Sample records for uranium 224

  1. 25 CFR 224.30 - What definitions apply to this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... both renewable and nonrenewable energy sources, including, but not limited to, natural gas, oil, uranium, coal, nuclear, wind, solar, geothermal, biomass, and hydrologic resources. Imminent jeopardy to a...

  2. Radium isotope quartet in groundwater as a proxy for identification of aquifer rocks and mechanisms of water-rock interactions: examples from the Negev, Israel

    NASA Astrophysics Data System (ADS)

    Vengosh, A.; Pery, N.; Paytan, A.; Haquin, G.; Elhanani, S.; Pankratov, I.

    2006-05-01

    Many aquifer systems are composed of multiple rock types. Previous attempts to evaluate the specific aquifer rocks that control the groundwater chemistry and possible flow paths within these multiple lithological systems have used major ion chemistry and isotopic tracers (e.g., strontium isotopes). Here we propose an additional isotopic proxy that is based on the distribution of radium isotopes in groundwater. Radium has four radioactive isotopes that are part of the decay chains of uranium-238, thorium-232, and uranium-235. The abundance of radium isotope quartet (226Ra-half life 1600 y; 228Ra-5.6 y; 224Ra-3.6 d; 223Ra-11.4 d) in groundwater reflects the Th/U ratios in the rocks. Investigation of groundwater from the Negev, Israel, enabled us to discriminate between groundwaters flowing in the Lower Cretaceous Nubian Sandstone and the Upper Cretaceous Judea Group carbonate aquifers. Groundwater flowing in the sandstone aquifer has distinguishably high 228Ra/226Ra and 224Ra/223Ra ratios due to the high Th/U ratio in sandstone. In contrast, the predominance of uranium in carbonate rocks results in low 228Ra/226Ra and 224Ra/223Ra ratios in the associated groundwater. We show that the radium activity in groundwater in the two-aquifer systems is correlated with temperature, dissolved oxygen, and salinity. The increase of radium activity is also associated with changes in the isotopic ratios; 228Ra/226Ra ratios increase and decrease in the sandstone and carbonate aquifers, respectively. Given that the dissolution of radium isotopes depends on their decay constants, the use of the four radium isotopes with different decay constants enabled us to distinguish between dissolution (higher abundance of the long-lived isotopes) and recoil (predominance of the short-lived isotopes) processes. In spite of these isotopic fractionations, the radium isotopic discrimination between carbonate and sandstone aquifers is significant.

  3. What are the health costs of uranium mining? A case study of miners in Grants, New Mexico

    PubMed Central

    Jones, Benjamin A

    2014-01-01

    Background: Uranium mining is associated with lung cancer and other health problems among miners. Health impacts are related with miner exposure to radon gas progeny. Objectives: This study estimates the health costs of excess lung cancer mortality among uranium miners in the largest uranium-producing district in the USA, centered in Grants, New Mexico. Methods: Lung cancer mortality rates on miners were used to estimate excess mortality and years of life lost (YLL) among the miner population in Grants from 1955 to 2005. A cost analysis was performed to estimate direct (medical) and indirect (premature mortality) health costs. Results: Total health costs ranged from $2.2 million to $7.7 million per excess death. This amounts to between $22.4 million and $165.8 million in annual health costs over the 1955–1990 mining period. Annual exposure-related lung cancer mortality was estimated at 2185.4 miners per 100 000, with a range of 1419.8–2974.3 per 100 000. Conclusions: Given renewed interest in uranium worldwide, results suggest a re-evaluation of radon exposure standards and inclusion of miner long-term health into mining planning decisions. PMID:25224806

  4. Assessment of bacterial community composition in response to uranium levels in sediment samples of sacred Cauvery River.

    PubMed

    Suriya, Jayaraman; Chandra Shekar, Mootapally; Nathani, Neelam Mustakali; Suganya, Thangaiyan; Bharathiraja, Subramanian; Krishnan, Muthukalingan

    2017-01-01

    Global industrialization is a major cause of effluent discharge from industries up to alarming concentrations. Especially, uranium concentrations in water bodies are of great concern, as its radioactivity significantly affects the persistent diversity of microbiota. Recently, continuous application of pesticides in the agricultural lands and accumulation of quartz that enter the Cauvery River has significantly increased the concentration of uranium (U) and other heavy metals. To perceive the impact of uranium on bacterial diversity in Cauvery River, sediment samples collected from polluted (UP) site with 32.4 Bq/K of U concentration and control (UNP) site were scrutinized for bacterial diversity through metagenomic analysis of the V3 region of 16S rDNA by Illumina sequencing. Taxonomic assignment revealed that the unpolluted sample was dominated by Bacteroidetes (27.7 %), and Firmicutes (25.9 %), while sediment sample from the highly polluted site revealed abundance of Proteobacteria (47.5 %) followed by Bacteroidetes (22.4 %) and Firmicutes (14.6 %). Among Proteobacteria, Gammaproteobacteria was the most prevalent group followed by alpha, delta, epsilon, and beta in the uranium-polluted sample. Rare and abundant species analysis revealed that species like Idiomarina loihiensis was abundant in the pollutant sample; however, it was rare (<0.1 %) in the sample from pristine environment. Similarly, the species distribution in both the samples varied, with the bacteria potentially active in redox activity and biosorption potential dominating in the polluted sample. Outcomes of the present study demonstrated the impact of uranium and metal accumulation on the bacterial communities and further confirmed the promising candidature of specific bacterial species as bioindicators of contamination.

  5. A novel benzimidazole-functionalized 2-D COF material: synthesis and application as a selective solid-phase extractant for separation of uranium.

    PubMed

    Li, Juan; Yang, Xiaodan; Bai, Chiyao; Tian, Yin; Li, Bo; Zhang, Shuang; Yang, Xiaoyu; Ding, Songdong; Xia, Chuanqin; Tan, Xinyu; Ma, Lijian; Li, Shoujian

    2015-01-01

    A novel COF-based material (COF-COOH) containing large amounts of carboxylic groups was prepared for the first time by using a simple and effective one-step synthetic method, in which the cheap and commercially available raw materials, trimesoyl chloride and p-phenylenediamine, were used. The as-synthesized COF-COOH was modified with previously synthesized 2-(2,4-dihydroxyphenyl)-benzimidazole (HBI) by "grafting to" method, and a new solid-phase extractant (COF-HBI) with highly efficient sorption performance for uranium(VI) was consequently obtained. A series of characterizations demonstrated that COF-COOH and COF-HBI exhibited great thermostabilities and irradiation stabilities. Sorption behavior of the COF-based materials toward U(VI) was compared in simulated nuclear industrial effluent containing UO2(2+) and 11 undesired ions, and the UO2(2+) sorption amount of COF-HBI was 81 mg g(-1), accounting for approximately 58% of the total sorption amount, which was much higher than the sorption selectivity of COF-COOH to UO2(2+) (39%). Batch sorption experiment results indicated that the uranium(VI) sorption on COF-HBI was a pH dependent, rapid (sorption equilibrium was reached in 30 min), endothermic and spontaneous process. In the most favorable conditions, the equilibrium sorption capacity of the adsorbent for uranium could reach 211 mg g(-1). Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Investigation of the /sup 234/U//sup 238/U disequilibrium in the natural waters of the Santa Fe River basin north-central Florida

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Briel, L.I.

    1976-01-01

    Typical surface water masses in the Santa Fe basin are characterized by a /sup 238/U concentration of 0.224 +- .014 ppB and a /sup 234/U//sup 238/U activity ratio of 1.081 +- .038. The Floridan aquifer in this area is represented by at least two distinct regimes of ground water. The effluent from the Poe Springs group has a nominal uranium concentration of 0.938 +- .014 ppB and an activity ratio of 0.900 +- .012, while the effluent from the Ichetucknee Springs group has a nominal uranium concentration of 0.558 +- .018 ppB and an activity ratio of 0.707 +- .022.more » The effluent from ten additional springs in the Santa Fe system can be represented by hypothetical mixtures of these two ground water regimes and a hypothetical surface water component, which may reflect the extent of local recharge to the aquifer in different parts of the basin.« less

  7. Occurrence of Radium-224, Radium-226 and Radium-228 in Water from the Vincentown and Wenonah-Mount Laurel Aquifers, the Englishtown Aquifer System, and the Hornerstown and Red Bank Sands, Southwestern and South-Central New Jersey

    USGS Publications Warehouse

    dePaul, Vincent T.; Szabo, Zoltan

    2007-01-01

    This investigation is the first regionally focused study of the presence of natural radioactivity in water from the Vincentown and Wenonah-Mount Laurel aquifers, Englishtown aquifer system, and the Hornerstown and Red Bank Sands. Geologic materials composing the Vincentown and Wenonah-Mount Laurel aquifers and the Hornerstown and Red Bank Sands previously have been reported to contain radioactive (uranium-enriched) phosphatic strata, which is common in deposits from some moderate-depth coastal marine environments. The decay of uranium and thorium gives rise to natural radioactivity and numerous radioactive progeny, including isotopes of radium. Naturally occurring radioactive isotopes, especially those of radium, are of concern because radium is a known human carcinogen and ingestion (especially in water used for drinking) can present appreciable health risks. A regional network in southwestern and south-central New Jersey of 39 wells completed in the Vincentown and Wenonah-Mount Laurel aquifers, the Englishtown aquifer system, and the Hornerstown and Red Bank Sands was sampled for determination of gross alpha-particle activity; concentrations of radium radionuclides, major ions, and selected trace elements; and physical properties. Concentrations of radium-224, radium-226, and radium-228 were determined for water from 28 of the 39 wells, whereas gross alpha-particle activity was determined for all 39. The alpha spectroscopic technique was used to determine concentrations of radium-224, which ranged from less than 0.5 to 2.7 pCi/L with a median concentration of less than 0.5pCi/L, and of radium-226, which ranged from less than 0.5 to 3.2 pCi/L with a median concentration of less than 0.5 pCi/L. The beta-counting technique was used to determine concentrations of radium-228. The concentration of radium-228 ranged from less than 0.5 to 4.3 pCi/L with a median of less than 0.5. Radium-228, when quantifiable, had the greatest concentration of the three radium radioisotopes in 9 of the 12 samples (75 percent). The concentration of radium-224 exceeded that of radium-226 in five of the six (83 percent) samples when both were quantifiable. The radium concentration distribution differed by aquifer, with the highest Ra-228 concentrations present in the Englishtown aquifer system and the highest Ra-226 concentrations present in the Wenonah-Mount Laurel aquifer. Radium-224 generally contributed a considerable amount of gross alpha-particle activity to water produced from all the sampled aquifers, but was not the dominant radionuclide as it is in water from the Kirkwood-Cohansey aquifer system, nor were concentrations greater than 1 pCi/L of radium-224 widespread. Gross alpha-particle activity was found to exceed the U.S Environmental Protection Agency (USEPA) Maximum Contaminant Level (MCL) of 15 pCi/L in one sample (16 pCi/L) from the Vincentown aquifer. A greater part of the gross alpha-particle activity in water from the Wenonah-Mount Laurel aquifer resulted from the decay of Ra-226 than did the gross alpha-particle activity in the other sampled aquifers; this relation is consistent with the concentration distribution of the Ra-226 itself. Concentrations of radium-224 correlate strongly with those of both radium-226 and radium-228 (Spearman correlation coefficients, r, +0.86 and +0.66, respectively). The greatest concentrations of radium-224, radium-226, and radium-228 were present in the most acidic ground water. All radium-224, radium-226, and radium-228 concentrations greater than 2.5 pCi/L were present in ground-water samples with a pH less than 5.0. The presence of combined radium-226 and radium-228 concentrations greater than 5 pCi/L in samples from the Vincentown and Wenonah-Mount Laurel aquifers and the Englishtown aquifer system was not nearly as common as in samples from the Kirkwood-Cohansey aquifer system, likely because of the slightly higher pH of water from these aquifers relative to that of Kirkwood-Cohansey aqu

  8. Radionuclide tracers of sediment-water interactions on the Amazon shelf

    NASA Astrophysics Data System (ADS)

    Moore, Willard S.; DeMaster, David J.; Smoak, Joseph M.; McKee, Brent A.; Swarzenski, Peter W.

    1996-04-01

    A comprehensive study of a variety of radionuclide tracers has been coupled with other geochemical investigations and with sedimentary and physical oceanographic measurements to elucidate processes and their characteristic time scales at the mouth of the Amazon River. This two-year field study on the Amazon continental shelf involved four cruises designed to provide information during different stages of the river hydrograph. Although the cruises were coordinated with river stage, other physical variables including spring-neap tidal stages, the flow of the North Brazil Current and trade-wind stress caused important effects on the shelf environment. Partitioning of uranium among dissolved, colloidal and particulate phases was investigated during AmasSeds. A detailed examination of uranium water-column behavior during low river discharge found that most (89%) of the uranium near the Amazon River mouth was associated with the particulate phase and that most (92%) of the riverine dissolved-phase uranium was in the colloidal size fraction (0.001-0.4 μm). A non-conservative uranium/salinity distribution was observed for dissolved uranium, indicating large-scale uranium removal from surface waters with salinities less than 20 ppt. Colloidal uranium was non-conservative across the entire salinity regime, exhibiting removal of colloidal uranium from waters with salinities less than 12 ppt and a significant input at higher salinities. A short-lived particle-reactive tracer, 234Th, was used to evaluate the rates of particle scavenging on the shelf. Suspended-sediment concentrations respond to each turn of the tide, thus limiting the time available for equilibrium to be established between the particles and the tracers. Experiments demonstrated that on the Amazon shelf the partitioning and distribution of trace elements are governed by particle dynamics (particle residence times < sorption times). The high suspended load, including fluid muds, retards the incorporation of adsorbed 234Th into the seabed. Once scavenged, 234Th remains part of the suspended-sediment and fluid-mud inventory for periods of at least 4-8 weeks. Another particle-reactive tracer, 210Pb, was used to evaluate the potential supply of reactive metals from offshore waters to the shelf. As open-ocean waters move into the Amazon mixing zone, in response to the estuarine-like circulation, they lose 210Ph through scavenging processes associated with delta formation. This oceanic input of 210Pb dominates other inputs to the Amazon shelf system. Based on 210Pb analyses from more than 40 ☐ and kasten cores, the flux of water moving shoreward and depositing 210Pb in the sediments was calculated to be on the order of 6 × 10 161y -1 ˜10 times the riverine flux from the Amazon. The distribution of 210Pb in the sediments suggests that if particle-reactive species (such as certain trace metals) are released in dissolved form on the shelf, they will be scavenged quickly in this turbid environment, with the largest inventories occurring in the foreset beds (although the highest concentrations occur in the bottomset beds). The large landward flow of water indicates that if particle-reactive species are released in the western equatorial Atlantic via aerosol transport or other mechanisms, there is a good chance that a sizeable portion will be buried in the Amazon delta. Fluxes of radium isotopes, 226Ra, 228Ra and 224Ra, from the bottom sediments were used to evaluate sediment resuspension across the shelf. The average flux of 226Ra from the Amazon shelf balanced the annual desorption of 226Ra from river-derived sediments; however, departures between the 226Ra flux and sediment necessary to support the flux occurred for different sampling periods. During falling and low discharge, less sediment entered the system than was required to support the sedimentary desorption 226Ra flux. During rising and high discharge, more sediment entered than was necessary to sustain the 226Ra flux. Considerable recycling of particles between the seabed and water column was required to wash away most of the desorbable 226Ra from the sediment. To support the sedimentary 228Ra flux, 3.4 × 10 16 g of sediment must be resuspended each year. Such mixing would resuspend the top 35 em of sediment over the entire shelf each year, or mix the surface layer (SL, the region of uniform sedimentary 210Pb depth profiles) to a depth of 90 cm annually. Such mixing would turn over the entire SL every 1-2 years. Desorption of sedimentary radium isotopes must be accompanied by the desorption of other exchangeable species including phosphate, cesium and cadmium. Correlations among phosphate and radium isotopes, infer that phosphate is being released from bottom sediments as the sediments are resuspended into the water column. As was the case for 226Ra, bottom sediment must be repeatedly suspended into the water column to release all of the exchangeable phosphate. The desorption of 224Ra from shelf sediments provides a tracer of the Amazon plume into the Atlantic. In July and September 1989, the ship crossed the Demerara retroflection 380 km from the Amazon shelf and excess 224Ra activities up to 8 dpm 100 kg -1 were measured. It was concluded that these waters were <5 days removed from the Amazon shelf. A sustained current of >80 em s -1 would be required to advect the water this distance in <5 days, an observation that agrees well with drogue releases during August 1989.

  9. Uranium and other contaminants in hair from the parents of children with congenital anomalies in Fallujah, Iraq

    PubMed Central

    2011-01-01

    Background Recent reports have drawn attention to increases in congenital birth anomalies and cancer in Fallujah Iraq blamed on teratogenic, genetic and genomic stress thought to result from depleted Uranium contamination following the battles in the town in 2004. Contamination of the parents of the children and of the environment by Uranium and other elements was investigated using Inductively Coupled Plasma Mass Spectrometry. Hair samples from 25 fathers and mothers of children diagnosed with congenital anomalies were analysed for Uranium and 51 other elements. Mean ages of the parents was: fathers 29.6 (SD 6.2); mothers: 27.3 (SD 6.8). For a sub-group of 6 women, long locks of hair were analysed for Uranium along the length of the hair to obtain information about historic exposures. Samples of soil and water were also analysed and Uranium isotope ratios determined. Results Levels of Ca, Mg, Co, Fe, Mn, V, Zn, Sr, Al, Ba, Bi, Ga, Pb, Hg, Pd and U (for mothers only) were significantly higher than published mean levels in an uncontaminated population in Sweden. In high excess were Ca, Mg, Sr, Al, Bi and Hg. Of these only Hg can be considered as a possible cause of congenital anomaly. Mean levels for Uranium were 0.16 ppm (SD: 0.11) range 0.02 to 0.4, higher in mothers (0.18 ppm SD 0.09) than fathers (0.11 ppm; SD 0.13). The highly unusual non-normal Fallujah distribution mean was significantly higher than literature results for a control population Southern Israel (0.062 ppm) and a non-parametric test (Mann Whitney-Wilcoxon) gave p = 0.016 for this comparison of the distribution. Mean levels in Fallujah were also much higher than the mean of measurements reported from Japan, Brazil, Sweden and Slovenia (0.04 ppm SD 0.02). Soil samples show low concentrations with a mean of 0.76 ppm (SD 0.42) and range 0.1-1.5 ppm; (N = 18). However it may be consistent with levels in drinking water (2.28 μgL-1) which had similar levels to water from wells (2.72 μgL-1) and the river Euphrates (2.24 μgL-1). In a separate study of a sub group of mothers with long hair to investigate historic Uranium excretion the results suggested that levels were much higher in the past. Uranium traces detected in the soil samples and the hair showed slightly enriched isotopic signatures for hair U238/U235 = (135.16 SD 1.45) compared with the natural ratio of 137.88. Soil sample Uranium isotope ratios were determined after extraction and concentration of the Uranium by ion exchange. Results showed statistically significant presence of enriched Uranium with a mean of 129 with SD5.9 (for this determination, the natural Uranium 95% CI was 132.1 < Ratio < 144.1). Conclusions Whilst caution must be exercised about ruling out other possibilities, because none of the elements found in excess are reported to cause congenital diseases and cancer except Uranium, these findings suggest the enriched Uranium exposure is either a primary cause or related to the cause of the congenital anomaly and cancer increases. Questions are thus raised about the characteristics and composition of weapons now being deployed in modern battlefields PMID:21888647

  10. Tracing the Origin of Radioactivity in Groundwater from the Negev, Israel

    NASA Astrophysics Data System (ADS)

    Vengosh, A.; Pery, N.; Paytan, A.; Haquin, G.; Enhanany, S.; Pankratov, I.

    2004-12-01

    In normal groundwater conditions natural radionuclides are typically retained on the aquifer matrix and their activity in the groundwater is low. Radium is exceptional since the ratio between adsorbed and dissolved radium depends the ionic strength of the solution. Under high salinity radium is rapidly desorbed and accumulates in the liquid phase. Here we report the results of a geochemical study that investigates the origin of radioactivity in brackish to saline groundwater from the Negev and Arava Valley, Israel. We use the Ra isotope quartet (226Ra-half life 1600 y, 228Ra - 5.6 y, 224Ra - 3.6 d, 223Ra - 11.4 d) to discriminate between radioactivity derived from a thorium source (high 228Ra/226Ra and 224Ra/223Ra ratios) found in groundwater flowing in the Nubian Sandstone aquifer and an uranium source (low 228Ra/226Ra and 224Ra/223Ra ratios) in groundwater flowing in carbonate (Upper Cretaceous) aquifer. We show that the activity of 226Ra in groundwater from the carbonate aquifer is positively correlated with that of the salinity. In the Nubian Sandstone aquifer, however, no such correlation was found. Instead, we observed an inverse correlation between 228Ra activity and sulfate and a positive correlation with barium contents. Given the high H2S content of the ground water, we hypothesized that sulfate reduction process triggers radium leaching to the water, probably due to barite dissolution and anoxic conditions in the aquifer. These findings indicate that high radioactivity can also be found even in low-saline groundwater and that the isotopic ratios of radium are sensitive tracers for the water-rock interactions and thus reconstructing the flow paths in different aquifer matrix (i.e., carbonate versus sandstone).

  11. Use of U and Th Decay-Series Disequilibrium to Characterize Geothermal Systems: An Example from the Coso Geothermal System

    NASA Astrophysics Data System (ADS)

    Leslie, B. W.; Hammond, D.

    2007-12-01

    Uranium and thorium decay series isotopes were measured in fluids and solids in the Coso geothermal system to assess the utility and constrain the limitations of the radioisotopic approach to the investigation of rock-water interaction. Fluid radioisotope measurements indicate substantial kilometer-scale variability in chemistry. Between 1988 and 1990, radium isotope activity ratios indicate temporal variability, which is exhibited by apparent mixing relationships observed as a function of time for single wells. Activity ratios of Ra-224/Ra-226 and Ra- 228/Ra-226, and the processes that contribute and remove these radionuclide to and from the fluids, constrain residence times of fluids and may help constrain fluid velocities in the geothermal system. Activity ratios of Ra- 224/Ra-226 > ten were measured. In groundwater and geothermal systems ratios of Ra-224/Ra-226 > ten are limited to zones of thermal upwelling or very young (days to weeks) waters in mountainous areas. Rn-222 results indicate that radon is also an effective tracer for steam velocities within the geothermal system. Analysis of carbon dioxide and Rn-222 data indicates that the residence time of steam (time since separation from the liquid) is short (probably less than four days). Estimates of fluid velocities derived from Rn-222 and radium isotopic measurements are within an order of magnitude of velocities derived from a fluorescein tracer test. Both Rn-222 and Ra-224 activities are higher in single-phase fluids in the northwest as compared to the southeast, indicating a higher rock-surface-area/water-volume ratio in the northwest. Thus, measurements of short-lived radioisotopes and gaseous phase constituents can constrain processes and characteristics of geothermal systems that are usually difficult to constrain (e.g., surface area/volume, residence times). The NRC staff views expressed herein are preliminary and do not constitute a final judgment or determination of the matters addressed or of the acceptability of a license application for a geologic repository at Yucca Mountain.

  12. Increased Concentrations of Short-Lived Decay-Series Radionuclides in Groundwaters Underneath the Nopal I Uranium Deposit at Pena Blanca, Mexico

    NASA Astrophysics Data System (ADS)

    Luo, S.; Ku, T.; Todd, V.; Murrell, M. T.; Dinsmoor, J. C.

    2007-05-01

    The Nopal I uranium ore deposit at Pena Blanca, Mexico, located at > 200 meters above the groundwater table, provides an ideal natural analog for quantifying the effectiveness of geological barrier for isolation of radioactive waste nuclides from reaching the human environments through ground water transport. To fulfill such natural analog studies, three wells (PB1, PB2, and PB3 respectively) were drilled at the site from the land surface down to the saturated groundwater zone and ground waters were collected from each of these wells through large- volume sampling/in-situ Mn-filter filtration for analyses of short-lived uranium/thorium-series radionuclides. Our measurements from PB1 show that the groundwater standing in the hole has much lower 222Rn activity than the freshly pumped groundwater. From this change in 222Rn activity, we estimate the residence time of groundwater in PB1 to be about 20 days. Our measurements also show that the activities of short-lived radioisotopes of Th (234Th), Ra (228Ra, 224Ra, 223Ra), Rn (222Rn), Pb (210Pb), and Po (210Po) in PB1, PB2, and PB3 are all significantly higher than those from the other wells near the Nopal I site. These high activities provide evidence for the enrichment of long-lived U and Ra isotopes in the groundwater as well as in the associated adsorbed phases on the fractured aquifer rocks underneath the ore deposit. Such enrichment suggests a rapid dissolution of U and Ra isotopes from the uranium ore deposit in the vadose zone and the subsequent migration to the groundwater underneath. A reactive transport model can be established to characterize the in-situ transport of radionuclides at the site. The observed change of 222Rn activity at PB1 also suggests that the measured high radioactivityies in ground waters from the site isare not an artifact of drilling operations. However, further studies are needed to assess if or to what extent the radionuclide migration is affected by the previous mining activities at the site.

  13. Soil and vegetation influence in plants natural radionuclides uptake at a uranium mining site

    NASA Astrophysics Data System (ADS)

    Charro, E.; Moyano, A.

    2017-12-01

    The main objective of this work is to investigate the uptake of several radionuclides by the vegetation characteristic of a dehesa ecosystem in uranium mining-impacted soils in Central-West of Spain. The activity concentration for 238U, 226Ra, 210Pb, 232Th, and 224Ra was measured in soil and vegetation samples using a Canberra n-type HPGe gamma-ray spectrometer. Transfer factors of natural radionuclides in different tissues (leaves, branches, twigs, and others) of native plants were evaluated. From these data, the influence of the mine, the physicochemical parameters of the soils and the type of vegetation were analyzed in order to explain the accumulation of radionuclides in the vegetation. A preferential uptake of 210Pb and 226Ra by plants, particularly by trees of the Quercus species (Quercus pyrenaica and Quercus ilex rotundifolia), has been observed, being the transfer factors for 226Ra and 210Pb in these tree species higher than those for other plants (like Pinus pinaster, Rubur ulmifolius and Populus sp.). The analysis of radionuclide contents and transfer factors in the vegetation showed no evidence of influence of the radionuclide concentration in soils, although it could be explained in terms of the type of plants and, in particular, of the tree's species, with special attention to the tree's rate of growth, being higher in slow growing species.

  14. Determination of natural radioactivity in irrigation water of drilled wells in northwestern Saudi Arabia.

    PubMed

    Alkhomashi, N; Al-Hamarneh, Ibrahim F; Almasoud, Fahad I

    2016-02-01

    The levels of natural radiation in bedrock groundwater extracted from drilled wells in selected farms in the northwestern part of Saudi Arabia were addressed. The investigated waters form a source of irrigation for vegetables, agricultural crops, wheat, and alfalfa to feed livestock consumed by the general public. Information about water radioactivity in this area is not available yet. Therefore, this study strives to contribute to the quality assessment of the groundwater of these wells that are drilled into the non-renewable Saq sandstone aquifer. Hence, gross alpha and beta activities as well as the concentrations of (224)Ra, (226)Ra, (228)Ra, (234)U, (238)U, and U(total) were measured, compared to national and international limits and contrasted with data quoted from the literature. Correlations between the activities of the analyzed radionuclides were discussed. The concentrations of gross alpha and beta activities as well as (228)Ra were identified by liquid scintillation counting whereas alpha spectrometry was used to determine (224)Ra, (226)Ra, (234)U and (238)U after separation from the matrix by extraction chromatography. The mean activity concentrations of gross α and β were 3.15 ± 0.26 Bq L(-1) and 5.39 ± 0.44 Bq L(-1), respectively. Radium isotopes ((228)Ra and (226)Ra) showed mean concentrations of 3.16 ± 0.17 Bq L(-1) and 1.12 ± 0.07 Bq L(-1), respectively, whereas lower levels of uranium isotopes ((234)U and (238)U) were obtained. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Maomao; Deng, Xiaodong; Ying, Qi

    2015-05-01

    MicroRNA-224 is overexpressed in various malignant tumors with poor prognosis, which plays a critical role in biological processes including cell proliferation, apoptosis and several developmental and physiological progressions. However, the potential association between miR-224 and clinical outcome in patients with meningiomas remains unknown. Here, we investigate miR-224 expression and biological functions in meningiomas. MiR-224 expression was measured by Northern blot analysis and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in meningioma and normal brain tissues. Kaplan–Meier analysis and Cox regression analysis were used to exam its correlation with clinicopathological features and prognostic value. The biological effects of miR-224 on the cellmore » proliferation and apoptosis in meningioma cells were examined by MTT assay and apoptosis assay. We found the expression levels of miR-224 were significantly higher in meningioma tissues than that in normal brain, positively correlated with advanced pathological grade. Kaplan–Meier analysis indicated that meningioma patients with low miR-224 expression exhibited significantly prolonged overall and recurrence-free survival. Furthermore, we demonstrated that ERG2 was an identical candidate target gene of MiR-224 in vitro. Our results indicated that downregulation of miR-224 suppressed cell growth and resulted in the enhancement of cell apoptosis through activation of the ERG2-BAK-induced apoptosis pathway. Our findings imply the miR-224 expression could predict the overall survival and recurrence-free survival of patients with meningioma and it might be a promising therapeutic target for treating malignant meningiomas. - Highlights: • MiR-224 expression is correlates with prognosis in meningioma patients. • ERG2 is a novel downstream target of miR-224. • MiR-224 suppressed cell growth and enhanced apoptosis in IOMM-Lee and CH157 cells. • MiR-224 is an upstream regulator of the ERG2-BAK-induced apoptosis pathway.« less

  16. Sequential extraction procedure for determination of uranium, thorium, radium, lead and polonium radionuclides by alpha spectrometry in environmental samples

    NASA Astrophysics Data System (ADS)

    Oliveira, J. M.; Carvalho, F. P.

    2006-01-01

    A sequential extraction technique was developed and tested for common naturally-occurring radionuclides. This technique allows the extraction and purification of uranium, thorium, radium, lead, and polonium radionuclides from the same sample. Environmental materials such as water, soil, and biological samples can be analyzed for those radionuclides without matrix interferences in the quality of radioelement purification and in the radiochemical yield. The use of isotopic tracers (232U, 229Th, 224Ra, 209Po, and stable lead carrier) added to the sample in the beginning of the chemical procedure, enables an accurate control of the radiochemical yield for each radioelement. The ion extraction procedure, applied after either complete dissolution of the solid sample with mineral acids or co-precipitation of dissolved radionuclide with MnO2 for aqueous samples, includes the use of commercially available pre-packed columns from Eichrom® and ion exchange columns packed with Bio-Rad resins, in altogether three chromatography columns. All radioactive elements but one are purified and electroplated on stainless steel discs. Polonium is spontaneously plated on a silver disc. The discs are measured using high resolution silicon surface barrier detectors. 210Pb, a beta emitter, can be measured either through the beta emission of 210Bi, or stored for a few months and determined by alpha spectrometry through the in-growth of 210Po. This sequential extraction chromatography technique was tested and validated with the analysis of certified reference materials from the IAEA. Reproducibility was tested through repeated analysis of the same homogeneous material (water sample).

  17. 25 CFR 224.59 - How will the Director use the results of the application consultation meeting?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... consultation meeting? 224.59 Section 224.59 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF... information provided through §§ 224.53 and 224.63 to determine the energy resource development capacity of the...

  18. 49 CFR 224.103 - Characteristics of retroreflective sheeting.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Characteristics of retroreflective sheeting. 224.103 Section 224.103 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... Application, Inspection, and Maintenance of Retroreflective Material § 224.103 Characteristics of...

  19. 49 CFR 224.103 - Characteristics of retroreflective sheeting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Characteristics of retroreflective sheeting. 224.103 Section 224.103 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL... Application, Inspection, and Maintenance of Retroreflective Material § 224.103 Characteristics of...

  20. 40 CFR 415.224 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 30 2012-07-01 2012-07-01 false [Reserved] 415.224 Section 415.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Titanium Dioxide Production Subcategory § 415.224...

  1. 40 CFR 415.224 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 30 2013-07-01 2012-07-01 true [Reserved] 415.224 Section 415.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Titanium Dioxide Production Subcategory § 415.224...

  2. 40 CFR 415.224 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 29 2011-07-01 2009-07-01 true [Reserved] 415.224 Section 415.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Titanium Dioxide Production Subcategory § 415.224...

  3. 40 CFR 415.224 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 415.224 Section 415.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Titanium Dioxide Production Subcategory § 415.224...

  4. 40 CFR 415.224 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 29 2014-07-01 2012-07-01 true [Reserved] 415.224 Section 415.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS INORGANIC CHEMICALS MANUFACTURING POINT SOURCE CATEGORY Titanium Dioxide Production Subcategory § 415.224...

  5. MiR-224 expression increases radiation sensitivity of glioblastoma cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Upraity, Shailendra; Kazi, Sadaf; Padul, Vijay

    Highlights: • MiR-224 expression in established glioblastoma cell lines and sporadic tumor tissues is low. • Exogenous miR-224 expression was found to increase radiation sensitivity of glioblastoma cells. • MiR-224 expression brought about 55–60% reduction in API5 expression levels. • Transfection with API5 siRNA increased radiation sensitivity of glioblastoma cells. • Low miR-224 and high API5 expression correlated with worse survival of GBM patients. - Abstract: Glioblastoma (GBM) is the most common and highly aggressive primary malignant brain tumor. The intrinsic resistance of this brain tumor limits the efficacy of administered treatment like radiation therapy. In the present study, effectmore » of miR-224 expression on growth characteristics of established GBM cell lines was analyzed. MiR-224 expression in the cell lines as well as in primary GBM tumor tissues was found to be low. Exogenous transient expression of miR-224 using either synthetic mimics or stable inducible expression using doxycycline inducible lentiviral vector carrying miR-224 gene, was found to bring about 30–55% reduction in clonogenic potential of U87 MG cells. MiR-224 expression reduced clonogenic potential of U87 MG cells by 85–90% on irradiation at a dose of 6 Gy, a dose that brought about 50% reduction in clonogenic potential in the absence of miR-224 expression. MiR-224 expression in glioblastoma cells resulted in 55–65% reduction in the expression levels of API5 gene, a known target of miR-224. Further, siRNA mediated down-regulation of API5 was also found to have radiation sensitizing effect on glioblastoma cell lines. Analysis of the Cancer Genome Atlas data showed lower miR-224 expression levels in male GBM patients to correlate with poorer survival. Higher expression levels of miR-224 target API5 also showed significant correlation with poorer survival of GBM patients. Up-regulation of miR-224 or down-regulation of its target API5 in combination with radiation therapy, therefore appear as promising options for the treatment of glioblastoma, which is refractory to the existing treatment strategies.« less

  6. 49 CFR 224.3 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Applicability. 224.3 Section 224.3 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.3 Applicability. This part applies to...

  7. 49 CFR 224.105 - Sheeting dimensions and quantity.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Sheeting dimensions and quantity. 224.105 Section 224.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., Inspection, and Maintenance of Retroreflective Material § 224.105 Sheeting dimensions and quantity...

  8. 49 CFR 224.105 - Sheeting dimensions and quantity.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Sheeting dimensions and quantity. 224.105 Section 224.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., Inspection, and Maintenance of Retroreflective Material § 224.105 Sheeting dimensions and quantity...

  9. 49 CFR 224.105 - Sheeting dimensions and quantity.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Sheeting dimensions and quantity. 224.105 Section 224.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., Inspection, and Maintenance of Retroreflective Material § 224.105 Sheeting dimensions and quantity...

  10. 49 CFR 224.105 - Sheeting dimensions and quantity.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Sheeting dimensions and quantity. 224.105 Section 224.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., Inspection, and Maintenance of Retroreflective Material § 224.105 Sheeting dimensions and quantity...

  11. 49 CFR 224.105 - Sheeting dimensions and quantity.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Sheeting dimensions and quantity. 224.105 Section 224.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., Inspection, and Maintenance of Retroreflective Material § 224.105 Sheeting dimensions and quantity...

  12. Occurrence and hydrogeochemistry of radiochemical constituents in groundwater of Jefferson County and surrounding areas, southwestern Montana, 2007 through 2010

    USGS Publications Warehouse

    Caldwell, Rodney R.; Nimick, David A.; DeVaney, Rainie M.

    2014-01-01

    The U.S. Geological Survey, in cooperation with Jefferson County and the Jefferson Valley Conservation District, sampled groundwater in southwestern Montana to evaluate the occurrence and concentration of naturally-occurring radioactive constituents and to identify geologic settings and environmental conditions in which elevated concentrations occur. A total of 168 samples were collected from 128 wells within Broadwater, Deer Lodge, Jefferson, Lewis and Clark, Madison, Powell, and Silver Bow Counties from 2007 through 2010. Most wells were used for domestic purposes and were primary sources of drinking water for individual households. Water-quality samples were collected from wells completed within six generalized geologic units, and analyzed for constituents including uranium, radon, gross alpha-particle activity, and gross beta-particle activity. Thirty-eight wells with elevated concentrations or activities were sampled a second time to examine variability in water quality throughout time. These water-quality samples were analyzed for an expanded list of radioactive constituents including the following: three isotopes of uranium (uranium-234, uranium-235, and uranium-238), three isotopes of radium (radium-224, radium-226, and radium-228), and polonium-210. Existing U.S. Geological Survey and Montana Bureau of Mines and Geology uranium and radon water-quality data collected as part of other investigations through 2011 from wells within the study area were compiled as part of this investigation. Water-quality data from this study were compared to data collected nationwide by the U.S. Geological Survey through 2011. Radionuclide samples for this study typically were analyzed within a few days after collection, and therefore data for this study may closely represent the concentrations and activities of water being consumed locally from domestic wells. Radioactive constituents were detected in water from every well sampled during this study regardless of location or geologic unit. Nearly 41 percent of sampled wells had at least one radioactive constituent concentration that exceeded U.S. Environmental Protection Agency drinking-water standards or screening levels. Uranium concentrations were higher than the U.S. Environmental Protection Agency maximum contaminant level (MCL) of 30 micrograms per liter in samples from 14 percent of the wells. Radon concentrations exceeded a proposed MCL of 4,000 picocuries per liter in 27 percent of the wells. Combined radium (radium-226 and radium-228) exceeded the MCL of 5 picocuries per liter in samples from 10 of 47 wells. About 40 percent (42 of 104 wells) of the wells had gross alpha-particle activities (72-hour count) at or greater than a screening level of 15 pCi/L. Gross beta-particle activity exceeded the U.S. Environmental Protection Agency 50 picocuries per liter screening level in samples from 5 of 104 wells. Maximum radium-224 and polonium-210 activities in study wells were 16.1 and 3.08 picocuries per liter, respectively; these isotopes are constituents of human-health concern, but the U.S. Environmental Protection Agency has not established MCLs for them. Radioactive constituent concentrations or activities exceeded at least one established drinking-water standard, proposed drinking-water standard, or screening level in groundwater samples from five of six generalized geologic units assessed during this study. Radioactive constituent concentrations or activities were variable not only within each geologic unit, but also among wells that were completed in the same geologic unit and in close proximity to one another. Established or proposed drinking-water standards were exceeded most frequently in water from wells completed in the generalized geologic unit that includes rocks of the Boulder batholith and other Tertiary through Cretaceous igneous intrusive rocks (commonly described as granite). Specifically, of the wells completed in the Boulder batholith and related rocks sampled as part of this study, 24 percent exceeded the MCL of 30 micrograms per liter for uranium, 50 percent exceeded the proposed alternative MCL of 4,000 picocuries per liter for radon, and 27 percent exceeded the MCL of 5 micrograms per liter for combined radium-226 and radium-228. Elevated radioactive constituent values were detected in samples representing a large range of field properties and water types. Correlations between radioactive constituents and pH, dissolved oxygen, and most major ions were not statistically significant (p-value > 0.05) or were weakly correlated with Spearman correlation coefficients (rho) ranging from -0.5 to 0.5. Moderate correlations did exist between gross beta-particle activity and potassium (rho = 0.72 to 0.82), likely because one potassium isotope (potassium-40) is a beta-particle emitter. Total dissolved solids and specific conductance also were moderately correlated (rho = 0.62 to 0.71) with gross alpha-particle and gross beta-particle activity, indicating that higher radioactivity values can be associated with higher total dissolved solids. Correlations were evaluated among radioactive constituents. Moderate to strong correlations occurred between gross alpha-particle and beta-particle activities (rho = 0.77 to 0.96) and radium isotopes (rho = 0.78 to 0.92). Correlations between gross alpha-particle activity (72-hour count) and all analyzed radioactive constituents were statistically significant (p-value Radiochemical results varied temporally in samples from several of the thirty-eight wells sampled at least twice during the study. The time between successive sampling events ranged from about 1 to 10 months for 29 wells to about 3 years for the other 9 wells. Radiochemical constituents that varied by greater than 30 percent between sampling events included uranium (29 percent of the resampled wells), and radon (11 percent of the resampled wells), gross alpha-particle activity (38 percent of the resampled wells), and gross beta-particle activity (15 percent of the resampled wells). Variability in uranium concentrations from two wells was sufficiently large that concentrations were less than the MCL in the first set of samples and greater than the MCL in the second. Sample holding times affect analytical results in this study. Gross alpha-particle and gross beta-particle activities were measured twice, 72 hours and 30 days after sample collection. Gross alpha-particle activity decreased an average of 37 percent between measurements, indicating the presence of short-lived alpha-emitting radionuclides in these samples. Gross beta-particle activity increased an average of 31 percent between measurements, indicating ingrowth of longer-lived beta-emitting radionuclides.

  13. Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice.

    PubMed

    Westrøm, Sara; Malenge, Marion; Jorstad, Ida Sofie; Napoli, Elisa; Bruland, Øyvind S; Bønsdorff, Tina B; Larsen, Roy H

    2018-05-30

    Internal therapy with α-emitters should be well suited for micrometastatic disease. Radium-224 emits multiple α-particles through its decay and has a convenient 3.6 days of half-life. Despite its attractive properties, the use of 224 Ra has been limited to bone-seeking applications because it cannot be stably bound to a targeting molecule. Alternative delivery systems for 224 Ra are therefore of considerable interest. In this study, calcium carbonate microparticles are proposed as carriers for 224 Ra, designed for local therapy of disseminated cancers in cavitary regions, such as peritoneal carcinomatosis. Calcium carbonate microparticles were radiolabeled by precipitation of 224 Ra on the particle surface, resulting in high labeling efficiencies for both 224 Ra and daughter 212 Pb and retention of more than 95% of these nuclides for up to 1 week in vitro. The biodistribution after intraperitoneal administration of the 224 Ra-labeled CaCO 3 microparticles in immunodeficient mice revealed that the radioactivity mainly remained in the peritoneal cavity. In addition, the systemic distribution of 224 Ra was found to be strongly dependent on the amount of administered microparticles, with a reduced skeletal uptake of 224 Ra with increasing dose. The results altogether suggest that the 224 Ra-labeled CaCO 3 microparticles have promising properties for use as a localized internal α-therapy of cavitary cancers. © 2018 Oncoinvent AS. Journal of Labelled Compounds and Radiopharmaceuticals Published by John Wiley & Sons, Ltd.

  14. Ra‐224 labeling of calcium carbonate microparticles for internal α‐therapy: Preparation, stability, and biodistribution in mice

    PubMed Central

    Westrøm, Sara; Malenge, Marion; Jorstad, Ida Sofie; Napoli, Elisa; Bruland, Øyvind S.; Bønsdorff, Tina B.

    2018-01-01

    Internal therapy with α‐emitters should be well suited for micrometastatic disease. Radium‐224 emits multiple α‐particles through its decay and has a convenient 3.6 days of half‐life. Despite its attractive properties, the use of 224Ra has been limited to bone‐seeking applications because it cannot be stably bound to a targeting molecule. Alternative delivery systems for 224Ra are therefore of considerable interest. In this study, calcium carbonate microparticles are proposed as carriers for 224Ra, designed for local therapy of disseminated cancers in cavitary regions, such as peritoneal carcinomatosis. Calcium carbonate microparticles were radiolabeled by precipitation of 224Ra on the particle surface, resulting in high labeling efficiencies for both 224Ra and daughter 212Pb and retention of more than 95% of these nuclides for up to 1 week in vitro. The biodistribution after intraperitoneal administration of the 224Ra‐labeled CaCO3 microparticles in immunodeficient mice revealed that the radioactivity mainly remained in the peritoneal cavity. In addition, the systemic distribution of 224Ra was found to be strongly dependent on the amount of administered microparticles, with a reduced skeletal uptake of 224Ra with increasing dose. The results altogether suggest that the 224Ra‐labeled CaCO3 microparticles have promising properties for use as a localized internal α‐therapy of cavitary cancers. PMID:29380410

  15. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  16. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  17. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  18. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  19. 49 CFR 195.224 - Welding: Weather.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Welding: Weather. 195.224 Section 195.224 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Construction § 195.224 Welding: Weather. Welding must be protected from weather conditions that...

  20. 50 CFR 224.103 - Special prohibitions for endangered marine mammals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... marine mammals. 224.103 Section 224.103 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS ENDANGERED MARINE AND ANADROMOUS SPECIES § 224.103 Special prohibitions for endangered marine mammals. (a) Approaching...

  1. 49 CFR 224.15 - Special approval procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Special approval procedures. 224.15 Section 224.15 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.15 Special approval...

  2. 49 CFR 224.7 - Waivers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Waivers. 224.7 Section 224.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.7 Waivers. (a) Any person subject to...

  3. 49 CFR 224.106 - Location of retroreflective sheeting.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Location of retroreflective sheeting. 224.106 Section 224.106 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD..., Inspection, and Maintenance of Retroreflective Material § 224.106 Location of retroreflective sheeting. (a...

  4. 49 CFR 384.224 - Noncommercial motor vehicle violations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Noncommercial motor vehicle violations. 384.224 Section 384.224 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... § 384.224 Noncommercial motor vehicle violations. The State must have and enforce laws and/or...

  5. 49 CFR 384.224 - Noncommercial motor vehicle violations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Noncommercial motor vehicle violations. 384.224 Section 384.224 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... § 384.224 Noncommercial motor vehicle violations. The State must have and enforce laws and/or...

  6. 40 CFR 224.2 - Reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Reports. 224.2 Section 224.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING RECORDS AND REPORTS REQUIRED OF OCEAN DUMPING PERMITTEES UNDER SECTION 102 OF THE ACT § 224.2 Reports. (a) Periodic reports...

  7. 40 CFR 224.2 - Reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Reports. 224.2 Section 224.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING RECORDS AND REPORTS REQUIRED OF OCEAN DUMPING PERMITTEES UNDER SECTION 102 OF THE ACT § 224.2 Reports. (a) Periodic reports...

  8. 40 CFR 86.224-94 - Carbon dioxide analyzer calibration.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Carbon dioxide analyzer calibration. 86.224-94 Section 86.224-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... New Medium-Duty Passenger Vehicles; Cold Temperature Test Procedures § 86.224-94 Carbon dioxide...

  9. 23 CFR 450.224 - Phase-in of new requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Phase-in of new requirements. 450.224 Section 450.224 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.224 Phase-in of new...

  10. 23 CFR 450.224 - Phase-in of new requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Phase-in of new requirements. 450.224 Section 450.224 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.224 Phase-in of new...

  11. 23 CFR 450.224 - Phase-in of new requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Phase-in of new requirements. 450.224 Section 450.224 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.224 Phase-in of new...

  12. 22 CFR 224.14 - Separation of functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Separation of functions. 224.14 Section 224.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.14 Separation of functions. (a) The investigating official, the reviewing official, and any...

  13. 23 CFR 450.224 - Phase-in of new requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Phase-in of new requirements. 450.224 Section 450.224 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING ASSISTANCE AND STANDARDS Statewide Transportation Planning and Programming § 450.224 Phase-in of new...

  14. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  15. 40 CFR 52.224 - General requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 3 2014-07-01 2014-07-01 false General requirements. 52.224 Section 52.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.224 General requirements. (a) The requirements of § 51.116(c) of this chapter are...

  16. 40 CFR 52.224 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false General requirements. 52.224 Section 52.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.224 General requirements. (a) The requirements of § 51.116(c) of this chapter are...

  17. 40 CFR 52.224 - General requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 3 2012-07-01 2012-07-01 false General requirements. 52.224 Section 52.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.224 General requirements. (a) The requirements of § 51.116(c) of this chapter are...

  18. 40 CFR 52.224 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 3 2011-07-01 2011-07-01 false General requirements. 52.224 Section 52.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.224 General requirements. (a) The requirements of § 51.116(c) of this chapter are...

  19. 40 CFR 52.224 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 3 2013-07-01 2013-07-01 false General requirements. 52.224 Section 52.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS California § 52.224 General requirements. (a) The requirements of § 51.116(c) of this chapter are...

  20. 22 CFR 224.31 - Determining the amount of penalties and assessments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... assessments. 224.31 Section 224.31 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.31 Determining the amount of penalties and assessments. (a) In determining an appropriate amount of civil penalties and assessments, the ALJ and the A.I.D...

  1. 22 CFR 224.31 - Determining the amount of penalties and assessments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... assessments. 224.31 Section 224.31 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.31 Determining the amount of penalties and assessments. (a) In determining an appropriate amount of civil penalties and assessments, the ALJ and the A.I.D...

  2. 22 CFR 224.31 - Determining the amount of penalties and assessments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... assessments. 224.31 Section 224.31 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.31 Determining the amount of penalties and assessments. (a) In determining an appropriate amount of civil penalties and assessments, the ALJ and the A.I.D...

  3. 22 CFR 224.31 - Determining the amount of penalties and assessments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... assessments. 224.31 Section 224.31 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.31 Determining the amount of penalties and assessments. (a) In determining an appropriate amount of civil penalties and assessments, the ALJ and the A.I.D...

  4. 22 CFR 224.31 - Determining the amount of penalties and assessments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... assessments. 224.31 Section 224.31 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.31 Determining the amount of penalties and assessments. (a) In determining an appropriate amount of civil penalties and assessments, the ALJ and the A.I.D...

  5. 42 CFR 93.224 - Research record.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Research record. 93.224 Section 93.224 Public... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions § 93.224 Research record. Research record means the record of data or results that...

  6. 42 CFR 93.224 - Research record.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Research record. 93.224 Section 93.224 Public... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions § 93.224 Research record. Research record means the record of data or results that...

  7. 42 CFR 93.224 - Research record.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Research record. 93.224 Section 93.224 Public... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions § 93.224 Research record. Research record means the record of data or results that...

  8. 42 CFR 93.224 - Research record.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Research record. 93.224 Section 93.224 Public... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions § 93.224 Research record. Research record means the record of data or results that...

  9. 42 CFR 93.224 - Research record.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Research record. 93.224 Section 93.224 Public... EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Definitions § 93.224 Research record. Research record means the record of data or results that...

  10. 75 FR 71790 - Second Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held December 9, 2010...

  11. 75 FR 80886 - Third Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held January 13, 2011...

  12. 76 FR 9632 - Fifth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held March 10, 2011, from...

  13. 76 FR 3931 - Fourth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 Meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held February 8, 2011...

  14. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  15. 78 FR 16757 - Twentieth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security... meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  16. 77 FR 64838 - Sixteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security... meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  17. 77 FR 55894 - Fifteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security... meeting of the RTCA Special Committee 224, Airport Security Access Control Systems DATES: The meeting will...

  18. 48 CFR 3452.224-72 - Research activities involving human subjects.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... involving human subjects. 3452.224-72 Section 3452.224-72 Federal Acquisition Regulations System DEPARTMENT... Text of Provisions and Clauses 3452.224-72 Research activities involving human subjects. As prescribed... human subjects covered under 34 CFR part 97: Research Activities Involving Human Subjects (MAR 2011) (a...

  19. 48 CFR 3452.224-72 - Research activities involving human subjects.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... involving human subjects. 3452.224-72 Section 3452.224-72 Federal Acquisition Regulations System DEPARTMENT... Text of Provisions and Clauses 3452.224-72 Research activities involving human subjects. As prescribed... human subjects covered under 34 CFR part 97: Research Activities Involving Human Subjects (MAR 2011) (a...

  20. 48 CFR 3452.224-72 - Research activities involving human subjects.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... involving human subjects. 3452.224-72 Section 3452.224-72 Federal Acquisition Regulations System DEPARTMENT... Text of Provisions and Clauses 3452.224-72 Research activities involving human subjects. As prescribed... human subjects covered under 34 CFR part 97: Research Activities Involving Human Subjects (MAR 2011) (a...

  1. 48 CFR 3452.224-72 - Research activities involving human subjects.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... involving human subjects. 3452.224-72 Section 3452.224-72 Federal Acquisition Regulations System DEPARTMENT... Text of Provisions and Clauses 3452.224-72 Research activities involving human subjects. As prescribed... human subjects covered under 34 CFR part 97: Research Activities Involving Human Subjects (MAR 2011) (a...

  2. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  3. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  4. 9 CFR 354.224 - Water supply.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Water supply. 354.224 Section 354.224....224 Water supply. The water supply shall be ample, clean, and potable with adequate facilities for its distribution in the plant and its protection against contamination and pollution. (a) Hot water at a...

  5. 78 FR 43963 - Twenty-Third Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Airport Security... meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  6. 22 CFR 224.22 - Exchange of witness lists, statements, and exhibits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Exchange of witness lists, statements, and exhibits. 224.22 Section 224.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.22 Exchange of witness lists, statements, and exhibits. (a...

  7. 22 CFR 224.22 - Exchange of witness lists, statements, and exhibits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exchange of witness lists, statements, and exhibits. 224.22 Section 224.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.22 Exchange of witness lists, statements, and exhibits. (a...

  8. 22 CFR 224.22 - Exchange of witness lists, statements, and exhibits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Exchange of witness lists, statements, and exhibits. 224.22 Section 224.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.22 Exchange of witness lists, statements, and exhibits. (a...

  9. 22 CFR 224.22 - Exchange of witness lists, statements, and exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exchange of witness lists, statements, and exhibits. 224.22 Section 224.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.22 Exchange of witness lists, statements, and exhibits. (a...

  10. 22 CFR 224.22 - Exchange of witness lists, statements, and exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exchange of witness lists, statements, and exhibits. 224.22 Section 224.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224.22 Exchange of witness lists, statements, and exhibits. (a...

  11. 75 FR 61819 - First Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems. DATES: The meeting will be held November 2, 2010...

  12. 49 CFR Appendix B to Part 224 - Reflectorization Implementation Compliance Report

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Reflectorization Implementation Compliance Report B Appendix B to Part 224 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK Pt. 224, App. B Appendix B to Part 224...

  13. 76 FR 16470 - Sixth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to... Committee 224: Airport Security Access Control Systems DATES: The meeting will be held April 13, 2011, from...

  14. 49 CFR 571.224 - Standard No. 224; Rear impact protection.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE SAFETY STANDARDS Federal Motor Vehicle Safety Standards § 571.224 Standard No. 224; Rear impact protection. S1. Scope. This... motor vehicle, as defined in 49 CFR 171.8, is certified to carry hazardous materials and has a rear...

  15. 49 CFR 571.224 - Standard No. 224; Rear impact protection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE SAFETY STANDARDS Federal Motor Vehicle Safety Standards § 571.224 Standard No. 224; Rear impact protection. S1. Scope. This... motor vehicle, as defined in 49 CFR 171.8, is certified to carry hazardous materials and has a rear...

  16. 49 CFR 571.224 - Standard No. 224; Rear impact protection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE SAFETY STANDARDS Federal Motor Vehicle Safety Standards § 571.224 Standard No. 224; Rear impact protection. S1. Scope. This... motor vehicle, as defined in 49 CFR 171.8, is certified to carry hazardous materials and has a rear...

  17. 49 CFR 224.11 - Penalties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Penalties. 224.11 Section 224.11 Transportation... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.11 Penalties. (a) Any person... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  18. 49 CFR 224.11 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Penalties. 224.11 Section 224.11 Transportation... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.11 Penalties. (a) Any person... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  19. 49 CFR 224.11 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Penalties. 224.11 Section 224.11 Transportation... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.11 Penalties. (a) Any person... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  20. 49 CFR 224.11 - Penalties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Penalties. 224.11 Section 224.11 Transportation... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.11 Penalties. (a) Any person... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  1. 49 CFR 224.11 - Penalties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Penalties. 224.11 Section 224.11 Transportation... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.11 Penalties. (a) Any person... requirement of this part or causes the violation of any such requirement is subject to a civil penalty of at...

  2. 29 CFR 553.224 - “Work period” defined.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âWork periodâ defined. 553.224 Section 553.224 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS APPLICATION... Enforcement Employees of Public Agencies Tour of Duty and Compensable Hours of Work Rules § 553.224 “Work...

  3. 25 CFR 224.171 - Who may rescind a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who may rescind a TERA? 224.171 Section 224.171 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Rescission § 224.171 Who may...

  4. 25 CFR 224.57 - What must the Director do upon receipt of an application?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...? 224.57 Section 224.57 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for Obtaining Tribal Energy Resource Agreements Processing Applications § 224.57 What must the...

  5. 25 CFR 224.65 - How may a tribe assume additional activities under a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...? 224.65 Section 224.65 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for Obtaining Tribal Energy Resource Agreements Tera Requirements § 224.65 How may a tribe assume...

  6. 25 CFR 224.74 - When must the Secretary approve or disapprove a final proposed TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... proposed TERA? 224.74 Section 224.74 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Approval of Tribal Energy Resource Agreements § 224.74 When must the Secretary approve or...

  7. 25 CFR 224.170 - What is the purpose of this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the purpose of this subpart? 224.170 Section 224.170 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Rescission § 224...

  8. 49 CFR Appendix C to Part 224 - Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports C Appendix C to Part 224 Transportation Other Regulations... REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK Pt. 224, App. C Appendix C to Part 224—Guidelines for Electronic...

  9. 25 CFR 224.171 - Who may rescind a TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who may rescind a TERA? 224.171 Section 224.171 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Rescission § 224.171 Who may...

  10. 25 CFR 224.170 - What is the purpose of this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the purpose of this subpart? 224.170 Section 224.170 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Rescission § 224...

  11. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  12. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  13. 76 FR 50498 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-15

    ... Pharmacies DEA Forms 224, 224a, 224b, 224c ACTION: 60-Day Notice of Information Collection under Review. The...; Affidavit for Chain Renewal; Application for Modification of Registration for Online Pharmacies. (3) Agency... substances must register with the DEA under the Controlled Substances Act. Pharmacies wishing to be online...

  14. 76 FR 64380 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... Pharmacies, DEA Forms 224, 224a, 224b, 224c ACTION: 30-Day Notice of Information Collection Under Review. The...; Affidavit for Chain Renewal; Application for Modification of Registration for Online Pharmacies. (3) Agency... register with the DEA under the Controlled Substances Act. Pharmacies wishing to be online pharmacies must...

  15. 77 FR 47095 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Pharmacies DEA Forms 224, 224a, 224b, 224c ACTION: 60-Day Notice of Information Collection Under Review. The...; Affidavit for Chain Renewal; Application for Modification of Registration for Online Pharmacies. (3) Agency... register with the DEA under the Controlled Substances Act. Pharmacies wishing to be online pharmacies must...

  16. 77 FR 62530 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... Pharmacies DEA Forms 224, 224a, 224b, 224c ACTION: 30-Day Notice. The Department of Justice (DOJ), Drug... Registration for Online Pharmacies. (3) Agency form number, if any, and the applicable component of the.... Pharmacies wishing to be online pharmacies must apply to modify their registrations. Such registration is...

  17. 25 CFR 224.135 - Under what circumstances may the Director conduct additional reviews and evaluations?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... harm to a physical trust asset, previously identified in a periodic review and evaluation, exists; or... additional reviews and evaluations? 224.135 Section 224.135 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews § 224.135 Under what circumstances may the Director...

  18. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  19. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appoint a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  20. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  1. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a bond without appointing a process agent? 224.3 Section 224.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation...

  2. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appoint a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  3. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a bond without appointing a process agent? 224.3 Section 224.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation...

  4. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  5. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  6. 22 CFR 22.4 - Requests for services, Foreign Service.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Requests for services, Foreign Service. 22.4 Section 22.4 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS SCHEDULE OF FEES FOR CONSULAR SERVICES-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.4 Requests for services, Foreign Service. Officers of the...

  7. 22 CFR 22.4 - Requests for services, Foreign Service.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Requests for services, Foreign Service. 22.4 Section 22.4 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS SCHEDULE OF FEES FOR CONSULAR SERVICES-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.4 Requests for services, Foreign Service. Officers of the...

  8. 22 CFR 22.4 - Requests for services, Foreign Service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Requests for services, Foreign Service. 22.4 Section 22.4 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS SCHEDULE OF FEES FOR CONSULAR SERVICES-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.4 Requests for services, Foreign Service. Officers of the...

  9. 22 CFR 22.4 - Requests for services, Foreign Service.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Requests for services, Foreign Service. 22.4 Section 22.4 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS SCHEDULE OF FEES FOR CONSULAR SERVICES-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.4 Requests for services, Foreign Service. Officers of the...

  10. 22 CFR 22.4 - Requests for services, Foreign Service.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Requests for services, Foreign Service. 22.4 Section 22.4 Foreign Relations DEPARTMENT OF STATE FEES AND FUNDS SCHEDULE OF FEES FOR CONSULAR SERVICES-DEPARTMENT OF STATE AND FOREIGN SERVICE § 22.4 Requests for services, Foreign Service. Officers of the...

  11. 49 CFR Appendix C to Part 224 - Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports C Appendix C to Part 224 Transportation Other Regulations... REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK Pt. 224, App. C Appendix C to Part 224—Guidelines for Electronic...

  12. 49 CFR Appendix C to Part 224 - Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports C Appendix C to Part 224 Transportation Other Regulations... REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK Pt. 224, App. C Appendix C to Part 224—Guidelines for Electronic...

  13. 76 FR 67019 - Tenth Meeting: RTCA Special Committee 224, Airport Security Access Control

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... 224, Airport Security Access Control AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 224, Airport Security Access Control. SUMMARY: The... (Pub. L. 92-463, 5 U.S.C., App.), notice is hereby given for a Special Committee 224, Airport Security...

  14. 49 CFR Appendix C to Part 224 - Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Guidelines for Electronic Submission of Reflectorization Implementation Compliance Reports C Appendix C to Part 224 Transportation Other Regulations... REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK Pt. 224, App. C Appendix C to Part 224—Guidelines for Electronic...

  15. Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

    PubMed Central

    Doñate, F; Juarez, J C; Burnett, M E; Manuia, M M; Guan, X; Shaw, D E; Smith, E L P; Timucin, C; Braunstein, M J; Batuman, O A; Mazar, A P

    2008-01-01

    Tetrathiomolybdate (choline salt; ATN-224), a specific, high-affinity copper binder, is currently being evaluated in several phase II cancer trials. ATN-224 inhibits CuZn superoxide dismutase 1 (SOD1) leading to antiangiogenic and antitumour effects. The pharmacodynamics of tetrathiomolybdate has been followed by tracking ceruloplasmin (Cp), a biomarker for systemic copper. However, at least in mice, the inhibition of angiogenesis occurs before a measurable decrease in systemic copper is observed. Thus, the identification and characterisation of other biomarkers to follow the activity of ATN-224 in the clinic is of great interest. Here, we present the preclinical evaluation of two potential biomarkers for the activity of ATN-224: (i) SOD activity measurements in blood cells in mice and (ii) levels of endothelial progenitor cells (EPCs) in bonnet macaques treated with ATN-224. The superoxide dismutase activity in blood cells in mice is rapidly inhibited by ATN-224 treatment at doses at which angiogenesis is maximally inhibited. Furthermore, ATN-224 dosing in bonnet macaques causes a profound and reversible decrease in EPCs without significant toxicity. Thus, both SOD activity measurements and levels of EPCs may be useful biomarkers of the antiangiogenic activity of ATN-224 to be used in its clinical development. PMID:18253124

  16. Alpha-emitting isotopes and chromium in a coastal California aquifer

    USGS Publications Warehouse

    Densmore, Jill N.; Izbicki, John A.; Murtaugh, Joseph M.; Swarzenski, Peter W.; Bullen, Thomas D.

    2014-01-01

    The unadjusted 72-h gross alpha activities in water from two wells completed in marine and alluvial deposits in a coastal southern California aquifer 40 km north of San Diego were 15 and 25 picoCuries per liter (pCi/L). Although activities were below the Maximum Contaminant Level (MCL) of 15 pCi/L, when adjusted for uranium activity; there is concern that new wells in the area may exceed MCLs, or that future regulations may limit water use from the wells. Coupled well-bore flow and depth-dependent water-quality data collected from the wells in 2011 (with analyses for isotopes within the uranium, actinium, and thorium decay-chains) show gross alpha activity in marine deposits is associated with decay of naturally-occurring 238U and its daughter 234U. Radon activities in marine deposits were as high as 2230 pCi/L. In contrast, gross alpha activities in overlying alluvium within the Piedra de Lumbre watershed, eroded from the nearby San Onofre Hills, were associated with decay of 232Th, including its daughter 224Ra. Radon activities in alluvium from Piedra de Lumbre of 450 pCi/L were lower than in marine deposits. Chromium VI concentrations in marine deposits were less than the California MCL of 10 μg/L (effective July 1, 2014) but δ53Cr compositions were near zero and within reported ranges for anthropogenic chromium. Alluvial deposits from the nearby Las Flores watershed, which drains a larger area having diverse geology, has low alpha activities and chromium as a result of geologic and geochemical conditions and may be more promising for future water-supply development.

  17. MicroRNA-224 inhibits proliferation and migration of breast cancer cells by down-regulating Fizzled 5 expression.

    PubMed

    Liu, Feng; Liu, Yang; Shen, Jingling; Zhang, Guoqiang; Han, Jiguang

    2016-08-02

    The Wnt/β-catenin signaling is crucial for the proliferation and migration of breast cancer cells. However, the expression of microRNA-224 (miR-224) in the different types of breast cancers and its role in the Wnt/β-catenin signaling and the proliferation and migration of breast cancer cells are poorly understood. In this study, the levels of miR-224 in different types of breast cancer tissues and cell lines were examined by quantitative RT-PCR and the potential targets of miR-224 in the Wnt/β-catenin signaling were investigated. The effects of altered miR-224 expression on the frequency of CD44+CD24- cancer stem-like cells (CSC), proliferation and migration of MCF-7 and MDA-MB-231 cells were examined by flow cytometry, MTT and transwell migration. We found that the levels of miR-224 expression in different types of breast cancer tissues and cell lines were associated inversely with aggressiveness of breast cancers. Enhanced miR-224 expression significantly reduced the fizzled 5-regulated luciferase activity in 293T cells, fizzled 5 expression in MCF-7 and MDA-MB-231 cells, the β-dependent luciferase activity in MCF-7 cells, and the nuclear translocation of β-catenin in MDA-MB-231 cells. miR-224 inhibition significantly increased the percentages of CSC in MCF-7 cells and enhanced proliferation and migration of MCF-7 cells. Enhanced miR-224 expression inhibited proliferation and migration of MDA-MB-231 cells, and the growth of implanted breast cancers in vivo. Induction of Frizzled 5 over-expression mitigated the miR-224-mediated inhibition of breast cancer cell proliferation. Collectively, these data indicated that miR-224 down-regulated the Wnt/β-catenin signaling possibly by binding to Frizzled 5 and inhibited proliferation and migration of breast cancer cells.

  18. 25 CFR 1000.224 - How can a Tribe/Consortium expedite the review of a regulation waiver request?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regulation waiver request? 1000.224 Section 1000.224 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.224 How can a...

  19. 77 FR 37732 - Fourteenth Meeting: RTCA Special Committee 224, Audio Systems and Equipment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... Committee 224, Audio Systems and Equipment AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 224, Audio Systems and Equipment. SUMMARY... Committee 224, Audio Systems and Equipment. DATES: The meeting will be held July 11, 2012, from 10 a.m.-4 p...

  20. 25 CFR 224.54 - How must a tribe submit an application?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How must a tribe submit an application? 224.54 Section 224... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

  1. 25 CFR 224.173 - How does a tribe rescind a TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does a tribe rescind a TERA? 224.173 Section 224.173 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Rescission § 224.173 How...

  2. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation provide a bond without appointing a process agent? A surety corporation may provide a bond without... a bond without appointing a process agent? 224.3 Section 224.3 Money and Finance: Treasury...

  3. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process...

  4. 29 CFR 553.224 - “Work period” defined.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false âWork periodâ defined. 553.224 Section 553.224 Labor... Enforcement Employees of Public Agencies Tour of Duty and Compensable Hours of Work Rules § 553.224 “Work period” defined. (a) As used in section 7(k), the term “work period” refers to any established and...

  5. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process...

  6. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process...

  7. 22 CFR 224.36 - Post-hearing briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Post-hearing briefs. 224.36 Section 224.36...

  8. 22 CFR 224.36 - Post-hearing briefs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Post-hearing briefs. 224.36 Section 224.36...

  9. 22 CFR 224.36 - Post-hearing briefs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Post-hearing briefs. 224.36 Section 224.36...

  10. 22 CFR 224.36 - Post-hearing briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Post-hearing briefs. 224.36 Section 224.36...

  11. 22 CFR 224.36 - Post-hearing briefs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ACT § 224.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event, any party may file a post-hearing brief. The ALJ shall fix the time for filing briefs, at a time... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Post-hearing briefs. 224.36 Section 224.36...

  12. 25 CFR 900.224 - What happens if the decision does not come within that time?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What happens if the decision does not come within that time? 900.224 Section 900.224 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN... EDUCATION ASSISTANCE ACT Post-Award Contract Disputes § 900.224 What happens if the decision does not come...

  13. 25 CFR 900.224 - What happens if the decision does not come within that time?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What happens if the decision does not come within that time? 900.224 Section 900.224 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN... EDUCATION ASSISTANCE ACT Post-Award Contract Disputes § 900.224 What happens if the decision does not come...

  14. 25 CFR 900.224 - What happens if the decision does not come within that time?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What happens if the decision does not come within that time? 900.224 Section 900.224 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN... EDUCATION ASSISTANCE ACT Post-Award Contract Disputes § 900.224 What happens if the decision does not come...

  15. 25 CFR 900.224 - What happens if the decision does not come within that time?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What happens if the decision does not come within that time? 900.224 Section 900.224 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN... EDUCATION ASSISTANCE ACT Post-Award Contract Disputes § 900.224 What happens if the decision does not come...

  16. 25 CFR 900.224 - What happens if the decision does not come within that time?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What happens if the decision does not come within that time? 900.224 Section 900.224 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR, AND INDIAN... EDUCATION ASSISTANCE ACT Post-Award Contract Disputes § 900.224 What happens if the decision does not come...

  17. 25 CFR 224.138 - What must the Director do if a tribe's noncompliance has caused imminent jeopardy to a physical...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... caused imminent jeopardy to a physical trust asset? 224.138 Section 224.138 Indians BUREAU OF INDIAN... TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.138 What must the Director do if a tribe's noncompliance has caused imminent jeopardy to a physical trust asset? If...

  18. 29 CFR 2.24 - Procedure in the event of an adverse ruling.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Procedure in the event of an adverse ruling. 2.24 Section 2.24 Labor Office of the Secretary of Labor GENERAL REGULATIONS Employees Served With Subpoenas § 2.24 Procedure in the event of an adverse ruling. If the court or other authority declines to stay the effect of...

  19. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money... FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process agent? A surety corporation may appoint either of the following as process agent—(a) An official of the...

  20. Fast Neutron Spectrum Potassium Worth for Space Power Reactor Design Validation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bess, John D.; Marshall, Margaret A.; Briggs, J. Blair

    2015-03-01

    A variety of critical experiments were constructed of enriched uranium metal (oralloy ) during the 1960s and 1970s at the Oak Ridge Critical Experiments Facility (ORCEF) in support of criticality safety operations at the Y-12 Plant. The purposes of these experiments included the evaluation of storage, casting, and handling limits for the Y-12 Plant and providing data for verification of calculation methods and cross-sections for nuclear criticality safety applications. These included solid cylinders of various diameters, annuli of various inner and outer diameters, two and three interacting cylinders of various diameters, and graphite and polyethylene reflected cylinders and annuli. Ofmore » the hundreds of delayed critical experiments, one was performed that consisted of uranium metal annuli surrounding a potassium-filled, stainless steel can. The outer diameter of the annuli was approximately 13 inches (33.02 cm) with an inner diameter of 7 inches (17.78 cm). The diameter of the stainless steel can was 7 inches (17.78 cm). The critical height of the configurations was approximately 5.6 inches (14.224 cm). The uranium annulus consisted of multiple stacked rings, each with radial thicknesses of 1 inch (2.54 cm) and varying heights. A companion measurement was performed using empty stainless steel cans; the primary purpose of these experiments was to test the fast neutron cross sections of potassium as it was a candidate for coolant in some early space power reactor designs.The experimental measurements were performed on July 11, 1963, by J. T. Mihalczo and M. S. Wyatt (Ref. 1) with additional information in its corresponding logbook. Unreflected and unmoderated experiments with the same set of highly enriched uranium metal parts were performed at the Oak Ridge Critical Experiments Facility in the 1960s and are evaluated in the International Handbook for Evaluated Criticality Safety Benchmark Experiments (ICSBEP Handbook) with the identifier HEU MET FAST 051. Thin graphite reflected (2 inches or less) experiments also using the same set of highly enriched uranium metal parts are evaluated in HEU MET FAST 071. Polyethylene-reflected configurations are evaluated in HEU-MET-FAST-076. A stack of highly enriched metal discs with a thick beryllium top reflector is evaluated in HEU-MET-FAST-069, and two additional highly enriched uranium annuli with beryllium cores are evaluated in HEU-MET-FAST-059. Both detailed and simplified model specifications are provided in this evaluation. Both of these fast neutron spectra assemblies were determined to be acceptable benchmark experiments. The calculated eigenvalues for both the detailed and the simple benchmark models are within ~0.26 % of the benchmark values for Configuration 1 (calculations performed using MCNP6 with ENDF/B-VII.1 neutron cross section data), but under-calculate the benchmark values by ~7s because the uncertainty in the benchmark is very small: ~0.0004 (1s); for Configuration 2, the under-calculation is ~0.31 % and ~8s. Comparison of detailed and simple model calculations for the potassium worth measurement and potassium mass coefficient yield results approximately 70 – 80 % lower (~6s to 10s) than the benchmark values for the various nuclear data libraries utilized. Both the potassium worth and mass coefficient are also deemed to be acceptable benchmark experiment measurements.« less

  1. 25 CFR 224.139 - What must a tribe do after receiving a notice of imminent jeopardy to a physical trust asset?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... jeopardy to a physical trust asset? 224.139 Section 224.139 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF... DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.139 What must a tribe do after receiving a notice of imminent jeopardy to a physical trust asset? (a) Upon receipt of a notice of imminent...

  2. 25 CFR 224.40 - How does the Act or a TERA affect the Secretary's trust responsibility?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does the Act or a TERA affect the Secretary's trust responsibility? 224.40 Section 224.40 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General Provisions § 224.40...

  3. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  4. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  5. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  6. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews Noncompliance § 224.137 What must the Director do if a tribe's noncompliance has resulted in harm or the...

  7. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats.

    PubMed

    Qiu, Yanyan; Zhang, Yanan; Li, Jun-Xu

    2015-02-15

    Although imidazoline I2 receptor ligands have been used as discriminative stimuli, the role of efficacy of I2 receptor ligands as a critical determinant in drug discrimination has not been explored. This study characterized the discriminative stimulus effects of selective imidazoline I2 receptor ligands BU224 (a low-efficacy I2 receptor ligand) and phenyzoline (a higher efficacy I2 receptor ligand) in rats. Two groups of male Sprague-Dawley rats were trained to discriminate 5.6mg/kg BU224 or 32mg/kg phenyzoline (i.p.) from their vehicle in a two-lever food-reinforced drug discrimination procedure, respectively. All rats acquired the discriminations after an average of 18 (BU224) and 56 (phenyzoline) training sessions, respectively. BU224 and phenyzoline completely substituted for one another symmetrically. Several I2 receptor ligands (tracizoline, CR4056, RS45041, and idazoxan) all occasioned>80% drug-associated lever responding in both discriminations. The I2 receptor ligand 2-BFI and a monoamine oxidase inhibitor harmane occasioned>80% drug-associated lever responding in rats discriminating BU224. Other drugs that occasioned partial or less substitution to BU224 cue included clonidine, methamphetamine, ketamine, morphine, methadone and agmatine. Clonidine, methamphetamine and morphine also only produced partial substitution to phenyzoline cue. Naltrexone, dopamine D2 receptor antagonist haloperidol and serotonin (5-HT)2A receptor antagonist MDL100907 failed to alter the discriminative stimulus effects of BU224 or phenyzoline. Combined, these results are the first to demonstrate that BU224 and phenyzoline can serve as discriminative stimuli and that the low-efficacy I2 receptor ligand BU224 shares similar discriminative stimulus effects with higher-efficacy I2 receptor ligands such as phenyzoline and 2-BFI. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms' tumor gene 1 (WT1) protein.

    PubMed

    Montano, Giorgia; Ullmark, Tove; Jernmark-Nilsson, Helena; Sodaro, Gaetano; Drott, Kristina; Costanzo, Paola; Vidovic, Karina; Gullberg, Urban

    2016-01-01

    The transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter. The zinc finger protein ZNF224 can act as a transcriptional co-factor of WT1 and potentiate the cytotoxic response to the cytostatic drug cytarabine. We hypothesized that cytarabine upregulates IRF8 and that transcriptional control of IRF8 involves WT1 and ZNF224. Treatment of leukemic K562 cells with cytarabine upregulated IRF8 protein and mRNA, which was correlated to increased expression of ZNF224. Knock down of ZNF224 with shRNA suppressed both basal and cytarabine-induced IRF8 expression. While ZNF224 alone did not affect IRF8 promoter activity, ZNF224 partially reversed the suppressive effect of WT1 on the IRF8 promoter, as judged by luciferase reporter experiments. Coprecipitation revealed nuclear binding of WT1 and ZNF224, and by chromatin immunoprecipitation (ChIP) experiments it was demonstrated that WT1 recruits ZNF224 to the IRF8 promoter. We conclude that cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224, which can counteract the repressive activity of WT1 on the IRF8-promoter. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.

    PubMed

    Guo, Xing; Xue, Hao; Guo, Xiaofan; Gao, Xiao; Xu, Shugang; Yan, Shaofeng; Han, Xiao; Li, Tong; Shen, Jie; Li, Gang

    2015-12-08

    Human glioblastoma multiforme (GBM) is a malignant solid tumor characterized by severe hypoxia. Autophagy plays a protective role in cancer cells under hypoxia. However, the microRNA (miRNA)-related molecular mechanisms underlying hypoxia-reduced autophagy remain poorly understood in GBM. In this study, we performed a miRNA microarray analysis on GBM cells and found that numerous miRNAs were differentially expressed under hypoxic conditions. Further research showed that miR224-3p, one of the significantly down-regulated miRNAs, was involved in regulating hypoxia-induced autophagy in GBM cells. Overexpression of miR224-3p abolished hypoxia-induced autophagy, whereas knocking down endogenous miR224-3p increased autophagic activity under normoxia. In addition, we demonstrated that miR224-3p inhibited autophagy by directly suppressing the expression of two autophagy-related genes (ATGs), ATG5 and FAK family-interacting protein of 200 kDa (FIP200). Furthermore, in vitro, miR224-3p attenuated cell proliferation and promoted hypoxia-induced apoptosis, and in vivo, overexpression of miR224-3p inhibited tumorigenesis of GBM cells. Collectively, our study identified a novel hypoxia-down-regulated miRNA, miR224-3p, as a key modulator of autophagy by inhibiting ATGs in GBM cells.

  10. Tachykinin antagonist FK224 inhibits neurokinin A-, substance P- and capsaicin-induced human bronchial contraction.

    PubMed

    Honda, I; Kohrogi, H; Yamaguchi, T; Hamamoto, J; Hirata, N; Iwagoe, H; Fujii, K; Goto, E; Ando, M

    1997-01-01

    To determine the roles of endogenously released tachykinins (substance P [SP] and neurokinin A [NKA]) in the human bronchial tissues, we studied the effects of tachykinin antagonist FK224 on bronchial smooth muscle contraction induced by SP, NKA and capsaicin in an organ bath. FK224 (10(-6) M and 10(-5) M, respectively) significantly inhibited NKA-induced contraction and 10(-5) M FK224 shifted the dose-response curve to more than one log unit higher concentration. Because SP- and capsaicin-induced contractions were small, we pretreated the tissues with the neutral endopeptidase inhibitor phosphoramidon (10(-5) M), which inhibits degradation of exogenous tachykinins in order to potentiate the contractions. FK224 (10(-5) M) significantly inhibited SP-induced contraction and it shifted the dose-response curves to about one log unit higher concentration. FK224 (10(-5) M) also significantly inhibited capsaicin-induced contraction and it shifted the dose-response curves to more than one log unit higher concentration. In contrast, FK224 (10(-5) M) did not affect on acetylcholine-, histamine-, and leukotriene D4-induced contraction. These results suggest that FK224 is a tachykinin receptor antagonist in the human bronchial smooth muscle, and that capsaicin-induced contraction is due to endogenously released tachykinin-like substances in the human bronchus.

  11. 20 CFR 10.224 - What happens if OWCP finds that the employee is not entitled to COP after it has been paid?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... is not entitled to COP after it has been paid? 10.224 Section 10.224 Employees' Benefits OFFICE OF... Termination of Cop § 10.224 What happens if OWCP finds that the employee is not entitled to COP after it has been paid? Where OWCP finds that the employee is not entitled to COP after it has been paid, the...

  12. 20 CFR 10.224 - What happens if OWCP finds that the employee is not entitled to COP after it has been paid?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... is not entitled to COP after it has been paid? 10.224 Section 10.224 Employees' Benefits OFFICE OF... Termination of Cop § 10.224 What happens if OWCP finds that the employee is not entitled to COP after it has been paid? Where OWCP finds that the employee is not entitled to COP after it has been paid, the...

  13. 20 CFR 10.224 - What happens if OWCP finds that the employee is not entitled to COP after it has been paid?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... is not entitled to COP after it has been paid? 10.224 Section 10.224 Employees' Benefits OFFICE OF... Termination of Cop § 10.224 What happens if OWCP finds that the employee is not entitled to COP after it has been paid? Where OWCP finds that the employee is not entitled to COP after it has been paid, the...

  14. 20 CFR 10.224 - What happens if OWCP finds that the employee is not entitled to COP after it has been paid?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... is not entitled to COP after it has been paid? 10.224 Section 10.224 Employees' Benefits OFFICE OF... Termination of Cop § 10.224 What happens if OWCP finds that the employee is not entitled to COP after it has been paid? Where OWCP finds that the employee is not entitled to COP after it has been paid, the...

  15. 20 CFR 10.224 - What happens if OWCP finds that the employee is not entitled to COP after it has been paid?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... is not entitled to COP after it has been paid? 10.224 Section 10.224 Employees' Benefits OFFICE OF... Termination of Cop § 10.224 What happens if OWCP finds that the employee is not entitled to COP after it has been paid? Where OWCP finds that the employee is not entitled to COP after it has been paid, the...

  16. 40 CFR 61.224 - Recordkeeping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Recordkeeping requirements. 61.224 Section 61.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standards for Radon...

  17. 40 CFR 61.224 - Recordkeeping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 8 2011-07-01 2011-07-01 false Recordkeeping requirements. 61.224 Section 61.224 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standards for Radon...

  18. 25 CFR 224.59 - How will the Director use the results of the application consultation meeting?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF... information provided through §§ 224.53 and 224.63 to determine the energy resource development capacity of the...

  19. 49 CFR 384.224 - Noncommercial motor vehicle violations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Noncommercial motor vehicle violations. 384.224 Section 384.224 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS STATE...

  20. 49 CFR 384.224 - Noncommercial motor vehicle violations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Noncommercial motor vehicle violations. 384.224 Section 384.224 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS STATE...

  1. 50 CFR 217.224 - Mitigation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Mitigation. 217.224 Section 217.224 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS REGULATIONS GOVERNING THE TAKE OF MARINE MAMMALS INCIDENTAL TO...

  2. Analysis Of 2H-Evaporator Scale Pot Bottom Sample [HTF-13-11-28H

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oji, L. N.

    2013-07-15

    Savannah River Remediation (SRR) is planning to remove a buildup of sodium aluminosilicate scale from the 2H-evaporator pot by loading and soaking the pot with heated 1.5 M nitric acid solution. Sampling and analysis of the scale material from the 2H evaporator has been performed so that the evaporator can be chemically cleaned beginning July of 2013. Historically, since the operation of the Defense Waste Processing Facility (DWPF), silicon in the DWPF recycle stream combines with aluminum in the typical tank farm supernate to form sodium aluminosilicate scale mineral deposits in the 2H-evaporator pot and gravity drain line. The 2H-evaporatormore » scale samples analyzed by Savannah River National Laboratory (SRNL) came from the bottom cone sections of the 2H-evaporator pot. The sample holder from the 2H-evaporator wall was virtually empty and was not included in the analysis. It is worth noting that after the delivery of these 2H-evaporator scale samples to SRNL for the analyses, the plant customer determined that the 2H evaporator could be operated for additional period prior to requiring cleaning. Therefore, there was no need for expedited sample analysis as was presented in the Technical Task Request. However, a second set of 2H evaporator scale samples were expected in May of 2013, which would need expedited sample analysis. X-ray diffraction analysis (XRD) confirmed the bottom cone section sample from the 2H-evaporator pot consisted of nitrated cancrinite, (a crystalline sodium aluminosilicate solid), clarkeite and uranium oxide. There were also mercury compound XRD peaks which could not be matched and further X-ray fluorescence (XRF) analysis of the sample confirmed the existence of elemental mercury or mercuric oxide. On ''as received'' basis, the scale contained an average of 7.09E+00 wt % total uranium (n = 3; st.dev. = 8.31E-01 wt %) with a U-235 enrichment of 5.80E-01 % (n = 3; st.dev. = 3.96E-02 %). The measured U-238 concentration was 7.05E+00 wt % (n=3, st. dev. = 8.25E-01 wt %). Analyses results for Pu-238 and Pu-239, and Pu-241 are 7.06E-05 {+-} 7.63E-06 wt %, 9.45E-04 {+-} 3.52E-05 wt %, and <2.24E-06 wt %, respectively. These results are provided so that SRR can calculate the equivalent uranium-235 concentrations for the NCSA. Because this 2H evaporator pot bottom scale sample contained a significant amount of elemental mercury (11.7 wt % average), it is recommended that analysis for mercury be included in future Technical Task Requests on 2H evaporator sample analysis at SRNL. Results confirm that the uranium contained in the scale remains depleted with respect to natural uranium. SRNL did not calculate an equivalent U-235 enrichment, which takes into account other fissionable isotopes U-233, Pu-239 and Pu-241.« less

  3. Polybrominated diphenyl ethers with potent and broad spectrum antimicrobial activity from the marine sponge Dysidea.

    PubMed

    Sun, Shi; Canning, Corene B; Bhargava, Kanika; Sun, Xiuxiu; Zhu, Wenjun; Zhou, Ninghui; Zhang, Yifan; Zhou, Kequan

    2015-01-01

    Three polybrominated diphenyl ethers, 2-(2',4'-dibromophenoxy)-3,5-dibromophenol (1) and 2-(2',4'-dibromophenoxy)-3,4,5-tribromophenol (2) were isolated from the marine sponge Dysidea granulosa; and 2-(2',4'-dibromophenoxy)-4,6-dibromophenol (3) from Dysidea spp. They exhibited potent and broad spectrum in vitro antibacterial activity, especially against methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Escherichia coli O157:H7, and Salmonella. Minimal inhibitory concentration (MIC) was evaluated against 12 clinical and standard strains of Gram positive and negative bacteria. The observed MIC range was 0.1-4.0mg/L against all the Gram positive bacteria and 0.1-16.0mg/L against Gram negative bacteria. 2-(2',4″-Dibromophenoxy)-3,5-dibromophenol showed stronger broad spectrum antibacterial activity than other two compounds. 2-(2',4″-Dibromophenoxy)-3,5-dibromophenol and 2-(2',4'-dibromophenoxy)-4,6-dibromophenol are thermo-stable. The results suggest that 2-(2',4'-dibromophenoxy)-3,5-dibromophenol could be used as a potential lead molecule for anti-MRSA, anti-E. coli O157:H7, and anti-Salmonella for drug development. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. 42 CFR 438.224 - Confidentiality.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Confidentiality. 438.224 Section 438.224 Public...) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Quality Assessment and Performance Improvement Structure and... enrollment information that identifies a particular enrollee, each MCO, PIHP, and PAHP uses and discloses...

  5. 42 CFR 438.224 - Confidentiality.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Confidentiality. 438.224 Section 438.224 Public...) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Quality Assessment and Performance Improvement Structure and... enrollment information that identifies a particular enrollee, each MCO, PIHP, and PAHP uses and discloses...

  6. 42 CFR 438.224 - Confidentiality.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Confidentiality. 438.224 Section 438.224 Public...) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Quality Assessment and Performance Improvement Structure and... enrollment information that identifies a particular enrollee, each MCO, PIHP, and PAHP uses and discloses...

  7. 48 CFR 1652.224-70 - Confidentiality of records.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Confidentiality of records. 1652.224-70 Section 1652.224-70 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES HEALTH BENEFITS ACQUISITION REGULATION CLAUSES AND FORMS CONTRACT CLAUSES Texts of FEHBP...

  8. 49 CFR 224.13 - Preemptive effect.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Preemptive effect. 224.13 Section 224.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... effect. Under 49 U.S.C. 20106, issuance of this part preempts any State law, rule, regulation, or order...

  9. 40 CFR 264.224-264.225 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false [Reserved] 264.224-264.225 Section 264.224-264.225 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE, AND DISPOSAL FACILITIES...

  10. 22 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... limited to any advantage, preference, privilege, license, permit, favorable decision, ruling, status, or... United States Government. Individual means a natural person. Initial decision means the written decision of the ALJ required by § 224.10 or § 224.37, and includes a revised initial decision issued following...

  11. Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents.

    PubMed

    Kosowska-Shick, Klaudia; Credito, Kim; Pankuch, Glenn A; Lin, Gengrong; Bozdogan, Bülent; McGhee, Pamela; Dewasse, Bonifacio; Choi, Dong-Rack; Ryu, Jei Man; Appelbaum, Peter C

    2006-06-01

    DW-224a is a new broad-spectrum quinolone with excellent antipneumococcal activity. Agar dilution MIC was used to test the activity of DW-224a compared to those of penicillin, ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin, gemifloxacin, amoxicillin-clavulanate, cefuroxime, and azithromycin against 353 quinolone-susceptible pneumococci. The MICs of 29 quinolone-resistant pneumococci with defined quinolone resistance mechanisms against seven quinolones and an efflux mechanism were also tested. DW-224a was the most potent quinolone against quinolone-susceptible pneumococci (MIC(50), 0.016 microg/ml; MIC(90), 0.03 microg/ml), followed by gemifloxacin, moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin. beta-Lactam MICs rose with those of penicillin G, and azithromycin resistance was seen mainly in strains with raised penicillin G MICs. Against the 29 quinolone-resistant strains, DW-224a had the lowest MICs (0.06 to 1 microg/ml) compared to those of gemifloxacin, clinafloxacin, moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin. DW-224a at 2x MIC was bactericidal after 24 h against eight of nine strains tested. Other quinolones gave similar kill kinetics relative to higher MICs. Serial passages of nine strains in the presence of sub-MIC concentrations of DW-224a, moxifloxacin, levofloxacin, ciprofloxacin, gatifloxacin, gemifloxacin, amoxicillin-clavulanate, cefuroxime, and azithromycin were performed. DW-224a yielded resistant clones similar to moxifloxacin and gemifloxacin but also yielded lower MICs. Azithromycin selected resistant clones in three of the five parents tested. Amoxicillin-clavulanate and cefuroxime did not yield resistant clones after 50 days.

  12. 25 CFR 224.81 - What laws are applicable to activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 224.81 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Implementation of Tribal Energy Resource Agreements Applicable Authorities and Responsibilities § 224.81 What laws are...

  13. 30 CFR 285.224 - What happens if MMS accepts my bid?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 285.224 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 285.224 What...

  14. 36 CFR 223.224 - Performance bonds and security.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Performance bonds and security. 223.224 Section 223.224 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER, SPECIAL FOREST PRODUCTS, AND FOREST BOTANICAL...

  15. 76 FR 59481 - Ninth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Control Systems (Update to DO-230B): Agenda October 20, 2011 Welcome/Introductions/Administrative Remarks... 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems. SUMMARY...

  16. 76 FR 50811 - Eighth Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... Control Systems (Update to DO-230B): Agenda September 15, 2011 Welcome/Introductions/Administrative... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems. SUMMARY...

  17. 50 CFR 224.102 - Permits for endangered marine and anadromous species.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Permits for endangered marine and anadromous species. 224.102 Section 224.102 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS ENDANGERED MARINE...

  18. 50 CFR 224.102 - Permits for endangered marine and anadromous species.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Permits for endangered marine and anadromous species. 224.102 Section 224.102 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS ENDANGERED MARINE...

  19. 37 CFR 1.122-1.224 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false [Reserved] 1.122-1.224 Section 1.122-1.224 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES National Processing Provisions Amendments...

  20. 27 CFR 41.224 - Transfer of ownership.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Transfer of ownership. 41.224 Section 41.224 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS AND TUBES...

  1. 27 CFR 41.224 - Transfer of ownership.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Transfer of ownership. 41.224 Section 41.224 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO IMPORTATION OF TOBACCO PRODUCTS, CIGARETTE PAPERS AND TUBES...

  2. 18 CFR 2.24 - Project decommissioning at relicensing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Project decommissioning at relicensing. 2.24 Section 2.24 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Statements of General...

  3. 18 CFR 2.24 - Project decommissioning at relicensing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Project decommissioning at relicensing. 2.24 Section 2.24 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Statements of General...

  4. 18 CFR 2.24 - Project decommissioning at relicensing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Project decommissioning at relicensing. 2.24 Section 2.24 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Statements of General...

  5. 18 CFR 2.24 - Project decommissioning at relicensing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Project decommissioning at relicensing. 2.24 Section 2.24 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Statements of General...

  6. 25 CFR 224.182 - What is the Initial Appeal Process?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the Initial Appeal Process? 224.182 Section 224.182 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General Appeal...

  7. 25 CFR 224.183 - What other administrative appeals processes also apply?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What other administrative appeals processes also apply? 224.183 Section 224.183 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  8. 25 CFR 224.103 - Must a tribe establish other public participation processes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Must a tribe establish other public participation processes? 224.103 Section 224.103 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  9. 25 CFR 224.68 - How will the Secretary use public comments?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 224.68 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for Obtaining Tribal Energy Resource Agreements Public Notification and Comment § 224.68 How will...

  10. 25 CFR 224.184 - How do other administrative appeals processes apply?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How do other administrative appeals processes apply? 224.184 Section 224.184 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  11. 25 CFR 224.182 - What is the Initial Appeal Process?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the Initial Appeal Process? 224.182 Section 224.182 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General Appeal...

  12. 25 CFR 224.160 - How will reassumption affect a TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will reassumption affect a TERA? 224.160 Section 224.160 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Reassumption...

  13. 25 CFR 224.184 - How do other administrative appeals processes apply?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How do other administrative appeals processes apply? 224.184 Section 224.184 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  14. 25 CFR 224.101 - Who is an interested party?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who is an interested party? 224.101 Section 224.101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Interested Party Petitions...

  15. 25 CFR 224.151 - When may the Secretary reassume activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When may the Secretary reassume activities? 224.151 Section 224.151 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  16. 25 CFR 224.160 - How will reassumption affect a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How will reassumption affect a TERA? 224.160 Section 224.160 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Reassumption...

  17. 25 CFR 224.174 - When does a voluntary rescission become effective?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When does a voluntary rescission become effective? 224.174 Section 224.174 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  18. 25 CFR 224.62 - May a final proposed TERA differ from the original proposed TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... proposed TERA? 224.62 Section 224.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for Obtaining Tribal Energy Resource Agreements Application Consultation Meeting...

  19. 25 CFR 224.183 - What other administrative appeals processes also apply?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What other administrative appeals processes also apply? 224.183 Section 224.183 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  20. 14 CFR 417.224 - Probability of failure analysis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Probability of failure analysis. 417.224 Section 417.224 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... phase of normal flight or when any anomalous condition exhibits the potential for a stage or its debris...

  1. 14 CFR 417.224 - Probability of failure analysis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Probability of failure analysis. 417.224 Section 417.224 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... phase of normal flight or when any anomalous condition exhibits the potential for a stage or its debris...

  2. 14 CFR 417.224 - Probability of failure analysis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Probability of failure analysis. 417.224 Section 417.224 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... phase of normal flight or when any anomalous condition exhibits the potential for a stage or its debris...

  3. 14 CFR 417.224 - Probability of failure analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Probability of failure analysis. 417.224 Section 417.224 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... phase of normal flight or when any anomalous condition exhibits the potential for a stage or its debris...

  4. 25 CFR 224.81 - What laws are applicable to activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What laws are applicable to activities? 224.81 Section 224.81 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Implementation of...

  5. 25 CFR 224.68 - How will the Secretary use public comments?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Secretary use public comments? 224.68 Section 224.68 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  6. 25 CFR 224.58 - What is an application consultation meeting?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is an application consultation meeting? 224.58 Section 224.58 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  7. 25 CFR 224.103 - Must a tribe establish other public participation processes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Must a tribe establish other public participation processes? 224.103 Section 224.103 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  8. 25 CFR 224.101 - Who is an interested party?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who is an interested party? 224.101 Section 224.101 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Interested Party Petitions...

  9. 25 CFR 224.80 - Under what authority will a tribe perform activities for energy resource development?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... energy resource development? 224.80 Section 224.80 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Implementation of Tribal Energy Resource Agreements Applicable Authorities...

  10. 25 CFR 224.174 - When does a voluntary rescission become effective?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When does a voluntary rescission become effective? 224.174 Section 224.174 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  11. 76 FR 38742 - Seventh Meeting: RTCA Special Committee 224: Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ... Control Systems (Update to DO-230B): Agenda July 15, 2011 Welcome/Introductions/Administrative Remarks... Committee 224: Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special Committee 224 meeting: Airport Security Access Control Systems (Update to...

  12. 22 CFR 224.44 - Right to administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Right to administrative offset. 224.44 Section 224.44 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD... against a refund of an overpayment of Federal taxes, then or later owning by the United States to the...

  13. 12 CFR 303.224-303.239 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false [Reserved] 303.224-303.239 Section 303.224-303.239 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE FILING PROCEDURES Section 19 of the FDI Act (Consent to Service of Persons Convicted of Certain Criminal Offenses...

  14. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code...

  15. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States Code...

  16. 22 CFR 224.21 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  17. 37 CFR 42.224 - Discovery.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Discovery. 42.224 Section 42... Post-Grant Review § 42.224 Discovery. Notwithstanding the discovery provisions of subpart A: (a) Requests for additional discovery may be granted upon a showing of good cause as to why the discovery is...

  18. 37 CFR 42.224 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Discovery. 42.224 Section 42... Post-Grant Review § 42.224 Discovery. Notwithstanding the discovery provisions of subpart A: (a) Requests for additional discovery may be granted upon a showing of good cause as to why the discovery is...

  19. 22 CFR 224.21 - Discovery.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  20. 22 CFR 224.21 - Discovery.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  1. 22 CFR 224.21 - Discovery.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  2. 22 CFR 224.21 - Discovery.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...

  3. 48 CFR 52.224-2 - Privacy Act.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Privacy Act. 52.224-2... AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 52.224-2 Privacy... agency function: Privacy Act (APR 1984) (a) The Contractor agrees to— (1) Comply with the Privacy Act of...

  4. 14 CFR 417.224 - Probability of failure analysis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Probability of failure analysis. 417.224 Section 417.224 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION... phase of normal flight or when any anomalous condition exhibits the potential for a stage or its debris...

  5. 50 CFR 224.103 - Special prohibitions for endangered marine mammals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... marine mammals. 224.103 Section 224.103 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... approach is authorized by the National Marine Fisheries Service through a permit issued under part 222... section do not apply if a right whale approach is authorized by the National Marine Fisheries Service...

  6. 18 CFR 284.224 - Certain transportation and sales by local distribution companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Certain transportation and sales by local distribution companies. 284.224 Section 284.224 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY OTHER REGULATIONS UNDER THE NATURAL GAS...

  7. Antipneumococcal Activity of DW-224a, a New Quinolone, Compared to Those of Eight Other Agents

    PubMed Central

    Kosowska-Shick, Klaudia; Credito, Kim; Pankuch, Glenn A.; Lin, Gengrong; Bozdogan, Bülent; McGhee, Pamela; Dewasse, Bonifacio; Choi, Dong-Rack; Ryu, Jei Man; Appelbaum, Peter C.

    2006-01-01

    DW-224a is a new broad-spectrum quinolone with excellent antipneumococcal activity. Agar dilution MIC was used to test the activity of DW-224a compared to those of penicillin, ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin, gemifloxacin, amoxicillin-clavulanate, cefuroxime, and azithromycin against 353 quinolone-susceptible pneumococci. The MICs of 29 quinolone-resistant pneumococci with defined quinolone resistance mechanisms against seven quinolones and an efflux mechanism were also tested. DW-224a was the most potent quinolone against quinolone-susceptible pneumococci (MIC50, 0.016 μg/ml; MIC90, 0.03 μg/ml), followed by gemifloxacin, moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin. β-Lactam MICs rose with those of penicillin G, and azithromycin resistance was seen mainly in strains with raised penicillin G MICs. Against the 29 quinolone-resistant strains, DW-224a had the lowest MICs (0.06 to 1 μg/ml) compared to those of gemifloxacin, clinafloxacin, moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin. DW-224a at 2× MIC was bactericidal after 24 h against eight of nine strains tested. Other quinolones gave similar kill kinetics relative to higher MICs. Serial passages of nine strains in the presence of sub-MIC concentrations of DW-224a, moxifloxacin, levofloxacin, ciprofloxacin, gatifloxacin, gemifloxacin, amoxicillin-clavulanate, cefuroxime, and azithromycin were performed. DW-224a yielded resistant clones similar to moxifloxacin and gemifloxacin but also yielded lower MICs. Azithromycin selected resistant clones in three of the five parents tested. Amoxicillin-clavulanate and cefuroxime did not yield resistant clones after 50 days. PMID:16723567

  8. 25 CFR 224.180 - What is the purpose of this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the purpose of this subpart? 224.180 Section 224.180 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General Appeal...

  9. 25 CFR 224.42 - How does the Paperwork Reduction Act affect these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does the Paperwork Reduction Act affect these regulations? 224.42 Section 224.42 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  10. 25 CFR 224.66 - How may a tribe reduce the scope of the TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 224.66 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for Obtaining Tribal Energy Resource Agreements Tera Requirements § 224.66 How may a tribe reduce...

  11. 25 CFR 224.111 - When may a petitioner file a petition with the Secretary?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When may a petitioner file a petition with the Secretary? 224.111 Section 224.111 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  12. 25 CFR 224.157 - How must the Secretary proceed after receiving the tribe's response?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How must the Secretary proceed after receiving the tribe's response? 224.157 Section 224.157 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  13. 25 CFR 224.185 - When are decisions under this part effective?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When are decisions under this part effective? 224.185 Section 224.185 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General...

  14. 25 CFR 224.154 - What must a notice of intent to reassume include?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must a notice of intent to reassume include? 224.154 Section 224.154 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  15. 25 CFR 224.80 - Under what authority will a tribe perform activities for energy resource development?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... energy resource development? 224.80 Section 224.80 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT... development? A tribe will perform activities for energy resource development activities undertaken under a...

  16. 25 CFR 224.130 - What is the purpose of this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the purpose of this subpart? 224.130 Section 224.130 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews...

  17. 25 CFR 224.150 - What is the purpose of this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the purpose of this subpart? 224.150 Section 224.150 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Reassumption...

  18. 25 CFR 224.108 - May tribes offer a resolution of a petitioner's claim?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false May tribes offer a resolution of a petitioner's claim? 224.108 Section 224.108 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  19. 25 CFR 224.181 - Who may appeal Departmental decisions or inaction under this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Who may appeal Departmental decisions or inaction under this part? 224.181 Section 224.181 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  20. 25 CFR 224.154 - What must a notice of intent to reassume include?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must a notice of intent to reassume include? 224.154 Section 224.154 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  1. 25 CFR 224.185 - When are decisions under this part effective?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When are decisions under this part effective? 224.185 Section 224.185 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General...

  2. 25 CFR 224.110 - What must a petition to the Secretary contain?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must a petition to the Secretary contain? 224.110 Section 224.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  3. 25 CFR 224.180 - What is the purpose of this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What is the purpose of this subpart? 224.180 Section 224.180 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General Appeal...

  4. 25 CFR 224.181 - Who may appeal Departmental decisions or inaction under this part?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Who may appeal Departmental decisions or inaction under this part? 224.181 Section 224.181 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  5. 25 CFR 224.130 - What is the purpose of this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the purpose of this subpart? 224.130 Section 224.130 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews...

  6. 25 CFR 224.157 - How must the Secretary proceed after receiving the tribe's response?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How must the Secretary proceed after receiving the tribe's response? 224.157 Section 224.157 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  7. 25 CFR 224.132 - How does the Director conduct a periodic review and evaluation?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does the Director conduct a periodic review and evaluation? 224.132 Section 224.132 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  8. 30 CFR 585.224 - What happens if BOEM accepts my bid?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 585.224 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 585.224 What happens if BOEM accepts my bid? If we...

  9. 30 CFR 585.224 - What happens if BOEM accepts my bid?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 585.224 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 585.224 What happens if BOEM accepts my bid? If we...

  10. 30 CFR 585.224 - What happens if BOEM accepts my bid?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 585.224 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 585.224 What happens if BOEM accepts my bid? If we...

  11. 25 CFR 224.151 - When may the Secretary reassume activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Reassumption § 224.151 When may the Secretary reassume activities? Upon issuing a written finding of imminent jeopardy to a physical trust asset, the Secretary may reassume activities under a TERA in accordance with... 25 Indians 1 2010-04-01 2010-04-01 false When may the Secretary reassume activities? 224.151...

  12. 25 CFR 224.110 - What must a petition to the Secretary contain?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must a petition to the Secretary contain? 224.110 Section 224.110 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  13. 25 CFR 224.150 - What is the purpose of this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the purpose of this subpart? 224.150 Section 224.150 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Reassumption...

  14. 25 CFR 224.42 - How does the Paperwork Reduction Act affect these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How does the Paperwork Reduction Act affect these regulations? 224.42 Section 224.42 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  15. 25 CFR 224.111 - When may a petitioner file a petition with the Secretary?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When may a petitioner file a petition with the Secretary? 224.111 Section 224.111 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  16. 25 CFR 224.108 - May tribes offer a resolution of a petitioner's claim?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false May tribes offer a resolution of a petitioner's claim? 224.108 Section 224.108 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  17. 25 CFR 224.50 - What is the purpose of this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the purpose of this subpart? 224.50 Section 224.50 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for...

  18. 25 CFR 224.54 - How must a tribe submit an application?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How must a tribe submit an application? 224.54 Section 224.54 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Procedures for...

  19. 77 FR 71474 - Seventeenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S... Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the seventeenth meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  20. 78 FR 31627 - Twenty-Second Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S... Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty-second meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  1. 78 FR 7850 - Nineteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S... Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the nineteenth meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  2. 77 FR 2343 - Eleventh Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S... Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the eleventh meeting of RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting will be held...

  3. 78 FR 22025 - Twenty First Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S... Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twenty first meeting of the RTCA Special Committee 224, Airport Security Access Control Systems. DATES: The meeting...

  4. 77 FR 25525 - Thirteenth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... Committee 224, Airport Security Access Control Systems. AGENCY: Federal Aviation Administration (FAA), U.S... Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the thirteenth meeting of RTCA Special Committee 224, Airport Security Access Control Systems DATES: The meeting will be...

  5. 77 FR 15448 - Twelfth Meeting: RTCA Special Committee 224, Airport Security Access Control Systems

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... Committee 224, Airport Security Access Control Systems AGENCY: Federal Aviation Administration (FAA), U.S... Access Control Systems. SUMMARY: The FAA is issuing this notice to advise the public of the twelfth meeting of RTCA Special Committee 224, Airport Security Access Control Systems DATES: The meeting will be...

  6. 4 CFR 22.4 - Appeal File [Rule 4].

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... contracting officer relied in making the decision, and any correspondence relating thereto; (v) Transcripts of... 4 Accounts 1 2010-01-01 2010-01-01 false Appeal File [Rule 4]. 22.4 Section 22.4 Accounts... consisting of all documents pertinent to the appeal, including: (i) The decision from which the appeal is...

  7. 40 CFR 86.224-94 - Carbon dioxide analyzer calibration.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Carbon dioxide analyzer calibration. 86.224-94 Section 86.224-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NEW AND IN-USE HIGHWAY VEHICLES AND ENGINES Emission Regulations for 1994 and Later Model Year...

  8. 21 CFR 1301.13 - Application for registration; time for application; expiration date; registration for independent...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the business activity is registered. (d) At the time a retail pharmacy, hospital/clinic, practitioner..., Hospital/Clinic, Retail Pharmacy, Online Pharmacy, Central fill pharmacy, Teaching Institution) Schedules II-V New—224Renewal—224a Online Pharmacy—224c 551551 3 May conduct research and instructional...

  9. 49 CFR Appendix A to Part 224 - Schedule of Civil Penalties1

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 4 2012-10-01 2012-10-01 false Schedule of Civil Penalties1 A Appendix A to Part 224 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Appendix A to Part 224—Schedule of Civil Penalties1 Subpart B—Application, Inspection, and Maintenance of...

  10. 31 CFR 540.317 - Uranium feed; natural uranium feed.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Uranium feed; natural uranium feed...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.317 Uranium feed; natural uranium feed. The term uranium feed or natural uranium feed means natural uranium in the form of UF6 suitable for uranium...

  11. 31 CFR 540.317 - Uranium feed; natural uranium feed.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Uranium feed; natural uranium feed...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.317 Uranium feed; natural uranium feed. The term uranium feed or natural uranium feed means natural uranium in the form of UF6 suitable for uranium...

  12. Process for continuous production of metallic uranium and uranium alloys

    DOEpatents

    Hayden, H.W. Jr.; Horton, J.A.; Elliott, G.R.B.

    1995-06-06

    A method is described for forming metallic uranium, or a uranium alloy, from uranium oxide in a manner which substantially eliminates the formation of uranium-containing wastes. A source of uranium dioxide is first provided, for example, by reducing uranium trioxide (UO{sub 3}), or any other substantially stable uranium oxide, to form the uranium dioxide (UO{sub 2}). This uranium dioxide is then chlorinated to form uranium tetrachloride (UCl{sub 4}), and the uranium tetrachloride is then reduced to metallic uranium by reacting the uranium chloride with a metal which will form the chloride of the metal. This last step may be carried out in the presence of another metal capable of forming one or more alloys with metallic uranium to thereby lower the melting point of the reduced uranium product. The metal chloride formed during the uranium tetrachloride reduction step may then be reduced in an electrolysis cell to recover and recycle the metal back to the uranium tetrachloride reduction operation and the chlorine gas back to the uranium dioxide chlorination operation. 4 figs.

  13. Process for continuous production of metallic uranium and uranium alloys

    DOEpatents

    Hayden, Jr., Howard W.; Horton, James A.; Elliott, Guy R. B.

    1995-01-01

    A method is described for forming metallic uranium, or a uranium alloy, from uranium oxide in a manner which substantially eliminates the formation of uranium-containing wastes. A source of uranium dioxide is first provided, for example, by reducing uranium trioxide (UO.sub.3), or any other substantially stable uranium oxide, to form the uranium dioxide (UO.sub.2). This uranium dioxide is then chlorinated to form uranium tetrachloride (UCl.sub.4), and the uranium tetrachloride is then reduced to metallic uranium by reacting the uranium chloride with a metal which will form the chloride of the metal. This last step may be carried out in the presence of another metal capable of forming one or more alloys with metallic uranium to thereby lower the melting point of the reduced uranium product. The metal chloride formed during the uranium tetrachloride reduction step may then be reduced in an electrolysis cell to recover and recycle the metal back to the uranium tetrachloride reduction operation and the chlorine gas back to the uranium dioxide chlorination operation.

  14. MiR-224 Targets the 3′UTR of Type 1 5′-Iodothyronine Deiodinase Possibly Contributing to Tissue Hypothyroidism in Renal Cancer

    PubMed Central

    Boguslawska, Joanna; Wojcicka, Anna; Piekielko-Witkowska, Agnieszka; Master, Adam; Nauman, Alicja

    2011-01-01

    Type 1 iodothyronine deiodinase (DIO1) catalyses the conversion of prohormone thyroxine to the active thyroid hormone 3,3′,5-triiodothyronine (T3), important regulator of cell proliferation and differentiation. DIO1 expression is reduced in the most common type of kidney neoplasia, clear cell Renal Cell Carcinoma (ccRCC). MicroRNAs are small, non-coding RNAs that regulate gene expression at posttranscriptional levels. The aim of this study was to analyze the potential regulation of DIO1 expression by microRNAs in ccRCC. Bioinformatic analysis revealed that 3′UTR of the human DIO1 gene transcript contains miR-224 and miR-383 target sites, which are conserved across mammalian species. Semi-quantitative real-time PCR was used to analyze the expression of miR-224 and miR-383 in 32 samples of ccRCC tumors (T) and in 32 matched control (C) samples. We observed statistically significant (p = 0.0002) more than four fold increase in miR-224 expression and nearly two fold increase in miR-383 expression in samples T compared to samples C. Tumor specific changes in expression of miR-224 negatively correlated with changes in DIO1 expression and intracellular T3 concentration. Transfection of HeLa cell line with miR-224 and miR-383 suppressed the activity of a luciferase reporter containing the 3′UTR of DIO1. This was abolished when constructs mutated at the miR-224 and miR-383 target sites were used instead, indicating that miR-224 and miR-383 directly bind to DIO1 3′UTR. Finally, induced expression of miR-224 in Caki-2 cells resulted in significant (p<0.01) reduction of DIO1 mRNA. This study provides a novel miRNA-mediated regulatory mechanism of DIO1 expression in ccRCC. PMID:21912701

  15. MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.

    PubMed

    Boguslawska, Joanna; Wojcicka, Anna; Piekielko-Witkowska, Agnieszka; Master, Adam; Nauman, Alicja

    2011-01-01

    Type 1 iodothyronine deiodinase (DIO1) catalyses the conversion of prohormone thyroxine to the active thyroid hormone 3,3',5-triiodothyronine (T3), important regulator of cell proliferation and differentiation. DIO1 expression is reduced in the most common type of kidney neoplasia, clear cell Renal Cell Carcinoma (ccRCC). MicroRNAs are small, non-coding RNAs that regulate gene expression at posttranscriptional levels. The aim of this study was to analyze the potential regulation of DIO1 expression by microRNAs in ccRCC. Bioinformatic analysis revealed that 3'UTR of the human DIO1 gene transcript contains miR-224 and miR-383 target sites, which are conserved across mammalian species. Semi-quantitative real-time PCR was used to analyze the expression of miR-224 and miR-383 in 32 samples of ccRCC tumors (T) and in 32 matched control (C) samples. We observed statistically significant (p = 0.0002) more than four fold increase in miR-224 expression and nearly two fold increase in miR-383 expression in samples T compared to samples C. Tumor specific changes in expression of miR-224 negatively correlated with changes in DIO1 expression and intracellular T3 concentration. Transfection of HeLa cell line with miR-224 and miR-383 suppressed the activity of a luciferase reporter containing the 3'UTR of DIO1. This was abolished when constructs mutated at the miR-224 and miR-383 target sites were used instead, indicating that miR-224 and miR-383 directly bind to DIO1 3'UTR. Finally, induced expression of miR-224 in Caki-2 cells resulted in significant (p<0.01) reduction of DIO1 mRNA. This study provides a novel miRNA-mediated regulatory mechanism of DIO1 expression in ccRCC.

  16. Method for converting uranium oxides to uranium metal

    DOEpatents

    Duerksen, Walter K.

    1988-01-01

    A process is described for converting scrap and waste uranium oxide to uranium metal. The uranium oxide is sequentially reduced with a suitable reducing agent to a mixture of uranium metal and oxide products. The uranium metal is then converted to uranium hydride and the uranium hydride-containing mixture is then cooled to a temperature less than -100.degree. C. in an inert liquid which renders the uranium hydride ferromagnetic. The uranium hydride is then magnetically separated from the cooled mixture. The separated uranium hydride is readily converted to uranium metal by heating in an inert atmosphere. This process is environmentally acceptable and eliminates the use of hydrogen fluoride as well as the explosive conditions encountered in the previously employed bomb-reduction processes utilized for converting uranium oxides to uranium metal.

  17. 25 CFR 224.107 - What must a petitioner do before filing a petition with the Secretary?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must a petitioner do before filing a petition with the Secretary? 224.107 Section 224.107 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  18. 25 CFR 224.120 - What action may the Director take to ensure compliance with a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What action may the Director take to ensure compliance with a TERA? 224.120 Section 224.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  19. 25 CFR 224.133 - What must the Director do after a periodic review and evaluation?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must the Director do after a periodic review and evaluation? 224.133 Section 224.133 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  20. 25 CFR 224.134 - How often must the Director conduct a periodic review and evaluation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How often must the Director conduct a periodic review and evaluation? 224.134 Section 224.134 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  1. 25 CFR 224.134 - How often must the Director conduct a periodic review and evaluation?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How often must the Director conduct a periodic review and evaluation? 224.134 Section 224.134 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  2. 25 CFR 224.119 - What must the Director do when making a decision on a petition?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must the Director do when making a decision on a petition? 224.119 Section 224.119 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  3. 25 CFR 224.113 - What must the tribe do after it completes petition consultation with the Director?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must the tribe do after it completes petition consultation with the Director? 224.113 Section 224.113 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT...

  4. 25 CFR 224.112 - What must the Director do upon receipt of a petition?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must the Director do upon receipt of a petition? 224.112 Section 224.112 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  5. 25 CFR 224.114 - How may the tribe address a petition in its written response?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How may the tribe address a petition in its written response? 224.114 Section 224.114 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  6. 25 CFR 224.155 - When must a tribe respond to a notice of intent to reassume?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When must a tribe respond to a notice of intent to reassume? 224.155 Section 224.155 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  7. 25 CFR 224.133 - What must the Director do after a periodic review and evaluation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must the Director do after a periodic review and evaluation? 224.133 Section 224.133 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  8. 25 CFR 224.158 - What must the Secretary include in a written notice of reassumption?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must the Secretary include in a written notice of reassumption? 224.158 Section 224.158 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  9. 25 CFR 224.155 - When must a tribe respond to a notice of intent to reassume?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When must a tribe respond to a notice of intent to reassume? 224.155 Section 224.155 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  10. 25 CFR 224.158 - What must the Secretary include in a written notice of reassumption?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must the Secretary include in a written notice of reassumption? 224.158 Section 224.158 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  11. 25 CFR 224.40 - How does the Act or a TERA affect the Secretary's trust responsibility?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does the Act or a TERA affect the Secretary's trust responsibility? 224.40 Section 224.40 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  12. 25 CFR 224.54 - How must a tribe submit an application?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How must a tribe submit an application? 224.54 Section... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

  13. 25 CFR 224.54 - How must a tribe submit an application?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How must a tribe submit an application? 224.54 Section... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

  14. 25 CFR 224.54 - How must a tribe submit an application?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How must a tribe submit an application? 224.54 Section... Obtaining Tribal Energy Resource Agreements Processing Applications § 224.54 How must a tribe submit an application? A tribe must submit an application and all supporting documents in written and electronic form to...

  15. 25 CFR 224.57 - What must the Director do upon receipt of an application?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must the Director do upon receipt of an application? 224.57 Section 224.57 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  16. 25 CFR 224.107 - What must a petitioner do before filing a petition with the Secretary?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must a petitioner do before filing a petition with the Secretary? 224.107 Section 224.107 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  17. 25 CFR 224.114 - How may the tribe address a petition in its written response?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How may the tribe address a petition in its written response? 224.114 Section 224.114 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  18. 25 CFR 224.74 - When must the Secretary approve or disapprove a final proposed TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false When must the Secretary approve or disapprove a final proposed TERA? 224.74 Section 224.74 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  19. 25 CFR 224.120 - What action may the Director take to ensure compliance with a TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What action may the Director take to ensure compliance with a TERA? 224.120 Section 224.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  20. 25 CFR 224.62 - May a final proposed TERA differ from the original proposed TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false May a final proposed TERA differ from the original proposed TERA? 224.62 Section 224.62 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  1. 25 CFR 224.112 - What must the Director do upon receipt of a petition?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What must the Director do upon receipt of a petition? 224.112 Section 224.112 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT...

  2. 50 CFR 224.104 - Special requirements for fishing activities to protect endangered sea turtles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... activities to protect endangered sea turtles. 224.104 Section 224.104 Wildlife and Fisheries NATIONAL MARINE... endangered sea turtles. (a) Shrimp fishermen in the southeastern United States and the Gulf of Mexico who comply with rules for threatened sea turtles specified in § 223.206 of this chapter will not be subject...

  3. 50 CFR 224.104 - Special requirements for fishing activities to protect endangered sea turtles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... activities to protect endangered sea turtles. 224.104 Section 224.104 Wildlife and Fisheries NATIONAL MARINE... endangered sea turtles. (a) Shrimp fishermen in the southeastern United States and the Gulf of Mexico who comply with rules for threatened sea turtles specified in § 223.206 of this chapter will not be subject...

  4. 31 CFR 224.6 - Where can I find a sample power of attorney form?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Where can I find a sample power of attorney form? 224.6 Section 224.6 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF...

  5. 76 FR 40817 - Implementation of Section 224 of the Act; A National Broadband Plan for Our Future

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-12

    ...-50] Implementation of Section 224 of the Act; A National Broadband Plan for Our Future AGENCY... information collection requirements. The Office of Management and Budget (OMB) gave approval for these..., Implementation of Section 224 of the Act; A National Broadband Plan for Our Future. DATES: The final rules...

  6. 31 CFR 224.6 - Where can I find a sample power of attorney form?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Where can I find a sample power of attorney form? 224.6 Section 224.6 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF...

  7. 31 CFR 224.6 - Where can I find a sample power of attorney form?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Where can I find a sample power of attorney form? 224.6 Section 224.6 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF...

  8. 30 CFR 250.224 - What information on support vessels, offshore vehicles, and aircraft you will use must accompany...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false What information on support vessels, offshore vehicles, and aircraft you will use must accompany the EP? 250.224 Section 250.224 Mineral Resources BUREAU... GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Contents of...

  9. 22 CFR 224.26 - Form, filing and service of papers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Form, filing and service of papers. 224.26... CIVIL REMEDIES ACT § 224.26 Form, filing and service of papers. (a) Form. (1) Documents filed with the ALJ shall include an original and two copies. (2) Every pleading and paper filed in the proceeding...

  10. 22 CFR 224.26 - Form, filing and service of papers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Form, filing and service of papers. 224.26... CIVIL REMEDIES ACT § 224.26 Form, filing and service of papers. (a) Form. (1) Documents filed with the ALJ shall include an original and two copies. (2) Every pleading and paper filed in the proceeding...

  11. 49 CFR Table 1 to Subpart B of... - Minimum Coefficient of Retroreflection (RA) (in Candela/Lux/Meter2) Requirement for...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) 1 Table 1 to Subpart B of Part 224 Transportation Other Regulations Relating to Transportation... ROLLING STOCK Application, Inspection, and Maintenance of Retroreflective Material Pt. 224, Subpt. B, Table 1 Table 1 to Subpart B of Part 224—Minimum Coefficient of Retroreflection (RA) (in Candela/Lux...

  12. 49 CFR Table 1 to Subpart B of... - Minimum Coefficient of Retroreflection (RA) (in Candela/Lux/Meter2) Requirement for...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) 1 Table 1 to Subpart B of Part 224 Transportation Other Regulations Relating to Transportation... ROLLING STOCK Application, Inspection, and Maintenance of Retroreflective Material Pt. 224, Subpt. B, Table 1 Table 1 to Subpart B of Part 224—Minimum Coefficient of Retroreflection (RA) (in Candela/Lux...

  13. 10 CFR 431.224 - Uniform test method for the measurement of energy consumption for traffic signal modules and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Uniform test method for the measurement of energy consumption for traffic signal modules and pedestrian modules. 431.224 Section 431.224 Energy DEPARTMENT OF... measurement of energy consumption for traffic signal modules and pedestrian modules. (a) Scope. This section...

  14. Investigation of distribution of radioactivity with effects of heavy metals in toothpastes from Penang markets.

    PubMed

    Salih, Najeba F; Jafri, Zubir M; Jaafar, Mohamad S

    2016-12-01

    This study was carried out to determine the concentration of 222 Rn, 226 Ra, and 238 U in 25 different toothpastes available in the local market in Penang, Malaysia, using a CR-39 detector. The results showed the maximum concentration of radon/ radium/uranium to be 4197.644 Bq.m -3 , 54.369 Bq.Kgm -1 , and 0.044 ppm in Colgate4; the annual effective dose was found (0.402 mSvy -1 ) in S07. The average concentration of radon (42 %, 3.224 KBq.m -3 ) was higher than the concentration of 214 Po, 218 Po in POS (32 %, 2.415 KBq.m -3 ) and POW (26 %, 1.979 KBq.m -3 ). Also the values of pH of samples ranged from 4.21 (highly acidic) in S04 to 9.97 (highly basic) in S07, with an average of 6.33 which tended towards an acidic behavior; a low or high pH for a long period of time can cause harmful side-effects and enamel erosion. Concentrations of heavy metals varied from the maximum value 56.156 ppm in the Ca elements in the Colgate 4 sample to a minimum value of -0.858 ppm in the Cd elements in Colgate 6 (Ca 56.156 ppm > Cd 51.572 ppm > Zn 41.039 ppm > Mg 11.682 ppm > Pb 11.009 ppm]. Monitoring the accumulation of these metals in toothpaste samples is very important: the average annual effective dose (0.3118 mSvy -1 ) was below the range (3-10 mSvy -1 ) reported by ICRP (1993), and therefore there is no evidence of health problems. Significant strong positive correlations were found (r = 1, Pearson correlation, p < 0.000) in concentration of radon, radium, uranium, annual effective dose, pH, and electrical conductivity.

  15. MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise

    PubMed Central

    Bacon, Siobhán; Engelbrecht, Britta; Schmid, Jasmin; Pfeiffer, Shona; Gallagher, Ross; McCarthy, Ailbhe; Burke, Marie; Concannon, Caoimhín; Prehn, Jochen H. M.; Byrne, Maria M.

    2015-01-01

    MicroRNA (miRNA) are a class of non-coding, 19–25 nucleotide RNA critical for network-level regulation of gene expression. miRNA serve as paracrine signaling molecules. Using an unbiased array approach, we previously identified elevated levels of miR-224 and miR-103 to be associated with a monogenic form of diabetes; HNF1A-MODY. miR-224 is a novel miRNA in the field of diabetes. We sought to explore the role of miR-224 as a potential biomarker in diabetes, and whether such diabetes-associated-miRNA can also be detected in the urine of patients. Absolute levels of miR-224 and miR-103 were determined in the urine of n = 144 individuals including carriers of a HNF1A mutation, participants with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM) and normal controls. Expression levels were correlated with clinical and biochemical parameters. miR-224 was significantly elevated in the urine of carriers of a HNF1A mutation and participants with T1DM. miR-103 was highly expressed in urine across all diabetes cohorts when compared to controls. For both miR-224 and-103, we found a significant correlation between serum and urine levels (p < 0.01). We demonstrate that miRNA can be readily detected in the urine independent of clinical indices of renal dysfunction. We surmise that the differential expression levels of miR-224 in both HNF1A-MODY mutation carriers and T1DM may be an attempt to compensate for beta-cell demise. PMID:26110317

  16. 25 CFR 224.153 - Must the Secretary notify the tribe of an intent to reassume the authority granted?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Must the Secretary notify the tribe of an intent to reassume the authority granted? 224.153 Section 224.153 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT...

  17. 25 CFR 224.109 - What must a petitioner claim or request in a petition filed with the Secretary?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must a petitioner claim or request in a petition filed with the Secretary? 224.109 Section 224.109 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT...

  18. 25 CFR 224.41 - When does the Secretary require agreement of more than one tribe to approve a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false When does the Secretary require agreement of more than one tribe to approve a TERA? 224.41 Section 224.41 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT...

  19. 25 CFR 224.141 - What must the Secretary do if the tribe responds to the Director's order?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false What must the Secretary do if the tribe responds to the Director's order? 224.141 Section 224.141 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  20. 25 CFR 224.117 - Must the Director make a determination of the tribe's compliance with a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Must the Director make a determination of the tribe's compliance with a TERA? 224.117 Section 224.117 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  1. 25 CFR 224.153 - Must the Secretary notify the tribe of an intent to reassume the authority granted?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Must the Secretary notify the tribe of an intent to reassume the authority granted? 224.153 Section 224.153 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT...

  2. 41 CFR 302-3.224 - If I violate my new service agreement, will the Government reimburse me for return travel and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false If I violate my new... place of residence? 302-3.224 Section 302-3.224 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  3. 41 CFR 302-3.224 - If I violate my new service agreement, will the Government reimburse me for return travel and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false If I violate my new... place of residence? 302-3.224 Section 302-3.224 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  4. 41 CFR 302-3.224 - If I violate my new service agreement, will the Government reimburse me for return travel and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false If I violate my new... place of residence? 302-3.224 Section 302-3.224 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  5. 41 CFR 302-3.224 - If I violate my new service agreement, will the Government reimburse me for return travel and...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false If I violate my new... place of residence? 302-3.224 Section 302-3.224 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  6. 41 CFR 302-3.224 - If I violate my new service agreement, will the Government reimburse me for return travel and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true If I violate my new... place of residence? 302-3.224 Section 302-3.224 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES RELOCATION ALLOWANCES 3-RELOCATION ALLOWANCE BY SPECIFIC TYPE Types...

  7. 25 CFR 224.173 - How does a tribe rescind a TERA?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true How does a tribe rescind a TERA? 224.173 Section 224.173... does a tribe rescind a TERA? To rescind a TERA, a tribe must submit to the Secretary a written tribal resolution or other official action of the tribe's governing body approving the voluntary rescission of the...

  8. 25 CFR 224.173 - How does a tribe rescind a TERA?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false How does a tribe rescind a TERA? 224.173 Section 224.173... does a tribe rescind a TERA? To rescind a TERA, a tribe must submit to the Secretary a written tribal resolution or other official action of the tribe's governing body approving the voluntary rescission of the...

  9. 25 CFR 224.173 - How does a tribe rescind a TERA?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false How does a tribe rescind a TERA? 224.173 Section 224.173... does a tribe rescind a TERA? To rescind a TERA, a tribe must submit to the Secretary a written tribal resolution or other official action of the tribe's governing body approving the voluntary rescission of the...

  10. 25 CFR 224.173 - How does a tribe rescind a TERA?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false How does a tribe rescind a TERA? 224.173 Section 224.173... does a tribe rescind a TERA? To rescind a TERA, a tribe must submit to the Secretary a written tribal resolution or other official action of the tribe's governing body approving the voluntary rescission of the...

  11. 25 CFR 224.117 - Must the Director make a determination of the tribe's compliance with a TERA?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Must the Director make a determination of the tribe's compliance with a TERA? 224.117 Section 224.117 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  12. 25 CFR 224.56 - What is the effect of the Director's receipt of a tribe's complete application?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What is the effect of the Director's receipt of a tribe's complete application? 224.56 Section 224.56 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  13. 25 CFR 224.87 - What are the obligations of a tribe if it discovers a violation or breach?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What are the obligations of a tribe if it discovers a violation or breach? 224.87 Section 224.87 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS TRIBAL ENERGY RESOURCE AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF...

  14. 78 FR 17874 - Hazardous Materials: Miscellaneous Petitions for Rulemaking (RRR)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-25

    ... II 4.1 53 151 224 None Forbidden Forbidden D 52, 53 liquid type B. * * * * * * * G......... Self-reactive 4.1 UN3223 II 4.1 151 224 None 5 L 10 L D 52, 53 liquid type C. * * * * * * * G......... Self...-reactive 4.1 UN3222 II 4.1 53 151 224 None Forbidden Forbidden D 52, 53 solid type B. * * * * * * * G...

  15. 25 CFR 224.137 - What must the Director do if a tribe's noncompliance has resulted in harm or the potential for...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... resulted in harm or the potential for harm to a physical trust asset? 224.137 Section 224.137 Indians... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT Periodic Reviews... potential for harm to a physical trust asset? If, because of the tribe's noncompliance with Federal law or...

  16. 49 CFR Table 1 of Subpart B to... - Minimum Coefficient of Retroreflection (RA) (in Candela/Lux/Meter2) Requirement for...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) 1 Table 1 of Subpart B to Part 224 Transportation Other Regulations Relating to Transportation... ROLLING STOCK Pt. 224, Subpt. B, Table 1 Table 1 of Subpart B to Part 224—Minimum Coefficient of... Performance Requirements) Entrance angle Observation angle 0.2 Degree Yellow or fluorescent yellow White 0.5...

  17. 49 CFR Table 1 of Subpart B to... - Minimum Coefficient of Retroreflection (RA) (in Candela/Lux/Meter2) Requirement for...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) 1 Table 1 of Subpart B to Part 224 Transportation Other Regulations Relating to Transportation... ROLLING STOCK Pt. 224, Subpt. B, Table 1 Table 1 of Subpart B to Part 224—Minimum Coefficient of... Performance Requirements) Entrance angle Observation angle 0.2 Degree Yellow or fluorescent yellow White 0.5...

  18. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1.

    PubMed

    Juarez, Jose C; Betancourt, Oscar; Pirie-Shepherd, Steven R; Guan, Xiaojun; Price, Melissa L; Shaw, David E; Mazar, Andrew P; Doñate, Fernando

    2006-08-15

    A second-generation tetrathiomolybdate analogue (ATN-224; choline tetrathiomolybdate), which selectively binds copper with high affinity, is currently completing two phase I clinical trials in patients with advanced solid and advanced hematologic malignancies. However, there is very little information about the mechanism of action of ATN-224 at the molecular level. The effects of ATN-224 on endothelial and tumor cell growth were evaluated in cell culture experiments in vitro. The antiangiogenic activity of ATN-224 was investigated using the Matrigel plug model of angiogenesis. ATN-224 inhibits superoxide dismutase 1 (SOD1) in tumor and endothelial cells. The inhibition of SOD1 leads to inhibition of endothelial cell proliferation in vitro and attenuation of angiogenesis in vivo. The inhibition of SOD1 activity in endothelial cells is dose and time dependent and leads to an increase in the steady-state levels of superoxide anions, resulting in the inhibition of extracellular signal-regulated kinase phosphorylation without apparent induction of apoptosis. In contrast, the inhibition of SOD1 in tumor cells leads to the induction of apoptosis. The effects of ATN-224 on endothelial and tumor cells could be substantially reversed using Mn(III)tetrakis(4-benzoic acid)porphyrin chloride, a catalytic small-molecule SOD mimetic. These data provide a distinct molecular target for the activity of ATN-224 and provide validation for SOD1 as a target for the inhibition of angiogenesis and tumor growth.

  19. 40 CFR 421.320 - Applicability: Description of the secondary uranium subcategory.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... secondary uranium subcategory. 421.320 Section 421.320 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Secondary Uranium Subcategory § 421.320 Applicability: Description of the secondary uranium... uranium (including depleted uranium) by secondary uranium facilities. ...

  20. 40 CFR 421.320 - Applicability: Description of the secondary uranium subcategory.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... secondary uranium subcategory. 421.320 Section 421.320 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Secondary Uranium Subcategory § 421.320 Applicability: Description of the secondary uranium... uranium (including depleted uranium) by secondary uranium facilities. ...

  1. 40 CFR 421.320 - Applicability: Description of the secondary uranium subcategory.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... secondary uranium subcategory. 421.320 Section 421.320 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Secondary Uranium Subcategory § 421.320 Applicability: Description of the secondary uranium... uranium (including depleted uranium) by secondary uranium facilities. ...

  2. 40 CFR 421.320 - Applicability: Description of the secondary uranium subcategory.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... secondary uranium subcategory. 421.320 Section 421.320 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Secondary Uranium Subcategory § 421.320 Applicability: Description of the secondary uranium... uranium (including depleted uranium) by secondary uranium facilities. ...

  3. 40 CFR 421.320 - Applicability: Description of the secondary uranium subcategory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... secondary uranium subcategory. 421.320 Section 421.320 Protection of Environment ENVIRONMENTAL PROTECTION... CATEGORY Secondary Uranium Subcategory § 421.320 Applicability: Description of the secondary uranium... uranium (including depleted uranium) by secondary uranium facilities. ...

  4. Bioremediation of uranium contamination with enzymatic uranium reduction

    USGS Publications Warehouse

    Lovley, D.R.; Phillips, E.J.P.

    1992-01-01

    Enzymatic uranium reduction by Desulfovibrio desulfuricans readily removed uranium from solution in a batch system or when D. desulfuricans was separated from the bulk of the uranium-containing water by a semipermeable membrane. Uranium reduction continued at concentrations as high as 24 mM. Of a variety of potentially inhibiting anions and metals evaluated, only high concentrations of copper inhibited uranium reduction. Freeze-dried cells, stored aerobically, reduced uranium as fast as fresh cells. D. desulfuricans reduced uranium in pH 4 and pH 7.4 mine drainage waters and in uraniumcontaining groundwaters from a contaminated Department of Energy site. Enzymatic uranium reduction has several potential advantages over other bioprocessing techniques for uranium removal, the most important of which are as follows: the ability to precipitate uranium that is in the form of a uranyl carbonate complex; high capacity for uranium removal per cell; the formation of a compact, relatively pure, uranium precipitate.

  5. Release behavior of uranium in uranium mill tailings under environmental conditions.

    PubMed

    Liu, Bo; Peng, Tongjiang; Sun, Hongjuan; Yue, Huanjuan

    2017-05-01

    Uranium contamination is observed in sedimentary geochemical environments, but the geochemical and mineralogical processes that control uranium release from sediment are not fully appreciated. Identification of how sediments and water influence the release and migration of uranium is critical to improve the prevention of uranium contamination in soil and groundwater. To understand the process of uranium release and migration from uranium mill tailings under water chemistry conditions, uranium mill tailing samples from northwest China were investigated with batch leaching experiments. Results showed that water played an important role in uranium release from the tailing minerals. The uranium release was clearly influenced by contact time, liquid-solid ratio, particle size, and pH under water chemistry conditions. Longer contact time, higher liquid content, and extreme pH were all not conducive to the stabilization of uranium and accelerated the uranium release from the tailing mineral to the solution. The values of pH were found to significantly influence the extent and mechanisms of uranium release from minerals to water. Uranium release was monitored by a number of interactive processes, including dissolution of uranium-bearing minerals, uranium desorption from mineral surfaces, and formation of aqueous uranium complexes. Considering the impact of contact time, liquid-solid ratio, particle size, and pH on uranium release from uranium mill tailings, reducing the water content, decreasing the porosity of tailing dumps and controlling the pH of tailings were the key factors for prevention and management of environmental pollution in areas near uranium mines. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. 25 CFR 224.152 - Must the Secretary always reassume the activities upon a finding of imminent jeopardy to a...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... reassume the activities upon a finding of imminent jeopardy to a physical trust asset? (a) The Secretary... 25 Indians 1 2011-04-01 2011-04-01 false Must the Secretary always reassume the activities upon a finding of imminent jeopardy to a physical trust asset? 224.152 Section 224.152 Indians BUREAU OF INDIAN...

  7. 25 CFR 224.152 - Must the Secretary always reassume the activities upon a finding of imminent jeopardy to a...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... reassume the activities upon a finding of imminent jeopardy to a physical trust asset? (a) The Secretary... 25 Indians 1 2010-04-01 2010-04-01 false Must the Secretary always reassume the activities upon a finding of imminent jeopardy to a physical trust asset? 224.152 Section 224.152 Indians BUREAU OF INDIAN...

  8. PRODUCTION OF URANIUM METAL BY CARBON REDUCTION

    DOEpatents

    Holden, R.B.; Powers, R.M.; Blaber, O.J.

    1959-09-22

    The preparation of uranium metal by the carbon reduction of an oxide of uranium is described. In a preferred embodiment of the invention a charge composed of carbon and uranium oxide is heated to a solid mass after which it is further heated under vacuum to a temperature of about 2000 deg C to produce a fused uranium metal. Slowly ccoling the fused mass produces a dendritic structure of uranium carbide in uranium metal. Reacting the solidified charge with deionized water hydrolyzes the uranium carbide to finely divide uranium dioxide which can be separated from the coarser uranium metal by ordinary filtration methods.

  9. Occurrence of radium-224, radium-226, and radium-228 in water of the unconfined Kirkwood-Cohansey aquifer system, southern New Jersey

    USGS Publications Warehouse

    Szabo, Zoltan; dePaul, Vincent T.; Kraemer, Thomas F.; Parsa, Bahman

    2005-01-01

    Water in the unconfined Kirkwood-Cohansey aquifer system in the New Jersey Coastal Plain contains elevated concentrations (above 3 pCi/L (picocuries per liter)) of the alpha-particle-emitting radionuclide radium-224. Previously, water from the aquifer system had been found to contain radium-226 and radium-228. This observation is of concern because the previously undetected presence of radium-224 may pose an additional, quantifiable health risk that currently is not accounted for by the Maximum Contaminant Level (MCL) of 5 pCi/L for combined radium (the sum of radium-226 plus radium-228 is termed 'combined radium') in drinking water. Water samples were collected from a regional network of 88 wells for determination of concentrations of radium-224, radium-226, and radium-228; gross alpha-particle activity; and concentrations of major ions and selected trace elements. Both gamma and alpha spectroscopic techniques were used to determine concentrations of radium-224, which ranged from <0.5 to 16.8 pCi/L (median 2.1 pCi/L, interquartile range 1.2-3.7 pCi/L). Concentrations of radium-226 and radium-228 in the same samples ranged from <0.5 to 17.4 pCi/L (median 1.7 pCi/L, interquartile range 0.9-2.9 pCi/L) and <0.5 to 12.8 pCi/L (median 1.6 pCi/L, interquartile range, 0.9-2.6 pCi/L), respectively. Concentrations of radium-224 typically were greater than those of the other two radium radionuclides, as evidenced by the highest median, third quartile, and maximum concentrations, as well as the highest concentration among the three radium radioisotopes in 52 (59 percent) of the 88 samples. Concentrations of 5.0 to 5.5 pCi/L of radium-224 result in a gross alpha-particle activity of about 15 pCi/L (the MCL) 36 to 48 hours, respectively, after sample collection when ingrowth of radium-224 progeny radionuclides is considered, even with the unlikely assumption that no other alpha-particle-emitting radionuclide is present in the water. Concentrations of 3.4 to 3.7 pCi/L radium-224 result in a gross alpha-particle activity of 10 pCi/L 36 to 48 hours, respectively, after sample collection when ingrowth of Ra-224 progeny radionuclides is considered. In this latter case, it is possible that the summed alpha-particle activity from radium-226 present at a concentration less than or equal to 5 pCi/L (the MCL for combined radium) and from radium-224 present at a concentration about 3.4 pCi/L or greater may exceed the 15-pCi/L MCL for gross alpha-particle activity. In this study, gross alpha-particle activities were measured within 48 hours after sample collection and were found to exceed the MCL of 15 pCi/L in nearly half (43) of the 88 samples collected. The concentration of radium-224 exceeded that of radium-226 in 55 (62.5 percent) of the 88 samples. Concentrations of radium-224 correlate strongly with those of both radium-226 and radium-228 (Spearman correlation coefficients r=0.74 and 0.91, respectively). Concentrations of radium-224, radium-226, and radium-228 were greatest in the most acidic ground water. Concentrations of radium-224 and combined radium-226 and radium-228 in samples of ground water with pH less than 4.7 exceeded 5 pCi/L in 33 and 67 percent of the samples, respectively. Concentrations of radium-224, radium-226, and radium-228 (measured separately) were greatest in water from the southern part of the aquifer outcrop area. In water from the northern part of the aquifer system outcrop area, radium-224 concentrations were as high as 3.6 pCi/L, and concentrations of combined radium and gross alpha-particle activity in some samples exceeded their respective MCLs. The presence of gross alpha-particle activities greater than 15 pCi/L and combined radium-226 and radium-228 concentrations greater than 5 pCi/L in the southwestern part of the aquifer system outcrop area is common and had been documented before 1997. Results of this study confirm these earlier findings. In northeastern and southeastern parts of the aquifer

  10. STRIPPING OF URANIUM FROM ORGANIC EXTRACTANTS

    DOEpatents

    Crouse, D.J. Jr.

    1962-09-01

    A liquid-liquid extraction method is given for recovering uranium values from uranium-containing solutions. Uranium is removed from a uranium-containing organic solution by contacting said organic solution with an aqueous ammonium carbonate solution substantially saturated in uranium values. A uranium- containing precipitate is thereby formed which is separated from the organic and aqueous phases. Uranium values are recovered from this separated precipitate. (AE C)

  11. Process for electroslag refining of uranium and uranium alloys

    DOEpatents

    Lewis, P.S. Jr.; Agee, W.A.; Bullock, J.S. IV; Condon, J.B.

    1975-07-22

    A process is described for electroslag refining of uranium and uranium alloys wherein molten uranium and uranium alloys are melted in a molten layer of a fluoride slag containing up to about 8 weight percent calcium metal. The calcium metal reduces oxides in the uranium and uranium alloys to provide them with an oxygen content of less than 100 parts per million. (auth)

  12. Detection of depleted uranium in urine of veterans from the 1991 Gulf War.

    PubMed

    Gwiazda, R H; Squibb, K; McDiarmid, M; Smith, D

    2004-01-01

    American soldiers involved in "friendly fire" accidents during the 1991 Gulf War were injured with depleted-uranium-containing fragments or possibly exposed to depleted uranium via other routes such as inhalation, ingestion, and/or wound contamination. To evaluate the presence of depleted uranium in these soldiers eight years later, the uranium concentration and depleted uranium content of urine samples were determined by inductively coupled plasma mass spectrometry in (a) depleted uranium exposed soldiers with embedded shrapnel, (b) depleted uranium exposed soldiers with no shrapnel, and (c) a reference group of deployed soldiers not involved in the friendly fire incidents. Uranium isotopic ratios measured in many urine samples injected directly into the inductively coupled plasma mass spectrometer and analyzed at a mass resolution m/delta m of 300 appeared enriched in 235U with respect to natural abundance (0.72%) due to the presence of an interference of a polyatomic molecule of mass 234.81 amu that was resolved at a mass resolution m/delta m of 4,000. The 235U abundance measured on uranium separated from these urines by anion exchange chromatography was clearly natural or depleted. Urine uranium concentrations of soldiers with shrapnel were higher than those of the two other groups, and 16 out of 17 soldiers with shrapnel had detectable depleted uranium in their urine. In depleted uranium exposed soldiers with no shrapnel, depleted uranium was detected in urine samples of 10 out of 28 soldiers. The median uranium concentration of urines with depleted uranium from soldiers without shrapnel was significantly higher than in urines with no depleted uranium, though substantial overlap in urine uranium concentrations existed between the two groups. Accordingly, assessment of depleted uranium exposure using urine must rely on uranium isotopic analyses, since urine uranium concentration is not an unequivocal indicator of depleted uranium presence in soldiers with no embedded shrapnel.

  13. 31 CFR 540.317 - Uranium feed; natural uranium feed.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Uranium feed; natural uranium feed... (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.317 Uranium feed; natural uranium feed. The...

  14. 31 CFR 540.317 - Uranium feed; natural uranium feed.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Uranium feed; natural uranium feed... (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.317 Uranium feed; natural uranium feed. The...

  15. 31 CFR 540.317 - Uranium feed; natural uranium feed.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Uranium feed; natural uranium feed... (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.317 Uranium feed; natural uranium feed. The...

  16. Prognostic Value of microRNA-224 in Various Cancers: A Meta-analysis.

    PubMed

    Zhang, Yue; Guo, Cong-Cong; Guan, Dong-Hui; Yang, Chuan-Hua; Jiang, Yue-Hua

    2017-07-01

    During previous studies, microRNA-224 (miR-224) was frequently investigated and discovered to be of vital significance to prognosis of patients with various cancers. However, its accurate prognostic value has not been estimated worldwide. Herein, we performed meta-analysis to assess its potential predictive value in a variety of human tumors. Qualified researches were identified up to March 1, 2017 through performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews. Overall survival (OS), disease-free survival (DFS) or progression-free survival (PFS) as a prognosis for various cancers were extracted and calculated, if available. Pooled hazard ratios (HR) and 95% confidence intervals (CI) were calculated using Stata version 13.0 (StataCorp, College Station, Texas, USA). 22 eligible studies with 3000 patients were ultimately brought into the current meta-analysis. It suggested that high miR-224 expression was significantly associated with poor OS in tissue (HR = 1.43, 95% CI = 1.00-2.03). During multivariate analysis, high miR-224 expression was more significantly associated with OS in tissue (HR = 2.81, 95% CI = 1.91-4.13). Likewise, there were significant associations between tissue miR-224 expression and colorectal cancer (CRC), diffuse large B-cell lymphoma (DLBCL) and gastric cancer (GC) patients (p <0.05). Nevertheless, there were not significant associations between high tissue miR-224 expression and DFS (HR = 2.15, 95% CI = 0.97-4.79) or PFS (HR = 0.92, 95% CI = 0.53-1.59). As far as the present researches are concerned, tissue miR-224 has a significantly prognostic value in various cancers, especially in CRC, DLBCL and GC. Due to the complicated pathogenesis of cancers, more large-scale and standard researches are requisite. Copyright © 2017 IMSS. Published by Elsevier Inc. All rights reserved.

  17. The biological effects of radium-224 injected into dogs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Muggenburg, B.A.; Hahn, F.F.; Boecker, B.B.

    1996-08-01

    A life-span study was conducted in 128 beagle dogs to determine the biological effects of intravenously injected {sup 224}Ra chloride. The {sup 224}Ra chloride was prepared by the same method used for intravenous injections in humans who were treated for ankylosing spondylitis and tuberculosis. Thus the results obtained from dogs can be compared directly to the population of treated humans, both for the elucidation of the effect of exposure rate and for comparison with other radionuclides for which data for humans are unavailable. Using equal numbers of males and females, the dogs were injected with one of four levels ofmore » {sup 224}Ra resulting in initial body burdens of approximately 13, 40, 120 or 350 kBq of {sup 224}Ra kg{sup -1} body mass. A control group of dogs was injected with diluent only. All dogs were divided further into three groups for which the amount of injected {sup 224}Ra (half-life of 3.62 days) or diluent was given in a single injection or divided equally into 10 or 50 weekly injections. As a result of these three injection schedules, the accumulation of dose from the injected {sup 224}Ra was distributed over approximately 1, 3 or 12 months. Each injection schedule included four different injection levels resulting in average absorbed {alpha}-particle doses to bone of 0.1, 0.3, 1 and 3 Gy, respectively. The primary early effect observed was a hematological dyscrasia in the dogs receiving either of the two highest injection levels. The effect was most severe in the dogs receiving a single injection of {sup 224}Ra and resulted in the death of three dogs injected at the highest level. The late-occurring biological effects were tumors. Bone tumors were the most common followed by tumors in the nasal mucosa. 52 refs., 8 figs., 8 tabs.« less

  18. Process for electrolytically preparing uranium metal

    DOEpatents

    Haas, Paul A.

    1989-01-01

    A process for making uranium metal from uranium oxide by first fluorinating uranium oxide to form uranium tetrafluoride and next electrolytically reducing the uranium tetrafluoride with a carbon anode to form uranium metal and CF.sub.4. The CF.sub.4 is reused in the fluorination reaction rather than being disposed of as a hazardous waste.

  19. Process for electrolytically preparing uranium metal

    DOEpatents

    Haas, Paul A.

    1989-08-01

    A process for making uranium metal from uranium oxide by first fluorinating uranium oxide to form uranium tetrafluoride and next electrolytically reducing the uranium tetrafluoride with a carbon anode to form uranium metal and CF.sub.4. The CF.sub.4 is reused in the fluorination reaction rather than being disposed of as a hazardous waste.

  20. Decontamination of uranium-contaminated waste oil using supercritical fluid and nitric acid.

    PubMed

    Sung, Jinhyun; Kim, Jungsoo; Lee, Youngbae; Seol, Jeunggun; Ryu, Jaebong; Park, Kwangheon

    2011-07-01

    The waste oil used in nuclear fuel processing is contaminated with uranium because of its contact with materials or environments containing uranium. Under current law, waste oil that has been contaminated with uranium is very difficult to dispose of at a radioactive waste disposal site. To dispose of the uranium-contaminated waste oil, the uranium was separated from the contaminated waste oil. Supercritical R-22 is an excellent solvent for extracting clean oil from uranium-contaminated waste oil. The critical temperature of R-22 is 96.15 °C and the critical pressure is 49.9 bar. In this study, a process to remove uranium from the uranium-contaminated waste oil using supercritical R-22 was developed. The waste oil has a small amount of additives containing N, S or P, such as amines, dithiocarbamates and dialkyldithiophosphates. It seems that these organic additives form uranium-combined compounds. For this reason, dissolution of uranium from the uranium-combined compounds using nitric acid was needed. The efficiency of the removal of uranium from the uranium-contaminated waste oil using supercritical R-22 extraction and nitric acid treatment was determined.

  1. Diffusive gradient in thin FILMS (DGT) compared with soil solution and labile uranium fraction for predicting uranium bioavailability to ryegrass.

    PubMed

    Duquène, L; Vandenhove, H; Tack, F; Van Hees, M; Wannijn, J

    2010-02-01

    The usefulness of uranium concentration in soil solution or recovered by selective extraction as unequivocal bioavailability indices for uranium uptake by plants is still unclear. The aim of the present study was to test if the uranium concentration measured by the diffusive gradient in thin films (DGT) technique is a relevant substitute for plant uranium availability in comparison to uranium concentration in the soil solution or uranium recovered by ammonium acetate. Ryegrass (Lolium perenne L. var. Melvina) is grown in greenhouse on a range of uranium spiked soils. The DGT-recovered uranium concentration (C(DGT)) was correlated with uranium concentration in the soil solution or with uranium recovered by ammonium acetate extraction. Plant uptake was better predicted by the summed soil solution concentrations of UO(2)(2+), uranyl carbonate complexes and UO(2)PO(4)(-). The DGT technique did not provide significant advantages over conventional methods to predict uranium uptake by plants. Copyright 2009 Elsevier Ltd. All rights reserved.

  2. 7 CFR 1280.224 - Periodic evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE LAMB PROMOTION, RESEARCH, AND INFORMATION ORDER Lamb Promotion, Research, and Information Order Reports, Books, and Records § 1280.224...

  3. The use of γ-rays analysis by HPGe detector to assess the gross alpha and beta activities in waters.

    PubMed

    Casagrande, M F S; Bonotto, D M

    2018-07-01

    This paper describes an alternative method for evaluating gross alpha and beta radioactivity in waters by using γ-rays analysis performed with hyper-pure germanium detector (HPGe). Several gamma emissions related to α and β - decays were used to provide the activity concentration data due to natural radionuclides commonly present in waters like 40 K and those belonging to the 238 U and 232 Th decay series. The most suitable gamma emissions related to β - decays were 214 Bi (1120.29 keV, 238 U series) and 208 Tl (583.19 keV, 232 Th series) as the equation in activity concentration yielded values compatible to those generated by the formula taking into account the detection efficiency. The absence of isolated and intense γ-rays peaks associated to α decays limited the choice to 226 Ra (186.21 keV, 238 U series) and 224 Ra (240.99 keV, 232 Th series). In these cases, it was adopted appropriate correction factors involving the absolute intensities and specific activities for avoiding the interferences of other γ-rays energies. The critical level of detection across the 186-1461 keV energy region corresponded to 0.010, 0.023, 0.038, 0.086, and 0.042 Bq/L, respectively, for 226 Ra, 224 Ra, 208 Tl, 214 Bi and 40 K. It is much lower than the WHO guideline reference value for gross alpha (0.5 Bq/L) and beta (1.0 Bq/L) in waters. The method applicability was checked by the analysis of groundwater samples from different aquifer systems occurring in the Brazilian states of São Paulo, Minas Gerais and Mato Grosso do Sul. The waters exhibit very different chemical composition and the samples with the highest radioactivity levels were those associated with lithotypes possessing enhanced uranium and thorium levels. The technique allowed directly discard the 40 K contribution to the gross beta activity as potassium is an essential element for humans. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. URANIUM LEACHING AND RECOVERY PROCESS

    DOEpatents

    McClaine, L.A.

    1959-08-18

    A process is described for recovering uranium from carbonate leach solutions by precipitating uranium as a mixed oxidation state compound. Uranium is recovered by adding a quadrivalent uranium carbon;te solution to the carbonate solution, adjusting the pH to 13 or greater, and precipitating the uranium as a filterable mixed oxidation state compound. In the event vanadium occurs with the uranium, the vanadium is unaffected by the uranium precipitation step and remains in the carbonate solution. The uranium-free solution is electrolyzed in the cathode compartment of a mercury cathode diaphragm cell to reduce and precipitate the vanadium.

  5. Plutonium recovery from spent reactor fuel by uranium displacement

    DOEpatents

    Ackerman, John P.

    1992-01-01

    A process for separating uranium values and transuranic values from fission products containing rare earth values when the values are contained together in a molten chloride salt electrolyte. A molten chloride salt electrolyte with a first ratio of plutonium chloride to uranium chloride is contacted with both a solid cathode and an anode having values of uranium and fission products including plutonium. A voltage is applied across the anode and cathode electrolytically to transfer uranium and plutonium from the anode to the electrolyte while uranium values in the electrolyte electrolytically deposit as uranium metal on the solid cathode in an amount equal to the uranium and plutonium transferred from the anode causing the electrolyte to have a second ratio of plutonium chloride to uranium chloride. Then the solid cathode with the uranium metal deposited thereon is removed and molten cadmium having uranium dissolved therein is brought into contact with the electrolyte resulting in chemical transfer of plutonium values from the electrolyte to the molten cadmium and transfer of uranium values from the molten cadmium to the electrolyte until the first ratio of plutonium chloride to uranium chloride is reestablished.

  6. Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity.

    PubMed

    Homma-Takeda, Shino; Kitahara, Keisuke; Suzuki, Kyoko; Blyth, Benjamin J; Suya, Noriyoshi; Konishi, Teruaki; Terada, Yasuko; Shimada, Yoshiya

    2015-12-01

    Renal toxicity is a hallmark of uranium exposure, with uranium accumulating specifically in the S3 segment of the proximal tubules causing tubular damage. As the distribution, concentration and dynamics of accumulated uranium at the cellular level is not well understood, here, we report on high-resolution quantitative in situ measurements by high-energy synchrotron radiation X-ray fluorescence analysis in renal sections from a rat model of uranium-induced acute renal toxicity. One day after subcutaneous administration of uranium acetate to male Wistar rats at a dose of 0.5 mg uranium kg(-1) body weight, uranium concentration in the S3 segment of the proximal tubules was 64.9 ± 18.2 µg g(-1) , sevenfold higher than the mean renal uranium concentration (9.7 ± 2.4 µg g(-1) ). Uranium distributed into the epithelium of the S3 segment of the proximal tubules and highly concentrated uranium (50-fold above mean renal concentration) in micro-regions was found near the nuclei. These uranium levels were maintained up to 8 days post-administration, despite more rapid reductions in mean renal concentration. Two weeks after uranium administration, damaged areas were filled with regenerating tubules and morphological signs of tissue recovery, but areas of high uranium concentration (100-fold above mean renal concentration) were still found in the epithelium of regenerating tubules. These data indicate that site-specific accumulation of uranium in micro-regions of the S3 segment of the proximal tubules and retention of uranium in concentrated areas during recovery are characteristics of uranium behavior in the kidney. Copyright © 2015 John Wiley & Sons, Ltd.

  7. Method of preparation of uranium nitride

    DOEpatents

    Kiplinger, Jaqueline Loetsch; Thomson, Robert Kenneth James

    2013-07-09

    Method for producing terminal uranium nitride complexes comprising providing a suitable starting material comprising uranium; oxidizing the starting material with a suitable oxidant to produce one or more uranium(IV)-azide complexes; and, sufficiently irradiating the uranium(IV)-azide complexes to produce the terminal uranium nitride complexes.

  8. Measurement of 224Ra and 226Ra activities in natural waters using a radon-in-air monitor

    USGS Publications Warehouse

    Kim, G.; Burnett, W.C.; Dulaiova, H.; Swarzenski, P.W.; Moore, W.S.

    2001-01-01

    We report a simple new technique for measuring low-level radium isotopes (224Ra and 226Ra) in natural waters. The radium present in natural waters is first preconcentrated onto MnO2-coated acrylic fiber (Mn fiber) in a column mode. The radon produced from the adsorbed radium is then circulated through a closed air-loop connected to a commercial radon-in-air monitor. The monitor counts alpha decays of radon daughters (polonium isotopes) which are electrostatically collected onto a silicon semiconductor detector. Count data are collected in energy-specific windows, which eliminate interference and maintain very low backgrounds. Radium-224 is measured immediately after sampling via 220Rn (216Po), and 226Ra is measured via 222Rn (218Po) after a few days of ingrowth of 222Rn. This technique is rapid, simple, and accurate for measurements of low-level 224Ra and 226Ra activities without requiring any wet chemistry. Rapid measurements of short-lived 222Rn and 224Ra, along with long-lived 226Ra, may thus be made in natural waters using a single portable system for environmental monitoring of radioactivity as well as tracing of various geochemical and geophysical processes. The technique could be especially useful for the on-site rapid determination of 224Ra which has recently been found to occur at elevated activities in some groundwater wells.

  9. MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

    PubMed Central

    Amankwatia, E B; Chakravarty, P; Carey, F A; Weidlich, S; Steele, R J C; Munro, A J; Wolf, C R; Smith, G

    2015-01-01

    Background: Colorectal cancers arise from benign adenomas, although not all adenomas progress to cancer and there are marked interpatient differences in disease progression. We have previously associated KRAS mutations with disease progression and reduced survival in colorectal cancer patients. Methods: We used TaqMan low-density array (TLDA) qRT–PCR analysis to identify miRNAs differentially expressed in normal colorectal mucosa, adenomas and cancers and in isogeneic KRAS WT and mutant HCT116 cells, and used a variety of phenotypic assays to assess the influence of miRNA expression on KRAS activity, chemosensitivity, proliferation and invasion. Results: MicroRNA-224 was differentially expressed in dysplastic colorectal disease and in isogeneic KRAS WT and mutant HCT116 cells. Antagomir-mediated miR-224 silencing in HCT116 KRAS WT cells phenocopied KRAS mutation, increased KRAS activity and ERK and AKT phosphorylation. 5-FU chemosensitivity was significantly increased in miR-224 knockdown cells, and in NIH3T3 cells expressing KRAS and BRAF mutant proteins. Bioinformatics analysis of predicted miR-224 target genes predicted altered cell proliferation, invasion and epithelial–mesenchymal transition (EMT) phenotypes that were experimentally confirmed in miR-224 knockdown cells. Conclusions: We describe a novel mechanism of KRAS regulation, and highlight the clinical utility of colorectal cancer-specific miRNAs as disease progression or clinical response biomarkers. PMID:25919696

  10. 10 CFR 760.1 - Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly (AEC) Domestic Uranium Program Circular 8, 10 CFR 60.8). 760.1 Section 760.1 Energy DEPARTMENT OF ENERGY DOMESTIC URANIUM PROGRAM § 760.1 Uranium leases on lands...

  11. 10 CFR 760.1 - Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly (AEC) Domestic Uranium Program Circular 8, 10 CFR 60.8). 760.1 Section 760.1 Energy DEPARTMENT OF ENERGY DOMESTIC URANIUM PROGRAM § 760.1 Uranium leases on lands...

  12. 10 CFR 760.1 - Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly (AEC) Domestic Uranium Program Circular 8, 10 CFR 60.8). 760.1 Section 760.1 Energy DEPARTMENT OF ENERGY DOMESTIC URANIUM PROGRAM § 760.1 Uranium leases on lands...

  13. 10 CFR 760.1 - Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly (AEC) Domestic Uranium Program Circular 8, 10 CFR 60.8). 760.1 Section 760.1 Energy DEPARTMENT OF ENERGY DOMESTIC URANIUM PROGRAM § 760.1 Uranium leases on lands...

  14. 10 CFR 760.1 - Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Uranium leases on lands controlled by DOE. (Domestic Uranium Program Circular No. 760.1, formerly (AEC) Domestic Uranium Program Circular 8, 10 CFR 60.8). 760.1 Section 760.1 Energy DEPARTMENT OF ENERGY DOMESTIC URANIUM PROGRAM § 760.1 Uranium leases on lands...

  15. PROCESS OF PRODUCING REFRACTORY URANIUM OXIDE ARTICLES

    DOEpatents

    Hamilton, N.E.

    1957-12-01

    A method is presented for fabricating uranium oxide into a shaped refractory article by introducing a uranium halide fluxing reagent into the uranium oxide, and then mixing and compressing the materials into a shaped composite mass. The shaped mass of uranium oxide and uranium halide is then fired at an elevated temperature so as to form a refractory sintered article. It was found in the present invention that the introduction of a uraninm halide fluxing agent afforded a fluxing action with the uranium oxide particles and that excellent cohesion between these oxide particles was obtained. Approximately 90% of uranium dioxide and 10% of uranium tetrafluoride represent a preferred composition.

  16. 31 CFR 540.309 - Natural uranium.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Natural uranium. 540.309 Section 540... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.309 Natural uranium. The term natural uranium means uranium found in...

  17. 31 CFR 540.309 - Natural uranium.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Natural uranium. 540.309 Section 540... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.309 Natural uranium. The term natural uranium means uranium found in...

  18. 31 CFR 540.309 - Natural uranium.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Natural uranium. 540.309 Section 540... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.309 Natural uranium. The term natural uranium means uranium found in...

  19. Rapid Radiochemical Method for Isotopic Uranium in Building ...

    EPA Pesticide Factsheets

    Technical Fact Sheet Analysis Purpose: Qualitative analysis Technique: Alpha spectrometry Method Developed for: Uranium-234, uranium-235, and uranium-238 in concrete and brick samples Method Selected for: SAM lists this method for qualitative analysis of uranium-234, uranium-235, and uranium-238 in concrete or brick building materials. Summary of subject analytical method which will be posted to the SAM website to allow access to the method.

  20. Plutonium recovery from spent reactor fuel by uranium displacement

    DOEpatents

    Ackerman, J.P.

    1992-03-17

    A process is described for separating uranium values and transuranic values from fission products containing rare earth values when the values are contained together in a molten chloride salt electrolyte. A molten chloride salt electrolyte with a first ratio of plutonium chloride to uranium chloride is contacted with both a solid cathode and an anode having values of uranium and fission products including plutonium. A voltage is applied across the anode and cathode electrolytically to transfer uranium and plutonium from the anode to the electrolyte while uranium values in the electrolyte electrolytically deposit as uranium metal on the solid cathode in an amount equal to the uranium and plutonium transferred from the anode causing the electrolyte to have a second ratio of plutonium chloride to uranium chloride. Then the solid cathode with the uranium metal deposited thereon is removed and molten cadmium having uranium dissolved therein is brought into contact with the electrolyte resulting in chemical transfer of plutonium values from the electrolyte to the molten cadmium and transfer of uranium values from the molten cadmium to the electrolyte until the first ratio of plutonium chloride to uranium chloride is reestablished.

  1. Assessment of the Technical Training Received by Source Selection Participants in Air Force Systems Command.

    DTIC Science & Technology

    1986-09-01

    60 48.4 Systems 200/400 15 12.1 Contract Administration (PPM 152) 13 10.5 Logistics Management (Log 224) 2 1.6 Government Contract Law (PPM 302) 20...detail. 1. Systems 200/400 2. Contract Administration (PPM 152) 3. Logistics Management (LOG 224) 4. Government Contract Law (PPM 302) 5. Technical...152 Contract Administration o Log 224 Logistics Management o PPM 302 Government Contract Law o QMT 345 Quantitative Technical, Cost, and Price Analysis

  2. 16. VIEW OF THE ENRICHED URANIUM RECOVERY SYSTEM. ENRICHED URANIUM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. VIEW OF THE ENRICHED URANIUM RECOVERY SYSTEM. ENRICHED URANIUM RECOVERY PROCESSED RELATIVELY PURE MATERIALS AND SOLUTIONS AND SOLID RESIDUES WITH RELATIVELY LOW URANIUM CONTENT. URANIUM RECOVERY INVOLVED BOTH SLOW AND FAST PROCESSES. (4/4/66) - Rocky Flats Plant, General Manufacturing, Support, Records-Central Computing, Southern portion of Plant, Golden, Jefferson County, CO

  3. 77 FR 51579 - Application for a License To Export High-Enriched Uranium

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Complex, July 30, 2012, August Uranium (93.35%). uranium-235 high-enriched 1, 2012, XSNM3726, 11006037. contained in 7.5 uranium in the kilograms uranium. form of broken metal to the Atomic Energy of Canada...

  4. Deposit model for volcanogenic uranium deposits

    USGS Publications Warehouse

    Breit, George N.; Hall, Susan M.

    2011-01-01

    The International Atomic Energy Agency's tabulation of volcanogenic uranium deposits lists 100 deposits in 20 countries, with major deposits in Russia, Mongolia, and China. Collectively these deposits are estimated to contain uranium resources of approximately 500,000 tons of uranium, which amounts to 6 percent of the known global resources. Prior to the 1990s, these deposits were considered to be small (less than 10,000 tons of uranium) with relatively low to moderate grades (0.05 to 0.2 weight percent of uranium). Recent availability of information on volcanogenic uranium deposits in Asia highlighted the large resource potential of this deposit type. For example, the Streltsovskoye district in eastern Russia produced more than 100,000 tons of uranium as of 2005; with equivalent resources remaining. Known volcanogenic uranium deposits within the United States are located in Idaho, Nevada, Oregon, and Utah. These deposits produced an estimated total of 800 tons of uranium during mining from the 1950s through the 1970s and have known resources of 30,000 tons of uranium. The most recent estimate of speculative resources proposed an endowment of 200,000 tons of uranium.

  5. 30 CFR 22.4 - Application procedures and requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS PORTABLE METHANE DETECTORS § 22.4 Application procedures and requirements. (a) Before MSHA will undertake an active investigation leading to approval of any methane...

  6. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2... surety bond. (b) Process agent means a resident agent for service of process. (c) State means a State...

  7. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2... surety bond. (b) Process agent means a resident agent for service of process. (c) State means a State...

  8. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2... surety bond. (b) Process agent means a resident agent for service of process. (c) State means a State...

  9. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2 Definitions. For purposes of this regulation: (a) Principal means the person or entity required to provide a...

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Siekhaus, W. J.; Teslich, N. E.; Weber, P. K.

    Depleted uranium that included carbide inclusions was sputtered with 30-keV gallium ions or 16-kev cesium ions to depths much greater than the ions’ range, i.e. using steady-state sputtering. The recession of both the uranium’s and uranium carbide’s surfaces and the ion corresponding fluences were used to determine the steady-state target sputtering yields of both uranium and uranium carbide, i.e. 6.3 atoms of uranium and 2.4 units of uranium carbide eroded per gallium ion, and 9.9 uranium atoms and 3.65 units of uranium carbide eroded by cesium ions. The steady state surface composition resulting from the simultaneous gallium or cesium implantationmore » and sputter-erosion of uranium and uranium carbide were calculated to be U₈₆Ga₁₄, (UC)₇₀Ga₃₀ and U₈₁Cs₉, (UC)₇₉Cs₂₁, respectively.« less

  11. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.

    PubMed

    Miller, Clint L; Haas, Ulrike; Diaz, Roxanne; Leeper, Nicholas J; Kundu, Ramendra K; Patlolla, Bhagat; Assimes, Themistocles L; Kaiser, Frank J; Perisic, Ljubica; Hedin, Ulf; Maegdefessel, Lars; Schunkert, Heribert; Erdmann, Jeanette; Quertermous, Thomas; Sczakiel, Georg

    2014-03-01

    Genome-wide association studies (GWAS) have identified chromosomal loci that affect risk of coronary heart disease (CHD) independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asians. The lead CHD-associated polymorphism in this region, rs12190287, resides in the 3' untranslated region (3'-UTR) of TCF21, a basic-helix-loop-helix transcription factor, and is predicted to alter the seed binding sequence for miR-224. Allelic imbalance studies in circulating leukocytes and human coronary artery smooth muscle cells (HCASMC) showed significant imbalance of the TCF21 transcript that correlated with genotype at rs12190287, consistent with this variant contributing to allele-specific expression differences. 3' UTR reporter gene transfection studies in HCASMC showed that the disease-associated C allele has reduced expression compared to the protective G allele. Kinetic analyses in vitro revealed faster RNA-RNA complex formation and greater binding of miR-224 with the TCF21 C allelic transcript. In addition, in vitro probing with Pb2+ and RNase T1 revealed structural differences between the TCF21 variants in proximity of the rs12190287 variant, which are predicted to provide greater access to the C allele for miR-224 binding. miR-224 and TCF21 expression levels were anti-correlated in HCASMC, and miR-224 modulates the transcriptional response of TCF21 to transforming growth factor-β (TGF-β) and platelet derived growth factor (PDGF) signaling in an allele-specific manner. Lastly, miR-224 and TCF21 were localized in human coronary artery lesions and anti-correlated during atherosclerosis. Together, these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2. These studies implicating rs12190287 in the miRNA-dependent regulation of TCF21, in conjunction with previous studies showing that this variant modulates transcriptional regulation through activator protein 1 (AP-1), suggests a unique bimodal level of complexity previously unreported for disease-associated variants.

  12. Uranium hydrogeochemical and stream sediment reconnaissance of the Newcastle NTMS Quadrangle, Wyoming, including concentrations of forty-two additional elements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Goff, S.J.; Sandoval, W.F.; Gallimore, D.L.

    1980-06-01

    Water and sediment samples were collected and each water sample was analyzed for U, and each sediment sample was analyzed for 43 elements, including U and Th. Uranium concentrations in water samples range from below the detection limit of 0.02 ppB to 702.26 ppB and have a median of 1.73 ppB and a mean of 11.76 ppB. Water samples containing high uranium concentrations generally are associated with known uranium mining activity or units known to be uranium bearing. About one-third of the water samples containing high uranium concentrations were collected from locations within the Pumpkin Buttes and Turnercrest-Ross Districts. Nearlymore » half of the water samples containing high uranium concentrations were collected from locations just west of the Monument Hill and Highland Flats-Box Creek Districts. Similar anomalous uranium concentrations in this region have been reported updip from Exxon's Highland uranium deposits. High uranium concentrations were also found associated with the Lance Creek-Old Woman Anticline District. Uranium concentrations in sediment samples range from 1.14 to 220.70 ppM and have a median of 3.37 ppM and a mean of 4.03 ppM. Throughout the major uranium mining districts of the Powder River Basin, sediment samples with high uranium concentrations were collected from dry streams located near wells producing water samples with high uranium concentrations. High uranium concentrations were also found associated with the Lance Creek oil field where uranium mineralization is known in the White River formation. High uranium concentrations were also found in sediment samples in areas where uranium mineralization is not known. These samples are from dry streams in areas underlain by the White River formation, the Niobrara formation, and the Pierre, Carlisle, Belle Fourche, and Mowry shales.« less

  13. Influence of uranium hydride oxidation on uranium metal behaviour

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Patel, N.; Hambley, D.; Clarke, S.A.

    2013-07-01

    This work addresses concerns that the rapid, exothermic oxidation of active uranium hydride in air could stimulate an exothermic reaction (burning) involving any adjacent uranium metal, so as to increase the potential hazard arising from a hydride reaction. The effect of the thermal reaction of active uranium hydride, especially in contact with uranium metal, does not increase in proportion with hydride mass, particularly when considering large quantities of hydride. Whether uranium metal continues to burn in the long term is a function of the uranium metal and its surroundings. The source of the initial heat input to the uranium, ifmore » sufficient to cause ignition, is not important. Sustained burning of uranium requires the rate of heat generation to be sufficient to offset the total rate of heat loss so as to maintain an elevated temperature. For dense uranium, this is very difficult to achieve in naturally occurring circumstances. Areas of the uranium surface can lose heat but not generate heat. Heat can be lost by conduction, through contact with other materials, and by convection and radiation, e.g. from areas where the uranium surface is covered with a layer of oxidised material, such as burned-out hydride or from fuel cladding. These rates of heat loss are highly significant in relation to the rate of heat generation by sustained oxidation of uranium in air. Finite volume modelling has been used to examine the behaviour of a magnesium-clad uranium metal fuel element within a bottle surrounded by other un-bottled fuel elements. In the event that the bottle is breached, suddenly, in air, it can be concluded that the bulk uranium metal oxidation reaction will not reach a self-sustaining level and the mass of uranium oxidised will likely to be small in relation to mass of uranium hydride oxidised. (authors)« less

  14. Influence of acidic and alkaline waste solution properties on uranium migration in subsurface sediments.

    PubMed

    Szecsody, Jim E; Truex, Mike J; Qafoku, Nikolla P; Wellman, Dawn M; Resch, Tom; Zhong, Lirong

    2013-08-01

    This study shows that acidic and alkaline wastes co-disposed with uranium into subsurface sediments have significant impact on changes in uranium retardation, concentration, and mass during downward migration. For uranium co-disposal with acidic wastes, significant rapid (i.e., hours) carbonate and slow (i.e., 100 s of hours) clay dissolution resulted, releasing significant sediment-associated uranium, but the extent of uranium release and mobility change was controlled by the acid mass added relative to the sediment proton adsorption capacity. Mineral dissolution in acidic solutions (pH2) resulted in a rapid (<10 h) increase in aqueous carbonate (with Ca(2+), Mg(2+)) and phosphate and a slow (100 s of hours) increase in silica, Al(3+), and K(+), likely from 2:1 clay dissolution. Infiltration of uranium with a strong acid resulted in significant shallow uranium mineral dissolution and deeper uranium precipitation (likely as phosphates and carbonates) with downward uranium migration of three times greater mass at a faster velocity relative to uranium infiltration in pH neutral groundwater. In contrast, mineral dissolution in an alkaline environment (pH13) resulted in a rapid (<10h) increase in carbonate, followed by a slow (10 s to 100 s of hours) increase in silica concentration, likely from montmorillonite, muscovite, and kaolinite dissolution. Infiltration of uranium with a strong base resulted in not only uranium-silicate precipitation (presumed Na-boltwoodite) but also desorption of natural uranium on the sediment due to the high ionic strength solution, or 60% greater mass with greater retardation compared with groundwater. Overall, these results show that acidic or alkaline co-contaminant disposal with uranium can result in complex depth- and time-dependent changes in uranium dissolution/precipitation reactions and uranium sorption, which alter the uranium migration mass, concentration, and velocity. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Uranium induces oxidative stress in lung epithelial cells

    PubMed Central

    Periyakaruppan, Adaikkappan; Kumar, Felix; Sarkar, Shubhashish; Sharma, Chidananda S.

    2009-01-01

    Uranium compounds are widely used in the nuclear fuel cycle, antitank weapons, tank armor, and also as a pigment to color ceramics and glass. Effective management of waste uranium compounds is necessary to prevent exposure to avoid adverse health effects on the population. Health risks associated with uranium exposure includes kidney disease and respiratory disorders. In addition, several published results have shown uranium or depleted uranium causes DNA damage, mutagenicity, cancer and neurological defects. In the current study, uranium toxicity was evaluated in rat lung epithelial cells. The study shows uranium induces significant oxidative stress in rat lung epithelial cells followed by concomitant decrease in the antioxidant potential of the cells. Treatment with uranium to rat lung epithelial cells also decreased cell proliferation after 72 h in culture. The decrease in cell proliferation was attributed to loss of total glutathione and superoxide dismutase in the presence of uranium. Thus the results indicate the ineffectiveness of antioxidant system’s response to the oxidative stress induced by uranium in the cells. PMID:17124605

  16. Uranium ores and depleted uranium in the environment, with a reference to uranium in the biosphere from the Erzgebirge/Sachsen, Germany.

    PubMed

    Meinrath, A; Schneider, P; Meinrath, G

    2003-01-01

    The Erzgebirge ('Ore Mountains') area in the eastern part of Germany was a major source of uranium for Soviet nuclear programs between 1945 and 1989. During this time, the former German Democratic Republic became the third largest uranium producer in the world. The high abundance of uranium in the geological formations of the Erzgebirge are mirrored in the discovery of uranium by M. Klaproth close to Freiberg City in 1789 and the description of the so-called 'Schneeberg' disease, lung cancer caused in miners by the accumulation of the uranium decay product, radon, in the subsurfaces of shafts. Since 1991, remediation and mitigation of uranium at production facilities, rock piles and mill tailings has taken place. In parallel, efforts were initiated to assess the likely adverse effects of uranium mining to humans. The costs of these activities amount to about 6.5 10(9) Euro. A comparison with concentrations of depleted uranium at certain sites is given.

  17. METHOD FOR RECOVERING URANIUM FROM OILS

    DOEpatents

    Gooch, L.H.

    1959-07-14

    A method is presented for recovering uranium from hydrocarbon oils, wherein the uranium is principally present as UF/sub 4/. According to the invention, substantially complete removal of the uranium from the hydrocarbon oil may be effected by intimately mixing one part of acetone to about 2 to 12 parts of the hydrocarbon oil containing uranium and separating the resulting cake of uranium from the resulting mixture. The uranium in the cake may be readily recovered by burning to the oxide.

  18. High strength and density tungsten-uranium alloys

    DOEpatents

    Sheinberg, Haskell

    1993-01-01

    Alloys of tungsten and uranium and a method for making the alloys. The amount of tungsten present in the alloys is from about 55 vol % to about 85 vol %. A porous preform is made by sintering consolidated tungsten powder. The preform is impregnated with molten uranium such that (1) uranium fills the pores of the preform to form uranium in a tungsten matrix or (2) uranium dissolves portions of the preform to form a continuous uranium phase containing tungsten particles.

  19. Influence of uncertainties of isotopic composition of the reprocessed uranium on effectiveness of its enrichment in gas centrifuge cascades

    NASA Astrophysics Data System (ADS)

    Smirnov, A. Yu; Mustafin, A. R.; Nevinitsa, V. A.; Sulaberidze, G. A.; Dudnikov, A. A.; Gusev, V. E.

    2017-01-01

    The effect of the uncertainties of the isotopic composition of the reprocessed uranium on its enrichment process in gas centrifuge cascades while diluting it by adding low-enriched uranium (LEU) and waste uranium. It is shown that changing the content of 232U and 236U isotopes in the initial reprocessed uranium within 15% (rel.) can significantly change natural uranium consumption and separative work (up to 2-3%). However, even in case of increase of these parameters is possible to find the ratio of diluents, where the cascade with three feed flows (depleted uranium, LEU and reprocessed uranium) will be more effective than ordinary separation cascade with one feed point for producing LEU from natural uranium.

  20. METHOD OF RECOVERING URANIUM COMPOUNDS

    DOEpatents

    Poirier, R.H.

    1957-10-29

    S>The recovery of uranium compounds which have been adsorbed on anion exchange resins is discussed. The uranium and thorium-containing residues from monazite processed by alkali hydroxide are separated from solution, and leached with an alkali metal carbonate solution, whereby the uranium and thorium hydrorides are dissolved. The carbonate solution is then passed over an anion exchange resin causing the uranium to be adsorbed while the thorium remains in solution. The uranium may be recovered by contacting the uranium-holding resin with an aqueous ammonium carbonate solution whereby the uranium values are eluted from the resin and then heating the eluate whereby carbon dioxide and ammonia are given off, the pH value of the solution is lowered, and the uranium is precipitated.

  1. Controlling intake of uranium in the workplace: Applications of biokinetic modeling and occupational monitoring data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leggett, Richard Wayne; Eckerman, Keith F; McGinn, Wilson

    2012-01-01

    This report provides methods for interpreting and applying occupational uranium monitoring data. The methods are based on current international radiation protection guidance, current information on the chemical toxicity of uranium, and best available biokinetic models for uranium. Emphasis is on air monitoring data and three types of bioassay data: the concentration of uranium in urine; the concentration of uranium in feces; and the externally measured content of uranium in the chest. Primary Reference guidance levels for prevention of chemical effects and limitation of radiation effects are selected based on a review of current scientific data and regulatory principles for settingmore » standards. Generic investigation levels and immediate action levels are then defined in terms of these primary guidance levels. The generic investigation and immediate actions levels are stated in terms of radiation dose and concentration of uranium in the kidneys. These are not directly measurable quantities, but models can be used to relate the generic levels to the concentration of uranium in air, urine, or feces, or the total uranium activity in the chest. Default investigation and immediate action levels for uranium in air, urine, feces, and chest are recommended for situations in which there is little information on the form of uranium taken into the body. Methods are prescribed also for deriving case-specific investigation and immediate action levels for uranium in air, urine, feces, and chest when there is sufficient information on the form of uranium to narrow the range of predictions of accumulation of uranium in the main target organs for uranium: kidneys for chemical effects and lungs for radiological effects. In addition, methods for using the information herein for alternative guidance levels, different from the ones selected for this report, are described.« less

  2. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gregoire, D.C.; Goltz, D.M.; Chakrabarti, C.L.

    Graphite furnace atomic absorption spectrometry (GFAAS) is an insensitive technique for determination of uranium. Experiments were conducted using electrothermal vaporization inductively coupled plasma mass spectrometry to investigate the atomization and vaporization of atomic and molecular uranium species in the graphite furnace. ETV-ICP-MS signals for uranium were observed at temperatures well below the appearance temperature of uranium atoms suggesting the vaporization of molecular uranium oxide at temperatures below 2000{degrees}C. Examination of individual uranium ETV-ICP-MS signals reveals the vaporization of uranium carbide at temperatures above 2600{degrees}C. Chemical modifiers such as 0.2% HF and 0.1% CHF{sub 3} in the argon carrier gas, weremore » ineffective in preventing the formation of uranium carbide at 2700{degrees}C. Vaporization of uranium from a tungsten surface using tungsten foil inserted into the graphite tube prevented the formation of uranium carbide and eliminated the ETV-ICP-MS signal suppression caused by a sodium chloride matrix.« less

  3. 25 CFR 224.10 - What is the purpose of this part?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AGREEMENTS UNDER THE INDIAN TRIBAL ENERGY DEVELOPMENT AND SELF DETERMINATION ACT General Provisions § 224.10... resource development on tribal land; and (b) Describes the process for obtaining, implementing, and...

  4. PRODUCTION OF PURIFIED URANIUM

    DOEpatents

    Burris, L. Jr.; Knighton, J.B.; Feder, H.M.

    1960-01-26

    A pyrometallurgical method for processing nuclear reactor fuel elements containing uranium and fission products and for reducing uranium compound; to metallic uranium is reported. If the material proccssed is essentially metallic uranium, it is dissolved in zinc, the sulution is cooled to crystallize UZn/sub 9/ , and the UZn/sub 9/ is distilled to obtain uranium free of fission products. If the material processed is a uranium compound, the sollvent is an alloy of zinc and magnesium and the remaining steps are the same.

  5. METHOD OF SEPARATING URANIUM VALUES, PLUTONIUM VALUES AND FISSION PRODUCTS BY CHLORINATION

    DOEpatents

    Brown, H.S.; Seaborg, G.T.

    1959-02-24

    The separation of plutonium and uranium from each other and from other substances is described. In general, the method comprises the steps of contacting the uranium with chlorine in the presence of a holdback material selected from the group consisting of lanthanum oxide and thorium oxide to form a uranium chloride higher than uranium tetrachloride, and thereafter heating the uranium chloride thus formed to a temperature at which the uranium chloride is volatilized off but below the volatilizalion temperature of plutonium chloride.

  6. SOLVENT EXTRACTION PROCESS FOR URANIUM RECOVERY

    DOEpatents

    Clark, H.M.; Duffey, D.

    1958-06-17

    A process is described for extracting uranium from uranium ore, wherein the uranium is substantially free from molybdenum contamination. In a solvent extraction process for recovering uranium, uranium and molybdenum ions are extracted from the ore with ether under high acidity conditions. The ether phase is then stripped with water at a lower controiled acidity, resaturated with salting materials such as sodium nitrate, and reextracted with the separation of the molybdenum from the uranium without interference from other metals that have been previously extracted.

  7. 78 FR 17450 - Notice of Issuance of Materials License Renewal, Operating License SUA-1341, Uranium One USA, Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-21

    ... License Renewal, Operating License SUA-1341, Uranium One USA, Inc., Willow Creek Uranium In Situ Recovery.... SUA- 1341 to Uranium One USA, Inc. (Uranium One) for its Willow Creek Uranium In Situ Recovery (ISR) Project in Johnson and Campbell Counties, Wyoming. ADDRESSES: Please refer to Docket ID NRC-2009-0036 when...

  8. Reactive transport modeling at uranium in situ recovery sites: uncertainties in uranium sorption on iron hydroxides

    USGS Publications Warehouse

    Johnson, Raymond H.; Tutu, Hlanganani; Brown, Adrian; Figueroa, Linda; Wolkersdorfer, Christian

    2013-01-01

    Geochemical changes that can occur down gradient from uranium in situ recovery (ISR) sites are important for various stakeholders to understand when evaluating potential effects on surrounding groundwater quality. If down gradient solid-phase material consists of sandstone with iron hydroxide coatings (no pyrite or organic carbon), sorption of uranium on iron hydroxides can control uranium mobility. Using one-dimensional reactive transport models with PHREEQC, two different geochemical databases, and various geochemical parameters, the uncertainties in uranium sorption on iron hydroxides are evaluated, because these oxidized zones create a greater risk for future uranium transport than fully reduced zones where uranium generally precipitates.

  9. Method for the recovery of uranium values from uranium tetrafluoride

    DOEpatents

    Kreuzmann, Alvin B.

    1983-01-01

    The invention is a novel method for the recovery of uranium from dry, particulate uranium tetrafluoride. In one aspect, the invention comprises reacting particulate uranium tetrafluoride and calcium oxide in the presence of gaseous oxygen to effect formation of the corresponding alkaline earth metal uranate and alkaline earth metal fluoride. The product uranate is highly soluble in various acidic solutions wherein the product fluoride is virtually insoluble therein. The product mixture of uranate and alkaline earth metal fluoride is contacted with a suitable acid to provide a uranium-containing solution, from which the uranium is recovered. The invention can achieve quantitative recovery of uranium in highly pure form.

  10. Method for the recovery of uranium values from uranium tetrafluoride

    DOEpatents

    Kreuzmann, A.B.

    1982-10-27

    The invention is a novel method for the recovery of uranium from dry, particulate uranium tetrafluoride. In one aspect, the invention comprises reacting particulate uranium tetrafluoride and calcium oxide in the presence of gaseous oxygen to effect formation of the corresponding alkaline earth metal uranate and alkaline earth metal fluoride. The product uranate is highly soluble in various acidic solutions whereas the product fluoride is virtually insoluble therein. The product mixture of uranate and alkaline earth metal fluoride is contacted with a suitable acid to provide a uranium-containing solution, from which the uranium is recovered. The invention can achieve quantitative recovery of uranium in highly pure form.

  11. Fate of Uranium in Wetlands: Impact of Drought Followed by Re-flooding

    NASA Astrophysics Data System (ADS)

    Gilson, E.; Huang, S.; Koster van Groos, P. G.; Scheckel, K.; Peacock, A. D.; Kaplan, D. I.; Jaffe, P. R.

    2014-12-01

    Uranium contamination in groundwater can be mitigated in anoxic zones by iron-reducing bacteria that reduce soluble U(VI) to insoluble U(IV) and by uranium immobilization through complexation and sorption. Wetlands often link ground and surface-waters, making them strategic systems for potentially limiting migration of uranium contamination. Little is known about how drought periods that result in the drying of wetland soils, and consequent redox changes, affect uranium fate and transport in wetlands. In order to better understand the fate and stability of immobilized uranium in wetland soils, and how dry periods affect the uranium stability, we dosed saturated wetland mesocosms planted with Scirpus acutus with low levels of uranyl-acetate for 5 months before imposing a 9-day drying period followed by a 13-day rewetting period. Concentrations of uranium in mesocosm effluent increased after rewetting, but the cumulative amount of uranium released in the 13 days following the drying constituted less than 1% of the uranium immobilized in the soil during the 5 months prior to the drought. This low level of remobilization suggests that the uranium immobilized in these soils was not primarily bioreduced U(IV), which could have been oxidized to soluble U(VI) during the drought and released in the effluent during the subsequent flood. XANES analyses confirm that most of the uranium immobilized in the mesocosms was U(VI) sorbed to iron oxides. Compared to mesocosms that did not experience drying or rewetting, mesocosms that were sacrificed immediately after drying and after 13 days of rewetting had less uranium in soil near roots and more uranium on root surfaces. Metal-reducing bacteria only dominated the bacterial community after 13 days of rewetting and not immediately after drying, indicating that these bacteria are not responsible for this redistribution of uranium after the drying and rewetting. Results show that short periods of drought conditions in a wetland may impact uranium distribution, but these conditions may not cause large losses of immobilized uranium from the wetland.

  12. The distribution of uranium and thorium in granitic rocks of the basin and range province, Western United States

    USGS Publications Warehouse

    McNeal, J.M.; Lee, D.E.; Millard, H.T.

    1981-01-01

    Some secondary uranium deposits are thought to have formed from uranium derived by the weathering of silicic igneous rocks such as granites, rhyolites, and tuffs. A regional geochemical survey was made to determine the distribution of uranium and thorium in granitic rocks of the Basin and Range province in order to evaluate the potential for secondary uranium occurrences in the area. The resulting geochemical maps of uranium, thorium, and the Th:U ratio may be useful in locating target areas for uranium exploration. The granites were sampled according to a five-level, nested, analysis-of-variance design, permitting estimates to be made of the variance due to differences between:(1) two-degree cells; (2) one-degree cells; (3) plutons; (4) samples; and (5) analyses. The cells are areas described in units of degrees of latitude and longitude. The results show that individual plutons tend to differ in uranium and thorium concentrations, but that each pluton tends to be relatively homogeneous. Only small amounts of variance occur at the two degree and the between-analyses levels. The three geochemical maps that were prepared are based on one-degree cell means. The reproducibility of the maps is U > Th ??? Th:U. These geochemical maps may be used in three methods of locating target areas for uranium exploration. The first method uses the concept that plutons containing the greatest amounts of uranium may supply the greatest amounts of uranium for the formation of secondary uranium occurrences. The second method is to examine areas with high thorium contents, because thorium and uranium are initially highly correlated but much uranium could be lost by weathering. The third method is to locate areas in which the plutons have particularly high Th:U ratios. Because uranium, but not thorium, is leached by chemical weathering, high Th:U ratios suggest a possible loss of uranium and possibly a greater potential for secondary uranium occurrences to be found in the area. ?? 1981.

  13. Hydrologic and Temporal Influences of Evaporite Minerals on the Vertical Distribution, Storage, and Mobility of Uranium

    NASA Astrophysics Data System (ADS)

    Roycroft, S. J.; Noel, V.; Boye, K.; Besancon, C.; Weaver, K. L.; Johnson, R. H.; Dam, W. L.; Fendorf, S. E.; Bargar, J.

    2016-12-01

    Uranium contaminated groundwater in Riverton, Wyoming persists despite anticipated natural attenuation outside of a former uranium ore processing facility. The inability of natural flushing to dilute the uranium below the regulatory threshold indicates that sediments act as secondary sources likely (re)supplying uranium to groundwater. Throughout the contaminated floodplain, uranium rich-evaporites are readily abundant in the upper 2 m of sediments and are spatially coincident with the location of the plume, which suggests a likely link between evaporites and increased uranium levels. Knowledge of where and how uranium is stored within evaporite-associated sediments is required to understand processes controlling the mobility of uranium. We expect that flooding and seasonal changes in hydrologic conditions will affect U phase partitioning, and thus largely control U mobility. The primary questions we are addressing in this project are: What is the relative abundance of uranium incorporated in various mineral complexes throughout the evaporite sediments? How do the factors of depth, location, and seasonality influence the relative incorporation, mobility and speciation of uranium?We have systematically sampled from two soil columns over three dates in Riverton. The sampling dates span before and after a significant flooding event, providing insight into the flood's impact on local uranium mobility. Sequential chemical extractions are used to decipher the reactivity of uranium and approximate U operationally defined within reactants targeting carbonate, silicate, organic, and metal oxide bound or water and exchangeable phases. Extractions throughout the entirety of the sediment cores provide a high-resolution vertical profile of the distribution of uranium in various extracted phases. Throughout the profile, the majority (50-60%) of uranium is bound within carbonate-targeted extracts, a direct effect of the carbonate-rich evaporite sediments. The sum of our analyses provide a dynamic model of uranium incorporation within evaporite sediments holding implications for the fate of uranium throughout contaminated sites across the Colorado River Basin.

  14. Inherently safe in situ uranium recovery

    DOEpatents

    Krumhansl, James L; Brady, Patrick V

    2014-04-29

    An in situ recovery of uranium operation involves circulating reactive fluids through an underground uranium deposit. These fluids contain chemicals that dissolve the uranium ore. Uranium is recovered from the fluids after they are pumped back to the surface. Chemicals used to accomplish this include complexing agents that are organic, readily degradable, and/or have a predictable lifetime in an aquifer. Efficiency is increased through development of organic agents targeted to complexing tetravalent uranium rather than hexavalent uranium. The operation provides for in situ immobilization of some oxy-anion pollutants under oxidizing conditions as well as reducing conditions. The operation also artificially reestablishes reducing conditions on the aquifer after uranium recovery is completed. With the ability to have the impacted aquifer reliably remediated, the uranium recovery operation can be considered inherently safe.

  15. Uranium concentrations in groundwater, northeastern Washington

    USGS Publications Warehouse

    Kahle, Sue C.; Welch, Wendy B.; Tecca, Alison E.; Eliason, Devin M.

    2018-04-18

    A study of uranium in groundwater in northeastern Washington was conducted to make a preliminary assessment of naturally occurring uranium in groundwater relying on existing information and limited reconnaissance sampling. Naturally occurring uranium is associated with granitic and metasedimentary rocks, as well as younger sedimentary deposits, that occur in this region. The occurrence and distribution of uranium in groundwater is poorly understood. U.S. Environmental Protection Agency (EPA) regulates uranium in Group A community water systems at a maximum contaminant level (MCL) of 30 μg/L in order to reduce uranium exposure, protect from toxic kidney effects of uranium, and reduce the risk of cancer. However, most existing private wells in the study area, generally for single family use, have not been sampled for uranium. This document presents available uranium concentration data from throughout a multi-county region, identifies data gaps, and suggests further study aimed at understanding the occurrence of uranium in groundwater.The study encompasses about 13,000 square miles (mi2) in the northeastern part of Washington with a 2010 population of about 563,000. Other than the City of Spokane, most of the study area is rural with small towns interspersed throughout the region. The study area also includes three Indian Reservations with small towns and scattered population. The area has a history of uranium exploration and mining, with two inactive uranium mines on the Spokane Indian Reservation and one smaller inactive mine on the outskirts of Spokane. Historical (1977–2016) uranium in groundwater concentration data were used to describe and illustrate the general occurrence and distribution of uranium in groundwater, as well as to identify data deficiencies. Uranium concentrations were detected at greater than 1 microgram per liter (μg/L) in 60 percent of the 2,382 historical samples (from wells and springs). Uranium concentrations ranged from less than 1 to 88,600 μg/L, and the median concentration of uranium in groundwater for all sites was 1.4 μg/L.New (2017) uranium in groundwater concentration data were obtained by sampling 13 private domestic wells for uranium in areas without recent (2000s) water-quality data. Uranium was detected in all 13 wells sampled for this study; concentrations ranged from 1.03 to 1,180 μg/L with a median of 22 μg/L. Uranium concentrations of groundwater samples from 6 of the 13 wells exceeded the MCL for uranium. Uranium concentrations in water samples from two wells were 1,130 and 1,180 μg/L, respectively; nearly 40 times the MCL.Additional data collection and analysis are needed in rural areas where self-supplied groundwater withdrawals are the primary source of water for human consumption. Of the roughly 43,000 existing water wells in the study area, only 1,755 wells, as summarized in this document, have available uranium concentration data, and some of those data are decades old. Furthermore, analysis of area groundwater quality would benefit from a more extensive chemical-analysis suite including general chemistry in order to better understand local geochemical conditions that largely govern the mobility of uranium. Although the focus of the present study is uranium, it also is important to recognize that there are other radionuclides of concern that may be present in area groundwater.

  16. Corrective Action Decision Document for Corrective Action Unit 224: Decon Pad and Septic Systems Nevada Test Site, Nevada, Rev. No.: 0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    David A. Strand

    2005-05-01

    This Corrective Action Decision Document has been prepared for Corrective Action Unit (CAU) 224, Decon Pad and Septic Systems, in Areas 2, 3, 5, 6, 11, and 23 of the Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 224 is comprised of the following corrective action sites (CASs): (1) 02-04-01, Septic Tank (Buried); (2) 03-05-01, Leachfield; (3) 05-04-01, Septic Tanks (4)/Discharge Area; (4) 06-03-01, Sewage Lagoons (3); (5) 06-05-01, Leachfield; (6) 06-17-04, Decon Pad and Wastewater Catch; (7) 06-23-01, Decon Pad Discharge Piping; (8) 11-04-01, Sewage Lagoon; and (9) 23-05-02,more » Leachfield. The purpose of this Corrective Action Decision Document is to identify and provide the rationale for the recommendation of a corrective action alternative for the nine CASs within CAU 224. Corrective action investigation activities were performed from August 10, 2004, through January 18, 2005, as set forth in the CAU 224 Corrective Action Investigation Plan.« less

  17. DYNAMIC PROPERTIES OF SHOCK LOADED THIN URANIUM FOILS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robbins, D. L.; Kelly, A. M.; Alexander, D. J.

    A series of spall experiments has been completed with thin depleted uranium targets, nominally 0.1 mm thick. The first set of uranium spall targets was cut and ground to final thickness from electro-refined, high-purity, cast uranium. The second set was rolled to final thickness from low purity uranium. The impactors for these experiments were laser-launched 0.05-mm thick copper flyers, 3 mm in diameter. Laser energies were varied to yield a range of flyer impact velocities. This resulted in varying degrees of damage to the uranium spall targets, from deformation to complete spall or separation at the higher velocities. Dynamic measurementsmore » of the uranium target free surface velocities were obtained with dual velocity interferometers. Uranium targets were recovered and sectioned after testing. Free surface velocity profiles were similar for the two types of uranium, but spall strengths (estimated from the magnitude of the pull-back signal) are higher for the high-purity cast uranium. Velocity profiles and microstructural evidence of spall from the sectioned uranium targets are presented.« less

  18. Aftermath of Uranium Ore Processing on Floodplains: Lasting Effects of Uranium on Soil and Microbes

    NASA Astrophysics Data System (ADS)

    Tang, H.; Boye, K.; Bargar, J.; Fendorf, S. E.

    2016-12-01

    A former uranium ore processing site located between the Wind River and the Little Wind River near the city of Riverton, Wyoming, has generated a uranium plume in the groundwater within the floodplain. Uranium is toxic and poses a threat to human health. Thus, controlling and containing the spread of uranium will benefit the human population. The primary source of uranium was removed from the processing site, but a uranium plume still exists in the groundwater. Uranium in its reduced form is relatively insoluble in water and therefore is retained in organic rich, anoxic layers in the subsurface. However, with the aid of microbes uranium becomes soluble in water which could expose people and the environment to this toxin, if it enters the groundwater and ultimately the river. In order to better understand the mechanisms controlling uranium behavior in the floodplains, we examined sediments from three sediment cores (soil surface to aquifer). We determined the soil elemental concentrations and measured microbial activity through the use of several instruments (e.g. Elemental Analyzer, X-ray Fluorescence, MicroResp System). Through the data collected, we aim to obtain a better understanding of how the interaction of geochemical factors and microbial metabolism affect uranium mobility. This knowledge will inform models used to predict uranium behavior in response to land use or climate change in floodplain environments.

  19. New Technique for Speciation of Uranium in Sediments Following Acetate-Stimulated Bioremediation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2011-06-22

    Acetate-stimulated bioremediation is a promising new technique for sequestering toxic uranium contamination from groundwater. The speciation of uranium in sediments after such bioremediation attempts remains unknown as a result of low uranium concentration, and is important to analyzing the stability of sequestered uranium. A new technique was developed for investigating the oxidation state and local molecular structure of uranium from field site sediments using X-Ray Absorption Spectroscopy (XAS), and was implemented at the site of a former uranium mill in Rifle, CO. Glass columns filled with bioactive Rifle sediments were deployed in wells in the contaminated Rifle aquifer and amendedmore » with a hexavalent uranium (U(VI)) stock solution to increase uranium concentration while maintaining field conditions. This sediment was harvested and XAS was utilized to analyze the oxidation state and local molecular structure of the uranium in sediment samples. Extended X-Ray Absorption Fine Structure (EXAFS) data was collected and compared to known uranium spectra to determine the local molecular structure of the uranium in the sediment. Fitting was used to determine that the field site sediments did not contain uraninite (UO{sub 2}), indicating that models based on bioreduction using pure bacterial cultures are not accurate for bioremediation in the field. Stability tests on the monomeric tetravalent uranium (U(IV)) produced by bioremediation are needed in order to assess the efficacy of acetate-stimulation bioremediation.« less

  20. Health effects of uranium: new research findings.

    PubMed

    Brugge, Doug; Buchner, Virginia

    2011-01-01

    Recent plans for a nuclear renaissance in both established and emerging economies have prompted increased interest in uranium mining. With the potential for more uranium mining worldwide and a growth in the literature on the toxicology and epidemiology of uranium and uranium mining, we found it timely to review the current state of knowledge. Here, we present a review of the health effects of uranium mining, with an emphasis on newer findings (2005-2011). Uranium mining can contaminate air, water, and soil. The chemical toxicity of the metal constitutes the primary environmental health hazard, with the radioactivity of uranium a secondary concern. The update of the toxicologic evidence on uranium adds to the established findings regarding nephrotoxicity, genotoxicity, and developmental defects. Additional novel toxicologic findings, including some at the molecular level, are now emerging that raise the biological plausibility of adverse effects on the brain, on reproduction, including estrogenic effects, on gene expression, and on uranium metabolism. Historically, most epidemiology on uranium mining has focused on mine workers and radon exposure. Although that situation is still overwhelmingly true, a smaller emerging literature has begun to form around environmental exposure in residential areas near uranium mining and processing facilities. We present and critique such studies. Clearly, more epidemiologic research is needed to contribute to causal inference. As much damage is irreversible, and possibly cumulative, present efforts must be vigorous to limit environmental uranium contamination and exposure.

  1. METHOD OF APPLYING NICKEL COATINGS ON URANIUM

    DOEpatents

    Gray, A.G.

    1959-07-14

    A method is presented for protectively coating uranium which comprises etching the uranium in an aqueous etching solution containing chloride ions, electroplating a coating of nickel on the etched uranium and heating the nickel plated uranium by immersion thereof in a molten bath composed of a material selected from the group consisting of sodium chloride, potassium chloride, lithium chloride, and mixtures thereof, maintained at a temperature of between 700 and 800 deg C, for a time sufficient to alloy the nickel and uranium and form an integral protective coating of corrosion-resistant uranium-nickel alloy.

  2. A scanning electron microscopy study of the macro-crystalline structure of 2-(2,4-dinitrobenzyl) pyridine

    NASA Technical Reports Server (NTRS)

    Ware, Jacqueline; Hammond, Ernest C., Jr.

    1989-01-01

    The compound, 2-(2,4-dinitrobenzyl) pyridine, was synthesized in the laboratory; an introductory level electron microscopy study of the macro-crystalline structure was conducted using the scanning electron microscope (SEM). The structure of these crystals was compared with the macrostructure of the crystal of 2-(2,4-dinitrobenzyl) pyridinium bromide, the hydrobromic salt of the compound which was also synthesized in the laboratory. A scanning electron microscopy crystal study was combined with a study of the principle of the electron microscope.

  3. Uranium-bearing lignite in southwestern North Dakota

    USGS Publications Warehouse

    Moore, George W.; Melin, Robert E.; Kepferle, Roy C.

    1954-01-01

    Uranium-bearing lignite was mapped and sampled in the Bullion Butte, Sentinel Butte, HT Butte, and Chalky Buttes areas in southwestern North Dakota. The uraniferous lignite occurs at several stratigraphic positions in the Sentinel Butte member of the Fort Union formation of Paleocene age. A total of 261 samples were collected for uranium analysis from 85 localities, Lignite contained as much as 0.045 percent uranium, 10.0 percent ash, and 0.45 percent uranium in the ash was found although the average is lower. Inferred reserves for the four areas examined are estimated to be about 27 million tons of lignite in beds about 2 feet thick and containing more than 3000 tons of uranium. The lignite in beds about 2 feet thick and containing more than 3000 tons of uranium. The lignite averages more than 30 percent ash in the surface samples. The principal factor that seems to influence the uranium content of lignite beds is their stratigraphic position below the overlying rocks of the White River group of Oligocene age. All of the uranium-bearing beds closely underlie the base of the White River group. Although this relationship seems to be the controlling factor, the relative concentration of uranium may be modified by other conditions. Beds enclosed in permeable rocks are more uraniferous than beds in impermeable rocks, and thin beds have higher content of uranium than thick beds. In addition, thick lignite beds commonly have a top=preferential distribution of uranium. These and other factors suggest that the uranium is secondary and this it was introduced by ground water which had leached uranium from volcanic ash in the overlying rocks of the White River group. It is thought that the uranium is held in the lignite as part of a metallo-organic compound.

  4. Potential uranium supply from phosphoric acid: A U.S. analysis comparing solvent extraction and Ion exchange recovery

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kim, Haeyeon; G. Eggert, Roderick; W. Carlsen, Brett

    Phosphate rock contains significant amounts of uranium, although in low concentrations. Recovery of uranium as a by-product from phosphoric acid, an intermediate product produced during the recovery of phosphorus from phosphate rock, is not unprecedented. Phosphoric acid plants ceased to produce uranium as a by-product in the early 1990s with the fall of uranium prices. In the last decade, this topic has regained attention due to higher uranium prices and expected increase in demand for uranium. Our study revisits the topic and estimates how much uranium might be recoverable from current phosphoric acid production in the United States and whatmore » the associated costs might be considering two different recovery processes: solvent extraction and ion exchange. Based on U.S. phosphoric acid production in 2014, 5.5 million pounds of U 3O 8 could have been recovered, more than domestic U.S. mine production of uranium in the same year. Annualized costs for a hypothetical uranium recovery plant are US$48-66 per pound U 3O 8 for solvent extraction, the process used historically in the United States to recover uranium from phosphoric acid. For ion exchange, not yet proven at a commercial scale for uranium recovery, the estimated costs are US$33-54 per pound U 3O 8. Our results suggest that it is technically possible for the United States to recover significant quantities of uranium from current phosphoric acid production. And for this type of uranium production to be economically attractive on a large scale, either recovery costs must fall or uranium prices rise.« less

  5. Potential uranium supply from phosphoric acid: A U.S. analysis comparing solvent extraction and Ion exchange recovery

    DOE PAGES

    Kim, Haeyeon; G. Eggert, Roderick; W. Carlsen, Brett; ...

    2016-06-16

    Phosphate rock contains significant amounts of uranium, although in low concentrations. Recovery of uranium as a by-product from phosphoric acid, an intermediate product produced during the recovery of phosphorus from phosphate rock, is not unprecedented. Phosphoric acid plants ceased to produce uranium as a by-product in the early 1990s with the fall of uranium prices. In the last decade, this topic has regained attention due to higher uranium prices and expected increase in demand for uranium. Our study revisits the topic and estimates how much uranium might be recoverable from current phosphoric acid production in the United States and whatmore » the associated costs might be considering two different recovery processes: solvent extraction and ion exchange. Based on U.S. phosphoric acid production in 2014, 5.5 million pounds of U 3O 8 could have been recovered, more than domestic U.S. mine production of uranium in the same year. Annualized costs for a hypothetical uranium recovery plant are US$48-66 per pound U 3O 8 for solvent extraction, the process used historically in the United States to recover uranium from phosphoric acid. For ion exchange, not yet proven at a commercial scale for uranium recovery, the estimated costs are US$33-54 per pound U 3O 8. Our results suggest that it is technically possible for the United States to recover significant quantities of uranium from current phosphoric acid production. And for this type of uranium production to be economically attractive on a large scale, either recovery costs must fall or uranium prices rise.« less

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    B.R. Westphal; J.C. Price; R.D. Mariani

    The pyroprocessing of used nuclear fuel via electrorefining requires the continued addition of uranium trichloride to sustain operations. Uranium trichloride is utilized as an oxidant in the system to allow separation of uranium metal from the minor actinides and fission products. The inventory of uranium trichloride had diminished to a point that production was necessary to continue electrorefiner operations. Following initial experimentation, cupric chloride was chosen as a reactant with uranium metal to synthesize uranium trichloride. Despite the variability in equipment and charge characteristics, uranium trichloride was produced in sufficient quantities to maintain operations in the electrorefiner. The results andmore » conclusions from several experiments are presented along with a set of optimized operating conditions for the synthesis of uranium trichloride.« less

  7. PYROCHEMICAL DECONTAMINATION METHOD FOR REACTOR FUEL

    DOEpatents

    Buyers, A.G.

    1959-06-30

    A pyro-chemical method is presented for decontaminating neutron irradiated uranium and separating plutonium therefrom by contact in the molten state with a metal chloride salt. Uranium trichloride and uranium tetrachloride either alone or in admixture with alkaline metal and alkaline eanth metal fluorides under specified temperature and specified phase ratio conditions extract substantially all of the uranium from the irradiated uranium fuel together with certain fission products. The phases are then separated leaving purified uranium metal. The uranium and plutonium in the salt phase can be reduced to forin a highly decontaminated uraniumplutonium alloy. The present method possesses advantages for economically decontaminating irradiated nuclear fuel elements since irradiated fuel may be proccessed immediately after withdrawal from the reactor and the uranium need not be dissolved and later reduced to the metallic form. Accordingly, the uranium may be economically refabricated and reinserted into the reactor.

  8. Carbon diffusion in molten uranium: an ab initio molecular dynamics study

    NASA Astrophysics Data System (ADS)

    Garrett, Kerry E.; Abrecht, David G.; Kessler, Sean H.; Henson, Neil J.; Devanathan, Ram; Schwantes, Jon M.; Reilly, Dallas D.

    2018-04-01

    In this work we used ab initio molecular dynamics within the framework of density functional theory and the projector-augmented wave method to study carbon diffusion in liquid uranium at temperatures above 1600 K. The electronic interactions of carbon and uranium were described using the local density approximation (LDA). The self-diffusion of uranium based on this approach is compared with literature computational and experimental results for liquid uranium. The temperature dependence of carbon and uranium diffusion in the melt was evaluated by fitting the resulting diffusion coefficients to an Arrhenius relationship. We found that the LDA calculated activation energy for carbon was nearly twice that of uranium: 0.55 ± 0.03 eV for carbon compared to 0.32 ± 0.04 eV for uranium. Structural analysis of the liquid uranium-carbon system is also discussed.

  9. 40 CFR 471.70 - Applicability; description of the uranium forming subcategory.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... uranium forming subcategory. 471.70 Section 471.70 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORY Uranium Forming Subcategory § 471.70 Applicability; description of the uranium forming... introductions of pollutants into publicly owned treatment works from the process operations of the uranium...

  10. 40 CFR 471.70 - Applicability; description of the uranium forming subcategory.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... uranium forming subcategory. 471.70 Section 471.70 Protection of Environment ENVIRONMENTAL PROTECTION... SOURCE CATEGORY Uranium Forming Subcategory § 471.70 Applicability; description of the uranium forming... introductions of pollutants into publicly owned treatment works from the process operations of the uranium...

  11. The Toxicity of Depleted Uranium

    PubMed Central

    Briner, Wayne

    2010-01-01

    Depleted uranium (DU) is an emerging environmental pollutant that is introduced into the environment primarily by military activity. While depleted uranium is less radioactive than natural uranium, it still retains all the chemical toxicity associated with the original element. In large doses the kidney is the target organ for the acute chemical toxicity of this metal, producing potentially lethal tubular necrosis. In contrast, chronic low dose exposure to depleted uranium may not produce a clear and defined set of symptoms. Chronic low-dose, or subacute, exposure to depleted uranium alters the appearance of milestones in developing organisms. Adult animals that were exposed to depleted uranium during development display persistent alterations in behavior, even after cessation of depleted uranium exposure. Adult animals exposed to depleted uranium demonstrate altered behaviors and a variety of alterations to brain chemistry. Despite its reduced level of radioactivity evidence continues to accumulate that depleted uranium, if ingested, may pose a radiologic hazard. The current state of knowledge concerning DU is discussed. PMID:20195447

  12. Electrochemical method of producing eutectic uranium alloy and apparatus

    DOEpatents

    Horton, James A.; Hayden, H. Wayne

    1995-01-01

    An apparatus and method for continuous production of liquid uranium alloys through the electrolytic reduction of uranium chlorides. The apparatus includes an electrochemical cell formed from an anode shaped to form an electrolyte reservoir, a cathode comprising a metal, such as iron, capable of forming a eutectic uranium alloy having a melting point less than the melting point of pure uranium, and molten electrolyte in the reservoir comprising a chlorine or fluorine containing salt and uranium chloride. The method of the invention produces an eutectic uranium alloy by creating an electrolyte reservoir defined by a container comprising an anode, placing an electrolyte in the reservoir, the electrolyte comprising a chlorine or fluorine containing salt and uranium chloride in molten form, positioning a cathode in the reservoir where the cathode comprises a metal capable of forming an uranium alloy having a melting point less than the melting point of pure uranium, and applying a current between the cathode and the anode.

  13. Geological and geochemical aspects of uranium deposits. A selected, annotated bibliography

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garland, P.A.; Thomas, J.M.; Brock, M.L.

    1980-06-01

    A bibliography of 479 references encompassing the fields of uranium and thorium geochemistry and mineralogy, geology of uranium deposits, uranium mining, and uranium exploration techniques has been compiled by the Ecological Sciences Information Center of Oak Ridge National Laboratory. The bibliography was produced for the National Uranium Resource Evaluation Program, which is funded by the Grand Junction Office of the Department of Energy. The references contained in the bibliography have been divided into the following eight subject categories: (1) geology of deposits, (2) geochemistry, (3) genesis O deposits, (4) exploration, (5) mineralogy, (6) uranium industry, (7) reserves and resources, andmore » (8) geology of potential uranium-bearing areas. All categories specifically refer to uranium and thorium; the last category contains basic geologic information concerning areas which the Grand Junction Office feels are particularly favorable for uranium deposition. The references are indexed by author, geographic location, quadrangle name, geoformational feature, taxonomic name, and keyword.« less

  14. Electrochemical method of producing eutectic uranium alloy and apparatus

    DOEpatents

    Horton, J.A.; Hayden, H.W.

    1995-01-10

    An apparatus and method are disclosed for continuous production of liquid uranium alloys through the electrolytic reduction of uranium chlorides. The apparatus includes an electrochemical cell formed from an anode shaped to form an electrolyte reservoir, a cathode comprising a metal, such as iron, capable of forming a eutectic uranium alloy having a melting point less than the melting point of pure uranium, and molten electrolyte in the reservoir comprising a chlorine or fluorine containing salt and uranium chloride. The method of the invention produces an eutectic uranium alloy by creating an electrolyte reservoir defined by a container comprising an anode, placing an electrolyte in the reservoir, the electrolyte comprising a chlorine or fluorine containing salt and uranium chloride in molten form, positioning a cathode in the reservoir where the cathode comprises a metal capable of forming an uranium alloy having a melting point less than the melting point of pure uranium, and applying a current between the cathode and the anode. 2 figures.

  15. Conversion of depleted uranium hexafluoride to a solid uranium compound

    DOEpatents

    Rothman, Alan B.; Graczyk, Donald G.; Essling, Alice M.; Horwitz, E. Philip

    2001-01-01

    A process for converting UF.sub.6 to a solid uranium compound such as UO.sub.2 and CaF. The UF.sub.6 vapor form is contacted with an aqueous solution of NH.sub.4 OH at a pH greater than 7 to precipitate at least some solid uranium values as a solid leaving an aqueous solution containing NH.sub.4 OH and NH.sub.4 F and remaining uranium values. The solid uranium values are separated from the aqueous solution of NH.sub.4 OH and NH.sub.4 F and remaining uranium values which is then diluted with additional water precipitating more uranium values as a solid leaving trace quantities of uranium in a dilute aqueous solution. The dilute aqueous solution is contacted with an ion-exchange resin to remove substantially all the uranium values from the dilute aqueous solution. The dilute solution being contacted with Ca(OH).sub.2 to precipitate CaF.sub.2 leaving dilute NH.sub.4 OH.

  16. The adsorption of methyl iodide on uranium and uranium dioxide: Surface characterization using X-ray photoelectron spectroscopy (XPS) and Auger electron spectroscopy (AES)

    NASA Astrophysics Data System (ADS)

    Dillard, J. G.; Moers, H.; Klewe-Nebenius, H.; Kirch, G.; Pfennig, G.; Ache, H. J.

    1984-09-01

    The adsorption of methyl iodide on uranium and on uranium dioxide has been studied at 25 °C. Surfaces of the substrates were characterized before and after adsorption by X-ray photoelectron spectroscopy (XPS) and Auger electron spectroscopy (AES). The XPS binding energy results indicate that CH 3I adsorption on uranium yields a carbide-type carbon, UC, and uranium iodide, UI 3. On uranium dioxide the carbon electron binding energy measurements are consistent with the formation of a hydrocarbon, —CH 3-type moiety. The interpretation of XPS and AES spectral features for CH 3I adsorption on uranium suggest that a complex dissociative adsorption reaction takes place. Adsorption of CH 3I on UO 2 occurs via a dissociative process. Saturation coverage occurs on uranium at approximately two langmuir (1 L = 10 -6 Torr s) exposure whereas saturation coverage on uranium dioxide is found at about five langmuir.

  17. Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.

    PubMed Central

    Hirayama, Y.; Lei, Y. H.; Barnes, P. J.; Rogers, D. F.

    1993-01-01

    1. We compared the effects of two novel tachykinin receptor antagonists, FK888 (selective at the tachykinin NK1 receptor) and FK224 (dual antagonist at NK1 and NK2 tachykinin receptors) on stimulus-evoked airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo. Plasma exudation was induced by substance P (SP), synthetic tachykinin receptor agonists, platelet activating factor (PAF), electrical stimulation of the cervical vagus nerves or by inhalation of cigarette smoke. Changes in airway tone and in carotid artery blood pressure (BP) were induced by synthetic tachykinin agonists, PAF and vagal stimulation. 2. Both FK224 and FK888 dose-dependently inhibited SP-induced plasma exudation in the lower trachea and main bronchi (ID50 values respectively of 1.1 and 0.1 mumol kg-1 in lower trachea, and of 0.5 and 0.1 mumol kg-1 in main bronchi) with complete inhibition at both airway levels at 10 mumol kg-1 for FK224 and at 2 mumol kg-1 for FK888. 3. The NK1-selective tachykinin receptor agonist, [Sar9,Met(O2)11]substance P ([Sar]SP), induced plasma exudation, a response which was blocked by both FK888 and FK224. The NK2-selective agonist, [beta-Ala8]neurokinin A-(4-10) ([beta-Ala]NKA), did not induce plasma exudation: neither FK888 nor FK224 affected this lack of response to [beta-Ala]NKA. 4. [beta-Ala]NKA induced bronchoconstriction, a response which was blocked by FK224 but which was completely unaffected by FK888. [Sar]SP induced a small but significant bronchoconstriction which was completely inhibited by both tachykinin antagonists. 5. In animals pretreated with capsaicin to deplete sensory neuropeptides, PAF induced both plasma exudation and bronchoconstriction.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7682142

  18. Maps showing the distribution of uranium-deposit clusters in the Colorado Plateau uranium province

    USGS Publications Warehouse

    Finch, Warren I.

    1991-01-01

    The Colorado Palteau Uranium Province (CPUP) is defined by the distribution of uranium deposits, chiefly the sandstone-type, in upper Paleozoic and Mesozoic sedimentary rocks within the Colorado Plateau physiographic province (Granger and others, 1986).  The uranium province is bordered by widely distributed and mostly minor uranium deposits in Precambrian and Tertiary rocks and by outcrops of Tertiary extrusive and intrusive igneous rocks.  

  19. Uranium in bone: metabolic and autoradiographic studies in the rat.

    PubMed

    Priest, N D; Howells, G R; Green, D; Haines, J W

    1982-03-01

    The distribution and retention of intravenously injected hexavalent uranium-233 in the skeleton of the female rat has been investigated using a variety of autoradiographic and radiochemical techniques. These showed that approximately one third of the injected uranium is deposited in the skeleton where it is retained with an initial biological half-time of approximately 40 days. The studies also showed that: 1 Uranium is initially deposited onto all types of bone surface, but preferentially onto those that are accreting. 2 Uranium is deposited in the calcifying zones of skeletal cartilage. 3 Bone accretion results in the burial of surface deposits of uranium. 4 Bone resorption causes the removal of uranium from surfaces. 5 Resorbed uranium is not retained by osteoclasts and macrophages in the bone marrow. 6 Uranium removed from bone surfaces enters the bloodstream where most is either redeposited in bone or excreted via the kidneys. 7 The recycling of resorbed uranium within the skeleton tends to produce a uniform level of uranium contamination throughout mineralized bone. These results are taken to indicate that uranium deposition in bone shares characteristics in common with both the 'volume-seeking radionuclides' typified by the alkaline earth elements and with the 'bone surface-seeking radionuclides' typified by plutonium.

  20. Process for producing enriched uranium having a .sup.235 U content of at least 4 wt. % via combination of a gaseous diffusion process and an atomic vapor laser isotope separation process to eliminate uranium hexafluoride tails storage

    DOEpatents

    Horton, James A.; Hayden, Jr., Howard W.

    1995-01-01

    An uranium enrichment process capable of producing an enriched uranium, having a .sup.235 U content greater than about 4 wt. %, is disclosed which will consume less energy and produce metallic uranium tails having a lower .sup.235 U content than the tails normally produced in a gaseous diffusion separation process and, therefore, eliminate UF.sub.6 tails storage and sharply reduce fluorine use. The uranium enrichment process comprises feeding metallic uranium into an atomic vapor laser isotope separation process to produce an enriched metallic uranium isotopic mixture having a .sup.235 U content of at least about 2 wt. % and a metallic uranium residue containing from about 0.1 wt. % to about 0.2 wt. % .sup.235 U; fluorinating this enriched metallic uranium isotopic mixture to form UF.sub.6 ; processing the resultant isotopic mixture of UF.sub.6 in a gaseous diffusion process to produce a final enriched uranium product having a .sup.235 U content of at least 4 wt. %, and up to 93.5 wt. % or higher, of the total uranium content of the product, and a low .sup.235 U content UF.sub.6 having a .sup.235 U content of about 0.71 wt. % of the total uranium content of the low .sup.235 U content UF.sub.6 ; and converting this low .sup.235 U content UF.sub.6 to metallic uranium for recycle to the atomic vapor laser isotope separation process.

  1. Process for producing enriched uranium having a {sup 235}U content of at least 4 wt. % via combination of a gaseous diffusion process and an atomic vapor laser isotope separation process to eliminate uranium hexafluoride tails storage

    DOEpatents

    Horton, J.A.; Hayden, H.W. Jr.

    1995-05-30

    An uranium enrichment process capable of producing an enriched uranium, having a {sup 235}U content greater than about 4 wt. %, is disclosed which will consume less energy and produce metallic uranium tails having a lower {sup 235}U content than the tails normally produced in a gaseous diffusion separation process and, therefore, eliminate UF{sub 6} tails storage and sharply reduce fluorine use. The uranium enrichment process comprises feeding metallic uranium into an atomic vapor laser isotope separation process to produce an enriched metallic uranium isotopic mixture having a {sup 235} U content of at least about 2 wt. % and a metallic uranium residue containing from about 0.1 wt. % to about 0.2 wt. % {sup 235} U; fluorinating this enriched metallic uranium isotopic mixture to form UF{sub 6}; processing the resultant isotopic mixture of UF{sub 6} in a gaseous diffusion process to produce a final enriched uranium product having a {sup 235}U content of at least 4 wt. %, and up to 93.5 wt. % or higher, of the total uranium content of the product, and a low {sup 235}U content UF{sub 6} having a {sup 235}U content of about 0.71 wt. % of the total uranium content of the low {sup 235}U content UF{sub 6}; and converting this low {sup 235}U content UF{sub 6} to metallic uranium for recycle to the atomic vapor laser isotope separation process. 4 figs.

  2. 30 CFR 285.224 - What happens if MMS accepts my bid?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER CONTINENTAL SHELF Issuance of OCS Renewable Energy Leases Competitive Lease Award Process § 285.224 What happens if MMS accepts my bid? If we...

  3. 14 CFR 13.224 - Burden of proof.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.224 Burden of proof... otherwise provided by statute or rule, the proponent of a motion, request, or order has the burden of proof...

  4. 49 CFR Appendix A to Part 224 - Schedule of Civil Penalties1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... § 224.105Sheeting dimensions and quantity: Failure to apply minimum amount of retroreflective sheeting in accordance with Table 2 2,500 5,000 Applying retroreflective sheeting of wrong dimensions 2,500 5...

  5. 49 CFR 224.5 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.5 Definitions. Administrator means the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

  6. 49 CFR 224.5 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.5 Definitions. Administrator means the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

  7. 49 CFR 224.5 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.5 Definitions. Administrator means the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

  8. Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy.

    PubMed

    Piotrowska, Agata; Leszczuk, Edyta; Bruchertseifer, Frank; Morgenstern, Alfred; Bilewicz, Aleksander

    2013-01-01

    The 223 Ra, 224 Ra, and 225 Ra radioisotopes exhibit very attractive nuclear properties for application in radionuclide therapy. Unfortunately the lack of appropriate bifunctional ligand for radium is the reason why these radionuclides have not found application in receptor-targeted therapy. In the present work, the potential usefulness of the NaA nanozeolite as a carrier for radium radionuclides has been studied. 224 Ra and 225 Ra, α-particle emitting radionuclides, have been absorbed in the nanometer-sized NaA zeolite (30-70 nm) through simple ion exchange. 224,225 Ra-nanozeolites exhibited very high stability in solutions containing physiological salt, EDTA, amino acids, and human serum. To make NaA nanozeolite particles dispersed in water their surface was modified with a silane coupling agent containing poly(ethylene glycol) molecules. This functionalization approach let us covalently attach a biomolecule to the NaA nanozeolite surface.

  9. The importance of colloids and mires for the transport of uranium isotopes through the Kalix River watershed and Baltic Sea

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Porcelli, D.; Wasserburg, G.J.; Andersson, P.S.

    The importance of colloids and organic deposits for the transport of uranium isotopes from continental source regions and through the estuarine environment was investigated in the mire-rich Kalix River drainage basin in northern Sweden and the Baltic Sea. Ultrafiltration techniques were used to separate uranium and other elements associated with colloids > 10 kD and >3 kD from {open_quotes}solute{close_quotes} uranium and provided consistent results and high recovery rates for uranium as well as for other elements from large volume samples. Uranium concentrations in 0.45 {mu}m-filtered Kalix River water samples increased by a factor of 3 from near the headwaters inmore » the Caledonides to the river mouth while major cation concentrations were relatively constant. {sup 234}U {sup 238}U ratios were high ({delta}{sup 234}U = 770-1500) throughout the basin, without showing any simple pattern, and required a supply of {sup 234}U-rich water. Throughout the Kalix River, a large fraction (30-90%) of the uranium is carried by >10 kD colloids, which is compatible with uranium complexation with humic acids. No isotopic differences were found between colloid-associated and solute uranium. Within the Baltic Sea, about half of the uranium is removed at low salinities. The proportion that is lost is equivalent to that of river-derived colloid-bound uranium, suggesting that while solute uranium behaves conservatively during estuarine mixing, colloid-bound uranium is lost due to rapid flocculation of colloidal material. The association of uranium with colloids therefore may be an important parameter in determining uranium estuarine behavior. Mire peats in the Kalix River highly concentrate uranium and are potentially a significant source of recoil {sup 234}U to the mirewaters and river waters. However, mirewater data clearly demonstrate that only small {sup 234}U/{sup 238}U shifts are generated relative to inflowing groundwater. 63 refs., 8 figs., 3 tabs.« less

  10. Uranium hydrogeochemical and stream sediment reconnaissance of the Albuquerque NTMS Quadrangle, New Mexico, including concentrations of forty-three additional elements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Maassen, L.W.; Bolivar, S.L.

    1979-06-01

    The Los Alamos Scientific Laboratory conducted a hydrogeochemical and stream sediment reconnaissance for uranium. Totals of 408 water and 1538 sediment samples were collected from 1802 locations over a 20 100-km/sup 2/ area at an average density of one location per 11 km/sup 2/. Water samples were collected from springs, wells, and streams; sediments samples were collected predominantly from streams, but also from springs. All water samples were analyzed for uranium and 12 other elements. Sediment samples were analyzed for uranium and 42 additional elements. The uranium concentrations in water samples range from below the detection limit of 0.02 ppBmore » to 194.06 ppB. The mean uranium concentration for all water types containing < 40 ppB uranium is 1.98 ppB. Six samples contained uranium concentrations > 40.00 ppB. Well waters have the highest mean uranium concentration; spring waters have the lowest. Clusters of water samples that contain anomalous uranium concentrations are delineated in nine areas. Sediments collected from the quadrangle have uranium concentrations that range between 0.63 ppM and 28.52 ppM, with a mean for all sediments of 3.53 ppM. Eight areas containing clusters of sediments with anomalous uranium concentrations are delineated. One cluster contains sample locations within the Ambrosia Lake uranium district. Five clusters of sediment samples with anomalous uranium concentrations were collected from streams that drain the Jemez volcanic field. Another cluster defines an area just northeast of Albuquerque where streams drain Precambrian rocks, predominantly granites, of the Sandia Mountains. The last cluster, consisting of spring sediments from Mesa Portales, was collected near the contact of the Tertiary Ojo Alamo sandstone with underlying Cretaceous sediments. Sediments from these springs exhibit some of the highest uranium values reported and are associated with high uranium/thorium ratios.« less

  11. 31 CFR 540.318 - Uranium Hexafluoride (UF6).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Uranium Hexafluoride (UF6). 540.318... OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.318 Uranium Hexafluoride (UF6). The term uranium...

  12. 49 CFR 173.426 - Excepted packages for articles containing natural uranium or thorium.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... uranium or thorium. 173.426 Section 173.426 Transportation Other Regulations Relating to Transportation....426 Excepted packages for articles containing natural uranium or thorium. A manufactured article in which the sole Class 7 (radioactive) material content is natural uranium, unirradiated depleted uranium...

  13. 31 CFR 540.318 - Uranium Hexafluoride (UF6).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Uranium Hexafluoride (UF6). 540.318... OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.318 Uranium Hexafluoride (UF6). The term uranium...

  14. 31 CFR 540.318 - Uranium Hexafluoride (UF6).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Uranium Hexafluoride (UF6). 540.318... OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.318 Uranium Hexafluoride (UF6). The term uranium...

  15. 31 CFR 540.316 - Uranium enrichment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Uranium enrichment. 540.316 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.316 Uranium enrichment. The term uranium enrichment means the process of...

  16. 31 CFR 540.318 - Uranium Hexafluoride (UF6).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Uranium Hexafluoride (UF6). 540.318... OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.318 Uranium Hexafluoride (UF6). The term uranium...

  17. 31 CFR 540.316 - Uranium enrichment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Uranium enrichment. 540.316 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.316 Uranium enrichment. The term uranium enrichment means the process of...

  18. 31 CFR 540.316 - Uranium enrichment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Uranium enrichment. 540.316 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.316 Uranium enrichment. The term uranium enrichment means the process of...

  19. 49 CFR 173.426 - Excepted packages for articles containing natural uranium or thorium.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... uranium or thorium. 173.426 Section 173.426 Transportation Other Regulations Relating to Transportation....426 Excepted packages for articles containing natural uranium or thorium. A manufactured article in which the sole Class 7 (radioactive) material content is natural uranium, unirradiated depleted uranium...

  20. 31 CFR 540.316 - Uranium enrichment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Uranium enrichment. 540.316 Section... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.316 Uranium enrichment. The term uranium enrichment means the process of...

  1. 49 CFR 173.426 - Excepted packages for articles containing natural uranium or thorium.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... uranium or thorium. 173.426 Section 173.426 Transportation Other Regulations Relating to Transportation....426 Excepted packages for articles containing natural uranium or thorium. A manufactured article in which the sole Class 7 (radioactive) material content is natural uranium, unirradiated depleted uranium...

  2. 31 CFR 540.318 - Uranium Hexafluoride (UF6).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Uranium Hexafluoride (UF6). 540.318... OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY HIGHLY ENRICHED URANIUM (HEU) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.318 Uranium Hexafluoride (UF6). The term uranium...

  3. 31 CFR 540.309 - Natural uranium.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Natural uranium. 540.309 Section 540.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... REGULATIONS General Definitions § 540.309 Natural uranium. The term natural uranium means uranium found in...

  4. 31 CFR 540.309 - Natural uranium.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Natural uranium. 540.309 Section 540.309 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF... REGULATIONS General Definitions § 540.309 Natural uranium. The term natural uranium means uranium found in...

  5. THE RECOVERY OF URANIUM FROM GAS MIXTURE

    DOEpatents

    Jury, S.H.

    1964-03-17

    A method of separating uranium from a mixture of uranium hexafluoride and other gases is described that comprises bringing the mixture into contact with anhydrous calcium sulfate to preferentially absorb the uranium hexafluoride on the sulfate. The calcium sulfate is then leached with a selective solvent for the adsorbed uranium. (AEC)

  6. PREPARATION OF URANIUM-ALUMINUM ALLOYS

    DOEpatents

    Moore, R.H.

    1962-09-01

    A process is given for preparing uranium--aluminum alloys from a solution of uranium halide in an about equimolar molten alkali metal halide-- aluminum halide mixture and excess aluminum. The uranium halide is reduced and the uranium is alloyed with the excess aluminum. The alloy and salt are separated from each other. (AEC)

  7. Separation of uranium from (Th,U)O.sub.2 solid solutions

    DOEpatents

    Chiotti, Premo; Jha, Mahesh Chandra

    1976-09-28

    Uranium is separated from mixed oxides of thorium and uranium by a pyrometallurgical process in which the oxides are mixed with a molten chloride salt containing thorium tetrachloride and thorium metal which reduces the uranium oxide to uranium metal which can then be recovered from the molten salt. The process is particularly useful for the recovery of uranium from generally insoluble high-density sol-gel thoria-urania nuclear reactor fuel pellets.

  8. PROCESS FOR SEGREGATING URANIUM FROM PLUTONIUM AND FISSION-PRODUCT CONTAMINATION

    DOEpatents

    Ellison, C.V.; Runion, T.C.

    1961-06-27

    An aqueous nitric acid solution containing uranium, plutonium, and fission product values is contacted with an organic extractant comprised of a trialkyl phosphate and an organic diluent. The relative amounts of trialkyl phosphate and uranium values are controlled to achieve a concentration of uranium values in the organic extractant of at least 0.35 moles uranium per mole of trialkyl phosphate, thereby preferentially extracting uranium values into the organic extractant.

  9. URANIUM RECOVERY PROCESS

    DOEpatents

    Bailes, R.H.; Long, R.S.; Olson, R.S.; Kerlinger, H.O.

    1959-02-10

    A method is described for recovering uranium values from uranium bearing phosphate solutions such as are encountered in the manufacture of phosphate fertilizers. The solution is first treated with a reducing agent to obtain all the uranium in the tetravalent state. Following this reduction, the solution is treated to co-precipitate the rcduced uranium as a fluoride, together with other insoluble fluorides, thereby accomplishing a substantially complete recovery of even trace amounts of uranium from the phosphate solution. This precipitate usually takes the form of a complex fluoride precipitate, and after appropriate pre-treatment, the uranium fluorides are leached from this precipitate and rccovered from the leach solution.

  10. Carbon diffusion in molten uranium: an ab initio molecular dynamics study

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Garrett, Kerry E.; Abrecht, David G.; Kessler, Sean H.

    In this work we used ab initio molecular dynamics (AIMD) within the framework of density functional theory (DFT) and the projector-augmented wave (PAW) method to study carbon diffusion in liquid uranium at temperatures above 1600 K. The electronic interactions of carbon and uranium were described using the local density approximation (LDA). The self-diffusion of uranium based on this approach is compared with literature computational and experimental results for liquid uranium. The temperature dependence of carbon and uranium diffusion in the melt was evaluated by fitting the resulting diffusion coefficients to an Arrhenius relationship. We found that the LDA calculated activationmore » energy for carbon was nearly twice that of uranium: 0.55±0.03 eV for carbon compared to 0.32±0.04 eV for uranium. Structural analysis of the liquid uranium-carbon system is also discussed.« less

  11. Absorption of Thermal Neutrons in Uranium

    DOE R&D Accomplishments Database

    Creutz, E. C.; Wilson, R. R.; Wigner, E. P.

    1941-09-26

    A knowledge of the absorption processes for neutrons in uranium is important for planning a chain reaction experiment. The absorption of thermal neutrons in uranium and uranium oxide has been studied. Neutrons from the cyclotron were slowed down by passage through a graphite block. A uranium or uranium oxide sphere was placed at various positions in the block. The neutron intensity at different points in the sphere and in the graphite was measured by observing the activity induced in detectors or uranium oxide or manganese. It was found that both the fission activity in the uranium oxide and the activity induced in manganese was affected by non-thermal neutrons. An experimental correction for such effects was made by making measurements with the detectors surrounded by cadmium. After such corrections the results from three methods of procedure with the uranium oxide detectors and from the manganese detectors were consistent to within a few per cent.

  12. Process for producing an aggregate suitable for inclusion into a radiation shielding product

    DOEpatents

    Lessing, Paul A.; Kong, Peter C.

    2000-01-01

    The present invention is directed to methods for converting depleted uranium hexafluoride to a stable depleted uranium silicide in a one-step reaction. Uranium silicide provides a stable aggregate material that can be added to concrete to increase the density of the concrete and, consequently, shield gamma radiation. As used herein, the term "uranium silicide" is defined as a compound generically having the formula U.sub.x Si.sub.y, wherein the x represents the molecules of uranium and the y represent the molecules of silicon. In accordance with the present invention, uranium hexafluoride is converted to a uranium silicide by contacting the uranium hexafluoride with a silicon-containing material at a temperature in a range between about 1450.degree. C. and about 1750.degree. C. The stable depleted uranium silicide is included as an aggregate in a radiation shielding product, such as a concrete product.

  13. Fermentation and Hydrogen Metabolism Affect Uranium Reduction by Clostridia

    DOE PAGES

    Gao, Weimin; Francis, Arokiasamy J.

    2013-01-01

    Previously, it has been shown that not only is uranium reduction under fermentation condition common among clostridia species, but also the strains differed in the extent of their capability and the pH of the culture significantly affected uranium(VI) reduction. In this study, using HPLC and GC techniques, metabolic properties of those clostridial strains active in uranium reduction under fermentation conditions have been characterized and their effects on capability variance of uranium reduction discussed. Then, the relationship between hydrogen metabolism and uranium reduction has been further explored and the important role played by hydrogenase in uranium(VI) and iron(III) reduction by clostridiamore » demonstrated. When hydrogen was provided as the headspace gas, uranium(VI) reduction occurred in the presence of whole cells of clostridia. This is in contrast to that of nitrogen as the headspace gas. Without clostridia cells, hydrogen alone could not result in uranium(VI) reduction. In alignment with this observation, it was also found that either copper(II) addition or iron depletion in the medium could compromise uranium reduction by clostridia. In the end, a comprehensive model was proposed to explain uranium reduction by clostridia and its relationship to the overall metabolism especially hydrogen (H 2 ) production.« less

  14. Incorporation of Uranium: II. Distribution of Uranium Absorbed through the Lungs and the Skin

    PubMed Central

    Walinder, G.; Fries, B.; Billaudelle, U.

    1967-01-01

    In experiments on mice, rabbits, and piglets the distribution of uranium was studied at different times after exposure. Uranium was administered by inhalation (mice) and through the skin (rabbits and piglets). These investigations show that the uptakes of uranium in different organs of the three species are highly dependent on the amounts administered. There seems to be a saturation effect in the spleen and bone tissue whenever the uranium concentration in the blood exceeds a certain level. The effect in the kidney is completely different. If, in a series of animals, the quantity of uranium is continuously increased, the uptakes by the kidneys increase more rapidly than the quantities administered. This observation seems to be consistent with the toxic effects of uranium on the capillary system in the renal cortex. Polyphloretin phosphate, a compound which reduces permeability, was investigated with respect to its effect on the uptake of uranium deposited in skin wounds in rabbits and piglets. It significantly reduced the absorption of uranium, even from depots in deep wounds. The findings are discussed with reference to the routine screening of persons exposed to uranium at AB Atomenergi. Images PMID:6073090

  15. Rapid Dissolution of Soluble Uranyl Phases in Arid, Mine-Impacted Catchments Near Church Rock, NM

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    deLemos, J.L.; Bostick, B.C.; Quicksall, A.N.

    2009-05-14

    We tested the hypothesis that runoff of uranium-bearing particles from mining waste disposal areas was a significant mechanism for redistribution of uranium in the northeastern part of the Upper Puerco River watershed (New Mexico). However, our results were not consistent with this hypothesis. Analysis of >100 sediment and suspended sediment samples collected adjacent to and downstream from uranium source areas indicated that uranium levels in the majority of the samples were not elevated above background. Samples collected within 50 m of a known waste disposal site were subjected to detailed geochemical characterization. Uranium in these samples was found to bemore » highly soluble; treatment with synthetic pore water for 24 h caused dissolution of 10-50% of total uranium in the samples. Equilibrium uranium concentrations in pore water were >4.0 mg/L and were sustained in repeated wetting events, effectively depleting soluble uranium from the solid phase. The dissolution rate of uranium appeared to be controlled by solid-phase diffusion of uranium from within uranium-bearing mineral particles. X-ray adsorption spectroscopy indicated the presence of a soluble uranyl silicate, and possibly a uranyl phosphate. These phases were exhausted in transported sediment suggesting that uranium was readily mobilized from sediments in the Upper Puerco watershed and transported in the dissolved load. These results could have significance for uranium risk assessment as well as mining waste management and cleanup efforts.« less

  16. Comparison of the Kinetic Rate Law Parameters for the Dissolution of Natural and Synthetic Autunite in the Presence of Aqueous Bicarbonate Ions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gudavalli, Ravi; Katsenovich, Yelena; Wellman, Dawn M.

    2013-08-02

    Bicarbonate is one of the most significant components within the uranium geochemical cycle. In aqueous solutions, bicarbonate forms strong complexes with uranium. As such, aqueous bicarbonate may significantly increase the rate of uranium release from uranium minerals. Quantifying the relationship of aqueous bicarbonate concentration to the rate of uranium release during dissolution is critical to understanding the long-term fate of uranium within the environment. Single-pass flow-through (SPTF) experiments were conducted to estimate the rate of uranium release from Na meta-autunite as a function of bicarbonate (0.0005-0.003 M) under the pH range of 6-11 and a temperature range of 5-60oC. Consistentmore » with the results of previous investigation, the rate of uranium release exhibited minimal dependency on temperature; but were strongly dependent on pH. Increasing aqueous bicarbonate concentrations afforded comparable increases in the rate of release of uranium. Most notably under low pH conditions the aqueous bicarbonate resulted in up to 370 fold increases in the rate of uranium release in relative to the rate of uranium release in the absence of bicarbonate. However, the effect of aqueous bicarbonate on the release of uranium was significantly less under higher pH conditions. It is postulated that at high pH values, surface sites are saturated with carbonate, thus the addition of more bicarbonate would have less effect on uranium release.« less

  17. Rapid Dissolution of Soluble Uranyl Phases in Arid, Mine-Impacted Catchments near Church Rock, NM

    PubMed Central

    DELEMOS, JAMIE L.; BOSTICK, BENJAMIN C.; QUICKSALL, ANDREW N.; LANDIS, JOSHUA D.; GEORGE, CHRISTINE C.; SLAGOWSKI, NAOMI L.; ROCK, TOMMY; BRUGGE, DOUG; LEWIS, JOHNNYE; DURANT, JOHN L.

    2008-01-01

    We tested the hypothesis that runoff of uranium-bearing particles from mining waste disposal areas was a significant mechanism for redistribution of uranium in the northeastern part of the Upper Puerco River watershed (New Mexico). However, our results were not consistent with this hypothesis. Analysis of >100 sediment and suspended sediment samples collected adjacent to and downstream from uranium source areas indicated that uranium levels in the majority of the samples were not elevated above background. Samples collected within 50 m of a known waste disposal site were subjected to detailed geochemical characterization. Uranium in these samples was found to be highly soluble; treatment with synthetic pore water for 24 h caused dissolution of 10–50% of total uranium in the samples. Equilibrium uranium concentrations in pore water were >4.0 mg/L and were sustained in repeated wetting events, effectively depleting soluble uranium from the solid phase. The dissolution rate of uranium appeared to be controlled by solid-phase diffusion of uranium from within uranium-bearing mineral particles. X-ray adsorption spectroscopy indicated the presence of a soluble uranyl silicate, and possibly a uranyl phosphate. These phases were exhausted in transported sediment suggesting that uranium was readily mobilized from sediments in the Upper Puerco watershed and transported in the dissolved load. These results could have significance for uranium risk assessment as well as mining waste management and cleanup efforts. PMID:18589950

  18. Biosorption of uranium by Pseudomonas aeruginosa strain CSU: Characterization and comparison studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hu, M.Z.C.; Norman, J.M.; Faison, B.D.

    1996-07-20

    Pseudomonas aeruginosa strain CSU, a nongenetically engineered bacterial strain known to bind dissolved hexavalent uranium (as UO{sub 2}{sup 2+} and/or its cationic hydroxo complexes) was characterized with respect to its sorptive activity. The uranium biosorption equilibrium could be described by the Langmuir isotherm. The rate of uranium adsorption increased following permeabilization of the outer and/or cytoplasmic membrane by organic solvents such as acetone. P. aeruginosa CSU biomass was significantly more sorptive toward uranium than certain novel, patented biosorbents derived from algal or fungal biomass sources. P. aeruginosa CSU biomass was also competitive with commercial cation-exchange resins, particularly in the presencemore » of dissolved transition metals. Uranium binding by P. aeruginosa CSU was clearly pH dependent. Uranium loading capacity increased with increasing pH under acidic conditions, presumably as a function of uranium speciation and due to the H{sup +} competition at some binding sites. Nevertheless, preliminary evidence suggests that this microorganism is also capable of binding anionic hexavalent uranium complexes. Ferric iron was a strong inhibitor of uranium binding to P. aeruginosa CSU biomass, and the presence of uranium also decreased the Fe{sup 3+} loading when the biomass was not saturated with Fe{sup 3+}. Thus, a two-state process in which iron and uranium are removed in consecutive steps was proposed for efficient use of the biomass as a biosorbent in uranium removal from mine wastewater, especially acidic leachates.« less

  19. Urinary excretion of uranium in adult inhabitants of the Czech Republic.

    PubMed

    Malátová, Irena; Bečková, Věra; Kotík, Lukáš

    2016-02-01

    The main aim of this study was to determine and evaluate urinary excretion of uranium in the general public of the Czech Republic. This value should serve as a baseline for distinguishing possible increase in uranium content in population living near legacy sites of mining and processing uranium ores and also to help to distinguish the proportion of the uranium content in urine among uranium miners resulting from inhaled dust. The geometric mean of the uranium concentration in urine of 74 inhabitants of the Czech Republic was 0.091 mBq/L (7.4 ng/L) with the 95% confidence interval 0.071-0.12 mBq/L (5.7-9.6 ng/L) respectively. The geometric mean of the daily excretion was 0.15 mBq/d (12.4 ng/d) with the 95% confidence interval 0.12-0.20 mBq/d (9.5-16.1 ng/d) respectively. Despite the legacy of uranium mines and plants processing uranium ore in the Czech Republic, the levels of uranium in urine and therefore, also human body content of uranium, is similar to other countries, esp. Germany, Slovenia and USA. Significant difference in the daily urinary excretion of uranium was found between individuals using public supply and private water wells as a source of drinking water. Age dependence of daily urinary excretion of uranium was not found. Mean values and their range are comparable to other countries, esp. Germany, Slovenia and USA. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Challenges dealing with depleted uranium in Germany - Reuse or disposal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moeller, Kai D.

    2007-07-01

    During enrichment large amounts of depleted Uranium are produced. In Germany every year 2.800 tons of depleted uranium are generated. In Germany depleted uranium is not classified as radioactive waste but a resource for further enrichment. Therefore since 1996 depleted Uranium is sent to ROSATOM in Russia. However it still has to be dealt with the second generation of depleted Uranium. To evaluate the alternative actions in case a solution has to be found in Germany, several studies have been initiated by the Federal Ministry of the Environment. The work that has been carried out evaluated various possibilities to dealmore » with depleted uranium. The international studies on this field and the situation in Germany have been analyzed. In case no further enrichment is planned the depleted uranium has to be stored. In the enrichment process UF{sub 6} is generated. It is an international consensus that for storage it should be converted to U{sub 3}O{sub 8}. The necessary technique is well established. If the depleted Uranium would have to be characterized as radioactive waste, a final disposal would become necessary. For the planned Konrad repository - a repository for non heat generating radioactive waste - the amount of Uranium is limited by the licensing authority. The existing license would not allow the final disposal of large amounts of depleted Uranium in the Konrad repository. The potential effect on the safety case has not been roughly analyzed. As a result it may be necessary to think about alternatives. Several possibilities for the use of depleted uranium in the industry have been identified. Studies indicate that the properties of Uranium would make it useful in some industrial fields. Nevertheless many practical and legal questions are open. One further option may be the use as shielding e.g. in casks for transport or disposal. Possible techniques for using depleted Uranium as shielding are the use of the metallic Uranium as well as the inclusion in concrete. Another possibility could be the use of depleted uranium for the blending of High enriched Uranium (HEU) or with Plutonium to MOX-elements. (authors)« less

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