The immediate upstream region of the 5′-UTR from the AUG start codon has a pronounced effect on the translational efficiency in Arabidopsis thaliana

PubMed Central

Kim, Younghyun; Lee, Goeun; Jeon, Eunhyun; Sohn, Eun ju; Lee, Yongjik; Kang, Hyangju; Lee, Dong wook; Kim, Dae Heon; Hwang, Inhwan

2014-01-01

The nucleotide sequence around the translational initiation site is an important cis-acting element for post-transcriptional regulation. However, it has not been fully understood how the sequence context at the 5′-untranslated region (5′-UTR) affects the translational efficiency of individual mRNAs. In this study, we provide evidence that the 5′-UTRs of Arabidopsis genes showing a great difference in the nucleotide sequence vary greatly in translational efficiency with more than a 200-fold difference. Of the four types of nucleotides, the A residue was the most favourable nucleotide from positions −1 to −21 of the 5′-UTRs in Arabidopsis genes. In particular, the A residue in the 5′-UTR from positions −1 to −5 was required for a high-level translational efficiency. In contrast, the T residue in the 5′-UTR from positions −1 to −5 was the least favourable nucleotide in translational efficiency. Furthermore, the effect of the sequence context in the −1 to −21 region of the 5′-UTR was conserved in different plant species. Based on these observations, we propose that the sequence context immediately upstream of the AUG initiation codon plays a crucial role in determining the translational efficiency of plant genes. PMID:24084084

51F earth observations

NASA Image and Video Library

2009-06-25

51F-42-058 (29 July-6 Aug 1985) --- This excellent view covers portions of Switzerland, France, and Italy. Lac Leman (Lake of Geneva) is at the center. The valley of the Rhone River can be seen from Tyon (lower left edge) upstream to the Swiss town of Brig. Great Alpine peaks including Mount Blanc, Matterhorn, Monte Rosa,Jungfrau, and Finsteraarhorn can be seen. Famous resorts in the photo include Aosta, Chamonix, Monreux, Laussane, Gstaad, Interlaken, Stresa, and Zermatt. The Swiss capital of Bern is at the upper right.

Translation of the first upstream ORF in the hepatitis B virus pregenomic RNA modulates translation at the core and polymerase initiation codons

PubMed Central

Chen, Augustine; Kao, Y. F.; Brown, Chris M.

2005-01-01

The human hepatitis B virus (HBV) has a compact genome encoding four major overlapping coding regions: the core, polymerase, surface and X. The polymerase initiation codon is preceded by the partially overlapping core and four or more upstream initiation codons. There is evidence that several mechanisms are used to enable the synthesis of the polymerase protein, including leaky scanning and ribosome reinitiation. We have examined the first AUG in the pregenomic RNA, it precedes that of the core. It initiates an uncharacterized short upstream open reading frame (uORF), highly conserved in all HBV subtypes, we designated the C0 ORF. This arrangement suggested that expression of the core and polymerase may be affected by this uORF. Initiation at the C0 ORF was confirmed in reporter constructs in transfected cells. The C0 ORF had an inhibitory role in downstream expression from the core initiation site in HepG2 cells and in vitro, but also stimulated reinitiation at the polymerase start when in an optimal context. Our results indicate that the C0 ORF is a determinant in balancing the synthesis of the core and polymerase proteins. PMID:15731337

Leaderless mRNAs are circularized in Chlamydomonas reinhardtii mitochondria.

PubMed

Cahoon, A Bruce; Qureshi, Ali A

2018-06-01

The mitochondrial genome of Chlamydomonas reinhardtii encodes eight protein coding genes transcribed on two polycistronic primary transcripts. The mRNAs are endonucleolytically cleaved from these transcripts directly upstream of their AUG start codons, creating leaderless mRNAs with 3' untranslated regions (UTR) comprised of most or all of their downstream intergenic regions. In this report, we provide evidence that these processed linear mRNAs are circularized, which places the 3' UTR upstream of the 5' start codon, creating a leader sequence ex post facto. The circular mRNAs were found to be ribosome associate by polysome profiling experiments suggesting they are translated. Sequencing of the 3'-5' junctions of the circularized mRNAs found the intra-molecular ligations occurred between fully processed 5' ends (the start AUG) and a variable 3' terminus. For five genes (cob, cox, nd2, nd4, and nd6), some of the 3' ends maintained an oligonucleotide addition during ligation, and for two of them, cob and nd6, these 3' termini were the most commonly recovered sequence. Previous reports have shown that after cleavage, three untemplated oligonucleotide additions may occur on the 3' termini of these mRNAs-adenylation, uridylylation, or cytidylation. These results suggest oligo(U) and oligo(C) additions may be part of the maturation process since they are maintained in the circular mRNAs. Circular RNAs occur in organisms across the biological spectrum, but their purpose in some systems, such as organelles (mitochondria and chloroplasts) is unclear. We hypothesize, that in C. reinhardtii mitochondria it may create a leader sequence to facilitate translation initiation, which may negate the need for an alternative translation initiation mechanism in this system, as previously speculated. In addition, circularization may play a protective role against exonucleases, and/or increase translational productivity.

Tissue specific expression of the retinoic acid receptor-beta 2: regulation by short open reading frames in the 5'-noncoding region

PubMed Central

1994-01-01

The 40-S subunit of eukaryotic ribosomes binds to the capped 5'-end of mRNA and scans for the first AUG in a favorable sequence context to initiate translation. Most eukaryotic mRNAs therefore have a short 5'- untranslated region (5'-UTR) and no AUGs upstream of the translational start site; features that seem to assure efficient translation. However, approximately 5-10% of all eukaryotic mRNAs, particularly those encoding for regulatory proteins, have complex leader sequences that seem to compromise translational initiation. The retinoic-acid- receptor-beta 2 (RAR beta 2) mRNA is such a transcript with a long (461 nucleotides) 5'-UTR that contains five, partially overlapping, upstream open reading frames (uORFs) that precede the major ORF. We have begun to investigate the function of this complex 5'-UTR in transgenic mice, by introducing mutations in the start/stop codons of the uORFs in RAR beta 2-lacZ reporter constructs. When we compared the expression patterns of mutant and wild-type constructs we found that these mutations affected expression of the downstream RAR beta 2-ORF, resulting in an altered regulation of RAR beta 2-lacZ expression in heart and brain. Other tissues were unaffected. RNA analysis of adult tissues demonstrated that the uORFs act at the level of translation; adult brains and hearts of transgenic mice carrying a construct with either the wild-type or a mutant UTR, had the same levels of mRNA, but only the mutant produced protein. Our study outlines an unexpected role for uORFs: control of tissue-specific and developmentally regulated gene expression. PMID:7962071

Translational efficiency of poliovirus mRNA: mapping inhibitory cis-acting elements within the 5' noncoding region.

PubMed Central

Pelletier, J; Kaplan, G; Racaniello, V R; Sonenberg, N

1988-01-01

Poliovirus mRNA contains a long 5' noncoding region of about 750 nucleotides (the exact number varies among the three virus serotypes), which contains several AUG codons upstream of the major initiator AUG. Unlike most eucaryotic mRNAs, poliovirus does not contain a m7GpppX (where X is any nucleotide) cap structure at its 5' end and is translated by a cap-independent mechanism. To study the manner by which poliovirus mRNA is expressed, we examined the translational efficiencies of a series of deletion mutants within the 5' noncoding region of the mRNA. In this paper we report striking translation system-specific differences in the ability of the altered mRNAs to be translated. The results suggest the existence of an inhibitory cis-acting element(s) within the 5' noncoding region of poliovirus (between nucleotides 70 and 381) which restricts mRNA translation in reticulocyte lysate, wheat germ extract, and Xenopus oocytes, but not in HeLa cell extracts. In addition, we show that HeLa cell extracts contain a trans-acting factor(s) that overcomes this restriction. Images PMID:2836606

uORFs with unusual translational start codons autoregulate expression of eukaryotic ornithine decarboxylase homologs

PubMed Central

Ivanov, Ivaylo P.; Loughran, Gary; Atkins, John F.

2008-01-01

In a minority of eukaryotic mRNAs, a small functional upstream ORF (uORF), often performing a regulatory role, precedes the translation start site for the main product(s). Here, conserved uORFs in numerous ornithine decarboxylase homologs are identified from yeast to mammals. Most have noncanonical evolutionarily conserved start codons, the main one being AUU, which has not been known as an initiator for eukaryotic chromosomal genes. The AUG-less uORF present in mouse antizyme inhibitor, one of the ornithine decarboxylase homologs in mammals, mediates polyamine-induced repression of the downstream main ORF. This repression is part of an autoregulatory circuit, and one of its sensors is the AUU codon, which suggests that translation initiation codon identity is likely used for regulation in eukaryotes. PMID:18626014

An Upstream Open Reading Frame Is Essential for Feedback Regulation of Ascorbate Biosynthesis in Arabidopsis

PubMed Central

Laing, William A.; Martínez-Sánchez, Marcela; Wright, Michele A.; Bulley, Sean M.; Brewster, Di; Dare, Andrew P.; Rassam, Maysoon; Wang, Daisy; Storey, Roy; Macknight, Richard C.; Hellens, Roger P.

2015-01-01

Ascorbate (vitamin C) is an essential antioxidant and enzyme cofactor in both plants and animals. Ascorbate concentration is tightly regulated in plants, partly to respond to stress. Here, we demonstrate that ascorbate concentrations are determined via the posttranscriptional repression of GDP-l-galactose phosphorylase (GGP), a major control enzyme in the ascorbate biosynthesis pathway. This regulation requires a cis-acting upstream open reading frame (uORF) that represses the translation of the downstream GGP open reading frame under high ascorbate concentration. Disruption of this uORF stops the ascorbate feedback regulation of translation and results in increased ascorbate concentrations in leaves. The uORF is predicted to initiate at a noncanonical codon (ACG rather than AUG) and encode a 60- to 65-residue peptide. Analysis of ribosome protection data from Arabidopsis thaliana showed colocation of high levels of ribosomes with both the uORF and the main coding sequence of GGP. Together, our data indicate that the noncanonical uORF is translated and encodes a peptide that functions in the ascorbate inhibition of translation. This posttranslational regulation of ascorbate is likely an ancient mechanism of control as the uORF is conserved in GGP genes from mosses to angiosperms. PMID:25724639

An upstream open reading frame is essential for feedback regulation of ascorbate biosynthesis in Arabidopsis.

PubMed

Laing, William A; Martínez-Sánchez, Marcela; Wright, Michele A; Bulley, Sean M; Brewster, Di; Dare, Andrew P; Rassam, Maysoon; Wang, Daisy; Storey, Roy; Macknight, Richard C; Hellens, Roger P

2015-03-01

Ascorbate (vitamin C) is an essential antioxidant and enzyme cofactor in both plants and animals. Ascorbate concentration is tightly regulated in plants, partly to respond to stress. Here, we demonstrate that ascorbate concentrations are determined via the posttranscriptional repression of GDP-l-galactose phosphorylase (GGP), a major control enzyme in the ascorbate biosynthesis pathway. This regulation requires a cis-acting upstream open reading frame (uORF) that represses the translation of the downstream GGP open reading frame under high ascorbate concentration. Disruption of this uORF stops the ascorbate feedback regulation of translation and results in increased ascorbate concentrations in leaves. The uORF is predicted to initiate at a noncanonical codon (ACG rather than AUG) and encode a 60- to 65-residue peptide. Analysis of ribosome protection data from Arabidopsis thaliana showed colocation of high levels of ribosomes with both the uORF and the main coding sequence of GGP. Together, our data indicate that the noncanonical uORF is translated and encodes a peptide that functions in the ascorbate inhibition of translation. This posttranslational regulation of ascorbate is likely an ancient mechanism of control as the uORF is conserved in GGP genes from mosses to angiosperms. © 2015 American Society of Plant Biologists. All rights reserved.

The CUG-initiated larger form coat protein of Chinese wheat mosaic virus binds to the cysteine-rich RNA silencing suppressor.

PubMed

Sun, Liying; Andika, Ida Bagus; Shen, Jiangfeng; Yang, Di; Ratti, Claudio; Chen, Jianping

2013-10-01

Some viruses use alternative translation initiation at non-AUG codons as a strategy to produce multiple proteins during gene expression. Here we show that, using this strategy, Chinese wheat mosaic virus (CWMV; Furovirus) expresses a larger form of coat protein (N-ext/CP) in infected plants. Site-directed mutagenesis and transient expression analysis confirmed that CWMV N-ext/CP is initiated at an upstream in-frame CUG codon at nucleotide position 207-209 of RNA 2, which adds a 39 amino acid (aa) N-terminal extension to the major CP. Interestingly, in planta and in vitro analyses indicated that CWMV N-ext/CP but not CP interacts with the CWMV cysteine-rich protein (CRP), an RNA silencing suppressor. We further determined that the N-terminal 39 aa extension, particularly the 10 aa region immediately upstream of the major CP coding region is responsible for the interaction of N-ext/CP with CRP. In an Agrobacterium co-infiltration assay, co-expression with N-ext/CP did not affect CRP silencing suppression activity. Thus the alternative translation initiation at a CUG codon provides the CWMV N-ext/CP with the ability to bind to the viral silencing suppressor. Copyright © 2013 Elsevier B.V. All rights reserved.

Bioinformatic analysis suggests that the Orbivirus VP6 cistron encodes an overlapping gene

PubMed Central

Firth, Andrew E

2008-01-01

Background The genus Orbivirus includes several species that infect livestock – including Bluetongue virus (BTV) and African horse sickness virus (AHSV). These viruses have linear dsRNA genomes divided into ten segments, all of which have previously been assumed to be monocistronic. Results Bioinformatic evidence is presented for a short overlapping coding sequence (CDS) in the Orbivirus genome segment 9, overlapping the VP6 cistron in the +1 reading frame. In BTV, a 77–79 codon AUG-initiated open reading frame (hereafter ORFX) is present in all 48 segment 9 sequences analysed. The pattern of base variations across the 48-sequence alignment indicates that ORFX is subject to functional constraints at the amino acid level (even when the constraints due to coding in the overlapping VP6 reading frame are taken into account; MLOGD software). In fact the translated ORFX shows greater amino acid conservation than the overlapping region of VP6. The ORFX AUG codon has a strong Kozak context in all 48 sequences. Each has only one or two upstream AUG codons, always in the VP6 reading frame, and (with a single exception) always with weak or medium Kozak context. Thus, in BTV, ORFX may be translated via leaky scanning. A long (83–169 codon) ORF is present in a corresponding location and reading frame in all other Orbivirus species analysed except Saint Croix River virus (SCRV; the most divergent). Again, the pattern of base variations across sequence alignments indicates multiple coding in the VP6 and ORFX reading frames. Conclusion At ~9.5 kDa, the putative ORFX product in BTV is too small to appear on most published protein gels. Nonetheless, a review of past literature reveals a number of possible detections. We hope that presentation of this bioinformatic analysis will stimulate an attempt to experimentally verify the expression and functional role of ORFX, and hence lead to a greater understanding of the molecular biology of these important pathogens. PMID:18489030

Interagency Rebuilding Efforts in Iraq: A Case Study of the Rusafa Political District

DTIC Science & Technology

2013-02-26

Cart Seller 18-Aug-2010 $950.00 PRIVSEC NON-CON Cart Seller 18-Aug-2010 $500.00 PRIVSEC NON-CON Embroidery 18-Aug-2010 $22,900.00 PRIVSEC NON-CON...Kindergarten 18-Aug-2010 $11,300.00 PRIVSEC 50 NON-CON Embroidery & Sewing Factory 18-Aug-2010 $21,000.00 PRIVSEC NON-CON Book Shop 18-Aug-2010 $3,204.00

Impacts of a large array of offshore wind farms on precipitation during hurricane Harvey

NASA Astrophysics Data System (ADS)

Pan, Y.; Archer, C. L.

2017-12-01

Hurricane Harvey brought to the Texas coast possibly the heaviest rain ever recorded in U.S. history, which then caused flooding at unprecedented levels. Previous studies have shown that large arrays of offshore wind farms can extract kinetic energy from a hurricane and thus reduce the wind and storm surge. This study will quantitatively test weather the offshore turbines may also affect precipitation patterns. The Weather Research Forecast model is employed to model Harvey and the offshore wind farms are parameterized as elevated drag and turbulence kinetic energy sources. The turbines (7.8 MW Enercon-126 with rotor diameter D=127 m) are placed along the coast of Texas and Louisiana within 100 km from the shore, where the water depth is below 200 meters. Three spacing between turbines are considered (with the number of turbines in parenthesis): 7D×7D (149,936), 9D×9D (84,339), and 11D×11D (56,226). A fourth case (9D×9D) with a smaller area and thus less turbines (33,363) is added to the simulations to emphasize the impacts of offshore turbines installed specifically to protect the city of Houston, which was flooded heavily during hurricane Harvey. The model is integrated for 24 hours from 00UTC Aug 26th, 2017 to 00UTC Aug 27th, 2017. Model results indicate that the offshore wind farms have a strong impact on the distribution of 24-hour accumulated precipitation, with an obvious decrease onshore, downstream of the wind farms, and an increase in the offshore areas, upstream of or within the wind farms. A sector covering the metro-Houston area is chosen to study the sensitivity of the four different wind farm layouts. The spatial-average 24-hour accumulated precipitation is decreased by 37%, 28%, 20% and 25% respectively for the four cases. Compared with the control case with no wind turbines, increased horizontal wind divergence and lower vertical velocity are found where the precipitation is reduced onshore, whereas increased horizontal wind convergence and higher vertical velocity occur upstream or within the offshore wind farms. These preliminary results suggest that large arrays of offshore wind turbines can effectively protect the coast from heavy rain during hurricanes and that smart layouts with fewer turbines over smaller areas can be almost as effective as those with more turbines over larger areas.

Characterization of the Arabidopsis Augmin Complex Uncovers Its Critical Function in the Assembly of the Acentrosomal Spindle and Phragmoplast Microtubule Arrays[W

PubMed Central

Hotta, Takashi; Kong, Zhaosheng; Ho, Chin-Min Kimmy; Zeng, Cui Jing Tracy; Horio, Tetsuya; Fong, Sophia; Vuong, Trang; Lee, Yuh-Ru Julie; Liu, Bo

2012-01-01

Plant cells assemble the bipolar spindle and phragmoplast microtubule (MT) arrays in the absence of the centrosome structure. Our recent findings in Arabidopsis thaliana indicated that AUGMIN subunit3 (AUG3), a homolog of animal dim γ-tubulin 3, plays a critical role in γ-tubulin–dependent MT nucleation and amplification during mitosis. Here, we report the isolation of the entire plant augmin complex that contains eight subunits. Among them, AUG1 to AUG6 share low sequence similarity with their animal counterparts, but AUG7 and AUG8 share homology only with proteins of plant origin. Genetic analyses indicate that the AUG1, AUG2, AUG4, and AUG5 genes are essential, as stable mutations in these genes could only be transmitted to heterozygous plants. The sterile aug7-1 homozygous mutant in which AUG7 expression is significantly reduced exhibited pleiotropic phenotypes of seriously retarded vegetative and reproductive growth. The aug7-1 mutation caused delocalization of γ-tubulin in the mitotic spindle and phragmoplast. Consequently, spindles were abnormally elongated, and their poles failed to converge, as MTs were splayed to discrete positions rendering deformed arrays. In addition, the mutant phragmoplasts often had disorganized MT bundles with uneven edges. We conclude that assembly of MT arrays during plant mitosis depends on the augmin complex, which includes two plant-specific subunits. PMID:22505726

Cost Benefit Analysis (CBA) of Collocating and Combining the Commmunications School (MCB Quantico) with the Marine Corps Communications-Electronics School (MCCES) at 29 Palms, CA

DTIC Science & Technology

2011-05-06

Softball Team Softball Game Recreation 15 4-Aug 0600-0800 2.0 Platoon CFT Training Leadership 70 4-Aug 0700-0800 1.0 Platoon PME PFT Leadership...Ops 12 5-Aug 1430-1730 3.0 Platoon Field Day Leadership 70 5-Aug 1730-1930 2.0 Softball Team Softball Game Recreation 15 5-Aug 1930-2130 2.0... Softball Team Softball Game Recreation 15 5-Aug 1930-2130 2.0 Comm Scol Spouses Day Leadership Varies 6-Aug 0600-0800 2.0 Platoon PT Leadership 70 6

What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?

PubMed Central

Pöyry, Tuija A.A.; Kaminski, Ann; Jackson, Richard J.

2004-01-01

If the 5′-proximal AUG triplet in a mammalian mRNA is followed by a short open reading frame (sORF), a significant fraction of ribosomes resume scanning after termination of sORF translation, and reinitiate at a downstream AUG. To examine the underlying mechanism, we examined reinitiation in vitro using a series of mRNAs that differed only in the 5′-untranslated region (UTR). Efficient reinitiation was found to occur only if the eIF4F complex, or at a minimum the central one-third fragment of eIF4G, participated in the primary initiation event at the sORF initiation codon. It did not occur, however, when sORF translation was driven by the classical swine fever virus or cricket paralysis virus internal ribosome entry sites (IRESs), which do not use eIF4A, 4B, 4E, or 4G. A critical test was provided by an mRNA with an unstructured 5′-UTR, which is translated by scanning but does not absolutely need eIF4G and eIF4A: There was efficient reinitiation in a standard reticulocyte lysate, when initiation would be largely driven by eIF4F, but no reinitiation in an eIF4G-depleted lysate. These results suggest that resumption of scanning may depend on the interaction between eIF4F (or the eIF4G central domain) and the ribosome being maintained while the ribosome translates the sORF. PMID:14701882

40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

Code of Federal Regulations, 2012 CFR

2012-07-01

... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

Code of Federal Regulations, 2010 CFR

2010-07-01

... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

Code of Federal Regulations, 2014 CFR

2014-07-01

... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

Code of Federal Regulations, 2011 CFR

2011-07-01

... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

40 CFR Appendix Vii to Part 268 - LDR Effective Dates of Surface Disposed Prohibited Hazardous Wastes

Code of Federal Regulations, 2013 CFR

2013-07-01

... Dates of Surface Disposed Wastes (Non-Soil and Debris) Regulated in the LDRS a—Comprehensive List Waste... radioactive wastes June 30, 1994. F039 Wastewater Aug. 8, 1990. F039 Nonwastewater May 8, 1992. K001 (organics.... K085 All Aug. 8, 1990. K086 (organics) b All Aug. 8, 1988. K086 All others Aug. 8, 1988. K087 All Aug...

Non-AUG translation: a new start for protein synthesis in eukaryotes

PubMed Central

Kearse, Michael G.; Wilusz, Jeremy E.

2017-01-01

Although it was long thought that eukaryotic translation almost always initiates at an AUG start codon, recent advancements in ribosome footprint mapping have revealed that non-AUG start codons are used at an astonishing frequency. These non-AUG initiation events are not simply errors but instead are used to generate or regulate proteins with key cellular functions; for example, during development or stress. Misregulation of non-AUG initiation events contributes to multiple human diseases, including cancer and neurodegeneration, and modulation of non-AUG usage may represent a novel therapeutic strategy. It is thus becoming increasingly clear that start codon selection is regulated by many trans-acting initiation factors as well as sequence/structural elements within messenger RNAs and that non-AUG translation has a profound impact on cellular states. PMID:28982758

Splicing of goose parvovirus pre-mRNA influences cytoplasmic translation of the processed mRNA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Long; Pintel, David J., E-mail: pinteld@missouri.edu

2012-04-25

Translation of goose parvovirus (GPV) 72 kDa Rep 1 is initiated from unspliced P9-generated mRNAs in ORF1 from the first in-frame AUG (537 AUG); however, this AUG is bypassed in spliced P9-generated RNA: translation of the 52 kDa Rep 2 protein from spliced RNA is initiated in ORF2 at the next AUG downstream (650 AUG). Usage of the 537 AUG was restored in spliced RNA when the GPV intron was replaced with a chimeric SV40 intron, or following specific mutations of the GPV intron which did not appear in the final spliced mRNA. Additionally, 650 AUG usage was gained inmore » unspliced RNA when the GPV intron splice sites were debilitated. Splicing-dependent regulation of translation initiation was mediated in cis by GPV RNA surrounding the target AUGs. Thus, nuclear RNA processing of GPV P9-generated pre-mRNAs has a complex, but significant, effect on alternative translation initiation of the GPV Rep proteins.« less

Murine homeobox-containing gene, Msx-1: analysis of genomic organization, promoter structure, and potential autoregulatory cis-acting elements.

PubMed

Kuzuoka, M; Takahashi, T; Guron, C; Raghow, R

1994-05-01

Detailed molecular organization of the coding and upstream regulatory regions of the murine homeodomain-containing gene, Msx-1, is reported. The protein-encoding portion of the gene is contained in two exons, 590 and 1214 bp in length, separated by a 2107-bp intron; the homeodomain is located in the second exon. The two-exon organization of the murine Msx-1 gene resembles a number of other homeodomain-containing genes. The 5'-(GTAAGT) and 3'-(CCCTAG) splicing junctions and the mRNA polyadenylation signal (UAUAA) of the murine Msx-1 gene are also characteristic of other vertebrate genes. By nuclease protection and primer extension assays, the start of transcription of the Msx-1 gene was located 256 bp upstream of the first AUG. Computer analysis of the promoter proximal 1280-bp sequence revealed a number of potentially important cis-regulatory sequences; these include the recognition elements for Ap-1, Ap-2, Ap-3, Sp-1, a possible binding site for RAR:RXR, and a number of TCF-1 consensus motifs. Importantly, a perfect reverse complement of (C/G)TTAATTG, which was recently shown to be an optimal binding sequence for the homeodomain of Msx-1 protein (K.M. Catron, N. Iler, and C. Abate (1993) Mol. Cell. Biol. 13:2354-2365), was also located in the murine Msx-1 promoter. Binding of bacterially expressed Msx-1 homeodomain polypeptide to Msx-1-specific oligonucleotide was experimentally demonstrated, raising a distinct possibility of autoregulation of this developmentally regulated gene.

JPRS Report, East Europe.

DTIC Science & Technology

1990-10-01

of Persons Ransacked [TALLOZO 24 Aug] 20 Terrifying Billions [TALLOZO 24 Aug] 2 Dollar Vouchers With Question Marks [TALLOZO 24 Aug] 21...Aug] ■■■■■■■■■■■ 38 Price Guarantees Not Enough To Stabilize Food Market [ZIELONY SZTANDAR 22 Jul] 40 Farmers Subsidize Own Crops To Bring...34—first two paragraphs are MAGYAR NEMZET introduction] [Text] Several analytical statements and critical political advertisements appeared in the

Southeast Asia Report.

DTIC Science & Technology

1985-09-13

MAS Wins Contract to Service Air Force Planes (ANTARA NEWS BULLETIN, 3 Aug 85) Leaders Receive Messages of Thanks From MPR (KPL, 14 Aug 85...Dissolve Batasan ( BUSINESS DAY, 16 Aug 85) 31 Author on ’Quid-Pro-Quo’ in Sabah Claim (Nelly Sindayen; BULLETIN TODAY, 2 Jul 85) 32 Columnist...Exchange ( BUSINESS DAY, 16 Aug 85) 49 Batasan Speaker Yniguez ’Welcomed’ USSR Peace Efforts (Cross-reference) Bigornia Comments on USSR Aid to

Theoretical study of the XP3 (X = Al, B, Ga) clusters

NASA Astrophysics Data System (ADS)

Ueno, Leonardo T.; Lopes, Cinara; Malaspina, Thaciana; Roberto-Neto, Orlando; Canuto, Sylvio; Machado, Francisco B. C.

2012-05-01

The lowest singlet and triplet states of AlP3, GaP3 and BP3 molecules with Cs, C2v and C3v symmetries were characterized using the B3LYP functional and the aug-cc-pVTZ and aug-cc-pVQZ correlated consistent basis sets. Geometrical parameters and vibrational frequencies were calculated and compared to existent experimental and theoretical data. Relative energies were obtained with single point CCSD(T) calculations using the aug-cc-pVTZ, aug-cc-pVQZ and aug-cc-pV5Z basis sets, and then extrapolating to the complete basis set (CBS) limit.

Translations on Eastern Europe, Political, Sociological and Military Affairs, Number 1583

DTIC Science & Technology

1978-09-05

Virginia 22151 19. Security Class (This Report) UNCLASSIFIED 20 . Security Class (This Page UNCLASSIFIED 21. No., of Pages 59’ > 22. Price FORM...Honecker; NEUES DEUTSCHLAND , 23 Aug 78) 1 Belgrade Daily Cites ’PRAVDA’ on Czechoslovakia in 1968 (R. Bajalski; POLITIKA, 21 Aug 78) . 3...Aug 78) 9 Curtailment of West Mark Use For Prostitution Threatened (NEUES DEUTSCHLAND , 8 Aug 78) 10 Briefs Aid for Zimbabwe 11 Friendship

Earth Observation taken during the Expedition 36 mission

NASA Image and Video Library

2013-08-24

ISS036-E-035677 (24 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station used a 50mm lens to record this high oblique view of the massive drought-aided Rim Fire in and around California's Yosemite National Park and the Stanislaus National Forest on Aug. 24. Editor's Note: The fire began on Aug. 17 and, as of Aug. 26, continues to burn. More than 224 square miles have been affected.

60-day safety screen results and final report for tank 241-C-111, auger samples 95-Aug-002, 95-Aug-003, 95-Aug-016, and 95-Aug-017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rice, A.D.

1995-05-30

This report presents the details of the auger sampling events for underground waste tank C-111. The samples were shipped to the 222-S laboratories were they underwent safety screening analysis and primary ferricyanide analysis. The samples were analyzed for alpha total, total organic carbon, cyanide, Ni, moisture, and temperature differentials. The results of this analysis are presented in this document.

Gerst depressurized Kibo for Cubesat deployment

NASA Image and Video Library

2014-08-18

ISS040-E-096126 (18 Aug. 2014) --- In the International Space Station?s Kibo laboratory, European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, depressurizes the Kibo airlock in preparation for a series of NanoRacks CubeSat miniature satellite deployments. The first two pairs of nanosatellites are scheduled for deployment on Aug. 19. The Planet Labs Dove satellites that were carried to the station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25.

Gerst depressurized Kibo for Cubesat deployment

NASA Image and Video Library

2014-08-18

ISS040-E-096122 (18 Aug. 2014) --- In the International Space Station?s Kibo laboratory, European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, depressurizes the Kibo airlock in preparation for a series of NanoRacks CubeSat miniature satellite deployments. The first two pairs of nanosatellites are scheduled for deployment on Aug. 19. The Planet Labs Dove satellites that were carried to the station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25.

Earth Observation

NASA Image and Video Library

2013-08-26

ISS036-E-037185 (26 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station used a 50mm lens to record this view of the massive drought-aided Rim Fire in and around California's Yosemite National Park and the Stanislaus National Forest on Aug. 26. The fire began on Aug. 17 and, at the time of this photo on Aug. 26, it still continues to burn, as some 3,700 firefighters battle it. More than 224 square miles have been affected.

Health Reports.

DTIC Science & Technology

1992-09-01

Futui’e Structure of Veterans’ Health Program (Aug. 11, 1992, GAO/T-HRD-92-53). Recombinant Bovine Growth Hormone: FDA Approval Should be Withheld Until...the Mastitis Issue Is Resolved (Aug. 6, 1992, GAO/PEMD-92-26). VA Health Care: Inadequate Controls Over Scarce Medical Specialist Contracts (Aug. 5

Hurricane Harvey - Aug. 24, 2017

NASA Image and Video Library

2017-08-24

The International Space Station’s external cameras captured a dramatic view of Hurricane Harvey as it bore down on the central Texas coast Aug. 24. The National Hurricane Center predicts a landfall for Harvey near Corpus Christi, Texas early Aug. 26 with potentially record floods expected along the Texas coastline through next week.

48 CFR 1052.234-72 - Core Earned Value Management System AUG 2011

Code of Federal Regulations, 2011 CFR

2011-10-01

... Management System AUG 2011 1052.234-72 Section 1052.234-72 Federal Acquisition Regulations System DEPARTMENT... and Clauses 1052.234-72 Core Earned Value Management System AUG 2011 As prescribed in DTAR 1034.203... an earned value management system (EVMS). (a) The Contractor shall use an earned value management...

48 CFR 1052.234-72 - Core Earned Value Management System AUG 2011

Code of Federal Regulations, 2013 CFR

2013-10-01

... Management System AUG 2011 1052.234-72 Section 1052.234-72 Federal Acquisition Regulations System DEPARTMENT... and Clauses 1052.234-72 Core Earned Value Management System AUG 2011 As prescribed in DTAR 1034.203... an earned value management system (EVMS). (a) The Contractor shall use an earned value management...

48 CFR 1052.234-72 - Core Earned Value Management System AUG 2011

Code of Federal Regulations, 2014 CFR

2014-10-01

... Management System AUG 2011 1052.234-72 Section 1052.234-72 Federal Acquisition Regulations System DEPARTMENT... and Clauses 1052.234-72 Core Earned Value Management System AUG 2011 As prescribed in DTAR 1034.203... an earned value management system (EVMS). (a) The Contractor shall use an earned value management...

Comparative study of spasmolytic properties, antioxidant activity and phenolic content of Arbutus unedo from Montenegro and Greece.

PubMed

Pavlović, Dragana R; Branković, Suzana; Kovačević, Nada; Kitić, Dušanka; Veljković, Slavimir

2011-05-01

Arbutus unedo leaf is used traditionally for gastrointestinal complaints. Ethanol extracts from Arbutus unedo collected in both Montenegro (AuM) and Greece (AuG) were found to decrease the ileal basal tonus, with AuG producing a significantly higher (p < 0.05) reduction in contractile response to acetylcholine. AuM and AuG relaxed 80 mM K(+) induced contractions and shifted the Ca(++) concentration-response curves to the right, similar to that caused by verapamil, suggesting that the spasmolytic effect was induced through calcium channel inhibition. The antioxidant activity of AuM and AuG and the phenolic content of the extracts and dry plant material were studied, and both extracts were found to possess considerable antioxidant properties. AuG showed a stronger in vitro antioxidative activity in the DPPH assay and in the TBA test. Polyphenol, tannin and flavonoid levels were higher in AuG, supporting the more potent spasmolytic and antioxidative effects, whereas the arbutin content was higher in dry plant material collected in Montenegro. Copyright © 2011 John Wiley & Sons, Ltd.

Earth Observation taken during the Expedition 36 mission

NASA Image and Video Library

2013-08-24

ISS036-E-035685 (24 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station used a 50mm lens to record this high oblique view of the massive drought-aided Rim Fire in and around California's Yosemite National Park and the Stanislaus National Forest on Aug. 24. A portion of a solar array panel on the orbital outpost can be seen in upper left corner of the image. Editor's Note: The fire began on Aug. 17 and, as of Aug. 26, continues to burn. More than 224 square miles have been affected.

Operation Desert Shield

Science.gov Websites

Bureau Iraq invades Kuwait, Aug. 2, 1990. Operation Desert Shield begins, Aug. 7, 1990. First U.S. forces Operation Desert Shield-related U.S. death, Aug. 12, 1990. President George Bush authorizes first call-up of Bureau Operation Desert Storm and air war phase begins, 3 a.m., Jan. 17, 1991 (Jan. 16, 7 p.m. Eastern

Upgrade of the BATMAN test facility for H- source development

NASA Astrophysics Data System (ADS)

Heinemann, B.; Fröschle, M.; Falter, H.-D.; Fantz, U.; Franzen, P.; Kraus, W.; Nocentini, R.; Riedl, R.; Ruf, B.

2015-04-01

The development of a radio frequency (RF) driven source for negative hydrogen ions for the neutral beam heating devices of fusion experiments has been successfully carried out at IPP since 1996 on the test facility BATMAN. The required ITER parameters have been achieved with the prototype source consisting of a cylindrical driver on the back side of a racetrack like expansion chamber. The extraction system, called "Large Area Grid" (LAG) was derived from a positive ion accelerator from ASDEX Upgrade (AUG) using its aperture size (ø 8 mm) and pattern but replacing the first two electrodes and masking down the extraction area to 70 cm2. BATMAN is a well diagnosed and highly flexible test facility which will be kept operational in parallel to the half size ITER source test facility ELISE for further developments to improve the RF efficiency and the beam properties. It is therefore planned to upgrade BATMAN with a new ITER-like grid system (ILG) representing almost one ITER beamlet group, namely 5 × 14 apertures (ø 14 mm). Additionally to the standard three grid extraction system a repeller electrode upstream of the grounded grid can optionally be installed which is positively charged against it by 2 kV. This is designated to affect the onset of the space charge compensation downstream of the grounded grid and to reduce the backstreaming of positive ions from the drift space backwards into the ion source. For magnetic filter field studies a plasma grid current up to 3 kA will be available as well as permanent magnets embedded into a diagnostic flange or in an external magnet frame. Furthermore different source vessels and source configurations are under discussion for BATMAN, e.g. using the AUG type racetrack RF source as driver instead of the circular one or modifying the expansion chamber for a more flexible position of the external magnet frame.

Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement.

PubMed

Smirnova, Ekaterina; Firth, Andrew E; Miller, W Allen; Scheidecker, Danièle; Brault, Véronique; Reinbold, Catherine; Rakotondrafara, Aurélie M; Chung, Betty Y-W; Ziegler-Graff, Véronique

2015-05-01

Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The Luteovirus and Polerovirus genera include all but one virus in the Luteoviridae. They share a common gene block, which encodes the coat protein (ORF3), a movement protein (ORF4), and a carboxy-terminal extension to the coat protein (ORF5). These three proteins all have been reported to participate in the phloem-specific movement of the virus in plants. All three are translated from one subgenomic RNA, sgRNA1. Here, we report the discovery of a novel short ORF, termed ORF3a, encoded near the 5' end of sgRNA1. Initially, this ORF was predicted by statistical analysis of sequence variation in large sets of aligned viral sequences. ORF3a is positioned upstream of ORF3 and its translation initiates at a non-AUG codon. Functional analysis of the ORF3a protein, P3a, was conducted with Turnip yellows virus (TuYV), a polerovirus, for which translation of ORF3a begins at an ACG codon. ORF3a was translated from a transcript corresponding to sgRNA1 in vitro, and immunodetection assays confirmed expression of P3a in infected protoplasts and in agroinoculated plants. Mutations that prevent expression of P3a, or which overexpress P3a, did not affect TuYV replication in protoplasts or inoculated Arabidopsis thaliana leaves, but prevented virus systemic infection (long-distance movement) in plants. Expression of P3a from a separate viral or plasmid vector complemented movement of a TuYV mutant lacking ORF3a. Subcellular localization studies with fluorescent protein fusions revealed that P3a is targeted to the Golgi apparatus and plasmodesmata, supporting an essential role for P3a in viral movement.

Discovery of a Small Non-AUG-Initiated ORF in Poleroviruses and Luteoviruses That Is Required for Long-Distance Movement

PubMed Central

Smirnova, Ekaterina; Firth, Andrew E.; Miller, W. Allen; Scheidecker, Danièle; Brault, Véronique; Reinbold, Catherine; Rakotondrafara, Aurélie M.; Chung, Betty Y.-W.; Ziegler-Graff, Véronique

2015-01-01

Viruses in the family Luteoviridae have positive-sense RNA genomes of around 5.2 to 6.3 kb, and they are limited to the phloem in infected plants. The Luteovirus and Polerovirus genera include all but one virus in the Luteoviridae. They share a common gene block, which encodes the coat protein (ORF3), a movement protein (ORF4), and a carboxy-terminal extension to the coat protein (ORF5). These three proteins all have been reported to participate in the phloem-specific movement of the virus in plants. All three are translated from one subgenomic RNA, sgRNA1. Here, we report the discovery of a novel short ORF, termed ORF3a, encoded near the 5’ end of sgRNA1. Initially, this ORF was predicted by statistical analysis of sequence variation in large sets of aligned viral sequences. ORF3a is positioned upstream of ORF3 and its translation initiates at a non-AUG codon. Functional analysis of the ORF3a protein, P3a, was conducted with Turnip yellows virus (TuYV), a polerovirus, for which translation of ORF3a begins at an ACG codon. ORF3a was translated from a transcript corresponding to sgRNA1 in vitro, and immunodetection assays confirmed expression of P3a in infected protoplasts and in agroinoculated plants. Mutations that prevent expression of P3a, or which overexpress P3a, did not affect TuYV replication in protoplasts or inoculated Arabidopsis thaliana leaves, but prevented virus systemic infection (long-distance movement) in plants. Expression of P3a from a separate viral or plasmid vector complemented movement of a TuYV mutant lacking ORF3a. Subcellular localization studies with fluorescent protein fusions revealed that P3a is targeted to the Golgi apparatus and plasmodesmata, supporting an essential role for P3a in viral movement. PMID:25946037

Astronaut L. Gordon Cooper Jr. - Misc. - Gemini-Titan (GT)-5 - Suiting-Up - Prime Crew - Cape

NASA Image and Video Library

1965-08-19

S65-46367 (19 Aug. 1965) --- Astronauts Charles Conrad Jr. (right) and L. Gordon Cooper Jr. are pictured during suiting up operations before Gemini-5 spaceflight. Editor's note: The scheduled Aug. 19 launch was postponed due to weather conditions and problems with loading cryogenic fuel for the fuel cell. The launch occurred on Aug. 21, 1965.

14 CFR 21.27 - Issue of type certificate: surplus aircraft of the Armed Forces.

Code of Federal Regulations, 2012 CFR

2012-01-01

... that apply 1 Small reciprocating-engine powered airplanes Before May 16, 1956After May 15, 1956 CAR Part 3, as effective May 15, 1956.CAR Part 3, or 14 CFR Part 23. Small turbine engine-powered airplanes...-engine powered airplanes Before Aug. 26, 1955After Aug. 25, 1955 CAR Part 4b, as effective Aug. 25, 1955...

14 CFR 21.27 - Issue of type certificate: surplus aircraft of the Armed Forces.

Code of Federal Regulations, 2013 CFR

2013-01-01

... that apply 1 Small reciprocating-engine powered airplanes Before May 16, 1956After May 15, 1956 CAR Part 3, as effective May 15, 1956.CAR Part 3, or 14 CFR Part 23. Small turbine engine-powered airplanes...-engine powered airplanes Before Aug. 26, 1955After Aug. 25, 1955 CAR Part 4b, as effective Aug. 25, 1955...

14 CFR 21.27 - Issue of type certificate: surplus aircraft of the Armed Forces.

Code of Federal Regulations, 2014 CFR

2014-01-01

... that apply 1 Small reciprocating-engine powered airplanes Before May 16, 1956After May 15, 1956 CAR Part 3, as effective May 15, 1956.CAR Part 3, or 14 CFR Part 23. Small turbine engine-powered airplanes...-engine powered airplanes Before Aug. 26, 1955After Aug. 25, 1955 CAR Part 4b, as effective Aug. 25, 1955...

Discovery of Possible Bright Nova in NGC891 : P60-NGC891-080813

NASA Astrophysics Data System (ADS)

Kasliwal, M. M.; Cenko, S. B.; Rau, A.; Ofek, E. O.; Quimby, R.; Kulkarni, S. R.

2008-08-01

On UT 2008 Aug 13.45, P60-FasTING (Palomar 60-inch Fast Transients In Nearby Galaxies) discovered an optical transient at RA(J2000)=02:22:32.70, DEC(J2000)=42:21:56.1 in the field of NGC891. P60-NGC891-080813 is offset from the nucleus of NGC891 by 8"W,59"N. The light curve thus far is g>22 (Jul 30.48), g=21.2 (Aug 13.45), g=21.0 (Aug 14.32), g=21.0 (Aug 15.32). Photometric calibration is wrt USNO-B1 and uncertain by 0.2 mags.

Nanoracks CUBESAT launcher operations

NASA Image and Video Library

2014-08-19

ISS040-E-102490 (19 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer releases a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at left.

Nanoracks CUBESAT launcher

NASA Image and Video Library

2014-08-20

ISS040-E-102420 (20 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer releases a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at left.

Nanoracks CUBESAT launcher

NASA Image and Video Library

2014-08-20

ISS040-E-102425 (20 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer releases a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at left.

Health Reports

DTIC Science & Technology

1992-11-01

Food and Drug Recombinant Bovine Growth Hormone: FDA Approval Should Be Withheld Administration Until the Mastitis Issue Is Resolved (Report, Aug. 6...Care: Demonstration Project Concerning Future Structure of Veterans’ Health Program (Testimony, Aug. 11, 1992, GA(Yr-HRD-92-53). Recombinant Bovine ...Growth Hormone: FDA Approval Should Be Withheld Until the Mastitis Issue Is Resolved (Report, Aug. 6, 1992, GAO/PEMD-92-26). Page 10 GAD/RRD-98-38 Health

Combat Support Forces (1C6C) Naval Surface Forces Requirements-based Budget Determination for Assault Craft Unit ONE

DTIC Science & Technology

2009-06-01

228,027 AUG 31,098 107,135 AUG - AUG 38,869 136,669 SEP 81,005 166,854 SEP 215,648 551,379 SEP - SEP 16,505 83,549 USS WHIPPLE (FF...Naval Supply System Command: Afloat Supply Procedures : Volume II. Retrived May 18, 2009, from Navy Storekeeper website: http://www.navystorekeeper.com

China Report, Agriculture, No. 278.

DTIC Science & Technology

1983-11-10

Radiation Successfully Used in Agriculture (XINHUA, 18 Oct 83) 2 Recent Agricultural Development Strategies (Zhang Lin; JINGJI YANJIU, No 9, 20...ABSTRACTS SOIL CONSERVATION SHUITU BAOCHI TONGBAO [BULLETIN OF SOIL AND WATER CONSERVATION], No 4, Aug 83 28 URBAN STUDIES JINGJI DILI [ECONOMIC...GEOGRAPHY], No 3, Aug 83 31 LAND USE JINGJI DILI [ECONOMIC GEOGRAPHY], No 3, Aug 83 33 CROP ROTATION JINGJI DILI fECONOMIC GEOGRAPHY], No

Effect of the nucleotides surrounding the start codon on the translation of foot-and-mouth disease virus RNA.

PubMed

Ma, X X; Feng, Y P; Gu, Y X; Zhou, J H; Ma, Z R

2016-06-01

As for the alternative AUGs in foot-and-mouth disease virus (FMDV), nucleotide bias of the context flanking the AUG(2nd) could be used as a strong signal to initiate translation. To determine the role of the specific nucleotide context, dicistronic reporter constructs were engineered to contain different versions of nucleotide context linking between internal ribosome entry site (IRES) and downstream gene. The results indicate that under FMDV IRES-dependent mechanism, the nucleotide contexts flanking start codon can influence the translation initiation efficiencies. The most optimal sequences for both start codons have proved to be UUU AUG(1st) AAC and AAG AUG(2nd) GAA.

Nanoracks CUBESAT launcher

NASA Image and Video Library

2014-08-20

ISS040-E-102410 (20 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer is about to release a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at left.

GEMINI-TITAN (GT)-V - PILOT - SUITING-UP - CAPE

NASA Image and Video Library

1965-08-19

S65-46374 (21 Aug. 1965) --- Astronaut Charles Conrad Jr., Gemini-5 pilot, is pictured during suiting up operations on the morning of the flight of Gemini-5. With him is Dr. Eugene Tubbs, a member of the medical team at Cape Kennedy. The mission was originally set for Aug. 19, 1965, but was scrubbed and reset for Aug. 21. Command pilot for the flight is astronaut L. Gordon Cooper Jr.

Headlines Previous Editions

Science.gov Websites

Feb 2018 Jan 2018 Dec 2017 Nov 2017 Oct 2017 Sep 2017 Aug 2017 Jul 2017 Jun 2017 May 2017 APR 2017 MAR 2017 FEB 2017 JAN 2017 DEC 2016 NOV 2016 OCT 2016 SEP 2016 AUG 2016 JUL 2016 JUN 2016 MAY 2016 APR 2016 MAR 2016 FEB 2016 JAN 2016 DEC 2015 NOV 2015 OCT 2015 SEP 2015 AUG 2015 JUL 2015 JUN 2015 MAY 2015 APR

Alterations of the three short open reading frames in the Rous sarcoma virus leader RNA modulate viral replication and gene expression.

PubMed Central

Moustakas, A; Sonstegard, T S; Hackett, P B

1993-01-01

The Rous sarcoma virus (RSV) leader RNA has three short open reading frames (ORF1 to ORF3) which are conserved in all avian sarcoma-leukosis retroviruses. Effects on virus propagation were determined following three types of alterations in the ORFs: (i) replacement of AUG initiation codons in order to prohibit ORF translation, (ii) alterations of the codon context around the AUG initiation codon to enhance translation of the normally silent ORF3, and (iii) elongation of the ORF coding sequences. Mutagenesis of the AUG codons for ORF1 and ORF2 (AUG1 and AUG2) singly or together delayed the onset of viral replication and cell transformation. In contrast, mutagenesis of AUG3 almost completely suppressed these viral activities. Mutagenesis of ORF3 to enhance its translation inhibited viral propagation. When the mutant ORF3 included an additional frameshift mutation which extended the ORF beyond the initiation site for the gag, gag-pol, and env proteins, host cells were initially transformed but died soon thereafter. Elongation of ORF1 from 7 to 62 codons led to the accumulation of transformation-defective virus with a delayed onset of replication. In contrast, viruses with elongation of ORF1 from 7 to 30 codons, ORF2 from 16 to 48 codons, or ORF3 from 9 to 64 codons, without any alterations in the AUG context, exhibited wild-type phenotypes. These results are consistent with a model that translation of the ORFs is necessary to facilitate virus production. Images PMID:7685415

Isolation and characterization of Lepidoptera specific Bacillus thuringiensis strains predominantly from north-eastern states of India.

PubMed

Tripathi, Monika; Kumar, Arvind; Kalia, Vinay; Saxena, A K; Gujar, Govind

2016-07-01

Both, the tobacco caterpillar Spodoptera litura (Fabricius) and the cotton bollworm Helicoverpa armigera (Hibner), are serious polyphagous pests causing considerable loss to crops. Indiscriminate use of chemical pesticides for controlling them has rather resulted in their resistance development. Microbial pesticides, Bacillus thuringiensis in particular, play an important role in pest management. Here, we isolated Bacillus thuringiensis-like bacteria from the soil samples primarily collected from North East region of India along with some states viz., Haryana, Punjab, Maharashtra, West Bengal and Uttarakhand and studied their toxicity against the above two insect pests at 10 gg/g along with standard strain B. thuringiensis subsp. kurstaki HD-I and at 1 pg/g Pseudomonasfluorescens based MVPII expressing CrylAc toxin and AUG-5. Isolates AUG-5 and GTG-7 proved toxic to more than 75% larvae on the 4h as well as 7h day of the treatment of the neonates of H. armigera. The AUG-5 isolate was also effective against S. litura. Ten effective isolates (AUG-5, GTG-4, GTG-7, GTG-9, GTG-42, GTG-64, GTG-70, GTG-3S, GTG-4S and GTG-6S) were characterized using biochemical and 16S rDNA analysis. Nearly, all the isolates tested positive for utilizing monosaccharides. All selected B. thuringiensis isolates showed resistance to ampicillin and co-trimoxazole except AUG-5 to- co-trimoxazole. AUG-5 and GTG-7 were highly toxic to both insects, and possessed cryl, cry1A and cry2 genes. These isolates AUG-5 and GTG-7 also contained high CrylAc (104.8 and 88.32 ng/mg) and Cry2Ab (3792 and 1305.9 ng/mg), respectively in their spore-crystal complex. Both, AUG-5 and GTG-7 isolates, could be considered for further development as bioinsecticides. The present study has established the diversity and richness of B. thuringiensis-like isolates in soils collected from north-eastern region of India.

The behavior of a compressible turbulent boundary layer in a shock-wave-induced adverse pressure gradient. Ph.D. Thesis - Washington Univ., Seattle, Aug. 1972

NASA Technical Reports Server (NTRS)

Rose, W. C.

1973-01-01

The results of an experimental investigation of the mean- and fluctuating-flow properties of a compressible turbulent boundary layer in a shock-wave-induced adverse pressure gradient are presented. The turbulent boundary layer developed on the wall of an axially symmetric nozzle and test section whose nominal free-stream Mach number and boundary-layer thickness Reynolds number were 4 and 100,000, respectively. The adverse pressure gradient was induced by an externally generated conical shock wave. Mean and time-averaged fluctuating-flow data, including the complete experimental Reynolds stress tensor and experimental turbulent mass- and heat-transfer rates are presented for the boundary layer and external flow, upstream, within and downstream of the pressure gradient. The mean-flow data include distributions of total temperature throughout the region of interest. The turbulent mixing properties of the flow were determined experimentally with a hot-wire anemometer. The calibration of the wires and the interpretation of the data are discussed. From the results of the investigation, it is concluded that the shock-wave - boundary-layer interaction significantly alters the turbulent mixing characteristics of the boundary layer.

Cryptic out-of-frame translational initiation of TBCE rescues tubulin formation in compound heterozygous HRD.

PubMed

Tian, Guoling; Huang, Melissa C; Parvari, Ruti; Diaz, George A; Cowan, Nicholas J

2006-09-05

Microtubules are indispensable dynamic structures that contribute to many essential biological functions. Assembly of the native alpha/beta tubulin heterodimer, the subunit that polymerizes to form microtubules, requires the participation of several molecular chaperones, namely prefoldin, the cytosolic chaperonin CCT, and a series of five tubulin-specific chaperones termed cofactors A-E (TBCA-E). Among these, TBCC, TBCD, and TBCE are essential in higher eukaryotes; they function together as a multimolecular machine that assembles quasinative CCT-generated alpha- and beta-tubulin polypeptides into new heterodimers. Deletion and truncation mutations in the gene encoding TBCE have been shown to cause the rare autosomal recessive syndrome known as HRD, a devastating disorder characterized by congenital hypoparathyroidism, mental retardation, facial dysmorphism, and extreme growth failure. Here we identify cryptic translational initiation at each of three out-of-frame AUG codons upstream of the genetic lesion as a unique mechanism that rescues a mutant HRD allele by producing a functional TBCE protein. Our data explain how afflicted individuals, who would otherwise lack the capacity to make functional TBCE, can survive and point to a limiting capacity to fold tubulin heterodimers de novo as a contributing factor to disease pathogenesis.

Cryptic out-of-frame translational initiation of TBCE rescues tubulin formation in compound heterozygous HRD

PubMed Central

Tian, Guoling; Huang, Melissa C.; Parvari, Ruti; Diaz, George A.; Cowan, Nicholas J.

2006-01-01

Microtubules are indispensable dynamic structures that contribute to many essential biological functions. Assembly of the native α/β tubulin heterodimer, the subunit that polymerizes to form microtubules, requires the participation of several molecular chaperones, namely prefoldin, the cytosolic chaperonin CCT, and a series of five tubulin-specific chaperones termed cofactors A–E (TBCA–E). Among these, TBCC, TBCD, and TBCE are essential in higher eukaryotes; they function together as a multimolecular machine that assembles quasinative CCT-generated α- and β-tubulin polypeptides into new heterodimers. Deletion and truncation mutations in the gene encoding TBCE have been shown to cause the rare autosomal recessive syndrome known as HRD, a devastating disorder characterized by congenital hypoparathyroidism, mental retardation, facial dysmorphism, and extreme growth failure. Here we identify cryptic translational initiation at each of three out-of-frame AUG codons upstream of the genetic lesion as a unique mechanism that rescues a mutant HRD allele by producing a functional TBCE protein. Our data explain how afflicted individuals, who would otherwise lack the capacity to make functional TBCE, can survive and point to a limiting capacity to fold tubulin heterodimers de novo as a contributing factor to disease pathogenesis. PMID:16938882

Translations on Eastern Europe, Political, Sociological and Military Affairs, Number 1598.

DTIC Science & Technology

1978-10-17

Approved for Public Release Distribution Unlimited 20000414 091 U. S. JOINT PUBLICATIONS RESEARCH SERVICE Reproduced From Best Available Copy i M ■1...MUNCA DE PARTID, Aug 78) 52 More Militancy Needed in Publications for Youth ( Alecu Popovici; ERA SOCIALISTA, 20 Aug 78) 58 Briefs...PUBLICATIONS FOR YOUTH Bucharest ERA SOCIALISTA in Romanian No 16, 20 Aug 78 pp 36, 37 /Article by Alecu Popovici_7 ZText/ Analyzing all the great literary

77 FR 45925 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

.... 97.20 of Title 14 of the Code of Federal Regulations. The large number of SIAPs, their complex nature........... Albert J Ellis...... 2/4274 7/11/12 RNAV (GPS) RWY 5, Amdt 1. 23-Aug-12 MN Luverne Quentin Aanenson 2.... 23-Aug-12 MN Owatonna Owatonna Degner Rgnl 2/7931 7/11/12 ILS OR LOC RWY 30, Amdt 2A. 23-Aug-12 WI...

HTV-4 approach

NASA Image and Video Library

2013-08-09

ISS036-E-030064 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time).

HTV-4 approach

NASA Image and Video Library

2013-08-09

ISS036-E-029969 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time).

HTV-4 approach

NASA Image and Video Library

2013-08-09

ISS036-E-029963 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time).

HTV-4 approach

NASA Image and Video Library

2013-08-09

ISS036-E-030067 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time).

Naval Health Research Center Command Annual Report Calendar Year 1987 and FY-88

DTIC Science & Technology

1988-01-01

1044-1055). Conference Proceedings Space 󈨜, 29-31 Aug 88, Albuquerque, New Mexico . 1988, New York: American Society of Civil Engineers. (Center...Proceedings Space 󈨜, 29-31 Aug 88, Albuquerque, New Mexico . 1988, New York: American Society of Civil Engineers. Work Unit: Army 3MI62770.A87@.AR...New Mexico , 29-31 Aug 88 Dr. Palinkas - "The Human Experience in Space: Lessons from Antarctica" Association of Professional Sleep Societies Meetings

Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexes

PubMed Central

Zhang, Fan; Saini, Adesh K.; Shin, Byung-Sik; Nanda, Jagpreet; Hinnebusch, Alan G.

2015-01-01

The translation preinitiation complex (PIC) is thought to assume an open conformation when scanning the mRNA leader, with AUG recognition evoking a closed conformation and more stable P site interaction of Met-tRNAi; however, physical evidence is lacking that AUG recognition constrains interaction of mRNA with the 40S binding cleft. We compared patterns of hydroxyl radical cleavage of rRNA by Fe(II)-BABE tethered to unique sites in eIF1A in yeast PICs reconstituted with mRNA harboring an AUG or near-cognate (AUC) start codon. rRNA residues in the P site display reduced cleavage in AUG versus AUC PICs; and enhanced cleavage in the AUC complexes was diminished by mutations of scanning enhancer elements of eIF1A that increase near-cognate recognition in vivo. This suggests that accessibility of these rRNA residues is reduced by accommodation of Met-tRNAi in the P site (PIN state) and by their interactions with the anticodon stem of Met-tRNAi. Our cleavage data also provide evidence that AUG recognition evokes dissociation of eIF1 from its 40S binding site, ejection of the eIF1A-CTT from the P-site and rearrangement to a closed conformation of the entry channel with reduced mobility of mRNA. PMID:25670678

First Pressure Readings on Mars

NASA Image and Video Library

2012-08-21

This graph shows readings for atmospheric pressure at the landing site of NASA Curiosity rover. The data were obtained by Curiosity Rover Environmental Monitoring Station from Aug. 15 to Aug. 18, 2012.

3 CFR 102.171-102.999 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-01-01

... Month, 2012 55091 8852 Aug. 31 National Childhood Obesity Awareness Month, 2012 55093 8853 Aug. 31...)Child Health Day (Proc. 8880)Childhood Cancer Awareness Month, National (Proc. 8851)Childhood Obesity...

3 CFR 102.171-102.999 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-01-01

..., 2013 54737 9007 Aug. 30 National Childhood Obesity Awareness Month, 2013 54739 9008 Aug. 30 National... Health Day (Proc. 9036)Childhood Cancer Awareness Month, National (Proc. 9006)Childhood Obesity Awareness...

KSC-08pd2429

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – At NASA's Kennedy Space Center, this alligator was spotted cruising the flood waters caused by Tropical Storm Fay. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

Nanoracks CUBESAT launcher

NASA Image and Video Library

2014-08-19

ISS040-E-103506 (19 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer is about to release a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. The station?s Kibo laboratory is at top right. A blue and white part of Earth and the blackness of space provide the backdrop for the scene.

Nanoracks CUBESAT launcher operations

NASA Image and Video Library

2014-08-20

ISS040-E-103340 (20 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer (upper right) releases a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at center. A blue and white part of Earth and the blackness of space provide the backdrop for the scene.

Climate Prediction Center - Seasonal Outlook

Science.gov Websites

maps) Norm Prob of Exceed (Interactive) T P 0.5 Month Outlook for Jun-Jul-Aug 2018 N T P 1.5 Month Outlook for Jul-Aug-Sep 2018 N T P 2.5 Month Outlook for Aug-Sep-Oct 2018 N T P 3.5 Month Outlook for Sep -Oct-Nov 2018 N T P 4.5 Month Outlook for Oct-Nov-Dec 2018 N T P 5.5 Month Outlook for Nov-Dec-Jan 2018

2. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (b) EXT.-FRONT, LOOKING NORTHWEST - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

9. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (i) INT.- MANTEL, SOUTHEAST ROOM, 2nd. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

7. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (g) INT.- MANTEL, SOUTHWEST ROOM, 1st. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

10. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (j) INT.-MANTEL, SOUTHWEST ROOM, 2nd. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

1. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (a) EXT.-VIEW OF FRONT, LOOKING NORTHWEST - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

13. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (l) INT.-PANELED WALL & FIREPLACE, GUEST HOUSE - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

12. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 3, 1938 (k) INT.- MANTLE, NORTHEAST ROOM, 2nd. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

Identification of the initiation site of poliovirus polyprotein synthesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dorner, A.J.; Dorner, L.F.; Larsen, G.R.

1982-06-01

The complete nucleotide sequence of poliovirus RNA has a long open reading frame capable of encoding the precursor polyprotein NCVPOO. The first AUG codon in this reading frame is located 743 nucleotides from the 5' end of the RNA and is preceded by eight AUG codons in all three reading frames. Because all proteins that map at the amino terminus of the polyprotein (P1-1a, VPO, and VP4) are blocked at their amino termini and previous studies of ribosome binding have been inconclusive, direct identification of the initiation site of protein synthesis was difficult. We separated and identified all of themore » tryptic peptides of capsid protein VP4 and correlated these peptides with the amino acid sequence predicted to follow the AUG codon at nucleotide 743. Our data indicate that VP4 begins with a blocked glycine that is encoded immediately after the AUG codon at nucleotide 743. An S1 nuclease analysis of poliovirus mRNA failed to reveal a splice in the 5' region. We concluded that synthesis of poliovirus polyprotein is initiated at nucleotide 743, the first AUG codon in the long open reading frame.« less

11. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (m) INT.-WALL PAPER, SOUTHWEST ROOM, 2nd. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

8. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey Arthur C. Haskell, Photographer Aug. 30, 1938 (h) INT.- NORTH WALL, SOUTHEAST ROOM, 1st. FLOOR - Captain William Wildes House, 872 Commercial Street, Weymouth, Norfolk County, MA

Curiosity Flying Over Mars

NASA Image and Video Library

2012-08-06

NASA Curiosity rover and its parachute were spotted by NASA Mars Reconnaissance Orbiter as Curiosity descended to the surface on Aug. 5 PDT Aug. 6 EDT. Curiosity and its parachute are in the small white box at center.

Mars Weather Map, Aug. 4, 2012

NASA Image and Video Library

2012-08-05

This global map of Mars was acquired on Aug. 4, 2012, by the Mars Color Imager instrument on NASA Mars Reconnaissance Orbiter to forecast weather conditions for the entry, descent and landing of NASA Curiosity rover.

KSC-08pd2422

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – Debris covers a road eroded by Tropical Storm Fay near Launch Pad 39A at NASA's Kennedy Space Center. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

KSC-08pd2424

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – Wind and rain from Tropical Storm Fay pummel the area near the Vehicle Assembly Building at NASA's Kennedy Space Center. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

KSC-08pd2430

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – Due to Tropical Storm Fay, the ground is flooded on a road alongside the turn basin at NASA's Kennedy Space Center. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

KSC-08pd2423

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – Flooding and some tree damage near the Vehicle Assembly Building are results from Tropical Storm Fay at NASA's Kennedy Space Center. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

KSC-08pd2431

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – Due to Tropical Storm Fay, the roadside canals and surrounding grounds are flooded at NASA's Kennedy Space Center. In the background is the Vehicle Assembly Building. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Ben Smegelsky

KSC-08pd2428

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – An alligator seeks higher ground alongside a road at NASA's Kennedy Space Center during the onslaught of Tropical Storm Fay. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

Nanoracks CUBESAT launcher operations

NASA Image and Video Library

2014-08-20

ISS040-E-103327 (20 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer (upper right) is about to release a pair of NanoRacks CubeSat miniature satellites. The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at center. A blue and white part of Earth and the blackness of space provide the backdrop for the scene.

Nanoracks CUBESAT launcher operations

NASA Image and Video Library

2014-08-19

ISS040-E-103545 (19 Aug. 2014) --- In the grasp of the Japanese robotic arm, the CubeSat deployer (mostly out of frame, upper right) releases a pair of NanoRacks CubeSat miniature satellites (center). The Planet Labs Dove satellites that were carried to the International Space Station aboard the Orbital Sciences Cygnus commercial cargo craft are being deployed between Aug. 19 and Aug. 25. A section of the station solar array wings is at top right. A blue and white part of Earth and the blackness of space provide the backdrop for the scene.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Moon's Shadow Seen From Gulfstream III Aircraft, Off Oregon Coast)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21 NASA provided coast-to-coast coverage of the solar eclipse across America- featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during live broadcast seen on NASA Television and the agency’s website. Footage of the moon's shadow moving across the planet is captured from NASA's Gulfstream III aircraft as it flew in the skies off the coast of Oregon during the Aug. 21 solar eclipse

Air Force Combat Wings: Lineage and Honors Histories, 1947-1977

DTIC Science & Technology

1984-06-01

bendwise. 1949-30 Apr 195. Group. 22d: 1 Aug Motto: FORTITUDO ET PRE - 1948-16 Jun 1952 (detached 1 Aug 41 71. 777.- - - COMBAT WINGS 1948-30 Jun 1949, 14...all within ; 1973; 0-2, 1971-; A-7, 1972-. diminished b,’rdure of the last. MGtto: Operutions. Served in the defense of LOS PROFESIONALES -The profes...S 13 Jul 1959; Col Samuel Gy. Porterfield, 20 Aug 1959; Maj Gen Jol-ph J. Pres - ’’"T ton, 12 Oct 1959; Brig Gen William E. Creer, 28 Sep 1960; Brig

H-II Transfer Vehicle (HTV)-4

NASA Image and Video Library

2013-08-09

ISS036-E-030702 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time). A blue and white part of Earth provides the backdrop for the scene.

H-II Transfer Vehicle (HTV)-4

NASA Image and Video Library

2013-08-09

ISS036-E-030638 (9 Aug. 2013) --- The unpiloted Japanese "Kounotori" H2 Transfer Vehicle-4 (HTV-4) approaches the International Space Station. The HTV, a 33-foot-long, 13-foot-diameter unmanned cargo transfer spacecraft, is delivering 3.6 tons of science experiments, equipment and supplies to the orbiting complex. HTV-4 launched from the Tanegashima Space Center in southern Japan on Aug.3 at 3:48 p.m. (Aug. 4 at 4:48 a.m., Japan time). A blue and white part of Earth provides the backdrop for the scene.

Particle Data Group - Downloads

Science.gov Websites

1977 1976 1975 1974 1973 1972 1971 Older Publications Review of Particle Properties 1970 Aug. Review of Particle Properties 1970 Jan. Review of Particle Properties 1969 Review of Particle Properties 1968 Aug

Curiosity Spotted on Parachute by Orbiter

NASA Image and Video Library

2012-08-06

NASA Curiosity rover and its parachute were spotted by NASA Mars Reconnaissance Orbiter as Curiosity descended to the surface on Aug. 5 PDT Aug. 6 EDT. Curiosity and its parachute are in the center of the white box.

2. Historic American Buildings Survey Frank O. Branzetti, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey Frank O. Branzetti, Photographer Aug. 6, 1940 (y) 3- MILE STONE, 45 CENTRE ST., ROXBURY - Milestones D, Y, Z, AA, BB, FF & NN, Various Roxbury locations, Roxbury, Suffolk County, MA

Growth of well-aligned ZnO nanorods using auge catalyst by vapor phase transportation.

PubMed

Ha, S Y; Jung, M N; Park, S H; Ko, H J; Ko, H; Oh, D C; Yao, T; Chang, J H

2006-11-01

Well-aligned ZnO nanorods have been achieved using new alloy (AuGe) catalyst. Zn powder was used as a source material and it was transported in a horizontal tube furnace onto an AuGe deposited Si substrates. The structural and optical properties of ZnO nanorods were characterized by scanning electron microscopy, high resolution X-ray diffraction, and photoluminescence. ZnO nanorods grown at 650 degrees C on 53 nm thick AuGe layer show uniform shape with the length of 8 +/- 0.5 microm and the diameter of 150 +/- 5 nm. Also, the tilting angle of ZnO nanorods (+/- 5.5 degrees) is confirmed by HRXRD. High structural quality of the nanorods is conformed by the photoluminescence measurement. All samples show strong UV emission without considerable deep level emission. However, weak deep level emission appears at high (700 degrees C) temperature due to the increase of oxygen desertion.

Synthesis and characterization of poly(propylene imine)-dendrimer-grafted gold nanoparticles as nanocarriers of doxorubicin.

PubMed

Golshan, Marzieh; Salami-Kalajahi, Mehdi; Mirshekarpour, Mina; Roghani-Mamaqani, Hossein; Mohammadi, Maryam

2017-07-01

The aim of current work is synthesis 4th-generation-poly(propylene imine) (PPI)-dendrimer modified gold nanoparticles (Au-G4A) as nanocarriers for doxorubicin (DOX) and studying in vitro drug release kinetics from nanocarriers into different media. Accordingly, AuNPs were synthesized by reduction of chloroauric acid (HAuCl 4 ) aqueous solution with trisodium citrate and modified with cysteamine to obtain amine-functionalized (Au-NH 2 ) nanoparticles. Au-NH 2 nanoparticles were used as multifunctional cores and participated in Michael addition of acrylonitrile and reduction process by lithium aluminum hydride (LAH) to synthesize Au-G4A nanoparticles. Also, peripheral primary amine groups of Au-G4A were conjugated with folic acid (FA) (Au-G4F) to study the bioconjugation effect on drug release behavior of nanostructures. Ultraviolet spectroscopy (UV-vis), atomic force microscopy (AFM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and thermal gravimetric analysis (TGA) were used to approve the synthesis of different nanostructures. Finally, Au-G4A and Au-G4F samples were loaded with DOX and exposed to environments with different pH values to examine the release properties of nanostructures. Also, drug release kinetics was investigated by fitting of experimental data with different release models. As a result, synthesized dendritic structures showed Higuchi and Korsmeyer-Peppas models release behavior due to better solubility of drug in release media with respect to dendrimer cavities and drug release through polymeric matrix respectively. Copyright © 2017 Elsevier B.V. All rights reserved.

Geological Diversity at Curiosity Landing Site

NASA Image and Video Library

2012-07-16

The area where NASA Curiosity rover will land on Aug. 5 PDT Aug. 6 EDT has a geological diversity that scientists are eager to investigate, as seen in this false-color map based on data from NASA Mars Odyssey orbiter.

Location of John Klein Drill Site

NASA Image and Video Library

2013-03-12

This false-color map shows the area within Gale Crater on Mars, where NASA Curiosity rover landed on Aug. 5, 2012 PDT Aug. 6, 2012 EDT and the location where Curiosity collected its first drilled sample at the John Klein rock.

Mars Weather Map, Aug. 5

NASA Image and Video Library

2012-08-10

This global map of Mars was acquired on Aug. 5, 2012, by the Mars Color Imager instrument on NASA MRO. One global map is generated each day to forecast weather conditions for the entry, descent and landing of NASA Curiosity rover.

4. Historic American Buildings Survey Frank O. Branzetti, Photographer Aug. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey Frank O. Branzetti, Photographer Aug. 8, 1940 (z) 4- MILE STONE, 366c CENTRE ST., ROXBURY - Milestones D, Y, Z, AA, BB, FF & NN, Various Roxbury locations, Roxbury, Suffolk County, MA

ASTER Views Large Calving Event at Petermann Glacier, Greenland

NASA Image and Video Library

2010-08-12

This image of Petermann Glacier and the new iceberg was acquired from NASA Terra spacecraft on Aug. 12, 2010. On Aug. 5, 2010, an enormous chunk of ice broke off the Petermann Glacier along the northwestern coast of Greenland.

Skylab Astronaut participates in EVA to deploy twin pole solar shield

NASA Image and Video Library

1973-08-06

SL3-118-2182 (6 Aug. 1973) --- Skylab 3 astronaut participates in the Aug. 6, 1973 extravehicular activity (EVA) during which the twin pole solar shield was deployed to help shade the Orbital Workshop (OWS). Photo credit: NASA

Overnight Changes Recorded by Phoenix Conductivity Probe

NASA Image and Video Library

2008-12-15

This graph presents simplified data from overnight measurements by the Thermal and Electrical Conductivity Probe on NASA Phoenix Mars Lander from noon of the mission 70th Martian day, or sol, to noon the following sol Aug. 5 to Aug. 6, 2008.

Mars Weather Map, Aug. 2, 2012

NASA Image and Video Library

2012-08-04

This global map of Mars was acquired on Aug. 2, 2012, by the Mars Color Imager instrument on NASA Mars Reconnaissance Orbiter. One global map is generated each day to forecast weather conditions for the entry, descent and landing of NASA Curiosity.

Earth Observation taken during the Expedition 36 mission

NASA Image and Video Library

2013-08-24

ISS036-E-035683 (24 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station used a 50mm lens to record this image of massive wildfires in and around California's Yosemite National Park on Aug. 24.

41 CFR 101-26.311 - Frustrated shipments.

Code of Federal Regulations, 2014 CFR

2014-07-01

... destination which, while en route, cannot be continued onward for any reason and for which the consignee or... this § 101-26.311 on a case by case basis. [30 FR 11138, Aug. 28, 1965, as amended at 35 FR 12721, Aug...

41 CFR 101-26.311 - Frustrated shipments.

Code of Federal Regulations, 2013 CFR

2013-07-01

... destination which, while en route, cannot be continued onward for any reason and for which the consignee or... this § 101-26.311 on a case by case basis. [30 FR 11138, Aug. 28, 1965, as amended at 35 FR 12721, Aug...

41 CFR 101-26.311 - Frustrated shipments.

Code of Federal Regulations, 2011 CFR

2011-07-01

... destination which, while en route, cannot be continued onward for any reason and for which the consignee or... this § 101-26.311 on a case by case basis. [30 FR 11138, Aug. 28, 1965, as amended at 35 FR 12721, Aug...

41 CFR 101-26.311 - Frustrated shipments.

Code of Federal Regulations, 2012 CFR

2012-07-01

... destination which, while en route, cannot be continued onward for any reason and for which the consignee or... this § 101-26.311 on a case by case basis. [30 FR 11138, Aug. 28, 1965, as amended at 35 FR 12721, Aug...

KCBX Letter to EPA - Aug. 27, 2014

EPA Pesticide Factsheets

A quality control check revealed that temperature data for June 26-Aug. 6, 2014 from the meteorological monitor at NT-NW was not accurate. KCBX replaced the invalidated data with hourly ambient temperature data from other equipment and sent updated files.

KSC-08pd2502

NASA Image and Video Library

2008-08-23

CAPE CANAVERAL, Fla. – This aerial view shows the high water surrounding Launch Pad 39A at NASA's Kennedy Space Center following Tropical Storm Fay. In the foreground is the Atlantic Ocean. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Amanda Diller

KSC-08pd2427

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – The median of one of the roads on NASA's Kennedy Space Center is flooded from Tropical Storm Fay. An emergency vehicle illustrates the flooding on the road as well. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

KSC-08pd2503

NASA Image and Video Library

2008-08-23

CAPE CANAVERAL, Fla. – Launch Pad 39A seems to be an island in the high water surrounding it caused by Tropical Storm Fay. In the distance is the Atlantic Ocean. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Amanda Diller

Distance between RBS and AUG plays an important role in overexpression of recombinant proteins.

PubMed

Berwal, Sunil K; Sreejith, R K; Pal, Jayanta K

2010-10-15

The spacing between ribosome binding site (RBS) and AUG is crucial for efficient overexpression of genes when cloned in prokaryotic expression vectors. We undertook a brief study on the overexpression of genes cloned in Escherichia coli expression vectors, wherein the spacing between the RBS and the start codon was varied. SDS-PAGE and Western blot analysis indicated a high level of protein expression only in constructs where the spacing between RBS and AUG was approximately 40 nucleotides or more, despite the synthesis of the transcripts in the representative cases investigated. Copyright 2010 Elsevier Inc. All rights reserved.

Convergence of third order correlation energy in atoms and molecules.

PubMed

Kahn, Kalju; Granovsky, Alex A; Noga, Jozef

2007-01-30

We have investigated the convergence of third order correlation energy within the hierarchies of correlation consistent basis sets for helium, neon, and water, and for three stationary points of hydrogen peroxide. This analysis confirms that singlet pair energies converge much slower than triplet pair energies. In addition, singlet pair energies with (aug)-cc-pVDZ and (aug)-cc-pVTZ basis sets do not follow a converging trend and energies with three basis sets larger than aug-cc-pVTZ are generally required for reliable extrapolations of third order correlation energies, making so the explicitly correlated R12 calculations preferable.

KSC-08pd2426

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – The large windows of a building at NASA's Kennedy Space Center are covered by plywood and sandbags to protect against the wind and rain driven by Tropical Storm Fay. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.

PubMed

Reshetnyak, Andrey V; Murray, Phillip B; Shi, Xiarong; Mo, Elizabeth S; Mohanty, Jyotidarsini; Tome, Francisco; Bai, Hanwen; Gunel, Murat; Lax, Irit; Schlessinger, Joseph

2015-12-29

Receptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand binding, stimulate a variety of critical cellular functions. The orphan receptor anaplastic lymphoma kinase (ALK) is one of very few RTKs that remain without a firmly established protein ligand. Here we present a novel cytokine, FAM150B, which we propose naming augmentor-α (AUG-α), as a ligand for ALK. AUG-α binds ALK with high affinity and activates ALK in cells with subnanomolar potency. Detailed binding experiments using cells expressing ALK or the related receptor leukocyte tyrosine kinase (LTK) demonstrate that AUG-α binds and robustly activates both ALK and LTK. We show that the previously established LTK ligand FAM150A (AUG-β) is specific for LTK and only weakly binds to ALK. Furthermore, expression of AUG-α stimulates transformation of NIH/3T3 cells expressing ALK, induces IL-3 independent growth of Ba/F3 cells expressing ALK, and is expressed in neuroblastoma, a cancer partly driven by ALK. These experiments reveal the hierarchy and specificity of two cytokines as ligands for ALK and LTK and set the stage for elucidating their roles in development and disease states.

Assay of enterocin AS-48 for inhibition of foodborne pathogens in desserts.

PubMed

Martinez Viedma, Pilar; Abriouel, Hikmate; Ben Omar, Nabil; Lucas López, Rosario; Valdivia, Eva; Gálvez, Antonio

2009-08-01

Enterocin AS-48 was tested against Staphylococcus aureus, Bacillus cereus, and Listeria monocytogenes in different kinds of desserts. The highest activity against S. aureus was detected in baker cream. However, in yogurt-type soy-based desserts and in gelatin pudding, AS-48 (175 arbitrary units [AU]/g) reduced viable cell counts of S. aureus by only 1.5 to 1.8 log units at most. The efficacy of AS-48 in puddings greatly depended on inoculum size, and viable S. aureus counts decreased below detection levels within 24 h for inocula lower than 4 to 5.5 log CFU/g. For L. monocytogenes, bacteriocin concentrations of 52.5 to 87.5 AU/g reduced viable counts below detection levels and avoided regrowth of survivors. The lowest activity was detected in yogurt-type desserts. For B. cereus, viable cell counts were reduced below detection levels for bacteriocin concentrations of 52.5 AU/g in instant pudding without soy or by 175 AU/g in the soy pudding. In gelatin pudding, AS-48 (175 AU/g) reduced viable cell counts of B. cereus below detection levels after 8 h at 10 degrees C or after 48 h at 22 degrees C. Bacteriocin addition also inhibited gelatin liquefaction caused by the proteolytic activity of B. cereus.

Widespread Use of Non-productive Alternative Splice Sites in Saccharomyces cerevisiae

PubMed Central

Kawashima, Tadashi; Douglass, Stephen; Gabunilas, Jason; Pellegrini, Matteo; Chanfreau, Guillaume F.

2014-01-01

Saccharomyces cerevisiae has been used as a model system to investigate the mechanisms of pre-mRNA splicing but only a few examples of alternative splice site usage have been described in this organism. Using RNA-Seq analysis of nonsense-mediated mRNA decay (NMD) mutant strains, we show that many S. cerevisiae intron-containing genes exhibit usage of alternative splice sites, but many transcripts generated by splicing at these sites are non-functional because they introduce premature termination codons, leading to degradation by NMD. Analysis of splicing mutants combined with NMD inactivation revealed the role of specific splicing factors in governing the use of these alternative splice sites and identified novel functions for Prp17p in enhancing the use of branchpoint-proximal upstream 3′ splice sites and for Prp18p in suppressing the usage of a non-canonical AUG 3′-splice site in GCR1. The use of non-productive alternative splice sites can be increased in stress conditions in a promoter-dependent manner, contributing to the down-regulation of genes during stress. These results show that alternative splicing is frequent in S. cerevisiae but masked by RNA degradation and that the use of alternative splice sites in this organism is mostly aimed at controlling transcript levels rather than increasing proteome diversity. PMID:24722551

Maintenance Downtime August 22, 23, 29, 30, 2014

Atmospheric Science Data Center

2014-08-28

... Friday, August 22, 2014 to Saturday, August 23, 2014 Time:  07:00 pm - 08:00 am EDT Event ... on Friday evening through Saturday morning on Aug. 22-23, and again on Aug. 29-30. Periods of intermittent network outages will occur ...

Health Reports.

DTIC Science & Technology

1992-12-01

Atmospheric Nuclear Test Participants Is Flawed (Report, Aug. 10, 1992, GAO/RCED-92-182). Recombinant Bovine Growth Hormone: FDA Approval Should Be Withheld...Until the Mastitis Issue Is Resolved (Report, Aug. 6, 1992, GAO/PEMD-92-26). Women’s Health Information: tHS Lacks an Overall Strategy (Testimony

9 CFR 331.2 - Designation of States under paragraph 301(c) of the Act.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Oct. 1, 1971. Nevada July 1, 1973. New Hampshire Aug. 6, 1978. New Jersey July 1, 1975. New Mexico Aug. 13, 2007. New York July 16, 1975. Northern Mariana Islands Oct. 29, 1979. Oregon July 1, 1972...

9 CFR 381.221 - Designation of States under paragraph 5(c) of the Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... Massachusetts Jan. 12, 1976. Michigan Jan. 2, 1971. Nebraska July 28, 1971. Nevada July 1, 1973. New Hampshire Aug. 6, 1978 New Jersey Do. New Mexico Aug. 13, 2007. New York Apr. 10, 1977. Northern Mariana Islands...

9 CFR 331.2 - Designation of States under paragraph 301(c) of the Act.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Oct. 1, 1971. Nevada July 1, 1973. New Hampshire Aug. 6, 1978. New Jersey July 1, 1975. New Mexico Aug. 13, 2007. New York July 16, 1975. Northern Mariana Islands Oct. 29, 1979. Oregon July 1, 1972...

9 CFR 381.221 - Designation of States under paragraph 5(c) of the Act.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... Massachusetts Jan. 12, 1976. Michigan Jan. 2, 1971. Nebraska July 28, 1971. Nevada July 1, 1973. New Hampshire Aug. 6, 1978 New Jersey Do. New Mexico Aug. 13, 2007. New York Apr. 10, 1977. Northern Mariana Islands...

77 FR 58912 - Designation of One (1) Individual Pursuant to Executive Order 13582 of August 17, 2011, “Blocking...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

...; alt. DOB 31 Aug 1955; alt. DOB 31 Aug 1958; POB Al Basuriyah, Lebanon; alt. POB Beirut, Lebanon; Passport 042833 (Lebanon); Secretary General of HIZBALLAH (individual) [SDT] [SYRIA]. Dated: September 13...

Toxicity of PAMAM-coated gold nanoparticles in different unicellular models.

PubMed

Perreault, François; Melegari, Silvia Pedroso; Fuzinatto, Cristiane Funghetto; Bogdan, Nicoleta; Morin, Mario; Popovic, Radovan; Matias, William Gerson

2014-03-01

Polyamidoamine (PAMAM) dendrimers are used for many pharmaceutical and biomedical applications. However, the toxicological risks of several PAMAM-based compounds are still not fully evaluated, despite evidences of PAMAM deleterious effects on biological membranes, leading to toxicity. In this report, we investigated the toxicity of generation 0 PAMAM-coated gold nanoparticles (AuG0 NPs) in four different models to determine how different cellular systems are affected by PAMAM-coated NPs. Toxicity was evaluated in two mammalian cell lines, Neuro 2A and Vero, in the green alga Chlamydomonas reinhardtii and the bacteria Vibrio fischeri. AuG0 NP treatments reduced cell metabolic activity in algal and bacterial cells, measured by esterase enzymatic activity (C. reinhardtii) and luminescence emission (V. fischeri). EC50 value after 30 min of treatment was similar in both organisms, with 0.114 and 0.167 mg mL(-1) for C. reinhardtii and V. fischeri, respectively. On the other hand, AuG0 NPs induced no change of mitochondrial activity in mammalian cells after 24 h of treatment to up to 0.4 mg mL(-1) AuG0 NPs. Change in the absorption spectra of AuG0 NP in the mammalian cell culture media may indicate an alteration of NP properties that contributed to the low toxicity of AuG0 NPs in mammalian cells. For a safe development of PAMAM-based nanomaterials, the difference of sensitivity between mammalian and microbial cells, as well as the modulation of NPs toxicity by medium properties, should be taken into account when designing PAMAM NPs for applications that may lead to their introduction in the environment. Copyright © 2012 Wiley Periodicals, Inc.

New mechanism for autocatalytic decomposition of H2CO3 in the vapor phase.

PubMed

Ghoshal, Sourav; Hazra, Montu K

2014-04-03

In this article, we present high level ab initio calculations investigating the energetics of a new autocatalytic decomposition mechanism for carbonic acid (H2CO3) in the vapor phase. The calculation have been performed at the MP2 level of theory in conjunction with aug-cc-pVDZ, aug-cc-pVTZ, and 6-311++G(3df,3pd) basis sets as well as at the CCSD(T)/aug-cc-pVTZ level. The present study suggests that this new decomposition mechanism is effectively a near-barrierless process at room temperature and makes vapor phase of H2CO3 unstable even in the absence of water molecules. Our calculation at the MP2/aug-cc-pVTZ level predicts that the effective barrier, defined as the difference between the zero-point vibrational energy (ZPE) corrected energy of the transition state and the total energy of the isolated starting reactants in terms of bimolecular encounters, is nearly zero for the autocatalytic decomposition mechanism. The results at the CCSD(T)/aug-cc-pVTZ level of calculations suggest that the effective barrier, as defined above, is sensitive to some extent to the levels of calculations used, nevertheless, we find that the effective barrier height predicted at the CCSD(T)/aug-cc-pVTZ level is very small or in other words the autocatalytic decomposition mechanism presented in this work is a near-barrierless process as mentioned above. Thus, we suggest that this new autocatalytic decomposition mechanism has to be considered as the primary mechanism for the decomposition of carbonic acid, especially at its source, where the vapor phase concentration of H2CO3 molecules reaches its highest levels.

Hinode Satellite Captures Total Solar Eclipse Video Aug. 21

NASA Image and Video Library

2017-08-21

The Japan Aerospace Exploration Agency, the National Astronomical Observatory of Japan and NASA released this video of Aug. 21 total solar eclipse taken by the X-ray telescope aboard the Hinode joint solar observation satellite as it orbited high above the Pacific Ocean.

93. Neg. No. F78K, Aug 11, 1930, EXTERIORASSEMBLY BUILDING, NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

93. Neg. No. F-78K, Aug 11, 1930, EXTERIOR-ASSEMBLY BUILDING, NORTH SIDE, WITH TAYLOR-TRUCK-A-WAY TRUCKS AND TRAILORS - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

Hydrogen peroxide clusters: the role of open book motif in cage and helical structures.

PubMed

Elango, M; Parthasarathi, R; Subramanian, V; Ramachandran, C N; Sathyamurthy, N

2006-05-18

Hartree-Fock (HF) calculations using 6-31G*, 6-311++G(d,p), aug-cc-pVDZ, and aug-cc-pVTZ basis sets show that hydrogen peroxide molecular clusters tend to form hydrogen-bonded cyclic and cage structures along the lines expected of a molecule which can act as a proton donor as well as an acceptor. These results are reiterated by density functional theoretic (DFT) calculations with B3LYP parametrization and also by second-order Møller-Plesset perturbation (MP2) theory using 6-31G* and 6-311++G(d,p) basis sets. Trends in stabilization energies and geometrical parameters obtained at the HF level using 6-311++G(d,p), aug-cc-pVDZ, and aug-cc-pVTZ basis sets are similar to those obtained from HF/6-31G* calculation. In addition, the HF calculations suggest the formation of stable helical structures for larger clusters, provided the neighbors form an open book structure.

KSC-08pd2425

NASA Image and Video Library

2008-08-21

CAPE CANAVERAL, Fla. – A member of the "ride-out crew," a group of emergency personnel, at NASA's Kennedy Space Center monitors effects from Tropical Storm Fay. In the background is the Operations Support Building I in the Launch Complex 39 Area. The storm passed over the center Aug. 20 and then stalled offshore, bringing with it heavy rain and tropical storm force wind. Kennedy closed Aug. 19 because of Fay and reopened for normal operations Aug. 22. Based on initial assessments, there was no damage to space flight hardware, such as the space shuttles and Hubble Space Telescope equipment. Some facilities did sustain minor damage. Photo credit: NASA/Jack Pfaller

Hazardous-waste-characterization survey of unknown drums at the 21st Tactical Fighter Wing, Elmendorf and Shemya Air Force Bases, and Galena and King Salmon Airports, Alaska. Final report 2-13 Aug 91

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bishop, M.S.

1991-12-01

At the request of the USAF Regional Hospital Elmendorf/SGPB (PACAF), the Armstrong Laboratory, Occupational and Environmental Health Directorate, conducted a hazardous waste characterization survey of unknown drums at Elmendorf AFB from 2 Aug - 13 Aug 91. The scope of the survey was to sample and characterize drums of unknown material stored at Elmendorf AFB, Shemya AFB, and Galena and King Salmon Airports. Several waste streams were sampled at Elmendorf AFB to revalidate sample results from a previous survey.

Russian Space Suits ready

NASA Image and Video Library

2014-08-17

ISS040-E-095609 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.

Russian Space Suits ready

NASA Image and Video Library

2014-08-17

ISS040-E-095619 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.

Russian Space Suits ready

NASA Image and Video Library

2014-08-17

ISS040-E-095615 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.

Russian Space Suits ready

NASA Image and Video Library

2014-08-17

ISS040-E-095617 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.

Russian Space Suits ready

NASA Image and Video Library

2014-08-17

ISS040-E-095612 (17 Aug. 2014) --- Unoccupied Russian Orlan spacesuits for Russian cosmonauts Oleg Artemyev (blue stripes) and Alexander Skvortsov (red stripes), both Expedition 40 flight engineers, are pictured in the Pirs Docking Compartment of the International Space Station on the eve of the spacewalk scheduled for Aug. 18, 2014.

Earth observation taken by the Expedition 28 crew

NASA Image and Video Library

2011-08-24

ISS028-E-031904 (24 Aug. 2011) --- This photo of Hurricane Irene was photographed from onboard the International Space station at 19:14:14 GMT on Aug. 24, 20ll. The image, captured with the aid of a 70?mm lens, reveals the eye at center frame.

Fermilab Today

Science.gov Websites

registration due today Women's Initiative: "Guiltless: Work/Life Balance" - Aug. 13 Nominations for ; -Leah Hesla In Brief Women's Initiative presents 'Guiltless: Work-Life Balance' - Thursday in One West Cowperthwaite-O'Hagan present "Guiltless: Work-Life Balance" on Thursday, Aug. 13, at 3 p.m. in One

Why Photonic Systems for Space?

DTIC Science & Technology

2006-08-01

AUG 2006 Conference Paper Postprint Oct 98 - Aug 00 WHY PHOTONIC SYSTEMS FOR SPACE? In-House 62204F LINK SN 01 Norman Bernstein, George Brost ...Invited Paper Why photonic systems for space? Norman P. Bernstein*, George A. Rrost. Michael J. Hayduk. James R. Hunter, James E. Nichter, Paul M

78 FR 45460 - Suspension of Community Eligibility

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... County 515520 July 24, 1970, Aug. 19, 2013......... Aug. 19, 2013. Emerg; December 31, 1976, Reg; August..., 1981, Reg; August 19, 2013, Susp. Chippewa Lake, Village of, 390910 February 24, ......do Do. Medina..., 2013, Susp. Dubuque County, 190534 May 24, 1974, ......do Do. Unincorporated Areas. Emerg; September 1...

Further spectroscopy of the 2017 outburst of PT And

NASA Astrophysics Data System (ADS)

Williams, S. C.; Darnley, M. J.

2017-09-01

We obtained our first spectrum of the 2017 outburst of PT And (AT 2017gay) on 2017 Aug 17.05 UT and reported the results in ATel #10647. Another spectrum, taken 2017 Aug 24.16 with the Nordic Optical Telescope was reported by ATel #10672.

New NASA Maps Show Flooding Changes In Aftermath of Hurricane Harvey

NASA Image and Video Library

2017-09-13

Data from NASA's Soil Moisture Active Passive (SMAP) satellite have been used to create new surface flooding maps of Southeast Texas and the Tennessee Valley following Hurricane Harvey. The SMAP observations detect the proportional cover of surface water within the satellite sensor's field of view. This sequence of images shows changes in the extent of surface flooding from successive five-day SMAP observation composite images. Widespread flooding can be seen in the Houston metropolitan area on Aug. 27 following record rainfall from the Category 4 hurricane, which made landfall on Aug. 25th, 2017 (left image). Flood waters around Houston had substantially receded by Aug. 31 (middle image), while flooding had increased across Louisiana, eastern Arkansas, and western Tennessee as then Tropical Storm Harvey passed over the area. The far right image shows the change in flooded area between Aug. 27 and Aug. 31, with regions showing the most flooding recession depicted in yellow and orange shades and those where flooding had increased depicted in blue shades. The SMAP satellite has a low-frequency (L-band) microwave radiometer with enhanced capabilities for detecting surface water changes in nearly all weather conditions and under low-to-moderate vegetation cover. SMAP provides global coverage with one-to-three-day repeat sampling that is well suited for global monitoring of inland surface water cover dynamics. https://photojournal.jpl.nasa.gov/catalog/PIA21951

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

47 CFR 64.607 - Furnishing related customer premises equipment.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... 64.607 Section 64.607 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... premises equipment. (a) Any communications common carrier may provide, under tariff, customer premises... computers. [56 FR 36731, Aug. 1, 1991, as amended at 72 FR 43560, Aug. 6, 2007; 73 FR 21252, Apr. 21, 2008...

50 CFR 648.23 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... mesh, inside stretch measure, applied throughout the codend for at least 100 continuous meshes forward... (Sept-Dec), or 17/8 inches (48 mm), during Trimester II (May-Aug), diamond mesh, inside stretch measure...), during Trimester II (May-Aug), diamond mesh, inside stretch measure. “Top of the regulated portion of the...

Pursuit of Precision in the Field Artillery

DTIC Science & Technology

2010-05-21

convention banning cluster bombs will enter into force on Aug.,” Huffingtonpost , http://www.huffingtonpost.com/2010/02/17/un-ratifies-ban-on...banning cluster bombs will enter into force on Aug.” Huffingtonpost . http://www.huffingtonpost.com/2010/02/17/un-ratifies-ban-on- cluste_n_465022.html

78 FR 6362 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

.... 23958 (Aug. 20, 1999) (64 FR 46821 (Aug. 27, 1999)). \\3\\ Investment Adviser Codes of Ethics, Investment... adviser or principal underwriter (each a ``17j-1 organization''), in connection with the purchase or sale..., deceptive, or manipulative act or practice in contravention of the Commission's rules and regulations...

75 FR 5152 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

.... 23958 (Aug. 20, 1999) (64 FR 46821-01 (Aug. 27, 1999)). \\3\\ Investment Adviser Codes of Ethics... investment adviser or principal underwriter (each a ``17j-1 organization''), in connection with the purchase..., deceptive, or manipulative act or practice in contravention of the Commission's rules and regulations...

78 FR 53007 - Additional Designations, Foreign Narcotics Kingpin Designation Act

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-27

... MORALES, Jairo Estuardo (a.k.a. ``EL PELON''), Aldea Dona Maria, Zacapa, Guatemala; DOB 28 Sep 1973; POB Zacapa, Guatemala; nationality Guatemala; citizen Guatemala; Cedula No. R-19 42080 (Guatemala); Passport 111904000420805 (Guatemala) issued 28 Aug 2008 expires 28 Aug 2013 (individual) [SDNTK]. Dated: August 20, 2013...

Detection, Classification, and Localization Workshop 2011

DTIC Science & Technology

2011-09-30

held at Mt. Hood’s Timberline Lodge from Aug. 22-25, 2011 (Monday - Thursday), with a preceding day (Sunday Aug. 21) devoted to tutorials. This site...meals, because it keeps attendees together and encourages mixing. (5) Ensure there is enough lodging in the area, with a variety of price/quality

Earth Observation

NASA Image and Video Library

2014-08-10

ISS040-E-091158 (10 Aug. 2014) --- One of the Expedition 40 crew members 225 nautical miles above Earth onboard the International Space Station used a 200mm lens to record this image of Hawke's Bay, New Zealand on Aug. 10, 2014. Napier and the bay area's most populous area are at bottom center of the frame.

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2011 CFR

2011-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2014 CFR

2014-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2013 CFR

2013-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

42 CFR 60.14 - The insurance premium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... one-time special charge with no subsequent adjustments required. The lender may bill the borrower... premium through a notice published in the Federal Register. (c) Method of calculation—(1) Student... calculated for each disbursement. [48 FR 38988, Aug. 26, 1983, as amended at 51 FR 30644 Aug. 28, 1986; 52 FR...

Translations on North Korea, Number 552

DTIC Science & Technology

1977-09-19

KCNA in English 0337 GMT 31 Aug 77 SK] ECUADOREAN PUBLISHER LEAVES—Pyongyang, 29 August—Humberto Ortiz Flores, director of the " Voluntad " publishing...steady rise.[Pyongyang KCNA in English 1530 GMT 26 Aug 77 OW] ECUADOR PUBLISHER—Humberto Ortiz Flores, director of the " Voluntad " publishing house

Au-Ge MEAM potential fitted to the binary phase diagram

NASA Astrophysics Data System (ADS)

Wang, Yanming; Santana, Adriano; Cai, Wei

2017-02-01

We have developed a modified embedded atom method potential for the gold-germanium (Au-Ge) binary system that is fitted to the experimental binary phase diagram. The phase diagram is obtained from the common tangent construction of the free energy curves calculated by the adiabatic switching method. While maintaining the accuracy of the melting points of pure Au and Ge, this potential reproduces the eutectic temperature, eutectic composition and the solubility of Ge in solid Au, all in good agreement with the experimental values. To demonstrate the self-consistency of the potential, we performed benchmark molecular dynamics simulations of Ge crystal growth and etching in contact with a Au-Ge liquid alloy.

Contribution of photosynthesized carbon to the methane emitted from paddy fields

NASA Astrophysics Data System (ADS)

Minoda, T.; Kimura, M.

1994-09-01

Emission rates of CH4 from paddy soil with and without rice straw applications were measured with pot experiments to estimate the contribution of rice straw to total CH4 emissions during the growing season. The CH4 derived from rice straw was calculated to be 50.4% of the total emission. 13CO2 uptake experiments were carried out three times from Aug. 8 to Sept. 18 to estimate the contribution of photosynthesized carbon to CH4 emission. The contribution percentages of photosynthesized carbon to the total CH4 emitted to the atmosphere were 72-110% around Aug. 8, 29-36% around Aug. 30, and 13-17% around Sept. 18, 1993.

Earth Observation

NASA Image and Video Library

2014-08-01

ISS040-E-87351 (1 Aug. 2014) --- This sunset shot, photographed by an Expedition 40 crew member on the International Space Station, shows polar mesospheric clouds only as a thin bright line ? far above the lowest, yellow-brown weather layer of the atmosphere (known as the troposphere) when the space station was flying over southern Ukraine on Aug. 1, 2014.

Persian Gulf Contrail Altitude Limits

DTIC Science & Technology

1991-06-01

71000 APR 5500 32800 50200 68500 MAT 25000 34800 50600 73500 JUN 31500 43400 57400 84500 JUL 39500 45200 50800 70500 AUG 35000 44200 58800 81500 SEP 33500...47900 65000 HAT 30500 38200 49900 61000 Jui3~4500 44200 54600 69500 JUL 18500 45100 51600 67000 AUG3 39000 M4300 54500 69500 SEP 34500 43500 53900

Nanophotonic Devices - Spontaneous Emission Faster than Stimulated Emission

DTIC Science & Technology

2014-11-04

2010 Granada Spain PECS IX "The Two Conflicting Narratives of Metal-Optics" Aug. 17, 2010 Seoul Korea IEEE Nano Korea Symposium "The Two...Two Conflicting Narratives of Metal-Optics" Sept. 28, 2010 Granada Spain PECS IX "The Two Conflicting Narratives of Metal-Optics" Aug. 17, 2010

Earth Observation

NASA Image and Video Library

2013-08-29

ISS036-E-038117 (29 Aug. 2013) --- One of the Expedition 36 crew members aboard the Earth-orbiting International Space Station photographed massive smoke plumes from the California wildfires. When this image was exposed on Aug. 29, the orbital outpost was approximately 220 miles above a point located at 38.6 degrees north latitude and 123.2 degrees west longitude.

Earth Observation

NASA Image and Video Library

2013-08-29

ISS036-E-038114 (29 Aug. 2013) --- One of the Expedition 36 crew members aboard the Earth-orbiting International Space Station photographed massive smoke plumes from the California wildfires. When this image was exposed on Aug. 29, the orbital outpost was approximately 220 miles above a point located at 38.6 degrees north latitude and 123.3 degrees west longitude.

Skylab 3, Owen K. Garriott on EVA

NASA Image and Video Library

2009-01-15

SL3-122-2610 (6 Aug. 1973) --- Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, looks at the camera as he participates in the Aug. 6, 1973 extravehicular activity (EVA) during which he and astronaut Jack R. Lousma, pilot, deployed the twin pole solar shield to help shade the Orbital Workshop (OWS). Photo credit: NASA

Hatch Opening OPS

NASA Image and Video Library

2009-08-31

S128-E-007009 (30 Aug. 2009) --- Astronaut Patrick Forrester, STS-128 mission specialist, prepares to open the hatch that will lead the entire Space Shuttle Discovery crew into the International Space Station. The two spacecraft docked at 7:54 p.m. (CDT), and the Discovery crew entered the orbital outpost at 9:59 p.m. (CDT) on Aug. 30.

Skylab 3, Owen K. Garriott on EVA

NASA Image and Video Library

1973-08-06

SL3-122-2609 (6 Aug. 1973) --- Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, looks at the camera as he participates in the Aug. 6, 1973 extravehicular activity (EVA) during which he and astronaut Jack R. Lousma, pilot, deployed the twin pole solar shield to help shade the Orbital Workshop (OWS). Photo credit: NASA

Targeted, On-Demand Charge Conversional Nanotherapeutics for Advanced Prostate Cancer

DTIC Science & Technology

2015-09-01

Figure 3 . The fluorescent activated cell sorting (FACS) analysis of cellular uptake of Cy5.5 loaded Pep -PEG-PTMC nanoparticles after incubation with...PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE September 2015 2. REPORT TYPE Annual 3 . DATES COVERED 29 Aug 2014 – 28 Aug...

Alternative Fuels Data Center: North Carolina Transportation Data for

Science.gov Websites

) 2,115 Source: BioFuels Atlas from the National Renewable Energy Laboratory Case Studies Video thumbnail CNG Installation a Boost Aug. 19, 2015 Video thumbnail for Biodiesel Offers an Easy Alternative for Fleets Biodiesel Offers an Easy Alternative for Fleets Aug. 18, 2015 Video thumbnail for Blue Skies

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Piper Van Wagenen, one of Neil Armstrong's 10 grandchildren, speaks during a memorial service celebrating the life of her grandfather, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

U.S. Sen. Rob Portman, R-Ohio, speaks during a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Sen. John Glenn and his wife Annie listen during a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Eric "Rick" Armstrong, son of Neil Armstrong, speaks during a memorial service celebrating the life of his father, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Neil Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

A memorial tribute from the Smithsonian is seen at the entrance of a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Apollo 11 Astronauts Michael Collins, left, and Buzz Aldrin talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

The Hamilton Co. (OH) Sheriff’s Office bagpipe corps concludes the memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Businessman and friend of Neil Armstrong, Charles Mechem, speaks during a memorial service celebrating the life of Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Mark Armstrong, son of Neil Armstrong, speaks during a memorial service celebrating the life of his father, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Neil Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

30 CFR 780.14 - Operation plan: Maps and plans.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., and non-coal waste storage area; (6) Each water diversion, collection, conveyance, treatment, storage... water impoundment, refuse pile, and coal mine waste impoundment for which plans are required by § 780.25... architecture. [44 FR 15357, Mar. 13, 1979; 44 FR 49685, Aug. 24, 1979, as amended at 45 FR 51550, Aug. 4, 1980...

27 CFR 555.202 - Classes of explosive materials.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., except for bulk salutes). (c) Blasting agents. (For example, ammonium nitrate-fuel oil and certain water-gels (see also § 555.11). [T.D. ATF-87, 46 FR 40384, Aug. 7, 1981, as amended by T.D. ATF-293, 55 FR 3722, Feb. 5, 1990; T.D. ATF-400, 63 FR 45003, Aug. 24, 1998] ...

Augmented neural networks and problem structure-based heuristics for the bin-packing problem

NASA Astrophysics Data System (ADS)

Kasap, Nihat; Agarwal, Anurag

2012-08-01

In this article, we report on a research project where we applied augmented-neural-networks (AugNNs) approach for solving the classical bin-packing problem (BPP). AugNN is a metaheuristic that combines a priority rule heuristic with the iterative search approach of neural networks to generate good solutions fast. This is the first time this approach has been applied to the BPP. We also propose a decomposition approach for solving harder BPP, in which subproblems are solved using a combination of AugNN approach and heuristics that exploit the problem structure. We discuss the characteristics of problems on which such problem structure-based heuristics could be applied. We empirically show the effectiveness of the AugNN and the decomposition approach on many benchmark problems in the literature. For the 1210 benchmark problems tested, 917 problems were solved to optimality and the average gap between the obtained solution and the upper bound for all the problems was reduced to under 0.66% and computation time averaged below 33 s per problem. We also discuss the computational complexity of our approach.

Achieving effective universal health coverage with equity: evidence from Chile.

PubMed

Frenz, Patricia; Delgado, Iris; Kaufman, Jay S; Harper, Sam

2014-09-01

Chile's 'health guarantees' approach to providing universal and equitable coverage for quality healthcare in a dual public-private health system has generated global interest. The programme, called AUGE, defines legally enforceable rights to explicit healthcare benefits for priority health conditions, which incrementally covered 56 problems representing 75% of the disease burden between 2005 and 2009. It was accompanied by other health reform measures to increase public financing and public sector planning to secure the guarantees nationwide, as well as the state's stewardship role. We analysed data from household surveys conducted before and after the AUGE reform to estimate changes in levels of unmet health need, defined as the lack of a healthcare visit for a health problem occurring in the last 30 days, by age, sex, income, education, health insurance, residence and ethnicity; fitting logistic regression models and using predictive margins. The overall prevalence of unmet health need was much lower in 2009 (17.6%, 95% CI: 16.5%, 18.6%) than in 2000 (30.0%, 95% CI: 28.3%, 31.7%). Differences by income and education extremes and rural-urban residence disappeared. In 2009, people who had been in treatment for a condition covered by AUGE in the past year had a lower adjusted prevalence of unmet need for their recent problem (11.7%, 95% CI: 10.5%, 13.2%) than who had not (21.0%, 95% CI: 19.6%, 22.4%). Despite limitations including cross-sectional and self-reported data, our findings suggest that the Chilean health system has become more equitable and responsive to need. While these changes cannot be directly attributed to AUGE, they were coincident with the AUGE reforms. However, healthcare equity concerns are still present, relating to quality of care, health system barriers and differential access for health conditions that are not covered by AUGE. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine © The Author 2013; all rights reserved.

Antibiotic resistant salmonella and Escherichia coli isolated from indigenous Gallus domesticus in Nairobi, Kenya.

PubMed

Wesonga, S M; Muluvi, G M; Okemo, P O; Kariuki, S

2010-05-01

To characterise and investigate antimicrobial resistance of Esherichia coli and salmonella strains isolated from indigenous Gallus gallus in a leading slaughterhouse/market outlet in Nairobi-Kenya. A repeated cross sectional study and based on random sampling was used. The study was carried out in a leading market outlet in Nairobi, Kenya. A hundred and four indigenous chicken rectal swabs were analysed, of which 67.3% were contaminated with Escherichia coli and 12.5% with Salmonella typhimurium. Seventy Escherichia coli isolates showed resistance phenotypes to one, two or more antibiotics. The most common antimicrobial resistance pattern was the single resistance to Tet (21.43%), followed by Amp Cot Tet (14%), Aug Amp Cot Tet (4.29%), Aug Amp Cot Tet Kan Chl (2.86%), Amp Cot Tet Chl, Cot Tet (2.86%) and Crx Amp Cot Tet Chl, Crx Amp Cot Chi, Amp Cot, Aug Amp, (1.43%) respectively. The highest rate of resistance was against Tet (55.7%), followed by Cot (40%). Third in line of resistance was Amp 32.86%, followed by Aug (11.43%), low or moderate resistance was against Chl (8.57%), Kan (4.29%), and Crx (2.86%) (P<0.0002). Salmonella typhimurium recovered displayed single resistance pattern to Tet (16.67%), Gen Cot Tet (8.33%), Amp Cot Tet (8.33%), Aug Amp Cot Tet (8.33%) and Amp Cot Tet Chl (16.67%). The highest resistance was against Tet (58.3%), Cot (41.7%), Amp (33.3%), Chl (16.7%), Aug and Gen (8.3%) respectively (P<0.0001). 3.0kb and 5.6kb plasmids isolated were not transferable by conjugation. Routine surveillance at slaughter/market outlets of Escherichia coli and Salmonella enterica should be done to identify infected flocks as a regulatory procedure for food safety and security programme.

Interaction of ICRF Fields with the Plasma Boundary in AUG and JET and Guidelines for Antenna Optimization

NASA Astrophysics Data System (ADS)

Bobkov, V.; Bilato, R.; Braun, F.; Colas, L.; Dux, R.; Van Eester, D.; Giannone, L.; Goniche, M.; Herrmann, A.; Jacquet, P.; Kallenbach, A.; Krivska, A.; Lerche, E.; Mayoral, M.-L.; Milanesio, D.; Monakhov, I.; Müller, H. W.; Neu, R.; Noterdaeme, J.-M.; Pütterich, Th.; Rohde, V.

2009-11-01

W sputtering during ICRF on ASDEX Upgrade (AUG) and temperature rise on JET A2 antenna septa are considered in connection with plasma conditions at the antenna plasma facing components and E‖ near-fields. Large antenna-plasma clearance, high gas puff and low light impurity content are favorable to reduce W sputtering in AUG. The spatial distribution of spectroscopically measured effective W sputtering yields clearly points to the existence of strong E‖ fields at the antenna box ("feeder fields") which dominate over the fields in front of the antenna straps. The picture of E‖ fields, obtained by HFSS code, corroborates the dominant role of E‖ at the antenna box on the formation of sheath-driving RF voltages for AUG. Large antenna-plasma clearance and low gas puff are favorable to reduce septum temperature of JET A2 antennas. Assuming a linear relation between the septum temperature and the sheath driving RF voltage calculated by HFSS, the changes of the temperature with dipole phasing (00ππ, 0ππ0 or 0π0π) are well described by the related changes of the RF voltages. Similarly to the AUG antenna, the strongest E‖ are found at the limiters of the JET A2 antenna for all used dipole phasings and at the septum for the phasings different from 0π0π. A simple general rule can be used to minimize E‖ at the antenna: image currents can be allowed only at the surfaces which do not intersect magnetic field lines at large angles of incidence. Possible antenna modifications generally rely either on a reduction of the image currents, on their short-circuiting by introducing additional conducting surfaces or on imposing the E‖ = 0 boundary condition. On the example of AUG antenna, possible options to minimize the sheath driving voltages are presented.

What Caused the August 2002 Catastrophic Floods in Central Europe?

NASA Technical Reports Server (NTRS)

Otterman, J.; Atlas, R.; Jusem, J. C.; Van Engelen, A.; Terry, J.

2002-01-01

The catastrophic August 2002 floods in central Europe followed very intense rains over a span of several days, reported over a large region. On Aug. 12 meteorological stations over an elongated swath, from the vicinity of Saltzburg (Austria) in the south to the vicinity of Berlin in the north, reported precipitation exceeding 100 mm/day. Synoptic analysis points to a jet streak in the mid-Atlantic. moving eastward, which reached Spain on about 9th of August. An understanding of the mechanism that ultimately produced the unprecedented rains was derived conveniently from the GEOS 3 Model developed at NASA Goddard Space Flight Center. Examining the scenarios of omega, we observe on Aug. 10, OOZ, a center of ascending vertical motions, stronger than 0.6 Pa/s at the 700 hPa level over the western Mediterranean. Advecting moist and warm air to higher levels from the near-ocean level, the center moved eastward, reaching the northern Adriatic on Aug. 11, OOZ, then continuing northeast to the regions where most intense precipitation was reported on Aug. 12. The omega at 850 hPa shows a closely similar pattern but especially interesting is the 850 omega pattern on Aug. 12, 12Z, which shows descending motions stronger than 0.4 Pa/s over the eastern Po Valley (northern Italy), and an elongated region of ascending motions stronger than 1.0 Pa/s coinciding in extent with the extreme-precipitation region on that day. At that time, the cyclone which formed over the Po Valley, was centered on eastern Czech Republic, producing on its western side these strong ascending motions over the precipitation region. The pattern of the surface-pressure lows provides further insight into the processes, and specifically, the Aug. 12,06Z map, shows a 996 mb low over the western Czech Republic. The flooding following the extreme rains was acerbated by the fact that river-channels were made narrower over the recent decades by the urbanization of river banks.

Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients ‘on’ or ‘off’ augmentation therapy

PubMed Central

2014-01-01

Background There is still limited information on systemic inflammation in alpha-1-antitrypsin-deficient (AATD) COPD patients and what effect alpha-1-antitrypsin augmentation therapy and/or exercise might have on circulating inflammatory cytokines. We hypothesized that AATD COPD patients on augmentation therapy (AATD + AUG) would have lower circulating and skeletal muscle inflammatory cytokines compared to AATD COPD patients not receiving augmentation therapy (AATD-AUG) and/or the typical non-AATD (COPD) patient. We also hypothesized that cytokine response to exercise would be lower in AATD + AUG compared to AATD-AUG or COPD subjects. Methods Arterial and femoral venous concentration and skeletal muscle expression of TNFα, IL-6, IL-1β and CRP were measured at rest, during and up to 4-hours after 50% maximal 1-hour knee extensor exercise in all COPD patient groups, including 2 additional groups (i.e. AATD with normal lung function, and healthy age-/activity-matched controls). Results Circulating CRP was higher in AATD + AUG (4.7 ± 1.6 mg/dL) and AATD-AUG (3.3 ± 1.2 mg/dL) compared to healthy controls (1.5 ± 0.3 mg/dL, p < 0.05), but lower in AATD compared to non-AATD-COPD patients (6.1 ± 2.6 mg/dL, p < 0.05). TNFα, IL-6 and IL-1β were significantly increased by 1.7-, 1.7-, and 4.7-fold, respectively, in non-AATD COPD compared to AATD COPD (p < 0.05), and 1.3-, 1.7-, and 2.2-fold, respectively, compared to healthy subjects (p < 0.05). Skeletal muscle TNFα was on average 3–4 fold greater in AATD-AUG compared to the other groups (p < 0.05). Exercise showed no effect on these cytokines in any of our patient groups. Conclusion These data show that AATD COPD patients do not experience the same chronic systemic inflammation and exhibit reduced inflammation compared to non-AATD COPD patients. Augmentation therapy may help to improve muscle efflux of TNFα and reduce muscle TNFα concentration, but showed no effect on IL-6, IL-1β or CRP. PMID:24975928

7 CFR 3015.1 - Purpose and scope of this part.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER... material for this part and in keeping it up-to-date is delegated to the Office of the Chief Financial Officer. [46 FR 55639, Nov. 10, 1981, as amended at 62 FR 45949, Aug. 29, 1997; 65 FR 49479, Aug. 14, 2000] ...

Virtual Mentor Cataract Surgery Trainer

DTIC Science & Technology

2009-09-01

excessive lens movement), look for zonular absence, assess for notable lenticular astigmatism ** How and when do you decide to use a capsular...AD_________________ AWARD NUMBER: W81XWH-08-1-0531 TITLE: Virtual Mentor Cataract Surgery Trainer...REPORT TYPE Annual 3. DATES COVERED 20 Aug 2008 – 19 Aug 2009 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Virtual Mentor Cataract Surgery

Regulations governing the issuance of certificates of airworthiness of aircraft in France

NASA Technical Reports Server (NTRS)

1923-01-01

These regulations, approved by the Under Secretary of State for Aeronautics, in a ministerial decree 1124/2a, Feb. 19, 1923, cancels the regulations of Aug. 31, 1920, and supplements the decree of Aug. 14, 1920, fixing the conditions under which certificates of airworthiness may be issued,in conformity with Article 5 of said decree.

48 CFR 1052.234-71 - Notice of Earned Value Management System-Post-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2012 CFR

2012-10-01

... Management System-Post-Award IBR (Core) AUG 2011 1052.234-71 Section 1052.234-71 Federal Acquisition... Texts of Provisions and Clauses 1052.234-71 Notice of Earned Value Management System—Post-Award IBR... require the contractor to use an earned value management system (EVMS) and for which the Government...

48 CFR 1052.234-71 - Notice of Earned Value Management System-Post-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2013 CFR

2013-10-01

... Management System-Post-Award IBR (Core) AUG 2011 1052.234-71 Section 1052.234-71 Federal Acquisition... Texts of Provisions and Clauses 1052.234-71 Notice of Earned Value Management System—Post-Award IBR... require the contractor to use an earned value management system (EVMS) and for which the Government...

48 CFR 1052.234-71 - Notice of Earned Value Management System-Post-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2014 CFR

2014-10-01

... Management System-Post-Award IBR (Core) AUG 2011 1052.234-71 Section 1052.234-71 Federal Acquisition... Texts of Provisions and Clauses 1052.234-71 Notice of Earned Value Management System—Post-Award IBR... require the contractor to use an earned value management system (EVMS) and for which the Government...

Alternative Fuels Data Center: Phoenix Utility Fleet Drives Smarter with

Science.gov Websites

electric car. College Students Engineer Efficient Vehicles in EcoCAR 2 Competition Aug. 2, 2014 Photo of a BiodieselA> Phoenix Utility Fleet Drives Smarter with Biodiesel to someone by E-mail Share ... Aug. 26, 2017 Phoenix Utility Fleet Drives Smarter with Biodiesel Watch how a utility company in

Alternative Fuels Data Center: New York City Cleans up With Alternative

Science.gov Websites

uses natural gas, biodiesel, and hybrid electric trucks. For information about this project, contact Fleet Drives Smarter with Biodiesel Aug. 26, 2017 Photo of a car Idaho Surges Ahead with Electric Vehicle Charging Aug. 4, 2017 Photo of a truck Cooking Oil Powers Biodiesel Vehicles in Rhode Island July

48 CFR 1052.234-71 - Notice of Earned Value Management System-Post-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2011 CFR

2011-10-01

... Management System-Post-Award IBR (Core) AUG 2011 1052.234-71 Section 1052.234-71 Federal Acquisition... Texts of Provisions and Clauses 1052.234-71 Notice of Earned Value Management System—Post-Award IBR... require the contractor to use an earned value management system (EVMS) and for which the Government...

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

A photograph of Neil Armstrong as a young man is displayed on a table during a memorial service celebrating the life of Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Piper Van Wagenen, one of Neil Armstrong's 10 grandchildren, is seen during preparation of a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

View of coronal hole processed from television transmission of ATM

NASA Image and Video Library

1973-08-20

S73-32883 (20 Aug. 1973) --- This false color isophote, processed from an Aug. 20, 1973 television transmission of Apollo Telescope Mount (ATM) experiments from Skylab 3, dramatically reveals a significant change in the coronal hole as compared to the previous day. Solar rotation accounts for the new location of the coronal hole. Photo credit: NASA

Remedial Investigation for Cold Regions Research and Engineering Laboratory (CRREL) Hanover, New Hampshire. Phase 2. Volume 3. Appendices. Revision 2

DTIC Science & Technology

1994-03-18

93 6-Aug-943 U1421 STYR tOOL 5.0c :0SS33 MIST044 ;AOI.905 AZ;ýI A -Aug-9 3 R-Auq-93 01121 .S’YR Uý 5.3( 1,:5337 91ST046 JA02194 ADYR Rt 20-Aug-93 25...Zffe-t-s E’ac-ilitY at sam-1v locaticns 378, 379, and 382. i three point azmm1y of learne icai i~taiuity wa also icdertifiaeucd ~ s of the L09st-IcS and...Retrieval operations are dependent of surface comxtiaw and rcetinely (xxsist of the folloiwhg tw metho. 2e first methd applies to grass covered or

Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buggiano, Valeria; Petrillo, Ezequiel; Alló, Mariano

2015-07-15

Alternative pre-mRNA splicing plays key roles in determining tissue- and species-specific cell differentiation as well as in the onset of hereditary disease and cancer, being controlled by multiple post- and co-transcriptional regulatory mechanisms. We report here that airborne particulate matter, resulting from industrial pollution, inhibits expression and specifically affects alternative splicing at the 5′ untranslated region of the mRNA encoding the bone morphogenetic protein BMP4 in human colon cells in culture. These effects are consistent with a previously reported role for BMP4 in preventing colon cancer development, suggesting that ingestion of particulate matter could contribute to the onset of colonmore » cell proliferation. We also show that the underlying mechanism might involve changes in transcriptional elongation. This is the first study to demonstrate that particulate matter causes non-pleiotropic changes in alternative splicing. - Highlights: • Airborne particulate matter (PM10) affects alternative splicing in colon cells. • PM10 upregulates one of the two mRNA variants of the growth factor BMP-4. • This variant has a longer 5′ unstranslated region and introduces an upstream AUG. • By regulating BMP-4 mRNA splicing PM10 inhibits total expression of BMP-4 protein. • BMP-4 downregulation was previously reported to be associated to colon cancer.« less

The human insulin receptor mRNA contains a functional internal ribosome entry segment

PubMed Central

Spriggs, Keith A.; Cobbold, Laura C.; Ridley, Simon H.; Coldwell, Mark; Bottley, Andrew; Bushell, Martin; Willis, Anne E.; Siddle, Kenneth

2009-01-01

Regulation of mRNA translation is an important mechanism determining the level of expression of proteins in eukaryotic cells. Translation is most commonly initiated by cap-dependent scanning, but many eukaryotic mRNAs contain internal ribosome entry segments (IRESs), providing an alternative means of initiation capable of independent regulation. Here, we show by using dicistronic luciferase reporter vectors that the 5′-UTR of the mRNA encoding human insulin receptor (hIR) contains a functional IRES. RNAi-mediated knockdown showed that the protein PTB was required for maximum IRES activity. Electrophoretic mobility shift assays confirmed that PTB1, PTB2 and nPTB, but not unr or PTB4, bound to hIR mRNA, and deletion mapping implicated a CCU motif 448 nt upstream of the initiator AUG in PTB binding. The IR-IRES was functional in a number of cell lines, and most active in cells of neuronal origin, as assessed by luciferase reporter assays. The IRES was more active in confluent than sub-confluent cells, but activity did not change during differentiation of 3T3-L1 fibroblasts to adipocytes. IRES activity was stimulated by insulin in sub-confluent cells. The IRES may function to maintain expression of IR protein in tissues such as the brain where mRNA translation by cap-dependent scanning is less effective. PMID:19654240

HSF and Msn2/4p can exclusively or cooperatively activate the yeast HSP104 gene.

PubMed

Grably, Melanie R; Stanhill, Ariel; Tell, Osnat; Engelberg, David

2002-04-01

In an effort to understand how an accurate level of stress-specific expression is obtained, we studied the promoter of the yeast HSP104 gene. Through 5' deletions, we defined a 334 bp fragment upstream of the first coding AUG as sufficient and essential for maximal basal activity and a 260 bp fragment as sufficient and essential for heat shock responsiveness. These sequences contain heat shock elements (HSEs) and stress response elements (STREs) that cooperate to achieve maximal inducible expression. However, in the absence of one set of factors (e.g. in msn2Deltamsn4Delta cells) proper induction is obtained exclusively through HSEs. We also show that HSP104 is constitutively derepressed in ras2Delta cells. This derepression is achieved exclusively through activation of STREs, with no role for HSEs. Strikingly, in ras2Deltamsn2Deltamsn4Delta cells the HSP104 promoter is also derepressed, but in this strain derepression is mediated through HSEs, showing the flexibility and adaptation of the promoter. Thus, appropriate transcription of HSP104 is usually obtained through cooperation between the Msn2/4/STRE and the HSF/ HSE systems, but each factor could activate the promoter alone, backing up the other. Transcription control of HSP104 is adaptive and robust, ensuring proper expression under extreme conditions and in various mutants.

[The regulation of peroxisomal matrix enzymes (alcohol oxidase and catalase) formation by the product of the gene Mth1 in methylotrophic yeast Pichia methanolica].

PubMed

Leonovich, O A; Kurales, Iu A; Dutova, T A; Isakova, E P; Deriabina, Iu I; Rabinovich, Ia M

2009-01-01

Two independent mutant strains of methylotrophic yeast Pichia methanolica (mth1 arg1 and mth2 arg4) from the initial line 616 (ade1 ade5) were investigated. The mutant strains possessed defects in genes MTH1 and MTH2 which resulted in the inability to assimilate methanol as a sole carbon source and the increased activity of alcohol oxidase (AO). The function of the AUG2 gene encoding one of the subunits of AO and CTA1, a probable homolog of peroxisomal catalase of Saccharomyces cereviseae, was investigated by analyses of the molecular forms of isoenzymes. It was shown that optimal conditions for the expression of the AUG2 gene on a medium supplemented with 3% of methanol leads to an increasing synthesis of peroxisomal catalase. The mutant mth1 possessed a dominant formation of AO isoform with electrophoretic mobility which is typical for isogenic form 9, the product of the AUG2 gene, and a decreased level of peroxisomal catalase. The restoration of growth of four spontaneous revertants of the mutant mth1 (Rmth1) on the methanol containing medium was accompanied by an increase in activity of AO isogenic form 9 and peroxisomal catalase. The obtained results confirmed the functional continuity of the structural gene AUG2 in mutant mth1. The correlation of activity of peroxisomal catalase and AO isogenic form 1 in different conditions evidenced the existence of common regulatory elements for genes AUG2 and CTA1 in methilotrophic yeast Pichia methanolica.

The keto-enol equilibrium in substituted acetaldehydes: focal-point analysis and ab initio limit

NASA Astrophysics Data System (ADS)

Balabin, Roman M.

2011-10-01

High-level ab initio electronic structure calculations up to the CCSD(T) theory level, including extrapolations to the complete basis set (CBS) limit, resulted in high precision energetics of the tautomeric equilibrium in 2-substituted acetaldehydes (XH2C-CHO). The CCSD(T)/CBS relative energies of the tautomers were estimated using CCSD(T)/aug-cc-pVTZ, MP3/aug-cc-pVQZ, and MP2/aug-cc-pV5Z calculations with MP2/aug-cc-pVTZ geometries. The relative enol (XHC = CHOH) stabilities (ΔE e,CCSD(T)/CBS) were found to be 5.98 ± 0.17, -1.67 ± 0.82, 7.64 ± 0.21, 8.39 ± 0.31, 2.82 ± 0.52, 10.27 ± 0.39, 9.12 ± 0.18, 5.47 ± 0.53, 7.50 ± 0.43, 10.12 ± 0.51, 8.49 ± 0.33, and 6.19 ± 0.18 kcal mol-1 for X = BeH, BH2, CH3, Cl, CN, F, H, NC, NH2, OCH3, OH, and SH, respectively. Inconsistencies between the results of complex/composite energy computations methods Gn/CBS (G2, G3, CBS-4M, and CBS-QB3) and high-level ab initio methods (CCSD(T)/CBS and MP2/CBS) were found. DFT/aug-cc-pVTZ results with B3LYP, PBE0 (PBE1PBE), TPSS, and BMK density functionals were close to the CCSD(T)/CBS levels (MAD = 1.04 kcal mol-1).

Functional Characterization of the Role of the N-terminal Domain of the c/Nip1 Subunit of Eukaryotic Initiation Factor 3 (eIF3) in AUG Recognition*

PubMed Central

Karásková, Martina; Gunišová, Stanislava; Herrmannová, Anna; Wagner, Susan; Munzarová, Vanda; Valášek, Leoš Shivaya

2012-01-01

In eukaryotes, for a protein to be synthesized, the 40 S subunit has to first scan the 5′-UTR of the mRNA until it has encountered the AUG start codon. Several initiation factors that ensure high fidelity of AUG recognition were identified previously, including eIF1A, eIF1, eIF2, and eIF5. In addition, eIF3 was proposed to coordinate their functions in this process as well as to promote their initial binding to 40 S subunits. Here we subjected several previously identified segments of the N-terminal domain (NTD) of the eIF3c/Nip1 subunit, which mediates eIF3 binding to eIF1 and eIF5, to semirandom mutagenesis to investigate the molecular mechanism of eIF3 involvement in these reactions. Three major classes of mutant substitutions or internal deletions were isolated that affect either the assembly of preinitiation complexes (PICs), scanning for AUG, or both. We show that eIF5 binds to the extreme c/Nip1-NTD (residues 1–45) and that impairing this interaction predominantly affects the PIC formation. eIF1 interacts with the region (60–137) that immediately follows, and altering this contact deregulates AUG recognition. Together, our data indicate that binding of eIF1 to the c/Nip1-NTD is equally important for its initial recruitment to PICs and for its proper functioning in selecting the translational start site. PMID:22718758

Hatch Opening OPS

NASA Image and Video Library

2009-08-31

S128-E-007008 (30 Aug. 2009) --- Astronauts Rick Sturckow (right), STS-128 commander; and Patrick Forrester, mission specialist, are pictured near the hatch on the middeck of Space Shuttle Discovery after docking with the International Space Station. The two spacecraft docked at 7:54 p.m. (CDT), and the Discovery crew entered the orbital outpost at 9:59 p.m. (CDT) on Aug. 30.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Beatrice, NE)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from Beatrice, Nebraska.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Salem, OR)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from Salem, Oregon.

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2012 CFR

2012-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2013 CFR

2013-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

40 CFR 61.01 - Lists of pollutants and applicability of part 61.

Code of Federal Regulations, 2014 CFR

2014-07-01

...; June 10, 1985) Methylene Chloride (50 FR 42037; Oct. 17, 1985) Nickel (51 FR 34135; Sept. 25, 1986... Chloride (40 FR 59532; Dec. 24, 1975) (b) The following list presents other substances for which a Federal...) Vinylidene Chloride (50 FR 32632; Aug. 13, 1985) Zinc and Zinc Oxide (52 FR 32597, Aug. 28, 1987) (c) This...

USSR Report, Chemistry

DTIC Science & Technology

1987-02-10

4, Jul-Aug 86) CATALYSIS Reaction of Active Component of Vanadium-Sulfur Catalysts With Water Vapor (V. N. Krasilnikov, A. A. Ivakin, et al...Vyunov, et al.; ZHURNAL PRIKLADNOY KHIMII, No 7, Jul 86) 7 Preparation and Catalytic Activity of Metal Molybdates in Oxidative Dehydrogenation of...Exhaust Gases From Plants (Yu. Sh. Matros, V. A. Chumachenko; KHIMICHESKAYA TECHNOLOGIYA, No 4, Jul-Aug 86). 23 COMBUSTION Metallurgy and Optics

48 CFR 1052.234-70 - Notice of Earned Value Management System-Pre-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2014 CFR

2014-10-01

... Management System-Pre-Award IBR (Core) AUG 2011 1052.234-70 Section 1052.234-70 Federal Acquisition... Texts of Provisions and Clauses 1052.234-70 Notice of Earned Value Management System—Pre-Award IBR (Core... require the Contractor to use an earned value management system (EVMS) and for which the Government...

48 CFR 1052.234-70 - Notice of Earned Value Management System-Pre-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2012 CFR

2012-10-01

... Management System-Pre-Award IBR (Core) AUG 2011 1052.234-70 Section 1052.234-70 Federal Acquisition... Texts of Provisions and Clauses 1052.234-70 Notice of Earned Value Management System—Pre-Award IBR (Core... require the Contractor to use an earned value management system (EVMS) and for which the Government...

48 CFR 1052.234-70 - Notice of Earned Value Management System-Pre-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2013 CFR

2013-10-01

... Management System-Pre-Award IBR (Core) AUG 2011 1052.234-70 Section 1052.234-70 Federal Acquisition... Texts of Provisions and Clauses 1052.234-70 Notice of Earned Value Management System—Pre-Award IBR (Core... require the Contractor to use an earned value management system (EVMS) and for which the Government...

Bone Conduction Communication: Research Progress and Directions

DTIC Science & Technology

2017-08-16

ARL-TR-8096 ● AUG 2017 US Army Research Laboratory Bone Conduction Communication: Research Progress and Directions by Maranda...this report when it is no longer needed. Do not return it to the originator. ARL-TR-8096 ● AUG 2017 US Army Research Laboratory...Bone Conduction Communication: Research Progress and Directions by Maranda McBride North Carolina Agricultural and Technical State University

Southeast Asia Report

DTIC Science & Technology

1984-08-24

world problems, for social progress and world peace. CSO: 4200/957 85 INTERNATIONAL RELATIONS, TRADE AND AID BRIEFS BRITISH SUPPORT FOR SRV— Hanoi ...Mahathir on Economic Ties With Australasia (Lumpur International Service, 8 Aug 84) 15 Briefs Visa Retaliatory Move Against India 16 NEW ZEALAND...VIETNAM INTERNATIONAL RELATIONS, TRADE AND AID Ceausescu Receives New Vietnamese Envoys (AGERPRES, 9 Aug 84) 85 Briefs British Support for SRV

48 CFR 1052.234-70 - Notice of Earned Value Management System-Pre-Award IBR (Core) AUG 2011

Code of Federal Regulations, 2011 CFR

2011-10-01

... Management System-Pre-Award IBR (Core) AUG 2011 1052.234-70 Section 1052.234-70 Federal Acquisition... Texts of Provisions and Clauses 1052.234-70 Notice of Earned Value Management System—Pre-Award IBR (Core... require the Contractor to use an earned value management system (EVMS) and for which the Government...

Genetics Home Reference: autosomal dominant hyper-IgE syndrome

MedlinePlus

... binding domain of STAT3 cause hyper-IgE syndrome. Nature. 2007 Aug 30;448(7157):1058-62. Epub 2007 Aug 5. Citation on PubMed Renner ED, Torgerson TR, Rylaarsdam S, Añover-Sombke S, Golob K, LaFlam T, Zhu Q, Ochs HD. STAT3 mutation in the original patient with Job's syndrome. N Engl J Med. 2007 Oct 18; ...

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Apollo 11 Astronauts Michael Collins, left, NASA Deputy Administrator Lori Garver and NASA Administrator Charles Bolden, right, talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Carol Armstrong, wife of Neil Armstrong, and Piper Van Wagenen, one of 10 grandchildren, are seen during a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

The flares of August 1972. [solar flare characteristics and spectra

NASA Technical Reports Server (NTRS)

Zirin, H.; Tanaka, K.

1973-01-01

Observations of the August, 1972 flares at Big Bear and Tel Aviv, involving monochromatic movies, magnetograms, and spectra, are analyzed. The region (McMath 11976) showed inverted polarity from its inception on July 11; the great activity was due to extremely high shear and gradients in the magnetic field, as well as a constant invasion of one polarity into the opposite; observations in lambda 3835 show remarkable fast flashes in the impulsive flare of 18:38 UT on Aug. 2 with lifetimes of 5 sec, which may be due to dumping of particles in the lower chromosphere. Flare loops show evolutionary increases of their tilts to the neutral line in the flares of Aug. 4 and 7. Spectroscopic observations show red asymmetry and red shift of the H alpha emission in the flash phase of the Aug. 7 flare, as well as substantial velocity shear in the photosphere during the flare, somewhat like earthquake movement along a fault. Finally the total H alpha emission of the Aug. 7 flare could be measured accurately as about 2.5 x 10 to the 30th power erg, considerably less than coarser previous estimates for great flares.

Approximations to complete basis set-extrapolated, highly correlated non-covalent interaction energies.

PubMed

Mackie, Iain D; DiLabio, Gino A

2011-10-07

The first-principles calculation of non-covalent (particularly dispersion) interactions between molecules is a considerable challenge. In this work we studied the binding energies for ten small non-covalently bonded dimers with several combinations of correlation methods (MP2, coupled-cluster single double, coupled-cluster single double (triple) (CCSD(T))), correlation-consistent basis sets (aug-cc-pVXZ, X = D, T, Q), two-point complete basis set energy extrapolations, and counterpoise corrections. For this work, complete basis set results were estimated from averaged counterpoise and non-counterpoise-corrected CCSD(T) binding energies obtained from extrapolations with aug-cc-pVQZ and aug-cc-pVTZ basis sets. It is demonstrated that, in almost all cases, binding energies converge more rapidly to the basis set limit by averaging the counterpoise and non-counterpoise corrected values than by using either counterpoise or non-counterpoise methods alone. Examination of the effect of basis set size and electron correlation shows that the triples contribution to the CCSD(T) binding energies is fairly constant with the basis set size, with a slight underestimation with CCSD(T)∕aug-cc-pVDZ compared to the value at the (estimated) complete basis set limit, and that contributions to the binding energies obtained by MP2 generally overestimate the analogous CCSD(T) contributions. Taking these factors together, we conclude that the binding energies for non-covalently bonded systems can be accurately determined using a composite method that combines CCSD(T)∕aug-cc-pVDZ with energy corrections obtained using basis set extrapolated MP2 (utilizing aug-cc-pVQZ and aug-cc-pVTZ basis sets), if all of the components are obtained by averaging the counterpoise and non-counterpoise energies. With such an approach, binding energies for the set of ten dimers are predicted with a mean absolute deviation of 0.02 kcal/mol, a maximum absolute deviation of 0.05 kcal/mol, and a mean percent absolute deviation of only 1.7%, relative to the (estimated) complete basis set CCSD(T) results. Use of this composite approach to an additional set of eight dimers gave binding energies to within 1% of previously published high-level data. It is also shown that binding within parallel and parallel-crossed conformations of naphthalene dimer is predicted by the composite approach to be 9% greater than that previously reported in the literature. The ability of some recently developed dispersion-corrected density-functional theory methods to predict the binding energies of the set of ten small dimers was also examined. © 2011 American Institute of Physics

Big Sunspot Group

NASA Image and Video Library

2015-08-26

A large group of sunspots that rotated across the Sun over six days (Aug. 21-26, 2015) started out as a single cluster, but gradually separated into distinct groups. This region produced several M-class (medium-sized) flares. These were the only significant spots on the Sun during this period. The still image shows the separated group as it appeared on Aug. 26., 2015. http://photojournal.jpl.nasa.gov/catalog/PIA19876

Northrop Grumman Corporation's modified U.S. Navy F-5E Shaped Sonic Boom Demonstration (SSBD) aircraft flies over Lake Isabella, Calif., on Aug. 4, 2003

NASA Image and Video Library

2003-08-04

Northrop Grumman Corporation's modified U.S. Navy F-5E Shaped Sonic Boom Demonstration (SSBD) aircraft flies over Lake Isabella, California on Aug. 4, 2003. NASA Dryden provided range, air and ground data-gathering support for the SSBD project, which is part of DARPA's Quiet Supersonic Platform (QSP) program.

Hatch Opening OPS

NASA Image and Video Library

2009-08-31

S128-E-007010 (30 Aug. 2009) --- Astronauts Rick Sturckow (bottom), STS-128 commander; John “Danny” Olivas (right) and Patrick Forrester, both mission specialists, are pictured near the hatch on the middeck of Space Shuttle Discovery after docking with the International Space Station. The two spacecraft docked at 7:54 p.m. (CDT), and the Discovery crew entered the orbital outpost at 9:59 p.m. (CDT) on Aug. 30.

Earth Observations taken by the Expedition 17 Crew

NASA Image and Video Library

2008-08-19

ISS017-E-013843 (19 Aug. 2008) --- A panoramic view of the island of Hispaniola in the foreground and Cuba extending to over the horizon. The sunglint is illuminating Haiti and the Dominican Republic while the thunderstorms persist in the late afternoon of the summertime day. Taken by the Expedition 17 crew onboard the ISS on Aug 19, 2008 with a 28 mm lens.

11 CFR 102.2 - Statement of organization: Forms and committee identification number (2 U.S.C. 433 (b), (c)).

Code of Federal Regulations, 2010 CFR

2010-01-01

... boxes, or other depositories used by the committee; (vii) The Internet address of the committee's... on all communications concerning reports and statements. [45 FR 15104, Mar. 7, 1980, as amended at 50 FR 50778, Dec. 12, 1985; 54 FR 34109, Aug. 17, 1989; 54 FR 48580, Nov. 24, 1989; 58 FR 42173, Aug. 6...

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Exploratorium, Madras, OR)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from the Exploratorium in Madras, Oregon.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Carbondale, IL)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from Southern Illinois University in Carbondale, Illinois.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Solar Dynamics Observatory)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from NASA’s Solar Dynamics Observatory.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (The International Space Station)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from The International Space Station.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Hopkinsville_KY)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from the Homestead National Monument in Hopkinsville, Kentucky.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Jefferson City, MO)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from Jefferson City, Missouri.

Cation-Cation pi-pi Stacking in Small Ionic Clusters of 1,2,4-Triazolium

DTIC Science & Technology

2008-01-01

ZPE ) obtained with MP2/aug-cc-pVDZ harmonic vibrational frequencies, the ionic tetramer is 1.2 kcal/mol lower in energy than that of the neutral one...respectively. Including ZPE , these three values become 5.7, 7.3, and 7.7 kcal/mol, respectively. Further corrections for the basis set effects from aug-cc-pVDZ

Acquisition of an Adiabatic Demagnetization Refrigerator for Quantum Information Science with Superconducting Circuits

DTIC Science & Technology

2015-11-23

SECURITY CLASSIFICATION OF: The DURIP award provided funds for acquiring a cryogen-free adiabatic demagnetization refrigerator at Syracuse University...The new refrigerator has been installed and is now fully operational. The PI has intensive research efforts in the area of Quantum Information...Aug-2014 24-Aug-2015 Approved for Public Release; Distribution Unlimited Final Report: Acquisition of an Adiabatic Demagnetization Refrigerator for

Date Sensitive Computing Problems: Understanding the Threat

DTIC Science & Technology

1998-08-29

equipment on Earth.3 It can also interfere with electromagnetic signals from such devices as cell phones, radio, televison , and radar. By itself, the ...spacecraft. Debris from impacted satellites will add to the existing orbital debris problem, and could eventually cause damage to other satellites...Date Sensitive Computing Problems Understanding the Threat Aug. 17, 1998 Revised Aug. 29, 1998 Prepared by: The National Crisis Response

Astronaut Owen Garriott participates in EVA to deploy twin pole solar shield

NASA Image and Video Library

1973-08-06

SL3-117-2109 (6 Aug. 1973) --- Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, participates in the Aug. 6, 1973 extravehicular activity (EVA) during which he and astronaut Jack Lousma, Skylab 3 pilot, deployed the twin pole solar shield to help shade the Orbital Workshop (OWS). Note the reflection of the solar shield in Garriott's helmet visor. Photo credit: NASA

View of Crewmembers in the SM during STS-118/Expedition 15 Joint Operations

NASA Image and Video Library

2007-08-18

S118-E-09261 (18 Aug. 2007) --- Astronaut Barbara R. Morgan, STS-118 mission specialist, uses a video camera during a farewell ceremony in the Zvezda Service Module of the International Space Station. Astronaut Tracy Caldwell, mission specialist, is visible at right. Hatches were closed between the station and Space Shuttle Endeavour at 4:10 p.m. on Aug. 18.

Alternative Fuels Data Center: Austin Lays Plans for Carbon-Neutral City

Science.gov Websites

Biodiesel Aug. 26, 2017 Photo of a car Idaho Surges Ahead with Electric Vehicle Charging Aug. 4, 2017 Photo of a truck Cooking Oil Powers Biodiesel Vehicles in Rhode Island July 14, 2017 Photo of a truck Idaho Largest Home Runs on Biodiesel in North Carolina June 9, 2017 Photo of a bus New Hampshire Cleans up with

High Spatiotemporal Resolution Prostate MRI

DTIC Science & Technology

2016-09-01

1 AD AWARD NUMBER: W81XWH-15-1-0341 TITLE: High Spatiotemporal Resolution Prostate MRI PRINCIPAL INVESTIGATOR: Stephen J. Riederer CONTRACTING...REPORT TYPE Annual 3. DATES COVERED 15 Aug 2015 - 14 Aug 2016 4. TITLE AND SUBTITLE High Spatiotemporal Resolution Prostate MRI 5a. CONTRACT NUMBER...improved means using MRI for detecting prostate cancer with the potential for differentiating disease aggressiveness. The hypothesis is that dynamic

Expedition 15 Progress 26 Launch

NASA Image and Video Library

2007-08-02

JSC2007-E-41113(2 Aug. 2007) --- The ISS Progress 26 launched Aug. 2 from the Baikonur Cosmodrome in Kazakhstan on time at 12:33:46 pm (CDT) and 11:33:46 pm, Baikonur time. Ascent was nominal and by the book. Once in orbit, the Progress separated from the third stage of the booster and all appendages and antennas were deployed on time. Photo Credit: NASA/Mark Bowman

Earth Observation

NASA Image and Video Library

2014-08-10

ISS040-E-091153 (10 Aug. 2014) --- One of the Expedition 40 crew members aboard the International Space Station, flying at an altitude of 225 nautical miles, exposed this image of the south end of New Zealand's North Island on Aug. 10, 2014. Lake Wellington is just to the right of center frame. The north end of South Island is out of frame on the right side of Cook Strait at far right.

IR low-temperature matrix, X-ray and ab initio study on L-isoserine conformations.

PubMed

Dobrowolski, Jan Cz; Jamróz, Michał H; Kołos, Robert; Rode, Joanna E; Cyrański, Michał K; Sadlej, Joanna

2010-09-28

The IR low-temperature Ar and Kr matrix spectra of l-isoserine were registered for the first time and interpreted by means of the anharmonic DFT frequencies calculated at the B3LYP/aug-cc-pVTZ and B3LYP/aug-cc-pVDZ levels. 54 l-isoserine conformers were predicted to be stable at the B3LYP/aug-cc-pVDZ level. Population of the 8 most stable conformers was based on the QCISD/aug-cc-pVDZ energies, corrected for thermal anharmonic factors obtained at the B3LYP/aug-cc-pVDZ level. We found several conformers to be present in the measured matrices and conformer 1 to be dominating. Presence of the conformer 2 is well confirmed by the nu(C=O) band at 1790 cm(-1) and two bands at 1380 and 1350 cm(-1). Presence of the conformer 4 is quite well confirmed by the nu(C-O) bands at 1120 and 1095 cm(-1). Slightly weaker arguments are found for the observation of conformers 6 and 3. Calculations on 54 neutral and 5 zwitterionic conformers in water at the IEF-PCM/B3LYP/aug-cc-pVDZ level suggest that one neutral and one zwitterionic conformer co-exist in the aqueous environment. The crystal structure of l-isoserine was solved by X-ray diffraction analysis. The compound crystallizes without solvent in the chiral P2(1)2(1)2 space group. The asymmetric unit contains a single molecule. The molecule is in its zwitterionic form with the CH(2)-NH(3) side chain in the gauche conformation with respect to the hydroxyl group and in the anti conformation with respect to the carboxylate group. The structure of l-isoserine is dominated by a set of intermolecular hydrogen bonds. The strongest one appears between the OH and COOH groups of two neighbouring molecules: the O...H contact is of 1.66(2) A, which is amongst the shortest H-bonds of this kind observed in amino acid crystal structures.

An expanded calibration study of the explicitly correlated CCSD(T)-F12b method using large basis set standard CCSD(T) atomization energies.

PubMed

Feller, David; Peterson, Kirk A

2013-08-28

The effectiveness of the recently developed, explicitly correlated coupled cluster method CCSD(T)-F12b is examined in terms of its ability to reproduce atomization energies derived from complete basis set extrapolations of standard CCSD(T). Most of the standard method findings were obtained with aug-cc-pV7Z or aug-cc-pV8Z basis sets. For a few homonuclear diatomic molecules it was possible to push the basis set to the aug-cc-pV9Z level. F12b calculations were performed with the cc-pVnZ-F12 (n = D, T, Q) basis set sequence and were also extrapolated to the basis set limit using a Schwenke-style, parameterized formula. A systematic bias was observed in the F12b method with the (VTZ-F12/VQZ-F12) basis set combination. This bias resulted in the underestimation of reference values associated with small molecules (valence correlation energies <0.5 E(h)) and an even larger overestimation of atomization energies for bigger systems. Consequently, caution should be exercised in the use of F12b for high accuracy studies. Root mean square and mean absolute deviation error metrics for this basis set combination were comparable to complete basis set values obtained with standard CCSD(T) and the aug-cc-pVDZ through aug-cc-pVQZ basis set sequence. However, the mean signed deviation was an order of magnitude larger. Problems partially due to basis set superposition error were identified with second row compounds which resulted in a weak performance for the smaller VDZ-F12/VTZ-F12 combination of basis sets.

PU-ICE Summary Information.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, Michael

The Generator Knowledge Report for the Plutonium Isentropic Compression Experiment Containment Systems (GK Report) provides information for the Plutonium Isentropic Compression Experiment (Pu- ICE) program to support waste management and characterization efforts. Attachment 3-18 presents generator knowledge (GK) information specific to the eighteenth Pu-ICE conducted in August 2015, also known as ‘Shot 18 (Aug 2015) and Pu-ICE Z-2841 (1).’ Shot 18 (Aug 2015) was generated on August 28, 2015 (1). Calculations based on the isotopic content of Shot 18 (Aug 2015) and the measured mass of the containment system demonstrate the post-shot containment system is low-level waste (LLW). Therefore, thismore » containment system will be managed at Sandia National Laboratory/New Mexico (SNL/NM) as LLW. Attachment 3-18 provides documentation of the TRU concentration and documents the concentration of any hazardous constituents.« less

SMAP Global Map of Surface Soil Moisture Aug. 25-27, 2015

NASA Image and Video Library

2015-09-02

A three-day composite global map of surface soil moisture as retrieved from NASA SMAP radiometer instrument between Aug. 25-27, 2015. Dry areas appear yellow/orange, such as the Sahara Desert, western Australia and the western U.S. Wet areas appear blue, representing the impacts of localized storms. White areas indicate snow, ice or frozen ground. http://photojournal.jpl.nasa.gov/catalog/PIA19877

View of STS-118 MS Morgan in the SPACEHAB

NASA Image and Video Library

2007-08-17

S118-E-07765 (17 Aug. 2007) --- Astronaut Barbara R. Morgan, mission specialist, finds herself surrounded by supplies in SPACEHAB, located in the cargo bay of the Space Shuttle Endeavour. Supply transfer was one of the main activities on the agenda Aug. 17 for the STS-118 crewmembers, who learned their anticipated departure from the International Space Station will come a day earlier due to possible weather issues back home.

Northrop Grumman Corporation's modified U.S. Navy F-5E Shaped Sonic Boom Demonstration (SSBD) aircraft flies over the company's Palmdale, Calif. facilities on Aug. 2, 2003

NASA Image and Video Library

2003-08-02

Northrop Grumman Corporation's modified U.S. Navy F-5E Shaped Sonic Boom Demonstration (SSBD) aircraft flies over the company's Palmdale, California facilities on Aug. 2, 2003. NASA Dryden provided range, air and ground data-gathering support for the SSBD project, which is part of DARPA's Quiet Supersonic Platform (QSP) program.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Rocky Mountains)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from Great Smoky Mountains National Park (North Carolina and Tennessee).

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Idaho Falls, ID)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from the Museum of Idaho, in Idaho Falls.

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (Clarksville, TN – Austin Peay)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from Austin Peay State University, in Clarksville, TN.

Latin America Report. No. 2738.

DTIC Science & Technology

1983-09-14

Ramirez Mercado Dr Rafael Cordova Rivas 2909 CSO: 3248/1197 5k COUNTRY SECTION VENEZUELA HERRERA CAMPINS’ MOTORCADE INVOLVED IN TRAFFIC...EL MUNDO, 8 Aug 83) 42 NICARAGUA Draft Law on Patriotic Military Service Published (BARRICADA, 10 Aug 83) 44 VENEZUELA Herrera Campins...solution to conflicts, since the effects of strikes do not always leave the best memories of what could be a fair labor claim. Why then not better

High Spatiotemporal Resolution Prostate MRI

DTIC Science & Technology

2017-09-01

AWARD NUMBER: W81XWH-15-1-0341 TITLE: High Spatiotemporal Resolution Prostate MRI PRINCIPAL INVESTIGATOR: Stephen J. Riederer, Ph.D...views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army...ADDRESS. 1. REPORT DATE September 2017 2. REPORT TYPE Annual 3. DATES COVERED 15 Aug 2016 - 14 Aug 2017 4. TITLE AND SUBTITLE High Spatiotemporal

Prostate Cancer Genetics in African Americans

DTIC Science & Technology

2014-09-01

ADDRESS. 1. REPORT DATE 2 . REPORT TYPE Annual 3. DATES COVERED 15 Aug 2013 – 14 Aug 2014 4. TITLE AND SUBTITLE Prostate Cancer Genetics in...first two years of this grant has involved (1) hiring and training of culturally competent research personnel; ( 2 ) the establishment of a project...was no indication of familial prostate cancer. Task 2 : Data Collection and Management (Years 1- 3) The study-specific database has been

JPRS Report, Soviet Union, Political Affairs.

DTIC Science & Technology

1989-10-03

18000602 Moscow PRA VDA in Russian 2 Aug 88 p 3 [Article by I . Zarakhovich and T . Trukhacheva, journal- ists, and Ye. Sokolova, member, Central Council...QTJAUn INSP1CH3B t Soviet Union Political Affairs JPRS-UPA-88-044 CONTENTS 03 OCTOBER 1989 PARTY, STATE AFFAIRS History of Formation of Nagorno...Advocated //. Zarakhovich, T . Trukhacheva; PRAVDA, 2 Aug 88] 86 REGIONAL ISSUES Biologist on Costs of Pollution Control Measures [A. Valentey

Preclinical Testing of Novel Oxytocin Receptor Activators in Models of Autism Phenotypes

DTIC Science & Technology

2014-09-01

AD_________________ Award Number: TITLE: Preclinical Testing of Novel Oxytocin Receptor Activators in Models of Autism ...AUG 2013-7 Aug 2014 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Preclinical Testing of Novel Oxytocin Receptor Activators in Models of Autism ...a genetic mouse model of autism -like phenotypes, the Grin1 knockdown mouse. The Grin1 gene encodes the NR1 subunit of the NMDA receptor . In the

Robust Quantum Computing using Molecules with Switchable Dipole

DTIC Science & Technology

2010-06-15

REPORT Robust quantum computing using molecules with switchable dipole 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: Of the many systems studied to...Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS Ultracold polar molecules, quantum computing , phase gates...From - To) 30-Aug-2006 Standard Form 298 (Rev 8/98) Prescribed by ANSI Std. Z39.18 - 31-Aug-2009 Robust quantum computing using molecules with

Improving Survival and Promoting Respiratory Motor Function after Cervical Spinal Cord Injury

DTIC Science & Technology

2016-09-01

AWARD NUMBER: W81XWH-15-1-0378 TITLE: Improving Survival and Promoting Respiratory Motor Function after Cervical Spinal Cord Injury PRINCIPAL...Aug 2015 - 14 Aug 2016 4. TITLE AND SUBTITLE CordCorInjury 5a. CONTRACT NUMBER Improvi g Survival and Promoting Respiratory Motor Function After... respiratory complications. This application proposes to help improve survival, decrease early dependence on mechanical ventilation, and restore breathing

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Apollo 13 Astronaut Jim Lovell, left, former NASA Administrator Dan Goldin, Sen. John Glenn, third from left, and NASA Administrator Charles Bolden, right, talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Site Investigation Report for Fort McClellan, Alabama

DTIC Science & Technology

1993-08-31

used 55 Assumed RD or VX used BG Bacillus Gobi SM Serratia Marcescens Reference: Solid Waste Study No. 99-056-73/76, Fort McClellan, AL, Jul 73-Aug...Bacillus Gobi SM Serratia Marcescens STB Supertropical Bleach Reference: Solid Waste Study No. 99-056-73/76, Fort McClellan, AL, Jul 73-Aug 75...REPORT ORGANIZATION ................................ 1-1 1.4 FACILITY BACKGROUND ............................... 1-3 1.4.1 Post Description and History

Multimillion Atom Reactive Simulations of Nanostructured Energetic Materials

DTIC Science & Technology

2007-08-01

code) 2007 Reprint Aug 2006-Aug 2007 Multimillion Atom Reactive Simulations of Nanostructured Energetic Materials W911NF-04-1-0178 sub 2781-USC-DOA...Priya Vashishta 213 821 2663 Reset Multimillion Atom Reactive Simulations of Nanostructured Energetic Materials Priya Vashishta,∗ Rajiv K. Kalia...function of the particle velocity that drives the shock [18]. The MD and experimental data agree very well. Furthermore, the simulation shows a sudden

Modification of orthogonal tRNAs: unexpected consequences for sense codon reassignment.

PubMed

Biddle, Wil; Schmitt, Margaret A; Fisk, John D

2016-12-01

Breaking the degeneracy of the genetic code via sense codon reassignment has emerged as a way to incorporate multiple copies of multiple non-canonical amino acids into a protein of interest. Here, we report the modification of a normally orthogonal tRNA by a host enzyme and show that this adventitious modification has a direct impact on the activity of the orthogonal tRNA in translation. We observed nearly equal decoding of both histidine codons, CAU and CAC, by an engineered orthogonal M. jannaschii tRNA with an AUG anticodon: tRNA Opt We suspected a modification of the tRNA Opt AUG anticodon was responsible for the anomalous lack of codon discrimination and demonstrate that adenosine 34 of tRNA Opt AUG is converted to inosine. We identified tRNA Opt AUG anticodon loop variants that increase reassignment of the histidine CAU codon, decrease incorporation in response to the histidine CAC codon, and improve cell health and growth profiles. Recognizing tRNA modification as both a potential pitfall and avenue of directed alteration will be important as the field of genetic code engineering continues to infiltrate the genetic codes of diverse organisms. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

The compact neutron spectrometer at ASDEX Upgrade.

PubMed

Giacomelli, L; Zimbal, A; Tittelmeier, K; Schuhmacher, H; Tardini, G; Neu, R

2011-12-01

The first neutron spectrometer of ASDEX Upgrade (AUG) was installed in November 2008. It is a compact neutron spectrometer (CNS) based on a BC501A liquid scintillating detector, which can simultaneously measure 2.45-MeV and 14-MeV neutrons emitted from deuterium (D) plasmas and γ radiation. The scintillating detector is coupled to a digital pulse shape discrimination data acquisition (DPSD) system capable of count rates up to 10(6) s(-1). The DPSD system can operate in acquisition and processing mode. With the latter n-γ discrimination is performed off-line based on the two-gate method. The paper describes the tests of the CNS and its installation at AUG. The neutron emission from the D plasma measured during a discharge with high auxiliary heating power was used to validate the CNS performance. The study of the optimal settings for the DPSD data processing to maximize the n-γ discrimination capability of the CNS is reported. The CNS measured both 2.45-MeV and 14-MeV neutrons emitted in AUG D plasmas with a maximum count rate of 5.4 × 10(5) s(-1) (>10 times higher than similar spectrometers previously achieved) with an efficiency of 9.3 × 10(-10) events per AUG neutron.

Lost in Translation: Bioinformatic Analysis of Variations Affecting the Translation Initiation Codon in the Human Genome.

PubMed

Abad, Francisco; de la Morena-Barrio, María Eugenia; Fernández-Breis, Jesualdo Tomás; Corral, Javier

2018-06-01

Translation is a key biological process controlled in eukaryotes by the initiation AUG codon. Variations affecting this codon may have pathological consequences by disturbing the correct initiation of translation. Unfortunately, there is no systematic study describing these variations in the human genome. Moreover, we aimed to develop new tools for in silico prediction of the pathogenicity of gene variations affecting AUG codons, because to date, these gene defects have been wrongly classified as missense. Whole-exome analysis revealed the mean of 12 gene variations per person affecting initiation codons, mostly with high (> 0:01) minor allele frequency (MAF). Moreover, analysis of Ensembl data (December 2017) revealed 11,261 genetic variations affecting the initiation AUG codon of 7,205 genes. Most of these variations (99.5%) have low or unknown MAF, probably reflecting deleterious consequences. Only 62 variations had high MAF. Genetic variations with high MAF had closer alternative AUG downstream codons than did those with low MAF. Besides, the high-MAF group better maintained both the signal peptide and reading frame. These differentiating elements could help to determine the pathogenicity of this kind of variation. Data and scripts in Perl and R are freely available at https://github.com/fanavarro/hemodonacion. jfernand@um.es. Supplementary data are available at Bioinformatics online.

Long-Range Forecasting in Support of Operations in Pakistan

DTIC Science & Technology

2011-03-01

climate variation, respectively. ....... 11 Table 2. Schematic contingency table used to verify hindcasts of Jul-Aug Pakistan PR. The cells of the table...IRI is a component of Columbia University located in Palisades , NY. IRI’s mission is to increase society’s awareness of the impact of climate on...Jul-Aug Pakistan PR. The cells of the table represent the number and combinations of observed occurrences (obs Y), observed non- occurrences (obs N

View of Morgan in the SPACEHAB Module during the STS-118 Mission

NASA Image and Video Library

2007-08-17

S118-E-07813 (17 Aug. 2007) --- Astronaut Barbara R. Morgan, mission specialist, is surrounded by supplies in SPACEHAB, located in the cargo bay of the Space Shuttle Endeavour. Supply transfer was one of the main activities on the agenda Aug. 17 for the STS-118 crewmembers, who learned their anticipated departure from the International Space Station will come a day earlier due to possible weather issues back home.

STS-28 crewmembers' wives at KSC shuttle landing facility (SLF) with banner

NASA Image and Video Library

1989-08-05

STS028-S-009 (5 Aug 1989) --- Wives of the STS-28 crewmembers display a banner upon the arrival of the astronauts in Florida to begin preparing for their Aug. 8 launch. Left to right are Susan Adamson, Kathleen Ann Shaw, Lynne A. Brown, Lois Richards and Patti K. Leestma. The banner reads, "Go Columbia, STS-28." Launch for the Department of Defense (DOD)-devoted mission is scheduled for August 8.

JPRS Report, East Asia, Southeast Asia.

DTIC Science & Technology

1988-11-30

realignment in the Dewan Rakyat [lower house] be predetermined for the session of Parliament which begins on 10 October. Political observers say that this...Bolikhamsai Banking Operations PASASON 30 AugJ 2 Dollar-Denominated Fuel Prices, Danang Operations Noted fPASASON 20 AugJ 3 MALAYSIA PRCs Tianjin...CompanyDirector JPRS-SEA-88-047 30 November 1988 MALAYSIA PRC’s Tianjin Interested in Importing Products Directly 42050005a Selangor SIN CHEW JIT POH in

Targeting MEK5 Enhances Radiosensitivity of Human Prostate Cancer and Impairs Tumor-Associated Angiogenesis

DTIC Science & Technology

2016-09-01

AWARD NUMBER: W81XWH-15-1-0296 TITLE: Targeting MEK5 Enhances Radiosensitivity of Human Prostate Cancer and Impairs Tumor- Associated...3. DATES COVERED 31 Aug 2015 - 30 Aug 2016 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Targeting MEK5 Enhances Radiosensitivity of Human Prostate...therapeutic modality for the treatment of human prostate cancer. However, tumors often demonstrate resistance to ionizing radiation and continue to

Genetic and Environmental Pathways in Type 1 Diabetes Complications

DTIC Science & Technology

2008-09-01

the “Limit By Function Type” heading opens a new browser window to the online user guide describing the use of this filter when selecting SNPs for...T1D. The juxtaglomerular apparatus comprises different structures in functional and structural link: cells of the extraglomerular mesangium, which fill...27 Aug 2007-26 Aug 2008 4. TITLE AND SUBTITLE Genetic and Environmental Pathways in Type 1 Diabetes Complications New Advanced Technology to

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

U.S. Navy F/A-18 jets from Strike Fighter Squadron (VFA) 106 and Strike Fighter Squadron (VFA) 34, from Naval Air Station Oceana (Va.) fly in a "Missing Man" formation over the Camargo Club following a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

The scanning model for translation: an update

PubMed Central

1989-01-01

The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained. PMID:2645293

7. "AERIAL VIEW OF THE TEST AREA, DIRECTORATE OF MISSILE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. "AERIAL VIEW OF THE TEST AREA, DIRECTORATE OF MISSILE CAPTIVE TEST, EDWARDS AFB. 8 AUG 57." In upper left corner, photo no. "8462 57" cropped out: "A-AFFTC 8 AUG 57, RETL TEST AREA" This photo is a high oblique view, showing the wing of the photo plane and Test Area 1-115. - Edwards Air Force Base, Air Force Rocket Propulsion Laboratory, Leuhman Ridge near Highways 58 & 395, Boron, Kern County, CA

Pakistan’s Domestic Political Developments

DTIC Science & Technology

2005-09-19

Daily Times (Lahore), Aug. 29, 2005; Aamer Ahmed Khan, “Musharraf Under Fire After Local elections,” BBC News, Aug. 30, 2005; Husain Haqqani, “Hit... Ahmed serves as MMA president. Another long-standing Islamist party is the Jamiat Ulema-i-Islam faction led by Maulana Fazlur Rehman (JUI-F). The JUI...Harper Collins India, 2000), p. 135. 37 Pakistani Ambassador to the United States Ashraf Jehangir Qazi, “Transition in Pakistan” (letter), New York

Safety and Immunogenicity Testing of a Pilot Polysaccharide Vaccine Preparation to Pseudomonas aeruginosa.

DTIC Science & Technology

1981-09-01

8217-NAL." BUR-._,AL)- ’..O,.-,.S.AN--DA. .-D-S.... . . . .A AD___________ Safety and Immunogenicity Testing of a Pilot Polysaccharide Vaccine Preparation...COVERED Safety and Immunogenicity Testing of a Pilot Annual Report Polysaccharide Vaccine Preparation to (16 Aug. 80 - 1 Aug. 81) Pseudomonas...immunogenic or biologically active component of the vaccine. The vaccine is a high molecu- lar weight polysaccharide (PS) material isolated from the outer

USSR Report: Electronics and Electrical Engineering

DTIC Science & Technology

1985-01-23

item originate with the source. Times within items are as given by source. The contents of this publication in no way represent the policies, views ...Integrated Optics (V.l. Vol’man, N.D. Kozyrev ; RADIOTEKHNIKA, No 8, Aug 84).. 6 Coordinate Determination Errors in Measuring Characteristics of...I KINEMATOGRAFII, No 4, Jul-Aug 84) . 8 Modified Signal-1 Device for Remote Control of Toys and Models (V. Borisov, A. Proskurin; RADIO, No 6

Translations on Telecommunications Policy, Research and Development, Number 13

DTIC Science & Technology

1977-09-14

9 Aug 77) 4 ATDA Says Research, Development Funds Being Wasted (THE AUSTRALIAN, 15 Aug 77) 5 Digital Unveils New Printer (THE AUSTRALIAN, 22...Argentina Accord 28 BOLIVIA Briefs Bolivian Television Reorganized 29 CUBA New Radio Station for Santa Cruz del Sur ( JUVENTUD REBELDE, 29 Jun 77...II micro- processor. The PM-DS/11 car- tridge disc memory sys- tem provides a double capacity plug-in alter- native to the Digital Equipment

STS-135 New York City Visit

NASA Image and Video Library

2011-08-16

201108160008hq (16 Aug. 2011) --- Stephen Colbert, host of The Colbert Report, salutes the crew of STS-135, seated from lower left, NASA astronauts Chris Ferguson, commander; Doug Hurley, pilot; Sandy Magnus and Rex Walheim, both mission specialists, during their appearance for a taping of his television show, Aug. 16, 2011, in New York. The astronauts from STS-135 are in New York for a three-day visit. Photo credit: NASA/Paul E. Alers

Evaluation of the plasma hydrogen isotope content by residual gas analysis at JET and AUG

NASA Astrophysics Data System (ADS)

Drenik, A.; Alegre, D.; Brezinsek, S.; De Castro, A.; Kruezi, U.; Oberkofler, M.; Panjan, M.; Primc, G.; Reichbauer, T.; Resnik, M.; Rohde, V.; Seibt, M.; Schneider, P. A.; Wauters, T.; Zaplotnik, R.; ASDEX-Upgrade, the; EUROfusion MST1 Teams; contributors, JET

2017-12-01

The isotope content of the plasma reflects on the dynamics of isotope changeover experiments, efficiency of wall conditioning and the performance of a fusion device in the active phase of operation. The assessment of the isotope ratio of hydrogen and methane molecules is used as a novel method of assessing the plasma isotope ratios at JET and ASDEX-Upgrade (AUG). The isotope ratios of both molecules in general shows similar trends as the isotope ratio detected by other diagnostics. At JET, the absolute values of RGA signals are in relatively good agreement with each other and with spectroscopy data, while at AUG the deviation from neutral particle analyser data are larger, and the results show a consistent spatial distribution of the isotope ratio. It is further shown that the isotope ratio of the hydrogen molecule can be used to study the degree of dissociation of the injected gas during changeover experiments.

Preliminary Seismological Report on the 6 August 2007 Crandall Canyon Mine Collapse in Utah

NASA Astrophysics Data System (ADS)

Pechmann, J. C.; Arabasz, W. J.; Pankow, K. L.; Burlacu, R.; McCarter, M. K.

2007-12-01

A large and tragic collapse occurred in the Crandall Canyon coal mine in east-central Utah on 6 Aug 2007, causing the loss of six miners and generating national attention. This collapse was accompanied by a local magnitude (ML) 3.9 seismic event having an origin time of 2:48 am MDT (8:48 UTC) and a location near the collapse. Two lines of evidence indicate that most of the seismic wave energy of this event was generated by the mine collapse rather than an earthquake: (1) the observation that all of the P-wave first motion directions are down and (2) the results of a moment tensor inversion by Ford et al. (2007; http://seismo.berkeley.edu/seismo/Homepage.html). The Crandall Canyon mine is in an area of Utah where there is abundant mining-induced seismicity, including events with both collapse and shear-slip sources. Prior to the 6 Aug collapse, and within a 3 km radius of it, there were 28 seismic events during 2007 that were large enough to be detected and located as part of the routine processing of University of Utah regional seismic network data: 8 in the 2.5-week period prior to the collapse (ML ≤ 1.9) and 15 during an earlier period of activity in late February and early March (ML ≤ 1.8). The 6 Aug collapse was followed by 37 locatable seismic events of ML ≤ 2.2 before the end of August. One of these "aftershocks" (ML 1.6) occurred in conjunction with the violent burst of coal from the mine walls on 17 Aug (UTC) that killed three rescuers. The aftershocks have an exponential frequency-magnitude distribution with a lower ratio between the frequencies of smaller- and larger-magnitude events (lower b-value) than for the prior events in the area. Aftershock rates generally decreased with time through August but there was a noteworthy 5.8-day hiatus in activity that began 37 hours after the collapse. The University of Utah deployed a 5-station temporary network near the mine beginning on 8 Aug. Data from these stations are being used to help develop travel-time corrections for these and other stations in order to improve the computed locations of seismic events that occurred in the area both before and after the 6 Aug collapse.

Investigation of a Neurocognitive Biomarker and of Methods to Mitigate Biases in Cognitive/Perceptual/Emotional Processing

DTIC Science & Technology

2016-03-03

UU UU 03-03-2016 5-Aug-2013 4-Aug-2014 Final Report: Investigation of a Neurocognitive Biomarker and of Methods to Mitigate Biases in Cognitive ...ADDRESS (ES) U.S. Army Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 Hemispheric activity, Lateralization, Cognition , fNIRS...Papers published in non peer-reviewed journals: Final Report: Investigation of a Neurocognitive Biomarker and of Methods to Mitigate Biases in Cognitive

Semiannual Technical Summary, 1 April-30 September 1993

DTIC Science & Technology

1993-12-01

Hardware failure 11 Jul 2200 - Hardware failure 12 Jul - 0531 Hardware failure 12 Jul 0744 - 1307 Hardware service 1OAug 0821 - 1514 Line failure 29 Aug...1000 - Line failure 30 Aug - 1211 Line failure 08 Sep 1518 - Line failure 09 Sep - 0428 Line failure 10 Sep 0821 - 1030 Hardware failure 18 Sep 0817...reair. Between 8 September 1306 hrs and 9 September 0428 hre all communications systems wene affected (13.5 hrs). Reduced 01B performance started 10

Statistical Analyses of Marine Mammal Occurrence, Habitat Associations and Interactions with Ocean Dynamic Features

DTIC Science & Technology

2006-03-30

Sirena campaigns) have been successfully conducted in the northwestern Mediterranean Sea since 1999. Six sea trials have been conducted in the...trials ( Sirena campaigns) have been successfully conducted in the northwestern Mediterranean Sea since 1999. Six sea trials have been conducted in the...oceanographic measurements in the canyon region. 3-13 Aug 22 Aug- 6 Sep󈧏 23 Sep - 7 Oct ,- Figure 1: Sirena Sea Trials: yearly multi-platform at-sea

Stochastic Control Theory, Nonlinear Structural Mechanics and Applied Combinatorics

DTIC Science & Technology

1989-05-12

University LONG-TER11I VISITORS IN RESIDENCE One Month or More Assmus, Edward Lehigh University May I - Jun 30 Averbuch, Amir Tel Aviv University Jun 26 - Aug...Bryn Mawr May 1 - Jun 25 Lemke, Paul Rensselaer Polytechnic Institute Sep 14 - Jun 25 Lin, Shao-Shiung National Taiwan University Jun 15 - Aug 30 van ...25 Job, Vanessa University of Illinois, Chicago Jun 13 - 25 Jungnickel, D. Justus-Liebig University May 29 - Jun 24 Kacker, Raghu National Bureau

Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury

DTIC Science & Technology

2018-02-01

Vanessa M. Morales-Tirado MS, PhD CONTRACTING ORGANIZATION: University of Tennessee Health Science Center Memphis, TN 38163 REPORT DATE: February...which are critical for the visual output from the eye to the brain in health and ocular injury. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17...February 2018 15Aug2012 - 14Aug2015 Dr. Vanessa Morales vmorale1@uthsc.edu University of Tennessee Health Science Center Memphis, TN 38163 W81XWH

Army Pacific Pathways: Comprehensive Assessment and Planning Needed to Capture Benefits Relative to Costs and Enhance Value for Participating Units

DTIC Science & Technology

2016-11-01

Force and Number of Personnela Exercises 14 Aug. – Nov. 2014 2-2 Stryker Brigade Combat Team (BCT) ~820 personnel Keris Strike ( Malaysia ... Malaysia ) 15-3 June-July, Aug. – Nov. 2015 1-25 Stryker BCT ~420 personnel Khan Quest (Mongolia) Orient Shield (Japan) Hoguk (South Korea...Sept. 2016 2-2 Stryker BCT ~700 personnel Hanuman Guardian (Thailand) Salaknib (Philippines) Garuda Shield (Indonesia) Keris Strike ( Malaysia

East Europe Report, Political, Sociological and Military Affairs.

DTIC Science & Technology

1984-10-10

Budapest POLITIKAI FOISKOLA KOZLEMENYEI in Hungarian No 4, 1983, pp 17-18 [Article by Gabor Fodor: "Consensus and Youth"] [Excerpt] The confusion is...Planning Employee Numbers Budapest FIGYELO in Hungarian 9 Aug 84 p 7 [Article by tes: "Hopeless Hopes"] [Text] I wonder what kind of work force planning...to last year’s is counted on everywhere. Filling High-Skill Jobs Budapest NEPSZABADSAG in Hungarian 15 Aug 84 p 5 [Article by Laszlo Bakos

NASA Provides Coast-to-Coast Coverage of Aug. 21 Solar Eclipse (NASA Gulfstream III Aircraft, Off Oregon Coast)

NASA Image and Video Library

2017-08-21

On Monday, Aug. 21, NASA provided coast-to-coast coverage of the solar eclipse across America – featuring views of the phenomenon from unique vantage points, including from the ground, from aircraft, and from spacecraft including the ISS, during a live broadcast seen on NASA Television and the agency’s website. This is footage from NASA’s Gulfstream III research aircraft, flying off the Coast of Oregon.

Astronaut Jack Lousma participates in EVA to deploy twin pole solar shield

NASA Image and Video Library

1973-08-06

SL3-115-1833 (6 Aug. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, participates in the Aug. 6, 1973, extravehicular activity (EVA) during which he and astronaut Owen K. Garriott, science pilot, deployed the twin pole solar shield to help shade the Orbital Workshop (OWS). Note the striking reflection of the Earth in Lousma?s helmet visor. This photograph was taken with a 70mm hand-held Hasselblad camera. Photo credit: NASA

JPRS Report, East Europe.

DTIC Science & Technology

1992-09-18

AND LA W supplement) in Polish 13 Aug 92 p VII [Article by lawyer Piotr Miodowski: "The Small Consti- tution: Revelatory, Compromising, or a...waived or replaced with a new constitution. Assessment of Claims Filed Against Iraq 92EP0648A Warsaw RZECZPOSPOLITA (ECONOMY AND LA W supplement...11.8 8.6 12.6 16 Finance Official on Importance of Wage Tax 92EP0637A Warsaw RZECZPOSPOLITA (ECONOMY AND LA W supplement) in Polish 6 Aug 92 p VIII

Use of Wind Profiler Data in Short-Range Forecasting

DTIC Science & Technology

1994-01-15

predicted in this case. 40 WxP orolys~s foZ A AU)G 92 \\~~5 6-6 2 8 )Bo $6 76 ez 7 -’~ .’~ 𔃻~ 639 tit~ 7 0 61 2 12 66 6 6123 6 f AUG 09 , 1 1O1I 4 21 map...derived from the profiler network to the NGM fields. The software can animate a time series of the analyses, both for horizontal and vertical cross sections

View of Crewmembers in the SM during STS-118/Expedition 15 Farewell Ceremony

NASA Image and Video Library

2007-08-18

S118-E-09187 (18 Aug. 2007) --- The STS-118 and Expedition 15 crews gather for a farewell ceremony in the Zvezda Service Module of the International Space Station. Pictured are astronauts Barbara R. Morgan (foreground), Tracy Caldwell (left) and Rick Mastracchio, all STS-118 mission specialists; along with Scott Kelly (right), STS-118 commander. Hatches were closed between the station and Space Shuttle Endeavour at 4:10 p.m. on Aug. 18.

RF Environment Sensing Using Transceivers in Motion

DTIC Science & Technology

2014-05-02

NUMBER 5b. GRANT NUMBER 5a. CONTRACT NUMBER Form Approved OMB NO. 0704-0188 3. DATES COVERED (From - To) - UU UU UU UU 02-05-2014 3-Aug-2012 2-Aug...Crossing Information in Wireless Networks, 2013 IEEE Global Conference on Signal and Information Processing. 03-DEC-13, . : , Dustin Maas, Joey Wilson...transceivers may be required to cover the entire monitored area. Second, and very importantly, there may not be sufficient time to deploy a large number of

West Europe Report Tables of Contents JPRS-WER-86-064, 2 July 1986 JPRS-WER-86-124, 31 Dec 1986.

DTIC Science & Technology

1987-03-30

Exercise (Lars Porne ; SVENSKA DAGBLADET, 13 May 86) 59 Defense Research Institute To Study Officer Drain Causes (Richard Aschberg; SVENSKA DAGBLADET...DAGENS NYHETER, 8 Jun 86) 67 Entire Harsfjarden To Be Blocked With Nets To Halt Subs (Lars Porne ; SVENSKA DAGBLADET, 30 May 86) 72 Private Group...Fundamentalists Abroad Disagree on Ideology (HURRIYET, 20 Aug 86) 49 Fundamentalist Propaganda in Greeting Cards, Videos (HURRIYET, 16 Aug 86

JPRS Report, Science & Technology, China.

DTIC Science & Technology

1992-10-29

JISUANJI SHIJIE, 9 Sep 92] 37 Study on Recognition of Isolated Chinese Syllables by Neural Nets [Yang Shulin, Ke Youan, et al; DIANZI XUEBAO, Aug...KONGJIAN KEXUE JISHU, No 4, Aug 92] 16 A Study on SPF Technology for Thin Corrugated Plate of TB2 Titanium Alloy [Kan Guoli; ZHONGGUO KONGJIAN KEXUE...ZHONGGUO KEXUE BAO, 1 Sep 92] 3Q Structure Study of Nanometer-Size Crystalline Ti Films [Wu Xuemei, Wu Qinchong, et al; WULI XUEBAO, Jul 92] , 30

USMA Foreign Cadet Program -- A Case Study

DTIC Science & Technology

1981-05-04

USMA 1920) -- Garcia (USMA 1923) -- Gepte (USMA 1940) 7 13 ’!f -II - many served in significant national roles, e.g.: -- several in the creation and...PMA. He was to be followed as Super-Iintendent by Colonel Rafael Garcia , another Filipino USMA graduate (USMA 1916). In December 1941, with the...1915 3. Rafael Garcia 1916 4. Louis Salvosa Apr 1917 5. Fidel Segundo Aug 1917 6. Salvador Reyes Aug 1917 7. Eustaquio Baclig Nov 1918 8. Pastor

Non-Indigenous Marine Species (NIMS) in Biofouling on RAN Vessels: Threat Analysis

DTIC Science & Technology

2015-09-01

zebra Dechaineux (Nov 2001) & (Aug 2003) First recorded at Botany Bay in 1998 Metopograpsus messor Sydney (Aug 2003) Not recorded Pachygrapsus...Wollongong, Port Botany and Port Kembla) (Pollard and Pethebridge, 2002b). M. rosa has been designated as an Introduced Marine Pest (IMP) by the National... Botany Bay, NSW in 1990 (Lewis et al., 2006), and is known to co- occur with S. taeniatus, a species common along the eastern Australian coastline

JPRS Report, Science & Technology, China.

DTIC Science & Technology

1992-11-18

LPS O-Antigen Genes in E. coli HB101 40091002L Beijing YICHUAN XUEBAO fACTA GENETICA SINICA] in Chinese Vol 19 No 4, Aug 92 pp 378-384 [English...Isolation of Vitamine B2 Auxotroph and Preliminary Genetic Mapping in Salmonella typhimurium 40091002J Beijing YICHUAN XUEBAO [ACTA GENETICA SINICA] in...YICHUAN XUEBAO [ACTA GENETICA SINICA] in Chinese Vol 19 No 4, Aug 92 pp 369-377 [English abstract of article by Hai Weili [3189 0251 0500] and

NASA Satellite View of Tropical Storm Isaac

NASA Image and Video Library

2017-12-08

NASA's Terra satellite passed over Tropical Storm Isaac on Aug. 24 at 15:20 UTC (11:20 a.m. EDT) as it continued moving through the eastern Caribbean Sea. The MODIS instrument onboard Aqua captured this visible image. At 2 p.m. EDT on Aug. 24, Isaac's maximum sustained winds were near 60 mph (95 kmh). The National Hurricane Center noted that Isaac could strengthen later before reaching the coast of Hispaniola tonight, Aug. 24. Hispaniola is an island that contains the Dominican Republic and Haiti. Isaac is located about 135 miles (215 km) south-southeast of Port au Prince, Haiti, near latitude 16.8 north and longitude 71.4 west. Isaac is now moving toward the northwest near 14 mph (22 kmh). Isaac is expected to reach hurricane status over the weekend of Aug. 25-26 and NASA satellites will continue providing valuable temperature, rainfall, visible and infrared data. Text Credit: Rob Gutro NASA's Goddard Space Flight Center, Greenbelt, Md. To read more go to: www.nasa.gov/mission_pages/hurricanes/archives/2012/h2012... Credit: NASA Goddard MODIS Rapid Response Team NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Revisit the landscape of protonated water clusters H+(H2O)n with n = 10-17: An ab initio global search.

PubMed

Shi, Ruili; Li, Keyao; Su, Yan; Tang, Lingli; Huang, Xiaoming; Sai, Linwei; Zhao, Jijun

2018-05-07

Using a genetic algorithm incorporated with density functional theory, we explore the ground state structures of protonated water clusters H + (H 2 O) n with n = 10-17. Then we re-optimize the isomers at B97-D/aug-cc-pVDZ level of theory. The extra proton connects with a H 2 O molecule to form a H 3 O + ion in all H + (H 2 O) 10-17 clusters. The lowest-energy structures adopt a monocage form at n = 10-16 and core-shell structure at n = 17 based on the MP2/aug-cc-pVTZ//B97-D/aug-cc-pVDZ+ZPE single-point-energy calculation. Using second-order vibrational perturbation theory, we further calculate the infrared spectra with anharmonic correction for the ground state structures of H + (H 2 O) 10-17 clusters at the PBE0/aug-cc-pVDZ level. The anharmonic correction to the spectra is crucial since it reproduces the experimental results quite well. The extra proton weakens the O-H bond strength in the H 3 O + ion since the Wiberg bond order of the O-H bond in the H 3 O + ion is smaller than that in H 2 O molecules, which causes a red shift of the O-H stretching mode in the H 3 O + ion.

Revisit the landscape of protonated water clusters H+(H2O)n with n = 10-17: An ab initio global search

NASA Astrophysics Data System (ADS)

Shi, Ruili; Li, Keyao; Su, Yan; Tang, Lingli; Huang, Xiaoming; Sai, Linwei; Zhao, Jijun

2018-05-01

Using a genetic algorithm incorporated with density functional theory, we explore the ground state structures of protonated water clusters H+(H2O)n with n = 10-17. Then we re-optimize the isomers at B97-D/aug-cc-pVDZ level of theory. The extra proton connects with a H2O molecule to form a H3O+ ion in all H+(H2O)10-17 clusters. The lowest-energy structures adopt a monocage form at n = 10-16 and core-shell structure at n = 17 based on the MP2/aug-cc-pVTZ//B97-D/aug-cc-pVDZ+ZPE single-point-energy calculation. Using second-order vibrational perturbation theory, we further calculate the infrared spectra with anharmonic correction for the ground state structures of H+(H2O)10-17 clusters at the PBE0/aug-cc-pVDZ level. The anharmonic correction to the spectra is crucial since it reproduces the experimental results quite well. The extra proton weakens the O-H bond strength in the H3O+ ion since the Wiberg bond order of the O-H bond in the H3O+ ion is smaller than that in H2O molecules, which causes a red shift of the O-H stretching mode in the H3O+ ion.

Energetic-ion acceleration and transport in the upstream region of Jupiter: Voyager 1 and 2

NASA Technical Reports Server (NTRS)

Baker, D. N.; Zwickl, R. D.; Carbary, J. F.; Krimigis, S. M.; Lepping, R. P.

1982-01-01

Long-lived upstream energetic ion events at Jupiter appear to be very similar in nearly all respects to upstream ion events at Earth. A notable difference between the two planetary systems is the enhanced heavy ion compositional signature reported for the Jovian events. This compositional feature has suggested that ions escaping from the Jovian magnetosphere play an important role in forming upstream ion populations at Jupiter. In contrast, models of energetic upstream ions at Earth emphasize in situ acceleration of reflected solar wind ions within the upstream region itself. Using Voyager 1 and 2 energetic ( approximately 30 keV) ion measurements near the magnetopause, in the magnetosheath, and immediately upstream of the bow shock, the compositional patterns are examined together with typical energy spectra in each of these regions. A model involving upstream Fermi acceleration early in events and emphasizing energetic particle escape in the prenoon part of the Jovian magnetosphere late in events is presented to explain many of the features in the upstream region of Jupiter.

Benchmark calculations with correlated molecular wavefunctions. XIII. Potential energy curves for He2, Ne2 and Ar2 using correlation consistent basis sets through augmented sextuple zeta

NASA Astrophysics Data System (ADS)

van Mourik, Tanja

1999-02-01

The potential energy curves of the rare gas dimers He2, Ne2, and Ar2 have been computed using correlation consistent basis sets ranging from singly augmented aug-cc-pVDZ sets through triply augmented t-aug-cc-pV6Z sets, with the augmented sextuple basis sets being reported herein. Several methods for including electron correlation were investigated, namely Moller-Plesset perturbation theory (MP2, MP3 and MP4) and coupled cluster theory [CCSD and CCSD(T)]. For He2CCSD(T)/d-aug-cc-pV6Z calculations yield a well depth of 7.35cm-1 (10.58K), with an estimated complete basis set (CBS) limit of 7.40cm-1 (10.65K). The latter is smaller than the 'exact' well depth (Aziz, R. A., Janzen, A. R., and Moldover, M. R., 1995, Phys. Rev. Lett., 74, 1586) by about 0.2cm-1 (0.35K). The Ne well depth, computed with the CCSD(T)/d-aug-cc-pV6Z method, is 28.31cm-1 and the estimated CBS limit is 28.4cm-1, approximately 1cm-1 smaller than the empirical potential of Aziz, R. A., and Slaman, M., J., 1989, Chem. Phys., 130, 187. Inclusion of core and core-valence correlation effects has a negligible effect on the Ne well depth, decreasing it by only 0.04cm-1. For Ar2, CCSD(T)/ d-aug-cc-pV6Z calculations yield a well depth of 96.2cm-1. The corresponding HFDID potential of Aziz, R. A., 1993, J. chem. Phys., 99, 4518 predicts of D of 99.7cm-1. Inclusion of core and core-valence effects in Ar increases the well depth and decreases the discrepancy by approximately 1cm-1.

Structures and electron affinity of XO30,-, XOF40,- and XO2F20,- (X = P, As, Sb, Bi): a theoretical study of novel superhalogen formulae and exceptions of superhalogen formulae

NASA Astrophysics Data System (ADS)

Yang, Yi-Fan; Cui, Zhong-Hua; Ding, Yi-Hong

2015-03-01

Most superhalogen species are in the form of oxides or halides. To enrich the family of superhalogen species, herein, we investigated the structures and electron affinity (EA) values of higher group 15 elements (X = P, As, Sb, Bi) oxyfluoride species XO30,-, XOF40,- and XO2F20,-, at the CCSD(T)/aug-cc-pVTZ-pp & aug-cc-pVTZ //B3LYP/aug-cc-pVTZ-pp & aug-cc-pVTZ levels (aug-cc-pVTZ-pp for X = Sb and Bi). Some oxyfluoride species, i.e., PO2F20,-, AsO2F20,-, SbO2F20,-, POF40,-, AsOF40,-, SbOF40,- and BiOF40,-, were found to possess higher EA (VDE: 5.0-6.2 eV; ADE: 4.5-5.5 eV) than halogens (F: 3.4 eV; Cl: 3.6 eV). Thus, we recommended that the oxyfluorides in the form of XO2F20,- and XOF40,- should be considered as potential superhalogens, which have not been considered previously. Surprisingly, we showed that BiO3 and BiO2F2, in superhalogen formulae, possess a high vertical detachment energy (VDE) yet a low adiabatic detachment energy (ADE). This is in marked contrast to the previously reported superhalogens, which generally contain both the high VDE and high ADE values. It is the first report about exceptions of superhalogen formulae. These findings revealed that for the analogous main-group compounds with the same structural formula, the difference in the metallic property of the core element could lead to the significant difference in the ground structures of either the anionic or neutral structures, which would result in the much differed superhalogen features.

Evaluation of B3LYP, X3LYP, and M06-Class Density Functionals for Predicting the Binding Energies of Neutral, Protonated, and Deprotonated Water Clusters.

PubMed

Bryantsev, Vyacheslav S; Diallo, Mamadou S; van Duin, Adri C T; Goddard, William A

2009-04-14

In this paper we assess the accuracy of the B3LYP, X3LYP, and newly developed M06-L, M06-2X, and M06 functionals to predict the binding energies of neutral and charged water clusters including (H2O)n, n = 2-8, 20), H3O(+)(H2O)n, n = 1-6, and OH(-)(H2O)n, n = 1-6. We also compare the predicted energies of two ion hydration and neutralization reactions on the basis of the calculated binding energies. In all cases, we use as benchmarks calculated binding energies of water clusters extrapolated to the complete basis set limit of the second-order Møller-Plesset perturbation theory with the effects of higher order correlation estimated at the coupled-cluster theory with single, double, and perturbative triple excitations in the aug-cc-pVDZ basis set. We rank the accuracy of the functionals on the basis of the mean unsigned error (MUE) between calculated benchmark and density functional theory energies. The corresponding MUE (kcal/mol) for each functional is listed in parentheses. We find that M06-L (0.73) and M06 (0.84) give the most accurate binding energies using very extended basis sets such as aug-cc-pV5Z. For more affordable basis sets, the best methods for predicting the binding energies of water clusters are M06-L/aug-cc-pVTZ (1.24), B3LYP/6-311++G(2d,2p) (1.29), and M06/aug-cc-PVTZ (1.33). M06-L/aug-cc-pVTZ also gives more accurate energies for the neutralization reactions (1.38), whereas B3LYP/6-311++G(2d,2p) gives more accurate energies for the ion hydration reactions (1.69).

On the accuracy of explicitly correlated methods to generate potential energy surfaces for scattering calculations and clustering: application to the HCl-He complex.

PubMed

Ajili, Yosra; Hammami, Kamel; Jaidane, Nejm Eddine; Lanza, Mathieu; Kalugina, Yulia N; Lique, François; Hochlaf, Majdi

2013-07-07

We closely compare the accuracy of multidimensional potential energy surfaces (PESs) generated by the recently developed explicitly correlated coupled cluster (CCSD(T)-F12) methods in connection with the cc-pVXZ-F12 (X = D, T) and aug-cc-pVTZ basis sets and those deduced using the well-established orbital-based coupled cluster techniques employing correlation consistent atomic basis sets (aug-cc-pVXZ, X = T, Q, 5) and extrapolated to the complete basis set (CBS) limit. This work is performed on the benchmark rare gas-hydrogen halide interaction (HCl-He) system. These PESs are then incorporated into quantum close-coupling scattering dynamical calculations in order to check the impact of the accuracy of the PES on the scattering calculations. For this system, we deduced inelastic collisional data including (de-)excitation collisional and pressure broadening cross sections. Our work shows that the CCSD(T)-F12/aug-cc-pVTZ PES describes correctly the repulsive wall, the van der Waals minimum and long range internuclear distances whereas cc-pVXZ-F12 (X = D,T) basis sets are not diffuse enough for that purposes. Interestingly, the collision cross sections deduced from the CCSD(T)-F12/aug-cc-pVTZ PES are in excellent agreement with those obtained with CCSD(T)/CBS methodology. The position of the resonances and the general shape of these cross sections almost coincide. Since the cost of the electronic structure computations is reduced by several orders of magnitude when using CCSD(T)-F12/aug-cc-pVTZ compared to CCSD(T)/CBS methodology, this approach can be recommended as an alternative for generation of PESs of molecular clusters and for the interpretation of accurate scattering experiments as well as for a wide production of collisional data to be included in astrophysical and atmospherical models.

ONIOM Study of Chemical Reactions in Microsolvation Clusters: (H2O)(n)CH3Cl+OH-(H2O)(m) (n+m = 1 and 2)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Re, Suyong; Morokuma, Keiji

2001-07-07

The reliability of the two-layered ONIOM (our own N-layered molecular orbital + molecular mechanics) method was examined for the investigation of the SN2 reaction pathway (reactants, reactant complexes, transition states, product complexes, and products) between CH3Cl and an OH- ion in microsolvation clusters with one or two water molecules. Only the solute part, CH3Cl and OH-, was treated at a high level of molecular orbital (MO) theory, and all solvent water molecules were treated at a low MO level. The ONIOM calculation at the MP2 (Moller-Plesset second order perturbation)/aug-cc-pVDZ (augmented correlation-consistent polarized valence double-zeta basis set) level of theory asmore » the high level coupled with the B3LYP (Becke 3 parameter-Lee-Yag-Parr)/6-31+G(d) as the low level was found to reasonably reproduce the "target"geometries at the MP2/aug-cc-pVDZ level of theory. The energetics can be further improved to an average absolute error of <1.0 kcal/mol per solvent water molecule relative to the target CCSD(T) (coupled cluster singles and doubles with triples by perturbation)/aug-cc-pVDZ level by using the ONIOM method in which the high level was CCSD(T)/aug-cc-pVDZ level with the low level of MP2/aug-cc-pVDZ. The present results indicate that the ONIOM method would be a powerful tool for obtaining reliable geometries and energetics for chemical reactions in larger microsolvated clusters with a fraction of cost of the full high level calculation, when an appropriate combination of high and low level methods is used. The importance of a careful test is emphasized.« less

McClellan AFB, California, RI/FS Quality Assurance Project Plan. Installation Restoration Program (IRP) Stage 3.

DTIC Science & Technology

1992-08-07

AD-A5 6 ... 1... . .. .. .... INSTALLATION RESTORATION PROGRAM (IRP) STAGE 3 7m~ QUALITY ASSURANCE -k- PROJECT PLAN for McCLELLAN AFB , CALIFORNIA...FINAL.. S AUG 2. 1 1992 L PREPARED FOR: .... ... McCLELLAN AFB IEM McCLELLAN AFB , CALIFORNIA 9652-599 ................... fr pu licrele se...PLAN FINAL ’’ : " FOR McCLELLAN AFB /EM McCLELLAN AFB , CALIFORNIA 95652-5990 August 1992 AUG 2 11992 PREPARED BY: DI Radian Corporation10389 Old

User Guide: How to Use and Operate Virtual Reality Equipment in the Systems Assessment and Usability Laboratory (SAUL) for Conducting Demonstrations

DTIC Science & Technology

2017-08-01

ARL-TN-0839 ● AUG 2017 US Army Research Laboratory User Guide: How to Use and Operate Virtual Reality Equipment in the Systems...ARL-TN-0839 ● AUG 2017 US Army Research Laboratory User Guide: How to Use and Operate Virtual Reality Equipment in the Systems...September 2017 4. TITLE AND SUBTITLE User Guide: How to Use and Operate Virtual Reality Equipment in the Systems Assessment and Usability Laboratory

SKYLAB (SL)-3 - TELEVISION (EXTRAVEHICULAR ACTIVITY [EVA])

NASA Image and Video Library

1973-08-27

S73-33161 (24 Aug. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, hooks up a 23-foot, two-inch connecting cable for the rate gyro six pack during extravehicular activity (EVA) on Aug. 24, 1973, as seen in this photographic reproduction taken from a color television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The rate gyros were mounted inside the Multiple Docking Adapter opposite the Apollo Telescope Mount control and display console. Photo credit: NASA

Investigating the Mobility of Light Autonoumous Tracked Vehicles Using a High Performance Computing Simulation Capability

DTIC Science & Technology

2012-08-01

UNCLASSIFIED: Distribution Statement A. Approved for public release. DISCLAIMER: Reference herein to any specific commercial company , product...FunctionBay, S. Korea – NVIDIA – Caterpillar – MSC.Software – Advanced Micro Devices (AMD) 14-16 AUG 2012  Aaron Bartholomew  Makarand Datar...16GB DDR2 Graphics: 4x NVIDIA Tesla C1060 Power supply 1: 1000W Power supply 2: 750W Assembled Quad GPU Machine 14-16 AUG 2012 30

Solar sphere viewed through the Skylab solar physics experiment

NASA Image and Video Library

1973-08-21

S73-32867 (21 Aug. 1973) --- The solar sphere viewed through the Skylab solar physics experiment (S082) Extreme Ultraviolet Spectroheliographis seen in this photographic reproduction taken from a color television transmission made by a TV camera aboard the Skylab space station in Earth orbit. The solar chromosphere and lower corona are much hotter than the surface of the sun characterized by the white light emissions. This image was recorded during the huge solar prominence which occurred on Aug. 21, 1973. Photo credit: NASA

Single-Walled Carbon Nanotubes Targeted to the Tumor Vasculature for Breast Cancer Treatment

DTIC Science & Technology

2009-09-01

using 1 -ethyl- 3 -[ dimethylaminopropyl ]carbodiimide hydrochloride (EDC). The binding of SWNT-annexin V to PS will be measured using PS immobilized on...ADDRESS. 1 . REPORT DATE (DD-MM-YYYY) -09-200 2. REPORT TYPE Final 3 . DATES COVERED (From - To) 16 Aug 2007 – 15 Aug 2009 4. TITLE AND SUBTITLE...Conjugation of Annexin V to SWNTs Using the Linker Fluorenylmethoxycarbonyl (Fmoc)-amine-PEG-succinimidyl Carboxy Methyl Ester 1 . Add 3 mg of SWNTs to 7

The Space Shuttle Discovery, atop a specially modified Boeing 747

NASA Image and Video Library

2005-08-21

JSC2005-E-36604 (21 August 2005) --- The Space Shuttle Discovery, atop a specially modified Boeing 747, was photographed following touch down at NASA Kennedy Space Center’s (KSC) Shuttle Landing Facility on Aug. 21, 2005 after a ferry flight from Edwards Air Force Base in California, where the shuttle landed Aug. 9. The 747, known as the Shuttle Carrier Aircraft (SCA), brought Discovery home to KSC after completing the historic STS-114 Return to Flight mission.

Translations on North Korea, Number 563

DTIC Science & Technology

1977-11-29

units are subordinate to the Unit to Which Comrade Kim ;e"J°\\S *elonf £nit leader Kim Yong - ung ) : The Triple Red Banner Unit to Which Comrade...No. 563 CONTENTS PAGE Development and Prosperity of Anju Described (Sonu Song-ok; MINJU CHOSON, 30 Aug 77) 1 Kim and Pak Receive Reply From GDR...CHOSON in Korean 30 Aug 77 p 4 [Article by Sonu Song-ok: "Anju Thriving With New Life"] [Text] The respected and beloved leader Comrade Kim Il

Global Explosive Ordnance Disposal Conference and Exhibition Held in Fort Walton Beach, Florida on April 27-30, 2010

DTIC Science & Technology

2010-04-30

POLICY 24 Kagan ASP Response  21 Jul 08- ARCENT notified by Defense Attaché .  Uzbeks requested three types of equipment: land mine detectors...2 pax) on site.  21 Aug 08- the Training Team (5 pax) with equipment arrived in Uzbekistan.  28 Aug 08 all Uzbek / USEMB objectives were met...Slovakia, Spain, Poland Romania, United Kingdom, United States, Turkey Albania, Croatia Czech Republic, Hungary, Iceland, Czech Latvia, Lithuania

Economic Indicators Selected Countries.

DTIC Science & Technology

1987-12-01

Earnings of all 1982 1986 7.4 Male Employees (a) Aug 1986 Aug 1987 4.8 Hourly Wace Rates 3 1979 1987 lt.2 Garden Island 1983 1987 6.7 Dockyards Dec...Canaca Hourly Earnings 24 1978 1986 7.2 in Manufacturing 1982 1986 3.9 Jun 1986 jun 1987 2.3 (a) As from September 1981, the method of compiling...average weekly earnings estimates has changed. Long term escalation rates are based on the old series. (u) As from January 1985, the method of compiling

Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

DTIC Science & Technology

2015-11-01

AWARD NUMBER: W81XWH-13-1-0139 TITLE: Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined...DATES COVERED 15Aug2013 - 14Aug2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-13-1-0139 Targeting Common but Complex Proteoglycans on...outbreaks in epidemic regions of the world. Prior to this application we discovered that human breast cancer cells express this same carbohydrate

Idaho Wildfire Imaged by NASA's Terra Spacecraft

NASA Image and Video Library

2017-08-14

A wildfire burned 46,000 acres southwest of Pocatello, Idaho, threatening homes and filling the area with smoke. The human-caused fire was 85 percent contained by Aug. 10, 2017. The extent of the burned area is evident in this image as the dark gray area. The image was acquired Aug. 13, 2017, covers an area of 22 by 28 miles (36 by 45 kilometers), and is located at 42.7 degrees north, 112.6 degrees west. https://photojournal.jpl.nasa.gov/catalog/PIA21875

2005 Tri-Service Infrastructure Systems Conference and Exhibition. Volume 2, Track 2

DTIC Science & Technology

2005-08-04

not produce toxic by-products, including: – UV – E-Beam – Pulsed Corona Discharge R&D Simulation of Fate & Transport of a CB Agent in a Water...Nationwide network of sensors with integration with ASOCC or CATS . – CHPPM - Soldier health, sensors, and fate of agent. – Congressional line-item with Hach...west Nile virus ), birds (avian flu) Public meeting Aug 10. Construction start ~ late Aug – early Sep pending signed MOA P & S complete, some

JPRS Report, Near East and South Asia.

DTIC Science & Technology

1990-10-17

Workers Reduced, Economy Hit [THE NEW NATION 25 AugJ 7 Mideast Crisis Effects on Bangladesh Economy Discussed [THE BANGLADESH OBSERVER 26 AugJ 8...must be removed. In the past the question was asked more than once, whether the removal of one leader could change the behavior of a state and its...economy will suffer a severe jolt and this will have a far reaching effect , they said. SOUTH ASIA JPRS-NEA-90-059 17 OCTOBER 1990 An official of the

Determining the Location of DNA Modification and Mutation Caused by UVB Light in Skin Cancer

DTIC Science & Technology

2015-09-01

Award Number: W81XWH-12-1-0333 TITLE: Determining the Location of DNA Modification and Mutation Caused by UVB Light in Skin Cancer PRINCIPAL...COVERED 15 Aug 2012 – 14 Aug 2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-12-1-0333 Determining the Location of DNA Modification and Mutation ...sequencing libraries generated for both yeast and human cells show pyrimidine bias on the 5’ end, indicating that we are sequencing the dimers

A Partial Least Squares Based Procedure for Upstream Sequence Classification in Prokaryotes.

PubMed

Mehmood, Tahir; Bohlin, Jon; Snipen, Lars

2015-01-01

The upstream region of coding genes is important for several reasons, for instance locating transcription factor, binding sites, and start site initiation in genomic DNA. Motivated by a recently conducted study, where multivariate approach was successfully applied to coding sequence modeling, we have introduced a partial least squares (PLS) based procedure for the classification of true upstream prokaryotic sequence from background upstream sequence. The upstream sequences of conserved coding genes over genomes were considered in analysis, where conserved coding genes were found by using pan-genomics concept for each considered prokaryotic species. PLS uses position specific scoring matrix (PSSM) to study the characteristics of upstream region. Results obtained by PLS based method were compared with Gini importance of random forest (RF) and support vector machine (SVM), which is much used method for sequence classification. The upstream sequence classification performance was evaluated by using cross validation, and suggested approach identifies prokaryotic upstream region significantly better to RF (p-value < 0.01) and SVM (p-value < 0.01). Further, the proposed method also produced results that concurred with known biological characteristics of the upstream region.

Interfacial kinetics in nanosized Au/Ge films: An in situ TEM study

NASA Astrophysics Data System (ADS)

Kryshtal, Aleksandr P.; Minenkov, Alexey A.; Ferreira, Paulo J.

2017-07-01

We investigate the morphology and crystalline structure of Au/Ge films in a wide range of temperatures by in situ TEM heating. Au/Ge films with Au mass thickness of 0.2-0.3 nm and Ge thickness of 5 nm were produced in vacuum by the sequential deposition of components on a carbon substrate at room temperature. It has been shown that particles with an average size of 4 nm, formed by Au film de-wetting, melt on the germanium substrate at temperatures 110-160 °C, which are below the eutectic temperature for the bulk. The effect of crystallization-induced capillary motion of liquid eutectic particles over Ge surface has been found in this work. Formation of metastable fcc phase of Ge has been observed at the liquid-germanium interface and behind the moving particle. Formation of a liquid phase with its subsequent crystallization at the metal-semiconductor interface seems to play a key role in the metal-induced crystallization effect.

Sequential modelling of ICRF wave near RF fields and asymptotic RF sheaths description for AUG ICRF antennas

NASA Astrophysics Data System (ADS)

Jacquot, Jonathan; Tierens, Wouter; Zhang, Wei; Bobkov, Volodymyr; Colas, Laurent; Noterdaeme, Jean-Marie

2017-10-01

A sequence of simulations is performed with RAPLICASOL and SSWICH to compare two AUG ICRF antennas. RAPLICASOL outputs have been used as input to SSWICH-SW for the AUG ICRF antennas. Using parallel electric field maps and the scattering matrix produced by RAPLICASOL, SSWICH-SW, reduced to its asymptotic part, is able to produce a 2D radial/poloidal map of the DC plasma potential accounting for the antenna input settings (total power, power balance, phasing). Two models of antennas are compared: 2-strap antenna vs 3-strap antenna. The 2D DC potential structures are correlated to structures of the parallel electric field map for different phasing and power balance. The overall DC plasma potential on the 3-strap antenna is lower due to better global RF currents compensation. Spatial proximity between regions of high RF electric field and regions where high DC plasma potentials are observed is an important factor for sheath rectification.

Calculations of molecular multipole electric moments of a series of exo-insaturated four-membered heterocycles, Y = CCH2CH2X

NASA Astrophysics Data System (ADS)

Romero, Angel H.

2017-10-01

The influence of ring puckering angle on the multipole moments of sixteen four-membered heterocycles (1-16) was theoretically estimated using MP2 and different DFTs in combination with the 6-31+G(d,p) basis set. To obtain an accurate evaluation, CCSD/cc-pVDZ level and, the MP2 and PBE1PBE methods in combination with the aug-cc-pVDZ and aug-cc-pVTZ basis sets were performed on the planar geometries of 1-16. In general, the DFT and MP2 approaches provided an identical dependence of the electrical properties with the puckering angle for 1-16. Quantitatively, the quality of the level of theory and basis sets affects significant the predictions of the multipole moments, in particular for the heterocycles containing C=O and C=S bonds. Convergence basis sets within the MP2 and PBE1PBE approximations are reached in the dipole moment calculations when the aug-cc-pVTZ basis set is used, while the quadrupole and octupole moment computations require a larger basis set than aug-cc-pVTZ. On the other hand, the multipole moments showed a strong dependence with the molecular geometry and the nature of the carbon-heteroatom bonds. Specifically, the C-X bond determines the behavior of the μ(ϕ), θ(ϕ) and Ώ(ϕ) functions, while the C=Y bond plays an important role in the magnitude of the studied properties.

75 FR 68714 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-09

... mile +683 Village of Mayfield. upstream of Rogers Road. Chagrin River Approximately 40 feet +786 Village of Moreland upstream of Woodland Hills. Road. Approximately 1,200 feet +789 upstream of Woodland... Miles Road. Countrymans Creek Upstream of I-71......... +721 Village of Lindale. Downstream of Bellaire...

The 'upstream wake' of swimming and flying animals and its correlation with propulsive efficiency.

PubMed

Peng, Jifeng; Dabiri, John O

2008-08-01

The interaction between swimming and flying animals and their fluid environments generates downstream wake structures such as vortices. In most studies, the upstream flow in front of the animal is neglected. In this study, we demonstrate the existence of upstream fluid structures even though the upstream flow is quiescent or possesses a uniform incoming velocity. Using a computational model, the flow generated by a swimmer (an oscillating flexible plate) is simulated and a new fluid mechanical analysis is applied to the flow to identify the upstream fluid structures. These upstream structures show the exact portion of fluid that is going to interact with the swimmer. A mass flow rate is then defined based on the upstream structures, and a metric for propulsive efficiency is established using the mass flow rate and the kinematics of the swimmer. We propose that the unsteady mass flow rate defined by the upstream fluid structures can be used as a metric to measure and objectively compare the efficiency of locomotion in water and air.

Thinking Upstream: A 25-Year Retrospective and Conceptual Model Aimed at Reducing Health Inequities.

PubMed

Butterfield, Patricia G

Thinking upstream was first introduced into the nursing vernacular in 1990 with the goal of advancing broad and context-rich perspectives of health. Initially invoked as conceptual framing language, upstream precepts were subsequently adopted and adapted by a generation of thoughtful nursing scholars. Their work reduced health inequities by redirecting actions further up etiologic pathways and by emphasizing economic, political, and environmental health determinants. US health care reform has fostered a much broader adoption of upstream language in policy documents. This article includes a semantic exploration of thinking upstream and a new model, the Butterfield Upstream Model for Population Health (BUMP Health).

Analysis of key thresholds leading to upstream dependencies in global transboundary water bodies

NASA Astrophysics Data System (ADS)

Munia, Hafsa Ahmed; Guillaume, Joseph; Kummu, Matti; Mirumachi, Naho; Wada, Yoshihide

2017-04-01

Transboundary water bodies supply 60% of global fresh water flow and are home to about 1/3 of the world's population; creating hydrological, social and economic interdependencies between countries. Trade-offs between water users are delimited by certain thresholds, that, when crossed, result in changes in system behavior, often related to undesirable impacts. A wide variety of thresholds are potentially related to water availability and scarcity. Scarcity can occur because of the country's own water use, and that is potentially intensified by upstream water use. In general, increased water scarcity escalates the reliance on shared water resources, which increases interdependencies between riparian states. In this paper the upstream dependencies of global transboundary river basins are examined at the scale of sub-basin areas. We aim to assess how upstream water withdrawals cause changes in the scarcity categories, such that crossing thresholds is interpreted in terms of downstream dependency on upstream water availability. The thresholds are defined for different types of water availability on which a sub-basin relies: - reliable local runoff (available even in a dry year), - less reliable local water (available in the wet year), - reliable dry year inflows from possible upstream area, and - less reliable wet year inflows from upstream. Possible upstream withdrawals reduce available water downstream, influencing the latter two water availabilities. Upstream dependencies have then been categorized by comparing a sub-basin's scarcity category across different water availability types. When population (or water consumption) grows, the sub-basin satisfies its needs using less reliable water. Thus, the factors affecting the type of water availability being used are different not only for each type of dependency category, but also possibly for every sub- basin. Our results show that, in the case of stress (impacts from high use of water), in 104 (12%) sub- basins out of 886 sub-basins are dependent on upstream water, while in the case of shortage (impacts from insufficient water availability per person), 79 (9%) sub-basins out of 886 sub-basins dependent on upstream water. Categorization of the upstream dependency of the sub-basins helps to differentiate between areas where i) there is currently no dependency on upstream water, ii) upstream water withdrawals are sufficiently high that they alter the scarcity and dependency status, and iii) which are always dependent on upstream water regardless of upstream water withdrawals. Our dependency assessment is expected to considerably support the studies and discussions of hydro-political power relations and management practices in transboundary basins.

Earth Observation

NASA Image and Video Library

2014-08-23

ISS040-E-105768 (23 Aug. 2014) --- One of the Expedition 40 crew members aboard the International Space Station, flying at an altitude of 221 nautical miles, captured this image of Egypt's Nile River and Lake Nasser on Aug. 23, 2014. The Aswan High Dam is to the right of center in the 70mm focal-length image, as the Nile flows southward (to the right in this image) toward Cairo and it?s Mediterranean delta (both out of frame at right). The Red Sea, which runs more or less parallel to the Nile, is out of frame at bottom.

A User’s Guide to the Coastal Engineering Research Center’s (CERC’S) Field Research Facility.

DTIC Science & Technology

1985-05-01

7 PART I: INTRODUCTION ............. ......................... 8 Use of the FRF .......... ......................... 12 Description of... INTRODUCTION 1. Federal interest in coastal engineering began in the 1920’s as a result of the increasing shoreline erosion along the recreational...lower at the pier end. As waves move 70 i- .r, N . SURVEY INTERVALS DAYS Jul 1. 1961 Jul 17 Aug 4 jAug 24 1Sep 19 Now 3 ’o1 en a 16Apr21I Jun?. to to to

Impact of Assimilating Surface Velocity Observations on the Model Sea Surface Height Using the NCOM-4DVAR

DTIC Science & Technology

2016-09-26

statistical analysis is done by not only examining the SSH forecast error across the entire do- main, but also by concentrating on the areamost densely covered...over (b) entire GoM domain and (d) GLAD region only. Statistics shown for FR (thin black), SSH1 (thick black), and VEL (gray) experiment 96-h SSH...coefficient. To statistically FIG. 9. Sea surface height (m) for AVISO (a) 1 Aug, (b) 20 Aug, (c) 10 Sep, and (d) 30 Sep; for SSH1 experiment (e) 1

STS-85 Discovery OV-103 landing

NASA Image and Video Library

1997-08-19

STS085-S-014 (19 Aug. 1997) --- The main landing gear of the space shuttle Discovery touches down on Runway 33 at the Kennedy Space Center to mark the successful completion of 12-day STS-85 mission. Landing occurred at 7:08 a.m. (EDT) on Aug. 19, 1997. Onboard were astronauts Curtis L. Brown, mission commander; Kent V. Rominger, pilot; N. Jan Davis, payload commander; and Robert L. Curbeam and Stephen K. Robinson, both mission specialists; along with payload specialist Bjarni Tryggvason, representing the Canadian Space Agency. Photo credit: NASA

Air University Library Index to Military Periodicals, Volume 43, Number 3, July-September 1992,

DTIC Science & Technology

1992-09-01

CHAPMAN, Craig S., Maj Invisible art of camouflage. Murrav career path. Julius Hecm. Program Gull War: Nondeployed roundouts. illus flammick. illug...illus Government Executive 24 no 8 Senate Armed Services Committee 20 May CRAIG , CJS, Commo (Aug 󈨠): p,0-70+ 󈨠. Defense Issues 7 no 35 (󈨠): p1...Grier. illus tab. COOPERATION 󈨠):p 11-16 Governmemnt :Eze~ijve 24 no 8 (Aug 󈨠): C(X)TF, John, Capt, Ret CRAIG , David pI1 3 - 1 15 Submariner. hook

Fluoroolefins as Peptide Mimetics. 2. A Computational Study of the Conformational Ramifications of Peptide Bond Replacement

DTIC Science & Technology

2010-01-01

respectively. Conformations for all three systems were generated by exhaustive Monte Carlo searching. Relative conformational energies were calculated at the...routines of the Maestro(v. 6.5)/ Macromodel-Batchmin(8.6)21 suite of programs. The number of Monte Carlo steps for the searches was 500 000. Energy ...set using the B3LYP30,31 hybrid density functional. Single-point energies at the MP2/ aug-cc-pVDZ and MP2/aug-cc-pVTZ levels of theory were obtained

Astronaut Jack Lousma seen outside Skylab space station during EVA

NASA Image and Video Library

1973-08-06

S73-31976 (5 Aug. 1973) --- Astronaut Jack R. Lousma, Skylab 3 pilot, is seen outside the Skylab space station in Earth orbit during the Aug. 5, 1973 Skylab 3 extravehicular activity (EVA) in this photographic reproduction taken from a television transmission made by a color TV camera aboard the space station. Scientist-astronaut Owen K. Garriott, Skylab 3 science pilot, participated in the EVA with Lousma. During the EVA the two crewmen deployed the twin pole solar shield to help shade the Orbital Workshop. Photo credit: NASA

Cultural Resource Investigation of the Historic Fort Randall Post Cemetery, Gregory County, South Dakota.

DTIC Science & Technology

1986-01-01

cemetery: LOCATED BY SHOULD BE K GRAVE # GRAVE # Susana , wife of G Rieder 134 137 Died Feb 27, 1892 SINGLE STONE w, - Augustin, Infant Child of G and...134 134 Susana Rieder. Died Aug 3, 1881 Elizabeth A. Carroll 135 135 Jacob Herman 128 128 J.A. Breckenridge (Plate 8) 123 123 Lena, wife of J.F...Inf. June 24, 1859 32. Harting Daniel Pvt. Co. M, 4th U.S. Art. Aug. 1, 1859 33. Cummings, James Pvt. Co. A, Dak. Vols. Apr. 8, 1863 34

Spectroscopy of the novae M31N_2008-08a and M31N_2008-08b

NASA Astrophysics Data System (ADS)

Di Mille, F.; Ciroi, S.; Orio, M.; Rafanelli, P.; Bianchini, A.; Nelson, T.; Andreuzzi, G.

2008-09-01

We obtained low resolution spectra of the two optical nova candidates in M31 (see ATEL #1654). The spectra were obtained with the 3.5-m Telescopio Nazionale Galileo of INAF equipped with the DOLORES spectrograph and camera (spectral range 330-790 nm, resolution 1.2 nm) on Aug 17.13 for 2008-08a and on Aug 17.17 for 2008-08b (8 days after the discovery of both novae, which were below the detection limits 2 days earlier).

Targeted, On-Demand Charge Conversional Nanotherapeutics for Advanced Prostate Cancer

DTIC Science & Technology

2016-09-01

different polymer concentrations, the criti- cal micelle concentration (CMC) of Pep -b-PEG110-b-PTMC52 was determined to be approximately 8.02 × 10− 3 mg mL−1...1.8 mV (Fig. 5). Nevertheless, the control experiment without CTSK treatment afforded nearly no variation of the Fig. 3 1H NMR spectra of Pep -b-PEG110-b...PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE September 2016 2. REPORT TYPE Annual 3 . DATES COVERED 29 Aug 2015 – 28 Aug 2016 4

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089829 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089793 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089802 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089782 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089830 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089820 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

ATV Fly-Under

NASA Image and Video Library

2014-08-08

ISS040-E-089798 (8 Aug. 2014) --- The “Georges Lemaitre” Automated Transfer Vehicle (ATV-5), photographed by an Expedition 40 crew member, flies directly under the International Space Station at a distance of about 3.7 miles to test sensors and radar systems designed for future European spacecraft. After its “fly-under” of the station, the ATV will move in front of, above, and behind the outpost for the final days of its two-week rendezvous that will lead to an automated docking to the aft port of the Zvezda Service Module on Aug. 12.

Environmental Assessment: Johnson County Road F-20 Bypass, Johnson County, Iowa.

DTIC Science & Technology

1986-08-01

D-A184 328 ENVIRONMENTAL ASSESSMENT- JOHNSON COUNTY ROAD F-20 vil BYPASS JOHNSON COUNTY’ IOWA (U) ARMY ENGINEER DISTRICT ROCK ISLAND IL AUG 86...BYPASS JOHNSON COUNTY, IOWA DTIC SELECTEI AUG 24 198D AUGUST 1986 -’"Thn; c>, .. i ’, been p ore i Icr publj rJlxaje aid sale; ii ,,. I distibu on is...2004 19 EPLY TO ATTENTION OP NCRPD-E ENVIRONMENTAL ASSE SSMENT JOHNSON COUNTY ROAD F-20 BYPASS JOHNSON COUNTY, IOWA Acce3siofl For NTIS MR& QUA~rTY

Enhanced Polar System (EPS)

DTIC Science & Technology

2015-12-01

Aug 2014 Aug 2014 Feb 2015 Jul 2014 DT&E Completion for Single String May 2017 May 2017 Nov 2017 May 2017 RAA Jun 2018 Jun 2018 Jun 2019 Jun 2018 Change...as defined by Section 12.0 of the EPS CDD dated September 15, 2011 in support of IOC. RAA is the date two hosted payloads, T&C-T, CAPS, and the Gateway...system with the three NMTs are available for operational use per Section 12.3 of the EPS CDD dated September 15, 2011, in support of FOC. The RAA

Commissioning of inline ECE system within waveguide based ECRH transmission systems on ASDEX upgrade

NASA Astrophysics Data System (ADS)

Bongers, W. A.; Kasparek, W.; Doelman, N.; van den Braber, R.; van den Brand, H.; Meo, F.; de Baar, M. R.; Amerongen, F. J.; Donné, A. J. H.; Elzendoorn, B. S. Q.; Erckmann, V.; Goede, A. P. H.; Giannone, L.; Grünwald, G.; Hollman, F.; Kaas, G.; Krijger, B.; Michel, G.; Lubyako, L.; Monaco, F.; Noke, F.; Petelin, M.; Plaum, B.; Purps, F.; ten Pierik, J. G. W.; Schüller, C.; Slob, J. W.; Stober, J. K.; Schütz, H.; Wagner, D.; Westerhof, E.; Ronden, D. M. S.

2012-09-01

A CW capable inline electron cyclotron emission (ECE) separation system for feedback control, featuring oversized corrugated waveguides, is commissioned on ASDEX upgrade (AUG). The system is based on a combination of a polarization independent, non-resonant, Mach-Zehnder diplexer equipped with dielectric plate beam splitters [2, 3] employed as corrugated oversized waveguide filter, and a resonant Fast Directional Switch, FADIS [4, 5, 6, 7] as ECE/ECCD separation system. This paper presents an overview of the system, the low power characterisation tests and first high power commissioning on AUG.

Two Coronal Mass Ejections Events Close to the Total Solar Eclipse Aug. 11, 1999

NASA Astrophysics Data System (ADS)

Churyumov, K. I.; Ivanchuk, V. I.

We present some results of exploration of the solar corona on the basis of analysis of its images obtained in Romania by K.I.Churyumov and in Bulgaria by V.Mormyl' and S.Kharchuk Aug. 11 1999. Structure of the corona is characterized by the presence of numerous power and thin rays which have mainly radial orientation in regard to the Sun. The high-latitude rays of the north hemisphere (especially in the NE sector) are inclined in the direction of the N-pole. The interesting peculiarity of the solar corona Aug. 11 1999 is the existence of the sabre-like thin double ray on the NE-limb, which goes from the solar limb region at p ~ 50o. It is close to the peculiar center of ``repulsion'', which is observed for the fan of rays of the E-limb. We proposed that the similar rays and the observed center of ``repulsion'' were an indicator (postcursor) which shows that in this place of the corona the phenomena of the coronal mass ejections (CME) of the coronal plasma occurred. This views was confirmed by observations of the solar corona with the help of the Lasco C2 coronograph of SOHO Aug. 10/11 1999. In the region of the NW-quadrant and near the W-equator the enough sharp transequatorial arc by height ~ 0.7Rsolar with the center at ϕo = +10 deg is detected. It is nonfull arcs which intersects set of rays structures and near its foundation on the altitude /~ 0.3Rsolar there is a coronal condensation with characteristic sizes Δ l ~ 0.1Rsolar. We think that it is tied with development of a coronal mass ejection (CME) detected by the coronograph Lasco C2 of SOHO Aug. 11/12, 1999. On the best pictures it is seen that CME had the angle sizes ~ 90 deg and filled in nearly the all NW quadrant as a not uniform buble. On the basis of the published data we determined several

Study pre-earthquake features in the Earth atmosphere-ionosphere environment associated with 2016 Amatrice-Norcia (Central Italy) seismic sequence

NASA Astrophysics Data System (ADS)

Ouzounov, Dimitar; Pulinets, Sergey; Giuliani, Gioacchino; Hernández-Pajares, Manuel; García-Rigo, Alberto

2017-04-01

The 2016 Amatrice-Norcia (Central Italy) seismic sequence (M6.3, M6.1 and M6.5), became one of the unusual and important modern earthquake events. Recent studies indicate (including April 6th 2009 Abruzzo earthquake) an enhanced coupling between the atmospheric boundary layer and the ionosphere, which have been proposed to be related with large (>M6) earthquakes. This relationship has been studied for the 2016 Central Italy sequence using an integrated set of observations of five physical and environmental parameters. We present observational data from January to November 2016 of five physical parameters- radon, seismicity, temperature of the atmosphere boundary layer, outgoing earth infrared radiation and GPS/TEC and their temporal and spatial variations several days before the onset of the Amatrice-Norcia earthquake sequence. The Aug 24 M6.2 foreshock was situated about 70 kilometers from the 2 stations of radon near L'Aquila. These data show an increase prior to the main earthquake beginning in July-August this enhancement of radon coincides (with some delay) with an increase in the atmospheric chemical potential (Aug 11) measured near the epicentral area from satellite. And subsequently from Aug12 there was an association with the acceleration of outgoing infrared radiation observed on the top of the atmosphere from EOS satellite (Aug 16). The GPS/Total Electron Content data indicate an increase of electron concentration in ionosphere on August 22 and October 26, 1-2 days before the M6.2 foreshock and the M6.5 main shock on Oct 30, 2016. Both ground and satellite data have in common that they were evident in about the last ten days before the M6.2 foreshock of Aug 24 and continuously up to the main shock of Oct 30, although the radon variations started 2 months earlier. We examined the possible correlation between different pre-earthquake signals in the frame of a multidisciplinary investigation of Lithosphere -Atmosphere -Ionosphere coupling concept.

Modeling photoabsorption of the asFP595 chromophore.

PubMed

Bravaya, Ksenia B; Bochenkova, Anastasia V; Granovsky, Alexander A; Savitsky, Alexander P; Nemukhin, Alexander V

2008-09-18

The fluorescent protein asFP595 is a promising photoswitchable biomarker for studying processes in living cells. We present the results of a high level theoretical study of photoabsorption properties of the model asFP595 chromophore molecule in biologically relevant protonation states: anionic, zwitterionic, and neutral. Ground state equilibrium geometry parameters are optimized in the PBE0/(aug)-cc-pVDZ density functional theory approximation. An augmented version of multiconfigurational quasidegenerate perturbation theory (aug-MCQDPT2) following the state-averaged CASSCF/(aug)-cc-pVDZ calculations is used to estimate the vertical S0-S1 excitation energies for all chromophore species. An accuracy of this approach is validated by comparing the computed estimates of the S0-S1 absorption maximum of the closely related chromophore from the DsRed protein to the known experimental value in the gas phase. An influence of the CASSCF active space on the aug-MCQDPT2 excitation energies is analyzed. The zwitterionic form of the asFP595 chromophore is found to be the most sensitive to a particular choice and amount of active orbitals. This observation is explained by the charge-transfer type of the S0-S1 transition involving the entire conjugated pi-electron system for the zwitterionic protonation state. According to the calculation results, the anionic form in the trans conformation is found to possess the most red-shifted absorption band with the maximum located at 543 nm. The bands of the zwitterionic and neutral forms are considerably blue-shifted compared to those of the anionic form. These conclusions are at variance with the results obtained in the TDDFT approximation for the asFP595 chromophore. The absorption wavelengths computed in the aug-MCQDPT2/CASSCF theory are as follows: 543 (535), 470 (476), and 415 (417) nm for the anionic, zwitterionic, and neutral forms of the trans and cis (in parentheses) isomers of the asFP595 chromophore. These data can be used as a reference for further theoretical studies of the asFP595 chromophore in different media and for modeling photoabsorption properties of the asFP595 fluorescent protein.

The Rift Valley fever accessory proteins NSm and P78/NSm-GN are distinct determinants of virus propagation in vertebrate and invertebrate hosts

PubMed Central

Kreher, Felix; Tamietti, Carole; Gommet, Céline; Guillemot, Laurent; Ermonval, Myriam; Failloux, Anna-Bella; Panthier, Jean-Jacques; Bouloy, Michèle; Flamand, Marie

2014-01-01

Rift Valley fever virus (RVFV) is an enzootic virus circulating in Africa that is transmitted to its vertebrate host by a mosquito vector and causes severe clinical manifestations in humans and ruminants. RVFV has a tripartite genome of negative or ambisense polarity. The M segment contains five in-frame AUG codons that are alternatively used for the synthesis of two major structural glycoproteins, GN and GC, and at least two accessory proteins, NSm, a 14-kDa cytosolic protein, and P78/NSm-GN, a 78-kDa glycoprotein. To determine the relative contribution of P78 and NSm to RVFV infectivity, AUG codons were knocked out to generate mutant viruses expressing various sets of the M-encoded proteins. We found that, in the absence of the second AUG codon used to express NSm, a 13-kDa protein corresponding to an N-terminally truncated form of NSm, named NSm′, was synthesized from AUG 3. None of the individual accessory proteins had any significant impact on RVFV virulence in mice. However, a mutant virus lacking both NSm and NSm′ was strongly attenuated in mice and grew to reduced titers in murine macrophages, a major target cell type of RVFV. In contrast, P78 was not associated with reduced viral virulence in mice, yet it appeared as a major determinant of virus dissemination in mosquitoes. This study demonstrates how related accessory proteins differentially contribute to RVFV propagation in mammalian and arthropod hosts. PMID:26038497

Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

PubMed Central

Hinnebusch, Alan G.

2011-01-01

Summary: The correct translation of mRNA depends critically on the ability to initiate at the right AUG codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning mechanism, wherein the small (40S) ribosomal subunit attaches to the 5′ end of the mRNA and then inspects the leader base by base for an AUG in a suitable context, using complementarity with the anticodon of methionyl initiator tRNA (Met-tRNAiMet) as the key means of identifying AUG. Over the past decade, a combination of yeast genetics, biochemical analysis in reconstituted systems, and structural biology has enabled great progress in deciphering the mechanism of ribosomal scanning. A robust molecular model now exists, describing the roles of initiation factors, notably eukaryotic initiation factor 1 (eIF1) and eIF1A, in stabilizing an “open” conformation of the 40S subunit with Met-tRNAiMet bound in a low-affinity state conducive to scanning and in triggering rearrangement into a “closed” conformation incompatible with scanning, which features Met-tRNAiMet more tightly bound to the “P” site and base paired with AUG. It has also emerged that multiple DEAD-box RNA helicases participate in producing a single-stranded “landing pad” for the 40S subunit and in removing the secondary structure to enable the mRNA to traverse the 40S mRNA-binding channel in the single-stranded form for base-by-base inspection in the P site. PMID:21885680

The electron affinities of C{sub 3}O and C{sub 4}O

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rienstra-Kiracofe, J.C.; Ellison, G.B.; Hoffman, B.C.

The authors predict the adiabatic electron affinities of C{sub 3}O and C{sub 4}O based on electronic structure calculations, using a large triple-{zeta} basis set with polarization and diffuse functions (TZ2Pf+diff) with the SCF, CCSD, and CCSD(T) methods as well as with the aug-cc-pVDZ and aug-cc-pVTZ basis sets. The results imply electron affinities for C{sub 3}O and C{sub 4}O; EA(C{sub 3}O) = 0.93 eV {+-} 0.10 and EA(C{sub 4}O) = 2.99 {+-} 0.10. The EA(C{sub 3}O) is 0.41 eV lower than the experimental value of 1.34 {+-} 0.15 eV, while the EA(C{sub 4}O) is 0.94 eV higher than the experimental valuemore » of 2.05 {+-} 0.15 eV. Optimized geometries for all species at each level of theory are given, and harmonic vibrational frequencies are reported at the SCF/TZ2Pf+diff and CCSD/aug-cc-pVDZ levels.« less

Fail-safe mechanism of GCN4 translational control—uORF2 promotes reinitiation by analogous mechanism to uORF1 and thus secures its key role in GCN4 expression

PubMed Central

Gunišová, Stanislava; Valášek, Leoš Shivaya

2014-01-01

One of the extensively studied mechanisms of gene-specific translational regulation is reinitiation. It takes place on messenger RNAs (mRNAs) where main ORF is preceded by upstream ORF (uORF). Even though uORFs generally down-regulate main ORF expression, specific uORFs exist that allow high level of downstream ORF expression. The key is their ability to retain 40S subunits on mRNA upon termination of their translation to resume scanning for the next AUG. Here, we took advantage of the exemplary model system of reinitiation, the mRNA of yeast transcriptional activator GCN4 containing four short uORFs, and show that contrary to previous reports, not only the first but the first two of its uORFs allow efficient reinitiation. Strikingly, we demonstrate that they utilize a similar molecular mechanism relying on several cis-acting 5′ reinitiation-promoting elements, one of which they share, and the interaction with the a/TIF32 subunit of translation initiation factor eIF3. Since a similar mechanism operates also on YAP1 uORF, our findings strongly suggest that basic principles of reinitiation are conserved. Furthermore, presence of two consecutive reinitiation-permissive uORFs followed by two reinitiation-non-permissive uORFs suggests that tightness of GCN4 translational control is ensured by a fail-safe mechanism that effectively prevents or triggers GCN4 expression under nutrient replete or deplete conditions, respectively. PMID:24623812

Earth Observation

NASA Image and Video Library

2013-08-10

ISS036-E-030910 (10 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station photographed this nocturnal image of Florida and parts of the southeast United States on Aug. 10. Almost totally filled-in light strings along both Atlantic (right) and Gulf of Mexico coasts highlight the major populated areas, with the Miami metropolitan area at bottom right being the most conspicuous. The Keys are just out of frame in lower right. The Tampa Bay/St. Petersburg area is easily recognizable near frame center, and the jutting Cape Canaveral, which is home to NASA's Kennedy Space Center, is just below right center.

Apollo 11 crewmen released from quarantine

NASA Image and Video Library

1969-08-07

S69-41359 (10 Aug. 1969) --- Astronauts Michael Collins (left) and Edwin E. Aldrin Jr., are greeted by Dr. Robert R. Gilruth, director, Manned Spacecraft Center (MSC), and others upon their release from quarantine. The Apollo 11 crew left the Crew Reception Area (CRA) of the Lunar Receiving Laboratory (LRL) at 9 p.m., Aug. 10, 1969. While astronauts Neil A. Armstrong, commander, and Aldrin, lunar module pilot, descended in the Lunar Module (LM) "Eagle" to explore the Sea of Tranquility region of the moon, astronaut Collins, command module pilot, remained with the Command and Service Modules (CSM) "Columbia" in lunar orbit.

STS-121 Crew attends the "X Games" in Los Angeles

NASA Image and Video Library

2006-08-03

JSC2006-E-32815 (3 Aug. 2006) --- The crew of STS-121 attended opening day of the 12th "X Games" in Los Angeles Aug. 3, discussing their recent mission to the International Space Station with students and athletes. From left to right are astronauts Piers J. Sellers, Stephanie D. Wilson, Steven W. Lindsey, Michael E. Fossum, Lisa M. Nowak and Mark E. Kelly. In the background is the signature 80 foot high "Big Air Jump" skateboarding ramp - one of the event highlights. The crew's visit also included presentations at the Jet Propulsion Laboratory and the California Science Center.

Earth observation taken by the Expedition 28 crew

NASA Image and Video Library

2011-08-23

ISS028-E-030243 (23 Aug. 2011) --- A digital photo from the International Space Station from Aug. 23, 2011, allows the viewer to look toward the southwest at part of Hurricane Irene churning near the northern Bahamas, including Great Abaco Island (lower right), Andros Island under a thunderstorm (center right) and a ?fair? Cuba from left to right (upper center). The outflow and some of the banding of the northwest side of Irene are visible on the lower left. Meteorologists say Irene probably was centered over Acklins Island packing 120 mile per hour winds when the photo was taken.

The Army Meter Data Management System (MDMS): A Case Study for Army MDMS Pilot

DTIC Science & Technology

2011-05-11

Academy (West Point, NY) • Meets DoD cyber-security requirements – Received Authority to Operate from Army NETCOM effective 23 April 2010 – Received...to Operate on DoD network – Received ATO from Army NETCOM effective 23 April 2010 – Received CoN from Army NETCOM on 26 July 2010 • Over 195 meters...SCH~ From I Aug 2010001D To 8 Aug 2010 00 00 En•l’iY f*ttk COnWtnptlon J96S9U81’ WII FillCilftl .. Totol , ......... ~ Metert - Met el\\ r;’l

last ATV docking OBT

NASA Image and Video Library

2014-08-07

ISS040-E-089629 (7 Aug. 2014) --- In the International Space Station?s Zvezda Service Module, European Space Agency astronaut Alexander Gerst (foreground) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, participate in a training session in preparation for the rendezvous and docking of ESA?s fifth and final Automated Transfer Vehicle (ATV-5). Nicknamed the ?Georges Lemaitre? in honor of the Belgian physicist and astronomer who first proposed the Big Bang theory, ATV-5 will deliver more than seven tons of scientific experiments, food and other supplies when it docks to the aft end of Zvezda on Aug. 12.

last ATV docking OBT

NASA Image and Video Library

2014-08-07

ISS040-E-089627 (7 Aug. 2014) --- In the International Space Station?s Zvezda Service Module, European Space Agency astronaut Alexander Gerst (foreground) and Russian cosmonaut Alexander Skvortsov, both Expedition 40 flight engineers, participate in a training session in preparation for the rendezvous and docking of ESA?s fifth and final Automated Transfer Vehicle (ATV-5). Nicknamed the ?Georges Lemaitre? in honor of the Belgian physicist and astronomer who first proposed the Big Bang theory, ATV-5 will deliver more than seven tons of scientific experiments, food and other supplies when it docks to the aft end of Zvezda on Aug. 12.

Spirit Ascent Movie, Rover's-Eye View

NASA Technical Reports Server (NTRS)

2005-01-01

A movie assembled from frames taken by the rear hazard-identification camera on NASA's Mars Exploration Rover Spirit shows the last few days of the rover's ascent to the crest of 'Husband Hill' inside Mars' Gusev Crater. The rover was going in reverse. Rover planners often drive Spirit backwards to keep wheel lubrication well distributed. The images in this clip span a timeframe from Spirit's 573rd martian day, or sol (Aug, 13, 2005) to sol 582 (Aug. 22, 2005), the day after the rover reached the crest. During that period, Spirit drove 136 meters (446 feet),

Operation and Maintenance of the Research Platform FLIP

DTIC Science & Technology

2013-12-17

by FLIP 2006 15Aug-11 Sept PI R. Pinkel, MPL , ONR, AESOP 02 Oct-04 Nov PI J. Hildebrand, MPL ONR Marine Mammal 2007 21 Feb-16Mar T. Golfinos ONR...Dry Dock in ARCO 30 Oct-29 Nov PIJ. Hildebrand, MPL ONR/N45 Marine Mammal 2008 03-25 Sep PI K. Melville, MPL ONR RaDyo Program 13 0ct-12Nov PI J...Hildebrand, MPL ONR Marine Mammal Research 2009 6-7 May PI K. Melville, MPL ONR Sea Trials 06-14 Jul PI K. Melville, MPL ONR ONR HiRes 03-13 Aug T

Redistribution of Decompression Stop Time from Shallow to Deep Stops Increases Incidence of Decompression Sickness in Air Decompression Dives

DTIC Science & Technology

2011-07-22

year old active duty male diver surfaced from a 170/30 air dive at <corr>12:11<corr> on 24AUG06 using MK 20 FFM and following the A-2 “deep stops...effort, and this episode responded immediately to pressure. AGE is unlikely due to the experience of the diver, the MK 20 FFM characteristics, and...from a 170/30 air dive at <corr>12:11<corr> on 24AUG06 using MK 20 FFM and following the A-2 “deep stops” experimental decompression profile

Aerospace Technologies of the 21st Century: New Technologies of Experimental Research and Simulation Held in Berlin, Germany on 8-9 June 2000

DTIC Science & Technology

2000-01-01

11. Gal-Or, B., U.S. PAT. Appl .. 08/516870/1, Aug. 18, 1995 & Isr. Pat. Appl . 113636, May 7,1995 by Gal- Or, Lichtsinder and Sherbaum.. 12. Gal-Or...B., U.S. PAT. Appl . 08/516870/2, Aug. 18, 1995 & Isr. Pat. Appl . 111265, Oct. 12,94 by Gal- Or, Lichtsinder and Sherbaum. 13. Gal-Or, B., U.S. PAT... Appl . 08/554087, Nov. 6,1995. 14. Gal-Or, B., ?Proposed Flight Testing Standards for Engine Thrust Vectoring to Maximize Kill Ra- tios, Post-Stall

The PPP Simulator: User’s Manual and Report

DTIC Science & Technology

1986-11-01

simulator: Script started on Thu Aug 28 09:16:15 1986 1 ji] -> ppp -d Benchmarks/Par/ccon6.w pau load /a/hprg’fagin/ PPPl /Benchmarks/Par,’concatOP .w Capace...EOF ) putc( c, stdout ) #else if(( fp = fopen("/a/hprg/fagin/ PPPl /notes’, fir" ))!NULL) while(( c = getc(fp)) != EOF ) putc( c, stdout ) #erndif if...hprg/fagin/ PPPl /bitl.d’, fir" ) =NULL) lddsptbl( fp, bi-tbl ); while((--argc > 0) && ((*.+argv)[0]= -I for( s =argv[0]+l; *s!=’\\0’ s++ A -A Aug 18 16

VizieR Online Data Catalog: WASP-103b radial velocities and light curves (Gillon+, 2014)

NASA Astrophysics Data System (ADS)

Gillon, M.; Anderson, D. R.; Collier-Cameron, A.; Delrez, L.; Hellier, C.; Jehin, E.; Lendl, M.; Maxted, P. F. L.; Pepe, F.; Pollacco, D.; Queloz, D.; Segransan, D.; Smith, A. M. S.; Smalley, B.; Southworth, J.; Triaud, A. H. M. J.; Udry, S.; Van Grootel, V.; West, R. G.

2014-01-01

The host star WASP-103 (1SWASPJ163715.59+071100.0 = 2MASS16371556+0711000; V=12.1, K=10.8) was observed by the southern station of the WASP survey during the 2010, 2011, and 2012 observing seasons, covering the intervals 2010 May 15 to Aug. 16, 2011 Mar. 26 to Aug. 20, and 2012 Mar. 25 to Jun. 28. Files wasp.dat, trappist.dat, euler.dat contain the photometric time-series presented in the paper. File rv.dat contains the radial velocity time-series presented in the paper. (4 data files).

Impact of the 2011 FDA transvaginal mesh safety update on AUGS members' use of synthetic mesh and biologic grafts in pelvic reconstructive surgery.

PubMed

Clemons, Jeffrey L; Weinstein, Milena; Guess, Marsha K; Alperin, Marianna; Moalli, Pamela; Gregory, William Thomas; Lukacz, Emily S; Sung, Vivian W; Chen, Bertha H; Bradley, Catherine S

2013-01-01

To describe the frequency of use and recent change in use of synthetic mesh and biologic grafts in pelvic organ prolapse (POP) and stress urinary incontinence surgery by American Urogynecology Society (AUGS) members. An electronic survey of AUGS members was conducted between December 2011 and January 2012. Frequency of graft use in POP (overall and by transvaginal and transabdominal approaches) and stress urinary incontinence surgery was queried relative to the timing of the 2011 Food and Drug Administration (FDA) safety update. Rates of materials' use before and after the statement were compared using Wilcoxon signed rank test. Fifty-three percent (507/962) of AUGS members responded and were included in analysis; 79% were urogynecologists. Before the FDA warning, in POP surgery, most (90%) used synthetic mesh and fewer (34%) used biologic grafts; 99% used synthetic mesh slings. After the FDA statement, respondents reported an overall decrease in the percent of POP cases in which they used synthetic mesh (P < 0.001) but no change in biologic graft use for POP (P = 0.37) or synthetic mesh sling use (P = 0.10). Specifically, transvaginal mesh use decreased: 40% reported decreased use and 12% stopped use. However, transvaginal mesh was still used by 61% of respondents in at least some cases. No change (62%) or increased use (12%) of mesh was reported for transabdominal POP procedures. Synthetic mesh use in transvaginal POP surgery decreased after the 2011 FDA safety update, but synthetic mesh use for transabdominal POP repair and sling procedures and overall biologic graft use in POP surgery did not decrease.

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

PubMed Central

Mandal, Debabrata; Köhrer, Caroline; Su, Dan; Babu, I. Ramesh; Chan, Clement T.Y.; Liu, Yuchen; Söll, Dieter; Blum, Paul; Kuwahara, Masayasu; Dedon, Peter C.; RajBhandary, Uttam L.

2014-01-01

Most archaea and bacteria use a modified C in the anticodon wobble position of isoleucine tRNA to base pair with A but not with G of the mRNA. This allows the tRNA to read the isoleucine codon AUA without also reading the methionine codon AUG. To understand why a modified C, and not U or modified U, is used to base pair with A, we mutated the C34 in the anticodon of Haloarcula marismortui isoleucine tRNA (tRNA2Ile) to U, expressed the mutant tRNA in Haloferax volcanii, and purified and analyzed the tRNA. Ribosome binding experiments show that although the wild-type tRNA2Ile binds exclusively to the isoleucine codon AUA, the mutant tRNA binds not only to AUA but also to AUU, another isoleucine codon, and to AUG, a methionine codon. The G34 to U mutant in the anticodon of another H. marismortui isoleucine tRNA species showed similar codon binding properties. Binding of the mutant tRNA to AUG could lead to misreading of the AUG codon and insertion of isoleucine in place of methionine. This result would explain why most archaea and bacteria do not normally use U or a modified U in the anticodon wobble position of isoleucine tRNA for reading the codon AUA. Biochemical and mass spectrometric analyses of the mutant tRNAs have led to the discovery of a new modified nucleoside, 5-cyanomethyl U in the anticodon wobble position of the mutant tRNAs. 5-Cyanomethyl U is present in total tRNAs from euryarchaea but not in crenarchaea, eubacteria, or eukaryotes. PMID:24344322

Mass balance investigation of alpine glaciers through LANDSAT TM data

NASA Technical Reports Server (NTRS)

Bayr, Klaus J.

1989-01-01

An analysis of LANDSAT Thematic Mapper (TM) data of the Pasterze Glacier and the Kleines Fleisskees in the Austrian Alps was undertaken and compared with meteorological data of nearby weather stations. Alpine or valley glaciers can be used to study regional and worldwide climate changes. Alpine glaciers respond relatively fast to a warming or cooling trend in temperature through an advance or a retreat of the terminus. In addition, the mass balance of the glacier is being affected. Last year two TM scenes of the Pasterze Glacier of Aug. 1984 and Aug. 1986 were used to study the difference in reflectance. This year, in addition to the scenes from last year, one MSS scene of Aug. 1976 and a TM scene from 1988 were examined for both the Pasterze Glacier and the Kleines Fleisskees. During the overpass of the LANDSAT on 6 Aug. 1988 ground truthing on the Pasterze Glacier was undertaken. The results indicate that there was considerable more reflectance in 1976 and 1984 than in 1986 and 1988. The climatological data of the weather stations Sonnblick and Rudolfshuette were examined and compared with the results found through the LANDSAT data. There were relations between the meteorological and LANDSAT data: the average temperature over the last 100 years showed an increase of .4 C, the snowfall was declining during the same time period but the overall precipitation did not reveal any significant change over the same period. With the use of an interactive image analysis computer, the LANDSAT scenes were studied. The terminus of the Pasterze Glacier retreated 348 m and the terminus of the Kleines Fleisskees 121 m since 1965. This approach using LANDSAT MSS and TM digital data in conjunction with meteorological data can be effectively used to monitor regional and worldwide climate changes.

Does vaginal closure force differ in the supine and standing positions?

PubMed

Morgan, Daniel M; Kaur, Gurpreet; Hsu, Yvonne; Fenner, Dee E; Guire, Kenneth; Miller, Janis; Ashton-Miller, James A; Delancey, John O L

2005-05-01

This study was undertaken to quantify resting vaginal closure force (VCF(REST)), maximum vaginal closure force (VCF(MAX)), and augmentation of vaginal closure force augmentation (VCF(AUG)) when supine and standing and to determine whether the change in intra-abdominal pressure associated with change in posture accounts for differences in VCF. Thirty-nine asymptomatic, continent women were recruited to determine, when supine and standing, the vaginal closure force (eg, the force closing the vagina in the mid-sagittal plane) and bladder pressures at rest and at maximal voluntary contraction. VCF was measured with an instrumented vaginal speculum and bladder pressure was determined with a microtip catheter. VCF(REST) was the resting pelvic floor tone, and VCF(MAX) was the peak pelvic floor force during a maximal voluntary contraction. VCF(AUG) was the difference between VCF(MAX) and VCF(REST). T tests and Pearson correlation coefficients were used for analysis. VCF(REST) when supine was 3.6 +/- 0.8 N and when standing was 6.9 +/- 1.5 N--a 92% difference (P < .001). The VCF(MAX) when supine was 7.5 +/- 2.9 N and when standing was 10.1 +/- 2.4 N--a 35% difference (P < .001). Bladder pressure when supine (10.5 +/- 4.7 cm H2O) was significantly less (P < .001) than when standing (31.0 +/- 6.4 cm H2O). The differences in bladder pressure when either supine or standing did not correlate with the corresponding differences in VCF at rest or at maximal voluntary contraction. The supine VCF(AUG) of 3.9 +/- 2.7 N, was significantly greater than the standing VCF(AUG) of 3.3+/-1.9 N. With change in posture, vaginal closure force increases because of higher intra-abdominal pressure and greater resistance in the pelvic floor muscles.

Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA.

PubMed Central

Honda, M; Brown, E A; Lemon, S M

1996-01-01

The initiation of translation on the positive-sense RNA genome of hepatitis C virus (HCV) is directed by an internal ribosomal entry site (IRES) that occupies most of the 341-nt 5' nontranslated RNA (5'NTR). Previous studies indicate that this IRES differs from picornaviral IRESs in that its activity is dependent upon RNA sequence downstream of the initiator AUG. Here, we demonstrate that the initiator AUG of HCV is located within a stem-loop (stem-loop IV) involving nt -12 to +12 (with reference to the AUG). This structure is conserved among HCV strains, and is present in the 5'NTR of the phylogenetically distant GB virus B. Mutant, nearly genome-length RNAs containing nucleotide substitutions predicted to enhance the stability of stem-loop IV were generally deficient in cap-independent translation both in vitro and in vivo. Additional mutations that destabilize the stem-loop restored translation to normal. Thus, the stability of the stem-loop is strongly but inversely correlated with the efficiency of internal initiation of translation. In contrast, mutations that stabilize this stem-loop had comparatively little effect on translation of 5' truncated RNAs by scanning ribosomes, suggesting that internal initiation of translation follows binding of the 40S ribosome directly at the site of stem-loop IV. Because stem-loop IV is not required for internal entry of ribosomes but is able to regulate this process, we speculate that it may be stabilized by interactions with a viral protein, providing a mechanism for feedback regulation of translation, which may be important for viral persistence. PMID:8849773

Sediment budget analysis from Landslide debris and river channel change during the extreme event - example of Typhoon Morakot at Laonong river, Taiwan

NASA Astrophysics Data System (ADS)

Chang, Kuo-Jen; Huang, Yu-Ting; Huang, Mei-Jen; Chiang, Yi-Lin; Yeh, En-Chao; Chao, Yu-Jui

2014-05-01

Taiwan, due to the high seismicity and high annual rainfall, numerous landslides triggered every year and severe impacts affect the island. Typhoon Morakot brought extreme and long-time rainfall for Taiwan in August 2009. It further caused huge loss of life and property in central and southern Taiwan. Laonong River is the largest tributary of Gaoping River. It's length is 137 km, and the basin area is 1373 km2. More than 2000mm rainfall brought and maximum rainfall exceeded 100mm/hr in the region by Typhoon Morakot in Aug, 2009. Its heavy rains made many landslides and debris flew into the river and further brought out accumulation and erosion on river banks of different areas. It caused severe disasters within the Laonong River drainage. In the past, the study of sediment blockage of river channel usually relies on field investigation, but due to inconvenient transportation, topographical barriers, or located in remote areas, etc. the survey is hardly to be completed sometimes. In recent years, the rapid development of remote sensing technology improves image resolution and quality significantly. Remote sensing technology can provide a wide range of image data, and provide essential and precious information. Furthermore, although the amount of sediment transportation can be estimated by using data such as rainfall, river flux, and suspended loads, the situation of large debris migration cannot be studied via those data. However, landslides, debris flow and river sediment transportation model in catchment area can be evaluated easily through analyzing the digital terrain model (DTM) . The purpose of this study is to investigate the phenomenon of river migration and to evaluate the amount of migration along Laonong River by analyzing the DEM before and after the typhoon Morakot. The DEMs are built by using the aerial images taken by digital mapping camera (DMC) and by airborne digital scanner 40 (ADS 40) before and after typhoon event. The results show that lateral erosion of the Laonong River caused by the typhoon seriously, especially in Yushan National Park, and midstream region. However, lateral erosion in downstream region is not so obvious. Meanwhile the siltation depth resulted from the Typhoon Morakot is larger in upstream region than in midstream and downstream regions. The amount of landslide debris created by Typhoon Morakot was too excessive to be transported. Materials just siltated in the upstream in place, same as in the middle stream area. Because of the amount of river slope erosion and sediment collapse in the downstream region is less than in upstream and midstream region, the amount of river erosion slightly larger than the amount of river siltation. The goals of this project are trying to decipher the sliding process and morphologic changes of large landslide areas, sediment transport and budgets, and to investigate the phenomenon of river migration. The results of this study provides not only geomatics and GIS dataset of the hazards, but also for essential geomorphologic information for other study, and for hazard mitigation and planning, as well.

Some Finite Difference Solutions of the Laminar Compressible Boundary Layer Showing the Effects of Upstream Transpiration Cooling

NASA Technical Reports Server (NTRS)

Howe, John T.

1959-01-01

Three numerical solutions of the partial differential equations describing the compressible laminar boundary layer are obtained by the finite difference method described in reports by I. Flugge-Lotz, D.C. Baxter, and this author. The solutions apply to steady-state supersonic flow without pressure gradient, over a cold wall and over an adiabatic wall, both having transpiration cooling upstream, and over an adiabatic wall with upstream cooling but without upstream transpiration. It is shown that for a given upstream wall temperature, upstream transpiration cooling affords much better protection to the adiabatic solid wall than does upstream cooling without transpiration. The results of the numerical solutions are compared with those of approximate solutions. The thermal results of the finite difference solution lie between the results of Rubesin and Inouye, and those of Libby and Pallone. When the skin-friction results of one finite difference solution are used in the thermal analysis of Rubesin and Inouye, improved agreement between the thermal results of the two methods of solution is obtained.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, Michael John; McConnaughhay, Johnie Franklin

A combustor includes a tube bundle that extends radially across at least a portion of the combustor. The tube bundle includes an upstream surface axially separated from a downstream surface, and a plurality of tubes extend from the upstream surface through the downstream surface to provide fluid communication through the tube bundle. A barrier extends radially inside the tube bundle between the upstream and downstream surfaces, and a baffle extends axially inside the tube bundle between the upstream surface and the barrier.

Rivers and reciprocity: perceptions and policy on international watercourses

NASA Astrophysics Data System (ADS)

Tian, Fuqiang

2017-04-01

The paper analyses geopolitical dimensions of the 1997 United Nations Convention on the Law of the NonNavigational Uses of International Watercourses (UNWC) using quantitative data on transboundary flows and qualitative data on basin State location within a watercourse. The UNWC has had a long and difficult history. A tendency for downstream support for, and upstream ambivalence/opposition to, the UNWC is identified. It appears not widely recognized that adverse effects can be caused by any State on other States, regardless of their upstream or downstream location. Thus downstream States consider that their actions cannot harm upstream States, and upstream States consider that the UNWC provides them with greater obligations than downstream States. Clarification of the UNWC with the principle of reciprocal obligations on all States, both upstream and downstream, will remove any ambiguity, correct misperceptions, have clear policy implications for all States, promote UNWC engagement of upstream States, and contribute to long-term global water security.

Identification of the first PAR1 deletion encompassing upstream SHOX enhancers in a family with idiopathic short stature.

PubMed

Benito-Sanz, Sara; Aza-Carmona, Miriam; Rodríguez-Estevez, Amaya; Rica-Etxebarria, Ixaso; Gracia, Ricardo; Campos-Barros, Angel; Heath, Karen E

2012-01-01

Short stature homeobox-containing gene, MIM 312865 (SHOX) is located within the pseudoautosomal region 1 (PAR1) of the sex chromosomes. Mutations in SHOX or its downstream transcriptional regulatory elements represent the underlying molecular defect in ~60% of Léri-Weill dyschondrosteosis (LWD) and ~5-15% of idiopathic short stature (ISS) patients. Recently, three novel enhancer elements have been identified upstream of SHOX but to date, no PAR1 deletions upstream of SHOX have been observed that only encompass these enhancers in LWD or ISS patients. We set out to search for genetic alterations of the upstream SHOX regulatory elements in 63 LWD and 100 ISS patients with no known alteration in SHOX or the downstream enhancer regions using a specifically designed MLPA assay, which covers the PAR1 upstream of SHOX. An upstream SHOX deletion was identified in an ISS proband and her affected father. The deletion was confirmed and delimited by array-CGH, to extend ~286 kb. The deletion included two of the upstream SHOX enhancers without affecting SHOX. The 13.3-year-old proband had proportionate short stature with normal GH and IGF-I levels. In conclusion, we have identified the first PAR1 deletion encompassing only the upstream SHOX transcription regulatory elements in a family with ISS. The loss of these elements may result in SHOX haploinsufficiency because of decreased SHOX transcription. Therefore, this upstream region should be included in the routine analysis of PAR1 in patients with LWD, LMD and ISS.

Identification of the first PAR1 deletion encompassing upstream SHOX enhancers in a family with idiopathic short stature

PubMed Central

Benito-Sanz, Sara; Aza-Carmona, Miriam; Rodríguez-Estevez, Amaya; Rica-Etxebarria, Ixaso; Gracia, Ricardo; Campos-Barros, Ángel; Heath, Karen E

2012-01-01

Short stature homeobox-containing gene, MIM 312865 (SHOX) is located within the pseudoautosomal region 1 (PAR1) of the sex chromosomes. Mutations in SHOX or its downstream transcriptional regulatory elements represent the underlying molecular defect in ∼60% of Léri-Weill dyschondrosteosis (LWD) and ∼5–15% of idiopathic short stature (ISS) patients. Recently, three novel enhancer elements have been identified upstream of SHOX but to date, no PAR1 deletions upstream of SHOX have been observed that only encompass these enhancers in LWD or ISS patients. We set out to search for genetic alterations of the upstream SHOX regulatory elements in 63 LWD and 100 ISS patients with no known alteration in SHOX or the downstream enhancer regions using a specifically designed MLPA assay, which covers the PAR1 upstream of SHOX. An upstream SHOX deletion was identified in an ISS proband and her affected father. The deletion was confirmed and delimited by array-CGH, to extend ∼286 kb. The deletion included two of the upstream SHOX enhancers without affecting SHOX. The 13.3-year-old proband had proportionate short stature with normal GH and IGF-I levels. In conclusion, we have identified the first PAR1 deletion encompassing only the upstream SHOX transcription regulatory elements in a family with ISS. The loss of these elements may result in SHOX haploinsufficiency because of decreased SHOX transcription. Therefore, this upstream region should be included in the routine analysis of PAR1 in patients with LWD, LMD and ISS. PMID:22071895

Targeting Androgen Receptor-Driven Resistance to CYP17A1 Inhibitors

DTIC Science & Technology

2015-09-01

number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE September 2015 2. REPORT TYPE Final 3. DATES COVERED 21 Aug 2014 - 20 Aug...Page Cover Page…………………………………………………………. 1 Standard Form 298………………………………………………… 2 Table...frequency by NGS. Report: We obtained three BAC clones covering ~150Mb of the coding and flanking regions for AR. Two clones were from the

STS-118 Space Shuttle Crew Honored

NASA Image and Video Library

2007-09-10

A special event honoring the crew of space shuttle mission STS-118 was held at Walt Disney World. Here, visitors enjoy the NASA display at Epcot's Innoventions Center. The event also honored teacher-turned-astronaut Barbara R. Morgan, who dedicated a plaque outside the Mission: Space attraction. Other activities included meeting with the media and students and a parade down Main Street. Mission STS-118 was the 119th shuttle program flight and the 22nd flight to the International Space Station. Space shuttle Endeavour launched from NASA's Kennedy Space Center on Aug. 8 and landed Aug. 21. The mission delivered the S5 truss, continuing the assembly of the space station.

KSC-2012-4262

NASA Image and Video Library

2012-08-03

CAPE CANAVERAL, Fla. – Graduates and guests gather for the closing ceremonies for the International Space University at the Kennedy Space center Visitor Complex on Aug. 3, 2012. The International Space University is a nine-week intensive course designed for post-graduate university students and professionals during the summer. The program is hosted by a different country each year, providing a unique educational experience for participants from around the world. NASA Kennedy Space Center and the Florida Institute of Technology co-hosted this year's event which ran from June 4 to Aug. 3. There were about 125 participants representing 31 countries. For more information, visit http://www.isunet.edu Photo credit: NASA/Kim Shiflett

Astronaut Jack Lousma in Lower Body Negative Pressure Device

NASA Image and Video Library

1973-08-09

S73-34180 (7 Aug. 1973) --- A medium close-up view of astronaut Jack R. Lousma, Skylab 3 pilot, in the Lower Body Negative Pressure Device (LBNPD), as astronaut Alan L. Bean, commander, works around the leg band area. This portion of the LBNPD MO-92 experiment was televised on Aug. 7, 1973. The LBNPD experiment is to provide information concerning the time course of cardiovascular adaptation during flight, and to provide in-flight data for predicting the degree of orthostatic intolerence and impairment of physical capacity to be expected upon returning to Earth environment. The bicycle ergometer is in the background, partially visible behind Bean. Photo credit: NASA

Ein Blick ins Licht. Einblicke in die Natur des Lichts und des Sehens, in Farbe und Fotografie.

NASA Astrophysics Data System (ADS)

Falk, D. S.; Brill, D. R.; Stork, D. G.

This book is a German translation, by A. Ehlers, of the American original "Seeing the light. Optics in nature, photography, color, vision, and holography", published in 1986. Contents: 1. Die Haupteigenschaften des Lichts. 2. Grundlagen der geometrischen Optik. 3. Spiegel und Linsen. 4. Kamera und Fotografie. 5. Das menschliche Auge und sein Sehvermögen. I: Wie das Bild erzeugt wird. 6. Optische Instrumente. 7. Das menschliche Auge und sein Sehvermögen. II: Bildverarbeitung. 8. Räumliches Sehen und Tiefenwahrnehmung. 9. Farbe. 10. Farbwahrnehmung. 11. Farbfotografie. 12. Wellenoptik. 13. Streuung und Polarisation. 14. Holografie. 15. Ein Blick in die moderne Physik.

Ansbach AAF, Katterback, Germany. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1974-10-29

jAUG 100,C lQoo 99.8 98,1 90,0 8)92 66,1 47,0 23.7 7605 176 ( SEP 100.0 100 9C 100,0 9903 95.1 84q9 72,6 54 331,1 79.9 020 OCT 100O 100 ’, 100.0...10’. 20’. 30% 40% 50% 60’. 70% 80% 1 90,% HUMIDITY (OBS jAUG 00ൊ "°,o 00vo 100.0 100. 100.0 100.0 96.8 9o#3 57 9 . 93! Wo65 looov 11009 1oo LI o.1

APOLLO COMMAND MODULE (CM) - SAFE TOUCHDOWN - PACIFIC OCEAN

NASA Image and Video Library

1971-08-07

S71-41999 (7 Aug. 1971) --- The Apollo 15 Command Module (CM), with astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot, aboard, nears a safe touchdown in the mid-Pacific Ocean to conclude a highly successful lunar landing mission. Although causing no harm to the crewmen, one of the three main parachutes failed to function properly. The splashdown occurred at 3:45:53 p.m. (CDT), Aug. 7, 1971, some 330 miles north of Honolulu, Hawaii. The three astronauts were picked up by helicopter and flown to the prime recovery ship USS Okinawa, which was only 6 1/2 miles away.

RECOVERY - APOLLO 15

NASA Image and Video Library

1971-08-07

S71-43542 (7 Aug. 1971) --- The Apollo 15 Command Module (CM), with astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot, aboard safely touches down in the mid-Pacific Ocean to conclude a highly successful lunar landing mission. Although causing no harm to the crew men, one of the three main parachutes failed to function properly. The splashdown occurred at 3:45:53 p.m. (CDT), Aug. 7, 1971, some 330 miles north of Honolulu, Hawaii. The three astronauts were picked up by helicopter and flown to the prime recovery ship, USS Okinawa, which was only 6 1/2 miles away.

RECOVERY - APOLLO 15

NASA Image and Video Library

1971-08-07

S71-43543 (7 Aug. 1971) --- The Apollo 15 Command Module (CM), with astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot, aboard safely touches down in the mid-Pacific Ocean to conclude a highly successful lunar landing mission. Although causing no harm to the crew men, one of the three main parachutes failed to function properly. The splashdown occurred at 3:45:53 p.m. (CDT), Aug. 7, 1971, some 330 miles north of Honolulu, Hawaii. The three astronauts were picked up by helicopter and flown to the prime recovery ship, USS Okinawa, which was only 6 1/2 miles away.

KSC-06pd1868

NASA Image and Video Library

2006-08-11

KENNEDY SPACE CENTER, FLA. - The STEREO observatories are the focus of attention at a media viewing held at Astrotech Space Operations in Titusville, Fla., on Aug. 11. The two observatories were mated for launch but will separate into different orbits for their mission. STEREO stands for Solar Terrestrial Relations Observatory. The STEREO mission is the first to take measurements of the sun and solar wind in 3-dimension. This new view will improve our understanding of space weather and its impact on the Earth. STEREO is expected to lift off on Aug. 31, from Launch Pad 17-B on Cape Canaveral Air Force Station in Florida. Photo credit: NASA/George Shelton.

KSC-06pd1867

NASA Image and Video Library

2006-08-11

KENNEDY SPACE CENTER, FLA. - The STEREO observatories are the focus of attention at a media viewing held at Astrotech Space Operations in Titusville, Fla., on Aug. 11. The two observatories were mated for launch but will separate into different orbits for their mission. STEREO stands for Solar Terrestrial Relations Observatory. The STEREO mission is the first to take measurements of the sun and solar wind in 3-dimension. This new view will improve our understanding of space weather and its impact on the Earth. STEREO is expected to lift off on Aug. 31, from Launch Pad 17-B on Cape Canaveral Air Force Station in Florida. Photo credit: NASA/George Shelton.

KSC-06pd1864

NASA Image and Video Library

2006-08-11

KENNEDY SPACE CENTER, FLA. - The STEREO observatories are the focus of attention at a media viewing held at Astrotech Space Operations in Titusville, Fla., on Aug. 11. The two observatories were mated for launch but will separate into different orbits for their mission. STEREO stands for Solar Terrestrial Relations Observatory. The STEREO mission is the first to take measurements of the sun and solar wind in 3-dimension. This new view will improve our understanding of space weather and its impact on the Earth. STEREO is expected to lift off on Aug. 31, from Launch Pad 17-B on Cape Canaveral Air Force Station in Florida. Photo credit: NASA/George Shelton.

KSC-06pd1866

NASA Image and Video Library

2006-08-11

KENNEDY SPACE CENTER, FLA. - The STEREO observatories are the focus of attention at a media viewing held at Astrotech Space Operations in Titusville, Fla., on Aug. 11. The two observatories were mated for launch but will separate into different orbits for their mission. STEREO stands for Solar Terrestrial Relations Observatory. The STEREO mission is the first to take measurements of the sun and solar wind in 3-dimension. This new view will improve our understanding of space weather and its impact on the Earth. STEREO is expected to lift off on Aug. 31, from Launch Pad 17-B on Cape Canaveral Air Force Station in Florida. Photo credit: NASA/George Shelton.

Qualification and implementation of line ratio spectroscopy on helium as plasma edge diagnostic at ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Griener, M.; Muñoz Burgos, J. M.; Cavedon, M.; Birkenmeier, G.; Dux, R.; Kurzan, B.; Schmitz, O.; Sieglin, B.; Stroth, U.; Viezzer, E.; Wolfrum, E.; the ASDEX Upgrade Team

2018-02-01

A new thermal helium beam diagnostic has been implemented as plasma edge diagnostic at the ASDEX Upgrade (AUG) tokamak. The helium beam is built to measure the electron density n e and temperature T e simultaneously with high spatial and temporal resolution in order to investigate steady-state as well as fast transport processes in the plasma edge region. For the thermal helium beam emission line ratio spectroscopy, neutral helium is locally injected into the plasma by a piezo valve. This enabled the measurement of the line resolved emission intensities of seven He I lines for different plasma scenarios in AUG. The different line ratios can be used together with a collisional-radiative model (CRM) to reconstruct the underlying electron temperature and density. Ratios from the same spin species are used for the electron density reconstruction, whereas spin mixed ratios are sensitive to electron temperature changes. The different line ratios as well as different CRMs are tested for their suitability for diagnostic applications. Furthermore their consistency in calculating identical parameters is validated and the resulting profiles are compared to other available diagnostics at AUG.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Papajak, Ewa; Truhlar, Donald G.

We present sets of convergent, partially augmented basis set levels corresponding to subsets of the augmented “aug-cc-pV(n+d)Z” basis sets of Dunning and co-workers. We show that for many molecular properties a basis set fully augmented with diffuse functions is computationally expensive and almost always unnecessary. On the other hand, unaugmented cc-pV(n+d)Z basis sets are insufficient for many properties that require diffuse functions. Therefore, we propose using intermediate basis sets. We developed an efficient strategy for partial augmentation, and in this article, we test it and validate it. Sequentially deleting diffuse basis functions from the “aug” basis sets yields the “jul”,more » “jun”, “may”, “apr”, etc. basis sets. Tests of these basis sets for Møller-Plesset second-order perturbation theory (MP2) show the advantages of using these partially augmented basis sets and allow us to recommend which basis sets offer the best accuracy for a given number of basis functions for calculations on large systems. Similar truncations in the diffuse space can be performed for the aug-cc-pVxZ, aug-cc-pCVxZ, etc. basis sets.« less

Structure and binding energy of the H2S dimer at the CCSD(T) complete basis set limit.

PubMed

Lemke, Kono H

2017-06-21

This study presents results for the binding energy and geometry of the H 2 S dimer which have been computed using Møller-Plesset perturbation theory (MP2, MP4) and coupled cluster (CCSD, CCSD(T)) calculations with basis sets up to aug-cc-pV5Z. Estimates of D e , E ZPE , D o , and dimer geometry have been obtained at each level of theory by taking advantage of the systematic convergence behavior toward the complete basis set (CBS) limit. The CBS limit binding energy values of D e are 1.91 (MP2), 1.75 (MP4), 1.41 (CCSD), and 1.69 kcal/mol (CCSD[T]). The most accurate values for the equilibrium S-S distance r SS (without counterpoise correction) are 4.080 (MP2/aug-cc-pV5Z), 4.131 (MP4/aug-cc-pVQZ), 4.225 (CCSD/aug-cc-pVQZ), and 4.146 Å (CCSD(T)/aug-cc-pVQZ). This study also evaluates the effect of counterpoise correction on the H 2 S dimer geometry and binding energy. As regards the structure of (H 2 S) 2 , MPn, CCSD, and CCSD(T) level values of r SS , obtained by performing geometry optimizations on the counterpoise-corrected potential energy surface, converge systematically to CBS limit values of 4.099 (MP2), 4.146 (MP4), 4.233 (CCSD), and 4.167 Å (CCSD(T)). The corresponding CBS limit values of the equilibrium binding energy D e are 1.88 (MP2), 1.76 (MP4), 1.41 (CCSD), and 1.69 kcal/mol (CCSD(T)), the latter in excellent agreement with the measured binding energy value of 1.68 ± 0.02 kcal/mol reported by Ciaffoni et al. [Appl. Phys. B 92, 627 (2008)]. Combining CBS electronic binding energies D e with E ZPE predicted by CCSD(T) vibrational second-order perturbation theory calculations yields D o = 1.08 kcal/mol, which is around 0.6 kcal/mol smaller than the measured value of 1.7 ± 0.3 kcal/mol. Overall, the results presented here demonstrate that the application of high level calculations, in particular CCSD(T), in combination with augmented correlation consistent basis sets provides valuable insight into the structure and energetics of the hydrogen sulfide dimer.

Structure and binding energy of the H2S dimer at the CCSD(T) complete basis set limit

NASA Astrophysics Data System (ADS)

Lemke, Kono H.

2017-06-01

This study presents results for the binding energy and geometry of the H2S dimer which have been computed using Møller-Plesset perturbation theory (MP2, MP4) and coupled cluster (CCSD, CCSD(T)) calculations with basis sets up to aug-cc-pV5Z. Estimates of De, EZPE, Do, and dimer geometry have been obtained at each level of theory by taking advantage of the systematic convergence behavior toward the complete basis set (CBS) limit. The CBS limit binding energy values of De are 1.91 (MP2), 1.75 (MP4), 1.41 (CCSD), and 1.69 kcal/mol (CCSD[T]). The most accurate values for the equilibrium S-S distance rSS (without counterpoise correction) are 4.080 (MP2/aug-cc-pV5Z), 4.131 (MP4/aug-cc-pVQZ), 4.225 (CCSD/aug-cc-pVQZ), and 4.146 Å (CCSD(T)/aug-cc-pVQZ). This study also evaluates the effect of counterpoise correction on the H2S dimer geometry and binding energy. As regards the structure of (H2S)2, MPn, CCSD, and CCSD(T) level values of rSS, obtained by performing geometry optimizations on the counterpoise-corrected potential energy surface, converge systematically to CBS limit values of 4.099 (MP2), 4.146 (MP4), 4.233 (CCSD), and 4.167 Å (CCSD(T)). The corresponding CBS limit values of the equilibrium binding energy De are 1.88 (MP2), 1.76 (MP4), 1.41 (CCSD), and 1.69 kcal/mol (CCSD(T)), the latter in excellent agreement with the measured binding energy value of 1.68 ± 0.02 kcal/mol reported by Ciaffoni et al. [Appl. Phys. B 92, 627 (2008)]. Combining CBS electronic binding energies De with EZPE predicted by CCSD(T) vibrational second-order perturbation theory calculations yields Do = 1.08 kcal/mol, which is around 0.6 kcal/mol smaller than the measured value of 1.7 ± 0.3 kcal/mol. Overall, the results presented here demonstrate that the application of high level calculations, in particular CCSD(T), in combination with augmented correlation consistent basis sets provides valuable insight into the structure and energetics of the hydrogen sulfide dimer.

Optical power equalization for upstream traffic with injection-locked Fabry-Perot lasers in TDM-PON

NASA Astrophysics Data System (ADS)

Huang, Ting-Tsan; Sheu, Lih-Gen; Chi, Sien

2010-10-01

An optical power equalization of upstream traffic in time-division-multiplexed passive optical network (TDM-PON) based on injection-locked Fabry-Perot lasers has been experimentally investigated. The upstream transmitters with stable spectrum are achieved by using an external injection light source in the optical line terminal (OLT). The different upstream powers can be equalized by injection locking a Fabry-Perot laser diode (FP-LD) biased below threshold current in OLT. The dynamic upstream power range from - 8.5 to - 19.5 db m is reduced to a 1.6 dB maximal power variation, when the uplink signal is directly modulated at 1.25 Gb/s.

Noise generated by flow through large butterfly valves

NASA Technical Reports Server (NTRS)

Huff, Ronald G.

1987-01-01

A large butterfly valve (1.37 m diam) was acoustically tested to measure the noise generated and propagating in both the upstream and downstream directions. The experimental investigation used wall mounted pressure transducers to measure the fluctuating component of the pipe static pressure upstream and downstream of the valve. Microphones upstream of the pipe inlet and located in a plenum were used to measure the noise radiated from the valve in the upstream direction. Comparison of the wall pressure downstream of the valve to a prediction were made. Reasonable agreement was obtained with the valve operating at a choked condition. The noise upstream of the valve is 30 dB less than that measured downstream.

Energetic particle diffusion coefficients upstream of quasi-parallel interplanetary shocks

NASA Technical Reports Server (NTRS)

Tan, L. C.; Mason, G. M.; Gloeckler, G.; Ipavich, F. M.

1989-01-01

The properties of about 30 to 130-keV/e protons and alpha particles upstream of six quasi-parallel interplanetary shocks that passed by the ISEE 3 spacecraft during 1978-1979 were analyzed, and the values for the upstream energegic particle diffusion coefficient, kappa, in these six events were deduced for a number of energies and upstream positions. These observations were compared with predictions of Lee's (1983) theory of shock acceleration. It was found that the observations verified the prediction of the A/Q dependence (where A and Q are the particle atomic mass and ionization state, respectively) of kappa for alpha and proton particles upstream of the quasi-parallel shocks.

How downstream sub-basins depend on upstream inflows to avoid scarcity: typology and global analysis of transboundary rivers

NASA Astrophysics Data System (ADS)

Munia, Hafsa Ahmed; Guillaume, Joseph H. A.; Mirumachi, Naho; Wada, Yoshihide; Kummu, Matti

2018-05-01

Countries sharing river basins are often dependent upon water originating outside their boundaries; meaning that without that upstream water, water scarcity may occur with flow-on implications for water use and management. We develop a formalisation of this concept drawing on ideas about the transition between regimes from resilience literature, using water stress and water shortage as indicators of water scarcity. In our analytical framework, dependency occurs if water from upstream is needed to avoid scarcity. This can be diagnosed by comparing different types of water availability on which a sub-basin relies, in particular local runoff and upstream inflows. At the same time, possible upstream water withdrawals reduce available water downstream, influencing the latter water availability. By developing a framework of scarcity and dependency, we contribute to the understanding of transitions between system regimes. We apply our analytical framework to global transboundary river basins at the scale of sub-basin areas (SBAs). Our results show that 1175 million people live under water stress (42 % of the total transboundary population). Surprisingly, the majority (1150 million) of these currently suffer from stress only due to their own excessive water use and possible water from upstream does not have impact on the stress status - i.e. they are not yet dependent on upstream water to avoid stress - but could still impact on the intensity of the stress. At the same time, 386 million people (14 %) live in SBAs that can avoid stress owing to available water from upstream and have thus upstream dependency. In the case of water shortage, 306 million people (11 %) live in SBAs dependent on upstream water to avoid possible shortage. The identification of transitions between system regimes sheds light on how SBAs may be affected in the future, potentially contributing to further refined analysis of inter- and intrabasin hydro-political power relations and strategic planning of management practices in transboundary basins.

Performance Enhancement by Threshold Level Control of a Receiver in WDM-PON System with Manchester Coded Downstream and NRZ Upstream Re-Modulation

NASA Astrophysics Data System (ADS)

Kim, Bong Kyu; Chung, Hwan Seok; Chang, Sun Hyok; Park, Sangjo

We propose and demonstrate a scheme enhancing the performance of optical access networks with Manchester coded downstream and re-modulated NRZ coded upstream. It is achieved by threshold level control of a limiting amplifier at a receiver, and the minimum sensitivity of upstream is significantly improved for the re-modulation scheme with 5Gb/s Manchester coded downstream and 2.488Gb/s NRZ upstream data rates.

Genetic diversity among the Eurytemora affinis species complex in the Scheldt estuary and its tributaries using ISSR-PCR marker assay

NASA Astrophysics Data System (ADS)

Gasmi, S.; Ferval, M.; Pelissier, C.; D'Amico, F.; Maris, T.; Tackx, M.; Legal, L.

2014-05-01

As an estuary being restored, the Scheldt (Belgium/The Netherlands) offers an interesting setting to study the response of organisms and ecosystems to changing conditions. This study specifically deals with this with regard to the spatio-temporal distribution and possible genetic differentiation among the species complex Eurytemora affinis (copepoda, calanoida). Until the 1990s, E. affinis typically occurred downstream the Scheldt estuary (Belgium/The Netherlands). In parallel to water quality improvement, E.affinis has recently also occurred upstream the estuary and in some of the tributaries. This paper aims to assess the origin of the copepod sibling species complex E. affinis occurring upstream the Scheldt estuary through genetic characterization. Using the Inter Simple Sequence Repeat (ISSR) technique, we explored genetic pools of the E. affinis complex in three Scheldt localities (downstream, middle-estuary and upstream) and two of its tributaries. Four ISSR primers produced 75 polymorphic loci. Bayesian and hierarchical analysis revealed different but close genetic entities in both down and upstream localities. The middle-estuary individuals were genetically a composite mix of downstream and upstream populations (84% from downstream and 16% from upstream). A distinctive separation of the tributaries and the main Scheldt stream populations suggests that two fully independent genetic pools are present. It is of note that the tributaries showed a lack of genetic subdivision, that upstream and downstream E. affinis populations are closely related, and that the downstream population is most likely at the origin of the upstream one, which implies the necessity to guarantee sufficient oxygen concentration levels throughout the estuarine continuum to guarantee the presence of this species upstream. The results of the ISSR technique are discussed in comparison with genetic studies on E. affinis using COI barcoding.

Barriers impede upstream spawning migration of flathead chub

USGS Publications Warehouse

Walters, David M.; Zuellig, Robert E.; Crockett, Harry J.; Bruce, James F.; Lukacs, Paul M.; Fitzpatrick, Ryan M.

2014-01-01

Many native cyprinids are declining throughout the North American Great Plains. Some of these species require long reaches of contiguous, flowing riverine habitat for drifting eggs or larvae to develop, and their declining populations have been attributed to habitat fragmentation or barriers (e.g., dams, dewatered channels, and reservoirs) that restrict fish movement. Upstream dispersal is also needed to maintain populations of species with passively drifting eggs or larvae, and prior researchers have suggested that these fishes migrate upstream to spawn. To test this hypothesis, we conducted a mark–recapture study of Flathead Chub Platygobio gracilis within a 91-km reach of continuous riverine habitat in Fountain Creek, Colorado. We measured CPUE, spawning readiness (percent of Flathead Chub expressing milt), and fish movement relative to a channel-spanning dam. Multiple lines of evidence indicate that Flathead Chub migrate upstream to spawn during summer. The CPUE was much higher at the base of the dam than at downstream sites; the seasonal increases in CPUE at the dam closely tracked seasonal increases in spawning readiness, and marked fish moved upstream as far as 33 km during the spawning run. The upstream migration was effectively blocked by the dam. The CPUE of Flathead Chub was much lower upstream of the OHDD than at downstream sites, and <0.2% of fish marked at the dam were recaptured upstream. This study provides the first direct evidence of spawning migration for Flathead Chub and supports the general hypothesis that barriers limit adult dispersal of these and other plains fishes.

75 FR 23600 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... feet +571 upstream of the confluence with Millers Creek. Dale Hollow Lake (Wolf River) At the confluence with +663 Unincorporated Areas of the Wolf River. Clinton County. Approximately 1,800 feet +663 upstream of the confluence with Spring Creek. Lake Cumberland Just upstream of the Wolf +760 Unincorporated...

78 FR 6745 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

...,250 feet +635 upstream of Spring Mountain Lane. Cranberry Creek at Paradise At the upstream side of +715 Township of Paradise. Browns Hill Road. Approximately 200 feet +1092 upstream of Snowbird Lane..., Schoonover Municipal Building, 25 Municipal Drive, East Stroudsburg, PA 18301. Township of Paradise Maps are...

78 FR 9831 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-12

... Drive. Wake County. Approximately 850 feet +345 upstream of Keighley Forest Drive. Richland Creek Approximately 850 feet +301 Town of Wake Forest. upstream of the confluence with Richland Creek Tributary 2... Approximately 750 feet +301 Town of Wake Forest. upstream of the confluence with Richland Creek. Approximately 0...

Adenovirus Delivered Short Hairpin RNA Targeting a Conserved Site in the 5′ Non-Translated Region Inhibits All Four Serotypes of Dengue Viruses

PubMed Central

Korrapati, Anil Babu; Swaminathan, Gokul; Singh, Aarti; Khanna, Navin; Swaminathan, Sathyamangalam

2012-01-01

Background Dengue is a mosquito-borne viral disease caused by four closely related serotypes of Dengue viruses (DENVs). This disease whose symptoms range from mild fever to potentially fatal haemorrhagic fever and hypovolemic shock, threatens nearly half the global population. There is neither a preventive vaccine nor an effective antiviral therapy against dengue disease. The difference between severe and mild disease appears to be dependent on the viral load. Early diagnosis may enable timely therapeutic intervention to blunt disease severity by reducing the viral load. Harnessing the therapeutic potential of RNA interference (RNAi) to attenuate DENV replication may offer one approach to dengue therapy. Methodology/Principal Findings We screened the non-translated regions (NTRs) of the RNA genomes of representative members of the four DENV serotypes for putative siRNA targets mapping to known transcription/translation regulatory elements. We identified a target site in the 5′ NTR that maps to the 5′ upstream AUG region, a highly conserved cis-acting element essential for viral replication. We used a replication-defective human adenovirus type 5 (AdV5) vector to deliver a short-hairpin RNA (shRNA) targeting this site into cells. We show that this shRNA matures to the cognate siRNA and is able to inhibit effectively antigen secretion, viral RNA replication and infectious virus production by all four DENV serotypes. Conclusion/Significance The data demonstrate the feasibility of using AdV5-mediated delivery of shRNAs targeting conserved sites in the viral genome to achieve inhibition of all four DENV serotypes. This paves the way towards exploration of RNAi as a possible therapeutic strategy to curtail DENV infection. PMID:22848770

Earth Observations taken by the Expedition 17 Crew

NASA Image and Video Library

2008-08-19

ISS017-E-013789 (19 Aug. 2008) --- Desert erosion in Libya is featured in this image photographed by an Expedition 17 crewmember on the International Space Station. This detailed view (covering 13 kilometers) shows the classic patterns of an erosional desert landscape located 300 kilometers south of Libya's Mediterranean coast. Widespread indented patterns are low escarpments and stream terraces generated by stream erosion -- on those few occasions in any decade when enough rain falls for streams to flow. The only areas with active sediment deposition are the stream beds which appear in this image as sinuous zones with a distinct component of black minerals, resulting in a darker coloration than adjacent low escarpments. Sediment is transported into the area from a volcanic landscape immediately upstream to the west. Other stream-generated features are several relict stream banks, one of which even shows both of the original parallel banks. According to scientists, the ancient stream banks are preserved from erosion by various hardening cements (mainly calcium carbonate and gypsum) introduced by the streams when they were active, probably during wetter climates in the past two million years. Relict stream courses show prior positions of streams, and also provide Earth analogs for similar features on Mars. The lack of vegetation is the first indication of the great aridity of the region, but sand dunes also appear as sinuous lines oriented perpendicular to the dominant northeasterly wind direction (transverse dunes). Assuming the dominant wind direction remains the same, these transverse dunes are expected to move further to the southwest over time. Some of the dunes cross the river courses, showing how seldom the river flows.

Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors.

PubMed

López-Lastra, M; Gabus, C; Darlix, J L

1997-11-01

The murine leukemia virus (MLV)-related type C viruses constitute a major class of retroviruses that includes numerous endogenous and exogenous mammalian viruses and the related avian spleen necrosis virus (SNV). The MLV-related viruses possess a long and multifunctional 5' untranslated leader involved in key steps of the viral life cycle--splicing, translation, RNA dimerization, encapsidation, and reverse transcription. Recent studies have shown that the 5' leader of Friend murine leukemia virus and Moloney murine leukemia virus can direct cap independent translation of gag precursor proteins (Berlioz et al., 1995; Vagner et al., 1995b). These data, together with structural homology studies (Koning et al., 1992), prompted us to undertake a search for new internal ribosome entry segment (IRES) of retroviral origin. Here we describe an IRES element within the 5' leader of avian reticuloendotheliosis virus type A (REV-A) genomic RNA. Data show that the REV-A 5' IRES element maps downstream of the packaging/dimerization (E/DLS) sequence (Watanabe and Temin, 1982; Darlix et al., 1992) and the minimal IRES sequence appears to be within a 129 nt fragment (nucleotides 452-580) of the 5' leader, immediately upstream of the gag AUG codon. The REV-A IRES has been successfully utilized in the construction of novel high titer MLV-based retroviral vectors, containing one or more IRES elements of retroviral origin. These retroviral constructs, which represent a starting point for the design of novel vectors suitable for gene therapy, are also of interest as a model system of internal translation initiation and its possible regulation during development, cancer, or virus infection.

Translational control of small heat shock genes in mesophilic and thermophilic cyanobacteria by RNA thermometers

PubMed Central

Cimdins, Annika; Klinkert, Birgit; Aschke-Sonnenborn, Ursula; Kaiser, Friederike M; Kortmann, Jens; Narberhaus, Franz

2014-01-01

Cyanobacteria constitute a heterogeneous phylum of oxygen-producing, photosynthetic prokaryotes. They are susceptible to various stress conditions like heat, salt, or light stress, all inducing the cyanobacterial heat shock response (HSR). Cyanobacterial small heat shock proteins (sHsps) are known to preserve thylakoid membrane integrity under stress conditions, thereby protecting the photosynthesis machinery. In Synechocystis sp PCC 6803, synthesis of the sHsp Hsp17 is regulated by an RNA thermometer (RNAT) in the 5′-untranslated region (5′-UTR) of the hsp17 mRNA. RNATs are direct temperature sensors that control expression of many bacterial heat shock and virulence genes. They hinder translation at low temperatures by base pairing, thus blocking ribosome access to the mRNA.   To explore the temperature range in which RNATs act, we studied various RNAT candidates upstream of sHsp genes from mesophilic and thermophilic cyanobacteria. The mesophilic cyanobacteria Anabaena variabilis and Nostoc sp chromosomally encode two sHsps each. Reporter gene studies suggested RNAT-mediated post-transcriptional regulation of shsp expression in both organisms. Detailed structural analysis of the two A. variabilis candidates revealed two novel RNAT types. The first, avashort, regulates translation primarily by masking of the AUG translational start codon. The second, featuring an extended initial hairpin, thus named avalong, presumably makes use of complex tertiary interaction. The 5′-UTR of the small heat shock gene hspA in the thermophile Thermosynechococcus elongatus is predicted to adopt an extended secondary structure. Structure probing revealed that the ribosome binding site was blocked at temperatures below 55 °C. The results of this study demonstrate that cyanobacteria commonly use RNATs to control expression of their small heat shock genes. PMID:24755616

View of portion of "relatively fresh" crater as photographed by Apollo 15

NASA Image and Video Library

1971-07-31

AS15-82-11082 (2 Aug. 1971) --- A close-up view of a portion of a "relatively fresh" crater, looking southeast, as photographed during the third Apollo 15 lunar surface extravehicular activity (EVA), on Aug. 2, 1971, at EVA Station No. 9, near Scarp Crater. The crater pictured is unnamed. The Apennine Front is in the background, and Hadley Delta Mountain is in the right background. While astronauts David R. Scott, commander, and James B. Irwin, lunar module pilot, descended in the Lunar Module (LM) "Falcon" to explore the moon, astronaut Alfred M. Worden, command module pilot, remained with the Command and Service Modules (CSM) in lunar orbit.

Oregon Wildfire in Eclipse Zone Imaged by NASA Satellite

NASA Image and Video Library

2017-08-21

The Whitewater Fire in the Mount Jefferson Wilderness in Oregon was started by a lightning strike. As of Aug. 18, 2017, more than 117,000 acres and 30 miles (48 kilometers) of the Pacific Crest Trail are closed to the public in an area that had been expected to be popular with people there to view the August 21 solar eclipse. The smoke clouds sit over the burned area, just west-northwest of Mount Jefferson. The image was acquired Aug. 18, 2017, covers an area of 16 by 17 miles (26.1 by 27.2 kilometers), and is located at 44.7 degrees north, 121.8 degrees west. https://photojournal.jpl.nasa.gov/catalog/PIA21877

Ft. Drum, New York. Limited Surface Observations Climatic Summary (LISOCS). Parts A-F.

DTIC Science & Technology

1987-09-01

putO r. , j FEDERAL BUILDING DI 5 trf - ,:;, lIril t 1 ,d."ASHEVILLE, N.C. 28801- 2723 04 88 88 1 29 008 REVIEW AND APPROVAL STATEMENT USAFETAC/DS-87...IlTitle: (LISOCS) Ft Drum NY. 12Personal Autor(s): 1 3aType of Reprt: Da ti Summa ry l3bTime Covered: May 44-Aug 46, May 70-Aug; 74 , Sep 48-Apr 87...l4Date of Reprt. Sep 87 l5t~p__Count: 312 17C0SATI Codes: Field-04, Group-02 l8Subjet Terms: *cl~mtoog~y *weat’ 1 .r -)rerj~t’loinditions winds prec

NASA's F-15B from the Dryden Flight Research Center flew in the supersonic shockwave of a modified U.S. Navy F-5E jet in support of the Shaped Sonic Boom Demonstration (SSBD) project. On Aug. 27, 2003, the F-5 SSBD aircraft demonstrated a method to reduce

NASA Image and Video Library

2003-08-25

NASA's F-15B research testbed jet from NASA's Dryden Flight Research Center flew in the supersonic shockwave of a Northrop Grumman Corp. modified U.S. Navy F-5E jet in support of the Shaped Sonic Boom Demonstration (SSBD) project, which is part of the DARPA's Quiet Supersonic Platform (QSP) program. On Aug. 27, 2003, the F-5 SSBD aircraft demonstrated a method to reduce the intensity of sonic booms.

KSC-07pd2414

NASA Image and Video Library

2007-09-10

KENNEDY SPACE CENTER, FLA. -- A special event honoring the crew of space shuttle mission STS-118 was held at Walt Disney World. Here, visitors enjoy the NASA display at Epcot's Innoventions Center. The event also honored teacher-turned-astronaut Barbara R. Morgan, who dedicated a plaque outside the Mission: Space attraction. Other activities included meeting with the media and students and a parade down Main Street. Mission STS-118 was the 119th shuttle program flight and the 22nd flight to the International Space Station. Space shuttle Endeavour launched from NASA's Kennedy Space Center on Aug. 8 and landed Aug. 21. The mission delivered the S5 truss, continuing the assembly of the space station. Photo credit: NASA/George Shelton

SPHERES

NASA Image and Video Library

2013-08-08

ISS036-E-029522 (7 Aug. 2013) --- In the International Space Station’s Kibo laboratory, NASA astronaut Karen Nyberg, Expedition 36 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Nyberg and NASA astronaut Chris Cassidy (not pictured) put the miniature satellites through their paces for a dry run of the SPHERES Zero Robotics tournament scheduled for Aug. 13. Teams of middle school students from Florida, Georgia, Idaho and Massachusetts will gather at the Massachusetts Institute of Technology in Cambridge to see which teams’ algorithms do the best job of commanding the free-flying robots through a series of maneuvers and objectives.

SPHERES

NASA Image and Video Library

2013-08-08

ISS036-E-029521 (7 Aug. 2013) --- In the International Space Station’s Kibo laboratory, NASA astronaut Karen Nyberg, Expedition 36 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Nyberg and NASA astronaut Chris Cassidy (not pictured) put the miniature satellites through their paces for a dry run of the SPHERES Zero Robotics tournament scheduled for Aug. 13. Teams of middle school students from Florida, Georgia, Idaho and Massachusetts will gather at the Massachusetts Institute of Technology in Cambridge to see which teams’ algorithms do the best job of commanding the free-flying robots through a series of maneuvers and objectives.

SPHERES

NASA Image and Video Library

2013-08-08

ISS036-E-029545 (7 Aug. 2013) --- In the International Space Station’s Kibo laboratory, NASA astronaut Karen Nyberg, Expedition 36 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Nyberg and NASA astronaut Chris Cassidy (not pictured) put the miniature satellites through their paces for a dry run of the SPHERES Zero Robotics tournament scheduled for Aug. 13. Teams of middle school students from Florida, Georgia, Idaho and Massachusetts will gather at the Massachusetts Institute of Technology in Cambridge to see which teams’ algorithms do the best job of commanding the free-flying robots through a series of maneuvers and objectives.

SPHERES

NASA Image and Video Library

2013-08-08

ISS036-E-029539 (7 Aug. 2013) --- In the International Space Station’s Kibo laboratory, NASA astronaut Karen Nyberg, Expedition 36 flight engineer, conducts a session with a pair of bowling-ball-sized free-flying satellites known as Synchronized Position Hold, Engage, Reorient, Experimental Satellites, or SPHERES. Nyberg and NASA astronaut Chris Cassidy (not pictured) put the miniature satellites through their paces for a dry run of the SPHERES Zero Robotics tournament scheduled for Aug. 13. Teams of middle school students from Florida, Georgia, Idaho and Massachusetts will gather at the Massachusetts Institute of Technology in Cambridge to see which teams’ algorithms do the best job of commanding the free-flying robots through a series of maneuvers and objectives.

Earth Observation

NASA Image and Video Library

2013-08-23

ISS036-E-036611 (23 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station on Aug. 23 exposed this image of the Strait of Gibraltar, where Europe and Africa meet and where the Atlantic Ocean waters flow through the strait into the Mediterranean Sea. A popular photographic target of astronauts has always been the Strait of Gibraltar, easily spotted at left center in this wide photograph, shot from the International Space Station. Spain is to the north (top) and Morocco to the south. The strait is 36 miles (58 kilometers) long and slims down to 8 miles (13 kilometers) at it?s most narrow point. The British colony of Gibraltar is north of the strait.

KSC-2012-4261

NASA Image and Video Library

2012-08-03

CAPE CANAVERAL, Fla. – A string quartet from the Brevard Symphony Orchestra performed for graduates and guests at the closing ceremonies for the International Space University at the Kennedy Space center Visitor Complex on Aug. 3, 2012. The International Space University is a nine-week intensive course designed for post-graduate university students and professionals during the summer. The program is hosted by a different country each year, providing a unique educational experience for participants from around the world. NASA Kennedy Space Center and the Florida Institute of Technology co-hosted this year's event which ran from June 4 to Aug. 3. There were about 125 participants representing 31 countries. For more information, visit http://www.isunet.edu Photo credit: NASA/Kim Shiflett

KSC-2012-4266

NASA Image and Video Library

2012-08-03

CAPE CANAVERAL, Fla. –Kennedy Space Center Deputy Director Janet Petro speaks to graduates and guests who gathered for the closing ceremonies for the International Space University at the Kennedy Space center Visitor Complex on Aug. 3, 2012. The International Space University is a nine-week intensive course designed for post-graduate university students and professionals during the summer. The program is hosted by a different country each year, providing a unique educational experience for participants from around the world. NASA Kennedy Space Center and the Florida Institute of Technology co-hosted this year's event which ran from June 4 to Aug. 3. There were about 125 participants representing 31 countries. For more information, visit http://www.isunet.edu Photo credit: NASA/Kim Shiflett

KSC-2012-4267

NASA Image and Video Library

2012-08-03

CAPE CANAVERAL, Fla. –NASA Administrator Charles Bolden delivers the keynote address during closing ceremonies for the International Space University at the Kennedy Space center Visitor Complex on Aug. 3, 2012. The International Space University is a nine-week intensive course designed for post-graduate university students and professionals during the summer. The program is hosted by a different country each year, providing a unique educational experience for participants from around the world. NASA Kennedy Space Center and the Florida Institute of Technology co-hosted this year's event which ran from June 4 to Aug. 3. There were about 125 participants representing 31 countries. For more information, visit http://www.isunet.edu Photo credit: NASA/Kim Shiflett

78 FR 10072 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... feet +8 City of Jacksonville. downstream of Atlantic Boulevard. Approximately 1,500 feet +17 upstream... City of Atlantic Beach, Pablo Creek. City of Neptune Beach. Approximately 1,100 feet +7 upstream of... confluence with +41 City of Jacksonville. Mill Dam Branch at Lantana Lakes Drive. Just upstream of Forest +45...

77 FR 49373 - Final Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-16

.... Macon Bayou Just upstream of Private +108 City of Eudora. Road. Just upstream of Verser +108 Road... Areas of Road. Logan County. Just downstream of Newton +563 Road. Just upstream of West 9th +621 Street... Road. * National Geodetic Vertical Datum. + North American Vertical Datum. Depth in feet above ground...

Increased upstream ionization due to formation of a double layer.

PubMed

Thakur, S Chakraborty; Harvey, Z; Biloiu, I A; Hansen, A; Hardin, R A; Przybysz, W S; Scime, E E

2009-01-23

We report observations that confirm a theoretical prediction that formation of a current-free double layer in a plasma expanding into a chamber of larger diameter is accompanied by an increase in ionization upstream of the double layer. The theoretical model argues that the increased ionization is needed to balance the difference in diffusive losses upstream and downstream of the expansion region. In our expanding helicon source experiments, we find that the upstream plasma density increases sharply at the same antenna frequency at which the double layer appears.

Upstream energetic ions under radial IMF - A critical test of the Fermi model

NASA Technical Reports Server (NTRS)

Sarris, E. T.; Krimigis, S. M.

1988-01-01

Eight years of interplanetary magnetic field (IMF) and energetic particle observations obtained by the IMP-8 spacecraft upstream from the bow shock have been surveyed, and 63 cases when the upstream IMF remained radial for extended periods of time (greater than 1 hour) have been accumulated. Of these, two cases have been selected during which measurable fluxes of ambient solar or corotating energetic particle events were absent. These conditions provide an excellent test to the theories of the origin of upstream energetic ions. It is shown that there are extended periods with radial IMF when no upstream energetic ions were detected. It is further shown that energetic ions in the range E of between 50 keV and 1 MeV, inclusive, are not continuously present but appear in bursts of intensities varying by more than an order of magnitude under persistently radial IMF. These measurements contradict a fundamental prediction of the Fermi mechanism for the origin of the upstream energetic ions, namely that such ions should always be present on radial IMF lines. The observations are consistent with the hypothesis that energetic (greater than about 50 keV) ions leak out from, and appear in the upstream medium sporadically, following the onset of magnetic activity within the magnetosphere.

ION ACCELERATION AT THE QUASI-PARALLEL BOW SHOCK: DECODING THE SIGNATURE OF INJECTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sundberg, Torbjörn; Haynes, Christopher T.; Burgess, D.

Collisionless shocks are efficient particle accelerators. At Earth, ions with energies exceeding 100 keV are seen upstream of the bow shock when the magnetic geometry is quasi-parallel, and large-scale supernova remnant shocks can accelerate ions into cosmic-ray energies. This energization is attributed to diffusive shock acceleration; however, for this process to become active, the ions must first be sufficiently energized. How and where this initial acceleration takes place has been one of the key unresolved issues in shock acceleration theory. Using Cluster spacecraft observations, we study the signatures of ion reflection events in the turbulent transition layer upstream of the terrestrial bowmore » shock, and with the support of a hybrid simulation of the shock, we show that these reflection signatures are characteristic of the first step in the ion injection process. These reflection events develop in particular in the region where the trailing edge of large-amplitude upstream waves intercept the local shock ramp and the upstream magnetic field changes from quasi-perpendicular to quasi-parallel. The dispersed ion velocity signature observed can be attributed to a rapid succession of ion reflections at this wave boundary. After the ions’ initial interaction with the shock, they flow upstream along the quasi-parallel magnetic field. Each subsequent wavefront in the upstream region will sweep the ions back toward the shock, where they gain energy with each transition between the upstream and the shock wave frames. Within three to five gyroperiods, some ions have gained enough parallel velocity to escape upstream, thus completing the injection process.« less

Large Drought-induced Variations in Oak Leaf Volatile Organic Compound Emissions during PINOT NOIR 2012

EPA Pesticide Factsheets

Leaf level oak isoprene emissions and co2/H2O exchange in the Ozarks, USABAGeron.csv is the speciated biomass displayed in Figure 1.Biomass Dry Weights.xlsx is used to convert leaf area to dry leaf biomass and is used in Figure 2.Daly Ozarks leaf ISOP.txt and MOFLUX_Isoprene Summary_refined Tcurve data.xlsx are the leaf isoprene emission rate files shown in Figure 2.Harley Aug12_Chris.xls is the leaf isoprene emission rate file shown in Figure 3.Daly Ozarks leaf.txt is the BVOC emissions file used for Figure 7 and Table 4.Drought IS.txt is the review data given in Table 2.Fig4 Aug10 2012 Harley.txt is shown in Figure 4.Fig 5 Aug14 2012 Harley.txt is shown in Figure 5.Daly Ozarks Leaf.txt is used in Fig 7.Drought IS.txt is used in Fig 8.This dataset is associated with the following publication:Geron , C., R. Daly , P. Harley, R. Rasmussen, R. Seco, A. Guenther, T. Karl, and L. Gu. Large Drought-Induced Variations in Oak Leaf Volatile Organic Compound Emissions during PINOT NOIR 2012. CHEMOSPHERE. Elsevier Science Ltd, New York, NY, USA, 146: 8-21, (2016).

Preparation methodologies and nano/microstructural evaluation of metal/semiconductor thin films.

PubMed

Chen, Zhiwen; Jiao, Zheng; Wu, Minghong; Shek, Chan-Hung; Wu, C M Lawrence; Lai, Joseph K L

2012-01-01

Metal/semiconductor thin films are a class of unique materials that are widespread technological applications, particularly in the field of microelectronic devices. Assessment strategies of fractal and tures are of fundamental importance in the development of nano/microdevices. This review presents the preparation methodologies and nano/microstructural evaluation of metal/semiconductor thin films including Au/Ge bilayer films and Pd-Ge alloy thin films, which show in the form of fractals and nanocrystals. Firstly, the extended version of Au/Ge thin films for the fractal crystallization of amorphous Ge and the formation of nanocrystals developed with improved micro- and nanostructured features are described in Section 2. Secondly, the nano/microstructural characteristics of Pd/Ge alloy thin films during annealing have been investigated in detail and described in Section 3. Finally, we will draw the conclusions from the present work as shown in Section 4. It is expected that the preparation methodologies developed and the knowledge of nano/microstructural evolution gained in metal/semiconductor thin films, including Au/Ge bilayer films and Pd-Ge alloy thin films, will provide an important fundamental basis underpinning further interdisciplinary research in these fields such as physics, chemistry, materials science, and nanoscience and nanotechnology, leading to promising exciting opportunities for future technological applications involving these thin films.

76 FR 39063 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

...,000 None +6802 feet upstream of Rodeo Road. Arroyo De La Piedra Approximately 300 feet +7099 +7103... +7043 City of Santa Fe. upstream of the Arroyo De La Piedra confluence. Approximately 600 feet None.... Approximately 0.3 mile None +7780 upstream of La Entrada. East Arroyo De La Piedra At the Arroyo De La None...

75 FR 50955 - Proposed Flood Elevation Determinations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... the intersection of of Kennebunk, Town of Great Hill Road and Kennebunkport, Town of Sand Dollar Lane... Boston Road. Little Ossipee River Approximately 0.6 mile None +287 Town of Hollis. upstream of Sand Pond Road. Approximately 0.9 mile None +287 upstream of Sand Pond Road. Little River Just upstream of the...

The "WFD-effect" on upstream-downstream relations in international river basins - insights from the Rhine and the Elbe basins

NASA Astrophysics Data System (ADS)

Moellenkamp, S.

2007-06-01

The upstream-downstream relationship in international river basins is a traditional challenge in water management. Water use in upstream countries often has a negative impact on water use in downstream countries. This is most evident in the classical example of industrial pollution in upstream countries hindering drinking water production downstream. The European Water Framework Directive (WFD) gives new impetus to the river basin approach and to international co-operation in European catchments. It aims at transforming a mainly water quality oriented management into a more integrated approach of ecosystem management. After discussing the traditional upstream-downstream relationship, this article shows that the WFD has a balancing effect on upstream-downstream problems and that it enhances river basin solidarity in international basins. While it lifts the downstream countries to the same level as the upstream countries, it also leads to new duties for the downstream states. Following the ecosystem approach, measures taken by downstream countries become increasingly more important. For example, downstream countries need to take measures to allow for migrating fish species to reach upstream stretches of river systems. With the WFD, fish populations receive increased attention, as they are an important indicator for the ecological status. The European Commission acquires a new role of inspection and control in river basin management, which finally also leads to enhanced cooperation and solidarity among the states in a basin. In order to achieve better water quality and to mitigate upstream-downstream problems, also economic instruments can be applied and the WFD does not exclude the possibility of making use of financial compensations, if at the same time the polluter pays principle is taken into account. The results presented in this article originate from a broader study on integrated water resources management conducted at Bonn University and refer to the Rhine and Elbe basins (Moellenkamp, 2006).

Petrology of the zoned calcalkaline magma chamber of Mount Mazama, Crater Lake, Oregon

USGS Publications Warehouse

Druitt, T.H.; Bacon, C.R.

1989-01-01

Evolution of the magma chamber at Mount Mazama involved repeated recharge by two types of andesite (high-Sr and low-Sr), crystal fractionation, crystal accumulation, assimilation, and magma mixing (Bacon and Druitt 1988). This paper addresses the modal compositions, textures, mineral chemistry and magmatic temperatures of (i) products of the 6845??50 BP climactic eruption, (ii) blocks of partially fused granitoid wallrock found in the ejecta, and (iii) preclimactic rhyodacitic lavas leaked from the chamber in late Pleistocene and early Holocene time. Immediately prior to the climactic eruption the chamber contained ??? 40 km3 of rhyodacite (10 vol% plag + opx + aug + hb + mt + ilm, ???880?? C) overlying high-Sr andesite and cumulus-crystal mush (28-51 vol% plag + hb ?? opx ?? aug + mt ?? ilm, 880?? to ???950?? C), which in turn overlay low-Sr crystal mush (50-66 vol% plag + opx + aug ?? hb ?? ol + mt + ilm, 890?? to ???950??? C). Despite the well known compositional gap in the ejecta, no thermal discontinuity existed in the chamber. Pre-eruptive water contents of pore liquids in most high-Sr and low-Sr mushes were 4-6 wt%, but on average the high-Sr mushes were slightly richer in water. Although parental magmas of the crystal mushes were andesitic, xenocrysts of bytownite and Ni-rich magnesian olivine in some scoriae record the one-time injection of basalt into the chamber. Textures in ol-bearing scoriae preserve evidence for the reactions ol + liq = opx and ol + aug + liq(+ plag?) = hb, which occurred in andesitic liquids at Mount Mazama. Strontium abundances in plagioclase phenocrysts constrain the petrogenesis of preclimactic and climactic rhyodacites. Phenocryst cores derived from high-Sr and low-Sr magmas have different Sr contents which can be resolved by microprobe. Partition coefficients for plagioclase in andesitic to rhyolitic glasses range from 2 to 7, and increase as glass %SiO2 increases. Evolved Pleistocene rhyodacites (???30-25,000 BP) and rhyodacites of the Holocene Llao Rock center (7015??45 BP) contain Sr-poor plagioclase and are derivatives from low-Sr magma. Rhyodacites of the Pleistocene Sharp Peak domes, Holocene Cleetwood flow (???6850 BP), and climactic ejecta contain discrete Sr-rich and Sr-poor plagioclase phenocryst populations and are hybrids produced by mixing low-Sr rhyodacite (containing Sr-poor plag + opx + aug) with a more mafic high-Sr magma (with Sr-rich plag [ + hb?]). The data reinforce the conclusions of crystal-liquid mixing calculations (Bacon and Druitt 1988), and suggest some important refinements to the magma chamber model. ?? 1989 Springer-Verlag.

Characterization of the Truncated Androgen Receptor Generated by Calpain-Dependent Proteolysis in Prostate Cancer

DTIC Science & Technology

2009-08-31

hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell, 2007. 27(3): p. 380 -92. 26. Takayama, K...TSS_upstream * 69570641 69571326 0.02 UGT2B15 -5 TSS_upstream 71417985 71418195 0.05 UNQ689 -796 TSS_upstream 29 83631386 83632082 0.02 MASA 60948

Hydrological network and classification of lakes on the Third Pole

NASA Astrophysics Data System (ADS)

Gao, Yang; Wang, Weicai; Yao, Tandong; Lu, Ning; Lu, Anxin

2018-05-01

The intensity and form of changes in closed lakes, upstream lakes and outflow lakes on the Third Pole (TP) differ based on their drainage mode. Researchers' insufficient understanding of the hydrological networks associated with lakes hampers studies of the relationship between lakes and climate. In this study, we establish a comprehensive hydrological network for each lake (>1 km2) on the TP using 106 Landsat images, 236 Chinese topographic maps, and SRTM DEM. Three-hundred-ninety-seven closed lakes, 488 upstream lakes and 317 outflow lakes totaling 3,5498.49 km2, 7,378.82 km2, and 3,382.29 km2, respectively, were identified on the TP using 2010 data. Two-hundred-thirty-four closed lakes were found to not be linked to upstream lakes. The remaining 163 closed lakes were connected to and fed by the 488 upstream lakes. The object-oriented analyses within this study indicated that more rapid changes occurred in the surface extent of closed lakes than in upstream lakes or outflow lakes on the TP from 1970 s to 2010. Furthermore, the water volume of the examined closed lakes was almost nine times greater than that of the upstream lakes from 2003 to 2009. All the examined closed lakes exhibited an obvious water volume change compared to the corresponding upstream lakes in the same basin. Furthermore, two case studies illustrate that the annual and seasonal dynamics associated with the changes in closed lakes may reflect climate change patterns, while the upstream lake dynamics may be more controlled by the lakeshore terrain and drainage characteristics. The lake inventory and hydrological network catalogued in this study provide a basis for developing a better understanding of lake response to climate change on the TP.

Water Stress in Global Transboundary River Basins: Significance of Upstream Water Use on Downstream Stress

NASA Technical Reports Server (NTRS)

Munia, H.; Guillaume, J. H. A.; Mirumachi, N.; Porkka,M.; Wada, Yoshihide; Kummu, M.

2016-01-01

Growing population and water demand have increased pressure on water resources in various parts of the globe, including many transboundary river basins. While the impacts of upstream water use on downstream water availability have been analyzed in many of these international river basins, this has not been systematically done at the global scale using coherent and comparable datasets. In this study, we aim to assess the change in downstream water stress due to upstream water use in the world's transboundary river basins. Water stress was first calculated considering only local water use of each sub-basin based on country-basin mesh, then compared with the situation when upstream water use was subtracted from downstream water availability. Wefound that water stress was generally already high when considering only local water use, affecting 0.95-1.44 billion people or 33%-51% of the population in transboundary river basins. After accounting for upstream water use, stress level increased by at least 1 percentage-point for 30-65 sub-basins, affecting 0.29-1.13 billion people. Altogether 288 out of 298 middle-stream and downstream sub-basin areas experienced some change in stress level. Further, we assessed whether there is a link between increased water stress due to upstream water use and the number of conflictive and cooperative events in the transboundary river basins, as captured by two prominent databases. No direct relationship was found. This supports the argument that conflicts and cooperation events originate from a combination of different drivers, among which upstream-induced water stress may play a role. Our findings contribute to better understanding of upstream-downstream dynamics in water stress to help address water allocation problems.

Monolithic fuel injector and related manufacturing method

DOEpatents

Ziminsky, Willy Steve [Greenville, SC; Johnson, Thomas Edward [Greenville, SC; Lacy, Benjamin [Greenville, SC; York, William David [Greenville, SC; Stevenson, Christian Xavier [Greenville, SC

2012-05-22

A monolithic fuel injection head for a fuel nozzle includes a substantially hollow vesicle body formed with an upstream end face, a downstream end face and a peripheral wall extending therebetween, an internal baffle plate extending radially outwardly from a downstream end of the bore, terminating short of the peripheral wall, thereby defining upstream and downstream fuel plenums in the vesicle body, in fluid communication by way of a radial gap between the baffle plate and the peripheral wall. A plurality of integral pre-mix tubes extend axially through the upstream and downstream fuel plenums in the vesicle body and through the baffle plate, with at least one fuel injection hole extending between each of the pre-mix tubes and the upstream fuel plenum, thereby enabling fuel in the upstream plenum to be injected into the plurality of pre-mix tubes. The fuel injection head is formed by direct metal laser sintering.

Adaptive upstream optical power adjustment depending on required power budget in PON access

NASA Astrophysics Data System (ADS)

Yeh, C. H.; Chow, C. W.; Liu, Y. L.

2012-11-01

According to the present passive optical network (PON) standard, the fiber transmission lengths are from 500 m to 20 km between the optical line terminal (OLT) and different optical network units (ONUs). It will result in difference power losses (ΔPloss) from 4 to 5 dB. Hence, we propose to adjust adaptively the output optical power of the upstream laser diode (LD) depending on the different fiber lengths. With the different fiber transmission lengths, we can properly adjust the bias current and modulation index of upstream LD for energy-saving. We characterize and analyze experimentally the relationship of output optical power and modulation amplitude Vamp under different fiber transmissions in PON access. Moreover, due to the adaptive power control of upstream signal, the optical upstream equalization also can be retrieved with power variation of 1.1 dB in this experiment.

Gas flow meter and method for measuring gas flow rate

DOEpatents

Robertson, Eric P.

2006-08-01

A gas flow rate meter includes an upstream line and two chambers having substantially equal, fixed volumes. An adjustable valve may direct the gas flow through the upstream line to either of the two chambers. A pressure monitoring device may be configured to prompt valve adjustments, directing the gas flow to an alternate chamber each time a pre-set pressure in the upstream line is reached. A method of measuring the gas flow rate measures the time required for the pressure in the upstream line to reach the pre-set pressure. The volume of the chamber and upstream line are known and fixed, thus the time required for the increase in pressure may be used to determine the flow rate of the gas. Another method of measuring the gas flow rate uses two pressure measurements of a fixed volume, taken at different times, to determine the flow rate of the gas.

Staged electrostatic precipitator

DOEpatents

Miller, Stanley J.; Almlie, Jay C.; Zhuang, Ye

2016-03-01

A device includes a chamber having an air inlet and an air outlet. The device includes a plurality of stages including at least a first stage adjacent a second stage. The plurality of stages are disposed in the chamber and each stage has a plurality of discharge electrodes disposed in an interior region and is bounded by an upstream baffle on an end proximate the air inlet and bounded by a downstream baffle on an end proximate the air outlet. Each stage has at least one sidewall between the upstream baffle and the downstream baffle. The sidewall is configured as a collection electrode and has a plurality of apertures disposed along a length between the upstream baffle and the downstream baffle. The upstream baffle of the first stage is positioned in staggered alignment relative to the upstream baffle of the second stage and the downstream baffle of the first stage are positioned in staggered alignment relative to the downstream baffle of the second stage.

Internal baffling for fuel injector

DOEpatents

Johnson, Thomas Edward; Lacy, Benjamin; Stevenson, Christian

2014-08-05

A fuel injector includes a fuel delivery tube; a plurality of pre-mixing tubes, each pre-mixing tube comprising at least one fuel injection hole; an upstream tube support plate that supports upstream ends of the plurality of pre-mixing tubes; a downstream tube support plate that supports downstream ends of the plurality of pre-mixing tubes; an outer wall connecting the upstream tube support plate and the downstream tube support plate and defining a plenum therewith; and a baffle provided in the plenum. The baffle includes a radial portion. A fuel delivered in the upstream direction by the fuel delivery tube is directed radially outwardly in the plenum between the radial portion of the baffle and the downstream tube support plate, then in the downstream direction around an outer edge portion of the radial portion, and then radially inwardly between the radial portion and the upstream tube support plate.

Smokey the Bear Toy floating in the Node 1

NASA Image and Video Library

2012-08-03

ISS032-E-011664 (3 Aug. 2012) --- Smokey Bear floats freely in the hatchway of the International Space Station’s Destiny laboratory. On May 15, 2012, Smokey traveled aboard the Soyuz spacecraft with NASA astronaut Joe Acaba and Russian cosmonauts Gennady Padalka and Sergei Revin to the space station. As a recognized symbol for wildland fire prevention, his presence on the orbiting complex also highlights the many areas of active space station research related to Earth observations, plant growth and combustion and materials sciences, as well as existing spinoff technologies in these areas. NASA, the U.S. Forest Service (USFS) and the Texas Forest Service are teaming up to celebrate Smokey's 68th birthday Aug. 9 at NASA's Johnson Space Center in Houston.

Smokey the Bear Toy floating in the Node 1

NASA Image and Video Library

2012-08-03

ISS032-E-011666 (3 Aug. 2012) --- Smokey Bear floats freely in the hatchway of the International Space Station’s Destiny laboratory. On May 15, 2012, Smokey traveled aboard the Soyuz spacecraft with NASA astronaut Joe Acaba and Russian cosmonauts Gennady Padalka and Sergei Revin to the space station. As a recognized symbol for wildland fire prevention, his presence on the orbiting complex also highlights the many areas of active space station research related to Earth observations, plant growth and combustion and materials sciences, as well as existing spinoff technologies in these areas. NASA, the U.S. Forest Service (USFS) and the Texas Forest Service are teaming up to celebrate Smokey's 68th birthday Aug. 9 at NASA's Johnson Space Center in Houston.

Station Climatic Summaries: China, the Former USSR, and Mongolia

DTIC Science & Technology

1994-02-01

DUST (BNHD) CLDCOVER 1 5 6 6 5 5 3 3 3 1 5 5 5 5 DAYS BBD < 71 # 0 # # # # # 0 # # 0 2 JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC ANN 25 REMARKS...17 3 7 1 1? DAYS BBD < 7 1 9 0 0 0 9 0 9 0 0 0 0 # 1 JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC ANN /57 REMARKS: ’ - DATA NOT AVAILABLE # - LESS... TD •PERATURE (OF) EXTRIEMAE 1 32 38 414 62 80 92 92 88 76 60 416 34 92 MEAN DAILY MAX 1 0 6 22 37 52 68 71 61 53 33 19 6 36 MEAN 1 -5 0 15 30 41 60

Smokey the Bear Toy in the Node 1

NASA Image and Video Library

2012-08-03

ISS032-E-011662 (3 Aug. 2012) --- Smokey Bear floats freely in the Unity node of the International Space Station. On May 15, 2012, Smokey traveled aboard the Soyuz spacecraft with NASA astronaut Joe Acaba and Russian cosmonauts Gennady Padalka and Sergei Revin to the space station. As a recognized symbol for wildland fire prevention, his presence on the orbiting complex also highlights the many areas of active space station research related to Earth observations, plant growth and combustion and materials sciences, as well as existing spinoff technologies in these areas. NASA, the U.S. Forest Service (USFS) and the Texas Forest Service are teaming up to celebrate Smokey's 68th birthday Aug. 9 at NASA's Johnson Space Center in Houston.

Smokey the Bear Toy in the Node 1

NASA Image and Video Library

2012-08-03

ISS032-E-011654 (3 Aug. 2012) --- Smokey Bear floats freely near crew insignias placed in the Unity node of the International Space Station. On May 15, 2012, Smokey traveled aboard the Soyuz spacecraft with NASA astronaut Joe Acaba and Russian cosmonauts Gennady Padalka and Sergei Revin to the space station. As a recognized symbol for wildland fire prevention, his presence on the orbiting complex also highlights the many areas of active space station research related to Earth observations, plant growth and combustion and materials sciences, as well as existing spinoff technologies in these areas. NASA, the U.S. Forest Service (USFS) and the Texas Forest Service are teaming up to celebrate Smokey's 68th birthday Aug. 9 at NASA's Johnson Space Center in Houston.

Smokey the Bear Toy floating in ISS Hatchway

NASA Image and Video Library

2012-08-03

ISS032-E-011678 (3 Aug. 2012) --- Smokey Bear floats freely near a hatchway on the International Space Station. On May 15, 2012, Smokey traveled aboard the Soyuz spacecraft with NASA astronaut Joe Acaba and Russian cosmonauts Gennady Padalka and Sergei Revin to the space station. As a recognized symbol for wildland fire prevention, his presence on the orbiting complex also highlights the many areas of active space station research related to Earth observations, plant growth and combustion and materials sciences, as well as existing spinoff technologies in these areas. NASA, the U.S. Forest Service (USFS) and the Texas Forest Service are teaming up to celebrate Smokey's 68th birthday Aug. 9 at NASA's Johnson Space Center in Houston.

STS-118 Space Shuttle Crew Honored

NASA Image and Video Library

2007-09-10

Members of the space shuttle mission STS-118 crew march down Main Street at Walt Disney World in Orlando. From left are Mission Specialists Alvin Drew, Barbara R. Morgan and Dave Williams, Pilot Charlie Hobaugh, Mission Specialist Tracy Caldwell and Commander Scott Kelly. Not pictured but present is Mission Specialist Rick Mastracchio. The event also honored teacher-turned-astronaut Morgan, who dedicated a plaque outside the Mission: Space attraction. Other activities included meeting with the media and students. Mission STS-118 was the 119th shuttle program flight and the 22nd flight to the International Space Station. Space shuttle Endeavour launched from NASA's Kennedy Space Center on Aug. 8 and landed Aug. 21. The mission delivered the S5 truss, continuing the assembly of the space station.

Overnight Changes Recorded by Phoenix Conductivity Probe

NASA Technical Reports Server (NTRS)

2008-01-01

This graph presents simplified data from overnight measurements by the Thermal and Electrical Conductivity Probe on NASA's Phoenix Mars Lander from noon of the mission's 70th Martian day, or sol, to noon the following sol (Aug. 5 to Aug. 6, 2008).

The graph shows that water disappeared from the atmosphere overnight, at the same time that electrical measurements detected changes consistent with addition of water to the soil.

Water in soil appears to increase overnight, when water in the atmosphere disappears.

The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

The interaction of MnH(X 7Σ+) with He: Ab initio potential energy surface and bound states

NASA Astrophysics Data System (ADS)

Turpin, Florence; Halvick, Philippe; Stoecklin, Thierry

2010-06-01

The potential energy surface of the ground state of the He-MnH(X Σ7+) van der Waals complex is presented. Within the supermolecular approach of intermolecular energy calculations, a grid of ab initio points was computed at the multireference configuration interaction level using the aug-cc-pVQZ basis set for helium and hydrogen and the relativistic aug-cc-pVQZ-DK basis set for manganese. The potential energy surface was then fitted to a global analytical form which main features are discussed. As a first application of this potential energy surface, we present accurate calculations of bound energy levels of the H3e-MnH and H4e-MnH complexes.

The interaction of MnH(X 7Sigma+) with He: ab initio potential energy surface and bound states.

PubMed

Turpin, Florence; Halvick, Philippe; Stoecklin, Thierry

2010-06-07

The potential energy surface of the ground state of the He-MnH(X (7)Sigma(+)) van der Waals complex is presented. Within the supermolecular approach of intermolecular energy calculations, a grid of ab initio points was computed at the multireference configuration interaction level using the aug-cc-pVQZ basis set for helium and hydrogen and the relativistic aug-cc-pVQZ-DK basis set for manganese. The potential energy surface was then fitted to a global analytical form which main features are discussed. As a first application of this potential energy surface, we present accurate calculations of bound energy levels of the (3)He-MnH and (4)He-MnH complexes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Kun; Zhao Hongmei; Wang Caixia

Bromoiodomethane photodissociation in the low-lying excited states has been characterized using unrestricted Hartree-Fock, configuration-interaction-singles, and complete active space self-consistent field calculations with the SDB-aug-cc-pVTZ, aug-cc-pVTZ, and 3-21g** basis sets. According to the results of the vertical excited energies and oscillator strengths of these low-lying excited states, bond selectivity is predicted. Subsequently, the minimum energy paths of the first excited singlet state and the third excited state for the dissociation reactions were calculated using the complete active space self-consistent field method with 3-21g** basis set. Good agreement is found between the calculations and experimental data. The relationships of excitations, the electronicmore » structures at Franck-Condon points, and bond selectivity are discussed.« less

Earth Observation

NASA Image and Video Library

2013-08-28

ISS036-E-037747 (28 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station on Aug. 28 photographed this vertical image that shows much of Galveston County and a small portion of southeast Harris County, Texas. Gulf of Mexico waters take up the top half of the picture. Galveston Island runs from just left of center through center right of the image, and the Bolivar Peninsula, highly impacted by Hurricane Ike five years ago, is the land mass at left center. Galveston Bay takes up much of the lower left quadrant of the pictured area. The NASA Johnson Space Center, the normal work place for NASA astronauts Chris Cassidy and Karen Nyberg, currently onboard the orbital complex, is in the bottom portion of the frame.

Earth Observation

NASA Image and Video Library

2013-08-28

ISS036-E-037751 (28 Aug. 2013) --- One of the Expedition 36 crew members aboard the International Space Station on Aug. 28 photographed this vertical image that shows much of Galveston County and a small portion of southeast Harris County, Texas. Gulf of Mexico waters take up the top one third of the picture. Galveston Island runs from just left of top center through top right of the image, and the Bolivar Peninsula, highly impacted by Hurricane Ike five years ago, is the land mass at top left. Galveston Bay is on the left side of the lower part of the frame. The NASA Johnson Space Center, the normal work place for NASA astronauts Chris Cassidy and Karen Nyberg, currently onboard the orbital complex, is in the bottom portion of the frame.

Influence of Atmosphere Weathering on the Performance of Whetlerite

DTIC Science & Technology

1982-08-20

07801 13, NUMBER OF PAGES 47 14 . MONITORING AGONCY NAME A A’ORCSSI•I dlilerens (ram Co.|tielli.n Olfl’e) is, SECURITY CLASS, (et Mhlc rtqPet) Chemical...tion, 3 velocity, inc. ON OFF days H M/min 5011 3 May 26 May 23 1270 8.53 11 5018 2 Jun 30 Jun 28 2720 8.53 20 5026 14 Jul 22 Aug 39 4680 8.84 27 5041...20.2 20.8 20.5 18.5 5026 14 Jul - 22 Aug 26.0 27.8 27.7 27.2 5041 11 Sep - 3 Nov 26.6 27.5 26.7 26.0 5062 16 Nov - 4 Feb 78 8.6 5.1 5.1 5.3 During the

View of activity in Mission Control Center during Apollo 15 EVA

NASA Image and Video Library

1971-07-30

S71-41836 (2 Aug. 1971) --- Scientist-astronaut Joseph P. Allen, left, directs the attention of astronaut Richard F. Gordon Jr., to an occurrence out of view at right in the Mission Control Center's (MCC) Mission Operations Control Room (MOCR), while Dr. Donald K. (Deke) Slayton, on right with back to camera, views activity of Apollo 15 on a large screen at the front of the MOCR. Astronauts David R. Scott and James B. Irwin are seen on the screen performing tasks of the mission's third extravehicular activity (EVA), on Aug. 2, 1971. Dr. Slayton is director of Flight Crew Operations, NASA-MSC; Gordon is Apollo 15 backup commander; and Dr. Allen is an Apollo 15 spacecraft communicator.

Feasibility of Laser Power Transmission to a High-Altitude Unmanned Aerial Vehicle

DTIC Science & Technology

2011-01-01

DecNovSepAugJulJunMay OctAprMar Baghdad Taipei FebJan 0.8 0.5 0.4 0.3 0.2 0.1 0.9 0 0.7 0.6 Laser Power Transmission Through the Atmosphere 21 Figure 3.4...DecNovSepAugJulJunMay OctAprMar Baghdad (a) Probability of 80 percent cloud cover persisting more than 2 hours Taipei FebJan 0.25 0.20 0.15 0.10 0.05 0.40 0 0.35...than 6 hours Taipei FebJan 0.25 0.20 0.15 0.10 0.05 0.40 0 0.35 0.30 If the UAV carried sufficient batteries to endure 12 cloudy hours without laser

KSC-2012-4265

NASA Image and Video Library

2012-08-03

CAPE CANAVERAL, Fla. – Gary Martin, 2012 director of Space Studies Program for the International Space University, or ISU, introduces Kennedy Space Center Deputy Director Janet Petro during ISU closing ceremonies at the Kennedy Space center Visitor Complex on Aug. 3, 2012. The International Space University is a nine-week intensive course designed for post-graduate university students and professionals during the summer. The program is hosted by a different country each year, providing a unique educational experience for participants from around the world. NASA Kennedy Space Center and the Florida Institute of Technology co-hosted this year's event which ran from June 4 to Aug. 3. There were about 125 participants representing 31 countries. For more information, visit http://www.isunet.edu Photo credit: NASA/Kim Shiflett

KSC-2012-4263

NASA Image and Video Library

2012-08-03

CAPE CANAVERAL, Fla. – Gary Martin, 2012 director of Space Studies Program for the International Space University, or ISU, welcomes graduates and guest gather for the closing ceremonies for the ISU at the Kennedy Space center Visitor Complex on Aug. 3, 2012. The International Space University is a nine-week intensive course designed for post-graduate university students and professionals during the summer. The program is hosted by a different country each year, providing a unique educational experience for participants from around the world. NASA Kennedy Space Center and the Florida Institute of Technology co-hosted this year's event which ran from June 4 to Aug. 3. There were about 125 participants representing 31 countries. For more information, visit http://www.isunet.edu Photo credit: NASA/Kim Shiflett