Hazard Studies for Solid Propellant Rocket Motors (Etude des Risque pour les Moteurs-Fusees a Propergols Solides)

DTIC Science & Technology

1990-09-01

RESEARCH AND DEVELOPMENT (ORGANISATION DU TRAITE DE LATIANTIOUF NORD) AGARDograph No.3 16 Hazard Studies for Solid Propellant Rocket Motors (Etudes de...member nations to use their research and development capabilities for the common benefit of the NATO community; - Providing scientific and technical...advice and assistance to the Military Committee in the field of aerospace research and development (with particular regard to its military application

Magmatismes tholéiitique et alcalin des demi-grabens crétacés de Mayo Oulo Léré et de Babouri Figuil (Nord du Cameroun Sud du Tchad) en domaine d'extension continentaleTholeiitic and alkaline magmatisms of the Early-Cretaceous half-grabens of Mayo Oulo Léré and Babouri Figuil (Northern Cameroon Southern Chad) in extensional structural settings

NASA Astrophysics Data System (ADS)

Ngounouno, Ismaı̈la; Déruelle, Bernard; Guiraud, René; Vicat, Jean-Paul

2001-08-01

Two major dykes of basalts, microgabbros, olivine dolerites (continental tholeiites), and of camptonites and benmoreites (alkaline rocks) are respectively exposed in the Mayo Oulo-Léré and Babouri-Figuil Early Cretaceous half-grabens (Northern Cameroon-Southern Chad). The tholeiites were probably derived from an asthenospheric source in connection with a lithospheric thinning occurring between Santonian and Eocene times. In contrast, the alkaline rocks may be derived from a deeper metasomatized mantle source.

Do First Language Writing and Second Language Reading Equal Second Language Reading Comprehension? An Assessment Dilemma

DTIC Science & Technology

1992-01-01

protectorat sur le Maroc et la Tunisie), A l’Afrique occidentale et A I’Afrique 4quatoriale plac4es sous I’autorit4 de gouverneurs,A l’Indochine...coloniale 2 de la France. 1 En 1914, 3 1 influence frangaise 3 S’Atend A l’Afrique du Nord 4 (d~partements alg~riens, 1 protectorat sur le Maroc 1 et la

Practical Considerations of Design, Fabrication and Tests for Composite Materials,

DTIC Science & Technology

1982-09-01

ORGANIZATION ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT (ORGANISATION DU TRAITE DE L’ATLANTIQUE NORD) .1 AGARD Lecture Series No. 124...of Materials Science University of Bath Claverton Down Bath AB2 7AY UK SPEAKERS Dr A.R. Bunsell Dr J.J.Gerharz Ecole Naioiiale Sup~rieure des Fra...unhofer Institfit fuer Mines de Paris Betriebsfestigkeit (IBF) Centre des Mat~riaux Darmstadt Route Nationale 7, B.P. 87 Germany 91003 Evry Cedex France

Factors of Safety, Historical Development, State of the Art and Future Outlook

DTIC Science & Technology

1977-11-01

The 1.33 value was a common factor used for pressure vessel designs, which was a major design aspect ior many missiles. The apparent intent was to...DISTRIBUTION AND AVAIL ABWLII-Tf ON BACK COVER TL~ - 211T, AGARD-R-661 ORGANISATION DU TRAITE DE L’ATLANTIQUE NORD GROUP CONSULTATIF POURLA RECHERCHE ET LE...Structural and Materials Panel formed an ad hoc Group to condense this discussion. The three pilot papers contained in this report address thedifferent

Environmental Conditions of Surface Soils and Biomass Prevailing in the Training Area at CFB Gagetown, New Brunswick

DTIC Science & Technology

2003-09-26

sur Ia caracterisation environnementale de leurs secteurs d’entrainement majeurs afin d’ameliorer les connaissances des impacts de tous les types...et geographique. En 2001, Ia premiere phase de cette etude a consiste en la caracterisation hydrogeologique partielle dans la portion nord du...secteur d’entrainement. Cette premiere phase a implique le forage de 42 puits, afin de caracteriser la dynamique et la qualite des eaux souterraines. En

Contribution of genetic influences to animal-to-animal variation in myoglobin content and beef lean color stability.

PubMed

King, D A; Shackelford, S D; Kuehn, L A; Kemp, C M; Rodriguez, A B; Thallman, R M; Wheeler, T L

2010-03-01

Longissimus thoracis steaks from steers (n = 464) with 0 to 50% inheritance of Angus, Charolais, Gelbvieh, Hereford, Limousin, Red Angus, and Simmental were evaluated during 6 d of display to assess genetic contributions to color stability. Color space values [CIE L* (lightness), a* (redness), b* (yellowness)], chroma, color change (DeltaE), and surface metmyoglobin (K/S 572/525) were determined on d 0 and 6 of display. Myoglobin concentration was highly heritable (0.85), but ultimate pH was weakly heritable (0.06). Day 0 L* values were moderately heritable (0.24). Variation in metmyoglobin, L*, and DeltaE on d 6 was moderately explained by genetic factors (41, 40, and 29%, respectively). Change during display was moderately heritable for a* (0.31), b* (0.23), chroma (0.35), and surface metmyoglobin (0.29). At the start of display, Angus steaks had greater (P < 0.05) L* values than those from all breeds except Charolais. On d 6, Angus steaks had greater (P < 0.05) L* (50.0) values than Gelbvieh, Hereford, and Simmental steaks (46.1, 44.0, and 44.5, respectively). Day 0 values for a*, b*, chroma, and DeltaE were not affected by breed (P > 0.05). On d 6, a* values were greater (P < 0.05) for Charolais and Limousin steaks (31.1 and 30.5) than Angus, Hereford, and Red Angus steaks (27.4, 27.7, and 26.3, respectively). Thus, a* changed less (P < 0.05) in Charolais and Limousin steaks (1.8 and 2.6, respectively) vs. steaks from other breeds. Day 6 b* values were greater (P < 0.05) in Charolais (24.5) and Limousin steaks (24.0) vs. Gelbvieh (22.2), Hereford (21.9), and Red Angus steaks (21.4). Thus, b* values changed less (P < 0.05) in Charolais and Limousin steaks (1.5 and 1.7, respectively) than in Angus, Gelbvieh, Hereford, and Red Angus steaks (4.3, 3.8, 4.4, and 5.1, respectively). After 6 d of display, Charolais and Limousin steaks had greater chroma (P < 0.05; 39.5 and 38.8, respectively) compared with Angus, Hereford, and Red Angus steaks (35.4, 35.3, and 33.9, respectively). Less (P < 0.05) change in chroma occurred for Charolais and Limousin (2.1 and 2.8, respectively) than in Angus, Gelbvieh, Hereford, and Red Angus steaks (7.1, 6.6, 7.4, and 9.0, respectively). Myoglobin concentration was less for Charolais and Limousin (P < 0.05; 2.77 and 2.72, respectively) compared with Gelbvieh, Red Angus, and Simmental steaks (3.62, 3.43, and 3.71, respectively). Breeds did not differ in pH (P > 0.05). These data suggest Charolais- and Limousin-carcasses produced steaks with greater lean color stability than Angus, Hereford, and Red Angus carcasses. Furthermore, these findings suggest that genetics contribute substantially to animal-to-animal variation in lean color, particularly in maintaining color.

Utilisation d'images aeroportees a tres haute resolution spatiale pour l'estimation de la vigueur des peuplements forestiers du nord-ouest du Nouveau-Brunswick

NASA Astrophysics Data System (ADS)

Louis, Ognel Pierre

Le but de cette etude est de developper un outil permettant d'estimer le niveau de risque de perte de vigueur des peuplements forestiers de la region de Gounamitz au nord-ouest du Nouveau-Brunswick via des donnees d'inventaires forestiers et des donnees de teledetection. Pour ce faire, un marteloscope de 100m x 100m et 20 parcelles d'echantillonnages ont ete delimites. A l'interieur de ces derniers, le niveau de risque de perte de vigueur des arbres ayant un DHP superieur ou egal a 9 cm a ete determine. Afin de caracteriser le risque de perte de vigueur des arbres, leurs positions spatiales ont ete repertoriees a partir d'un GPS en tenant compte des defauts au niveau des tiges. Pour mener a bien ce travail, les indices de vegetation et de textures et les bandes spectrales de l'image aeroportee ont ete extraits et consideres comme variables independantes. Le niveau de risque de perte de vigueur obtenu par espece d'arbre a travers les inventaires forestiers a ete considere comme variable dependante. En vue d'obtenir la superficie des peuplements forestiers de la region d'etude, une classification dirigee des images a partir de l'algorithme maximum de vraisemblance a ete effectuee. Le niveau de risque de perte de vigueur par type d'arbre a ensuite ete estime a l'aide des reseaux de neurones en utilisant un reseau dit perceptron multicouches. Il s'agit d'un modele de reseau de neurones compose de : 11 neurones sur la couche d'entree, correspondant aux variables independantes, 35 neurones sur la couche cachee et 4 neurones sur la couche de sortie. La prediction a partir des reseaux de neurones produit une matrice de confusion qui permet d'obtenir des mesures quantitatives d'estimation, notamment un pourcentage de classification globale de 91,7% pour la prediction du risque de perte de vigueur du peuplement de resineux et de 89,7% pour celui du peuplement de feuillus. L'evaluation de la performance des reseaux de neurones fournit une valeur de MSE globale de 0,04, et une RMSE (Mean Square Error) globale de 0,20 pour le peuplement de feuillus. Quant au peuplement de resineux, une valeur de MSE (Mean Square Error) globale de 0,05 et une valeur de RMSE globale de 0,22 ont ete obtenues. Pour la validation des resultats, le niveau de risque de perte de vigueur predit a ete compare avec le risque de perte de vigueur de reference. Les resultats obtenus donnent un coefficient de determination de 0,98 pour le peuplement de feuillus et 0,93 pour le peuplement de resineux.

Alternative Fuels Data Center: Empire Coachworks Converts Limousines to

Science.gov Websites

Natural GasA> Empire Coachworks Converts Limousines to Natural Gas to someone by E-mail Share uses compressed natural gas in ultra-lux vehicles and trams. For information about this project Cities TV and FuelEconomy.gov. Provided by Maryland Public Television Related Videos Photo of a car

Origine du soufre associé aux minéralisations Pb-Zn de type Mississippi Valley de la chaîne des Beni Snassen orientaux (Maroc nord-oriental)

NASA Astrophysics Data System (ADS)

Bouabdellah, Mohammed; Boudchiche, Lahbib; Ouahhabi, Benali; Naciri, Tayeb

2008-12-01

Sulfur isotope data measured on samples of galena from the main Mississippi Valley-type prospects of the eastern Beni Snassen belt preclude an igneous source for sulfur, pointing instead to a sedimentary source. Negative δ 34S values are interpreted to being derived from bacteriogenic reduction of Jurassic seawater sulphate. Positive δ 34S values are considered to be hydrothermal sulfide transported with metal-bearing fluid. Mixing of these two fluids resulted in the deposition of the Pb ore.

Apport de la gravimétrie à l'étude de la structure du bassin des Triffa (Maroc nord-oriental) : implications hydrogéologiques

NASA Astrophysics Data System (ADS)

Khattach, Driss; Keating, Pierre; Mili, El Mostafa; Chennouf, Touria; Andrieux, Pierre; Milhi, Abdellah

2004-12-01

Various techniques (horizontal and vertical derivatives, upward continuation, Euler deconvolution) have been applied to the gravity data from the Triffa's plain and the north flank of the Beni-Snassen massif to delineate various major geological structures such as faults and basins. These results allow the production of a structural map showing the fault systems for the survey area. This map forms the basis for planning future hydrogeological research in this region. To cite this article: D. Khattach et al., C. R. Geoscience 336 (2004).

Communique: Special Issue on the International Network for Cooperation in Northern Science Created at a Meeting held in Edmonton, Alberta (October 12-15, 1982). Summary of Discussions and Agreements Reached = Numero special sur le Reseau Scientifique Internationale pour le Nord cree a la reunion tenue a Edmonton, Alberta (du 12 au 15 octobre 1982). Resume des discussions et accords conclus.

ERIC Educational Resources Information Center

Communique, 1983

1983-01-01

Delegations from Canada, Finland, Greenland, Norway, Sweden, and the United States agreed to the establishment of a network for cooperation among individuals engaged in problems peculiar to the circumpolar North. The Northern Science Network, established within the Unesco Man and the Biosphere Program, consists of three themes: studies on the…

Physico-Chemical Characteristics of Uraniferous Supergene Minerals; CARACTERISTIQUES PHYSICO-CHIMIQUES DES MINERAUX URANIFERES SUPERGENES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Semat, M.A.

1960-01-01

Transport and deposit conditions of uraniferous minerals are breifly described. The synthesis of crystallograpic, physical, optical, and thermal properties permits defining the main characteristics of this mineralogical group. Tables to facilicate identification of the supergene uranium minerals are given on investigation by anion and cation; system, cleavages, cell parameters, interplanar spacings, refractive indices, optical barings; classification by decreasing values of the most intense line of the powder diagram; diagram for the three higher interplanar spacings; and diagram of the refractive indices. (auth)

Luminescence dating of Holocene dune complexes along the shore of northern France (Picardy)

NASA Astrophysics Data System (ADS)

Lauer, Tobias; Frechen, Manfred; Meurisse-Fort, Murielle; Gosselin, Guillaume; van Vliet-Lanoë, Brigitte

2010-05-01

The Holocene dune and peat complexes along the shore of northern France (Picardy) had already been studied in detail by Meurisse et al. (2005) and Meurisse-Fort (2009). Information about the palaeodevelopment of those dune fields is hence given due to existing 14C data as well as by sedimentological and morphological analyses. Due to the results from radiocarbon dating, different types of aeolian bodies could be correlated along the Picardy coastline and a regional stratigraphic sequence could be established (Meurisse-Fort, 2009). The aim of the ongoing study is to get a higher chronological resolution for the different phases of dune activity in Picardy by luminescence dating what is a powerful tool to determine the time of last sunlight exposure of grains before burial (this information yields important information about dune movement). Samples for OSL dating were taken from dune bodies located in Tardinghen, Hardelot, Saint-Frieux and Saint-Gabriel. For dating, a single aliquot regenerative dose (SAR) protocol (Murray & Wintle 2003) is applied to coarse grained quartz. First tests concerning the signal intensity, the purity of the quartz OSL signal and the bleaching properties showed that quartz OSL dating works well for the dunes of the northern France coastline. The new luminescence ages will help to better unravel the phases of sand dune activity and stabilisation mainly controlled by climate changes and human impact. References: Meurisse, M., Van Vliet-Lanoë, B., Talon, B. & Recourt, P. (2005): Complexes dunaires et tourbeux holocènes du littoral du Nord de la France. - Geoscience, 337 : 675-684. Meurisse-Fort, M. (2009): Enregistrement haute résolution des massifs dunaires ; Manche, mer du Nord et Atlantique - Le rôle des tempêtes. Thèse de Doctorat soutenue en juin 2007, Université de Lille1. Coll. Recherches - Sciences (Sciences de la Terre). EPU-Publibook (ed.), Paris, 310 pp. Murray, A.S. & Wintle, A.G. (2003): The single aliquot regenerative dose protocol: potential for improvements in reliability. - Radiat. Meas., 37: 377-381.

Une méthode de quantification de la dégradation d'un escarpement de faille au cours des cycles climatiques du Quaternaire : la faille de Jobourg (Nord Cotentin, France)Quantification of a fault-scarp degradation through Quaternary: the Jobourg fault (North Cotentin, France)

NASA Astrophysics Data System (ADS)

Font, Marianne; Lagarde, Jean-Louis; Amorese, Daniel; Coutard, Jean-Pierre; Ozouf, Jean-Claude

The degradation of the Jobourg fault-scarp occurred by cryoclastic processes in a periglacial environment during a part of Quaternary time. An attempt of quantification indicates a bulk scarp erosion of about 39 m 3 m -2, while the head accumulated at the bottom of the fault scarp only represents 4.6 m 3 m -2. To cite this article: M. Font et al., C. R. Geoscience 334 (2002) 171-178.

Modeling the Lowest 1 Km of the Atmosphere,

DTIC Science & Technology

1981-11-01

DU TRAITE DE L’ATLANTIQUE NORD) AGARDograph No.267 MODELING THE LOWEST 1 KM OF THE ATMOSPHERE by W.S.Lewelien Aeronautical Research Associates of... elS Energy: + Uj + (k "x1)ax3 a axj k Xj Species: ka C + + Qc (2.1.9) - Uj *xj ~ axj aj aj 4 The dependent variables in Eqs. (2.1.6 - 2.1.9) have been...0.75 uiu (3.4.10) azdz K 0~ az 8z / do-a 0.3 a 1- 2\\ 0.5 __"(34.10 - - 2uju -- 0.3 + - ~~az 6 + - Aula - - 0.45 (3.4.11) The only difficulty lies with

Effect of thermal stress on physiological parameters, feed intake and plasma thyroid hormones concentration in Alentejana, Mertolenga, Frisian and Limousine cattle breeds

NASA Astrophysics Data System (ADS)

Pereira, Alfredo M. F.; Baccari, Flávio; Titto, Evaldo A. L.; Almeida, J. A. Afonso

2008-01-01

The aim of the present study was to assess the heat tolerance of animals of two Portuguese (Alentejana and Mertolenga) and two exotic (Frisian and Limousine) cattle breeds, through the monitoring of physiological acclimatization reactions in different thermal situations characterized by alternate periods of thermoneutrality and heat stress simulated in climatic chambers. In the experiment, six heifers of the Alentejana, Frisian and Mertolenga breeds and four heifers of the Limousine breed were used. The increase in chamber temperatures had different consequences on the animals of each breed. When submitted to heat stress, the Frisian animals developed high thermal polypnea (more than 105 breath movements per minute), which did not prevent an increase in the rectal temperature (from 38.7°C to 40.0°C). However, only a slight depression in food intake and in blood thyroid hormone concentrations was observed under thermal stressful conditions. Under the thermal stressful conditions, Limousine animals decreased food intake by 11.4% and blood triiodothyronine (T3) hormone concentration decreased to 76% of the level observed in thermoneutral conditions. Alentejana animals had similar reactions. The Mertolenga cattle exhibited the highest capacity for maintaining homeothermy: under heat stressful conditions, the mean thermal polypnea increased twofold, but mean rectal temperature did not increase. Mean food intake decreased by only 2% and mean T3 blood concentration was lowered to 85,6% of the concentration observed under thermoneutral conditions. These results lead to the conclusion that the Frisian animals had more difficulty in tolerating high temperatures, the Limousine and Alentejana ones had an intermediate difficulty, and the Mertolenga animals were by far the most heat tolerant.

Developpement D'un Modele Climatique Regional: Fizr Simulation des Conditions de Janvier de la Cote Ouest Nord Americaine

NASA Astrophysics Data System (ADS)

Goyette, Stephane

1995-11-01

Le sujet de cette these concerne la modelisation numerique du climat regional. L'objectif principal de l'exercice est de developper un modele climatique regional ayant les capacites de simuler des phenomenes de meso-echelle spatiale. Notre domaine d'etude se situe sur la Cote Ouest nord americaine. Ce dernier a retenu notre attention a cause de la complexite du relief et de son controle sur le climat. Les raisons qui motivent cette etude sont multiples: d'une part, nous ne pouvons pas augmenter, en pratique, la faible resolution spatiale des modeles de la circulation generale de l'atmosphere (MCG) sans augmenter a outrance les couts d'integration et, d'autre part, la gestion de l'environnement exige de plus en plus de donnees climatiques regionales determinees avec une meilleure resolution spatiale. Jusqu'alors, les MCG constituaient les modeles les plus estimes pour leurs aptitudes a simuler le climat ainsi que les changements climatiques mondiaux. Toutefois, les phenomenes climatiques de fine echelle echappent encore aux MCG a cause de leur faible resolution spatiale. De plus, les repercussions socio-economiques des modifications possibles des climats sont etroitement liees a des phenomenes imperceptibles par les MCG actuels. Afin de circonvenir certains problemes inherents a la resolution, une approche pratique vise a prendre un domaine spatial limite d'un MCG et a y imbriquer un autre modele numerique possedant, lui, un maillage de haute resolution spatiale. Ce processus d'imbrication implique alors une nouvelle simulation numerique. Cette "retro-simulation" est guidee dans le domaine restreint a partir de pieces d'informations fournies par le MCG et forcee par des mecanismes pris en charge uniquement par le modele imbrique. Ainsi, afin de raffiner la precision spatiale des previsions climatiques de grande echelle, nous developpons ici un modele numerique appele FIZR, permettant d'obtenir de l'information climatique regionale valide a la fine echelle spatiale. Cette nouvelle gamme de modeles-interpolateurs imbriques qualifies d'"intelligents" fait partie de la famille des modeles dits "pilotes". L'hypothese directrice de notre etude est fondee sur la supposition que le climat de fine echelle est souvent gouverne par des forcages provenant de la surface plutot que par des transports atmospheriques de grande echelle spatiale. La technique que nous proposons vise donc a guider FIZR par la Dynamique echantillonnee d'un MCG et de la forcer par la Physique du MCG ainsi que par un forcage orographique de meso-echelle, en chacun des noeuds de la grille fine de calculs. Afin de valider la robustesse et la justesse de notre modele climatique regional, nous avons choisi la region de la Cote Ouest du continent nord americain. Elle est notamment caracterisee par une distribution geographique des precipitations et des temperatures fortement influencee par le relief sous-jacent. Les resultats d'une simulation d'un mois de janvier avec FIZR demontrent que nous pouvons simuler des champs de precipitations et de temperatures au niveau de l'abri beaucoup plus pres des observations climatiques comparativement a ceux simules a partir d'un MCG. Ces performances sont manifestement attribuees au forcage orographique de meso-echelle de meme qu'aux caracteristiques de surface determinees a fine echelle. Un modele similaire a FIZR peut, en principe, etre implante sur l'importe quel MCG, donc, tout organisme de recherche implique en modelisation numerique mondiale de grande echelle pourra se doter d'un el outil de regionalisation.

Growth, carcass and meat quality traits in beef from Angus, Hereford and cross-breed grazing steers, and their association with SNPs in genes related to fat deposition metabolism.

PubMed

Papaleo Mazzucco, J; Goszczynski, D E; Ripoli, M V; Melucci, L M; Pardo, A M; Colatto, E; Rogberg-Muñoz, A; Mezzadra, C A; Depetris, G J; Giovambattista, G; Villarreal, E L

2016-04-01

Grazing steers from Angus and Hereford breeds, their cross-breeds and a three-way cross-breed (Limousin × Angus-Hereford) were measured for growth, carcass and meat quality traits. Breed effects were studied, and the association of SNPs with fat deposition and fatty acid (FA) composition (leptin, melanocortin-4 receptor, stearoyl-CoA desaturase, FA synthase and thyroglobulin) was tested. Limousin cross-breed showed the greatest final body weight, ultrasound rib eye area, dressing percentage, carcass and leg length, and the lowest backfat thickness and intramuscular fat content. Genetic groups had similar pH, shear force, cooking loss, L* and b* and n-6:n-3 ratio. Meat from 1/2-Angus presented greater a* than Limousin cross-breed. Whereas Angus had the highest total SFA content, Hereford had the lowest total SFA and the highest total MUFA. Limousin cross-breed had greater content of several individual PUFAs, total PUFA, n-6 and n-3 FA than Angus and 1/2-Angus. Leptin and FA synthase were associated with some FAs, supporting their influence over fat metabolism for grazing animals. Copyright © 2015 Elsevier Ltd. All rights reserved.

Cancer du sein au Cameroun, profil histo-épidémiologique: à propos de 3044 cas

PubMed Central

Engbang, Jean Paul Ndamba; Essome, Henri; Koh, Valère Mve; Simo, Godefroy; Essam, Jean Daniel Sime; Mouelle, Albert Sone; Essame, Jean Louis Oyono

2015-01-01

Décrire les caractéristiques épidémiologiques et histo-pathologiques des tumeurs malignes du sein au Cameroun. Il s'agissait d'une étude rétrospective descriptive portant sur les tumeurs malignes du sein, colligées, dans les registres des différents laboratoires d'Anatomie Pathologique publiques et privés repartis dans cinq régions (centre, littoral, Ouest, Nord-ouest, Sud-ouest), pendant une période de 10 ans (2004-2013). Les paramètres étudiés étaient la fréquence, l’âge, le sexe, la localisation, le type et le grade histologique, et les récepteurs hormonaux. Un total de 3044 cas de cancers du sein a été recensé, soit une fréquence annuelle de 304,4 cas en moyenne. Le sexe féminin était le plus représenté avec 2971 cas (97,60%) et les hommes avec 73 cas (2,40%), soit un sexe ratio (H/F) de 0,02. L’âge moyen des patients était de 46±15,87 ans, avec des extrêmes de 13 et 95 ans. Selon la localisation, le sein gauche était atteint dans 1244 cas (52%) et le sein droit dans 1115 cas (47%). Au plan histologique, on retrouvait essentiellement des carcinomes avec 96,50% des cas, des sarcomes 1,39%, des lymphomes 1,07% et la maladie de Paget du mamelon, 1,03%. Les tumeurs épithéliales étaient infiltrantes dans 2049 cas (84,46%), avec une prédominance du carcinome canalaire infiltrant (1870 cas) et non infiltrantes dans 377 cas (15,54%). Le grade histo-pronostic de SBR avait révélé une prédominance du grade II dans 66% des cas. Les cancers du sein restent une pathologie fréquente au Cameroun et atteignent principalement la population féminine en âge de procréer. Ils sont caractérisés par la prédominance du carcinome canalaire infiltrant. PMID:26523182

La participation des enfants et des adolescents à la boxe

PubMed Central

Purcell, Laura K; LeBlanc, Claire MA

2012-01-01

RÉSUMÉ Des milliers de garçons et de filles de moins de 19 ans font de la boxe en Amérique du Nord. Même si la boxe comporte des avantages pour ceux qui y participent, y compris l’exercice, l’autodiscipline et la confiance en soi, le sport lui-même favorise et récompense des coups délibérés à la tête et au visage. Les personnes qui font de la boxe risquent de subir des blessures à la tête, au visage et au cou, y compris des traumatismes neurologiques chroniques et même fatals. Les commotions cérébrales sont l’une des principales blessures causées par la boxe. En raison du risque de blessures crâniennes et faciales, la Société canadienne de pédiatrie et l’American Academy of Pediatrics s’opposent vigoureusement à la boxe comme activité sportive pour les enfants et les adolescents. Ces organismes recommandent que les médecins s’élèvent contre la boxe auprès des jeunes et les encouragent à participer à d’autres activités dans lesquelles les coups intentionnels à la tête ne constituent pas un élément essentiel du sport.

Présentation de l’adaptation française de « l’échelle de coparentage » de McHale pour familles avec jeunes enfants

PubMed Central

Frascarolo, F.; Dimitrova, N.; Zimmermann, G.; Favez, N.; Kuersten-Hogan, R.; Baker, J.; McHale, J.

2009-01-01

Le but de cet article est de présenter l’autoquestionnaire américain de McHale permettant l’évaluation de la qualité du coparentage ainsi qu’un premier pas en direction de sa validation structurelle et de construit en langue française. Quarante et une familles suisses francophones et 84 familles nord-américaines ont rempli ce questionnaire ainsi qu’un autre portant sur leur satisfaction conjugale (Dyadic Adjustment Scale [DAS]). Les résultats des familles suisses correspondent aux résultats américains : d’une part, la distribution des items en quatre facteurs (intégrité familiale, conflit, affection et dénigrement) est retrouvée et, d’autre part, un lien relatif entre la qualité du coparentage et celle des relations conjugales est observé. Ce deuxième résultat confirme la validité de construit du questionnaire, vu le lien reconnu entre ces deux sous-systèmes. Étant donné l’influence de la qualité du coparentage sur le développement socio-affectif de l’enfant, disposer d’un outil permettant son évaluation, dans ses aspects tant positifs (soutien, chaleur, etc.) que négatifs (dénigrement, conflit, etc.), est un atout important aussi bien en recherche qu’en clinique. PMID:19655028

Analyse multi-échelle par ondelettes des contacts géologiques : application à la carte gravimétrique du Maroc nord-oriental

NASA Astrophysics Data System (ADS)

Khattach, Driss; Mraoui, Hamid; Sbibih, Driss; Chennouf, Touria

2006-06-01

The multiscale wavelet analysis has been applied to the gravity data from northeastern Morocco to map the major geological contacts, such us faults. Hence, the faults affecting the survey area were outlined with their importance level and dip direction. Seismic data confirm these results and testify the efficiency of this method, particularly in studying structure of plains. The structural map established is a very useful document in the planning of natural resources investigations (i.e. water, mines) to be undertaken in the area of study. To cite this article: D. Khattach et al., C. R. Geoscience 338 (2006).

Uranium deposits at Shinarump Mesa and some adjacent areas in the Temple Mountain district, Emery County, Utah

USGS Publications Warehouse

Wyant, Donald G.

1953-01-01

Deposits of uraniferous hydrocarbons are associated with carnotite in the Shinarump conglomerate of Triassic age at Shinarump Mesa and adjacent areas of the Temple Mountain district in the San Rafael Swell of Emery County, Utah. The irregular ore bodies of carnotite-bearing sandstone are genetically related to lenticular uraniferous ore bodies containing disseminated asphaltitic and humic hydrocarbon in permeable sandstones and were localized indirectly by sedimentary controls. Nearly non-uraniferous bitumen commonly permeates the sandstones in the Shinarump conglomerate and the underlying Moekopi formation in the area. The ore deposits at Temple Mountain have been altered locally by hydrothermal solutions, and in other deposits throughout the area carnotite has been transported by ground and surface water. Uraniferous asphaltite is thought to be the non-volatile residue of an original weakly uraniferous crude oil that migrated into the San Rafael anticline; the ore metals concentrated in the asphaltite as the oil was devolatilized and polymerized. Carnotite is thought to have formed from the asphaltite by ground water leaching. It is concluded that additional study of the genesis of the asphaltitic uranium ores in the San Rafael Swell, of the processes by which the hydrocarbons interact and are modified (such as heat, polymerization, and hydrogenation under the influence of alpha-ray bombardment), of petroleum source beds, and of volcanic intrusive rocks of Tertiary age are of fundamental importance in the continuing study of the uranium deposits on the Colorado Plateau.

Kinematics and thermal conditions in the permafrost-affected rockwalls of the Aiguille du Midi (3842 m a.s.l., Mont Blanc massif, France)

NASA Astrophysics Data System (ADS)

Ravanel, Ludovic; Grangier, Germain; Weber, Samuel; Beutel, Jan; Magnin, Florence; Gruber, Stefan; Deline, Philip

2016-04-01

Processes that control climate-dependent rockfall from permafrost-affected rock slopes are still poorly understood. In this study, we present the results of a Wireless Sensor Network, integrated within the Swiss project PermaSense and developed in 2012, to measure rock temperature and geotechnical parameters in the steep rockwalls of the Aiguille du Midi (AdM, 3842 m a.s.l., Mont Blanc massif, France). Accessible year round by cable car, the AdM comprises two main peaks: (i) the Piton Nord with the cable car arrival station, where 4 crack-meters are placed on four major fractures, and (ii) the Piton Central with many touristic infrastructure, equipped with three 10-m-deep boreholes with 15 temperatures sensors since 2009, and where 2 crack-meters are installed along a major fracture. Three major kinematic regimes are observed: (i) opening of clefts when the rock temperature becomes positive, followed by closing during the cold period, (ii) summer opening continued by a winter opening, and (iii) closing during the warm period followed by opening in winter.

Uraniferous opal, Virgin Valley, Nevada: conditions of formation and implications for uranium exploration

USGS Publications Warehouse

Zielinski, R.A.

1982-01-01

Uraniferous, fluorescent opal, which occurs in tuffaceous sedimentary rocks at Virgin Valley, Nevada, records the temperature and composition of uranium-rich solutions as well as the time of uranium-silica coprecipitation. Results are integrated with previous geologic and geochronologic data for the area to produce a model for uranium mobility that may be used to explore for uranium deposits in similar geologic settings. Uraniferous opal occurs as replacements of diatomite, or silicic air-fall ash layers in tuffaceous lakebeds of the Virgin Valley Formation (Miocene) of Merriam (1907). Fission-track radiography shows uranium to be homogeneously dispersed throughout the opal structure, suggesting coprecipitation of dissolved uranium and silica gel. Fluid inclusions preserved within opal replacements of diatomite have homogenization temperatures in the epithermal range and are of low salinity. Four samples of opal from one locality all have U-Pb apparent ages which suggest uraniferous opal precipitation in late Pliocene time. These ages correspond to a period of local, normal faulting, and highangle faults may have served as vertical conduits for transport of deep, thermalized ground water to shallower levels. Lateral migration of rising solutions occurred at intersections of faults with permeable strata. Silica and some uranium were dissolved from silica-rich host strata of 5-20 ppm original uranium content and reprecipitated as the solutions cooled. The model predicts that in similar geologic settings, ore-grade concentrations of uranium will occur in permeable strata that intersect high-angle faults and that contain uranium source rocks as well as efficient reductant traps for uranium. In the absence of sufficient quantities of reductant materials, uranium will be flushed from the system or will accumulate in low-grade disseminated hosts such as uraniferous opal. ?? 1982.

Distribution épidémiologique de l'infection à VIH chez les femmes enceintes dans les dix régions du Cameroun et implications stratégiques pour les programmes de prévention

PubMed Central

Billong, Serge-Clotaire; Fokam, Joseph; Billong, Edson-Joan; Nguefack-Tsague, Georges; Essi, Marie-Josée; Fodjo, Raoul; Sosso, Samuel-Martin; Gomba, Armelle; Mosoko-Jembia, Joseph; Loni-Ekali, Gabriel; Colizzi, Vittorio; Bissek, Anne-Cécile Zoung-Kani; Monebenimp, Francisca; Nfetam, Jean-Bosco Elat

2015-01-01

Introduction Le Cameroun se situe dans un contexte d’épidémie généralisée du VIH. La sous-population des femmes enceintes, facilement accessible au sein de la population générale, représente une cible probante pour mener la surveillance du VIH et estimer l’évolution épidémiologique. L'objectif de notre étude était d’évaluer la distribution épidémiologique du VIH chez les femmes enceintes. Méthodes Étude transversale menée en 2012 chez 6521 femmes enceintes (49,3% âgées de 15-24 ans) en première consultation prénatale (CPN1) dans 60 sites des 10 régions Camerounaises. L'algorithme en série a été utilisé pour le sérodiagnostic du VIH. Résultats La prévalence du VIH était de 7,8% (508/6521), avec une différence non significative (p = 0,297) entre milieu rural (7,4%) et milieu urbain (8,1%). En zone rurale, cette prévalence variait de 0,7% à l'Extrême-Nord à 11,8% au Sud. Cependant, en zone urbaine elle variait de 4% à l'Ouest à 11,1% au Sud-Ouest. Suivant l’âge, la prévalence était plus élevée (11,3%) chez les femmes de 35-39 ans. Suivant le niveau de scolarisation, la prévalence du VIH était plus faible (4,4%) chez celles non-scolarisées, et plus élevée (9,3%) chez celles ayant un niveau primaire. Selon la profession, l'infection était plus élevée chez les coiffeuses (15,5%), secrétaires (14,8%), commerçantes (12,9%) et institutrices/enseignantes (10,8%). Conclusion La prévalence du VIH reste élevée chez les femmes enceintes au Cameroun, sans distinction entre milieux rural et urbain. Les stratégies de prévention devraient s'orienter préférentiellement chez les femmes enceintes âgées, celles du niveau d'instruction primaire, et celles du secteur des petites et moyennes entreprises. PMID:26090037

Profil étiologique des surdités neurosensorielle sévère et profonde de l'enfant dans la région du centre-nord du Maroc

PubMed Central

Ridal, Mohammed; Outtasi, Naouar; Taybi, Zainab; Boulouiz, Redouan; Chaouki, Sanae; Boubou, Meryem; Maaroufi, Mustapha; Benmansour, Najib; Zaki, Zouheir; Ouldim, Karim; Barakat, Hamid; Hida, Mustapha; Tizniti, Siham; El Alami, Mohamed Noreddine

2014-01-01

Introduction Le diagnostic d'une surdité profonde est possible dès les premiers jours de vie. Or, le développement du langage et l'intégration scolaire et professionnelle ne sont pas possible que si la surdité est prise en charge précocement. L’établissement d'un diagnostc étiologique a des implications pronostiques et thérapeutiques. Méthodes C'est une étude rétrospective allant de Juin 2009 au mois de Janvier 2012 ayant recensé 250 cas d'enfants porteurs d'une surdité sévère et profonde. Résultats La moyenne d’âge au moment de l'annonce du diagnostic est de 3.7 ans. Les étiologies prédominantes sont les surdités génétiques dans 35.6% suivies des surdités acquises dans 30.8% des cas. Dans 34.4% des cas aucune étiologie n'a pu être retrouvée. Conclusion Cette étude met en évidence la prédominance éventuelle de causes génétiques de la surdité neurosensorielle de l'enfant au Maroc, et souligne la nécessité d'améliorer les politiques de prévention des maladies infectieuses et de dépistage de la surdité néonatale. Cependant, des analyses moléculaires plus ciblées et la réalisation d'un scanner des rochers systématiques sont nécessaires pour évaluer plus précisément la contribution des étiologies génétiques. PMID:25018837

Thrombasthénie de Glanzmann: à propos de 11 cas

PubMed Central

Mukendi, Jean-Louis Ntumba; Benkirane, Souad; Masrar, Azlarab

2015-01-01

Introduction La thrombasthénie de Glanzmann est une pathologie hémorragique héréditaire rare due à une déficience ou un dysfonctionnement du complexe glycoprotéique IIb/IIIa de la membrane plaquettaire. Le but de notre étude est de décrire les caractéristiques démographiques, cliniques et biologiques d'une série de patients atteints de thrombasthénie de Glanzmann. Méthodes C'est une étude portant sur tous les patients atteints de thrombasthénie de Glanzmann diagnostiqués au Laboratoire Central d'Hématologie du Centre Hospitalier Ibn Sina de Rabat au Maroc pendant la période allant du 1er mars 2011 au 31 mars 2013, soit 25 mois. Après avoir recueilli les données épidémiologiques et cliniques de nos patients, nous avons réalisé une étude biologique comportant une numération plaquettaire et une agrégométrie. Résultats 11 patients ont présenté des profils agrégométriques compatibles à une TG. La majorité de ces malades étaient issus de mariages consanguins (54,5%) et originaires de régions situées dans le nord du Maroc. Le syndrome hémorragique s'est révélé principalement cutanéo-muqueux, avec une prédominance des gingivorragies (72,7%), des épistaxis (63,6%) et des ecchymoses (45,5%). Conclusion Nos résultats ont montré que la thrombasthénie de Glanzmann est une pathologie relativement fréquente au Maroc. PMID:26587119

Essai de corrélations séquentielles au Barrémien-Aptien dans un système plateforme-bassin-plateforme le long d'un transect Danube-Gabrovo (Bulgarie du Centre-Nord)

NASA Astrophysics Data System (ADS)

Ivanov, Marin; Peybernès, Bernard; Nikolov, Todor; Ciszak, Richard; Stoykova, Krystalina; Minkovska, Vera

1997-12-01

Along a Danube-Gabrovo cross-section, from Central Fore Balkan to Moesian Platform, the Barremian-Aptian deposits are distributed within three distinct paleogeographic domains: a central terrigenous: basin (Pleven-Polski Trămbeš) and, laterally (N: Danube, S: Gabrovo) two carbonate-dominated platforms where "Urgonian" fades can be well-developed. This pattern is induced by synsedimentary extensional tectonics already active from the end of Jurassic times. The subdivision of the various series into eight 3 d order depositional sequences and the recent discovery of ammonites allow us to propose new and more reliable correlations between the traditional lithologic formations characterizing those three domains.

Renaud Paulian et le programme du CNRS sur les hautes montagnes à Madagascar: étage vs domaine

PubMed Central

Guillaumet, Jean-Louis; Betsch, Jean-Marie; Callmander, Martin W.

2011-01-01

Résumé Le programme intitulé « Étude des écosystémes montagnards dans la région malgache» (RCP 225/CNRS; responsable: Recteur Renaud Paulian) avait pour ambition de dégager leurs caractères généraux, l'origine des éléments constitutifs et de tester la validité d'un Domaine malgache des Hautes Montagnes proposé par Humbert dès 1951. De 1970 à 1973, trois campagnes (Andringitra; Chaînes anosyennes et Ankaratra; Itremo, Ibity et Marojejy) ont permis une caractérisation écologique des milieux particuliers ainsi que des analyses de systématique sur certains taxa connus pour leur intérêt biogéographique. La succession altitudinale des formations végétales, définies par des critères physionomiques et structuraux, est précisée par massif. Le dernier étage caractérisé par le fourré éricoïde et ses groupements associés ne correspond pas à l'Étage des Hautes Montagnes de l'Est africain. Des groupes de la faune (invertébrés hexapodes: Collemboles et Dermaptères) indiquent une disjonction entre les massifs du Nord (Tsaratanana, Marojejy), ceux du Centre et du Sud; des éléments de la flore (Pandanaceae, Araliaceae, Asteraceae) sont en cours d'analyse dans le même sens. Le Domaine des Hautes montagnes à Madagascar est une réalité écologique mais ne peut être défini floristiquement; chaque massif montagneux est une entité phytogéographique d'étages de végétation interdépendants inclus dans les différents Sous-Domaines du Centre. Les groupes peu mobiles de la faune indiquent globalement une dépendance trophique et bioclimatique (effet tampon du climat intraforestier) vis-à-vis des étages de végétation, mais peuvent réagir à des microclimats locaux par des décalages à leurs limites. PMID:21731422

Quantitative trait loci for live animal and carcass composition traits in Jersey and Limousin back-cross cattle finished on pasture or feedlot.

PubMed

Morris, C A; Pitchford, W S; Cullen, N G; Esmailizadeh, A K; Hickey, S M; Hyndman, D; Dodds, K G; Afolayan, R A; Crawford, A M; Bottema, C D K

2009-10-01

A quantitative trait locus (QTL) study was carried out in two countries, recording live animal and carcass composition traits. Back-cross calves (385 heifers and 398 steers) were generated, with Jersey and Limousin breed backgrounds. The New Zealand cattle were reared on pasture to carcass weights averaging 229 kg, whilst the Australian cattle were reared on grass and finished on grain (for at least 180 days) to carcass weights averaging 335 kg. From 11 live animal traits and 31 carcass composition traits respectively, 5 and 22 QTL were detected in combined-sire analyses, which were significant (P < 0.05) on a genome-wise basis. Fourteen significant traits for carcass composition QTL were on chromosome 2 and these were traits associated with muscling and fatness. This chromosome carried a variant myostatin allele (F94L), segregating from the Limousin ancestry. Despite very different cattle management systems between the two countries, the two populations had a large number of QTL in common. Of the 18 traits which were common to both countries, and which had significant QTL at the genome-wise level, eight were significant in both countries.

Comparison of composition and quality traits of meat from young finishing bulls from Belgian Blue, Limousin and Aberdeen Angus breeds.

PubMed

Cuvelier, C; Clinquart, A; Hocquette, J F; Cabaraux, J F; Dufrasne, I; Istasse, L; Hornick, J L

2006-11-01

Thirty-six young finishing bulls from three breeds (Belgian Blue, Limousin and Aberdeen Angus) were fattened over five months with finishing diets based either on sugar-beet pulp or on cereals. Nutritional quality traits of meat - fat content and fatty acid composition with emphasis on the n-6 and n-3 polyunsaturated fatty acids - along with some organoleptic quality traits were measured. The Belgian Blue bulls had the lowest intramuscular fat content associated with lower saturated and monounsaturated fatty acid contents. The polyunsaturated fatty acid content did not differ to a large extent between the breeds, the Aberdeen Angus bulls showing slightly higher values. Relative to energy intake, the overall contribution of meat to the n-3 fatty acid recommended intake was small, whatever the breed. By contrast, the contribution of meat to daily fat intake was of greater importance, especially for the Aberdeen Angus bulls. The quality traits of meat varied also according to the breed: compared to the Aberdeen Angus, the Belgian Blue bull meat had the stablest colour, the highest drip and the lowest cooking losses. The meat of Limousin bulls had intermediate characteristics for all the parameters.

Effect of humid tropical climate on the thermoregulatory response of Limousin × Creole and Creole growing bulls in Guadeloupe (French West Indies)

NASA Astrophysics Data System (ADS)

Berbigier, P.; Sergent, D.; Sophie, S. A.; Barlet, J. P.; Decoux, G.

1987-03-01

In Guadeloupe (French West Indies), eight Limousin × Creole (local) growing bulls and eight Creole bulls were either exposed to full sunshine or shaded; each climatic treatment involved half of the animals of each breed. All the bulls were fed ad libitum on a concentrate diet. Twice a week, around 12 a.m., respiratory rhythm, rectal temperature, heart rate as well as microclimatic parameters (mainly black globe temperature) were measured and a blood sample taken for packed cell volume, prolactin, and triiodothyronin (T3) plasma concentration determination. Respiratory rhythm and, to a lesser extent, rectal temperature were found to increase more for the Limousin × Creole crossbred than for the Creole bull on exposure to the sun and rise in globe temperature. However, the heart rate and blood parameters in the crossbred did not seem seriously affected by heat. This seems to indicate that the crossbred animals, though they required more positive thermal regulation than the local cattle, are not heat-stressed in the West Indian conditions. These findings are also supported by the lack of effect of exposure to the sun on the growth and carcass characteristics of such animals (reported elsewhere).

Lead isotope ratios in bone ash of blesbok (Damaliscus pygargus phillipsi): a means of screening for the accumulation of contaminants from uraniferous rocks.

PubMed

Nöthling, Johan O; Du Toit, Johannes S; Myburgh, Jan G

2014-09-19

This study was done to determine whether blesbok (Damaliscus pygargus phillipsi) from the Krugersdorp Game Reserve (KGR) in Gauteng Province, South Africa have higher concentrations of (238)U and higher (206)Pb/(204)Pb and (207)Pb/(204)Pb ratios in their bone ash than blesbok from a nearby control reserve that is not exposed to mine water and has no outcrops of uraniferous rocks. Eight blesbok females from the KGR and seven from the control site, all killed with a brain shot, were used. A Thermo X-series 2 quadrupole ICPMS was used to measure the concentrations of (238)U and lead and a Nu Instruments NuPlasma HR MC-ICP-MS to measure the lead isotope ratios in the tibial ash from each animal. KGR blesbok had higher mean concentrations of (238)U (P = 0.02) and ratios of (206)Pb/(204)Pb and (207)Pb/(204)Pb (P < 0.00001) than the control blesbok. The probability of rejecting the false null hypothesis of no difference in the (206)Pb/(204)Pb or (207)Pb/(204)Pb ratios between KGR and control reserve animals (the power of the test) was 0.999. The blesbok from the KGR accumulated contaminants from an uraniferous environment. The (206)Pb/(204)Pb and (207)Pb/(204)Pb ratios in tibial ash proved effective in confirming accumulation of contaminants from uraniferous rocks.

Strategy for managing water in the Middle East and North Africa; Strategie pour la gestion de l`eau au moyen-orient et en afrique du nord

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-07-01

Water has always been of central concern to life in the Middle East and North Africa (MENA). Burgeoning populations are placing unprecendented pressures on the resource, calling urgently for new approaches to water planning and management if escalating conflicts are to be avoided and if environmental degradation is to be reversed. The booklet sets out the implications of the new Bank policy for the MENA region, calling for a concerted effort by government and Bank staff to address water resources in a coordinated and sustainable manner. It proposes a practical, step-by-step approach to achieving this objective that could lead tomore » new Bank-supported operations to address the water sector as a whole.« less

Impacts de l`élévation du niveau de la mer sur l'évolution future d'une côte basse à lagune de la péninsule du Cap Bon (Nord-Est de la Tunisie): approche cartographique

NASA Astrophysics Data System (ADS)

Brahmi, Noura; Dhieb, Mohsen; Chedly Rabia, Mohamed

2018-05-01

La submersion marine est l'une des principales menaces qui pèsent sur les zones humides littorales de la péninsule du Cap Bon. Or, cette menace est amenée à se renforcer en raison du réchauffement climatique qui entraînera une élévation du niveau marin et vraisemblablement un renforcement de l'intensité des tempêtes et des cyclones tropicaux d'ici à l'horizon 2100. L'objectif a donc été d'évaluer la vulnérabilité de la lagune face à la submersion. Dans cette optique, après avoir identifié les enjeux liés à l'élévation du niveau de la mer pour la lagune, nous avons dressé une cartographie prévisionnelle des risques de submersion par l'intermédiaire d'une application cartographique basée sur une modélisation numérique de terrain et analysé les impacts potentiels de ce phénomène. La cartographie est donc amenée à devenir centrale pour l'étude de l'impact du risque de la submersion marine sur les lagunes côtières et la gestion de ces espaces dans les décennies à venir. La cartographie de l'aléa submersion marine a montré que l'ouverture épisodique de brèches lors des tempêtes pourrait entraîner la submersion de l'ensemble du domaine lagunaire et aurait un impact morphogénique essentiel. En effet, le phénomène d'une accélération de l'élévation du niveau marin et d'un renforcement des tempêtes génère le morcellement du cordon littoral qui sépare la lagune de la mer. Par ailleurs, les pertes de matériel sédimentaire pour la plage augmenteront, dans la mesure où, lors d'une tempête, une grande partie des matériaux déplacés par les vagues dans les étangs par submersion ou par ouverture d'une brèche, ne peut être récupérée par la suite. Tout ceci constitue un facteur d'accélération du recul ou de disparition de la plage déjà très érodée. Les impacts de cette submersion pourraient être importants en absence de mesures préventives. Elle aurait ainsi des répercussions profondes sur les systèmes naturels et environnementaux et sur la qualité de vie de la population locale.

Contributions de la geographie et de la modelisation predictive a une etude de potentiel archeologique prehistorique en Gaspesie

NASA Astrophysics Data System (ADS)

Desrosiers, Marc

La Gaspésie, région péninsulaire à l'extrême est du Québec, possède un héritage archéologique préhistorique riche qui s'étend de 9 000 ans jusqu'à 450 ans avant aujourd'hui. L'archéologie a livré de nombreux sites préhistoriques dans la région, surtout dans le nord de la péninsule, un constat en partie attribuable à la présence de sources de matières premières lithiques, d'axes de circulation potentielles, mais aussi à la répartition spatiale inégale des efforts de recherche. L'étude du potentiel archéologique préhistorique gaspésien, c'est la première étape de la démarche archéologique, est donc nécessaire pour orienter les travaux futurs dans cette région. Trois secteurs représentatifs de la Gaspésie ont été étudiés pour développer une nouvelle approche d'étude de potentiel : Sainte-Anne-des-Monts, le lac Sainte-Anne et New Richmond. Ensemble, ces secteurs s'étirent au travers de la péninsule sur un axe nord-sud et correspondent à un possible axe de circulation préhistorique. L'évaluation du potentiel archéologique de ces aires d'étude dépend notamment de contexte géographique gaspésien. Celui-ci est complexe, particulièrement depuis la déglaciation qui a engendré une succession de transformations du paysage. Les variations du niveau marin relatif, le passage de la toundra à un milieu forestier et d'autres changements environnementaux ont conditionné la façon dont les populations préhistoriques se sont adaptées au territoire. L'étude de potentiel dépend également des connaissances archéologiques existantes pour la région, car elles conditionnent la sélection de variables environnementales représentatives des sites connus. À partir de la confrontation des données géographiques et archéologiques, nous avons proposé des schèmes d'établissement pour les périodes chronoculturelles de la préhistoire gaspésienne. Ces patrons informationnels permettent d'illustrer la façon dont les populations préhistoriques occupaient le territoire gaspésien. C'est en appliquant ces schèmes d'établissement dans un SIG (Système d'Information Géographique) qu'il est alors possible de modéliser l'occupation potentielle du territoire au cours des périodes de la préhistoire gaspésienne. Les résultats de la modélisation sont prometteurs car les sites archéologiques connus dans le secteur de Sainte-Anne-des-Monts correspondent aux secteurs à potentiel élevé proposés par la modélisation, bien qu'une validation géomorphologique de la modélisation soit nécessaire à une étape ultérieure. Les deux autres secteurs ne présentaient pas de sites archéologiques datés qui permettaient de valider la modélisation à ces endroits. L'outil proposé est d'autant plus intéressant qu'il permet d'étudier rapidement de vastes territoires au potentiel archéologique mal évalué, comme c'est le cas de la Gaspésie.

Effect of mineral constituents in the bioleaching of uranium from uraniferous sedimentary rock samples, Southwestern Sinai, Egypt.

PubMed

Amin, Maisa M; Elaassy, Ibrahim E; El-Feky, Mohamed G; Sallam, Abdel Sattar M; Talaat, Mona S; Kawady, Nilly A

2014-08-01

Bioleaching, like Biotechnology uses microorganisms to extract metals from their ore materials, whereas microbial activity has an appreciable effect on the dissolution of toxic metals and radionuclides. Bioleaching of uranium was carried out with isolated fungi from uraniferous sedimentary rocks from Southwestern Sinai, Egypt. Eight fungal species were isolated from different grades of uraniferous samples. The bio-dissolution experiments showed that Aspergillus niger and Aspergillus terreus exhibited the highest leaching efficiencies of uranium from the studied samples. Through monitoring the bio-dissolution process, the uranium grade and mineralogic constituents of the ore material proved to play an important role in the bioleaching process. The tested samples asserted that the optimum conditions of uranium leaching are: 7 days incubation time, 3% pulp density, 30 °C incubation temperature and pH 3. Both fungi produced the organic acids, namely; oxalic, acetic, citric, formic, malonic, galic and ascorbic in the culture filtrate, indicating an important role in the bioleaching processes. Copyright © 2014 Elsevier Ltd. All rights reserved.

PubMed

Guillaumet, Jean-Louis; Betsch, Jean-Marie; Callmander, Martin W

2008-01-01

Le programme intitulé « Étude des écosystémes montagnards dans la région malgache» (RCP 225/CNRS; responsable: Recteur Renaud Paulian) avait pour ambition de dégager leurs caractères généraux, l'origine des éléments constitutifs et de tester la validité d'un Domaine malgache des Hautes Montagnes proposé par Humbert dès 1951. De 1970 à 1973, trois campagnes (Andringitra; Chaînes anosyennes et Ankaratra; Itremo, Ibity et Marojejy) ont permis une caractérisation écologique des milieux particuliers ainsi que des analyses de systématique sur certains taxa connus pour leur intérêt biogéographique. La succession altitudinale des formations végétales, définies par des critères physionomiques et structuraux, est précisée par massif. Le dernier étage caractérisé par le fourré éricoïde et ses groupements associés ne correspond pas à l'Étage des Hautes Montagnes de l'Est africain. Des groupes de la faune (invertébrés hexapodes: Collemboles et Dermaptères) indiquent une disjonction entre les massifs du Nord (Tsaratanana, Marojejy), ceux du Centre et du Sud; des éléments de la flore (Pandanaceae, Araliaceae, Asteraceae) sont en cours d'analyse dans le même sens. Le Domaine des Hautes montagnes à Madagascar est une réalité écologique mais ne peut être défini floristiquement; chaque massif montagneux est une entité phytogéographique d'étages de végétation interdépendants inclus dans les différents Sous-Domaines du Centre. Les groupes peu mobiles de la faune indiquent globalement une dépendance trophique et bioclimatique (effet tampon du climat intraforestier) vis-à-vis des étages de végétation, mais peuvent réagir à des microclimats locaux par des décalages à leurs limites.

Etude de la performance des radars hautes-frequences CODAR et WERA pour la mesure des courants marins en presence partielle de glace de mer

NASA Astrophysics Data System (ADS)

Kamli, Emna

Les radars hautes-frequences (RHF) mesurent les courants marins de surface avec une portee pouvant atteindre 200 kilometres et une resolution de l'ordre du kilometre. Cette etude a pour but de caracteriser la performance des RHF, en terme de couverture spatiale, pour la mesure des courants de surface en presence partielle de glace de mer. Pour ce faire, les mesures des courants de deux radars de type CODAR sur la rive sud de l'estuaire maritime du Saint-Laurent, et d'un radar de type WERA sur la rive nord, prises pendant l'hiver 2013, ont ete utilisees. Dans un premier temps, l'aire moyenne journaliere de la zone ou les courants sont mesures par chaque radar a ete comparee a l'energie des vagues de Bragg calculee a partir des donnees brutes d'acceleration fournies par une bouee mouillee dans la zone couverte par les radars. La couverture des CODARs est dependante de la densite d'energie de Bragg, alors que la couverture du WERA y est pratiquement insensible. Un modele de fetch appele GENER a ete force par la vitesse du vent predite par le modele GEM d'Environnement Canada pour estimer la hauteur significative ainsi que la periode modale des vagues. A partir de ces parametres, la densite d'energie des vagues de Bragg a ete evaluee pendant l'hiver a l'aide du spectre theorique de Bretschneider. Ces resultats permettent d'etablir la couverture normale de chaque radar en absence de glace de mer. La concentration de glace de mer, predite par le systeme canadien operationnel de prevision glace-ocean, a ete moyennee sur les differents fetchs du vent selon la direction moyenne journaliere des vagues predites par GENER. Dans un deuxieme temps, la relation entre le ratio des couvertures journalieres obtenues pendant l'hiver 2013 et des couvertures normales de chaque radar d'une part, et la concentration moyenne journaliere de glace de mer d'autre part, a ete etablie. Le ratio des couvertures decroit avec l'augmentation de la concentration de glace de mer pour les deux types de radars, mais pour une concentration de glace de 20% la couverture du WERA est reduite de 34% alors que pour les CODARs elle est reduite de 67%. Les relations empiriques etablies entre la couverture des RHF et les parametres environnementaux (vent et glace de mer) permettront de predire la couverture que pourraient fournir des RHF installes dans d'autres regions soumises a la presence saisonniere de glace de mer.

Epidemiology of Traumatic Injuries in the Northeast Region of Haiti: A Cross-sectional Study.

PubMed

Aluisio, Adam R; De Wulf, Annelies; Louis, Ambert; Bloem, Christina

2015-12-01

More than 90% of traumatic morbidity and mortality occurs in low- and middle-income countries (LMIC). Haiti is the poorest country in the Western Hemisphere and lacks contemporary statistics on the epidemiology of traumatic injuries. This study aimed to characterize the burden of traumatic injuries among emergency department patients in the Northeast region of Haiti. Data were collected from the emergency departments of all public hospitals in the Northeast region of Haiti, which included the Fort Liberté, Ouanaminthe, and Trou du Nord sites. All patients presenting for emergent care of traumatic injuries were included. Data were obtained via review of emergency department registries and patient records from October 1, 2013 through November 30, 2013. Data on demographics, mechanisms of trauma, and anatomical regions of injury were gathered using a standardized tool and analyzed using descriptive statistics. Temporal analysis of injury frequency was explored using regression modeling. Data from 383 patient encounters were accrued. Ouanaminthe Hospital treated the majority of emergent injuries (59.3%), followed by Fort Liberté (30.3%) and Trou du Nord (10.4%). The median age in years was 23 with 23.1% of patients being less than 15 years of age. Road traffic accidents (RTAs) and interpersonal violence accounted for 65.8% and 30.1% of all traumatic mechanisms, respectively. Extremity trauma was the most frequently observed anatomical region of injury (38.9%), followed by head and neck (30.3%) and facial (19.1%) injuries. Trauma due to RTA resulted in a single injury (83.8%) to either an extremity or the head and neck regions most frequently. A minority of patients had medical record documentation (37.9%). Blood pressure, respiratory rate, and mental status were documented in 19.3%, 4.1%, and 0.0% of records, respectively. There were 6.3 injuries/day during the data collection period with no correlation between the frequency of emergent trauma cases and day of the week (R(^2)=0.01). Traumatic injuries are a common emergent presentation in the Northeast region of Haiti with characteristics similar to other LMIC. Documentation and associated data to adequately characterize the burden of disease in this region are lacking. Road traffic accidents are the predominate mechanism of injury, suggesting that interventions addressing prevention and treatment of this common occurrence may provide public health benefits in this setting.

Teaching Religion in Public Schools: Review of Warren A. Nord, "Does God Make a Difference?"

ERIC Educational Resources Information Center

Feinberg, Walter

2013-01-01

In this review of Warren Nord's "Does God Make a Difference? Taking Religion Seriously in Our Schools and Universities," Walter Feinberg provides a detailed analysis of Nord's argument that the study of religion should be constitutionally mandated as a corrective to the overwhelmingly secular course of study offered in…

Improving Word Similarity by Augmenting PMI with Estimates of Word Polysemy

DTIC Science & Technology

2011-12-29

radiator, brake , throttle, speeding, uptown, curb, auto, skid, balloon, truck, refrigerator, driver, downtown, parachute, gasoline, steering, spin...chauffeur, garage, motor, trolley, locomotive, conductor, automobile, limousine, freight, headlight, train, driver, brake , siding, passenger, engine

Teledetection passive et processus decisionnel a reference spatiale: Application a l'aquaculture en milieu marin

NASA Astrophysics Data System (ADS)

Habbane, Mohamed

L'objectif de cette etude est d'elaborer un processus decisionnel a reference spatiale (PDRS) pour la mariculture. Le PDRS est applique aux eaux cotieres de la baie des Chaleurs, dans le golfe du Saint-Laurent (Canada). Une carte preliminaire regionale d'indices du potentiel maricole, d'une limite de resolution spatiale de 1 kmsp2, est produite avec des parametres du niveau 1. Ces parametres englobent la temperature de l'eau de surface, extraite des images AVHRR, la salinite, les courants ainsi que les pigments chlorophylliens, quantifies a l'aide de mesures in situ. Les images AVHRR, prises en 1994, ont ete utiliees comme reference primaire pour selectionner des aires pouvant supporter une activite maricole sur la cote nord de la baie des Chaleurs. La temperature de surface extraite de ces images permet une analyse mesoechelle a la fois qualitative et quantitative des processus cotiers observes pendant la periode d'acquisition des donnees. Les autres donnees, soit la salinite, les courants et les concentrations en pigments chlorophylliens, sont analysees de facon a identifier la variabilite spatio-temporelle des caracteristiques des eaux de surface. L'ensemble des informations permet de produire une carte preliminaire regionale d'indices du potentiel maricole de la partie centrale de la baie des Chaleurs. Selon cet indice (defini entre 0 et 1), le secteur de potentiel aquicole de 0,5 a 0,75 s'etend sur une superficie d'environ 300 kmsp2. La localisation de cette aire potentielle est en accord avec les fortes concentrations en pigments chlrophylliens, presentant des conditions environnementales ideales a une haute productivite biologique. Par la suite la carte preliminaire est modifiee en tenant compte des parametres du niveau 2. Ces parametres sont la geomorphologie littorale, la bathymetrie, les sediments en suspension, les vents, les vagues, le debit d'eau douce, la glace marine, le carbone organique dissous, les aires de peche et les sources de pollution. Ces parametres sont compares deux a deux par rapport a la carte preliminaire regionale d'indices du potentiel maricole pour determiner leur poids relatif. La carte finale produite avec ces parametres du niveau 2 presente un secteur ou les indices du potentiel maricole sont de 0,5 a 0,75. Ce secteur longe la cote et epouse les isobathes de 10 a 30 m de profondeur. L'effet de la profondeur d'eau semble avoir jouer un role important. Le secteur de potentiel maricole de 0,25 a 0,5 est toujours present et couvre une superficie d'environ 426 kmsp2. L'etude necessitera toujours un suivi des conditions environnementales prevalant dans la region. Ce suivi peut etre effectue a l'aide d'un outil de vision aerospatiale (capteurs de teledetection) et d'analyse spatio-temporelle (SIG-PDRS). (Abstract shortened by UMI.)

Caractéristiques et signification d'un niveau coquillier majeur à brachiopodes, marqueur événementiel dans l'évolution dévonienne de la Saoura (Sahara du Nord-Ouest, Algérie)

NASA Astrophysics Data System (ADS)

Ouali Mehadji, Abdelkader; Elmi, Serge; Rachebœuf, Patrick; Mekahli, Larbi

2004-11-01

In the Saoura, the brachiopod shell beds, so-called niveau coralligène, correspond to a major shell deposit dated to the Late Emsian. Brachiopods and crinoids dominate the benthic assemblage that contains also corals, bryozoans, trilobites, goniatites, and orthocones. This major level has a large geographic distribution and it is characterized by a wide brachiopod diversity due to time-averaging, taphonomic feedback and alternate bottom conditions changing from soft to shelly and firm. This kind of brachiopod association is linked to a transgressive onlap system. At regional extent, we can correlate this major shell bed to similar shell deposits from the Ahnet-Mouydir, Tindouf, and Zemmour areas. It indicates an important transgressive event underlined by change in the sedimentation from detritic deposits to carbonate sediments. To cite this article: A. Ouali Mehadji et al., C. R. Geoscience 336 (2004).

Evolution and molecular epidemiology of classical swine fever virus during a multi-annual outbreak amongst European wild boar.

PubMed

Goller, Katja V; Gabriel, Claudia; Dimna, Mireille Le; Le Potier, Marie-Frédérique; Rossi, Sophie; Staubach, Christoph; Merboth, Matthias; Beer, Martin; Blome, Sandra

2016-03-01

Classical swine fever is a viral disease of pigs that carries tremendous socio-economic impact. In outbreak situations, genetic typing is carried out for the purpose of molecular epidemiology in both domestic pigs and wild boar. These analyses are usually based on harmonized partial sequences. However, for high-resolution analyses towards the understanding of genetic variability and virus evolution, full-genome sequences are more appropriate. In this study, a unique set of representative virus strains was investigated that was collected during an outbreak in French free-ranging wild boar in the Vosges-du-Nord mountains between 2003 and 2007. Comparative sequence and evolutionary analyses of the nearly full-length sequences showed only slow evolution of classical swine fever virus strains over the years and no impact of vaccination on mutation rates. However, substitution rates varied amongst protein genes; furthermore, a spatial and temporal pattern could be observed whereby two separate clusters were formed that coincided with physical barriers.

Genetic variability of six French meat sheep breeds in relation to their genetic management.

PubMed

Huby, Marie; Griffon, Laurent; Moureaux, Sophie; De Rochambeau, Hubert; Danchin-Burge, Coralie; Verrier, Etienne

2003-01-01

Some demographic parameters, the genetic structure and the evolution of the genetic variability of six French meat sheep breeds were analysed in relation with their management. Four of these breeds are submitted to more or less intense selection: the Berrichon du Cher (BCH), Blanc du Massif Central (BMC), Charollais (CHA) and Limousin (LIM); the other two breeds are under conservation: the Roussin de La Hague (RLH) and Solognot (SOL). Genealogical data of the recorded animals born from 1970 to 2000 and of their known ancestors were used. The most balanced contributions of the different flocks to the sire-daughter path was found in the SOL. In the BCH, a single flock provided 43% of the sire-AI sire path, whereas the contributions of the flocks were more balanced in the BMC and LIM (the only other breeds where AI is used to a substantial amount). The distribution of the expected genetic contribution of the founder animals was found to be unbalanced, especially in the BCH and LIM. The effective numbers of ancestors (founders or not) for the ewes born from 1996 to 2000 were equal to 35 (BCH), 144 (BMC), 112 (CHA), 69 (LIM), 40 (RLH) and 49 (SOL). Inbreeding was not analysed in the BMC, due to incomplete pedigree information. From 1980 on, the rates of inbreeding, in percentage points per year, were +0.112 (BCH), +0.045 (CHA), +0.036 (LIM), +0.098 (RLH) and +0.062 (SOL). The implications of the observed trends on genetic variability are discussed in relation to the genetic management of each breed. The need for a larger selection basis in the BCH, the efficiency of the rules applied in the SOL to preserve the genetic variability and the need for a more collective organisation in the CHA and RLH are outlined.

Hereditary Spastic Paraplegia

MedlinePlus

... Mail: 800-999-NORD (6673) Spastic Paraplegia Foundation 1605 Goularte Place Fremont CA Fremont, CA 94539-7241 ... Mail: 800-999-NORD (6673) Spastic Paraplegia Foundation 1605 Goularte Place Fremont CA Fremont, CA 94539-7241 ...

Quantitative trait loci for organ weights and adipose fat composition in Jersey and Limousin back-cross cattle finished on pasture or feedlot.

PubMed

Morris, C A; Bottema, C D K; Cullen, N G; Hickey, S M; Esmailizadeh, A K; Siebert, B D; Pitchford, W S

2010-12-01

A QTL study of live animal and carcass traits in beef cattle was carried out in New Zealand and Australia. Back-cross calves (385 heifers and 398 steers) were generated, with Jersey and Limousin backgrounds. This paper reports on weights of eight organs (heart, liver, lungs, kidneys, spleen, gastro-intestinal tract, fat, and rumen contents) and 12 fat composition traits (fatty acid (FA) percentages, saturated and monounsaturated FA subtotals, and fat melting point). The New Zealand cattle were reared and finished on pasture, whilst Australian cattle were reared on grass and finished on grain for at least 180 days. For organ weights and fat composition traits, 10 and 12 significant QTL locations (P<0.05), respectively, were detected on a genome-wide basis, in combined-sire or within-sire analyses. Seven QTL significant for organ weights were found at the proximal end of chromosome 2. This chromosome carries a variant myostatin allele (F94L), segregating from the Limousin ancestry, and this is a positional candidate for the QTL. Ten significant QTL for fat composition were found on chromosomes 19 and 26. Fatty acid synthase and stearoyl-CoA desaturase (SCD1), respectively, are positional candidate genes for these QTL. Two FA QTL found to be common to sire groups in both populations were for percentages of C14:0 and C14:1 (relative to all FAs) on chromosome 26, near the SCD1 candidate gene. © 2010 AgResearch Ltd, Animal Genetics © 2010 Stichting International Foundation for Animal Genetics.

[Molecular strain typing contribution to epidemiology of tuberculosis in Limousin (1998 to 2006)].

PubMed

Bezanahary, H; Baclet, M-C; Sola, C; Gazaille, V; Turlure, P; Weinbreck, P; Denis, F; Martin, C

2008-06-01

We conducted a molecular epidemiology of Mycobacterium tuberculosis in Limousin, a French area with a low incidence of tuberculosis (4.8/100,000 inhabitants in 2005) to define the molecular diversity and the pattern of transmission. Two hundred and fifty-nine strains were isolated (each strain corresponds to one patient) from 1998 to 2006. Both spoligotyping and MIRU15 were chosen for our study because of their discriminatory power. Only 165 medical records were available: 99M/66F, mean age 56.4 years (14-94), 32.7% foreign-born patients, 16.9% homeless or living in shelters, 21.8% of immunocompromised patients (three HIV positive), 14.5% of alcohol addicts. Pulmonary manifestations were predominant (81.8%) with 45.1% of positive smears. Two strains among the 259 presented a multidrug resistance. Spoligotyping identified 136/259 spoligotypes (110 unique, 26 clusters composed of two to 36 isolates); within these 26 clusters, ST53 (n=36) and ST50 (n=19) were the most frequent. Three major families were observed as follow: T1 (30%), Haarlem (30%) and LAM (20%). MIRU15 identified 28/36 isolates in the ST53 group and 14/19 in the ST50 group. Eleven clusters (32 strains) with identical ST-MIRU15 were obtained with a proved case of recent transmission. Alcohol dependence, immunosuppression and pulmonary infections seem to be involved in transmission factors. M. tuberculosis strains isolated in Limousin are characterized by their high genetic diversity. The rate of recent transmission (8.1%) is low and therefore a reactivation process is predominant in this area.

2013 Inaugural Parade

NASA Image and Video Library

2013-01-21

The presidential limousine is seen traveling up Pennsylvania Avenue soon after President Barack Obama departed the White House for Capitol Hill and the swearing-in of Obama as the nation's 44th President, Monday, Jan. 21, 2013, in Washington. Photo Credit: (NASA/Carla Cioffi)

Developpement d'un montage simulant l'erosion par la pluie pour l'evaluation des revetements glaciophobes dans le domaine aerospatial

NASA Astrophysics Data System (ADS)

Tremblay, Sarah-Eve

Ce memoire presente le developpement d’un montage simulant l’erosion par la pluie afin d’effectuer l’evaluation de differents revetements glaciophobes dans le domaine aerospatial. Bien que plusieurs revetements presentent une bonne efficacite a reduire l’adherence et/ou l’accumulation de glace, ils ne repondent pas necessairement aux normes de resistance a l’erosion simulee par les gouttes de pluie les frappant a grande vitesse. Il n’existe qu’une installation en Amerique du Nord offrant un service d’essai qui evalue la resistance a l’erosion par la pluie suivant les normes aerospatiales. Etant l’unique institution pouvant faire la certification de peintures utilisees sur les avions en ce qui a trait a l’erosion par la pluie, ce service est donc difficile d’acces et couteux. Le laboratoire international des materiaux antigivre (LIMA) a developpe un essai plus rapide et moins couteux, facilitant ainsi le developpement de revetements glaciophobes devant resister a l’erosion par la pluie. Dans cette etude, le developpement du montage d’erosion par la pluie effectue au laboratoire des materiaux antigivre (LIMA) est presente. En particulier, des essais sur quatre (4) revetements dont la resistance a l’erosion est connue, et sur trois revetements industriels, ont ete effectues afin d’ajuster les differents parametres du montage comme la pression et la temperature de l’eau ainsi que la robustesse du montage. Ensuite, des essais de sensibilite et de reproductibilite des resultats ont egalement ete effectues pour fin de validation du montage et du protocole experimental. Pour ce faire, le montage de type jet d’eau developpe consiste principalement en une pompe a haute pression qui projette un jet d’eau continu passant par les orifices d’un disque tournant. Cette operation permet de generer une goutte de pluie simulee qui est projetee sur un echantillon de revetement statique. L’essai est base sur la norme standard ASTM (Liquid Impingement Erosion Testing, G73-82). La resistance a l’erosion du materiau est determinee a l’aide du nombre d’impacts subi par l’echantillon obtenu avant la production de dommages visibles. Donc, pour determiner le niveau d’erosion, quatre sites d’impacts doivent etre erodes sur cinq sur le meme rang pour le meme nombre d’impact. L’analyse des quatre revetements de resistance a l’erosion connus a ete completee par l’examen microscopique de chaque site d’impact et d’une photo. Le choix des quatre revetements de resistance a l’erosion connue, allant du plus resistant au moins resistant, a permis de verifier que le montage etait assez sensible pour evaluer les revetements souvent utilises dans le domaine aerospatial. De plus, l’evaluation des trois revetements industriels a permis, pour sa part, de confirmer les resultats obtenus precedemment. Finalement, pour evaluer la sensibilite et la reproductibilite des resultats, de deux a six repetitions pour chaque revetement a ete effectuees donnant des taux d’erosion allant de 100 a 100 000 impacts. L’intervalle des ecarts-types varie de ± 0% a ± 47% pour une moyenne de ± 17%. Le critere d’echec a ete determine a l’aide du nombre d’impacts avant l’apparition de dommage visible ainsi que de la repetabilite des resultats.

Analysis of modeling aircraft noise with the Nord2000 noise model

DOT National Transportation Integrated Search

2012-10-31

This report provides comparisons between AEDT/INM and the Nord 2000 Noise Models for the following parameters: ground type, simple terrain (downward slope, upward slope, hill), temperature and humidity, temperature gradients (positive and negative), ...

L’effet du yoga chez les patients atteints de cancer

PubMed Central

Côté, Andréanne; Daneault, Serge

2012-01-01

Résumé Objectif Déterminer si le yoga thérapeutique améliore la qualité de vie de patients atteints de cancer. Sources des données Recherche effectuée avec la base de données MEDLINE (1950–2010) en utilisant les mots-clés yoga, cancer et quality of life. Sélection des études Priorité accordée aux études cliniques randomisées contrôlées évaluant l’effet du yoga sur différents symptômes susceptibles de se présenter chez des patients atteints de cancer en Amérique du Nord. Synthèse Quatre études cliniques randomisées contrôlées ont d’abord été analysées, puis 2 études sans groupe-contrôle. Trois études réalisées en Inde et au Proche-Orient ont également apporté des éléments intéressants au plan méthodologique. Les interventions proposées comprenaient des séances de yoga d’une durée et d’une fréquence variables. Les paramètres mesurés variaient également d’une étude à l’autre. Plusieurs symptômes ont connu des améliorations significatives avec le yoga (meilleure qualité du sommeil, diminution des symptômes anxieux ou dépressifs, amélioration du bien-être spirituel, etc.). Il a aussi semblé que la qualité de vie, dans sa globalité ou dans certaines de ses composantes spécifiques, s’améliorait. Conclusion La variété des effets bénéfiques produits, l’absence d’effet secondaire et le rapport coût-bénéfice avantageux du yoga thérapeutique en fait une intervention intéressante à suggérer par les médecins de famille aux patients atteints de cancer. Certaines lacunes méthodologiques ont pu diminuer la puissance statistique des études présentées, à commencer par la taille restreinte des échantillons et par l’assiduité variable des patients soumis à l’intervention. Il est également possible que les échelles de mesure utilisées ne convenaient pas à ce type de situation et de clientèle pour qu’en soit dégagé un effet significatif. Toutefois, les commentaires favorables des participants recueillis au cours des études et leur degré d’appréciation et de bien-être donnent à penser qu’il faille poursuivre les recherches pour mieux en comprendre les mécanismes.

Results of baseline tests of the Lucas Limousine

NASA Technical Reports Server (NTRS)

Soltis, R. F.; Dustin, M. O.; Sargent, N. B.

1977-01-01

The Lucas Limousine, an electric vehicle, was tested to assess the state-of-the-art of electric vehicles. All tests were made without the regenerative braking system and were conducted at the gross vehicle weight of 7,700 pounds. Over a 30 mph stop and go driving cycle the vehicle went 48.4 miles. The vehicle was able to accelerate to 30 mph in about 15 seconds with a gradeability limit of 16.5 percent. As determined by coast down tests the road power and road energy consumption for the vehicle were 2.92 kilowatts and 0.146 kWh/mi, respectively, at 20 mph. At 40 mph the road power requirement was 11.12 kilowatts and the road energy requirement was 0.278 kWh/mi. The maximum energy economy measured 0.45 kilowatt hours per mile at 30 mph and increased to 0.76 kilowatt hours per mile at 50 mph. Over the 30 mph stop and go driving cycle the energy economy was 0.92 kilowatt hours per mile.

49 CFR 256.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... and others, and other public activities supported in whole or in part under Federal law. (g) Council...: Intercity bus, commuter rail, intra-city rail transit and bus transportation, airport limousine service and... Railroad Revitalization and Regulatory Reform Act of 1976, as amended, Public Law 94-210, 90 Stat. 125, 49...

Diversity and population-genetic properties of copy number variations and multicopy genes in cattle

USDA-ARS?s Scientific Manuscript database

The diversity and population-genetics of copy number variation (CNV) in domesticated animals are not well understood. In this study, we analyzed 75 genomes of major taurine and indicine cattle breeds (including Angus, Brahman, Gir, Holstein, Jersey, Limousin, Nelore, Romagnola), sequenced to 11-fold...

Feed intake and production efficiency of beef cows

USDA-ARS?s Scientific Manuscript database

The objective of this study was to determine the relationships between DMI and growth as heifers and cows and calves weaned, weight of calf weaned, and milk production. Cows born in 1999-2001and sired by industry AI bulls (Angus, Hereford, Simmental, Limousin, Charolais, Gelbvieh, and Red Angus) an...

Association of plasma ghrelin concentrations with feed intake in beef cattle

USDA-ARS?s Scientific Manuscript database

Active ghrelin is an acylated peptide produced in the gastrointestinal tract of animals that is thought to stimulate appetite. Cattle used in this experiment were sired by bulls representing five breeds in the U.S. including: Hereford, Angus, Limousin, Charolais, and Gelbvieh. Steers (n=128) and hei...

Chlorate poisoning in beef cattle

PubMed Central

Blakley, Barry R.; Fraser, Lorrie M.; Waldner, Cheryl

2007-01-01

A disease syndrome characterized by hemolysis, methemoglobinemia, methemoglobinuria, and death was observed in a herd of purebred Limousin beef cattle grazing on pasture in November in Alberta. Improper disposal of the nonselective herbicide, sodium chlorate, was identified as the causal agent. Highly variable blood methemoglobin levels reflected differences in herbicide consumption. PMID:17987970

Principales lignes structurales du Maroc nord-oriental : apport de la gravimétrie

NASA Astrophysics Data System (ADS)

Chennouf, Touria; Khattach, Driss; Milhi, Abdellah; Andrieux, Pierre; Keating, Pierre

2007-05-01

The present work is based on various filtered maps (horizontal derivative, upward continuation) and Euler deconvolution of the gravity data from northeastern Morocco. These results allow the delineation of many geological structures, such as faults, basins, or diapirs. Some of these structures are hidden totally or partially by the Mesozoic and Cenozoic cover. The results were used to make a structural map of the study area; this map confirms the existence of several faults, localised or inferred, from former geological studies. It complements information on some of them and outlines a great number of deep or near-surface faults that had remained unknown until the present time. The major features show two principal directions: N080°-085° and N055°-065°, with a predominance of the latter, and their depth can reach 4500 m. The N080°-085° directions correspond to the Kebdana, Sidi Bouhouria, Naima, and Guefait faults, and the N055°-065° directions correspond to a fault parallel to the Mediterranean coast and the Moulouya, Madagh, Angad, and Zekkara faults.

The Robinson and Weatherly uraniferous pyrobitumen deposits near Placerville, San Miguel County, Colorado

USGS Publications Warehouse

Wilmarth, V.R.; Vickers, R.C.

1953-01-01

Uranium deposits that contain uraniferous pyrobitumen of possible hydrothermal origin occur at the Weatherly and Robinson properties near Placerville, San Miguel County, Colo. These deposits were mined for copper, silver, and gold more than 50 years ago and were developed for uranium in 1950. The Robinson property, half a mile east of Placerville, consists of the White Spar, New Discovery Lode, and Barbara Jo claims. The rocks in this area are nearly horizontal sandstones, shales, limestones, and conglomerates of the Cutler formation of Permian age and the Dolores formation of Triassic and Jurassic (?) age. These rocks have been faulted extensively and intruded by a Tertiary (?) andesite porphyry dike. Uranium-bearing pyrobitumen associated with tennantite, tetrahedrite, galena, sphalerite, chalcopyrite, bornite, azurite, malachite, calcite, barite, and quartz occurs in a lenticular body as much as 40 feet long and 6 feet wide along a northwest-trending, steeply dipping normal fault. The uranium content of eleven samples from the uranium deposit ranges from 0.001 to 0.045 percent uranium and averages about 0.02 percent uranium. The Weatherly property, about a mile northwest of Placerville, consists of the Black King claims nos. 1, 4, and 5. The rocks in this area include the complexly faulted Cutler formation of Permian age and the Dolores formation of Triassic and Jurassic (?) age. Uranium-bearing pyrobitumen arid uranophane occur, along a northwest-trending, steeply dipping normal fault and in the sedimentary rocks on the hanging wall of the fault. Lens-shaped deposits in the fault zone are as much as 6 feet long and 2 feet wide and contain as much as 9 percent uranium; whereas channel samples across the fault zone contain from 0.001 to 0.014 percent uranium. Tetrahedrite, chalcopyrite, galena, sphalerite, fuchsite, malachite, azurite, erythrite, bornite, and molybdite in a gangue of pyrite, calcite, barite, and quartz are associated with the uraniferous material. In the sedimentary rocks on the hanging wall, uranium-bearing pyrobitumen occurs in replacement lenses as much as,8 inches wide and 6 feet long, and in nodules as much as 6 inches in diameter for approximately 100 feet away from the fault. Pyrite and calcite are closely associated with the uraniferous material in the sedimentary rocks. Samples from the replacement bodies contain from 0. 007 to 1.4 percent uranium.

Associations of a HinfI PCR-RFLP of POU1F1 gene with growth traits in Qinchuan cattle.

PubMed

Zhang, Chunlei; Liu, Bo; Chen, Hong; Lan, Xianyong; Lei, Chuzhao; Zhang, Zhiqing; Zhang, Runfeng

2009-01-01

The objectives of the present study were to estimate the allele and genotype frequencies of the POU1F1/HinfI polymorphisms in beef cattle belonging to four different genetic groups and to determine the effects of these polymorphisms on growth traits in cattle. The 451-bp PCR products of POU1F1 gene digested with HinfI exhibited three genotypes and two alleles, which were at Hardy-Weinberg equilibrium (P > 0.05). Genotype BB was the predominant genotype and B the predominant allele in the studied populations. There was significant difference between Limousin x Qinchuan and Qinchuan in the distribution of genotypes (P < 0.0001). The association of the polymorphism of the POU1F1 gene with growth traits among Qinchuan, Limousin x Qinchuan, Angus x Qinchuan and Germany Yellow x Qinchuan crosses was analyzed. Body weight and wither height of individuals with genotypes AB were higher (P < 0.05)than that of individuals with genotype BB in the Germany Yellow x Qinchua cross, but were not in the other three populations (P > 0.05).

The origin of increased salinity in the Cambrian-Vendian aquifer system on the Kopli Peninsula, northern Estonia

NASA Astrophysics Data System (ADS)

Karro, Enn; Marandi, Andres; Vaikmäe, Rein

Monitoring of the confined Cambrian-Vendian aquifer system utilised for industrial water supply at Kopli Peninsula in Tallinn over 24 years reveals remarkable changes in chemical composition of groundwater. A relatively fast 1.5 to 3.0-fold increase in TDS and in concentrations of major ions in ed groundwater is the consequence of heavy pumping. The main sources of dissolved load in Cambrian-Vendian groundwater are the leaching of host rock and the other geochemical processes that occur in the saturated zone. Underlying crystalline basement, which comprises saline groundwater in its upper weathered and fissured portion, and which is hydraulically connected with the overlying Cambrian-Vendian aquifer system, is the second important source of ions. The fractured basement and its clayey weathering crust host the Ca-Cl type groundwater, which is characterised by high TDS values (2-20 g/L). Intensive water ion accelerates the exchange of groundwaters and increases the area of influence of pumping. Chemical and isotopic studies of groundwater indicate an increasing contribution of old brackish water from the crystalline basement and rule out the potential implication of an intrusion of seawater into aquifer. L'origine de la salinité croissante dans le système aquifère du Cambrien-Vendien dans la péninsule de Kopli, nord de l'Estonie Le suivi à long terme du système aquifère captif du Cambrien-Vendien utilisé pour l'approvisionnement d'eaux industrielles dans la Péninsule de Kopli, nord de l'Estonie, révèle de remarquables changements dans la composition chimique des eaux souterraines. Une augmentation de facteur 1.5 à 3 de la TDS et des concentrations en ions majeurs dans l'eau souterraine est la conséquence de pompages intensifs. Les sources principales des charges dissoutes dans les eaux de l'aquifère du Cambrien-Vendien sont le lessivage des roches et d'autres phénomènes géochimiques ayant lieu dans la zone saturée. Le soubassement rocheux cristallin, qui renferme des eaux souterraines salines dans sa partie supérieure altérée et fissurée, et est hydrauliquement connecté avec l'aquifère supérieur du Cambrien-Vendien, est la deuxième importante source d'ions. Le soubassement fracturé et le matériel argileux de l'altération, renferme l'eau souterraine de type Ca-Cl, caractérisée par un haut TDS (2-20 g/l). A cause de la mobilisation intensive de l'eau les échanges d'eau souterraine est sont accélérés et la zone d'influence des pompages augmentent. Les études chimiques et isotopiques indiquent une contribution croissante du drainage des eaux du soubassement cristallin. L'intrusion d'eaux salées de la mer dans le système aquifère n'est pas un phénomène évident. El origen del incremento en salinidad en un sistema de acuíferos Cámbrico-Vendiano en la Península Kopli, norte de Estonie Monitoreo a largo plazo de un sistema de acuíferos confinados, de edad Cámbrico-Vendiano, que se utiliza como fuente de abastecimiento industrial en la Península Kopli, al norte de Estonie, revela cambios notables en la composición química del agua subterránea. Un incremento de 1.5 a 3 veces en TDS y en concentraciones de iones mayores en agua subterránea explotada ha sido ocasionado por bombeo fuerte. Las fuentes principales de carga disuelta en el agua subterránea Cámbrico-Vendiano son la lixiviación de la roca encajonante y los procesos geoquímicos que ocurren en la zona saturada. Basamento cristalino subyacente, que aloja agua subterránea salada en la parte superior intemperizada y fisurada, y está conectado hidráulicamente con el sistema acuífero Cámbrico-Vendiano sobreyacente, es la segunda fuente importante de iones. El basamento fracturado y su corteza de intemperismo arcillosa alojan agua subterránea de tipo Ca-Cl la cual se caracteriza por valores altos de TDS (2-20 g/l). Debido a extracción intensiva se ha acelerado el intercambio de agua subterránea y se ha incrementado el área de influencia del bombeo. Los estudios químicos e isotópicos de agua subterránea indican una contribución creciente por filtración derivada del basamento cristalino. Es evidente una intrusión de agua salada hacia el sistema de acuíferos con implicaciones subsecuentes para la calidad del agua.

Accuracies of genomically estimated breeding values from pure-breed and across-breed predictions in Australian beef cattle.

PubMed

Boerner, Vinzent; Johnston, David J; Tier, Bruce

2014-10-24

The major obstacles for the implementation of genomic selection in Australian beef cattle are the variety of breeds and in general, small numbers of genotyped and phenotyped individuals per breed. The Australian Beef Cooperative Research Center (Beef CRC) investigated these issues by deriving genomic prediction equations (PE) from a training set of animals that covers a range of breeds and crosses including Angus, Murray Grey, Shorthorn, Hereford, Brahman, Belmont Red, Santa Gertrudis and Tropical Composite. This paper presents accuracies of genomically estimated breeding values (GEBV) that were calculated from these PE in the commercial pure-breed beef cattle seed stock sector. PE derived by the Beef CRC from multi-breed and pure-breed training populations were applied to genotyped Angus, Limousin and Brahman sires and young animals, but with no pure-breed Limousin in the training population. The accuracy of the resulting GEBV was assessed by their genetic correlation to their phenotypic target trait in a bi-variate REML approach that models GEBV as trait observations. Accuracies of most GEBV for Angus and Brahman were between 0.1 and 0.4, with accuracies for abattoir carcass traits generally greater than for live animal body composition traits and reproduction traits. Estimated accuracies greater than 0.5 were only observed for Brahman abattoir carcass traits and for Angus carcass rib fat. Averaged across traits within breeds, accuracies of GEBV were highest when PE from the pooled across-breed training population were used. However, for the Angus and Brahman breeds the difference in accuracy from using pure-breed PE was small. For the Limousin breed no reasonable results could be achieved for any trait. Although accuracies were generally low compared to published accuracies estimated within breeds, they are in line with those derived in other multi-breed populations. Thus PE developed by the Beef CRC can contribute to the implementation of genomic selection in Australian beef cattle breeding.

Comparing the 2000 and 2005 factors affecting the selling price of feeder cattle sold at Arkansas livestock auctions.

PubMed

Troxel, T R; Barham, B L

2007-12-01

The objectives of the study were to determine how factors affecting the selling price of feeder calves changed from 2000 to 2005 and to examine the perception that discounts narrow or even disappear as calf supplies decrease and selling prices increase. Data from weekly Arkansas livestock auctions were collected from January 1 to December 31 in 2000 and 2005. Data included calf sex, breed type, color, muscle score, horn status, frame score, fill, condition, health, and BW. Mean selling prices for 2000 and 2005 were $92.91 +/- 15.05 and $118.32 +/- 15.13 (mean +/- SD; $/45.45 kg), respectively. Individual price observations were subtracted from the respective annual means and became the dependent variable. The selling prices for feeder calves sold in groups of 2 to 5 calves and in groups of >/= 6 calves were greater in 2005 than 2000 (P < 0.001). Steers received a greater premium ($6.48 +/- 0.09 vs. $6.02 +/- 0.08; mean +/- SE) and bull calves received greater discounts ($0.30 +/- 0.14 vs. $1.68 +/- 0.09) in 2005 than in 2000. Breeds types that increased in value from 2000 to 2005 were Angus x Hereford, Angus, Angus x Charolais, and Brahman (P < 0.001). Breed types that received a reduced selling price in 2005 compared with 2000 (P < 0.001) were one-fourth Brahman Cross, Charolais, Charolais x Limousin, Hereford x Limousin, Limousin, Limousin x one-fourth Brahman, Longhorn, Saler and Simmental. Yellow-white face, black-white face, black, and gray feeder calves received an increase in selling price from 2000 to 2005 (P < 0.001). Although fewer horned feeder calves were sold in 2005 (P < 0.01), they received greater discounts in 2005 than 2000 (-$2.86 +/- 0.16 and -$0.51 +/- 0.09; P < 0.001). In 2005, large-framed feeder calves did not receive the premium detected in 2000, but medium-framed feeder calves in 2005 received a greater selling price compared with 2000. Feeder calves with a muscle score of 1 received a greater premium in 2005 compared with 2000 ($2.58 +/- 0.06 and $0.02 +/- 0.09, respectively; P < 0.001). Feeder calves with a muscle score of 2 were discounted in both years, but the discount in 2005 was not as great as in 2000 (P < 0.001). Full and tanked feeder calves received greater discounts in 2005 than in 2000 (P < 0.001). Discounts for fleshy and fat feeder calves were greater in 2005 than in 2000. Most factors affecting the selling price of Arkansas feeder calves in 2000 affected the selling price in 2005. Although feeder calf supplies were smaller in 2005 than 2000, many discounts increased.

Caractérisation pétrologique et géochimique du magmatisme ubendien du secteur de Pepa-Lubumba, sur le plateau des Marungu (Nord-Est du Shaba, Zaire). Signification géodynamique dans l'évolution de la chaîne ubendienne

NASA Astrophysics Data System (ADS)

Kabengele, M.; Lubala, R. T.; Cabanis, B.

Volcanic and plutonic rocks of Pepa-Lubumba area in the Marungu plateau (Zaire) are mainly represented by intermediate and acid members which contain low abundances in TiO 2 (0.3 - 1.3 wt%). All these rocks exhibit a high-K calc-alkaline affinity and belong to a calc-alkaline continental-margin series. The large proportion of frequently zoned (normal and reverse zoning) plagioclase, the presence of hydrous phases (tschermakitic and Mg-hornblende, Mg-biotite), the early crystallization of FeTi oxides indicate crystallization under high water pressure conditions, consistent with a calc-alkaline affinity. High abundances in K, Rb, Sr and Ba; lack of correlation between Rb and Ba, low values of Rb/Zr (0.5 - 0.9) in granitoids, high contents of LREE and HFSE (Th/Ta : 6 - 14), are characteristic of "Andinotype" magmas. A whole rock RbSr isochron gives an emplacement age for granitoids of 1861 ± 28 Ma (MSWD : 0.82), Sr initial ratio of 0.7026 and epsilon Sr i of + 4.7. PbPb isotopes systematics for the same rocks give the following ratio ranges : 206Pb/ 204Pb : 17.26 - 20.10; 207Pb/ 204Pb 15.52 - 15.85, 208Pb/ 204Pb : 37.2 - 41.80. The low Sr initial ratio indicates an upper mantle source; while the PBPb isotope ratios suggest that the mantellic liquids have been contaminated by crustal material en route to the upper levels. In the regional geologic context, this magmatism forms a part of an important plutovolcanic Ubendian (Early Proterozoic) complex which crops out in Western Tanzania, North-Eastern Zambia and Marungu plateau (Zaire) and contains two magmatic cycles which define a spatial and temporal zonation suggesting a geodynamic evolution model for the Ubendian belt comprising subduction-obduction-collision processes. This latter episode has been relayed by a relaxation phase marked by emplacement of a third tholeiitic basic plutonic cycle.

L'Anti-Atlas occidental du Maroc: étude sédimentologique et reconstitutions paléogéographiques au Cambrien inférieur

NASA Astrophysics Data System (ADS)

Benssaou, M.; Hamoumi, N.

2001-04-01

L'étude lithostratigraphique en sédimentologique des formations du Cambrien inférieur de l'Anti-Atlas occidental (Maroc) a permis de mettre en évidence la diversité extrême des faciès allant des faciès continentaux jusqu'au faciès franchement marins. La répartition verticale de ces faciès ainsi que leurs associations ont permis de (i) proposer un nouveau découpage de la succession en formations lithostratigraphiques, (ii) reconstituer les milieux de dépôt (système fluviatile, lacs, fan-deltas, milieu littoral, plate-forme dominée par des constructions stromatolitiques et récifales et plate-forme dominée par les tempêtes) et (iii) établir des modèles paléogéographiques retraçant les différentes étapes d'évolution de ce bassin qui fait partie de la plate-forme nord-gondwanienne au Cambrien inférieur. Lithostratigraphical and sedimentological studies of the Early Cambrian formations in the western Anti-Atlas (Morocco) evidence their large diversity of facies ranging from continental to clearly marine. Vertical distribution and associations of facies afford opportunities to (i) suggest a new classification of the sedimentary sequence in terms of lithostratigraphic formations, (ii) restore the depositional environments (fluvial system, lake, delta fan, coast, stromatolite and reef-dominated platform, tempest-dominated platform), and (iii) establish palæogeographic models displaying the different evolutionary stages of this basin that constituted a part of the Lower Cambrian north-Gondwanian platform.

Regional Development and Vocational Training. The Problems of Evaluation. Colloquium (Limoges, France, June 18-19, 1990).

ERIC Educational Resources Information Center

Pierret, M.

1990-01-01

This paper summarizes the proceedings of a conference held to discuss evaluation in vocational education. The agenda included welcome speeches and the introductory address by Robert Savy, President of the Regional Council of Limousin (France); an opening session with statements from representatives of the Commission of the European Communities…

New geological model of the Lagoa Real uraniferous albitites from Bahia (Brazil)

NASA Astrophysics Data System (ADS)

de Oliveira Chaves, Alexandre

2013-09-01

New evidence supported by petrography (including mineral chemistry), lithogeochemistry, U-Pb geochronology by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS), and physicochemical study of fluid and melt inclusions by LA-ICP-MS and microthermometry, point to an orogenic setting of Lagoa Real (Bahia-Brazil) involving uraniferous mineralization. Unlike the previous models in which uraniferous albitites represent Na-metasomatised 1.75 Ga anorogenic granitic rocks, it is understood here that they correspond to metamorphosed sodium-rich and quartz-free 1.9 Ga late-orogenic syenitic rocks (Na-metasyenites). These syenitic rocks are rich not only in albite, but also in U-rich titanite (source of uranium). The interpretation of geochemical data points to a petrogenetic connection between alkali-diorite (local amphibolite protolith) and sodic syenite by fractional crystallization through a transalkaline series. This magmatic differentiation occurred either before or during shear processes, which in turn led to albitite and amphibolite formation. The metamorphic reactions, which include intense recrystallization of magmatic minerals, led uraninite to precipitate at 1.87 Ga under Oxidation/Reduction control. A second population of uraninites was also generated by the reactivation of shear zones during the 0.6 Ga Brasiliano Orogeny. The geotectonic implications include the importance of the Orosirian event in the Paramirim Block during paleoproterozoic Săo Francisco Craton edification and the influence of the Brasiliano event in the Paramirim Block during the West-Gondwana assembly processes. The regional microcline-gneiss, whose protolith is a 2.0 Ga syn-collisional potassic granite, represents the albitite host rock. The microcilne-gneiss has no petrogenetic association to the syenite (albitite protolith) in magmatic evolutionary terms.

Mineral resource potential map of the Great Rift Instant Study Area, Blaine, Butte, Minidoka, and Power counties, Idaho

USGS Publications Warehouse

Ridenour, James; Stotelmeyer, Ronald B.; Kuntz, Mel A.; Mabey, Don R.; Champion, Duane E.; Lefebvre, Richard H.; Stanley, W.D.

1983-01-01

Locating speculative resources (uraniferous sediment, auriferous gravel, and geothermal reservoirs) and hypothetical resources (oil and gas) that may underlie the geologically young lava flows of the study area would require extensive geophysical exploration and drilling.

Water-gas dynamics and coastal land subsidence over Chioggia Mare field, northern Adriatic Sea

NASA Astrophysics Data System (ADS)

Teatini, Pietro; Baú, Domenico; Gambolati, Giuseppe

2000-09-01

A major development programme comprising 15 gas fields of the northern Adriatic Sea has recently been submitted to the Ministry of the Environment, VIA Committee for the assessment of the environmental impact, by ENI-Agip, the Italian national oil company. One of the largest reservoirs is Chioggia Mare, located about 10 km offshore of the Venetian littoral, with a burial depth of 1000-1400 m. The planned gas production from this field is expected to impact the shoreline stability with a potential threat to the city of Venice, 25 km northwest of the center of Chioggia Mare. To evaluate the risk of anthropogenic land subsidence due to gas withdrawal, a numerical model was developed that predicts the compaction of both the gas-bearing formations and the lateral/bottom aquifer (water drive) during a 13-year producing and a 12-year post-production period, and the transference of the deep compaction to the ground surface. To address the uncertainty of a few important hydromechanical parameters, several scenarios are simulated and the most pessimistic predictions obtained. The modeling results show that at most 1 cm of land subsidence over 25 years may be expected at the city of Chioggia, whereas Venice is not subject to settlement. If aquifer drawdown is mediated by water injection, land subsidence is arrested 5 km offshore, with the Chioggia littoral zone experiencing a rebound of 0.6-0.7 cm. Résumé. Un important programme de développement portant sur 15 gisements de gaz du nord de l'Adriatique a été récemment soumis au Comité VIA pour l'évaluation de l'impact sur l'environnement du Ministère de l'Environnement, par la société ENI-Agip, la compagnie nationale pétrolière italienne. L'un des plus importants réservoirs est celui de Chioggia Mare, situé à environ 10 km au large du littoral vénitien, à une profondeur de 1000 à 1400 m. La production de gaz prévue pour ce gisement laisse envisager un impact sur la stabilité du trait de côte, avec une menace potentielle pour la ville de Venise, à 25 km au nord-ouest du centre de Chioggia Mare. Afin d'évaluer le risque de subsidence du sol provoquée par les prélèvements de gaz, un modèle numérique a été développé pour prévoir la compaction des formations réservoirs de gaz en même temps que celle de l'aquifère latéral et sous-jacent, par effet de drainance, sur une période de 13 ans de production, suivie de 12 ans, et pour prévoir le transfert de la compaction profonde jusqu'à la surface du sol. Afin de prendre en compte l'incertitude sur un petit nombre de paramètres hydromécaniques importants, plusieurs scénarios ont été simulés et les prévisions les plus pessimistes ont été obtenues. Les résultats de la modélisation montrent qu'on doit s'attendre, au cours des 25 ans, au plus à une subsidence du sol de 1 cm à Chioggia, tandis que Venise ne subira aucun effet. Si la baisse de l'aquifère est compensée par une injection d'eau, la subsidence du sol s'arrêtera à 5 km au large et la zone côtière de Chioggia subira un effet de 0,6 à 0,7 cm. Resumen. Recientemente, la compañía nacional italiana del petróleo, ENI-Agip, ha enviado al Ministerio de Medio Ambiente de Italia (Comité VIA) un gran programa de desarrollo de 15 campos de gas en el norte del Mar Adriático para la evaluación de su impacto medioambiental. Una de las reservas principales de gas se halla en el mar de Chioggia, a unos 10 km mar adentro de la costa veneciana, a una profundidad de entre 1.000 y 1.400 m. Se espera que la producción en este campo produzca un impacto en la estabilidad de la línea de costa, y que suponga una amenaza potencial para la ciudad de Venecia, situada a 25 km al noroeste de la explotación. Se desarrolló un modelo numérico para evaluar el riesgo de subsidencia debido a la extracción de gas a lo largo de los 13 años de producción y del período post-productivo de 12 años. Sus predicciones indican que se causará la compactación tanto de la formación que contiene el gas como del acuífero inferior y lateral. Además, esta compactación en profundidad tendrá un efecto en superficie. Con el objeto de estudiar la incertidumbre de unos pocos parámetros hidromecánicos fundamentales, se simularon diversos escenarios y se obtuvieron las predicciones más pesimistas. Los resultados numéricos muestran que, como máximo, se puede esperar una subsidencia de 1 cm en la ciudad de Chioggia al cabo de 25 años, mientras que no afectará a la ciudad de Venecia. Si se contrarresta el descenso de los niveles mediante inyecció de agua, se podrá limitar la subsidencia a un radio de 5 km mar adentro y propiciar un aumento de 0,6 a 0,7 cm en la costa de Chioggia.

The aqueous geochemistry of uranium in a drainage containing uraniferous organic-rich sediments, Lake Tahoe area, Nevada, USA

USGS Publications Warehouse

Zielinski, R.A.; Otton, J.K.; Wanty, R.B.; Pierson, C.T.

1988-01-01

Anomalously uraniferous waters occur in a small (4.2 km2) drainage in the west-central Carson Range, Nevada, on the eastern side of Lake Tahoe. The waters transport uranium from local U-rich soils and bedrock to organic-rich valley-fill sediments where it is concentrated, but weakly bound. The dissolved U and the U that is potentially available from coexisting sediments pose a threat to the quality of drinking water that is taken from the drainage. The U concentration in samples of 6 stream, 11 spring and 7 near-surface waters ranged from 0.1 V). Possible precipitation of U(IV) minerals is predicted under the more reducing conditions that are particularly likely in near-surface waters, but the inhibitory effects of sluggish kinetics or organic complexing are not considered. These combined results suggest that a process such as adsorption or ion exchange, rather than mineral saturation, is the most probable mechanism for uranium fixation in the sediments. -Authors

Lithostratigraphie, sédimentologie et évolution de deux bassins molassiques intramontagneux de la chaine Pan-Africaine: la Série pourprée de l'Ahnet, Nord-Ouest du Hoggar, Algérie

NASA Astrophysics Data System (ADS)

Ait-Kaci Ahmed, Ali; Moussine-Pouchkine, Alexis

The study of two of the intermontane molassic basins of the 'Série pourprée de l'Ahnet' shows that they developed independently both in time and space. The characteristics of their thick sedimentary infillings are quite different. The Ouallen basin is filled by essentially fine-grained sediments which were deposited in continental then marine or lacustrine environments; these sediments thicen from east to west. The In Semmen basin is characterised by coarser sediments which were deposited from south to north, in alluvial fan, fluvial, deltaic and slope environments. This basin is also characterised by an episode of carbonate sedimentation leading to the formation of a remarkable thin layer of carbonate, covering the entire sedimentary area, and perhaps related to a volcanic rhyolitic event. The history of the two basins is also marked by obvious tectonic events simultaneous with the sedimentation and related to the recurrent faulting of major Pan-African faults. These led to the formation of very coarse fanglomerates located near the fault scarps, and are probably responsible for the shape and the evolution of the basins.

Une plate-forme en distension, témoin de phases pré-accrétion téthysienne en Afrique du Nord pendant le Toarcien Aalénien (synclinal Iguer Awragh Afennourir, Moyen Atlas occidental, Maroc)A pre-accretional extensional platform of the North African Tethys during the Toarcian Aalenian (Iguer Awragh Afennourir syncline, western Middle Atlas, Morocco)

NASA Astrophysics Data System (ADS)

El Hammichi, Fatima; Elmi, Serge; Faure-Muret, Anne; Benshilil, Khadija

2002-10-01

A stratigraphic study and mapping allow defining the particular features of this area of the southwestern Middle Atlas (Morocco) during the Toarcian and the Aalenian. Numerous spectacular variations in thickness and facies are documented by the discovery of coralline build-ups dated to the Late Toarcian. They occur along the palaeostructures. Development of the structures occurred in several stages: (1) initial differentiation during the Early and Middle Toarcian; (2) homogenisation during the Late Toarcian, after the construction of the reefs. The Aalenian history is similar: differentiation (Early Aalenian)-homogenisation (Middle to Late Aalenian). Two palaeostructural trends are evident: SW-NE and transverse SSW-NNE to south-north. These caused separation of several subbasins, which alternatively deepened and shallowed, probably due to the tilting of several blocks to the southwest. To cite this article: F. El Hammichi et al., C. R. Geoscience 334 (2002) 1003-1010.

Superposition de la tectonique éburnéenne et panafricaine dans les granitoïdes de la bordure nord du craton ouest africain, boutonniére de Zenaga, Anti-Atlas central, Maroc(Pan-african overprint on Eburnian granitoids at the northern boundary of the West African Craton, Zenaga Inlier, central Anti-Atlas, Morocco)

NASA Astrophysics Data System (ADS)

Ennih, N.; Laduron, D.; Greiling, R. O.; Errami, E.; de Wall, H.; Boutaleb, M.

2001-05-01

The Zenaga Inlier shows a comprehensive record of the Eburnian and Pan-African Orogenies. The Eburnian is characterised by high-temperature regional metamorphism and complex magmatism. The early (Azguemerzi) granodiorite has an isotopic mantle signature and was emplaced diapirically during the Eburnian Orogeny causing local thermal metamorphism. The foliation observed in this granitoid is a result of the interference between its primary syn-emplacement foliation and the regional foliation under amphibolite-facies conditions. The northern part of Zenaga has been intruded by the leucocratic granites of Tazenakht. These granites are cut by mylonites and phyllonites, corresponding to the Pan-African shear zones and accompanied with sub-greenschist-facies metamorphism during the Pan-African Orogeny. The deformation was the result of a regional sinistral transpressive event. This study in the northern part of the West African Craton shows the superposition of the Pan-African on the Eburnian Orogeny and the presence of a major fault in the Anti-Atlas.

High-density SNP Scan of Production and Product Quality Traits in Beef Cattle

USDA-ARS?s Scientific Manuscript database

Genotypes from the BovineSNP50 BeadChip (50K) were obtained on animals derived from 150 AI sires from seven breeds (22 sires per breed; Angus, Charolais, Gelbvieh, Hereford, Limousin, Red Angus, and Simmental) as either progeny (F1; 590 steers) or grandprogeny (F1 x F1 = F1**2; 1,306 steers and 707 ...

Crude glycerine inclusion in Limousin bull diets: animal performance, carcass characteristics and meat quality.

PubMed

Egea, M; Linares, M B; Garrido, M D; Villodre, C; Madrid, J; Orengo, J; Martínez, S; Hernández, F

2014-12-01

Three hundred and six Limousin young bulls (7±1months of age, initial body weight 273±43kg) were used to evaluate the effect of crude glycerine supplementation on animal performance, carcass characteristics and meat quality. Animals were assigned to three different diets: Control (0% of crude glycerine), G2 and G4 (2 and 4% of crude glycerine, respectively). The diets were administrated ad libitum for 240days (final body weight 644±24kg). Average daily weight gain, average daily feed intake, the gain:feed ratio, ultrasound measures in vivo, carcass characteristics, pH, water holding capacity, drip losses, and cooking losses were not affected (P>0.05) by diets. Diet decreased C16:0 (P<0.01) and C16:1 (P<0.05) contents in meat. The G4 meat showed lower C12:0, C14:0, C17:0, C18:0, C18:1, C18:2, C18:3, c9,t11-c18:2, C20:0 and C20:4 levels (P<0.05) than control. Glycerine increased desirable fatty acid percentages (P<0.05) in intramuscular fat. Copyright © 2014 Elsevier Ltd. All rights reserved.

Fine mapping of quantitative trait loci underlying sensory meat quality traits in three French beef cattle breeds.

PubMed

Allais, S; Levéziel, H; Hocquette, J F; Rousset, S; Denoyelle, C; Journaux, L; Renand, G

2014-10-01

Improving the traits that underlie meat quality is a major challenge in the beef industry. The objective of this paper was to detect QTL linked to sensory meat quality traits in 3 French beef cattle breeds. We genotyped 1,059, 1,219, and 947 young bulls and their sires belonging to the Charolais, Limousin, and Blonde d'Aquitaine breeds, respectively, using the Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA). After estimating relevant genetic parameters using VCE software, we performed a linkage disequilibrium and linkage analysis on 4 meat traits: intramuscular fat content, muscle lightness, shear force, and tenderness score. Heritability coefficients largely ranged between 0.10 and 0.24; however, they reached a maximum of 0.44 and 0.50 for intramuscular fat content and tenderness score, respectively, in the Charolais breed. The 2 meat texture traits, shear force and tenderness score, were strongly genetically correlated (-0.91 in the Charolais and Limousin breed and -0.86 in the Blonde d'Aquitaine breed), indicating that they are 2 different measures of approximately the same trait. The genetic correlation between tenderness and intramuscular fat content differed across breeds. Using a significance threshold of 5 × 10(-4) for QTL detection, we found more than 200 significant positions across the 29 autosomal chromosomes for the 4 traits in the Charolais and Blonde d'Aquitaine breeds; in contrast, there were only 78 significant positions in the Limousin breed. Few QTL were common across breeds. We detected QTL for intramuscular fat content located near the myostatin gene in the Charolais and Blonde d'Aquitaine breeds. No mutation in this gene has been reported for the Blonde d'Aquitaine breed; therefore, it suggests that an unknown mutation could be segregating in this breed. We confirmed that, in certain breeds, markers in the calpastatin and calpain 1 gene regions affect tenderness. We also found new QTL as several QTL on chromosome 3 that are significantly associated with meat tenderness in the Blonde d'Aquitaine breed. Overall, these results greatly contribute to the goal of building a panel of markers that can be used to select animals of high meat quality.

Etude energetique et modelisation d'un Systeme Hybride Eolien-Diesel avec stockage d'Air Comprime (SHEDAC)

NASA Astrophysics Data System (ADS)

Martinez, Nicolas

Actuellement le Canada et plus specialement le Quebec, comptent une multitude de sites isoles dont !'electrification est assuree essentiellement par des generatrices diesel a cause, principalement, de l'eloignement du reseau central de disuibution electrique. Bien que consideree comme une source fiable et continue, 1 'utilisation des generatrices diesel devient de plus en plus problematique d'un point de vue energetique, economique et environnemental. Dans le but d'y resoudre et de proposer une methode d'approvisionnement plus performante, mains onereuse et plus respectueuse de l'environnement, l'usage des energies renouvelables est devenu indispensable. Differents travaux ont alors demontre que le couplage de ces energies avec des generauices diesel, formant des systemes hybrides, semble etre une des meilleures solutions. Parmi elles, le systeme hybride eolien-diesel avec stockage par air comprime (SHEDAC) se presente comme une configuration optimale pour 1 'electrification des sites isoles. En effet, differentes etudes ont permis de mettre en avant l'efficacite du stockage par air comprime, par rapport a d'autres technologies de stockage, en complement d'un systeme hybride eolien-diesel. Plus precisement, ce systeme se compose de sous-systemes qui sont: des eoliennes, des generatrices diesel et une chaine de compression et de stockage d'air comprime qui est ensuite utilisee pour suralimenter les generatrices. Ce processus permet ainsi de reduire Ia consommation en carburant tout en agrandissant la part d'energie renouvelable dans Ia production electrique. A ce jour, divers travaux de recherche ont pennis de demontrer I' efficacite d 'un tel systeme et de presenter une variete de configurations possibles. A travers ce memoire, un logiciel de dimensionnement energetique y est elabore dans le but d'unifom1iser !'approche energetique de cette technologie. Cet outil se veut etre une innovation dans le domaine puisqu'il est actuellement impossible de dimensionner un SHEDAC avec les outils existants. Un etat de l'art specifique associe a une validation des resultats a ete realise dans le but de proposer un logiciel fiable et performant. Dans une logique visant !'implantation d'un SHEDAC sur un site isole du Nord-du-Quebec, le logiciel developpe a ete, ensuite, utilise pour realiser une etude energetique permettant d' en degager la solution optimale a mettre en place. Enfin, a l' aide des outils et des resultats obtenus precedemment, !'elaboration de nouvelles strategies d'operation est presentee dans le but de demontrer comment le systeme pourrait etre optimise afm de repondre a differentes contraintes techniques. Le contenu de ce memoire est presente sous forme de trois articles originaux, soumis a des joumaux scientifiques avec cornite de lecture, et d'un chapitre specifique presentant les nouvelles strategies d 'operation. Ils relatent des travaux decrits dans le paragraphe precedent et permettent d'en deduire un usage concluant et pertinent du SHEDAC dans un site isole nordique.

Quaternary Aquifer of the North China Plain-assessing and achieving groundwater resource sustainability

NASA Astrophysics Data System (ADS)

Foster, Stephen; Garduno, Hector; Evans, Richard; Olson, Doug; Tian, Yuan; Zhang, Weizhen; Han, Zaisheng

The Quaternary Aquifer of the North China Plain is one of the world's largest aquifer systems and supports an enormous exploitation of groundwater, which has reaped large socio-economic benefits in terms of grain production, farming employment and rural poverty alleviation, together with urban and industrial water-supply provision. Both population and economic activity have grown markedly in the past 25 years. Much of this has been heavily dependent upon groundwater resource development, which has encountered increasing difficulties in recent years primarily as a result of aquifer depletion and related phenomena. This paper focuses upon the hydrogeologic and socio-economic diagnosis of these groundwater resource issues, and identifies strategies to improve groundwater resource sustainability. L'aquifère Quaternaire de la Plaine du Nord de la Chine est l'un des plus grands systèmes aquifères du monde; il permet une exploitation énorme d'eau souterraine, qui a permis des très importants bénéfices socio-économiques en terme de production de céréales, d'emplois ruraux et de réduction de la pauvreté rurale, en même temps que l'approvisionnement en eau potable et pour l'industrie. La population comme l'activité économique ont remarquablement augmenté au cours de ces 25 dernières années. Elles ont été sous la forte dépendance du développement de la ressource en eau souterraine, qui a rencontré des difficultés croissantes ces dernières années, du fait du rabattement de l'aquifère et des phénomènes associés. Cet article est consacré aux diagnostiques hydrogéologique et socio-économique des retombées de cette ressource en eau souterraine; il identifie les stratégies pour améliorer la pérennité des ressources en eau souterraine. El acuífero cuaternario de la Llanura Septentrional de China es uno de los mayores sistemas acuíferos del mundo y soporta una enorme explotación de su agua subterránea, las cuales han originado grandes beneficios socioeconómicos en términos de producción de grano, empleo en agricultura y mitigación de la pobreza rural, además de proveer agua para abastecimiento urbano e industria. Tanto la población como la actividad económica han crecido mucho en los últimos 25 años con una gran dependencia de las aguas subterráneas, que ha encontrado dificultades recientes por la explotación intensiva del acuífero y fenómenos relacionados. Este artículo se centra en la diagnosis hidrogeológica y socioeconómica de los problemas relacionados con las aguas subterráneas e identifica estrategias para mejorar la sustentabilidad de este recurco.

Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo)

PubMed Central

Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadóttir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper

2017-01-01

Purpose To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. Participants Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964–2014 (with various start and end years in different countries). Data regarding cancer, other diseases and mortality were retrieved from the nationwide registries for cancer, patients and causes of death, respectively. Findings to date The NordASCo includes 945 153 individuals with a diagnosis of GORD. Of these, 48 433 (5.1%) have undergone primary antireflux surgery. Median age at primary antireflux surgery ranged from 47 to 52 years in the different countries. The coding practices of GORD seem to have differed between the Nordic countries. Future plans The NordASCo will initially be used to analyse the risk of developing known or potential GORD-related cancers, that is, tumours of the oesophagus, stomach, larynx, pharynx and lung, and to evaluate the mortality in the short-term and long-term perspectives. Additionally, the cohort will be used to evaluate the risk of non-malignant respiratory conditions that might be caused by aspiration of gastric contents. PMID:28600380

Prevalence and associated factors of DSM-V insomnia in Norway: the Nord-Trøndelag Health Study (HUNT 3).

PubMed

Uhlig, Benjamin Langsæter; Sand, Trond; Odegård, Siv Steinsmo; Hagen, Knut

2014-06-01

Many studies have assessed the prevalence of insomnia, but the influence of non-participants has largely been ignored. The objective of the present study was to estimate the prevalence and associated factors of insomnia in a large adult population using DSM-V (diagnostic and statistical manual of mental disorders, 5th ed.) criteria, also taking non-participants into account. This cross-sectional study used data from a questionnaire in The Nord-Trøndelag Health Study (HUNT 3) performed in 2006-2008, and a subsequent non-participant study. The total adult population (n=93,860 aged > or =20 years) of Nord-Trøndelag County, Norway, was invited. Of these, 40,535 responded to the insomnia questionnaire. Among 42,024 eligible non-participants, 6918 (17%) responded to two insomnia questions. Insomnia was diagnosed by applying modified DSM-V criteria. The age-adjusted insomnia prevalence was estimated using the age distribution of all adult inhabitants of Nord-Trøndelag. Supplementary prevalence data were estimated by extrapolating data from the non-participant study. Additionally, the association between insomnia and self-reported health was estimated, adjusting for known confounders. The total age-adjusted prevalence of insomnia was 7.1% (95% confidence interval [CI], 6.9-7.4) (8.6% for women, 5.5% for men). Adjusting for non-participants, the prevalence estimate changed to 7.9% (95% CI, 7.3-8.6) (9.4% for women, 6.4% for men). Insomnia was more than eight times more likely (OR, 8.3; 95% CI, 6.2-11.1) among individuals with very poor versus very good self-reported health, adjusting for age, gender, employment status, chronic musculoskeletal complaints, anxiety and depression. The adjusted insomnia prevalence estimate in Nord-Trøndelag was 7.9%. Insomnia was strongly associated with poor self-reported health. Copyright © 2014 Elsevier B.V. All rights reserved.

U-Pb ages of uraniferous opals and implications for the history of beryllium, fluorine, and uranium mineralization at Spor Mountain, Utah

USGS Publications Warehouse

Ludwig, K. R.; Lindsey, D.A.; Zielinski, R.A.; Simmons, K.R.

1980-01-01

The U-Pb isotope systematics of uraniferous opals from Spor Mountain, Utah, were investigated to determine the suitability of such material for geochronologic purposes, and to estimate the timing of uranium and associated beryllium and fluorine mineralization. The results indicate that uraniferous opals can approximate a closed system for uranium and uranium daughters, so that dating samples as young as ???1 m.y. should be possible. In addition, the expected lack of initial 230Th and 231Pa in opals permits valuable information on the initial 234U/238U to be obtained on suitable samples of ???10 m.y. age. The oldest 207Pb/235U apparent age observed, 20.8 ?? 1 m.y., was that of the opal-fluorite core of a nodule from a beryllium deposit in the Spor Mountain Formation. This age is indistinguishable from that of fission-track and K-Ar ages from the host rhyolite, and links the mineralization to the first episode of alkali rhyolite magmatism and related hydrothermal activity at Spor Mountain. Successively younger ages of 13 m.y. and 8-9 m.y. on concentric outer zones of the same nodule indicate that opal formed either episodically or continuously for over 10 m.y. Several samples of both fracture-filling and massive-nodule opal associated with beryllium deposits gave 207Pb/235U apparent ages of 13-16 m.y., which may reflect a restricted period of mineralization or perhaps an averaging of 21- and <13-m.y. periods of opal growth. Several samples of fracture-filling opal in volcanic rocks as young as 6 m.y. gave 207Pb/235U ages of 3.4-4.8 m.y. These ages may reflect hot-spring activity after the last major eruption of alkali rhyolite. ?? 1980.

West Europe Report, No. 2153

DTIC Science & Technology

1983-06-06

SEMAINE DE L’ENERGIE, 22 Mar 83) ...... ............. 10 Geothermal Energy Extracted From 5,000 Meters Below Surface ( Jean -Pierre Reillac; LES ECHOS...Unions Decry Lack of Anti-Unemployment Measures in New Plan ( Jean -Pierre Dumont; LE MONDE, 3-4 Apr 83) 34 GREECE Economic, Technical Cooperation...GEOTHERMAL ENERGY EXTRACTED FROM 5,000 METERS BELOW SURFACE Paris LES ECHOS in French 11 Apr 83 p 12 [Article by Jean -Pierre Reillac: "Limousin

Genetic Variation in FABP4 and Evaluation of Its Effects on Beef Cattle Fat Content.

PubMed

Goszczynski, Daniel E; Papaleo-Mazzucco, Juliana; Ripoli, María V; Villarreal, Edgardo L; Rogberg-Muñoz, Andrés; Mezzadra, Carlos A; Melucci, Lilia M; Giovambattista, Guillermo

2017-07-03

FABP4 is a protein primarily expressed in adipocytes and macrophages that plays a key role in fatty acid trafficking and lipid hydrolysis. FABP4 gene polymorphisms have been associated with meat quality traits in cattle, mostly in Asian breeds under feedlot conditions. The objectives of this work were to characterize FABP4 genetic variation in several worldwide cattle breeds and evaluate possible genotype effects on fat content in a pasture-fed crossbred (Angus-Hereford-Limousin) population. We re-sequenced 43 unrelated animals from nine cattle breeds (Angus, Brahman, Creole, Hereford, Holstein, Limousin, Nelore, Shorthorn, and Wagyu) and obtained 22 single nucleotide polymorphisms (SNPs) over 3,164 bp, including four novel polymorphisms. Haplotypes and linkage disequilibrium analyses showed a high variability. Five SNPs were selected to perform validation and association studies in our crossbred population. Four SNPs showed well-balanced allele frequencies (minor frequency > 0.159), and three showed no significant deviations from Hardy-Weinberg proportions. SNPs showed significant effects on backfat thickness and fatty acid composition (P < 0.05). The protein structure of one of the missense SNPs was analyzed to elucidate its possible effect on fat content in our studied population. Our results revealed a possible blockage of the fatty acid binding site by the missense mutation.

Area Handbook Series. Syria, A Country Study

DTIC Science & Technology

1987-04-01

of its lending wats in kind-primarily seeds, pesticides , and fertilizers at subsi- dlizeci prices. Although the hank appeared effective, there was...In one such rally, enthusiastic crowds carried his limousine through the streets of Damascus. Assad’s twenty-six-year-old son, Basil , who had previ...Assad, Basil al, 212 Druzes. 36, 37: economic strateg, 109: Assad, Fawwaz al, 205 and education, 1(11, 1(3, 2(14: factional Assad, Haliz al, xix, xxi

Profil épidémiologique des fibromes utérins dans la région de Sidi Bel Abbes, Algérie

PubMed Central

Chalal, Nourelhouda; Demmouche, Abbassia

2013-01-01

Introduction Les léiomyomes ou fibromyomes plus communément dénommés fibromes, sont les tumeurs les plus répandues du tractus génital féminin. Ils affectent 20 à 25% des femmes en activité génitale. Notre étude vise à élucider la réalité de ce type de pathologie dans la région de sidi bel Abbes, nord-ouest d'Algérie. Méthodes A travers une étude rétrospective allant du 1er janvier 2008 au 1 mai 2011 portant sur les patientes opérées pour fibrome au sein de la maternité de Sidi Bel Abbes, nous avons relevé les particularités épidémiologiques et cliniques de cette pathologie. Résultats Au total 323 cas de fibromes ont été recensés. La tranche d'âge la plus touchée varie de 40 à 44 ans dans une fourchette d'âge comprise entre 20 et 74 ans. 37.83% des patientes étaient nullipares. Une prédominance des patientes dont l'âge de la ménarche est précoce, a été retenue (60.3%). 3% des femmes ont présenté un terrain familial prédisposant. La symptomatologie était dominée par les hémorragies génitales (35%). La majorité des patientes (51.70%) présentaient un utérus polymyomateux dont la localisation des fibromes était principalement corporéale (96%), sous séreuse (43%). Le traitement était conservateur dans 71.82% des cas. Conclusion Sur la base des résultats obtenus, la mise au point d'un programme national de sensibilisation et de dépistage précoce, s'impose PMID:23847704

European Energy Security and Nord Stream: A Case Study of the Nord Stream Pipeline, Its Opportunities and Risks for Europe, and Its Impact on European Energy Security

DTIC Science & Technology

2011-06-01

Union is willing to reduce its greenhouse gas emissions by 20% by 2020 and increase the overall share of renewables by 20% by 2020,4 fossil fuels will...Europe‘s climate change opportunity.‖ It addresses two key targets—the reduction of 20% of all greenhouse gas emissions by 2020 and a 20% share of the...fuels are accountable for the biggest part of greenhouse gas emissions , and invest in new CO2- 88

Influence of uranium on bacterial communities: a comparison of natural uranium-rich soils with controls.

PubMed

Mondani, Laure; Benzerara, Karim; Carrière, Marie; Christen, Richard; Mamindy-Pajany, Yannick; Février, Laureline; Marmier, Nicolas; Achouak, Wafa; Nardoux, Pascal; Berthomieu, Catherine; Chapon, Virginie

2011-01-01

This study investigated the influence of uranium on the indigenous bacterial community structure in natural soils with high uranium content. Radioactive soil samples exhibiting 0.26% - 25.5% U in mass were analyzed and compared with nearby control soils containing trace uranium. EXAFS and XRD analyses of soils revealed the presence of U(VI) and uranium-phosphate mineral phases, identified as sabugalite and meta-autunite. A comparative analysis of bacterial community fingerprints using denaturing gradient gel electrophoresis (DGGE) revealed the presence of a complex population in both control and uranium-rich samples. However, bacterial communities inhabiting uraniferous soils exhibited specific fingerprints that were remarkably stable over time, in contrast to populations from nearby control samples. Representatives of Acidobacteria, Proteobacteria, and seven others phyla were detected in DGGE bands specific to uraniferous samples. In particular, sequences related to iron-reducing bacteria such as Geobacter and Geothrix were identified concomitantly with iron-oxidizing species such as Gallionella and Sideroxydans. All together, our results demonstrate that uranium exerts a permanent high pressure on soil bacterial communities and suggest the existence of a uranium redox cycle mediated by bacteria in the soil.

Influence of Uranium on Bacterial Communities: A Comparison of Natural Uranium-Rich Soils with Controls

PubMed Central

Mondani, Laure; Benzerara, Karim; Carrière, Marie; Christen, Richard; Mamindy-Pajany, Yannick; Février, Laureline; Marmier, Nicolas; Achouak, Wafa; Nardoux, Pascal; Berthomieu, Catherine; Chapon, Virginie

2011-01-01

This study investigated the influence of uranium on the indigenous bacterial community structure in natural soils with high uranium content. Radioactive soil samples exhibiting 0.26% - 25.5% U in mass were analyzed and compared with nearby control soils containing trace uranium. EXAFS and XRD analyses of soils revealed the presence of U(VI) and uranium-phosphate mineral phases, identified as sabugalite and meta-autunite. A comparative analysis of bacterial community fingerprints using denaturing gradient gel electrophoresis (DGGE) revealed the presence of a complex population in both control and uranium-rich samples. However, bacterial communities inhabiting uraniferous soils exhibited specific fingerprints that were remarkably stable over time, in contrast to populations from nearby control samples. Representatives of Acidobacteria, Proteobacteria, and seven others phyla were detected in DGGE bands specific to uraniferous samples. In particular, sequences related to iron-reducing bacteria such as Geobacter and Geothrix were identified concomitantly with iron-oxidizing species such as Gallionella and Sideroxydans. All together, our results demonstrate that uranium exerts a permanent high pressure on soil bacterial communities and suggest the existence of a uranium redox cycle mediated by bacteria in the soil. PMID:21998695

The effects on cow performance and calf birth and weaning weight of replacing grass silage with brewers grains in a barley straw diet offered to pregnant beef cows of two different breeds.

PubMed

Rooke, J A; Duthie, C-A; Hyslop, J J; Morgan, C A; Waterhouse, T

2016-08-01

The effects on cow and calf performance of replacing grass silage with brewers grains in diets based on barley straw and fed to pregnant beef cows are reported. Using a 2 × 2 factorial arrangement of breed and diet, cows pregnant by artificial insemination (n = 34) of two breeds (cross-bred Limousin, n = 19 and pure-bred Luing, n = 15) were fed diets ad libitum which consisted of either (g/kg dry matter) barley straw (664) and grass silage (325; GS) or barley straw (783) and brewers grains (206, BG) and offered as total mixed rations. From gestation day (GD) 168 until 266, individual daily feed intakes were recorded and cow body weight (BW) and body condition score (BCS) measured weekly. Calving date, calf sex, birth and weaning BW, and calf age at weaning were also recorded. Between GD 168 and 266, cross-bred Limousin cows gained more weight than Luing cows (p < 0.05) and cows offered BG gained more weight than cows offered GS (p < 0.001). Luing cows lost more BCS than cross-bred Limousin cows (p < 0.05), but diet did not affect BCS. There were no differences in dry matter intake as a result of breed or diet. Calf birth BW, however, was greater for cows fed BG than GS (44 vs. 38 kg, SEM 1.0, p < 0.001) with no difference between breeds. At weaning, calves born to BG-fed cows were heavier than those born to GS-fed cows (330 vs. 286 kg, SEM 9.3, p < 0.01). In conclusion, replacement of grass silage with brewers grains improved the performance of beef cows and increased calf birth and weaning BW. Further analysis indicated that the superior performance of cows offered the BG diet was most likely due to increases in protein supply which may have improved both energy and protein supply to the foetus. Journal of Animal Physiology and Animal Nutrition © 2015 Blackwell Verlag GmbH.

The NordICC Study: Rationale and design of a randomized trial on colonoscopy screening for colorectal cancer

PubMed Central

F.Kaminski, Michal; Bretthauer, Michael; Zauber, Ann G.; Kuipers, Ernst J.; Adami, Hans-Olov; van Ballegooijen, Marjolein; Regula, Jaroslaw; van Leerdam, Monique; Stefansson, Tryggvi; Påhlman, Lars; Dekker, Evelien; Hernán, Miguel A.; Garborg, Kjetil; Hoff, Geir

2017-01-01

Background While colonoscopy screening is widely used in several European countries and the United States, no randomised trials exist to quantify its benefits. The Nordic-European Initiative on Colorectal Cancer (NordICC) is a multinational, randomized controlled trial aiming at investigating the effect of colonoscopy screening on CRC incidence and mortality. This paper describes the rationale and design of the NordICC trial. Material and methods Men and women age 55 to 64 years are drawn from the population registries in the participating countries and randomly assigned to either once-only colonoscopy screening with removal of all detected lesions, or no screening (standard of care in the trial regions). All individuals are followed for 15 years after inclusion using dedicated national registries. Results The primary endpoints of the trial are cumulative CRC-specific death and CRC incidence during 15 years of follow up. We hypothesize a 50% CRC mortality-reducing efficacy of the colonoscopy intervention and predict 50% compliance, yielding a 25% mortality reduction among those invited to screening. For 90% power and a two-sided alpha level of 0.05, using a 2:1 randomisation, 45,600 individuals will be randomised to control, and 22,800 individuals to the colonoscopy group. Interim analyses of the effect of colonoscopy on CRC incidence and mortality will be performed at 10 years follow-up. Conclusions The aim of the NordICC trial is to quantify the effectiveness of population-based colonoscopy screening. This will allow development of evidence-based guidelines for CRC screening in the general population. PMID:22723185

Cohort profile: the Nordic Antireflux Surgery Cohort (NordASCo).

PubMed

Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål; Tryggvadóttir, Laufey; Euler-Chelpin, My von; Lagergren, Jesper

2017-06-08

To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries). Data regarding cancer, other diseases and mortality were retrieved from the nationwide registries for cancer, patients and causes of death, respectively. The NordASCo includes 945 153 individuals with a diagnosis of GORD. Of these, 48 433 (5.1%) have undergone primary antireflux surgery. Median age at primary antireflux surgery ranged from 47 to 52 years in the different countries. The coding practices of GORD seem to have differed between the Nordic countries. The NordASCo will initially be used to analyse the risk of developing known or potential GORD-related cancers, that is, tumours of the oesophagus, stomach, larynx, pharynx and lung, and to evaluate the mortality in the short-term and long-term perspectives. Additionally, the cohort will be used to evaluate the risk of non-malignant respiratory conditions that might be caused by aspiration of gastric contents. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Nationwide incidence of motor neuron disease using the French health insurance information system database.

PubMed

Kab, Sofiane; Moisan, Frédéric; Preux, Pierre-Marie; Marin, Benoît; Elbaz, Alexis

2017-08-01

There are no estimates of the nationwide incidence of motor neuron disease (MND) in France. We used the French health insurance information system to identify incident MND cases (2012-2014), and compared incidence figures to those from three external sources. We identified incident MND cases (2012-2014) based on three data sources (riluzole claims, hospitalisation records, long-term chronic disease benefits), and computed MND incidence by age, gender, and geographic region. We used French mortality statistics, Limousin ALS registry data, and previous European studies based on administrative databases to perform external comparisons. We identified 6553 MND incident cases. After standardisation to the United States 2010 population, the age/gender-standardised incidence was 2.72/100,000 person-years (males, 3.37; females, 2.17; male:female ratio = 1.53, 95% CI1.46-1.61). There was no major spatial difference in MND distribution. Our data were in agreement with the French death database (standardised mortality ratio = 1.01, 95% CI = 0.96-1.06) and Limousin ALS registry (standardised incidence ratio = 0.92, 95% CI = 0.72-1.15). Incidence estimates were in the same range as those from previous studies. We report French nationwide incidence estimates of MND. Administrative databases including hospital discharge data and riluzole claims offer an interesting approach to identify large population-based samples of patients with MND for epidemiologic studies and surveillance.

Room temperature current-voltage (I-V) characteristics of Ag/InGaN/n-Si Schottky barrier diode

NASA Astrophysics Data System (ADS)

Erdoğan, Erman; Kundakçı, Mutlu

2017-02-01

Metal-semiconductors (MSs) or Schottky barrier diodes (SBDs) have a significant potential in the integrated device technology. In the present paper, electrical characterization of Ag/InGaN/n-Si Schottky diode have been systematically carried out by simple Thermionic method (TE) and Norde function based on the I-V characteristics. Ag ohmic and schottky contacts are deposited on InGaN/n-Si film by thermal evaporation technique under a vacuum pressure of 1×10-5 mbar. Ideality factor, barrier height and series resistance values of this diode are determined from I-V curve. These parameters are calculated by TE and Norde methods and findings are given in a comparetive manner. The results show the consistency for both method and also good agreement with other results obtained in the literature. The value of ideality factor and barrier height have been determined to be 2.84 and 0.78 eV at room temperature using simple TE method. The value of barrier height obtained with Norde method is calculated as 0.79 eV.

Groundwater-flow modeling in the Yucatan karstic aquifer, Mexico

NASA Astrophysics Data System (ADS)

González-Herrera, Roger; Sánchez-y-Pinto, Ismael; Gamboa-Vargas, José

2002-09-01

The current conceptual model of the unconfined karstic aquifer in the Yucatan Peninsula, Mexico, is that a fresh-water lens floats above denser saline water that penetrates more than 40 km inland. The transmissivity of the aquifer is very high so the hydraulic gradient is very low, ranging from 7-10 mm/km through most of the northern part of the peninsula. The computer modeling program AQUIFER was used to investigate the regional groundwater flow in the aquifer. The karstified zone was modeled using the assumption that it acts hydraulically similar to a granular, porous medium. As part of the calibration, the following hypotheses were tested: (1) karstic features play an important role in the groundwater-flow system; (2) a ring or belt of sinkholes in the area is a manifestation of a zone of high transmissivity that facilitates the channeling of groundwater toward the Gulf of Mexico; and (3) the geologic features in the southern part of Yucatan influence the groundwater-flow system. The model shows that the Sierrita de Ticul fault, in the southwestern part of the study area, acts as a flow barrier and head values decline toward the northeast. The modeling also shows that the regional flow-system dynamics have not been altered despite the large number of pumping wells because the volume of water pumped is small compared with the volume of recharge, and the well-developed karst system of the region has a very high hydraulic conductivity. Résumé. Le modèle conceptuel classique de l'aquifère karstique libre de la péninsule du Yucatan (Mexique) consiste en une lentille d'eau douce flottant sur une eau salée plus dense qui pénètre à plus de 40 km à l'intérieur des terres. La transmissivité de l'aquifère est très élevée, en sorte que le gradient hydraulique est très faible, compris entre 7 et 10 mm/km dans la plus grande partie du nord de la péninsule. Le modèle AQUIFER a été utilisé pour explorer les écoulements souterrains régionaux dans cet aquifère. La zone karstifiée a été modélisée en posant l'hypothèse qu'il fonctionne hydrauliquement comme un milieu poreux granulaire. Au cours de la calibration, les hypothèses suivantes ont été testées: (1) les phénomènes karstiques jouent un rôle important dans le système aquifère, (2) un anneau ou une ceinture de dépressions dans la région est la manifestation d'une zone à forte transmissivité qui permet l'écoulement en conduits de l'eau souterraine en direction du Golfe du Mexique, et (3) la situation géologique dans la partie sud du Yucatan détermine les écoulements souterrains. Le modèle montre que la faille de la Sierrita de Ticul, dans la partie sud-ouest de la région étudiée, joue le rôle de barrière et que les valeurs de la piézométrie décroissent en direction du nord-est. La modélisation montre également que la dynamique du système aquifère à l'échelle régionale n'a pas été modifiée malgré le grand nombre de puits de pompage, parce que le volume pompé est faible en comparaison du volume de recharge; en outre, le réseau karstique très bien développé dans cette région possède une très forte conductivité hydraulique. Resumen. El modelo conceptual actual del acuífero cárstico no confinado de la Península de Yucatán (México) es el de un lentejón de agua dulce flotando sobre agua salada, más densa, la cual penetra más de 40 kilómetros tierra adentro. Debido a la alta conductividad hidráulica del acuífero, existe un gradiente hidráulico muy bajo cuyo rango está entre 7 y 10 milímetros por kilómetro en la porción norte de la península. Se utilizó el código AQUIFER para investigar el sistema de flujo de las aguas subterráneas a escala regional en el acuífero. La zona carstificada se modeló suponiendo que actúa hidráulicamente como un medio poroso granular. Como parte de la calibración, se probaron las siguientes hipótesis: (1) las características cársticas desempeñan un papel importante en el sistema de flujo de agua subterránea (2) un anillo o cinturón de sumideros en el área es una manifestación de una zona de alta transmisividad que conduce las aguas subterráneas hacia el Golfo de México y (3) las propiedades geológicas de la porción sur de Yucatán influyen en el sistema de flujo de agua subterránea. El modelo demostró que la falla de la Sierrita de Ticul, situada en el sudoeste de la zona de estudio, actúa como una barrera al flujo, y que los niveles piezométricos disminuyen hacia el nordeste. La modelación también mostró que la dinámica del sistema de flujo regional no ha sido alterada a pesar de la gran cantidad de captaciones, ya que el volumen extraído es pequeño en comparación con la recarga al acuífero además, el sistema cárstico de la región, bien desarrollado, posee una conductividad hidráulica muy elevada.

Uranium in Holocene valley-fill sediments, and uranium, radon, and helium in waters, Lake Tahoe-Carson Range area, Nevada and California, U.S.A.

USGS Publications Warehouse

Otton, J.K.; Zielinski, R.A.; Been, J.M.

1989-01-01

Uraniferous Holocene sediments occur in the Carson Range of Nevada and California, U.S.A., between Lake Tahoe and Carson Valley. The hosts for the uranium include peat and interbedded organic-rich sand, silt, and mud that underly valley floors, fens, and marshes along stream valleys between the crest of the range and the edge of Lake Tahoe. The known uranium accumulations extend along the Carson Range from the area just southeast of South Lake Tahoe northward to the area just east of Carson City; however, they almost certainly continue beyond the study area to the north, west, and south. Due to the young age of the accumulations, uranium in them is in gross disequilibrium with its highly radioactive daughter products. These accumulations have thus escaped discovery with radiation detection equipment in the past. The uranium content of these sediments approaches 0.6 percent; however, the average is in the range of 300-500 ppm. Waters associated with these sediments locally contain as much as 177 ppb uranium. Modest levels of helium and radon also occur in these waters. Uraniferous waters are clearly entering the private and public water supply systems in some parts of the study area; however, it is not known how much uranium is reaching users of these water supplies. Many of the waters sampled in the study area exceed the published health effects guidance level of the Environmental Protection Agency. Regulatory standards for uranium in waters have not been published, however. Much uranium is stored in the sediments along these stream valleys. Estimates for a marsh and a fen along one drainage are 24,000 and 15,000 kg, respectively. The potential effects of man-induced environmental changes on the uranium are uncertain. Laboratory studies of uraniferous sediment rich in organic matter may allow us to evaluate the potential of liberating uranium from such sediments and creating transient increases in the level of uranium moving in water in the natural environment. ?? 1989 Springer-Verlag New York Inc.

Evaluation d'un ecosysteme pastoral sahelien: Apport de la geomatique (Oursi, Burkina Faso)

NASA Astrophysics Data System (ADS)

Kabore, Seraphine Sawadogo

L'objectif principal de cette recherche est la mise au point d'une architecture d'integration de donnees socio-bio-geographiques et de donnees satellitales dans un Systeme d'Information Geographique (SIG) en vue d'une aide a la prise de decisions dans un environnement semi-aride au nord du Burkina Faso. Elle repond a la question fondamentale de l'interpretation des effets des facteurs climatiques et socioeconomiques sur le milieu pastoral. La recherche s'est appuyee sur plusieurs hypotheses de travail: possibilite d'utilisation de modele de simulation, d'approche multicritere et de donnees de teledetection dans un cadre de systeme d'information geographique. L'evolution spatiotemporelle des parametres de productivite du milieu a ete evaluee par approche dynamique selon le modele de Wu et al. (1996) qui modelise les interactions entre le climat, le milieu physique, le vegetal et l'animal pour mieux quantifier la biomasse primaire. A ce modele, quatre parametres ont ete integres par approche floue et multicritere afin de prendre en compte la dimension socioeconomique de la productivite pastorale (apport majeur de la recherche): la sante, l'education, l'agriculture et l'eau. La teledetection (imagerie SPOT) a permis de definir la production primaire a partir de laquelle les simulations ont ete realisees sur 10 annees. Les resultats obtenus montrent une bonne correlation entre biomasse primaire in situ et celle calculee pour les deux modeles, avec toutefois une meilleure efficacite du modele modifie (4 fois plus) dans les zones de forte productivite ou l'on note un taux de surexploitation agricole eleve. A cause de la variabilite spatiale de la production primaire in situ, les erreurs des resultats de simulation (8 a 11%) sont acceptables et montrent la pertinence de l'approche grace a l'utilisation des SIG pour la spatialisation et l'integration des differents parametres des modeles. Les types de production secondaire preconises (production de lait pendant 7 mois ou de viande pendant 6 mois) sont bases sur les besoins de l'UBT et le disponible fourrager qui est de qualite mediocre en saison seche. Dans les deux cas de figure, un deficit fourrager est observe. Deux types de transhumance sont proposes afin d'assurer une production durable selon deux scenarios: exploitation rationnelle des unites pastorales selon un plan de rotation annuelle et mise en defens a moyen terme des zones degradees pour une regeneration. Les zones potentielles pour la transhumance ont ete determinees selon les limites acceptables des criteres d'exploitation durable des milieux saheliens definis par Kessler (1994) soit 0,2 UBT.ha-1.

Highlights from the CERN/ESO/NordForsk ''Gender in Physics Day''

NASA Astrophysics Data System (ADS)

Primas, F.; Guinot, G.; Strandberg, L.

2017-03-01

In their role as observers on the EU Gender Equality Network in the European Research Area (GENERA) project, funded under the Horizon 2020 framework, CERN, ESO and NordForsk joined forces and organised a Gender in Physics Day at the CERN Globe of Science and Innovation. The one-day conference aimed to examine innovative activities promoting gender equality, and to discuss gender-oriented policies and best practice in the European Research Area (with special emphasis on intergovernmental organisations), as well as the importance of building solid networks. The event was very well attended and was declared a success. The main highlights of the meeting are reported.

Health state after treatment: a reason for discrimination?

PubMed

Abellan-Perpiñan, J M; Pinto-Prades, J L

1999-12-01

In this paper the issue of discrimination between patients based on the health improvement that each can achieve is addressed. Previous research in this area by Nord has shown that, in this context, society's preferences may be quite opposite to the principle of health maximization present in cost utility analysis. Using a different experimental design from that used by Nord, some results are achieved which suggest that social preferences may be somewhere in between two opposite extremes, which are that discrimination based on the degree of health improvement is never acceptable and that discrimination based on the degree of health improvement is always acceptable. Copyright 1999 John Wiley & Sons, Ltd.

Genetics Home Reference: Laing distal myopathy

MedlinePlus

... Muscular Dystrophy Association: Facts About Rare Muscular Dystrophies (PDF) Muscular Dystrophy Canada Muscular Dystrophy UK National Organization for Rare Disorders (NORD): Distal Myopathy Resource list ...

Genetics Home Reference: myotonia congenita

MedlinePlus

... Manual Consumer Version: Congenital Myopathies Orphanet: Thomsen and Becker disease Patient Support and Advocacy Resources (3 links) Muscular Dystrophy Association National Organization for Rare Disorders (NORD) Resource ...

Summary of reconnaissance for radioactive deposits in Alaska, 1945-1954, and an appraisal of Alaskan uranium possibilities

USGS Publications Warehouse

Wedow, Helmuth

1956-01-01

In the period 1945-1954 over 100 investigations for radioactive source materials were made in Alaska. The nature of these investigations ranged from field examinations of individual prospects or the laboratory analysis of significantly radioactive samples submitted by prospectors to reconnaissance studies of large districts. In this period no deposits of uranium or thorium that would warrant commercial exploitation were discovered. The investigations, however, disclosed that radioactive materials occur in widely scattered areas of Alaska and in widely diverse environments. Many igneous rocks throughout Alaska are weakly radioactive because of uranium- and thorium-bearing accessory minerals, such as allanite, apatite, monazite, sphene, xenotime, and zircon; more rarely the radioactivity of these rocks is due to thorianite or thorite and their uranoan varieties. The felsic rocks, for example, granites and syenites, are generally more radioactive than the mafic igneous rocks. Pegmatites, locally, have also proved to be radioactive, but they have little commercial significance. No primary uranium oxide minerals have been found yet in Alaskan vein deposits, except, perhaps, for a mineral tentatively identified as pitchblende in the Hyder district of southeastern Alaska. However, certain occurrences of secondary uranium minerals, chiefly those of the uranite group, on the Seward Peninsula, in the Russian Mountains, and in the vicinity of Kodiak suggest that pitchblende-type ores may occur at depth beneath zones of alteration. Thorite-bearing veins have been discovered on Prince of Wales Island in southeastern Alaska. Although no deposits or carnotite-type minerals have been found in Alaska, several samples containing such minerals have been submitted by Alaskan prospectors. Efforts to locate the deposits from which these minerals were obtained have been unsuccessful, but review of available geologic data suggests that several Alaskan areas are potentially favorable for carnotite-type deposits. The chief of these areas is the Alaska Peninsula-Cook Inlet area which encompasses most of the reported occurrences of the prospectors' carnotite-type samples. Alaska is also potentially favorable for the occurrence of large bodies of the very low-grade uraniferous sedimentary rocks, such as phosphorites and black shales. This type of deposit, however, has not received much study because of the emphasis on the search for bonanza-type high-grade ores. Uraniferous phosphorites similar to those of Idaho, Montana, and Wyoming occur in northern Alaska on the north flank of the Brooks Range; black shales comparable to the uraniferous shales of the Chattanooga formation of southeastern United States have been noted along the Yukon River near the international boundary. Placer deposits in Alaska have some small potential for the production of the radioactive elements as byproducts of gold- and tin-placer mining. the placer area believed to have the relatively greatest potential in Alaska lies in the Kahiltna River valley where concentrates are known to contain such commercial minerals as ilmenite, cassiterite, platinum, and gold in addition to uranothorianite and monazite. The possibilities of the natural fluids--water and petroleum--have not yet been tested in Alaska to any great extent. Studies of fluids are in progress to determine whether they may be used to discover and define areas potentially favorable for the occurrence of uraniferous lodes.

Profil épidémiologique des hémoglobinopathies: étude transversale descriptive autour du cas index

PubMed Central

Dahmani, Fatima; Benkirane, Souad; Kouzih, Jaafar; Woumki, Aziz; Mamad, Hassan; Masrar, Azlarab

2017-01-01

Les hémoglobinopathies sont des affections constitutionnelles conséquentes à des anomalies des hémoglobines. Elles sont souvent graves dans leurs formes majeures, leur prise en charge est lourde avec un grand impact psycho-social sur les patients et leur famille. Classées parmi les maladies rares, elles sont encore insuffisamment connues des professionnels de santé. Cette méconnaissance est à l'origine d'une errance diagnostique, d'un retard dans leur prise en charge et par conséquent une morbidité et une mortalité élevée chez ces patients. L'Organisation Mondiale de la Santé (OMS) a publié en 2008 des données concernant l'épidémiologie des hémoglobinopathies: plus de 330000 cas naissent chaque année avec une hémoglobinopathie (83% des cas de drépanocytose, 17% des cas de thalassémie). Les troubles de l'hémoglobine sont responsables d'environ 3,4% des décès chez les moins de 5 ans. A l'échelle mondiale, 7% environ des femmes enceintes seraient porteuses d'une forme de la thalassémie et 1% des couples sont à risque. Toutefois, elles sont relativement fréquentes dans certaines régions du globe où les mariages consanguins sont communs. Afin de décrire les caractéristiques épidémiologiques des familles à risque d'hémoglobinopathies (étude autour du cas) dont les cas index sont suivis au service de pédiatrie à l'Hôpital Provincial El Idrisi de Kenitra au Maroc, une étude transversale descriptive a été réalisée durant deux enquêtes la première en mai 2015 et la deuxième en juin de la même année lors des journées de vaccination des cas index contre le pneumocoque. Après avoir recueilli les données épidémiologiques de nos patients, nous avons réalisé une étude biologique comportant: l'hémogramme avec étude morphologique des globules rouges en coloration MGG et numération automatique des réticulocytes; les électrophorèses de l'hémoglobine à pH alcalin (8.8) et secondairement à pH acide (5.4) sur gel d'agarose avec intégration densitométrique. 275 patients ont présenté des profils compatibles à une hémoglobinopathie. La majorité de ces malades étaient issus de mariages consanguins (83.1%) et originaires de régions situées dans le nord du Maroc. L'enquête familiale a permis de retrouver les familles à risque, chez lesquelles on note une fréquence élevée de drépanocytose. Nos résultats confirment l'existence de différents types d'hémoglobinopathies dans la population marocaine. PMID:28904678

Reconstitution de données climatiques pour l’Algérie du Nord : application des réseaux neuronaux

NASA Astrophysics Data System (ADS)

Bouaoune, Djahida; Dahmani-Megrerouche, Malika

2010-11-01

In the present context of climate change and preservation of biodiversity, the appreciation of the vulnerability of the natural ecosystems and their capacity of adaptation appears among the main preoccupations to the world level (GIEC, 2007). This assessment of the ecosystems requires the availability of climatic data, what is often made difficult by the weak density or even the absence of meteorological stations notably, to the level of the mountains zones. In order to study the climate-vegetation relationship in North Algeria, we use an automatic interpolation method, the neural network method, for the reconstitution of climatic data of the sampled sites, (1035 phytoecological samples), from the existing meteorological network (269 stations). This method is characterized by a great suppleness of non-linearity and by its capacity for reconstituting information from partial and not well-defined indications such as the case of data provided from meteorological networks. In order to reconstitution of climatic data, we use the explicate variables, longitude, latitude and altitude, the variables to explain being the rainfall and temperatures. To define the best approach, the network calibration has been activated on climatic parameters taken globally or solely, for the whole of study zone, and by geographical sector. The results of the interpolation are expressed through a climatic parameter cartography, released automatically by the MapInfo software. The reliability results obtained by this method can be appreciated by elaboration of errors maps comparing to reference data.

Genetics Home Reference: familial idiopathic basal ganglia calcification

MedlinePlus

... Children Living with Inherited Metabolic Diseases Dystonia Medical Research Foundation Family Caregiver Alliance National Ataxia Foundation National Organization for Rare Disorders (NORD) University of Kansas Medical ...

Mineralogy and geochemistry of vanadium in the Colorado Plateau

USGS Publications Warehouse

Weeks, A.D.

1961-01-01

The chief domestic source of vanadium is uraniferous sandstone in the Colorado Plateau. Vanadium is 3-, 4-, or 5-valent in nature and, as oxides or combined with other elements, it forms more than 40 minerals in the Plateau ores. These ores have been studied with regard to the relative amounts of vanadium silicates and oxide-vanadates, uranium-vanadium ratios, the progressive oxidation of black low-valent ores to high-valent carnotite-type ores, and theories of origin. ?? 1961.

Influence of the carrying vehicle in the aerospatial survey of natural radioactivity

NASA Technical Reports Server (NTRS)

Dejesusparada, N. (Principal Investigator); Martin, I. M.

1981-01-01

The importance of the choice of the carrying vehicle in aerial surveys of natural radioactivity, particularly in the location of uraniferous regions, is discussed. The results of observations depend on the exposure time, that is, the velocity and altitude the carrying vehicle can attain. Overflights of the same region using identical instrumentation but in two different types of aircraft were performed. A detailed statistical analysis of the measurements obtained during these flights demonstrates the precision of localization achievable by this method.

Photogeologic maps of the Iris SE and Doyleville SW quadrangles, Saguache County, Colorado

USGS Publications Warehouse

McQueen, Kathleen

1957-01-01

The Iris SE and Doyleville SW quadrangles, Saguache County, Colorado include part ot the Cochetopa mining district. Photogeologic maps of these quadrangles show the distribution of sedimentary rocks of Jurassic and Cretaceous age; precambrian granite, schist, and gneiss; and igneous rocks of Tertiary age. Sedimentary rocks lie on an essentially flat erosion surface on Precambrian rocks. Folds appear to be absent but faults present an extremely complex structural terrane. Uraniferous deposits occur at fault intersections in Precambriam and Mesozoic rocks.

Groundwater recharge and chemical evolution in the southern High Plains of Texas, USA

NASA Astrophysics Data System (ADS)

Fryar, Alan; Mullican, William; Macko, Stephen

2001-11-01

The unconfined High Plains (Ogallala) aquifer is the largest aquifer in the USA and the primary water supply for the semiarid southern High Plains of Texas and New Mexico. Analyses of water and soils northeast of Amarillo, Texas, together with data from other regional studies, indicate that processes during recharge control the composition of unconfined groundwater in the northern half of the southern High Plains. Solute and isotopic data are consistent with a sequence of episodic precipitation, concentration of solutes in upland soils by evapotranspiration, runoff, and infiltration beneath playas and ditches (modified locally by return flow of wastewater and irrigation tailwater). Plausible reactions during recharge include oxidation of organic matter, dissolution and exsolution of CO2, dissolution of CaCO3, silicate weathering, and cation exchange. Si and 14C data suggest leakage from perched aquifers to the High Plains aquifer. Plausible mass-balance models for the High Plains aquifer include scenarios of flow with leakage but not reactions, flow with reactions but not leakage, and flow with neither reactions nor leakage. Mechanisms of recharge and chemical evolution delineated in this study agree with those noted for other aquifers in the south-central and southwestern USA. Résumé. L'aquifère libre des Hautes Plaines (Ogallala) est le plus vaste aquifère des états-Unis et la ressource de base pour l'eau potable de la région semi-aride du sud des Hautes Plaines du Texas et du Nouveau-Mexique. Des analyses de l'eau et des sols prélevés au nord-est d'Amarillo (Texas), associées à des données provenant d'autres études dans cette région, indiquent que des processus intervenant au cours de l'infiltration contrôlent la composition de l'eau de la nappe libre dans la moitié septentrionale du sud des Hautes Plaines. Les données chimiques et isotopiques sont compatibles avec une séquence de précipitation épisodique, avec la reconcentration en solutés dans les sols des hautes terres par évapotranspiration, avec le ruissellement et l'infiltration dans les playas et les fossés (modifiée localement par l'écoulement en retour des eaux usées et des laisses d'irrigation). Des réactions probables intervenant au cours de la recharge sont l'oxydation de la matière organique, la dissolution et le dégazage du CO2, la dissolution du CaCO3, l'altération des silicates et l'échange de cations. Les données concernant Si et 14C laissent penser qu'il existe une drainance descendante à partir d'aquifères perchés vers l'aquifère des Hautes Plaines. Des modèles vraisemblables de bilan de matière pour l'aquifère des Hautes Plaines prennent en compte des scénarios d'écoulement avec drainance mais sans réactions, des écoulements avec réactions mais sans drainance et des écoulements sans réactions ni drainance. Les mécanismes de recharge et d'évolution chimique déterminés dans cette étude sont en accord avec ceux mis en évidence dans d'autres aquifères du centre sud et du sud-ouest des états-Unis. Resumen. El acuífero libre de High Plains (Ogallala) es el mayor de los Estados Unidos y supone la fuente principal de abastecimiento en la región semiárida del sur de High Plains (Texas) y de Nuevo México. Los análisis de agua y suelos realizados al nordeste de Amarillo (Texas), junto con los datos de otros estudios regionales, indican que los procesos que tienen lugar durante la recarga del acuífero controlan la composición de las aguas subterráneas en la mitad septentrional de los High Plains del Sur. Los datos isotópicos y hidroquímicos son coherentes con una secuencia de episodios de precipitación, concentración de solutos en la parte superior del suelo por evapotranspiración, escorrentía, e infiltración a través de 'playas' y zanjas (modificadas localmente por los flujos de retorno de aguas residuales y de excedentes de riego).

Mapping the radon potential of the united states: Examples from the Appalachians

USGS Publications Warehouse

Gundersen, L.C.S.; Schumann, R.R.; ,

1997-01-01

The geologic radon potential of the United States was recently assessed by the U.S. Geological Survey. Results indicate that approximately 33% of the U.S. population lives within geologic provinces where the average indoor radon levels have the potential to be greater than 4 pCi/L (147 Bq/m3). Rock types most commonly associated with high indoor radon include: 1) Uraniferous metamorphosed sediments, volcanics, and granite intrusives, especially those that are highly deformed or sheared. 2) Glacial deposits derived from uranium-bearing rocks and sediments. 3) Carboniferous, black shales. 4) Soils derived from carbonate rock, especially in karstic terrain. 5) Uraniferous fluvial, deltaic, marine, and lacustrine deposits. Different geologic terrains of the eastern United States illustrate some of the problems inherent in correlating indoor radon with geology. The Central and Southern Appalachian Highlands of the eastern United States have not been glaciated and most soils there are saprolitic, derived directly from the underlying bedrock. Regression analyses of bedrock geologic and radon parameters yield positive correlations (R > 0.5 to 0.9) and indicate that bedrock geology can account for a significant portion of the indoor radon variation. In glaciated areas of the United States such as the northern Appalachian Highlands and Appalachian Plateau, the correlation of bedrock geology to indoor radon is obscured or is positive only in certain cases. In these glaciated areas of the country, it is the type, composition, thickness, and permeability of glacial deposits, rather than the bedrock geology, that controls the radon source.

Endocrine Gland and Brain Weights of Market Weight Bulls and Steers Representing the Shorthorn Breed and Several Breed Crosses

PubMed Central

Doornenbal, H.

1974-01-01

Thyroid, adrenal, pituitary and brain weights were first determined in 1971 in 492 market weight cattle representing purebred Shorthorns and crosses of “foreign” breeds, Charolais, Simmental and Limousin with Hereford, Angus and Shorthorn. Thyroid weights were also determined in a similar group of 433 cattle the following year. The data were reported on a per 100 kg body weight basis and analyzed within the subgroups of breed of sire, breed of dam and location. The average thyroid weight per 100 kg of body weight for males within subgroups over the two years ranged from 3.99 to 8.71 g, while that for steers ranged from 3.81 to 4.41 g. The average thyroid weight for a group of 18 Limousin sired heifers was 3.71 g. The average adrenal weight per 100 kg of slaughter weight ranged from 3.66 to 4.20 g in the males and from 3.66 to 3.86 g in the steers. Pituitary weight per 100 kg body weight at slaughter ranged from 486-511 mg in bulls and from 469-510 mg in steers. Average brain weight ranged from 85.5 to 97.3 g in males and from 92.2 to 94.1 g in steers. Breed differences existed only for the pituitary gland, with Simmental sired males and steers having heavier glands than Charolais sired males and steers. Sex differences were significant for the thyroid and the brain. Thyroids of males were generally heavier than those of steers, while brains of steers were heavier than those from males. Thyroid, adrenal and brain weights were significantly different between two genetically similar purebred herds of Shorthorns. PMID:4279761

Genetics Home Reference: acromicric dysplasia

MedlinePlus

... part of the fibers that provide strength and flexibility to connective tissues, which support the bones, skin, ... Little People of America Little People UK National Organization for Rare Disorders (NORD) The MAGIC Foundation Scientific ...

Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark).

PubMed

Olsson, Ann; Togawa, Kayo; Schüz, Joachim; Le Cornet, Charlotte; Fervers, Beatrice; Oksbjerg Dalton, Susanne; Pukkala, Eero; Feychting, Maria; Skakkebæk, Niels Erik; Hansen, Johnni

2018-06-07

Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons.

Uranium in the Upper Cambrian black shale of Sweden

USGS Publications Warehouse

McKelvey, Vincent Ellis

1955-01-01

The Peltura zone of the Upper Cambrian black shales of Sweden contains about 0.02 percent uranium. Maximum amounts are present in rocks deposited in an embayment in the sea and in rocks in or closely adjacent to that part of the vertical sequence that contains maximum amounts of distillable oil, total organic matter, pyrite, and a black highly uraniferous kerogen called "kolm". Available data suggest that the precipitation of uranium is favored by a low redox potential and that the uranium in the shale matrix may be in fine-grained kolm.

Coping When You're Newly Diagnosed

MedlinePlus

... review Conflict of Interest Disclosures for PHA’s medical leadership, visit: Disclosures Last reviewed: April 2012 Support About ... Rare Disorders (NORD) awarded PHA the Abbey S. Meyers Leadership Award in 2012 for outstanding service to PHA ...

Coping with PH over the Long Term

MedlinePlus

... review Conflict of Interest Disclosures for PHA’s medical leadership, visit: Disclosures Last reviewed: April 2012 Support About ... Rare Disorders (NORD) awarded PHA the Abbey S. Meyers Leadership Award in 2012 for outstanding service to PHA ...

NORD's Patient Assistance Programs

MedlinePlus

... 486-8462 *learn more about this program* *aprender más sobre este programa* Chronic Non-Infectious Uveitis | Closed ... 486-8033 *learn more about this program* *aprender más sobre este programa* Cystinuria | Temporarily at Capacity Co- ...

Genetics Home Reference: Andermann syndrome

MedlinePlus

... callosum with neuronopathy agenesis of corpus callosum with peripheral neuropathy agenesis of corpus callosum with polyneuropathy Charlevoix disease ... Organization for Rare Disorders (NORD) The Foundation for Peripheral Neuropathy GeneReviews (1 link) Hereditary Motor and Sensory Neuropathy ...

Spring floods prediction with the use of optical satellite data in Québec

NASA Astrophysics Data System (ADS)

Roy, A.; Royer, A.; Turcotte, R.

2009-04-01

The Centre d'expertise hydrique du Québec (CEHQ) operates a distributed hydrological model, which integrates a snow model, for the management of dams in the south of Québec. It appears that the estimation of the water quantity of snowmelt in spring remains a variable with a large uncertainty and induces generally to an important error in stream flow simulation. Therefore, the National snow and ice center (NSIDC) produces, from MODIS (Moderate Resolution Imaging Spectroradiometer) data, continuous and homogeneous spatial snow cover (snow/swow-free) data on the whole territory, but with a cloud contamination. This research aims to improve the prediction of spring floods and the estimation of the rate of discharge by integrating snow cover data in the CEHQ's snow model. The study is done on two watersheds: du Nord river watershed (45,8°N) and Aux Écorces river watershed (47,9°N). The snow model used in the study (SPH-AV) is an implementation developed by the CEHQ of the snowmelt model of HYDROLTEL in is hydrological forecast system to simulate the melted water. The melted water estimated is then used as input in the empirical hydrological model MOHYSE to simulate stream flow. MODIS data are considered valid only when the cloud cover on each pixel of the watersheds is less then 30%. A pixel by pixel correction is applied to the snow pack when there is a difference between satellite snow cover and modeled snow cover. In the case of model shows to much snow, a factor is applied on temperatures by iterative process (starting from the last valid MODIS data) to melt the snow. In the opposite case, the snow quantity added to the last valid MODIS data is found by iterative process so that the pixel's snow water equivalent is equal to the nonzero neighbor minimum value. The study shows, through the simulations done on the two watersheds, the interest of the use of snow/snow-free product for the operational update of snow water equivalent with the objective to improve spring snowmelt stream flow simulations. The binary aspect (snow/snowfree) of the data is however a limit. Alternatives are discussed (passive microwave data). Keywords : satellite snow cover data, MODIS, satellite data integration, snow model, hydrological model, stream flow simulation, flood.

Nutritional assessment and follow-up of residents with and without dementia in nursing homes in the Limousin region of France: a health network initiative.

PubMed

Jesus, P; Desport, J C; Massoulard, A; Villemonteix, C; Baptiste, A; Gindre-Poulvelarie, L; Lorgueuilleux, S; Javerliat, V; Fraysse, J L; Preux, P M

2012-05-01

Limousin in France has the second oldest regional population in Europe, with people over 65-years-old who have Alzheimer's disease accounting for more than 9%. In France as a whole, a large number of residents in nursing homes (NH) have dementia, leading to many nutritional problems. LINUT is a health network that assesses the nutritional status of elderly NH residents and provides support where necessary. Aims of the present study were to use this network to evaluate the nutritional status of NH residents with and without dementia and to review changes after 4 months of intervention. A cross-sectional survey was conducted by a doctor and a dietician at baseline (T0) and 4 months (T4) among residents at the 26 NH in Limousin that agreed to take part. The evaluation criteria included presence of dementia, depression and autonomy, weight, height, body mass index, Mini Nutritional Assessement (MNA™), and a 3-day survey of food intake. The 346 residents assessed at T0 were aged 87.9±6.9 years, 83.4% were women, 66.8% had dementia, 53.3% were malnourished and 27.4% obese. Autonomy was not affected by obesity. Residents with dementia had a lower Activities of Daily Living score and a lower weight than non-demented individuals (2.2±1.2 vs. 2.7±1.7 p=0.03 and 60.1±16.3 vs. 64.7±20.0 kg p=0.03, respectively), were more often malnourished (56.1% vs. 46.4% p=0.004) and less often obese (22.0% vs. 39.1% p=0.004) but consumed more protein (62.6±17.8 vs. 58.2±16.9 g/d p=0.04, 1.1±0.4 vs. 1.0±0.4 g/kg/d p=0.005). Energy intake was at the lower limit of French recommendations (26.4±8.8 vs. >25.0 kcal/kg/d). Assessment of all residents at T4 showed improved MNA™ (+0.4 points/month p=0.02), protein intake (+3.3 g/d p=0.0007), and energy intake (+41.4 kcal/d p=0.01 and 0.1 kcal/kg/d p=0.03). Variations in prevalences of malnutrition and obesity were not statistically significant. MNA™ increased in the dementia group (+0.29±0.8 points/month p=0.003). All other changes were comparable, and nutritional status did not differ more between the two groups at T4 than at T0. The prevalence of dementia was high in the population studied. Malnutrition was the main problem, particularly if residents had dementia. Protein intake was satisfactory, but energy intake often insufficient. The nutritional status of dementia patients improved after 4 months of follow-up, suggesting that effective action to support such services would be worthwhile.

Spatial characteristics of groundwater temperature in the Ishikari Lowland, Hokkaido, northern Japan: analytical and numerical applications

NASA Astrophysics Data System (ADS)

Dim, J. R.; Sakura, Y.; Fukami, H.; Miyakoshi, A.

2002-03-01

In porous sediments of the Ishikari Lowland, there is a gradual increase in the background geothermal gradient from the Ishikari River (3-4 °C 100 m-1) to the southwest highland area (10 °C 100 m-1). However, the geothermal gradient at shallow depths differs in detail from the background distribution. In spite of convective heat-flow loss generally associated with groundwater flow, heat flow remains high (100 mW m-2) in the recharge area in the southwestern part of the Ishikari basin, which is part of an active geothermal field. In the northeastern part of the lowland, heat flow locally reaches 140 mW m-2, probably due to upward water flow from the deep geothermal field. Between the two areas the heat flow is much lower. To examine the role of hydraulic flow in the distortion of the isotherms in this area, thermal gradient vs. temperature analyses were made, and they helped to define the major components of the groundwater-flow system of the region. Two-dimensional simulation modeling aided in understanding not only the cause of horizontal heat-flow variations in this field but also the contrast between thermal properties of shallow and deep groundwater reservoirs. Résumé. Dans les sédiments poreux des basses terres d'Ishikari, on observe une augmentation graduelle du gradient géothermal général depuis la rivière Ishikari (3-4 °C 100 m-1) vers la zone élevée située au sud-ouest (10 °C 100 m-1). Toutefois, le gradient géothermal aux faibles profondeurs diffère dans le détail de la distribution générale. Malgré la perte de flux de chaleur par convection, généralement associée aux écoulements souterrains, le flux de chaleur reste élevé (100 mW m-2) dans la zone de recharge de la partie sud-ouest du bassin de l'Ishikari, qui appartient à un champ géothermal actif. Dans la partie nord-est des basses terres, le flux de chaleur atteint localement 140 mW m-2, probablement à cause d'un écoulement souterrain ascendant depuis le champ géothermal profond. Entre les deux zones, le flux de chaleur est beaucoup plus faible. Afin de déterminer le rôle du flux d'eau souterraine dans la distorsion des isothermes dans cette zone, des analyses du gradient thermal en fonction de la température ont été réalisées elles ont permis de définir les composantes majeures du système aquifère régional. Une modélisation deux-dimensionnelle pour la simulation a ensuite contribué à la compréhension non seulement de la cause des variations horizontales du flux de chaleur dans cette région, mais également du contraste entre les propriétés des réservoirs superficiel et profond. Resumen. En los sedimentos porosos de las tierras bajas de Ishikari, hay un incremento gradual en el gradiente geotérmico desde el río Ishikari (3-4 °C 100 m-1) hacia la zona elevada del sudoeste (10 °C 100 m-1). Sin embargo, el gradiente geotérmico a profundidades someras difiere de la distribución de fondo. A pesar de las pérdidas por el flujo convectivo de calor asociadas generalmente al flujo de aguas subterráneas, el flujo de calor permanece elevado (100 mW m-2) en el área de recarga, hacia el sudoeste de la cuenca del Ishikari, la cual pertenece a un campo geotérmico activo. Al nordeste de las tierras bajas, el flujo de calor alcanza 140 mW m-2, probablemente por el flujo ascendente de agua procedente del campo geotérmico profundo. Entre ambas áreas, el flujo de calor es mucho menor. Para examinar el papel del flujo hidráulico en la distorsión de las isotermas de esta región, se ha comparado el gradiente térmico con la temperatura, con lo cual se ha podido definir los componentes mayoritarios del sistema de flujo de las aguas subterráneas. El uso de modelos bidimensionales ha servido para comprender no sólo del origen de las variaciones horizontales del flujo de calor en este campo, sino también el contraste entre las propiedades térmicas de los reservorios someros y profundos de aguas subterráneas.

Flexible ACT & Resource-group ACT: Different Working Procedures Which Can Supplement and Strengthen Each Other. A Response.

PubMed

van Veldhuizen, Remmers; Delespaul, Philippe; Kroon, Hans; Mulder, Niels

2015-01-01

This article is a response to Nordén and Norlander's 'Absence of Positive Results for Flexible Assertive Community Treatment. What is the next approach?'[1], in which they assert that 'at present [there is] no evidence for Flexible ACT and… that RACT might be able to provide new impulses and new vitality to the treatment mode of ACT'. We question their analyses and conclusions. We clarify Flexible ACT, referring to the Flexible Assertive Community Treatment Manual (van Veldhuizen, 2013) [2] to rectify misconceptions. We discuss Nordén and Norlander's interpretation of research on Flexible ACT. The fact that too little research has been done and that there are insufficient positive results cannot serve as a reason to propagate RACT. However, the Resource Group method does provide inspiration for working with clients to involve their networks more effectively in Flexible ACT.

Flexible ACT & Resource-group ACT: Different Working Procedures Which Can Supplement and Strengthen Each Other. A Response#

PubMed Central

van Veldhuizen, Remmers; Delespaul, Philippe; Kroon, Hans; Mulder, Niels

2015-01-01

This article is a response to Nordén and Norlander’s ‘Absence of Positive Results for Flexible Assertive Community Treatment. What is the next approach?’[1], in which they assert that ‘at present [there is] no evidence for Flexible ACT and… that RACT might be able to provide new impulses and new vitality to the treatment mode of ACT’. We question their analyses and conclusions. We clarify Flexible ACT, referring to the Flexible Assertive Community Treatment Manual (van Veldhuizen, 2013) [2] to rectify misconceptions. We discuss Nordén and Norlander’s interpretation of research on Flexible ACT. The fact that too little research has been done and that there are insufficient positive results cannot serve as a reason to propagate RACT. However, the Resource Group method does provide inspiration for working with clients to involve their networks more effectively in Flexible ACT. PMID:25767558

The distribution and mobility of uranium in glassy and zeolitized tuff, Keg Mountain area, Utah, U.S.A.

USGS Publications Warehouse

Zielinski, R.A.; Lindsey, D.A.; Rosholt, J.N.

1980-01-01

The distribution and mobility of uranium in a diagenetically altered, 8 Ma old tuff in the Keg Mountain area, Utah, are modelled in this study. The modelling represents an improvement over similar earlier studies in that it: (1) considers a large number of samples (76) collected with good geologic control and exhibiting a wide range of alteration; (2) includes radiometric data for Th, K and RaeU (radium equivalent uranium) as well as U; (3) considers mineralogic and trace-element data for the same samples; and (4) analyzes the mineral and chemical covariation by multivariate statistical methods. The variation of U in the tuff is controlled mainly by its primary abundance in glass and by the relative abundance of non-uraniferous detritus and uraniferous accessory minerals. Alteration of glass to zeolite, even though extensive, caused no large or systematic change in the bulk concentration of U in the tuff. Some redistribution of U during diagenesis is indicated by association of U with minor alteration products such as opal and hydrous Fe-Mn oxide minerals. Isotopic studies indicate that the zeolitized tuff has been open to migration of U decay products during the last 0.8 Ma. The tuff of Keg Mountain has not lost a statistically detectable fraction of its original U, even though it has a high (??? 9 ppm) trace U content and has been extensively altered to zeolite. Similar studies in a variety of geological environments are required in order to identify the particular combination of conditions most favorable for liberation and migration of U from tuffs. ?? 1980.

Uranium deposits in Grant County, New Mexico

USGS Publications Warehouse

Granger, Harry C.; Bauer, Herman L.; Lovering, Tom G.; Gillerman, Elliot

1952-01-01

The known uranium deposits of Grant county, N. Mex., are principally in the White Signal and Black Hawk districts. Both districts are within a northwesterly-trending belt of pre-Cambrian rocks, composed chiefly of granite with included gneisses, schists, and quartzites. Younger dikes and stocks intrude the pre-Cambrian complex. The White Signal district is on the southeast flanks of the Burro Mountains; the Black Hawk district is about 18 miles northwest of the town of White Signal. In the White Signal district the seconday uranium phosphates--autunite and torbernite--occur as fracture coatings and disseminations in oxidized parts of quartz-pyrite veins, and in the adjacent mafic dikes and granites; uraniferous limonite is common locally. Most of the known uraniferous deposits are less that 50 feet in their greatest dimension. The most promising deposits in the district are on the Merry Widow and Blue Jay claims. The richest sample taken from the Merry Widow mine contained more than 2 percent uranium and a sample from the Blue Jay property contained as much as 0.11 percent; samples from the other properties were of lower grade. In the Black Hawk district pitchblende is associated with nickel, silver, and cobalt minerals in fissure veins. The most promising properties in the Black Hawk district are the Black Hawk, Alhambra, and Rose mines. No uranium analyses from this district were available in 1951. There are no known minable reserves of uranium ore in either district, although there is some vein material at the Merry Widow mine of ore grade, if a market were available in the region.

A 20-ka reconstruction of a Sahelo-Sudanian paleoenvironment using multi-method dating on pedogenic carbonate

NASA Astrophysics Data System (ADS)

Diaz, Nathalie; Dietrich, Fabienne; King, Georgina E.; Valla, Pierre G.; Sebag, David; Herman, Frédéric; Verrecchia, Eric P.

2016-04-01

Soils can be precious environmental archives as they are open systems resulting from external persistent disturbance, or forcing (Jenny, 1941). Pedogenic carbonate nodules associated with clay-rich soils have been investigated in the Far North region of Cameroon in non-carbonate watersheds (Chad Basin). Nodule bearing soils have mima-like mound morphologies, within stream networks. Such settings raise questions on the processes leading to carbonate precipitation as well as landscape genesis. The mima-like mounds have been identified as degraded Vertisols, resulting from differential erosion induced by a former gilgai micro-relief (Diaz et al., 2016). Non-degraded Vertisols occur in waterlogged areas, located downstream from mima-like mound locations (Braband and Gavaud, 1985). Therefore during a former wetter period Vertisols may have been extended to the mima-like mound areas, followed by a shift toward drier conditions and erosion (Diaz et al., 2016). Consequently, mima-like mounds and associated carbonate nodules are inherited from climatic changes during the Late Pleistocene-Holocene period. The aim of this study is to validate the scenario above using the carbonate nodules collected in a mima-like mound as time archives. Optically stimulated luminescence (OSL) dating of K-feldspars trapped within the nodules is used to assess the deposition time of the soil parent material, composing the mima-like mounds. The carbonate and organic nodule parts have been radiocarbon dated with the aim of assessing the carbonate precipitation age and the age range of soil formation, respectively. Results show that the soil parent material was deposited between 18 ka and 12 ka BP and that the nodules precipitated between 7 ka and 5 ka BP. These results suggest that the deposition occurred during the arid climatic period of the Bossoumian (20 ka to 15 ka BP; Hervieu, 1970) and during the first drier part of the African Humid Period (14.8 ka to 11.5 ka BP; deMenocal et al., 2000; Armitage et al., 2015). It is thus likely that the onset of Vertisol genesis at the mima-like mound areas occurred during the main humid period (since 11.5 ka BP; Armitage et al., 2015). The carbonate nodules seem to be related to the third lacustrine transgression at the end of the African Humid Period (7 ka to 5 ka). The ages provided by radiocarbon dating on the trapped organic matter are expected to range between the OSL ages and the carbonate nodules ages. These results strengthen the scenario proposed for mima-like mounds genesis and validate their potential as palaeoclimatic archives within the Chad Basin. Armitage, S.J., Bristow, C.S., Drake, N.A., 2015. West African Monsoon Dynamics Inferred from Abrubt Fluctuations of Lake Mega-Chad. PNAS 112, 8543-8548. Brabant, P., Gavaud, M., 1985. Les sols et les ressources en terres du Nord-Cameroun, ORSTOM ed. ORSTOM, Paris. DeMenocal, P.B., Ortiz, J., Guilderson, T., Adkins, J., Sarnthein, M., Baker, L., Yarusinsky, M., 2000. Abrupt onset and termination of the African Humid Period: rapid climate responses to gradual insolation forcing. Quaternary Science Reviews 19, 347-361. Diaz, N., Dietrich, F., Cailleau, G., Sebag, D., Ngounou Ngatcha, B., Verrecchia, E.P., 2016. Can Mima-like Mounds be Vertisol relics (Far North Region of Cameroon, Chad Basin)? Geomorphology XX, XXX-XXX. Hervieu, J., 1970. Influence des changements des climats Quaternaires sur le relief et les sols du Nord-Cameroun. Bull. Ass. sénég. et Quatern. Ouest afr. 25, 97-105. Jenny, H., 1941. Factors of Soil Formation. A System of Quantitative Pedology. McGrawHill, New York, N.Y., 281 pp.

Energy and the environment in the Baltic Sea region: A study of cooperative action from the Estonian perspective

NASA Astrophysics Data System (ADS)

Brauer, Alex P.

Due to their geographic proximity and shared natural resources, cooperation on energy-related and environmental issues is particularly important for the nine countries surrounding the Baltic Sea. Currently, two projects are underway that have placed the level of cooperation within the region under the microscope: the environmental management work undertaken by the Helsinki Commission for the Convention on the Protection of the Marine Environment of the Baltic Sea Area (HELCOM) and the Nord Stream pipeline project, which, when completed, will provide the direct transportation of natural gas from Russia to Germany via the Baltic seafloor. Although both have been declared inclusive and decidedly Baltic ventures by some regional actors, reception of the cooperative efforts amongst the littoral Baltic countries has been markedly different. This study addresses these varying reactions by examining Estonia's participation in and subsequent perspectives on the HELCOM and Nord Stream projects. A theoretical framework grounded in the discipline of international relations is utilized to analyze Estonia's role in the projects and its position as a small state in a regional context. The primary areas of focus are how historical experiences and current levels of cooperation in the two endeavors have shaped Estonia's responses and, ultimately, its 'realist' perception of global politics. The study concludes that Estonia appears to have more substantive participation in HELCOM than in the Nord Stream project because of the tendency of states to securitize and, thus, prioritize the energy policy area over the environmental. Estonian foreign policy behavior, however, perpetuates the state-centric and power-centered policy processes that dominate the international political system.

Past and current weight change and forearm bone loss in middle-aged women: the Nord-Trøndelag Health Study, Norway.

PubMed

Forsmo, Siri; Langhammer, Arnulf; Schei, Berit

2009-01-01

The aim of this study was to investigate the association between bone loss and weight change before and concurrently to the assessment of forearm bone loss over 4.6 years in a population-based cohort of middle-aged women followed for more than 15 years. Among 8,856 women aged 45 to 60 years attending the first Nord-Trøndelag Health Study study, Norway (1984-1986), a 35% random sample was invited for forearm densitometry at Nord-Trøndelag Health Study 2 (1995-1997), and 2,188 women (78%) attended. After an average period of 4.6 years, they were subsequently invited for follow-up densitometry in 2001, and 1,421 women (67.8%) met. Weight and height were measured on all three occasions. During the total period of observation since baseline (15.5 y), the mean weight had increased by 3.4 kg, mostly in the youngest women. Weight loss had an accelerating and weight gain a decelerating effect on bone loss, and this was observed both for weight change occurring before the bone mineral density follow-up and for concurrent weight change. The relationship between prior weight gain or loss and bone loss seemed to persist, independent of the weight change observed during the period of bone loss assessment. Despite no mechanical impact of body weight on the forearm, weight loss in midlife women seems to be associated with a long-lasting negative effect on bone and vice versa for weight gain. This is presumably explained by humoral factors.

Lively Earthquake Activity in North-Eastern Greenland

NASA Astrophysics Data System (ADS)

Larsen, Tine B.; Dahl-Jensen, Trine; Voss, Peter H.

2016-04-01

The seismograph at the Danish military outpost, Station Nord (NOR) in North East Greenland, records many regional/local earthquakes every day. Most of these events originate at the Arctic plate boundary between the Eurasian and the North American plates. The plate boundary has a particularly active segment approximately 200 km from the seismograph. Additionally we find a seismically very active region 20-30 km from NOR on the Kronprins Christian Land peninsula. The BB seismograph at NOR was installed in 2002 and later upgraded with real-time telemetry as part of the GLISN-project. Since late 2013 data from NOR have been included in routine processing at GEUS. Phase readings on some of the older data, primarily 2002-2003, have been carried out previously in connection with other projects. As a result, phase readings for more than 6000 local events, recorded exclusively at NOR, were found in the GEUS data base. During the years 2004 to 2007 four locations were occupied by temporary BB seismographs on the North coast of Greenland as part of the Law of the Sea preparatory work. Data from these stations have not previously been analyzed for local and regional events. In this study we combine the recordings from NOR with phase readings from the temporary seismographs in Northern Greenland. The local events on Kronprins Christian Land range in magnitude from less than 2 to a 4.8 event widely recorded in the region and felt by the personnel at Station Nord on August 30, 2005. Station Nord is located in the seismically most active region of Greenland.

Potentially inappropriate medication prescribing is associated with socioeconomic factors: a spatial analysis in the French Nord-Pas-de-Calais Region.

PubMed

Beuscart, Jean-Baptiste; Genin, Michael; Dupont, Corrine; Verloop, David; Duhamel, Alain; Defebvre, Marguerite-Marie; Puisieux, François

2017-07-01

potentially inappropriate medication (PIM) prescribing is common in older people and leads to adverse events and hospital admissions. to determine whether prevalence of PIM prescribing varies according to healthcare supply and socioeconomic status. all prescriptions dispensed at community pharmacies for patients aged 75 and older between 1 January  and 31 March 2012 were retrieved from French Health Insurance Information System of the Nord-Pas-de-Calais Region for patients affiliated to the Social Security scheme. PIM was defined according to the French list of Laroche. The geographic distribution of PIM prescribing in this area was analysed using spatial scan statistics. overall, 65.6% (n = 207,979) of people aged 75 years and over living in the Nord-Pas-de-Calais Region were included. Among them, 32.6% (n = 67,863) received at least one PIM. The spatial analysis identified 16 and 10 clusters of municipalities with a high and a low prevalence of PIM prescribing, respectively. Municipalities with a low prevalence of PIM were characterised by a high socioeconomic status whereas those with a high prevalence of PIM were mainly characterised by a low socioeconomic status, such as a high unemployment rate and low household incomes. Markers of healthcare supply were weakly associated with high or low prevalence clusters. significant geographic variation in PIM prescribing was observed in the study territory and was mainly associated with socioeconomic factors. © The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society.All rights reserved. For permissions, please email: journals.permissions@oup.com

Organosulfates and organic acids in Arctic aerosols: speciation, annual variation and concentration levels

NASA Astrophysics Data System (ADS)

Hansen, A. M. K.; Kristensen, K.; Nguyen, Q. T.; Zare, A.; Cozzi, F.; Nøjgaard, J. K.; Skov, H.; Brandt, J.; Christensen, J. H.; Ström, J.; Tunved, P.; Krejci, R.; Glasius, M.

2014-08-01

Sources, composition and occurrence of secondary organic aerosols in the Arctic were investigated at Zeppelin Mountain, Svalbard, and Station Nord, northeastern Greenland, during the full annual cycle of 2008 and 2010, respectively. Speciation of organic acids, organosulfates and nitrooxy organosulfates - from both anthropogenic and biogenic precursors were in focus. A total of 11 organic acids (terpenylic acid, benzoic acid, phthalic acid, pinic acid, suberic acid, azelaic acid, adipic acid, pimelic acid, pinonic acid, diaterpenylic acid acetate and 3-methyl-1,2,3-butanetricarboxylic acid), 12 organosulfates and 1 nitrooxy organosulfate were identified in aerosol samples from the two sites using a high-performance liquid chromatograph (HPLC) coupled to a quadrupole Time-of-Flight mass spectrometer. At Station Nord, compound concentrations followed a distinct annual pattern, where high mean concentrations of organosulfates (47 ± 14 ng m-3) and organic acids (11.5 ± 4 ng m-3) were observed in January, February and March, contrary to considerably lower mean concentrations of organosulfates (2 ± 3 ng m-3) and organic acids (2.2 ± 1 ng m-3) observed during the rest of the year. At Zeppelin Mountain, organosulfate and organic acid concentrations remained relatively constant during most of the year at a mean concentration of 15 ± 4 ng m-3 and 3.9 ± 1 ng m-3, respectively. However during four weeks of spring, remarkably higher concentrations of total organosulfates (23-36 ng m-3) and total organic acids (7-10 ng m-3) were observed. Elevated organosulfate and organic acid concentrations coincided with the Arctic haze period at both stations, where northern Eurasia was identified as the main source region. Air mass transport from northern Eurasia to Zeppelin Mountain was associated with a 100% increase in the number of detected organosulfate species compared with periods of air mass transport from the Arctic Ocean, Scandinavia and Greenland. The results from this study suggested that the presence of organic acids and organosulfates at Station Nord was mainly due to long-range transport, whereas indications of local sources were found for some compounds at Zeppelin Mountain. Furthermore, organosulfates contributed significantly to organic matter throughout the year at Zeppelin Mountain (annual mean of 13 ± 8%) and during Arctic haze at Station Nord (7 ± 2%), suggesting organosulfates to be important compounds in Arctic aerosols.

Timing of metamorphism and exhumation in the Nordøyane ultra-high-pressure domain, Western Gneiss Region, Norway: New constraints from complementary CA-ID-TIMS and LA-MC-ICP-MS geochronology

NASA Astrophysics Data System (ADS)

Butler, J. P.; Jamieson, R. A.; Dunning, G. R.; Pecha, M. E.; Robinson, P.; Steenkamp, H. M.

2018-06-01

We present the results of a combined CA-ID-TIMS and LA-MC-ICP-MS U-Pb geochronology study of zircon and associated rutile and titanite from the Nordøyane ultra-high-pressure (UHP) domain in the Western Gneiss Region (WGR) of Norway. The dated samples include 4 eclogite bodies, 2 host-rock migmatites, and 2 cross-cutting pegmatites and leucosomes, all from the island of Harøya. Zircon from a coesite eclogite yielded an age of ca. 413 Ma, interpreted as the time of UHP metamorphism in this sample. Zircon data from the other eclogite bodies yielded metamorphic ages of ca. 413 Ma, 407 Ma, and 406 Ma; zircon trace-element data associated with 413 Ma and 407 Ma ages are consistent with eclogite-facies crystallization. In all of the eclogites, U-Pb dates from zircon cores, interpreted as the times of protolith crystallization, range from ca. 1680-1586 Ma, consistent with Gothian ages from orthogneisses in Nordøyane and elsewhere in the WGR. A zircon core age of ca. 943 Ma from one sample agrees with Sveconorwegian ages of felsic gneisses and pegmatites in the western part of the area. Migmatites hosting the eclogite bodies yielded zircon core ages of ca. 1657-1591 Ma and rim ages of ca. 395-392 Ma, interpreted as the times of Gothian protolith formation and Scandian partial melt crystallization, respectively. Pegmatite in an eclogite boudin neck yielded a crystallization age of ca. 388 Ma, interpreted as the time of melt crystallization. Rutile and titanite from 3 samples (an eclogite and two migmatites) yielded concordant ID-TIMS ages of 378-376 Ma. The results are similar to existing U-Pb data from other Nordøyane eclogites (415-405 Ma). In combination with previous pressure-temperature data from the coesite eclogite, these ages indicate that peak metamorphic conditions of 3 GPa/760 °C were reached ca. 413 Ma, followed by decompression to 1 GPa/810 °C by ca. 397 Ma and cooling below ca. 600 °C by ca. 375 Ma. The results are compatible with protracted UHP metamorphism followed by relatively slow exhumation. The question of whether partial melting began at UHP conditions is not resolved by this study.

NURE aerial gamma ray and magnetic detail survey of portions of northeast Washington. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-11-01

The Northeast Washington Survey was performed under the United States Department of Energy's National Uranium Resource Evaluation (NURE) Program, which is designed to provide radioelement distribution information to assist in assessing the uraniferous material potential of the United States. The radiometric and ancilliary data were digitally recorded and processed. The results are presented in the form of stacked profiles, contour maps, flight path maps, statistical tables and frequency distribution histograms. These graphical outputs are presented at a scale of 1:62,500 and are contained in the individual Volume 2 reports.

Hydrochemical tracers in the middle Rio Grande Basin, USA: 1. Conceptualization of groundwater flow

NASA Astrophysics Data System (ADS)

Plummer, L. Niel; Bexfield, Laura M.; Anderholm, Scott K.; Sanford, Ward E.; Busenberg, Eurybiades

Chemical and isotopic data for groundwater from throughout the Middle Rio Grande Basin, central New Mexico, USA, were used to identify and map groundwater flow from 12 sources of water to the basin, evaluate radiocarbon ages, and refine the conceptual model of the Santa Fe Group aquifer system. Hydrochemical zones, representing groundwater flow over thousands to tens of thousands of years, can be traced over large distances through the primarily siliciclastic aquifer system. The locations of the hydrochemical zones mostly reflect the ``modern'' predevelopment hydraulic-head distribution, but are inconsistent with a trough in predevelopment water levels in the west-central part of the basin, indicating that this trough is a transient rather than a long-term feature of the aquifer system. Radiocarbon ages adjusted for geochemical reactions, mixing, and evapotranspiration/dilution processes in the aquifer system were nearly identical to the unadjusted radiocarbon ages, and ranged from modern to more than 30 ka. Age gradients from piezometer nests ranged from 0.1 to 2 year cm-1 and indicate a recharge rate of about 3 cm year-1 for recharge along the eastern mountain front and infiltration from the Rio Grande near Albuquerque. There has been appreciably less recharge along the eastern mountain front north and south of Albuquerque. Des données sur les éléments chimiques et les isotopes présents dans l'eau souterraine prélevée à divers endroits dans le bassin moyen du Rio Grande, au centre du Nouveau-Mexique (É-U), ont permis de déterminer l'existence et l'étendue de douze sources d'eau régionales dans le bassin, d'évaluer les âges radiocarbones et de raffiner le modèle conceptuel du système aquifère du groupe de Santa Fe. Des zones hydro-chimiques qui représentent l'écoulement de l'eau souterraine depuis des dizaines de milliers d'années peuvent être suivies sur de longues distances à travers l'aquifère principalement siliclastique. La position des zones hydro-chimiques reflète principalement la distribution moderne des charges hydrauliques mais est incohérente avec une dépression dans le niveau d'eau dans la partie centre-ouest du bassin, ce qui indique que cette dépression est un élément transitoire du système aquifère plutôt qu'un élément à long terme. Les âges radiocarbones ajustés aux réactions géochimiques et aux processus de mélange et d'évapotranspiration/dilution qui ont lieu dans l'aquifère sont presque identiques aux âges non ajustés et varient de la période moderne jusqu'à 30 ka. Les gradients d'âge établis à partir des nids de piézomètres s'étendent de 0.1 à 2 a cm-1 et suggèrent un taux de recharge d'environ 3 cm a-1 le long du front des montagnes à l'est et pour l'infiltration provenant du Rio Grande près d'Albuquerque. Il y a eu substantiellement moins de recharge le long du front des montagnes à l'est, au nord et au sud d'Albuquerque. Se utilizaron datos químicos e isotópicos de agua subterránea a lo largo de la cuenca central del río Grande, Nuevo México, EEUU, para identificar y mapear el flujo de agua subterránea de 12 fuentes de agua a la cuenca para evaluar edades por medio de radio carbon y para refinar el modelo conceptual del sistema acuífero del Grupo Santa Fé. Se puede establecer zonas hidrotérmicas que representan el flujo de agua subterránea a lo largo de miles a miles de decenas de años en grandes distancias a través del sistema acuífero principalmente siliclástico. Las ubicaciones de las zonas hidroquímicas mayormente reflejan la distribucion de la cabeza hidráulica pre-desarollo moderna pero son inconsistentes con una depresión en los niveles de agua pre-desarollo en la zona central oeste de la cuenca. Esto indica que esta depresión es un rasgo transitorio y no un rasgo de largo plazo del sistema acuífero. Las edades de radio carbon ajustadas para los procesos de reaciones geoquímicas, de mezclado y de evapotranspiración-dilución son casi idénticas a los edades de radio carbon no ajustadas oscilan en un rango desde la modernidad a 30 mil años. Las gradientes de edad de nidos de piezometros van de 0.1 a 2 años cm-1 e indican un sitio de recarga de aproximadamente 3 cm/yr para la recarga a lo largo del frente montañoso oriental e infiltración del río Grande cerca de Albuquerque. Se aprecia una recarga menor a lo largo del frente oriental de montañas al norte y al sur de Albuquerque.

Erb-Duchenne and Dejerine-Klumpke Palsies

MedlinePlus

... the U.S. and Worldwide NINDS Clinical Trials Related Information Patient Organizations March of Dimes National Organization for Rare Disorders (NORD) National Rehabilitation Information Center (NARIC) United Brachial Plexus Network See all related ... Publications Parálisis de Erb-Duchenne y Dejerine-Klumpke ...

77 FR 31295 - Notice of Intent To Request Revision and Extension of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-25

... comments concerning this notice to Mark Nord, Food Assistance Branch, Food Economics Division, Economic..., represent our Nation's commitment to the principle that no one in our country should lack the food needed...

The insertion of the non-heme FeB cofactor into nitric oxide reductase from P. denitrificans depends on NorQ and NorD accessory proteins.

PubMed

Kahle, Maximilian; Ter Beek, Josy; Hosler, Jonathan P; Ädelroth, Pia

2018-06-03

Bacterial NO reductases (NOR) catalyze the reduction of NO into N 2 O, either as a step in denitrification or as a detoxification mechanism. cNOR from Paracoccus (P.) denitrificans is expressed from the norCBQDEF operon, but only the NorB and NorC proteins are found in the purified NOR complex. Here, we established a new purification method for the P. denitrificans cNOR via a His-tag using heterologous expression in E. coli. The His-tagged enzyme is both structurally and functionally very similar to non-tagged cNOR. We were also able to express and purify cNOR from the structural genes norCB only, in absence of the accessory genes norQDEF. The produced protein is a stable NorCB complex containing all hemes and it can bind gaseous ligands (CO) to heme b 3 , but it is catalytically inactive. We show that this deficient cNOR lacks the non-heme iron cofactor Fe B . Mutational analysis of the nor gene cluster revealed that it is the norQ and norD genes that are essential to form functional cNOR. NorQ belongs to the family of MoxR P-loop AAA+ ATPases, which are in general considered to facilitate enzyme activation processes often involving metal insertion. Our data indicates that NorQ and NorD work together in order to facilitate non-heme Fe insertion. This is noteworthy since in many cases Fe cofactor binding occurs spontaneously. We further suggest a model for NorQ/D-facilitated metal insertion into cNOR. Copyright © 2018 Elsevier B.V. All rights reserved.

Uranium-bearing lignite in southwestern North Dakota

USGS Publications Warehouse

Moore, George W.; Melin, Robert E.; Kepferle, Roy C.

1954-01-01

Uranium-bearing lignite was mapped and sampled in the Bullion Butte, Sentinel Butte, HT Butte, and Chalky Buttes areas in southwestern North Dakota. The uraniferous lignite occurs at several stratigraphic positions in the Sentinel Butte member of the Fort Union formation of Paleocene age. A total of 261 samples were collected for uranium analysis from 85 localities, Lignite contained as much as 0.045 percent uranium, 10.0 percent ash, and 0.45 percent uranium in the ash was found although the average is lower. Inferred reserves for the four areas examined are estimated to be about 27 million tons of lignite in beds about 2 feet thick and containing more than 3000 tons of uranium. The lignite in beds about 2 feet thick and containing more than 3000 tons of uranium. The lignite averages more than 30 percent ash in the surface samples. The principal factor that seems to influence the uranium content of lignite beds is their stratigraphic position below the overlying rocks of the White River group of Oligocene age. All of the uranium-bearing beds closely underlie the base of the White River group. Although this relationship seems to be the controlling factor, the relative concentration of uranium may be modified by other conditions. Beds enclosed in permeable rocks are more uraniferous than beds in impermeable rocks, and thin beds have higher content of uranium than thick beds. In addition, thick lignite beds commonly have a top=preferential distribution of uranium. These and other factors suggest that the uranium is secondary and this it was introduced by ground water which had leached uranium from volcanic ash in the overlying rocks of the White River group. It is thought that the uranium is held in the lignite as part of a metallo-organic compound.

Uranium potential of precambrian rocks in the Raft River area of northwestern Utah and south-central Idaho. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Black, B.A.

1980-09-01

A total of 1214 geochemical samples were collected and analyzed. The sampling media included 334 waters, 616 stream sediments, and 264 rocks. In addition, some stratigraphic sections of Elba and Yost Quartzites and Archean metasedimentary rock were measured and sampled and numerous radiation determinations made of the various target units. Statistical evaluation of the geochemical data permitted recognition of 156 uranium anomalies, 52 in water, 79 in stream sediment, and 25 in rock. Geographically, 68 are located in the Grouse Creek Mountains, 43 in the Raft River Mountains, and 41 in the Albion Range. Interpretation of the various data leadsmore » to the conclusion that uranium anomalies relate to sparingly and moderately soluble uraniferous heavy minerals, which occur as sparse but widely distributed magmatic, detrital, and/or metamorphically segregated components in the target lithostratigraphic units. The uraniferous minerals known to occur and believed to account for the geochemical anomalies include allanite, monazite, zircon, and apatite. In some instances samarskite may be important. These heavy minerals contain uranium and geochemically related elements, such as Th, Ce, Y, and Zr, in sufficient quantities to account for both the conspicuous lithologic preference and the generally observed low amplitude of the anomalies. The various data generated in connection with this study, as well as those available in the published literature, collectively support the conclusion that the various Precambrian W and X lithostratigraphic units pre-selected for evaluation probably lack potential to host important Precambrian quartz-pebble conglomerate uranium deposits. Moreover it is also doubted that they possess any potential to host Proterozoic unconformity-type uranium deposits.« less

Multielement statistical evidence for uraniferous hydrothermal activity in sandstones overlying the Phoenix uranium deposit, Athabasca Basin, Canada

NASA Astrophysics Data System (ADS)

Chen, Shishi; Hattori, Keiko; Grunsky, Eric C.

2018-04-01

The Phoenix U deposit, with indicated resources of 70.2 M lb U3O8, occurs along the unconformity between the Proterozoic Athabasca Group sandstones and the crystalline basement rocks. Principal component analysis (PCA) is applied to the compositions of sandstones overlying the deposit. Among PCs, PC1 accounts for the largest variability of U and shows a positive association of U with rare earth elements (REEs) + Y + Cu + B + Na + Mg + Ni + Be. The evidence suggests that U was dispersed into sandstones together with these elements during the uraniferous hydrothermal activity. Uranium shows an inverse association with Zr, Hf, Th, Fe, and Ti. Since they are common in detrital heavy minerals, such heavy minerals are not the major host of U. The elements positively associated with U are high in concentrations above the deposit, forming a "chimney-like" or "hump-like" distribution in a vertical section. Their enrichment patterns are explained by the ascent of basement fluids through faults to sandstones and the circulation of basinal fluids around the deposit. The Pb isotope compositions of whole rocks are similar to expected values calculated from the concentrations of U, Th, and Pb except for sandstones close to the deposit. The data suggest that in situ decay of U and Th is responsible for the Pb isotope compositions of most sandstones and that highly radiogenic Pb dispersed from the deposit to the proximal sandstones long after the mineralization. This secondary dispersion is captured in PC8, which has low eigenvalue. The data suggests that the secondary dispersion has minor effect on the overall lithogeochemistry of sandstones.

Excrétion rénale des ions divalents après homotransplantation rénale

PubMed Central

Cartier, F.; Popovtzer, M. M.; Robinette, J.; Pinggera, W. F.; Halgrimson, C. G.; Starzl, T. E.

2010-01-01

RÉSUMÉ L’élimination rénale des ions divalents, celle du Na et du K, ont été étudiées de façon comparative dans les suites immédiates de l’homotransplantation rénale chez 6 patients. Durant la période initiale polyurique (> 3ml/mn), le taux d’excrétion du Ca filtré (Cca/Ccr), du Mg, du P, du Na et du K, est élevé et il existe une corrélation étroite et quasi constante entre l’élimination du Ca, du Mg et du Na ; la corrélation n’est pas constante entre l’élimination du Na et du K, du Mg et du K. Pendant les deux jours suivants, le taux d’excrétion diminue, sauf pour le P ; il existe encore une corrélation entre l’excrétion du Ca, du Mg et du Na, non entre celle du Na et du K, du Mg et du K. L’excrétion du Ca l’emporte sur celle du Na au cours de la première période, non au cours de la seconde. A la lumière de ces données, on envisage l’intervention possible de divers facteurs, tels l’inflation hydrosique et l’hyperazotémie préalables, l’ischémie rénale contemporaine de la transplantation, les effets de la dénervation rénale, du traitement cortisonique, de l’hyperparathyroïdie et ceux des modifications circulatoires rénales. PMID:4574592

Two new species of Indigofera L. (Leguminosae) from the Sneeuberg Centre of Floristic Endemism, Great Escarpment (Eastern and Western Cape, South Africa).

PubMed

Clark, V Ralph; Schrire, Brian D; Barker, Nigel P

2015-01-01

Two new species of Indigofera L. (Leguminosae) are described from the Sneeuberg Centre of Floristic Endemism on the southern Great Escarpment, Eastern and Western Cape Provinces, South Africa. Both species are localised high-altitude endemics. Indigoferamagnifica Schrire & V.R. Clark is confined to the summit plateau of the Toorberg-Koudeveldberg-Meelberg west of Graaff-Reinet, and complements other western Sneeuberg endemics such as Ericapasserinoides (Bolus) E.G.H. Oliv. and Faurearecondita Rourke & V.R. Clark. Indigoferaasantasanensis Schrire & V.R. Clark is confined to a small area east of Graaff-Reinet, and complements several other eastern Sneeuberg endemics such as Euryopsexsudans B. Nord & V.R. Clark and Euryopsproteoides B. Nord. & V.R. Clark. Based on morphology, both new species belong to the Cape Clade of Indigofera, supporting a biogeographical link between the Cape Floristic Region and the Sneeuberg, as well as with the rest of the eastern Great Escarpment.

Spatial relationships between tropical cyclone frequencies and population densities in Haiti since the 19th century

NASA Astrophysics Data System (ADS)

Klose, C. D.

2011-12-01

The second edition of the United Nations Global Assessment Report on Disaster Risk Reduction in 2011 outlined that the worldwide physical exposure to tropical cyclones increased by 192 per cent between 1970 and 2010. For the past 160 years, the Republic of Haiti has experienced numerous tropical storms and hurricanes which may have directly effected the country's development path. However, statistical data regarding storm frequencies and population densities in space and time show that the population's exposure in Haiti may have more negatively influenced its development than the actual number of storms and hurricanes. Haitians, in particular, those living in urban areas have been exposed to much higher tropical cyclone hazards than rural areas since the second half of the 20th century. Specifically, more storms made landfall in regions of accelerated migration/urbanization, such as, in departments Ouest, Artibonite, Nord, and Nord-Ouest with Haiti's four largest cities Port-au-Prince, Gonaives, Cap-Haitien and Port-de-Paix.

Ongoing Transmission of Onchocerca volvulus after 25 Years of Annual Ivermectin Mass Treatments in the Vina du Nord River Valley, in North Cameroon

PubMed Central

Eisenbarth, Albert; Achukwi, Mbunkah Daniel; Renz, Alfons

2016-01-01

Background Recent reports of transmission interruption of Onchocerca volvulus, the causing agent of river blindness, in former endemic foci in the Americas, and more recently in West and East Africa, raise the question whether elimination of this debilitating disease is underway after long-term treatment of the population at risk with ivermectin. The situation in Central Africa has not yet been clearly assessed. Methods and findings Entomologic data from two former endemic river basins in North Cameroon were generated over a period of 43 and 48 months to follow-up transmission levels in areas under prolonged ivermectin control. Moreover, epidemiologic parameters of animal-borne Onchocerca spp. transmitted by the same local black fly vectors of the Simulium damnosum complex were recorded and their impact on O. volvulus transmission success evaluated. With mitochondrial DNA markers we unambiguously confirmed the presence of infective O. volvulus larvae in vectors from the Sudan savannah region (mean Annual Transmission Potential 2009–2012: 98, range 47–221), but not from the Adamawa highland region. Transmission rates of O. ochengi, a parasite of Zebu cattle, were high in both foci. Conclusions/significance The high cattle livestock density in conjunction with the high transmission rates of the bovine filaria O. ochengi prevents the transmission of O. volvulus on the Adamawa plateau, whereas transmission in a former hyperendemic focus was markedly reduced, but not completely interrupted after 25 years of ivermectin control. This study may be helpful to gauge the impact of the presence of animal-filariae for O. volvulus transmission in terms of the growing human and livestock populations in sub-Saharan countries. PMID:26926855

Molecular tracing of classical swine fever viruses isolated from wild boars and pigs in France from 2002 to 2011.

PubMed

Simon, Gaëlle; Le Dimna, Mireille; Le Potier, Marie-Frédérique; Pol, Françoise

2013-10-25

There were three outbreaks of classical swine fever (CSF) in north-eastern France between 2002 and 2011. The first two occurred in April 2002 in the Moselle department, in a wild boar and pig herd, respectively, while the third occurred in April 2003, in the Bas-Rhin department, in a wild boar. A survey was subsequently implemented in wild boar and domestic pig populations, during which 43 CSF viruses (CSFVs) were genetically characterized to provide information on virus sources, trace virus evolution and help in the monitoring of effective control measures. Phylogenetic analyses, based on fragments of the 5'NTR, E2 and NS5B genes, showed that all French CSFVs could be assigned to genotype 2, subgenotype 2.3. CSFVs isolated in Moselle were classified in the "Rostock" lineage, a strain first described in 2001 in wild boar populations in the Eifel region of north-western Rhineland-Palatinate in Germany, and in Luxemburg. In contrast, the CSFVs isolated in Bas-Rhin were homologous to strains from the "Uelzen" lineage, a strain previously isolated from wild boars in south-eastern Rhineland-Palatinate, Germany, as well as in Vosges du Nord, France, during a previous outbreak that had occurred in wild boars between 1992 and 2001. The outbreak in Moselle domestic pigs was quickly resolved as it concerned only one herd. The infection in wild boars from Moselle was extinguished after a few months whereas wild boars from Bas-Rhin remained infected until 2007. Molecular tracing showed that the Bas-Rhin index virus strain evolved slightly during the period but that no strain from a novel lineage was introduced until this outbreak ended after application of a vaccination scheme for six years. Copyright © 2013 Elsevier B.V. All rights reserved.

Engaging Students with Behavior Disorders in Mathematics Practice Using the High-"p" Strategy

ERIC Educational Resources Information Center

Vostal, Brooks R.

2011-01-01

Students with emotional and behavioral disorders (EBD) demonstrate significant academic deficits across content areas (Coutinho, 1986; Lane, Barton-Arwood, Nelson, & Wehby, 2008; Nelson, Benner, Lane, & Smith, 2004; Reid, Gonzalez, Nordness, Trout, & Epstein, 2004; Ruhl & Berlinghoff, 1992). Mathematics, however, appears to be especially…

Flexitime in an Army Medical Center.

DTIC Science & Technology

1981-04-01

and Costigan (1973) conducted a longitudinal study of employee responses to the four day week in a medium-sized pharmaceutical company. The patterns...New York, New York, 1979. Nord, W.R. and Costigan, R. Worker adjustment to the four - day week : a longitudinal study. Journal of Applied Psychology, 58

Uranium minerals in Oligocene gypsum near Chadron, Dawes County, Nebraska

USGS Publications Warehouse

Dunham, R.J.

1955-01-01

Carnotite, sabugalite [HAI(UO2)4(PO4)4 • 16H2O] and autunite occur in the basal 25 feet of a 270-foot sequence of nonmarine bedded gypsum and gypsiferous clay in the Brule formation of Oligocene age about 12 miles northeast of Chadron in northeastern Dawes County, Nebraska. Uranium minerals are visible at only two localities and are associated with carbonaceous matter. Elsewhere the basal 25 feet of the gypsum sequence is interbedded with carbonate rocks and is weakly but persistently uraniferous. Uranium probably was emplaced from above by uranyl solutions rich in sulfate.

Scanning the Dawn of High-Tech Education in the North.

ERIC Educational Resources Information Center

Nelson, C. H.; Minore, J. B.

In late 1986, the Ontario government began a 4-year undertaking to establish a distance education network for northeastern and northwestern residents. The network, Contact North/Contact Nord, uses a full complement of interactive telecommunications systems to make secondary and postsecondary education more accessible regardless of community size…

Rare Disorders and Diseases

ERIC Educational Resources Information Center

Umlauf, Mary; Monaco, Jana; FitzZaland, Mary; FitzZaland, Richard; Novitsky, Scott

2008-01-01

According to the National Organization for Rare Disorders (NORD), a rare or "orphan" disease affects fewer than 200,000 people in the United States. There are more than 6,000 rare disorders that, taken together, affect approximately 25 million Americans. "Exceptional Parent" ("EP") recognizes that when a disorder affects a child or adult, it…

C-CARD: A Strategy to Improve Revising Behaviors

ERIC Educational Resources Information Center

Saddler, Bruce; Asaro-Saddler, Kristie; Thomas, Job

2015-01-01

Students with emotional and behavioral disorders (EBD) often perform well below their peers across academic areas, with lower math and reading scores and higher school failure and grade retention rates (Reid, Gonzalez, Nordness, Trout, & Epstein, 2004). However, writing is the most significant academic deficit for these students (Austinner,…

A Tool for Creating Healthier Workplaces: The Conducivity Process

ERIC Educational Resources Information Center

Karasek, Robert A.

2004-01-01

The conducivity process, a methodology for creating healthier workplaces by promoting conducive production, is illustrated through the use of the "conducivity game" developed in the NordNet Project in Sweden, which was an action research project to test a job redesign methodology. The project combined the "conducivity" hypotheses about a…

Protecting Pregnant Workers while Fighting Sexism: Work-Pregnancy Balance and Pregnant Nurses' Resistance in Québec Hospitals: Protéger les travailleuses enceintes en luttant contre le sexisme: équilibre travail-grossesse et résistance d'infirmières enceintes dans des hôpitaux québécois.

PubMed

Gravel, Anne Renée; Riel, Jessica; Messing, Karen

2017-11-01

Women's workplaces should guarantee healthy pregnancies while supporting pregnant women as workers. In Québec (Canada), a pregnant worker exposed to a "danger" for herself or her fetus may ask her employer to be reassigned to other work appropriate to her skills. This approach differs from other regulatory contexts in North America in that protection of fetal and maternal health is embedded in the health and safety legislation. The advantage is that the pregnant worker is guaranteed access to her full salary, but some may question whether specific provisions for pregnant women single out such women and produce risks for their careers or, conversely, pregnancy should receive even more special consideration. These questions are discussed using the results of a qualitative analysis of interviews with pregnant nurses, their supervisors, and their union representatives in ten hospitals in Québec. We think that the management of pregnancy under this legislation generally protects health, but that, in the absence of true employer commitment to the health of all workers, undue burdens may be placed upon other members of the work team. Résumé Les lieux de travail des femmes devraient garantir des grossesses saines tout en soutenant les femmes enceintes en tant que travailleurs. Au Québec (Canada), une travailleuse enceinte exposée à un danger pour elle-même ou son fœtus peut demander à son employeur d'être réaffectée à d'autres tãches sans danger et adaptéches à ses compétences. Cette approche diffère des autres contextes réglementaires en Amérique du Nord en ce sens que la protection de la santé foetale et maternelle est intégrée dans la législation sur la santé et la sécurité. Certains peuvent se demander si des dispositions spécifiques pour les femmes enceintes singularisent ces travailleuses et contribuent à la précarisation de leur emploi. Ou, à l'inverse, si la grossesse devrait recevoir une considération encore plus spéciale. Ces questions sont discutées à la lumière du récit d infirmières enceintes, de gestionnaires et de représentants syndicaux responsables des dossiers de conciliation travail-grossesse dans dix hôpitaux du Québec. Nous constatons que la gestion de la grossesse en vertu de cette législation est généralement protectrice de la santé, mais qu'en l'absence d'un véritable engagement de l'employeur envers la santé de tous les travailleurs, des charges excessives peuvent être imposées aux autres membres de l'équipe de travail.

Lower Devonian paleomagnetic dating of a large mafic sill along the western border of the Murzuq cratonic basin (Saharan metacraton, SE Algeria).

NASA Astrophysics Data System (ADS)

El-M. Derder, Mohamed; Maouche, Said; Liégeois, Jean-Paul; Henry, Bernard; Amenna, Mohamed; Ouabadi, Aziouz; Bellon, Hervé; Bruguier, Olivier; Bayou, Boualem; Bestandji, Rafik; Nouar, Omar; Bouabdallah, Hamza; Ayache, Mohamed; Beddiaf, Mohamed

2017-04-01

The Murzuq basin located in central North Africa, in Algeria, Libya and Niger is a key area, delineating a relictual cratonic area within the Saharan metacraton (Liégeois et al., 2013). On its western border, we discovered a very large sill ("Arrikine" sill), with a thickness up to 250m and a minimum length of 35 km. It is made of mafic rocks and is interbedded within the Silurian sediments of the Tassilis series. In the vicinity, the only known post-Pan-African magmatism is the Cenozoic volcanism in the In Ezzane area. Further south in Niger, also along the SW border of the Murzuq basin, large Paleozoic dolerite (Carte géologique du Sahara central, 1962) are probably related to the "Arrikine" sill magmatism, as they are in the same stratigraphical position. Several hundred kilometers westward and southwestward of Arrikine, Paleozoic magmatic products are known: Carboniferous basic intrusives (346 Ma; Djellit et al., 2006) are located in the Tin Serririne basin and Devonian ring complexes (407 Ma; Moreau et al, 1994) in the Aïr Mountains. For the Arrikine sill, K/Ar data gave a rejuvenation age (326 Ma) related to a K-rich aplitic phase and the LA-ICP-MS U-Pb method on zircon showed that only inherited zircons are present (0.6 to 0.7, 2.0 and 2.7 Ga ages), pointing to ages from the underlying basement corresponding to the Murzuq craton covered by Pan-African sediments (Derder et al., 2016). By contrast, a well-defined paleomagnetic pole yielded an age of 410-400 Ma by comparison with the Gondwana Apparent Polar Wander Path (APWP). This age, similar to that reported for the Aïr complexes (Moreau et al., 1994), can be correlated with the deep phreatic eruption before Pragian time thought to be at the origin of sand injections, which gave circular structures observed on different borders of the Murzuq basin (Moreau et al,. 2012). This Lower Devonian magmatism had therefore a regional extension and can be related to a "Caledonian" transtensive reactivation of the western metacratonic boundary of the Murzuq craton related to distant events along the northern Gondwana margin. References Carte géologique du Sahara central, from "carte géologique du nord ouest de l'Afrique", Centre National de la Recherche Scientifique (CNRS) edition, 1/2.000.000, 1962. Derder M.E.M., Maouche S., Liégeois J.P., Henry B., Amenna M., Ouabadi A., Bellon H., Bruguier O., Bayou B., Bestandji R., Nouar O., Bouabdallah H., Ayache M., Beddiaf M., 2016. Journal of African Earth Sciences 115, 159-176 Djellit, H., Bellon, H., Ouabadi, A., Derder, M.E.M., Henry, B., Bayou, B., Khaldi, A., Baziz, K., Merahi, M.K., 2006. Comptes Rendus Geosciences. 338, 624-631. Liégeois, J.P., Abdelsalam, M.G., Ennih, N., Ouabadi, A., 2013. Gondwana Research, 23, 220-237 Moreau, C., Demaiffe, D., Bellion, Y. and Boullier, A.M., 1994. Tectonophysics, 234, 129-146. Moreau, J., Ghienne, J.F., Hurst, A., 2012. Sedimentology, 59: 1321-1344.

Toward a Concept of Risk for Effective Military Decision Making

DTIC Science & Technology

2007-12-01

gestion intégrée du risque de 2001 par le Secrétariat du Conseil du Trésor du Canada, (b) de la doctrine interarmées sur la gestion du risque pour les...opérations des FC de 2002 et les documents de politique et les directives de l’intégration de la gestion du risque de 2005 du ministère de la Défense...a) le gouvernement du Canada dans le Cadre de gestion intégrée du risque de

An observational cohort study of patients with newly diagnosed digital ulcer disease secondary to systemic sclerosis registered in the EUSTAR database.

PubMed

Brand, Monika; Hollaender, Rebecca; Rosenberg, Daniel; Scott, Martin; Hunsche, Elke; Tyndall, Alan; Denaro, Valentina; Carreira, Patricia; Varju, Cecilia; Gabrielli, Barbara; Zingarelli, Stefania; Caramaschi, Paola; Simic-Pasalic, Katarina; Müller-Ladner, Ulf; Vasile, Massimiliano; Mihai, Carina; Rosato, Edoardo; Vacca, Alessandra; Zenone, Thierry; Mohamed, Walid A; Ancuta, Codrina; Zampogna, Giuseppe; Rednic, Simona; Jabaar, Nadia; Belloli, Laura; Pozzi, Maria R; Foti, Rosario; Walker, Ulrich A

2015-01-01

This study describes clinical characteristics, prognostic factors, and quality of life in patients with newly diagnosed (incident) digital ulcers (DU). Observational cohort study of 189 consecutive SSc patients with incident DU diagnosis identified from the EUSTAR database (22 centres in 10 countries). Data were collected from medical charts and during one prospective visit between 01/2004 and 09/2010. Median age at DU diagnosis was 51 years, majority of patients were female (88%), and limited cutaneous SSc was the most common subtype (61%). At incident DU diagnosis, 41% of patients had one DU and 59% had ≥2 DU; at the prospective visit 52% had DU. Pulmonary arterial hypertension (PAH) and multiple DU at diagnosis were associated with presence of any DU at the prospective visit (odds ratios: 4.34 and 1.32). During the observation period (median follow-up was 2 years) 127 patients had ≥1 hospitalisation. The event rate of new DU per person-year was 0.66, of DU-associated complications was 0.10, and of surgical or diagnostic procedures was 0.12. At the prospective visit, patients with ≥1 DU reported impairment in daily activities by 57%, those with 0 DU by 37%. The mean difference between patients with or without DU in the SF-36 physical component was 2.2, and in the mental component 1.4. DU patients were not routinely prescribed endothelin receptor antagonists or prostanoids. This real world cohort demonstrates that DU require hospital admission, and impair daily activity. PAH and multiple DU at diagnosis were associated with future occurrence of DU.

Cancer du sein bilatéral synchrone au Maroc: caractéristiques épidémiologiques et cliniques

PubMed Central

Boufettal, Houssine; Samouh, Naïma

2015-01-01

Préciser la fréquence, les facteurs de risque et le pronostic du cancer du sein bilatéral, à partir d'une étude rétrospective de 22 cas de cancer du sein bilatéral synchrone dans un pays du Maghreb. De 2002 à 2010, 625 patientes étaient prises en charge pour cancer du sein au service de Gynécologie-Obstétrique «C» du centre hospitalier universitaire de Casablanca. 22 cas de cancer bilatéral synchrone étaient diagnostiqués. Nos résultats sont comparés avec ceux de la littérature. La fréquence de la bilatéralité du cancer du sein synchrone était de 3,52% (22/625). L'intervalle de temps moyen entre les deux cancers est de 4 mois (0 à 6 mois). Les patientes âgées de moins de 40 ans lors du premier cancer avaient six fois plus de risque de développer un cancer au niveau du sein controlatéral que les femmes âgées de plus de 40 ans. Les patientes atteintes d'une tumeur T3 ou T4 avaient un risque neuf fois plus élevé que les autres. 90,9% (2/22) des cas des premiers cancers sont des adénocarcinomes infiltrants. Les types histologiques du premier et du douzième cancer étaient identiques dans 86,4% (19/22) des cas. Quant au pronostic, il dépend à la fois du stade du premier et du deuxième cancer et le traitement de ce dernier doit obéir aux mêmes règles du traitement du premier cancer. L'incidence du cancer bilatéral synchrone du sein est de 3,52% dans notre série. Le cancer du sein unilatéral constitue un facteur de risque de développement d'un cancer du sein controlatéral. Une surveillance à vie est nécessaire au cours d'un cancer du sein pour détecter un cancer controlatéral. PMID:26090066

Joint Operations Case Study. Weseruebung Nord: Germany’s Invasion of Norway, 1940

DTIC Science & Technology

1997-03-01

Generalleutnant Dietl, which draws heavily on Dietl’s reports and papers. See Gerda -Luise (Haenicke) Dietl and Kurt Hermann, eds., General Dietl: das...Sep. 1939-June 1941. History of the Second World War United Kingdom Military Series. Ed. J. R. M. Butler. London: HMSO, 1957. Dietl, Gerda

Examining Gender and the Academic Achievement of Students with Emotional Disturbance

ERIC Educational Resources Information Center

Rice, Elisabeth Hess; Yen, Cherng-Jyh

2010-01-01

Students with emotional disturbance (ED) have significant academic deficits (Trout, Nordness, Pierce, & Epstein, 2003; Lane, 2004). Even after identification and school intervention, students with ED continue to demonstrate limited academic achievement and high rates of drop out and school failure, with 80-90% scoring below grade level on tests of…

75 FR 23847 - Blocking of Specially Designated National Pursuant to Executive Order 13413

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... Conflict in the Democratic Republic of Congo''. DATES: The designation by the Director of OFAC of the five... President found that the situation in the Democratic Republic of the Congo constitutes an unusual and... Kivu, Congo, Democratic Republic of the; DOB 1973; POB Nord-Kivu, DRC; alt. POB Rwanda; nationality...

The Evolution of Depleted Uranium as an Environmental Risk Factor: Lessons from Other Metals

PubMed Central

Briner, Wayne E.

2006-01-01

Depleted uranium (DU) is used in both civilian and military applications. Civilian uses are primarily limited to ballast and counterweights in ships and aircraft with limited risk of environmental release. The very nature of the military use of DU releases DU into the environment. DU released into the environment from military use takes the form of large fragments that are chemically unchanged and dust in the form of oxides. DU dust is nearly insoluble, respirable and shows little mobility in the soil. Exposure to DU occurs primarily from inhalation of dust and possible hand to mouth activity. Toxicity of DU is believed to be primarily chemical in nature with radiological activity being a lesser problem. DU has been shown to have a variety of behavioral and neurological effects in experimental animals. DU has been used the Balkans, Afghanistan, and both Iraq wars and there is a high probability of its use in future conflicts. Further, other nations are developing DU weaponry; some of these nations may use DU with a greater radiological risk than those currently in use. The toxicity of DU has been studied mostly as an issue of the health of military personnel. However, many tons of DU have been left in the former theater of war and indigenous populations continue to be exposed to DU, primarily in the form of dust. Little epidemiological data exists concerning the impact of DU on these groups. It may be possible to extrapolate what the effects of DU may be on indigenous groups by examining the data on similar metals. DU has many similarities to lead in its route of exposure, chemistry, metabolic fate, target organs, and effect of experimental animals. Studies should be conducted on indigenous groups using lead as a model when ascertaining if DU has an adverse effect. PMID:16823086

Préface

NASA Astrophysics Data System (ADS)

Aspect, Alain

2004-11-01

COLOQ est une conférence regroupant, tous les deux ans, la communauté scientifique et industrielle nationale travaillant dans les domaines des lasers, de l'optique non-linéaire et de l'optique quantique. Elle s'est tenue pour sa huitième édition à Toulouse, du 3 au 5 septembre 2004, sur le campus de I'INSA. Comme il est de tradition tous les quatre ans, COLOQ était couplé avec Horizons de l'optique, avec en particulier une journée commune dont le programme avait été préparé en concertation par les deux comités scientifiques. Depuis sa création, COLOQ a pour but de favoriser les rencontres entre les chercheurs des différents laboratoires nationaux publics ou privés travaillant sur les lasers et l'optique quantique au sens large. C'est un moyen privilégié de resserrer les liens de cette communauté et d'y intégrer les jeunes chercheurs. Ces derniers y trouvent l'occasion de se connaître, de se faire connaître, de découvrir la communauté à laquelle ils appartiennent et d'élargir leurs connaissances des thèmes qui la structurent. La participation de 230 chercheurs et d'une vingtaine d'exposants de matériels spécialisés dans les lasers et l'optoélectronique témoigne de la vitalité de COLOQ et de son audience dans les laboratoires et chez les industriels de l'optique. Le programme de COLOQ 8 comportait d'une vingtaine de conférences générales données par des chercheurs de renom international, et des séances de communications par affiches, occasions privilégiées de rencontres et d'échanges. Les exposés ont porté sur des sujets particulièrement actifs au niveau national et international, avec un accent sur des thèmes importants pour la région toulousaine : contrôle cohérent, optique et nanosciences, optique et astronomie, sans oublier la traditionnelle rubrique phénomènes fondamentaux, éclectique pour ne pas dire hétéroclite, mais si représentative d'une des ambitions de COLOQ qui est d'offrir à ses participants une ouverture sur les recherches de base d'aujourd'hui qui seront peut-être les outils quotidiens de l'optique de demain. Quant aux 169 communications par affiches elles ont, suivant la règle, couvert sans restriction tous les sujets de l'optique actuelle. Ce volume spécial du Journal de Physique IV regroupe la majorité des conférences invitées et des communications par affiches. Profitant de la participation des mondes académique et industriel, un forum sur “innovation et nouveaux débouchés pour l'optique” a permis de dégager des raisons d'espoir pour l'emploi des chercheurs en optique. Enfin, renouvelant l'expérience d'éditions précédentes, la dernière demi journée a été consacrée à deux conférences qui étaient ouvertes à un public élargi, notamment les étudiants de l'université et des classes préparatoires ainsi que leurs enseignants. Si Antoine Labeyrie nous a laissés sans voix avec ses projets “hyperfuturistes” d'hypertélescopes à l'échelle du million de kilomètres, Pierre Lena nous a donné un moment de vrai bonheur en célébrant le mariage sans cesse renouvelé du toujours jeune couple que sont l'optique et l'astronomie : qu'il soit remercié aussi pour le magnifique teste publié dans ce volume. COLOQ se devait d'honorer la mémoire de deux personnalités hors du commun de l'optique, Jean Brossel et Gilbert Grynberg. Tous ceux qui avaient connu l'un ou l'autre ont pu apprécier la justesse des évocations, par d'anciens collaborateurs, de l'oeuvre scientifique mais aussi des personnalités de ces deux grands physiciens. On trouvera les textes de ces interventions émouvantes dans ce recueil. La réussite de COLOQ 8 est évidemment due; avant tout, à la qualité scientifique des présentations, mais elle repose aussi sur l'action conjuguée des comités d'organisation national et local. Au niveau local, Françoise Lozes et Jacques Vigué ont mobilisé les membres du LCAR-IRSAMC et du LAAS pour l'organisation conjointe - particulièrement réussie - de COLOQ et Horizons de l'Optique, qui ont pu bénéficier de l'aide de I'INSA pour les locaux. COLOQ ne serait pas ce qu'il est sans le généreux soutien des diverses instances publiques nationales, régionales, locales, et à la forte participation des sociétés industrielles du secteur optoélectronique et laser qui nous ont permis de maintenir les frais d'inscription à un niveau particulièrement raisonnable, en particulier pour les jeunes. Que tous ces donateurs, dont on trouvera la liste dans ce volume soient ici remerciés ! Une mention spéciale à la Société Française d'Optique qui facilite tellement l'organisation de COLOQ depuis de nombreuses années. Au moment de quitter la présidence du comité scientifique national de COLOQ, après quatre éditions m'ayant permis de parcourir l'hexagone du nord an sud et de l'est à l'ouest, je tiens à témoigner de la richesse et de la vitalité de la communauté française de l'optique, que j'ai pu apprécier aussi bien au sein du comité scientifique national que des divers comités locaux de Strasbourg, Bordeaux, Rennes, Toulouse. C'est aussi l'occasion de dire mon émerveillement renouvelé devant la vitalité de notre discipline, qui ne cesse d'ouvrir de nouveaux champs de recherche, et où des sujets très “amonts”, parfois exotiques, donnent régulièrement lieu à des développements techniques et industriels qui ont un impact sur toute la société. Je ne vois pas que cette vitalité donne le moindre signe d'essoufflement, bien au contraire - je suis sûr que les prochaines éditions de COLOQ en témoigneront, et je souhaite que ce message soit entendu par les plus jeunes qui s'interrogent sur leur avenir professionnel. Alain Aspect Orsay, printemps 2004

Mental health and wellbeing in spouses of persons with dementia: the Nord-Trøndelag Health Study.

PubMed

Ask, Helga; Langballe, Ellen Melbye; Holmen, Jostein; Selbæk, Geir; Saltvedt, Ingvild; Tambs, Kristian

2014-05-01

Caring for a spouse diagnosed with dementia can be a stressful situation and can put the caregiving partner at risk of loss of mental health and wellbeing. The main aim of this study was to investigate the relationship between dementia and spousal mental health in a population-based sample of married couples older than 55 years of age. The association was investigated for individuals living together with their demented partner, as well as for individuals whose demented partner was living in an institution. Data on dementia were collected from hospitals and nursing homes in the county of Nord-Trøndelag, Norway. These data were combined with data on spousal mental health, which were collected in a population-based health screening: the Nord-Trøndelag Health Study (HUNT). Of 6,951 participating couples (>55 years), 131 included one partner that had been diagnosed with dementia. Our results indicate that after adjustment for covariates, having a partner with dementia is associated with lower levels of life satisfaction and more symptoms of anxiety and depression than reported by spouses of elderly individuals without dementia. Spouses living together with a partner diagnosed with dementia experienced moderately lower levels of life satisfaction (0.35 standard deviation [SD]) and more symptoms of depression (0.38 SD) and anxiety (0.23 SD) than did their non-caregiving counterparts. Having a partner with dementia that resided in a nursing home was associated with clearly lower life satisfaction. Compared with non-caregivers, these spouses reported lower levels of life satisfaction (1.16 SD), and also more symptoms of depression (0.38 SD), and more symptoms of anxiety (0.42 SD). Having a partner with dementia is associated with loss of mental health and reduced life satisfaction. The risk of adverse mental health outcomes is greatest after the partner's nursing home admission.

Alcohol consumption is associated with reduced risk of Type 2 diabetes and autoimmune diabetes in adults: results from the Nord-Trøndelag health study.

PubMed

Rasouli, B; Ahlbom, A; Andersson, T; Grill, V; Midthjell, K; Olsson, L; Carlsson, S

2013-01-01

We investigated the influence of different aspects of alcohol consumption on the risk of Type 2 diabetes and autoimmune diabetes in adults. We used data from the Nord-Trøndelag Health Survey (HUNT) study, in which all adults aged ≥ 20 years from Nord-Trondelag County were invited to participate in three surveys in 1984-1986, 1995-1997 and 2006-2008. Patients with diabetes were identified using self-reports, and participants with onset age ≥ 35 years were classified as having Type 2 diabetes if they were negative for anti-glutamic acid decarboxylase (n = 1841) and as having autoimmune diabetes if they were positive for anti-glutamic acid decarboxylase (n = 140). Hazard ratios of amount and frequency of alcohol use, alcoholic beverage choice, and binge drinking and alcohol use disorders were estimated. Moderate alcohol consumption (adjusted for confounders) was associated with a reduced risk of Type 2 diabetes in men, but not in women (hazard ratio for men 10-15 g/day 0.48, 95% CI 0.28-0.77; hazard ratio for women ≥ 10 g/day 0.81, 95% CI 0.33-1.96). The reduced risk was primarily linked to consumption of wine [hazard ratio 0.93, 95% CI 0.87-0.99 (per g/day)]. No increased risk was seen in participants reporting binge drinking or in problem drinkers. The results were also compatible with a reduced risk of autoimmune diabetes associated with alcohol consumption [hazard ratio 0.70, 95% CI 0.45-1.08 (frequent consumption) and hazard ratio 0.36, 95% CI 0.13-0.97 (2-7 g/day)]. Moderate alcohol consumption associates with reduced risk of both Type 2 diabetes and autoimmune diabetes. A protective effect of alcohol intake may be limited to men. High alcohol consumption does not seem to carry an increased risk of diabetes. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.

Education et Developpement au Moyen-Nord.

ERIC Educational Resources Information Center

Charbonneau, Yvon

Humans, not things, are of primary importance when talking of development. All over the world, two separate, contradictory types of development may be seen: the first, centered on man, the second, on wealth. One of the ways in which man can gain control over his own future is through the school. It is essential to find out which type of…

Inclusive Work at a European Level: A Case Study

ERIC Educational Resources Information Center

Stephenson, Paul; Rumley, Glynis

2005-01-01

In this article, Paul Stephenson and Glynis Rumley describe the way in which educators in Kent have developed strong links with their colleagues and neighbours from Nord Pas de Calais in France. From a variety of projects undertaken, some of which were assisted by funding from European sources, children of all abilities and needs have been able to…

Depleted uranium induces neoplastic transformation in human lung epithelial cells.

PubMed

Xie, Hong; LaCerte, Carolyne; Thompson, W Douglas; Wise, John Pierce

2010-02-15

Depleted uranium (DU) is commonly used in military armor and munitions, and thus, exposure of soldiers and noncombatants is frequent and widespread. Previous studies have shown that DU has both chemical and radiological toxicity and that the primary route of exposure of DU to humans is through inhalation and ingestion. However, there is limited research information on the potential carcinogenicity of DU in human bronchial cells. Accordingly, we determined the neoplastic transforming ability of particulate DU to human bronchial epithelial cells (BEP2D). We observed the loss of contact inhibition and anchorage independent growth in cells exposed to DU after 24 h. We also characterized these DU-induced transformed cell lines and found that 40% of the cell lines exhibit alterations in plating efficiency and no significant changes in the cytotoxic response to DU. Cytogenetic analyses showed that 53% of the DU-transformed cell lines possess a hypodiploid phenotype. These data indicate that human bronchial cells are transformed by DU and exhibit significant chromosome instability consistent with a neoplastic phenotype.

The impact of homologous recombination repair deficiency on depleted uranium clastogenicity in Chinese hamster ovary cells: XRCC3 protects cells from chromosome aberrations, but increases chromosome fragmentation.

PubMed

Holmes, Amie L; Joyce, Kellie; Xie, Hong; Falank, Carolyne; Hinz, John M; Wise, John Pierce

2014-04-01

Depleted uranium (DU) is extensively used in both industry and military applications. The potential for civilian and military personnel exposure to DU is rising, but there are limited data on the potential health hazards of DU exposure. Previous laboratory research indicates DU is a potential carcinogen, but epidemiological studies remain inconclusive. DU is genotoxic, inducing DNA double strand breaks, chromosome damage and mutations, but the mechanisms of genotoxicity or repair pathways involved in protecting cells against DU-induced damage remain unknown. The purpose of this study was to investigate the effects of homologous recombination repair deficiency on DU-induced genotoxicity using RAD51D and XRCC3-deficient Chinese hamster ovary (CHO) cell lines. Cells deficient in XRCC3 (irs1SF) exhibited similar cytotoxicity after DU exposure compared to wild-type (AA8) and XRCC3-complemented (1SFwt8) cells, but DU induced more break-type and fusion-type lesions in XRCC3-deficient cells compared to wild-type and XRCC3-complemented cells. Surprisingly, loss of RAD51D did not affect DU-induced cytotoxicity or genotoxicity. DU induced selective X-chromosome fragmentation irrespective of RAD51D status, but loss of XRCC3 nearly eliminated fragmentation observed after DU exposure in wild-type and XRCC3-complemented cells. Thus, XRCC3, but not RAD51D, protects cells from DU-induced breaks and fusions and also plays a role in DU-induced chromosome fragmentation. Copyright © 2014 Elsevier B.V. All rights reserved.

Results of exploration at the Old Leyden coal mine, Jefferson County, Colorado

USGS Publications Warehouse

Gude, A.J.; McKeown, F.A.

1953-01-01

Six diamond core holes totaling 2, 201 feet were drilled by the. U, S. Bureau of Mines under contract to the U. S. Atomic Energy Commission at the Old Leyden coal mine, Jefferson County, Colo. The holes were spotted on the basis of geologic mapping by the U. S. Geological survey and were drilled to explore the lateral and downward extent of a uranium-bearing coal and the associated carnotite deposits in the adjacent sandstone° The data obtained from the diamond-core holes helped to explain the geology and structural control of the deposit. The uranium is most abundant in a coal bed that in places has been brecciated by shearing. and then altered to a hard, dense, and silicified rock. The uraniferous coal is in the nearly vertical beds of the Laramie formation of Upper Cretaceous age. Small lenticular bodies of uraniferous material, 50 feet long, 25 to 30 feet wide, and 2 to 4 feet thick, occur at intervals in the coal and silicified coal over a strike length of about 800 feet. These bodies contain 0.10 to 0.50 percent uranium. Data obtained from the drilling indicate a discontinuous radioactive zone between these higher-grade bodies; assays of samples from the cores range from 0.001 to 0.10 percent uranium. All drill holes were probed by Survey and A. E. C. logging equipment and showed anomalies where the core assayed more than 0.005 percent uranium. Material of ore grade--0.10 percent uranium--was found in one core; the rock in the other five holes was of lower grade. The presence of the radioactive zone in all holes suggests, however, that uranium is distributed irregularly in a southerly plunging deposit which is exposed in the adit, on the outcrop, and in other diamond-drill holes that were put down by the lessee.

The geochemistry of water near a surficial organic-rich uranium deposit, northeastern Washington State, U.S.A.

USGS Publications Warehouse

Zielinski, R.A.; Otton, J.K.; Wanty, R.B.; Pierson, C.T.

1987-01-01

The chemistry of three stream, three spring and six near-surface waters in the vicinity of a Holocene organic-rich uranium deposit is described, with particular emphasis on the chemistry of U. Results characterize the solution behavior of uranium as U-bearing water interacts with relatively undecomposed, surficial organic matter. Of the measured major and trace chemical species, only U is consistently highly enriched (17-318 ppb) relative to reported values for regional waters, or to literature values for waters in largely granitic terrains. R-mode factor analysis of the chemical data suggests that most U is present in a soluble form, but that some U is also associated with fine suspended particulates of clay, organic matter, or hydrous oxides. Calculations that apply thermodynamic data to predict U speciation in solution indicate the relative importance of uranyl carbonate and uranyl phosphate complexes. Analysis of more finely filtered samples (0.05 ??m vs. 0.45 ??m), and direct radiographic observations using fission-track detectors suspended in the waters indicate the presence of some uraniferous particulate matter. Application of existing thermodynamic data for uranous- and uranyl-bearing minerals indicates that all waters are undersaturated with U minerals as long as ambient Eh ??? +0.1 v. If coexisting surface and near-surface waters are sufficiently oxidizing, initial fixation of U in the deposit should be by a mechanism of adsorption. Alternatively, more reducing conditions may prevail in deeper pore waters of the organic-rich host sediments, perhaps leading to direct precipitation or diagenetic formation of U4+ minerals. A 234U 238U alpha activity ratio of 1.08 ?? 0.02 in a spring issuing from a hillslope above the deposit suggests a relatively soluble source of U. In contrast, higher activity ratios of 234U 238U (??? 1.3) in waters in contact with the uraniferous valley-fill sediments suggest differences in the nature of interaction between groundwater and the local, U-rich source rocks. ?? 1987.

Consequences experimentales des effets des fluctuations du vide sur la fluorescence parametrique et la generation du second harmonique en milieu confine

NASA Astrophysics Data System (ADS)

Robichaud, Luc

Les fluctuations du vide, qui consistent en l'apparition momentanee de particules, ce qui est permit par le principe d'incertitude de Heisenberg, joue un role primordial dans les processus photoniques, en particulier les processus non-lineaires. Par la manipulation de ces fluctuations du vide a l'aide de confinement optique, on retrouve deux phenomenes particuliers : l'intensification de la fluorescence parametrique (Walker, 2008) et l'inhibition de la generation du second harmonique (Collette, 2013). Dans ce travail, on presente les resultats dans le cas classique ; c'est-a-dire sans fluctuations du vide et confinement. Par la suite, on presente les effets des fluctuations du vide et du confinement, ce qui mene aux deux effets mentionnes. Dans le cas de la fluorescence parametrique, le bruit quantique sur le champ interne et externe est calcule, le role du desaccord de phase dans le modele est expose et une generalisation tridimensionnelle est etudiee afin de generaliser la conception du modele d'un cas unidimensionnel a un cas tridimensionnel planaire. Dans le cas de la generation du second harmonique, les difficultes d'un modele purement tridimensionnel sont exposees et ensuite le cas limite planaire est etudie.

An alternative for cost-effective remediation of depleted uranium (DU) at certain environmental restoration sites.

PubMed

Miller, M; Galloway, B; VanDerpoel, G; Johnson, E; Copland, J; Salazar, M

2000-02-01

Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon development programs, at firing practice ranges, or war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discreet, visually identifiable DU fragments mixed with native soil. That is, the bulk-averaged DU activity is quite low, while specific DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark, black metal that is nearly twice as dense as lead, but DU in the environment readily weathers (oxidizes) to a distinctive bright yellow color that is readily visible. While the specific activity (amount of radioactivity per mass of soil) of DU is relatively low and presents only a minor radiological hazard, the fact that it is radioactive and visually identifiable makes it desirable to remove the DU "contamination" from the environment. The typical approach to conducting this DU remediation is to use radiation detection instruments to identify the contaminant and separate it from the adjacent soil, packaging it for disposal as radioactive waste. This process can be performed manually or by specialized, automated equipment. Alternatively, in certain situations a more cost-effective approach might be simple mechanical or gravimetric separation of the DU fragments from the host soil matrix. At SNL/NM, both the automated and simple mechanical approaches have recently been employed. This paper discusses the pros/cons of the two approaches.

Cirque du Monde en tant qu’intervention en santé

PubMed Central

Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

2014-01-01

Résumé Objectif Présenter le programme Cirque du Monde du Cirque du Soleil et son potentiel en tant qu’intervention en soins de santé de première ligne pour les médecins de famille. Sources des données Une revue de la littérature menée dans les bases de données PubMed, Cochrane Library, PsycINFO, La Presse, Eureka, Google Scholar et Érudit à l’aide des mots-clés circus, social circus, Cirque du Monde et Cirque du Soleil. Une initiative à Montréal nommée Espace Transition qui s’inspire directement de Cirque du Monde. Communication personnelle avec le conseiller principal en formation en cirque social du Cirque du Soleil. Sélection d’études Les 50 premiers articles ou sites Internet répertoriés pour chaque mot-clé dans chacune des bases de données ciblées ont été révisés sur la base des titres et des résumés, s’il s’agissait d’un article, ou sur la base du titre et du contenu de la page, s’il s’agissait d’une page Internet. Ensuite, les articles et les sites Internet qui étudiaient un aspect du cirque social ou qui présentaient une intervention impliquant le cirque étaient retenus pour une révision. Aucune contrainte d’année de publication n’a été appliquée étant donné qu’on cherchait une littérature générale sur le cirque social. Synthèse Aucun article n’a été trouvé sur le cirque social en tant qu’intervention en santé. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention en milieu scolaire. Cette étude a démontré une augmentation de l’estime personnelle des enfants grâce à l’intervention. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention sur une réserve amérindienne. Cette étude présente des résultats qualitatifs non spécifiques au programme du cirque social. Les autres articles répertoriés n’étaient que des descriptions du cirque social. Un site web concernant l’utilisation du cirque social pour faciliter la réintégration sociale de jeunes traités en milieu hospitalier pour un trouble psychiatrique majeur a été répertorié. L’équipe du département de pédopsychiatrie du Centre hospitalier universitaire Sainte-Justine responsable de ce projet nommé Espace Transition a été contactée. Des résultats préliminaires non publiés du projet pilote montrent des améliorations significatives du fonctionnement général des patients. Selon le Cirque du Soleil, plusieurs projets de recherche portant sur l’impact thérapeutique du cirque social sont en cours à travers le monde. Conclusion Cirque du Monde rejoint une clientèle marginalisée difficilement accessible par le système de santé. Ce programme revêt un potentiel thérapeutique de par sa clientèle cible, sa promotion de saines habitudes de vie et le soutien qu’il offre par l’intermédiaire du groupe et des intervenants. Compte tenu des investissements financiers importants du Cirque du Soleil dans ce projet, le manque de littérature donnant accès à des données probantes constitue un enjeu important.

Depleted uranium contamination by inhalation exposure and its detection after approximately 20 years: implications for human health assessment.

PubMed

Parrish, Randall R; Horstwood, Matthew; Arnason, John G; Chenery, Simon; Brewer, Tim; Lloyd, Nicholas S; Carpenter, David O

2008-02-01

Inhaled depleted uranium (DU) aerosols are recognised as a distinct human health hazard and DU has been suggested to be responsible in part for illness in both military and civilian populations that may have been exposed. This study aimed to develop and use a testing procedure capable of detecting an individual's historic milligram-quantity aerosol exposure to DU up to 20 years after the event. This method was applied to individuals associated with or living proximal to a DU munitions plant in Colonie New York that were likely to have had a significant DU aerosol inhalation exposure, in order to improve DU-exposure screening reliability and gain insight into the residence time of DU in humans. We show using sensitive mass spectrometric techniques that when exposure to aerosol has been unambiguous and in sufficient quantity, urinary excretion of DU can be detected more than 20 years after primary DU inhalation contamination ceased, even when DU constitutes only approximately 1% of the total excreted uranium. It seems reasonable to conclude that a chronically DU-exposed population exists within the contamination 'footprint' of the munitions plant in Colonie, New York. The method allows even a modest DU exposure to be identified where other less sensitive methods would have failed entirely. This should allow better assessment of historical exposure incidence than currently exists.

Approche de prise en charge du trouble du spectre de l’autisme

PubMed Central

Lee, Patrick F.; Thomas, Roger E.; Lee, Patricia A.

2015-01-01

Résumé Objectif Se pencher sur les critères diagnostiques du trouble du spectre de l’autisme (TSA) comme les définit le Manuel diagnostique et statistique des troubles mentaux, cinquième édition (DSM-V), et concevoir une approche de prise en charge du TSA à l’aide du cadre CanMEDS–Médecine familiale (CanMEDS-MF). Sources d’information Le DSM-V, publié par l’American Psychiatric Association en mai 2013, énonce de nouveaux critères diagnostiques du TSA. Le cadre CanMEDS-MF du Collège des médecins de famille du Canada fournit un plan d’orientation pour la prise en charge complexe du TSA. Nous avons utilisé des données recueillies par le Centers for Disease Control and Prevention afin de déterminer la prévalence du TSA, ainsi que la revue systématique et méta-analyse détaillée effectuée par le National Institute for Health and Care Excellence du R.-U. pour ses lignes directrices sur le TSA dans le but d’évaluer les données probantes issues de plus de 100 interventions. Message principal Selon les données du Centers for Disease Control and Prevention, la prévalence du TSA se chiffrait à 1 sur 88 en 2008 aux États-Unis. La classification du TSA dans la quatrième édition du DSM incluait l’autisme, le syndrome d’Asperger, le trouble envahissant du développement et le trouble désintégratif de l’enfance. La dernière révision du DSM-V réunit tous ces troubles sous la mention TSA, avec différents niveaux de sévérité. La prise en charge du TSA est complexe; elle exige les efforts d’une équipe multidisciplinaire ainsi que des soins continus. Les rôles CanMEDS-MF fournissent un cadre de prise en charge. Conclusion Les médecins de famille sont au cœur de l’équipe de soins multidisciplinaire pour le TSA, et le cadre CanMEDS-MF tient lieu de plan détaillé pour guider la prise en charge d’un enfant atteint de TSA et aider la famille de cet enfant.

Cross-sectional, observational study of anterior segment parameters using anterior segment optical coherence tomography in North Indian Population.

PubMed

Dalal, Latika Khatri; Dhasmana, Renu; Maitreya, Amit

2017-01-01

To study the anterior segment (AS) parameters using AS optical coherence tomography (AS-OCT) in the North Indian population. A hospital-based, observational, cross-sectional study was conducted over a period of 1 year. It included 251 normal individuals aged 20-70 years. Participants underwent imaging with AS-OCT.Ocular parameters included anterior chamber angle (ACA), iris cross-sectional area (ICSA), iris thickness (IT), and iris curvature (IC). The parameters were measured nasally and temporally for both sexes and different age groups. The mean age of participants was 48.3 ± 13.9 years and 50.6% were men. The ACA decreased with age whereas ICSA, IT, and IC increased with age. The ACA (P = 0.0001nasally and temporally), ICSA (P = 0.011 nasally, P = 0.027 temporally), IT750 (P = 0.001 nasally, P = 0.011 temporally), IT1500 (P = 0.002 nasally, P = 0.002 temporally), and IC (P = 0.059 nasally, P = 0.128 temporally) underwent statistically significant changes with increasing age. No significant difference was seen in parameters of different sex. In this subset of the Indian population, the change in the AC parameters with age influences the AC dimensions predisposing the eye to glaucomatous conditions. These data are applicable clinically for the assessment and surgical management of patients requiring AS surgery. Objectif: Étudier les paramètres du segment antérieur (AS) en utilisant la tomodensitométrie optique AS (AS-OCT) dans la population du nord de l'Inde. Méthodes: Une étude axée sur l'hôpital, observationnelle et transversale a été menée sur une période de 1 an. Il comprenait 251 individus normaux âgés de 20 à 70 ans. Les participants ont subi une imagerie avec AS-OCT. Les paramètres oculaires comprenaient l'angle de la chambre antérieure (ACA), la surface transversale de l'iris (ICSA), l'épaisseur de l'iris (IT) et la courbure de l'iris (IC). Les paramètres ont été mesurés par voie nasale et temporelle pour les deux sexes et différents groupes d'âge. Résultats: l'âge moyen des participants était de 48,3 ± 13,9 ans et 50,6% des hommes. L'ACA a diminué avec l'âge alors que ICSA, IT et IC ont augmenté avec l'âge. L'ACA (P = 0,0001 par voie nasale et temporelle), ICSA (P = 0,011 nasale, P = 0,027 temporellement), IT750 (P = 0,001 par voie nasale, P = 0,011 temporellement), IT1500 (P = 0,002 par voie nasale, P = 0,002 temporellement) Et IC (P = 0,059 nasal, P = 0,128 temporellement) ont subi des changements statistiquement significatifs avec l'âge. Aucune différence significative n'a été observée dans les paramètres du sexe différent. Dans ce sous-ensemble de la population indienne, la variation des paramètres CA avec l'âge influence les dimensions AC prédisposant l'oeil aux conditions glaucomateuses. Ces données sont applicables cliniquement pour l'évaluation et la gestion chirurgicale des patients nécessitant une chirurgie AS.

Methodology for Assessing Disruptions (MAD) Game Part I: Report and Analysis

DTIC Science & Technology

2012-12-01

élaborées dans le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du...le Guide de planification fonctionnelle du groupe du SMA(S& T ). Le présent mémorandum technique est principalement destiné au Bureau du scientifique en...2010 2012-009 Principal Author Original signed by G . Adlakha-Hutcheon, M. Hazen, P. Hubbard, S. McLelland, K. Sprague G . Adlakha

Participation des médecins généralistes de la province de Benimellal (Maroc) dans le dépistage du cancer du col

PubMed Central

Nani, Samira; Benallal, Mohamed; Hassoune, Samira; Kissi, Dounia; Maaroufi, Abderrahmane

2013-01-01

Introduction Au Maroc, chaque année il y aurait environ 2000 nouveaux cas de cancer du col et les 2/3 des cas sont pris en charge à un stade très avancé. Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Méthodes Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Résultats Le niveau de connaissance était relativement modeste, 22 médecins généraliste avaient répondu à la question sur l'incidence du cancer du col au Maroc, Parmi eux (81,8%) avaient donné une réponse incorrecte. L'Herpes Papilloma virus comme facteur de risque du cancer du col a été identifié par seulement 21% des médecins généralistes. La participation au dépistage était également défaillante, 92,8% n'avaient jamais pratiqué le FCV chez leurs patientes à cause principalement du manque de formation (95,5%). Conclusion Les résultats montrent la nécessité d'améliorer les connaissances théoriques et pratique des médecins généralistes concernant le dépistage du cancer du col. PMID:23785557

A Review of Depleted Uranium Biological Effects: In vivo Studies

DTIC Science & Technology

2010-11-01

organs - Uranium retention is long-term - DU causes some neurotoxicity - DU induces genotoxicity - DU urine is mutagenic - DU causes adverse oncogene...Behavior; Locomotor Brain Accumulation Sperm Effects Immune Effects Offspring Effects Behavior Yes Yes Yes No effects Decreased Inflammatory...in Unexposed Offspring Finding: DU Internalized Exposure Induces Germ Cell DNA Damage Uranium Distribution Behavior Neurobio Histopathology Sperm

Non-destructive analysis of DU content in the NIF hohlraums

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gharibyan, Narek; Moody, Ken J.; Shaughnessy, Dawn A.

2015-12-16

The advantage of using depleted uranium (DU) hohlraums in high-yield deuterium-tritium (DT) shots at the National Ignition Facility (NIF) is addressed by Döppner, et al., in great detail [1]. This DU based hohlraum incorporates a thin layer of DU, ~7 μm thick, on the inner surface along with a thin layer of a gold coating, ~0.7 μm thick, while the outer layer is ~22 μm thick gold. A thickness measurement of the DU layer can be performed using an optical microscope where the total DU weight can be computed provided a uniform DU layer. However, the uniformity of the thicknessmore » is not constant throughout the hohlraum since CAD drawing calculations of the DU weight do not agree with the computed values from optical measurements [2]. Therefore, a non-destructive method for quantifying the DU content in hohlraums has been established by utilizing gamma-ray spectroscopy. The details of this method, along with results from several hohlraums, are presented in this report.« less

The Effects of the "Language for Learning" Programme on the Social Adjustment of Kindergarten Children

ERIC Educational Resources Information Center

Benner, Gregory J.; Zeng, Songtian

2017-01-01

The results of previous research on the "Language for Learning" programme suggest that it produces positive effects on the intellectual, language, and social skills of young children with and without disabilities [Benner, G. J., Trout, A., Nordness, P. N., Nelson, J. R., Knobel, M. L., Epstein, A.,…Epstein, M. H. (2002). "The…

The Logistics of Civil Affairs and Military Governments: The US experience 1939-1949

DTIC Science & Technology

1990-09-01

The first concentration camp reached by the US was at Ohrdruf-Nord, which was a work camp for the Buchenwald concentration camp (65:231). Eisenhower’s... Buchenwald over 50,000 had died at a rate of 200 per day. Sadly, Buchenwald was not the worst. At the extermination camps like Auschwitz up to 12,000 human

Using Direct Observation to Assist in Eligibility Decisions and Intervention Planning: The Scales for Assessing Emotional Disturbance-2 Observation Form

ERIC Educational Resources Information Center

Nordness, Philip D.; Epstein, Michael H.; Cullinan, Douglas

2013-01-01

A key issue in using the federal definition of emotional disturbance (ED) is the challenge of measuring five characteristics of ED (Epstein, Nordness, Cullinan, & Hertzog, 2002). Stated briefly, these five characteristics include: (1) an inability to learn; (2) relationship problems; (3) inappropriate behavior; (4) unhappiness or depression;…

Jobbik: A Better Hungary at the Cost of Europe

DTIC Science & Technology

2014-03-01

respect seemingly just out of reach, Hungary sublimated the frustrations of the age into increasing tensions between the anti-Enlightenment but pro ...the land via farms and mines. Thus, Jews were more 33 Silber, “Entrance of Jews into Hungarian... pro -capitalist policy norms established by other parties with similarly educated constituencies. Italy’s Lega Nord and Austria’s Freedom Party (FPÖ

Northern Scientific Training Program: Annual Report, 1999-2000 = Programme de formation scientifique dans le Nord: Rapport annuel, 1999-2000.

ERIC Educational Resources Information Center

Department of Indian Affairs and Northern Development, Ottawa (Ontario).

The Northern Scientific Training Program (NSTP) is managed by the Department of Indian Affairs and Northern Development as part of its mandate to foster science and technology in the Canadian North. NSTP supports Canadian universities in providing training that gives advanced and graduate students the opportunity to gain professional experience in…

Non-random mating and convergence over time for alcohol consumption, smoking, and exercise: the Nord-Trøndelag Health Study.

PubMed

Ask, Helga; Rognmo, Kamilla; Torvik, Fartein Ask; Røysamb, Espen; Tambs, Kristian

2012-05-01

Spouses tend to have similar lifestyles. We explored the degree to which spouse similarity in alcohol use, smoking, and physical exercise is caused by non-random mating or convergence. We used data collected for the Nord-Trøndelag Health Study from 1984 to 1986 and prospective registry information about when and with whom people entered marriage/cohabitation between 1970 and 2000. Our sample included 19,599 married/cohabitating couples and 1,551 future couples that were to marry/cohabitate in the 14-16 years following data collection. All couples were grouped according to the duration between data collection and entering into marriage/cohabitation. Age-adjusted polychoric spouse correlations were used as the dependent variables in non-linear segmented regression analysis; the independent variable was time. The results indicate that spouse concordance in lifestyle is due to both non-random mating and convergence. Non-random mating appeared to be strongest for smoking. Convergence in alcohol use and smoking was evident during the period prior to marriage/cohabitation, whereas convergence in exercise was evident throughout life. Reduced spouse similarity in smoking with relationship duration may reflect secular trends.

Geology and recognition criteria for uranium deposits of the quartz-pebble conglomerate type. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Button, A.; Adams, S.S.

1981-03-01

This report is concerned with Precambrian uraniferous conglomerates. This class of deposit has been estimated to contain between approximately 16 and 35 percent of the global uranium reserve in two rather small areas, one in Canada, the other in South Africa. Similar conglomerates, which are often gold-bearing, are, however, rather widespread, being found in parts of most Precambrian shield areas. Data have been synthesized on the geologic habitat and character of this deposit type. The primary objective has been to provide the most relevant geologic observations in a structural fashion to allow resource studies and exploration to focus on themore » most prospective targets in the shortest possible time.« less

Metallographic Characterization of Wrought Depleted Uranium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forsyth, Robert Thomas; Hill, Mary Ann

Metallographic characterization was performed on wrought depleted uranium (DU) samples taken from the longitudinal and transverse orientations from specific locations on two specimens. Characterization of the samples included general microstructure, inclusion analysis, grain size analysis, and microhardness testing. Comparisons of the characterization results were made to determine any differences based on specimen, sample orientation, or sample location. In addition, the characterization results for the wrought DU samples were also compared with data obtained from the metallographic characterization of cast DU samples previously characterized. No differences were observed in microstructure, inclusion size, morphology, and distribution, or grain size in regard tomore » specimen, location, or orientation for the wrought depleted uranium samples. However, a small difference was observed in average hardness with regard to orientation at the same locations within the same specimen. The longitudinal samples were slightly harder than the transverse samples from the same location of the same specimen. This was true for both wrought DU specimens. Comparing the wrought DU sample data with the previously characterized cast DU sample data, distinct differences in microstructure, inclusion size, morphology and distribution, grain size, and microhardness were observed. As expected, the microstructure of the wrought DU samples consisted of small recrystallized grains which were uniform, randomly oriented, and equiaxed with minimal twinning observed in only a few grains. In contrast, the cast DU microstructure consisted of large irregularly shaped grains with extensive twinning observed in most grains. Inclusions in the wrought DU samples were elongated, broken and cracked and light and dark phases were observed in some inclusions. The mean inclusion area percentage for the wrought DU samples ranged from 0.08% to 0.34% and the average density from all wrought DU samples was 1.62E+04/cm 2. Inclusions in the cast DU samples were equiaxed and intact with light and dark phases observed in some inclusions. The mean inclusion area percentage for the cast DU samples ranged from 0.93% to 1.00% and the average density from all wrought DU samples was 2.83E+04/cm 2. The average mean grain area from all wrought DU samples was 141 μm 2 while the average mean grain area from all cast DU samples was 1.7 mm2. The average Knoop microhardness from all wrought DU samples was 215 HK and the average Knoop microhardness from all cast DU samples was 264 HK.« less

The International Science and Politics of Depleted Uranium (Briefing charts)

DTIC Science & Technology

2010-11-01

lied before …” • Cite each other’s websites • Uniqueness: “DU + Anthrax Vaccine + Diet Soda + Flea Collars + Stress = Gulf War Illness • Demand proving...Activist Quotes • “DU was used in Iraq, Soldiers were in Iraq, Soldiers are sick, DU made the soldiers sick” • “DU is more dangerous than natural uranium...1 atom of DU will kill you” • “DU is more dangerous the further you are from the source” • “Depleted uranium is nuclear waste” • “U.S. is using

Connaissances des médecins généralistes de Mohammedia (Maroc) concernant le dépistage du cancer du sein

PubMed Central

Zine, Karima; Nani, Samira; Lahmadi, Imad Ait; Maaroufi, Abderrahmane

2016-01-01

Introduction Le cancer du sein représente un problème de santé publique majeur au Maroc. C'est le premier cancer chez la femme. L'objectif de ce travail était d'évaluer les connaissances des médecins généralistes (MG) en matière de dépistage du cancer du sein dans la préfecture de Mohammedia Maroc. Méthodes Nous avons mené une étude transversale, descriptive, exhaustive incluant les 97 MG exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Mohammedia. Résultats Le taux de participation était de 87%. L'âge moyen des MG était de 49,6 ± 8,1. Quatre-vingt pour cent (n=55) des MG ont donné une incidence incorrecte, 77,6% (n=85) ont reconnu l'existence d'un plan national de prévention et de contrôle du cancer (PNPCC) au Maroc, et 67,1 des MG ont rapporté l'existence d'un registre du cancer au Maroc. Le secteur d'activité était associé significativement avec les connaissances des MG sur le PNPCC et sur l'existence d'un guide de détection précoce du cancer du sein avec respectivement (p=0,003 et p=0,001). Une association significative entre l'ancienneté et l'existence d'un guide de détection précoce du cancer du sein et d'un registre du cancer du sein a été retrouvée avec (respectivement p=0,005 et p=0.002). Conclusion À la lumière de ces résultats il faudra renforcer les connaissances et les pratiques des MG par la promotion de la formation initiale et continue sur le dépistage. PMID:27800098

Depleted and natural uranium: chemistry and toxicological effects.

PubMed

Craft, Elena; Abu-Qare, Aquel; Flaherty, Meghan; Garofolo, Melissa; Rincavage, Heather; Abou-Donia, Mohamed

2004-01-01

Depleted uranium (DU) is a by-product from the chemical enrichment of naturally occurring uranium. Natural uranium is comprised of three radioactive isotopes: (238)U, (235)U, and (234)U. This enrichment process reduces the radioactivity of DU to roughly 30% of that of natural uranium. Nonmilitary uses of DU include counterweights in airplanes, shields against radiation in medical radiotherapy units and transport of radioactive isotopes. DU has also been used during wartime in heavy tank armor, armor-piercing bullets, and missiles, due to its desirable chemical properties coupled with its decreased radioactivity. DU weapons are used unreservedly by the armed forces. Chemically and toxicologically, DU behaves similarly to natural uranium metal. Although the effects of DU on human health are not easily discerned, they may be produced by both its chemical and radiological properties. DU can be toxic to many bodily systems, as presented in this review. Most importantly, normal functioning of the kidney, brain, liver, and heart can be affected by DU exposure. Numerous other systems can also be affected by DU exposure, and these are also reviewed. Despite the prevalence of DU usage in many applications, limited data exist regarding the toxicological consequences on human health. This review focuses on the chemistry, pharmacokinetics, and toxicological effects of depleted and natural uranium on several systems in the mammalian body. A section on risk assessment concludes the review.

Ghrelin protects against depleted uranium-induced apoptosis of MC3T3-E1 cells through oxidative stress-mediated p38-mitogen-activated protein kinase pathway

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hao, Yuhui; Liu, Cong; Huang, Jiawei

Depleted uranium (DU) mainly accumulates in the bone over the long term. Osteoblast cells are responsible for the formation of bone, and they are sensitive to DU damage. However, studies investigating methods of reducing DU damage in osteoblasts are rarely reported. Ghrelin is a stomach hormone that stimulates growth hormones released from the hypothalamic–pituitary axis, and it is believed to play an important physiological role in bone metabolism. This study evaluates the impact of ghrelin on DU-induced apoptosis of the osteoblast MC3T3-E1 and investigates its underlying mechanisms. The results show that ghrelin relieved the intracellular oxidative stress induced by DU,more » eliminated reactive oxygen species (ROS) and reduced lipid peroxidation by increasing intracellular GSH levels; in addition, ghrelin effectively suppressed apoptosis, enhanced mitochondrial membrane potential, and inhibited cytochrome c release and caspase-3 activation after DU exposure. Moreover, ghrelin significantly reduced the expression of DU-induced phosphorylated p38-mitogen-activated protein kinase (MAPK). A specific inhibitor (SB203580) or specific siRNA of p38-MAPK could significantly suppress DU-induced apoptosis and related signals, whereas ROS production was not affected. In addition, ghrelin receptor inhibition could reduce the anti-apoptosis effect of ghrelin on DU and reverse the effect of ghrelin on intracellular ROS and p38-MAPK after DU exposure. These results suggest that ghrelin can suppress DU-induced apoptosis of MC3T3-E1 cells, reduce DU-induced oxidative stress by interacting with its receptor, and inhibit downstream p38-MAPK activation, thereby suppressing the mitochondrial-dependent apoptosis pathway. - Highlights: • Ghrelin suppressed DU-induced apoptosis of MC3T3-E1 cells. • Ghrelin inhibited DU-induced oxidative stress and further p38-MAPK activation. • Ghrelin further suppressed mitochondrial-dependent apoptosis pathway. • The anti-oxidation effect of ghrelin was regulated through its receptor. • Ghrelin has the potential for use in drug therapies for DU poisoning.« less

Depleted and enriched uranium exposure quantified in former factory workers and local residents of NL Industries, Colonie, NY USA.

PubMed

Arnason, John G; Pellegri, Christine N; Moore, June L; Lewis-Michl, Elizabeth L; Parsons, Patrick J

2016-10-01

Between 1958 and 1982, NL Industries manufactured components of enriched (EU) and depleted uranium (DU) at a factory in Colonie NY, USA. More than 5 metric tons of DU was deposited as microscopic DU oxide particles on the plant site and surrounding residential community. A prior study involving a small number of individuals (n=23) indicated some residents were exposed to DU and former workers to both DU and EU, most probably through inhalation of aerosol particles. Our aim was to measure total uranium [U] and the uranium isotope ratios: (234)U/(238)U; (235)U/(238)U; and (236)U/(238)U, in the urine of a cohort of former workers and nearby residents of the NLI factory, to characterize individual exposure to natural uranium (NU), DU, and EU more than 3 decades after production ceased. We conducted a biomonitoring study in a larger cohort of 32 former workers and 99 residents, who may have been exposed during its period of operation, by measuring Total U, NU, DU, and EU in urine using Sector Field Inductively Coupled Plasma - Mass Spectrometry (SF-ICP-MS). Among workers, 84% were exposed to DU, 9% to EU and DU, and 6% to natural uranium (NU) only. For those exposed to DU, urinary isotopic and [U] compositions result from binary mixing of NU and the DU plant feedstock. Among residents, 8% show evidence of DU exposure, whereas none shows evidence of EU exposure. For residents, the [U] geometric mean is significantly below the value reported for NHANES. There is no significant difference in [U] between exposed and unexposed residents, suggesting that [U] alone is not a reliable indicator of exposure to DU in this group. Ninety four percent of workers tested showed evidence of exposure to DU, EU or both, and were still excreting DU and EU decades after leaving the workforce. The study demonstrates the advantage of measuring multiple isotopic ratios (e.g., (236)U/(238)U and (235)U/(238)U) over a single ratio ((235)U/(238)U) in determining sources of uranium exposure. Copyright © 2016 Elsevier Inc. All rights reserved.

Hydrogeology of a fractured shale (Opalinus Clay): Implications for deep geological disposal of radioactive wastes

NASA Astrophysics Data System (ADS)

Gautschi, Andreas

2001-01-01

As part of the Swiss programme for high-level radioactive-waste disposal, a Jurassic shale (Opalinus Clay) is being investigated as a potential host rock. Observations in clay pits and the results of a German research programme focusing on hazardous waste disposal have demonstrated that, at depths of 10-30 m, the permeability of the Opalinus Clay decreases by several orders of magnitude. Hydraulic tests in deeper boreholes (test intervals below 300 m) yielded hydraulic conductivities <10-12 m/s, even though joints and faults were included in some of the test intervals. These measurements are consistent with hydrogeological data from Opalinus Clay sections in ten tunnels in the Folded Jura of northern Switzerland. Despite extensive faulting, only a few indications of minor water inflow were encountered in more than 6,600 m of tunnel. All inflows were in tunnel sections where the overburden is less than 200 m. The hydraulic data are consistent with clay pore-water hydrochemical and isotopic data. The extensive hydrogeological data base - part of which derives from particularly unfavourable geological environments - provides arguments that advective transport through faults and joints is not a critical issue for the suitability of Opalinus Clay as a host rock for deep geological waste disposal. Résumé. Dans le cadre du programme suisse de stockage de déchets hautement radioactifs, une formation argileuse du Jurassique, l'argile à Opalinus, a été étudiée en tant que roche hôte potentielle. Des observations dans des cavités dans l'argile et les résultats du programme de recherche allemand consacré au stockage de déchets à risques ont démontré que, à des profondeur de 10 à 30 m, la perméabilité des argiles à Opalinus décroît de plusieurs ordres de grandeur. Des essais hydrauliques dans des forages plus profonds (intervalles de test á une profondeur de plus de 300 m) ont donné des conductivités hydrauliques inférieures à 10-12 m/s, même lorsque des fractures et des failles existaient dans certains des intervalles d'essais. Ces mesures sont conformes aux données hydrogéologiques tirées du recoupement des argiles à Opalinus par dix tunnels du Jura plissé du nord de la Suisse. Malgré une tectonique intense, peu de manifestations de faibles venues d'eau ont été rencontrées dans plus de 6600 m de tunnel. Toutes les venues d'eau se sont produites dans des sections de tunnel où le recouvrement est inférieur à 200 m. Les données hydrauliques sont en bon accord avec les données hydrochimiques et isotopiques de l'eau porale des argiles. En se basant sur le grand nombre de données hydrogéologiques, qui portent en partie sur les environnements géologiques particulièrement peu propices, on peut avancer que le transport advectif le long des failles et des fractures n'est pas un facteur susceptible de remettre en question le choix de l'argile à Opalinus comme roche hôte pour le stockage de déchets radioactifs en formation géologique profonde. Resúmen. Dentro del programa suizo de eliminación de residuos radiactivos de alta actividad, se está investigando la posibilidad de utilizar unos esquistos Jurásicos (Arcilla Opalina) como depósito geológico. Las observaciones efectuadas en pozos en arcilla y los resultados de un programa de estudio alemán sobre eliminación de residuos peligrosos han demostrado que, a profundidades de entre 10 y 30 m, la permeabilidad de la Arcilla Opalina decrece en varios órdenes de magnitud. Los ensayos hidráulicos realizados en sondeos más profundos (en intervalos situados a más de 300 m) proporcionaron conductividades hidráulicas inferiores a 10-12 m/s, pese a que algunos de los intervalos interceptaban juntas y fallas. Estas medidas son coherentes con los datos hidrogeológicos de las secciones de Arcilla Opalina existentes en 10 túneles del Jurásico Plegado, al norte de Suiza. A pesar de las fallas extensivas, apenas se hallaron indicios de entrada de agua en los más de 6.600 m de túnel. Todos los flujos tenían lugar en secciones del túnel que soportan sobrecargas inferiores a 200 m. Los datos hidráulicos son coherentes con los datos hidroquímicos e isotópicos del agua intersticial de las arcillas. Los abundantes datos hidrogeológicos -parte de los cuales proceden de medios particularmente desfavorables desde el punto de vista geológico- proporcionan argumentos de que el transporte advectivo a través de fallas y juntas no es un aspecto crítico en lo que respecta a la idoneidad de la Arcilla Opalina como almacenamiento geológico profundo de residuos.

Exploration of an alluvial aquifer in Oman by time-domain electromagnetic sounding

NASA Astrophysics Data System (ADS)

Young, M. E.; de Bruijn, R. G. M.; Al-Ismaily, A. Salim

One-third of the population of Oman depends upon groundwater extracted from the alluvium of the Batinah Plain, on the coast of the Gulf of Oman. Deep geophysical exploration techniques were used to determine the depth and nature of the alluvium and the boundaries of the aquifer. The base and structural controls of the alluvial basin at its contact with Tertiary marine sediments and Cretaceous ophiolite were mapped with seismic reflection data, recorded originally for oil exploration. The base of the alluvium dips northward from the foothills of the Northern Oman Mountains, reaching a maximum depth of 2000m at the coast. The varying facies of the alluvium are grossly characterised by different, overlapping ranges of electrical resistivity, depending largely on the clay content and degree of cementation. Resistivities near the coast are reduced by saline intrusion. These variations of resistivity were mapped with time-domain electromagnetic sounding along 400km of profile, to distinguish among the three zones of the alluvial aquifer. The wedge of saline intrusion was also delineated, up to 10km from the coast. The thickness of the saturated gravel aquifer ranges from 20-160m in an area greater than 600km2. Résumé Un tiers de la population d'Oman est alimenté par de l'eau souterraine pompée dans les alluvions de la plaine de Batinah, sur la côte du golfe d'Oman. Des techniques d'exploration géophysique profonde ont été mises en oeuvre pour déterminer la profondeur et la nature des alluvions et les limites de l'aquifère. La base et les contrôles structuraux du bassin alluvial au contact des sédiments marins tertiaires et des ophiolites crétacées ont été cartographiés à partir des données de sismique réflexion obtenues à l'origine pour la recherche pétrolière. La base des alluvions plonge vers le nord à partir du piémont du massif septentrional d'Oman, pour atteindre une profondeur maximale de 2000m sur la côte. Les divers faciès alluviaux sont grossièrement caractérisés par des différentes gammes de résistivitéélectrique se recouvrant, dépendant surtout de la teneur en argiles et du degré de cimentation. Les résistivités près de la côte diminuent du fait de l'intrusion marine. Ces variations de résistivité ont été cartographiées à partir de 400km de profils électromagnétiques, dans le domaine temporel ; trois zones ont été distinguées dans l'aquifère alluvial. Le biseau salé a aussi été délimité, jusqu'à 10km de la côte. L'épaisseur de la partie saturée des graviers va de 20-160m sur une étendue supérieure à 600km2. Resumen Un tercio de la población de Omán depende de las aguas subterráneas extraídas del aluvial de la Llanura de Batinah, en la costa del Golfo de Omán. Para determinar la profundidad y naturaleza del aluvial, así como los límites del acuífero, se han usado técnicas de exploración geofísica profunda. El basamento y los límites estructurales del aluvial en su contacto con los sedimentos marinos del Terciario y la ofiolita cretácica se obtuvieron mediante sísmica de reflexión, registrada previamente en campañas de exploración petrolífera. La base del aluvial buza hacia el norte desde el pie de las Montañas del Norte de Omán, alcanzando una profundidad máxima de 2000m en la costa. Las distintas facies del aluvial están caracterizadas por rangos distintos, pero superpuestos, de resistividad eléctrica, dependiendo del contenido en arcillas y del grado de cementación. Las resistividades cerca de la costa se reducen por la intrusión salina. Estas variaciones de resistividad se obtuvieron con registros electromagnéticos a lo largo de un perfil de 400km, con el objetivo de distinguir las tres zonas del acuífero aluvial. También se pudo obtener la geometría de la cuña de intrusión, que llega hasta 10km de la costa. El espesor de las gravas saturadas que forman el acuífero oscila entre los 20-160m en un área superior a 600km2.

The deep Algerian margin structure revisited by the Algerian-French SPIRAL research program, stage 2 : Wide-ange seismic experiment

NASA Astrophysics Data System (ADS)

Klingelhoefer, Frauke; Yellès, Abdelkarim; Bracène, Rabah; Graindorge, David; Ouabadi, Aziouz; Schnürle, Philippe; Scientific Party, Spiral

2010-05-01

During the second leg of the Algerien - French SPIRAL (Sismique Profonde et Investigation Regionale du Nord de l'ALgerie) cruise conducted on the R/V Atalante in October and November 2009 an extensive wide-angle seismic data-set was acquired on 5 regional transects off Algeria, from Arzew bay to the west, to Annaba to the east. The profiles are between 80 and 180 km in length and around 40 ocean-bottom seismometers were deployed on each profile. A 8350 cu. inch tuned airgun array consisting of 10 Bolt airguns was used to generate of deep frequency to allow for a good penetration. All profiles were extended on land up to 150 km by land-stations to better constrain the structure of the margin and the nature of the ocean-continent transition zone. Coincident reflection seismic, gravity and magnetic data were acquired on all profiles during the first leg of the cruise. The resulting data quality is very good with deep penetrating arrivals on most of the instruments. Only on very few instruments a deep salt layer inhibits deeper penetration of the seismic energy. Two instruments were lost and all other yielded useful information on geophone and hydrophone channels. Instruments located close to the coast show arrivals from thick sedimentary layers. Instruments located on oceanic crust indicate a relatively thin crust overlying a mantle layer characterised by seismic velocities of 8 km/s. Forward and inverse modelling of the wide-angle seismic data will help constrain the deep structure of the margin, the nature of the crust and might help to constrain possible existence of a detached slab in the upper mantle. Integration of the wide-angle seismic data with multichannel seismic, gravity and magnetic data will enable us to better understand the tectonic history and the structure of the Algerian margin.

First images of the crustal structure across the eastern Algerian margin, from deep penetrating seismic data.

NASA Astrophysics Data System (ADS)

Bouyahiaoui, Boualem; Abtout, Abdeslam; Sage, Françoise; Klingelhoeffer, Frauke; Collot, Jean-yves; Yelles-chaouche, Abdelkarim; Marok, Abbas; Djellit, Hamou; Galves, Audrey; Bracène, Rabah; Schnurle, Philippe; Graindorge, David; party, Scientific

2013-04-01

The Algerian continental margin North Africa presents one of only a few examples of a passive continental margin formed in a back-arc environment, which undergoes current compression and is proposed to be reactivated today. In the framework of the Algerian - French SPIRAL research program (Sismique Profonde et Investigation Regionale du nord de l'ALgérie), a seismic cruise was conducted on the R/V Atalante from September to November 2009. During the cruise, deep penetrating low frequency multichannel and wide-angle seismic data were acquired in order to study the deep structure of the Algerian margin. In this work, we present the preliminary results from wide-angle modeling of the North-east Algerian margin in the region of Annaba along a N-S transect using a data set of 42 OBS (ocean bottom seismometers) along a profile extending 117km, and 13 broadband seismological stations along a profile of 80 km length. Travel-time tomography and forward modeling were undertaken to model the velocity structure in this region. The resulting velocity models image the thickness of the sedimentary layers, which varies between a few hundred meters on the continental margin of more than 4 km in the basin. The crust is about 6 km thick in the basin, and thickens to 7-8 km between 40 and 60km distance from the margin toe. Crustal thickness increases to about 22 km at the continental slope over a distance of ~ 90 km. The nature of the crust was determined to be thin oceanic with abnormal velocity gradient in the basin, and thinned continental from around 30 km distance from the coast landward. Integration of the wide-angle seismic data with multichannel seismic, gravity and magnetic data will help to better understand the structure of the Algerian margin and the adjacent oceanic basin in the Annaba region, and to discuss the numerous cinematic models proposed in literature regarding the formation of the north-Algerian basin.

Groundwater for urban water supplies in northern China - An overview

NASA Astrophysics Data System (ADS)

Zaisheng, Han

Groundwater plays an important role for urban and industrial water supply in northern China. More than 1000 groundwater wellfields have been explored and installed. Groundwater provides about half the total quantity of the urban water supply. Complete regulations and methods for the exploration of groundwater have been established in the P.R. China. Substantial over-exploitation of groundwater has created environmental problems in some cities. Some safeguarding measures for groundwater-resource protection have been undertaken. Résumé Les eaux souterraines jouent un rôle important dans l'approvisionnement en eau des agglomérations et des industries du nord de la Chine. Les explorations ont conduit à mettre en place plus de 1000 champs de puits captant des eaux souterraines. Les eaux souterraines satisfont environ la moitié des besoins en eau des villes. Une réglementation complète et des méthodes d'exploration des eaux souterraines ont étéétablies en République Populaire de Chine. Une surexploitation très nette est à l'origine de problèmes environnementaux dans certaines villes. Des mesures ont été prises pour protéger la ressource en eau souterraine. Resumen El agua subterránea desempeña un papel importante en el suministro de agua para uso doméstico e industrial en la China septentrional. Se han explorado y puesto en marcha más de 1000 campos de explotación de aguas subterráneas, que proporcionan cerca de la mitad del total del suministro urbano. En la República Popular de China se han definido totalmente la legislación y la metodología para realizar estas explotaciones. La gran sobreexplotación en algunas ciudades ha creado algunos problemas medioambientales. Como consecuencia, se han llevado a cabo algunas medidas de protección de los recursos de aguas subterráneas.

Depleted and enriched uranium exposure quantified in former factory workers and local residents of NL Industries, Colonie, NY USA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnason, John G.

Background: Between 1958 and 1982, NL Industries manufactured components of enriched (EU) and depleted uranium (DU) at a factory in Colonie NY, USA. More than 5 metric tons of DU was deposited as microscopic DU oxide particles on the plant site and surrounding residential community. A prior study involving a small number of individuals (n=23) indicated some residents were exposed to DU and former workers to both DU and EU, most probably through inhalation of aerosol particles. Objectives: Our aim was to measure total uranium [U] and the uranium isotope ratios: {sup 234}U/{sup 238}U; {sup 235}U/{sup 238}U; and {sup 236}U/{supmore » 238}U, in the urine of a cohort of former workers and nearby residents of the NLI factory, to characterize individual exposure to natural uranium (NU), DU, and EU more than 3 decades after production ceased. Methods: We conducted a biomonitoring study in a larger cohort of 32 former workers and 99 residents, who may have been exposed during its period of operation, by measuring Total U, NU, DU, and EU in urine using Sector Field Inductively Coupled Plasma - Mass Spectrometry (SF-ICP-MS). Results: Among workers, 84% were exposed to DU, 9% to EU and DU, and 6% to natural uranium (NU) only. For those exposed to DU, urinary isotopic and [U] compositions result from binary mixing of NU and the DU plant feedstock. Among residents, 8% show evidence of DU exposure, whereas none shows evidence of EU exposure. For residents, the [U] geometric mean is significantly below the value reported for NHANES. There is no significant difference in [U] between exposed and unexposed residents, suggesting that [U] alone is not a reliable indicator of exposure to DU in this group. Conclusions: Ninety four percent of workers tested showed evidence of exposure to DU, EU or both, and were still excreting DU and EU decades after leaving the workforce. The study demonstrates the advantage of measuring multiple isotopic ratios (e.g., {sup 236}U/{sup 238}U and {sup 235}U/{sup 238}U) over a single ratio ({sup 235}U/{sup 238}U) in determining sources of uranium exposure. - Highlights: • Biomonitoring study of residents and former workers exposed to DU in Colonie NY. • Urine (99 residents+32 former workers) analyzed for depleted uranium (DU). • DU detected in 84% of workers and 8% of residents >30 years after plant closed. • Enriched uranium detected in 6% of former workers based on isotope ratios.« less

Neurogenic Causes of Detrusor Underactivity

PubMed Central

Kadow, Brian T.; Tyagi, Pradeep; Chermansky, Christopher J.

2015-01-01

Detrusor underactivity (DU) is a poorly understood dysfunction of the lower urinary tract which arises from multiple etiologies. Symptoms of DU are non-specific, and a pressure-flow urodynamic study is necessary to differentiate DU from other conditions such as overactive bladder (OAB) or bladder outlet obstruction (BOO). The prevalence of DU ranges from 10–48%, and DU is most prevalent in elderly males. The pathophysiology underlying DU can be from both neurogenic and non-neurogenic causes. In this article, we review the neurogenic causes of detrusor underactivity, including diabetic bladder dysfunction, spinal cord injury, multiple sclerosis, Parkinson’s disease, cerebrovascular accident, traumatic brain injury, and Fowler’s syndrome. As knowledge about the underlying causes of DU advances, there have been several potential therapeutic approaches proposed to help those who suffer from this condition. PMID:26715948

Rupture simultanée du ligament croisé antérieur et du ligament patellaire: à propos d'un cas

PubMed Central

Achkoun, Abdessalam; Houjairi, Khalid; Quahtan, Omar; Hassoun, Jalal; Arssi, Mohamed; Rahmi, Mohamed; Garch, Abdelhak

2016-01-01

La rupture simultanée du tendon rotulien et du ligament croisé antérieur est une lésion relativement rare. Son diagnostic peut facilement manquer lors de l'examen initial. Les options de traitement incluent la réparation immédiate du tendon rotulien avec soit la reconstruction simultanée ou différée de ligament croisé antérieur. Nous rapportons le cas d'une rupture combinée du tendon rotulien et du ligament croisé antérieur chez un jeune footballeur de 22 ans. Une approche de traitement en deux temps a été effectuée avec un excellent résultat fonctionnel. PMID:27366288

Architecting for Sustainable Software Delivery

DTIC Science & Technology

2012-06-01

14 CrossTalk—May/June 2012 RAPID AND AGILE STABILITY Architecting for Sustainable Software Delivery Ronald J. Koontz , Boeing Robert L. Nord...Figure 2, and additional architecture documentation can be found in the work of Koontz [9, 10, 11]. Designing for extensibility promotes continued...Mapping of Practices to Agile and Architecture Criteria CrossTalk—May/June 2012 19 RAPID AND AGILE STABILITY ABOUT THE AUTHORS Ronald J. Koontz

Sweet resin bush on the Santa Rita Experimental Range: An eradication effort

Treesearch

Larry D. Howery; Bruce D. Munda; Dan G. Robinett; Harry H. Buck

2003-01-01

Sweet resin bush (Euryops subcarnosus DC ssp. vulgaris B. Nord; or, Euryops multifidis (L. f.) DC.), a South African shrub introduced to Arizona in the 1930s, was discovered on the Santa Rita Experimental Range (SRER) in 1998. Due to the threat of spread of this invasive plant and its potential to cause adverse environmental and economic effects, and because it posed a...

Proceedings of the Second Software Architecture Technology User Network (SATURN) Workshop

DTIC Science & Technology

2006-08-01

Proceedings of the Second Software Architecture Technology User Network (SATURN) Workshop Robert L. Nord August 2006 TECHNICAL REPORT CMU...SEI-2006-TR-010 ESC-TR-2006-010 Software Architecture Technology Initiative Unlimited distribution subject to the copyright. This report was...Participants 3 3 Presentations 5 3.1 SATURN Opening Presentation: Future Directions of the Software Architecture Technology Initiative 5 3.2 Keynote

^1H NMR studies of the diamagnetic gallium (III) and paramagnetic iron (III) complexes of a chiral macrobicyclic ligand of bicapped tris (binaphtol) type

NASA Astrophysics Data System (ADS)

Baret, P.; Beaujolais, V.; Bougault, C.; Gaude, D.; Pierre, J.-L.

1998-01-01

^1H NMR studies of the diamagnetic gallium (III) and paramagnetic iron (III) complexes of a chiral macrobicyclic ligand of bicapped tris (binaphtol) type are described. The study of the gallium complex emphasizes: (i) that the inversion of the octahedral center is not observed and: (ii) the absence of exchange between free ligand and complex, at room temperature. In the case of the iron complex, assignments of the hyperfine shifted resolved resonances are achieved, based on temperature-behavior studies, which evidence the D3 symmetry of the complex. These assignments are in complete agreement with measured T1 values and proton-to-iron distances obtained from molecular modelling. Les complexes du gallium (III) et du fer (III) d'un ligand macrobicyclique chiral impliquant trois sous-unités de type binaphtol sont étudiés en RMN du proton en solution méthanolique. L'étude du complexe (diamagnétique) du gallium permet de montrer que le complexe : (i) ne subit pas d'inversion de la configuration (Δ/Λ) du site octaédrique et : (ii) qu'il n'y a pas d'échange entre ligand libre et complexe à la température ambiante. L'évolution du spectre du complexe paramagnétique du fer avec la température permet une attribution des protons du ligand et met en évidence la symétrie D3 du complexe. Une bonne corrélation est obtenue entre la distance fer-proton (donnée par la modélisation moléculaire) et le T1 du proton considéré.

Source tracing of fluvial suspended sediments by magnetic and geochemical particle characterization: example of the Canche watershed (Nord-Pas-de-Calais, France)

NASA Astrophysics Data System (ADS)

Patault, Edouard; Alary, Claire; Franke, Christine; Gauthier, Arnaud; Abriak, Nor-Edine

2016-04-01

In France, erosion by water run-off is estimated to 1.5 t ha-1yr-1 and can exceed 10 t ha-1yr-1 in large growing areas, such as the North of France (Nord-Pas-de-Calais). In this region, the Canche watershed (1294 km2) sustains heavy loss of fertile soils. The land use is mainly dominated by arable lands (80%) and in 2013, 104 kt of suspended sediment transited to the estuary. As demonstrated in literature, agricultural soil erosion leads to the gradual disappearance and depletion of fertile soil, which constitute a non-renewable resource at human time scale. Additionally, water erosion can significantly damage the aquatic habitat and can be responsible for the input of nutrients, bacteria, pesticides, heavy metals and radionuclides into surface waters. Conscious of these effects, many programs have emerged in the Nord-Pas-de-Calais to reduce erosion. This study presents a combination of environmental magnetic proxy parameters and geochemical analyses on sediments and suspended particulate matter. The aim is to develop effective tools to trace erosion by water run-off and quantify this process. In order to identify the respective sediment sources in the Canche watershed, sediment trap samples of suspended particulate matter were recovered at key positions along the Canche watershed. The preliminary results show that magnetic concentration (Mrs) shows typical values for the agricultural soils in the region, but these variations in magnetic concentrations and total irons concentrations are not always correlated, which may be explained by the iron speciation. In calculating the so-called S-ratio for each sample we can distinguish changes in magneto-mineralogy (and thus iron speciation) from magnetite-dominated assemblages in the mainstream Canche (naturel background signal) to high-coercivity-dominated assemblages in the tributaries, typical for soil erosion material rich in hematite/goethite. In combination with the element concentrations from ICP analyses, this proxy parameter may give valuable insight into the tracing of the suspended sediment sources. In perspective, the seasonal variability and the discharge in the Canche watershed have to be taken into account.

Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation

DTIC Science & Technology

2012-07-01

Std. Z39.18 Victoria Seewaldt, M.D. Dynamic Testing of Signal Transduction Deregulation During Breast Cancer Initiation Duke University Durham...attomole- zeptomole range. Internal dilution curves insure a high-dynamic calibration range. DU -26 8L DU -26 6L DU -29 5R DU -22 9.2 L DU...3: Nanobiosensor technology is translated to test for pathway deregulation in RPFNA cytology obtained from 10 high-risk women with cytological

Hazardous Waste Cleanup: E.I. DuPont de Nemours & Company in Pompton Lakes, New Jersey

EPA Pesticide Factsheets

E.I. DuPont De Nemours & Company is located at 2000 Cannonball Road, Pompton Lakes, New Jersey. The DuPont Pompton Lakes Works site (DuPont) occupies approximately 570 acres of land in Pompton Lakes and Wanaque.

Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hao, Yuhui; Huang, Jiawei; Gu, Ying

Depleted uranium (DU) has been widely used in both civilian and military activities, and the kidney is the main target organ of DU during acute high-dose exposures. In this study, the nephrotoxicity caused by DU in metallothionein-1/2-null mice (MT −/−) and corresponding wild-type (MT +/+) mice was investigated to determine any associations with MT. Each MT −/− or MT +/+ mouse was pretreated with a single dose of DU (10 mg/kg, intraperitoneal injection) or an equivalent volume of saline. After 4 days of DU administration, kidney changes were assessed. After DU exposure, serum creatinine and serum urea nitrogen in MTmore » −/− mice significantly increased than in MT +/+ mice, with more severe kidney pathological damage. Moreover, catalase and superoxide dismutase (SOD) decreased, and generation of reactive oxygen species and malondialdehyde increased in MT −/− mice. The apoptosis rate in MT −/− mice significantly increased, with a significant increase in both Bax and caspase 3 and a decrease in Bcl-2. Furthermore, sodium-glucose cotransporter (SGLT) and sodium-phosphate cotransporter (NaPi-II) were significantly reduced after DU exposure, and the change of SGLT was more evident in MT −/− mice. Finally, exogenous MT was used to evaluate the correlation between kidney changes induced by DU and MT doses in MT −/− mice. The results showed that, the pathological damage and cell apoptosis decreased, and SOD and SGLT levels increased with increasing dose of MT. In conclusion, MT deficiency aggravated DU-induced nephrotoxicity, and the molecular mechanisms appeared to be related to the increased oxidative stress and apoptosis, and decreased SGLT expression. - Highlights: • MT −/− and MT +/+ mice were used to evaluate nephrotoxicity of DU. • Renal damage was more evident in the MT −/− mice after exposure to DU. • Exogenous MT also protects against DU-induced nephrotoxicity. • MT deficiency induced more ROS and apoptosis after exposure to DU. • MT deficiency down-regulated SGLT expression after exposure to DU.« less

Identification des objets et detection de leur alignement en utilisant la technologie RFID

NASA Astrophysics Data System (ADS)

Rahma, Zayoud

De nos jours, les vehicules motorises sont essentiels dans notre vie quotidienne, d'ou la necessite de leur approvisionnement en carburant. L'approvisionnement en carburant peut entrainer certains inconvenients, tels que: les files d'attente, la disponibilite non-continuelle du carburant et les fraudes. Les problemes d'attente et de disponibilite non-continuelle du carburant peuvent etre facilement resolus en allant a une autre station d'essence aux alentours si disponibles. Par contre le probleme de fraudes est plus difficile a resoudre. De ce fait, decoule notre solution qui consiste a developper un systeme intelligent pour la gestion d'approvisionnement en carburant afin de remedier a ce probleme de fraudes. Pour des raisons de surete, il faut eviter les risques d'etincelles dans l'environnement du carburant. En particulier, il convient de ne pas utiliser un systeme utilisant 1'electricite proche de la pompe, du tuyau ou du reservoir du carburant du vehicule. Nous avons choisi la technologie RFID (Radio Frequency IDentification) et avons opte pour l'utilisation des etiquettes passives, etant donne que les etiquettes semi-passives ou actives contiennent une batterie electrique et sont nettement plus cheres. Un vehicule motorise sera identifie avec une etiquette RFID passive collee au-dessus du goulot de son reservoir. Deux autres etiquettes RFID seront placees sur le pistolet de sorte que le flux du carburant ne sera autorise que lorsque les trois etiquettes sont alignees. Notre travail etait a la demande d'une entreprise petroliere ayant une chaine internationale de stations de carburant. Le travail consiste en la conception, par la recherche, du systeme requis et s'articule sur l'optimisation de la topologie des antennes et des etiquettes de sorte que le systeme juge qu'il y a alignement lorsque le bec du pistolet est fonce dans le goulot du reservoir, et par consequent autorise le versement du carburant. Dans tous les autres cas, le systeme doit juger qu'il n'y a pas alignement et par consequent le flux du carburant n'est pas autorise. Mots cles: RFID, identification, localisation, alignement, fraudes, station-service.

Selection for fertility in mice - the selection plateau and how to overcome it.

PubMed

Schüler, L

1985-04-01

A long-term experiment for increasing the traits first day litter size (LS1) and litter weight (LW1) was conducted with two populations for 33 generations. The selection plateau was reached in population DU-C (selection and estrus synchronization (h(2) = 0.02±0.01); in population DU-K (selection) the plateau (h(2) = 0.05±0.2) was nearly reached. Selection progress per generation was in LS1 b = 0.11±0.02; b = 0.12±0.04 (1st to 18th generation DU-K, DU-C) and b = 0.10±0.03; b = 0.07±0.05 (19th to 33rd generation, DU-K, DU-C) in LW1 b = 0.16±0.04 g; 0.19±0.07 g (DU-K, DU-C) b = 0.20±0.09 g; 0.001±0.09 g (DU-K, DU-C). Reverse and relaxe selection as well as systematic inbreeding was applied for 10 generations. Reverse selection yielded h(2) = 0.28±0.11 (R-DU-K) and h(2) = 0.17±0.05 (R-DU-C) and showed that there was still additive genetic variance. Relaxe selection did not cause alterations in the selection parameters, whereas inbreeding lead to inbred depressions (b = LS1 = -0.42±0.15; -0.45±0.12; b = LW1 = -1.13±0.20; -0.82±0.18 I-DU-K, I-DU-C). The plateau was based upon the heterozygote advantage. Several methods for overcoming the plateau were applied. A new selective useful variance could be created by crossing the plateau populations (h(2) = 0.14±0.04). A short-term progress in overcoming the plateau (1st to 3rd generation) could be obtained by litter size standardization (LS = 388). Tandem selection (selection for body weight - BW42) as well as crossing of inbred strains were not suitable for overcoming the selection plateau. Altering the environmental conditions as a possibility for overcoming the plateau has been discussed.

Prevalence of duck circovirus infection of subclinical pekin ducks in South Korea.

PubMed

Cha, Se-Yeoun; Song, Eu-Tteum; Kang, Min; Wei, Bai; Seo, Hye-Suk; Roh, Jae-Hee; Yoon, Ran-Hee; Moon, Oun-Kyoung; Jang, Hyung-Kwan

2014-04-01

An investigation was carried out to determine the prevalence and infection pattern of duck circovirus (DuCV) in subclinical Pekin ducks on South Korean duck farms. A total of 147 samples collected from 92 duck farms in five provinces were examined from 2011 to 2012. The overall prevalence of DuCV PCR-positive pooled bursa of Fabricius and liver samples was 21.8% (32/147). The prevalence of DuCV PCR-positive samples increased significantly in 3-week-old ducks compared with that in 1-week-old ducks (P<0.05). DuCV in association with Riemerella and Salmonella infections (10.9%; 16/147) occurred at the same level as infection with DuCV alone (10.9%; 16/147). In comparison of the relationship between bacterial diseases (salmonellosis, Riemerella infection) and morbidity in farms with and without DuCV, morbidity was higher in circovirus-positive farms (50%; 16/32) than in circovirus-negative farms (26.1%; 30/115). Our findings provide baseline information on the degree of DuCV infection and distribution and pattern of DuCV in ducks, and it is evident that DuCV can be associated with subclinical diseases and that subclinical infection could be economically important.

Acceptabilité du test VIH proposé aux nourrissons dans les services pédiatriques, en Côte d'Ivoire, Significations pour la couverture du diagnostic pédiatrique

PubMed Central

Oga, Maxime; Brou, Hermann; Dago-Akribi, Hortense; Coffie, Patrick; Amani-Bossé, Clarisse; Ékouévi, Didier; Yapo, Vincent; Menan, Hervé; Ndondoki, Camille; Timité-Konan, M.; Leroy, Valériane

2014-01-01

Résumé Problème: Le dépistage VIH chez les enfants a rarement été au centre des préoccupations des chercheurs. Quand le dépistage pédiatrique a retenu l'attention, cela a été pour éclairer seulement sur les performances diagnostiques en ignorant même que le test pédiatrique comme bien d'autres peut s'accepter ou se refuser. Cet article met au cœur de son analyse les raisons qui peuvent expliquer qu'on accepte ou qu'on refuse de faire dépister son enfant. Objectif: Etudier chez les parents, les mères, les facteurs explicatifs de l'acceptabilité du test VIH des nourrissons de moins de six mois. Méthodes: Entretien semi-directif à passages répétés avec les parents de nourrissons de moins de six mois dans les formations sanitaires pour la pesée/vaccination et les consultations pédiatriques avec proposition systématique d'un test VIH pour leur nourrisson. Résultats: Nous retenons que la réalisation effective du test pédiatrique du VIH chez le nourrisson repose sur trois éléments. Primo, le personnel de santé par son discours (qui dénote de ses connaissances et perceptions même sur l'infection) orienté vers les mères influence leur acceptation ou non du test. Secundo, la mère qui par ses connaissances et perceptions même sur le VIH, dont le statut particulier, l'impression de bien-être chez elle et son enfant influence toute réalisation du test pédiatrique VIH. Tertio, l'environnement conjugal de la mère, particulièrement caractérisé par les rapports au sein du couple, sur la facilité de parler du test VIH et sa réalisation chez les deux parents ou chez la mère seulement sont autant de facteurs qui influencent la réalisation effective du dépistage du VIH chez l'enfant. Le principe préventif du VIH, et le désir de faire tester l'enfant ne suffisent pas à eux seuls pour aboutir à sa réalisation effective, selon certaines mères confrontées au refus du conjoint. A l'opposé, les autres mères refusant la réalisation du test pédiatrique disent s'y opposer ; bien entendu, même dans le cas où le conjoint l'accepterait. Discussion: Les mères sont les principales mises en cause et craignent les réprimandes et la stigmatisation. Le père, le conjoint peut être un obstacle, quand il s'oppose au test VIH du nourrisson, ou devenir le facilitateur de sa réalisation s'il est convaincu. Le positionnement du père demeure donc essentiel dans la question de l'acceptabilité du VIH pédiatrique. Les mères en ont conscience et présagent des difficultés à faire dépister ou non les enfants sans avis préalable du conjoint à la fois père, et chef de famille. Conclusion: La question du dépistage pédiatrique du VIH, au terme de notre analyse, met en face trois éléments qui exigent une gestion globale pour assurer une couverture effective. Ces trois éléments n'existeraient pas sans s'influencer, donc ils sont constamment en interaction et empêchent ou favorisent la réalisation ou non du test pédiatrique. Aussi, dans une intention d'aboutir à une couverture effective du dépistage VIH des nourrissons, faut-il tenir compte d'une gestion harmonieuse de ces trois éléments: La première, la mère seule (avec ses connaissances, ses perceptions), son environnement conjugal (de proposition du test intégrant 1- l’époux et / ou père de l'enfant avec ses perceptions et connaissances sur l'infection 2- la facilité de parler du test et sa réalisation chez les deux ou un des parents, la mère) et les connaissances, attitudes et pratiques du personnel de l’établissement sanitaire sur l'infection du VIH. Recommandations: Nos recommandations proposent une redéfinition de l'approche du VIH/sida vers des familles exposées au VIH et une intégration plus accentuée du père facilitant leur propre acceptation du test VIH et celle de leur enfant. PMID:25088574

Pathogenesis of duck circovirus genotype 1 in experimentally infected Pekin ducks.

PubMed

Hong, Y-T; Kang, M; Jang, H-K

2018-05-17

Ducks infected with duck circovirus (DuCV) exhibit feathering disorder, growth retardation, and low body weight. The virus can induce immunosuppression and increase rates of infection caused by other pathogens. The purpose of the present study was to investigate the pathogenesis of DuCV in experimentally infected Pekin ducks. At postmortem examination, gross lesions were observed in the immune organs including bursa of Fabricius (BF), thymus, and spleen. Hemorrhage, lymphocytic depletion, necrosis, and degeneration were observed in the bursal tissues by histological examination. The TUNEL assay was performed with bursal tissue. There was a significant difference of the apoptosis rate between the negative and DuCV-infected ducks. The earliest time point for detection of DuCV DNA in sera, cloacal swabs, and organs was 1 wk post-infection (WPI). Viral shedding was persistent and detectable at the end of the experiment (10 WPI). The findings provide evidence that horizontal transmission and persistent infection are the characteristics of DuCV. The organ with the highest mean viral load was the spleen, followed by BF, cecal tonsil, lung, thymus, liver, and kidney. We successfully established an experimental DuCV genotype 1 (DuCV-1) infection in Pekin ducks and demonstrated the pathogenicity and persistence of DuCV-1. In conclusion, DuCV-1 caused extensive damage to the immune organs that may have resulted in immunosuppression. Pathobiological characteristics of DuCV-1 include systemic infection, persistent infection, and horizontal transmission. These features allow DuCV-1 to circulate more easily in farms and increase the susceptibility of ducks to other diseases.

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 14 (Middletown Limousine Sus - North American Carbide Tooling).

DTIC Science & Technology

1985-01-01

Suite � .4 u ~~c s~~e IBo OFFICE SYP.40O 9 PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER O(AN.’-i U0 j if aPPIicabJC) h,~ .. . (City State and ZIP...4 -4 4 4 A 9 o4 m1W "i 0 M () A W I0100 (n .n00 . . . . . . -.j 0 4 44 44 03 :O 󈧇 0-. (N UN001 WL 4 0 -44 4cm ito o-NN1100II0erP-s-40 -4 WC.1- 1󈧄...00 ( 0 I . ) ) 0-6(CO001 2Z00 000 00 c oG c ) 0 00 *00 Ga* c c 00000 to 0 so 0.aa.s4ha 90Omcc01caCO m((0 -101 - 009L - 009- 9 - LA- I 00 -0 00 444 00 44

Personnel

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-10-13

Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

27 CFR 12.21 - List of examples of names by country.

Code of Federal Regulations, 2010 CFR

2010-04-01

...-Fronsac, Cassis, Cerons, Charlemagne, Chateau Chalon, Chateau-Grillet, Chinon, Chorey-les-Beaunes, Clos de Tart, Clos des Lambrays, Clos Saint-Denis, Collioure, Condrieu, Cornas, Coteaux de l'Aubance, Coteaux du Languedoc, Coteaux du Loir, Coteaux du Lyonnais, Coteaux du Tricastin, Cotes de Duras, Cotes de...

27 CFR 12.21 - List of examples of names by country.

Code of Federal Regulations, 2011 CFR

2011-04-01

...-Fronsac, Cassis, Cerons, Charlemagne, Chateau Chalon, Chateau-Grillet, Chinon, Chorey-les-Beaunes, Clos de Tart, Clos des Lambrays, Clos Saint-Denis, Collioure, Condrieu, Cornas, Coteaux de l'Aubance, Coteaux du Languedoc, Coteaux du Loir, Coteaux du Lyonnais, Coteaux du Tricastin, Cotes de Duras, Cotes de...

Estimates of groundwater age from till and carbonate bedrock hydrogeologic units at Jefferson Proving Ground, Southeastern Indiana, 2007-08

USGS Publications Warehouse

Buszka, Paul M.; Lampe, David C.; Egler, Amanda L.

2010-01-01

During 2007-08, the U.S. Geological Survey, in cooperation with the U.S. Department of the Army, conducted a study to evaluate the relative age of groundwater in Pre-Wisconsinan till and underlying shallow and deep carbonate bedrock units in and near an area at Jefferson Proving Ground (JPG), southeastern Indiana, which was used during 1984-94 to test fire depleted uranium (DU) penetrators. The shallow carbonate unit includes about the upper 40 feet of bedrock below the bedrock-till surface; the deeper carbonate unit includes wells completed at greater depth. Samples collected during April 2008 from 15 wells were analyzed for field water-quality parameters, dissolved gases, tritium, and chlorofluorocarbon (CFC) compounds; samples from 14 additional wells were analyzed for tritium only. Water-level gradients in the Pre-Wisconsinan till and the shallow carbonate unit were from topographically higher areas toward Big Creek and Middle Fork Creek, and their tributaries. Vertical gradients were strongly downward from the shallow carbonate unit toward the deep carbonate unit at 3 of 4 paired wells where water levels recovered after development; indicating the general lack of flow between the two units. The lack of post development recovery of water levels at 4 other wells in the deep carbonate unit indicate that parts of that unit have no appreciable permeability. CFC and tritium-based age dates of Pre-Wisconsinan till groundwater are consistent with infiltration of younger (typically post-1960 age) recharge that 'mixes' with older recharge from less permeable or less interconnected strata. Part of the recharge to three till wells dated from the early to mid-1980s (JPG-DU-03O, JPG-DU-09O, and JPG-DU-10O). Age dates of young recharge in water from two till wells predated 1980 (JPG-DU-04O and JPG-DU-06O). Tritium-based age dates of water from seven other till wells indicated post-1972 age recharge. Most wells in the Pre-Wisconsinan till have the potential to produce groundwater that partially was recharged during or after DU penetrator testing; their water quality can indicate the presence of DU-related contaminants. The shallow carbonate unit near Big Creek is a karst flow system that may be recharged in part from areas with smaller thicknesses of overlying till or through more permeable parts of the till. This is indicated by CFC- and tritium-based piston-flow (non-mixing) model age dates of early-1980s for water from JPG-DU-02I, similar tritium-based ages of water produced from nearby wells MW-5 and MW-11, and cave development along the creek. The CFC and tritium-based age dates indicate that water samples from JPG-DU-01I and JPG-DU-03I were best described as mixtures of post-1984 modern recharge and submodern (1953 or older) recharge. These five wells produced groundwater that was recharged, at least partially, during or after DU-penetrator testing and are within or downgradient from the DU Impact Area with respect to groundwater flow directions inferred from water-level contours. Wells with groundwater age dates that are near to or after the onset (1984) of DU penetrator testing and that have a plausible connection to a contaminant source can be used to indicate the presence or absence of contaminants from DU penetrator or DU-related corrosion products in groundwater. Groundwater-age dates indicate that the ages of recharge sampled from shallow carbonate unit wells JPG-DU-04I, JPG-DU-05I, JPG-DU-06I, JPG-DU-09I, and JPG-DU-10D in easternmost (upgradient) and southernmost wells in the shallow carbonate unit are submodern (1953 or older) and predate the DU testing by at least 30 or more years. Water-quality data from these five wells are not likely to represent effects from DU-projectile testing or corrosion for years. Well JPG-DU-09D in the deep carbonate unit produced groundwater samples with a submodern (1953 or older) age date. The slow recovery of water levels in most wells in the deep carbonate unit is consis

Depleted Uranium—Experience of the United Nations Environmental Programme Missions

NASA Astrophysics Data System (ADS)

Åkerblom, Gustav

2008-08-01

Depleted Uranium (DU) is used in ammunition designed for armour-piercing. DU was used in the Gulf war 1991, wars in Bosnia 1994-1995, Kosovo 1999 and Iraq 2003. The United Nations Environmental Programme (UNEP) Post-Conflict Branch investigated sites where DU was used and evaluated health and environmental risks during missions to Kosovo, Serbia and Bosnia. During a mission to Lebanon in 2006, UNEP also sampled areas where DU was supposed to have been used but did not find any DU. Due to the grave risks to the lives of UN personnel, no UNEP mission was carried out in Iraq. UNEP has provided training for personnel engaged in decontamination of DU in Bosnia and Iraq.

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

PubMed Central

Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

2015-01-01

Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy. PMID:25844599

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.

PubMed

Kharaziha, Pedram; Chioureas, Dimitris; Rutishauser, Dorothea; Baltatzis, George; Lennartsson, Lena; Fonseca, Pedro; Azimi, Alireza; Hultenby, Kjell; Zubarev, Roman; Ullén, Anders; Yachnin, Jeffrey; Nilsson, Sten; Panaretakis, Theocharis

2015-08-28

Docetaxel is a cornerstone treatment for metastatic, castration resistant prostate cancer (CRPC) which remains a leading cause of cancer-related deaths, worldwide. The clinical usage of docetaxel has resulted in modest gains in survival, primarily due to the development of resistance. There are currently no clinical biomarkers available that predict whether a CRPC patient will respond or acquire resistance to this therapy. Comparative proteomics analysis of exosomes secreted from DU145 prostate cancer cells that are sensitive (DU145 Tax-Sen) or have acquired resistance (DU145 Tax-Res) to docetaxel, demonstrated significant differences in the amount of exosomes secreted and in their molecular composition. A panel of proteins was identified by proteomics to be differentially enriched in DU145 Tax-Res compared to DU145 Tax-Sen exosomes and was validated by western blotting. Importantly, we identified MDR-1, MDR-3, Endophilin-A2 and PABP4 that were enriched only in DU145 Tax-Res exosomes. We validated the presence of these proteins in the serum of a small cohort of patients. DU145 cells that have uptaken DU145 Tax-Res exosomes show properties of increased matrix degradation. In summary, exosomes derived from DU145 Tax-Res cells may be a valuable source of biomarkers for response to therapy.

Depleted Uranium and Human Health.

PubMed

Faa, Armando; Gerosa, Clara; Fanni, Daniela; Floris, Giuseppe; Eyken, Peter V; Lachowicz, Joanna I; Nurchi, Valeria M

2018-01-01

Depleted uranium (DU) is generally considered an emerging pollutant, first extensively introduced into environment in the early nineties in Iraq, during the military operation called "Desert Storm". DU has been hypothesized to represent a hazardous element both for soldiers exposed as well as for the inhabitants of the polluted areas in the war zones. In this review, the possible consequences on human health of DU released in the environment are critically analyzed. In the first part, the chemical properties of DU and the principal civil and military uses are summarized. A concise analysis of the mechanisms underlying absorption, blood transport, tissue distribution and excretion of DU in the human body is the subject of the second part of this article. The following sections deal with pathological condition putatively associated with overexposure to DU. Developmental and birth defects, the Persian Gulf syndrome, and kidney diseases that have been associated to DU are the arguments treated in the third section. Finally, data regarding DU exposure and cancer insurgence will be critically analyzed, including leukemia/lymphoma, lung cancer, uterine cervix cancer, breast cancer, bladder cancer and testicular cancer. The aim of the authors is to give a contribution to the debate on DU and its effects on human health and disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells.

PubMed

Cho, Kwang-Jae; Park, Eun-Ji; Kim, Min-Sik; Joo, Young-Hoon

2018-06-01

The aim of this study was to evaluate the impact of CSC on insensitivity to radiotherapy in HNSCC. A radioresistant cell line, FaDu-R, was established using fractionated ionizing radiation. Cells with high and low CD44/ALDH activity were isolated. FaDu-R cells demonstrated significantly increased cell viability after radiation exposure compared with parental cells. CD44 high /ALDH high FaDu-R cells demonstrated significantly faster wound closure (p<0.05) and more efficient invasion (p<0.05) compared to the CD44 high /ALDH high FaDu cells or the CD44 low /ALDH low FaDu-R cells. There was a significant difference in tumor volume between the CD44 high /ALDH high FaDu-R cells and the CD44 high /ALDH high FaDu cells (p<0.05) as well as the CD44 low /ALDH low FaDu-R cells (p<0.05). Cancer stem cells (CSC) were associated with invasion and tumorigenesis in a radioresistant head and neck squamous cell carcinoma (HNSCC) cell line. This concept might help to improve the understanding of these mechanisms and to develop drugs that can overcome radioresistance during radiotherapy. Copyright © 2017 Elsevier B.V. All rights reserved.

Gulf war depleted uranium risks.

PubMed

Marshall, Albert C

2008-01-01

US and British forces used depleted uranium (DU) in armor-piercing rounds to disable enemy tanks during the Gulf and Balkan Wars. Uranium particulate is generated by DU shell impact and particulate entrained in air may be inhaled or ingested by troops and nearby civilian populations. As uranium is slightly radioactive and chemically toxic, a number of critics have asserted that DU exposure has resulted in a variety of adverse health effects for exposed veterans and nearby civilian populations. The study described in this paper used mathematical modeling to estimate health risks from exposure to DU during the 1991 Gulf War for both US troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. The analysis indicated that only a few ( approximately 5) US veterans in vehicles accidentally targeted by US tanks received significant exposure levels, resulting in about a 1.4% lifetime risk of DU radiation-induced fatal cancer (compared with about a 24% risk of a fatal cancer from all other causes). These veterans may have also experienced temporary kidney damage. Iraqi children playing for 500 h in DU-destroyed vehicles are predicted to incur a cancer risk of about 0.4%. In vitro and animal tests suggest the possibility of chemically induced health effects from DU internalization, such as immune system impairment. Further study is needed to determine the applicability of these findings for Gulf War exposure to DU. Veterans and civilians who did not occupy DU-contaminated vehicles are unlikely to have internalized quantities of DU significantly in excess of normal internalization of natural uranium from the environment.

Identification of alternatively spliced isoforms of interleukin-2/15 receptor β chain in ducks.

PubMed

Jeong, Jipseol; Kim, Woo H; Yeo, Jaeseung; Fernandez, Cherry P; Kim, Suk; Lee, Youn-Jeong; Lillehoj, Hyun S; Min, Wongi

2014-12-15

Interleukin (IL)-2 and IL-15 receptor β (IL-2/15Rβ, CD122) play important roles in signal transduction for biological functions of IL-2 and IL-15. We found that ducks possess three different IL-2/15Rβ transcripts, a conventional form (duIL-2/15Rβ) and two variants. Comparisons between the cDNA and genomic sequences revealed that the two variants, duIL-2/15Rβ-d7 and duIL-2/15Rβ-d9, were novel spliced transcripts resulting from skipping exons 7 and 9, respectively. Expression profiles of duIL-2/15Rβ and its isoforms were examined in healthy tissues, concanavalin A (ConA)-stimulated splenic lymphocytes and in livers and spleens of Riemerella anatipestifer-infected ducks using quantitative real-time PCR (qRT-PCR). Generally, duIL-2/15Rβ-d9 expression was undetectable in healthy tissues, ConA-activated samples, and R. anatipestifer-infected ducks. Expression levels of duIL-2/15Rβ transcript were relatively high to moderate in all healthy tissues tested, while duIL-2/15Rβ-d7 expression was low. Compared to untreated controls, expression levels of duIL-2/15Rβ were elevated in ConA-activated splenic lymphocytes and in livers on day 7 in R. anatipestifer-infected ducks, while duIL-2/15Rβ-d7 expression was unchanged. Additionally, COS-7 cells transfected with duIL-2/15Rβ, duIL-2/15Rβ-d7, or duIL-2/15Rβ-d9 constructs generated 73 kilodalton (kDa), 31kDa, and 40kDa proteins, respectively. This study identified three different IL-2/15Rβ transcripts, including two isoforms generated by alternative splicing and their gene expression patterns in stimulated conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

Lignes directrices sur l’aiguillage des cas soupçonnés de cancer du poumon par un médecin de famille ou autre professionnel des soins primaires

PubMed Central

Del Giudice, M. Elisabeth; Young, Sheila-Mae; Vella, Emily T.; Ash, Marla; Bansal, Praveen; Robinson, Andrew; Skrastins, Roland; Ung, Yee; Zeldin, Robert; Levitt, Cheryl

2014-01-01

Résumé Objectif Les présentes lignes directrices visent à aider les médecins de famille et autres généralistes à reconnaître les manifestations cliniques devant éveiller les soupçons quant à la présence d’un cancer du poumon chez les patients. Composition du comité Les membres du comité ont été choisis parmi les leaders régionaux en soins primaires du Réseau provincial des soins primaires et de la lutte contre le cancer d’Action Cancer Ontario et parmi les membres du Groupe sur le siège de la maladie, Cancer du poumon d’Action Cancer Ontario. Méthodes Les présentes lignes directrices sont le fruit d’une revue systématique des données probantes, d’une synthèse des données et d’un examen externe formel effectué par des intervenants canadiens qui ont validé la pertinence des recommandations. Rapport Ces lignes directrices fondées sur des données probantes ont été formulées pour améliorer la prise en charge en contexte canadien des patients qui présentent des manifestations cliniques du cancer du poumon. Conclusion Le dépistage et l’aiguillage précoces des patients atteints de cancer du poumon pourraient en fin de compte aider à réduire les morbidités et mortalités liées au cancer. Ces lignes directrices pourraient aussi s’avérer utiles dans la mise sur pied de programmes de diagnostic du cancer du poumon et pour aider les décideurs à veiller à ce que les ressources appropriées soient en place.

Silicide Formation and Schottky Barrier of Rare-Earth Metals on SI

DTIC Science & Technology

1983-09-30

1981). 4. K. N. Tu, R. D. Thompson and B. Y. Tsaur, App]. Phys. Lett. 38, 626 (1981). 5. H. Norde, J. de Sousa Pires, F. d’Heurle, F. Pesavento , S...Phys. Lett. 38, 626 (1981). 7. H. Plarde, J. de ’’uis Pires, F. dI’Heurle, F. Pesavento , S. Petersson and P. A. Tove, ;!.Phys. L.ett. 38, 865 (1981

High frequency EMI sensing for estimating depleted uranium radiation levels in soil

NASA Astrophysics Data System (ADS)

Shubitidze, Fridon; Barrowes, Benjamin E.; Ballard, John; Unz, Ron; Randle, Adam; Larson, Steve L.; O'Neill, Kevin A.

2018-04-01

This paper studies high (100 kHz up to 15 MHz) frequency electromagnetic responses (HFEMI) for DU metallic pieces and DU contaminated soils and derives a simple empirical expression from the measured HFEMI data for estimating DU contamination levels in soil. Depleted uranium (DU) is the byproduct of uranium enrichment and contains 33% less radioactive isotopes than natural uranium. There are at least thirty facilities at fourteen separate locations in the US, where munitions containing DU have been evaluated or used for training. At these sites, which vary in size, evaluation studies have been conducted with and without catch boxes. In addition, the DoD used DU at open firing ranges as large as thousands of acres (hundreds of hectares), for both artillery and aircraft training. These activities have left a legacy of DU contamination. Currently at military sites where DU munitions have been or are being used, cleanup activities mainly are done by excavating and shipping large volumes of site soil and berm materials to a hazardous material radiation disposal site. This approach is very time consuming, costly, and associated with the potential for exposure of personnel performing excavation and transportation. It also limits range use during the operation. So, there is an urgent need for technologies for rapid surveying of large areas to detect, locate, and removal of DU contaminants at test sites. Additionally, the technologies are needed to detect material at a depth of at least 30 cm as well as discriminate between DU metals and oxides from natural uranium and from other conductive metals such as natural and man-made range clutter. One of the potential technologies for estimating DU radiation levels in soils is HFEMI sensing. In this paper, HFEMI signals are collected for DU metal pieces, sodium diunarate (Na2U2 O3) and tri-uranium octoxide (U3O8). The EMI signal's sensitivity with respect to DU material composition and conditions are illustrated and analyzed. A new scheme for extracting near-surface soil's EM parameters is formulated.

Comparisons between physics-based, engineering, and statistical learning models for outdoor sound propagation.

PubMed

Hart, Carl R; Reznicek, Nathan J; Wilson, D Keith; Pettit, Chris L; Nykaza, Edward T

2016-05-01

Many outdoor sound propagation models exist, ranging from highly complex physics-based simulations to simplified engineering calculations, and more recently, highly flexible statistical learning methods. Several engineering and statistical learning models are evaluated by using a particular physics-based model, namely, a Crank-Nicholson parabolic equation (CNPE), as a benchmark. Narrowband transmission loss values predicted with the CNPE, based upon a simulated data set of meteorological, boundary, and source conditions, act as simulated observations. In the simulated data set sound propagation conditions span from downward refracting to upward refracting, for acoustically hard and soft boundaries, and low frequencies. Engineering models used in the comparisons include the ISO 9613-2 method, Harmonoise, and Nord2000 propagation models. Statistical learning methods used in the comparisons include bagged decision tree regression, random forest regression, boosting regression, and artificial neural network models. Computed skill scores are relative to sound propagation in a homogeneous atmosphere over a rigid ground. Overall skill scores for the engineering noise models are 0.6%, -7.1%, and 83.8% for the ISO 9613-2, Harmonoise, and Nord2000 models, respectively. Overall skill scores for the statistical learning models are 99.5%, 99.5%, 99.6%, and 99.6% for bagged decision tree, random forest, boosting, and artificial neural network regression models, respectively.

Surveys of microfungi in a former industrial area in Duisburg-Nord.

PubMed

Feige, G B; Ale-Agha, N; Dachowski, M; Kricke, R

2002-01-01

One hundred and forty microfungi (Ascomycetes and Deuteromycetes) were collected in the "Landschaftspark Duisburg-Nord" located in North Rhine-Westphalia. New hosts for rarely found fungi are recorded for the first time. New for Germany are Massaria inquinans (Tode) De Not. and Nitschkia grevillei (Rhem) Nannf. on Acer pseudoplatanus L., Pirottaea nigrostriata Graddon on Artemisia vulgaris L., Ceratopycnis clematidis Höhn. on Clematis vitalba L., Dasyscyphus aff. humuli (W. Phillips) Dennis on Humulus lupulus L. and Leptosphaeria derasa (Berk. & Br.) Auersw. on Senecio inaequidens DC. New for North Rhine-Westphalia are Chaetosphaerella phaeostroma (Durieu & Mont.) E. Müller & Booth and Phomopsis platanoides (Cooke) Died. on Acer pseudoplatanus L., Microsphaeropsis pseudaspera Sutton, Mycosphaerella osborniae D. Hawksw. & Sivan. and Phomopsis oblita Sacc. on Artemisia vulgaris L., Leptosphaeria acuta (Fr.) P. Karst. and Leptosphaeria doliolum (Pers.) Ces. & De Not. on Bryonia dioica Jacq., Ophiobolus erythrosporus (Riess) G. Winter and Pleospora herbarum (Pers.) Rabenh. ex Ces. & De Not. on Dipsacus sylvestris (Huds), Keissleriella ocellata (Niessl) Bose on Hypericum perforatum L., Dactylaria aff. graminicola on Lolium perenne L., Siroplacodium aff. atrum on Oenothera beinnis L., Diatrypella favacea (Fr.) Sacc. on Prunus spec., Hapalosphaeria deformans (Syd.) Syd. and Microdiscula rubicola (Bres.) Höhn. on Rubus fructicosus agg. L., Cryptodiaporthe salicina (Pers.) Wehm. on Salix alba L. and Pleurophoma pleurospora (Sacc.) Höhn. on Salix caprea L.

[Surveillance of surgical-site infections: results of the INCISO 1998 Network].

PubMed

Golliot, F; Astagneau, P; Brücker, G

1999-01-01

Surveillance of Surgical-Site Infection (SSI) in general and visceral surgical departments. Prospective cohort study. Inter-regional Co-ordinating Center for Nosocomial Infection Control (C.CLIN Paris-Nord). Regions of Ile de France, Haute Normandie, Nord-Pas de Calais and Picardie. From January 1 to April 1, 1998, each surgical department had included 200 consecutive operations. To diagnose SSI occurring after discharge, patients were followed during one month after surgery. SSI were defined according to standardized criteria. Overall, 16.506 surgeries were followed in 120 surgical units. The rate of postoperative SSI was 3.9% (95CI = [3.6%-4.2%]). The rate of SSI varied from 5.2% for digestive surgery to 0.9% for endocrine system, and 2.3% for cholecystectomy to 16.6% for peritonitis. According to the NNIS index, SSI rates increased from 2.2% for patients with a risk index of 0 to 26.7% for patients with a risk index of 3. The case fatality rate directly or indirectly attributable to SSI was 2.0% (95CI = [1.1%-3.5%]). The high incidence of SSI render crucial the implementation of SSI surveillance in surgery. Risk factors and type of surgical procedures are required to obtain standardized rates for comparisons between services.

Socioeconomic inequalities in dental services utilisation in a Norwegian county: the third Nord-Trondelag Health Survey.

PubMed

Vikum, Eirik; Krokstad, Steinar; Holst, Dorthe; Westin, Steinar

2012-11-01

To assess the level of socioeconomic inequity in dental care utilisation in Norway and enable comparison with recent international comparative studies. We studied dental care utilisation among 17,136 men and 21,414 women in the third Nord-Trøndelag Health Survey (2006-08). Respondents aged 20 years and above were included in the study, and analyses were also performed within subgroups of age and gender (20-39, 40-59, and ≥60 years). Income-related horizontal inequity was estimated by means of concentration indices. Education-related inequity was estimated as relative risks. We found consistent pro-rich income inequity among men and women of all ages. The level of income inequity was highest among men and women ≥60 years, and in this group the income gradient was steepest between the poorest and the middle quintiles. Pro-educated inequity was found exclusively among men and women ≥60 years. General attendance was high (77%). The overall level of income-related inequity in dental services utilisation was low compared to other European countries as reported in two recent international studies of socioeconomic inequalities in dental care utilisation. Pro-rich and pro-educated inequity is a public health challenge mainly in the older part of the population.

Prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang à Kisangani, République Démocratique du Congo

PubMed Central

Bassandja, Jacques Ossinga; Agasa, Salomon Batina; Likwela, Joris Losimba

2014-01-01

Introduction Le paludisme transfusionnel est une réalité en Afrique Sub-saharienne, en raison des transfusions sanguines répétées, peu ou non contrôlées et où les donneurs sont en majorité potentiellement porteurs d'hématozoaires. L'objectif de cette étude était de déterminer la prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang à Kisangani. Méthodes Une étude transversale a été menée au Centre Provincial de Transfusion Sanguine à Kisangani du 1er Décembre 2012 au 31 Mars 2013 et a concerné 480 donneurs bénévoles de sang. Résultats La prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang était de 28,3%. Plasmodium falciparum était l'espèce la plus répandue (96,3%). Près de la moitié des donneurs avait une parasitémie supérieure à 2000 parasites/µl. Les facteurs qui étaient significativement associés à la parasitémie étaient le jeune âge, le 1er don, et la non utilisation de la moustiquaire imprégnée d'insecticide à longue durée (MILD). Conclusion Les résultats de cette étude montrent que la prévalence du portage asymptomatique du plasmodium chez les donneurs bénévoles de sang était élevée, constituant ainsi un risque important de transmission du parasite aux receveurs souvent en mauvais état général. Cependant, l'utilisation de la MILD et la fidélisation des donneurs bénévoles semblent constituer des moyens utiles de réduction du risque de portage asymptomatique du Plasmodium. Une sensibilisation et éventuellement des distributions ciblées de MILD aux donneurs, en particuliers les plus jeunes, pourraient réduire considérablement le portage du Plasmodium parmi les donneurs de sang et ainsi réduire le risque de paludisme transfusionnel. PMID:25328616

Le role du phytoplancton de petite taille (<20 mum) dans les variations des proprietes optiques des eaux du Saint-Laurent

NASA Astrophysics Data System (ADS)

Mas, Sebastien

Les mesures satellitaires de couleur des oceans sont largement determinees par les proprietes optiques inherentes (IOPs) des eaux de surface. D'autre part, le phytoplancton de petite taille (<20 mum) est le plus souvent dominant dans les oceans, et peut donc etre une source importante de variation des IOPs dans les oceans. Dans ce contexte, le but principal de ce doctorat etait de definir l'impact du phytoplancton (<20 mum) sur les variations des proprietes optiques de l'Estuaire et du Golfe du Saint-Laurent (Canada). Afin d'atteindre cet objectif, il etait necessaire de determiner en milieu controle les facteurs de variabilite des proprietes optiques cellulaires et des IOPs du phytoplancton (<20 mum) des eaux du Saint-Laurent, et d'evaluer la contribution du phytoplancton (<20 mum) aux proprietes optiques totales des eaux du Saint-Laurent. Des experiences en laboratoire ont montre que les variations des proprietes optiques des cellules phytoplanctoniques soumises a un cycle jour-nuit, ainsi qu'a des changements concomitants d'intensite lumineuse, peuvent contribuer significativement a la variabilite des proprietes optiques observee en milieu naturel. D'autres experiences ont, quant a elles, mis en evidence que les variations des proprietes optiques des cellules phytoplanctoniques dues aux phases de croissance peuvent alterer les IOPs des oceans, particulierement pendant les periodes de floraison. De plus, la presence de bacteries et de particules detritiques peut egalement affecter la variabilite des IOPs totales, notamment la diffusion. Au printemps, dans l'Estuaire et le Golfe du Saint-Laurent, la contribution du phytoplancton <20 mum aux IOPs presentait des differences regionales evidentes pour les proprietes d'absorption et de diffusion. En plus de la variabilite spatiale, les proprietes optiques cellulaires presentaient des variations journalieres, et ce particulierement pour le picophytoplancton. Enfin, la plupart des differences observees dans les proprietes biooptiques, particulierement l'absorption, etaient attribuables a la contribution du phytoplancton <20 mum. Ceci confirme l'importance de la structure de taille des communautes phytoplanctoniques dans les modeles bio-optiques appliques au Saint-Laurent. L'ensemble des resultats a permis de mettre en evidence l'importance des mecanismes de photoacclimatation et de synchronisation du cycle cellulaire du phytoplancton sur les variations journalieres des IOPs, ainsi que de l'etat physiologique relie au stade de croissance sur les variations temporelles a long terme des IOPs. De plus, le phytoplancton <20 mum contribue de maniere importante aux IOPs et a leur variabilite dans l'Estuaire et le Golfe du St-Laurent, et ce particulierement pour l'absorption. Cette etude de doctorat souligne donc l'importance du phytoplancton <20 mum sur la variabilite des IOPs des oceans.

Genomic characterization of putative allergen genes in peach/almond and their synteny with apple

PubMed Central

Chen, Lin; Zhang, Shuiming; Illa, Eudald; Song, Lijuan; Wu, Shandong; Howad, Werner; Arús, Pere; Weg, Eric van de; Chen, Kunsong; Gao, Zhongshan

2008-01-01

Background Fruits from several species of the Rosaceae family are reported to cause allergic reactions in certain populations. The allergens identified belong to mainly four protein families: pathogenesis related 10 proteins, thaumatin-like proteins, lipid transfer proteins and profilins. These families of putative allergen genes in apple (Mal d 1 to 4) have been mapped on linkage maps and subsequent genetic study on allelic diversity and hypoallergenic traits has been carried out recently. In peach (Prunus persica), these allergen gene families are denoted as Pru p 1 to 4 and for almond (Prunus dulcis)Pru du 1 to 4. Genetic analysis using current molecular tools may be helpful to establish the cause of allergenicity differences observed among different peach cultivars. This study was to characterize putative peach allergen genes for their genomic sequences and linkage map positions, and to compare them with previously characterized homologous genes in apple (Malus domestica). Results Eight Pru p/du 1 genes were identified, four of which were new. All the Pru p/du 1 genes were mapped in a single bin on the top of linkage group 1 (G1). Five Pru p/du 2 genes were mapped on four different linkage groups, two very similar Pru p/du 2.01 genes (A and B) were on G3, Pru p/du 2.02 on G7,Pru p/du 2.03 on G8 and Pru p/du 2.04 on G1. There were differences in the intron and exon structure in these Pru p/du 2 genes and in their amino acid composition. Three Pru p/du 3 genes (3.01–3.03) containing an intron and a mini exon of 10 nt were mapped in a cluster on G6. Two Pru p/du 4 genes (Pru p/du 4.01 and 4.02) were located on G1 and G7, respectively. The Pru p/du 1 cluster on G1 aligned to the Mal d 1 clusters on LG16; Pru p/du 2.01A and B on G3 to Mal d 2.01A and B on LG9; the Pru p/du 3 cluster on G6 to Mal d 3.01 on LG12; Pru p/du 4.01 on G1 to Mal d 4.03 on LG2; and Pru p/du 4.02 on G7 to Mal d 4.02 on LG2. Conclusion A total of 18 putative peach/almond allergen genes have been mapped on five linkage groups. Their positions confirm the high macro-synteny between peach/almond and apple. The insight gained will help to identify key genes causing differences in allergenicity among different cultivars of peach and other Prunus species. PMID:19014629

Personnel

ScienceCinema

None

2017-12-09

Le président du conseil M.Doran explique la décision que le conseil du Cern vient de prendre sur la 4.étape du régime complémentaire des pensions. Le président du comité des finances le Dr.Andersen ainsi que le Prof.Connor(?) prennent aussi la parole

W.E.B. DuBois and the Concepts of Race and Class.

ERIC Educational Resources Information Center

Green, Dan S.; Smith, Earl

1983-01-01

Summarizes and analyzes W.E.B. DuBois's publications on race and class, particularly as he observed the relationships between White and Black Americans from about 1890 to the 1960s. Contends that DuBois's work has been seriously underrated and cites William J. Wilson's work as corroborating and extending DuBois's theories. (CJM)

Toward the Development of a Canadian Less Lethal Weapon Approval Process: A Study of Contemporary Process Models

DTIC Science & Technology

2011-10-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011...validés par l’autorité d’approbation. Lorsqu’il n’existe pas de normes officielles, on utilise une approche de gestion du risque qui comprend une plus...gouvernance qui reprend les éléments clés du modèles du Royaume-Uni, l’incorporation d’un processus de gestion du risque, un énoncé des

Genetic parameters for carcass weight, conformation and fat in five beef cattle breeds.

PubMed

Kause, A; Mikkola, L; Strandén, I; Sirkko, K

2015-01-01

Profitability of beef production can be increased by genetically improving carcass traits. To construct breeding value evaluations for carcass traits, breed-specific genetic parameters were estimated for carcass weight, carcass conformation and carcass fat in five beef cattle breeds in Finland (Hereford, Aberdeen Angus, Simmental, Charolais and Limousin). Conformation and fat were visually scored using the EUROP carcass classification. Each breed was separately analyzed using a multitrait animal model. A total of 6879-19 539 animals per breed had phenotypes. For the five breeds, heritabilities were moderate for carcass weight (h 2=0.39 to 0.48, s.e.=0.02 to 0.04) and slightly lower for conformation (h 2=0.30 to 0.44, s.e.=0.02 to 0.04) and carcass fat (h 2=0.29 to 0.44, s.e.=0.02 to 0.04). The genetic correlation between carcass weight and conformation was favorable in all breeds (r G=0.37 to 0.53, s.e.=0.04 to 0.05), heavy carcasses being genetically more conformed. The phenotypic correlation between carcass weight and carcass fat was moderately positive in all breeds (r P=0.21 to 0.32), implying that increasing carcass weight was related to increasing fat levels. The respective genetic correlation was the strongest in Hereford (r G=0.28, s.e.=0.05) and Angus (r G=0.15, s.e.=0.05), the two small body-sized British breeds with the lowest conformation and the highest fat level. The correlation was weaker in the other breeds (r G=0.08 to 0.14). For Hereford, Angus and Simmental, more conformed carcasses were phenotypically fatter (r P=0.11 to 0.15), but the respective genetic correlations were close to zero (r G=-0.05 to 0.04). In contrast, in the two large body-sized and muscular French breeds, the genetic correlation between conformation and fat was negative and the phenotypic correlation was close to zero or negative (Charolais: r G=-0.18, s.e.=0.06, r P=0.02; Limousin: r G=-0.56, s.e.=0.04, r P=-0.13). The results indicate genetic variation for the genetic improvement of the carcass traits, favorable correlations for the simultaneous improvement of carcass weight and conformation in all breeds, and breed differences in the correlations of carcass fat.

Bovine besnoitiosis in Switzerland: imported cases and local transmission.

PubMed

Basso, Walter; Lesser, Maren; Grimm, Felix; Hilbe, Monika; Sydler, Titus; Trösch, Luzia; Ochs, Hansueli; Braun, Ueli; Deplazes, Peter

2013-12-06

Bovine besnoitiosis is an economically important disease of cattle, caused by Besnoitia besnoiti (Protozoa, Apicomplexa). A considerable spreading of this parasitic infection has been observed in Europe in the last ten years, mainly related to animal trade. In order to investigate the possibility of B. besnoiti being unnoticed introduced and getting established in Switzerland through the import of breeding cattle from France, a total of 767 animals (650 cattle imported from France and 117 cattle that had contact with B. besnoiti positive cattle in Swiss farms) were screened for antibodies against B. besnoiti by both a commercial ELISA and by the indirect fluorescent antibody test (IFAT). A total of 101 (13.17%) samples showed a positive reaction in ELISA (cut-off: percent of positivity [PP] ≥ 15) and 16 (2.09%) samples had IFAT titers ≥ 1:100. Eight of those samples reacted positive in Western blot (WB), corresponding to five imported Limousin cattle (two cows and one bull from France and two cows from Germany) and to three cattle born in Switzerland (one Limousin heifer born from one of the positive German cows, and two adult Braunvieh cows, that had been in contact with one of the French cows at a Swiss farm). Seven of those animals were subclinically infected and one animal showed only very mild signs. They were subsequently slaughtered, and the serological diagnosis could be confirmed by real-time PCR and/or histopathology in seven animals. The most frequent parasite localizations were the tendons and surrounding connective tissue of the distal limbs and the skin of the head region. Furthermore, B. besnoiti could be successfully isolated in vitro from one French, one German and one Swiss cattle (isolates Bb-IPZ-1-CH, Bb-IPZ-2-CH and Bb-IPZ-3-CH). In the current situation in Switzerland, prophylactic and control measures should include a serological examination of cattle to be imported from endemic areas and the culling of all confirmed positive animals from the herd. The evidence of B. besnoiti infection in both imported and locally born cattle shows that the conditions for the establishment and dissemination of this parasite in Switzerland seem to be adequate. Copyright © 2013 Elsevier B.V. All rights reserved.

Digital ulcers in systemic sclerosis: role of flow-mediated dilatation and capillaroscopy as risk assessment tools.

PubMed

Silva, Ivone; Loureiro, Tiago; Teixeira, Andreia; Almeida, Isabel; Mansilha, Armando; Vasconcelos, Carlos; Almeida, Rui

2015-01-01

The aim of this study was to evaluate macrovascular endothelial dysfunction and microvascular damage as clinical markers of peripheral microangiopathy in patients with Raynaud's phenomenon (RP). Seventy-seven secondary RP with systemic sclerosis, 32 primary RP and 34 healthy controls were included in our study. Secondary RP patients were divided into two subgroups: 39 with digital ulcers (DU) and 38 without digital ulcers (non-DU). Patients with DU had significantly lower flow-mediated dilatation values (5.34 ± 7.49%) compared to non-DU patients (16.21 ± 11.31%), primary RP (17.96 ± 12.78%) and controls (20.17 ± 8.86%), p<0.001, favouring macrovascular endothelium dysfunction. Regarding microvascular damage, the DU group had a predominately capillaroscopic late pattern (71.1%) whereas non-DU patients had an active pattern (56.4%). The microangiopathy evolution score was significantly higher in the DU group compared to the non-DU group (4.79 ± 1.82 vs. 1.79 ± 1.56, p<0.001). Flow-mediated dilation was significantly lower in late pattern (6.13 ± 7.09%) compared to active (12.58 ± 10.66%) and early patterns (17.72 ± 14.90%), p = 0.016 and p = 0.044 respectively. Low flow-mediated dilatation and microvascular damage in capillaroscopy are early clinical markers of DU risk in RP patients.

Applications of Capstone depleted uranium aerosol risk data to military combat risk management.

PubMed

Daxon, Eric G; Parkhurst, Mary Ann; Melanson, Mark A; Roszell, Laurie E

2009-03-01

Risks to personnel engaged in military operations include not only the threat of enemy firepower but also risks from exposure to other hazards such as radiation. Combatant commanders of the U.S. Army carefully weigh risks of casualties before implementing battlefield actions using an established paradigm that takes these risks into consideration. As a result of the inclusion of depleted uranium (DU) anti-armor ammunition in the conventional (non-nuclear) weapons arsenal, the potential for exposure to DU aerosols and its associated chemical and radiological effects becomes an element of the commanders' risk assessment. The Capstone DU Aerosol Study measured the range of likely DU oxide aerosol concentrations created inside a combat vehicle perforated with a DU munition, and the Capstone Human Health Risk Assessment (HHRA) estimated the associated doses and calculated risks. This paper focuses on the development of a scientific approach to adapt the risks from DU's non-uniform dose distribution within the body using the current U.S. Department of Defense radiation risk management approach. The approach developed equates the Radiation Exposure Status categories to the estimated radiological risks of DU and makes use of the Capstone-developed Renal Effects Group as a measure of chemical risk from DU intake. Recommendations are provided for modifying Army guidance and policy in order to better encompass the potential risks from DU aerosol inhalation during military operations.

Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

PubMed Central

Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

2011-01-01

Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

The brain is a target organ after acute exposure to depleted uranium.

PubMed

Lestaevel, P; Houpert, P; Bussy, C; Dhieux, B; Gourmelon, P; Paquet, F

2005-09-01

The health effects of depleted uranium (DU) are mainly caused by its chemical toxicity. Although the kidneys are the main target organs for uranium toxicity, uranium can also reach the brain. In this paper, the central effects of acute exposure to DU were studied in relation to health parameters and the sleep-wake cycle of adult rats. Animals were injected intraperitoneally with 144+/-10 microg DU kg-1 as nitrate. Three days after injection, the amounts of uranium in the kidneys represented 2.6 microg of DU g-1 of tissue, considered as a sub-nephrotoxic dosage. The central effect of uranium could be seen through a decrease in food intake as early as the first day after exposure and shorter paradoxical sleep 3 days after acute DU exposure (-18% of controls). With a lower dosage of DU (70+/-8 microg DU kg-1), no significant effect was observed on the sleep-wake cycle. The present study intends to illustrate the fact that the brain is a target organ, as are the kidneys, after acute exposure to a moderate dosage of DU. The mechanisms by which uranium causes these early neurophysiological perturbations shall be discussed.

A review of the environmental corrosion, fate and bioavailability of munitions grade depleted uranium.

PubMed

Handley-Sidhu, Stephanie; Keith-Roach, Miranda J; Lloyd, Jonathan R; Vaughan, David J

2010-11-01

Depleted uranium (DU) is a by-product of nuclear fuel enrichment and is used in antitank penetrators due to its high density, self-sharpening, and pyrophoric properties. Military activities have left a legacy of DU waste in terrestrial and marine environments, and there have been only limited attempts to clean up affected environments. Ten years ago, very little information was available on the dispersion of DU as penetrators hit their targets or the fate of DU penetrators left behind in environmental systems. However, the marked increase in research since then has improved our knowledge of the environmental impact of firing DU and the factors that control the corrosion of DU and its subsequent migration through the environment. In this paper, the literature is reviewed and consolidated to provide a detailed overview of the current understanding of the environmental behaviour of DU and to highlight areas that need further consideration. Copyright © 2010 Elsevier B.V. All rights reserved.

How diet and lifestyle affect duodenal ulcers. Review of the evidence.

PubMed Central

Ryan-Harshman, Milly; Aldoori, Walid

2004-01-01

OBJECTIVE: To demonstrate the role of diet in reducing or aggravating risk of duodenal ulcer (DU). QUALITY OF EVIDENCE: MEDLINE was searched from January 1966 to December 2001 for articles on the relationship between diet and lifestyle and DU using the key words duodenal ulcer and diet, fibre, or lifestyle. Evidence that these factors are associated with DU arose mainly from three case-control and three prospective studies (level II evidence) and from expert opinion (level III evidence). MAIN MESSAGE: A high-fibre diet appears to reduce risk of DU; soluble fibre might be associated with reduced risk also. Vitamin A intake is associated with lower risk of DU. Little evidence indicates that fat, type of fat, protein intake, or consumption of alcohol or caffeine affect the etiology of DU. CONCLUSION: A high-fibre diet, particularly if the fibre comes from fruit and vegetables, could reduce risk of DU; vitamin A might also be beneficial. PMID:15171675

Hématome spontané du méso de l'angle colique droit et du colon transverse compliquant un traitement par anti vitamine K: à propos d'un cas et revue de la littérature

PubMed Central

Traoré, Ibrahim Alain; Zaré, Cyprien; Barro, Sié Drissa; Guibla, Ismaël

2016-01-01

L'hématome spontané du méso de l'angle colique droit et du transverse est une complication rare du traitement anticoagulant par antivitamine K. Nous rapportons un cas d'hématome spontané du méso de l'angle colique droit et du transverse associé à un hémopéritoine de grande abondance chez un patient traité par antivitamine K pour embolie pulmonaire consécutive à une fracture des plateaux tibiaux droits. Le diagnostic doit être fait en urgence. L’échographie abdominale et la tomodensitométrie confirment le diagnostic. Le traitement non opératoire est la règle. Le traitement chirurgical est indiqué en cas de complications telles que la rupture de l'hématome. PMID:27217878

Uranium accumulation in aquatic macrophytes in an uraniferous region: Relevance to natural attenuation.

PubMed

Cordeiro, Cristina; Favas, Paulo J C; Pratas, João; Sarkar, Santosh Kumar; Venkatachalam, Perumal

2016-08-01

Phytoremediation potential of uranium (U) was investigated by submerged, free-floating and rooted emergent native aquatic macrophytes inhabiting along the streams of Horta da Vilariça, a uraniferous geochemical region of NE Portugal. The work has been undertaken with the following objectives: (i) to relate the U concentrations in water-sediment-plant system; and (ii) to identify the potentialities of aquatic plants to remediate U-contaminated waters based on accumulation pattern. A total of 25 plant species culminating 233 samples was collected from 15 study points along with surface water and contiguous sediments. Concentrations of U showed wide range of variations both in waters (0.61-5.56 μg L(-1), mean value 1.98 μg L(-1)) and sediments (124-23,910 μg kg(-1), mean value 3929 μg kg(-1)) and this is also reflected in plant species examined. The plant species exhibited the ability to accumulate U several orders of magnitude higher than the surrounding water. Maximum U concentrations was recorded in the bryophyte Scorpiurium deflexifolium (49,639 μg kg(-1)) followed by Fontinalis antipyretica (35,771 μg kg(-1)), shoots of Rorippa sylvestris (33,837 μg kg(-1)), roots of Oenanthe crocata (17,807 μg kg(-1)) as well as in Nasturtium officinale (10,995 μg kg(-1)). Scorpiurium deflexifolium displayed a high bioconcentration factor (BF) of ∼2.5 × 10(4) (mean value). The species Fontinalis antipyretica, Nasturtium officinale (roots) and Rorippa sylvestris (shoots) exhibited the mean BFs of 1.7 × 10(4), 5 × 10(3) and 4.8 × 10(3) respectively. Maximum translocation factor (TF) was very much pronounced in the rooted perennial herb Rorippa sylvestris showing extreme ability to transport U for the shoots and seems to be promising candidate to be used as bioindicator species. Copyright © 2016 Elsevier Ltd. All rights reserved.

Command and Control (C2) Agility (Agilite du commandement et du controle (C2))

DTIC Science & Technology

2014-10-01

de la rigueur et de l’emploi des méthodes de mesure et d’amélioration de l’agilité du C2. Le spectre des missions... Control and Intelligence (C2I) Section DRDC Valcartier 2459 de la Bravoure Road Québec (Québec) G3J 1X5 CANADA Email: Micheline.Belanger@drdc...Agilité du commandement et du contrôle (C2) (STO-TR-SAS-085) Synthèse L’agilité est la capacité à effectuer avec succès, s’occuper de

Dynamique d'un oscillateur photoréfractif : instabilités et analogie avec la loi de Curie-Weiss

NASA Astrophysics Data System (ADS)

Mathey, P.; Odoulov, S. G.; Rytz, D.

2002-06-01

La dynamique et l'état stationnaire du faisceau issu d'une cavité oscillante comprenant un cristal non-linéaire de titanate de baryum utilisé en tant que miroir à conjugaison de phase sont étudiés. Le paramètre du système étant le gain du milieu non-linéaire, les dépendances de l'intensité de l'oscillation et de l'inverse du temps de réponse sont similaires aux lois de Curie en physique du solide.

Les traces matérielles de la Carte du Ciel. Le cas des observatoires d'Alger et de Bordeaux.

NASA Astrophysics Data System (ADS)

Le Guet Tully, F.; Davoigneau, J.; Lamy, J.; de La Noë, J.; Rousseau, J.-M.; Sadsaoud, H.

2008-06-01

Le chapitre évoque les traces matérielles de la Carte du ciel subsistant dans les observatoires d'Alger et de Bordeaux. Les auteurs examinent d'abord l'opération d'inventaire du patrimoine astronomique entreprise à partir du milieu des années 1990. Ils examinent ensuite les éléments concrets constituant aujourd'hui le patrimoine de la Carte du Ciel : lunettes, abris, accessoires, laboratoires, réseaux, plaques de verre, registres, machines à mesurer les clichés, et cartes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guilmette, Ray A.; Hahn, Fletcher F.; Durbin, P. W.

A number of U. S. veterans of the Persian Gulf War were wounded with depleted uranium (DU) metal fragments as a result of 'friendly fire' incidents, in which Abrams tanks and Bradley fighting vehicles were struck by DU anti-armor munitions. Some of the crew members who survived were left with multiple small fragments of DU in their muscles and soft tissues. The number, size and location of the fragments made them inoperable in general, and therefore subject to long-term retention. Because there was inadequate data to predict the potential carcinogenicity of DU fragments in soft tissues, Hahn et al. (2003)more » conducted a lifespan cancer study in rats. As part of that study, a number of rats were maintained to study the biokinetics and dosimetry of DU implanted intramuscularly in male Wistar rats. Typically, four metal fragments, either as cylindrical pellets or square wafers were implanted into the biceps femoris muscles of the rats. Urine samples were collected periodically during their lifespans, and DU was analyzed in kidneys and eviscerated carcass (minus the implant sites) at death. The daily DU urinary excretion rate increased steeply during the first 30 d after implantation peaking at about 90 d at 3-10 x 10{sup -3}%/d. During the first 150 d, the average excretion rate was 2.4 x 10{sup -3}%/d, decreasing thereafter to about 1 x 10{sup -3}%/d. Serial radiographs were made of the wound sites to monitor gross morphologic changes in the DU implant and the surrounding tissue. As early as 1 w after implantation, radiographs showed the presence of surface corrosion and small, dense bodies near the original implant, presumably DU. This corrosion from the surface of the implant continued with time, but did not result in an increasing amount of DU reaching the blood and urine after the first 3 mo. During this 3-mo period, connective tissue capsules formed around the implants, and are hypothesized to have reduced the access of DU to tissue fluids by limiting the diffusion rate of dissolved chemical forms of DU. Using a model of wound-site retention being developed by a committee of the U.S. National Council of Radiation Protection and Measurements (NCRP), it was found that the average retention of DU in the wound site could be described by a two-component exponential function in which 0.5% of the DU was retained with a half time of 80 d and the remainder with a half time of about 300 y.« less

Coalition Battle Management Language (C-BML) (Language de gestion du champ de bataille (C-BML)

DTIC Science & Technology

2012-02-01

de gestion du champ de bataille (C-BML)) NMSG-048 Final Report. This document...BML) (Langage de gestion du champ de bataille (C-BML)) NMSG-048 Final Report. This document contains information authorized by NATO RTA for...Technical Readiness Level (TRL) that is consistent with an operational deployment. ES - 2 RTO-TR-MSG-048 Langage de gestion du champ de

Characterization of Depleted-Uranium Strength and Damage Behavior

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, III, George T.; Chen, Shuh-Rong; Bronkhorst, Curt A.

2012-12-17

The intent of this report is to document the status of our knowledge of the mechanical and damage behavior of Depleted Uranium(DU hereafter). This report briefly summaries the motivation of the experimental and modeling research conducted at Los Alamos National Laboratory(LANL) on DU since the early 1980’s and thereafter the current experimental data quantifying the strength and damage behavior of DU as a function of a number of experimental variables including processing, strain rate, temperature, stress state, and shock prestraining. The effect of shock prestraining on the structure-property response of DU is described and the effect on post-shock mechanical behaviormore » of DU is discussed. The constitutive experimental data utilized to support the derivation of two constitutive strength (plasticity) models, the Preston-Tonks-Wallace (PTW) and Mechanical Threshold Stress (MTS) models, for both annealed and shock prestrained DU are detailed and the Taylor cylinder validation tests and finite-element modeling (FEM) utilized to validate these strength models is discussed. The similarities and differences in the PTW and MTS model descriptions for DU are discussed for both the annealed and shock prestrained conditions. Quasi-static tensile data as a function of triaxial constraint and spallation test data are described. An appendix additionally briefly describes low-pressure equation-of-state data for DU utilized to support the spallation experiments. The constitutive behavior of DU screw/bolt material is presented. The response of DU subjected to dynamic tensile extrusion testing as a function of temperature is also described. This integrated experimental technique is planned to provide an additional validation test in the future. The damage data as a function of triaxiality, tensile and spallation data, is thereafter utilized to support derivation of the Tensile Plasticity (TEPLA) damage model and simulations for comparison to the DU spallation data are presented. Finally, a discussion of future needs in the area of needed DU strength and damage research at LANL is presented to support the development of physically-based predictive strength and damage modeling capability.« less

Evaluation of the effect of implanted depleted uranium on male reproductive success, sperm concentration, and sperm velocity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arfsten, Darryl P.; Schaeffer, David J.; Johnson, Eric W.

Depleted uranium (DU) projectiles have been used in battle in Iraq and the Balkans and will continue to be a significant armor-penetrating munition for the US military. As demonstrated in the Persian Gulf War, battle injury from DU projectiles and shrapnel is a possibility, and removal of embedded DU fragments from the body is not always practical because of their location in the body or their small size. Previous studies in rodents have demonstrated that implanted DU mobilizes and translocates to the gonads, and natural uranium may be toxic to spermatazoa and the male reproductive tract. In this study, themore » effects of implanted DU pellets on sperm concentration, motility, and male reproductive success were evaluated in adult (P1) Sprague-Dawley rats implanted with 0, 12, or 20, DU pellets of 1x2 mm or 12 or 20 tantalum (Ta) steel pellets of 1x2 mm. Twenty DU pellets of 1x2 mm (760 mg) implanted in a 500-g rat are equal to approximately 0.2 pound of DU in a 154-lb (70-kg) person. Urinary analysis found that male rats implanted with DU were excreting uranium at postimplantation days 27 and 117 with the amount dependent on dose. No deaths or evidence of toxicity occurred in P1 males over the 150-day postimplantation study period. When assessed at postimplantation day 150, the concentration, motion, and velocity of sperm isolated from DU-implanted animals were not significantly different from those of sham surgery controls. Velocity and motion of sperm isolated from rats treated with the positive control compound {alpha}-chlorohydrin were significantly reduced compared with sham surgery controls. There was no evidence of a detrimental effect of DU implantation on mating success at 30-45 days and 120-145 days postimplantation. The results of this study suggest that implantation of up to 20 DU pellets of 1x2 mm in rats for approximately 21% of their adult lifespan does not have an adverse impact on male reproductive success, sperm concentration, or sperm velocity.« less

Understanding the Institutional Dimension of Inter-Agency Collaboration: The Basic Model

DTIC Science & Technology

2012-10-01

period (2009- 2012]. Dacin, M.T., Goodstein, J. and W. R. Scott, “ Institutional Theory and Institutional Change” Introduction to the Special...Zucher, “The Institutionalization of Institutional Theory ”, in S. Clegg, C. Hardy and W.R. Nord (eds) Handbook of Organizational Studies, (1996...and open systems (5th ed.) Upper Saddle River, NJ: Prentice-Hall, p. 270. Scott, W.R., “Approaching adulthood: the maturing of institutional

Results of SEI Independent Research and Development Projects

DTIC Science & Technology

2011-02-01

ft’s Bit- poten- hout a ut de- r for CMU/SEI-2011-TR-002 | 8 more systems to install them. The implication to the Department of Defense and...Computing, June 2011. 2.7.1 Bibliography Challener, David; Yoder, K.; Catherman, R .; Saford, D.; & Van Doom, L. A Practical Guide to Trusted...number of publications and presentations: Brown, N.; Nord, R .; & Ozkaya, I. “Enabling Agility Through Architecture.” CrossTalk 23, 6 (November

Cancer du sein au Maroc: profil phénotypique des tumeurs

PubMed Central

Khalil, Ahmadaye Ibrahim; Bendahhou, Karima; Mestaghanmi, Houriya; Saile, Rachid; Benider, Abdellatif

2016-01-01

Le cancer du sein est le plus fréquent chez la femme et figure parmi les principales causes de mortalité liées au cancer. La curabilité de ce type tumoral est en augmentation, grâce aux programmes de dépistage et aux progrès thérapeutiques, qui ont certes augmenté la survie des patients. Mais des défis restent à relever en rapport avec l’instabilité phénotypique des cellules cancéreuses. L’objectif de ce travail est d’étudier le profil phénotypique du cancer du sein chez les patients pris en charge au Centre Mohammed VI pour le traitement des Cancers, durant les années 2013-2014. Il s’agit d’une étude transversale sur deux années, incluant les cas du cancer du sein pris en charge au Centre. Le recueil des données était fait à partir des dossiers des patients et analysés par le logiciel Epi Info. 1277 patients ont été pris en charge au sein de notre centre. 99,5% des cas de sexe féminin, l’âge moyen était 50,20 ± 11,34 ans. Le type histologique le plus fréquent était le carcinome canalaire infiltrant (80,7% des cas). Le stade diagnostic était précoce (56,9%). Le phénotype moléculaire le plus fréquent était le luminal A (41,4% des cas). Le luminal B, le HER2 et les triples négatifs étaient dans respectivement 10,4%, 6,3%, 11,2% des cas. L’étude du phénotype tumoral des patients atteints du cancer du sein permet l’orientation du clinicien dans le choix du traitement, et des décideurs dans la planification de programmes de lutte contre cette pathologie. PMID:28292037

Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.

PubMed

Renne, Ulla; Langhammer, Martina; Brenmoehl, Julia; Walz, Christina; Zeissler, Anja; Tuchscherer, Armin; Piechotta, Marion; Wiesner, Rudolf J; Bielohuby, Maximilian; Hoeflich, Andreas

2013-01-01

Visceral obesity holds a central position in the concept of the metabolic syndrome characterized by glucose intolerance in humans. However, until now it is unclear if obesity by itself is responsible for the development of glucose intolerance. We have used a novel polygenic mouse model characterized by genetically fixed obesity (DU6) and addressed age- and high fat diet-dependent glucose tolerance. Phenotype selection over 146 generations increased body weight by about 2.7-fold in male 12-week DU6 mice (P<0.0001) if compared to unselected controls (Fzt:DU). Absolute epididymal fat mass was particularly responsive to weight selection and increased by more than 5-fold (P<0.0001) in male DU6 mice. At an age of 6 weeks DU6 mice consumed about twice as much food if compared to unselected controls (P<0.001). Absolute food consumption was higher at all time points measured in DU6 mice than in Fzt:DU mice. Between 6 and 12 weeks of age, absolute food intake was reduced by 15% in DU6 mice (P<0.001) but not in Fzt:DU mice. In both mouse lines feeding of the high fat diet elevated body mass if compared to the control diet (P<0.05). In contrast to controls, DU6 mice did not display high fat diet-induced increases of epididymal and renal fat. Control mice progressively developed glucose intolerance with advancing age and even more in response to the high fat diet. In contrast, obese DU6 mice did neither develop a glucose intolerant phenotype with progressive age nor when challenged with a high fat diet. Our results from a polygenic mouse model demonstrate that genetically pre-determined and life-long obesity is no precondition of glucose intolerance later in life.

Investigation de l'anisotropie du gap supraconducteur dans les composes Ba(Fe(1-x)Co(x))2As2, Ba(1-x)K(x)Fe2As2, LiFeAs et Fe1-deltaTe(1-x)Se(x)

NASA Astrophysics Data System (ADS)

Reid, Jean-Philippe

ommaire La structure du gap supraconducteur et sa modulation sont intimement liees au potentiel d'interaction responsable de l'appariement des electrons d'un supraconducteur. Ainsi, l'etude de la structure du gap-SC et de sa modulation permettent de faire la lumiere sur la nature du mecanisme d'appariement des electrons. A cet egard, les resultats experimentaux des supraconducteurs a base de fer ne cadrent pas dans un seul ensemble, ce qui est en opposition au gap-SC universel des cuprates. Dans ce qui suit, nous presenterons une etude systematique du gap-SC pour plusieurs pnictides. En effet, en utilisant la conductivite thermique, une sonde directionnelle du gap-SC, nous avons ete en mesure de reveler la structure du gap-SC pour les composes suivants : Ba1-xKxFe 2As2, Ba(Fe1-xCo x)2As2, LiFeAs et Fe1-deltaTe 1-xSex. L'etude de ces quatre composes, de trois differentes familles structurales, a pu etablir un tableau partiel mais tres exhaustif de la structure du gap-SC de pnictides. En effet, tel qu'illustre dans cette these, ces quatre composes ne possedent aucun noeud dans leur structure du gap-SC a dopage optimal. Toutefois, a une concentration differente de celle optimale pour les composes K-Ba122 et Co-Ba122, des noeuds apparaissent sur la surface de Fermi, aux extremites 'du dome supraconducteur. Ceci suggere fortement que, pour ces composes, la presence de noeuds sur la surface de Fermi est nuisible a la phase supraconductrice. Mots-cles: Supraconducteurs a base de fer, Pnictides, Structure du gap supraconducteur, Conductivite thermique

Properties, use and health effects of depleted uranium (DU): a general overview.

PubMed

Bleise, A; Danesi, P R; Burkart, W

2003-01-01

Depleted uranium (DU), a waste product of uranium enrichment, has several civilian and military applications. It was used as armor-piercing ammunition in international military conflicts and was claimed to contribute to health problems, known as the Gulf War Syndrome and recently as the Balkan Syndrome. This led to renewed efforts to assess the environmental consequences and the health impact of the use of DU. The radiological and chemical properties of DU can be compared to those of natural uranium, which is ubiquitously present in soil at a typical concentration of 3 mg/kg. Natural uranium has the same chemotoxicity, but its radiotoxicity is 60% higher. Due to the low specific radioactivity and the dominance of alpha-radiation no acute risk is attributed to external exposure to DU. The major risk is DU dust, generated when DU ammunition hits hard targets. Depending on aerosol speciation, inhalation may lead to a protracted exposure of the lung and other organs. After deposition on the ground, resuspension can take place if the DU containing particle size is sufficiently small. However, transfer to drinking water or locally produced food has little potential to lead to significant exposures to DU. Since poor solubility of uranium compounds and lack of information on speciation precludes the use of radioecological models for exposure assessment, biomonitoring has to be used for assessing exposed persons. Urine, feces, hair and nails record recent exposures to DU. With the exception of crews of military vehicles having been hit by DU penetrators, no body burdens above the range of values for natural uranium have been found. Therefore, observable health effects are not expected and residual cancer risk estimates have to be based on theoretical considerations. They appear to be very minor for all post-conflict situations, i.e. a fraction of those expected from natural radiation.

Chemical toxicity and radioactivity of depleted uranium: The evidence from in vivo and in vitro studies.

PubMed

Asic, Adna; Kurtovic-Kozaric, Amina; Besic, Larisa; Mehinovic, Lejla; Hasic, Azra; Kozaric, Mirza; Hukic, Mirsada; Marjanovic, Damir

2017-07-01

The main aim of this review is to summarize and discuss the current state of knowledge on chemical toxicity and radioactivity of depleted uranium (DU) and their effect on living systems and cell lines. This was done by presenting a summary of previous investigations conducted on different mammalian body systems and cell cultures in terms of potential changes caused by either chemical toxicity or radioactivity of DU. In addition, the authors aimed to point out the limitations of those studies and possible future directions. The majority of both in vitro and in vivo studies performed using animal models regarding possible effects caused by acute or chronic DU exposure has been reviewed. Furthermore, exposure time and dose, DU particle solubility, and uranium isotopes as factors affecting the extent of DU effects have been discussed. Special attention has been dedicated to chromosomal aberrations, DNA damage and DNA breaks, as well as micronuclei formation and epigenetic changes, as DU has recently been considered a possible causative factor of all these processes. Therefore, this approach might represent a novel area of study of DU-related irradiation effects on health. Since different studies offer contradictory results, the main aim of this review is to summarize and briefly discuss previously obtained results in order to identify the current opinion on DU toxicity and radioactivity effects in relation to exposure type and duration, as well as DU properties. Copyright © 2017 Elsevier Inc. All rights reserved.

NATO Human Resources (Manpower) Management (Gestion des ressources humaines (effectifs) de l’OTAN)

DTIC Science & Technology

2012-02-01

performances , la gestion des récompenses et du salaire, et la motivation du personnel. En conséquence, il faut que la gestion des ressources humaines...importance au fil du temps. Les ressources humaines, chargées à l’origine de l’embauche, du licenciement, de la paie et de la gestion des ...les effets des systèmes d’évaluation des performances ;

The Seamless Maritime Concept

DTIC Science & Technology

2005-03-01

example demonstrating both the power and profitability of this strategy is the Cirque du Soleil . The Cirque du Soleil is a result of the effort to...ballet, and recognizing the value of the strengths of each and leveraging those strengths into a new market. The Cirque du Soleil is a dramatic...reduce the production costs and over head associated with running a circus, improve the entertainment value, and create a new market. Cirque du

W.E.B. Du Bois and Caste Education: Racial Capitalist Schooling from Reconstruction to Jim Crow

ERIC Educational Resources Information Center

Pierce, Clayton

2017-01-01

This essay provides the first account and examination of caste education in the work of W.E.B. Du Bois. In so doing, I argue that caste education plays a central role in realizing the political and social goals of racial capitalist society for Du Bois. Using Du Bois's caste analytic, I take up and articulate three biopolitical governing strategies…

Ecological risk assessment of depleted uranium in the environment at Aberdeen Proving Ground

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, W.H.; Kennedy, P.L.; Myers, O.B.

1993-01-01

A preliminary ecological risk assessment was conducted to evaluate the effects of depleted uranium (DU) in the Aberdeen Proving Ground (APG) ecosystem and its potential for human health effects. An ecological risk assessment of DU should include the processes of hazard identification, dose-response assessment, exposure assessment, and risk characterization. Ecological risk assessments also should explicitly examine risks incurred by nonhuman as well as human populations, because risk assessments based only on human health do not always protect other species. To begin to assess the potential ecological risk of DU release to the environment we modeled DU transport through the principalmore » components of the aquatic ecosystem at APG. We focused on the APG aquatic system because of the close proximity of the Chesapeake Bay and concerns about potential impacts on this ecosystem. Our objective in using a model to estimate environmental fate of DU is to ultimately reduce the uncertainty about predicted ecological risks due to DU from APG. The model functions to summarize information on the structure and functional properties of the APG aquatic system, to provide an exposure assessment by estimating the fate of DU in the environment, and to evaluate the sources of uncertainty about DU transport.« less

Ecological risk assessment of depleted uranium in the environment at Aberdeen Proving Ground. Annual report, 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clements, W.H.; Kennedy, P.L.; Myers, O.B.

1993-03-01

A preliminary ecological risk assessment was conducted to evaluate the effects of depleted uranium (DU) in the Aberdeen Proving Ground (APG) ecosystem and its potential for human health effects. An ecological risk assessment of DU should include the processes of hazard identification, dose-response assessment, exposure assessment, and risk characterization. Ecological risk assessments also should explicitly examine risks incurred by nonhuman as well as human populations, because risk assessments based only on human health do not always protect other species. To begin to assess the potential ecological risk of DU release to the environment we modeled DU transport through the principalmore » components of the aquatic ecosystem at APG. We focused on the APG aquatic system because of the close proximity of the Chesapeake Bay and concerns about potential impacts on this ecosystem. Our objective in using a model to estimate environmental fate of DU is to ultimately reduce the uncertainty about predicted ecological risks due to DU from APG. The model functions to summarize information on the structure and functional properties of the APG aquatic system, to provide an exposure assessment by estimating the fate of DU in the environment, and to evaluate the sources of uncertainty about DU transport.« less

Molecular characterization of allelic variants of (GATA)n microsatellite loci in parthenogenetic lizards Darevskia unisexualis (Lacertidae).

PubMed

Korchagin, V I; Badaeva, T N; Tokarskaya, O N; Martirosyan, I A; Darevsky, I S; Ryskov, A P

2007-05-01

Populations of parthenogenetic lizards of the genus Darevskia consist of genetically identical animals, and represent a unique model for studying the molecular mechanisms underlying the variability and evolution of hypervariable DNA repeats. As unisexual lineages, parthenogenetic lizards are characterized by some level of genetic diversity at microsatellite loci. We cloned and sequenced a number of (GATA)n microsatellite loci of Darevskia unisexualis. PCR products from these loci were also sequenced and the degree of intraspecific polymorphism was assessed. Among the five (GATA)n loci analysed, two (Du215 and Du281) were polymorphic. Cross-species analysis of Du215 and Du281 indicate that the priming sites at the D. unisexualis loci are conserved in the bisexual parental species, D. raddei and D. valentini. Sequencing the PCR products amplified from Du215 and Du281 and from monomorphic Du323 showed that allelic differences at the polymorphic loci are caused by microsatellite mutations and by point mutations in the flanking regions. The haplotypes identified among the allelic variants of Du281 and among its orthologues in the parental species provide new evidence of the cross-species origin of D. unisexualis. To our knowledge, these data are the first to characterize the nucleotide sequences of allelic variants at microsatellite loci within parthenogenetic vertebrate animals.

Molecular cloning and functional characterization of duck nucleotide-binding oligomerization domain 1 (NOD1).

PubMed

Li, Huilin; Jin, Hui; Li, Yaqian; Liu, Dejian; Foda, Mohamed Frahat; Jiang, Yunbo; Luo, Rui

2017-09-01

Nucleotide-binding oligomerization domain 1 (NOD1) is an imperative cytoplasmic pattern recognition receptor (PRR) and considered as a key member of the NOD-like receptor (NLR) family which plays a critical role in innate immunity through sensing microbial components derived from bacterial peptidoglycan. In the current study, the full-length of duck NOD1 (duNOD1) cDNA from duck embryo fibroblasts (DEFs) was cloned. Multiple sequence alignment and phylogenetic analysis demonstrated that duNOD1 exhibited a strong evolutionary relationship with chicken and rock pigeon NOD1. Tissue-specific expression analysis showed that duNOD1 was widely distributed in various organs, with the highest expression observed in the liver. Furthermore, duNOD1 overexpression induced NF-κB activation in DEFs and the CARD domain is crucial for duNOD1-mediated NF-κB activation. In addition, silencing the duNOD1 decreased the activity of NF-κB in DEFs stimulated by iE-DAP. Overexpression of duNOD1 significantly increased the expression of TNF-α, IL-6, and RANTES in DEFs. These findings highlight the crucial role of duNOD1 as an intracellular sensor in duck innate immune system. Copyright © 2017 Elsevier Ltd. All rights reserved.

Portage vaginal du streptocoque du groupe B chez la femme enceinte au niveau de la région de Marrakech

PubMed Central

Bassir, Ahlam; Dhibou, Hanane; Farah, Majdi; Mohamed, Lharmis; Amal, Addebous; Nabila, Souraa; Abderahim, Aboulfalah; Asmouki, Hamid; Soummani, Abderraouf

2016-01-01

Introduction Le streptocoque du groupe B est le principal agent impliqué dans les infections materno-fœtales, les septicémies et les méningites du nouveau-né à terme. L'objectif est de déterminer le taux de portage maternel du streptocoque du groupe B (SGB) à terme. Méthodes Un prélèvement vaginal a été réalisé de manière prospective chez 275 parturientes lors de l'entrée en salle d'accouchement sur une période de 06 mois. Résultats Le taux de portage était de 20,2%. Le portage était variable en fonction de l’âge gestationnel, il constitue 57.5% entre 37 et 38 semaines d'aménorrhée. Aucun des facteurs de risque n'a était statistiquement prédictif du portage maternel du SGB. Conclusion Le dépistage doit être réalisé à partir de 37 semaines d'aménorrhée, et comme le portage est intermittent, un prélèvement négatif ne garantirait pas que le portage soit négatif à l'accouchement. PMID:27222693

Guideline on Scenario Development for (Distributed) Simulation Environments (Guide en vue du developpement de scenario dans le cadre de simulation distribuee)

DTIC Science & Technology

2015-01-01

des lacunes de M&S du MORS du NMSG a déterminé que le manque d’interopérabilité de la simulation constituait la lacune prioritaire à combler en...matière de capacité, une équipe exploratoire (ET-027) a été constituée au sein du NMSG pour étudier l’interopérabilité de la simulation. L’ET-027 a...élevés (autrement dit, aux niveaux pratique, dynamique et conceptuel) de même que l’automatisation relative du développement, de

Western Dilemma

ScienceCinema

None

2017-12-09

L'association du personnel présente Anthony Sampson, écrivain connu dans le monde entier par ses nombreux ouvrages et publications (International Harold Tribune, Observer, News Week). Il nous parle du commerce des armes et du Moyen Orient.

Kyste hydatique mammaire primitive

PubMed Central

Boufettal, Houssine; Samouh, Naïma

2015-01-01

La localisation mammaire du kyste hydatique est exceptionnelle. De ce fait, le diagnostic est difficile avant l'examen anatomopathologique. Nous rapportons une observation d'un cas de kyste hydatique du sein chez une femme de 32 ans, qui consultait pour un nodule du sein, dont l'imagerie montrait une lésion en rétro-aréolaire du sein gauche, homogène, ovalaire et de contours réguliers. L'examen anatomopathologique objectivait un kyste hydatique à localisation mammaire. Les suites opératoires étaient simples. L'hydatidose est une maladie ubiquitaire, pouvant atteindre tous les organes. Le diagnostic peut être évoqué devant une masse kystique du sein avec des aspects très évocateurs à l'imagerie. La confirmation du diagnostic n'est confirmée qu'après une cytoponction ou une chirurgie d'exérèse qui réalise le traitement de cette pathologique. La négativité du bilan d'extension hydatique permet de retenir une localisation primitive de l’échinococcose. PMID:26185575

Etude de l'affaiblissement du comportement mecanique du pergelisol du au rechauffement climatique

NASA Astrophysics Data System (ADS)

Buteau, Sylvie

Le rechauffement climatique predit pour les prochaines decennies, aura des impacts majeurs sur le pergelisol qui sont tres peu documentes pour l'instant. La presente etude a pour but d'evaluer ces impacts sur les proprietes mecaniques du pergelisol et sa stabilite a long terme. Une nouvelle technique d'essai de penetration au cone a taux de deformation controle, a ete developpee pour caracteriser en place le pergelisol. Ces essais geotechniques et la mesure de differentes proprietes physiques ont ete effectues sur une butte de pergelisol au cours du printemps 2000. Le developpement et l'utilisation d'un modele geothermique 1D tenant compte de la thermodependance du comportement mecanique ont permis d'evaluer que les etendues de pergelisol chaud deviendraient instables a la suite d'un rechauffement de l'ordre de 5°C sur cent ans. En effet, la resistance mecanique du pergelisol diminuera alors rapidement jusqu'a 11,6 MPa, ce qui correspond a une perte relative de 98% de la resistance par rapport a un scenario sans rechauffement.

Drill-hole data, drill-site geology, and geochemical data from the study of Precambrian uraniferous conglomerates of the Medicine Bow Mountains and Sierra Madre of southeastern Wyoming

DOE Office of Scientific and Technical Information (OSTI.GOV)

Karlstrom, K.E.; Houston, R.S.; Schmidt, T.G.

1981-02-01

This volume is presented as a companion to Volume 1: The Geology and Uranium Potential of Precambrian Conglomerates in the Medicine Bow Mountains and Sierra Madre of Southeastern Wyoming; and to Volume 3: Uranium Assessment for Precambrian Pebble Conglomerates in Southeastern Wyoming. Volume 1 summarized the geologic setting and geologic and geochemical characteristics of uranium-bearing conglomerates in Precambrian metasedimentary rocks of southeastern Wyoming. Volume 3 is a geostatistical resource estimate of U and Th in quartz-pebble conglomerates. This volume contains supporting geochemical data, lithologic logs from 48 drill holes in Precambrian rocks of the Medicine Bow Mountains and Sierra Madre,more » and drill site geologic maps and cross-sections from most of the holes.« less

Aerial radiometric and magnetic reconnaissance survey of the Eagle--Dillingham area, Alaska, Mt. Hayes Quadrangle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-06-01

The results of a high-sensitivity aerial gamma-ray spectrometer and magnetometer survey of the Mt. Hayes Quadrangle, Alaska, are presented. Instrumentation and methods are described in Volume 1 of this final report. Statistical and geological analysis of the radiometric data revealed two uranium anomalies worthy of field checking as possible prospects. One is located near Mesozoic granite, which is believed to have the best potential for future economic uranium deposits. Another uranium anomaly is associated with Paleozoic-Precambrian rocks and may be caused by augen gneiss or possibly granitic intrusives. Two weakly uraniferous provinces merit study: one in the northwest, which maymore » be related to the Tertiary-Cretaceous coal-bearing unit, and a second in the northeast, which may be related to Mesozoic granites.« less

[Effects of overexpression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells and its mechanism].

PubMed

Zhou, P; Ma, L; Zhou, J; Xu, J J; Liu, F; Guo, F

2017-05-23

Objective: To explore the effect and mechanism of over-expression of miR-17-92 gene cluster on the biological characteristics of prostate cancer cells. Methods: DU145 cells were transfected with miR-17-92 gene expression plasmid and clones with stable ectopic miR-17-92 overexpression were established. The cell viabilities of DU145-17-92 and DU145-control cells were monitored by xCELLigence system. Cell proliferation and apoptosis were analyzed by Ki-67 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Cell cycle was detected by flow cytometry. Expression levels of proteins involved in apoptosis and Akt pathway were determined by western blotting. Results: xCELLigence RTCA array data showed that the growth rate of DU145-17-92 cells was significantly higher than that of DU145-control cells after 24 h of seeding ( P <0.01). The Ki-67-positive rates of the DU145-control group at 24, 48 and 72 hours were (56.57±1.68)%, (85.48±0.26)% and (90.85±2.08)%, respectively. While the Ki-67 positive rates of the DU145-17-92 group at the desired time points were (73.64±0.68)%, (93.43±1.23)% and (97.36±0.86)%, respectively, with a statistically significant difference at 24 hours ( P <0.01). The percentages of apoptotic cells of the DU145-control group at 24, 48 and 72 hours were (6.76±0.09)%, (14.51±0.86)% and (20.73±1.64)%, respectively, while the apoptotic percentages of the DU145-17-92 group were (1.86±0.15)%, (7.90±0.40)% and (4.92±0.48)%, respectively. The percentages of apoptotic cells of the DU145-control group at different time were significantly higher than those of DU145-17-92 group ( P <0.01 for all). The result of western blotting showed that the protein expression levels of Bcl-2 interacting mediator of cell death (BIM) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in DU145-control cells were 0.83±0.00 and 0.91±0.00, respectively, significantly higher than 0.16±0.00 and 0.13±0.00 of DU145-17-92 cells (both P <0.01). Overexpression of miR17-92 induced the phosphorylation of protein kinase B (Akt) at Ser473 while no appreciable effect on the phosphorylation of Akt at Thr308. The phosphorylated level of extracellular regulated protein kinases (ERK) in DU145-control cells was 0.21±0.01, significantly lower than 0.72±0.01 of DU145-17-92 cells ( P <0.01). Conclusions: Overexpression of miR-17-92 gene plays a pivotal role in growth, proliferation, apoptosis and cell cycle of DU145 cells through down-regulation of apoptotic protein BIM and tumor suppressor PTEN and activation of Akt and ERK signaling pathway.

Séroprévalence et facteurs associés à l’acceptation du Conseil et Dépistage Volontaire du VIH chez l’enfant à Lubumbashi, République Démocratique du Congo

PubMed Central

Ngwej, Dieudonné Tshikwej; Mukuku, Olivier; Malonga, Françoise Kaj; Luboya, Oscar Numbi; Kakoma, Jean-Baptiste Sakatolo; Wembonyama, Stanis Okitotsho

2017-01-01

Résumé Introduction Malgré le dépistage du VIH proposé lors de la naissance ou au cours des consultations préscolaires, la proportion des enfants qui croissent ou décèdent sous statut sérologique au VIH inconnu est importante en République Démocratique du Congo (RDC). L’objectif de cette étude était de déterminer la séroprévalence au cours d’un dépistage volontaire et d’identifier les facteurs associés à l’acceptation du conseil et dépistage du VIH (CDV) en dehors de la maladie ou de toute exposition au VIH dans une population pédiatrique à Lubumbashi, RDC. Méthodes Il s’agissait d’une étude prospective transversale à visée analytique menée du 1er août 2006 au 31 septembre 2007. Elle avait été réalisée dans 4 centres communautaires de CDV répartis dans 4 zones de santé de la ville de Lubumbashi en RDC (Lubumbashi, Ruashi, Kampemba et de Kenya). L’étude avait consisté à faire le dépistage volontaire du VIH chez les enfants de moins de 15 ans. Les caractéristiques sociodémographiques et les paramètres relatifs au conseil et dépistage volontaire ont été étudiés. Les analyses statistiques descriptives usuelles et une régression logistique ont été réalisées. Résultats Sur 463 enfants dépistés du VIH, 41 (8,9%; IC 95%: 6,5%-11,9%) ont été testés positifs. L’acceptation du conseil et dépistage volontaire du VIH en dehors de la maladie ou de l’exposition au VIH était significativement plus élevée lorsque l’enfant était âgé de plus de 2 ans (Odds ratio ajusté (ORa) = 3,6 [IC 95%: 1,1-12,2]), lorsque le statut sérologique du VIH des parents était négatif ou inconnu (ORa = 27,4 [IC 95%: 9,4-80,0]), lorsque l’un ou l’autre ou les deux parents biologiques étaient en vie (ORa = 24,9 [IC 95%: 2,4-250,8]) et lorsque la connaissance du lieu de dépistage était fait par des moyens autres que le professionnel de santé (ORa = 2,9 [IC 95%: 1,0-7,9]). Conclusion Notre étude montre une forte prévalence du VIH chez les enfants justifiant la nécessité de réaliser le CDV qui est significativement accepté par leurs parents et tuteurs dans la ville de Lubumbashi. PMID:29255552

Chemours Pompton Lakes Works Site, Pompton Lakes, NJ

EPA Pesticide Factsheets

E.I. DuPont De Nemours & Company is located at 2000 Cannonball Road, Pompton Lakes, New Jersey. The DuPont Pompton Lakes Works site (DuPont) occupies approximately 570 acres of land in Pompton Lakes and Wanaque.

La reconstruction du sourcil par greffon composite du cuir chevelu: une astuce pour faciliter la technique

PubMed Central

El Omari, Mounia; El Mazouz, Samir; Gharib, Noureddine; EL Abbassi, Abdallah

2015-01-01

Les sourcils jouent un rôle important dans l’équilibre esthétique du visage. Leur reconstruction ou ophriopoïése, après séquelle de brûlure fait partie intégrante du programme de réhabilitation de la face brûlée. Plusieurs techniques ont été décrites. Nous insistons ici sur l'intérêt d'une technique simple, à la portée de tous les chirurgiens, et dont la méthode et les résultats peuvent être améliorés par un dessin bien planifié des zones donneuse et receveuse: la greffe composite prélevée au niveau du cuir chevelu dessinée à l'aide d'un calque du sourcil controlatéral. PMID:26401195

In Vivo Detection of Hyperoxia-Induced Pulmonary Endothelial Cell Death Using 99mTc-Duramycin

PubMed Central

Audi, Said H.; Jacobs, Elizabeth R.; Zhao, Ming; Roerig, David L.; Haworth, Steven T.; Clough, Anne V.

2014-01-01

Introduction: 99mTc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Methods: Rats were exposed to room air (normoxic) or >98% O2 for 48 or 60 hours. DU was injected i.v. in anesthetized rats, scintigraphy images were acquired at steady-state, and lung DU uptake was quantified from the images. Post-mortem, the lungs were removed for histological studies. Sequential lung sections were immunostained for caspase activation and endothelial and epithelial cells. Results: Lung DU uptake increased significantly (p < 0.001) by 39% and 146% in 48-hr and 60-hr exposed rats, respectively, compared to normoxic rats. There was strong correlation (r2 = 0.82, p = 0.005) between lung DU uptake and the number of cleaved caspase 3 (CC3) positive cells, and endothelial cells accounted for more than 50% of CC3 positive cells in the hyperoxic lungs. Histology revealed preserved lung morphology through 48 hours. By 60 hours there was evidence of edema, and modest neutrophilic infiltrate. Conclusions: Rat lung DU uptake in vivo increased after just 48 hours of >98% O2 exposure, prior to the onset of any substantial evidence of lung injury. These results suggest that apoptotic endothelial cells are the primary contributors to the enhanced DU lung uptake, and support the utility of DU imaging for detecting early endothelial cell death in vivo. PMID:25218023

Teratogenicity of depleted uranium aerosols: A review from an epidemiological perspective

PubMed Central

Hindin, Rita; Brugge, Doug; Panikkar, Bindu

2005-01-01

Background Depleted uranium is being used increasingly often as a component of munitions in military conflicts. Military personnel, civilians and the DU munitions producers are being exposed to the DU aerosols that are generated. Methods We reviewed toxicological data on both natural and depleted uranium. We included peer reviewed studies and gray literature on birth malformations due to natural and depleted uranium. Our approach was to assess the "weight of evidence" with respect to teratogenicity of depleted uranium. Results Animal studies firmly support the possibility that DU is a teratogen. While the detailed pathways by which environmental DU can be internalized and reach reproductive cells are not yet fully elucidated, again, the evidence supports plausibility. To date, human epidemiological data include case examples, disease registry records, a case-control study and prospective longitudinal studies. Discussion The two most significant challenges to establishing a causal pathway between (human) parental DU exposure and the birth of offspring with defects are: i) distinguishing the role of DU from that of exposure to other potential teratogens; ii) documentation on the individual level of extent of parental DU exposure. Studies that use biomarkers, none yet reported, can help address the latter challenge. Thoughtful triangulation of the results of multiple studies (epidemiological and other) of DU teratogenicity contributes to disentangling the roles of various potentially teratogenic parental exposures. This paper is just such an endeavor. Conclusion In aggregate the human epidemiological evidence is consistent with increased risk of birth defects in offspring of persons exposed to DU. PMID:16124873

Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebinger, M.H.; Essington, E.H.; Gladney, E.S.

1990-06-01

The environmental fate of fragments of depleted uranium (DU) penetrators in soils and waters at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) is a concern to the Testing and Evaluation Command (TECOM) of the US Army. This report presents the information from preliminary soil and water samples that were collected from the humid woodlands of APG and the arid Sonoran Desert of YPG. Soil samples collected beneath a penetrator fragment of the firing range at APG showed approximately 12% DU by weight in the surface horizon and DU significantly above background to a depth of about 20 cm.more » Samples of surface water at APG showed U only at background levels, and bottom sediments showed background U levels but with isotopic ratios of DU instead of natural U. Soil samples beneath a penetrator fragment at YPG showed about 0.5% by weight U in the surface horizon, but only background concentrations and isotopic ratios of U between 8 and 20 cm depth. Results from this preliminary study indicate that DU at APG was redistributed primarily be dissolution and transport with water and possibly by migration of DU colloids or DU attached to small particles. Redistribution at YPG, however, was mainly due to erosion of DU fragments from the impact area and redeposition in washes that drain the area. Proposed work for FY90-FY92 includes additional field sampling, laboratory column studies, and the development of a computer model of DU redistribution at both sites. 39 refs., 11 figs., 5 tabs.« less

Selection and life history traits of tebufenozide-resistant sugarcane borer (Lepidoptera: Crambidae).

PubMed

Akbar, W; Ottea, J A; Beuzelin, J M; Reagan, T E; Huang, F

2008-12-01

Varying susceptibility to tebufenozide was recorded in the sugarcane borer, Diatraea saccharalis (F.) (Lepidoptera: Crambidae), collected from Louisiana sugarcane locations with different selection pressures. Results from diet incorporation bioassays with tebufenozide indicated significant increases in LC50 (3.78-fold) and LC90 (7-fold) values for a colony from Duson (DU), an area with higher selection pressure, compared with a colony from Alexandria (ALEX), an area with no selection pressure. Differences were not detected in LC50 values among colonies from areas where use of tebufenozide was discontinued or rotated with other chemistries. Selections with tebufenozide of DU larvae over 12 generations resulted in a highly resistant colony (DU-R) with 27.1- and 83.3-fold increases in LC50 and LC90 values, respectively. Comparison of pupal weight, days to pupation, and emergence after exposure to an equitoxic (LC20) concentration of tebufenozide revealed a decrease in pupal weight (34 and 33% for males and females, respectively), and an increase in days to pupation (47 and 40% for males and females, respectively), and emergence (43 and 33% for males and females, respectively) for the DU-R colony compared with the parent DU colony. Fecundity of DU-R females decreased to 72 eggs per female compared with 180 (DU) and 261 (ALEX). Egg viability of the ALEX and DU colonies was 61 and 56%, respectively, whereas only 27% of eggs laid by females from the DU-R colony hatched. These results are discussed in terms of their practical implications for control of D. saccharalis in Louisiana sugarcane.

Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

PubMed Central

Yang, David Yi; Bracken, Keyna

2016-01-01

Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

Pseudarthrose de l'extrémité inférieure du fémur traitée par mégaprothèse: à propos d'un cas et revue de la littérature

PubMed Central

Elidrissi, Mohammed; Hammou, Nassereddine; Shimi, Mohammed; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

2013-01-01

Les pseudarthroses de l'extrémité distale du fémur sont relativement rares du fait de la qualité de la vascularisation de cette région. La prise en charge d'une telle complication pose un certain nombre de difficultés. Le traitement chirurgical fait appel à plusieurs techniques conservatrices, le traitement par prothèse peut s'avérer utile quand la perte de substance est importante chez le sujet âgé. L'objectif de ce travail est de discuter l'intérêt de la mégaprothèse du genou dans le traitement de la pseudarthrose de l'extrémité distale du fémur, à travers l’étude de l'observation d'une patiente et revue de la littérature. Il s'agit d'une patiente âgée de 62 ans qui présente une pseudarthrose de l'extrémité distale du fémur gauche. Sur le plan clinique la patiente présente des douleurs du genou gauche, avec gène fonctionnelle importante. Le score de l'IKS préopératoire était de 60. Elle a bénéficié d'un remplacement prothétique par une mégaprothèse du genou. En postopératoire la flexion du genou était à 90°, le score de l'IKS était de 130. A travers l’étude de cette observation, et la revue de la littérature, nous pensons que l'utilisation de mégaprothèse du genou, constitue une solution efficace et durable pour le traitement des pseudarthroses du fémur distal et particulièrement chez le sujet âgé. Cette technique permet de répondre aux impératifs d'un tel aléa de la consolidation: lutter contre la douleur et garantir une mobilité satisfaisante permettant de répondre aux besoins de la vie quotidienne du patient et ainsi améliorer sa qualité de vie. PMID:24396555

Analyse de L'ancrage des Vortex Intergrains pour le Yttrium BARYUM(2) CUIVRE(3) OXYGENE(7) Polycristallin

NASA Astrophysics Data System (ADS)

Fournier, Patrick

Le Modele de l'Etat Critique Generalise (MECG) est utilise pour decrire les proprietes magnetiques et de transport du YBa_2Cu_3O _7 polycristallin. Ce modele empirique permet de relier la densite de courant critique a la densite de lignes de flux penetrant dans la region intergrain. Deux techniques de mesures sont utilisees pour caracteriser nos materiaux. La premiere consiste a mesurer le champ au centre d'un cylindre creux en fonction du champ magnetique applique pour des temperatures comprises entre 20 et 85K. En variant l'epaisseur de la paroi du cylindre creux, il est possible de suivre l'evolution des cycles d'hysteresis et de determiner des champs caracteristiques qui varient en fonction de cette dimension. En utilisant un lissage des resultats experimentaux, nous determinons J _{co}, H_ {o} et n, les parametres du MECG. La forme des cylindres, avec une longueur comparable au diametre externe, entrai ne la presence d'un champ demagnetisant qui peut etre inclus dans le modele theorique. Ceci nous permet d'evaluer la fraction du volume ecrante, f _{g}, ainsi que le facteur demagnetisant N. Nous trouvons que J_{ co}, H_{o} et f_{g} dependent de la temperature, tandis que n et N (pour une epaisseur de paroi fixe) n'en dependent pas. La deuxieme technique consiste a mesurer le courant critique de lames minces en fonction du champ applique pour differentes temperatures. Nous utilisons un montage que nous avons developpe permettant d'effectuer ces mesures en contact direct avec le liquide refrigerant, i.e. dans l'azote liquide. Nous varions la temperature du liquide en variant la pression du gaz au-dessus du bain d'azote. Cette methode nous permet de balayer des temperatures entre 65K et la temperature critique du materiau ({~ }92K). Nous effectuons le lissage des courbes de courant critique en fonction du champ applique encore a l'aide du MECG, pour a nouveau obtenir ses parametres. Pour trois echantillons avec des traitements thermiques differents, les parametres sont differents confirmant que la variation des proprietes macroscopiques de ces supraconducteurs est intimement reliee a la nature des jonctions entre les grains et de la surface des grains. L'oxygenation prolongee retablit les proprietes initiales des echantillons qui se sont degrades durant le recuit des contacts.

Control of Defects in Aluminum Gallium Nitride ((Al)GaN) Films on Grown Aluminum Nitride (AlN) Substrates

DTIC Science & Technology

2013-02-01

Nord, J.; Albe, K.; Erhart, P.; Nordlund, K. Modelling of Compound Semiconductors: Analytical Bond-order Potential for Gallium , Nitrogen and Gallium ...Control of Defects in Aluminum Gallium Nitride ((Al)GaN) Films on Grown Aluminum Nitride (AlN) Substrates by Iskander G. Batyrev, Chi-Chin Wu...Aluminum Gallium Nitride ((Al)GaN) Films on Grown Aluminum Nitride (AlN) Substrates Iskander G. Batyrev and N. Scott Weingarten Weapons and

Theory of Multipartite Entanglement for X-States

DTIC Science & Technology

2015-04-29

funded Frank J. Horton Fellowship, and the National Sci- ence Foundation. I would like to thank my fellow graduate students Ivan Minchev and Jason Nord...utility of our approach by using the fidelities recently reported on the creation of GHZ-states among up to fourteen ions to establish lower bounds on...to six ions are given in Table 4.1. The fidelities of states with larger numbers of qubits are not big enough to establish non-trivial lower bounds

Fiches pratiques: Pour ne pas perdre le nord...; Mariage a la russe; Un pari sur Paris; Une tenebreuse affaire (Practical Ideas: Don't Lose Your Bearings...; Marriage Russian Style; A Bet on Paris; A Gloomy Affair).

ERIC Educational Resources Information Center

Rocca, Carla; And Others

1990-01-01

Four ideas for language classroom activities are presented, including a counting and calculation game, an exercise for developing familiarity with the parts and style of a newspaper article, an activity to help adolescents anticipating travel in a French city, and analysis of the textual structure of a current events circle. (MSE)

Review of environmental exposure concentrations of chemical warfare agent residues and associated the fish community risk following the construction and completion of the Nord Stream gas pipeline between Russia and Germany.

PubMed

Sanderson, Hans; Fauser, Patrik; Rahbek, Malene; Larsen, Jørn Bo

2014-08-30

This paper compiles all the measured chemical warfare agent (CWA) concentrations found in relation to the Nord Stream pipeline work in Danish waters for the past 5 years. Sediment and biota sampling were performed along the pipeline route in four campaigns, prior to (in 2008 and 2010), during (in 2011) and after (in 2012) the construction work. No parent CWAs were detected in the sediments. Patchy residues of CWA degradation products of Adamsite, Clark I, phenyldichloroarsine, trichloroarsine and Lewisite II, were detected in a total of 29 of the 391 sediment samples collected and analyzed the past 5 years. The cumulative fish community risk quotient for the different locations, calculated as a sum of background and added risk, ranged between 0 and 0.017 suggesting a negligible acute CWA risk toward the fish community. The added risk from sediment disturbance in relation to construction of the pipelines represents less than 2% of the total risk in the areas with the highest calculated risk. The analyses of benthic infauna corroborate the finding of CWA related low risk across the years. There was no significant difference in CWA risk before (2008) and after the pipeline construction (2012). Copyright © 2014 Elsevier B.V. All rights reserved.

Detailed study of sulfide scaling at La Courneuve Nord, a geothermal exploitation of the Paris basin, France

DOE Office of Scientific and Technical Information (OSTI.GOV)

Honegger, J.L.; Czernichowski-Lauriol, I.; Criaud, A.

1989-01-01

The fluid of the Dogger aquifer is always used through a closed loop formed by the production well, the heating plant and the injection well. After two or three years of exploitation of the geothermal doublets in the northern part of the Paris basin, scaling and plugging problems have appeared in some cases. The results of the detailed study carried out at La Courneuve Nord, a typical site of this area, are presented. The drawdown of production rate, scaling in the heat exchanger and the increase of injection pressure required a rapid decision for workover operations on the wells. Thesemore » cleaning operations and joint research studies allowed the authors to identify the cause of the plugging as well as to locate these deposits and to estimate their importance. After cleaning operations, the hydraulic properties of the reservoir seem to be recovered. Chemical and mineralogical analyses of these deposits identified the presence of a large variety of iron sulfide and a typical corrosion product. Biochemical and bacteriological studies show a very high content of micro-organisms. A chemical model, IPDEGAZ, is used to calculate the evolution of the saturation indexes of the fluid with respect to iron sulfide phases. The effects of parameters such as pressure, temperature, degassing and addition of iron by corrosion are simulated. The results of the observation and modeling approaches are compared.« less

Differences in prevalence of bullying victimization between native and immigrant children in the Nordic countries: a parent-reported serial cross-sectional study.

PubMed

Bjereld, Y; Daneback, K; Petzold, M

2015-07-01

Bullying among children is a problem with severe consequences for the victim. The present study examined parent-reported bullying victimization among children in the Nordic countries at two points in time, 1996 and 2011, and studied differences in prevalence of bullying victimization between immigrant and native children. Data came from the parent-reported NordChild, carried out in the Nordic countries in 1996 and 2011. NordChild is a serial cross-sectional comparative study. A total of 7107 children aged 7-13 were included in the analyses. The prevalence of bullying victimization in the total Nordic countries was lower in 2011 (19.2%) than 1996 (21.7%). Difference in prevalence of bullying victimization was found both between native and immigrant children, and between countries. The largest difference in prevalence of bullying victimization was measured in Sweden 2011, where 8.6% of the native children were bullied, to be compared with the 27.8% of the immigrant children. Immigrant children had higher odds to be bullied than native children in Norway, Sweden and in the total Nordic countries at both measurements, also when adjusted for potentially confounding factors. The higher prevalence of bullying victimization among immigrant children should be taken into consideration in the design and development of preventive work against bullying. © 2014 John Wiley & Sons Ltd.

Artificial recharge through a well in fissured carbonate rock, west St. Paul, Minnesota

USGS Publications Warehouse

Reeder, Harold O.; Wood, Warren W.; Ehrlich, G.G.; Sun, Ren Jen

1976-01-01

The injection test demonstrated that it is hydrologically feasible to recharge the Prairie du Chien Group and the Jordan Sandstone artificially through wells completed in the Prairie du Chien Group. The fissures in the Prairie du Chien Group act as conduits through which water spreads. The water passes into the Jordan Sandstone from the Prairie du Chien over a larger area than it would if it were injected directly into the Jordan.

Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population.

PubMed

Arachchi, H S Jayasinghe; Kalra, Vijay; Lal, Banwari; Bhatia, Vikram; Baba, C S; Chakravarthy, S; Rohatgi, S; Sarma, Priyangshu M; Mishra, V; Das, Bimal; Ahuja, Vineet

2007-12-01

The duodenal ulcer (DU)-promoting gene (dupA) of Helicobacter pylori has been identified as a novel virulent marker associated with an increased risk for DU. The presence or absence of dupA gene of H. pylori present in patients with DU and functional dyspepsia in North Indian population was studied by polymerase chain reaction (PCR) and hybridization analysis. One hundred and sixty-six patients (96 DU and 70 functional dyspepsia) were included in this study. In addition, sequence diversity of dupA gene of H. pylori found in these patients was analyzed by sequencing the PCR products jhp0917 and jhp0918 on both strands with appropriate primers. PCR and hybridization analyses indicated that dupA gene was present in 37.5% (36/96) of H. pylori strains isolated from DU patients and 22.86% (16/70) of functional dyspepsia patients (p < or = .05). Of these, 35 patients with DU (97.2%) and 14 patients with functional dyspepsia (81.25%) were infected by H. pylori positive for cagA genotype. Furthermore, the presence of dupA was significantly associated with the cagA-positive genotype (p < or = .02). Results of our study have shown that significant association of dupA gene with DU in this population. The dupA gene can be considered as a novel virulent marker for DU in this population.

Hazardous Waste Cleanup: DuPont Imaging Department in Parlin, New Jersey

EPA Pesticide Factsheets

DuPont has owned and operated a chemical manufacturing plant on Cheesequake Road in Parlin, New Jersey, since 1904. DuPont manufactured a variety of products at the plant including, photographic films, automotive paints, pigments, adhesives, thinners,

Can preoperative detrusor underactivity influence surgical outcomes of 120 W HPS vaporization of the prostate (PVP) or holmium laser enucleation of the prostate (HoLEP)? A serial 3-year follow-up study.

PubMed

Cho, Min Chul; Park, Juhyun; Kim, Jung Kwon; Cho, Sung Yong; Jeong, Hyeon; Oh, Seung-June; Paick, Jae-Seung; Son, Hwancheol

2018-01-01

To determine the influence of preoperative detrusor underactivity (DU) on serial long-term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries. A total of 382 men, who underwent 120W-HPS/PVP or HoLEP for LUTS/BPH and for whom 36-month follow-up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88). DU was defined as bladder contractility index of <100. Surgical outcomes were assessed at postoperative 6, 12, 24, and 36 months using IPSS, uroflowmetry, and serum PSA. All four groups maintained improvements in voiding symptom score (VSS), storage symptom score, total-IPSS, QOL index, maximum flow rate (Qmax), post-void residual urine volume (PVR), and bladder voiding efficiency (BVE) compared with baseline up to 3 years postoperatively. There were no significant differences in improvements of postoperative IPSS parameters including QOL index between men with and without DU throughout the follow-up period after HPS or HoLEP. In men with DU, there were no significant differences in improvements of postoperative QOL index, Qmax, PVR, or BVE between HPS and HoLEP groups throughout the follow-up period, except for VSS and total IPSS. Serum PSA reductions after HoLEP were greater than after PVP. Improvements in LUTS, Qmax, and BVE can maintain up to 3 years after HPS or HoLEP for LUTS/BPH, irrespective of the presence or absence of preoperative DU. Although HoLEP may provide more durable improvement of VS in men with DU than HPS, there seems to be no difference in improvement of QOL or Qmax or BVE between HPS and HoLEP. © 2017 Wiley Periodicals, Inc.

Depleted uranium exposure and health effects in Gulf War veterans

PubMed Central

Squibb, Katherine S; McDiarmid, Melissa A

2006-01-01

Health effects stemming from depleted uranium (DU) exposure in a cohort of Gulf War veterans who were in or on US Army vehicles hit by friendly fire involving DU munitions are being carefully monitored through the Baltimore Veterans Affairs (VA) DU Follow-Up Program initiated in 1993. DU exposure in this cohort has been directly measured using inductively coupled plasma-mass spectrometer (ICP-MS) isotopic analysis for DU in urine specimens. Soldiers with embedded DU fragments continue to excrete elevated concentrations of U in their urine, documenting ongoing systemic exposure to U released from their fragments. Biennial surveillance visits provide a detailed health assessment that includes basic clinical measures and surveillance for early changes in kidney function, an expected target organ for U. Tests also include measurements of genotoxicity and neuroendocrine, neurocognitive and reproductive function. With the exception of the elevated urine U excretion, no clinically significant expected U-related health effects have been identified to date. Subtle changes in renal function and genotoxicity markers in veterans with urine U concentrations greater than 0.1 μg−1 creatinine, however, indicate the need for continued surveillance of these DU-exposed veterans. PMID:16687268

CFD Simulations of a Ferry in Head Seas

DTIC Science & Technology

2011-03-01

la durée de vie en fatigue globale du navire. Il est important, pour la conception, l’exploitation et la gestion du cycle de ...vibration de frottement qui exerce une contrainte sur la structure de coque primaire et qui a un effet défavorable sur la durée de vie en fatigue globale du ...laquelle ne peut simuler directement la physique du tossage. Le présent rapport contient les résultats d’une étude faisant

Development of Measures of Effectiveness and Performance from Cognitive Work Analysis Products

DTIC Science & Technology

2012-02-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC Atlantic CR 2011...le nouveau concept du système. Ce rapport vise à déterminer si les résultats du travail de conception peuvent aider à élaborer des mesures de ...l’information (IIDS). Le contrat actuel comportait deux objectifs : élaborer des mesures de l’efficacité (MOE) et du rendement (MOP) pour

V2010 Security Planning and Operations: A Social Network Study of Key Information Sharing Relationships

DTIC Science & Technology

2011-05-01

la scurit. Je vous remercie de votre temps et de votre contribution. Susan G. McIntyre Knowledge Management/ Gestion du savoir...National Defence, 2011 © Sa Majesté la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2011 DRDC CSS TR 2011...avantages du renforcement de la communication horizontale au sein du gouvernement fédéral, surtout en présence d’organismes de

Depleted uranium: properties, military use and health risks.

PubMed

Fairlie, Ian

2009-01-01

This article describes uranium and depleted uranium (DU), their similar isotopic compositions, how DU arises, its use in munitions and armour-proofing, and its pathways for human exposures. Particular attention is paid to the evidence of DU's health effects from cell and animal experiments and from epidemiology studies. It is concluded that a precautionary approach should be adopted to DU and that there should be a moratorium on its use by military forces. International efforts to this end are described.

In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin.

PubMed

Audi, Said H; Jacobs, Elizabeth R; Zhao, Ming; Roerig, David L; Haworth, Steven T; Clough, Anne V

2015-01-01

(99m)Tc-duramycin, DU, is a SPECT biomarker of tissue injury identifying cell death. The objective of this study is to investigate the potential of DU imaging to quantify capillary endothelial cell death in rat lung injury resulting from hyperoxia exposure as a model of acute lung injury. Rats were exposed to room air (normoxic) or >98% O2 for 48 or 60 hours. DU was injected i.v. in anesthetized rats, scintigraphy images were acquired at steady-state, and lung DU uptake was quantified from the images. Post-mortem, the lungs were removed for histological studies. Sequential lung sections were immunostained for caspase activation and endothelial and epithelial cells. Lung DU uptake increased significantly (p<0.001) by 39% and 146% in 48-hr and 60-hr exposed rats, respectively, compared to normoxic rats. There was strong correlation (r(2)=0.82, p=0.005) between lung DU uptake and the number of cleaved caspase 3 (CC3) positive cells, and endothelial cells accounted for more than 50% of CC3 positive cells in the hyperoxic lungs. Histology revealed preserved lung morphology through 48 hours. By 60 hours there was evidence of edema, and modest neutrophilic infiltrate. Rat lung DU uptake in vivo increased after just 48 hours of >98% O2 exposure, prior to the onset of any substantial evidence of lung injury. These results suggest that apoptotic endothelial cells are the primary contributors to the enhanced DU lung uptake, and support the utility of DU imaging for detecting early endothelial cell death in vivo. Copyright © 2014 Elsevier Inc. All rights reserved.

Organosulfates and organic acids in Arctic aerosols: speciation, annual variation and concentration levels

NASA Astrophysics Data System (ADS)

Hansen, A. M. K.; Kristensen, K.; Nguyen, Q. T.; Zare, A.; Cozzi, F.; Nøjgaard, J. K.; Skov, H.; Brandt, J.; Christensen, J. H.; Ström, J.; Tunved, P.; Krejci, R.; Glasius, M.

2014-02-01

Sources, composition and occurrence of secondary organic aerosols (SOA) in the Arctic were investigated at Zeppelin Mountain, Svalbard, and Station Nord, northeast Greenland, during the full annual cycle of 2008 and 2010 respectively. We focused on the speciation of three types of SOA tracers: organic acids, organosulfates and nitrooxy organosulfates from both anthropogenic and biogenic precursors, here presenting organosulfate concentrations and compositions during a full annual cycle and chemical speciation of organosulfates in Arctic aerosols for the first time. Aerosol samples were analysed using High Performance Liquid Chromatography coupled to a quadrupole Time-of-Flight mass spectrometer (HPLC-q-TOF-MS). A total of 11 organic acids (terpenylic acid, benzoic acid, phthalic acid, pinic acid, suberic acid, azelaic acid, adipic acid, pimelic acid, pinonic acid, diaterpenylic acid acetate (DTAA) and 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA)), 12 organosulfates and one nitrooxy organosulfate were identified at the two sites. Six out of the 12 organosulfates are reported for the first time. Concentrations of organosulfates follow a distinct annual pattern at Station Nord, where high concentration were observed in late winter and early spring, with a mean total concentration of 47 (±14) ng m-3, accounting for 7 (±2)% of total organic matter, contrary to a considerably lower organosulfate mean concentration of 2 (±3) ng m-3 (accounting for 1 (±1)% of total organic matter) observed during the rest of the year. The organic acids followed the same temporal trend as the organosulfates at Station Nord; however the variations in organic acid concentrations were less pronounced, with a total mean organic acid concentration of 11.5 (±4) ng m-3 (accounting for 1.7 (±0.6)% of total organic matter) in late winter and early spring, and 2.2 (±1) ng m-3 (accounting for 0.9 (±0.4)% of total organic matter) during the rest of the year. At Zeppelin Mountain, organosulfate and organic acid concentrations remained relatively constant during most of the year at amean concentration of 15 (±4) ng m-3 (accounting for 4 (±1)% of total organic matter) and 3.9 (±1) ng m-3 (accounting for 1.1 (±0.1)% of total organic matter) respectively. However during four weeks of spring remarkably higher concentrations of total organosulfates (23-36 ng m-3) and total organic acids (7-10 ng m-3) were observed. The periods of observed elevated organosulfate and organic acid concentration at Station Nord and at Zeppelin Mountain coincided with the Arctic Haze period. Furthermore, backwards air mass trajectories indicated northern Eurasia as the main source region of the Arctic haze aerosols at both sites. Periods with air mass transport from Russia to Zeppelin Mountain were associated with a doubled number of detected organosulfate species compared with periods of air mass transport from the Arctic Ocean, Scandinavia and Greenland. Our analysis showed the presence of organosulfates and organic acids of both biogenic and anthropogenic origin throughout the year at both Arctic sites. As the formation of organosulfates binds inorganic sulfate, their presence may possibly affect the formation and lifetime of clouds in the Arctic atmosphere.

W. E. B. Du Bois at the center: from science, civil rights movement, to Black Lives Matter.

PubMed

Morris, Aldon

2017-03-01

I am honoured to present the 2016 British Journal of Sociology Annual Lecture at the London School of Economics. My lecture is based on ideas derived from my new book, The Scholar Denied: W.E.B. Du Bois and the Birth of Modern Sociology. In this essay I make three arguments. First, W.E.B. Du Bois and his Atlanta School of Sociology pioneered scientific sociology in the United States. Second, Du Bois pioneered a public sociology that creatively combined sociology and activism. Finally, Du Bois pioneered a politically engaged social science relevant for contemporary political struggles including the contemporary Black Lives Matter movement. © London School of Economics and Political Science 2017.

The du Bois sign.

PubMed

Voelpel, James H; Muehlberger, Thomas

2011-03-01

According to the current literature, the term "du Bois sign" characterizes the condition of a shortened fifth finger as a symptom of congenital syphilis, Down syndrome, dyscrania, and encephalic malformation. Modern medical dictionaries and text books attribute the eponym to the French gynecologist Paul Dubois (1795-1871). Yet, a literature analysis revealed incorrect references to the person and unclear definitions of the term. Our findings showed that the origin of the term is based on observations made by the Swiss dermatologist Charles du Bois (1874-1947) in connection with congenital syphilis. In addition, a further eponymical fifth finger sign is closely associated with the du Bois sign. In conclusion, the du Bois sign has only limited diagnostic value and is frequently occurring in the normal healthy population.

Révision de la sous-famille des Metaracoelophryinae de Puytorac 1972 (Oligohymenophora : Hoplytophryida : Hoplytophryidae), ciliés astomes du tube digestif d’oligochètes terricoles d’Afrique : description de cinq espèces nouvelles

PubMed Central

Fokam, Z.; Ngassam, P.; Nana, P.A.; Bricheux, G.; Bouchard, P.; Sime Ngando, T.

2012-01-01

Cinq nouvelles espèces de ciliés astomes, présentes dans le tube digestif de vers oligochètes du genre Alma du Cameroun, ont été décrites. Les techniques utilisées sont : l’observation vitale, la coloration au DAPI, la microscopie électronique à balayage et les imprégnations argentiques selon Fernandez Galiano, 1966. Ce travail confirme la présence des genres Paracoelophrya et Dicoelophrya dans le tube digestif des oligochètes du genre Alma du Gabon et du Cameroun ; il permet de faire une synthèse récapitulative de la sous-famille des Metaracoelophryinae. De plus, est confirmée l’homogénéité de ce groupe, et est reposée la question de la parenté phylogénétique des Hoplitophryida. PMID:22314239

An investigation of duck circovirus and co-infection in Cherry Valley ducks in Shandong Province, China.

PubMed

Zhang, Xingxiao; Jiang, Shijin; Wu, Jiaqiang; Zhao, Qin; Sun, Yani; Kong, Yibo; Li, Xiaoxia; Yao, Meiling; Chai, Tongjie

2009-01-13

The co-infection of duck circovirus (DuCV) with Riemerella anatipestifer (RA) or/and Escherichia coli (E. coli) or/and duck hepatitis virus I (DHV-I) in Cherry Valley ducks in China's Shandong Province was investigated by using polymerase-chain-reaction (PCR)-based methods. For this study, 742 ducks sampled at random from 70 duck farms during 2006-2007 were examined using PCR and dot-blot hybridisation (DBH) tests. Overall the DuCV infection rate was 33.29%. Compared with those at 2 weeks of age, the ducks at 3-4 weeks of age were more susceptible to DuCV infection. Compared with the DuCV-negative ones, the DuCV-positive ducks had a higher rate of infection by DHV-I (25.5% vs. 7.475%), RA (23.48% vs. 8.28%) and E. coli (16.19% vs. 4.85%). This investigation shows that DuCV infection is common in Cherry Valley ducks on some farms in Shandong Province.

Etude thermo-hydraulique de l'ecoulement du moderateur dans le reacteur CANDU-6

NASA Astrophysics Data System (ADS)

Mehdi Zadeh, Foad

Etant donne la taille (6,0 m x 7,6 m) ainsi que le domaine multiplement connexe qui caracterisent la cuve des reacteurs CANDU-6 (380 canaux dans la cuve), la physique qui gouverne le comportement du fluide moderateur est encore mal connue de nos jours. L'echantillonnage de donnees dans un reacteur en fonction necessite d'apporter des changements a la configuration de la cuve du reacteur afin d'y inserer des sondes. De plus, la presence d'une zone intense de radiations empeche l'utilisation des capteurs courants d'echantillonnage. En consequence, l'ecoulement du moderateur doit necessairement etre etudie a l'aide d'un modele experimental ou d'un modele numerique. Pour ce qui est du modele experimental, la fabrication et la mise en fonction de telles installations coutent tres cher. De plus, les parametres de la mise a l'echelle du systeme pour fabriquer un modele experimental a l'echelle reduite sont en contradiction. En consequence, la modelisation numerique reste une alternative importante. Actuellement, l'industrie nucleaire utilise une approche numerique, dite de milieu poreux, qui approxime le domaine par un milieu continu ou le reseau des tubes est remplace par des resistances hydrauliques distribuees. Ce modele est capable de decrire les phenomenes macroscopiques de l'ecoulement, mais ne tient pas compte des effets locaux ayant un impact sur l'ecoulement global, tel que les distributions de temperatures et de vitesses a proximite des tubes ainsi que des instabilites hydrodynamiques. Dans le contexte de la surete nucleaire, on s'interesse aux effets locaux autour des tubes de calandre. En effet, des simulations faites par cette approche predisent que l'ecoulement peut prendre plusieurs configurations hydrodynamiques dont, pour certaines, l'ecoulement montre un comportement asymetrique au sein de la cuve. Ceci peut provoquer une ebullition du moderateur sur la paroi des canaux. Dans de telles conditions, le coefficient de reactivite peut varier de maniere importante, se traduisant par l'accroissement de la puissance du reacteur. Ceci peut avoir des consequences majeures pour la surete nucleaire. Une modelisation CFD (Computational Fluid Dynamics) detaillee tenant compte des effets locaux s'avere donc necessaire. Le but de ce travail de recherche est de modeliser le comportement complexe de l'ecoulement du moderateur au sein de la cuve d'un reacteur nucleaire CANDU-6, notamment a proximite des tubes de calandre. Ces simulations servent a identifier les configurations possibles de l'ecoulement dans la calandre. Cette etude consiste ainsi a formuler des bases theoriques a l'origine des instabilites macroscopiques du moderateur, c.-a-d. des mouvements asymetriques qui peuvent provoquer l'ebullition du moderateur. Le defi du projet est de determiner l'impact de ces configurations de l'ecoulement sur la reactivite du reacteur CANDU-6.

Products of in Situ Corrosion of Depleted Uranium Ammunition in Bosnia and Herzegovina Soils.

PubMed

Wang, Yuheng; von Gunten, Konstantin; Bartova, Barbora; Meisser, Nicolas; Astner, Markus; Burger, Mario; Bernier-Latmani, Rizlan

2016-11-15

Hundreds of tons of depleted uranium (DU) ammunition were used in previous armed conflicts in Iraq, Bosnia and Herzegovina, and Serbia/Kosovo. The majority (>90%) of DU penetrators miss their target and, if left in the environment, corrode in these postconflict zones. Thus, the best way to understand the fate of bulk DU material in the environment is to characterize the corrosion products of intact DU penetrators under field conditions for extended periods of time. However, such studies are scarce. To fill this knowledge gap, we characterized corrosion products formed from two intact DU penetrators that remained in soils in Bosnia and Herzegovina for over seven years. We used a combination of X-ray powder diffraction, electron microscopy, and X-ray absorption spectroscopy. The results show that metaschoepite (UO 3 (H 2 O) 2 ) was a main component of the two DU corrosion products. Moreover, studtite ((UO 2 )O 2 (H 2 O) 2 ·2(H 2 O)) and becquerelite (Ca(UO 2 ) 6 O 4 (OH) 6 ·8(H 2 O)) were also identified in the corrosion products. Their formation through transformation of metaschoepite was a result of the geochemical conditions under which the penetrators corroded. Moreover, we propose that the transformation of metaschoepite to becquerelite or studtite in the DU corrosion products would decrease the potential for mobilization of U from corroded DU penetrators exposed to similar environments in postconflict areas.

Applications of Capstone Depleted Uranium Aerosol Risk Data to Military Combat Risk Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daxon, Eric G.; Parkhurst, MaryAnn; Melanson, Mark A.

2009-03-01

Risks to personnel engaged in military operations include not only the threat of enemy firepower but also risks from exposure to other hazards such as radiation. Combatant commanders of the U. S. Army carefully weigh risks of casualties before implementing battlefield actions using an established paradigm that take these risks into consideration. As a result of the inclusion of depleted uranium (DU) anti-armor ammunition in the conventional (non-nuclear) weapons arsenal, the potential for exposure to DU aerosols and its associated chemical and radiological effects becomes an element of the commanders’ risk assessment. The Capstone DU Aerosol Study measured the rangemore » of likely DU oxide aerosol concentrations created inside a combat vehicle perforated with a DU munition, and the Capstone Human Health Risk Assessment (HHRA) estimated the associated doses and calculated risks. This paper focuses on the development of a scientific approach to adapt the risks from DU’s non uniform dose distribution within the body using the current U.S. Department of Defense (DoD) radiation risk management approach. The approach developed equates the Radiation Exposure Status (RES) categories to the estimated radiological risks of DU and makes use of the Capstone-developed Renal Effects Group (REG) as a measure of chemical risk from DU intake. Recommendations are provided for modifying Army guidance and policy in order to better encompass the potential risks from DU aerosol inhalation during military operations.« less

Are dentists enough aware of infectious risk associated with dental unit waterlines ?

PubMed

Robert, Amélie; Bousseau, Anne; Costa, Damien; Barbot, Vanessa; Imbert, Christine

2013-07-10

Environmental conditions in DU encourage biofilm development. This biofilm may represent a risk for patients and dental staff exposed to water and aerosols generated during dental cares, particularly for immunocompromised persons. A survey was conducted on the 175 dental surgeons of the department of Vienne (France) to investigate the motivations of dental practitioners to renew their DU, their awareness levels with respect to infectious risks related to water circulating within DU, and methods used for the maintenance of DU waterlines. These dentists were only partially aware of the need for maintaining DU waterlines. For this maintaining, chemical treatments and purges of pipes were carried out by 88% and 91.5% of dentists respectively ; chemical treatments were usually on a continous mode and dentists seemed to have complete confidence in their DU supplier regarding the choice and the use of chemical treatments. Flushes were performed only once per day in most cases (63%). This survey also highlighted that dentists were not enough aware of water related infectous risk, even though 68% estimated that the development of a biofilm within DU waterlines was an actual risk. Finally, very positively, dentists strongly indicated their wish to be more informed regarding all these risks. Although these results are based on a relatively small sample, corresponding to dentists of a French department, they clearly suggest that awareness of dental surgeons is still insufficient and must be performed to permit an effective prevention of infectious risk related to DU waterlines.

Archaeal abundance in post-mortem ruminal digesta may help predict methane emissions from beef cattle

NASA Astrophysics Data System (ADS)

Wallace, R. John; Rooke, John A.; Duthie, Carol-Anne; Hyslop, Jimmy J.; Ross, David W.; McKain, Nest; de Souza, Shirley Motta; Snelling, Timothy J.; Waterhouse, Anthony; Roehe, Rainer

2014-07-01

Methane produced from 35 Aberdeen-Angus and 33 Limousin cross steers was measured in respiration chambers. Each group was split to receive either a medium- or high-concentrate diet. Ruminal digesta samples were subsequently removed to investigate correlations between methane emissions and the rumen microbial community, as measured by qPCR of 16S or 18S rRNA genes. Diet had the greatest influence on methane emissions. The high-concentrate diet resulted in lower methane emissions (P < 0.001) than the medium-concentrate diet. Methane was correlated, irrespective of breed, with the abundance of archaea (R = 0.39), bacteria (-0.47), protozoa (0.45), Bacteroidetes (-0.37) and Clostridium Cluster XIVa (-0.35). The archaea:bacteria ratio provided a stronger correlation (0.49). A similar correlation was found with digesta samples taken 2-3 weeks later at slaughter. This finding could help enable greenhouse gas emissions of large animal cohorts to be predicted from samples taken conveniently in the abattoir.

Nucleotide Substitution in 3' Arm of Bovine MIR-2467 in Five Cattle Breeds.

PubMed

Łukaszewicz, Aneta; Basiak, Szymon; Proskura, Witold Stanisław; Dybus, Andrzej

2015-01-01

The T > C single nucleotide polymorphism (SNP) in the MIR2467 gene was investigated in order to confirm its presence in cattle genome and to check for possible differences in its genotype distribution among different breeds. Additional purpose of the study was to investigate in silico potential effect of that substitution on the structure and stability of precursor mir-2467. The study involved 634 individuals of five cattle breeds: Angus, Hereford, Holstein-Friesian, Jersey, and Limousin, which were genotyped using PCR-RFLP assay. In this study, the presence of T > C polymorphism at position 24 was observed in all the cattle breeds excepting Hereford. In addition, the differences in the genotype distribution among analyzed breeds were indicated. On the basis of minimum free energy structure prediction, the C allele was indicated to have possible impact on decreasing the stability of the pre-mir-2467, thus altering its ability to regulate target genes expression.

The study of protein biomarkers to understand the biochemical processes underlying beef color development in young bulls.

PubMed

Gagaoua, Mohammed; Terlouw, E M Claudia; Picard, Brigitte

2017-12-01

This study investigates relationships between 21 biomarkers and meat color traits of Longissimus thoracis muscles of young Aberdeen Angus and Limousin bulls. The relationships found allowed to propose metabolic processes underlying meat color. The color coordinates were related with several biomarkers. The relationships were in some cases breed-dependent and the variability explained in the regression models varied between 31 and 56%. The correlations between biomarkers and color parameters were sometimes opposite between breeds. The PCA using the 21 biomarkers and the instrumental color coordinates showed that these variables discriminated efficiently between the two studied breeds. Results are coherent with earlier studies on other beef breeds showing that several proteins belonging to different but partly related biological pathways involved in muscle contraction, metabolism, heat stress and apoptosis are related to beef color. The results suggest that in future, biomarkers may be used to classify meat cuts sampled early post-mortem according to their forthcoming color. Copyright © 2017 Elsevier Ltd. All rights reserved.

Of Climate Change and Crystal Balls: The Future Consequences of Climate Change in Africa

DTIC Science & Technology

2012-01-01

Stationarity Is Dead For most of human existence, climate determined where and how we lived. Homo sapiens emerged sometime within the past half million...no. 1 ( January 2012): 35–50. 62. Schuyler Null, “ El Niño, Conflict, and Environmental Determinism: Assessing Climate’s Links to Instability,” New...Security Beat, 5 October 2011, http://www.newsecuritybeat.org/2011/10/ el -nino-conflict- and-environmental.html. 63. Ragnhild Nordås and Nils Petter

Necessity of a Security Barrier in the Nord Kivu and Ituri Border Provinces of the Democratic Republic of the Congo

DTIC Science & Technology

2016-06-10

cobalt, wood products, crude oil , coal, zinc, manganese, coltan, uranium, a flourishing flora, and a diversified fauna. The DRC’s geological potentiality...Poor knowledge of informatics has also limited the speed of research. Finally, the complexity and ambiguity of the problem, and the insistence on...Pong Massif in South Vietnam. By 1974, the trail was a four-lane wide route and also boasted four oil pipelines. From 1965 to 1975, Hanoi moved about

"Cirque du Freak."

ERIC Educational Resources Information Center

Rivett, Miriam

2002-01-01

Considers the marketing strategies that underpin the success of the "Cirque du Freak" series. Describes how "Cirque du Freak" is an account of events in the life of schoolboy Darren Shan. Notes that it is another reworking of the vampire narrative, a sub-genre of horror writing that has proved highly popular with both adult and…

27 CFR 12.31 - List of approved names by country.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., Chateau Yquem, Chateauneuf-du-Pape, Chenas, Chevalier-Montrachet, Chiroubles, Clos de la Roche, Clos de Vougeot, Corton, Corton-Charlemagne, Cote de Beaune, Cote de Beaune-Villages, Cote de Brouilly, Cote de Nuits, Cote de Nuits-Villages, Cote Rotie, Coteaux du Layon, Cotes du Rhone, Echezeaux, Entre-Deux-Mers...

27 CFR 12.31 - List of approved names by country.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Chateau Yquem, Chateauneuf-du-Pape, Chenas, Chevalier-Montrachet, Chiroubles, Clos de la Roche, Clos de Vougeot, Corton, Corton-Charlemagne, Cote de Beaune, Cote de Beaune-Villages, Cote de Brouilly, Cote de Nuits, Cote de Nuits-Villages, Cote Rotie, Coteaux du Layon, Cotes du Rhone, Echezeaux, Entre-Deux-Mers...

Meeting DG's

ScienceCinema

None

2017-12-09

Le DG J.Adams commente les 3 thèmes de la réunion: 1.) le prochain DG du Cern (qui sera H.Schopper) 2.) le LEP 3.) les conclusions du comité des finances concernant salaires, allocations etc. Discussion entre le DG J.Adams, Mons.Ullmann, chef du personel et l'auditoire

Brain stem hypoplasia associated with Cri-du-Chat syndrome.

PubMed

Hong, Jin Ho; Lee, Ha Young; Lim, Myung Kwan; Kim, Mi Young; Kang, Young Hye; Lee, Kyung Hee; Cho, Soon Gu

2013-01-01

Cri-du-Chat syndrome, also called the 5p-syndrome, is a rare genetic abnormality, and only few cases have been reported on its brain MRI findings. We describe the magnetic resonance imaging findings of a 1-year-old girl with Cri-du-Chat syndrome who showed brain stem hypoplasia, particularly in the pons, with normal cerebellum and diffuse hypoplasia of the cerebral hemispheres. We suggest that Cri-du-Chat syndrome chould be suspected in children with brain stem hypoplasia, particularly for those with high-pitched cries.

Managed Readiness Simulator (MARS) V2: Implementation of the Managed Readiness Model

DTIC Science & Technology

2010-12-01

mesure de répondre aux besoins propres à un ensemble de tâches opérationnelles. La première version du programme MARS (V1) a...mise en œuvre du modèle de gestion de la disponibilité opérationnelle du MARS V2 dans la nouvelle architecture logicielle. La public cible de ce...l’établissement. Le but de la présente étude est de documenter la mise en œuvre du modèle de

Critical Energy Infrastructure Protection in Canada

DTIC Science & Technology

2010-12-01

la participation volontaire du secteur privé dans le système intégré proposé et sur des mesures visant à encourager...que le gouvernement attache beaucoup d’importance à la protection des infrastructures énergétiques essentielles. Neuf ans après les attaques du 11...producteurs d’énergie et des services énergétiques qui sont si essentiels à la prospérité et au bien-être du Canada ainsi qu’à la sécurité de l’Amérique du

Ceremony 25th birthday Cern

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2006-05-08

Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

Capability Challenges in the Human Domain for Intelligence Analysis: Report on Community-Wide Discussions with Canadian Intelligence Professionals

DTIC Science & Technology

2012-03-01

renseignement au cours de l’AF 2012-2013. Cette enquête examinera plus en profondeur les problèmes humains dans la production du renseignement afin...the Queen in Right of Canada, as represented by the Minister of National Defence, 2011 © Sa Majesté la Reine ( en droit du Canada), telle que...ensemble. L’étude a également analysé de quelle façon la recherche en science du comportement peut aider la collectivité du renseignement à aborder

2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de bataille pour les operations en coalition)

DTIC Science & Technology

2010-02-01

Feb 2010 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de bataille pour les opérations en...RTO MEETING PROCEEDINGS MP-MSG-079 2010 Coalition Battle Management Language Workshop (Atelier 2010 sur le langage de gestion du champ de ...RTO-MP-MSG-079 ES - 3 Atelier 2010 sur le langage de gestion du champ de bataille pour les opérations en coalition (RTO-MP-MSG-079

The health effects of depleted uranium munitions: a summary.

PubMed

2002-06-01

There has been a substantial amount of public discussion on the health effects of the use of depleted uranium (DU) munitions. In response to this concern the Royal Society set up an independent, expert working group to investigate the health effects of DU munitions. The Royal Society has now produced two reports, and this summary covering the key conclusions and recommendations from both reports. The part I report considered the increased risks of radiation-induced cancer from exposures to DU on the battlefield. Part II dealt with the risks from the chemical toxicity of uranium, non-malignant radiation effects from DU intakes, the long-term environmental consequences of the deployment of DU munitions and responses to part I including issues arising at a public meeting to discuss the part I report.

Remediation of soils contaminated with particulate depleted uranium by multi stage chemical extraction.

PubMed

Crean, Daniel E; Livens, Francis R; Sajih, Mustafa; Stennett, Martin C; Grolimund, Daniel; Borca, Camelia N; Hyatt, Neil C

2013-12-15

Contamination of soils with depleted uranium (DU) from munitions firing occurs in conflict zones and at test firing sites. This study reports the development of a chemical extraction methodology for remediation of soils contaminated with particulate DU. Uranium phases in soils from two sites at a UK firing range, MOD Eskmeals, were characterised by electron microscopy and sequential extraction. Uranium rich particles with characteristic spherical morphologies were observed in soils, consistent with other instances of DU munitions contamination. Batch extraction efficiencies for aqueous ammonium bicarbonate (42-50% total DU extracted), citric acid (30-42% total DU) and sulphuric acid (13-19% total DU) were evaluated. Characterisation of residues from bicarbonate-treated soils by synchrotron microfocus X-ray diffraction and X-ray absorption spectroscopy revealed partially leached U(IV)-oxide particles and some secondary uranyl-carbonate phases. Based on these data, a multi-stage extraction scheme was developed utilising leaching in ammonium bicarbonate followed by citric acid to dissolve secondary carbonate species. Site specific U extraction was improved to 68-87% total U by the application of this methodology, potentially providing a route to efficient DU decontamination using low cost, environmentally compatible reagents. Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.

STUDIES ON THE ABSOLUTE AGE OF URANIFEROUS MINERALS OF KATANGA AND NORTHERN RHODESIA (in French)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cahen, L.; Pasteels, P.; Ledent, D.

1961-01-01

The position of the U mineralizations in the Katanga stratigraphical column is discussed. It is shown that the major phase of folding postdates all or nearly all the Katanga succession, the powerful thrusting of the Katanga belt postdates the major folding, and most of the U occurrences are younger than the turusting or the folding and are thus posttectonic. The Rhodesian specimens available for study are described. The disseminated U mineralization of the specimens is shown to be epigenetic and posttectonic. This is corfirmed by the geochronological results. Results of chemical and isotopic analysis are discussed. It is concluded thatmore » there are two distinct mineralizations dated at 520 plus or minus 20 and 520 plus or minus 20 m.y. Secondary pftchblende veins in N. Rhodesia are approxr-mately dated at 365 plus or minus 40 and 235 plus or minus 35 m.y. (A.G.W.)« less

238,234U contents on Lepomis Cyanellus from San Marcos dam located in a uraniferous area

NASA Astrophysics Data System (ADS)

Lares, Magaly Cabral; Luna-Porres, Mayra Y.; Montero-Cabrera, María E.; Renteria-Villalobos, Marusia

2014-07-01

Fish species are suitable biomonitors of radioisotopes in aquatic systems. In the present study, it was made the determination of uranium isotopic contents on fish fillet (Lepomis Cyanellus) from San Marcos dam which is located in uranium mineralized zone. Uranium activity concentrations (AC) in fish samples were obtained on wet weight (ww), using liquid scintillation. 238U and 234U AC in fish fillet ranged from 0.0004 to 0.0167 Bq kg-1, and from 0.0013 to 0.0394 Bq kg-1, respectively. The activity ratio (234U/overflow="scroll">238U) in fish fillet ranged from 2.2 to 8.8. Lepomis cyanellus from San Marcos dam shows bioaccumulation factor (FB) of 0.6 L kg-1. The results suggest that the Lepomis Cyanellus in environments with high U contents tends to have a greater bioaccumulation compared to others.

Indian Creek uranium prospects, Beaver County, Utah

USGS Publications Warehouse

Wyant, Donald G.; Stugard, Frederick

1951-01-01

The secondary uranium minerals metatorbernite (?) and autunite (?) were discovered at Indian Creek in the spring of 1950. The deposits, in sec. 26, T. 27 S., R. 6 T., Beaver County, Utah, are 20 miles west of Marysvale, and about three-eighths of a mile east of a quartz monzonite stock. The uranium minerals are sparsely disseminated in argillized and silicified earlier Tertiary Bullion Canyon latite and related volcanic rock beneart, but close to, the contact of the overlying later Tertiary Mount Belknap gray rhyolite. The prospects are in a landslide area where exposures are scarce. Therefore, trend and possible continuity of the altered and the uraniferous zones cannot be established definitely. The occurrence of secondary uranium minerals in beidellite-montmorillonite rock, formed by alteration of earlier Tertiary rocks near a quartz monzonite stock, is similar to that in some of the deposits in the Marysvale uranium district.

Physical exploration for uranium during 1951 in the Silver Reef district, Washington County, Utah

USGS Publications Warehouse

Stugard, Frederick

1953-01-01

During 1951 a joint exploration program of the most promising uraniferous areas in the Silver Reef district was made by the U.S. Geological Survey and the u.S. Atomic Energy Commission.  A U.S. Bureau of Mines drill crew, on contract to the Atomic Energy Commission, did 2,450 feet of diamond drilling under the geological supervision of the U.S. Geological Survey.  The purpose of the drilling was to delineate broadly the favorable ground for commercial development of the uranium depostis.  Ten drill holes were located around Pumpkin Point, which is the northeastern end of Buckeye Reef, to probe for extensions of small ore shootsmined on the Point in fine-grained sandstones of the Chinle formation.  Three additional holes were located around teh Tecumseh Hill to prbe for extensions of the small showings of uranium-bearing rocks of Buckeye Reef.

Preliminary experiments on the reduction of the uranyl ion to uraninite by carbonaceous substances

USGS Publications Warehouse

Breger, Irving A.; Moore, Richard T.

1955-01-01

An aqueous solution of uranyl sulfate containing a suspension of subbituminous coal has been heated at 210 C for three days. Examination of the coal at the end of the experiment showed it to contain 31.8 percent uranium recognizable as uraninite by a sharp, strong X-ray diffraction pattern. A similar experiment with degraded spruce wood also led to the formation of uraninite but in lesser quantity and with broader lines in the X-ray diffraction pattern. The ability of coal or wood to reduce the uranyl ion is a critical factor in the correlation of studies of uraniferous coals containing the uranyl ion with studies of uraninite-bearing coalified wood from the Colorado Plateau. Although these results are based an preliminary experiments, they are extremely important geochemically and warrant the development of the series of controlled studies that are proposed.

Information non précise sur la taille du pénis en République Démocratique du Congo: à propos de 21 sources

PubMed Central

Mulenga, Philippe Cilundika; Kazadi, Alex Bukasa

2016-01-01

Introduction La taille du pénis constitue une préoccupation de beaucoup des gens actuellement et certains ne sont pas satisfaits de la dimension de leur pénis comme le montre l’étude de Tiggemann en 2008. Il existe relativement peu d'études sur le pénis en érection. Cela peut refléter les tabous culturels des chercheurs ou des médecins en interaction avec les hommes qui sont dans un état d’excitation sexuelle. Toutes fois, il est important pour les personnes qui annoncent des détails sur la taille du pénis d’annoncer d’abord les repères de la mesure du pénis puis ensuite donner les chiffres que proposent les chercheurs. Méthodes Notre enquête de type descriptif transversale s’est effectuée dans les deux grandes villes de la République Démocratique du Congo à savoir la ville de Kinshasa et la ville de Lubumbashi, pendant une période de deux ans soit de Mai 2014 à Mai 2016. Au total, 21 sources d’information ont constitué notre échantillon dont 8 à Kinshasa et 13 à Lubumbashi et nous avons trouvé cela suffisant car les sujets à caractère sexuel sont souvent rares chez nous. Les paramètres étudiés étaient: la nature de la source, la précision de la technique de la mesure, la présence de référence bibliographique, la longueur annoncée du pénis. Résultats La majorité des sources d’information sont faites des émissions de radio et de télévision (23,8%), ceci pourra s’expliquer par le fait que dans notre milieu il y a de plus en plus des chaines de radio et télévision et surtout dans les grandes villes. Concernant la précision de la technique de la mesure du pénis lors du partage du message sur la taille du pénis, l’étude nous montre que la majorité des sources d’information ne signale pas cela lorsqu’elles annoncent la taille du pénis au public soit 85,7%. Plusieurs sources ne déclarent pas les références bibliographiques (57,1%). Lorsqu’on regarde même les chiffres de la taille du pénis annoncée, l’on voit les proportions majoritaires suivantes: 14 cm comme taille normale soit 28,6%, suivi de ceux là qui disent 15 cm soit 23,8% et de 15 à 20 cm soit 19%. Conclusion Ces résultats sont une interpellation des tous les acteurs responsables de la diffusion de l’information sur la santé sexuelle (taille du pénis): la rigueur scientifique consiste à chercher l’information dans des sources fiables. PMID:28154646

Identification des parametres du moteur de l'avion Cessna Citation X pour la phase de croisiere a partir des tests en vol et a base des reseaux de neurones =

NASA Astrophysics Data System (ADS)

Zaag, Mahdi

La disponibilite des modeles precis des avions est parmi les elements cles permettant d'assurer leurs ameliorations. Ces modeles servent a ameliorer les commandes de vol et de concevoir de nouveaux systemes aerodynamiques pour la conception des ailes deformables des avions. Ce projet consiste a concevoir un systeme d'identification de certains parametres du modele du moteur de l'avion d'affaires americain Cessna Citation X pour la phase de croisiere a partir des essais en vol. Ces essais ont ete effectues sur le simulateur de vol concu et fabrique par CAE Inc. qui possede le niveau D de la dynamique de vol. En effet, le niveau D est le plus haut niveau de precision donne par l'autorite federale de reglementation FAA de l'aviation civile aux Etats-Unis. Une methodologie basee sur les reseaux de neurones optimises a l'aide d'un algorithme intitule le "grand deluge etendu" est utilisee dans la conception de ce systeme d'identification. Plusieurs tests de vol pour differentes altitudes et differents nombres de Mach ont ete realises afin de s'en servir comme bases de donnees pour l'apprentissage des reseaux de neurones. La validation de ce modele a ete realisee a l'aide des donnees du simulateur. Malgre la nonlinearite et la complexite du systeme, les parametres du moteur ont ete tres bien predits pour une enveloppe de vol determinee. Ce modele estime pourrait etre utilise pour des analyses de fonctionnement du moteur et pourrait assurer le controle de l'avion pendant cette phase de croisiere. L'identification des parametres du moteur pourrait etre realisee aussi pour les autres phases de montee et de descente afin d'obtenir son modele complet pour toute l'enveloppe du vol de l'avion Cessna Citation X (montee, croisiere, descente). Cette methode employee dans ce travail pourrait aussi etre efficace pour realiser un modele pour l'identification des coefficients aerodynamiques du meme avion a partir toujours des essais en vol. None None None

Prévention de la transmission mère-enfant du VIH/sida au Bénin: le consentement des femmes au dépistage est-il libre et éclairé ?

PubMed Central

Kêdoté, N.M.; Brousselle, A.; Champagne, F.; Laudy, D.

2016-01-01

Résumé Introduction Dans les politiques internationales et nationales sur le VIH/sida, le consentement libre et éclairé est reconnu comme une composante essentielle des programmes de dépistage. Le consentement libre et éclairé implique pour les femmes enceintes d’obtenir des informations sur le programme de prévention de la transmission du VIH de la mère à l’enfant (PTME), de les comprendre et de faire un choix autonome après avoir évalué les risques et avantages. Cependant, aucune évaluation du programme de PTME ne s’est intéressée au consentement. L’objectif de cet article est d’explorer le caractère libre et éclairé du consentement des femmes enceintes quant au dépistage et à leurs motivations à faire le test. Méthode Nous avons utilisé des données récoltées dans le cadre d’une analyse d’implantation du programme de PTME au Bénin. Cette analyse s’appuie sur un devis d’étude de cas multiples incluant six maternités choisies parmi les 56 sites fonctionnels. Spécifiquement pour l’analyse du consentement, nous avons associé les données provenant d’une enquête à celles d’une recherche qualitative. Résultats Hormis trois cas de dépistage à l’insu, le caractère volontaire du consentement au test est respecté sur les sites de PTME. Vingt-neuf cas de refus ont été identifiés. Les raisons les plus souvent évoquées par les femmes enceintes sont la peur du résultat positif et de ses conséquences sur la vie familiale dans 55,2 % des cas et l’attente de l’accord ou du désaccord du mari dans 27,6 % des cas. Si globalement le consentement a été volontaire sur tous les sites, son caractère éclairé est moins probant. PMID:27840660

Capstone Depleted Uranium Aerosol Biokinetics, Concentrations, and Doses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guilmette, Raymond A.; Miller, Guthrie; Parkhurst, MaryAnn

2009-02-26

One of the principal goals of the Capstone Depleted Uranium (DU) Aerosol Study was to quantify and characterize DU aerosols generated inside armored vehicles by perforation with a DU penetrator. This study consequently produced a database in which the DU aerosol source terms were specified both physically and chemically for a variety of penetrator-impact geometries and conditions. These source terms were used to calculate radiation doses and uranium concentrations for various scenarios as part of the Capstone DU Human Health Risk Assessment (HHRA). This paper describes the scenario-related biokinetics of uranium, and summarizes intakes, chemical concentrations to the organs, andmore » E(50) and HT(50) for organs and tissues based on exposure scenarios for personnel in vehicles at the time of perforation as well as for first responders. For a given exposure scenario (duration time and breathing rates), the range of DU intakes among the target vehicles and shots was not large, about a factor of 10, with the lowest being from a ventilated operational Abrams tank and the highest being for an unventilated Abrams with DU penetrator perforating DU armor. The ranges of committed effective doses were more scenario-dependent than were intakes. For example, the largest range, a factor of 20, was shown for scenario A, a 1-min exposure, whereas, the range was only a factor of two for the first-responder scenario (E). In general, the committed effective doses were found to be in the tens of mSv. The risks ascribed to these doses are discussed separately.« less

Licochalcone-A Induces Intrinsic and Extrinsic Apoptosis via ERK1/2 and p38 Phosphorylation-mediated TRAIL Expression in Head and Neck Squamous Carcinoma FaDu Cells

PubMed Central

Park, Mi-Ra; Kim, Su-Gwan; Cho, In-A; Oh, Dahye; Kang, Kyeong-Rok; Lee, Sook-Young; Moon, Sung-Min; Cho, Seung Sik; Yoon, Goo; Kim, Chun Sung; Oh, Ji-Su; You, Jae-Seek; Kim, Do Kyung; Seo, Yo-Seob; Im, Hee-Jeong; Kim, Jae-Sung

2015-01-01

We investigated Licochalcone-A (Lico-A)-induced apoptosis and the pathway underlying its activity in a pharyngeal squamous carcinoma FaDu cell line. Lico-A purified from root of Glycyrrhiza inflata had cytotoxic effects, significantly increasing cell death in FaDu cells. Using a cell viability assay, we determined that the IC50 value of Lico-A in FaDu cells was approximately 100 µM. Chromatin condensation was observed in FaDu cells treated with Lico-A for 24 h. Consistent with this finding, the number of apoptotic cells increased in a time-dependent manner when FaDu cells were treated with Lico-A. TRAIL was significantly up-regulated in Lico-A-treated FaDu cells in a dose-dependent manner. Apoptotic factors such as caspases and PARP polymerase were subsequently activated in a caspase-dependent manner. In addition, levels of pro-apoptotic factors increased significantly in response to Lico-A treatment, while levels of anti-apoptotic factors decreased. Lico-A-induced TRAIL expression was mediated in part by a MAPK signaling pathway involving ERK1/2 and p38. Lastly, in an in vivo xenograft mouse model, Lico-A treatment effectively suppressed the growth of FaDu cell xenografts by activating caspase-3, without affecting the body weight of mice. Taken together, these data suggest that Lico-A has potential chemopreventive effects and should therefore be developed as a chemotherapeutic agent for pharyngeal squamous carcinoma. PMID:25572524

Model-dependence of neutrino emissivities and neutrino luminosities of neutron stars from the direct Urca processes and the modified Urca processes

NASA Astrophysics Data System (ADS)

Yin, Peng; Fan, Xiaohua; Dong, Jianmin; Guo, Wenmei; Zuo, Wei

2017-05-01

The neutrino emissivities in β-stable neutron star matter from the direct Urca (DU) processes and the modified Urca (MU) processes have been investigated by adopting 26 Skyrme interactions. Several physical quantities related to the MU processes and the DU processes have been calculated and discussed. The model-dependence of the neutrino emissivities from the DU processes is found to stem mainly from the model-dependence of the effective mass, while the neutrino emissivities from the MU processes are determined by the competition between the effects of the symmetry energy and the effective mass. Besides, we have investigated the total neutrino luminosities of neutron stars, with the masses of 1.2 , 1.4 , 1.6 and 1.8M⊙, from the DU processes and the MU processes. The neutrino luminosity of a neutron star is found to be primarily determined by whether the electron DU process is allowed or not. As long as the electron DU process can occur, the total luminosity turns out to be 5 to 8 orders of magnitude larger as compared with the case that the DU process is forbidden, which indicates that the strongest model-dependence of the neutrino luminosity comes from that of the symmetry energy and the equation of state (EOS) of neutron star matter. In the case that the DU processes are allowed, the discrepancy of the calculated neutrino luminosity using various Skyrme interactions remains noticeable, which is essentially attributed to the model-dependence of the symmetry energy, the EOS of NS matter and the effective masses.

GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fiorentini, Chiara; Bodei, Serena; Bedussi, Francesca

2014-04-15

Non-metastatic glycoprotein melanoma protein B (GPNMB), also known as osteoactivin (OA) is expressed in a wide array of tumors and represents an emerging target for drug development. In this study, we investigated the role of GPNMB/OA in the progression of human metastatic DU145 and PC3 prostate cancer cells. GPNMB/OA contribution in PCa malignant phenotype has been analyzed by small interfering RNA-induced GPNMB/OA silencing. We found that following GPNMB/OA silencing the migration capability of both DU145 and PC3 cells, evaluated by using in vitro invasivity assay, as well as the metalloproteinases MMP-2 and MMP-9 activity were equally strongly inhibited. By contrastmore » knocking down GPNMB/OA weakly attenuated cell proliferation rate of DU145, an effect that paralleled with an increase number of apoptotic cells. However, PC3 cell growth seems to be not affected by GPNMB/OA. Together, these data reveal that GPNMB/OA acts as a critical molecular mediator promoting the acquisition of the more aggressive, pro-metastatic phenotype distinctive of human DU145 and PC3 cell lines. - Highlights: • GPNMB/OA expression correlates with DU145 and PC3 cells malignant phenotype. • GPNMB/OA silencing affects the migration capability of both DU145 and PC3 cells. • GPNMB/OA increases invasiveness by up-regulating MMPs activity. • GPNMB/OA promotes DU145 and PC3 cells progression into a more aggressive phenotype.« less

Therapeutic Effect of Duck Interferon-Alpha Against H5N1 Highly Pathogenic Avian Influenza Virus Infection in Peking Ducks.

PubMed

Gao, Pei; Xiang, Bin; Li, Yulian; Li, Yaling; Sun, Minhua; Kang, Yinfeng; Xie, Peng; Chen, Libin; Lin, Qiuyan; Liao, Ming; Ren, Tao

2018-04-01

The antiviral cytokine interferon-alpha (IFN-α) plays a critical role in the innate immune system. Previous studies have shown that recombinant chicken IFN-α inhibits avian influenza virus (AIV) replication in vivo; however, the antiviral effect of recombinant duck IFN-α (rDuIFN-α) on highly pathogenic AIV remains unknown. In this study, the duck IFN-α gene was cloned, expressed, and purified. The antiviral effects of the resulting rDuIFN-α were further evaluated in vitro and in vivo. Our results showed that rDuIFN-α inhibited the replication of vesicular stomatitis virus (VSV) and AIV in duck embryo fibroblasts in vitro, with antiviral activities against VSV and AIV of 2.1 × 10 5 and 4.1 × 10 5 U/mg, respectively. We next investigated the anti-H5N1 AIV effect of intramuscular injection of rDuIFN-α in vivo. rDuIFN-α reduced viral titers in the brains, lungs, and spleens of 2-day-old (2D) ducks compared with that in the virus-challenged control group, and pretreatment with rDuIFN-α reduced mortality from 60% to 10% in 2D ducks. Moreover, rDuIFN-α increased the expression of IFN-stimulated genes in the brains and spleens of 2D ducks. Our results demonstrate that rDuIFN-α blocks VSV and H5N1 influenza virus infection in vitro and exhibits antiviral effects against H5N1 influenza virus infection in 2D ducks.

History of Cern

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2007-12-20

Cérémonie à l'occasion de l'apparition du premier volume du livre sur l'histoire du Cern, avec plusieurs personnes présentes qui jouaient un rôle important dans cette organisation européenne couronnée de succès grâce à l'esprit des membres fondateurs qui est et restera essentiel

Locke and Du Bois: Two Major Black Voices Muzzled by Philanthropic Organizations.

ERIC Educational Resources Information Center

Fitchue, M. Anthony

1997-01-01

In 1935, the Howard University philosopher Alain Locke asked W. E. B. Du Bois to contribute to an adult education project for African Americans. Censorship by white-controlled foundations forced Locke to reject the Du Bois essay to protect contributions for causes of great importance to blacks. (Author/SLD)

Le kyste hydatique du cordon spermatique: une localisation exceptionnelle

PubMed Central

Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

2011-01-01

L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique. PMID:22384304

Processing of next generation weather radar-multisensor precipitation estimates and quantitative precipitation forecast data for the DuPage County streamflow simulation system

USGS Publications Warehouse

Bera, Maitreyee; Ortel, Terry W.

2018-01-12

The U.S. Geological Survey, in cooperation with DuPage County Stormwater Management Department, is testing a near real-time streamflow simulation system that assists in the management and operation of reservoirs and other flood-control structures in the Salt Creek and West Branch DuPage River drainage basins in DuPage County, Illinois. As part of this effort, the U.S. Geological Survey maintains a database of hourly meteorological and hydrologic data for use in this near real-time streamflow simulation system. Among these data are next generation weather radar-multisensor precipitation estimates and quantitative precipitation forecast data, which are retrieved from the North Central River Forecasting Center of the National Weather Service. The DuPage County streamflow simulation system uses these quantitative precipitation forecast data to create streamflow predictions for the two simulated drainage basins. This report discusses in detail how these data are processed for inclusion in the Watershed Data Management files used in the streamflow simulation system for the Salt Creek and West Branch DuPage River drainage basins.

Dedicated Caravan Sites for French Gens du Voyage: Public Health Policy or Construction of Health and Environmental Inequalities?

PubMed

Foisneau, Lise

2017-12-01

In France, gens du voyage ("people who travel" or "travellers") is a term used by the government to categorize various itinerant populations, the majority of which are diverse Romani groups. People categorized as gens du voyage are legally required to reside in particular locations called "dedicated caravan sites." Parliamentary debates about these dedicated caravan sites have clarified that one of the objectives of such sites is to help fulfill the gens du voyage 's right to health. However, there is a significant gap between the officially stated goals of such sites and the reality of life within them. This paper draws on research finding that the conditions in most dedicated caravan sites do not conform with the rights of gens du voyage to acceptable sanitary conditions and other underlying determinants of health.

Dedicated Caravan Sites for French Gens du Voyage

PubMed Central

2017-01-01

Abstract In France, gens du voyage (“people who travel” or “travellers”) is a term used by the government to categorize various itinerant populations, the majority of which are diverse Romani groups. People categorized as gens du voyage are legally required to reside in particular locations called “dedicated caravan sites.” Parliamentary debates about these dedicated caravan sites have clarified that one of the objectives of such sites is to help fulfill the gens du voyage’s right to health. However, there is a significant gap between the officially stated goals of such sites and the reality of life within them. This paper draws on research finding that the conditions in most dedicated caravan sites do not conform with the rights of gens du voyage to acceptable sanitary conditions and other underlying determinants of health. PMID:29302165

Physicochemical characterization of Capstone depleted uranium aerosols III: morphologic and chemical oxide analyses.

PubMed

Krupka, Kenneth M; Parkhurst, Mary Ann; Gold, Kenneth; Arey, Bruce W; Jenson, Evan D; Guilmette, Raymond A

2009-03-01

The impact of depleted uranium (DU) penetrators against an armored target causes erosion and fragmentation of the penetrators, the extent of which is dependent on the thickness and material composition of the target. Vigorous oxidation of the DU particles and fragments creates an aerosol of DU oxide particles and DU particle agglomerations combined with target materials. Aerosols from the Capstone DU aerosol study, in which vehicles were perforated by DU penetrators, were evaluated for their oxidation states using x-ray diffraction (XRD), and particle morphologies were examined using scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS). The oxidation state of a DU aerosol is important as it offers a clue to its solubility in lung fluids. The XRD analysis showed that the aerosols evaluated were a combination primarily of U3O8 (insoluble) and UO3 (relatively more soluble) phases, though intermediate phases resembling U4O9 and other oxides were prominent in some samples. Analysis of particle residues in the micrometer-size range by SEM/EDS provided microstructural information such as phase composition and distribution, fracture morphology, size distribution, and material homogeneity. Observations from SEM analysis show a wide variability in the shapes of the DU particles. Some of the larger particles were spherical, occasionally with dendritic or lobed surface structures. Others appear to have fractures that perhaps resulted from abrasion and comminution, or shear bands that developed from plastic deformation of the DU material. Amorphous conglomerates containing metals other than uranium were also common, especially with the smallest particle sizes. A few samples seemed to contain small bits of nearly pure uranium metal, which were verified by EDS to have a higher uranium content exceeding that expected for uranium oxides. Results of the XRD and SEM/EDS analyses were used in other studies described in this issue of Health Physics to interpret the results of lung solubility studies and in selecting input parameters for dose assessments.

[Dépistage précoce des retards du développement moteur: Outil de dépistage axé sur la famille].

PubMed

Harris, Susan R

2016-08-01

Décrire le test HINT (Harris Infant Neuromotor Test), un test d'évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s'appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. QUALITÉ DES DONNÉES: D'abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu'évaluées par le test HINT. La plupart des données probantes sont de niveau II. Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Seul le dépistage précoce des retards du développement moteur, initialement par l'entremise d'outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l'enfant qu'à sa famille. Copyright© the College of Family Physicians of Canada.

Differential Efficacy of Combined Therapy With Radiation and AEE788 in High and Low EGFR-Expressing Androgen-Independent Prostate Tumor Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huamani, Jessica; Willey, Christopher; Thotala, Dinesh

2008-05-01

Purpose: To determine the efficacy of combining radiation (XRT) with a dual epidermal growth factor receptor (EGFR)/vascular endothelial growth factor receptor inhibitor, AEE788, in prostate cancer models with different levels of EGFR expression. Methods and Materials: Immunoblotting was performed for EGFR, phosphorylated-EGFR, and phosphorylated-AKT in prostate cancer cells. Clonogenic assays were performed on DU145, PC-3, and human umbilical vein endothelial cells treated with XRT {+-} AEE788. Tumor xenografts were established for DU145 and PC-3 on hind limbs of athymic nude mice assigned to four treatment groups: (1) control, (2) AEE788, (3) XRT, and (4) AEE788 + XRT. Tumor blood flowmore » and growth measurements were performed using immunohistochemistry and imaging. Results: AEE788 effectively decreased phosphorylated-EGFR and phosphorylated-AKT levels in DU145 and PC-3 cells. Clonogenic assays showed no radiosensitization for DU145 and PC-3 colonies treated with AEE788 + XRT. However, AEE788 caused decreased proliferation in DU145 cells. AEE788 showed a radiosensitization effect in human umbilical vein endothelial cells and increased apoptosis susceptibility. Concurrent AEE788 + XRT compared with either alone led to significant tumor growth delay in DU145 tumors. Conversely, PC-3 tumors derived no added benefit from combined-modality therapy. In DU145 tumors, a significant decrease in tumor blood flow with combination therapy was shown by using power Doppler sonography and tumor blood vessel destruction on immunohistochemistry. Maldi-spectrometry (MS) imaging showed that AEE788 is bioavailable and heterogeneously distributed in DU145 tumors undergoing therapy. Conclusions: AEE788 + XRT showed efficacy in vitro/in vivo with DU145-based cell models, whereas PC-3-based models were adequately treated with XRT alone without added benefit from combination therapy. These findings correlated with differences in EGFR expression and showed effects on both tumor cell proliferation and vascular destruction.« less

World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek

USGS Publications Warehouse

Labay, Keith A.; Wilson, Frederic H.

2004-01-01

The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

Dépistage précoce des retards du développement moteur

PubMed Central

Harris, Susan R.

2016-01-01

Résumé Objectif Décrire le test HINT (Harris Infant Neuromotor Test), un test d’évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s’appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. Qualité des données D’abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu’évaluées par le test HINT. La plupart des données probantes sont de niveau II. Message principal Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Conclusion Seul le dépistage précoce des retards du développement moteur, initialement par l’entremise d’outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l’enfant qu’à sa famille. PMID:27521405

Les masques trompeurs de la bipolarité: étude de 100 cas

PubMed Central

Nabih, Fadoua Oueriagli; Benali, Abdesslam; Adali, Imane; Manoudi, Fatiha; Asri, Fatima

2015-01-01

Le trouble bipolaire (TB) est une pathologie dont la prévalence est estimée à 1-2%. Le diagnostic précoce du trouble constitue un enjeu thérapeutique majeur. L'objectif de ce travail est de déterminer les différents diagnostiques attribués aux patients bipolaires avant de recevoir le diagnostic adéquat et de préciser le délai moyen du retard diagnostique. C'est une étude descriptive transversale portant sur 100 patients atteints de TB, inclus selon les critères du DSM V, qui ont été vus en consultation ou bien hospitalisés dans le service de psychiatrie de l'hôpital Militaire Avicenne de Marrakech, durant une période de deux ans. L’âge moyen des patients était de 29,5 ans avec une prédominance masculine (80%). 40% de nos patients ont reçu au début un autre diagnostic que celui du TB et le premier diagnostic retenu était celui de l’épisode dépressif majeur dans 36% des cas, suivi de l'accès psychotique aigu dans 28% des cas, la schizophrénie dans 16,8% et le trouble de personnalité dans 10,2%. Le délai moyen du retard diagnostic était de 64 mois. 50% des patients ayant reçu un autre diagnostic avaient consulté au moins un psychiatre et 60% des patients avaient été hospitalisés au moins une fois avant le diagnostic du TB. Les errances diagnostiques du TB sont bien établies, conduisant forcément à un retard de prise en charge adéquate. Ces données devraient alerter les psychiatres pour favoriser un meilleur dépistage de la manie et de l'hypomanie qui restent les éléments clé du diagnostic du TB. PMID:26587161

Resilience of Critical Infrastructure to Extreme Fires - Gaps and Challenges

DTIC Science & Technology

2014-04-01

du Canada), telle que représentée par le ministre de la Défense nationale, 2014 3 Abstract …….. This report provides the results of the study...the results of the two fire tests. Résumé …..... Le présent rapport fournit les résultats de l’étude menée par le Conseil national de recherches du...d’entreposage de carburants ou de véhicule-citerne. L’effondrement des tours du World Trade Centre, le 11 septembre 2001, et celui de l’échangeur du pont

DRDC Toronto Technical Stream Integrated Capabilities and Vision

DTIC Science & Technology

2011-09-01

du RT, et les présenter à la séance d’information 2010 destinée à tout le personnel, puis à la réunion du Comité de gestion . Reposant sur une...profession technique, c) adoption d’une culture de collaboration et de réseautage, d ) élargissement de l’influence de la profession technique. Grâce à...d’information 2010 destinée à tout le personnel, puis à la réunion du Comité de gestion . Résultats : Une équipe de projet, composée de huit membres du

Localisation inhabituelle de la tuberculose: ostéoarthrite tuberculose du pouce

PubMed Central

Mortaji, Aziz; Koulali, Khalid; Galuia, Farid

2014-01-01

L'ostéoarthrite tuberculose est rare au niveau des doigts. Nous rapportons une observation d'atteinte du pouce chez un patient de 55 ans. Il avait présenté une tuméfaction douloureuse du pouce droit suite à un traumatisme du pouce. L’étude bactériologique et une biopsie avaient permis de confirmer le diagnostic. Un traitement antibacillaire de 12 mois avait donné des résultats satisfaisants. Les particularités de la prise en charge sont discutées par rapport aux données de la littérature. PMID:25932075

Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins.

PubMed Central

Bayer, A S; Ramos, M D; Menzies, B E; Yeaman, M R; Shen, A J; Cheung, A L

1997-01-01

Staphylococcal alpha-toxin targets several cell types which are important components of cardiac vegetations in endocarditis, including platelets, erythrocytes, and endothelial cells. We evaluated the in vivo role of Staphylococcus aureus alpha-toxin in experimental endocarditis by using isogenic strains differing in the capacity to produce functional alpha-toxin, including 8325-4 (wild-type strain), DU-1090 (a mutant strain with allelic replacement of the alpha-toxin gene [hla]), DU1090(pH35L) (a mutant strain producing a target cell-binding but nonlytic toxin), DU1090(pDU1212) (a variant of DU1090 carrying the cloned hla gene on a multicopy plasmid), and DU1090(pCL84::hla) (a variant of DU1090 with a single copy of the hla gene cloned into the chromosomal lipase locus). In vitro, wild-type alpha-toxin (from parental strain 8325-4) extensively lysed both erythrocytes and platelets. In contrast, mutant alpha-toxin [from strain DU1090(pH35L)] lysed neither cell type. Following exposure to the wild-type alpha-toxin, platelet lysates were found to contain microbicidal activity against Bacillus subtilis (but not against Micrococcus luteus), as well as against the parental and alpha-toxin variant S. aureus strains noted above. Furthermore, lysate microbicidal activity was heat stable, neutralized by polyanionic filters or compounds, and recoverable from anionic filter membranes by hypertonic saline elution. These characteristics are consistent with those of cationic platelet microbicidal proteins (PMPs). Reverse-phase high-pressure liquid chromatography and polyacrylamide gel electrophoresis confirmed the presence of three distinct PMPs (1, 2, and 3) in platelet lysates. In experimental endocarditis, the two variant staphylococcal strains producing either minimal alpha-toxin or nonlytic alpha-toxin in vitro [strains DU1090 and DU1090(pH35L), respectively] exhibited significantly lower virulence in vivo than the parental strain (decreased intravegetation staphylococcal densities). Paradoxically, the two variant staphylococcal strains producing alpha-toxin at supraparental levels in vitro [strains DU1090(p1212) and DU1090(pCL84::hla)] also exhibited significantly decreased induction rates and intravegetation staphylococcal densities in experimental endocarditis versus the parental strain. The reduced in vivo virulence of the latter variant staphylococcal strains could not be explained by differences in bacteremic clearance or initial adherence to sterile vegetations (compared to the parental strain). These findings suggest that the reduced virulence exhibited by the variant staphylococcal strains in this model was related to pathogenetic events subsequent to bacterial adherence to the damaged endocardium. Excess intravegetation secretion of alpha-toxin, leading to increased PMP release (secondary to either increased platelet secretion or lysis), may well explain the reduced virulence observed in experimental endocarditis. PMID:9353046

Effects of depleted uranium on survival, growth, and metamorphosis in the african clawed frog (Xenopus laevis)

USGS Publications Warehouse

Mitchell, S.E.; Caldwell, C.A.; Gonzales, G.; Gould, W.R.; Arimoto, R.

2005-01-01

Embryos (stage 8-47, Nieuwkoop and Faber) of the African clawed frog (Xenopus laevis) were subjected to water-borne depleted uranium (DU) concentrations that ranged from 4.8 to 77.7 mg/Lusing an acute 96-h frog embryo teratogenesis assay-Xenopus (FETAX). In a chronic 64-d assay, X. laevis (from embryo through metamorphosis; stages 8-66) were subjected to concentrations of DU that ranged from 6.2 to 54.3 mg/L Our results indicate DU is a non teratogenic metal. No effects on mortality, malformations, or growth were observed in the 96-h FETAX with concentrations of DU that ranged from 4.8 to 77.7 mg/L From stage 8 to stage 47, X. laevis tadpoles do not actively feed and the gills are not well developed. Thus, uptake of DU was reduced despite exposure to elevated concentrations. The 64-d assay resulted in no concentration response for either mortality or malformations; however, a delay in metamorphosis was observed in tadpoles subjected to elevated DU concentrations (from 13.1 to 54.3 mg/L) compared to tadpoles in both the well-water control and reference. The delay in metamorphosis was likely due to increasing body burden of DU that ranged from 0.98 to 2.82 mg/kg. Copyright?? Taylor & Francis Inc.

Identification d'une loi thermo-élasto-viscoplastique en vue de la modélisation du laminage à chaud du cuivre

NASA Astrophysics Data System (ADS)

Moureaux, P.; Moto Mpong, S.; Remy, M.; Bouffioux, C.; Lecomte-Beckers, J.; Habraken, A. M.

2002-12-01

la mise au point d'un modèle de simulation de la dernière passe du laminage à chaud du cuivre ne présente à priori pas de problème du point de vue numérique pour un code d'éléments finis non linéaire. La collecte d'informations précises tant sur le procédé industriel que sur le comportement du matériau est par contre une opération non triviale. Cet article présente les diverses méthodes expérimentales mises en œuvre pour caractériser le matériau : essais de compression à chaud, mesures d'analyse thermique différentielle, essais de dilatométrie et de diffusivité. Les méthodes permettant d'identifier les paramètres de la loi élasto-visco-plastique de type Norton-Hoff à partir des essais sont présentées et une analyse bibliographique investigue le problème de la détermination du module de Young à haute température. Tant les hypothèses supplémentaires relatives au procédé et nécessaires au modèle que les résultats finaux sont résumés.

Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickel.

PubMed

Miller, Alexandra C; Xu, Jiaquan; Stewart, Michael; Prasanna, Pataje G S; Page, Natalie

2002-02-01

Limited data exist to permit an accurate assessment of risks for carcinogenesis and mutagenesis from embedded fragments or inhaled particulates of depleted uranium (DU). Ongoing studies have been designed to provide information about the carcinogenic potential of DU using in vitro and in vivo assessments of morphological transformation as well as cytogenetic, mutagenic, and oncogenic effects. For comparison, we also examined tungsten alloys used in military projectiles and the known carcinogen nickel. Quantitative and qualitative in vitro transformation studies were done to assess the carcinogenic potential of radiation and chemical hazards. Using a human osteosarcoma cell model, we demonstrated that soluble and insoluble DU compounds can transform cells to the tumorigenic phenotype, as characterized by morphological, biochemical, and oncogenic changes consistent with tumor cell behavior. Tungsten alloys and nickel were also shown to be neoplastic transforming agents, although at a frequency less than that of DU. Sister chromatid exchange, micronuclei, and alkaline filter elution assays showed DU and tungsten alloys were genotoxic. Exposure to a nontoxic, nontransforming dose of DU induced a small but statistically significant increase in the number of dicentrics formed in cells. These results suggest that long-term exposure to DU or tungsten alloys could be critical to the development of neoplastic disease in humans and that additional studies are needed.

Le cannabis et les enfants et adolescents canadiens

PubMed Central

Grant, Christina N; Bélanger, Richard E

2017-01-01

Résumé L’usage du cannabis, la drogue illicite la plus consommée dans le monde, est fréquent chez les adolescents canadiens. La consommation de cannabis à l’adolescence peut provoquer des modifications fonctionnelles et structurelles du cerveau en développement et induire une atteinte cérébrale. Dans ce groupe d’âge, la consommation de marijuana s’associe fortement à la dépendance au cannabis et à d’autres troubles de l’usage d’une substance, à l’adoption et au maintien du tabagisme, à l’augmentation des troubles de santé mentale, y compris la dépression, l’anxiété et la psychose, à une perturbation du développement neurologique et à un déclin cognitif ainsi qu’à une diminution de la performance scolaire et des réalisations au cours de la vie. Le taux de soins médicaux aigus et d’hospitalisations chez les jeunes enfants qui ont consommé involontairement du cannabis est en hausse. Compte tenu du débat en cours sur la réglementation du cannabis au Canada, l’examen attentif des preuves de ses effets sur la santé et la mise en place de mécanismes de protection deviennent des priorités absolues en santé publique.

Risk and protective factors for psychological distress among adolescents: a family study in the Nord-Trøndelag Health Study.

PubMed

Myklestad, Ingri; Røysamb, Espen; Tambs, Kristian

2012-05-01

The study aimed to investigate potential adolescent and parental psychosocial risk and protective factors for psychological distress among adolescents and, in addition, to examine potential gender and age differences in the effects of risk factors on adolescent psychological distress. Data were collected among 8,984 Norwegian adolescents (13-19 years) and their parents in the Nord-Trøndelag Health Study (HUNT). The outcome measure was psychological distress (SCL-5). Bivariate regression analysis with generalized estimating equation (GEE) model showed that all parental self-reported variables (mental distress, substance use, social network, economic problems, unemployment and family structure) and adolescents' self-reported variables (leisure activities, social support from friends, school-related problems and substance use) were significantly associated with psychological distress among adolescents. Results revealed that in a multiple regression analysis with a GEE model, adolescent psychosocial variables, specifically academic-related problems and being bullied at school, emerged as the strongest predictors of psychological distress among adolescents after controlling for age, gender, and all parental and adolescent variables. The following psychosocial risk factors were significantly more important for girl's psychological distress compared to boys: problems with academic achievement, conduct problems in school, frequency of being drunk, smoking, dissatisfaction in school, living alone and seen parents being drunk. Academic achievement and being bullied at school were the psychosocial factors most strongly associated with psychological distress among adolescents. Parental factors had an indirect effect on adolescent psychological distress, through adolescents' psychosocial factors.

Gender differences in subjective well-being, self-esteem and psychosocial functioning in adolescents with symptoms of anxiety and depression: findings from the Nord-Trøndelag Health Study.

PubMed

Derdikman-Eiron, Ruth; Indredavik, Marit S; Bratberg, Grete H; Taraldsen, Gunnar; Bakken, Inger Johanne; Colton, Matthew

2011-06-01

Gender differences in the prevalence of symptoms of anxiety and depression during adolescence are well documented. However, little attention has been given to differences in subjective well-being, self-esteem and psychosocial functioning between boys and girls with symptoms of anxiety and depression. The aim of this study was to investigate gender differences in the associations between such symptoms and subjective well-being, self-esteem, school functioning and social relations in adolescents. Data were taken from a major population-based Norwegian study, the Nord-Trøndelag Health study (HUNT), in which 8984 (91% of all invited) adolescents, aged 13-19 years, completed an extensive self-report questionnaire. Although prevalence rates of symptoms of anxiety and depression were higher in girls than in boys, a significant interaction between gender and symptoms of anxiety and depression was found in respect of each of the following outcome variables: subjective well-being, self-esteem, academic problems, frequency of meeting friends and the feeling of not having enough friends. These interactions indicate that the associations between symptoms of anxiety and depression and lower subjective well-being and self-esteem, more academic problems in school and lower social functioning were stronger for boys than for girls. Our findings may contribute to an earlier assessment and more efficient treatment of male adolescent anxiety and depression. © 2011 The Authors. Scandinavian Journal of Psychology © 2011 The Scandinavian Psychological Associations.

[From the glorious time of homeopathy medicine chests in Nord-Schleswing (South Justland) about 1900].

PubMed

Marckmann, Anton

2003-01-01

The article deals with the origin, background and development of homoeopathy over a hundred years span, beginning with its "invention" in the early 19th century (Hahnemann). Leipzig became a center for a huge production of homoeopathic remedies through Dr. W. Schwabe's "Central-Apoteke", founded in 1878, with customers all over the world. The preparation of around one thousand products were described in 1880 in Schwabes "Pharmacopoea homoeopatica polyglotta", in five languages, and this article gives a survey of the principles in the production of the final remedies which were distributed as Schwabes homoeopatic house-chests of many varieties, containing from a few up to more than hundred bottles. Detailed instructions and guidance in the applications of the content of these popular and wide-spread chests were available for laymen from hand-books. However their use vanished gradually in the third decade of the 20th century and later, and the chests were either destroyed or put away. This was also true for the situation in South Jutland (before 1920 a german province called Nord Schleswig), nevertheless the author's research succeeded in detecting thirteen homoeopathic house-chests from the region, purchased about year 1900. An attempt is made to throw light on their origin, their use and their users at a time, when homoeopathy played a role for layman in the treatment of diseases, outside the authorized health service - or as a supplement to this.

First results of Liguria-Trento transplant network project: a model for a macroregional network and real-time registry in Italy.

PubMed

Valente, R; Cambiaso, F; Santori, G; Ghirelli, R; Gianelli, A; Valente, U

2004-04-01

In Italy, health-care telematic is funded and supported at the level of national government or regional institutions. In 1999, the Italian Ministry of Health started to fund the Liguria-Trento Transplant Network (LTTN) project, a health research project with the aim to build an informative system for donor management and transplantation activity in a macroregional area. At the time of LTTN project proposal, no published Transplant Network Informative System fulfilled Italian rules on telematic management of electronic documentation concerning transplantation activity. Partnership of LTTN project were two Regional Transplant Coordinating Centres, Nord Italia Transplant Interregional Coordinating Centre and the Italian Institute of Health/National Transplant Coordinating Centre. Project Total Quality Management methods were adopted. Technological and case analysis followed ANSI-HL7, CEN-TC251, and Object-Oriented Software Engineering standards. A low-tech prototype powered by a web access relational database is running on a transplant network including web-based clients located in 17 intensive care units, in Nord Italia Transplant Interregional Coordinating Centre, and at the Italian Institute of Health/National Transplant Coordinating Centre. LTTN registry includes pretransplant, surgical, and posttransplant phases regarding liver, kidney, pancreas, and kidney-pancreas transplantation in adult and pediatric recipients. Clinical specifications were prioritized in agreement with the RAND/UCLA appropriateness method. Further implementation will include formal rules for data access and output release, fault tolerance, and a continuous registry evolution plan.

Disability in society-medical and non-medical determinants for disability pension in a Norwegian total county population study.

PubMed

Krokstad, Steinar; Westin, Steinar

2004-05-01

The objective of this study was to describe sociomedical determinants and developments for the medically based disability pension in Norway by linking individual based data from a county health survey to data on disability from the National Insurance Administration. Two cross-sectional total population health surveys with an approximate 10-year interval were conducted in Nord-Trøndelag county, HUNT I (1984-86) and HUNT II (1995-97), which allows for analyses of changes over time, supplied with official incidence data on disability pension. The large-scale variations and overall increasing incidence rates of disability pension in Norway during the last 20 years also applied to the county of Nord-Trøndelag. The prevalence of disability pension generally increased in the population from the mid-1980s to the mid-1990s. A striking finding was a consistent pattern of increasing prevalence of disability pension with decreasing socio-economic status and education. A geographic pattern for disability pension prevalence on a municipality level suggested that structural and cultural factors were important in determining the level of disability in society. Medical determinants alone cannot explain either the dramatic variations or the overall increased incidence rates of disability pension in the last two decades in Norway. The results demonstrate the importance of social, non-medical and contextual determinants for disability pension, how these determinants result in important prevalence differences by socio-economic status, and their impact on the level of disability in society.

Self-rated health and mortality in different occupational classes and income groups in Nord-Trøndelag County, Norway.

PubMed

Holseter, Christoffer; Dalen, Joakim Døving; Krokstad, Steinar; Eikemo, Terje Andreas

2015-03-10

People with a lower socioeconomic position have a higher the prevalence of most self-rated health problems. In this article we ask whether this may be attributed to self-rated health not reflecting actual health, understood as mortality, in different socioeconomic groups. For the study we used data from the Nord-Trøndelag Health Study 1984-86 (HUNT1), in which the county's entire adult population aged 20 years and above were invited to participate. The association between self-rated health and mortality in different occupational classes and income groups was analysed. The analysis corrected for age, chronic disease, functional impairment and lifestyle factors. The association between self-rated health and mortality was of the same order of magnitude for the occupational classes and income groups, but persons without work/income and with poor self-rated health stood out. Compared with persons in the highest socioeconomic class, unemployed men had a hazard ratio for death that was three times higher in the follow-up period. For women with no income, the ratio was twice as high. INTERPRETATION Self-rated health and mortality largely conform to the different socioeconomic strata. This supports the perception that socioeconomic differences in health are a reality and represent a significant challenge nationally. Our results also increase the credibility of findings from other studies that use self-reported health in surveys to measure differences and identify the mechanisms that create them.

Association between Fatigue and Autistic Symptoms in Children with Cri du Chat Syndrome

ERIC Educational Resources Information Center

Claro, Anthony; Cornish, Kim; Gruber, Reut

2011-01-01

In the current study, the authors examined whether the fatigue level of children diagnosed with cri du chat syndrome was associated with the expression of autistic symptoms. Sixty-nine children with cri du chat syndrome were compared with 47 children with moderate to severe intellectual disabilities who did not differ on intellectual severity.…

Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (13th, Quebec, Canada, March 25-26, 1999).

ERIC Educational Resources Information Center

Kavanagh, Eric, Ed.

Papers on language research in this volume include the following: Pour une comparaison des voyelles nasals du Quebec et du Haut-Jura: observations, methodologie et outils infomatiques (A Comparison of Quebec and Haut-Jura's Nasal Vowels: Observations, Methodologies, and Instrumentation) (Vincent Arnaud and Claude Paradis); Le negociation du sens…

Prevalence of Autism Spectrum Phenomenology in Cornelia de Lange and Cri du Chat Syndromes

ERIC Educational Resources Information Center

Moss, Joanna F.; Oliver, Chris; Berg, Katy; Kaur, Gurmeash; Jephcott, Lesley; Cornish, Kim

2008-01-01

Autism spectrum disorder characteristics have not been evaluated in Cornelia de Lange and Cri du Chat syndromes using robust assessments. The Autism Diagnostic Observation Schedule and Social Communication Questionnaire were administered to 34 participants with Cornelia de Lange syndrome and a comparison group of 23 participants with Cri du Chat…

Detection de la fin de la compaction des anodes par le son

NASA Astrophysics Data System (ADS)

Sanogo, Bazoumana

L'objectif de ce projet etait de developper un outil de controle en temps reel du temps de compaction en se servant du son genere par le vibrocompacteur pendant le formage des anodes crues. Ainsi, une application a ete developpee pour l'analyse des sons enregistres. Des essais ont ete realises avec differents microphones pour une meilleure qualite des mesures et un a ete choisi pour la suite du projet. De meme, differents tests ont ete realises sur des anodes de laboratoire ainsi que des anodes a l'echelle industrielle afin de mettre en place une methode pour la detection du temps optimal necessaire au formage des anodes. Les travaux au laboratoire de carbone a l'Universite du Quebec a Chicoutimi (UQAC) ont consiste a l'enregistrement de son des anodes fabriquees sur place avec differentes configurations; et a la caracterisation de certaines anodes de l'usine. Les anodes fabriquees au laboratoire sont reparties en deux groupes. Le premier regroupe les anodes pour la validation de notre methode. Ce sont des anodes produites avec des temps de compaction differents. Le laboratoire de carbone a l'UQAC est unique et il est possible de produire des anodes avec les memes proprietes que celles des anodes industrielles. Par consequent, la validation initialement prevue a l'usine a ete effectuee avec les anodes de laboratoire. Le deuxieme groupe a servi a etudier les effets des matieres premieres sur le temps de compaction. Le type de coke et le type de brai ont constitue les differentes variations dans ce deuxieme groupe. Quant aux tests et mesures a l'usine, ils ont ete realises en trois campagnes de mesure. La premiere campagne en juin 2014 a servi a standardiser et a trouver le meilleur positionnement des appareils pour les mesures, a regler le logiciel et a faire les premieres mesures. Une deuxieme campagne en mai 2015 a fait l'objet d'enregistrement de son en classant les anodes selon differents temps de compaction. La troisieme et derniere campagne en decembre 2015 a ete le lieu de tests finaux a l'usine en fabriquant des anodes avec differents criteres (variation du temps de compaction, taux de brai, arret manuel du compacteur, variation de la pression des ballons du haut du compacteur). Ces anodes ont ete ensuite analysees au laboratoire a l'UQAC. En parallele a ces travaux precites, l'amelioration de l'application d'analyse du son a ete faite avec le choix des parametres d'analyse et leur standardisation. Les resultats des premiers tests au laboratoire et ceux de la campagne de juin 2014 ont montre que la formation des anodes se fait suivant trois etapes : rearrangement des particules et du brai, compaction et consolidation et enfin la finition. Ces travaux ont montre en outre que le temps de compaction joue un role tres important dans la definition des proprietes finales des anodes. Ainsi, en plus du type de brai, du taux de brai et du type de coke, il faut tenir compte du temps de sur-compaction et de sous-compaction. En effet, ceci a ete demontre a travers les deux validations qui ont ete realisees. Les resultats de la caracterisation des echantillons (venant des anodes de la campagne de decembre 2015) ont montre qu'une anode compactee a un temps optimal acquiert une bonne resistance a la compression et sa resistivite electrique baisse. En outre, on note que le temps de compaction dans notre cas a baisse legerement avec l'augmentation de la pression des ballons de haut du vibrocompacteur. Ce qui a eu pour effet d'augmenter la densite crue de l'anode. Toutefois, il faut s'abstenir de generaliser ce constat car le nombre d'anodes testees est faible dans notre cas. Par ailleurs, cette etude montre que le temps necessaire pour le formage d'une anode croit avec l'augmentation du taux de brai et baisse legerement avec l'augmentation de la pression des ballons. (Abstract shortened by ProQuest.).

Mesure et retroaction sur un qubit multi-niveaux en electrodynamique quantique en circuit non lineair

NASA Astrophysics Data System (ADS)

Boissonneault, Maxime

L'electrodynamique quantique en circuit est une architecture prometteuse pour le calcul quantique ainsi que pour etudier l'optique quantique. Dans cette architecture, on couple un ou plusieurs qubits supraconducteurs jouant le role d'atomes a un ou plusieurs resonateurs jouant le role de cavites optiques. Dans cette these, j'etudie l'interaction entre un seul qubit supraconducteur et un seul resonateur, en permettant cependant au qubit d'avoir plus de deux niveaux et au resonateur d'avoir une non-linearite Kerr. Je m'interesse particulierement a la lecture de l'etat du qubit et a son amelioration, a la retroaction du processus de mesure sur le qubit de meme qu'a l'etude des proprietes quantiques du resonateur a l'aide du qubit. J'utilise pour ce faire un modele analytique reduit que je developpe a partir de la description complete du systeme en utilisant principalement des transfprmations unitaires et une elimination adiabatique. J'utilise aussi une librairie de calcul numerique maison permettant de simuler efficacement l'evolution du systeme complet. Je compare les predictions du modele analytique reduit et les resultats de simulations numeriques a des resultats experimentaux obtenus par l'equipe de quantronique du CEASaclay. Ces resultats sont ceux d'une spectroscopie d'un qubit supraconducteur couple a un resonateur non lineaire excite. Dans un regime de faible puissance de spectroscopie le modele reduit predit correctement la position et la largeur de la raie. La position de la raie subit les decalages de Lamb et de Stark, et sa largeur est dominee par un dephasage induit par le processus de mesure. Je montre que, pour les parametres typiques de l'electrodynamique quantique en circuit, un accord quantitatif requiert un modele en reponse non lineaire du champ intra-resonateur, tel que celui developpe. Dans un regime de forte puissance de spectroscopie, des bandes laterales apparaissent et sont causees par les fluctuations quantiques du champ electromagnetique intra-resonateur autour de sa valeur d'equilibre. Ces fluctuations sont causees par la compression du champ electromagnetique due a la non-linearite du resonateur, et l'observation de leur effet via la spectroscopie d'un qubit constitue une premiere. Suite aux succes quantitatifs du modele reduit, je montre que deux regimes de parametres ameliorent marginalement la mesure dispersive d'un qubit avec un resonateur lineaire, et significativement une mesure par bifurcation avec un resonateur non lineaire. J'explique le fonctionnement d'une mesure de qubit dans un resonateur lineaire developpee par une equipe experimentale de l'Universite de Yale. Cette mesure, qui utilise les non-linearites induites par le qubit, a une haute fidelite, mais utilise une tres haute puissance et est destructrice. Dans tous ces cas, la structure multi-niveaux du qubit s'avere cruciale pour la mesure. En suggerant des facons d'ameliorer la mesure de qubits supraconducteurs, et en decrivant quantitativement la physique d'un systeme a plusieurs niveaux couple a un resonateur non lineaire excite, les resultats presentes dans cette these sont pertinents autant pour l'utilisation de l'architecture d'electrodynamique quantique en circuit pour l'informatique quantique que pour l'optique quantique. Mots-cles: electrodynamique quantique en circuit, informatique quantique, mesure, qubit supraconducteur, transmon, non-linearite Kerr

Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.

PubMed

Tolosa-Vilella, Carles; Morera-Morales, Maria Lluisa; Simeón-Aznar, Carmen Pilar; Marí-Alfonso, Begoña; Colunga-Arguelles, Dolores; Callejas Rubio, José Luis; Rubio-Rivas, Manuel; Freire-Dapena, Maika; Guillén-Del Castillo, Alfredo; Iniesta-Arandia, Nerea; Castillo-Palma, Maria Jesús; Egurbide-Arberas, Marivi; Trapiellla-Martínez, Luis; Vargas-Hitos, José A; Todolí-Parra, José Antonio; Rodriguez-Carballeira, Mónica; Marin-Ballvé, Adela; Pla-Salas, Xavier; Rios-Blanco, Juan José; Fonollosa-Pla, Vicent

2016-10-01

Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc. Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE). Demographics, organ involvement, autoimmunity features, nailfold capillary pattern, survival time, and causes of death were analyzed to identify DU related characteristics and survival of the entire series and according to the following cutaneous subsets-diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc), and SSc sine scleroderma (ssSSc). Out of 1326, 552 patients enrolled in the RESCLE registry had prior or current DU, 88% were women, the mean age was 50 ± 16 years, and the mean disease duration from first SSc symptom was 7.6 ± 9.6 years. Many significant differences were observed in the univariate analysis between patients with and without prior/current DU. Multivariate analysis identified that history of prior/current DU in patients with SSc was independently associated to younger age at SSc diagnosis, diffuse cutaneous SSc, peripheral vascular manifestations such Raynaud's phenomenon, telangiectasia, and acro-osteolysis but no other vascular features such as pulmonary arterial hypertension or scleroderma renal crisis. DU was also associated to calcinosis cutis, interstitial lung disease, as well as worse survival. Multivariate analysis performed in the cutaneous subsets showed that prior/current DU were independently associated: (1) in dcSSc, to younger age at SSc diagnosis, presence of telangiectasia and calcinosis and rarely a non-SSc pattern on nailfold capillaroscopy; (2) in lcSSc, to younger age at SSc diagnosis, presence of Raynaud's phenomenon as well as calcinosis cutis, interstitial lung disease, and higher incidence of death from all causes; and (3) in ssSSc, to younger age at first SSc symptom and greater incidence of death from all causes. Digital ulcers develop in patients with SSc younger at diagnosis, mainly in patients with dcSSc and lcSSc, and they are associated to other peripheral vascular manifestations such as Raynaud's phenomenon, telangiectasia, and acro-osteolysis but also to calcinosis, and interstitial lung disease. History of DU in SSc leads to worse survival, also noticeable for lcSSc and ssSSc subsets but not for dcSSc patients. Copyright © 2016 Elsevier Inc. All rights reserved.

Depleted uranium dust from fired munitions: physical, chemical and biological properties.

PubMed

Mitchel, R E J; Sunder, S

2004-07-01

This paper reports physical, chemical and biological analyses of samples of dust resulting from munitions containing depleted uranium (DU) that had been live-fired and had impacted an armored target. Mass spectroscopic analysis indicated that the average atom% of U was 0.198 +/- 0.10, consistent with depleted uranium. Other major elements present were iron, aluminum, and silicon. About 47% of the total mass was particles with diameters <300 microm, of which about 14% was <10 microm. X-ray diffraction analysis indicated that the uranium was present in the sample as uranium oxides-mainly U3O7 (47%), U3O8 (44%) and UO2 (9%). Depleted uranium dust, instilled into the lungs or implanted into the muscle of rats, contained a rapidly soluble uranium component and a more slowly soluble uranium component. The fraction that underwent dissolution in 7 d declined exponentially with increasing initial burden. At the lower lung burdens tested (<15 microg DU dust/lung) about 14% of the uranium appeared in urine within 7 d. At the higher lung burdens tested (~80-200 microg DU dust/lung) about 5% of the DU appeared in urine within 7 d. In both cases about 50% of that total appeared in urine within the first day. DU implanted in muscle similarly showed that about half of the total excreted within 7 d appeared in the first day. At the lower muscle burdens tested (<15 microg DU dust/injection site) about 9% was solubilized within 7 d. At muscle burdens >35 microg DU dust/injection site about 2% appeared in urine within 7 d. Natural uranium (NU) ore dust was instilled into rat lungs for comparison. The fraction dissolving in lung showed a pattern of exponential decline with increasing initial burden similar to DU. However, the decline was less steep, with about 14% appearing in urine for lung burdens up to about 200 microg NU dust/lung and 5% at lung burdens >1,100 microg NU dust/lung. NU also showed both a fast and a more slowly dissolving component. At the higher lung burdens of both DU and NU that showed lowered urine excretion rates, histological evidence of kidney damage was seen. Kidney damage was not seen with the muscle burdens tested. DU dust produced kidney damage at lower lung burdens and lower urine uranium levels than NU dust, suggesting that other toxic metals in DU dust may contribute to the damage.

Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds: Human health and ecological risk assessments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ebinger, M.H.; Beckman, R.J.; Myers, O.B.

1996-09-01

The purpose of this study was to evaluate the immediate and long-term consequences of depleted uranium (DU) in the environment at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) for the Test and Evaluation Command (TECOM) of the US Army. Specifically, we examined the potential for adverse radiological and toxicological effects to humans and ecosystems caused by exposure to DU at both installations. We developed contaminant transport models of aquatic and terrestrial ecosystems at APG and terrestrial ecosystems at YPG to assess potential adverse effects from DU exposure. Sensitivity and uncertainty analyses of the initial models showed the portionsmore » of the models that most influenced predicted DU concentrations, and the results of the sensitivity analyses were fundamental tools in designing field sampling campaigns at both installations. Results of uranium (U) isotope analyses of field samples provided data to evaluate the source of U in the environment and the toxicological and radiological doses to different ecosystem components and to humans. Probabilistic doses were estimated from the field data, and DU was identified in several components of the food chain at APG and YPG. Dose estimates from APG data indicated that U or DU uptake was insufficient to cause adverse toxicological or radiological effects. Dose estimates from YPG data indicated that U or DU uptake is insufficient to cause radiological effects in ecosystem components or in humans, but toxicological effects in small mammals (e.g., kangaroo rats and pocket mice) may occur from U or DU ingestion. The results of this study were used to modify environmental radiation monitoring plans at APG and YPG to ensure collection of adequate data for ongoing ecological and human health risk assessments.« less

Depleted Uranium Toxicity, Accumulation, and Uptake in Cynodon dactylon (Bermuda) and Aristida purpurea (Purple Threeawn).

PubMed

Butler, Afrachanna D; Wynter, Michelle; Medina, Victor F; Bednar, Anthony J

2016-06-01

Yuma Proving Grounds (YPG) in western Arizona is a testing range where Depleted uranium (DU) penetrators have been historically fired. A portion of the fired DU penetrators are being managed under controlled conditions by leaving them in place. The widespread use of DU in armor-penetrating weapons has raised environmental and human health concerns. The present study is focused on the onsite management approach and on the potential interactions with plants local to YPG. A 30 day study was conducted to assess the toxicity of DU corrosion products (e.g., schoepite and meta-schoepite) in two grass species that are native to YPG, Bermuda (Cynodon dactylon) and Purple Threeawn (Aristida purpurea). In addition, the ability for plants to uptake DU was studied. The results of this study show a much lower threshold for biomass toxicity and higher plant concentrations, particularly in the roots than shoots, compared to previous studies.

A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

PubMed

Jacob, A N; Kalapurakal, J; Davidson, W R; Kandpal, G; Dunson, N; Prashar, Y; Kandpal, R P

1999-01-01

We have used a modified differential display PCR protocol for isolating 3' restriction fragments of cDNAs specifically expressed or overexpressed in metastatic prostate carcinoma cell line DU145. Several cDNA fragments were identified that matched to milk fat globule protein, UFO/Axl, a receptor tyrosine kinase, human homologue of a Xenopus maternal transcript, laminin and laminin receptor, human carcinoma-associated antigen, and some expressed sequence tags. The transcript for milk fat globule protein, a marker protein shown to be overexpressed in breast tumors, was elevated in DU145 cells. The expression of UFO/Axl, a receptor tyrosine kinase, was considerably higher in DU145 cells as compared to normal prostate cells and prostatic carcinoma cell line PC-3. The overexpression of UFO oncogene in DU145 cells is discussed in the context of prostate cancer metastasis.

A new species of Neoperla (Plecoptera: Perlidae) from Zhejiang Province of China.

PubMed

Chen, Zhi-Teng

2016-03-24

The stonefly genus Neoperla Needham (1905) is primarily distributed in eastern North America, Tropical and Temperate Asia and central Africa, with at least 297 species known (Illies 1966, Zwick 1973, Stark & Gaufin 1976, DeWalt et al. 2016). Contributions to Chinese species of Neoperla were made by Chu (1929), Wu & Claassen (1934), Wu (1935, 1938, 1948, 1962, 1973), Yang & Yang (1992, 1995, 1998), Du (1999, 2000a, 2000b), Du et al. (1999, 2001), Du & Sivec (2004, 2005), Du & Wang (2005, 2007), Sivec & Zwick (1987), Li & Wang (2011), Li et al. (2011a, 2011b, 2012a, 2012b, 2013a, 2013b, 2014a, 2014b), Qin et al. (2013), Wang et al. (2013a, 2013b), Li & Zhang (2014), Kong et al. (2014), Wang et al. (2014), Chen & Du (2015). Herein, a new species of this genus is described from Taizhou, Zhejiang Province, of eastern coastal China.

Middle and late quaternary oceanography and climatology of the Zaire-Congo fan and the adjacent Eastern Angola basin

NASA Astrophysics Data System (ADS)

Jansen, J. H. F.; Van Weering, T. C. E.; Gieles, R.; Van Iperen, J.

La stratigraphie quaternaire du delta profond du Zaïre est établie sur la base des variations verticales des teneurs en carbonate, de l'analyse micropalaéontologique et des datations 14C et 230Th de 33 carottes. La vitesse des accumulations carbonatées et non carbonatées considérée en même temps que la conservation des carbonates nous conduit à distinguer les trois principaux facteurs à l'origine des concentrations en carbonate: production, dissolution et dilution par les particules non carbonatées. Les plus fortes productions carbonatées interviennent pendant les optima climatiques des interglaciaires tandis que les plus petites teneurs en carbonates sont probablement aussi liées à une augmentation de l'accumulation calcaire. Les fluctuations sont amplifiées par les effects de la dissolution qui est intense pendant les glaciaires et par les changements du rythme de la sédimentation terrigène. Dans la partie centrale du delta profond, un lobe de forte production carbonatée est localisé en permanence, il n'est pas associé à une zone de forte production de phytoplancton. Ce lobe est la conséquence d'un fort développement du zooplancton qui, pendant l'Holocène et les périodes interglaciaires, se multiplie à partir de cette floraison côtière de phytoplancton. Pendant les glaciaires, l'intensification de la circulation océanique déplace la zone des courants ascendants vers la latitude du delta du Zaïre. Dans deux carottes voisines de la bordure externe du plateau, une forte production en carbonates est observée entre 27 000 et 15 400 ans BP, elle est liée aux courants ascendants provoqués par l'intensification du courant de Benguela, et à une diminution de la sédimentation non carbonatée de de l'enfouissement du carbone organique à ˜ 14 500 ans BP. Une forte accumulation carbonatée se prolonge jusqu'à ˜12 500 ans BP, ce qui résulte un pic de conservation carbonatée à 14 000 ans BP qui n'est pas lié à un phénomène océanique. Une bréve intensification du compensation des carbonates et de la lysocline interviennent à des profondeurs moins grandes (4400 m et 3800 m) pendant les périodes glaciaires que de nos jours (5600 m et 4800 m). Les deux profondeurs des phases interglaciaires sont plus proches des profondeurs des phases glaciaires que de l'Holocène en fonction des dissolutions post-sédimentaires qui sont intervenues pendant les épisodes glaciaires consécutifs. L'hydrographie du Bassin de l'Angola n'apporte pas de preuves quant à des fluctuations des eaux profondes antarctiques qui auraient provoqué des cycles de dissolution des carbonates du Quaternaire de ce Bassin.

Graphs as a Managerial Tool: A Case Study of Du Pont's Use of Graphs in the Early Twentieth Century.

ERIC Educational Resources Information Center

Yates, JoAnne

1985-01-01

Sketches the development of business graphs in America. Examines their early use at Du Pont and the origin of the chart room around 1920, an important factor in the executive control systems at Du Pont. Draws lessons from this case study for managers and teachers of business communication. (PD)

40 CFR 52.1570 - Identification of plan.

Code of Federal Regulations, 2010 CFR

2010-07-01

... County 2.0 E. I. du Pont de Nemours & Co Deepwater, Salem County 1.5 Heinz-USA Salem City, Salem County 2... County 2.0 Atlantic City Electric Deepwater Station Penns Grove, Salem County 1.5 E. I. du Pont de... County 2.0 E. I. du Pont de Nemours & Co Deepwater, Salem County 1.5 Heinz-U.S.A Salem City, Salem County...

Speaking Truth to Power: Du Bois as Educator and Community Activist

ERIC Educational Resources Information Center

Grant, Carl A.; Grant, Paul D.

2017-01-01

This article uses W. E. B. Du Bois's work as an education and community activist to discuss race, oppression, and speaking-back to power in this time of racialized policies enacted by the Trump administration. This article centers a comparative discussion of the racialization of democracy by presidents Wilson and Trump to show the ways Du Bois was…

Race towards Freedom: W.E.B. Du Bois and the Tradition of Fugitive Black Study

ERIC Educational Resources Information Center

Tinson, Christopher M.

2017-01-01

This essay centers the defense of black educational possibility in the work of historian, pioneering sociologist, and scholar, W.E.B. Du Bois (1868-1963) as a conduit igniting what critical social theorists Stefano Harney and Fred Moten (2013) call Fugitive Black Study. The critical appreciation of Du Bois forces us to consider the weight of…

College of DuPage Planning Process: College of DuPage Planning, the Foundation for Decision Making.

ERIC Educational Resources Information Center

College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

At College of DuPage (CD), in Glen Ellyn, Illinois, institutional planning is a multi-level, on-going process involving continuous college-wide input. The nine schematic levels in the CD planning process are interconnected and progress from global and broad-based issues, answering such questions as why the college exists, to concrete levels…

Canadian Forces Training and Mental Preparation for Adversity: Empirical Review of Stoltz ’Adversity Quotient (AQ) Training for Optimal Response to Adversity’, A Review of the AQ Literature and Supporting Studies

DTIC Science & Technology

2002-07-01

canadiennes. Enfin, nous faisons des recommandations aux FC sur la mise en ceuvre duS processus de d6veloppement du QA comme mesure proactive. Un examen...critique des ouvrages lies au QA et A d’autres sujets connexes a montr6 que le concept du QA est fond6 sur un certain nombre de thdories sens~es sur la...rdsilience. Cependant, m~me si le cadre th~orique et le programme de d6veloppement du QA pourraicnt 8tre valides dans un contexte industriel

Science Town 2.0: An integrating Concept for S&T Support for Multi-Agency Crisis and Disaster Management

DTIC Science & Technology

2012-12-01

la Reine (en droit du Canada), telle que représentée par le ministre de la Défense nationale, 2012 DRDC CSS TM 2012-029 i...importantes forces d’application de la loi et de sécurité nationale de l’histoire du Canada. L’empreinte de la sécurité du théâtre d’opérations des Jeux...sécurité et de défense par la mise en place d’une « ville scientifique » mobile. La réussite du déploiement des

Structures spatiales localisées dans un oscillateur paramétrique optique (OPO)

NASA Astrophysics Data System (ADS)

Coulibaly, S.; Durniak, C.; Taki, M.

2004-11-01

La prise en compte du caractère non uniforme du pompage optique dans l'étude linéaire et faiblement non linéaire d'un OPO dégénéré (DOPO) a permis de mettre en évidence la discrétisation du seuil et l'existence de structures spatiales localisées de type Hermite-Gauss. L'évolution spatio-temporelle du signal en sortie est quant à elle gouvernée par l'équation de Ginzburg-Landau réelle dont les coefficients dépendent des variables d'espace.

Radiation and Electromagnetic Induction Data Fusion for Detection of Buried Radioactive Metal Waste - 12282

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, Zhiling; Wei, Wei; Turlapaty, Anish

2012-07-01

At the United States Army's test sites, fired penetrators made of Depleted Uranium (DU) have been buried under ground and become hazardous waste. Previously, we developed techniques for detecting buried radioactive targets. We also developed approaches for locating buried paramagnetic metal objects by utilizing the electromagnetic induction (EMI) sensor data. In this paper, we apply data fusion techniques to combine results from both the radiation detection and the EMI detection, so that we can further distinguish among DU penetrators, DU oxide, and non- DU metal debris. We develop a two-step fusion approach for the task, and test it with surveymore » data collected on simulation targets. In this work, we explored radiation and EMI data fusion for detecting DU, oxides, and non-DU metals. We developed a two-step fusion approach based on majority voting and a set of decision rules. With this approach, we fuse results from radiation detection based on the RX algorithm and EMI detection based on a 3-step analysis. Our fusion approach has been tested successfully with data collected on simulation targets. In the future, we will need to further verify the effectiveness of this fusion approach with field data. (authors)« less

Overview of the Capstone Depleted Uranium Study of Aerosols from Impact with Armored Vehicles: Test Setup and Aerosol Generation, Characterization, and Application in Assessing Dose and Risk

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parkhurst, MaryAnn; Guilmette, Raymond A.

2009-03-01

The Capstone Depleted Uranium (DU) Aerosol Characterization and Risk Assessment Study was conducted to generate data about DU aerosols generated during the perforation of armored combat vehicles with large-caliber DU penetrators, and to apply the data in assessments of human health risks to personnel exposed to these aerosols, primarily through inhalation, during the 1991 Gulf War or in future military operations. The Capstone study consisted of two components: 1) generating, sampling and characterizing DU aerosols by firing at and perforating combat vehicles and 2) applying the source-term quantities and characteristics of the aerosols to the evaluation of doses and risks.more » This paper reviews the background of the study including the bases for the study, previous reviews of DU particles and health assessments from DU used by the U.S. military, the objectives of the study components, the participants and oversight teams, and the types of exposures it was intended to evaluate. It then discusses exposure scenarios used in the dose and risk assessment and provides an overview of how the field tests and dose and risk assessments were conducted.« less

Role of SMAD4 in the mechanism of valproic acid's inhibitory effect on prostate cancer cell invasiveness.

PubMed

Jiang, Wei; Zheng, Yi; Huang, Zhongxian; Wang, Muwen; Zhang, Yinan; Wang, Zheng; Jin, Xunbo; Xia, Qinghua

2014-05-01

To investigate the influence of the histone deacetylase inhibitor valproic acid (VPA) on SMAD4 expression and invasive ability of prostate cancer cell lines. DU145 and PC3 cell lines were treated with 0, 2, and 5 mMol/l of VPA; invasion of DU145 and PC3 cells were then examined by transwell assay. Immunohistochemistry and Western blot were used to examine SMAD4 protein expression in DU145 and PC3 cells. Compared with controls, VPA significantly suppressed invasiveness in both PC3 and DU145 cells in a dose-dependent way (P < 0.05). VPA also inhibited AKT protein (which was regarded as an effective indicator here), and meanwhile, SMAD4 expression was down-regulated after VPA treatment in a dose-dependent manner in both DU145 (P < 0.05) and PC3 (P < 0.01) cells. Valproic acid could suppress invasiveness of prostate cancer cell lines PC3 and Du145, possibly through multiple pathways other than the SAMD4 pathway. This implies that VPA treatment combined with other SMAD4 enhancers could form a basis for a novel prostate cancer treatment.

Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro.

PubMed

Liu, Xiao-Jia; Li, Yun-Qian; Chen, Qiu-Yue; Xiao, Sheng-Jun; Zeng, Si-En

2014-01-01

Prostate cancer is one of the most prevalent malignant cancers in men. The isoflavone formononetin is a main active component of red clover plants. In the present study, we assessed the effect of formononetin on human prostate cancer DU-145 cells in vitro, and elucidated possible mechanisms. DU-145 cells were treated with different concentrations of formononetin and cell proliferation was assessed by MTT assay, cell apoptosis by Hoechst 33258 and flow cytometry, and protein levels of RASD1, Bcl-2 and Bax by Western blotting. The results showed that formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax. The level of RASD1 reached its maximum at 48 h post-treatment, and rapidly decreased thereafter. Together, we present evidence that formononetin triggered cell apoptosis through the mitochondrial apoptotic pathway by up-regulating RASD1.

Ensemble des troubles causés par l'alcoolisation fœtale : lignes directrices canadiennes concernant le diagnostic

PubMed Central

Chudley, Albert E.; Conry, Julianne; Cook, Jocelynn L.; Loock, Christine; Rosales, Ted; LeBlanc, Nicole

2005-01-01

Résumé LE DIAGNOSTIC DE L'ENSEMBLE DES TROUBLES CAUSÉS PAR L'ALCOOLISATION FÉTALE (ETCAF) est complexe et l'élaboration de lignes directrices concernant le diagnostic est justifiée. Un sous-comité du Comité consultatif national de l'Agence de santé publique du Canada sur l'Ensemble des troubles causés par l'alcoolisation fœtale a examiné, analysé et intégré les méthodes de diagnostic actuelles afin de parvenir à une méthode de diagnostic normalisée faisant le consensus au Canada. L'objet du présent document est d'examiner et de clarifier l'utilisation des systèmes de diagnostic actuels et de formuler des recommandations quant à leur application pour le diagnostic des déficiences liées à l'ETCAF chez des individus de tous les âges. Les lignes directrices sont fondées sur un vaste consensus de praticiens et d'autres intervenants spécialisés dans le domaine. Ces lignes directrices ont été organisées en sept catégories, soit le dépistage et l'orientation vers les spécialistes, l'examen physique et le diagnostic différentiel, l'évaluation du comportement neurologique, le traitement et le suivi, les antécédents de consommation d'alcool de la mère pendant la grossesse, les critères du diagnostic pour le syndrome d'alcoolisation fœtale (SAF), SAF partiel et troubles neurologiques du développement liés à l'alcool, l'harmonisation de l'Institute of Medicine (IOM) et des approches du Code diagnostique à 4 chiffres. Le diagnostic exige une évaluation complète des antécédents, ainsi qu'un examen physique et du comportement neurologique, tout en recourant à une approche multidisciplinaire. Les présentes lignes directrices pour le diagnostic du syndrome d'alcoolisation fœtale et des déficiences qui y sont associées sont les premières à avoir été élaborées au Canada et elles sont fondées sur la consultation d'un grand éventail de spécialistes du diagnostic.

Étude des déterminants individuels de l’adoption du dossier de santé électronique du Québec

PubMed Central

Mezni, H; M-P, Gagnon; Duplantie, J

2016-01-01

Résumé Objectif Selon des études précédentes, les dossiers de santé électroniques peuvent améliorer l’efficacité, la sécurité et la qualité de la prise en charge médicale. Cependant, les prestataires de soins restent réticents quant à son utilisation, ce qui limite son impact sur le système de santé. La présente étude avait pour objectif d’évaluer les perceptions des médecins face au dossier de santé du Québec. Méthodes À partir d’une revue de la littérature sur les facteurs influençant l’adoption des nouvelles technologies de l’information et des communications (NTIC) en général et de la cybersanté en particulier, nous avons élaboré un questionnaire semi-structuré. Au total, 12 médecins utilisateurs potentiels du dossier de santé du Québec (DSQ) ont complété et retourné le questionnaire. Par la suite, nous avons opéré une analyse thématique de contenu, suivie par une théorisation des concepts obtenus. Résultats L’intention d’adopter le DSQ est influencée positivement par l’utilité perçue, la facilité d’utilisation perçue, la démonstrabilité des résultats, la compatibilité du système avec la pratique et l’autoefficacité informatique perçue par les médecins. Inversement, la résistance au changement influence négativement l’adoption du DSQ par les médecins. Conclusion L’identification des déterminants de l’adoption du dossier de santé du Québec est cruciale pour les responsables du secteur de la santé au Québec. Il sera ainsi possible de saisir les attentes des utilisateurs potentiels et d’ajuster les stratégies d’implantation en vue de favoriser une meilleure intégration de cette technologie dans les pratiques médicales. PMID:27867453

Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

NASA Astrophysics Data System (ADS)

Bourdi, Taoufik

Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents types de beton et a differentes teneurs en eau. Dans une derniere partie, nous avons presente l'utilisation du modele de Jonscher pour l'estimation de l'epaisseur d'une dalle de beton par la technique GPR dans le domaine frequentiel. Mots-cles : CND, beton, georadar , permittivite, Jonscher

Prediction du profil de durete de l'acier AISI 4340 traite thermiquement au laser

NASA Astrophysics Data System (ADS)

Maamri, Ilyes

Les traitements thermiques de surfaces sont des procedes qui visent a conferer au coeur et a la surface des pieces mecaniques des proprietes differentes. Ils permettent d'ameliorer la resistance a l'usure et a la fatigue en durcissant les zones critiques superficielles par des apports thermiques courts et localises. Parmi les procedes qui se distinguent par leur capacite en terme de puissance surfacique, le traitement thermique de surface au laser offre des cycles thermiques rapides, localises et precis tout en limitant les risques de deformations indesirables. Les proprietes mecaniques de la zone durcie obtenue par ce procede dependent des proprietes physicochimiques du materiau a traiter et de plusieurs parametres du procede. Pour etre en mesure d'exploiter adequatement les ressources qu'offre ce procede, il est necessaire de developper des strategies permettant de controler et regler les parametres de maniere a produire avec precision les caracteristiques desirees pour la surface durcie sans recourir au classique long et couteux processus essai-erreur. L'objectif du projet consiste donc a developper des modeles pour predire le profil de durete dans le cas de traitement thermique de pieces en acier AISI 4340. Pour comprendre le comportement du procede et evaluer les effets des differents parametres sur la qualite du traitement, une etude de sensibilite a ete menee en se basant sur une planification experimentale structuree combinee a des techniques d'analyse statistiques eprouvees. Les resultats de cette etude ont permis l'identification des variables les plus pertinentes a exploiter pour la modelisation. Suite a cette analyse et dans le but d'elaborer un premier modele, deux techniques de modelisation ont ete considerees, soient la regression multiple et les reseaux de neurones. Les deux techniques ont conduit a des modeles de qualite acceptable avec une precision d'environ 90%. Pour ameliorer les performances des modeles a base de reseaux de neurones, deux nouvelles approches basees sur la caracterisation geometrique du profil de durete ont ete considerees. Contrairement aux premiers modeles predisant le profil de durete en fonction des parametres du procede, les nouveaux modeles combinent les memes parametres avec les attributs geometriques du profil de durete pour refleter la qualite du traitement. Les modeles obtenus montrent que cette strategie conduit a des resultats tres prometteurs.

Rescue of a duck circovirus from an infectious DNA clone in ducklings.

PubMed

Li, Pengfei; Zhang, Zhilong; Jia, Renyong; Mao, Sai; Wang, Mingshu; Jia, Ruiling; Liu, Mafeng; Zhu, Dekang; Chen, Shun; Sun, Kunfeng; Yin, Zhongqiong; Chen, Xiaoyue; Cheng, Anchun

2015-05-30

Duck circovirus may predispose the host to immunosuppression and may serve as an immunological trigger for further complicated disease progression. Due to the lack of a cell culture system for propagating DuCV, little is known regarding the molecular biology and pathogenesis of DuCV. The aim of this study was to describe the construction and initial in vivo characterization of full-length DNA clones of DuCV (pIC-Mu2DuCV) and its infectivity under in vivo conditions. The constructed pIC-Mu2DuCV contained two copies of the whole DuCV genome and an introduced Xho I restriction enzyme site. Eighty-one 10-day-old conventional ducklings that were free of DuCV were randomly divided equally into three groups (1, 2 and 3). The ducklings in groups 1, 2 and 3 were inoculated intramuscularly with pIC-Mu2DuCV, wild-type virus GH01 and PBS, respectively. Subsequently, all of the ducklings were examined clinically, which were each given a physical condition score, and their rectal temperatures were taken daily during the experimental period. DuCV genomes in serum samples and in various tissues from all of the ducklings at 0, 1, 3, 5, 7, 10, 15, 21 and 28 DPC were detected by PCR and real-time quantitative PCR, respectively. The average daily weight gain (ADWG) of group 3 was significantly higher than those of groups 1 and 2, and the temperature of all ducklings was stable between 41.7 °C and 42.2 °C. The clinical values (physical condition scores) of groups 1, 2 and 3 were 12.5, 15.6 and 0, respectively. In addition, viremia occurred at 15 and 10 days post-challenge (DPC) in groups 1 and 2, and antibodies could be detected in these ducklings at 21 and 15 DPC. Proliferation ability analysis showed that the viral titers of group 1 were lower than those of their parental viruses in group 2. This study shows that the rescued viruses are not significantly different but exhibit lower pathogenicity and proliferation ability compared with the parental virus. The results will facilitate future studies on DuCV pathogenesis and biology.

SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells.

PubMed

Rybak, Adrian P; Tang, Damu

2013-12-01

SOX2 is an essential transcription factor for stem cells and plays a role in tumorigenesis, however its role in prostate cancer stem cells (PCSCs) remains unclear. We report here a significant upregulation of SOX2 at both mRNA and protein levels in DU145 PCSCs propagated as suspension spheres in vitro. The expression of SOX2 in DU145 PCSCs is positively regulated by epidermal growth factor receptor (EGFR) signaling. Activation of EGFR signaling, following the addition of epidermal growth factor (EGF) or ectopic expression of a constitutively-active EGFR mutant (EGFRvIII), increased SOX2 expression and the self-renewal of DU145 PCSCs. Conversely, a small molecule EGFR inhibitor (AG1478) blocked EGFR activation, reduced SOX2 expression and inhibited PCSC self-renewal activity, implicating SOX2 in mediating EGFR-dependent self-renewal of PCSCs. In line with this notion, ectopic SOX2 expression enhanced EGF-induced self-renewal of DU145 PCSCs, while SOX2 knockdown reduced PCSC self-renewal with EGF treatment no longer capable of enhancing their propagation. Furthermore, SOX2 knockdown reduced the capacity of DU145 PCSCs to grow under anchorage-independent conditions. Finally, DU145 PCSCs generated xenograft tumors more aggressively with elevated levels of SOX2 expression compared to xenograft tumors derived from non-PCSCs. Collectively, we provide evidence that SOX2 plays a critical role in EGFR-mediated self-renewal of DU145 PCSCs. © 2013.

The use of depleted uranium ammunition under contemporary international law: is there a need for a treaty-based ban on DU weapons?

PubMed

Borrmann, Robin

2010-01-01

This article examines whether the use of Depleted Uranium (DU) munitions can be considered illegal under current public international law. The analysis covers the law of arms control and focuses in particular on international humanitarian law. The article argues that DU ammunition cannot be addressed adequately under existing treaty based weapon bans, such as the Chemical Weapons Convention, due to the fact that DU does not meet the criteria required to trigger the applicability of those treaties. Furthermore, it is argued that continuing uncertainties regarding the effects of DU munitions impedes a reliable review of the legality of their use under various principles of international law, including the prohibition on employing indiscriminate weapons; the prohibition on weapons that are intended, or may be expected, to cause widespread, long-term and severe damage to the natural environment; and the prohibition on causing unnecessary suffering or superfluous injury. All of these principles require complete knowledge of the effects of the weapon in question. Nevertheless, the author argues that the same uncertainty places restrictions on the use of DU under the precautionary principle. The paper concludes with an examination of whether or not there is a need for--and if so whether there is a possibility of achieving--a Convention that comprehensively outlaws the use, transfer and stockpiling of DU weapons, as proposed by some non-governmental organisations (NGOs).

Stromal interaction molecule 1 (STIM1) silencing inhibits tumor growth and promotes cell cycle arrest and apoptosis in hypopharyngeal carcinoma.

PubMed

Sun, Yuanhao; Cui, Xiaobo; Wang, Jun; Wu, Shuai; Bai, Yunfei; Wang, Yaping; Wang, Boqian; Fang, Jugao

2015-05-01

As an important pathway maintaining the balance of intracellular calcium (Ca(2+)), store-operated Ca(2+) entry (SOCE) is critical for cellular functions. Stromal interaction molecule 1 (STIM1), a key component of SOCE, plays a dual role as an endoplasmic reticulum Ca(2+) receptor and an SOCE exciter. Aberrant expression of STIM1 could be discovered in several human cancer cells. However, the role of STIM1 in regulating human hypopharyngeal carcinoma still remains unclear. Real-time polymerase chain reaction (PCR) was used to detect expression of STIM1 in human hypopharyngeal carcinoma cell line FaDu. STIM1 on FaDu cells was knocked down by lentiviral transduction method. The biological impacts after knocking down of STIM1 on FaDu cells were investigated in vitro and in vivo. The result of real-time PCR showed that STIM1 was expressed in FaDu cells. Lentiviral transduction efficiently downregulated the expression of STIM1 in FaDu cells at both mRNA and protein levels. Significant downregulation of STIM1 on FaDu cells inhibited cell proliferation, induced cell cycle arrest in G0/G1 phase, promoted cell apoptosis, and restrained cell growth rate. The antigrowth effect of STIM1 silencing was also discovered in FaDu hypopharyngeal tumor model. Our findings indicate that STIM1 is likely to become a new therapeutic target for hypopharyngeal carcinoma treatment.

Approches pour la reduction de l'impact de defaut dans le transport d'energie du parc eolien offshore via VSC-HVDC =

NASA Astrophysics Data System (ADS)

Benadja, Mounir

Dans ce travail est presente un systeme de generation d'energie d'un parc eolien offshore et un systeme de transport utilisant les stations VSC-HVDC connectees au reseau principal AC onshore. Trois configurations ont ete etudiees, modelisees et validees par simulation. Dans chacune des configurations, des contributions ameliorant les cotes techniques et economiques sont decrites ci-dessous : La premiere contribution concerne un nouvel algorithme MPPT (Maximum Power Point Tracking) utilise pour l'extraction de la puissance maximale disponible dans les eoliennes des parcs offshores. Cette technique d'extraction du MPPT ameliore le rendement energetique de la chaine de conversion des energies renouvelables notamment l'energie eolienne a petite et a grande echelles (parc eolien offshore) qui constitue un probleme pour les constructeurs qui se trouvent confrontes a developper des dispositifs MPPT simples, moins couteux, robustes, fiables et capable d'obtenir un rendement energetique maximal. La deuxieme contribution concerne la reduction de la taille, du cout et de l'impact des defauts electriques (AC et DC) dans le systeme construit pour transporter l'energie d'un parc eolien offshore (OWF) vers le reseau principal AC onshore via deux stations 3L-NPC VSCHVDC. La solution developpee utilise des observateurs non-lineaires bases sur le filtre de Kalman etendu (EKF). Ce filtre permet d'estimer la vitesse de rotation et la position du rotor de chacune des generatrices du parc eolien offshore et de la tension du bus DC de l'onduleur DC-AC offshore et des deux stations 3L-NPC-VSC-HVDC (offshore et onshore). De plus, ce developpement du filtre de Kalman etendu a permis de reduire l'impact des defauts AC et DC. Deux commandes ont ete utilisees, l'une (commande indirect dans le plan abc) avec EKF integre destinee pour controler le convertisseur DC-AC offshore et l'autre (commande d-q) avec EKF integre pour controler les convertisseurs des deux stations AC-DC et DC-AC tout en tenant compte des entrees de chacune des stations. L'integration des observateurs non-lineaires (EKF) dans le controle des convertisseurs permet de resoudre le probleme des incertitudes de mesure, des incertitudes dans la modelisation, en cas du dysfonctionnement ou de panne des capteurs de mesure ainsi que le probleme de l'impact des defauts (AC et DC) sur la qualite d'energie dans les systemes de transmission. Ces estimations contribuent a rendre le cout global du systeme moins cher et sa taille moins encombrante ainsi que la reduction de l'impact des defauts (AC et DC) sur le systeme. La troisieme contribution concerne la reduction de la taille, du cout et de l'impact des defauts electriques (AC et DC) dans le systeme construit pour transporter l'energie d'un parc eolien offshore (OWF) vers le reseau principal AC onshore via deux stations VSC-HVDC. La solution developpee utilise des observateurs non-lineaires bases sur le filtre de Kalman etendu (EKF). Ce filtre permet d'estimer la vitesse de rotation et la position du rotor de chacune des generatrices du parc eolien et de la tension du bus DC de l'onduleur DC-AC offshore. La contribution porte surtout sur le developpement des deux commandes des deux stations. La premiere, la commande non-lineaire modifiee pour controler le premier convertisseur de la station VSC-HVDC offshore assurant le transfert de la puissance generee par le parc eolien vers la station VSC-HVDC onshore. La deuxieme commande non-lineaire modifiee avec integration de la regulation de la tension du bus DC et de la commande a modele de reference adaptative (MRAC) pour la compensation des surintensites et surtensions durant les defauts AC et DC. On peut constater que lors d'un defaut AC au PCC (Point of Common Coupling) du cote reseau onshore, la profondeur de l'impact du defaut AC sur l'amplitude des courants du reseau principal AC onshore qui etait reduit a 60% par les travaux de recherche (Erlich, Feltes et Shewarega, 2014), comparativement a la nouvelle commande proposee MRAC qui reduit la profondeur de l'impact a 35%. Lors de l'apparition des defauts AC et DC, une reduction de l'impact des defauts sur l'amplitude des courants de reseau AC terrestre et du temps de reponse a ete observee et la stabilite du systeme a ete renforcee par l'utilisation de la commande adaptative basee sur le modele de reference MRAC. La quatrieme contribution concerne une nouvelle commande basee sur le mode de glissement (SM) appliquee pour la station VSC-HVDC qui relie le parc eolien offshore (OWF) au reseau principal AC. Ce parc est compose de dix eoliennes basees sur des generatrices synchrones a aimant permanent (VSWT/PMSGs) connectees en parallele et chacune est controlee par son propre convertisseur DC-DC. Une comparaison des performances entre la commande SM et de la commande non-lineaire avec des controleurs PI pour les deux conditions (presence et absence de defaut DC) a ete analysee et montre la superiorite de la commande par SM. Un prototype du systeme etudie a echelle reduite a ete realise et teste au laboratoire GREPCI en utilisant la carte dSPACE-DS1104 pour la validation experimentale. L'analyse et la simulation des systemes etudies sont developpees sous l'environnement Matlab/Simulink/Simpowersystem. Les resultats obtenus a partir des configurations developpees sont valides par simulation et par experimentation. Les performances sont tres satisfaisantes du point de vue reponse dynamique, reponse en regime permanent, stabilite du systeme et qualite de l'energie.

Federal Protection for Human Research Subjects: An Analysis of the Common Rule and Its Interactions with FDA Regulations and the HIPAA Privacy Rule

DTIC Science & Technology

2005-06-02

the interaction of the Privacy Rule and FDA regulations with the Common Rule. Appendix B CRS-12 20 Phocomelia Syndrome is a birth defect that may...linked to the birth defect phocomelia .20 ! Congress enacts the Drug Amendments of 1962 (P.L. 87-781), requiring researchers to obtain subjects...information about Phocomelia Syndrome, see [http://my.webmd.com/hw/health_guide_atoz/nord780.asp], visited Apr. 11, 2005. 178 Section 505(i) of the Food

Ocean Thermal Analysis and Related Naval Operational Considerations in the Ionian Sea - June 1980.

DTIC Science & Technology

1981-09-01

oceanography and XBT sampl- ing procedures are made. 4 RESUME L’analyse synoptique de la mer Ionienne en Juin 1980 r~v~le des structures thermiques...varides, et en particulier, un tourbillon chaud comparable en taille et position A celui trouv6 aui cours de MILOC-68. Les fonctions de corr~1ation...spatiale en temp~rature sont anisotropiques dans la partie sud, avec des 6chelles respectives de 30 et 40 A 80 km dans les directions Est/Quest et Nord/Sud

Personnel Attrition Rates in Historical Land Combat Operations: A Catalog of Attrition and Casualty Data Bases on Diskettes Usable with Personal Computers

DTIC Science & Technology

1993-09-01

la Universidad de Malaga, et al., 1991, pp 4985-5017. (2) Pearson, Frederic S., and Robert A. Baumann, "International Military Intervention in Sub...unobtainable in practice. Instead, we must use the data as we find it, warts and all. This is not a new observation. Beebe. Gilbert W., and De Bakey...original or US copies of the British "Nord de Guerre Zone," based on the Lambert Conformal Conical Projection, which the British call the Lambert Conical

78 FR 65715 - Notice of Lodging of Proposed Consent Decree Under the Clean Air Act

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-01

... of West Virginia v. E. I. du Pont de Nemours and Company, Civil Action No. 6:13-cv-27030. E. I. du Pont de Nemours and Company (``DuPont'') owns and operates a chemical manufacturing facility located in... amount of the civil penalty is based on the EPA Clean Air Act Stationary Source Civil Penalty Policy. The...

Test Area C-64 Range Environmental Assessment, Revision 1

DTIC Science & Technology

2010-10-01

DOI U.S. Department of the Interior DNL Day–Night Average Sound Level DU Depleted Uranium EBD Environmental Baseline Document EIAP Environmental...vulnerability, burning sensitivity, drop tests, bullet impact tests, sympathetic detonation tests, advanced warhead design tests, and depleted uranium (DU...land back to range use. Source: U.S. Air Force, 2009 DU = depleted uranium ; ERP = Environmental Restoration Program; LUC = land use control; RW

History of Cern

ScienceCinema

None

2017-12-09

Cérémonie à l'occasion de l'apparition du premier volume du livre sur l'histoire du Cern, avec plusieurs personnes présentes qui jouaient un rôle important dans cette organisation européenne couronnée de succès grâce à l'esprit des membres fondateurs qui est et restera essentiel

25th Birthday Cern- Amphi

ScienceCinema

None

2017-12-09

Cérémonie du 25ème anniversaire du Cern avec 2 orateurs: le Prof.Weisskopf parle de la signification et le rôle du Cern et le Prof.Casimir(?) fait un exposé sur les rélations entre la science pure et la science appliquée et la "big science" (science légère)

Survie au cancer du sein à Rabat (Maroc) 2005-2008

PubMed Central

Mechita, Nada Bennani; Tazi, Mohammed Adnane; Er-Raki, Abdelouahed; Mrabet, Mustapha; Saadi, Asma; Benjaafar, Noureddine; Razine, Rachid

2016-01-01

Introduction Le cancer du sein représente un problème de santé publique au Maroc. L’objectif de ce travail était d’estimer le taux de survie au cancer du sein chez les patientes habitant la ville de Rabat. Méthodes Etude pronostique réalisée chez les patientes diagnostiquées pour cancer du sein de 2005 à 2008, habitant la ville de Rabat et enregistrées au registre des cancers de Rabat. La date d’inclusion dans l’étude correspondait à la date de confirmation histologique du cancer. L’estimation de la survie a été réalisée par la méthode de Kaplan Meier, et la comparaison entre les différentes classes d’une variable a été réalisée par le test de log rank. L’étude des facteurs associés à la survie a été effectuée par le modèle de Cox. Résultats Durant la période d’étude 628 cas de cancer du sein ont été collectés. Le pourcentage de décès était de 19,9%. La survie globale à un an était de 97,1%, elle était de 89,2% à 3 ans et de 80,6 % à 5 ans. En analyse multivariée la survie au cancer du sein était statistiquement moins bonne chez les patientes âgées de plus de 70 ans (p<0,001), ayantune grande taille de tumeur (p<0,001), un stade avancé d’adénopathies (p=0,007), présentant des métastases (p<0,001) et non traitées par hormonothérapie (p=0,002). Conclusion Une grande taille de la tumeur et la présence de métastases sont des facteurs de mauvais pronostic du cancer du sein d’où la nécessité de renforcer les programmes de dépistage. PMID:28292106

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism

PubMed Central

Ayuso, Miriam; Fernández, Almudena; Núñez, Yolanda; Benítez, Rita; Isabel, Beatriz; Barragán, Carmen; Fernández, Ana Isabel; Rey, Ana Isabel; Medrano, Juan F.; Cánovas, Ángela; González-Bulnes, Antonio; López-Bote, Clemente; Ovilo, Cristina

2015-01-01

Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness. This experiment was conducted to investigate gene expression differences, transcriptional regulation and genetic polymorphisms that could be associated with the observed phenotypic differences between IB and IBxDU pigs. Nine IB and 10 IBxDU pigs were slaughtered at birth. Morphometric measures and blood samples were obtained and samples from Biceps femoris muscle were employed for compositional and transcriptome analysis by RNA-Seq technology. Phenotypic differences were evident at this early age, including greater body size and weight in IBxDU and greater Biceps femoris intramuscular fat and plasma cholesterol content in IB newborns. We detected 149 differentially expressed genes between IB and IBxDU neonates (p < 0.01 and Fold-Change > 1. 5). Several were related to adipose and muscle tissues development (DLK1, FGF21 or UBC). The functional interpretation of the transcriptomic differences revealed enrichment of functions and pathways related to lipid metabolism in IB and to cellular and muscle growth in IBxDU pigs. Protein catabolism, cholesterol biosynthesis and immune system were functions enriched in both genotypes. We identified transcription factors potentially affecting the observed gene expression differences. Some of them have known functions on adipogenesis (CEBPA, EGRs), lipid metabolism (PPARGC1B) and myogenesis (FOXOs, MEF2D, MYOD1), which suggest a key role in the meat quality differences existing between IB and IBxDU hams. We also identified several polymorphisms showing differential segregation between IB and IBxDU pigs. Among them, non-synonymous variants were detected in several transcription factors as PPARGC1B and TRIM63 genes, which could be associated to altered gene function. Taken together, these results provide information about candidate genes, metabolic pathways and genetic polymorphisms potentially involved in phenotypic differences between IB and IBxDU pigs associated to meat quality and production traits. PMID:26695515

Les accidents du travail dans le transport urbain en commun de la ville province de Kinshasa, République Démocratique du Congo: une étude transversale descriptive

PubMed Central

Wangata, Jemima; Elenge, Myriam; De Brouwer, Christophe

2014-01-01

Introduction Le transport en commun urbain constitue un secteur où les travailleurs sont très exposés aux accidents du travail. Cette étude visait une description épidémiologique des accidents du travail dans le secteur informel du transport en commun à Kinshasa en vue d'apporter les pistes d'amélioration de la sécurité des travailleurs dans cette activité. Méthodes Un questionnaire sur les accidents du travail, administré en Décembre 2012 a permis d'explorer les tendances significatives entre les accidents et leurs circonstances, leurs facteurs associés, leurs conséquences au sein d'une population des travailleurs (n = 472) du transport en commun à Kinshasa. Résultats Durant les 12 derniers précédant l’étude 76.5% des travailleurs ont connu au moins un accident du travail, 54,8% ont connu un arrêt d'au moins 1jour. Les accidents liés à la circulation routière étaient plus important suivis des chutes. Les facteurs ayant montré des différences significatives étaient le travail sous l'influence de l'alcool et le port des équipements de protection individuelle. Les plaies (46,3%) et les contusions (39,4%) étaient les lésions les plus courantes. Les membres supérieurs (51,3%) et inférieurs (30,7%) étaient les plus atteints. 76,6% des travailleurs ont assumé seuls leur prise en charge médicale. Conclusion L'incidence des accidents du travail dans ce secteur est très élevée. La mise en place d'une politique de prévention et gestion de différents facteurs associés ainsi qu'un système de déclaration d'accidents est nécessaire dans ce secteur. Les patrons ainsi que les politiques devraient veiller à une prise en charge médicale correcte pour des travailleurs accidentés. PMID:25667703

Contribution a l'etude et au developpement de nouvelles poudres de fonte

NASA Astrophysics Data System (ADS)

Boisvert, Mathieu

L'obtention de graphite libre dans des pieces fabriquees par metallurgie des poudres (M/P) est un defi auquel plusieurs chercheurs se sont attardes. En effet, la presence de graphite apres frittage ameliore l'usinabilite des pieces, permettant donc de reduire les couts de production, et peut aussi engendrer une amelioration des proprietes tribologiques. L'approche utilisee dans cette these pour tenter d'obtenir du graphite libre apres frittage est par l'utilisation de nouvelles poudres de fontes atomisees a l'eau. L'atomisation a l'eau etant un procede de production de poudres relativement peu couteux qui permet de grandes capacites de production, le transfert des decouvertes de ce doctorat vers des applications industrielles sera donc economiquement plus favorable. En plus de l'objectif d'obtenir du graphite libre apres frittage, un autre aspect important des travaux est le controle de la morphologie du graphite libre apres frittage. En effet, il est connu dans la litterature des fontes coulees/moulees que la morphologie du graphite influencera les proprietes des fontes, ce qui est aussi vrai pour les pieces de M/P. Les fontes ductiles, pour lesquelles le graphite est sous forme de nodules spheroidaux isoles les uns des autres, possedent des proprietes mecaniques superieures aux fontes grises pour lesquelles le graphite est sous forme lamellaire et continu dans la matrice. Les resultats presentes dans cette these montrent qu'il est possible, dans des melanges contenant des poudres de fontes, d'avoir un controle sur la morphologie du graphite et donc sur les proprietes des pieces. Le controle de la morphologie du graphite a principalement ete realise par le type de frittage et le phenomene de diffusion " uphill " du carbone cause par des gradients en silicium. En effet, pour les frittages en phase solide, tous les nodules de graphite sont presents a l'interieur des grains de poudre apres frittage. Pour les frittages en phase liquide, l'intensite de la diffusion " uphill " permet de conserver plus ou moins de graphite nodulaire a l'interieur des regions riches en silicium, alors que le reste du graphite precipite sous forme lamellaire/vermiculaire dans les regions interparticulaires. L'etude des poudres de fontes et la recherche des mecanismes regissant la morphologie du graphite dans les fontes coulees/moulees nous ont amenes a produire des poudres de fontes traitees au magnesium avant l'atomisation. Plusieurs resultats fondamentaux ont ete obtenus de la caracterisation des poudres traitees au magnesium et de leur comparaison avec des poudres de chimies similaires non traitees au magnesium. D'abord, il a ete possible d'observer des bifilms d'oxyde de silicium dans la structure du graphite primaire d'une poudre de fonte grise hypereutectique. Il s'agit des premieres images montrant la structure double de ces defauts, venant ainsi appuyer la theorie elaboree par le professeur John Campbell. Ensuite, il a ete montre que le traitement au magnesium forme une atmosphere protectrice gazeuse autogeneree qui empeche l'oxydation de la surface du bain liquide et donc, la formation et l'entrainement des bifilms. Le role du magnesium sur la morphologie du graphite est de diminuer le soufre en solution en formant des precipites de sulfure de magnesium et ainsi d'augmenter l'energie d'interface graphite-liquide. En reponse a cette grande energie d'interface graphite-liquide, le graphite cherche a minimiser son ratio surface/volume, ce qui favorise la formation de graphite spheroidal. De plus, deux types de germination ont ete observes dans la poudre de fonte hypereutectique traitee au magnesium. Le premier type est une germination heterogene sur un nombre limite de particules faites de magnesium, d'aluminium, de silicium et d'oxygene. Le deuxieme type est une germination homogene des nodules dans certaines regions du liquide plus riches en silicium. L'observation du centre reel tridimensionnel, en microscopie electronique en transmission en haute resolution, d'un des nodules ayant subi une germination homogene a permis de confirmer que le mode de croissance du graphite spheroidal se produit selon le modele de la croissance en feuille de chou. (Abstract shortened by ProQuest.).

The Flight of Flexible Aircraft in Turbulence. State-of-the-Art in the Description and Modelling of Atmospheric Turbulence. Addendum

DTIC Science & Technology

1988-06-01

diboucher sur des direc~ives qui seront d’une grande utilit6 bora de~ t’aaboration du Manuel AGARD de Ia turbulence, dont la partition eat privue fin...1988 debut 1989. Nous tenons ii f~liciter les auteurs de P’int&&~ et de Ia valeur des exposes qui ont 6t pr~sentis lors de Ia r~union, et de Ia part du...effectu~es sous l’gide de Ia FAA et du Panel AGARD de Ia M&canique du vol. in ____4 CONUMNS Pare A(FNDF~VI~L A1~JD ~F~WAIS A~A&NLS$URE~toD AND ~iGHT

Systemes Fermioniques a Basse Dimension D'espace: Supraconductivite, Effet Hall Quantique et Statistique Fractionnaire

NASA Astrophysics Data System (ADS)

Sakhi, Said

Cette these est constituee de trois sujets de recherche distincts. Les deux premiers articles traitent du phenomene de supraconductivite dans un modele bidimensionnel, dans le troisieme article on etudie l'action effective d'un systeme electronique soumis a l'effet d'un champ magnetique (systeme de Hall) et le dernier article examine la quantification d'un systeme de particules identiques en deux dimensions d'espace et la possibilite des anyons. Le modele qu'on analyse dans les deux premiers articles est un systeme fermionique dont les particules chargees et de masse nulle interagissent entre elles avcc un couplage attractif et fort. L'analyse de l'action effective decrivant la physique a basse energie nous permet d'examiner la structure de l'espace de phase. A temperature nulle, le parametre d'ordre du systeme prend une valeur moyenne non nulle. Consequemment, la symetrie continue U(1) du modele est spontanement brisee et il en resulte l'apparition d'un mode de Goldstone. En presence d'un champ electromagnetique externe, ce mode disparait et le champ de jauge acquiert une masse donc l'effet Meissner caracteristique d'un supraconducteur. Bien que le modele ne soit pas renormalisable dans le sens perturbatif, on montre qu'il l'est dans le cadre du developpement en 1/N ou N est le nombre d'especes fermioniques. En outre, on montre que l'inclusion des effets thermiques change radicalement le mecanisme de supraconductivite. En effet, on montre que la brisure spontanee de la symetrie U(1) n'est plus possible a temperature finie a cause de tres severes divergences infrarouges. Par contre, la dynamique des tourbillons (vortex) existant dans le plan devient essentielle. On montre que le phenomene de supraconductivite resulte du confinement de ces objets topologiques et que la temperature critique s'identifie a celle de Kosterlitz -Thouless. Ce mecanisme de supraconductivite presente l'avantage d'aboutir a un rapport gap a la temperature critique plus eleve que celui du modele de BCS et la non violation de la symetrie par renversement du temps et de l'espace contrairement au modele anyonique. Dans le troisieme article, on a developpe une methode systematique pour calculer les determinants fermioniques en presence d'un champ magnetique perpendiculaire au plan de confinement des particules. Aussi bien les effets thermiques que ceux dus aux impuretes sont pris en consideration dans cette methode. La technique est illustree dans le cas du systeme de Hall quantique. Finalement, dans le dernier article, on discute la quantification d'un systeme de particules identiques dans le plan. Apres avoir correctement defini l'espace de phase classique du systeme, l'analyse fait ressortir deux parametres fondamentaux denotes par theta et alpha. Le premier parametre theta est associe a l'intensite du flux magnetique localise au vertex du cone et definit la statistique des particules. Pour des valeurs arbitraires de theta on parle d'anyons. L'autre parametre alpha est associe a l'extension auto-adjointe de l'hamiltonien et ressort de l'unitarite de la theorie. On montre par un exemple explicite que alpha peut etre vu comme le vestige d'une interaction a tres courte distance (haute energie) entre les particules du systeme. Finalement, on montre que le groupe de symetrie du systeme avec extension auto -adjointe n'est plus SO(2,1) car le generateur de dilatation de ce groupe n'est plus compatible avec un parametre alpha arbitraire. (Abstract shortened by UMI.).

Dimensionnement des actionneurs électriques alimentés à fréquence variable sous faible tension

NASA Astrophysics Data System (ADS)

Biedinger, J.-M.; Vilain, J.-P.

1999-09-01

In Part I we present a multidisciplinary analysis model for the prediction of functional connections between the design variables and the electromagnetical, electrical and thermal performances of a brushless permanent magnet motor. In this paper we have elaborated a design methodology for electrical motors supplied from a variable-frequency low-voltage source. The objective is to take into account the influence of the inverter's dynamics from the beginning of the design, for the same reasons as we do for electromechanical and thermal constraints. The procedure is based on a Sequential Quadratic Programming optimization method. Two techniques are used to take into account the influence of the inverter: the first one develops the performance analysis with the multidisciplinary model; the second one considers the inverter's current reference as a supplementary optimization variable for the control of the design. Optimization difficulties linked to the chopping of the converter are discuted in connection with a sensitivity analysis of the torque, with respect to the inverter's current reference; a method is proposed to enhance the performances of the algorithm. The method has been applied to the design of a permanent magnet brushless DC motor used in the propulsion system of an electrical scooter; evolution of the design with the complexity level of analysis model is evidenced. Dans une première partie nous avons développé un modèle d'analyse pluridisciplinaire qui établissait les dépendances fonctionnelles entre les variables de conception et les performances magnéto-électro-thermiques d'un moteur brushless à aimants permanents. Dans cet article nous décrivons une procédure de dimensionnement adaptée à la conception de la machine alimentée à fréquence variable sous faible tension. L'objectif est d'intégrer la dynamique du convertisseur électronique dès la phase initiale du dimensionnement, au même titre que les spécifications électromécaniques et thermiques. La procédure est gérée par une méthode d'optimisation déterministe de type Programmation Quadratique Séquentielle. Elle intègre l'influence du convertisseur au moyen de deux spécificités : la première consiste à évaluer les fonctions du problème d'optimisation sur la base du module d'analyse pluridisciplinaire ; la deuxième permet de contrôler l'évolution du dimensionnement au travers de variables d'optimisation dont la liste inclut les consignes de la commande en courant du convertisseur. Les difficultés d'optimisation liées au mode de fonctionnement discret du convertisseur sont discutées au regard du calcul de la sensibilité du couple électromagnétique envers la consigne de courant du convertisseur ; une méthode est proposée pour assurer la robustesse de la procédure en présence du convertisseur. L'application porte sur le dimensionnement d'un moteur à aimants permanents de type “brushless trapézoïdal" destiné à la traction d'un scooter électrique ; l'évolution de la structure optimale avec le degré de complexité du module d'analyse est mise en évidence.

Syndrome de larva migrans cutanée sur pied malformé (à propos d'un cas)

PubMed Central

Benbella, Imane; Khalki, Hanane; Lahmadi, Khalid; Kouara, Sara; Abbadi, Abderrahim; Er-rami, Mohammed

2016-01-01

Le syndrome de larva migrans cutanée est une dermite sous cutanée causée par des larves d'ankylostomes d'animaux en impasse parasitaire chez l'homme. L'infestation transcutanée est favorisée par le contact avec le sol contaminé par les larves du parasite. Nous rapportons le cas d'un nourrisson de 15 mois, originaire de Guinée-Bissau, atteint d'un syndrome de larva migrans cutanée sur un pied malformé. Cette malformation sous forme d'une syndactylie associée à une tuméfaction du pied, était à l'origine d'un retard d'acquisition de la station debout. De même, on a rapporté une notion de pieds nus, vue la difficulté de chausser le pied malformé du patient. Tous ces facteurs auraient contribués à favoriser l'infestation du malade par les larves du nématode. PMID:27217876

Kyste épidermoïde du testicule : Étude de cas

PubMed Central

Diarra, Alkadri; Elammari, Jalal Eddine; Kassogue, Amadou; El Fassi, Mohammed Jamal; Farih, My Hassan

2013-01-01

Résumé Le kyste épidermoïde (KE) du testicule est une tumeur bénigne rare. Le diagnostic peut être évoqué par l’échographie et l’IRM. En cas de lésion unique de petite taille, il est possible d’effectuer une chirurgie conservatrice. Ce traitement nécessite une confirmation anatomopathologique. Le présent article fait état de l’observation d’un patient de 34 ans ayant été admis en consultation d’urologie pour désir d’enfant. Le diagnostic de KE associé à une varicocèle gauche a été retenu. L’énucléation du kyste avec cure de varicocèle a été réalisée sans complications postopératoires. Une revue de la littérature nous a permis de mettre en évidence les différents aspects du KE du testicule et les méthodes thérapeutiques envisageables. PMID:24282476

Assessment of depleted uranium in South-Western Iran.

PubMed

Yousefi, Hossein; Najafi, Abdullah

2013-10-01

Depleted uranium (DU) has been used in a number of conflicts most notably during the Gulf War in Iraq and existence of it has been reported in Kuwait by IAEA experts. Due to heavy sand storms prevailing into the direction to South West of Iran transporting sand originating from Iraq, the probability that DU could be moved is considered high. Therefore it was decided to take some air and soil samples near border line and some nearest cities. The study was focused on finding DU in air and soil of these south-west provinces. 22 air samples and 20 soil samples were collected and analyzed on their contents of uranium isotopes by alpha, beta and gamma spectrometry. The air and soil samples have been measured by use of an alpha-beta counter and by a gamma spectrometer, respectively. Results showed that there is no radiation impact from DU and so no DU has been transported via sand storms since all results were obtained below the detection limit. Copyright © 2013 Elsevier Ltd. All rights reserved.

Proteomic Prediction of Breast Cancer Risk: A Cohort Study

DTIC Science & Technology

2007-03-01

Total 1728 1189 68.81 (c) Data processing. Data analysis was performed using in-house software (Du P , Angeletti RH. Automatic deconvolution of...isotope-resolved mass spectra using variable selection and quantized peptide mass distribution. Anal Chem., 78:3385-92, 2006; P Du, R Sudha, MB...control. Reportable Outcomes So far our publications have been on the development of algorithms for signal processing: 1. Du P , Angeletti RH

W.E.B. Du Bois and Filipino/a American Exposure Programs to the Philippines: Race Class Analysis in an Epoch of "Global Apartheid"

ERIC Educational Resources Information Center

Viola, Michael Joseph

2016-01-01

The article highlights the ongoing relevance of W.E.B. Du Bois for the global analysis of race and class. Engaging scholarly debates that have ensued within the educational subfields of critical race theory (CRT) and (revolutionary) critical pedagogy, the article explores how a deeper engagement with Du Bois's ideas contributes theoretically and…

Actes du colloque sur le bilinguisme, Universite de Neuchatel, 14/15 Septembre, 1981 (Proceedings of the Colloquium on Bilingualism, University of Neuchatel, September 14-15, 1981).

ERIC Educational Resources Information Center

TRANEL, 1982

1982-01-01

This issue contains proceedings of a colloquium on linguistics at the University of Neuchatel: (1) "Propositions epistemologiques pour une etude du bilinguisme (Epistemological Propositions for a Study of Bilingualism)," by B. Py; (2) "Comment on di ca? Prolegomenes a une etude de la composante semantique du langage des migrants (How Do You Say…

Trans World Tidal Gravity Profile.

DTIC Science & Technology

1984-12-31

UTSJOVI - SURF,.BUILD, OLD CONCRETE PILLAR ON tEDPOCKMIGHATITE 2.71 GEODEETTIt.EN LAITOS HELSINKI JKAKKUPI GNEISSOSE GPANITE CATEDPA DE ASTRONOMIA Y ...EOCENE DE BRUXELLES SUR LE CAMBRIEN DU MASSIF DU BRABANT. SABLES LUTETIENS. ObSERVATOIRE ROYAL DE BELGIQUE DEPT.1 P.’MELCHIOR , INSTITUTO DI ASTRONOMIA Y ...SUP LE CAMBRIEN DU MASSIF CU BRABANT* SABLES LUTETIENS, -. OBSERVATOIRE ROYAL CE EELGIQUE DEPTe1 P.MELCHIOP INSTITUTO DI ASTRONOMIA Y GEODESIA DEL

Le syndrome du canal d’Alcock ou névralgie pudendale : un diagnostic à ne pas méconnaître

PubMed Central

Ziouziou, Imad; Bennani, Hassan; Zizi, Mohamed; Karmouni, Tarik; Khader, Khalid El; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

2013-01-01

Résumé Le syndrome du canal d’Alcock – ou névralgie pudendale – est lié à la compression chronique du nerf pudendal dans la fossette ischiorectale ou au niveau du ligament sacroépineux. Le diagnostic du syndrome d’Alcock est surtout clinique. Les examens complémentaires sont dominés par les explorations électrophysiologiques et le test de bloc anesthésique. Le diagnostic repose sur des critères bien précis, soit les critères de Nantes. La prise en charge doit être globale, comprenant un traitement médicamenteux, des infiltrations, des techniques de neuromodulation, et dans les cas graves ou résistants, un traitement chirurgical qui consiste à libérer le nerf pudendal. Les névralgies pudendales peuvent être rencontrées après traitement d’une incontinence urinaire d’effort par bande-lettes sous-urétrales (TVT). Ce syndrome motive des consultations en urologie, car la douleur intéresse le territoire du périnée et des organes génitaux. Des signes urinaires peuvent aussi accompagner cette douleur. Il est donc judicieux de connaître cette pathologie. PMID:23914265

[Risk Assessment of Heavy Metal Contamination in Farmland Soil in Du'an Autonomous County of Guangxi Zhuang Autonomous Region, China].

PubMed

Wu, Yang; Yang, Jun; Zhou, Xiao-yong; Lei, Mei; Gao, Ding; Qiao, Peng-wei; Du, Guo-dong

2015-08-01

For a comprehensive understanding of the pollution characteristics and ecological risk of heavy metals of farmland soil in Du'an Autonomous County of Guangxi Zhuang Autonomous Region, China, this study evaluated the cadmium (Cd), arsenic (As), nickel (Ni), zinc (Zn), chromium (Cr), antimony (Sb), copper (Cu) and lead ( Pb) pollution situation using the single factor index, the Nemerow pollution index and the Hakanson ecological risk index. The results showed that heavy-metal pollution of farmland soil in Du'an County was serious. 74.6% of the soil samples had heavy metals concentrations higher than the Grade II of National Soil Environmental Quality Standard (GB 15618-1995). The over standard rates of Cd, As, Ni, Zn, Cr, Sb, Cu, Pb were 70.6%, 42.9%, 34.9%, 19.8%, 19.6%, 2.94%, 1.59%, 0.79%, respectively. Cd and As were the main contaminants in Du'an County, the pollution was far more serious than those of the national and Guangxi Zhuang Autonomous Region. In terms of the ecological risk, heavy metals of farmland soil in Du'an County showed a "middle" ecological risk, with Cd accounting for 88% of the total ecological risk. The north-west of Jiudu Town and the zone between Bao'an Town and Dongmiao Town were two areas with high ecological risk in Du'an County. The contamination of farmland soils in Du'an County was caused by two main sources, whereas the pollution of As and Sb of farmland soils near Diaojiang River was mainly caused by the upstream mining industry.

Aspects épidémiologiques des traumatismes du rachis: à propos de 139 cas

PubMed Central

Bemora, Joseph Synèse; Rakotondraibe, Willy Francis; Ramarokoto, Mijoro; Ratovondrainy, Willy; Andriamamonjy, Clément

2017-01-01

Les traumatismes du rachis représentent une des lésions les plus fréquemment observées, chez les victimes d’accidents de circulation, d’accident de sportifs, domestique et du travail. Il s’agissait d’une étude rétrospective de 3 ans portant sur 139 cas de traumatismes du rachis hospitalisés et pris en charge dans le service de neurochirurgie du CHUJRA Madagascar. A travers cette étude, 25,17% des traumatisés étaient entre 21 et 30 ans avec une nette prédominance masculine de 69,78% (sexe ratio 2,3). L’étiologie était dominéepar la chute dans 33,09% des cas avec des facteurs de risque dont prise d’alcool (8,63%). Le traumatisme entrait dans le cadre d’un polytraumatisme dont un traumatisme crânien dans 34,63%. Les patients étaient admis dans le service 1 à 5h après le traumatisme dans 31,65% en utilisant comme moyen de transport une voiture personnelle dans 36,69%. Pendant l’hospitalisation 20 patients ont signé une décharge et 6,34% des patients sont décédés. Les traumatismes du rachis posent un problème de santé publique avec une prise en charge lourde surtout pour les patients déficitaires à vie. Devant tout traumatisme du rachis, il faut rechercher systématiquement une lésion crânienne. PMID:28450995

Anti-inflammatory and carbonic anhydrase restoring actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced duodenal ulcer in a rat model.

PubMed

Park, Jong-Min; Kim, Yoon-Jae; Kim, Ju-Seung; Han, Young-Min; Kangwan, Napapan; Hahm, Ki Baik; Kim, Tae-Sok; Kwon, Oran; Kim, Eun-Hee

2013-08-01

Increased acid output, accompanied with a defective defense system, is considered a fundamental pathogenesis of duodenal ulcer (DU). However, relapse of DU occurs despite proton pump inhibitors and H2 receptor antagonists, hence imposing the enforcement of the defense system. Dried powder of the yam tuber (Dioscorea spp) has been used in traditional folk medicine as a nutritional fortification. We hypothesized that dried-yam powder would prevent DU through improvement of anti-inflammatory actions and carbonic anhydrase (CA) activity. Therefore, we investigated the preventive effects of dried-yam powder against the cysteamine-induced DU and elucidated the underlying mechanisms. Duodenal ulcers were induced in Sprague-Dawley rats by intragastric administration of 500 mg/kg cysteamine-HCl. The dried-yam powder was used as a pretreatment before the cysteamine-HCl. The number and size of DU were measured. The expressions of inflammation mediators were checked in duodenal tissues, and the expressions of CAs and malondialdehyde levels were also examined. Cysteamine provoked perforated DU, whereas dried-yam powder significantly prevented DU as much as pantoprazole and significantly reduced the incidence of perforation. The messenger RNA expressions of cyclooxygenase-2 and inducible nitric oxide synthase were remarkably decreased in the yam group compared with the cysteamine group, and the serum levels of proinflammatory cytokines including interleukin-1β, interleukin-6, and tumor necrosis factor were significantly attenuated in the yam group. Cysteamine significantly decreased the expression of CAs, whereas yam treatment significantly preserved the expressions of CA IX, XII, and XIV. In conclusion, dried-yam powder exerts a significant protective effect against cysteamine-induced DU by lowering the activity of inflammatory cytokines and free radicals and restoring the activity of CAs, except in CA IV. Copyright © 2013 Elsevier Inc. All rights reserved.

[Effect of electroacupuncture of "Xiaohai" (SI 8) and "Xiajuxu" (ST 39) on serum TNF-α and duodenal high mobility group protein B 1 levels in duodenal ulcer rats].

PubMed

Zhang, Hong; Wang, Zhen-zhen; Zhang, Yu-chen; Yang, Lu-jia; Deng, Shi-feng; Ai, Kun; Zhang, Zhi-ping

2015-02-01

To observe the effect of electroacupuncture (EA) stimulation of "Xiaohai" (SI 8) and "Xiajuxu" (ST 39) on serum TNF-α and duodenal high mobility group protein B 1 (HMGB 1) levels in rats with duodenal ulcer (DU), so as to analyze its underlying mechanism in improving DU. Forty SD rats were randomly divided into normal control, model, Xiaohai (SI 8) and Xiajuxu (ST 39) groups (n=10 in each group). The DU model was established by intramuscular injection of 10% Cysteamine hydrochloride (300 mg/kg), followed by taking water containing 1% Cysteamine hydrochloride for 48 h. EA (10 Hz/50 Hz, 1-3 mA) was applied to bilateral SI 8 and ST 39 for 30 min, once a day for 10 days. The DU score (0-5 score) was evaluated according to Moraes' method. Serum TNF-α content was determined by ELISA and duodenal HMGB 1 expression was measured by immunohistochemistry. Compared to the normal control group, the DU score, serum TNF-α content, and duodenal HMGB 1 expression level of the model group were significantly higher (P<0.01). Following EA intervention, the increased DU score, serum TNF-α content, and duodenal HMGB 1 expression level were considerably down-regulated in the two EA groups in comparison with the model group (P<0.01, P<0.05) except HMGB 1 in the SI 8 group (P>0.05), and the effect of EA of "Xiajuxu" (ST 39), the lower-He point, was remarkably superior to that of "Xiaohai" (SI 8) in reducing DU score and TNF-α content (P<0.01). EA stimulation of SI 8 and ST 39 can improve duodenal ulceration in DU rats, which may be related to its effect in down-regulating serum TNF-α and duodenal HMGB 1 expression. The therapeutic effect of ST 39 is markedly better than SI 8 in relieving duodenal ulceration.

Physicochemical Characterization of Capstone Depleted Uranium Aerosols III: Morphologic and Chemical Oxide Analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krupka, Kenneth M.; Parkhurst, MaryAnn; Gold, Kenneth

2009-03-01

The impact of depleted uranium (DU) penetrators against an armored target causes erosion and fragmentation of the penetrators, the extent of which is dependent on the thickness and material composition of the target. Vigorous oxidation of the DU particles and fragments creates an aerosol of DU oxide particles and DU particle agglomerations combined with target materials. Aerosols from the Capstone DU aerosol study, in which vehicles were perforated by DU penetrators, were evaluated for their oxidation states using X-ray diffraction (XRD) and particle morphologies using scanning electron microscopy/energy dispersive spectrometry (SEM/EDS). The oxidation state of a DU aerosol is importantmore » as it offers a clue to its solubility in lung fluids. The XRD analysis showed that the aerosols evaluated were a combination primarily of U3O8 (insoluble) and UO3 (relatively more soluble) phases, though intermediate phases resembling U4O9 and other oxides were prominent in some samples. Analysis of particle residues in the micrometer-size range by SEM/EDS provided microstructural information such as phase composition and distribution, fracture morphology, size distribution, and material homogeneity. Observations from SEM analysis show a wide variability in the shapes of the DU particles. Some of the larger particles appear to have been fractured (perhaps as a result of abrasion and comminution); others were spherical, occasionally with dendritic or lobed surface structures. Amorphous conglomerates containing metals other than uranium were also common, especially with the smallest particle sizes. A few samples seemed to contain small chunks of nearly pure uranium metal, which were verified by EDS to have a higher uranium content exceeding that expected for uranium oxides. Results of the XRD and SEM/EDS analyses were used in other studies described in this issue of The Journal of Health Physics to interpret the results of lung solubility studies and in selecting input parameters for dose assessments.« less

Implanted depleted uranium fragments cause soft tissue sarcomas in the muscles of rats.

PubMed Central

Hahn, Fletcher F; Guilmette, Raymond A; Hoover, Mark D

2002-01-01

In this study, we determined the carcinogenicity of depleted uranium (DU) metal fragments containing 0.75% titanium in muscle tissues of rats. The results have important implications for the medical management of Gulf War veterans who were wounded with DU fragments and who retain fragments in their soft tissues. We compared the tissue reactions in rats to the carcinogenicity of a tantalum metal (Ta), as a negative foreign-body control, and to a colloidal suspension of radioactive thorium dioxide ((232)Th), Thorotrast, as a positive radioactive control. DU was surgically implanted in the thigh muscles of male Wistar rats as four squares (2.5 x 2.5 x 1.5 mm or 5.0 x 5.0 x 1.5 mm) or four pellets (2.0 x 1.0 mm diameter) per rat. Ta was similarly implanted as four squares (5.0 x 5.0 x 1.1 mm) per rat. Thorotrast was injected at two sites in the thigh muscles of each rat. Control rats had only a surgical implantation procedure. Each treatment group included 50 rats. A connective tissue capsule formed around the metal implants, but not around the Thorotrast. Radiographs demonstrated corrosion of the DU implants shortly after implantation. At later times, rarifactions in the radiographic profiles correlated with proliferative tissue responses. After lifetime observation, the incidence of soft tissue sarcomas increased significantly around the 5.0 x 5.0 mm squares of DU and the positive control, Thorotrast. A slightly increased incidence occurred in rats implanted with the 2.5 x 2.5 mm DU squares and with 5.0 x 5.0 mm squares of Ta. No tumors were seen in rats with 2.0 x 1.0 mm diameter DU pellets or in the surgical controls. These results indicate that DU fragments of sufficient size cause localized proliferative reactions and soft tissue sarcomas that can be detected with radiography in the muscles of rats. PMID:11781165

Cholestéatome du méat acoustique externe

PubMed Central

Azeddine, Lachkar; Aabach, Ahmed; Chouai, Mohamed; Elayoubi, Fahd; Ghailan, Mohamed Rachid

2016-01-01

Le cholestéatome du méat acoustique externe se définit comme une accumulation de kératine en regard d’une érosion osseuse de nature ostéitique. C’est une entité otologique rare ou peut diagnostiquée. Le but de notre travail est d’illustrer sur la base d’un cas un cholestéatome du méat acoustique externe. Il s’agit d’un patient âgé de 65 ans diabétique et hypertendu sous traitement, présentant depuis 3 mois une otalgie droite intense, insomniante, avec hypoacousie, otorrhée purulente minime et paralysie faciale droite grade V. Le diagnostic évoqué était dans un premier temps celui d’otite externe maligne. Il a été mis sous traitement antibiotique sans amélioration. L’examen otologique a trouvé une lésion ulcéro-bourgeonnante de la paroi postérieure du méat acoustique externe droit, une biopsie systématique de la lésion a été pratiquée et a conclu à un cholestéatome. Le patient a bénéficié d’une tympanoplastie en technique ouverte. Le cholestéatome du méat acoustique externe est rare, la symptomatologie clinique n’est pas spécifique, le scanner des rocher est d’un grand apport pour le diagnostic positif montrant un cratère osseux du méat acoustique externe. Le traitement dépend de l’extension des lésions allant des simples soins locaux à une tympanoplastie en technique ouverte. Le cholestéatome du méat acoustique externe peut revêtir plusieurs aspects, et prêter confusion avec d’autres pathologies du méat acoustique externe. PMID:28154624

Partial purification and characterization of bacteriocin produced by Enterococcus faecalis DU10 and its probiotic attributes.

PubMed

Perumal, Venkatesh; Repally, Ayyanna; Dasari, Ankaiah; Venkatesan, Arul

2016-10-02

A novel bacteriocin produced by avian duck isolated lactic acid bacterium Enterococcus faecalis DU10 was isolated. This bacteriocin showed a broad spectrum of antibacterial activity against important food-borne pathogens and was purified by size exclusion chromatography followed by reverse-phase high-performance liquid chromatography in a C-18 column. Tricine-SDS PAGE revealed the presence of a band with an estimated molecular mass of 6.3 kDa. The zymogram clearly linked the antimicrobial activity with this band. This result was further confirmed by mass-assisted laser desorption ionization time-of-flight mass spectrometry, since a sharp peak corresponding to 6.313 kDa was detected and the functional groups were revealed by Fourier transform infrared spectroscopy. Bacteriocin DU10 activity was found sensitive to proteinase-K and pepsin and partially affected by trypsin and α-chymotrypsin. The activity of bacteriocin DU10 was partially resistant to heat treatments ranging from 30 to 90°C for 30 min. It also withstood a treatment at 121°C for 10 min. Cytotoxicity of bacteriocin DU10 by methyl-thiazolyl-diphenyl-tetrazolium bromide assay showed that the viability of HT-29 and HeLa cells decreased 60 ± 0.7% and 43 ± 4.8%, respectively, in the presence of 3,200 AU/mL of bacteriocin. The strain withstood 0.3% w/v of bile oxgall and pH 2 affected the bacterial growth between 2 and 4 hr of incubation. Adhesion properties examined with HT-29 cell line showed 69.85% initial population of strain E. faecalis DU10, which was found to be strongly adhered to this cell line. These results conclude bacteriocin DU10 may be used as a potential biopreservative and E. faecalis DU10 may be used as a potential probiont to control Salmonella infections.

Analyse de la dégradation thermique du Poly(éther éther cétone)

NASA Astrophysics Data System (ADS)

Courvoisier, Emilie; Bicaba, Yoann; Colin, Xavier

2018-03-01

La dégradation thermique du PEEK a été étudiée à l'état caoutchoutique dans de larges intervalles de température (entre 180 et 320 °C) et de pression partielle d'oxygène (entre 0,21 et 50 bars). Tout d'abord, les mécanismes de vieillissement thermique ont été analysés et élucidés par spectroscopie IRTF et par calorimétrie différentielle (DSC) sur des films de PEEK suffisamment minces (entre 10 et 60 μm d'épaisseur) pour s'affranchir totalement des effets de la diffusion d'oxygène. L'oxydation se produit sur les cycles aromatiques provoquant la croissance de cinq nouvelles bandes d'absorption IR centrées à 3650, 3525, 1780, 1740 et 1718 cm-1 et attribuées aux vibrations d'élongation des liaisons O-H du phénol et de l'acide benzoïque, et des liaisons C-O de l'anhydride benzoïque, du benzoate de phényle et de la fluorénone respectivement. De plus, l'oxydation conduit à une large prédominance de la réticulation sur les coupures de chaîne (augmentation de Tg) empêchant le recuit du PEEK, en particulier lorsque la température d'exposition est supérieure au pied du pic de fusion. Enfin, les conséquences de l'oxydation sur les propriétés élastiques ont été analysées et élucidées par micro-indentation sur des sections droites préalablement polies de plaquettes de PEEK de 3 mm d'épaisseur. Les variations du module d'Young et du taux de cristallinité se corrèlent parfaitement, vérifiant ainsi la relation de Tobolsky.

Élimination du bore du silicium par plasma inductif sous champ électrique

NASA Astrophysics Data System (ADS)

Combes, R.; Morvan, D.; Picard, G.; Amouroux, J.

1993-05-01

We analyzed purification mechanisms of silicon by inductive plasma with a fluoride slag. The aim is to study boron elimination from doped electronic grade silicon in function of the nature of the slag to obtain a photovoltaic grade silicon. The steady began with the calculation and the comparison of the stability diagram of boron compounds in presence of CaF2, BaF2 and MgF2. This study led us to conclude that BaF2 is the better slag for silicon purification. This has been confirmed by experience. In a second time, we made purifications under electric bias to enhance slag efficiency. We noticed that BaF2 is more sensitive to electric bias than other slags. Nous avons analysé le mécanisme de purification du silicium sous plasma inductif en présence d'un laitier fluoré. L'objectif principal est d'étudier l'élimination du bore du silicium électronique dopé en fonction de la nature du fluorure pour obtenir un silicium de qualité photovoltaïque. L'étude a commencé par l'établissement et la comparaison de diagrammes des composés du bore en présence de CaF2, de MgF2 et de BaF2. Nous avons déduit de cette première étude que BaF2 est le meilleur laitier pour la purification du silicium. Ceci a été corroboré par l'expérience. Nous avons ensuite opéré en présence d'un champ électrique dans le but d'améliorer encore l'efficacité des laitiers. Nous avons constaté que BaF2 est plus sensible au champ électrique que les deux autres laitiers utilisés.

Cirque du Monde as a health intervention: perceptions of medical students and social circus experts.

PubMed

Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

2014-11-01

To present Cirque du Soleil's social circus program, Cirque du Monde, to explore its potential as a primary health care tool for family physicians. A review of the literature in PubMed, the Cochrane Library, PsycINFO, LaPresse, Eureka, Google Scholar, and Érudit using the key words circus, social circus, Cirque du Monde, and Cirque du Soleil; a Montreal-based initiative, Espace Transition, modeled on Cirque du Monde; and personal communication with Cirque du Soleil's Social Circus Training Advisor. The first 50 articles or websites identified for each key word in each of the databases were examined on the basis of their titles and abstracts in the case of articles, and on the basis of their titles and page content in the case of websites. Articles and websites that explored an aspect of social circuses or that described an intervention that involved circuses were then retained for analysis. Because all literature on social circuses was searched, no criterion for year of publication was used. No articles on the social circus as a health intervention were found. One study on the use of the circus as an intervention in schools was identified. It demonstrated an increase in self-esteem in the children who took part. One study on the use of the circus in a First Nations community was found; it contained nonspecific, qualitative findings. The other articles identified were merely descriptions of social circuses. One website was identified on the use of the social circus to help youth who had been treated in a hospital setting for major psychiatric disorders to re-enter the community. The team in the pediatric psychiatry department at Centre Hospitalier Universitaire Sainte-Justine, the children's hospital in Montreal, Que, was contacted; they were leading this project, called Espace Transition. The unpublished preliminary findings of its pilot project demonstrate substantial improvements in overall patient functioning. According to Cirque du Soleil, there are several projects under way around the world researching the therapeutic value of social circuses. Cirque du Monde is able to reach a marginalized population that is otherwise difficult for the health system to reach. This program has therapeutic potential because of its target population, its promotion of healthy habits, and the support that it offers through the group and its workers. Cirque du Soleil is investing heavily in this project. The lack of literature yielding robust data on the social circus is therefore an important issue. Copyright© the College of Family Physicians of Canada.

Cirque du Monde as a health intervention

PubMed Central

Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

2014-01-01

Abstract Objective To present Cirque du Soleil’s social circus program, Cirque du Monde, to explore its potential as a primary health care tool for family physicians. Data sources A review of the literature in PubMed, the Cochrane Library, PsycINFO, LaPresse, Eureka, Google Scholar, and Érudit using the key words circus, social circus, Cirque du Monde, and Cirque du Soleil; a Montreal-based initiative, Espace Transition, modeled on Cirque du Monde; and personal communication with Cirque du Soleil’s Social Circus Training Advisor. Study selection The first 50 articles or websites identified for each key word in each of the databases were examined on the basis of their titles and abstracts in the case of articles, and on the basis of their titles and page content in the case of websites. Articles and websites that explored an aspect of social circuses or that described an intervention that involved circuses were then retained for analysis. Because all literature on social circuses was searched, no criterion for year of publication was used. Synthesis No articles on the social circus as a health intervention were found. One study on the use of the circus as an intervention in schools was identified. It demonstrated an increase in self-esteem in the children who took part. One study on the use of the circus in a First Nations community was found; it contained nonspecific, qualitative findings. The other articles identified were merely descriptions of social circuses. One website was identified on the use of the social circus to help youth who had been treated in a hospital setting for major psychiatric disorders to re-enter the community. The team in the pediatric psychiatry department at Centre Hospitalier Universitaire Sainte-Justine, the children’s hospital in Montreal, Que, was contacted; they were leading this project, called Espace Transition. The unpublished preliminary findings of its pilot project demonstrate substantial improvements in overall patient functioning. According to Cirque du Soleil, there are several projects under way around the world researching the therapeutic value of social circuses. Conclusion Cirque du Monde is able to reach a marginalized population that is otherwise difficult for the health system to reach. This program has therapeutic potential because of its target population, its promotion of healthy habits, and the support that it offers through the group and its workers. Cirque du Soleil is investing heavily in this project. The lack of literature yielding robust data on the social circus is therefore an important issue. PMID:25392449

Two-generation reproductive toxicity study of implanted depleted uranium (DU) in CD rats.

PubMed

Arfsten, D P; Still, K R; Wilfong, E R; Johnson, E W; McInturf, S M; Eggers, J S; Schaeffer, D J; Bekkedal, M Y-V

2009-01-01

Depleted uranium (DU) munitions and armor plating have been used in several conflicts over the last 17 yr, including the Persian Gulf War and the Iraq War. Because of its effectiveness and availability, DU will continue to be used in military applications into the foreseeable future. There is much controversy over the use of DU in weapons and equipment because of its potential radiological and toxic hazards, and there is concern over the chronic adverse health effects of embedded DU shrapnel in war veterans and bystanders. This study evaluated the effects of long-term implantation of DU on the reproductive success of F0 generation adults and development and survival of subsequent F1 and F2 generations in a two-generation reproductive toxicity study. F0 generation Sprague-Dawley rats, 8 wk of age, were surgically implanted with 0, 4, 8, 12, or 20 DU pellets (1 x 2 mm). Inert implant control animals were implanted with 12 or 20 tantallum (Ta) pellets. The F0 generation was then mated at 120 d post DU implantation. In the F0 generation, when measured on postimplantation d 27 and 117, uranium was present in the urine of DU-implanted animals in a dose-dependent manner. F0 reproductive success was similar across treatment groups and the maternal retrieval test revealed no changes in maternal behavior. DU implantation exerted no effect on the survival, health, or well-being of the F0 generation. Necropsy results of F0 animals were negative with the exception of a marked inflammatory response surrounding the implanted DU pellets. For the F1 generation, measures of F1 development through postnatal day (PND) 20 were unremarkable and no gross abnormalities were observed in F1 offspring. No uranium was detected in whole-body homogenates of PND 4 or PND 20 pups. Necropsy findings of F1 PND 20 pups were negative and no instances of ribcage malformation were observed in F1 PND 20 pups. Body weight and body weight gain of F1 rats through PND 120 were similar across treatment groups. Eight of 414 F1 animals observed from PND 20 to 120 died of unknown causes; 7 were from litters of DU-implanted F0 mating pairs. F1 mating success at 10 wk of age was an overall 70% compared with 91% for F0 mating pairs. Mating success was similar between F1 animals derived from DU-implanted F0 adults and those derived from F0 implant control adults suggesting that the comparatively low mating success was not due to F1 DU exposure. The gestational index of F1 animals derived from mid-dose F0 mating pairs was found to be lower compared with F1 controls. The average gestation duration of F1 animals derived from high-dose F0 mating pairs was found to be significantly longer than F1 controls. F1 sperm motility analyses did not differ among experimental groups and no gross abnormalities were identified at necropsy among surviving F1 animals at PND 120. Histopathology of kidneys, spleen, thymus, bone marrow, ovaries, and testes of F1 high-dose animals did not differ from F1 controls. F1 high-dose females had significantly higher mean relative liver and heart weights compared with F1 controls; the biological relevance of this finding could not be determined. For the F2 generation, measures of F2 development through PND 20 were unremarkable and no gross abnormalities were observed in F2 offspring. Necropsy findings of F2 PND 20 pups were negative and no instances of ribcage malformation were observed in F2 PND 20 pups. Body weight and body weight gain of F2 rats through PND 90 were similar across treatment groups. Mean relative heart weights of males derived from high-dose F0 parents were significantly lower compared with F2 controls. Sperm motility and concentration analysis of F2 males at PND 90 were similar across F2 groups. Overall, the consistent absence of positive findings in this study seems to suggest that DU is not a significant reproductive or developmental hazard, particularly when one considers that mid- and high-dose rats were implanted with the equivalent of 0.3 and 0.5 lb of DU in a 70-kg human, respectively. However, the findings that seven of eight F1 adults that died postweaning were from DU-implanted F0 mating pairs, and that mean relative heart weights were elevated in high-dose F1 and F2 pups, suggest conservatism is warranted in characterizing the reproductive and teratogenic hazards of embedded DU until further studies are completed.

Issues in Intelligence Production: Summary of Interviews with Canadian Managers of Intelligence Analysts

DTIC Science & Technology

2010-12-01

la Reine (en droit du Canada), telle que représentée par le ministre de ...organisationnelles, ainsi qu’aux préjugés des analystes et des organismes du renseignement. Un tel constat exige la tenue d’un examen en profondeur de la ...processus de production du renseignement que l’on pourrait expliquer par la mise en application des connaissances et des méthodes acquises dans

The Management of Ethnic-Cultural Diversity in Western Armed Forces

DTIC Science & Technology

2012-03-20

192-201. 12 Bruce A. Brant, ―Vanguard of Social Change?‖ Military Review, no. 73 (February 1993): 12-19. 13 Histoire du monde Home Page, http...11, 2008. http://inde.aujourdhuilemonde.com/les-separatistes-gorkhas-entament-un-blocus- general?page=7 (accessed January 25, 2012). 15 ― Histoire ...du monde Home Page, http://www.histoiredumonde.net/Gurkhas.html (accessed January 25, 2012). 16 Histoire du monde Home Page, http

The W. E. B. DuBois and Booker T. Washington Debate: Effects upon African American Roles in Engineering and Engineering Technology

ERIC Educational Resources Information Center

Johnson, Keith V.; Watson, Elwood

2004-01-01

The messages of Booker T. Washington and W. E. B. DuBois could not have been more diverse. The philosophical rivalry between Washington and DuBois has deep historical roots. To be on the same side fighting for the same purpose, progress, and uplifting of the Black race, these two Black intellectuals harbored radically divergent views on how to…

Distributed utility technology cost, performance, and environmental characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wan, Y; Adelman, S

1995-06-01

Distributed Utility (DU) is an emerging concept in which modular generation and storage technologies sited near customer loads in distribution systems and specifically targeted demand-side management programs are used to supplement conventional central station generation plants to meet customer energy service needs. Research has shown that implementation of the DU concept could provide substantial benefits to utilities. This report summarizes the cost, performance, and environmental and siting characteristics of existing and emerging modular generation and storage technologies that are applicable under the DU concept. It is intended to be a practical reference guide for utility planners and engineers seeking informationmore » on DU technology options. This work was funded by the Office of Utility Technologies of the US Department of Energy.« less

Mesure optimale de tilt et déplacement d'un faisceau gaussien

NASA Astrophysics Data System (ADS)

Delaubert, V.; Treps, N.; Fabre, C.; Harb, C.; Lam, P. K.; Bachor, H.

2006-10-01

Nous réalisons une expérience de mesure optimale de petits déplacements d'un faisceau gaussien TEM{00}, basée sur une détection homodyne employant un oscillateur local TEM{10}. Nous montrons une amélioration de 56% du signal détecté par rapport à une détection à deux zones. Ce nouveau dispositif permet également de mesurer de façon optimale de petites valeurs de tilt, la quantité conjuguée du déplacement. Enfin, nous montrons que la compression du mode TEM{10} du faisceau incident permet une mesure de déplacement au delà de la limite quantique standard.

Cost Structure and Life Cycle Cost (LCC) for Military Systems (structures de couts globaux de possession (LCC) pour systemes militaires)

DTIC Science & Technology

2003-06-01

variables. Dans le plan (p = 2), la méthode de régression linéaire ajuste au nuage de points une droite qui minimise la somme des écarts au carré entre...cohérence de la définition du produit. Par exemple, pour un blindé, il faut valider l ’ « harmonie » du trio masse, puissance du moteur et vitesse maximale. Il...en condition opérationnelle. De façon plus générale, la DGA devrait s’orienter vers l ‘élaboration et l’acquisition de modèle d’estimation de coûts du

Quels sont les problemes ethiques souleves par l’augmentation des capacites cognitives dans le cadre de la defense : cadre legal francais, position ethique du service de sante des armees francais

DTIC Science & Technology

2009-10-01

pourtant été systématisée. L’observation que, même si chaque homme est unique, il n’en partage pas moins un certain nombre de caractéristiques avec ses...occidental du comportement normal d’un homme , c’est-à-dire ce en deçà de quoi il ne peut déroger au risque de sortir du statut d’homme. Ainsi, le... de garantir les conditions de vie harmonieuse dans la société des hommes . Ainsi, l’éthique individuelle du citoyen français se niche dans un ensemble

Insomnia Symptoms and Risk for Unintentional Fatal Injuries—The HUNT Study

PubMed Central

Laugsand, Lars Erik; Strand, Linn B.; Vatten, Lars J.; Janszky, Imre; Bjørngaard, Johan Håkon

2014-01-01

Study Objectives: To assess the association between insomnia symptoms and risk of fatal unintentional injuries. Design: Population-based prospective cohort study with a mean follow-up of 14 y, linking health survey data with information on insomnia symptoms to the National Cause of Death Registry. Setting: Nord-Trøndelag County, Norway. Participants: A total of 54,399 men and women 20-89 y of age who participated in the Nord-Trøndelag Health Study between 1995 and 1997. Interventions: N/A. Measurements and results: There were 277 unintentional fatal injuries, including 57 fatal motor vehicle injuries during follow-up. There was a dose-dependent association between the number of insomnia symptoms and risk of unintentional fatal injuries (P for trend 0.001) and fatal motor vehicle injuries (P for trend 0.023), respectively. The proportion of unintentional fatal injuries cases that could have been prevented in the absence of difficulties initiating sleep, difficulties maintaining sleep, and having a feeling of nonrestorative sleep were 8%, 9%, and 8%, respectively. The corresponding estimates for motor vehicle injuries were 34%, 11%, and 10%. Conclusion: Insomnia is a major contributor to both unintentional fatal injuries in general as well as fatal motor vehicle injuries. Increasing public health awareness about insomnia and identifying persons with insomnia may be important in preventing unintentional fatal injuries. Citation: Laugsand LE, Strand LB, Vatten LJ, Janszky I, Bjørngaard JH. Insomnia symptoms and risk for unintentional fatal injuries—the HUNT Study. SLEEP 2014;37(11):1777-1786. PMID:25364073

Forecasts of health care utilization related to pandemic A(H1N1)2009 influenza in the Nord-Pas-de-Calais region, France.

PubMed

Giovannelli, J; Loury, P; Lainé, M; Spaccaferri, G; Hubert, B; Chaud, P

2015-05-01

To describe and evaluate the forecasts of the load that pandemic A(H1N1)2009 influenza would have on the general practitioners (GP) and hospital care systems, especially during its peak, in the Nord-Pas-de-Calais (NPDC) region, France. Modelling study. The epidemic curve was modelled using an assumption of normal distribution of cases. The values for the forecast parameters were estimated from a literature review of observed data from the Southern hemisphere and French Overseas Territories, where the pandemic had already occurred. Two scenarios were considered, one realistic, the other pessimistic, enabling the authors to evaluate the 'reasonable worst case'. Forecasts were then assessed by comparing them with observed data in the NPDC region--of 4 million people. The realistic scenarios forecasts estimated 300,000 cases, 1500 hospitalizations, 225 intensive care units (ICU) admissions for the pandemic wave; 115 hospital beds and 45 ICU beds would be required per day during the peak. The pessimistic scenario's forecasts were 2-3 times higher than the realistic scenario's forecasts. Observed data were: 235,000 cases, 1585 hospitalizations, 58 ICU admissions; and a maximum of 11.6 ICU beds per day. The realistic scenario correctly estimated the temporal distribution of GP and hospitalized cases but overestimated the number of cases admitted to ICU. Obtaining more robust data for parameters estimation--particularly the rate of ICU admission among the population that the authors recommend to use--may provide better forecasts. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Patterns of receptive and creative cultural activities and their association with perceived health, anxiety, depression and satisfaction with life among adults: the HUNT study, Norway.

PubMed

Cuypers, Koenraad; Krokstad, Steinar; Holmen, Turid Lingaas; Skjei Knudtsen, Margunn; Bygren, Lars Olov; Holmen, Jostein

2012-08-01

Cultural participation has been used both in governmental health policies and as medical therapy, based on the assumption that cultural activities will improve health. Previous population studies and a human intervention study have shown that religious, social and cultural activities predict increased survival rate. The aim of this study was to analyse the association between cultural activity and perceived health, anxiety, depression and satisfaction with life in both genders. The study is based on the third population-based Nord-Trøndelag Health Study (2006-2008), including 50,797 adult participants from Nord-Trøndelag County, Norway. Data on cultural activities, both receptive and creative, perceived health, anxiety, depression and satisfaction with life were collected by comprehensive questionnaires. The logistic regression models, adjusted for relevant cofactors, show that participation in receptive and creative cultural activities was significantly associated with good health, good satisfaction with life, low anxiety and depression scores in both genders. Especially in men, attending receptive, rather than creative, cultural activities was more strongly associated with all health-related outcomes. Statistically significant associations between several single receptive, creative cultural activities and the health-related outcome variables were revealed. This population-based study suggests gender-dependent associations between cultural participation and perceived health, anxiety, depression and satisfaction with life. The results support hypotheses on the effect of cultural activities in health promotion and healthcare, but further longitudinal and experimental studies are warranted to establish a reliable cause-effect relationship.

Paternal and maternal alcohol abuse and offspring mental distress in the general population: the Nord-Trøndelag health study

PubMed Central

2012-01-01

Background The degree to which parental alcohol abuse is a risk factor for offspring mental distress is unclear, due to conflicting results of previous research. The inconsistencies in previous findings may be related to sample characteristics and lack of control of confounding or moderating factors. One such factor may be the gender of the abusing parent. Also, other factors, such as parental mental health, divorce, adolescent social network, school functioning or self-esteem, may impact the outcome. This study examines the impact of maternal and paternal alcohol abuse on adolescent mental distress, including potentially confounding, mediating or moderating effects of various variables. Methods Data from the Nord-Trøndelag Health Study (HUNT), a Norwegian population based health survey, from 4012 offspring and their parents were analyzed. Parental alcohol abuse was measured by numerical consumption indicators and CAGE, whereas offspring mental distress was measured by SCL-5, an abbreviated instrument tapping symptoms of anxiety and depression. Statistical method was analysis of variance. Results Maternal alcohol abuse was related to offspring mental distress, whereas no effect could be shown of paternal alcohol abuse. Effects of maternal alcohol abuse was partly mediated by parental mental distress, offspring social network and school functioning. However, all effects were relatively small. Conclusions The results indicate graver consequences for offspring of alcohol abusing mothers compared to offspring of alcohol abusing fathers. However, small effect sizes suggest that adolescent offspring of alcohol abusing parents in general manage quite well. PMID:22708789

Gender differences in psychosocial functioning of adolescents with symptoms of anxiety and depression: longitudinal findings from the Nord-Trøndelag Health Study.

PubMed

Derdikman-Eiron, Ruth; Indredavik, Marit S; Bakken, Inger Johanne; Bratberg, Grete H; Hjemdal, Odin; Colton, Matthew

2012-11-01

To explore longitudinally gender differences in the associations between psychosocial functioning, subjective well-being and self-esteem among adolescents with and without symptoms of anxiety and depression. Data were obtained from a major population-based Norwegian study, the Nord-Trøndelag Health Study, in which 1,092 boys and 1,262 girls (86% of all invited) completed an extensive self-report questionnaire at baseline (mean age 14.4 years) and at follow-up (mean age 18.4 years). Gender was a moderator variable in the associations between symptoms of anxiety and depression and impairment, meaning that boys' functioning was impaired to a larger extent than girls' functioning. A statistically significant interaction effect between gender and symptoms of anxiety and depression was found at follow-up in terms of subjective well-being (p < 0.05), self-esteem (p < 0.05), academic problems (p < 0.01), behaviour problems (p < 0.01) and frequency of meeting friends (p < 0.001). Onset of symptoms between baseline and follow-up was associated with less frequent meetings with friends among boys, but not among girls. After remission of symptoms, boys still had more behaviour and academic problems, less frequently met friends and reported lower subjective well-being and self-esteem than boys who had no symptoms at both time points. No similar differences were found among the girls. Previous and ongoing symptoms of anxiety and depression had more negative consequences for boys than for girls. These findings may contribute to improved assessment and intervention methods tailored differently for each gender.

Prevalence of, and work-related risk factors for, hand eczema in a Norwegian general population (The HUNT Study).

PubMed

Vindenes, Hilde K; Svanes, Cecilie; Lygre, Stein H L; Hollund, Bjørg-Eli; Langhammer, Arnulf; Bertelsen, Randi J

2017-10-01

Chemical exposures at work and at home may cause hand eczema. However, this has been scarcely described for Norway. To investigate the prevalence of, and occupational risk factors for, hand eczema in Norway. Among 50 805 respondents (aged ≥20 years) to the third Nord-Trøndelag Health Study (HUNT3), 5757 persons reported ever having hand eczema, and 4206 answered a hand eczema questionnaire. The lifetime prevalences of hand eczema were 8.4% in men and 13.8% in women (p < 0.001), with onset at age ≤10 years in 24% (men) and 20% (women), and onset at age ≥30 years in 37% (men) and 25% (women) (p < 0.001). Work-related hand eczema affected 4.8% of the population, and was most frequently associated with health/social work (29%) and occupational cleaning (20%) in women, and with farming (26%) and industrial occupations (27%) in men. Cleaning detergents (75%) and other chemicals (36%) were the most common exacerbating factors. The prevalence of hand eczema was 11.3%, and that of work-related hand eczema was 4.8%. Hand eczema was more common in women than in men, but with a later onset in men. Cleaning detergents were the most common aggravating factors. A large proportion of the Nord-Trøndelag population is employed in farming, providing the possibility to identify farming as an important risk factor for hand eczema. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Admixture analysis in relation to pedigree studies of introgression in a minority British cattle breed: the Lincoln Red.

PubMed

Bray, T C; Hall, S J G; Bruford, M W

2014-02-01

Investigation of historic population processes using molecular data has been facilitated by the use of approximate Bayesian computation (ABC), which enables the consideration of multiple alternative demographic scenarios. The Lincoln Red cattle breed provides a relatively simple example of two well-documented admixture events. Using molecular data for this breed, we found that structure did not resolve very low (<5% levels) of introgression, possibly due to sampling limitations. We evaluated the performance of two ABC approaches (2BAD and DIYABC) against those of two earlier methodologies, ADMIX and LEADMIX, by comparing their interpretations with the conclusions drawn from herdbook analysis. The ABC methods gave credible values for the proportions of the Lincoln Red genotype that are attributable to Aberdeen Angus and Limousin, although estimates of effective population size and event timing were not realistic. We suggest ABC methods are a valuable supplement to pedigree-based studies but that the accuracy of admixture determination is likely to diminish with increasing complexity of the admixture scenario. © 2013 Blackwell Verlag GmbH.

Effectiveness of a 95 SNP panel for the screening of breed label fraud in the Chinese meat market.

PubMed

Rogberg-Muñoz, A; Wei, S; Ripoli, M V; Guo, B L; Carino, M H; Lirón, J P; Prando, A J; Vaca, R J A; Peral-García, P; Wei, Y M; Giovambattista, G

2016-01-01

Breed assignment has proved to be useful to control meat trade and protect the value of special productions. Meat-related frauds have been detected in China; therefore, 95 SNPs selected from the ISAG core panel were evaluated to develop an automated and technologically updated tool to screen breed label fraud in the Chinese meat market. A total of 271 animals from four Chinese yellow cattle (CYC) populations, six Bos taurus breeds, two Bos indicus and one composite were used. The allocation test distinguished European, Japanese and Zebu breeds, and two Chinese genetic components. It correctly allocated Japanese Black, Zebu and British breeds in 100, 90 and 89% of samples, respectively. CYC evidenced the Zebu, Holstein and Limousin introgression. The test did not detect CYC components in any of the 25 samples from Argentinean butchers. The method could be useful to certify Angus, Hereford and Japanese Black meat, but a modification in the panel would be needed to differentiate other breeds. Copyright © 2015 Elsevier Ltd. All rights reserved.

Genetic relationships between feral cattle from Chirikof Island, Alaska and other breeds.

PubMed

MacNeil, M D; Cronin, M A; Blackburn, H D; Richards, C M; Lockwood, D R; Alexander, L J

2007-06-01

The origin of cattle on Chirikof Island, off the coast of Alaska, is not well documented. We assessed genetic differentiation of cattle isolated on Chirikof Island from several breeds commonly used for commercial production in North America including breeds popularly believed to have contributed to the Chirikof Island population. A set of 34 microsatellite loci was used to genotype Angus, Charolais, Hereford, Highland, Limousin, Red Angus, Salers, Shorthorn, Simmental, Tarentaise and Texas Longhorn cattle sampled from North America and the Chirikof Island population. Resulting F(ST) statistics for these loci ranged from 0.06 to 0.22 and on average, 14% of total genetic variation was between breeds. Whether population structure was modelled as a bifurcating tree or genetic network, Chirikof Island cattle appeared to be unique and strongly differentiated relative to the other breeds that were sampled. Bayesian clustering for multiple-locus assignment to genetic groups indicated low levels of admixture in the Chirikof Island population. Thus, the Chirikof Island population may be a novel genetic resource of some importance for conservation and industry.

Effets de l'humidite sur la propagation du delaminage dans un composite carbone/epoxy sollicite en mode mixte I/II

NASA Astrophysics Data System (ADS)

LeBlanc, Luc R.

Les materiaux composites sont de plus en plus utilises dans des domaines tels que l'aerospatiale, les voitures a hautes performances et les equipements sportifs, pour en nommer quelques-uns. Des etudes ont demontre qu'une exposition a l'humidite nuit a la resistance des composites en favorisant l'initiation et la propagation du delaminage. De ces etudes, tres peu traitent de l'effet de l'humidite sur l'initiation du delaminage en mode mixte I/II et aucune ne traite des effets de l'humidite sur le taux de propagation du delaminage en mode mixte I/II dans un composite. La premiere partie de cette these consiste a determiner les effets de l'humidite sur la propagation du delaminage lors d'une sollicitation en mode mixte I/II. Des eprouvettes d'un composite unidirectionnel de carbone/epoxy (G40-800/5276-1) ont ete immergees dans un bain d'eau distillee a 70°C jusqu'a leur saturation. Des essais experimentaux quasi-statiques avec des chargements d'une gamme de mixites des modes I/II (0%, 25%, 50%, 75% et 100%) ont ete executes pour determiner les effets de l'humidite sur la resistance au delaminage du composite. Des essais de fatigue ont ete realises, avec la meme gamme de mixite des modes I/II, pour determiner 1'effet de 1'humidite sur l'initiation et sur le taux de propagation du delaminage. Les resultats des essais en chargement quasi-statique ont demontre que l'humidite reduit la resistance au delaminage d'un composite carbone/epoxy pour toute la gamme des mixites des modes I/II, sauf pour le mode I ou la resistance au delaminage augmente apres une exposition a l'humidite. Pour les chargements en fatigue, l'humidite a pour effet d'accelerer l'initiation du delaminage et d'augmenter le taux de propagation pour toutes les mixites des modes I/II. Les donnees experimentales recueillies ont ete utilisees pour determiner lesquels des criteres de delaminage en statique et des modeles de taux de propagation du delaminage en fatigue en mode mixte I/II proposes dans la litterature representent le mieux le delaminage du composite etudie. Une courbe de regression a ete utilisee pour determiner le meilleur ajustement entre les donnees experimentales et les criteres de delaminage en statique etudies. Une surface de regression a ete utilisee pour determiner le meilleur ajustement entre les donnees experimentales et les modeles de taux de propagation en fatigue etudies. D'apres les ajustements, le meilleur critere de delaminage en statique est le critere B-K et le meilleur modele de propagation en fatigue est le modele de Kenane-Benzeggagh. Afin de predire le delaminage lors de la conception de pieces complexes, des modeles numeriques peuvent etre utilises. La prediction de la longueur de delaminage lors des chargements en fatigue d'une piece est tres importante pour assurer qu'une fissure interlaminaire ne va pas croitre excessivement et causer la rupture de cette piece avant la fin de sa duree de vie de conception. Selon la tendance recente, ces modeles sont souvent bases sur l'approche de zone cohesive avec une formulation par elements finis. Au cours des travaux presentes dans cette these, le modele de progression du delaminage en fatigue de Landry & LaPlante (2012) a ete ameliore en y ajoutant le traitement des chargements en mode mixte I/II et en y modifiant l'algorithme du calcul de la force d'entrainement maximale du delaminage. Une calibration des parametres de zone cohesive a ete faite a partir des essais quasi-statiques experimentaux en mode I et II. Des resultats de simulations numeriques des essais quasi-statiques en mode mixte I/II, avec des eprouvettes seches et humides, ont ete compares avec les essais experimentaux. Des simulations numeriques en fatigue ont aussi ete faites et comparees avec les resultats experimentaux du taux de propagation du delaminage. Les resultats numeriques des essais quasi-statiques et de fatigue ont montre une bonne correlation avec les resultats experimentaux pour toute la gamme des mixites des modes I/II etudiee.

Mesure de haute resolution de la fonction de distribution radiale du silicium amorphe pur

NASA Astrophysics Data System (ADS)

Laaziri, Khalid

1999-11-01

Cette these porte sur l'etude de la structure du silicium amorphe prepare par irradiation ionique. Elle presente des mesures de diffraction de rayons X sur de la poudre de silicium cristallin, du silicium amorphe relaxe et non relaxe, ainsi que tous les developpements mathematiques et physiques necessaires pour extraire la fonction de distribution radiale correspondant a chaque echantillon. Au Chapitre I, nous presentons une methode de fabrication de membranes minces de silicium amorphe pur. Il y a deux etapes majeures lors du processus de fabrication: l'implantation ionique, afin de creer une couche amorphe de plusieurs microns et l'attaque chimique, pour enlever le reste du materiau cristallin. Nous avons caracterise premierement les membranes de silicium amorphe par spectroscopie Raman pour verifier qu'il ne reste plus de trace de materiau cristallin dans les films amorphes. Une deuxieme caracterisation par detection de recul elastique (ERD-TOF) sur ces memes membranes a montre qu'il y a moins de 0.1% atomique de contaminants tels que l'oxygene, le carbone, et l'hydrogene. Au Chapitre II, nous proposons une nouvelle methode de correction de la contribution inelastique "Compton" des spectres de diffusion totale afin d'extraire les pics de diffusion elastique, responsable de la diffraction de Bragg. L'article presente tout d'abord une description simplifiee d'une theorie sur la diffusion inelastique dite "Impulse Approximation" (IA) qui permet de calculer des profils de Compton en fonction de l'energie et de l'angle de diffusion 2theta. Ces profils sont utilises comme fonction de lissage de la diffusion Compton experimentale. Pour lisser les pics de diffusion elastique, nous avons utilise une fonction pic de nature asymetrique. Aux Chapitre III, nous exposons de maniere detaillee les resultats des experiences de diffraction de rayons X sur les membranes de silicium amorphe et la poudre de silicium cristallin que nous avons preparees. Nous abordons aussi les differentes etapes experimentales, d'analyse ainsi que les methodes de determination et de filtrage des transformees de Fourier des donnees de diffraction. Une comparaison des fonctions de distribution radiale du silicium amorphe relaxe et non relaxe indique que la relaxation structurelle dans le silicium amorphe est probablement due en grande partie a une annihilation des defauts plutot qu'a une reorganisation atomique globale du reseau de silicium amorphe. La deduction de la coordination des pics correspondants au premiers voisins atomiques par lissage de fonctions gaussienne indique que la coordination du silicium amorphe relaxe est de 3.88, celle du non-relaxe est de 3.79, alors que la mesure de reference sur la poudre de silicium cristallin donne une valeur de 4 tel que prevu. La sous-coordination du silicium amorphe expliquerait pourquoi sa densite est inferieure a celle du silicium cristallin. (Abstract shortened by UMI.)

Concentration and characteristics of depleted uranium in water, air and biological samples collected in Serbia and Montenegro.

PubMed

Jia, Guogang; Belli, Maria; Sansone, Umberto; Rosamilia, Silvia; Gaudino, Stefania

2005-09-01

During the Balkan conflicts, in 1995 and 1999, depleted uranium (DU) rounds were employed and were left in the battlefield. Health concern is related to the risk arising from contamination of the environment with DU penetrators and dust. In order to evaluate the impact of DU on the environment and population in Serbia and Montenegro, radiological surveys of DU in water, air and biological samples were carried out over the period 27 October-5 November 2001. The uranium isotopic concentrations in biological samples collected in Serbia and Montenegro, mainly lichens and barks, were found to be in the range of 0.67-704 Bqkg(-1) for (238)U, 0.48-93.9 Bqkg(-1) for (234)U and 0.02-12.2 Bqkg(-1) for (235)U, showing uranium levels to be higher than in the samples collected at the control sites. Moreover, (236)U was detectable in some of the samples. The isotopic ratios of (234)U/(238)U showed DU to be detectable in many biological samples at all examined sites, especially in Montenegro, indicating widespread ground-surface DU contamination, albeit at very low level. The uranium isotopic concentrations in air obtained from the air filter samples collected in Serbia and Montenegro were found to be in the range of 1.99-42.1 microBqm(-3) for (238)U, 0.96-38.0 microBqm(-3) for (234)U, and 0.05-1.83 microBqm(-3) for (235)U, being in the typical range of natural uranium values. Thus said, most of the air samples are DU positive, this fact agreeing well with the widespread DU contamination detected in the biological samples. The uranium concentrations in water samples collected in Serbia and Montenegro were found to be in the range of 0.40-21.9 mBql(-1) for (238)U, 0.27-28.1 mBql(-1) for (234)U, and 0.01-0.88 mBql(-1) for (235)U, these values being much lower than those in mineral water found in central Italy and below the WHO guideline for drinking water. From a radiotoxicological point of view, at this moment there is no significant radiological risk related to these investigated sites in terms of possible DU contamination of water, air and/or plants.

Epidémiologie et prise en charge des infections du per-partum à la maternité du centre hospitalier départemental de l'Ouémé-Plateau au Bénin

PubMed Central

Saizonou, Jacques; Ouédraogo, Laurent; Paraiso, Moussiliou Noël; Ayélo, Paul; Kpozèhouen, Alphonse; Daraté, René; Traoré, Esther

2014-01-01

Introduction La présente étude avait pour objectif de mesurer l'ampleur des infections du per-partum à la maternité du Centre Hospitalier Départemental de l'Ouémé-Plateau d'analyser les conditions de survenue et de prise en charge dans la perspective de l'amélioration des soins et services maternels et néonataux. Méthodes Une étude descriptive et analytique a été conduite de Août 2009 à Février 2010 et a impliqué 110 mères victimes d'infections du per-partum; elles ont été soumises à un questionnaire durant tout leur séjour hospitalier; des observations des pratiques de prise en charge des prestataires de soins ont été menées et des registres et autres supports de données sanitaires ont été exploités. L'analyse des données a été effectuée à l'aide du logiciel Epi Info 6.4 dans sa version française. Résultats L'incidence des infections du per-partum était de 5,9 pour 100 accouchements (110/ 1875); les types d'infections les plus incriminés étaient les endométrites (27,3%), les chorioamniotites (18,2%), les infections du site opératoire (12,7%) et les infections urinaires (2,7%). Les examens cliniques ont été relativement acceptables. En revanche, les examens biologiques ont été très insuffisants expliquant l'imprécision importante au niveau des diagnostics. L'antibiothérapie a été instaurée systématiquement. Le taux de mortinaissance était de 25,6% et les enfants de petit poids représentaient 23,2%. Conclusion L'incidence des infections du per-partum dans la présente étude était assez élevée. Des efforts de préventions et de dépistage de ces infections sont nécessaire afin d'améliorer la qualité des soins PMID:25120854

Particularités de la cardiomyopathie du péripartum en Afrique: le cas du Togo sur une étude prospective de 41 cas au Centre Hospitalier et Universitaire Sylvanus Olympio de Lomé

PubMed Central

Pio, Machihude; Afassinou, Yaovi; Baragou, Soodougoua; Akue, Edem Goeh; Péssinaba, Souleymane; Atta, Borgatia; Ehlan, Koffi; Alate, Amouzou; Damorou, Findibe

2014-01-01

Introduction La cardiomyopathie du péripartum (CMPP) est une défaillance cardiaque dont l’étiologie demeure encore méconnue. Méthodes Il s'agit d'une étude prospective descriptive réalisée dans le service de cardiologie du CHU Sylvanus olympio de Lomé du 1er janvier 2010 au 30 avril 2012. Elle a concerné 41 patientes ayant présenté une insuffisance cardiaque entre le 8eme mois de la grossesse et les 5 premiers mois du post-partum. Résultats L’âge moyen des patientes était de 31,47 ans (extrêmes 21 et 44ans). L'incidence de la CMPP était de 1/362 grossesses. La parité moyenne était de 3,07 (extrêmes 1 et 6). Les symptômes étaient apparus dans le post-partum dans 90,24% des cas. Un retard important de diagnostic était observé. L'insuffisance cardiaque globale était le mode de décompensation dans 65,85%. Les signes électrocardiographiques étaient essentiellement la tachycardie sinusale (97,56%) et l'hypertrophie ventriculaire gauche (97,56%). L’échographie cardiaque a montré dans tous les cas une cardiomyopathie dilatée. Quatre cas de thrombus intraventriculaire gauche étaient notés. La FEVG était sévèrement altérée. L'HTAP était importante dans 56,09%. Conclusion La cardiomyopathie du péripartum est une complication cardiaque grave de la grossesse de cause inconnue, fréquente dans la population africaine. PMID:25309645

Incorporation of a cationic aminopropyl chain in DNA hairpins: thermodynamics and hydration

PubMed Central

Soto, Ana Maria; Kankia, Besik I.; Dande, Prasad; Gold, Barry; Marky, Luis A.

2001-01-01

We report on the physicochemical effects resulting from incorporating a 5-(3-aminopropyl) side chain onto a 2′-deoxyuridine (dU) residue in a short DNA hairpin. A combination of spectroscopy, calorimetry, density and ultrasound techniques were used to investigate both the helix–coil transition of a set of  hairpins with the following sequence: d(GCGACTTTTTGNCGC) [N = dU, deoxythymidine (dT) or 5-(3-aminopropyl)-2′-deoxyuridine (dU*)], and the interaction of each hairpin with Mg2+. All three molecules undergo two-state transitions with melting temperatures (TM) independent of strand concentration that indicates their intramolecular hairpin formation. The unfolding of each hairpin takes place with similar TM values of 64–66°C and similar thermodynamic profiles. The unfavorable unfolding free energies of 6.4–6.9 kcal/mol result from the typical compensation of unfavorable enthalpies, 36–39 kcal/mol, and favorable entropies of ∼110 cal/mol. Furthermore, the stability of each hairpin increases as the salt concentration increases, the TM-dependence on salt yielded slopes of 2.3–2.9°C, which correspond to counterion releases of 0.53 (dU and dT) and 0.44 (dU*) moles of Na+ per mole of hairpin. Absolute volumetric and compressibility measurements reveal that all three hairpins have similar hydration levels. The electrostatic interaction of Mg2+ with each hairpin yielded binding affinities in the order: dU > dT > dU*, and a similar release of 2–4 electrostricted water molecules. The main result is that the incorporation of the cationic 3-aminopropyl side chain in the major groove of the hairpin stem neutralizes some local negative charges yielding a hairpin molecule with lower charge density. PMID:11522834

Annealing of (DU-10Mo)-Zr Co-Rolled Foils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pacheco, Robin Montoya; Alexander, David John; Mccabe, Rodney James

2017-01-20

Producing uranium-10wt% molybdenum (DU-10Mo) foils to clad with Al first requires initial bonding of the DU-10Mo foil to zirconium (Zr) by hot rolling, followed by cold rolling to final thickness. Rolling often produces wavy (DU-10Mo)-Zr foils that should be flattened before further processing, as any distortions could affect the final alignment and bonding of the Al cladding to the Zr co-rolled surface layer; this bonding is achieved by a hot isostatic pressing (HIP) process. Distortions in the (DU-10Mo)-Zr foil may cause the fuel foil to press against the Al cladding and thus create thinner or thicker areas in the Almore » cladding layer during the HIP cycle. Post machining is difficult and risky at this stage in the process since there is a chance of hitting the DU-10Mo. Therefore, it is very important to establish a process to flatten and remove any waviness. This study was conducted to determine if a simple annealing treatment could flatten wavy foils. Using the same starting material (i.e. DU-10Mo coupons of the same thickness), five different levels of hot rolling and cold rolling, combined with five different annealing treatments, were performed to determine the effect of these processing variables on flatness, bonding of layers, annealing response, microstructure, and hardness. The same final thickness was reached in all cases. Micrographs, textures, and hardness measurements were obtained for the various processing combinations. Based on these results, it was concluded that annealing at 650°C or higher is an effective treatment to appreciably reduce foil waviness.« less

Combined effects of alpha particles and depleted uranium on Zebrafish (Danio rerio) embryos

PubMed Central

Ng, Candy Y.P.; Pereira, Sandrine; Cheng, Shuk Han; Adam-Guillermin, Christelle; Garnier-Laplace, Jacqueline; Yu, Kwan Ngok

2016-01-01

The combined effects of low-dose or high-dose alpha particles and depleted uranium (DU) in Zebrafish (Danio rerio) embryos were studied. Three schemes were examined—(i) [ILUL]: 0.44 mGy alpha-particle dose + 10 µg/l DU exposure, (ii) [IHUH]: 4.4 mGy alpha-particle dose + 100 µg/l DU exposure and (iii) [IHUL]: 4.4 mGy alpha-particle dose + 10 µg/l DU exposure—in which Zebrafish embryos were irradiated with alpha particles at 5 h post fertilization (hpf) and/or exposed to uranium at 5–6 hpf. The results were also compared with our previous work, which studied the effects of [ILUH]: 0.44 mGy alpha-particle dose + 100 µg/l DU exposure. When the Zebrafish embryos developed to 24 hpf, the apoptotic signals in the entire embryos, used as the biological endpoint for this study, were quantified. Our results showed that [ILUL] and [IHUL] led to antagonistic effects, whereas [IHUH] led to an additive effect. The effect found for the previously studied case of [ILUH] was difficult to define because it was synergistic with reference to the 100 µg/l DU exposure, but it was antagonistic with reference to the 0.44 mGy alpha-particle dose. All the findings regarding the four different schemes showed that the combined effects critically depended on the dose response to each individual stressor. We also qualitatively explained these findings in terms of promotion of early death of cells predisposed to spontaneous transformation by alpha particles, interacting with the delay in cell death resulting from various concentrations of DU exposure. PMID:26937024

Effet paradoxal du type d’excision sur la prise et le délai de cicatrisation des greffes expansées pour le traitement des brûlures aiguës: a propos de 1129 cas

PubMed Central

Guibert, M.; Chaouat, M.; Boccara, D.; Marco, O.; Lavocat, R.; Alameri, O.; Deslandes, E.; Montlahuc, C.; Mimoun, M.

2016-01-01

Summary La greffe de peau mince expansée est très employée dans le traitement des brûlures aiguës. Nous avons étudié l’influence de la préparation du sous-sol sur le taux de prise et le délai de cicatrisation des greffes expansées. Nous avons analysé rétrospectivement les 1 129 greffes expansées réalisées dans notre service entre 1995 et 2005 pour le traitement des brûlures aiguës. Leur taux de prise a été significativement meilleur après une préparation du sous-sol par avulsion (82%) par rapport à une préparation du sous-sol par excision tangentielle (75%). Ce taux était meilleur lorsque l’avulsion était pratiquée dans les 7 jours suivant la brûlure (83% vs 73%). Pour une prise en charge entre 7 et 21 jours, ce taux a semblé être meilleur après excision tangentielle, mais de façon non significative. La durée d’évolution jusqu’à cicatrisation était significativement raccourcie pour une préparation du sous-sol par excision tangentielle par rapport à une préparation du sous-sol par avulsion. Ces résultats montrent, paradoxalement, qu’une préparation du sous-sol par avulsion favorise la prise des greffes expansées mais rallonge leur délai de cicatrisation au contraire de l’excision tangentielle. PMID:28149235

Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: role of reactive oxygen species, GSH and Nrf2 in radiosensitivity.

PubMed

Jayakumar, Sundarraj; Kunwar, Amit; Sandur, Santosh K; Pandey, Badri N; Chaubey, Ramesh C

2014-01-01

Radioresistance is the major impediment in radiotherapy of many cancers including prostate cancer, necessitating the need to understand the factors contributing to radioresistance in tumor cells. In the present study, the role of cellular redox and redox sensitive transcription factor, Nrf2 in the radiosensitivity of prostate cancer cell lines PC3 and DU145, has been investigated. Differential radiosensitivity of PC3 and DU145 cells was assessed using clonogenic assay, flow cytometry, and comet assay. Their redox status was measured using DCFDA and DHR probes. Expression of Nrf2 and its dependent genes was measured by EMSA and real time PCR. Knockdown studies were done using shRNA transfection. PC3 and DU145 cells differed significantly in their radiosensitivity as observed by clonogenic survival, apoptosis and neutral comet assays. Both basal and inducible levels of ROS were higher in PC3 cells than that of DU145 cells. DU145 cells showed higher level of basal GSH content and GSH/GSSG ratio than that of PC3 cells. Further, significant increase in both basal and induced levels of Nrf2 and its dependent genes was observed in DU145 cells. Knock-down experiments and pharmacological intervention studies revealed the involvement of Nrf2 in differential radio-resistance of these cells. Cellular redox status and Nrf2 levels play a causal role in radio-resistance of prostate cancer cells. The pivotal role Nrf2 has been shown in the radioresistance of tumor cells and this study will further help in exploiting this factor in radiosensitization of other tumor cell types. © 2013.

The Pekin duck programmed death-ligand 1: cDNA cloning, genomic structure, molecular characterization and mRNA expression analysis.

PubMed

Yao, Q; Fischer, K P; Tyrrell, D L; Gutfreund, K S

2015-04-01

Programmed death ligand-1 (PD-L1) plays an important role in the attenuation of adaptive immune responses in higher vertebrates. Here, we describe the identification of the Pekin duck PD-L1 orthologue (duPD-L1) and its gene structure. The duPD-L1 cDNA encodes a 311-amino acid protein that has an amino acid identity of 78% and 42% with chicken and human PD-L1, respectively. Mapping of the duPD-L1 cDNA with duck genomic sequences revealed an exonic structure of its coding sequence similar to those of other vertebrates but lacked a noncoding exon 1. Homology modelling of the duPD-L1 extracellular domain was compatible with the tandem IgV-like and IgC-like IgSF domain structure of human PD-L1 (PDB ID: 3BIS). Residues known to be important for receptor binding of human PD-L1 were mostly conserved in duPD-L1 within the N-terminus and the G sheet, and partially conserved within the F sheet but not within sheets C and C'. DuPD-L1 mRNA was constitutively expressed in all tissues examined with highest expression levels in lung and spleen and very low levels of expression in muscle, kidney and brain. Mitogen stimulation of duck peripheral blood mononuclear cells transiently increased duPD-L1 mRNA expression. Our observations demonstrate evolutionary conservation of the exonic structure of its coding sequence, the extracellular domain structure and residues implicated in receptor binding, but the role of the longer cytoplasmic tail in avian PD-L1 proteins remains to be determined. © 2014 John Wiley & Sons Ltd.

Littoral Infrared Ship Self Defence Technology Studies (Autodefense cotiere infrarouge des navires etudes technologiques)

DTIC Science & Technology

2014-05-01

de simulation du Simulateur de Contre- mesures de la Menace Navale afin de pouvoir inclure des leurres et des autodirecteurs de missiles ; 4) Une...sur le littoral ; 2) La détection des petites cibles de surface sur le littoral ; 3) L’amélioration et la validation de la modélisation et du code...amélioration et une validation supplémentaire de la modélisation et du

Use of Scientific and Technical Information in the NATO Countries

DTIC Science & Technology

1983-03-01

pouvoirs publics resultant de la coordination de 1’information dans les secteurs Defense et ASrospatlal sont pr^sent^s a travers 1’organisation du...et le secteur Aerospatial s’lmpose pour des raisons d’efficacit^ et d’Sconomie de moyens. Cette coordination devra cependant tenir compte de la sp...cificit§ des problemes de Defense et de 1’importance militaire et industrlelle du secteur aerospatial qui provient essentiellement : . du caractere

40 CFR 82.5 - Apportionment of baseline production allowances for class I controlled substances.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 23,082,358 E.I. DuPont de Nemours & Co 33,830,000 Elf Atochem, N.A 21,821,500 CFC-12 Laroche Chemicals 12,856,364 Allied-Signal, Inc 35,699,776 E.I. DuPont de Nemours & Co 64,849,000 Elf Atochem, N.A 31,089,807 CFC-113 Laroche Chemicals 15,330,909 Allied-Signal, Inc 21,788,896 CFC-114 E.I. DuPont de...

40 CFR 82.5 - Apportionment of baseline production allowances for class I controlled substances.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 23,082,358 E.I. DuPont de Nemours & Co 33,830,000 Elf Atochem, N.A 21,821,500 CFC-12 Laroche Chemicals 12,856,364 Allied-Signal, Inc 35,699,776 E.I. DuPont de Nemours & Co 64,849,000 Elf Atochem, N.A 31,089,807 CFC-113 Laroche Chemicals 15,330,909 Allied-Signal, Inc 21,788,896 CFC-114 E.I. DuPont de...

Africa Civic Action Planning and Implementation Guide

DTIC Science & Technology

1988-03-17

transfert du titre de propriet4 ou. que les d~fectuosit~s provenant de la conception sont... transfert du * .~.titre prendra effet normalement. au point de chargement chez le * fabricant; et pour ].es articles de de’fense fournis sur les stocks...dition avant l~e transfert . du Ititre de proprie’t4. Si l~e "lieu de livraison" d~sign4 est autre que le point initial d’expe’d’tion, l~e

Le syndrome de Pepper: à propos de deux cas observés au Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou (Burkina Faso)

PubMed Central

Kam, Madibèlè; Douamba, Sonia; Nagalo, Kisito; Dao, Lassina; Kouéta, Fla; Lougué, Claudine; Yé, Diarra

2017-01-01

Le syndrome de Pepper est une forme métastatique hépatique du neuroblastome. C’est une entité spécifique du nourrisson de moins de six mois qui a la particularité de pouvoir régresser de façon spontanée avec un pronostic favorable dans 80% des cas. A cause de sa rareté, nous rapportons deux cas du syndrome de Pepper observés au Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle de Ouagadougou (Burkina Faso). Il s’agissait de deux nourrissons de sexe féminin chez qui la symptomatologie de la maladie se traduisait par une augmentation du volume abdominal, une hépatomégalie et des signes de lutte respiratoire. L'échographie a permis de poser le diagnostic par l’aspect nodulaire du foie dans les deux cas et la détermination de la tumeur primitive dans un cas. Le dosage des catécholamines urinaires a confirmé un cas. L’évolution était fatale chez les deux patientes du fait des complications de compression par le foie, des complications de la chimiothérapie dans l’un des cas et l’absence de traitement dans l’autre cas. PMID:29599887

Synthesis and In Vitro Evaluation of 5-[18F]Fluoroalkyl Pyrimidine Nucleosides for Molecular Imaging of Herpes Simplex Virus Type-1 Thymidine Kinase Reporter Gene Expression

PubMed Central

Chacko, Ann-Marie; Qu, Wenchao; Kung, Hank F.

2014-01-01

Two novel series of 5-fluoroalkyl-2′-deoxyuridines (FPrDU, FBuDU, FPeDU) and 2′-fluoro-2′-deoxy-5-fluoroalkylarabinouridines (FFPrAU, FFBuAU, FFPeAU), having three, four or five methylene units (propyl, butyl, or pentyl) at C-5, were prepared and tested as reporter probes for imaging HSV1-tk gene expression. The Negishi coupling methodology was employed to efficiently synthesize the radiolabeling precursors. All six 5-[18F]fluoroalkyl pyrimidines were prepared readily from 3-N-benzoyl-3′,5′-di-O-benzoyl-protected 5-O-mesylate precursors in 17–35% radiochemical yield (decay-corrected). In vitro studies highlighted that all six [18F]labeled nucleosides selectively accumulated in cells expressing the HSV1-TK protein, with negligible uptake in control cells. [18F]FPrDU, [18F]FBuDU, [18F]FPeDU, and [18F]FFBuAU had the best uptake profiles. Despite selective accumulation in HSV1-tk expressing cells, all 5-fluoroalkyl pyrimidine nucleosides had low to negligible cytotoxic activity (CC50>1000–209 μM). Ultimately, results demonstrated that 5-[18F]fluoropropyl, [18F]fluorobutyl, and [18F]fluoropentyl pyrimidine nucleosides have potential as in vivo HSV1-TK PET reporter probes over a dynamic range of reporter gene expression levels. PMID:18800764

Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat.

PubMed

Racine, R; Grandcolas, L; Grison, S; Stefani, J; Delissen, O; Gourmelon, P; Veyssière, G; Souidi, M

2010-05-01

Depleted uranium (DU) is a radioactive heavy metal derived from the nuclear energy production. Its wide use in civilian and military items increases the risk of its environmental dissemination, and thus the risk of internal contamination of populations living in such contaminated territories. Previous studies have shown that vitamin D and cerebral cholesterol metabolisms were affected following chronic ingestion of DU. Even more than the brain, the liver is a crucial organ in cholesterol homeostasis since it regulates cholesterol distribution and elimination at body level. The aim of this work was to assess the impact of a low-level chronic ingestion of DU on hepatic cholesterol metabolism. Rats were contaminated with DU in their drinking water at a concentration of 40mg/l for 9 months. The major effect induced by DU was a decrease of CYP7A1 specific activity (-60%) correlated with a matching decrease of its product 7alpha-hydroxycholesterol in the plasma. Hepatic gene expression of transporters ABC A1, ABC G5, ABC G8 and of nuclear receptor RXR was increased, whereas that of catabolism enzyme CYP7B1 was decreased. Thus, after a chronic ingestion of DU, rats experience a modulation of cholesterol catabolism but overcome it, since their cholesterolemia is preserved and no pathology is declared.

Evaluation of depleted uranium in the environment at Aberdeen Proving Grounds, Maryland and Yuma Proving Grounds, Arizona. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kennedy, P.L.; Clements, W.H.; Myers, O.B.

1995-01-01

This report represents an evaluation of depleted uranium (DU) introduced into the environment at the Aberdeen Proving Grounds (APG), Maryland and Yuma Proving Grounds (YPG) Arizona. This was a cooperative project between the Environmental Sciences and Statistical Analyses Groups at LANL and with the Department of Fishery and Wildlife Biology at Colorado State University. The project represents a unique approach to assessing the environmental impact of DU in two dissimilar ecosystems. Ecological exposure models were created for each ecosystem and sensitivity/uncertainty analyses were conducted to identify exposure pathways which were most influential in the fate and transport of DU inmore » the environment. Research included field sampling, field exposure experiment, and laboratory experiments. The first section addresses DU at the APG site. Chapter topics include bioenergetics-based food web model; field exposure experiments; bioconcentration by phytoplankton and the toxicity of U to zooplankton; physical processes governing the desorption of uranium from sediment to water; transfer of uranium from sediment to benthic invertebrates; spead of adsorpion by benthic invertebrates; uptake of uranium by fish. The final section of the report addresses DU at the YPG site. Chapters include the following information: Du transport processes and pathway model; field studies of performance of exposure model; uptake and elimination rates for kangaroo rates; chemical toxicity in kangaroo rat kidneys.« less

Quand le malheur frappe les bénéficiaires de la sécurité du revenu. Sur qui peuvent-ils s’appuyer ?

PubMed Central

Tousignant, Michel; Caron, Jean

2013-01-01

Cette étude analyse les conditions de réalisation du soutien social dans les quartiers de Saint-Henri et de la Pointe Saint-Charles, en comparant un groupe de 61 prestataires de la sécurité du revenu avec un échantillon de 21 personnes de la population vivant au-dessus du seuil de la pauvreté, et en fonction du degré de détresse dans chaque groupe. Elle vise également à décrire comment une adversité vécue par les prestataires avec ou sans détresse vient briser ou modifier le réseau de soutien. Les résultats indiquent que le réseau social est moins fiable en présence de détresse qu’en son absence, que les personnes en détresse se sont vues plus fréquemment refuser du soutien ou être abandonnées et qu’elles ont davantage de personnes nuisibles dans leur entourage. De plus, les événements vécus comportent souvent une atteinte à leur réputation, des menaces, des trahisons et des refus à un droit légitime. Les personnes en détresse sont aussi davantage isolées. PMID:16505926

Émilie Du Châtelet's interpretation of the laws of motion in the light of 18th century mechanics.

PubMed

Reichenberger, Andrea

2018-06-01

Émilie Du Châtelet is well known for her French translation of Newton's Philosophiae Naturalis Principia Mathematica. It is the first and only French translation of Newton's magnum opus. The complete work appeared in 1759 under the title Principes mathématiques de la philosophie naturelle, par feue Madame la Marquise Du Chastellet. Before translating Newton's Principia, Du Châtelet worked on her Institutions de physique. In this book she defended the Leibnizian concept of living forces - vis viva. This paper argues that both of these works were part of a critical transformation and consolidation of post-Newtonian mechanics in the early 18th century, beyond Newton and Leibniz. This will be shown by comparing Du Châtelet's translation of Newton's axioms with her own formulations of the laws of motion in light of Thomas Le Seur's and François Jacquier's Geneva edition which holds a special place among the several editions of the Principia that appeared in the early 18th century. Copyright © 2018 Elsevier Ltd. All rights reserved.

Rapport sur l'état du patrimoine astronomique dans les observatoires français de la fin du XIXè siècle

NASA Astrophysics Data System (ADS)

Damm, E.; Pécontal, E.

2012-12-01

Suite au colloque sur la sauvegarde du patrimoine astronomique organisé par le MAEE et la SAF, sous l'égide de l'UNESCO, qui a conduit à l'adoption de la Déclaration de Paris, les directeurs d'observatoires institutionnels qui étaient absents du colloque ont ressenti le besoin de discuter de ces conclusions prises en leur nom. L'initiative d'organiser une réunion des directeurs des Observatoires des Sciences de l'Univers (OSU) à ce sujet le 30 janvier 2012 a été prise par François Vernotte, directeur de l'Observatoire de Besançon. Le présent compte-rendu de visite résulte d'une initiative spontanée d'Emmanuel Pécontal, astronome responsable du Patrimoine à l'observatoire de Lyon, et d'Evelyne Damm, membre de la Commission Nationale de classement des Monuments Historiques (CNMH) et élue à la communauté d'agglomération des Portes de l'Essonne oû est sis l'observatoire de Camille Flammarion.

Des proprietes de l'etat normal du modele de Hubbard bidimensionnel

NASA Astrophysics Data System (ADS)

Lemay, Francois

Depuis leur decouverte, les etudes experimentales ont demontre que les supra-conducteurs a haute temperature ont une phase normale tres etrange. Les proprietes de ces materiaux ne sont pas bien decrites par la theorie du liquide de Fermi. Le modele de Hubbard bidimensionnel, bien qu'il ne soit pas encore resolu, est toujours considere comme un candidat pour expliquer la physique de ces composes. Dans cet ouvrage, nous mettons en evidence plusieurs proprietes electroniques du modele qui sont incompatibles avec l'existence de quasi-particules. Nous montrons notamment que la susceptibilite des electrons libres sur reseau contient des singularites logarithmiques qui influencent de facon determinante les proprietes de la self-energie a basse frequence. Ces singularites sont responsables de la destruction des quasi-particules. En l'absence de fluctuations antiferromagnetiques, elles sont aussi responsables de l'existence d'un petit pseudogap dans le poids spectral au niveau de Fermi. Les proprietes du modele sont egalement etudiees pour une surface de Fermi similaire a celle des supraconducteurs a haute temperature. Un parallele est etabli entre certaines caracteristiques du modele et celles de ces materiaux.