of the oscillating beam. Copyright © 2015 Elsevier Ltd. All rights reserved.

Sickle cell crisis in the adult: chest radiographic findings and comparison with pediatric sickle cell disease.

PubMed

Miller, J A; Hinrichs, C R

2001-02-01

With the advent of improved therapy, an increasing proportion of individuals suffering from sickle cell disease (SCD) are surviving into adulthood. In contrast to children, little has been documented concerning the typical radiographic findings in adults presenting with sickle cell crises (SCC). We describe the chest radiographic (CXR) manifestations of adults with SCD presenting in SSC, correlated to hemoglobin (Hb) values, and compare them to those of the pediatric sickle cell population. The chest radiographs of 66 consecutive adults presenting to our emergency department complaining of symptoms consistent with acute SCC were retrospectively reviewed over a 12-month period. The radiographic findings were correlated with admission Hb values and compared with those of 50 children with known SCD presenting with SCC. Chi square analysis revealed no significant difference between the cardiovascular and bony findings in the adults and in those of the pediatric controls (p > 0.08-p > 1.0). However, one important difference in the two cohorts was that upper lobe infiltrates occurred exclusively in the pediatric group (p = 0.06). There was a statistically significant (p < 0.05) difference in cardiovascular and skeletal abnormalities between adults with Hb above and below the mean (8.2 g/dL). The radiographic features of adults presenting in acute SCCs are similar to those of children. Although the chest radiograph is often normal, in decreasing frequency, cardiovascular abnormalities, pneumonia sparing the upper lobes, and aseptic osteonecrosis of the shoulders and spine are not uncommon. There is a significant relationship, however, between cardiovascular abnormalities and Hb levels.

OCT imaging in chronic obstructive pulmonary disease

NASA Astrophysics Data System (ADS)

Ohtani, K.; Lopez Lisbona, R. M.; Lee, A. M. D.; Hyun, C.; Shaipanich, T.; McWilliams, A.; Lane, P.; Coxson, H. O.; MacAulay, C.; Lam, S.

2013-03-01

Introduction: A recent ex-vivo study using micro-CT in patients with chronic obstructive pulmonary disease (COPD) showed that narrowing and disappearance of small conducting airways precedes the onset of emphysematous destruction in COPD. Until recently, the airway remodeling process could not be studied in detail in-vivo. In this study, we investigated the repeatability of navigating an Optical Coherence Tomography (OCT) catheter to image the same airways in smokers with and without COPD. Method: OCT imaging was performed by inserting the catheter through a sub-segmental airway to a small bronchiole. Three-dimensional OCT imaging of 5 cm of airway segments was obtained. The catheter was removed and reinsertion into the same airway was attempted. The number of airway generations and quantitative measurements of the airway wall area were investigated. Results: Sixty-three airways in 30 subjects were analyzed. Repeated insertion into the same airway was observed at 53.8 %, 92.3% and 70.8% of the time in the upper, middle and lower lobes respectively. The percentage differences of paired measurements of airway wall area between matched and unmatched airways in bronchioles were 5.8 +/- 4.6 % and 7.3 +/- 5.4 % respectively Conclusions: Repeated OCT imaging of airways is possible in the majority of cases except in the upper lobes. For airways that are not completely matched, some of the airway segments can still be used for comparison by careful alignment of the airway. OCT may be a useful method to study the remodeling process in small airways and the effect of therapeutic intervention.

Restrictive allograft syndrome after lung transplantation: new radiological insights.

PubMed

Dubbeldam, Adriana; Barthels, Caroline; Coolen, Johan; Verschakelen, Johny A; Verleden, Stijn E; Vos, Robin; Verleden, Geert M; De Wever, Walter

2017-07-01

To describe the CT changes in patients with restrictive allograft syndrome (RAS) after lung transplantation, before and after clinical diagnosis. This retrospective study included 22 patients with clinical diagnosis of RAS. Diagnosis was based on a combination of forced expiratory volume (FEV1) decline (≥20 %) and total lung capacity (TLC) decline (≥10 %). All available CT scans after transplantation were analyzed for the appearance and evolution of lung abnormalities. In 14 patients, non-regressing nodules and reticulations predominantly affecting the upper lobes developed an average of 13.9 months prior to the diagnosis of RAS. Median graft survival after onset of non-regressing abnormalities was 33.5 months, with most patients in follow-up (9/14). In eight patients, a sudden appearance of diffuse consolidations mainly affecting both upper and lower lobes was seen an average of 2.8 months prior to the diagnosis of RAS. Median graft survival was 6.4 months after first onset of non-regressing abnormalities, with graft loss in most patients (6/8). RAS has been previously described as a homogenous group. However, our study shows two different groups of RAS-patients: one with slow progression and one with fast progression. The two groups show different onset and progression patterns of CT abnormalities. • RAS is the newest discovered form of chronic lung allograft dysfunction (CLAD). • RAS is not a homogenous group, as survival varies greatly between patients. • In this study, we see two different CT onset and progression patterns. • These two different CT patterns also correlate with a different survival rate.

Controls on the quality of Miocene reservoirs, southern Gulf of Mexico

NASA Astrophysics Data System (ADS)

Gutiérrez Paredes, Hilda Clarisa; Catuneanu, Octavian; Hernández Romano, Ulises

2018-01-01

An investigation was conducted to determine the main controls on the reservoir quality of the middle and upper Miocene sandstones in the southern Gulf of Mexico based on core descriptions, thin section petrography and petrophysical data; as well as to explore the possible link between the sequence stratigraphic framework, depositional facies and diagenetic alterations. The Miocene deep marine sandstones are attributed to the falling-stage, lowstand, and transgressive systems tracts. The middle Miocene falling-stage systems tract includes medium-to very fine-grained, and structureless sandstones deposited in channels and frontal splays, and muddy sandstones, deposited in lobes of debrites. The lowstand and transgressive systems tracts consist of medium-to very fine-grained massive and normally graded sandstones deposited in channel systems within frontal splay complexes. The upper Miocene falling-stage systems tract includes medium-to coarse-grained, structureless sandstones deposited in channel systems and frontal splay, as well as lobes of debrites formed by grain flows and hybrid-flow deposits. The lowstand and transgressive systems tracts include fine-grained sandstones deposited in overbank deposits. The results reveal that the depositional elements with the best reservoir quality are the frontal splays deposited during the falling-stage system tracts. The reservoir quality of the Miocene sandstones was controlled by a combination of depositional facies, sand composition and diagenetic factors (mainly compaction and calcite cementation). Sandstone texture, controlled primarily by depositional facies appears more important than sandstone composition in determining reservoir quality; and compaction was more important than cementation in porosity destruction. Compaction was stopped, when complete calcite cementation occurred.

Upper crustal densities derived from sea floor gravity measurements: Northern Juan De Fuca Ridge

USGS Publications Warehouse

Holmes, Mark L.; Johnson, H. Paul

1993-01-01

A transect of sea floor gravity stations has been analyzed to determine upper crustal densities on the Endeavour segment of the northern Juan de Fuca Ridge. Data were obtained using ALVIN along a corridor perpendicular to the axis of spreading, over crustal ages from 0 to 800,000 years. Calculated elevation factors from the gravity data show an abrupt increase in density with age (distance) for the upper 200 m of crust. This density change is interpreted as a systematic reduction in bulk porosity of the upper crustal section, from 23% for the axial ridge to 10% for the off-axis flanking ridges. The porosity decrease is attributed to the collapse and filling of large-scale voids as the abyssal hills move out of the crustal formation zone. Forward modeling of a plausible density structure for the near-axis region agrees with the observed anomaly data only if the model includes narrow, along-strike, low-density regions adjacent to both inner and outer flanks of the abyssal hills. The required low density zones could be regions of systematic upper crustal fracturing and faulting that were mapped by submersible observers and side-scan sonar images, and whose presence was suggested by the distribution of heat flow data in the same area.

Isotropic neutrino flux from supernova explosions in the universe

NASA Astrophysics Data System (ADS)

Petkov, V. B.

2018-01-01

Neutrinos of all types are emitted from the gravitational collapse of massive star cores, and have been amassed in the Universe throughout the history of evolution of galaxies. The isotropic and stable flux of these neutrinos is a source of information on the spectra of neutrinos from individual supernovae and on their redshift distribution. The prospects for detecting the isotropic neutrino flux with the existing and upcoming experimental facilities and the current upper limits are discussed in this paper.

On the Maximum Mass of Accreting Primordial Supermassive Stars

NASA Astrophysics Data System (ADS)

Woods, T. E.; Heger, Alexander; Whalen, Daniel J.; Haemmerlé, Lionel; Klessen, Ralf S.

2017-06-01

Supermassive primordial stars are suspected to be the progenitors of the most massive quasars at z ˜ 6. Previous studies of such stars were either unable to resolve hydrodynamical timescales or considered stars in isolation, not in the extreme accretion flows in which they actually form. Therefore, they could not self-consistently predict their final masses at collapse, or those of the resulting supermassive black hole seeds, but rather invoked comparison to simple polytropic models. Here, we systematically examine the birth, evolution, and collapse of accreting, non-rotating supermassive stars under accretion rates of 0.01-10 M ⊙ yr-1 using the stellar evolution code Kepler. Our approach includes post-Newtonian corrections to the stellar structure and an adaptive nuclear network and can transition to following the hydrodynamic evolution of supermassive stars after they encounter the general relativistic instability. We find that this instability triggers the collapse of the star at masses of 150,000-330,000 M ⊙ for accretion rates of 0.1-10 M ⊙ yr-1, and that the final mass of the star scales roughly logarithmically with the rate. The structure of the star, and thus its stability against collapse, is sensitive to the treatment of convection and the heat content of the outer accreted envelope. Comparison with other codes suggests differences here may lead to small deviations in the evolutionary state of the star as a function of time, that worsen with accretion rate. Since the general relativistic instability leads to the immediate death of these stars, our models place an upper limit on the masses of the first quasars at birth.

Emergency surgery for lung cancer with abscess formation after transbronchial biopsy.

PubMed

Takanashi, Yusuke; Miyashita, Koichi; Tajima, Shogo; Hayakawa, Takamitsu; Neyatani, Hiroshi; Funai, Kazuhito

2017-03-01

Abscess formation in lung cancer after transbronchial biopsy (TBB) is a rare complication with no standard consensus on a coping strategy or prophylaxis. We describe an instructive case of lung cancer which developed into an abscess after TBB. An 80-year-old man with poorly controlled diabetes mellitus underwent TBB for diagnosing a mass lesion in the left upper lobe. The TBB specimen confirmed a diagnosis of lung cancer, and he was scheduled for radical surgery. However, the tumour was revealed to have progressed into an enlarged abscess 24 days after TBB. Prompt use of meropenem failed to relieve the infection, hence we performed emergency left upper lobectomy. Poorly controlled diabetes mellitus was considered to be a risk for the formation of a tumour abscess after TBB. It was difficult to control the infection with conservative treatment using antibiotics; emergency surgical resection was considered to be the safest strategy for recovery.

New insight into the Upper Mantle Structure Beneath the Pacific Ocean Using PP and SS Precursors

NASA Astrophysics Data System (ADS)

Gurrola, H.; Rogers, K. D.

2013-12-01

The passing of the EarthScope Transportable array has provided a dense data set that enabled beam forming of SS and PP data that resultes in improved frequency content to as much a 1 Hz in the imaging of upper mantle structure. This combined with the application of simultaneous iterative deconvolution has resulted in images to as much as 4 Hz. The processing however results in structure being averaged over regions of 60 to 100 km in radius. This is becomes a powerful new tool to image the upper mantle beneath Oceanic regions where locating stations is expensive and difficult. This presentation will summarize work from a number of regions as to new observations of the upper mantle beneath the Pacific and Arctic Oceans. Images from a region of the Pacific Ocean furthest from hot spots or subduction zones (we will refer to this as the 'reference region'). show considerable layering in the upper mantle. The 410 km discontinuity is always imaged using these tools and appears to be a very sharp boundary. It does usually appear as an isolated positive phase. There appears to be a LAB at ~100 km as expected but there is a strong negative phase at ~ 200 km with a positive phase 15 km deeper. This is best explained as a lens of partial melt as expected for this depth based on the geothermal gradient. If so this should be a low friction point and so we would expect it to accommodate plate motion. Imaging of the Aleutian subduction zone does show the 100 km deep LAB as it descends but this 200 km deep horizon appears as a week descending positive anomaly without the shallower negative pulse. In addition to the 410, 100 and 200 km discontinuities there are a number of paired anomalies, between the 200 and 400 km depths, with a negative pulse 15 to 20 km shallower then the positive pulse. We do not believe these are side lobes or we would see side lobes on the 100 km and 410 km discontinuities. We believe these to be the result of friction induced partial melt along zones of critical failure to accommodate differential mantle flow with depth. The paired layers disappear beneath the Hawaiian Island chain. We believe heat from the hot spot warms the mantle beneath the Hawaiian island chain so flow is more easily accommodated. As a result the lenses of melt disappear in the region near hot spots.

Ichnology of fine-grained mixed carbonate-siliciclastic turbidites, Wood River Formation, Pennsylvanian-Permian south-central Idaho

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burton, B.R.; Link, P.K.

1991-06-01

In south-central Idaho, the Wood River Formation (Pennsylvanian-Permian) contains a stratigraphic megacycle over 2,000 m thick that is composed of fine-grained mixed carbonate-siliciclastic turbidites. Complete and partial (Bouma) turbidite structural sequences in these rocks are arranged in upward thinning cycles 15 to 30 m thick in which top-cut-out (Ta-c) turbidite facies in the lower part grade vertically into base-cut-out (Td-f) turbidites in the upper part. These cycles are interpreted to represent the autocyclic lateral migration of turbidite lobes. A mixed trace fossil assemblage of pascichnia and fordinichnia are present in these rocks and can be separated into pre-depositional and post-turbiditemore » ichnocoenoses. Quiet-water, pre-turbidite deposits are dark-colored, laminated, and carbonaceous, and represent anoxic to dysoxic inter-turbidite basinal conditions; they contain only Chondrites traces. Turbidity currents introduced oxygenated bottom water which fostered the temporary development of a post-turbidite ichnocoenose of pascichnia which is best developed in the medial portion of turbidite beds and lobes. Trace fossil tiering shows that a post-turbidite ichnocoenose of fodinichnia also developed, and persisted after the disappearance of pascichnia. Animals that produced the fodinichnial traces probably were part of an autochthonous benthic fauna rather than a short-lived allochthonous fauna. They may have migrated with the slowly avulsing turbidite lobes and exploited allochthonous oxygen and the carbonaceous food supply.« less

Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study.

PubMed

Vollmar, Christian; O'Muircheartaigh, Jonathan; Barker, Gareth J; Symms, Mark R; Thompson, Pamela; Kumari, Veena; Duncan, John S; Janz, Dieter; Richardson, Mark P; Koepp, Matthias J

2011-06-01

Juvenile myoclonic epilepsy is the most frequent idiopathic generalized epilepsy syndrome. It is characterized by predominant myoclonic jerks of upper limbs, often provoked by cognitive activities, and typically responsive to treatment with sodium valproate. Neurophysiological, neuropsychological and imaging studies in juvenile myoclonic epilepsy have consistently pointed towards subtle abnormalities in the medial frontal lobes. Using functional magnetic resonance imaging with an executive frontal lobe paradigm, we investigated cortical activation patterns and interaction between cortical regions in 30 patients with juvenile myoclonic epilepsy and 26 healthy controls. With increasing cognitive demand, patients showed increasing coactivation of the primary motor cortex and supplementary motor area. This effect was stronger in patients still suffering from seizures, and was not seen in healthy controls. Patients with juvenile myoclonic epilepsy showed increased functional connectivity between the motor system and frontoparietal cognitive networks. Furthermore, we found impaired deactivation of the default mode network during cognitive tasks with persistent activation in medial frontal and central regions in patients. Coactivation in the motor cortex and supplementary motor area with increasing cognitive load and increased functional coupling between the motor system and cognitive networks provide an explanation how cognitive effort can cause myoclonic jerks in juvenile myoclonic epilepsy. The supplementary motor area represents the anatomical link between these two functional systems, and our findings may be the functional correlate of previously described structural abnormalities in the medial frontal lobe in juvenile myoclonic epilepsy.

Prey capture behavior and kinematics of the Atlantic cownose ray, Rhinoptera bonasus.

PubMed

Sasko, Desirée E; Dean, Mason N; Motta, Philip J; Hueter, Robert E

2006-01-01

The structurally reinforced jaws of the cownose ray, Rhinoptera bonasus testify to this species' durophagous diet of mollusks, but seem ill-suited to the behaviors necessary for excavating such prey. This study explores this discordance by investigating the prey excavation and capture kinematics of R. bonasus. Based on the basal suction feeding mechanism in this group of fishes, we hypothesized a hydraulic method of excavation. As expected, prey capture kinematics of R. bonasus show marked differences relative to other elasmobranchs, relating to prey excavation and use of the cephalic lobes (modified anterior pectoral fin extensions unique to derived myliobatiform rays). Prey are excavated by repeated opening and closing of the jaws to fluidize surrounding sand. The food item is then enclosed laterally by the depressed cephalic lobes, which transport it toward the mouth for ingestion by inertial suction. Unlike in most sharks, upper jaw protrusion and mandibular depression are simultaneous. During food capture, the ray's spiracle, mouth, and gill slit movements are timed such that water enters only the mouth (e.g., the spiracle closes prior to prey capture and reopens immediately following). Indigestible parts are then hydraulically winnowed from edible prey portions, by mouth movements similar to those used in excavation, and ejected through the mouth. The unique sensory/manipulatory capabilities of the cephalic lobes, as well as the cownose ray's hydraulic excavation/winnowing behaviors and suction feeding, make this species an effective benthic predator, despite its epibenthic lifestyle.

Vesicular komatiites, 3.5-Ga Komati Formation, Barberton Greenstone Belt, South Africa: inflation of submarine lavas and origin of spinifex zones

NASA Astrophysics Data System (ADS)

Dann, Jesse

2001-08-01

Komatiites of the 3.5-Ga Komati Formation are ultramafic lavas (>23% MgO) erupted in a submarine, lava plain environment. Newly discovered vesicular komatiites have vesicular upper crusts disrupted by synvolcanic structures that are similar to inflation-related structures of modern lava flows. Detailed outcrop maps reveal flows with upper vesicular zones, 2-15 m thick, which were (1) rotated by differential inflation, (2) intruded by dikes from the interior of the flow, (3) extended, forming a flooded graben, and/or (4) entirely engulfed. The largest inflated structure is a tumulus with 20 m of surface relief, which was covered by a compound flow unit of spinifex flow lobes. The lava that inflated and rotated the upper vesicular crust did not vesiculate, but crystallized as a thick spinifex zone with fist-size skeletal olivine. Instead of representing rapidly cooled lava, the spinifex zone cooled slowly beneath an insulating upper crust during inflation. Overpressure of the inflating lava may have inhibited vesiculation. This work describes the oldest vesicular komatiites known, illustrates the first field evidence for inflated structures in komatiite flows, proposes a new factor in the development of spinifex zones, and concludes that the inflation model is useful for understanding the evolution of komatiite submarine flow fields.

Substorm-associated large-scale magnetic field changes in the magnetotail: a prerequisite for magnetotail deflation events

NASA Astrophysics Data System (ADS)

Nakai, H.; Kamide, Y.

2003-04-01

An attempt is made to search for a critical condition in the lobe magnetic field to initiate large-scale magnetic field changes associated with substorm expansions. Using data from ISEE-1 for 1978, sudden decreases in the lobe magnetic field accompanied by magnetic field dipolarizations are identified. In this study, such events are designated as the magnetotail deflation. The magnetic field component parallel to the equatorial plane, BE , is normalized to a fixed geocentric distance, BEN , and is corrected for the compression effect of the solar wind dynamic pres-sure, BENC . It is shown that the BENC value just prior to a magnetotail deflation correlates well with the Dst index; BENC = 37.5 - 0.217 Dst0, where Dst0 denotes the Dst value corrected for the solar wind dynamic pressure. This regression function appears to delineate the upper limit of BENC values, when they are sorted by the Dst0 index. On the basis of this finding it is suggested that a prerequisite condition for magnetotail deflations must exist in the magnetosphere.

The first VLBI detection of a spiral DRAGN core

NASA Astrophysics Data System (ADS)

Mao, Minnie Y.; Blanchard, Jay M.; Owen, Frazer; Sjouwerman, Loránt O.; Singh, Vikram; Scaife, Anna; Paragi, Zsolt; Norris, Ray P.; Momjian, Emmanuel; Johnson, Gia; Browne, Ian

2018-07-01

We present the first observation of 0313-192, the archetypal spiral DRAGN, at very long baseline interferometry (VLBI) resolutions. Spiral DRAGNs are Double-lobed Radio sources Associated with Galactic Nuclei (DRAGNs) that are hosted by spiral galaxies. 0313-192 is an edge-on spiral galaxy that appears to host a 360 kpc double-lobed radio source. The core of this galaxy is clearly detected at L, S, and X bands using the Very Long Baseline Array, signifying an ongoing active nucleus in the galaxy. This rules out the possibility that the spiral DRAGN is merely a chance alignment. The radio core has L1.4 GHz ˜ 3.0 × 1023 W Hz-1. Radio components are detected to the south-west of the core, but there are no detections of a counterjet. Assuming a symmetric, relativistic jet, we estimate an upper limit to the inclination angle of θ ≲ 72 deg. The VLBI-detected radio jet components are extremely well aligned with the larger scale radio source suggesting little to no jet disruption or interaction with the interstellar medium of the host galaxy.

Combined pulmonary fibrosis and emphysema: The many aspects of a cohabitation contract.

PubMed

Papaioannou, Andriana I; Kostikas, Konstantinos; Manali, Effrosyni D; Papadaki, Georgia; Roussou, Aneza; Kolilekas, Likurgos; Borie, Raphaël; Bouros, Demosthenis; Papiris, Spyridon A

2016-08-01

Combined pulmonary fibrosis and emphysema (CPFE) is a clinical entity characterized by the coexistence of upper lobe emphysema and lower lobe fibrosis. Patients with this condition experience severe dyspnea and impaired gas exchange with preserved lung volumes. The diagnosis of the CPFE syndrome is based on HRCT imaging, showing the coexistence of emphysema and pulmonary fibrosis both in varying extent and locations within the lung parenchyma. Individual genetic background seem to predispose to the development of the disease. The risk of the development of pulmonary hypertension in patients with CPFE is high and related to poor prognosis. CPFE patients also present a high risk of lung cancer. Mortality is significant in patients with CPFE and median survival is reported between 2.1 and 8.5 years. Currently, no specific recommendations are available regarding the management of patients with CPFE. In this review we provide information on the existing knowledge on CPFE regarding the pathophysiology, clinical manifestations, imaging, complications, possible therapeutic interventions and prognosis of the disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

Abnormal parietal encephalomalacia associated with schizophrenia: A case report.

PubMed

Pan, Fen; Wang, Jun-Yuan; Xu, Yi; Huang, Man-Li

2017-03-01

It is widely believed that structural abnormalities of the brain contribute to the pathophysiology of schizophrenia. The parietal lobe is a central hub of multisensory integration, and abnormities in this region might account for the clinical features of schizophrenia. However, few cases of parietal encephalomalacia associated with schizophrenia have been described. In this paper, we present a case of a 25-year-old schizophrenia patient with abnormal parietal encephalomalacia. The patient had poor nutrition and frequently had upper respiratory infections during childhood and adolescence. She showed severe schizophrenic symptoms such as visual hallucinations for 2 years. After examining all her possible medical conditions, we found that the patient had a lesion consistent with the diagnosis of encephalomalacia in her right parietal lobe and slight brain atrophy. The patient was prescribed olanzapine (10 mg per day). Her symptoms significantly improved after antipsychotic treatment and were still well controlled 1 year later. This case suggested that parietal encephalomalacia, which might be caused by inflammatory and infectious conditions in early life and be aggravated by undernutrition, might be implicated in the etiology of schizophrenia.

Confident Surgical Decision Making in Temporal Lobe Epilepsy by Heterogeneous Classifier Ensembles

PubMed Central

Fakhraei, Shobeir; Soltanian-Zadeh, Hamid; Jafari-Khouzani, Kourosh; Elisevich, Kost; Fotouhi, Farshad

2015-01-01

In medical domains with low tolerance for invalid predictions, classification confidence is highly important and traditional performance measures such as overall accuracy cannot provide adequate insight into classifications reliability. In this paper, a confident-prediction rate (CPR) which measures the upper limit of confident predictions has been proposed based on receiver operating characteristic (ROC) curves. It has been shown that heterogeneous ensemble of classifiers improves this measure. This ensemble approach has been applied to lateralization of focal epileptogenicity in temporal lobe epilepsy (TLE) and prediction of surgical outcomes. A goal of this study is to reduce extraoperative electrocorticography (eECoG) requirement which is the practice of using electrodes placed directly on the exposed surface of the brain. We have shown that such goal is achievable with application of data mining techniques. Furthermore, all TLE surgical operations do not result in complete relief from seizures and it is not always possible for human experts to identify such unsuccessful cases prior to surgery. This study demonstrates the capability of data mining techniques in prediction of undesirable outcome for a portion of such cases. PMID:26609547

Surprising Rapid Collapse of Sirius B from Red Giant to White Dwarf Through Mass Transfer to Sirius a

NASA Astrophysics Data System (ADS)

Yousef, Shahinaz; Ali, Ola

2013-03-01

Sirius was observed in antiquity as a red star. In his famous astronomy textbook the Almagest written 140 AD, Ptolemy described the star Sirius as fiery red. He curiously depicted it as one of six red-colored stars. The other five are class M and K stars, such as Arcturus and Betelgeuse. Apparent confirmation in ancient Greek and Roman sources are found and Sirius was also reported red in Europe about 1400 years ago. Sirius must have changed to a white dwarf in the night of Ascension. The star chapter in the Quran started with "by the star as it collapsed (1) your companion have not gone astray nor being misled (2), and in verse 49 which is the rotation period of the companion Sirius B around Sirius A, it is said" He is the Lord of Sirius (49). If Sirius actually was red what could have caused it to change into the brilliant bluish-white star we see today? What the naked eye perceives as a single star is actually a binary star system, consisting of a white main sequence star of spectral type A1V, termed Sirius A, and a faint white dwarf companion of spectral type DA2, termed Sirius B. The red color indicates that the star seen then was a red giant. It looks that what they have seen in antiquity was Sirius B which was then a red giant and it collapsed to form a white dwarf. Since there is no evidence of a planetary nebula, then the red Sirius paradox can be solved in terms of stellar evolution with mass transfer. Sirius B was the most massive star which evolved to a red giant and filled the Roche lobe. Mass transfer to Sirius A occurred through the Lagrangian point. Sirius A then became more massive while Sirius B lost mass and shrank. Sirius B then collapsed abruptly into a white dwarf. In the case of Algol, Ptolmy observed it as white star but it was red at the time of El sufi. At present it is white. The rate of mass transfer from Sirius B to Sirius A, and from Algol B to A is estimated from observational data of colour change from red to bullish white to be 0.0021 and 0.0024 M⊙/yr respectively.

Signs of Asymmetry in Exploding Stars

NASA Astrophysics Data System (ADS)

Hensley, Kerry

2018-03-01

Supernova explosions enrich the interstellar medium and can even briefly outshine their host galaxies. However, the mechanism behind these massive explosions still isnt fully understood. Could probing the asymmetry of supernova remnants help us better understand what drives these explosions?Hubble image of the remnant of supernova 1987A, one of the first remnants discovered to be asymmetrical. [ESA/Hubble, NASA]Stellar Send-OffsHigh-mass stars end their lives spectacularly. Each supernova explosion churns the interstellar medium and unleashes high-energy radiation and swarms of neutrinos. Supernovae also suffuse the surrounding interstellar medium with heavy elements that are incorporated into later generations of stars and the planets that form around them.The bubbles of expanding gas these explosions leave behind often appear roughly spherical, but mounting evidence suggests that many supernova remnants are asymmetrical. While asymmetry in supernova remnants can arise when the expanding material plows into the non-uniform interstellar medium, it can also be an intrinsic feature of the explosion itself.Simulation results clockwise from top left: Mass density, calcium mass fraction, oxygen mass fraction, nickel-56 mass fraction. Click to enlarge. [Adapted from Wollaeger et al. 2017]Coding ExplosionsThe presence or absence of asymmetry in a supernova remnant can hold clues as to what drove the explosion. But how can we best observe asymmetry in a supernova remnant? Modeling lets us explore different observational approaches.A team of scientists led by Ryan T. Wollaeger (Los Alamos National Laboratory) used radiative transfer and radiative hydrodynamics simulations to model the explosion of a core-collapse supernova. Wollaeger and collaborators introduced asymmetry into the explosion by creating a single-lobed, fast-moving outflow along one axis.Their simulations showed that while some chemical elements lingered near the origin of the explosion or were distributed evenly throughout the remnant, calcium was isolated to the asymmetrical region, hinting that spectral lines of calcium may be good tracersof asymmetry.Bolometric (top) and gamma-ray (bottom) synthetic light curves for the authors model for a range of simulated viewing angles. [Adapted from Wollaeger et al. 2017]Synthesizing SpectraWollaeger and collaborators then generated synthetic light curves and spectra from their models to determine which spectral features or characteristics indicated the presence of the asymmetric outflow lobe. They found that when an asymmetric outflow lobe is present, the peak luminosity of the explosion depends on the angle at which you view it; the highest luminosity occurs when the lobe is viewed from the side, while the lowest luminosity nearly40%dimmer is seen when the explosion is viewed down the barrel of the lobe. The dense outflow shades the central radioactive source from view, lowering the luminosity.This effect also plays out in the gamma-ray light curves; when viewed down the barrel, the shading of the central source by ahigh-density lobe slows the rise of the gamma-ray luminosity and changes the shape of the light curve compared to views from other vantage points.Another promising avenue for exploring asymmetry is a near-infrared band encompassing an emission line of singly-ionized calcium near 815 nm. Since calcium is confined within the outflow lobe in the simulation, its emission lines are blueshifted when the lobe points toward the observer.The authors point out that there is much more to be done in their models, such as including the effects of shock heating of circumstellar material, which can contribute strongly to the light curve, but these simulations bring us a step closer to understanding the nature of asymmetrical supernova remnants and the explosions that create them.CitationRyan T. Wollaeger et al 2017ApJ845168. doi:10.3847/1538-4357/aa82bd

Drug-induced sleep endoscopy with target-controlled infusion using propofol and monitored depth of sedation to determine treatment strategies in obstructive sleep apnea.

PubMed

Heiser, Clemens; Fthenakis, Phillippe; Hapfelmeier, Alexander; Berger, Sebastian; Hofauer, Benedikt; Hohenhorst, Winfried; Kochs, Eberhard F; Wagner, Klaus J; Edenharter, Guenther M

2017-09-01

Drug-induced sleep endoscopy (DISE) has become an important diagnostic examination tool in the treatment decision process for surgical therapies in the treatment of obstructive sleep apnea (OSA). Currently, there is a variety of regimes for the performance of DISE, which renders comparison and assessment across results difficult. It remains unclear how the different regimes influence the findings of the examination and the resulting conclusions and treatment recommendations. This study aimed to investigate the correlation between increasing levels of sedation (i.e., light, medium, and deep) induced by propofol using a target-controlled infusion (TCI) pump, with the obstruction patterns at the levels of the velum, oropharynx, tongue base, and epiglottis (i.e., VOTE classification). A second goal was the establishment of a sufficient sedation level to enable a reliable decision regarding treatment recommendations. Forty-three patients with OSA underwent a DISE procedure using propofol TCI. Three levels of sedation were defined, depending on entropy levels and assessment of sedation: light sedation, medium sedation, and deep sedation. The evaluation of the upper airway at each level, with increasing sedation, was documented using the VOTE classification. The elapsed time at which each assessment was performed was recorded. Upper airway changes occurred and were measured throughout the DISE procedure. Clinically useful determinations of airway closure occurred at medium sedation; this level of sedation was most probably achieved with a blood propofol concentration of 3.2 μg/ml. In all 43 patients, definite treatment decisions could be made at medium sedation level. Increasing sedation did not result in changes in the treatment decision. Changes in upper airway collapse during DISE with propofol TCI occur at levels of medium sedation. Decisions regarding surgical treatment could be made at this level of sedation. Upper Airway Collapse in Patients with Obstructive Sleep Apnea Syndrome by Drug Induced Sleep Endoscopy (URL: https://clinicaltrials.gov/ct2/results?term=NCT02588300&Search=Search ) REGISTRATION NUMBER: NCT02588300.

Periorbital and Mediastinal Emphysema after Upper Gastrointestinal Endoscopy: Case Report of a Rare Complication.

PubMed

Lekha, Thankappan; Venkatakrishnan, Leelakrishnan; Divya, Karuppannasamy; Lavanya, Perumal

2017-01-01

To report a rare case of periorbital emphysema concurrent with cervicofacial and mediastinal emphysema in an elderly woman who underwent upper gastrointestinal endoscopy for chronic liver disease. An elderly woman with decompensated chronic liver disease presented with features of periorbital, facial, and mediastinal emphysema, characterized with crepitant swelling over the right periorbital area, face, neck, and mediastinum after undergoing upper gastrointestinal endoscopy. There was no history of trauma or Valsalva maneuver. Ocular findings were stable with no evidence of orbital compartmental syndrome. Urgent computed tomography scans of the orbit and chest were performed, and emergency systemic treatment with nasogastric decompression and antibiotics was initiated. However, she suddenly collapsed and succumbed despite all resuscitative efforts. Our case demonstrates that periorbital emphysema can occur following procedures such as upper gastrointestinal endoscopy, in the eyes without history of local trauma. This complication should be suspected especially if there is associated cervicofacial and mediastinal emphysema. Subcutaneous emphysema is usually self-resolving; however, extension of air into deeper planes can cause dangerous complications such as blindness due to orbital emphysema or mortality due to mediastinal emphysema. Hence, prompt diagnosis and urgent intervention are crucial to avoid vision and life threatening complications.

Depositional architecture and evolution of the Late Miocene slope channel-fan-system in the northeastern shelf-margin of South China Sea

NASA Astrophysics Data System (ADS)

Jiang, Jing; Lin, Changsong; Zhang, Zhongtao; Tian, Hongxun; Tao, Ze; Liu, Hanyao

2016-04-01

The Upper Miocene in the Pearl River Mouth Basin of northwestern shelf-margin of South China Sea Basin contains a series of slope channel - fan systems. Their depositional architecture and evolution are documented in this investigation based on an integrated analysis of cores, logs, and seismic data. Four depositional-palaeogeomorphological elements have been identified in the slope channel-fan systems as follows: broad, shallow and unconfined or partly confined outer-shelf to shelf-break channels; deeply incised and confined unidirectionally migrating slope channels; broad or U-shaped, unconfined erosional-depositional channels; frontal splays-lobes and nonchannelized sheets. The slope channels are mostly oriented NW-SE, which migrated unidirectionally northeastwards and intensively eroded almost the whole shelf-slope zone. The channel infillings are mainly mudstones, interbedded with siltstones. They might be formed by gravity flow erosion as bypassing channels. They were filled with limited gravity flow sediments at the base and mostly filled with lateral accretionary packages of bottom current deposits. At the end of the channels, a series of small-scale slope fans developed and coalesced into fan aprons along the base of the slope. The unconfined erosional-depositional channels at the upper parts of the fan-apron-systems display compound infill patterns, and commonly have concave erosional bases and convex tops. The frontal splays-lobes representing middle to distal deposits of fan-apron-systems have flat-mounded or gull-wing geometries, and the internal architectures include bidirectional downlap, progradation, and chaotic infillings. The distal nonchannelized turbidite sheets are characterized by thin-bedded, parallel to sub-parallel sheet-like geometries. Three major unconformities or obvious erosional surfaces in the channel-fan systems of the Upper Miocene are recognized, and indicate the falling of sea-level. The depositional architecture of sequences varies from the upper slope to the slope base transitional to basin plain. The basal erosion and the unidirectionally migrating characters of the slope channels were supposed to be the result of the interaction of bottom currents and gravity flows. The intensive development of the channel-fan systems over the shelf slope might be related to the Dongsha Tectonic uplift which may resulted in stepped slope and concomitantly intensified gravity flow in the study area in Late Miocene.

Aspergillus epidural abscess in a patient with obstructive airway disease.

PubMed Central

Chee, Y. C.; Poh, S. C.

1983-01-01

A 54-year-old Chinese man with episodic bronchial asthma since 25 years of age was treated for pulmonary tuberculosis in 1976 because of left upper lobe lesions on chest radiograph. In 1981 he presented with an extradural mass compressing the thoracic spinal cord, thought to be tuberculosis but which on biopsy was found to be aspergillosis. Sputum culture, type on skin-prick reactivity and serum precipitating antibodies were positive for Aspergillus. Amphotericin B intravenously, then ketoconazole orally did not substantially improve his clinical course. He died about four months post-laminectomy. PMID:6866873

Tuberculosis post-liver transplantation: a rare but complicated disease.

PubMed

Lu, W; Wai, C T; Da Costa, M; Tambyah, P A; Prabhakaran, K; Lee, K H

2005-03-01

Tuberculosis is a rare but serious complication after transplantation. We report a case and discuss its presentation and management. A 60-year-old Indonesian male presented initially with fever, acute confusion and rapidly progressive right upper lobe pneumonia 3.5 months post-liver transplant, and was diagnosed with pulmonary tuberculosis by positive sputum smear for acid-fast bacilli and tuberculosis culture. Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis. A high level of suspicion, prompt antituberculosis treatment and close follow-up are essential in management of post-transplant tuberculosis.

Successful closure of chronic BPF by thoracoscopy after failure of endoscopic fibrin glue application and thoracoplasty.

PubMed

Tschopp, J M; Evéquoz, D; Karrer, W; Aymon, E; Naef, A P

1990-03-01

We report a case of chronic debilitating BPF following right upper lobe resection. Despite several endobronchial applications of fibrin glue, we could not close it. Since the patient was extremely debilitated by symptoms due to the BPF, a thoracoplasty was attempted but was not successful. Finally, the BPF was definitely closed by instillation of talc into the pleura through thoracoscopy. To our knowledge, this is the first reported case of chemical closure of a recalcitrant BPF by the route of thoracoscopy. It also shows the failure of endoscopic fibrin glue application in such a condition.

Brittle and Ductile Behavior in Deep-Seated Landslides: Learning from the Vajont Experience

NASA Astrophysics Data System (ADS)

Paronuzzi, Paolo; Bolla, Alberto; Rigo, Elia

2016-06-01

This paper analyzes the mechanical behavior of the unstable Mt. Toc slope before the 1963 catastrophic collapse, considering both the measured data (surface displacements and microseismicity) and the updated geological model of the prehistoric rockslide. From February 1960 up to 9 October 1963, the unstable mass behaved as a brittle-ductile `mechanical system,' characterized by remarkable microseismicity as well as by considerable surface displacements (up to 4-5 m). Recorded microshocks were the result of progressive rock fracturing of distinct resisting stiff parts made up of intact rock (indentations, undulations, and rock bridges). The main resisting stiff part was a large rock indentation located at the NE extremity of the unstable mass that acted as a mechanical constraint during the whole 1960-1963 period, inducing a progressive rototranslation toward the NE. This large constraint failed in autumn 1960, when an overall slope failure took place, as emphasized by the occurrence of the large perimetrical crack in the upper slope. In this circumstance, the collapse was inhibited by a reblocking phenomenon of the unstable mass that had been previously destabilized by the first reservoir filling. Progressive failure of localized intact rock parts progressively propagated westwards as a consequence of the two further filling-drawdown cycles of the reservoir (1962 and 1963). The characteristic brittle-ductile behavior of the Vajont landslide was made possible by the presence of a very thick (40-50 m) and highly deformable shear zone underlying the upper rigid rock mass (100-120 m thick).

Sleep-Disordered Breathing in Neuromuscular Disease: Diagnostic and Therapeutic Challenges.

PubMed

Aboussouan, Loutfi S; Mireles-Cabodevila, Eduardo

2017-10-01

Normal sleep-related rapid eye movement sleep atonia, reduced lung volumes, reduced chemosensitivity, and impaired airway dilator activity become significant vulnerabilities in the setting of neuromuscular disease. In that context, the compounding effects of respiratory muscle weakness and disease-specific features that promote upper airway collapse or cause dilated cardiomyopathy contribute to various sleep-disordered breathing events. The reduction in lung volumes with neuromuscular disease is further compromised by sleep and the supine position, exaggerating the tendency for upper airway collapse and desaturation with sleep-disordered breathing events. The most commonly identified events are diaphragmatic/pseudo-central, due to a decrease in the rib cage contribution to the tidal volume during phasic rapid eye movement sleep. Obstructive and central sleep apneas are also common. Noninvasive ventilation can improve survival and quality of sleep but should be used with caution in the context of dilated cardiomyopathy or significant bulbar symptoms. Noninvasive ventilation can also trigger sleep-disordered breathing events, including ineffective triggering, autotriggering, central sleep apnea, and glottic closure, which compromise the potential benefits of the intervention by increasing arousals, reducing adherence, and impairing sleep architecture. Polysomnography plays an important diagnostic and therapeutic role by correctly categorizing sleep-disordered events, identifying sleep-disordered breathing triggered by noninvasive ventilation, and improving noninvasive ventilation settings. Optimal management may require dedicated hypoventilation protocols and a technical staff well versed in the identification and troubleshooting of respiratory events. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Outcrop-scale acoustic facies analysis and latest Quaternary development of Hueneme and Dume submarine fans, offshore California

USGS Publications Warehouse

Piper, D.J.W.; Hiscott, R.N.; Normark, W.R.

1999-01-01

The uppermost Quaternary deposits of the Hueneme and Dume submarine fans in the Santa Monica Basin have been investigated using a closed-spaced grid of boomer seismic-reflection profiles, which give vertical resolution of a few tens of centimetres with acoustic penetration to 50 m. Acoustic facies integrated with geometry define six architectural elements, some with discrete subelements that are of a scale that can be recognized in outcrops of ancient turbidite systems. In the Santa Monica Basin, the relationship of these elements to fan morphology, stratigraphy and sediment source is precisely known. The width of upper Hueneme fan valley has been reduced from 5 km since the last glacial maximum to 1 km at present by construction of laterally confined sandy levees within the main valley. The middle fan comprises three main subelements: thick sand deposits at the termination of the fan valley, low-gradient sandy lobes typically 5 km long and < 10 m thick, and scoured lobes formed of alternating sand and mud beds with many erosional depressions. The site of thickest lobe sediment accumulation shifts through time, with each sand bed deposited in a previous bathymetric low (i.e. compensation cycles). The lower fan and basin plain consists of sheet-like alternations of sand and mud with shallow channels and lenses. Variations in the rate of late Quaternary sea level rise initiated changes in sediment facies distribution. At lowstand, and during the approximately 11 ka stillstand in sea level, the Hueneme Fan was fed largely by hyperpycnal flow from the Santa Clara River delta, depositing high sediment waves on the right hand levee and thick sandy lobes on the middle fan. At highstand of sea level, most turbidity currents were generated by failure of silty prodelta muds. In contrast, the smaller Dume Fan was apparently always fed from littoral drift of sand through a single-canyon point source.

Size-frequency distribution of boulders ≥7 m on comet 67P/Churyumov-Gerasimenko

NASA Astrophysics Data System (ADS)

Pajola, Maurizio; Vincent, Jean-Baptiste; Güttler, Carsten; Lee, Jui-Chi; Bertini, Ivano; Massironi, Matteo; Simioni, Emanuele; Marzari, Francesco; Giacomini, Lorenza; Lucchetti, Alice; Barbieri, Cesare; Cremonese, Gabriele; Naletto, Giampiero; Pommerol, Antoine; El-Maarry, Mohamed R.; Besse, Sébastien; Küppers, Michael; La Forgia, Fiorangela; Lazzarin, Monica; Thomas, Nicholas; Auger, Anne-Thérèse; Sierks, Holger; Lamy, Philippe; Rodrigo, Rafael; Koschny, Detlef; Rickman, Hans; Keller, Horst U.; Agarwal, Jessica; A'Hearn, Michael F.; Barucci, Maria A.; Bertaux, Jean-Loup; Da Deppo, Vania; Davidsson, Björn; De Cecco, Mariolino; Debei, Stefano; Ferri, Francesca; Fornasier, Sonia; Fulle, Marco; Groussin, Olivier; Gutierrez, Pedro J.; Hviid, Stubbe F.; Ip, Wing-Huen; Jorda, Laurent; Knollenberg, Jörg; Kramm, J.-Rainer; Kürt, Ekkehard; Lara, Luisa M.; Lin, Zhong-Yi; Lopez Moreno, Jose J.; Magrin, Sara; Marchi, Simone; Michalik, Harald; Moissl, Richard; Mottola, Stefano; Oklay, Nilda; Preusker, Frank; Scholten, Frank; Tubiana, Cecilia

2015-11-01

Aims: We derive for the first time the size-frequency distribution of boulders on a comet, 67P/Churyumov-Gerasimenko (67P), computed from the images taken by the Rosetta/OSIRIS imaging system. We highlight the possible physical processes that lead to these boulder size distributions. Methods: We used images acquired by the OSIRIS Narrow Angle Camera, NAC, on 5 and 6 August 2014. The scale of these images (2.44-2.03 m/px) is such that boulders ≥7 m can be identified and manually extracted from the datasets with the software ArcGIS. We derived both global and localized size-frequency distributions. The three-pixel sampling detection, coupled with the favorable shadowing of the surface (observation phase angle ranging from 48° to 53°), enables unequivocally detecting boulders scattered all over the illuminated side of 67P. Results: We identify 3546 boulders larger than 7 m on the imaged surface (36.4 km2), with a global number density of nearly 100/km2 and a cumulative size-frequency distribution represented by a power-law with index of -3.6 +0.2/-0.3. The two lobes of 67P appear to have slightly different distributions, with an index of -3.5 +0.2/-0.3 for the main lobe (body) and -4.0 +0.3/-0.2 for the small lobe (head). The steeper distribution of the small lobe might be due to a more pervasive fracturing. The difference of the distribution for the connecting region (neck) is much more significant, with an index value of -2.2 +0.2/-0.2. We propose that the boulder field located in the neck area is the result of blocks falling from the contiguous Hathor cliff. The lower slope of the size-frequency distribution we see today in the neck area might be due to the concurrent processes acting on the smallest boulders, such as i) disintegration or fragmentation and vanishing through sublimation; ii) uplifting by gas drag and consequent redistribution; and iii) burial beneath a debris blanket. We also derived the cumulative size-frequency distribution per km2 of localized areas on 67P. By comparing the cumulative size-frequency distributions of similar geomorphological settings, we derived similar power-law index values. This suggests that despite the selected locations on different and often opposite sides of the comet, similar sublimation or activity processes, pit formation or collapses, as well as thermal stresses or fracturing events occurred on multiple areas of the comet, shaping its surface into the appearance we see today.

Prolonged remission of advanced bronchoalveolar adenocarcinoma in a dog treated with autologous, tumour-derived chaperone-rich cell lysate (CRCL) vaccine.

PubMed

Epple, Laura M; Bemis, Lynne T; Cavanaugh, Ryan P; Skope, Anne; Mayer-Sonnenfeld, Tehila; Frank, Chad; Olver, Christine S; Lencioni, Alex M; Dusto, Nathaniel L; Tal, Alona; Har-Noy, Michael; Lillehei, Kevin O; Katsanis, Emmanuel; Graner, Michael W

2013-08-01

This paper presents the treatment of a 12-year-old female spayed Great Dane who presented with vestibular signs (ataxia, nystagmus, hind end collapse). Thoracic radiographs revealed a discrete pulmonary nodule in the right cranial lung lobe. Ultrasound-guided fine needle aspirate detected primary bronchoalveolar adenocarcinoma, verified via computed tomography, with a second smaller nodule discovered in the right cranial lung lobe. A lateral thoracotomy with right cranial lung lobectomy was performed. Histopathological analysis of the nodules and an excised lymph node identified grade III bronchoalveolar adenocarcinoma with vascular infiltration and lymph node metastasis - a grim diagnosis with a reported median survival time of 6-27 days. A 10-g sample of the tumour was processed into a chaperone-rich cell lysate (CRCL) vaccine, which was administered weekly to the patient. Imiquimod - a Toll-like receptor 7 (TLR7) agonist - was applied topically for the first 12 treatments to stimulate local Langerhans cells. A single injection of bacillus Calmette-Guerin (BCG) was administered for additional immune stimulation at week 30 of treatment. The dog remained stable and in otherwise good health until diffuse relapse occurred 44 weeks after the initial treatment; following gastrointestinal bleeding, the dog was euthanised 50+ weeks post diagnosis. To the authors' knowledge, this is the first report of significantly prolonged survival following a diagnosis of grade III/stage III bronchoalveolar adenocarcinoma in a canine patient. This case report suggests that CRCL vaccine combined with topical imiquimod is a safe, effective treatment for canine tumours.

Qualitative assessment of awake nasopharyngoscopy for prediction of oral appliance treatment response in obstructive sleep apnoea.

PubMed

Sutherland, Kate; Chan, Andrew S L; Ngiam, Joachim; Darendeliler, M Ali; Cistulli, Peter A

2018-01-23

Clinical methods to identify responders to oral appliance (OA) therapy for obstructive sleep apnoea (OSA) are needed. Awake nasopharyngoscopy during mandibular advancement, with image capture and subsequent processing and analysis, may predict treatment response. A qualitative assessment of awake nasopharyngoscopy would be simpler for clinical practice. We aimed to determine if a qualitative classification system of nasopharyngoscopic observations reflects treatment response. OSA patients were recruited for treatment with a customised two-piece OA. A custom scoring sheet was used to record observations of the pharyngeal airway (velopharynx, oropharynx, hypopharynx) during supine nasopharyngoscopy in response to mandibular advancement and performance of the Müller manoeuvre. Qualitative scores for degree (< 25%, 25-50%, 50-75%, > 75%), collapse pattern (concentric, anteroposterior, lateral) and diameter change (uniform, anteroposterior, lateral) were recorded. Treatment outcome was confirmed by polysomnography after a titration period of 14.6 ± 9.8 weeks. Treatment response was defined as (1) Treatment AHI < 5, (2) Treatment AHI < 10 plus > 50% AHI reduction and (3) > 50% AHI reduction. Eighty OSA patients (53.8% male) underwent nasopharyngoscopy. The most common naspharyngoscopic observation with mandibular advancement was a small (< 50%) increase in velopharyngeal lateral diameter (37.5%). The majority of subjects (72.5%) were recorded as having > 75% velopharyngeal collapse on performance of the Müller manoeuvre. Mandibular advancement reduced the observed level of pharyngeal collapse at all three pharyngeal regions (p < 0.001). None of the nasopharyngoscopic qualitative scores differed between responder and non-responder groups. Qualitative assessment of awake nasopharyngoscopy appears useful for assessing the effect of mandibular advancement on upper airway collapsibility. However, it is not sensitive enough to predict oral appliance treatment outcome.

Gravity, turbulence and the scaling ``laws'' in molecular clouds

NASA Astrophysics Data System (ADS)

Ballesteros-Paredes, Javier

The so-called Larson (1981) scaling laws found empirically in molecular clouds have been generally interpreted as evidence that the clouds are turbulent and fractal. In the present contribution we discussed how recent observations and models of cloud formation suggest that: (a) these relations are the result of strong observational biases due to the cloud definition itself: since the filling factor of the dense structures is small, by thresholding the column density the computed mean density between clouds is nearly constant, and nearly the same as the threshold (Ballesteros-Paredes et al. 2012). (b) When accounting for column density variations, the velocity dispersion-size relation does not appears anymore. Instead, dense cores populate the upper-left corner of the δ v-R diagram (Ballesteros-Paredes et al. 2011a). (c) Instead of a δ v-R relation, a more appropriate relation seems to be δ v 2 / R = 2 GMΣ, which suggest that clouds are in collapse, rather than supported by turbulence (Ballesteros-Paredes et al. 2011a). (d) These results, along with the shapes of the star formation histories (Hartmann, Ballesteros-Paredes & Heitsch 2012), line profiles of collapsing clouds in numerical simulations (Heitsch, Ballesteros-Paredes & Hartmann 2009), core-to-core velocity dispersions (Heitsch, Ballesteros-Paredes & Hartmann 2009), time-evolution of the column density PDFs (Ballesteros-Paredes et al. 2011b), etc., strongly suggest that the actual source of the non-thermal motions is gravitational collapse of the clouds, so that the turbulent, chaotic component of the motions is only a by-product of the collapse, with no significant ``support" role for the clouds. This result calls into question if the scale-free nature of the motions has a turbulent, origin (Ballesteros-Paredes et al. 2011a; Ballesteros-Paredes et al. 2011b, Ballesteros-Paredes et al. 2012).

On the Maximum Mass of Accreting Primordial Supermassive Stars

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woods, T. E.; Heger, Alexander; Whalen, Daniel J.

Supermassive primordial stars are suspected to be the progenitors of the most massive quasars at z ∼ 6. Previous studies of such stars were either unable to resolve hydrodynamical timescales or considered stars in isolation, not in the extreme accretion flows in which they actually form. Therefore, they could not self-consistently predict their final masses at collapse, or those of the resulting supermassive black hole seeds, but rather invoked comparison to simple polytropic models. Here, we systematically examine the birth, evolution, and collapse of accreting, non-rotating supermassive stars under accretion rates of 0.01–10 M {sub ⊙} yr{sup −1} using themore » stellar evolution code Kepler . Our approach includes post-Newtonian corrections to the stellar structure and an adaptive nuclear network and can transition to following the hydrodynamic evolution of supermassive stars after they encounter the general relativistic instability. We find that this instability triggers the collapse of the star at masses of 150,000–330,000 M {sub ⊙} for accretion rates of 0.1–10 M {sub ⊙} yr{sup −1}, and that the final mass of the star scales roughly logarithmically with the rate. The structure of the star, and thus its stability against collapse, is sensitive to the treatment of convection and the heat content of the outer accreted envelope. Comparison with other codes suggests differences here may lead to small deviations in the evolutionary state of the star as a function of time, that worsen with accretion rate. Since the general relativistic instability leads to the immediate death of these stars, our models place an upper limit on the masses of the first quasars at birth.« less

Constraints for the Progenitor Masses of Historic Core-collapse Supernovae

NASA Astrophysics Data System (ADS)

Williams, Benjamin F.; Hillis, Tristan J.; Murphy, Jeremiah W.; Gilbert, Karoline; Dalcanton, Julianne J.; Dolphin, Andrew E.

2018-06-01

We age-date the stellar populations associated with 12 historic nearby core-collapse supernovae (CCSNe) and two supernova impostors; from these ages, we infer their initial masses and associated uncertainties. To do this, we have obtained new Hubble Space Telescope imaging covering these CCSNe. Using these images, we measure resolved stellar photometry for the stars surrounding the locations of the SNe. We then fit the color–magnitude distributions of this photometry with stellar evolution models to determine the ages of any young existing populations present. From these age distributions, we infer the most likely progenitor masses for all of the SNe in our sample. We find ages between 4 and 50 Myr, corresponding to masses from 7.5 to 59 solar masses. There were no SNe that lacked a local young population. Our sample contains four SNe Ib/c; their masses have a wide range of values, suggesting that the progenitors of stripped-envelope SNe are binary systems. Both impostors have masses constrained to be ≲7.5 solar masses. In cases with precursor imaging measurements, we find that age-dating and precursor imaging give consistent progenitor masses. This consistency implies that, although the uncertainties for each technique are significantly different, the results of both are reliable to the measured uncertainties. We combine these new measurements with those from our previous work and find that the distribution of 25 core-collapse SNe progenitor masses is consistent with a standard Salpeter power-law mass function, no upper mass cutoff, and an assumed minimum mass for core-collapse of 7.5 M⊙. The distribution is consistent with a minimum mass <9.5 M⊙.

Comparison of clast frequency and size in the resurge deposits at the Chesapeake Bay impact structure (Eyreville A and Langley cores): Clues to the resurge process

USGS Publications Warehouse

Ormo, J.; Sturkell, E.; Horton, J. Wright; Powars, D.S.; Edwards, L.E.

2009-01-01

Collapse and inward slumping of unconsolidated sedimentary strata expanded the Chesapeake Bay impact structure far beyond its central basement crater. During crater collapse, sediment-loaded water surged back to fill the crater. Here, we analyze clast frequency and granulometry of these resurge deposits in one core hole from the outermost part of the collapsed zone (i.e., Langley) as well as a core hole from the moat of the basement crater (i.e., Eyreville A). Comparisons of clast provenance and flow dynamics show that at both locations, there is a clear change in clast frequency and size between a lower unit, which we interpret to be dominated by slumped material, and an upper, water-transported unit, i.e., resurge deposit. The contribution of material to the resurge deposit was primarily controlled by stripping and erosion. This includes entrainment of fallback ejecta and sediments eroded from the surrounding seafloor, found to be dominant at Langley, and slumped material that covered the annular trough and basement crater, found to be dominant at Eyreville. Eyreville shows a higher content of crystalline clasts than Langley. There is equivocal evidence for an anti-resurge from a collapsing central water plume or, alternatively, a second resurge pulse, as well as a transition into oscillating resurge. The resurge material shows more of a debris-flow-like transport compared to resurge deposits at some other marine target craters, where the ratio of sediment to water has been relatively low. This result is likely a consequence of the combination of easily disaggregated host sediments and a relatively shallow target water depth. ?? 2009 The Geological Society of America.

Sex, stress and sleep apnoea: Decreased susceptibility to upper airway muscle dysfunction following intermittent hypoxia in females.

PubMed

O'Halloran, Ken D; Lewis, Philip; McDonald, Fiona

2017-11-01

Obstructive sleep apnoea syndrome (OSAS) is a devastating respiratory control disorder more common in men than women. The reasons for the sex difference in prevalence are multifactorial, but are partly attributable to protective effects of oestrogen. Indeed, OSAS prevalence increases in post-menopausal women. OSAS is characterized by repeated occlusions of the pharyngeal airway during sleep. Dysfunction of the upper airway muscles controlling airway calibre and collapsibility is implicated in the pathophysiology of OSAS, and sex differences in the neuro-mechanical control of upper airway patency are described. It is widely recognized that chronic intermittent hypoxia (CIH), a cardinal feature of OSAS due to recurrent apnoea, drives many of the morbid consequences characteristic of the disorder. In rodents, exposure to CIH-related redox stress causes upper airway muscle weakness and fatigue, associated with mitochondrial dysfunction. Of interest, in adults, there is female resilience to CIH-induced muscle dysfunction. Conversely, exposure to CIH in early life, results in upper airway muscle weakness equivalent between the two sexes at 3 and 6 weeks of age. Ovariectomy exacerbates the deleterious effects of exposure to CIH in adult female upper airway muscle, an effect partially restored by oestrogen replacement therapy. Intriguingly, female advantage intrinsic to upper airway muscle exists with evidence of substantially greater loss of performance in male muscle during acute exposure to severe hypoxic stress. Sex differences in upper airway muscle physiology may have relevance to human OSAS. The oestrogen-oestrogen receptor α axis represents a potential therapeutic target in OSAS, particularly in post-menopausal women. Copyright © 2016 Elsevier B.V. All rights reserved.

Paleoenvironmental reconstruction of lagoonal strata from Sri Lanka using multiple physical properties proxies to assure stratigraphic continuity

NASA Astrophysics Data System (ADS)

Ranasinghage, P. N.; Ortiz, J. D.; Moore, A.; Siriwardana, C.

2009-12-01

Core collapsing is a common problem in studies of lagoonal sediment cores. Coring liquefied sediments below the water table can lead to collapse of material from upper core drives in to the hole. This can be prevented by casing the hole. But casing is not always possible due to practical issues such as coring device type, resources, or time constraints. In such cases identifying the collapsed material in each drive is necessary to ensure accurate results. Direct visual identification of collapsed portion is not always possible and may not be precise. This study successfully recognized collapsed material using a suite of physical properties measurements including: visible (VIS) reflectance spectroscopy, magnetic susceptibility and grain size spectra. This enables us to use the verified stratigraphically continuous records for paleo-environmental studies. Sediment cores were collected from three coastal lagoons and a swale along south eastern and eastern Sri Lanka. Cores were collected using a customized AMS soil coring device with a 1-m long sample barrel. The metal barrel of this instrument collects a 2.5 cm diameter sample in 1-m long plastic tubes. Coring was conducted to refusal, with a maximum depth of 5 m. Casing was not applied to the holes due to small core diameter and time constrains. Drill holes were placed at locations situated both below and above the water level of the lagoons. A total of 100 m of sediment core were obtained from these locations. After opening the cores, suspected collapsed material was initially identified by visual observation using a high power binocular microscope. Particle size, magnetic susceptibility, X-ray fluorescence (XRF) and Diffuse Spectral Reflectance (DSR) was then measured on all cores at 1-2 cm resolution to precisely define the repeated sediment intervals. Down core variation plots of magnetic susceptibility, CIE L* (lightness), a*(red/green difference), b* (blue and yellow difference) clearly record abrupt changes at core drive boundaries at the presence of collapsed material. The correlation of grain-size spectra from the bottom and top of consecutive drives was used to precisely determine the thickness of the collapsed material between drives. Our analysis of 48 m of core material thus far indicates that ~4.4m or ~9% of the record represents collapsed material which can be excluded from further study. The remaining continuous record was analyzed for paleoenvironmental studies. Down core variation of grain size, geochemical ratios, principle components of DSR and geochemical data, and magnetic susceptibility from all locations indicate a gradual filling of these deep lagoons and a transition from reducing to oxic conditions. According to an age model constructed for a nearby lagoon the onset of regression began ~6,000 years BP. Several instantaneous sedimentation events were recorded in all lagoons. Further studies will be carried out to determine whether these represent tsunami, storm surge, or flood deposits.

Simulating video-assisted thoracoscopic lobectomy: a virtual reality cognitive task simulation.

PubMed

Solomon, Brian; Bizekis, Costas; Dellis, Sophia L; Donington, Jessica S; Oliker, Aaron; Balsam, Leora B; Zervos, Michael; Galloway, Aubrey C; Pass, Harvey; Grossi, Eugene A

2011-01-01

Current video-assisted thoracoscopic surgery training models rely on animals or mannequins to teach procedural skills. These approaches lack inherent teaching/testing capability and are limited by cost, anatomic variations, and single use. In response, we hypothesized that video-assisted thoracoscopic surgery right upper lobe resection could be simulated in a virtual reality environment with commercial software. An anatomy explorer (Maya [Autodesk Inc, San Rafael, Calif] models of the chest and hilar structures) and simulation engine were adapted. Design goals included freedom of port placement, incorporation of well-known anatomic variants, teaching and testing modes, haptic feedback for the dissection, ability to perform the anatomic divisions, and a portable platform. Preexisting commercial models did not provide sufficient surgical detail, and extensive modeling modifications were required. Video-assisted thoracoscopic surgery right upper lobe resection simulation is initiated with a random vein and artery variation. The trainee proceeds in a teaching or testing mode. A knowledge database currently includes 13 anatomic identifications and 20 high-yield lung cancer learning points. The "patient" is presented in the left lateral decubitus position. After initial camera port placement, the endoscopic view is displayed and the thoracoscope is manipulated via the haptic device. The thoracoscope port can be relocated; additional ports are placed using an external "operating room" view. Unrestricted endoscopic exploration of the thorax is allowed. An endo-dissector tool allows for hilar dissection, and a virtual stapling device divides structures. The trainee's performance is reported. A virtual reality cognitive task simulation can overcome the deficiencies of existing training models. Performance scoring is being validated as we assess this simulator for cognitive and technical surgical education. Copyright © 2011. Published by Mosby, Inc.

Airflow in Tracheobronchial Tree of Subjects with Tracheal Bronchus Simulated Using CT Image Based Models and CFD Method.

PubMed

Qi, Shouliang; Zhang, Baihua; Yue, Yong; Shen, Jing; Teng, Yueyang; Qian, Wei; Wu, Jianlin

2018-03-01

Tracheal Bronchus (TB) is a rare congenital anomaly characterized by the presence of an abnormal bronchus originating from the trachea or main bronchi and directed toward the upper lobe. The airflow pattern in tracheobronchial trees of TB subjects is critical, but has not been systemically studied. This study proposes to simulate the airflow using CT image based models and the computational fluid dynamics (CFD) method. Six TB subjects and three health controls (HC) are included. After the geometric model of tracheobronchial tree is extracted from CT images, the spatial distribution of velocity, wall pressure, wall shear stress (WSS) is obtained through CFD simulation, and the lobar distribution of air, flow pattern and global pressure drop are investigated. Compared with HC subjects, the main bronchus angle of TB subjects and the variation of volume are large, while the cross-sectional growth rate is small. High airflow velocity, wall pressure, and WSS are observed locally at the tracheal bronchus, but the global patterns of these measures are still similar to those of HC. The ratio of airflow into the tracheal bronchus accounts for 6.6-15.6% of the inhaled airflow, decreasing the ratio to the right upper lobe from 15.7-21.4% (HC) to 4.9-13.6%. The air into tracheal bronchus originates from the right dorsal near-wall region of the trachea. Tracheal bronchus does not change the global pressure drop which is dependent on multiple variables. Though the tracheobronchial trees of TB subjects present individualized features, several commonalities on the structural and airflow characteristics can be revealed. The observed local alternations might provide new insight into the reason of recurrent local infections, cough and acute respiratory distress related to TB.

Concurrent Chemotherapy and Radiation Therapy for Inoperable Locally Advanced Non-Small-Cell Lung Cancer.

PubMed

Rosenzweig, Kenneth E; Gomez, Jorge E

2017-01-01

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 72-year-old man with a 40-pack-year tobacco history developed a cough and decreased exercise tolerance. A chest x-ray demonstrated a right-upper-lobe opacity. Chest computed tomography (CT) scan revealed a 2.5-cm mass in the right upper lobe with multiple mediastinal lymph node disease ( Fig 1 ). A positron emission tomography (PET) scan confirmed the lung lesion and the mediastinal lymphadenopathy without distant metastases. Brain magnetic resonance imaging results were negative. The biopsy specimen revealed adenocarcinoma with no actionable mutations present. Cervical mediastinoscopy was positive for carcinoma in level 2, 3, 4R, and 7 lymph nodes; level 4L was negative. The patient's stage was T1bN2M0, stage IIIA. His medical history was significant for hyperlipidemia and hypothyroidism. He had smoked one pack a day for 40 years and had quit 15 years earlier. Physical examination was unrevealing, and the patient had an Eastern Cooperative Oncology Group performance status of 0. Because of the extent of lung cancer in the mediastinum, the patient's cancer was deemed inoperable, and he was referred for consideration of concurrent chemotherapy and radiation.

Radiological pleuroparenchymal fibroelastosis associated to limited cutaneous systemic sclerosis: a case report.

PubMed

Hassoun, D; Dirou, S; Arrigoni, P P; Durant, C; Hamidou, M; Néel, A; Agard, C

2018-05-18

Pleuroparenchymal fibroelastosis (PPFE) is a very rare interstitial lung disease (ILD) characterized by progressive fibrotic lesions of the visceral pleura and the sub-pleural parenchyma, affecting predominantly the upper lobes. PPFE may occur in different contextes like bone marrow or lung transplantations, but also in the context of telomeropathy with mutations of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) or regulator of telomere elongation helicase 1 (RTEL1) genes. PPFE-like lesions have recently been described in patients with connective tissue disease (CTD)-related ILD. We report here the first detailed case of PPFE associated to systemic sclerosis (SSc) in a woman free of telomeropathy mutations. A caucasian 46 year old woman was followed for SSc in a limited form with anti-centromere Ab since 1998, and seen in 2008 for a routine visit. Her SSc was stable, and she had no respiratory signs. Pulmonary function tests showed an isolated decreased cTLCO at 55.9% (of predicted value). Cardiac ultrasonography was normal. Thoracic CT-scan showed upper lobes predominant mild and focal pleural and subpleural thickenings, suggestive of PPFE, with a slight worsening at 8 years of follow-up. She remained clinically stable. Biology only found a moderate and stable peripheral thrombocytopenia, and sequencing analysis did not find any mutations in TERT and TERC genes. ILD is frequent in SSc but isolated PPFE has never been described so far. In our case, PPFE is not related to telomeropathy, has indolent outcome and seems to have good prognosis. PPFE might be an extremely rare form of SSc-related ILD, although a fortuitous association remains possible.

Comparison of four software packages for CT lung volumetry in healthy individuals.

PubMed

Nemec, Stefan F; Molinari, Francesco; Dufresne, Valerie; Gosset, Natacha; Silva, Mario; Bankier, Alexander A

2015-06-01

To compare CT lung volumetry (CTLV) measurements provided by different software packages, and to provide normative data for lung densitometric measurements in healthy individuals. This retrospective study included 51 chest CTs of 17 volunteers (eight men and nine women; mean age, 30 ± 6 years), who underwent spirometrically monitored CT at total lung capacity (TLC), functional residual capacity (FRC), and mean inspiratory capacity (MIC). Volumetric differences assessed by four commercial software packages were compared with analysis of variance (ANOVA) for repeated measurements and benchmarked against the threshold for acceptable variability between spirometric measurements. Mean lung density (MLD) and parenchymal heterogeneity (MLD-SD) were also compared with ANOVA. Volumetric differences ranged from 12 to 213 ml (0.20 % to 6.45 %). Although 16/18 comparisons (among four software packages at TLC, MIC, and FRC) were statistically significant (P < 0.001 to P = 0.004), only 3/18 comparisons, one at MIC and two at FRC, exceeded the spirometry variability threshold. MLD and MLD-SD significantly increased with decreasing volumes, and were significantly larger in lower compared to upper lobes (P < 0.001). Lung volumetric differences provided by different software packages are small. These differences should not be interpreted based on statistical significance alone, but together with absolute volumetric differences. • Volumetric differences, assessed by different CTLV software, are small but statistically significant. • Volumetric differences are smaller at TLC than at MIC and FRC. • Volumetric differences rarely exceed spirometric repeatability thresholds at MIC and FRC. • Differences between CTLV measurements should be interpreted based on comparison of absolute differences. • MLD increases with decreasing volumes, and is larger in lower compared to upper lobes.

Congenital lobar emphysema: 30-year case series in two university hospitals*

PubMed Central

Cataneo, Daniele Cristina; Rodrigues, Olavo Ribeiro; Hasimoto, Erica Nishida; Schmidt, Aurelino Fernandes; Cataneo, Antonio José Maria

2013-01-01

OBJECTIVE: To review the cases of patients with congenital lobar emphysema (CLE) submitted to surgical treatment at two university hospitals over a 30-year period. METHODS: We reviewed the medical records of children with CLE undergoing surgical treatment between 1979 and 2009 at the Botucatu School of Medicine Hospital das Clínicas or the Mogi das Cruzes University Hospital. We analyzed data regarding symptoms, physical examination, radiographic findings, diagnosis, surgical treatment, and postoperative follow-up. RESULTS: During the period studied, 20 children with CLE underwent surgery. The mean age at the time of surgery was 6.9 months (range, 9 days to 4 years). All of the cases presented with symptoms at birth or during the first months of life. In all cases, chest X-rays were useful in defining the diagnosis. In cases of moderate respiratory distress, chest CT facilitated the diagnosis. One patient with severe respiratory distress was misdiagnosed with hypertensive pneumothorax and underwent chest tube drainage. Only patients with moderate respiratory distress were submitted to bronchoscopy, which revealed no tracheobronchial abnormalities. The surgical approach was lateral muscle-sparing thoracotomy. The left upper and middle lobes were the most often affected, followed by the right upper lobe. Lobectomy was performed in 18 cases, whereas bilobectomy was performed in 2 (together with bronchogenic cyst resection in 1 of those). No postoperative complications were observed. Postoperative follow-up time was at least 24 months (mean, 60 months), and no late complications were observed. CONCLUSIONS: Although CLE is an uncommon, still neglected disease of uncertain etiology, the radiological diagnosis is easily made and surgical treatment is effective. PMID:24068262

Materials and Processes Engineering's Role in the Reconstruction and Failure Analysis of The Space Shuttle Columbia

NASA Technical Reports Server (NTRS)

Russell, Richard

2005-01-01

Conclusions: The hot gases, having flooded the wing interior, quickly heated the upper and lower wing surfaces allowing the aluminum honeycomb facesheets and the wing tiles to debond. The thin-wall aluminum truss tubes would soon collapse and the aerodynamic and structural integrity of the left wing would be effectively destroyed. The forensic evidence is consistent with the observed External Tank foam impact 81 seconds into launch. This is the most probable cause of the damage to the Reinforced Carbon-Carbon. (RCC) leading edge.

Childhood bone tuberculosis from Roman Pécs, Hungary.

PubMed

Hlavenková, L; Teasdale, M D; Gábor, O; Nagy, G; Beňuš, R; Marcsik, A; Pinhasi, R; Hajdu, T

2015-02-01

A child from a Roman necropolis in Pécs, Hungary (4th century CE) was initially diagnosed with severe spinal osteomyelitis. The post-cranial skeleton displayed bone alterations in the lower thoracic and upper lumbar segments, including vertebral body destruction, collapse and sharp kyphosis, and additional multiple rib lesions, suggesting a most likely diagnosis of pulmonary and spinal tuberculosis. This study discusses a number of selected diagnoses in the context of our pathological findings, complementing the macroscopic examination with radiological and biomolecular analyses. Copyright © 2014 Elsevier GmbH. All rights reserved.

Imaging diagnosis-pulmonary-tracheobronchial prolapse in a new Caledonian giant gecko (Rhacodactylus leachianus).

PubMed

Hoey, Seamus; Keller, Dominique; Chamberlin, Tamara; Pinkerton, Marie; Waller, Kenneth; Drees, Randi

2013-01-01

A 3-year-old male New Caledonian giant gecko, or Leach's gecko (Rhacodactylus leachianus) presented with acute lethargy and coelomic distention. Findings from survey radiographs and an upper gastrointestinal tract contrast study were consistent with severe aerophagia, a collapsed left lung, and hyperinflation of the right lung due to suspected bronchial obstruction. The gecko was treated with conservative medical management, but was found dead 5 days after presentation. Necropsy findings showed intussusception of the proximal left lung into the left mainstem bronchus and trachea. © 2013 Veterinary Radiology & Ultrasound.

Mandibular Advancement Appliance for Obstructive Sleep Apnea Treatment.

PubMed

Kostrzewa-Janicka, J; Śliwiński, P; Wojda, M; Rolski, D; Mierzwińska-Nastalska, E

2017-01-01

A combination of abnormal anatomy and physiology of the upper airway can produce its repetitive narrowing during sleep, resulting in obstructive sleep apnea (OSA). Treatment of sleep-breathing disorder ranges from lifestyle modifications, upper airway surgery, continuous positive airway pressure (CPAP) to the use of oral appliances. A proper treatment selection should be preceded by thorough clinical and instrumental examinations. The type and number of specific oral appliances are still growing. The mandibular advancement appliance (MAA) is the most common type of a dental device in use today. The device makes the mandible protrude forward, preventing or minimizing the upper airway collapse during sleep. A significant variability in the patients' response to treatment has been observed, which can be explained by the severity of sleep apnea at baseline and duration of treatment. In some trials, patients with mild OSA show a similar treatment effect after the use of CPAP or MAA. It is worthwhile to give it a try with an oral appliance of MAA type in snoring, mild-to-moderate sleep apnea, and in individuals who are intolerant to CPAP treatment.

A membranous structure separating the adenohypophysis and neurohypophysis: an anatomical study and its clinical application for craniopharyngioma.

PubMed

Lu, Yun-Tao; Qi, Song-Tao; Xu, Jia-Ming; Pan, Jun; Shi, Jin

2015-06-01

OBJECT This study aimed to identify the membranous septation between the adeno- and neurohypophysis. The clinical impact of this septation in the surgical removal of infradiaphragmatic craniopharyngioma (Id-CP) is also clarified. METHODS The sellar regions from 8 fetal and 6 adult cadavers were dissected. After staining first with H & E and then with picro-Sirius red, the membranous structures were observed and measured under normal light and polarization microscopy. The pre- and postsurgical images and intraoperative procedures in 28 cases of childhood Id-CP were reviewed and analyzed. RESULTS There is a significant membranous septation (termed the adenoneurohypophysis septation [ANHS]) lying behind the intermediate lobe to separate the adeno- and neurohypophysis. The average thicknesses are 21.9 ± 16.9 μm and 79.1 ± 43.2 μm in fetal and adult heads, respectively. The median segment of the septation is significantly thicker than the upper and lower segments. The ANHS extends from the suprasellar pars tuberalis to the sellar floor, where it is fused with the pituitary capsule. During Id-CP surgery performed via a transcranial approach, the ANHS can be identified to reserve the neurohypophysis. Moreover, by understanding the anatomy of this membrane, the pituitary stalk was preserved in 3 patients (10.7%). CONCLUSIONS There is a significant membrane separating the anterior and posterior lobes of the pituitary gland, which lies behind the intermediate lobe. Understanding the anatomy of this septation is important for identifying and preserving the neurohypophysis and pituitary stalk during Id-CP surgery.

Ultrafine particle transport and deposition in a large scale 17-generation lung model.

PubMed

Islam, Mohammad S; Saha, Suvash C; Sauret, Emilie; Gemci, Tevfik; Yang, Ian A; Gu, Y T

2017-11-07

To understand how to assess optimally the risks of inhaled particles on respiratory health, it is necessary to comprehend the uptake of ultrafine particulate matter by inhalation during the complex transport process through a non-dichotomously bifurcating network of conduit airways. It is evident that the highly toxic ultrafine particles damage the respiratory epithelium in the terminal bronchioles. The wide range of in silico available and the limited realistic model for the extrathoracic region of the lung have improved understanding of the ultrafine particle transport and deposition (TD) in the upper airways. However, comprehensive ultrafine particle TD data for the real and entire lung model are still unavailable in the literature. Therefore, this study is aimed to provide an understanding of the ultrafine particle TD in the terminal bronchioles for the development of future therapeutics. The Euler-Lagrange (E-L) approach and ANSYS fluent (17.2) solver were used to investigate ultrafine particle TD. The physical conditions of sleeping, resting, and light activity were considered in this modelling study. A comprehensive pressure-drop along five selected path lines in different lobes was calculated. The non-linear behaviour of pressure-drops is observed, which could aid the health risk assessment system for patients with respiratory diseases. Numerical results also showed that ultrafine particle-deposition efficiency (DE) in different lobes is different for various physical activities. Moreover, the numerical results showed hot spots in various locations among the different lobes for different flow rates, which could be helpful for targeted therapeutical aerosol transport to terminal bronchioles and the alveolar region. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Case for Simulation-Based Mastery Learning Education Courses for Practicing Surgeons.

PubMed

Baumann, Lauren M; Barsness, Katherine A

2018-03-12

Pediatric surgeons rely on simulation courses to develop skills for safe minimally invasive repair of complex congenital anomalies. The majority of minimally invasive surgery (MIS) training courses occur during short "exposure courses" at annual conferences. Little data are available to support the benefit of these courses relative to the safe implementation of new skills. The purpose of this article is to determine the impact of an exposure course for advanced neonatal MIS on self-perceived comfort levels with independent performance of advanced MISs. Participants of a 4-hour hands-on course for neonatal MIS were surveyed regarding clinical practices and pre- and post-training perceived "comfort levels" of MIS skills for thoracoscopic esophageal atresia with tracheoesophageal fistula (tTEF) repair, thoracoscopic left upper lobe pulmonary lobectomy (tLobe), and laparoscopic duodenal atresia (lapDA) repair. Descriptive analyses were performed. Seventeen participants completed pre- and postcourse surveys. The majority of participants had no prior experience with tLobe (59%) or lapDA (53%), and 35% had no experience with tTEF repair. Similarly, the majority were "not comfortable" with these procedures. After the short course, the majority of surgeons reported that they were "likely to perform" these operations within 6 months, despite low levels of baseline experience and comfort levels. An exposure training course led to immediate perception of increased skills and confidence. However, these courses typically do not provide basic tenets of expert performance that demands deliberate practice. Future course design should transition to a mastery learning framework wherein regular skill assessments, milestones, and unlimited education time are prioritized before implementation of the new skills.

Dura mater graft-associated Creutzfeldt-Jakob disease with 30-year incubation period.

PubMed

Shijo, Masahiro; Honda, Hiroyuki; Koyama, Sachiko; Ishitsuka, Koji; Maeda, Koichiro; Kuroda, Junya; Tanii, Mitsugu; Kitazono, Takanari; Iwaki, Toru

2017-06-01

Over 60% of all patients with dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) have been diagnosed in Japan. The incubation period has ranged from 1 to 30 years and the age at onset from 15 to 80 years. Here, we report a 77-year-old male Japanese autopsied dCJD case with the longest incubation period so far in Japan. He received a cadaveric dural graft at the right cranial convexity following a craniotomy for meningioma at the age of 46. At 30 years post-dural graft placement, disorientation was observed as an initial symptom of dCJD. He rapidly began to present with inconsistent speech, cognitive impairment and tremor of the left upper extremity. Occasional myoclonic jerks were predominantly observed on the left side. Brain MRI presented hyperintense signals on diffusion-weighted and T2-weighted images, at the right cerebral cortex. The most hyperintense lesion was located at the right parietal lobe, where the dura mater graft had been transplanted. Single-photon emission CT scan showed markedly decreased cerebral blood flow at the right parietal lobe. EEG revealed diffuse and slow activities with periodic sharp-wave complex discharges seen in the right parietal, temporal and occipital lobes. He died of pneumonia 9 months after onset. Brain pathology revealed non-plaque-type dCJD. Laterality of neuropathological changes, including spongiform change, neuronal loss, gliosis or PrP deposits, was not evident. Western blot analysis showed type 1 PrP CJD . Alzheimer-type pathology and PSP-like pathology were also observed. © 2016 Japanese Society of Neuropathology.

Confining hot spots in 3C 196 - Implications for QSO-companion galaxies

NASA Technical Reports Server (NTRS)

Brown, R. L.; Broderick, J. J.; Mitchell, K. J.

1986-01-01

VLBI observations of the extremely compact hot spot in the northern radio lobe of the QSO 3C 196 reveal the angular size of its smallest substructure to be 0.065 arcsec x 0.045 arcsec or about 300 pc at the redshift distance. The morphology of the hot spot and its orientation relative to the more diffuse radio emission suggest that it is formed by an oblique interaction between the nuclear QSO jet and circum-QSO cloud. The inferred density in this cloud, together with its apparent size, imply that the cloud contains a galactic mass, greater than a billion solar masses of gas. The effect of the jet will be to hasten gravitational collapse of the cloud. If many QSOs such as 3C 196 are formed or found in gas-rich environments, the QSO radio phase may commonly stimulate the metamorphosis of circum-QSO gas to QSO-companion galaxies or it may play a significant part in catalyzing star formation in existing companions.

Giant Double Radio Source DA 240: Purveyor of Galaxies

NASA Astrophysics Data System (ADS)

Chen, Ru-Rong; Strom, Richard; Peng, Bo

2018-05-01

Galaxies of stars are building blocks of the baryonic universe. Their composition, structure, and kinematics have been well studied, but details of their origins remain sketchy. The collapse of gas clouds, induced by external forces whereby gravity overcomes internal pressure to form stars, is the likely starting point. Among the perturbing initiators of galaxy formation, radio source beams (jets) are quite effective. Typically, a beam may spawn one galaxy, though instances of several aligned with the radio axis are known. Recently, we found an impressive 14 companions in the lobes of the giant radio galaxy DA 240, which we argue formed as the result of jet instigation. This conclusion is bolstered by the fact that the galaxy groups display Z-shaped symmetry with respect to the radio axis. There is some evidence for star formation among the aligned companions. We also conclude that galaxy alignments at low redshift may derive from line-emitting gas observed in radio components of high-redshift galaxies.

Small cell lung cancer presenting as unilateral rhinorrhoea.

PubMed

Haymes, Adam; Mahalingam, Sridhayan; Choudhury, Natasha

2017-08-03

The metastatic spread of infraclavicular malignancies to the nasal cavity is rare. We describe the case of a 58-year-old man who presented with a 4-month history of right-sided rhinorrhoea, maxillary hypoesthesia, hyposmia and hypogeusia. Clinical examination revealed an irregular mass within the right nasal cavity. Immunohistochemical analyses of biopsies were consistent with small cell carcinoma of indeterminate origin. A positron emission tomography scan demonstrated extensive mediastinal lymphadenopathy with collapse-consolidation of the right lung's middle lobe and no other sites of metastasis. Following discussion at the lung multidisciplinary team meeting, a diagnosis of metastatic small cell lung cancer (SCLC) was made; the patient was staged with N3, M1b disease and palliative chemo-radiotherapy was started. To the best of our knowledge, this report represents the first documented case of a solitary nasal cavity metastasis arising from a SCLC. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Shear-Wave Elastography for the Estimation of Liver Fibrosis in Chronic Liver Disease: Determining Accuracy and Ideal Site for Measurement

PubMed Central

Dhyani, Manish; Vij, Abhinav; Bhan, Atul K.; Halpern, Elkan F.; Méndez-Navarro, Jorge; Corey, Kathleen E.; Chung, Raymond T.

2015-01-01

Purpose To evaluate the accuracy of shear-wave elastography (SWE) for staging liver fibrosis in patients with diffuse liver disease (including patients with hepatitis C virus [HCV]) and to determine the relative accuracy of SWE measurements obtained from different hepatic acquisition sites for staging liver fibrosis. Materials and Methods The institutional review board approved this single-institution prospective study, which was performed between January 2010 and March 2013 in 136 consecutive patients who underwent SWE before their scheduled liver biopsy (age range, 18–76 years; mean age, 49 years; 70 men, 66 women). Informed consent was obtained from all patients. SWE measurements were obtained at four sites in the liver. Biopsy specimens were reviewed in a blinded manner by a pathologist using METAVIR criteria. SWE measurements and biopsy results were compared by using the Spearman correlation and receiver operating characteristic (ROC) curve analysis. Results SWE values obtained at the upper right lobe showed the highest correlation with estimation of fibrosis (r = 0.41, P < .001). Inflammation and steatosis did not show any correlation with SWE values except for values from the left lobe, which showed correlation with steatosis (r = 0.24, P = .004). The area under the ROC curve (AUC) in the differentiation of stage F2 fibrosis or greater, stage F3 fibrosis or greater, and stage F4 fibrosis was 0.77 (95% confidence interval [CI]: 0.68, 0.86), 0.82 (95% CI: 0.75, 0.91), and 0.82 (95% CI: 0.70, 0.95), respectively, for all subjects who underwent liver biopsy. The corresponding AUCs for the subset of patients with HCV were 0.80 (95% CI: 0.67, 0.92), 0.82 (95% CI: 0.70, 0.95), and 0.89 (95% CI: 0.73, 1.00). The adjusted AUCs for differentiating stage F2 or greater fibrosis in patients with chronic liver disease and those with HCV were 0.84 and 0.87, respectively. Conclusion SWE estimates of liver stiffness obtained from the right upper lobe showed the best correlation with liver fibrosis severity and can potentially be used as a noninvasive test to differentiate intermediate degrees of liver fibrosis in patients with liver disease. © RSNA, 2014 Online supplemental material is available for this article. PMID:25393946

Fracture and compaction of andesite in a volcanic edifice.

PubMed

Heap, M J; Farquharson, J I; Baud, P; Lavallée, Y; Reuschlé, T

The failure mode of lava-dilatant or compactant-depends on the physical attributes of the lava, primarily the porosity and pore size, and the conditions under which it deforms. The failure mode for edifice host rock has attendant implications for the structural stability of the edifice and the efficiency of the sidewall outgassing of the volcanic conduit. In this contribution, we present a systematic experimental study on the failure mode of edifice-forming andesitic rocks (porosity from 7 to 25 %) from Volcán de Colima, Mexico. The experiments show that, at shallow depths (<1 km), both low- and high-porosity lavas dilate and fail by shear fracturing. However, deeper in the edifice (>1 km), while low-porosity (<10 %) lava remains dilatant, the failure of high-porosity lava is compactant and driven by cataclastic pore collapse. Although inelastic compaction is typically characterised by the absence of strain localisation, we observe compactive localisation features in our porous andesite lavas manifest as subplanar surfaces of collapsed pores. In terms of volcano stability, faulting in the upper edifice could destabilise the volcano, leading to an increased risk of flank or large-scale dome collapse, while compactant deformation deeper in the edifice may emerge as a viable mechanism driving volcano subsidence, spreading and destabilisation. The failure mode influences the evolution of rock physical properties: permeability measurements demonstrate that a throughgoing tensile fracture increases sample permeability (i.e. equivalent permeability) by about a factor of two, and that inelastic compaction to an axial strain of 4.5 % reduces sample permeability by an order of magnitude. The implication of these data is that sidewall outgassing may therefore be efficient in the shallow edifice, where rock can fracture, but may be impeded deeper in the edifice due to compaction. The explosive potential of a volcano may therefore be subject to increase over time if the progressive compaction and permeability reduction in the lower edifice cannot be offset by the formation of permeable fracture pathways in the upper edifice. The mode of failure of the edifice host rock is therefore likely to be an important factor controlling lateral outgassing and thus eruption style (effusive versus explosive) at stratovolcanoes.

Ulysses Patera

NASA Technical Reports Server (NTRS)

2002-01-01

[figure removed for brevity, see original site] (Released 18 July 2002) It is helpful to look at the context for this THEMIS image, which covers a large area over the summit of Ulysses Patera. Ulysses Patera is one of the many volcanoes that make up the giant Tharsis volcanic province, although Ulysses itself is fairly small in comparison to the other volcanoes in this area. In the context image, there are 3 circular features near the top of the volcano. The large, central feature is called a 'caldera', and is the result of volcanic activity at Ulysses. The other two circular features are impact craters. The THEMIS image primarily spans across the central caldera, but also covers a portion of the northernmost impact crater. We know that the large central caldera must have formed earlier than the two craters, because its circular form has been cut by the smaller crater rims. In the THEMIS image, there are stair-stepping plateaus in the northern portion of the image. These are part of the rim of the northern crater, and are caused by collapse or subsidence after the impact event. Just to the south of this crater, 'rayed' patterns can be seen on part of the caldera floor. The rayed pattern is most likely due to a landslide of material down the crater rim slope. Another possibility is that the impact that formed the northern crater caused material to be ejected radially, and then parts of the ejecta have either been buried or eroded away. Other signs of mass movement events in this image are dark streaks, caused by dust avalanches, visible in the caldera's northern wall. In the central portion of the image, there are two lobe-shaped features-one overlaps the other-that appear to have flowed westward. It is likely that these features are ejecta lobes, because they are located adjacent to the southeastern crater (see context image). The fluidized appearance of these ejecta lobes is probably due to a significant amount of ice or water being present in the soil at the time of impact. We know that the southeastern crater must have formed after the northern crater, because the fluidized ejecta lobe overlies the rayed pattern. A close-up look at the fluidized ejecta lobes reveals a different surface 'texture' than the surrounding caldera floor. This could be due to compressional features that formed during the lobe emplacement, or to contrasting surface properties that cause the flows to be eroded differently than the caldera floor. In the lower portion of the image, there is a cluster of small circular features in the southernmost part of the central caldera. These features may be layered material that has since been eroded into circular plateaus, or they may be degraded volcanic cones, which would indicate a later stage of smaller-scale volcanism within the caldera. Volcanic cones are common in many calderas on Earth, and are formed after the initial stage of volcanic activity in that caldera. Finally, in the southern wall of the caldera, there is classic 'spur-and-gully' morphology. This type of morphology is often formed on steep slopes, where variations in wall resistance cause the surface to be eroded more easily in some areas.

Discovery of a Plains Caldera Complex and Extinct Lava Lake in Arabia Terra, Mars: Implications for the Discovery of Additional Highland Volcanic Source Regions

NASA Technical Reports Server (NTRS)

Bleacher, Jacob; Michalski, Joseph

2012-01-01

Several irregularly shaped topographic depressions occur near the dichotomy boundary in northern Arabia Terra, Mars. The geomorphology of these features suggests that they formed by collapse, opposed to meteor impact. At least one depression (approx.55 by 85 km) displays geologic features indicating a complex, multi-stage collapse history. Features within and around the collapse structure indicate volcanic processes. The complex occurs within Hesperian ridged plains of likely volcanic origin and displays no crater rim or evidence for ejecta. Instead the depression consists of a series of circumferential graben and down-dropped blocks which also display upper surfaces similar to ridged plain lavas. Large blocks within the depression are tilted towards the crater center, and display graben that appear to have originally been linked with circumferential graben outside of the complex related to earlier collapse events. A nearly 700 m high mound exists along a graben within the complex that might be a vent. The deepest depression displays two sets of nearly continuous terraces, which we interpret as high-stands of a drained lava lake. These features appear similar to the black ledge described during the Kilauea Iki eruption in 1959. A lacustrine origin for the terraces seems unlikely because of the paucity of channels found in or around the depression that could be linked to aqueous surface processes. In addition, there is no obvious evidence for lacustrine sediments within the basin. Together with the presence of significant faulting that is indicative of collapse we conclude that this crater complex represents a large caldera formed in the Late Noachian to Early Hesperian. Other linear and irregular depressions in the region also might be linked to ancient volcanism. If that hypothesis is correct, it suggests that northern Arabia Terra could contain a large, previously unrecognized highland igneous province. Evacuation of magma via explosive and effusive activity produced localized collapse, might have contributed to nearby ridged plains, and pyroclastic materials erupted from these vents might have supplied sediments in fretted terrain and other deposits. The recognition of volcanoes within Arabia Terra expands the known extent of Noachian-Hesperian volcanism to cover much of the preserved martian highland crust.

Assembling and compressing a semifluorinated alkane monolayer on a hydrophobic surface: Structural and dielectric properties

NASA Astrophysics Data System (ADS)

El Abed, Abdel I.; Ionov, Radoslav; Daoud, Mohamed; Abillon, Olivier

2004-11-01

We investigate the dynamic behavior upon lateral compression of a semifluorinated alkane F(CF2)8(CH2)18H (denoted F8H18 ), spread on the hydrophobic top of a suitable amphiphilic monolayer: namely, a natural α -helix alamethicin peptide (alam). We show, in particular, the formation of an asymmetric flat bilayer by compressing at the air-water interface a mixed Langmuir film made of F8H18 and alam. The particular chemical structure of F8H18 , the suitable structure of the underlying alam monolayer and its collapse properties, allow for a continuous compression of the upper F8H18 monolayer while the density of the lower alam monolayer remains constant. Combining grazing incidence x-ray reflectivity, surface potential, and atomic force microscopy data allow for the determination of the orientation and dielectric constant of the upper F8H18 monolayer.

Predictive Success Factors in Selective Upper Airway Stimulation.

PubMed

Heiser, Clemens; Hofauer, Benedikt

2017-01-01

Obstructive sleep apnea is one of the most common diseases in Western industrialized countries. A variety of conservative and surgical treatment options are available for its treatment. In recent years, selective upper airway stimulation (sUAS) has been shown to be effective and safe. Different biomarkers have been investigated as predictive clinical success factors in a number of clinical trials. Age does not matter in sUAS, as compared to its predictive role in other therapies. Weight seems to play a limited role, depending on drug-induced sleep endoscopy to rule out a complete concentric collapse with an increased body mass index. For surgical success and the related postoperative tongue motions, a nerve integrity monitoring methodology has been developed for predicting correct cuff placement. Postoperative sonography remains a promising method for the future assessment of predictive markers in sUAS. © 2017 S. Karger AG, Basel.

Electrotonic and action potentials in the Venus flytrap.

PubMed

Volkov, Alexander G; Vilfranc, Chrystelle L; Murphy, Veronica A; Mitchell, Colee M; Volkova, Maia I; O'Neal, Lawrence; Markin, Vladislav S

2013-06-15

The electrical phenomena and morphing structures in the Venus flytrap have attracted researchers since the nineteenth century. We have observed that mechanical stimulation of trigger hairs on the lobes of the Venus flytrap induces electrotonic potentials in the lower leaf. Electrostimulation of electrical circuits in the Venus flytrap can induce electrotonic potentials propagating along the upper and lower leaves. The instantaneous increase or decrease in voltage of stimulating potential generates a nonlinear electrical response in plant tissues. Any electrostimulation that is not instantaneous, such as sinusoidal or triangular functions, results in linear responses in the form of small electrotonic potentials. The amplitude and sign of electrotonic potentials depend on the polarity and the amplitude of the applied voltage. Electrical stimulation of the lower leaf induces electrical signals, which resemble action potentials, in the trap between the lobes and the midrib. The trap closes if the stimulating voltage is above the threshold level of 4.4V. Electrical responses in the Venus flytrap were analyzed and reproduced in the discrete electrical circuit. The information gained from this study can be used to elucidate the coupling of intracellular and intercellular communications in the form of electrical signals within plants. Copyright © 2013 Elsevier GmbH. All rights reserved.

[First case of lung abscess due to Yersinia pseudotuberculosis in Japan].

PubMed

Takahashi, Yoshinori; Sasabe, Jun; Maeda, Hikaru; Fujiwara, Atsushi; Yuda, Hisamichi; Yoshida, Masamichi; Taguchi, Osamu

2014-07-01

A 63-year-old previously healthy man was admitted to our hospital with diarrhea that had lasted for about 4 weeks, high fever and dyspnea. Chest computed tomography showed consolidation with a low-density area in the right middle lobe and small nodules with feeding vessels in the right upper lobe. On Day 8, a cavity was observed in the consolidation, and the lymph nodes in the mediastinum became necrotic. Yersinia pseudotuberculosis (serotype 4b) was cultured from blood, bronchial washing fluid, and lung tissue specimens. We diagnosed the lung lesions as septic pulmonary embolism caused by enterocolitis. We started treatment with tazobactam/piperacillin. It has been reported that high-dose ceftriaxone (CTRX) is effective, but CTRX at normal doses and other beta-lactams are less effective or even ineffective. Therefore, we changed to CTRX (4g/day) on Day 5, CTRX (2g/day) on Day 8, and oral cefditoren pivoxil (600 mg/day; a third-generation cephalosporin) on Day 18. Antibiotic therapy resulted in a favorable response. The patient was discharged from our hospital on day 25 in good health. To the best of our knowledge, this is the first case of a lung abscess caused by Y. pseudotuberculosis reported in Japan.

Two unusual organisms, Aspergillus terreus and Metschnikowia pulcherrima, associated with the lung disease of ankylosing spondylitis

PubMed Central

Kennedy, W. P. U.; Milne, L. J. R.; Blyth, W.; Crompton, G. K.

1972-01-01

Two male patients with ankylosing spondylitis and upper lobe fibrosis and cavitation are described. A pneumonic disease in one was associated with mycological and serological evidence of infection with Aspergillus terreus but no other aspergillus species. A large pulmonary mycetoma developed in the second patient and among a number of other fungal isolates was found the yeast Metschnikowia pulcherrima. The association of ankylosing spondylitis with bronchopulmonary aspergillosis is considered; A. terreus is described for the first time as a human pulmonary pathogen, and the possible pathogenicity of M. pulcherrima in the debilitated human subject is discussed. Images PMID:4628429

Interface extinction and subsurface peaking of the radiation pattern of a line source

NASA Technical Reports Server (NTRS)

Engheta, N.; Papas, C. H.; Elachi, C.

1981-01-01

The radiation pattern of a line source lying along the plane interface of two dielectric half-spaces is calculated. It is found that the pattern at the interface has a null (interface extinction); that the pattern in the upper half-space, whose index of refraction is taken to be less than that of the lower half-space, has a single lobe with a maximum normal to the interface; and that the pattern in the lower half-space (subsurface region) has two maxima (peaks) straddling symmetrically a minimum. Interpretation of these results in terms of ray optics, Oseen's extinction theorem, and the Cerenkov effect are given.

Navy Fan, California Borderland: Growth pattern and depositional processes

USGS Publications Warehouse

Normark, W.R.; Piper, D.J.W.

1984-01-01

Navy Fan is a Late Pleistocene sand-rich fan prograding into an irregularly shaped basin in the southern California Borderland. The middle fan, characterized by one active and two abandoned 'distributary' channels and associated lobe deposits, at present onlaps part of the basin slope directly opposite from the upper-fan valley, thus dividing the lower-fan/basin-plain regions into two separate parts of different depths. Fine-scale mesotopographic relief on the fan surface and correlation of individual turbidite beds through nearly 40 cores on the middle and lower fan provide data for evaluating the Late Pleistocene and Holocene depositional processes. ?? 1984 Springer-Verlag New York Inc.

Squamous cell carcinoma lung: Presented with bilateral lower limb deep venous thrombosis with gangrene formation

PubMed Central

Saha, Kaushik; Sengupta, Amitabha; Patra, Anupam; Jash, Debraj

2013-01-01

Bilateral venous thrombosis due to underlying malignancy is a rare entity. It is worthy to search for malignancy in patients of bilateral venous gangrene. Our patient presented with severe bilateral leg pain as a result of venous gangrene. There was associated left sided massive pleural effusion with scalp nodule. Fine needle aspiration cytology of scalp nodule revealed metastatic squamous cell carcinoma and fiber optic bronchoscopy guided biopsy from growth at left upper lobe bronchus confirmed the case as squamous cell carcinoma lung. It was rare for squamous cell carcinoma lung to present as bilateral venous gangrene with anticardiolipin antibody negative. PMID:24455526

Imaging-guided thoracoscopic resection of a ground-glass opacity lesion in a hybrid operating room equipped with a robotic C-arm CT system.

PubMed

Hsieh, Chen-Ping; Hsieh, Ming-Ju; Fang, Hsin-Yueh; Chao, Yin-Kai

2017-05-01

The intraoperative identification of small pulmonary nodules through video-assisted thoracoscopic surgery remains challenging. Although preoperative CT-guided nodule localization is commonly used to detect tumors during video-assisted thoracoscopic surgery (VATS), this approach carries inherent risks. We report the case of a patient with stage I lung cancer presenting as an area of ground-glass opacity (GGO) in the right upper pulmonary lobe. He successfully underwent a single-stage, CT-guided localization and removal of the pulmonary nodule within a hybrid operating room (OR) equipped with a robotic C-arm.

Lung salvage by pulmonary arterioplasty after vascular injury during video-assisted thoracoscopic surgical right upper lobectomy.

PubMed

Petel, M R; Mahieu, J; Baste, J M

2015-01-01

Video Assisted Thoracoscopic Surgical (VATS) lobectomy is now considered feasible and safe. Nevertheless, thoracic surgeons need to be aware of dramatic complications that may occur during this procedure and how best to manage them. We report the case of a severe tear of the right pulmonary artery (PA) during elective VATS upper lobectomy, leading to emergency conversion to control the bleeding. Initial arterial repair was performed by end-to-end anastomosis. Early CT angiography showed thrombosis of the right PA due to anastomotic stenosis. We performed emergency pulmonary arterioplasty with a prosthetic patch to save the right lung. A CT scan days after surgical lung salvage confirmed the permeability of the PA and normal vascularization of the two remaining right lobes. We discuss herein this dramatic complication of VATS lobectomy, the viability of the lung after pulmonary arterial thrombosis, and advocate for early postoperative imaging after pulmonary arterioplasty. Copyright© Acta Chirurgica Belgica.

Energy limits of electron acceleration in the plasma sheet during substorms: A case study with the Magnetospheric Multiscale (MMS) mission

NASA Astrophysics Data System (ADS)

Turner, D. L.; Fennell, J. F.; Blake, J. B.; Clemmons, J. H.; Mauk, B. H.; Cohen, I. J.; Jaynes, A. N.; Craft, J. V.; Wilder, F. D.; Baker, D. N.; Reeves, G. D.; Gershman, D. J.; Avanov, L. A.; Dorelli, J. C.; Giles, B. L.; Pollock, C. J.; Schmid, D.; Nakamura, R.; Strangeway, R. J.; Russell, C. T.; Artemyev, A. V.; Runov, A.; Angelopoulos, V.; Spence, H. E.; Torbert, R. B.; Burch, J. L.

2016-08-01

We present multipoint observations of earthward moving dipolarization fronts and energetic particle injections from NASA's Magnetospheric Multiscale mission with a focus on electron acceleration. From a case study during a substorm on 02 August 2015, we find that electrons are only accelerated over a finite energy range, from a lower energy threshold at 7-9 keV up to an upper energy cutoff in the hundreds of keV range. At energies lower than the threshold energy, electron fluxes decrease, potentially due to precipitation by strong parallel electrostatic wavefields or initial sources in the lobes. Electrons at energies higher than the threshold are accelerated cumulatively by a series of impulsive magnetic dipolarization events. This case demonstrates how the upper energy cutoff increases, in this case from 130 keV to >500 keV, with each dipolarization/injection during sustained activity. We also present a simple model accounting for these energy limits that reveals that electron energization is dominated by betatron acceleration.

Congenital Lobar Emphysema: An Approach of Anesthetic Management.

PubMed

Mourya, Meenakshi; Meena, Dharam Singh

2016-08-01

Congenital Lobar Emphysema (CLE) is a medical condition which is quiet rarely seen especially in neonates. The disease is characterized by over inflation of lungs which is produced due to inhibition of escape of inspired air from lungs. This condition usually occurs in infants due to partial obstruction of the bronchus and can be reversed with timely and planned anaesthetic management. Here in, we are presenting a case of an infant who was merely four months of age. CLE was affecting his left upper lobe since birth which was being treated as lobar pneumonia outside at some peripheral health center. The case presented to hospital with the symptoms acute respiratory distress and was taken up for urgent surgical management. Left upper lobectomy was performed which relived his symptoms. Case was discharged from hospital after 10 days of uneventful hospital stay. The case was challenging, as it involved careful and planned anaesthetic management of lung separation as well as prevention of hyperventilation of the un-involved lung.

Energy Limits of Electron Acceleration in the Plasma Sheet During Substorms: A Case Study with the Magnetospheric Multiscale (MMS) Mission

NASA Technical Reports Server (NTRS)

Turner, D. L.; Fennell, J. F.; Blake, J. B.; Clemmons, J. H.; Mauk, B. H.; Cohen, I. J.; Jaynes, A. N.; Craft, J. V.; Wilder, F. D.; Baker, D. N.;

Unique characteristics of the trachea of the juvenile leatherback turtle facilitate feeding, diving and endothermy

USGS Publications Warehouse

Davenport, John; Jones, T. Todd; Work, Thierry M.; Balazs, George H.

2014-01-01

The adult leatherback turtle Dermochelys coriacea overlaps in body size (300–500 kg) with many marine mammals, yet develops from a 50 g hatchling. Adults can dive deeper than 1200 m and have core body temperatures of 25 °C; hatchlings are near-surface dwellers. Juvenile leatherbacks have rarely been studied; here we present anatomical information for the upper respiratory tract of 3 turtles (66.7–83.0 cm straight carapace length; 33.2–53.4 kg body mass) incidentally captured by long-line fisheries. Combined with existing information from adults and hatchlings, our data show that there is an ontogenic shift in tracheal structure, with cartilaginous rings becoming broader and eventually fusing anteriorly. This ontogenic shift during independent existence is unique among extant deep-diving air breathing vertebrates. Tract wall thickness is graded, becoming progressively thinner from larynx to bronchi. In addition, cross-sectional shape becomes increasingly dorsoventrally flattened (more elliptical) from anterior to posterior. These characteristics ensure that the tract will collapse from posterior to anterior during dives. This study contains the first report of a double (= internally bifurcated) posterior section of the trachea; it is suggested that this allows continuous food movement along the esophagus without tracheal collapse. The whole upper respiratory tract (from larynx to lungs) has a vascular lining (thicker anteriorly than posteriorly) that appears to be a simple analog of the complex turbinates of birds and mammals. Our study confirmed that the leatherback tracheal structure represents a distinctive way of dealing with the challenges of diving in deep, cold sea water.

Distinct lobes of Limulus ventral photoreceptors. I. Functional and anatomical properties of lobes revealed by removal of glial cells

PubMed Central

1982-01-01

Removing the glial cells that encase Limulus ventral photoreceptors allows direct observation of the cell surface. Light microscopy of denuded photoreceptors reveals a subdivision of the cell body into lobes. Often one lobe, but sometimes several, is relatively clear and translucent (the R lobes). The lobe adjacent to the axon (the A lobe) has a textured appearance. Scanning electron microscopy shows that microvilli cover the surface of R lobes and are absent from the surface of A lobes. When a dim spot of light is incident on the R lobe, the probability of evoking a single photon response is two to three orders of magnitude higher than when the same spot is incident on the A lobe. We conclude that the sensitivity of the cell to light is principally a function of the R lobe. PMID:7175490

Arousal from sleep does not lead to reduced dilator muscle activity or elevated upper airway resistance on return to sleep in healthy individuals.

PubMed

Jordan, Amy S; Cori, Jennifer M; Dawson, Andrew; Nicholas, Christian L; O'Donoghue, Fergal J; Catcheside, Peter G; Eckert, Danny J; McEvoy, R Doug; Trinder, John

2015-01-01

To compare changes in end-tidal CO2, genioglossus muscle activity and upper airway resistance following tone-induced arousal and the return to sleep in healthy individuals with small and large ventilatory responses to arousal. Observational study. Two sleep physiology laboratories. 35 men and 25 women with no medical or sleep disorders. Auditory tones to induce 3-s to 15-s cortical arousals from sleep. During arousal from sleep, subjects with large ventilatory responses to arousal had higher ventilation (by analytical design) and tidal volume, and more marked reductions in the partial pressure of end-tidal CO2 compared to subjects with small ventilatory responses to arousal. However, following the return to sleep, ventilation, genioglossus muscle activity, and upper airway resistance did not differ between high and low ventilatory response groups (Breath 1 on return to sleep: ventilation 6.7±0.4 and 5.5±0.3 L/min, peak genioglossus activity 3.4%±1.0% and 4.8%±1.0% maximum, upper airway resistance 4.7±0.7 and 5.5±1.0 cm H2O/L/s, respectively). Furthermore, dilator muscle activity did not fall below the pre-arousal sleeping level and upper airway resistance did not rise above the pre-arousal sleeping level in either group for 10 breaths following the return to sleep. Regardless of the magnitude of the ventilatory response to arousal from sleep and subsequent reduction in PETCO2, healthy individuals did not develop reduced dilator muscle activity nor increased upper airway resistance, indicative of partial airway collapse, on the return to sleep. These findings challenge the commonly stated notion that arousals predispose to upper airway obstruction. © 2014 Associated Professional Sleep Societies, LLC.

Impact Cratering Processes as Understood Through Martian and Terrestrial Analog Studies

NASA Astrophysics Data System (ADS)

Caudill, C. M.; Osinski, G. R.; Tornabene, L. L.

2016-12-01

Impact ejecta deposits allow an understanding of subsurface lithologies, volatile content, and other compositional and physical properties of a planetary crust, yet development and emplacement of these deposits on terrestrial bodies throughout the solar system is still widely debated. Relating relatively well-preserved Martian ejecta to terrestrial impact deposits is an area of active research. In this study, we report on the mapping and geologic interpretation of 150-km diameter Bakhuysen Crater, Mars, which is likely large enough to have produced a significant volume of melt, and has uniquely preserved ejecta deposits. Our mapping supports the current formation hypothesis for Martian crater-related pitted material, where pits are likened to collapsed degassing features identified at the Ries and Haughton terrestrial impact structures. As hot impact melt-bearing ejecta deposits are emplaced over volatile-saturated material during crater formation, a rapid degassing of the underlying layer results in lapilli-like fluid and gas flow pipes which may eventually lead to collapse features on the surface. At the Haughton impact structure, degassing pipes are related to crater fracture and fault systems; this is analogous to structure and collapse pits mapped in Bakhuysen Crater. Based on stratigraphic superposition, surface and flow texture, and morphological and thermophysical mapping of Bakhuysen, we interpret the top-most ejecta unit to be likely melt-bearing and analogous to terrestrial impact deposits (e.g., Ries suevites). Furthermore, we suggest that Chicxulub is an apt terrestrial comparison based on its final diameter and the evidence of a ballistically-emplaced and volatile-entrained initial ejecta. This is significant as Bakhuysen ejecta deposits may provide insight into larger impact structures where limited exposures make studies difficult. This supports previous work which suggests that given similarities in volatile content and subsurface stratigraphy, mechanisms of multi-unit ejecta emplacement extend to impact cratering processes on comparable rocky bodies. The widespread pitted material, ejecta rampart and lobe formations, and distal debris flows associated with Bakhuysen impactite emplacement further indicates a volatile-rich Martian crust during its formation.

On thin ice/in hot water: Rapid drawdown of Wordie Ice Shelf glaciers in the decades after collapse in response to a changing ocean

NASA Astrophysics Data System (ADS)

Walker, C. C.; Gardner, A. S.

2016-12-01

Over the past 50 years, several Antarctic Peninsula ice shelves have retreated or collapsed completely. One such collapse was the Wordie Ice Shelf (WIS), located in Marguerite Bay, which began to disintegrate around 1989. We use several observational datasets to show that the glaciers that used to maintain WIS have experienced a surprising acceleration in flow ( 500m/yr) that began 2008, nearly 20 years after the onset of WIS collapse. During the same period, airborne altimetry from NASA Operation IceBridge shows the glaciers experienced a drawdown at their calving fronts between 4 and 9 m/yr, a near-doubling in rate of elevation change from the 1990's and early-2000's. The time lag between WIS collapse and rapid glacier drawdown suggests that these recent changes are unrelated to loss of buttressing. We identify possible links to changes in ocean conditions using in-situ Palmer Station Long-Term Ecological Research (PAL LTER) ocean CTD-gridded observations (Martinson et al., 2008) taken along the continental shelf on the west Antarctic Peninsula (WAP) since 1993. We use ECCO2 simulations and atmospheric reanalysis data to characterize changes in atmospheric forcing. We also measure changes in ice shelf area using historic archives and Landsat imagery for 50 glacier systems along the WAP from 1945 to present. Surface structural changes in the WIS system, e.g., melt ponds, sea/fast ice presence, and crevasse density/orientation, are also examined. We conclude that recent changes in WIS tributaries likely resulted from a significant increase in upwelling of warm, salty Upper Circumpolar Deep Water (UCDW) due to enhanced wind forcing following coincident global atmospheric oscillation events, namely a positive Southern Annular Mode and a moderate La Nina event. This enabled enhanced incursions of UCDW into Marguerite Bay between 2008-2014, in part due to the deep Marguerite Trough that connects the bay to the continental shelf break, along which the southern boundary of the Antarctic Circumpolar Current flows.

The complex emplacement dynamics and tsunami genesis of the 1888 Ritter Island sector collapse from 3D seismic data

NASA Astrophysics Data System (ADS)

Urlaub, M.; Karstens, J.; Berndt, C.; Watt, S. F.; Micallef, A.; Klaucke, I.; Klaeschen, D.; Brune, S.; Kühn, M.

2017-12-01

On March 13 1888, a large sector of the subaerial and submarine edifice of Ritter Island (Papua New Guinea) collapsed and slid into the Bismarck Sea, triggering a tsunami with run-up heights of more than 25 m on the neighboring islands. The tsunami traveled for more than 600 km and caused destruction in several settlements. German colonists described in detail the timing of the arriving waves. During research cruise SO252 onboard RV Sonne, we collected a comprehensive set of multibeam and sediment echosounder data, seafloor video footage, rock samples, 2D seismic profiles, and a 60 km2 high-resolution Pcable 3D seismic cube. This dataset, combined with the historic eyewitness accounts, allows detailed reconstruction of the large-scale volcanic sector collapse and the associated tsunami genesis. The 3D seismic cube reveals a change of emplacement dynamics during the collapse of the volcanic edifice. The initial failure occurred along a deep slide plane extending from the volcanic cone up to 300 m deep into the seafloor sediments adjacent to the volcanic edifice. Movement of large, intact sediment blocks and shortening characterize this deep-rooted mass-movement. In contrast to the well-preserved mobilization structures in the deep part of the volcanic edifice related to the initial phase of mass movement, there are hardly any deposits of the upper part of the volcanic cone comprising of well-stratified volcaniclastic layers. The 2 km3 cone was mobilized in the final stage of the sector collapse and its highly energetic slide mass eroded deeply into the previously emplaced slide deposits. The fast moving mass was channelized between two volcanic ridges, transported into the basin west of Sakar Island, and then deposited more than 30 km away from its source. We interpret the separation into two phases as the result of decoupling of the sliding mass of the cone from the deeper volcanic edifice. This process may be explained by gravitational acceleration of the sliding mass or a phreatomagmatic explosion due to the contact of the magmatic conduit with seawater.

Seafloor Morphology And Sediment Discharge Of The Storfjorden And Kveithola Palaeo-Ice Streams (NW Barents Sea) During The Last Deglaciation

NASA Astrophysics Data System (ADS)

Camerlenghi, Angelo; Rebesco, Michele; Pedrosa, Mayte; Demol, Ben; Giulia Lucchi, Renata; Urgeles, Roger; Colmenero-Hidalgo, Elena; Andreassen, Karin; Sverre Laberg, Jan; Winsborrow, Monica

2010-05-01

IPY Activity N. 367 focusing on Neogene ice streams and sedimentary processes on high- latitude continental margins (NICE-STREAMS) resulted in two coordinated cruises on the adjacent Storfjorden and Kveithola trough-mouth fans in the NW Barents Sea: SVAIS Cruise of BIO Hespérides, summer 2007, and EGLACOM Cruise of Cruise R/V OGS-Explora, summer 2008. The objectives were to acquire a high-resolution set of bathymetric, seismic and sediment core data in order to decipher the Neogene architectural development of the glacially-dominated NW Barents Sea continental margin in response to natural climate change. The paleo-ice streams drained ice from southern Spitsbergen, Spitsbergen Bank, and Bear Island. The short distance from the ice source to the calving front produced a short residence time of ice, and therefore a rapid response to climatic changes. In the outer trough of southern Storfjorden, lobate moraines superimpose and are cut by very large linear features attributed to mega-iceberg scours. In the adjacent Kveithola trough, a fresh morphology includes mega-scale glacial lineations overprinted by transverse grounding-zone wedges, diagnostic of episodic ice stream retreat. A 15 m thick glacimarine drape suggests an high post-deglaciation sedimentation rate. Preliminary interpretation suggests that the retreat of the Svalbard/Barents Sea Ice Sheet was highly dynamic and that grounded ice persisted on Spitsbergen Bank for some thousands years after the main Barents Sea deglaciation.The Storfjorden continental slope is divided into three wide lobes. Opposite the two northernmost lobes the slope is dominated by straight gullies in the upper part, and deposition of debris lobes on the mid and lower parts. In contrast, the southernmost lobe is characterized by widespread occurrence of submarine landslides. Sediment failure has accompanied the evolution of the southern Storfjorden and Kveithola margin throughout the Late Neogene, with very large mass transport deposits up to 200 m thick in the early phases of the development of the glacially influenced margin. Conversely, the central and northern parts of the Storfjorden margin have prograded without appreciable episodes of mass failure. Sedimentation has occurred through alternate layering of decimeter-thick glacial debris flows deposits, with laminated and acoustically transparent interglacial sediment drape. Gullies and paleo-gullies incise the glacial debris flows and are covered by the interglacial drape. They are formed early during each deglaciation phase, most likely by the erosive action of short-lived hyperpycnal flows generated by sediment-laden subglacial meltwater discharge. In sediment cores thick finely-laminated sedimentary beds on the upper continental slope of the southern part of the margin indicate preferential deposition by settlement of meltwater sediment plumes. High sedimentation rates of plumites may contribute to the slope instability and suggest that meltwater discharge was focused on the southern Storfjorden and Kveithola paleo-ice streams.

Timing and origin for sand dunes in the Green River Lowland of Illinois, upper Mississippi River Valley, USA

USGS Publications Warehouse

Miao, X.; Hanson, P.R.; Wang, Hongfang; Young, A.R.

2010-01-01

The recent increase in dune studies in North America has been heavily focused in the Great Plains, while less attention has historically been given to the dune fields east of the Mississippi River. Here we report ages and suggest a potential sediment source for sand dunes in the Green River Lowland, Illinois, which may provide a better understanding of the dynamic interactions between eolian, glacial, lacustrine and fluvial processes that shaped the landscapes of the upper Midwest. Seven coherent optically stimulated luminescence ages (OSL, or optical ages) obtained from four sites suggest that major dune construction in the Green River Lowland occurred within a narrow time window around 17,500 ago. This implies either an enhanced aridity or an episodic increase of sediment supply at 17,500 years ago, or combination of the both. Contrary to previous assertions that dune sand was sourced from the deflation of the underlying outwash sand deposited when the Lake Michigan Lobe retreated from the area, we propose that Green River Lowland dunes sand originated from the Green Bay Lobe through the Rock River. Specifically, sediment supply increased in the Rock River valley during drainage of Glacial Lake Scuppernong, which formed between ???18,000 and 17,000 years ago, when the Green Bay Lobe retreated from its terminal moraine. The lake drained catastrophically through the Rock River valley, providing glacial sediment and water to erode the preexisting sandy sediments. Throughout the remainder of the late Pleistocene, the Laurentide Ice Sheet drained into larger more northerly glacial lakes that in turn drained through other river valleys. Therefore, the dunes in the Green River Lowland formed only during the catastrophic drainage of Glacial Lake Scuppernong, but were stabilized through the remainder of the Pleistocene. This scenario explains the abrupt dune construction around 17,500 years ago, and explains the lack of later dune activity up to the Pleistocene-Holocene transition. OSL and radiocarbon ages also indicate that dunes were reactivated during the early, middle and late Holocene. Some eolian activation occurred within well-defined dry intervals in the upper Midwest, suggesting that increased aridity may have been the primary driver in mobilizing sand. However, many ages do not correspond to drier periods. In contrast to the relative coherency of the Pleistocene OSL ages from multiple study sites, the Holocene OSL ages do not overlap from one site to another, suggesting that increased aridity alone cannot explain the multiple phases of dune reactivation in the Holocene. Therefore, we conclude that the combined effect of localized disturbances and greater aridity acted in concert to increase eolian sand activity in the Holocene. The multiple periods of eolian activity during the Holocene suggest a high potential for future sand activation in the region, and these results are informative for environmental prediction and potential future mitigation.

Eradicating catastrophic collapse in interdependent networks via reinforced nodes

PubMed Central

Yuan, Xin; Hu, Yanqing; Havlin, Shlomo

2017-01-01

In interdependent networks, it is usually assumed, based on percolation theory, that nodes become nonfunctional if they lose connection to the network giant component. However, in reality, some nodes, equipped with alternative resources, together with their connected neighbors can still be functioning after disconnected from the giant component. Here, we propose and study a generalized percolation model that introduces a fraction of reinforced nodes in the interdependent networks that can function and support their neighborhood. We analyze, both analytically and via simulations, the order parameter—the functioning component—comprising both the giant component and smaller components that include at least one reinforced node. Remarkably, it is found that, for interdependent networks, we need to reinforce only a small fraction of nodes to prevent abrupt catastrophic collapses. Moreover, we find that the universal upper bound of this fraction is 0.1756 for two interdependent Erdős–Rényi (ER) networks: regular random (RR) networks and scale-free (SF) networks with large average degrees. We also generalize our theory to interdependent networks of networks (NONs). These findings might yield insight for designing resilient interdependent infrastructure networks. PMID:28289204

Search for long-lived gravitational-wave transients coincident with long gamma-ray bursts

NASA Astrophysics Data System (ADS)

Aasi, J.; Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T.; Abernathy, M. R.; Accadia, T.; Acernese, F.; Adams, C.; Adams, T.; Adhikari, R. X.; Affeldt, C.; Agathos, M.; Aggarwal, N.; Aguiar, O. D.; Ajith, P.; Allen, B.; Allocca, A.; Amador Ceron, E.; Amariutei, D.; Anderson, R. A.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Arceneaux, C.; Areeda, J.; Ast, S.; Aston, S. M.; Astone, P.; Aufmuth, P.; Aulbert, C.; Austin, L.; Aylott, B. E.; Babak, S.; Baker, P. T.; Ballardin, G.; Ballmer, S. W.; Barayoga, J. C.; Barker, D.; Barnum, S. H.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barton, M. A.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J.; Bauchrowitz, J.; Bauer, Th. S.; Bebronne, M.; Behnke, B.; Bejger, M.; Beker, M. G.; Bell, A. S.; Bell, C.; Belopolski, I.; Bergmann, G.; Berliner, J. M.; Bersanetti, D.; Bertolini, A.; Bessis, D.; Betzwieser, J.; Beyersdorf, P. T.; Bhadbhade, T.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Bitossi, M.; Bizouard, M. A.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Blom, M.; Bock, O.; Bodiya, T. P.; Boer, M.; Bogan, C.; Bond, C.; Bondu, F.; Bonelli, L.; Bonnand, R.; Bork, R.; Born, M.; Boschi, V.; Bose, S.; Bosi, L.; Bowers, J.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brannen, C. A.; Brau, J. E.; Breyer, J.; Briant, T.; Bridges, D. O.; Brillet, A.; Brinkmann, M.; Brisson, V.; Britzger, M.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brückner, F.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Calderón Bustillo, J.; Calloni, E.; Camp, J. B.; Campsie, P.; Cannon, K. C.; Canuel, B.; Cao, J.; Capano, C. D.; Carbognani, F.; Carbone, L.; Caride, S.; Castiglia, A.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C.; Cesarini, E.; Chakraborty, R.; Chalermsongsak, T.; Chao, S.; Charlton, P.; Chassande-Mottin, E.; Chen, X.; Chen, Y.; Chincarini, A.; Chiummo, A.; Cho, H. S.; Chow, J.; Christensen, N.; Chu, Q.; Chua, S. S. Y.; Chung, S.; Ciani, G.; Clara, F.; Clark, D. E.; Clark, J. A.; Cleva, F.; Coccia, E.; Cohadon, P.-F.; Colla, A.; Colombini, M.; Constancio, M., Jr.; Conte, A.; Conte, R.; Cook, D.; Corbitt, T. R.; Cordier, M.; Cornish, N.; Corsi, A.; Costa, C. A.; Coughlin, M. W.; Coulon, J.-P.; Countryman, S.; Couvares, P.; Coward, D. M.; Cowart, M.; Coyne, D. C.; Craig, K.; Creighton, J. D. E.; Creighton, T. D.; Crowder, S. G.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dahl, K.; Dal Canton, T.; Damjanic, M.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dattilo, V.; Daudert, B.; Daveloza, H.; Davier, M.; Davies, G. S.; Daw, E. J.; Day, R.; Dayanga, T.; De Rosa, R.; Debreczeni, G.; Degallaix, J.; Del Pozzo, W.; Deleeuw, E.; Deléglise, S.; Denker, T.; Dent, T.; Dereli, H.; Dergachev, V.; DeRosa, R.; DeSalvo, R.; Dhurandhar, S.; Di Fiore, L.; Di Lieto, A.; Di Palma, I.; Di Virgilio, A.; Díaz, M.; Dietz, A.; Dmitry, K.; Donovan, F.; Dooley, K. L.; Doravari, S.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Du, Z.; Dumas, J.-C.; Dwyer, S.; Eberle, T.; Edwards, M.; Effler, A.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Endrőczi, G.; Essick, R.; Etzel, T.; Evans, K.; Evans, M.; Evans, T.; Factourovich, M.; Fafone, V.; Fairhurst, S.; Fang, Q.; Farinon, S.; Farr, B.; Farr, W.; Favata, M.; Fazi, D.; Fehrmann, H.; Feldbaum, D.; Ferrante, I.; Ferrini, F.; Fidecaro, F.; Finn, L. S.; Fiori, I.; Fisher, R.; Flaminio, R.; Foley, E.; Foley, S.; Forsi, E.; Fotopoulos, N.; Fournier, J.-D.; Franco, S.; Frasca, S.; Frasconi, F.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Fritschel, P.; Frolov, V. V.; Fujimoto, M.-K.; Fulda, P.; Fyffe, M.; Gair, J.; Gammaitoni, L.; Garcia, J.; Garufi, F.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; Gergely, L.; Ghosh, S.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Giazotto, A.; Gil-Casanova, S.; Gill, C.; Gleason, J.; Goetz, E.; Goetz, R.; Gondan, L.; González, G.; Gordon, N.; Gorodetsky, M. L.; Gossan, S.; Goßler, S.; Gouaty, R.; Graef, C.; Graff, P. B.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Griffo, C.; Groot, P.; Grote, H.; Grover, K.; Grunewald, S.; Guidi, G. M.; Guido, C.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hall, B.; Hall, E.; Hammer, D.; Hammond, G.; Hanke, M.; Hanks, J.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Hartman, M. T.; Haughian, K.; Hayama, K.; Heefner, J.; Heidmann, A.; Heintze, M.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Holt, K.; Holtrop, M.; Hong, T.; Hooper, S.; Horrom, T.; Hosken, D. J.; Hough, J.; Howell, E. J.; Hu, Y.; Hua, Z.; Huang, V.; Huerta, E. A.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh, M.; Huynh-Dinh, T.; Iafrate, J.; Ingram, D. R.; Inta, R.; Isogai, T.; Ivanov, A.; Iyer, B. R.; Izumi, K.; Jacobson, M.; James, E.; Jang, H.; Jang, Y. J.; Jaranowski, P.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Haris, K.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kasprzack, M.; Kasturi, R.; Katsavounidis, E.; Katzman, W.; Kaufer, H.; Kaufman, K.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kéfélian, F.; Keitel, D.; Kelley, D. B.; Kells, W.; Keppel, D. G.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, B. K.; Kim, C.; Kim, K.; Kim, N.; Kim, W.; Kim, Y.-M.; King, E. J.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kline, J.; Koehlenbeck, S.; Kokeyama, K.; Kondrashov, V.; Koranda, S.; Korth, W. Z.; Kowalska, I.; Kozak, D.; Kremin, A.; Kringel, V.; Królak, A.; Kucharczyk, C.; Kudla, S.; Kuehn, G.; Kumar, A.; Kumar, P.; Kumar, R.; Kurdyumov, R.; Kwee, P.; Landry, M.; Lantz, B.; Larson, S.; Lasky, P. D.; Lawrie, C.; Lazzarini, A.; Le Roux, A.; Leaci, P.; Lebigot, E. O.; Lee, C.-H.; Lee, H. K.; Lee, H. M.; Lee, J.; Lee, J.; Leonardi, M.; Leong, J. R.; Leroy, N.; Letendre, N.; Levine, B.; Lewis, J. B.; Lhuillier, V.; Li, T. G. F.; Lin, A. C.; Littenberg, T. B.; Litvine, V.; Liu, F.; Liu, H.; Liu, Y.; Liu, Z.; Lloyd, D.; Lockerbie, N. A.; Lockett, V.; Lodhia, D.; Loew, K.; Logue, J.; Lombardi, A. L.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J.; Luan, J.; Lubinski, M. J.; Lück, H.; Lundgren, A. P.; Macarthur, J.; Macdonald, E.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magana-Sandoval, F.; Mageswaran, M.; Mailand, K.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Manca, G. M.; Mandel, I.; Mandic, V.; Mangano, V.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markosyan, A.; Maros, E.; Marque, J.; Martelli, F.; Martin, I. W.; Martin, R. M.; Martinelli, L.; Martynov, D.; Marx, J. N.; Mason, K.; Masserot, A.; Massinger, T. J.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; May, G.; Mazumder, N.; Mazzolo, G.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McIntyre, G.; McIver, J.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Meier, T.; Melatos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miao, H.; Michel, C.; Mikhailov, E. E.; Milano, L.; Miller, J.; Minenkov, Y.; Mingarelli, C. M. F.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moe, B.; Mohan, M.; Mohapatra, S. R. P.; Mokler, F.; Moraru, D.; Moreno, G.; Morgado, N.; Mori, T.; Morriss, S. R.; Mossavi, K.; Mours, B.; Mow-Lowry, C. M.; Mueller, C. L.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Munch, J.; Murphy, D.; Murray, P. G.; Mytidis, A.; Nagy, M. F.; Nanda Kumar, D.; Nardecchia, I.; Nash, T.; Naticchioni, L.; Nayak, R.; Necula, V.; Nelemans, G.; Neri, I.; Neri, M.; Newton, G.; Nguyen, T.; Nishida, E.; Nishizawa, A.; Nitz, A.; Nocera, F.; Nolting, D.; Normandin, M. E.; Nuttall, L. K.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Oppermann, P.; O'Reilly, B.; Ortega Larcher, W.; O'Shaughnessy, R.; Osthelder, C.; Ott, C. D.; Ottaway, D. J.; Ottens, R. S.; Ou, J.; Overmier, H.; Owen, B. J.; Padilla, C.; Pai, A.; Palomba, C.; Pan, Y.; Pankow, C.; Paoletti, F.; Paoletti, R.; Papa, M. A.; Paris, H.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Pedraza, M.; Peiris, P.; Penn, S.; Perreca, A.; Phelps, M.; Pichot, M.; Pickenpack, M.; Piergiovanni, F.; Pierro, V.; Pinard, L.; Pindor, B.; Pinto, I. M.; Pitkin, M.; Poeld, J.; Poggiani, R.; Poole, V.; Poux, C.; Predoi, V.; Prestegard, T.; Price, L. R.; Prijatelj, M.; Principe, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L.; Puncken, O.; Punturo, M.; Puppo, P.; Quetschke, V.; Quintero, E.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Rácz, I.; Radkins, H.; Raffai, P.; Raja, S.; Rajalakshmi, G.; Rakhmanov, M.; Ramet, C.; Rapagnani, P.; Raymond, V.; Re, V.; Reed, C. M.; Reed, T.; Regimbau, T.; Reid, S.; Reitze, D. H.; Ricci, F.; Riesen, R.; Riles, K.; Robertson, N. A.; Robinet, F.; Rocchi, A.; Roddy, S.; Rodriguez, C.; Rodruck, M.; Roever, C.; Rolland, L.; Rollins, J. G.; Romano, J. D.; Romano, R.; Romanov, G.; Romie, J. H.; Rosińska, D.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Ryan, K.; Salemi, F.; Sammut, L.; Sandberg, V.; Sanders, J.; Sannibale, V.; Santiago-Prieto, I.; Saracco, E.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Savage, R.; Schilling, R.; Schnabel, R.; Schofield, R. M. S.; Schreiber, E.; Schuette, D.; Schulz, B.; Schutz, B. F.; Schwinberg, P.; Scott, J.; Scott, S. M.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sergeev, A.; Shaddock, D.; Shah, S.; Shahriar, M. S.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Shoemaker, D. H.; Sidery, T. L.; Siellez, K.; Siemens, X.; Sigg, D.; Simakov, D.; Singer, A.; Singer, L.; Sintes, A. M.; Skelton, G. R.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Smith, R. J. E.; Smith-Lefebvre, N. D.; Soden, K.; Son, E. J.; Sorazu, B.; Souradeep, T.; Sperandio, L.; Staley, A.; Steinert, E.; Steinlechner, J.; Steinlechner, S.; Steplewski, S.; Stevens, D.; Stochino, A.; Stone, R.; Strain, K. A.; Straniero, N.; Strigin, S.; Stroeer, A. S.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Susmithan, S.; Sutton, P. J.; Swinkels, B.; Szeifert, G.; Tacca, M.; Talukder, D.; Tang, L.; Tanner, D. B.; Tarabrin, S. P.; Taylor, R.; ter Braack, A. P. M.; Thirugnanasambandam, M. P.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Tiwari, V.; Tokmakov, K. V.; Tomlinson, C.; Toncelli, A.; Tonelli, M.; Torre, O.; Torres, C. V.; Torrie, C. I.; Travasso, F.; Traylor, G.; Tse, M.; Ugolini, D.; Unnikrishnan, C. S.; Vahlbruch, H.; Vajente, G.; Vallisneri, M.; van den Brand, J. F. J.; Van Den Broeck, C.; van der Putten, S.; van der Sluys, M. V.; van Heijningen, J.; van Veggel, A. A.; Vass, S.; Vasúth, M.; Vaulin, R.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Verkindt, D.; Verma, S.; Vetrano, F.; Viceré, A.; Vincent-Finley, R.; Vinet, J.-Y.; Vitale, S.; Vlcek, B.; Vo, T.; Vocca, H.; Vorvick, C.; Vousden, W. D.; Vrinceanu, D.; Vyachanin, S. P.; Wade, A.; Wade, L.; Wade, M.; Waldman, S. J.; Walker, M.; Wallace, L.; Wan, Y.; Wang, J.; Wang, M.; Wang, X.; Wanner, A.; Ward, R. L.; Was, M.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Welborn, T.; Wen, L.; Wessels, P.; West, M.; Westphal, T.; Wette, K.; Whelan, J. T.; Whitcomb, S. E.; White, D. J.; Whiting, B. F.; Wibowo, S.; Wiesner, K.; Wilkinson, C.; Williams, L.; Williams, R.; Williams, T.; Willis, J. L.; Willke, B.; Wimmer, M.; Winkelmann, L.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Worden, J.; Yablon, J.; Yakushin, I.; Yamamoto, H.; Yancey, C. C.; Yang, H.; Yeaton-Massey, D.; Yoshida, S.; Yum, H.; Yvert, M.; Zadrożny, A.; Zanolin, M.; Zendri, J.-P.; Zhang, F.; Zhang, L.; Zhao, C.; Zhu, H.; Zhu, X. J.; Zotov, N.; Zucker, M. E.; Zweizig, J.

2013-12-01

Long gamma-ray bursts (GRBs) have been linked to extreme core-collapse supernovae from massive stars. Gravitational waves (GW) offer a probe of the physics behind long GRBs. We investigate models of long-lived (˜10-1000s) GW emission associated with the accretion disk of a collapsed star or with its protoneutron star remnant. Using data from LIGO’s fifth science run, and GRB triggers from the Swift experiment, we perform a search for unmodeled long-lived GW transients. Finding no evidence of GW emission, we place 90% confidence-level upper limits on the GW fluence at Earth from long GRBs for three waveforms inspired by a model of GWs from accretion disk instabilities. These limits range from F<3.5ergscm-2 to F<1200ergscm-2, depending on the GRB and on the model, allowing us to probe optimistic scenarios of GW production out to distances as far as ≈33Mpc. Advanced detectors are expected to achieve strain sensitivities 10× better than initial LIGO, potentially allowing us to probe the engines of the nearest long GRBs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cataneo, Matteo; Rapetti, David; Lombriser, Lucas

We refine the mass and environment dependent spherical collapse model of chameleon f ( R ) gravity by calibrating a phenomenological correction inspired by the parameterized post-Friedmann framework against high-resolution N -body simulations. We employ our method to predict the corresponding modified halo mass function, and provide fitting formulas to calculate the enhancement of the f ( R ) halo abundance with respect to that of General Relativity (GR) within a precision of ∼< 5% from the results obtained in the simulations. Similar accuracy can be achieved for the full f ( R ) mass function on the condition thatmore » the modeling of the reference GR abundance of halos is accurate at the percent level. We use our fits to forecast constraints on the additional scalar degree of freedom of the theory, finding that upper bounds competitive with current Solar System tests are within reach of cluster number count analyses from ongoing and upcoming surveys at much larger scales. Importantly, the flexibility of our method allows also for this to be applied to other scalar-tensor theories characterized by a mass and environment dependent spherical collapse.« less

Anatomy of the Chesapeake Bay impact structure revealed by seismic imaging, Delmarva Peninsula, Virginia, USA

USGS Publications Warehouse

Catchings, R.D.; Powars, D.S.; Gohn, G.S.; Horton, J. Wright; Goldman, M.R.; Hole, J.A.

2008-01-01

A 30-km-long, radial seismic reflection and refraction survey completed across the northern part of the late Eocene Chesapeake Bay impact structure (CBIS) on the Delmarva Peninsula, Virginia, USA, confirms that the CBIS is a complex central-peak crater. We used a tomographic P wave velocity model and low-fold reflection images, constrained by data from two deep boreholes located on the profile, to interpret the structure and composition of the upper 5 km of crust. The seismic images exhibit well-defined structural features, including (with increasing radial distance) a collapsed central uplift, a breccia-filled moat, and a collapsed transient-crater margin (which collectively constitute a ???40-km-wide collapsed transient crater), and a shallowly deformed annular trough. These seismic images are the first to resolve the deep structure of the crater (>1 km) and the boundaries between the central uplift, moat, and annular trough. Several distinct seismic signatures distinguish breccia units from each other and from more coherent crystalline rocks below the central uplift, moat, and annular trough. Within the moat, breccia extends to a minimum depth of 1.5 km or a maximum of 3.5 km, depending upon the interpretation of the deepest layered materials. The images show ???350 to 500 m of postimpact sediments above the impactites. The imaged structure of the CBIS indicates a complex sequence of event during the cratering process that will provide new constraints for numerical modeling. Copyright 2008 by the American Geophysical Union.

Roche-lobe overflow systems powered by black holes in young star clusters: the importance of dynamical exchanges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mapelli, Michela; Zampieri, Luca, E-mail: michela.mapelli@oapd.inaf.it

2014-10-10

We have run 600 N-body simulations of intermediate-mass (∼3500 M {sub ☉}) young star clusters (SCs; with three different metallicities (Z = 0.01, 0.1, and 1 Z {sub ☉}). The simulations include the dependence of stellar properties and stellar winds on metallicity. Massive stellar black holes (MSBHs) with mass >25 M {sub ☉} are allowed to form through direct collapse of very massive metal-poor stars (Z < 0.3 Z {sub ☉}). We focus on the demographics of black hole (BH) binaries that undergo mass transfer via Roche lobe overflow (RLO). We find that 44% of all binaries that undergo anmore » RLO phase (RLO binaries) formed through dynamical exchange. RLO binaries that formed via exchange (RLO-EBs) are powered by more massive BHs than RLO primordial binaries (RLO-PBs). Furthermore, the RLO-EBs tend to start the RLO phase later than the RLO-PBs. In metal-poor SCs (0.01-0.1 Z {sub ☉}), >20% of all RLO binaries are powered by MSBHs. The vast majority of RLO binaries powered by MSBHs are RLO-EBs. We have produced optical color-magnitude diagrams of the simulated RLO binaries, accounting for the emission of both the donor star and the irradiated accretion disk. We find that RLO-PBs are generally associated with bluer counterparts than RLO-EBs. We compare the simulated counterparts with the observed counterparts of nine ultraluminous X-ray sources. We discuss the possibility that IC 342 X-1, Ho IX X-1, NGC 1313 X-2, and NGC 5204 X-1 are powered by an MSBH.« less

A high resolution computer tomography scoring system to predict culture-positive pulmonary tuberculosis in the emergency department.

PubMed

Yeh, Jun-Jun; Neoh, Choo-Aun; Chen, Cheng-Ren; Chou, Christine Yi-Ting; Wu, Ming-Ting

2014-01-01

This study evaluated the use of high-resolution computed tomography (HRCT) to predict the presence of culture-positive pulmonary tuberculosis (PTB) in adult patients with pulmonary lesions in the emergency department (ED). The study included a derivation phase and validation phase with a total of 8,245 patients with pulmonary disease. There were 132 patients with culture-positive PTB in the derivation phase and 147 patients with culture-positive PTB in the validation phase. Imaging evaluation of pulmonary lesions included morphology and segmental distribution. The post-test probability ratios between both phases in three prevalence areas were analyzed. In the derivation phase, a multivariate analysis model identified cavitation, consolidation, and clusters/nodules in right or left upper lobe (except anterior segment) and consolidation of the superior segment of the right or left lower lobe as independent positive factors for culture-positive PTB, while consolidation of the right or left lower lobe (except superior segment) were independent negative factors. An ideal cutoff point based on the receiver operating characteristic (ROC) curve analysis was obtained at a score of 1. The sensitivity, specificity, positivity predictive value, and negative predictive value from derivation phase were 98.5% (130/132), 99.7% (3997/4008), 92.2% (130/141), and 99.9% (3997/3999). Based on the predicted positive likelihood ratio value of 328.33 in derivation phase, the post-test probability was observed to be 91.5% in the derivation phase, 92.5% in the validation phase, 94.5% in a high TB prevalence area, 91.0% in a moderate prevalence area, and 76.8% in moderate-to-low prevalence area. Our model using HRCT, which is feasible to perform in the ED, can promptly diagnose culture-positive PTB in moderate and moderate-to-low prevalence areas.

Shallow gas reservoir in a Pleistocene transgressive sand sheet developed during the drowning of retrograde delta lobes, Louisiana continental shelf

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flakes, L.G.; Fillon, R.H.

1996-12-31

A strongly negative seismic amplitude discovered in our 3-D data set at 450 ms has been tied to the interface marking the top of a thick sand section ca. -1300 ft sub-sea. Sequence stratigraphic and stacking pattern analysis of SP and GR logs point to a Late Pleistocene low-stand delta bar origin for the thick, blocky sands in the lower part of the section. Resistivity data shows the delta bar sands are wet with salt water while an uppermost, thin sand member, capped by shale constituting a notable flooding surface, and potential vertical seal, exhibited a high resistivity signature. Withmore » other evidence, this is considered to reflect the presence of free gas in the sand`s pore spaces. An amplitude extraction made to evaluate the reservoir potential of the gas-charged sand member revealed a pattern consistent with three, deltaic lobes aligned along a former drainage axis. The mapped features are considered the result of retrograde delta migration and geomorphic evolution in response to rising sea levels late in the low stand. The upper, gas-charged sand member was interpreted, based on modern analogs, as a transgressive sand sheet containing a combination of facies related to the sub-environments of delta lobe destruction and flooding during rapid marine transgression, e.g.: re-worked barrier island; marine sand shoal; and, inner neuritic shelf sands. The Chandeleur Islands and Ship Shoal are modern examples of these features. Because of the relatively thin but widespread character and good sand quality expected for a transgressive sand sheet, this prospect was selected as a low-risk, low-cost candidate for horizontal drilling and completion.« less

Shallow gas reservoir in a Pleistocene transgressive sand sheet developed during the drowning of retrograde delta lobes, Louisiana continental shelf

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flakes, L.G.; Fillon, R.H.

1996-01-01

A strongly negative seismic amplitude discovered in our 3-D data set at 450 ms has been tied to the interface marking the top of a thick sand section ca. -1300 ft sub-sea. Sequence stratigraphic and stacking pattern analysis of SP and GR logs point to a Late Pleistocene low-stand delta bar origin for the thick, blocky sands in the lower part of the section. Resistivity data shows the delta bar sands are wet with salt water while an uppermost, thin sand member, capped by shale constituting a notable flooding surface, and potential vertical seal, exhibited a high resistivity signature. Withmore » other evidence, this is considered to reflect the presence of free gas in the sand's pore spaces. An amplitude extraction made to evaluate the reservoir potential of the gas-charged sand member revealed a pattern consistent with three, deltaic lobes aligned along a former drainage axis. The mapped features are considered the result of retrograde delta migration and geomorphic evolution in response to rising sea levels late in the low stand. The upper, gas-charged sand member was interpreted, based on modern analogs, as a transgressive sand sheet containing a combination of facies related to the sub-environments of delta lobe destruction and flooding during rapid marine transgression, e.g.: re-worked barrier island; marine sand shoal; and, inner neuritic shelf sands. The Chandeleur Islands and Ship Shoal are modern examples of these features. Because of the relatively thin but widespread character and good sand quality expected for a transgressive sand sheet, this prospect was selected as a low-risk, low-cost candidate for horizontal drilling and completion.« less

On the population of remnant Fanaroff-Riley type II radio galaxies and implications for radio source dynamics

NASA Astrophysics Data System (ADS)

Godfrey, L. E. H.; Morganti, R.; Brienza, M.

2017-10-01

The purpose of this work is two-fold: (1) to quantify the occurrence of ultrasteep spectrum remnant Fanaroff-Riley type II (FRII) radio galaxies in a 74 MHz flux-limited sample, and (2) perform Monte Carlo simulations of the population of active and remnant FRII radio galaxies to confront models of remnant lobe evolution, and to provide guidance for further investigation of remnant radio galaxies. We find that fewer than 2 per cent of FRII radio galaxies with S74 MHz > 1.5 Jy are candidate ultrasteep spectrum remnants, where we define ultrasteep spectrum as α _74 MHz^1400 MHz > 1.2. Our Monte Carlo simulations demonstrate that models involving Sedov-like expansion in the remnant phase, resulting in rapid adiabatic energy losses, are consistent with this upper limit, and predict the existence of nearly twice as many remnants with normal (not ultrasteep) spectra in the observed frequency range as there are ultrasteep spectrum remnants. This model also predicts an ultrasteep remnant fraction approaching 10 per cent at redshifts z < 0.5. Importantly, this model implies the lobes remain overpressured with respect to the ambient medium well after their active lifetime, in contrast with existing observational evidence that many FRII radio galaxy lobes reach pressure equilibrium with the external medium whilst still in the active phase. The predicted age distribution of remnants is a steeply decreasing function of age. In other words, young remnants are expected to be much more common than old remnants in flux-limited samples. For this reason, incorporating higher frequency data ≳5 GHz will be of great benefit to future studies of the remnant population.

MAVEN observations of complex magnetic field configuration in the Martian magnetotail

NASA Astrophysics Data System (ADS)

DiBraccio, G. A.; Luhmann, J. G.; Curry, S.; Espley, J. R.; Gruesbeck, J.; Xu, S.; Mitchell, D. L.; Soobiah, Y. I. J.; Connerney, J. E. P.; Dong, C.; Harada, Y.; Ruhunusiri, S.; Halekas, J. S.; Hara, T.; Ma, Y.; Brain, D.; Jakosky, B. M.

2017-12-01

The magnetosphere of Mars has attributes of both induced and intrinsic magnetospheres, forming as a result of direct solar wind interaction with the planet's upper atmosphere and local crustal magnetic fields. Magnetic reconnection is able to occur between the draped interplanetary magnetic field (IMF) and closed crustal magnetic fields, creating an open field topology with one end attached to the planet and the other flowing in the solar wind. For this reason, the Martian magnetotail becomes a complex menagerie of various field topologies that may contribute to atmospheric escape to space. We explore these magnetic topologies in the Martian magnetotail using a combination of observations from the the Mars Atmosphere Volatile EvolutioN (MAVEN) spacecraft along with magnetohydrodynamic (MHD) simulations. Preliminary MHD results suggest that the central tail contains two lobes composed of open crustal fields, which are twisted by roughly 45°, either clockwise or counterclockwise from the ecliptic plane, in response to the east-west component of the IMF. These simulated open-field lobes are enveloped by an induced comet-like tail formed by the draped IMF. Using two Earth years of data, we analyze MAVEN Magnetometer and Solar Wind Ion Analyzer (SWIA) measurements to assess the tail magnetic field configuration as a function of IMF orientation. We infer, through data-model comparisons, that the open-field tail lobes are likely a result of reconnection between the crustal fields and the IMF. The open topology of these fields may in fact contribute to atmospheric loss to space. This investigation confirms that the Martian magnetotail is a hybrid configuration between intrinsic and induced magnetospheres, shifting the paradigm of Mars' magnetosphere as we have understood it thus far.

Altered temporal lobe white matter lipid ion profiles in an experimental model of sporadic Alzheimer's disease.

PubMed

Tong, Ming; Leão, Raiane; Vimbela, Gina V; Yalcin, Emine B; Kay, Jared; Krotow, Alexander; de la Monte, Suzanne M

2017-07-01

White matter is an early and important yet under-evaluated target of Alzheimer's disease (AD). Metabolic impairments due to insulin and insulin-like growth factor resistance contribute to white matter degeneration because corresponding signal transduction pathways maintain oligodendrocyte function and survival. This study utilized a model of sporadic AD in which adult Long Evans rats administered intracerebral streptozotocin (i.c. STZ) developed AD-type neurodegeneration. Temporal lobe white matter lipid ion profiles were characterized by matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). Although the lipid ion species expressed in the i.c. STZ and control groups were virtually identical, i.c. STZ mainly altered the abundances of various lipid ions. Correspondingly, the i.c. STZ group was distinguished from control by principal component analysis and data bar plots. i.c. STZ mainly reduced expression of lipid ions with low m/z's (less than 810) as well as the upper range m/z lipids (m/z 964-986), and increased expression of lipid ions with m/z's between 888 and 937. Phospholipids were mainly included among the clusters inhibited by i.c. STZ, while both sulfatides and phospholipids were increased by i.c. STZ. However, Chi-Square analysis demonstrated significant i.c. STZ-induced trend reductions in phospholipids and increases in sulfatides (P<0.00001). The i.c. STZ model of sporadic AD is associated with broad and sustained abnormalities in temporal lobe white matter lipids. The findings suggest that the i.c. STZ model could be used for pre-clinical studies to assess therapeutic measures for their ability to restore white matter integrity in AD. Copyright © 2017 Elsevier Inc. All rights reserved.

CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus.

PubMed

Das, Karuna M; Lee, Edward Y; Enani, Mushira A; AlJawder, Suhaila E; Singh, Rajvir; Bashir, Salman; Al-Nakshbandi, Nizar; AlDossari, Khalid; Larsson, Sven G

2015-04-01

The purpose of this article is to retrospectively analyze chest CT findings for 15 patients with Middle East respiratory syndrome coronavirus and to identify features associated with survival. Patients were assigned to group 1 if they died (n=9) and to group 2 if they made a full recovery (n=6). Two reviewers scored chest radiographs and CT examinations for segmental involvement, ground-glass opacities, consolidation, and interstitial thickening. Eight patients had ground-glass opacity (53%), five had ground-glass and consolidation in combination (33%), five had pleural effusion (33%), and four patients had interlobular thickening (27%). Of 281 CT findings, 151 (54%) were peripheral, 68 (24%) were central, and 62 (22%) had a mixed location. The number of involved lung segments was higher in group 1. The lower lobe was more commonly involved (mean, 12.2 segments) than in the upper and middle lobes combined (mean, 6.3 segments). The mean number of lung segments involved was 12.3 segments in group 1 and 3.4 segments in group 2. The CT lung score (mean±SD, 15.78±7.9 vs 7.3±5.7, p=0.003), chest radiographic score (20.8±1.7 vs 5.6±5.4; p=0.001), and mechanical ventilation duration (13.11±8.3 vs 0.5±1.2 days; p=0.002) were higher in group 1. All nine group 1 patients and three of six group 2 patients had pleural effusion (p=0.52). CT of patients with Middle East respiratory syndrome coronavirus predominantly showed ground-glass opacities, with peripheral lower lobe preference. Pleural effusion and higher CT lung and chest radiographic scores correlate with poor prognosis and short-term mortality.

Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography

PubMed Central

Iwano, Shingo; Kitano, Mariko; Matsuo, Keiji; Kawakami, Kenichi; Koike, Wataru; Kishimoto, Mariko; Inoue, Tsutomu; Li, Yuanzhong; Naganawa, Shinji

2013-01-01

OBJECTIVES To compare the accuracy of pulmonary lobar volumetry using the conventional number of segments method and novel volumetric computer-aided diagnosis using 3D computed tomography images. METHODS We acquired 50 consecutive preoperative 3D computed tomography examinations for lung tumours reconstructed at 1-mm slice thicknesses. We calculated the lobar volume and the emphysematous lobar volume < −950 HU of each lobe using (i) the slice-by-slice method (reference standard), (ii) number of segments method, and (iii) semi-automatic and (iv) automatic computer-aided diagnosis. We determined Pearson correlation coefficients between the reference standard and the three other methods for lobar volumes and emphysematous lobar volumes. We also compared the relative errors among the three measurement methods. RESULTS Both semi-automatic and automatic computer-aided diagnosis results were more strongly correlated with the reference standard than the number of segments method. The correlation coefficients for automatic computer-aided diagnosis were slightly lower than those for semi-automatic computer-aided diagnosis because there was one outlier among 50 cases (2%) in the right upper lobe and two outliers among 50 cases (4%) in the other lobes. The number of segments method relative error was significantly greater than those for semi-automatic and automatic computer-aided diagnosis (P < 0.001). The computational time for automatic computer-aided diagnosis was 1/2 to 2/3 than that of semi-automatic computer-aided diagnosis. CONCLUSIONS A novel lobar volumetry computer-aided diagnosis system could more precisely measure lobar volumes than the conventional number of segments method. Because semi-automatic computer-aided diagnosis and automatic computer-aided diagnosis were complementary, in clinical use, it would be more practical to first measure volumes by automatic computer-aided diagnosis, and then use semi-automatic measurements if automatic computer-aided diagnosis failed. PMID:23526418

Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study

PubMed Central

Bonelli, Silvia B.; Thompson, Pamela J.; Yogarajah, Mahinda; Powell, Robert H. W.; Samson, Rebecca S.; McEvoy, Andrew W.; Symms, Mark R.; Koepp, Matthias J.

2013-01-01

Anterior temporal lobe resection controls seizures in 50–60% of patients with intractable temporal lobe epilepsy but may impair memory function, typically verbal memory following left, and visual memory following right anterior temporal lobe resection. Functional reorganization can occur within the ipsilateral and contralateral hemispheres. We investigated the reorganization of memory function in patients with temporal lobe epilepsy before and after left or right anterior temporal lobe resection and the efficiency of postoperative memory networks. We studied 46 patients with unilateral medial temporal lobe epilepsy (25/26 left hippocampal sclerosis, 16/20 right hippocampal sclerosis) before and after anterior temporal lobe resection on a 3 T General Electric magnetic resonance imaging scanner. All subjects had neuropsychological testing and performed a functional magnetic resonance imaging memory encoding paradigm for words, pictures and faces, testing verbal and visual memory in a single scanning session, preoperatively and again 4 months after surgery. Event-related analysis revealed that patients with left temporal lobe epilepsy had greater activation in the left posterior medial temporal lobe when successfully encoding words postoperatively than preoperatively. Greater pre- than postoperative activation in the ipsilateral posterior medial temporal lobe for encoding words correlated with better verbal memory outcome after left anterior temporal lobe resection. In contrast, greater postoperative than preoperative activation in the ipsilateral posterior medial temporal lobe correlated with worse postoperative verbal memory performance. These postoperative effects were not observed for visual memory function after right anterior temporal lobe resection. Our findings provide evidence for effective preoperative reorganization of verbal memory function to the ipsilateral posterior medial temporal lobe due to the underlying disease, suggesting that it is the capacity of the posterior remnant of the ipsilateral hippocampus rather than the functional reserve of the contralateral hippocampus that is important for maintaining verbal memory function after anterior temporal lobe resection. Early postoperative reorganization to ipsilateral posterior or contralateral medial temporal lobe structures does not underpin better performance. Additionally our results suggest that visual memory function in right temporal lobe epilepsy is affected differently by right anterior temporal lobe resection than verbal memory in left temporal lobe epilepsy. PMID:23715092

Processing Stages Underlying Word Recognition in the Anteroventral Temporal Lobe

PubMed Central

Halgren, Eric; Wang, Chunmao; Schomer, Donald L.; Knake, Susanne; Marinkovic, Ksenija; Wu, Julian; Ulbert, Istvan

2006-01-01

The anteroventral temporal lobe integrates visual, lexical, semantic and mnestic aspects of word-processing, through its reciprocal connections with the ventral visual stream, language areas, and the hippocampal formation. We used linear microelectrode arrays to probe population synaptic currents and neuronal firing in different cortical layers of the anteroventral temporal lobe, during semantic judgments with implicit priming, and overt word recognition. Since different extrinsic and associative inputs preferentially target different cortical layers, this method can help reveal the sequence and nature of local processing stages at a higher resolution than was previously possible. The initial response in inferotemporal and perirhinal cortices is a brief current sink beginning at ~120ms, and peaking at ~170ms. Localization of this initial sink to middle layers suggests that it represents feedforward input from lower visual areas, and simultaneously increased firing implies that it represents excitatory synaptic currents. Until ~800ms, the main focus of transmembrane current sinks alternates between middle and superficial layers, with the superficial focus becoming increasingly dominant after ~550ms. Since superficial layers are the target of local and feedback associative inputs, this suggests an alternation in predominant synaptic input between feedforward and feedback modes. Word repetition does not affect the initial perirhinal and inferotemporal middle layer sink, but does decrease later activity. Entorhinal activity begins later (~200ms), with greater apparent excitatory postsynaptic currents and multiunit activity in neocortically-projecting than hippocampal-projecting layers. In contrast to perirhinal and entorhinal responses, entorhinal responses are larger to repeated words during memory retrieval. These results identify a sequence of physiological activation, beginning with a sharp activation from lower level visual areas carrying specific information to middle layers. This is followed by feedback and associative interactions involving upper cortical layers, which are abbreviated to repeated words. Following bottom-up and associative stages, top-down recollective processes may be driven by entorhinal cortex. Word processing involves a systematic sequence of fast feedforward information transfer from visual areas to anteroventral temporal cortex, followed by prolonged interactions of this feedforward information with local associations, and feedback mnestic information from the medial temporal lobe. PMID:16488158

The Pliocene-Quaternary tectonic evolution of the Cilicia and Adana basins, eastern Mediterranean: Special reference to the development of the Kozan Fault zone

NASA Astrophysics Data System (ADS)

Aksu, A. E.; Walsh-Kennedy, S.; Hall, J.; Hiscott, R. N.; Yaltırak, C.; Akhun, S. D.; Çifçi, G.

2014-05-01

A grid of high-resolution multi-channel seismic reflection profiles allows the detailed mapping of the Kozan Fault zone in the Cilicia and Adana basins. The zone is delineated by an arcuate zone consisting of several ENE-WSW and NNE-SSW striking, closely-spaced high-angle extensional faults which define an ~ 300 km long and 15-20 km-wide “lazy-S” shaped structure along the southeastern fringes of the Taurus Mountain and along the northwestern margins of the Cilicia and Adana basins. In the Cilicia Basin the zone consists of several high-angle faults which exhibit small dip separations on the M-reflector and have tip points situated mainly in the lower and middle portion of the Pliocene-Quaternary succession. In the Adana Basin a family of northeast-striking and southeast dipping extensional faults occurs along the western and northwestern margin of the basin. The faults cut down with relatively steep dip into the ~ 700 ms thick Tortonian and older Miocene successions. Multi-channel seismic reflection profiles show that three prominent seismic markers divide the uppermost Messinian-Recent successions in the Cilicia and Adana basins into three subunits: the uppermost Messinian-Lower Pliocene subunit 1C between the M- and A-reflectors, the Upper Pliocene subunit 1B between the A- and P-reflectors and the Quaternary subunit 1A between the P-reflector and the seafloor. Prominent delta lobes are identified in the seismic profiles that are correlated with the ancestral Göksu River. Isopach maps constructed using depth-converted seismic reflection profiles show clear temporal and spatial variations of the delta lobes of the Göksu River during the latest Messinian-Recent. The uppermost Messinian-Lower Pliocene delta lobe is situated furthest to the northeast whereas the youngest Quaternary lobe is situated furthest to the southwest, with 20-35 km displacement along a northeast-southwest line, which suggests a conservative estimate of 0.43-0.75 cm/yr sinistral slip for the Kozan Fault zone.

Interaction of sea water and lava during submarine eruptions at mid-ocean ridges

USGS Publications Warehouse

Perfit, M.R.; Cann, J.R.; Fornari, D.J.; Engels, J.; Smith, D.K.; Ridley, W.I.; Edwards, M.H.

2003-01-01

Lava erupts into cold sea water on the ocean floor at mid-ocean ridges (at depths of 2,500 m and greater), and the resulting flows make up the upper part of the global oceanic crust. Interactions between heated sea water and molten basaltic lava could exert significant control on the dynamics of lava flows and on their chemistry. But it has been thought that heating sea water at pressures of several hundred bars cannot produce significant amounts of vapour and that a thick crust of chilled glass on the exterior of lava flows minimizes the interaction of lava with sea water. Here we present evidence to the contrary, and show that bubbles of vaporized sea water often rise through the base of lava flows and collect beneath the chilled upper crust. These bubbles of steam at magmatic temperatures may interact both chemically and physically with flowing lava, which could influence our understanding of deep-sea volcanic processes and oceanic crustal construction more generally. We infer that vapour formation plays an important role in creating the collapse features that characterize much of the upper oceanic crust and may accordingly contribute to the measured low seismic velocities in this layer.

Constraining the sedimentology and stratigraphy of submarine intraslope lobe deposits using exhumed examples from the Karoo Basin, South Africa

NASA Astrophysics Data System (ADS)

Spychala, Y. T.; Hodgson, D. M.; Flint, S. S.; Mountney, N. P.

2015-06-01

Intraslope lobe deposits provide a process record of the infill of accommodation on submarine slopes and their recognition enables the accurate reconstruction of the stratigraphic evolution of submarine slope systems. Extensive exposures of discrete sand-prone packages in Units D/E and E, Fort Brown Formation, Karoo Basin, South Africa, permit analysis of the sedimentology and stacking patterns of three intraslope lobe complexes and their palaeogeographic reconstruction via bed-scale analysis and physical correlation of key stratal surfaces. The sand-prone packages comprise tabular, aggradationally to slightly compensationally stacked lobe deposits with constituent facies associations that can be attributed to lobe axis, lobe off-axis, lobe-fringe and distal lobe-fringe environments. Locally, intraslope lobe deposits are incised by low aspect ratio channels that mark basinward progradation of the deepwater system. The origin of accommodation on the slope for lobe deposition is interpreted to be due to differential compaction or healing of scars from mass wasting processes. The stacking patterns and sedimentary facies arrangement identified in this study are distinct from those of more commonly recognized basin-floor lobe deposits, thereby enabling the establishment of recognition criteria for intraslope lobe deposits in other less well exposed and studied fine-grained systems. Compared to basin floor lobes, intraslope lobes are smaller in volume, influenced by higher degrees of confinement, and tend to show aggradational stacking patterns.

[Upper airway morphology in Down Syndrome patients under dexmedetomidine sedation].

PubMed

Subramanyam, Rajeev; Fleck, Robert; McAuliffe, John; Radhakrishnan, Rupa; Jung, Dorothy; Patino, Mario; Mahmoud, Mohamed

2016-01-01

Children with Down Syndrome are vulnerable to significant upper airway obstruction due to relative macroglossia and dynamic airway collapse. The objective of this study was to compare the upper airway dimensions of children with Down Syndrome and obstructive sleep apnea with normal airway under dexmedetomidine sedation. IRB approval was obtained. In this retrospective study, clinically indicated dynamic sagittal midline magnetic resonance images of the upper airway were obtained under low (1mcg/kg/h) and high (3mcg/kg/h) dose dexmedetomidine. Airway anteroposterior diameters and sectional areas were measured as minimum and maximum dimensions by two independent observers at soft palate (nasopharyngeal airway) and at base of the tongue (retroglossal airway). Minimum anteroposterior diameter and minimum sectional area at nasopharynx and retroglossal airway were significantly reduced in Down Syndrome compared to normal airway at both low and high dose dexmedetomidine. However, there were no significant differences between low and high dose dexmedetomidine in both Down Syndrome and normal airway. The mean apnea hypopnea index in Down Syndrome was 16±11. Under dexmedetomidine sedation, children with Down Syndrome and obstructive sleep apnea when compared to normal airway children show significant reductions in airway dimensions most pronounced at the narrowest points in the nasopharyngeal and retroglossal airways. Copyright © 2015 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

Upper airway morphology in Down Syndrome patients under dexmedetomidine sedation.

PubMed

Subramanyam, Rajeev; Fleck, Robert; McAuliffe, John; Radhakrishnan, Rupa; Jung, Dorothy; Patino, Mario; Mahmoud, Mohamed

2016-01-01

Children with Down Syndrome are vulnerable to significant upper airway obstruction due to relative macroglossia and dynamic airway collapse. The objective of this study was to compare the upper airway dimensions of children with Down Syndrome and obstructive sleep apnea with normal airway under dexmedetomidine sedation. IRB approval was obtained. In this retrospective study, clinically indicated dynamic sagittal midline magnetic resonance images of the upper airway were obtained under low (1mcg/kg/h) and high (3mcg/kg/h) dose dexmedetomidine. Airway anteroposterior diameters and sectional areas were measured as minimum and maximum dimensions by two independent observers at soft palate (nasopharyngeal airway) and at base of the tongue (retroglossal airway). Minimum anteroposterior diameter and minimum sectional area at nasopharynx and retroglossal airway were significantly reduced in Down Syndrome compared to normal airway at both low and high dose dexmedetomidine. However, there were no significant differences between low and high dose dexmedetomidine in both Down Syndrome and normal airway. The mean apnea hypopnea index in Down Syndrome was 16±11. Under dexmedetomidine sedation, children with Down Syndrome and obstructive sleep apnea when compared to normal airway children show significant reductions in airway dimensions most pronounced at the narrowest points in the nasopharyngeal and retroglossal airways. Copyright © 2015 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

Are the dimensions of submarine lobe systems independent of allogenic factors?

NASA Astrophysics Data System (ADS)

Prélat, A.; Covault, J. A.; Hodgson, D. M.; Fildani, A.; Flint, S. S.

2010-05-01

Submarine lobe dimensions from six different systems are compared: 1) the exhumed Permian Fan 3 lobe complex of the Tanqua Karoo, South Africa; 2) the modern Amazon fan channel-mouth lobe complex, offshore Brazil; 3) a portion of the modern distal Zaïre fan, offshore Angola / Congo; 4) a Pleistocene fan of the Kutai Basin, subsurface offshore Indonesia; 5) the modern Golo system, offshore east Corsica, France; and 6) a lobe complex deposited in the shallow subsurface, offshore Nigeria. These six systems have significantly different source-to-sink configurations (shelf dimension and slope topography), sediment supply characteristics (calibre and rate), tectonic settings, (palaeo) latitude, and delivery systems. Despite these differences, the lobe deposits share similar geometric and dimensional characteristics. Lobes are grouped into two distinct populations of geometries that can be related to basin-floor topography. The first population corresponds to areally extensive but thin lobes (average width 14 km × length 35 km × thickness 12 m) that were deposited onto low relief basin floor areas, like the Tanqua Karoo, the Amazon and the Zaïre systems. The second population corresponds to areally smaller but thicker lobes (average width 5 km × length 8 km × thickness 30 m) that were deposited into settings with higher amplitude of relief, like in the Corsican trough, the Kutai basin, and offshore Nigeria. Basin floor topography confining the lobes can be very subtle, and only occur on one side of the system. The two populations of lobe types, however, share similar volumes, in the order of 1 or 2 km3. The largest lobes are observed in the Zaïre fan, where the average lobe volume reaches 3.3 km3 and the smallest lobes are observed in the Corsican trough where the average lobe volume is 0.4 km3. This variation in lobe volume is minor when compared to the variation observed in present-day up-dip drainage systems, which provide sediment to the deep-water depositional systems and their lobes. This suggests that there is a limit to the total volume of sediment that individual lobes can reach before they shift to a new locus of deposition. In otherwords, big systems do not build big lobes, rather more lobes per unit time. Indeed, in the Amazon and the Zaïre systems, lobe life span is estimated to be 600 and 1450 years, respectively, whereas in the Corsican Golo system, lobe life span is ~ 10 times longer, around 10 to 14 × 103 years. A fundamental control on lobe volume is the propensity for flows to find the lowest topography. We postulate that a fundamental control on all distributive systems is the ratio of lobe thickness to feeder channel depth. The surface gradient from the feeder channel base and lobe top will tend to reduce through time as a lobe builds. This is not sustainable, and when a steeper lateral gradient is present a new depositional low will be used for flows to fill.

Morphology, structure, composition and build-up processes of the active channel-mouth lobe complex of the Congo deep-sea fan with inputs from remotely operated underwater vehicle (ROV) multibeam and video surveys

NASA Astrophysics Data System (ADS)

Dennielou, Bernard; Droz, Laurence; Babonneau, Nathalie; Jacq, Céline; Bonnel, Cédric; Picot, Marie; Le Saout, Morgane; Saout, Yohan; Bez, Martine; Savoye, Bruno; Olu, Karine; Rabouille, Christophe

2017-08-01

The detailed structure and composition of turbiditic channel-mouth lobes is still largely unknown because they commonly lie at abyssal water depths, are very thin and are therefore beyond the resolution of hull-mound acoustic tools. The morphology, structure and composition of the Congo turbiditic channel-mouth lobe complex (90×40 km; 2525 km2) were investigated with hull-mounted swath bathymetry, air gun seismics, 3.5 kHz sub-bottom profiler, sediment piston cores and also with high-resolution multibeam bathymetry and video acquired with a Remote Operating Vehicle (ROV). The lobe complex lies 760 km off the Congo River mouth in the Angola abyssal plain between 4740 and 5030 m deep. It is active and is fed by turbidity currents that deposit several centimetres of sediment per century. The lobe complex is subdivided into five lobes that have prograded. The lobes are dominantly muddy. Sand represents ca. 13% of the deposits and is restricted to the feeding channel and distributaries. The overall lobe body is composed of thin muddy to silty turbidites. The whole lobe complex is characterized by in situ mass wasting (slumps, debrites). The 1-m-resolution bathymetry shows pervasive slidings and block avalanches on the edges of the feeding channel and the channel mouth indicating that sliding occurs early and continuously in the lobe build-up. Mass wasting is interpreted as a consequence of very-high accumulation rates, over-steepening and erosion along the channels and is therefore an intrinsic process of lobe building. The bifurcation of feeding channels is probably triggered when the gradient in the distributaries at the top of a lobe becomes flat and when turbidity currents find their way on the higher gradient on the lobe side. It may also be triggered by mass wasting on the lobe side. When a new lobe develops, the abandoned lobes continue to collect significant turbiditic deposits from the feeding channel spillover, so that the whole lobe complex remains active. A conceptual lithostratigraphic model is proposed for five morpho-sedimentary environments: lobe rims, lobe body, distributaries, levees, feeding channel. This study shows that high-resolution bathymetry ROV observations are necessary to fully understand the build-up processes of modern channel-mouth lobes.

Endoscopic Bronchial Occlusion with Silicon Spigots for the Treatment of an Alveolar-pleural Fistula during Anti-tuberculosis Therapy for Tuberculous Empyema.

PubMed

Nishihara, Takashi; Hayama, Manabu; Okamoto, Norio; Tanaka, Ayako; Nishida, Takuji; Shiroyama, Takayuki; Tamiya, Motohiro; Morishita, Naoko; Suzuki, Hidekazu; Matsuoka, Hiroto; Hirashima, Tomonori

2016-01-01

A prolonged air leak caused by pulmonary tuberculosis is difficult to treat, and little is known about optimal treatment strategies. We herein report the case of a 60-year-old man who demonstrated tuberculous empyema with a fistula. An air leak from a tuberculous cavity in his left upper lobe persisted for approximately 4 months; surgical repair could not be performed due to a poor physical status and undernourishment. However, the air leak was successfully treated with endobronchial occlusion using two silicone spigots in left B3b and B4, without any adverse effects or aggravation of the infection.

[Pulmonary oxalosis with necrotizing pulmonary aspergillosis].

PubMed

Khabir, Abdelmajid; Makni, Salwa; Ayadi, Lobna; Boudawara, Tahia; Frikha, Imed; Sahnoun, Youssef; Jlidi, Rachid

2002-04-01

Pulmonary oxalosis is a very rare pseudotumoral lesion; it is often secondary to an aspergillus infection. Oxalic acid (C(2)H(2)O(4)) is a mycotoxin released by Aspergillus niger and sometimes by several other fungi, including A flavus and A fumigatus. We report a case of a 69 year old man, with previous history of pulmonary tuberculosis, followed for recurrent hemoptysis. On the chest radiography, the right upper lobe lung showed a cavitary lesion with thick and irregular walls and a dense material that suggested a pulmonary aspergilloma. Microscopically, it was a pulmonary oxalosis associated with chronic necrotising pulmonary aspergillosis. Our aim is to discuss the epidemiological characteristics, the diagnosis and the histogenesis of this unusual lesion.

[Pulmonary Carcinosarcoma Presenting Hemothorax Caused by Pleural Invasion;Report of a Case].

PubMed

Kazawa, Nobukata; Shibamoto, Yuta; Kitabayashi, Yukiya; Ishihara, Yumi; Gotoh, Taeko; Sawada, Yuusuke; Inukai, Ryo; Tsujimura, Takashi; Hattori, Hideo; Niimi, Akio; Nakanishi, Ryoichi; Kitaichi, Masanori

2016-11-01

A 71-year-old man presented with hemothorax with cough, sputa and worsening dyspnea. On chest X-ray and computed tomography(CT), a huge tumor in the right upper lobe with hematoma and small amount of gas suggesting hemopneumothorax was revealed. No apparent lymphadenopathy nor intrapulmonary metastases were observed. The tumor showed a little enhancement on the contrastenhanced CT. Then the resction of the tumor was performed, and the pathological evaluation revealed a carcionosarcoma (adenocarcinoma+osteosarcoma) pT3N0 (stage II B) G4 pl2. Sarcomatoid carcinoma such as carcinosarcoma should be considered as a possible cause of hemothorax in making a diagnosis of hemorrhagic hypovascular huge lung tumor.

Bilateral pulmonary infiltrates in association with disseminated actinomycosis.

PubMed

Dontfraid, F; Ramphal, R

1994-07-01

The most common infectious cause of bilateral upper-lobe pulmonary disease is tuberculosis. However, we recently encountered a patient with bilateral apical infiltrates and multiple soft-tissue abscesses caused by Actinomyces odontolyticus. Other findings included fever, weight loss, and leukocytosis, and the patient's only known source of immunosuppression was a long history of alcoholism. There was no history of diabetes, steroid use, or other chronic underlying disease. The diagnosis was made by culture of drainage fluid from one abscess. Therapy with intravenous penicillin G led to rapid clinical improvement and reduction in the infiltrates. To our knowledge, the presentation of pulmonary infection, with bilateral apical infiltrates due to A. odontolyticus has not been previously reported in the medical literature.

A Community-acquired Lung Abscess Attributable to Streptococcus pneumoniae which Extended Directly into the Chest Wall

PubMed Central

Ko, Yuki; Tobino, Kazunori; Yasuda, Yuichiro; Sueyasu, Takuto; Nishizawa, Saori; Yoshimine, Kouhei; Munechika, Miyuki; Asaji, Mina; Yamaji, Yoshikazu; Tsuruno, Kosuke; Miyajima, Hiroyuki; Mukasa, Yosuke; Ebi, Noriyuki

2017-01-01

We herein report the case of 75-year-old Japanese female with a community-acquired lung abscess attributable to Streptococcus pneumoniae (S. penumoniae) which extended into the chest wall. The patient was admitted to our hospital with a painful mass on the left anterior chest wall. A contrast-enhanced chest computed tomography scan showed a lung abscess in the left upper lobe which extended into the chest wall. Surgical debridement of the chest wall abscess and percutaneous transthoracic tube drainage of the lung abscess were performed. A culture of the drainage specimen yielded S. pneumoniae. The patient showed a remarkable improvement after the initiation of intravenous antibiotic therapy. PMID:28049987

A Community-acquired Lung Abscess Attributable to Streptococcus pneumoniae which Extended Directly into the Chest Wall.

PubMed

Ko, Yuki; Tobino, Kazunori; Yasuda, Yuichiro; Sueyasu, Takuto; Nishizawa, Saori; Yoshimine, Kouhei; Munechika, Miyuki; Asaji, Mina; Yamaji, Yoshikazu; Tsuruno, Kosuke; Miyajima, Hiroyuki; Mukasa, Yosuke; Ebi, Noriyuki

We herein report the case of 75-year-old Japanese female with a community-acquired lung abscess attributable to Streptococcus pneumoniae (S. penumoniae) which extended into the chest wall. The patient was admitted to our hospital with a painful mass on the left anterior chest wall. A contrast-enhanced chest computed tomography scan showed a lung abscess in the left upper lobe which extended into the chest wall. Surgical debridement of the chest wall abscess and percutaneous transthoracic tube drainage of the lung abscess were performed. A culture of the drainage specimen yielded S. pneumoniae. The patient showed a remarkable improvement after the initiation of intravenous antibiotic therapy.

[Eosinophilic pleural effusion possibly induced by fibrin sealant].

PubMed

Kambayashi, Takatoyo; Suzuki, Takashi

2012-02-01

A 74-year-old man underwent right upper lobectomy for the lung cancer and bullectomy of right lower lobe. Fibrin sealant was used for sealing the excision line. The increase of the pleural effusion with increasing C-reactive protein( CRP) and eosinophilia was noted at the 17th day after the operation. The pleural effusion was transparent and yellowish colored suggesting transudatory liquid. The eosinophil in the pleural effusion was as high as 14%. The drainage of the pleural effusion was performed for 2 days resulting in disappearing the abnormal accumulation without any additional treatment. The cause of pleural effusion was supposed to be fibrin sealant by a positive result of the drug lymphocyte stimulation test.

Spontaneous hepatic rupture in pregnancy.

PubMed

Nelson, E W; Archibald, L; Albo, D

1977-12-01

Hepatic rupture as a late complication of toxemic pregnancy is a rare yet lethal condition requiring rapid recognition and surgical management. The clinical triad of toxemia, right upper quadrant pain, and sudden hypotension is the diagnostic hallmark of presentation. Most patients present near the time of delivery and are found to have subcapsular hematomas of the right hepatic lobe with free rupture into the peritoneal cavity and resultant exsanguinating hemorrhage. The association of toxemia and disseminated intravascular coagulation with secondary microembolic damage to the liver and other organs has been discussed. Basic surgical principles in the managment of hepatic subcapsular hematomas, and the prolonged postoperative course and frequent complications in these patients have been stressed.

Extraosseus uptake of F-18 fluoride in the primary malignancy and cerebral metastasis in a case of non-small-cell lung cancer.

PubMed

Li, Yuxin; Tafti, Bashir A; Shaba, Wisam; Berenji, Gholam R

2011-07-01

A 68-year-old man with history of heavy smoking was admitted for increasing falls during the past 4 weeks. Chest x-ray revealed a right upper lobe mass. Biopsy demonstrated poorly differentiated non-small-cell carcinoma. F-18 fluoride positron emission tomography/computer tomography (PET/CT) was performed to evaluate bone metastasis. Review of the sectional PET images demonstrated extraosseous fluoride uptake in the primary lung mass, as well as ring-shaped fluoride uptake in the cerebral metastatic lesion. Neither of these lesions demonstrated calcifications on CT images. The patient received radiation treatment of the brain metastasis after F-18 fluoride PET/CT study.

Kaguyak dome field and its Holocene caldera, Alaska Peninsula

USGS Publications Warehouse

Fierstein, J.; Hildreth, W.

2008-01-01

Kaguyak Caldera lies in a remote corner of Katmai National Park, 375??km SW of Anchorage, Alaska. The 2.5-by-3-km caldera collapsed ~ 5.8 ?? 0.2??ka (14C age) during emplacement of a radial apron of poorly pumiceous crystal-rich dacitic pyroclastic flows (61-67% SiO2). Proximal pumice-fall deposits are thin and sparsely preserved, but an oxidized coignimbrite ash is found as far as the Valley of Ten Thousand Smokes, 80??km southwest. Postcaldera events include filling the 150-m-deep caldera lake, emplacement of two intracaldera domes (61.5-64.5% SiO2), and phreatic ejection of lakefloor sediments onto the caldera rim. CO2 and H2S bubble up through the lake, weakly but widely. Geochemical analyses (n = 148), including pre-and post-caldera lavas (53-74% SiO2), define one of the lowest-K arc suites in Alaska. The precaldera edifice was not a stratocone but was, instead, nine contiguous but discrete clusters of lava domes, themselves stacks of rhyolite to basalt exogenous lobes and flows. Four extracaldera clusters are mid-to-late Pleistocene, but the other five are younger than 60??ka, were truncated by the collapse, and now make up the steep inner walls. The climactic ignimbrite was preceded by ~ 200??years by radial emplacement of a 100-m-thick sheet of block-rich glassy lava breccia (62-65.5% SiO2). Filling the notches between the truncated dome clusters, the breccia now makes up three segments of the steep caldera wall, which beheads gullies incised into the breccia deposit prior to caldera formation. They were probably shed by a large lava dome extruding where the lake is today.

The Silent Canyon caldera complex: a three-dimensional model based on drill-hole stratigraphy and gravity inversion

USGS Publications Warehouse

McKee, Edwin H.; Hildenbrand, Thomas G.; Anderson, Megan L.; Rowley, Peter D.; Sawyer, David A.

1999-01-01

The structural framework of Pahute Mesa, Nevada, is dominated by the Silent Canyon caldera complex, a buried, multiple collapse caldera complex. Using the boundary surface between low density Tertiary volcanogenic rocks and denser granitic and weakly metamorphosed sedimentary rocks (basement) as the outer fault surfaces for the modeled collapse caldera complex, it is postulated that the caldera complex collapsed on steeply- dipping arcuate faults two, possibly three, times following eruption of at least two major ash-flow tuffs. The caldera and most of its eruptive products are now deeply buried below the surface of Pahute Mesa. Relatively low-density rocks in the caldera complex produce one of the largest gravity lows in the western conterminous United States. Gravity modeling defines a steep sided, cup-shaped depression as much as 6,000 meters (19,800 feet) deep that is surrounded and floored by denser rocks. The steeply dipping surface located between the low-density basin fill and the higher density external rocks is considered to be the surface of the ring faults of the multiple calderas. Extrapolation of this surface upward to the outer, or topographic rim, of the Silent Canyon caldera complex defines the upper part of the caldera collapse structure. Rock units within and outside the Silent Canyon caldera complex are combined into seven hydrostratigraphic units based on their predominant hydrologic characteristics. The caldera structures and other faults on Pahute Mesa are used with the seven hydrostratigraphic units to make a three-dimensional geologic model of Pahute Mesa using the "EarthVision" (Dynamic Graphics, Inc.) modeling computer program. This method allows graphic representation of the geometry of the rocks and produces computer generated cross sections, isopach maps, and three-dimensional oriented diagrams. These products have been created to aid in visualizing and modeling the ground-water flow system beneath Pahute Mesa.

Paleontological interpretations of crater processes and infilling of synimpact sediments from the Chesapeake Bay impact structure

USGS Publications Warehouse

Self-Trail, Jean M.; Edwards, Lucy E.; Litwin, Ronald J.

2009-01-01

Biostratigraphic analysis of sedimentary breccias and diamictons in the Chesapeake Bay impact structure provides information regarding the timing and processes of late-stage gravitational crater collapse and ocean resurge. Studies of calcareous nannofossil and palynomorph assemblages in the International Continental Scientific Drilling Program (ICDP)–U.S. Geological Survey (USGS) Eyreville A and B cores show the mixed-age, mixed-preservation microfossil assemblages that are typical of deposits from the upper part of the Chesapeake Bay impact structure. Sparse, poorly preserved, possibly thermally altered pollen is present within a gravelly sand interval below the granite slab at 1392 m in Eyreville core B, an interval that is otherwise barren of calcareous nannofossils and dinocysts. Gravitational collapse of water- saturated sediments from the transient crater wall resulted in the deposition of sediment clasts primarily derived from the nonmarine Cretaceous Potomac Formation. Collapse occurred before the arrival of resurge. Low pollen Thermal Alteration Index (TAI) values suggest that these sediments were not thermally altered by contact with the melt sheet. The arrival of resurge sedimentation is identified based on the presence of diamicton zones and stringers rich in glauconite and marine microfossils at 866.7 m. This horizon can be traced across the crater and can be used to identify gravitational collapse versus ocean-resurge sedimentation. Glauconitic quartz sand diamicton dominates the sediments above 618.2 m. Calcareous nannofossil and dino-flagellate data from this interval suggest that the earliest arriving resurge from the west contained little or no Cretaceous marine input, but later resurge pulses mined Cretaceous sediments east of the Watkins core in the annular trough. Additionally, the increased distance traveled by resurge to the central crater in turbulent flow conditions resulted in the disaggregation of Paleogene unconsolidated sediments. As a result, intact Paleogene clasts in Eyreville cores are rare, but clasts of semilithified Potomac Formation silts and clays are common.

Paleontological interpretations of crater processes and infilling of synimpact sediments from the Chesapeake Bay impact structure

USGS Publications Warehouse

,; Edwards, L.E.; Litwin, R.J.

2009-01-01

Biostratigraphic analysis of sedimentary breccias and diamictons in the Chesapeake Bay impact structure provides information regarding the timing and processes of late-stage gravitational crater collapse and ocean resurge. Studies of calcareous nannofossil and palynomorph assemblages in the International Continental Scientific Drilling Program (ICDP)-U.S. Geological Survey (USGS) Eyreville A and B cores show the mixed-age, mixed-preservation microfossil assemblages that are typical of deposits from the upper part of the Chesapeake Bay impact structure. Sparse, poorly preserved, possibly thermally altered pollen is present within a gravelly sand interval below the granite slab at 1392 m in Eyreville core B, an interval that is otherwise barren of calcareous nannofossils and dinocysts. Gravitational collapse of watersaturated sediments from the transient crater wall resulted in the deposition of sediment clasts primarily derived from the nonmarine Cretaceous Potomac Formation. Collapse occurred before the arrival of resurge. Low pollen Thermal Alteration Index (TAI) values suggest that these sediments were not thermally altered by contact with the melt sheet. The arrival of resurge sedimentation is identified based on the presence of diamicton zones and stringers rich in glauconite and marine microfossils at 866.7 m. This horizon can be traced across the crater and can be used to identify gravitational collapse versus ocean-resurge sedimentation. Glauconitic quartz sand diamicton dominates the sediments above 618.2 m. Calcareous nannofossil and dinoflagellate data from this interval suggest that the earliest arriving resurge from the west contained little or no Cretaceous marine input, but later resurge pulses mined Cretaceous sediments east of the Watkins core in the annular trough. Additionally, the increased distance traveled by resurge to the central crater in turbulent flow conditions resulted in the disaggregation of Paleogene unconsolidated sediments. As a result, intact Paleogene clasts in Eyreville cores are rare, but clasts of semilithified Potomac Formation silts and clays are common. ?? 2009 The Geological Society of America.

An Integrative Approach for Defining Plinian and Sub-Plinian Eruptive Scenarios at Andesitic Volcanoes: Event-Lithostratigraphy, Eruptive Parameters and Pyroclast Textural Variations of the Largest Late-Holocene Eruptions of Mt. Taranaki, New Zealand.

NASA Astrophysics Data System (ADS)

Torres-Orozco, R.; Cronin, S. J.; Damaschke, M.; Kosik, S.; Pardo, N.

2016-12-01

Three eruptive scenarios were determined based on the event-lithostratigraphic reconstruction of the largest late-Holocene eruptions of the andesitic Mt. Taranaki, New Zealand: a) sustained dome-effusion followed by sudden stepwise collapse and unroofing of gas-rich magma; b) repeated plug and burst events generated by transient open-/closed-vent conditions; and c) open-vent conditions of more mafic magmas erupting from a satellite vent. Pyroclastic density currents (PDCs) are the most frequent outcome in every scenario. They can be produced in any/every eruption phase by formation and either repetitive-partial or total gravity-driven collapse of lava domes in the summit crater (block-and-ash flows), frequently followed by sudden magma decompression and violent, highly unsteady to quasi-steady lateral expansion (blast-like PDCs); by collapse or single-pulse fall-back of unsteady eruption columns (pyroclastic flow- and surge-type currents); or during highly unsteady and explosive hydromagmatic phases (wet surges). Fall deposits are produced during the climatic phase of each eruptive scenario by the emplacement of (i) high, sustained and steady, (ii) sustained and height-oscillating, (iii) quasi-steady and pulsating, or (iv) unsteady and totally collapsing eruption columns. Volumes, column heights and mass- and volume-eruption rates indicate that these scenarios correspond to VEI 4-5 plinian and sub-plinian multi-phase and style-shifting episodes, similar or larger than the most recent 1655 AD activity, and comparable to plinian eruptions of e.g. Apoyeque, Colima, Merapi and Tarawera volcanoes. Whole-rock chemistry, textural reconstructions and density-porosity determinations suggest that the different eruptive scenarios are mainly driven by variations in the density structure of magma in the upper conduit. Assuming a simple single conduit model, the style transitions can be explained by differing proportions of alternating gas-poor/degassed and gas-rich magma.