Geometric validation of a mobile laser scanning system for urban applications

NASA Astrophysics Data System (ADS)

Guan, Haiyan; Li, Jonathan; Yu, Yongtao; Liu, Yan

2016-03-01

Mobile laser scanning (MLS) technologies have been actively studied and implemented over the past decade, as their application fields are rapidly expanding and extending beyond conventional topographic mapping. Trimble's MX-8, as one of the MLS systems in the current market, generates rich survey-grade laser and image data for urban surveying. The objective of this study is to evaluate whether Trimble MX-8 MLS data satisfies the accuracy requirements of urban surveying. According to the formula of geo-referencing, accuracies of navigation solution and laser scanner determines the accuracy of the collected LiDAR point clouds. Two test sites were selected to test the performance of Trimble MX-8. Those extensive tests confirm that Trimble MX-8 offers a very promising tool to survey complex urban areas.

BRCA1/BARD1 Complex Interacts with Steroidogenic Factor 1----a Potential Mechanism for Regulation of Aromatase Expression by BRCA1

PubMed Central

Lu, Yunzhe; Kang, Tao; Hu, Yanfen

2010-01-01

Germline mutations in BRCA1 predispose women to early onset of breast and ovarian cancers. Findings from previous studies support the notion that the tissue- and gender-specific tumor suppression function of BRCA1 is associated with its role in negative regulation of aromatase expression, the rate-limiting step in estrogen biosynthesis. The molecular mechanism of BRCA1 in regulating aromatase promoter activity remains to be elucidated. In this study, we demonstrate that, in an ovarian granulosa cell line KGN, steroidogenic factor 1 (SF-1) is required for aromatase PII promoter basal activity as well as the elevated aromatase expression mediated by BRCA1 knockdown. Furthermore, BRCA1 in KGN cells exists mainly as a heterodimer with BARD1. We provide evidence that the BRCA1/BARD1 complex interacts with SF-1 both in vivo and in vitro. However, the intrinsic ubiquitin E3 ligase activity of BRCA1/BARD1 does not appear to contribute to ubiquitynation of SF-1. We propose that the interaction between SF-1 and BRCA1/BARD1 may recruit BRCA1/BARD1 complex to the aromatase PII promoter for BRCA1/BARD1-mediate transcriptional repression. PMID:21087664

Dr. Ted Trimble: Why I Do Cancer Research

Cancer.gov

In a video, Dr. Ted Trimble talks about the importance of cancer research. World Cancer Research Day commemorates the important role research and cancer researchers play in reducing the global burden of cancer.

Trimble Use Case Information : A Presentation to DOT Adjacent Band Compatibility Workshop #2

DOT National Transportation Integrated Search

2014-12-04

Trimble Use Case Overview: Heavy Civil Construction - Planning, Designing, Building and Operating: Enhanced information, decision making and control across the entire project lifecycle, generating benefits including: - Faster Completion - Reduced Fue...

Transition of NOAA's GPS-Met Data Acquisition and Processing System to the Commercial Sector

NASA Astrophysics Data System (ADS)

Jackson, M. E.; Holub, K.; Callahan, W.; Blatt, S.

2014-12-01

In April of 2014, NOAA/OAR/ESRL Global Systems Division (GSD) and Trimble, in collaboration with Earth Networks, Inc. (ENI) signed a Cooperative Research and Development Agreement (CRADA) to transfer the existing NOAA GPS-Met Data Acquisition and Processing System (GPS-Met DAPS) technology to a commercial Trimble/ENI partnership. NOAA's GPS-Met DAPS is currently operated in a pseudo-operational mode but has proven highly reliable and running at over 95% uptime. The DAPS uses the GAMIT software to ingest dual frequency carrier phase GPS/GNSS observations and ancillary information such as real-time satellite orbits to estimate the zenith-scaled tropospheric (ZTD) signal delays and, where surface MET data are available, retrieve integrated precipitable water vapor (PWV). The NOAA data and products are made available to end users in near real-time. The Trimble/ENI partnership will use the Trimble Pivot™ software with the Atmosphere App to calculate zenith tropospheric (ZTD), tropospheric slant delay, and integrated precipitable water vapor (PWV). Evaluation of the Trimble software is underway starting with a comparison of ZTD and PWV values determined from GPS stations located near NOAA Radiosonde Observation (Upper-Air Observation) launch sites. A success metric was established that requires Trimble's PWV estimates to match ESRL/GSD's to within 1.5 mm 95% of the time, which corresponds to a ZTD uncertainty of less than 10 mm 95% of the time. Initial results indicate that Trimble/ENI data meet and exceed the ZTD metric, but for some stations PWV estimates are out of specification. These discrepancies are primarily due to how offsets between MET and GPS stations are handled and are easily resolved. Additional test networks are proposed that include low terrain/high moisture variability stations, high terrain/low moisture variability stations, as well as high terrain/high moisture variability stations. We will present results from further testing along with a timeline for the transition of the GPS-Met DAPS to an operational commercial service.

What Can College Mean? Lessons from the Bard Prison Initiative

ERIC Educational Resources Information Center

Lagemann, Ellen Condliffe

2011-01-01

The Bard Prison Initiative (BPI), which is a part of the Bard College in Annandale-on-Hudson, New York, is a prison program that operates a full liberal arts program leading to both AA and BA degrees. The students are convicted felons who are serving relatively long sentences for serious, often violent, crimes. They tend to be in their…

Common genetic variation at BARD1 is not associated with Breast cancer risk in BRCA1 or BRCA2 mutation carriers

PubMed Central

Spurdle, Amanda B.; Marquart, Louise; McGuffog, Lesley; Healey, Sue; Sinilnikova, Olga; Wan, Fei; Chen, Xiaoqing; Beesley, Jonathan; Singer, Christian F; Dressler, Anne-Catharine; Gschwantler-Kaulich, Daphne; Blum, Joanne L.; Tung, Nadine; Weitzel, Jeff; Lynch, Henry; Garber, Judy; Easton, Douglas F.; Peock, Susan; Cook, Margaret; Oliver, Clare T.; Frost, Debra; Conroy, Don; Evans, D. Gareth; Lalloo, Fiona; Eeles, Ros; Izatt, Louise; Davidson, Rosemarie; Chu, Carol; Eccles, Diana; Selkirk, Christina G.; Daly, Mary; Isaacs, Claudine; Stoppa-Lyonnet, Dominique; Sinilnikova, Olga M.; Buecher, Bruno; Belotti, Muriel; Mazoyer, Sylvie; Barjhoux, Laure; Verny-Pierre, Carole; Lasset, Christine; Dreyfus, Hélène; Pujol, Pascal; Collonge-Rame, Marie-Agnès; Rookus, Matti A.; Verhoef, Senno; Kriege, Mieke; Hoogerbrugge, Nicoline; Ausems, Margreet G.E.M.; van Os, Theo A.; Wijnen, Juul; Devilee, Peter; Meijers-Heijboer, Hanne E.J.; Blok, Marinus J.; Heikkinen, Tuomas; Nevanlinna, Heli; Jakubowska, Anna; Lubiński, Jan; Huzarski, Tomasz; Byrski, Tomasz; Durocher, Francine; Couch, Fergus J.; Lindor, Noralane M.; Wang, Xianshu; Thomassen, Mads; Domchek, Susan; Nathanson, Kate; Caligo, MA; Jernström, Helena; Liljegren, Annelie; Ehrencrona, Hans; Karlsson, Per; Ganz, Patricia A.; Olopade, Olufunmilayo I.; Tomlinson, Gail; Neuhausen, Susan; Antoniou, Antonis C.; Chenevix-Trench, Georgia; Rebbeck, Timothy R.

2011-01-01

Background Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies. Methods A cohort of 5,546 BRCA1 and 2,865 BRCA2 mutation carriers was used to evaluate risk of breast cancer associated with BARD1 Cys557Ser. In a second non-independent cohort of 1,537 of BRCA1 and 839 BRCA2 mutation carriers, BARD1 haplotypes were also evaluated. Results The BARD1 Cys557Ser variant was not significantly associated with risk of breast cancer from single SNP analysis, with a pooled effect estimate of 0.90 (95%CI: 0.71-1.15) in BRCA1 carriers and 0.87 (95%CI: 0.59-1.29) in BRCA2 carriers. Further analysis of haplotypes at BARD1 also revealed no evidence that additional common genetic variation not captured by Cys557Ser was associated with breast cancer risk. Conclusion Evidence to date does not support a role for BARD1 variation, including the Cy557Ser variant, as a modifier of risk in BRCA1/2 mutation carriers. Impact Interactors of BRCA1/2 have been implicated as modifiers of BRCA1/2-associated cancer risk. Our finding that BARD1 does not contribute to this risk modification may focus research on other genes that do modify BRCA1/2-associated cancer risk. PMID:21393566

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.

PubMed

Wu, Juan; Liu, Xinhui; Fan, Jinjin; Chen, Wenfang; Wang, Juan; Zeng, Youjia; Feng, Xiaorang; Yu, Xueqing; Yang, Xiao

2014-04-06

Bardoxolone methyl (BARD) is an antioxidant modulator that acts through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This study aimed to investigate the role of BARD in protecting kidneys from aristolochic acid (AA)-induced acute kidney injury (AKI). Male C57BL/6 mice received intraperitoneal (i.p.) injections of aristolochic acid I (AAI) (5mg/kg/day) for 5 days to produce acute AA nephropathy (AAN) model. BARD (10mg/kg/day, i.p.) was applied for 7 consecutive days, starting 2 days prior to AAI administration. The mice in the AA group showed AKI as evidenced by worsening kidney function evaluated by blood urea nitrogen (BUN) and serum creatinine (SCr) levels, and severe tubulointerstitial injury marked by massive tubule necrosis in kidney tissues. BARD significantly reduced BUN and SCr levels which were elevated by AAI. Additionally, AAI-induced histopathological renal damage was ameliorated by BARD. Furthermore, the expression of Nrf2 was reduced, and its repressor Kelch-like ECH-associated protein 1 (Keap1) was increased significantly, whereas heme oxygenase-1 (HO-1) was upregulated and NAD(P)H quinone oxidoreductase-1 (NQO1) was barely increased in the cytoplasm of tubules in kidneys after treatment with AAI. BARD significantly upregulated renal Nrf2, NQO1 and HO-1 expression and downregulated Keap1 expression compared with those in the AA group. Moreover, it was found that Nrf2 was expressed both in the cytoplasm and nuclear of glomeruli and tubules, whereas NQO1 and HO-1 were localized in the cytoplasm of tubules only. In conclusion, AA-induced acute renal injury was associated with impaired Nrf2 activation and expression of its downstream target genes in renal tissues. BARD prevented renal damage induced by AAI, and this renoprotective effect may be exerted by activating the Nrf2 signaling pathway and increasing expression of the downstream target genes. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Preschool Guidelines: Rural Model (Trimble Local School District).

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus. Div. of Educational Services.

The purpose of this handbook is to guide rural school districts intending to establish a preschool program. The program described was established in the Trimble Local School District in the rural Appalachian area of northern Athens County, the third poorest district in Ohio. Contents concern: (1) the district's beliefs about children; (2)…

Letters to the Editor

NASA Astrophysics Data System (ADS)

1991-12-01

Radon variations D J Noble Plockton High School, Ross shire IV52 8TU, UK Environmental physics A T Jackson Belfast Institute of Further and Higher Education On mnemonic schemes A T Bardócz Teacher Training College, Szombathely, Hungary Regarding mnemonic devices for Maxwell's relations A H Kalantar Department of Chemistry, University of Alberta, Edmonton, Canada TG6 2G2 On an analogy for Ohm's law H S Fricker Bradford Grammar School Further reflections D Hinson `Brenig', Town Hill, Llanrwst, Gwynedd LL26 0NF, UK Moving charges W Jarvis 6 Peggy''s Mill Road, Edinburgh EH4 6JY, UK More on the distance travelled A Tan Department of Physics, Alabama A&M University, USA

Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis.

PubMed

Huo, Xiang; Hu, Zhibin; Zhai, Xiangjun; Wang, Yan; Wang, Shui; Wang, Xuechen; Qin, Jianwei; Chen, Wenseng; Jin, Guangfu; Liu, Jiyong; Gao, Jun; Wei, Qingyi; Wang, Xinru; Shen, Hongbing

2007-05-01

The BRCA1 Associated RING Domain (BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common (minor allele frequency (MAF)>0.10) non-synonymous polymorphisms (Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes (24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P(int )= 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR=1.81, 95% CI=1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk (adjusted OR=0.74, 95% CI=0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor (PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer.

Preoperative and Postoperative CT Scan Assessment of Pterygomaxillary Junction in Patients Undergoing Le Fort I Osteotomy: Comparison of Pterygomaxillary Dysjunction Technique and Trimble Technique-A Pilot Study.

PubMed

Dadwal, Himani; Shanmugasundaram, S; Krishnakumar Raja, V B

2015-09-01

To determine the rate of complications and occurrence of pterygoid plate fractures comparing two techniques of Le Fort I osteotomy i.e., Classic Pterygomaxillary Dysjunction technique and Trimble technique and to know whether the dimensions of pterygomaxillary junction [determined preoperatively by computed tomography (CT) scan] have any influence on pterygomaxillary separation achieved during surgery. The study group consisted of eight South Indian patients with maxillary excess. A total of 16 sides were examined by CT. Preoperative CT was analyzed for all the patients. The thickness and width of the pterygomaxillary junction and the distance of the greater palatine canal from the pterygomaxillary junction was noted. Pterygomaxillary dysjunction was achieved by two techniques, the classic pterygomaxillary dysjunction technique (Group I) and Trimble technique (Group II). Patients were selected randomly and equally for both the techniques. Dysjunction was analyzed by postoperative CT. The average thickness of the pterygomaxillary junction on 16 sides was 4.5 ± 1.2 mm. Untoward pterygoid plate fractures occurred in Group I in 3 sides out of 8. In Trimble technique (Group II), no pterygoid plate fractures were noted. The average width of the pterygomaxillary junction was 7.8 ± 1.5 mm, distance of the greater palatine canal from pterygomaxillary junction was 7.4 ± 1.6 mm and the length of fusion of pterygomaxillary junction was 8.0 ± 1.9 mm. The Le Fort I osteotomy has become a standard procedure for correcting various dentofacial deformities. In an attempt to make Le Fort I osteotomy safer and avoid the problems associated with sectioning with an osteotome between the maxillary tuberosity and the pterygoid plates, Trimble suggested sectioning across the posterior aspect of the maxillary tuberosity itself. In our study, comparison between the classic pterygomaxillary dysjunction technique and the Trimble technique was made by using postoperative CT scan. It was found that unfavorable pterygoid plate fractures occurred only in dysjunction group and not in Trimble technique group. Preoperative CT scan assessment was done for all the patients to determine the dimension of the pterygomaxillary region. Preoperative CT scan proved to be helpful in not only determining the dimensions of the pterygomaxillary region but we also found out that thickness of the pterygomaxillary junction was an important parameter which may influence the separation at the pterygomaxillary region. No untoward fractures of the pterygoid plates were seen in Trimble technique (Group II) which makes it a safer technique than classic dysjunction technique. It was noted that pterygoid plate fractures occurred in patients in whom the thickness of the pterygomaxillary junction was <3.6 mm (preoperatively). Therefore, preoperative evaluation is important, on the basis of which we can decide upon the technique to be selected for safer and acceptable separation of pterygomaxillary region.

Transition of NOAA's GPS-Met Data Acquisition and Processing System to the Commercial Sector: Inital Results

NASA Astrophysics Data System (ADS)

Jackson, Michael; Blatt, Stephan; Holub, Kirk

2015-04-01

In April of 2014, NOAA/OAR/ESRL Global Systems Division (GSD) and Trimble, in collaboration with Earth Networks, Inc. (ENI) signed a Cooperative Research and Development Agreement (CRADA) to transfer the existing NOAA GPS-Met Data Acquisition and Processing System (GPS-Met DAPS) technology to a commercial Trimble/ENI partnership. NOAA's GPS-Met DAPS is currently operated in a pseudo-operational mode but has proven highly reliable and running at over 95% uptime. The DAPS uses the GAMIT software to ingest dual frequency carrier phase GPS/GNSS observations and ancillary information such as real-time satellite orbits to estimate the zenith-scaled tropospheric (ZTD) signal delays and, where surface MET data are available, retrieve integrated precipitable water vapor (PWV). The NOAA data and products are made available to end users in near real-time. The Trimble/ENI partnership will use the Trimble Pivot™ software with the Atmosphere App to calculate zenith tropospheric (ZTD), tropospheric slant delay, and integrated precipitable water vapor (PWV). Evaluation of the Trimble software is underway starting with a comparison of ZTD and PWV values determined from four sub networks of GPS stations located 1. near NOAA Radiosonde Observation (Upper-Air Observation) launch sites; 2. Stations with low terrain/high moisture variability (Gulf Coast); 3. Stations with high terrain/low moisture variability (Southern California); and 4. Stations with high terrain/high moisture variability (high terrain variability elev. > 1000m). For each network GSD and T/ENI run the same stations for 30 days, compare results, and perform an evaluation of the long-term solution accuracy, precision and reliability. Metrics for success include T/ENI PWV estimates within 1.5 mm of ESRL/GSD's estimates 95% of the time (ZTD uncertainty of less than 10 mm 95% of the time). The threshold for allowable variations in ZTD between NOAA GPS-Met and T/ENI processing are 10mm. The CRADA 1&2 Trimble processing show a variation of 4±2mm and 3±8mm respectively. The threshold for allowable variations in PWV between NOAA GPS-Met and T/ENI processing are 15mm. The CRADA 1&2 Trimble processing show a variation of 2±4mm and 10±13 respectively. The T/ENI PWV and ZTD values meet and exceed the requirements outlined in the CRADA for the first two networks processed. T/ENI Partnership brings a footprint of GNSS and meteorological stations that could significantly enhance the latency, temporal, and geographic density of ZTD and PWV over the US and Europe. We will provide a brief overview of the Trimble Pivot™ software and the Atmosphere App and present results from further testing along with a timeline for the transition of the GPS-Met DAPS to an operational commercial service.

Homer: The Blind Bard

ERIC Educational Resources Information Center

Doorley, Rachelle; King, Judith

2005-01-01

This article describes notable cultural, historical, and artistic elements emanating from sculptures originating in ancient Greece. The "blind bard" and its connection to the legendary Greek poet, Homer; Homer's impact on literary history; trends among Roman sculptures; and Roman replication of Greek art are described. Questions to…

Sediment Management at the Watershed Level

DTIC Science & Technology

2012-08-01

al. 2005). Trimble examined ten river basins (1,000 to 7,500 mi2 ) and found that the sediment yield averaged about six percent. He attributed the...importance of storage and remobilization in controlling sediment yield from the 139 mi2 Coon Creek watershed in Wisconsin. Trimble prepared sediment...Federal government in 1984, DHP activities targeted sixteen watersheds comprising 2,625 mi2 within the Yazoo River Basin in the Lower Mississippi

FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.

PubMed

Liu, Ying; Ao, Xiang; Jia, Zhaojun; Bai, Xiao-Yan; Xu, Zhaowei; Hu, Gaolei; Jiang, Xiao; Chen, Min; Wu, Huijian

2015-03-05

Estrogen receptors (ERs) are critical regulators of breast cancer development. Identification of molecules that regulate the function of ERs may facilitate the development of more effective breast cancer treatment strategies. In this study, we showed that the forkhead transcription factor FOXK2 interacted with ERα, and inhibited ERα-regulated transcriptional activities by enhancing the ubiquitin-mediated degradation of ERα. This process involved the interaction between FOXK2 and BRCA1/BARD1, the E3 ubiquitin ligase of ERα. FOXK2 interacted with BARD1 and acted as a scaffold protein for BRCA1/BARD1 and ERα, leading to enhanced degradation of ERα, which eventually accounted for its decreased transcriptional activity. Consistent with these observations, overexpression of FOXK2 inhibited the transcriptional activity of ERα, decreased the transcription of ERα target genes, and suppressed the proliferation of ERα-positive breast cancer cells. In contract, knockdown of FOXK2 in MCF-7 cells promoted cell proliferation. However, when ERα was also knocked down, knockdown of FOXK2 had no effect on cell proliferation. These findings suggested that FOXK2 might act as a negative regulator of ERα, and its association with both ERα and BRCA1/BARD1 could lead to the down-regulation of ERα transcriptional activity, effectively regulating the function of ERα.

An overview of the challenges in designing, integrating, and delivering BARD: a public chemical biology resource and query portal across multiple organizations, locations, and disciplines

PubMed Central

de Souza, Andrea; Bittker, Joshua; Lahr, David; Brudz, Steve; Chatwin, Simon; Oprea, Tudor I.; Waller, Anna; Yang, Jeremy; Southall, Noel; Guha, Rajarshi; Schurer, Stephan; Vempati, Uma; Southern, Mark R.; Dawson, Eric S.; Clemons, Paul A.; Chung, Thomas D.Y.

2015-01-01

Recent industry-academic partnerships involve collaboration across disciplines, locations, and organizations using publicly funded “open-access” and proprietary commercial data sources. These require effective integration of chemical and biological information from diverse data sources, presenting key informatics, personnel, and organizational challenges. BARD (BioAssay Research Database) was conceived to address these challenges and to serve as a community-wide resource and intuitive web portal for public-sector chemical biology data. Its initial focus is to enable scientists to more effectively use the NIH Roadmap Molecular Libraries Program (MLP) data generated from 3-year pilot and 6-year production phases of the Molecular Libraries Probe Production Centers Network (MLPCN), currently in its final year. BARD evolves the current data standards through structured assay and result annotations that leverage the BioAssay Ontology (BAO) and other industry-standard ontologies, and a core hierarchy of assay definition terms and data standards defined specifically for small-molecule assay data. We have initially focused on migrating the highest-value MLP data into BARD and bringing it up to this new standard. We review the technical and organizational challenges overcome by the inter-disciplinary BARD team, veterans of public and private sector data-integration projects, collaborating to describe (functional specifications), design (technical specifications), and implement this next-generation software solution. PMID:24441647

Bard College Shines

ERIC Educational Resources Information Center

Klier, Gerhard

2012-01-01

With its park-like campus location overlooking the Hudson River and Catskills Mountains in New York's Hudson Valley, it's no wonder that Bard College is committed to being green. At the liberal arts college in Annandale-on-Hudson, students learn and live in 25 geothermal buildings on campus that don't burn fossil fuels on site. Instead of driving…

A Study of the Hadronic Production of $D^0$ and $$\\overline{D}\\,{^0}$$ Mesons: $$x_F$$ and $$p_t$$ Distributions (in Portuguese)

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Mello Neto, Joao Torres

Using a 250 Ge V hadron beam incident on thin targets foils of Be, Al, Cu and W, themore » $$x_F$$ and $$p_t$$ distributions of $D^0$ and $$\\bar{D}^0$$ were measured from Fermilab experiment E769 using the decay mode $$D^0 \\to K^- \\pi^+$$ and c.c. The measurements were made with the $$\\pi^-$$ induced sample, 607 ± 29 events. Fitting the $$x_F$$ distribution to (1- $$x_F)^{\\eta}$$ it was measured $$\\eta$$ = 3.86 ± 0.25 ± 0.10 for $$D0/\\bar{D}^0$$ , $$\\eta$$ = 3.89 ± 0.40 for $D^0$ and $$\\eta$$ = 3.74 ± 0.34 for $$\\bar{D}^0$$ • Fitting the $$p^2_t$$ distribuition to exp $$bp^2_t$$;, it was measured $b$ = 1.05 ± 0.06 ± 0.02 for $$DO/\\bar{D}^0$$ $b$ = 1.12 ± 0.09 for $D^0$ and $b$ = 1.00 ± 0.07 for $$\\bar{D}^0$$. The $$x_F$$ distribution is consistent with the perturbative QCD calculations.« less

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines.

PubMed

de Souza, Andrea; Bittker, Joshua A; Lahr, David L; Brudz, Steve; Chatwin, Simon; Oprea, Tudor I; Waller, Anna; Yang, Jeremy J; Southall, Noel; Guha, Rajarshi; Schürer, Stephan C; Vempati, Uma D; Southern, Mark R; Dawson, Eric S; Clemons, Paul A; Chung, Thomas D Y

2014-06-01

Recent industry-academic partnerships involve collaboration among disciplines, locations, and organizations using publicly funded "open-access" and proprietary commercial data sources. These require the effective integration of chemical and biological information from diverse data sources, which presents key informatics, personnel, and organizational challenges. The BioAssay Research Database (BARD) was conceived to address these challenges and serve as a community-wide resource and intuitive web portal for public-sector chemical-biology data. Its initial focus is to enable scientists to more effectively use the National Institutes of Health Roadmap Molecular Libraries Program (MLP) data generated from the 3-year pilot and 6-year production phases of the Molecular Libraries Probe Production Centers Network (MLPCN), which is currently in its final year. BARD evolves the current data standards through structured assay and result annotations that leverage BioAssay Ontology and other industry-standard ontologies, and a core hierarchy of assay definition terms and data standards defined specifically for small-molecule assay data. We initially focused on migrating the highest-value MLP data into BARD and bringing it up to this new standard. We review the technical and organizational challenges overcome by the interdisciplinary BARD team, veterans of public- and private-sector data-integration projects, who are collaborating to describe (functional specifications), design (technical specifications), and implement this next-generation software solution. © 2014 Society for Laboratory Automation and Screening.

Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.

PubMed

Stewart, Mikaela D; Duncan, Emily D; Coronado, Ernesto; DaRosa, Paul A; Pruneda, Jonathan N; Brzovic, Peter S; Klevit, Rachel E

2017-03-01

The tumor-suppressor protein BRCA1 works with BARD1 to catalyze the transfer of ubiquitin onto protein substrates. The N-terminal regions of BRCA1 and BARD1 that contain their RING domains are responsible for dimerization and ubiquitin ligase activity. This activity is a common feature among hundreds of human RING domain-containing proteins. RING domains bind and activate E2 ubiquitin-conjugating enzymes to promote ubiquitin transfer to substrates. We show that the identity of residues at specific positions in the RING domain can tune activity levels up or down. We report substitutions that create a structurally intact BRCA1/BARD1 heterodimer that is inactive in vitro with all E2 enzymes. Other substitutions in BRCA1 or BARD1 RING domains result in hyperactivity, revealing that both proteins have evolved attenuated activity. Loss of attenuation results in decreased product specificity, providing a rationale for why nature has tuned BRCA1 activity. The ability to tune BRCA1 provides powerful tools for understanding its biological functions and provides a basis to assess mechanisms for rescuing the activity of cancer-associated variations. Beyond the applicability to BRCA1, we show the identity of residues at tuning positions that can be used to predict and modulate the activity of an unrelated RING E3 ligase. These findings provide valuable insights into understanding the mechanism and function of RING E3 ligases like BRCA1. © 2017 The Protein Society.

Explaining the United States-Israel Relationship

DTIC Science & Technology

2013-06-01

OF ACRONYMS AND ABBREVIATIONS AMRAAM Advanced Medium Range Air-to-Air Missiles BARD Binational Agricultural Research and Development BIRD ...United States- Israel Binational Industrial Research and Development ( BIRD ) along with the Binational Agricultural R&D Foundation (BARD) and the...foreign oil. In 2007, the BIRD Energy program was created, which has already received millions in investments for joint United States-Israel

Shakespeare in 3D: Bringing the Bard to Life through New (Old) Media

ERIC Educational Resources Information Center

Kremer, Nick; Sanders, Harlow

2012-01-01

Shakespeare didn't write scripts so much as he wrote plays--live productions to be acted out in front of audiences through multimodal forms of expression. Yet some teachers' script-only approach to the Bard inadvertently isolates students from the many visual, auditory, and performative elements that make his plays so enduring. This article…

Early Risers

ERIC Educational Resources Information Center

Asquith, Chistina

2002-01-01

In this article, the author features Bard High School Early College, the first public school in the country to offer a free, full-time college curriculum--and all the credits that go with it--to high schoolers. In Bard's four-year program, students race through high school requirements in 9th and 10th grades, then take college courses in 11th and…

NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis.

PubMed

Yang, Q; Pan, Q; Li, C; Xu, Y; Wen, C; Sun, F

2016-08-01

NRAGE, a neurotrophin receptor-interacting melanoma antigen-encoding gene homolog, is significantly increased in the nucleus of radioresistant esophageal tumor cell lines and is highly upregulated to promote cell proliferation in esophageal carcinomas (ECs). However, whether the overexpressed NRAGE promotes cell growth by participating in DNA-damage response (DDR) is still unclear. Here we show that NRAGE is required for efficient double-strand breaks (DSBs) repair via homologous recombination repair (HRR) and downregulation of NRAGE greatly sensitizes EC cells to DNA-damaging agents both in vitro and in vivo. Moreover, NRAGE not only regulates the stability of DDR factors, RNF8 and BARD1, in a ubiquitin-proteolytic pathway, but also chaperons the interaction between BARD1 and RNF8 via their RING domains to form a novel ternary complex. Additionally, the expression of NRAGE is closely correlated with RNF8 and BARD1 in esophageal tumor tissues. In summary, our findings reveal a novel function of NRAGE that will help to guide personalized esophageal cancer treatments by targeting NRAGE to increase cell sensitivity to DNA-damaging therapeutics in the long run.

Educating outside the Lines: Bard College at Simon's Rock on a "New Pedagogy" for the Twenty-First Century

ERIC Educational Resources Information Center

Yanoshak, Nancy, Ed.

2011-01-01

Founded in 1966, and premised on the idea that motivated sixteen-year-olds are capable of college work, Bard College at Simon's Rock is an educational "experiment" from the sixties that has endured and prospered. "Educating Outside the Lines" looks at Simon's Rock as a pioneer of the early college movement that has begun to…

"Context-Specific" Teacher Preparation for New York City: An Exploration of the Content of Context in Bard College's Urban Teacher Residency Program

ERIC Educational Resources Information Center

Hammerness, Karen; Craig, Elizabeth

2016-01-01

In this article, we examine a residency program that was developed to prepare teachers specifically for New York City schools--the Bard College Master of Arts in Teaching Urban Teacher Residency program. This focused preparation on the particular urban context of New York City provides us with a unique opportunity to examine the nature of…

Accuracy Investigation of Creating Orthophotomaps Based on Images Obtained by Applying Trimble-UX5 UAV

NASA Astrophysics Data System (ADS)

Hlotov, Volodymyr; Hunina, Alla; Siejka, Zbigniew

2017-06-01

The main purpose of this work is to confirm the possibility of making largescale orthophotomaps applying unmanned aerial vehicle (UAV) Trimble- UX5. A planned altitude reference of the studying territory was carried out before to the aerial surveying. The studying territory has been marked with distinctive checkpoints in the form of triangles (0.5 × 0.5 × 0.2 m). The checkpoints used to precise the accuracy of orthophotomap have been marked with similar triangles. To determine marked reference point coordinates and check-points method of GNSS in real-time kinematics (RTK) measuring has been applied. Projecting of aerial surveying has been done with the help of installed Trimble Access Aerial Imaging, having been used to run out the UX5. Aerial survey out of the Trimble UX5 UAV has been done with the help of the digital camera SONY NEX-5R from 200m and 300 m altitude. These aerial surveying data have been calculated applying special photogrammetric software Pix 4D. The orthophotomap of the surveying objects has been made with its help. To determine the precise accuracy of the got results of aerial surveying the checkpoint coordinates according to the orthophotomap have been set. The average square error has been calculated according to the set coordinates applying GNSS measurements. A-priori accuracy estimation of spatial coordinates of the studying territory using the aerial surveying data have been calculated: mx=0.11 m, my=0.15 m, mz=0.23 m in the village of Remeniv and mx=0.26 m, my=0.38 m, mz=0.43 m in the town of Vynnyky. The accuracy of determining checkpoint coordinates has been investigated using images obtained out of UAV and the average square error of the reference points. Based on comparative analysis of the got results of the accuracy estimation of the made orthophotomap it can be concluded that the value the average square error does not exceed a-priori accuracy estimation. The possibility of applying Trimble UX5 UAV for making large-scale orthophotomaps has been investigated. The aerial surveying output data using UAV can be applied for monitoring potentially dangerous for people objects, the state border controlling, checking out the plots of settlements. Thus, it is important to control the accuracy the got results. Having based on the done analysis and experimental researches it can be concluded that applying UAV gives the possibility to find data more efficiently in comparison with the land surveying methods. As the result, the Trimble UX5 UAV gives the possibility to survey built-up territories with the required accuracy for making orthophotomaps with the following scales 1: 2000, 1: 1000, 1: 500.

Tumor Suppression by BRCA-1: A Critical Role at DNA Replication Forks

DTIC Science & Technology

2006-10-01

replication defect. We wished to test the hypothesis that BRCA1/BARD1 function during DNA replication supporting DNA transactions at replication forks. We...are using cell-free extracts derived from Xenopus laevis eggs that support: 1. Semi-conservative, cell-cycle regulated DNA replication ; 2. Many facets...complex assembles to chromatin in a DNA replication -dependent manner. Finally, we show that BRCA1/BARD1 loading to chromatin does not dramatically

Deciphering the Molecular Mechanisms of Breast Cancer

DTIC Science & Technology

2005-03-01

2007). Nicolas E., Lee M.G., Hakimi M.A., Cam H.P., Grewal S.I., Shiekhattar R. Fussion yeast homologs of human H3 lysinee 4 demethylase regulate a...Baillat D., Hakimi M.A., Naar A., Shilatifard A., Cooch N., Shiekhattar R. Integrator, a multiprotein mediator of small nuclear RNA processing...fractionof FLAG-BARD1 using anti-FLAG antibodies from H1299 of BRCA1 and BARD1 elute at a smaller molecular masscells. Nuclear extract from native H1299

DNA Double-Strand Break Repair Genes and Oxidative Damage in Brain Metastasis of Breast Cancer

PubMed Central

Evans, Lynda; Duchnowska, Renata; Reed, L. Tiffany; Palmieri, Diane; Qian, Yongzhen; Badve, Sunil; Sledge, George; Gril, Brunilde; Aladjem, Mirit I.; Fu, Haiqing; Flores, Natasha M.; Gökmen-Polar, Yesim; Biernat, Wojciech; Szutowicz-Zielińska, Ewa; Mandat, Tomasz; Trojanowski, Tomasz; Och, Waldemar; Czartoryska-Arlukowicz, Bogumiła; Jassem, Jacek; Mitchell, James B.

2014-01-01

Background Breast cancer frequently metastasizes to the brain, colonizing a neuro-inflammatory microenvironment. The molecular pathways facilitating this colonization remain poorly understood. Methods Expression profiling of 23 matched sets of human resected brain metastases and primary breast tumors by two-sided paired t test was performed to identify brain metastasis–specific genes. The implicated DNA repair genes BARD1 and RAD51 were modulated in human (MDA-MB-231-BR) and murine (4T1-BR) brain-tropic breast cancer cell lines by lentiviral transduction of cDNA or short hairpin RNA (shRNA) coding sequences. Their functional contribution to brain metastasis development was evaluated in mouse xenograft models (n = 10 mice per group). Results Human brain metastases overexpressed BARD1 and RAD51 compared with either matched primary tumors (1.74-fold, P < .001; 1.46-fold, P < .001, respectively) or unlinked systemic metastases (1.49-fold, P = .01; 1.44-fold, P = .008, respectively). Overexpression of either gene in MDA-MB-231-BR cells increased brain metastases by threefold to fourfold after intracardiac injections, but not lung metastases upon tail-vein injections. In 4T1-BR cells, shRNA-mediated RAD51 knockdown reduced brain metastases by 2.5-fold without affecting lung metastasis development. In vitro, BARD1- and RAD51-overexpressing cells showed reduced genomic instability but only exhibited growth and colonization phenotypes upon DNA damage induction. Reactive oxygen species were present in tumor cells and elevated in the metastatic neuro-inflammatory microenvironment and could provide an endogenous source of genotoxic stress. Tempol, a brain-permeable oxygen radical scavenger suppressed brain metastasis promotion induced by BARD1 and RAD51 overexpression. Conclusions BARD1 and RAD51 are frequently overexpressed in brain metastases from breast cancer and may constitute a mechanism to overcome reactive oxygen species–mediated genotoxic stress in the metastatic brain. PMID:24948741

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

PubMed

Woditschka, Stephan; Evans, Lynda; Duchnowska, Renata; Reed, L Tiffany; Palmieri, Diane; Qian, Yongzhen; Badve, Sunil; Sledge, George; Gril, Brunilde; Aladjem, Mirit I; Fu, Haiqing; Flores, Natasha M; Gökmen-Polar, Yesim; Biernat, Wojciech; Szutowicz-Zielińska, Ewa; Mandat, Tomasz; Trojanowski, Tomasz; Och, Waldemar; Czartoryska-Arlukowicz, Bogumiła; Jassem, Jacek; Mitchell, James B; Steeg, Patricia S

2014-07-01

Breast cancer frequently metastasizes to the brain, colonizing a neuro-inflammatory microenvironment. The molecular pathways facilitating this colonization remain poorly understood. Expression profiling of 23 matched sets of human resected brain metastases and primary breast tumors by two-sided paired t test was performed to identify brain metastasis-specific genes. The implicated DNA repair genes BARD1 and RAD51 were modulated in human (MDA-MB-231-BR) and murine (4T1-BR) brain-tropic breast cancer cell lines by lentiviral transduction of cDNA or short hairpin RNA (shRNA) coding sequences. Their functional contribution to brain metastasis development was evaluated in mouse xenograft models (n = 10 mice per group). Human brain metastases overexpressed BARD1 and RAD51 compared with either matched primary tumors (1.74-fold, P < .001; 1.46-fold, P < .001, respectively) or unlinked systemic metastases (1.49-fold, P = .01; 1.44-fold, P = .008, respectively). Overexpression of either gene in MDA-MB-231-BR cells increased brain metastases by threefold to fourfold after intracardiac injections, but not lung metastases upon tail-vein injections. In 4T1-BR cells, shRNA-mediated RAD51 knockdown reduced brain metastases by 2.5-fold without affecting lung metastasis development. In vitro, BARD1- and RAD51-overexpressing cells showed reduced genomic instability but only exhibited growth and colonization phenotypes upon DNA damage induction. Reactive oxygen species were present in tumor cells and elevated in the metastatic neuro-inflammatory microenvironment and could provide an endogenous source of genotoxic stress. Tempol, a brain-permeable oxygen radical scavenger suppressed brain metastasis promotion induced by BARD1 and RAD51 overexpression. BARD1 and RAD51 are frequently overexpressed in brain metastases from breast cancer and may constitute a mechanism to overcome reactive oxygen species-mediated genotoxic stress in the metastatic brain. Published by Oxford University Press 2014.

First Experiences with the Trimble SX10 Scanning Total Station for Building Facade Survey

NASA Astrophysics Data System (ADS)

Lachat, E.; Landes, T.; Grussenmeyer, P.

2017-02-01

The use of Terrestrial Laser Scanner (TLS) tends to become a solution in many research areas related to large scale surveying. Meanwhile, the technological advances combined with the investigation of user needs have brought to the design of innovative devices known as scanning total stations. Such instruments merge in a unique hardware both scanning and surveying facilities. Even if their scanning rate is often reduced compared to conventional TLS, they make it possible to directly georeference laser scanning projects and to complete them with measurements of individual points of interest. The recent Trimble SX10 which was launched on the market in early October 2016 has been tested and some experiences carried out with it are reported in this paper. The analyses mainly focus on the survey of a building facade. Next to laser scanning survey, a photogrammetry campaign using an Unmanned Aerial Vehicle (UAV) has been carried out. These different datasets are used to assess the Trimble SX10 issued point clouds through a set of comparisons. Since georeferencing is possible either directly or indirectly using this device, data processed both ways are also compared to conclude about the more reliable method.

The Heterogeneous Photocatalytic Decomposition of Benzoic Acid and Adipic Acid on Platinized TiO2 Powder. The Photo-Kolbe Decarboxylative Route to the Breakdown of the Benzene Ring and to the Production to Butane.

DTIC Science & Technology

1980-10-29

adsorbed oxygen on powders. 23. Jaeger, C.D.; Bard, A.J. J. Ph s. Chem. 1979, 83, 3746. 24. Izumi, I; Dunn, W. W.; Wilbourn , K. 0.; Fan, F-R. F.; Bard, A... Joseph Singer, Code 302-1 Electrochimica Corporation NASA-Lewis Attention: Technical Library 21000 BrookDark Road 2485 Charleston Poad Cleveland, Ohio

[First debates regarding the legalization of drug use in Argentina at the start of the 20th century: the proposal of Dr. Leopoldo Bard and its sociohistorical context].

PubMed

Sánchez Antelo, Victoria

2012-12-01

This paper analyzes the discourses of Argentine doctor and public health professional Leopoldo Bard using three texts on drug abuse published between 1923 and 1933. These texts embody the debates of the time regarding the role of the State, public policies at the national and regional level and, particularly, the US influence in Argentina exerted through the figure of Dr. Bard. The legislative measures and policies of that time, undoubtedly of a repressive character, were key in the State's advances into the private sphere and in the increasing importance of professional organizations in the definition of the material and symbolic borders of the socially acceptable, including those related to drug use. The multiple purposes these policies seem to satisfy are also highlighted: at the local level they enable other forms of repressing conflicts arising from immigration, while at the international level they appease US requirements.

Physical Properties of Venous Stents: An Experimental Comparison.

PubMed

Dabir, Darius; Feisst, Andreas; Thomas, Daniel; Luetkens, Julian A; Meyer, Carsten; Kardulovic, Ana; Menne, Matthias; Steinseifer, Ulrich; Schild, Hans H; Kuetting, Daniel L R

2018-06-01

Iliocaval obstruction is a substantial contributor to chronic venous insufficiency and is increasingly being treated endovascularly with angioplasty and stent placement. Utilization of an appropriate stent for treatment is pivotal; however, until today, mechanical properties of venous stents remain unknown. We analyzed the radial resistive force, the chronic outward force, as well as the crush resistance of seven stent models [Zilver Vena (Cook, Bjaeverskov, Denmark), Sinus Venous, Sinus Obliquus and Sinus XL Flex (Optimed, Ettlingen, Germany), Vici (Veniti; St. Louis, USA), Wallstent (Boston Scientific, Marlborough, USA), and Venovo (Bard, Tempe, USA)] in vitro using a radial force testing machine (RX-650, Machine Solutions Inc., Flagstaff, AZ, USA) and a hardness testing machine (zwickiLine, Zwick Roell, Ulm, Germany). The Sinus Obliquus revealed the highest radial resistive force (19.41 N/cm) and the highest chronic outward force at 50 and 30% nominal diameter (7.93 N/cm at 50%, 16.97 N/cm at 30%) while the Venovo revealed the highest chronic outward force at 90 and 80% nominal diameter (4.83 N/cm at 90%, 5.37 N/cm at 80%). The radial resistive force and the chronic outward force of the Wallstent greatly depended on whether the stent ends were fixated. The Wallstent revealed the highest crush resistance at nominal diameters of 90% (0.46 N/cm) to 60% (1.16 N/cm). The Sinus Obliquus revealed the highest crush resistance at a nominal diameter of 50% (1.41 N/cm). Venous stents greatly differ regarding their mechanical properties. These results should be considered when choosing an appropriate stent for the treatment of venous obstruction.

Habitat Evaluation Procedures (HEP) Report; Tacoma/Trimble Area Management Plan, Technical Report 2001-2003.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Entz, Ray; Lockwood, Jr., Neil; Holmes, Darren

2003-10-01

In 2000 and 2001, the Kalispel Natural Resource Department (KNRD) continued to mitigate the wildlife habitat losses as part of the Albeni Falls Wildlife Mitigation Project. Utilizing Bonneville Power Administration (BPA) funds, the Kalispel Tribe of Indians (Tribe) purchased three projects totaling nearly 1,200 acres. The Tacoma/Trimble Wildlife Management Area is a conglomeration of properties now estimated at 1,700 acres. It is the Tribe's intent to manage these properties in cooperation and collaboration with the Pend Oreille County Public Utility District (PUD) No. 1 and the U.S. Fish and Wildlife Service (USFWS) to benefit wildlife habitats and associated species, populations,more » and guilds.« less

The Heterogeneous Photocatalytic Oxidation of Hydrocarbons on Platinized TiO2 Powders.

DTIC Science & Technology

1980-08-28

V W DUNN, K 0 WILBOURN NOO1-78-C-OS92 UCLASSIFIE D T - 10 ML I.’ fflfllfl~fflfllflfEEEEEEEEEl IIIII 1.1 . ILL 111L25 .4~I~ ( .6III MICROCOPY...Photocatalytic Oxidation of Hydrocarbons on Platinized TiO 2 Powders O by Ikuichiro Izumi, Wendell W. Dunn, Keith 0. Wilbourn , Fu-Ren F. Fan, and Allen J. Bard...Hydrocarbons on Platinized TiO 2 Powders. Ikuichiro Izumi, Wendell W. Dunn, Keith 0. Wilbourn , Fu-Ren F. Fan, and Allen J. Bard* Department of Chemistry, The

Applications of Scanning Tunneling Microscopy to Electrochemistry

DTIC Science & Technology

1988-10-28

electrochemically pretreated platinum surfaces in air by baro and coworkers (68) and by Fan and bard (Fan, F-R.F.; Bard, A.J. Anl ._Chem,, submitted) have...W.V.; Coleman, R.V.; Drake, B.; Hansma, P.K. MXL. Rev, A 1986 4, 994-1005. 10. Smith, D.P.E.; Kirk, M.D.; Quate, C.F. - 1987, 8, 6034 -38. 11...Electroanal. Chem. 1988, 238, 9-31. 65. Wightman, R.M. Anl hm 1981, U3, lI26A-31A. 66. Gong. L.; Reed, R.A.; Longuire, N.; Murray, R.W. J. Phxs. Chem

Investigation of a Combined Surveying and Scanning Device: The Trimble SX10 Scanning Total Station

PubMed Central

Lachat, Elise; Landes, Tania; Grussenmeyer, Pierre

2017-01-01

Surveying fields from geosciences to infrastructure monitoring make use of a wide range of instruments for accurate 3D geometry acquisition. In many cases, the Terrestrial Laser Scanner (TLS) tends to become an optimal alternative to total station measurements thanks to the high point acquisition rate it offers, but also to ever deeper data processing software functionalities. Nevertheless, traditional surveying techniques are valuable in some kinds of projects. Nowadays, a few modern total stations combine their conventional capabilities with those of a laser scanner in a unique device. The recent Trimble SX10 scanning total station is a survey instrument merging high-speed 3D scanning and the capabilities of an image-assisted total station. In this paper this new instrument is introduced and first compared to state-of-the-art image-assisted total stations. The paper also addresses the topic of various laser scanning projects and the delivered point clouds are compared with those of other TLS. Directly and indirectly georeferenced projects have been carried out and are investigated in this paper, and a polygonal traverse is performed through a building. Comparisons with the results delivered by well-established survey instruments show the reliability of the Trimble SX10 for geodetic work as well as for scanning projects. PMID:28362319

Verification of the Usefulness of the Trimble Rtx Extended Satellite Technology with the Xfill Function in the Local Network Implementing Rtk Measurements

NASA Astrophysics Data System (ADS)

Siejka, Zbigniew

2014-12-01

The paper presents the method of satellite measurements, which gives users the ability of GNSS continuous precise positioning in real time, even in the case of short interruptions in receiving the correction of the local ground system of measurements support. The proposed method is a combination of two satellite positioning technologies RTN GNSS and RTX Extended. In technology RTX Extended the xFill function was used for precise positioning in real time and in the local reference system. This function provides the ability to perform measurement without the need for constant communication with the ground support satellite system. Test measurements were performed on a test basis located in Krakow, and RTN GNSS positioning was done based on the national network of reference stations of the ASGEUPOS. The solution allows for short (up to 5 minutes) interruptions in radio or internet communication. When the primary stream of RTN correction is not available, then the global corrections Trimble xFill broadcasted by satellite are used. The new technology uses in the real-time data from the global network of tracking stations and contributes significantly to improving the quality and efficiency of surveying works. At present according to the authors, technology Trimble CenterPoint RTX can guarantee repeatability of measurements not worse than 3.8 cm (Trimble Survey Division, 2012). In the paper the comparative analysis of measurement results between the two technologies was performed: RTN carried out in the classic way, which was based on the corrections of the terrestrial local network of the Polish system of active geodetic network (ASG-EUPOS) and RTK xFill technology. The results were related to the data of test network, established as error free. The research gave satisfactory results and confirmed the great potential of the use of the new technology in the geodetic work realization. By combining these two technologies of GNSS surveying the user can greatly improve the overall performance of real-time positioning.

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

PubMed Central

Copple, Ian M.; Shelton, Luke M.; Walsh, Joanne; Kratschmar, Denise V.; Lister, Adam; Odermatt, Alex; Goldring, Christopher E.; Dinkova-Kostova, Albena T.; Honda, Tadashi; Park, B. Kevin

2014-01-01

The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted due to adverse cardiovascular events in chronic kidney disease patients, although the underlying mechanisms are yet to be resolved. The majority of small molecule Nrf2 inducers are electrophilic and trigger Nrf2 accumulation via the chemical modification of its redox-sensitive repressor Keap1. Therefore, it is pertinent to question whether the therapeutic targeting of Nrf2 could be hindered in many cases by the inherent reactivity of a small molecule inducer toward unintended cellular targets, a key mechanism of drug toxicity. Using H4IIE-ARE8L hepatoma cells, we have examined the relationship between (a) Nrf2 induction potency, (b) toxicity and (c) in vitro therapeutic index (ratio of b:a) for BARD and a number of other small molecule activators of Nrf2. We show that BARD exhibits the highest potency toward Nrf2 and the largest in vitro therapeutic index among compounds that have been investigated clinically (namely BARD, sulforaphane and dimethylfumarate). Through further examination of structurally related TPs, we demonstrate that an increase in potency toward Nrf2 is associated with a relatively smaller increase in toxicity, indicating that medicinal chemistry can be used to enhance the specificity of a compound as an inducer of Nrf2 signaling whilst simultaneously increasing its therapeutic index. These findings will inform the continuing design and development of drugs targeting Nrf2. PMID:24798383

Administration of CREON® pancrelipase pellets via gastrostomy tube is feasible with no loss of gastric resistance or lipase activity: an in vitro study.

PubMed

Shlieout, George; Koerner, Andreas; Maffert, Mario; Forssmann, Kristin; Caras, Steven

2011-01-01

In clinical practice, the need sometimes arises to administer pancreatic enzyme replacement therapy via gastrostomy tube (G-tube) by mixing the pellets contained in the capsules with soft food. The objective of this study was to identify G-tubes that allow administration of pancrelipase gastro-resistant pellets without clogging, sticking, pellet damage or loss of enteric coating integrity. In this in vitro study, CREON® (pancrelipase) Delayed-Release Capsules were opened and the pellets sprinkled onto a small amount of baby food of pH <4.5 (applesauce and bananas manufactured by both Gerber and Beech-Nut). The mixture was stirred gently and after 15 minutes poured into a 35 mL syringe and pushed slowly (~15 mL in 10-15 seconds) through a G-tube. Pellets were collected and the tube flushed with water. G-tubes were inspected visually for clogging/sticking and damage to pellets was assessed. If there was none with all four foods, pellet integrity (gastric resistance and lipase activity) was assessed by an in vitro dissolution method with a 2-hour gastric simulation step. The activity required to confirm integrity was ≥80% of actual US Pharmacopeia lipase activity per capsule. G-tubes initially tested were Kimberly-Clark MIC Bolus® size 14 French (Fr) and upwards and Kimberly-Clark MIC-KEY® 14 Fr and upwards. Following successful testing, assessment of Bard® Tri-Funnel 18 Fr and Bard® Button 18 Fr G-tubes was carried out. Based on the absence of clogging, sticking and visible damage to pellets, and the maintenance of pellet integrity, administration of CREON® pancrelipase pellets was feasible through the following G-tubes: Kimberly-Clark MIC Bolus® size 18 Fr, Kimberly-Clark MIC-KEY® 16 Fr, Bard® Tri-Funnel 18 Fr and Bard® Button 18 Fr. Lipase activity met the predetermined specification and was ≥90% for all four tubes and all four foods, with no differences versus untreated pellets (i.e. pellets not mixed with baby food or pushed through a G-tube). These data apply to all CREON® pancrelipase capsule formulations, regardless of their strength in lipase units, as pellet composition, size and quality are identical. CREON® pancrelipase pellets can be mixed with baby food of pH <4.5 and administered via the following G-tubes without clogging, sticking or visible pellet damage, and with no loss of gastric resistance or lipase activity: Kimberly-Clark MIC Bolus® size 18 Fr and larger, Kimberly-Clark MIC-KEY® 16 Fr and larger, Bard® Tri-Funnel 18 Fr and larger and Bard® Button 18 Fr and larger.

Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS): A rapid test for enteric coating thickness and integrity of controlled release pellet formulations.

PubMed

Alfarsi, Anas; Dillon, Amy; McSweeney, Seán; Krüse, Jacob; Griffin, Brendan; Devine, Ken; Sherry, Patricia; Henken, Stephan; Fitzpatrick, Stephen; Fitzpatrick, Dara

2018-06-10

There are no rapid dissolution based tests for determining coating thickness, integrity and drug concentration in controlled release pellets either during production or post-production. The manufacture of pellets requires several coating steps depending on the formulation. The sub-coating and enteric coating steps typically take up to six hours each followed by additional drying steps. Post production regulatory dissolution testing also takes up to six hours to determine if the batch can be released for commercial sale. The thickness of the enteric coating is a key factor that determines the release rate of the drug in the gastro-intestinal tract. Also, the amount of drug per unit mass decreases with increasing thickness of the enteric coating. In this study, the coating process is tracked from start to finish on an hourly basis by taking samples of pellets during production and testing those using BARDS (Broadband Acoustic Resonance Dissolution Spectroscopy). BARDS offers a rapid approach to characterising enteric coatings with measurements based on reproducible changes in the compressibility of a solvent due to the evolution of air during dissolution. This is monitored acoustically via associated changes in the frequency of induced acoustic resonances. A steady state acoustic lag time is associated with the disintegration of the enteric coatings in basic solution. This lag time is pH dependent and is indicative of the rate at which the coating layer dissolves. BARDS represents a possible future surrogate test for conventional USP dissolution testing as its data correlates directly with the thickness of the enteric coating, its integrity and also with the drug loading as validated by HPLC. Copyright © 2018 Elsevier B.V. All rights reserved.

The decay width of the Z_c(3900) as an axialvector tetraquark state in solid quark-hadron duality

NASA Astrophysics Data System (ADS)

Wang, Zhi-Gang; Zhang, Jun-Xia

2018-01-01

In this article, we tentatively assign the Z_c^± (3900) to be the diquark-antidiquark type axialvector tetraquark state, study the hadronic coupling constants G_{Z_cJ/ψ π }, G_{Z_cη _cρ }, G_{Z_cD \\bar{D}^{*}} with the QCD sum rules in details. We take into account both the connected and disconnected Feynman diagrams in carrying out the operator product expansion, as the connected Feynman diagrams alone cannot do the work. Special attentions are paid to matching the hadron side of the correlation functions with the QCD side of the correlation functions to obtain solid duality, the routine can be applied to study other hadronic couplings directly. We study the two-body strong decays Z_c^+(3900)→ J/ψ π ^+, η _cρ ^+, D^+ \\bar{D}^{*0}, \\bar{D}^0 D^{*+} and obtain the total width of the Z_c^± (3900). The numerical results support assigning the Z_c^± (3900) to be the diquark-antidiquark type axialvector tetraquark state, and assigning the Z_c^± (3885) to be the meson-meson type axialvector molecular state.

Pigtail catheters used for percutaneous fluid drainage: comparison of performance characteristics.

PubMed

Macha, Douglas B; Thomas, John; Nelson, Rendon C

2006-03-01

To compare the performance characteristics of various single-lumen all-purpose pigtail drainage catheters. The following parameters were compared: flow rates between catheters of the same size, whether changing the fluid viscosity has any effect on catheter comparisons, the effect on flow of leaving an open three-way stopcock in the drainage pathway, the tendency of the catheters to kink, and catheter patency after kinking, as measured according to flow. All-purpose 8.0-, 8.3-, and 8.5-F (collectively referred to as 8-F); 10.0-, 10.2-, and 10.3-F (collectively referred to as 10-F); and 12.0-F pigtail drainage catheters from three manufacturers were evaluated. Data were compared by using two-tailed t tests after normal distributions were confirmed. P < .05 was considered to represent a significant difference. At comparison of the 8-F catheters, the C.R. Bard catheters demonstrated better flow rates than the Cook and Boston Scientific devices. Among the 10-F catheters, there were no significant differences in the flow rates of fluid with viscosity equivalent to that of water between the C.R. Bard and Boston Scientific catheters; however, both these catheter types demonstrated significantly (P < .05) better flow rates than the Cook devices. Among the 12-F catheters, the C.R. Bard catheters demonstrated significantly (P < .05) better flow rates than the other two catheter types. Changing the fluid viscosity caused no changes in comparison results. In all catheter groups, the presence of a stopcock significantly (P < .05) impaired flow. None of the evaluated catheters demonstrated a clear advantage in terms of patency or susceptibility to kinking. At comparison of the in vitro performances of catheters from different manufacturers, the C.R. Bard 8.0-F and Cook 10.2-F catheters had comparable flow rates, and flow rates through the C.R. Bard and Boston Scientific 10.0-F catheters were comparable to flow rates through the Cook and Boston Scientific 12.0-F catheters. Varying viscosity had no effect on comparisons of catheter flow rates; however, a stopcock between the vacuum source and the catheter was noted to impair flow rates in all brands and sizes of evaluated catheters. Copyright RSNA, 2006.

Geologic map of the greater Denver area, Front Range urban corridor, Colorado

USGS Publications Warehouse

Trimble, Donald E.; Machette, Michael N.

1979-01-01

This digital map shows the areal extent of surficial deposits and rock stratigraphic units (formations) as compiled by Trimble and Machette from 1973 to 1977 and published in 1979 under the Front Range Urban Corridor Geology Program. Trimble and Machette compiled their geologic map from published geologic maps and unpublished geologic mapping having varied map unit schemes. A convenient feature of the compiled map is its uniform classification of geologic units that mostly matches those of companion maps to the north (USGS I-855-G) and to the south (USGS I-857-F). Published as a color paper map, the Trimble and Machette map was intended for land-use planning in the Front Range Urban Corridor. This map recently (1997-1999) was digitized under the USGS Front Range Infrastructure Resources Project. In general, the mountainous areas in the western part of the map exhibit various igneous and metamorphic bedrock units of Precambrian age, major faults, and fault brecciation zones at the east margin (5-20 km wide) of the Front Range. The eastern and central parts of the map (Colorado Piedmont) depict a mantle of unconsolidated deposits of Quaternary age and interspersed outcroppings of Cretaceous or Tertiary-Cretaceous sedimentary bedrock. The Quaternary mantle comprises eolian deposits (quartz sand and silt), alluvium (gravel, sand, and silt of variable composition), colluvium, and a few landslides. At the mountain front, north-trending, dipping Paleozoic and Mesozoic sandstone, shale, and limestone bedrock formations form hogbacks and intervening valleys.

Measurement of D 0– $$\\bar{D}$$ 0 mixing and search for CP violation in D 0 →K +K -, π +π ₋ decays with the full Belle data set

DOE PAGES

Staric, M.; Abdesselam, A.; Adachi, I.; ...

2015-12-14

Here, we report an improved measurement of D 0–more » $$\\bar{D}$$ 0 mixing and a search for CP violation in D 0 decays to CP -even final states K +K – and π +π –. The measurement is based on the final Belle data sample of 976 fb –1. The results are y CP = (1.11 ± 0.22 ± 0.09)% and A Γ = (–0.03 ± 0.20 ± 0.07)%, where the first uncertainty is statistical and the second is systematic.« less

Measurement of D 0– $$\\bar{D}$$ 0 mixing and search for CP violation in D 0 →K +K -, π +π ₋ decays with the full Belle data set

DOE Office of Scientific and Technical Information (OSTI.GOV)

Staric, M.; Abdesselam, A.; Adachi, I.

Here, we report an improved measurement of D 0–more » $$\\bar{D}$$ 0 mixing and a search for CP violation in D 0 decays to CP -even final states K +K – and π +π –. The measurement is based on the final Belle data sample of 976 fb –1. The results are y CP = (1.11 ± 0.22 ± 0.09)% and A Γ = (–0.03 ± 0.20 ± 0.07)%, where the first uncertainty is statistical and the second is systematic.« less

Lipid and liver abnormalities in haemoglobin A1c-defined prediabetes and type 2 diabetes.

PubMed

Calanna, S; Scicali, R; Di Pino, A; Knop, F K; Piro, S; Rabuazzo, A M; Purrello, F

2014-06-01

We aimed to investigate lipid abnormalities and liver steatosis in patients with HbA1c-defined prediabetes and type 2 diabetes compared to individuals with HbA1c-defined normoglycaemia. Ninety-one subjects with prediabetes according to HbA1c, i.e. from 5.7 to 6.4% (39-46 mmol/mol), 50 newly diagnosed patients with HbA1c-defined type 2 diabetes (HbA1c ≥6.5% [≥48 mmol/mol]), and 67 controls with HbA1c lower than 5.7% (<39 mmol/mol), were studied. Fasting blood samples for lipid profiles, fatty liver index (FLI), bioimpedance analysis, ultrasound scan of the liver, and BARD (body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes) score for evaluation of liver fibrosis, were performed in all subjects. In comparison to controls, subjects with prediabetes were characterised by: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure, triglycerides levels and apolipoprotein B/apolipoprotein AI ratio, higher FLI, increased prevalence of and more severe hepatic steatosis, similar BARD score, and higher total body fat mass. In comparison to subjects with diabetes, subjects with prediabetes exhibited: similar blood pressure and apolipoprotein B/apolipoprotein AI ratio, similar FLI, reduced prevalence of and less severe hepatic steatosis, lower BARD score, increased percent fat and lower total body muscle mass. In comparison to controls, subjects with diabetes showed: lower apolipoprotein AI and HDL cholesterol levels, higher blood pressure and triglycerides levels, higher FLI, increased prevalence of and more severe hepatic steatosis, higher BARD score, and higher total body muscle mass. Moreover, HbA1c was correlated with BMI, HOMA-IR, triglycerides, HDL cholesterol, AST, and ALT. Subjects with HbA1c-defined prediabetes and type 2 diabetes, respectively, are characterised by abnormalities in lipid profile and liver steatosis, thus exhibiting a severe risk profile for cardiovascular and liver diseases. Copyright © 2014 Elsevier B.V. All rights reserved.

A spatial database of bedding attitudes to accompany Geologic map of the greater Denver area, Front Range Urban Corridor, Colorado

USGS Publications Warehouse

Trimble, Donald E.; Machette, Michael N.; Brandt, Theodore R.; Moore, David W.; Murray, Kyle E.

2003-01-01

This digital map shows bedding attitude symbols display over the geographic extent of surficial deposits and rock stratigraphic units (formations) as compiled by Trimble and Machette 1973-1977 and published in 1979 (U.S. Geological Survey Map I-856-H) under the Front Range Urban Corridor Geology Program. Trimble and Machette compiled their geologic map from published geologic maps and unpublished geologic mapping having varied map unit schemes. A convenient feature of the compiled map is its uniform classification of geologic units that mostly matches those of companion maps to the north (USGS I-855-G) and to the south (USGS I-857-F). Published as a color paper map, the Trimble and Machette map was intended for land-use planning in the Front Range Urban Corridor. This map recently (1997-1999), was digitized under the USGS Front Range Infrastructure Resources Project (see cross-reference). In general, the mountainous areas in the west part of the map exhibit various igneous and metamorphic bedrock units of Precambrian age, major faults, and fault brecciation zones at the east margin (5-20 km wide) of the Front Range. The eastern and central parts of the map (Colorado Piedmont) depict a mantle of unconsolidated deposits of Quaternary age and interspersed outcroppings of Cretaceous or Tertiary-Cretaceous sedimentary bedrock. The Quaternary mantle is comprised of eolian deposits (quartz sand and silt), alluvium (gravel, sand, and silt of variable composition), colluvium, and few landslides. At the mountain front, north-trending, dipping Paleozoic and Mesozoic sandstone, shale, and limestone bedrock formations form hogbacks and intervening valleys.

Covered stent graft for treatment of a pseudoaneurysm and carotid blowout syndrome

PubMed Central

Janjua, Nazli; Alkawi, Ammar; Georgiadis, Alexandros L.; Kirmani, Jawad F.; Qureshi, Adnan I.

2008-01-01

Background Carotid blowout syndrome with pseudoaneurysm, a rapidly progressive pathology, may present emergently with massive oral hemorrhage. Use of an endograft prosthesis offers a treatment strategy with salvation of the carotid artery. Case History: A 55 year old man with advanced squamous cell carcinoma of the head and neck presented with recurrent transoral hemorrhage, requiring endovascular treatment. Technical Report: Coil embolization was initially performed with little impact on the hemorrhage. A 7 x 40 mm Fluency® Plus covered stent (Bard Peripheral Vascular, Tempe, Arizona, USA) was placed and was supplemented by a second 8 x 40 mm Fluency Plus stent, with resulting cessation of active contrast extravasation. Discussion: The risks and benefits of various treatment options of carotid pseudoaneurysm with blowout are discussed including the use or omission of antiplatelet and anticoagulant regimens, with reference to previously reported cases. Conclusion: Tandem, overlapping covered stent placement in the common carotid artery is feasible and offers a treatment option for carotid blowout syndrome. Risks of aggravation of hemorrhage versus long-term thromboembolic events without antiplatelet therapy must be considered in cases of active ongoing hemorrhage. PMID:22518207

Accuracy of tracking forest machines with GPS

Treesearch

M.W. Veal; S.E. Taylor; T.P. McDonald; D.K. McLemore; M.R. Dunn

2001-01-01

This paper describes the results of a study that measured the accuracy of using GPS to track movement of forest machines. Two different commercially available GPS receivers (Trimble ProXR and GeoExplorer II) were used to track\\r\

Oregon Cascades Play Fairway Analysis: Maps

DOE Data Explorer

Trimble, John

2015-12-15

The maps in this submission include: heat flow, alkalinity, Cl, Mg, SiO2, Quaternary volcanic rocks, faults, and land ownership. All of the Oregon Cascade region. The work was done by John Trimble, in 2015, at Oregon State University.

Special electronic distance meter calibration for precise engineering surveying industrial applications

NASA Astrophysics Data System (ADS)

Braun, Jaroslav; Štroner, Martin; Urban, Rudolf

2015-05-01

All surveying instruments and their measurements suffer from some errors. To refine the measurement results, it is necessary to use procedures restricting influence of the instrument errors on the measured values or to implement numerical corrections. In precise engineering surveying industrial applications the accuracy of the distances usually realized on relatively short distance is a key parameter limiting the resulting accuracy of the determined values (coordinates, etc.). To determine the size of systematic and random errors of the measured distances were made test with the idea of the suppression of the random error by the averaging of the repeating measurement, and reducing systematic errors influence of by identifying their absolute size on the absolute baseline realized in geodetic laboratory at the Faculty of Civil Engineering CTU in Prague. The 16 concrete pillars with forced centerings were set up and the absolute distances between the points were determined with a standard deviation of 0.02 millimetre using a Leica Absolute Tracker AT401. For any distance measured by the calibrated instruments (up to the length of the testing baseline, i.e. 38.6 m) can now be determined the size of error correction of the distance meter in two ways: Firstly by the interpolation on the raw data, or secondly using correction function derived by previous FFT transformation usage. The quality of this calibration and correction procedure was tested on three instruments (Trimble S6 HP, Topcon GPT-7501, Trimble M3) experimentally using Leica Absolute Tracker AT401. By the correction procedure was the standard deviation of the measured distances reduced significantly to less than 0.6 mm. In case of Topcon GPT-7501 is the nominal standard deviation 2 mm, achieved (without corrections) 2.8 mm and after corrections 0.55 mm; in case of Trimble M3 is nominal standard deviation 3 mm, achieved (without corrections) 1.1 mm and after corrections 0.58 mm; and finally in case of Trimble S6 is nominal standard deviation 1 mm, achieved (without corrections) 1.2 mm and after corrections 0.51 mm. Proposed procedure of the calibration and correction is in our opinion very suitable for increasing of the accuracy of the electronic distance measurement and allows the use of the common surveying instrument to achieve uncommonly high precision.

The Scalar Resonances a0/f0(980) at COSY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buescher, M.

2006-02-11

Fundamental properties of the scalar resonances a0/f0(980), like their masses, widths and couplings to KK-bar, are poorly known. In particular, precise knowledge of the latter quantity would be of great importance since it can be related to the KK-bar content of these resonances.An experimental program is under way at COSY-Juelich aiming at the extraction of the isospin violating a0/f0 mixing amplitude {lambda} which is in leading order proportional to the product of the coupling constants of the a0 and f0 to kaons. a0/f0 production is studied in pp, pn and dd interactions, both for the KK-bar and the {pi}{eta}/{pi}{pi} decays,more » using the ANKE and WASA spectrometers. The latter will be available for measurements at COSY in 2007.As a first step, isovector KK-bar production has been measured in the reaction pp {yields} dK+K-bar0. The data reveal dominance of the a{sub 0}{sup +} channel, thus demonstrating the feasibility of scalar meson studies at COSY. Analyses of KK-bar- and K-bard-FSI effects yield the corresponding scattering lengths, a(KK-bar)I=1 = -(0.02 {+-} 0.03) - i(0.61 {+-} 0.05) fm and vertical bar Re a(K-bard) vertical bar {<=}1.3 fm, Im a(K-bard){<=}1.3 fm.« less

Comparison of FIB-4 index, NAFLD fibrosis score and BARD score for prediction of advanced fibrosis in adult patients with non-alcoholic fatty liver disease: A meta-analysis study.

PubMed

Sun, Wenjing; Cui, Hongli; Li, Ning; Wei, Yanling; Lai, Shujie; Yang, Yang; Yin, Xinru; Chen, Dong-Feng

2016-08-01

Non-alcoholic fatty liver disease (NAFLD)-related advanced hepatic fibrosis is associated with liver and cardiovascular morbidity and mortality. This study aims to compare the FIB-4 index, NAFLD fibrosis score (NFS) and BARD score for prediction of advanced liver fibrosis. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), summary receiver-operator curves (SROC) and Spearman's rank correlation coefficient were used to examine the accuracy of each non-invasive scoring system for predicting NAFLD-related advanced fibrosis. Four studies with 1038 adult patients were included in this meta-analysis. A total of 135 patients (13.0%) had advanced fibrosis. In the FIB-4 index group, pooled sensitivity and specificity with 95% confidence interval (CI), and the area under the ROC (AUROC) were 0.844 (0.772-0.901), 0.685 (0.654-0.716) and 0.8496 ± 0.0680, respectively, at a cut-off of 1.30. At a threshold of 3.25, the same parameters were 0.38 (0.30-0.47), 0.96 (0.95-0.98) and 0.8445 ± 0.0981. At a cut-off of -1.455, values were 0.77 (0.69-0.84), 0.70 (0.67-0.73) and 0.8355 ± 0.0667, respectively. At a 0.676 cut-off, pooled sensitivity and specificity with 95% CI were 0.27 (0.19-0.35) and 0.98 (0.96-0.98), respectively; and the AUROC was 0.647 ± 0.2208. In the BARD score group, pooled sensitivity and specificity with 95% CI were 0.74 (0.66-0.81) and 0.66 (0.63-0.69), respectively; and the AUROC was 0.7625 ± 0.0285. FIB-4 index with a 1.30 cut-off has better diagnostic accuracy than the FIB-4 index with a 3.25 cut-off, NFS and BARD score, despite showing its limited value for predicting NAFLD-related advanced fibrosis. © 2016 The Japan Society of Hepatology.

Louisville Gas & Electric Trimble Power Station; Petition to Object to REVISED Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Integrating Archaeological Modeling in DoD Cultural Resource Compliance

DTIC Science & Technology

2012-10-26

Leo 2001 Random Forests. Machine Learning 45:5–32. Briuer, Frederick, Clifford Brown, Alan Gillespie, Fredrick Limp, Michael Trimble, and Len...glaciolacustrine clays on glacial lake plains Inceptisols Very-fine, mixed, active, nonacid, mesic Mollic Endoaquepts Low to none LoC Lowville silt

75 FR 62115 - Energy Conservation Program for Consumer Products: Commonwealth of Massachusetts Petition for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... requirements. Examples of these requirements cited by Massachusetts include its Global Warming Solutions Act...), Bard Manufacturing Company Inc., Carrier Residential and Light Commercial Systems, Goodman Global Inc...

Subscale Glider Could Assist in Weather Studies, Prediction

NASA Image and Video Library

2017-01-30

The WHAATRR team from NASA Armstrong includes, from left, Derek Abramson Dave Berger, John Bodylski, Robert “Red” Jensen, Scott Wiley, Al Bowers, Justin Hall, Luke Bard, Hussein Nasr and Samantha Ingersoll.

SU(2) Flavor Asymmetry of the Proton Sea in Chiral Effective Theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKenney, J. R.; Sato Gonzalez, Nobuo; Melnitchouk, Wally

We refine the computation of themore » $$\\bar{d}$$ - $$\\bar{u}$$ flavor asymmetry in the proton sea with a complementary effort to reveal the dynamics of pion exchange in high-energy processes. In particular, we discuss the efficacy of pion exchange models to simultaneously describe leading neutron electroproduction at HERA along with the $$\\bar{d}$$ - $$\\bar{u}$$ flavor asymmetry in the proton. A detailed χ 2 analysis of the ZEUS and H1 data, when combined with constraints on the pion flux from Drell-Yan data, allows regions of applicability of one-pion exchange to be delineated. Based on the fit results, we also address a possible estimate for leading proton structure functions in upcoming tagged deep-inelastic scattering experiments at Jefferson Lab on the deuteron with forward protons.« less

Bards and Beatles: Connecting Spontaneity to Structure in Lesson Plans.

ERIC Educational Resources Information Center

Cox, Mitch

1991-01-01

Describes how one teacher provides minimally structured lessons that encourage senior high school students to carry their learning beyond the classroom. Describes units on business communication, research, British literature, and independent reading. (MG)

Using Google SketchUp to simulate tree row azimuth effects on alley shading

USDA-ARS?s Scientific Manuscript database

Effect of row azimuth on alley crop illumination is difficult to determine empirically. Our objective was to determine if Google SketchUp (Trimble Inc., Sunnyvale, CA) could be used to simulate effect of azimuth orientation on illumination of loblolly pine (Pinus taeda L.) alleys. Simulations were...

NCI and the Chinese National Cancer Center pursue new collaborations in cancer research

Cancer.gov

CGH Director, Dr. Ted Trimble, and East Asia Program Director, Dr. Ann Chao, traveled to Beijing with Mr. Matthew Brown from the Department of Health and Human Services Office of Global Affairs to attend the Joint Meeting of the NCC and the U.S. NCI.

The Nature and Significance of Surveys

NASA Astrophysics Data System (ADS)

Trimble, V.

We present here some of the ideas and questions mentioned by the panelists and other participants during the discussion that immediately preceded Ofer Lahav's concluding remarks. Official panelists were George Djorgovski, Michael Disney, Ofer Lahav, and Virginia Trimble (chair). The topics of the posters are very briefly summarized as well.

Gestational Age, Infant Birth Weight, and Subsequent Risk of Type 2 Diabetes in Mothers: Nurses' Health Study II

MedlinePlus

... 401. CrossRef PubMed Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. ... 805. CrossRef PubMed Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, et al. Markers ...

High Resolution Multispectral and Hyperspectral Data Fusion for Advanced Geospatial Information Products

DTIC Science & Technology

2007-03-01

instrumentation was provided under a cooperative agreement with the Applanix Systems Integration Group (ASIG), a subsidiary of the Trimble Corporation. This MSI...system (Digital Sensor System; http://www.applanix.com/products/dss index.php) was provided as part of the Applanix Position and Orientation System (POS

Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

ScienceCinema

Moniz, Ernest; Dehmer, Patricia

2018-05-04

The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of the research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.

Enrico Fermi Awards Ceremony for Dr. Allen J. Bard and Dr. Andrew Sessler, February 2014 (Presentations, including remarks by Energy Secretary, Dr. Ernest Moniz)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moniz, Ernest; Dehmer, Patricia

The Fermi Award is a Presidential award and is one of the oldest and most prestigious science and technology honors bestowed by the U.S. Government. On February 3, 2014 it was conferred upon two exceptional scientists. The first to be recognized is Dr. Allen J. Bard, 'for international leadership in electrochemical science and technology, for advances in photoelectrochemistry and photocatalytic materials, processes, and devices, and for discovery and development of electrochemical methods including electrogenerated chemiluminescence and scanning electrochemical microscopy.' The other honoree is Dr. Andrew Sessler, 'for advancing accelerators as powerful tools of scientific discovery, for visionary direction of themore » research enterprise focused on challenges in energy and the environment, and for championing outreach and freedom of scientific inquiry worldwide.' Dr. Patricia Dehmer opened the ceremony, and Dr. Ernest Moniz presented the awards.« less

An Analysis of the Influence of Flight Parameters in the Generation of Unmanned Aerial Vehicle (UAV) Orthomosaicks to Survey Archaeological Areas.

PubMed

Mesas-Carrascosa, Francisco-Javier; Notario García, María Dolores; Meroño de Larriva, Jose Emilio; García-Ferrer, Alfonso

2016-11-01

This article describes the configuration and technical specifications of a multi-rotor unmanned aerial vehicle (UAV) using a red-green-blue (RGB) sensor for the acquisition of images needed for the production of orthomosaics to be used in archaeological applications. Several flight missions were programmed as follows: flight altitudes at 30, 40, 50, 60, 70 and 80 m above ground level; two forward and side overlap settings (80%-50% and 70%-40%); and the use, or lack thereof, of ground control points. These settings were chosen to analyze their influence on the spatial quality of orthomosaicked images processed by Inpho UASMaster (Trimble, CA, USA). Changes in illumination over the study area, its impact on flight duration, and how it relates to these settings is also considered. The combined effect of these parameters on spatial quality is presented as well, defining a ratio between ground sample distance of UAV images and expected root mean square of a UAV orthomosaick. The results indicate that a balance between all the proposed parameters is useful for optimizing mission planning and image processing, altitude above ground level (AGL) being main parameter because of its influence on root mean square error (RMSE).

An Analysis of the Influence of Flight Parameters in the Generation of Unmanned Aerial Vehicle (UAV) Orthomosaicks to Survey Archaeological Areas

PubMed Central

Mesas-Carrascosa, Francisco-Javier; Notario García, María Dolores; Meroño de Larriva, Jose Emilio; García-Ferrer, Alfonso

2016-01-01

This article describes the configuration and technical specifications of a multi-rotor unmanned aerial vehicle (UAV) using a red–green–blue (RGB) sensor for the acquisition of images needed for the production of orthomosaics to be used in archaeological applications. Several flight missions were programmed as follows: flight altitudes at 30, 40, 50, 60, 70 and 80 m above ground level; two forward and side overlap settings (80%–50% and 70%–40%); and the use, or lack thereof, of ground control points. These settings were chosen to analyze their influence on the spatial quality of orthomosaicked images processed by Inpho UASMaster (Trimble, CA, USA). Changes in illumination over the study area, its impact on flight duration, and how it relates to these settings is also considered. The combined effect of these parameters on spatial quality is presented as well, defining a ratio between ground sample distance of UAV images and expected root mean square of a UAV orthomosaick. The results indicate that a balance between all the proposed parameters is useful for optimizing mission planning and image processing, altitude above ground level (AGL) being main parameter because of its influence on root mean square error (RMSE). PMID:27809293

Starting time for induction of labor and the risk for night-time delivery.

PubMed

Thorsell, M; Lyrenäs, S; Andolf, E; Kaijser, M

2011-08-01

To analyze if starting time for labor induction affected the risk of night-time delivery, and to evaluate to what extent the risk was influenced by Bishop score at start of induction, mode of induction, and parity. A retrospective cohort study of women who delivered at Danderyd Hospital, Stockholm, Sweden, 2002-2006, comprising 1940 women induced by Dinoprostone (PGE(2)) or transcervical balloon catheter (BARD). Risks for night-time delivery were calculated as absolute risk and Odds Ratios by unconditional logistic regression using induction of labor in the morning as reference. For nulliparae with Bishop score 0-3 induced by BARD, odds ratios for night-time delivery were 0.42 (95% C.I. 0.19-0.93) and 0.09 (95% C.I. 0.02-0.47) when inductions started in the afternoon and evening, respectively, compared to inductions starting in the morning For multiparae, however, the risk of night-time delivery was highest if induction started in the evening. Compared to inductions started in the morning, odds ratios for night-time delivery were 3.53 (95% C.I. 2.57-4.83) and 8.49 (95% C.I. 4.45-16.19) for induction starting in the afternoon and evening, respectively. Starting time of labor induction affects the risk of giving birth at night. For nulliparae induced by BARD, starting the induction in the evening instead of during the day may reduce the number of night-time deliveries substantially. For multiparae, however, our data suggest that induction of labor should take place in the morning. Copyright © 2011 Elsevier B.V. All rights reserved.

Port type is a possible risk factor for implantable venous access port-related bloodstream infections and no sign of local infection predicts the growth of gram-negative bacilli.

PubMed

Hsu, Jui-Feng; Chang, Hsu-Liang; Tsai, Ming-Ju; Tsai, Ying-Ming; Lee, Yen-Lung; Chen, Pei-Huan; Fan, Wen-Chieh; Su, Yu-Chung; Yang, Chih-Jen

2015-09-30

Implantable venous access port (IVAP)-related blood stream infections (BSIs) are one of the most common complications of implantable venous ports. The risk factors and pathogens for IVAP-related BSIs are still controversial. We retrospectively reviewed all patients who received IVAPs at a Hospital in Taiwan from January 1, 2011 to June 31, 2014. Two types of venous port, BardPort® 6.6 fr (Bard port) and Autosuture Chemosite® 7.5 fr (TYCO port) were used. All patients with clinically proven venous port-related BSIs were enrolled. A total of 552 patients were enrolled. There were 34 episodes of IVAP-related BSIs during the study period for a total incidence of 0.177 events/1000 catheter days. Port type (TYCO vs. Bard, HR = 7.105 (95% confidence interval (CI), 1.688-29.904), p = 0.0075), age > 65 years (HR = 2.320 (95 % CI, 1.179-4.564), p = 0.0148), and lung cancer (HR = 5.807 (95% CI, 2.946-11.447), p < 0.001) were risk factors for port infections. We also found that no local sign of infection was significantly associated with the growth of gram-negative bacilli (p = 0.031). TYCO venous ports, age > 65 years, and lung cancer were all significant risk factors for IVAP-related BSIs, and no sign of infection was significantly associated with the growth of gram-negative bacilli.

Dalitz plot analysis of the decay B 0 ( B ¯ 0 ) → K ± π ∓ π 0

DOE PAGES

Aubert, B.; Bona, M.; Karyotakis, Y.; ...

2008-09-12

Here, we report a Dalitz-plot analysis of the charmless hadronic decays of neutral B mesons to K ± π ∓ π 0 . With a sample of ( 231.8 ± 2.6 ) × 10 6 Υ ( 4 S ) → Bmore » $$\\bar{B}$$ decays collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC, we measure the magnitudes and phases of the intermediate resonant and nonresonant amplitudes for B 0 and $$\\bar{B}$$ 0 decays and determine the corresponding C P -averaged branching fractions and charge asymmetries. Furthermore, we measure the inclusive branching fraction and C P -violating charge asymmetry and found it to be B ( B 0 → K + π - π 0 ) = ( 35.7$$+2.6\\atop{-1.5}$$ + 2.6 - 1.5 ± 2.2 ) × 10 - 6 and A C P = - 0.030 $$+ 0.045\\atop{- 0.051}$$ ± 0.055 where the first errors are statistical and the second systematic. We observe the decay B 0 → K * 0 ( 892 ) π 0 with the branching fraction B ( B 0 → K * 0 ( 892 ) π 0 ) = ( 3.6 $$+ 0.7\\atop- {0.8}$$ ± 0.4 ) × 10 - 6 . This measurement differs from zero by 5.6 standard deviations (including the systematic uncertainties). The selected sample also contains B 0 → $$\\bar{D}$$ 0 π 0 decays where $$\\bar{D}$$ 0 → K + π - , and we measure B ( B 0 → $$\\bar{D}$$ 0π 0 ) = ( 2.93 ± 0.17 ± 0.18 ) × 10 - 4 .« less

Air Force Internal Control Systems: A Proposal for Improvement.

DTIC Science & Technology

1986-09-01

Wrong. Idea Paper, LD 51636A, PMCS 82-C, August 1982. 66. Marler , Kenneth E. Implementation of the Federal Managers’ Financial Integrity Act of 1982 in... Eric V. Can Internal Review Support A Manage- ment Development Program? Idea Paper, LD 47951A, PMCS 81-A, December 1980. 91. Trimble, Robert C., Jr

Louisville Gas & Electric Trimble Power Station; Partial Order Denying in Part and Granting in Part Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

77 FR 2557 - National Cancer Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-18

... 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions could disclose... Subcommittee on Global Cancer Research. Open: February 27, 2012, 6:30 p.m. to 8 p.m. Agenda: Discussion on.... Contact Person: Dr. Ted Trimble, Executive Secretary, NCAB Ad hoc Subcommittee on Global Cancer Research...

76 FR 66733 - National Cancer Institute; Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... 552b(c)(6), Title 5 U.S.C., as amended for the review, discussion, and evaluation of individual... Cancer Advisory Board, Subcommittee on Global Cancer Research. Open: December 5, 2011, 6:30 p.m. to 8 p.m.... Contact Person: Dr. Ted Trimble, Executive Secretary, NCAB Subcommittee on Global Cancer Research...

A Touchstone for the Bard.

ERIC Educational Resources Information Center

Elliot, W. E. Y.; Valenza, R. J.

1991-01-01

Discusses the authorship of literary works attributed to William Shakespeare. Describes the "modal analysis" authorship identification test's application to the dispute. Concludes that the poems, "Shall I Die" and "Elegy," may not have been written by Shakespeare, whereas eight poems from the collection, "The…

Accuracy of Tracking Forest Machines with GPS

Treesearch

M.W. Veal; S.E. Taylor; T.P. McDonald; D.K. McLemore; M.R. Dunn

2001-01-01

This paper describes the results of a study that measured the accuracy of using GPS to track movement offorest machines. Two different commercially available GPS receivers (Trimble ProXR and GeoExplorer II) were used to track wheeled skidders under three different canopy conditions at two different vehicle speeds. Dynamic GPS data were compared to position data...

Defense Innovation Unit Experimental (DIUX): Innovative or Excessive

DTIC Science & Technology

2017-04-06

DIUx, and the short history of DIUx. Innovation principles from authors Vijay Govindarajan, Michael Docherty, and Clayton Christensen are then...innovation principles such as performance engine & innovative team, collective / open innovation, and disruptive technology and its implications – is...various innovation principles drawing primarily from work by authors Vijay Govindarajan and Chris Trimble, Michael Docherty, and Clayton Christenson

Louisville Gas & Electric Trimble Power Station; Partial Order Denying in Part and Granting in Part March 2, 2006 Petition to Object to Title V Operating Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database.

Predicting inferior vena cava (IVC) filter retrievability using positional parameters: A comparative study of various filter types.

PubMed

Gotra, A; Doucet, C; Delli Fraine, P; Bessissow, A; Dey, C; Gallix, B; Boucher, L-M; Valenti, D

2018-05-14

To compare changes in inferior vena cava (IVC) filter positional parameters from insertion to removal and examine how they affect retrievability amongst various filter types. A total of 447 patients (260 men, 187 women) with a mean age of 55 years (range: 13-91 years) who underwent IVC filter retrieval between 2007-2014 were retrospectively included. Post-insertion and pre-retrieval angiographic studies were assessed for filter tilt, migration, strut wall penetration and retrieval outcomes. ANCOVA and multiple logistic regression models were used to analyze factors affecting retrieval success. Pairwise comparisons between filter types were performed. Of 488 IVC filter retrieval attempts, 94.1% were ultimately successful. The ALN filter had the highest mean absolute value of tilt (5.6 degrees), the Optease filter demonstrated the largest mean migration (-8.0mm) and the Bard G2 filter showed highest mean penetration (5.2mm). Dwell time of 0-90 days (OR, 11.1; P=0.01) or 90-180 days (OR, 2.6; P=0.02), net tilt of 10-15 degrees (OR 8.9; P=0.05), caudal migration of -10 to 0mm (OR, 3.46; P=0.03) and penetration less than 3mm (OR, 2.6; P=0.01) were positive predictors of successful retrievability. Higher odds of successful retrieval were obtained for the Bard G2X, Bard G2 and Cook Celect when compared to the ALN and Cordis Optease filters. Shorter dwell time, lower mean tilt, caudal migration and less caval wall penetration are positive predictors of successful IVC filter retrieval. Copyright © 2018 Société française de radiologie. Published by Elsevier Masson SAS. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muryn, J; Wilkinson, D

Purpose: The purpose of this work is to evaluate a method for confirming source strength of I-125 seeds in a bulk assay while maintaining sterility and time efficiency. Methods: The I-125 seeds used in this study (STM 1251, Bard Brachytherapy, Inc.) were available as loose seeds or linked in 3, 4, or 5 seed configurations. A third party 10% assay (NIST traceable) is provided. Source strengths ranging from 0.395 to 0.504 U were available for this study. A stand was built out of aluminum to hold an exposure meter (Inovision (Fluke) 451P) at 25 cm above the I-125 sources tomore » measure the exposure rate. Three different seed configurations were measured: loose, linked, and loaded needles (Bard FastFil Seed Implant Needle). The measurements were made in an operating room, and a sterile sheet was used under the non-sterile aluminum stand. Seeds and needles were placed in a sterile tray. Results: One hundred forty-two loose seeds in 5 batches (0.395, 0.395, 0.409, 0.444, 0.444 U/seed) and 902 seeds in 7 batches containing various strands (0.444, 0.444,.0444, 0.466, 0.466, 0.504, 0.504 U/seed) were measured. The average exposure rate per unit activity was measured to be 0.593 mR per hr per U with a standard deviation of 0.016. The Result for loaded needles was 0.261 mR per hr per U with a standard deviation of 0.014. Once the apparatus is set up, measurements of 180 linked sources as supplied in the Bard package requires only a few minutes. Conclusion: The proposed method can confirm the activity of a batch of loose or stranded I-125 seeds within a range of 5%.« less

The President as Bard.

ERIC Educational Resources Information Center

Kingsley, J. Gordon

1987-01-01

The role of the college president is described as that of "the solitary singer galvanizing a people to noble, even heroic action by the power of Their Story." The president spends his or her life trying to embody and fulfill the dreams, hopes, and aspirations of the college. (MLW)

Who are the Millennials?

DTIC Science & Technology

2010-12-01

CDs that have adult themed lyrics (Vogel, 2001; DeBard, 2004; Vogt, 2005; Epstein & Howes, 2006; NAS, 2006). Parents of Millennials are also highly...www.lifecourse.com/news/millennialssurvey.php, Accessed 24 July 2007 Mannheim, K. (1928), “On the Problem of Generations”, in Essays on the Sociology of

Posterior repair with perforated porcine dermal graft.

PubMed

Taylor, G Bernard; Moore, Robert D; Miklos, John R; Mattox, T Fleming

2008-01-01

To compare postoperative vaginal incision separation and healing in patients undergoing posterior repair with perforated porcine dermal grafts with those that received grafts without perforations. Secondarily, the tensile properties of the perforated and non-perforated grafts were measured and compared. This was a non-randomized retrospective cohort analysis of women with stage II or greater rectoceles who underwent posterior repair with perforated and non-perforated porcine dermal grafts (Pelvicol(TM) CR Bard Covington, GA USA). The incidence of postoperative vaginal incision separation (dehiscence) was compared. A secondary analysis to assess graft tensile strength, suture pull out strength, and flexibility after perforation was performed using standard test method TM 0133 and ASTM bending and resistance protocols. Seventeen percent of patients (21/127) who received grafts without perforations developed vaginal incision dehiscence compared to 7% (5/71) of patients who received perforated grafts (p = 0.078). Four patients with vaginal incision dehiscence with non-perforated grafts required surgical revision to facilitate healing. Neither tensile strength or suture pull out strength were significantly different between perforated and non-perforated grafts (p = 0.81, p = 0.29, respectively). There was no difference in the flexibility of the two grafts (p = 0.20). Perforated porcine dermal grafts retain their tensile properties and are associated with fewer vaginal incision dehiscences.

Innovative Navigation Systems to Support Digital Geophysical Mapping

DTIC Science & Technology

2004-02-01

9 Figure 8. Blackhawk/ Applanix GPS/INS System.................................................................10 Figure 9. Figure-Eight Traverse...Vulcan/LaserStation Line-of-sight laser Parsons Trimble INS/GPS DGPS and inertia guidance Blackhawk Applanix INS/GPS DGPS and inertia guidance...The Applanix Positioning and Orientation System for Land Survey (POS/LS) was used for the Phase I work. The system is similar to the Parsons

The Bard in the Bathroom: Literary Analysis, Filmmaking, and Shakespeare

ERIC Educational Resources Information Center

Bucolo, Joe

2007-01-01

Drawing on the expertise of colleagues in technology and filmmaking, high school teacher Joe Bucolo helps students demonstrate the critical comprehension, mastery, and creative insight that transpire from close study of Shakespeare's plays. Production Teams examine the context and language of Shakespeare's scenes, interview an expert, and address…

The Chortling Bard: Caught'ya Grammar with a Giggle for High School Students.

ERIC Educational Resources Information Center

Kiester, Jane Bell

This book transforms William Shakespeare's "Twelfth Night,""A Midsummer Night's Dream," and "Much Ado about Nothing" into adaptable "Caught'ya" sentences that appeal to high school students at any level--from basic skills and dropout prevention through high honors and advanced placement. The book makes…

Egyptian Sea Cave

ERIC Educational Resources Information Center

Journal of College Science Teaching, 2005

2005-01-01

This brief article describes an archaeological expedition to the Red Sea coast area of Egypt in 2004. Kathryn Bard, an associate professor of archaeology at Boston University, along with her team, discovered the well-preserved cedar timbers of an ancient Egyptian seafaring vessel near the entrance to a large man-made cave. Limestone tablets with…

Humanizing Shakespeare.

ERIC Educational Resources Information Center

Bernstein, Abraham

The task of humanizing Shakespeare for high school seniors is not simple but may be done in a variety of ways, all intended to arouse student interest, curiosity, respect, and fondness for the Bard. Gimmicks such as bulletin board signs, pictures, maps, charts, and writings attract attention, as do letters to local newspapers reporting informally…

UNAVCO Real-Time GNSS Positioning: High-Precision Static and Kinematic Testing of the Next Generation GNSS network.

NASA Astrophysics Data System (ADS)

Berglund, H. T.; Hodgkinson, K. M.; Blume, F.; Mencin, D.; Phillips, D. A.; Meertens, C. M.; Mattioli, G. S.

2014-12-01

The GAGE Facility, managed by UNAVCO, operates a real-time GNSS (RT-GNSS) network of ~450 stations. The majority of the streaming stations are part of the EarthScope Plate Boundary Observatory (PBO). Following community input from a real-time GNSS data products and formats meeting hosted by UNAVCO in Spring of 2011, UNAVCO now provides real-time PPP positions, and network solutions where practical, for all available stations using Trimble's PIVOT RTX server software and TrackRT. The UNAVCO real-time system has the potential to enhance our understanding of earthquakes, seismic wave propagation, volcanic eruptions, magmatic intrusions, movement of ice, landslides, and the dynamics of the atmosphere. Beyond the ever increasing applications in science and engineering, RT-GNSS has the potential to provide early warning of hazards to emergency managers, utilities, other infrastructure managers, first responders and others. Upgrades to the network include eight Trimble NetR9 GNSS receivers with GLONASS and receiver-based RTX capabilities and sixteen new co-located MEMS based accelerometers. These new capabilities will allow integration of GNSS and strong motion data to produce broad-spectrum waveforms improving Earthquake Early Warning systems. Controlled outdoor kinematic and static experiments provide a useful method for evaluating and comparing real-time systems. UNAVCO has developed a portable low-cost antenna actuator to characterize the kinematic performance of receiver- and server-based real-time positioning algorithms and identify system limitations. We have performed tests using controlled 1-d antenna motions and will present comparisons between these and other post-processed kinematic algorithms including GIPSY-OASIS and TRACK. In addition to kinematic testing, long-term static testing of Trimble's RTX service is ongoing at UNAVCO and will be used to characterize the stability of the position time-series produced by RTX. In addition, with the goal of characterizing stability and improving software and higher level products based on real-time and high frequency GNSS time series, we present an overview of the UNAVCO RT-GPS system, a comparison of the UNAVCO generated real-time, static and community data products, and an overview of available common data sets.

Hazard Monitoring in a Spectrum-Challenged Future: US Department of Transportation Adjacent Band Compatibility Assessment of Interference on High-Precision GNSS Receivers

NASA Astrophysics Data System (ADS)

Blume, F.; Berglund, H. T.

2016-12-01

In 2012 the Federal Communications Commission (FCC) reversed its decision to allow communications company LightSquared to use GPS-adjacent spectrum for a ground based network after testing demonstrated harmful interference to GPS receivers. Now rebranded as Ligado, they have submitted modified application to use a smaller portion of the L-band spectrum at much lower power. Many GPS community stakeholders, including the hazard monitoring and EEW communities remain concerned that Ligado's proposed use could still cause harmful interference, causing signal degradation, real-time positioning errors, and total failure of GNSS hardware in widespread use in hazard monitoring networks. The Department of Transportation (DoT) has conducted hardware tests to determine adjacent-band transmitter power limit criteria that would prevent harmful interference from Ligado's operations. We present preliminary results produced from the data collected by the three UNAVCO receiver types tested: Trimble NetRS, Trimble NetR9, and Septentrio PolaRx5. In the first round of testing, simulated GNSS signals were broadcast in an anechoic chamber (pictured below) while interfering signals are broadcast simultaneously with varying amplitude and frequency. The older GPS-only NetRS receiver showed smaller reductions in SNR at frequencies adjacent to GPS L1 as compared to the other receivers, suggesting narrower L1 filter bandwidth in the RF frontend. The NetR9 showed greater decreases in observed SNR in the 1615 to 1625 MHz range when compared to the other two receivers. This suggests that the NetR9's L1 filter bandwidth has been increased to accommodate GNSS signals. Linearity tests were conducted to better relate SNR measurements between receiver types. The PolaRx5 receiver showed less SNR variation between tracking channels than both Trimble receivers. Our results show the power levels at which adjacent-band interference begins degrading receiver performance and eventually disables tracking. As the demand for spectrum for mobile applications increases, operators of hazard networks may need to consider the impact of RF interference on data quality and continuity. UNAVCO's participation ensures that our high precision GNSS community interests are represented in the future spectrum allocation decisions.

Writing-Based Teaching: Essential Practices and Enduring Questions

ERIC Educational Resources Information Center

Vilardi, Teresa, Ed.; Chang, Mary, Ed.

2009-01-01

Written by the team at Bard College's Institute for Writing and Thinking, this book is designed to provide practical guidance regarding the challenges and potential of writing-based teaching, and suggestions for how to adapt the practices to particular classroom situations. The contributors share candid, first-hand accounts of what it is like to…

Great Scenes From Shakespeare: An Introduction to the Bard.

ERIC Educational Resources Information Center

Carter, Candy

An introductory unit on Shakespeare suitable for grades 8-10 is described. (The unit is intended for use with "A Visual Guide to Shakespeare's Life and Times" (Washington Square Press) and "Kings, Lovers, and Fools" (Scholastic). Activities include a 3-page study guide on Shakespeare's life and times; a chart for recording the…

The neurology in Shakespeare.

PubMed

Fogan, L

1989-08-01

William Shakespeare's 37 plays and poetry contain many references of interest for almost all of the medical specialties. To support that the Bard could be considered a Renaissance neurologist, the following important neurological phenomena have been selected from his repertoire for discussion: tremors, paralysis and stroke, sleep disturbances, epilepsy, dementia, encephalopathies, and the neurology of syphilis.

Puck in the Schoolyard: Crassing the Bard at Hawthorn Secondary College.

ERIC Educational Resources Information Center

Hayes, Terry

1999-01-01

Claims doing "A Midsummer Night's Dream" as a school production allows students to bring their own personalities and cultures into the play. Explains how the production can be both inclusive, making room for many extra actions, as well communal, vivifying a school community to make it live more intensely. (NH)

Bringing in the Bard: Shakespearean Plays as Context for Instrumental Analysis Projects

ERIC Educational Resources Information Center

Kloepper, Kathryn D.

2015-01-01

Scenes from the works of William Shakespeare were incorporated into individual and group projects for an upper-level chemistry class, instrumental analysis. Students read excerpts from different plays and then viewed a corresponding video clip from a stage or movie production. Guided-research assignments were developed based on these scenes. These…

Shakespeare of Hollywood: The Bard and the Beautiful.

ERIC Educational Resources Information Center

Rollin, Roger B.

This document describes seven distinct factors that affect the popularity of movies, using, as examples, the seven movies based on Shakespeare's work that have been produced since World War II. The seven factors, each of which is assigned a relative numerical weight, are formal publicity, or the money spent on accountable advertising such as that…

Why High School Must Go: An Interview with Leon Botstein

ERIC Educational Resources Information Center

Epstein, Robert

2007-01-01

This article presents an interview with Leon Botstein, longtime president of Bard College, as well as music director and conductor of the American and Jerusalem symphony orchestras. Botstein talks about his book entitled "Jefferson's Children: Education and the Promise of American Culture" and his views about teens and high schools in America.…

Conventional fascial technique versus mesh repair for advanced pelvic organ prolapse: Analysis of recurrences in treated and untreated compartments.

PubMed

Damiani, G R; Riva, D; Pellegrino, A; Gaetani, M; Tafuri, S; Turoli, D; Croce, P; Loverro, G

2016-01-01

117 women with severe pelvic organ prolapse (POP; stage > 2) were enrolled to elucidate a 24-month outcome of POP surgery, using conventional or mesh repair with 3 techniques. 59 patients underwent conventional repair and 58 underwent mesh repair. Two types of mesh were used: a trocar-guided transobturator polypropylene (Avaulta, Bard Inc.) and a porcine dermis mesh (Pelvisoft, Bard Inc.). Women with recurrences, who underwent previous unsuccessful conventional repair, were randomised. Primary outcome was the evaluation of anatomic failures (prolapse stage > 1) in treated and untreated compartments. Anatomic failure was observed in 11 of 58 patients (19%; CI 8.9-29) in the mesh group and in 16 of 59 patients (27.1%; p value = 0.3) in the conventional group. 9 of 11 failures in the mesh group (15.5%; CI 6.2-24.8) were observed in the untreated compartment (de novo recurrences), 14.3% in Pelvisoft and 16.7% in Avaulta arm, while only 1 recurrence in the untreated compartment (1.7%) was observed in the conventional group (odds ratio 10.6, p = 0.03).

The Biosurveillance Analytics Resource Directory (BARD): Facilitating the use of epidemiological models for infectious disease surveillance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Margevicius, Kristen J.; Generous, Nicholas; Abeyta, Esteban

Epidemiological modeling for infectious disease is important for disease management and its routine implementation needs to be facilitated through better description of models in an operational context. A standardized model characterization process that allows selection or making manual comparisons of available models and their results is currently lacking. A key need is a universal framework to facilitate model description and understanding of its features. Los Alamos National Laboratory (LANL) has developed a comprehensive framework that can be used to characterize an infectious disease model in an operational context. The framework was developed through a consensus among a panel of subjectmore » matter experts. In this paper, we describe the framework, its application to model characterization, and the development of the Biosurveillance Analytics Resource Directory (BARD; http://brd.bsvgateway.org/brd/), to facilitate the rapid selection of operational models for specific infectious/communicable diseases. We offer this framework and associated database to stakeholders of the infectious disease modeling field as a tool for standardizing model description and facilitating the use of epidemiological models.« less

The Biosurveillance Analytics Resource Directory (BARD): Facilitating the Use of Epidemiological Models for Infectious Disease Surveillance

PubMed Central

Margevicius, Kristen J; Generous, Nicholas; Abeyta, Esteban; Althouse, Ben; Burkom, Howard; Castro, Lauren; Daughton, Ashlynn; Del Valle, Sara Y.; Fairchild, Geoffrey; Hyman, James M.; Kiang, Richard; Morse, Andrew P.; Pancerella, Carmen M.; Pullum, Laura; Ramanathan, Arvind; Schlegelmilch, Jeffrey; Scott, Aaron; Taylor-McCabe, Kirsten J; Vespignani, Alessandro; Deshpande, Alina

2016-01-01

Epidemiological modeling for infectious disease is important for disease management and its routine implementation needs to be facilitated through better description of models in an operational context. A standardized model characterization process that allows selection or making manual comparisons of available models and their results is currently lacking. A key need is a universal framework to facilitate model description and understanding of its features. Los Alamos National Laboratory (LANL) has developed a comprehensive framework that can be used to characterize an infectious disease model in an operational context. The framework was developed through a consensus among a panel of subject matter experts. In this paper, we describe the framework, its application to model characterization, and the development of the Biosurveillance Analytics Resource Directory (BARD; http://brd.bsvgateway.org/brd/), to facilitate the rapid selection of operational models for specific infectious/communicable diseases. We offer this framework and associated database to stakeholders of the infectious disease modeling field as a tool for standardizing model description and facilitating the use of epidemiological models. PMID:26820405

The Biosurveillance Analytics Resource Directory (BARD): Facilitating the Use of Epidemiological Models for Infectious Disease Surveillance.

PubMed

Margevicius, Kristen J; Generous, Nicholas; Abeyta, Esteban; Althouse, Ben; Burkom, Howard; Castro, Lauren; Daughton, Ashlynn; Del Valle, Sara Y; Fairchild, Geoffrey; Hyman, James M; Kiang, Richard; Morse, Andrew P; Pancerella, Carmen M; Pullum, Laura; Ramanathan, Arvind; Schlegelmilch, Jeffrey; Scott, Aaron; Taylor-McCabe, Kirsten J; Vespignani, Alessandro; Deshpande, Alina

2016-01-01

Epidemiological modeling for infectious disease is important for disease management and its routine implementation needs to be facilitated through better description of models in an operational context. A standardized model characterization process that allows selection or making manual comparisons of available models and their results is currently lacking. A key need is a universal framework to facilitate model description and understanding of its features. Los Alamos National Laboratory (LANL) has developed a comprehensive framework that can be used to characterize an infectious disease model in an operational context. The framework was developed through a consensus among a panel of subject matter experts. In this paper, we describe the framework, its application to model characterization, and the development of the Biosurveillance Analytics Resource Directory (BARD; http://brd.bsvgateway.org/brd/), to facilitate the rapid selection of operational models for specific infectious/communicable diseases. We offer this framework and associated database to stakeholders of the infectious disease modeling field as a tool for standardizing model description and facilitating the use of epidemiological models.

The Biosurveillance Analytics Resource Directory (BARD): Facilitating the use of epidemiological models for infectious disease surveillance

DOE PAGES

Margevicius, Kristen J.; Generous, Nicholas; Abeyta, Esteban; ...

2016-01-28

Epidemiological modeling for infectious disease is important for disease management and its routine implementation needs to be facilitated through better description of models in an operational context. A standardized model characterization process that allows selection or making manual comparisons of available models and their results is currently lacking. A key need is a universal framework to facilitate model description and understanding of its features. Los Alamos National Laboratory (LANL) has developed a comprehensive framework that can be used to characterize an infectious disease model in an operational context. The framework was developed through a consensus among a panel of subjectmore » matter experts. In this paper, we describe the framework, its application to model characterization, and the development of the Biosurveillance Analytics Resource Directory (BARD; http://brd.bsvgateway.org/brd/), to facilitate the rapid selection of operational models for specific infectious/communicable diseases. We offer this framework and associated database to stakeholders of the infectious disease modeling field as a tool for standardizing model description and facilitating the use of epidemiological models.« less

A single center experience with retrievable IVC filters.

PubMed

Renno, Anas; Khateeb, Faisal; Kazan, Viviane; Qu, Weikai; Gollapudi, Anurekha; Aplin, Brett; Abbas, Jihad; Zelenock, Gerald; Nazzal, Munier

2015-08-01

To evaluate retrievable IVC filters in our institution and assess their retrieval following a well-structured follow up program. Retrospective cohort study. The medical records of patients implanted with retrievable IVC filters were reviewed. All retrievable filter insertions between July 2007 and August 2011 at our institution were reviewed. Data was analyzed for age, gender, indication, complications, retrieval rate, and brand of filter inserted. Statistical analysis was done using SPSS software v19. Chi-square was used to compare discrete data and t-test for continuous data. P < 0.05 was significant. A total of 484 patients were reviewed of which 258 (53.1%) had a complete medical record. And 96 (37.2%) filters were placed as permanent at the time of insertion. An additional 40 (15.5%) filters were converted to permanent (total permanent filters 136; 52.7%). Death was reported in 26 (10%) patients and 96 (37.2%) out of the remaining 232 patients presented for potential retrieval. Also, 73 (28.2%) had an attempt to retrieve the filters, 69 (94.5%) were successful and 4 (5.4%) failed to retrieve. The remaining 23 (8.9%) patients declined retrieval. Filters studied include Celect (38%), Bard (31.4%), Option (26.2%), Tulip (4.1%), and Recovery (0.2%). Bard was more commonly used as a retrievable filter (80.9%). Retrieval on the first attempt was 90.4% (n = 66) successful. Of the remaining seven filters, three were successfully retrieved on a second attempt, and four failed to retrieve due to filter tilt. The success rates of retrieval for Celect and Tulip were significantly lower than for Bard (p = 0.04 and 0.023, respectively). Our study showed that a variety of IVC filters can be retrieved successfully with minimal complication rates. In more than half of our patients, IVC filters were used as permanent. Failure of retrieval was most frequently due to filter tilting. © The Author(s) 2014.

An American Indian Development Finance Institution. A Compendium of Papers Submitted to the Select Committee on Indian Affairs of the United States Senate (April, 1986).

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Select Committee on Indian Affairs.

These papers provide indepth analyses of barriers to and proposals for economic development on Indian reservations. The collection is a follow through to April 29, 1982 hearings of the Select Committee on Indian Affairs of the United States Senate. Alan R. Parker and Charles Trimble survey Indian economic development issues including the federal…

The Research Self-Efficacy of Counselor Education and Supervision Doctoral Students

ERIC Educational Resources Information Center

Jones, Amy L.

2012-01-01

Research self-efficacy refers to a person's confidence in their ability to perform research activities (Bailey, 1999; Bard et al., 2000; Deemer, 2010; Holden et al., 1999; Kahn, 2001; Mulliken et al., 2007; Phillips et al., 2004; Unrau & Beck, 2004, Unrau & Grinnel, 2005). Little has been written on this topic in relation to Counselor…

On the Role of Surface States in Semiconductor Electrode Photoelectrochemical Cells.

DTIC Science & Technology

1980-10-27

D~iscus~sion 70 -70/1I--Bard -7A HARD, FAN, GIODA, NAGASUORAMANIAN, WHITE 013 ’W. E. Spicer, 1. Lindau. P. Skeath, C. Y. Su and P. Chye , Ph vs. Ret...Chemistry Division 715 Broadway Chins Lake, California 93555 New York, New York 10003 Naval Civi1l Engineering Laboratorv ONR Western Regional Office

Organizational Identity in the History of the Longy School of Music

ERIC Educational Resources Information Center

Powell, Alex

2014-01-01

The Longy School of Music existed as an independent organization from 1915 until 2012, when it was acquired by Bard College. Founded to provide vocational training in music, the Longy School soon expanded by adding preparatory studies for children and continuing studies for avocational learners. The school struggled throughout much of its history…

Shakespearean Intertexts and European Identities in Contemporary Black British Fiction

ERIC Educational Resources Information Center

Muñoz-Valdivieso, Sofía

2012-01-01

The article analyses the presence of William Shakespeare as intertext in three recent novels by black British writers which deploy the work of the Bard as they explore British and European identities. Caryl Phillips's "The Nature of Blood" recreates an Othello-like figure who in early Modern Venice struggles to come to terms with his…

A practitioner's tool for assessing glide crack activity

USGS Publications Warehouse

Hendrikx, Jordy; Peitzsch, Erich H.; Fagre, Daniel B.

2010-01-01

Glide cracks can result in full-depth glide avalanche release. Avalanches from glide cracks are notoriously difficult to forecast, but are a reoccurring problem in a number of different avalanche forecasting programs across a range of snow climates. Despite this, there is no consensus for how to best manage, mitigate, or even observe glide cracks and the potential resultant avalanche activity. It is thought that an increase in the rate of snow gliding occurs prior to full-depth avalanche activity, so frequent measuring of glide crack movement provides an index of instability. Therefore, a comprehensive avalanche program with glide crack avalanche activity, should at the least, undertake some form of direct monitoring of glide crack movement. In this paper we present a simple, cheap and repeatable method to track glide crack activity using a series of stakes, reflectors and a laser rangefinder (LaserTech TruPulse360B) linked to a GPS (Trimble Geo XH). We tested the methodology in April 2010, on a glide crack above the Going to the Sun Road in Glacier National Park, Montana, USA. This study suggests a new method to better track the development and movement of glide cracks. It is hoped that by introducing a workable method to easily record glide crack movement, avalanche forecasters will improve their understanding of when, or if, avalanche activity will ensue. Our initial results suggest that these new observations, when combined with local micrometeorological data will result in improved process understanding and forecasting of these phenomena.

Reliability Assessment of the Defense Automated Neurobehavioral Assessment (DANA) in Extreme Environments

DTIC Science & Technology

2015-05-01

multiple automated cognitive tests, data management and reporting capabilities, and executive menu. The DANA battery was given on a Trimble NOMAD ...handheld computing device using a stylus for consistency. The NOMAD runs a custom version of the Android Operating System and has a color 3.5 inch... digit pairs are shown below a key, & the participant indicates it matches the one in the key. PRO This test targets decision-making capabilities

RTX Correction Accuracy and Real-Time Data Processing of the New Integrated SeismoGeodetic System with Real-Time Acceleration and Displacement Measurements for Earthquake Characterization Based on High-Rate Seismic and GPS Data

NASA Astrophysics Data System (ADS)

Zimakov, L. G.; Raczka, J.; Barrientos, S. E.

2016-12-01

We will discuss and show the results obtained from an integrated SeismoGeodetic System, model SG160-09, installed in the Chile (Chilean National Network), Italy (University of Naples Network), and California. The SG160-09 provides the user high rate GNSS and accelerometer data, full epoch-by-epoch measurement integrity and the ability to create combined GNSS and accelerometer high-rate (200Hz) displacement time series in real-time. The SG160-09 combines seismic recording with GNSS geodetic measurement in a single compact, ruggedized case. The system includes a low-power, 220-channel GNSS receiver powered by the latest Trimble-precise Maxwell™6 technology and supports tracking GPS, GLONASS and Galileo signals. The receiver incorporates on-board GNSS point positioning using Real-Time Precise Point Positioning (PPP) technology with satellite clock and orbit corrections delivered over IP networks. The seismic recording includes an ANSS Class A, force balance accelerometer with the latest, low power, 24-bit A/D converter, producing high-resolution seismic data. The SG160-09 processor acquires and packetizes both seismic and geodetic data and transmits it to the central station using an advanced, error-correction protocol providing data integrity between the field and the processing center. The SG160-09 has been installed in three seismic stations in different geographic locations with different Trimble global reference stations coverage The hardware includes the SG160-09 system, external Zephyr Geodetic-2 GNSS antenna, both radio and high-speed Internet communication media. Both acceleration and displacement data was transmitted in real-time to the centralized Data Acquisition Centers for real-time data processing. Command/Control of the field station and real-time GNSS position correction are provided via the Pivot platform. Data from the SG160-09 system was used for seismic event characterization along with data from traditional seismic and geodetic stations installed in the network. Our presentation will focus on the key improvements of the network installation with the SG160-09 system, RTX correction accuracy obtained from Trimble Global RTX tracking network, rapid data transmission, and real-time data processing for strong seismic events and aftershock characterization.

Nanoscale Ionic Liquids

DTIC Science & Technology

2006-11-01

Technical Report 11 December 2005 - 30 November 2006 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Nanoscale Ionic Liquids 5b. GRANT NUMBER FA9550-06-1-0012...Title: Nanoscale Ionic Liquids Principal Investigator: Emmanuel P. Giannelis Address: Materials Science and Engineering, Bard Hall, Cornell University...based fluids exhibit high ionic conductivity. The NFs are typically synthesized by grafting a charged, oligomeric corona onto the nanoparticle cores

Wood and Bark Properties of Spruce Pine

Treesearch

F. G. Manwiller

1972-01-01

Weighted stem averagees were determined for wood and bard of 72 trees representing the commercial range of Pinus glabra Walt. The trees were stratified into three age classes (15, 30, and 45 years) and two growth rates (averaging 4.9 and 9.0 rings per inch). Within-stem variation was determined from 1,269 earlywood and alte wood sampling points in...

Coordination of BRCA1/BARD1- and MRE11/RAD50/NBS1-dependent DNA Transactions in Breast Tumor Suppression

DTIC Science & Technology

2011-07-01

prevent toxic chromosome rearrangements. Because MMEJ is active throughout the cell cycle, it could pro- mote translocations when any of the following...in preserving genomic stability. Genes Dev. 24:1680–94 66. Keelagher RE, Cotton VE, Goldman AS, Borts RH. 2011. Separable roles for exonuclease I in

Coordination of BRCA1/BARD1- and MRE11/RAD50/NBS1-Dependent DNA Transactions in Breast Tumor Suppression

DTIC Science & Technology

2011-07-01

active throughout the cell cycle, it could pro- mote translocations when any of the following aberrancies occur: (a) inhibition of C-NHEJ; (b...in preserving genomic stability. Genes Dev. 24:1680–94 66. Keelagher RE, Cotton VE, Goldman AS, Borts RH. 2011. Separable roles for exonuclease I in

Southeast Asia Report.

DTIC Science & Technology

1985-08-30

orangutans in Beijing zoo have tuberculosis after being bom- barded with rubbish, fruit peelings and spittle by visitors, an official news- paper reported...CHINA YOUTH NEWS said... One orangutan ’counterattacked’ by throwing stones at its tormenters—and the paper applauded the animal for getting its...revenge." If the orangutan deserves to be applauded for retaliating against those that bombarded it with rubbish, surely my advocacy that PAP MPs be

A Milestone in Cancer Research and Treatment in India

Cancer.gov

Tata Memorial Center is celebrating 75 years of leadership service towards cancer control and research in India. In honor of this anniversary, TMC is hosting A Conference of New Ideas in Cancer – Challenging Dogmas on February 26-28th, 2016 as part of its platinum jubilee events. CGH Director, Dr. Ted Trimble, will give a plenary talk: "Thinking Outside the Box in Cancer Research - Perspectives from the US NCI” in the session titled: Future of Cancer Research: US and European perspectives.

Objectification of Public Bus Stop's Pavement Surface Morphology

NASA Astrophysics Data System (ADS)

Decký, Martin; Kováč, Matúš; Mužík, Juraj; Mičechová, Lenka; Ďuriš, Lukáš

2018-06-01

The article deals with the road pavement surface morphology objectification in term of the surface unevenness degradation during the life cycle of bus stop pavements. The article presents the results of long-term rut depth measurements performed during 25 years on selected bus stops which were intended to determine correlation dependences of pavement rut depth on a number of design axles. The article also presents different methods for rut depth measurements including the straightedge test, Profilograph GE, TRIMBLE CX, and dynamic Road Scanner.

Status of the Bureau of Indian Affairs Reorganization. Hearing Before the United States Senate Select Committee on Indian Affairs, 95th Congress, 2nd Session on Oversight on the Status of the Reorganization of the Bureau of Indian Affairs.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Select Committee on Indian Affairs.

The objective of the August 16, 1978, United States Senate hearing was to determine reorganization plans for the Bureau of Indian Affairs (BIA). The Assistant Secretary of the Interior for Indian Affairs, two Deputy Secretaries, and Mr. Charles Trimble of the United Effort Trust testified before the Select Committee on Indian Affairs. The…

The New Wizard War: Challenges and Opportunities for Electronic Warfare in the Information Age

DTIC Science & Technology

2007-11-06

Camp: Preparing for Conflict in the Information Age (Santa Monica, CA: RAND Corporation, 1997):175. 17. Jeffrey R . Cares, “An Information Age Combat...60. Stephen Trimble, “US Army Moves Back Into Electronic Attack Mission.” 61. Richard R . Burgess, “Jamming: The Marine Corps Refines Its Vision of...November 7, 2005), http://www.aviationweek.com/aw/generic/story_generic.jsp?channel= awst &id=news/11075p 2.xml (accessed 29 Oct 07). 74. David A

Demonstration of Advanced Geophysics and Classification Methods on Munitions Response Sites: Closed Castner Range Fort Bliss, TX

DTIC Science & Technology

2016-04-01

Program ft foot/feet GPS Global Positioning System HE High Explosive ID Identification IDA Institute for Defense Analysis IMU Inertial Measurement Unit ISO...were replaced with two ski-shaped runners, and a new mount above the array was used to hold the Inertial Measurement Unit (IMU) and Trimble R8 Real...to collect a cued data measurement (Figure 9). The instrument’s pitch, roll , and yaw angles automatically were measured by the IMU. These angles and

DoD Metric Seminar/Workshop (1980) Held in Washington, DC 18-20 November 1980.

DTIC Science & Technology

1981-04-23

SECTION OF THE FEDERAL REGISTER IN FINAL FORM ON SEPTEMBER 16, 1980. ADDITIONALLY, THE BOARD HAS IN COOPERATION WITH THE DEPARTMENT OF JUSTICE AND THE...TRLMBLE Mr. Trimble was born in Alabama and reared in Virginia. He graduated from the United States Military Academy in 1945 with a Bachelor of Science...BF685A, The Pentagon Washington, DC 20301 202-695-9996 AV 225-9996 119. Wilton McIntosh Bureau of Medicine and Surgery Department of the Navy Washington

Effects of Locomotion Over Varied Terrain on Soldier Vigilance

DTIC Science & Technology

2008-12-01

control in neurologically intact adults. However, a growing body of research demonstrates that attention is required when moving over difficult...results are discussed relative to challenges dismounted warfighters face in maintaining situation awareness during movement over rugged terrain. 1...Bard, and Fleury 1996). This makes sense given that one leg must supp0l1 the body while the swinging leg generates torques that must be counteracted

Using Internet-Based Automated Software to Process GPS Data at Michigan Tech University

NASA Astrophysics Data System (ADS)

Crook, A.; Diehl, J. F.

2003-12-01

The Michigan Tech University GPS monument was made operational in October of 2002. The monument, which consists of a concrete pillar extending approximately 10 feet below the surface and protrudes 5 feet above ground, is located at the Houghton County Memorial Airport (47.171803° N, 88.498361° W). The primary purpose of the monument is to measure the velocity of the North American Plate at this location. A Trimble 4000ssi geodetic receiver with a Trimble Zephyr antenna is used to collect GPS data. The data are sent to a PC where they are processed using Auto-GIPSY, an internet-based GPS processing utility, which makes it possible to process GPS data, via email, without having knowledge of how the software works. Two Perl scripts were written to facilitate automation and to simplify processing of the GPS data even further. Twelve months of GPS data were processed, using Auto-GIPSY, which produced a velocity of -24 +/- 5 mm/yr and -4 +/- 6 mm/yr for the X and Y components respectively with an azimuth of 261° with respect to the ITRF2000. This calculated result compares well with the NNR-NUVEL1A velocity of -17 mm/yr and -1 mm/yr for the X and Y components respectively with an azimuth of 267° . The results from an alternative online processing service, the Scripps Coordinate Update Tool (SCOUT) that uses GAMIT, will also be presented as a comparative method.

Technique for Rearing Mite-Free Southern Pine Beetle, Dendroctonus frontalis Zimmermann (Coleoptera: Scolytidae), Adults

Treesearch

John C. Moser; J. Robert Bridges

1983-01-01

Southern pine beetles can be reared free of phoretic mites from naturally infested bark if the bark is removed from the tree and air dried. Bark removal does not reduce the number of beetles that emerge. On the average fewer than 1% of the beetles emerging from removed bark carried one or fewer mites, and 85% of the beetles emerging from attacked bard carried one or...

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

PubMed Central

Ramus, Susan J.; Song, Honglin; Dicks, Ed; Tyrer, Jonathan P.; Rosenthal, Adam N.; Intermaggio, Maria P.; Fraser, Lindsay; Gentry-Maharaj, Aleksandra; Hayward, Jane; Philpott, Susan; Anderson, Christopher; Edlund, Christopher K.; Conti, David; Harrington, Patricia; Barrowdale, Daniel; Bowtell, David D.; Alsop, Kathryn; Mitchell, Gillian; Cicek, Mine S.; Cunningham, Julie M.; Fridley, Brooke L.; Alsop, Jennifer; Jimenez-Linan, Mercedes; Poblete, Samantha; Lele, Shashi; Sucheston-Campbell, Lara; Moysich, Kirsten B.; Sieh, Weiva; McGuire, Valerie; Lester, Jenny; Bogdanova, Natalia; Dürst, Matthias; Hillemanns, Peter; Odunsi, Kunle; Whittemore, Alice S.; Karlan, Beth Y; Dörk, Thilo; Goode, Ellen L.; Menon, Usha; Jacobs, Ian J.; Antoniou, Antonis C.; Pharoah, Paul D. P.; Gayther, Simon A.

2015-01-01

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based on identifying germline mutations in ovarian cancer susceptibility genes could have a clinically significant impact on reducing disease mortality. Methods: Next generation sequencing was used to identify germline mutations in the coding regions of four candidate susceptibility genes—BRIP1, BARD1, PALB2 and NBN—in 3236 invasive EOC case patients and 3431 control patients of European origin, and in 2000 unaffected high-risk women from a clinical screening trial of ovarian cancer (UKFOCSS). For each gene, we estimated the prevalence and EOC risks and evaluated associations between germline variant status and clinical and epidemiological risk factor information. All statistical tests were two-sided. Results: We found an increased frequency of deleterious mutations in BRIP1 in case patients (0.9%) and in the UKFOCSS participants (0.6%) compared with control patients (0.09%) (P = 1 x 10–4 and 8 x 10–4, respectively), but no differences for BARD1 (P = .39), NBN1 (P = .61), or PALB2 (P = .08). There was also a difference in the frequency of rare missense variants in BRIP1 between case patients and control patients (P = 5.5 x 10–4). The relative risks associated with BRIP1 mutations were 11.22 for invasive EOC (95% confidence interval [CI] = 3.22 to 34.10, P = 1 x 10–4) and 14.09 for high-grade serous disease (95% CI = 4.04 to 45.02, P = 2 x 10–5). Segregation analysis in families estimated the average relative risks in BRIP1 mutation carriers compared with the general population to be 3.41 (95% CI = 2.12 to 5.54, P = 7×10–7). Conclusions: Deleterious germline mutations in BRIP1 are associated with a moderate increase in EOC risk. These data have clinical implications for risk prediction and prevention approaches for ovarian cancer and emphasize the critical need for risk estimates based on very large sample sizes before genes of moderate penetrance have clinical utility in cancer prevention. PMID:26315354

Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis.

PubMed

Xiao, Guangqin; Zhu, Sixian; Xiao, Xiao; Yan, Lunan; Yang, Jiayin; Wu, Gang

2017-11-01

Many noninvasive methods for diagnosing liver fibrosis (LF) have been proposed. To determine the best method for diagnosing LF in nonalcoholic fatty liver disease (NAFLD), we conducted a systemic review and meta-analysis to compare the performance of aspartate aminotransferase to platelets ratio index (APRI), fibrosis-4 index (FIB-4), BARD score, NAFLD fibrosis score (NFS), FibroScan, shear wave elastography (SWE), and magnetic resonance elastography (MRE) for diagnosing LF in NAFLD. We compared the sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve (AUROC) of these noninvasive methods for detecting significant fibrosis (SF), advanced fibrosis (AF), and cirrhosis. Heterogeneity was explored using meta-regression. Sixty-four articles with a total of 13,046 NAFLD subjects were included. The overall mean prevalence of SF, AF, and cirrhosis was 45.0%, 24.0%, and 9.4% in NAFLD patients, respectively. With an APRI threshold of 1.0 and 1.5, the sensitivities and specificities were 50.0% and 84.0% and 18.3% and 96.1%, respectively, for AF. With a FIB-4 threshold of 2.67 and 3.25, the sensitivities and specificities were 26.6% and 96.5% and 31.8% and 96.0%, respectively, for AF. The summary sensitivities and specificities of BARD score (threshold of 2), NFS (threshold of -1.455), FibroScan M (threshold of 8.7-9), SWE, and MRE for detecting AF were 0.76 and 0.61, 0.72 and 0.70, 0.87 and 0.79, 0.90 and 0.93, and 0.84 and 0.90, respectively. The summary AUROC values using APRI, FIB-4, BARD score, NFS, FibroScan M probe, XL probe, SWE, and MRE for diagnosing AF were 0.77, 0.84, 0.76, 0.84, 0.88, 0.85, 0.95, and 0.96, respectively. MRE and SWE may have the highest diagnostic accuracy for staging fibrosis in NAFLD patients. Among the four noninvasive simple indexes, NFS and FIB-4 probably offer the best diagnostic performance for detecting AF. (Hepatology 2017;66:1486-1501). © 2017 by the American Association for the Study of Liver Diseases.

The Role of BRCA1/BARD1 Heterodimers in the Mitosis-Interphase Transition

DTIC Science & Technology

2007-05-01

53 4 INTRODUCTION Germ line mutations in the BRCA1 gene predispose to breast and/or ovarian cancer (Miki, et al...Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53...Ludwig, T., Chapman, D.L., Papaioannou, V.E., and Efstratiadis, A. (1997). Targeted mutations of breast cancer susceptibility gene homo- logs in mice

Photoelectrosynthesis and Photocatalysis at Semiconductor Electrodes.

DTIC Science & Technology

1981-08-01

AO-AS10 136 TEXAS UNIV AT AUSTIN DEPT OF CHEMISTRY F/6 20/12 PI4OTOELECTROSYNTHESIS AND PHOTOCATALYSIS AT SEMICODUCTOR ELECT--ETC(U) AUG 81 A J BARD...RESEARCH Contract N00014-78-C-0592 Task No. NR 051-693 * TECHNICAL REPORT No. 18 PHOTOELECTROSYNTHESIS AND PHOTOCATALYSIS AT SEMICONDUCTOR ELECTRODES...A 1C 4. TITLE (and Subtitle) 0 S. TYPE OF REPORT A PERIOD COVERED Photoelectrosynethesis and Photocatalysis 9/1/80-8/31/81 at Semiconductor

Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.

PubMed

Takagi, Toshinori; Kitashoji, Akira; Iwawaki, Takao; Tsuruma, Kazuhiro; Shimazawa, Masamitsu; Yoshimura, Shinichi; Iwama, Toru; Hara, Hideaki

2014-07-01

Oxidative stress plays a critical role in mediating tissue injury and neuron death during ischemia-reperfusion injury (IRI). The Keap1-Nrf2 defense pathway serves as a master regulator of endogenous antioxidant defense, and Nrf2 has been attracting attention as a target for the treatment of IRI. In this study, we evaluated Nrf2 expression in IRI using OKD (Keap1-dependent oxidative stress detector) mice and investigated the neuroprotective ability of an Nrf2 activator. We demonstrated temporal changes in Nrf2 expression in the same mice with luciferase assays and an Nrf2 activity time course using Western blotting. We also visualized Nrf2 expression in the ischemic penumbra and investigated Nrf2 expression in mice and humans using immunohistochemistry. Endogenous Nrf2 upregulation was not detected early in IRI, but expression peaked 24h after ischemia. Nrf2 expression was mainly detected in the penumbra, and it was found in neurons and astrocytes in both mice and humans. Intravenous administration of the Nrf2 activator bardoxolone methyl (BARD) resulted in earlier upregulation of Nrf2 and heme oxygenase-1. Furthermore, BARD decreased infarction volume and improved neurological symptoms after IRI. These findings indicate that earlier Nrf2 activation protects neurons, possibly via effects on astrocytes. Copyright © 2014 Elsevier Inc. All rights reserved.

From Ξb→Λbπ to Ξc→Λcπ

DOE PAGES

Gronau, Michael; Rosner, Jonathan L.

2016-04-11

Using a successful framework for describing S-wave hadronic decays of light hyperons induced by a subprocess s -> u((u) over bard), we presented recently a model-independent calculation of the amplitude and branching ratio for Xi(-)(b) -> Lambda(b)pi(-) in agreement with a LHCb measurement. The same quark process contributes to Xi(0)(c) -> Lambda(c)pi(-), while a second term from the subprocess cs -> cd has been related by Voloshin to differences among total decay rates of charmed baryons. We calculate this term and find it to have a magnitude approximately equal to the s -> u((u) over bard) term. We argue formore » a negligible relative phase between these two contributions, potentially due to final state interactions. However, we do not know whether they interfere destructively or constructively. For constructive interference one predicts B(Xi(0)(c) -> Lambda(c)pi(-)) = (1.94 +/- 0.70) x 10(-3) and B(Xi(+)(c) -> Lambda(c)pi(0)) = (3.86 +/- 1.35) x 10(-3). For destructive interference, the respective branching fractions are expected to be less than about 10(-4) and 2 x 10(-4). (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP(3).« less

From Ξb→Λbπ to Ξc→Λcπ

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gronau, Michael; Rosner, Jonathan L.

Using a successful framework for describing S-wave hadronic decays of light hyperons induced by a subprocess s -> u((u) over bard), we presented recently a model-independent calculation of the amplitude and branching ratio for Xi(-)(b) -> Lambda(b)pi(-) in agreement with a LHCb measurement. The same quark process contributes to Xi(0)(c) -> Lambda(c)pi(-), while a second term from the subprocess cs -> cd has been related by Voloshin to differences among total decay rates of charmed baryons. We calculate this term and find it to have a magnitude approximately equal to the s -> u((u) over bard) term. We argue formore » a negligible relative phase between these two contributions, potentially due to final state interactions. However, we do not know whether they interfere destructively or constructively. For constructive interference one predicts B(Xi(0)(c) -> Lambda(c)pi(-)) = (1.94 +/- 0.70) x 10(-3) and B(Xi(+)(c) -> Lambda(c)pi(0)) = (3.86 +/- 1.35) x 10(-3). For destructive interference, the respective branching fractions are expected to be less than about 10(-4) and 2 x 10(-4). (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP(3).« less

Maintenance Enterprise Resource Planning: Information Value Among Supply Chain Elements

DTIC Science & Technology

2014-12-01

to$Normal$Science$ Textbook,$ar8cles$ Journal,$Socie8es$ Profession$ New$Disciplines$ New$School$ $ Material$ Managemen t $ Pr e+ Pa ra di gm :$ Th ou...Jensen, P., & Bard, J. F. (2002). Operations research models and methods (1st ed., p. 700). Danvers, MA: Wiley. Jitpaiboon, T . (2005). The roles of...of Operations Research, 19(3), 337–357. doi:10.1007/s10100-010-0168-1 Kuhn, T . S. (1970). The structure of scientific revolutions (2nd ed.). Chicago

A Market Analysis of Publications, Trade Conferences, and Key Events for Fleet Readiness Center Southwest

DTIC Science & Technology

2007-12-01

Win and Keep Big Customers. Austin: Bard Press, 2005. Kotler , Philip and Kevin Lane Keller. Marketing Management. Upper Saddle River, NJ...stimulate awareness and demand with little or no cost. Kotler and Keller describe public relations and publicity as “a variety of programs designed to...broadcast media to promote something.”13 Kotler and Keller also argue that there is an appeal to the use of public relations and publicity that is based

The Future Today: Creating an All Purpose Battalion to Enhance the Marine Corps’ Capabilities for Tomorrow, Today

DTIC Science & Technology

2008-01-01

Maude, (Houghton Mifflin, Boston MA, and New York, NY, 1920), p. 279. 21Author’s notes from personal interview. . 22Philip Kotler , Marketing Management...Hoffman, Frank G. "Conflict in the 21st Century: The rise of Hybrid Wars.", Arlington, VA: Potomac Institute for Policy Studies (2007) p. 26. . Kotler ... Philip . Marketing Management 11th Ed. Upper Saddle River, NJ: Pearson Education LTD., 2003. 24 Oneill, Bard E. Insurgency and Terrorism. Washington, D.C

Electrochemistry in Near-Critical and Supercritical Fluids. 4. Nitrogen Heterocycles, Nitrobenzene, and Solvated Electrons in Ammonia at Temperatures to 150C.

DTIC Science & Technology

1986-09-01

of pyraz ne quinoxaline, phenazine and solvated electrons in near-critical and supercritical ammonia was investigated by cycU-i Voltanimetry and...Crooks and Allen J. Bard Department of Chemistry, University of Texas Austin, Texas 78712 ABSTRACT The electrochemistry of pyrazine, quinoxaline, phenazine ...in liquid ammonia at -40° C. The reductions of pyrazine, quinoxaline and phenazine at room temperature, and in the supercritical fluid (SCF), occur

The Fanconi Anemia BRCA Pathway as a Predictor of Benefit from Bevacizumab in a Large Phase-3 Clinical Trial in Ovarian Cancer

DTIC Science & Technology

2014-10-01

FAM175A (3), PMS2 (2), and MLH1 (1). Consistent with their role as ovarian cancer susceptibility genes, BRIP1, RAD51C, and RAD51D were significantly...ATM (11), RAD51C (10), NBN (9), TP53 (6), BARD1 (4), MSH6 (4), FAM175A (3), PMS2 (2), and MLH1 (1). Consistent with their role as ovarian cancer

Sierra Club, Save the Valley, and Valley Watch Petition to Object to Louisville Gas and Electric Trimble Power Station Title V Permit

EPA Pesticide Factsheets

This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum follow-up of 180 days.

PubMed

Biffi, R; de Braud, F; Orsi, F; Pozzi, S; Mauri, S; Goldhirsch, A; Nolè, F; Andreoni, B

1998-07-01

A few data are available from analyses of the complications and costs of central venous access ports for chemotherapy. This prospective study deals with the complications and global costs of central venous ports connected to a Groshong catheter for deliverance of long-term chemotherapy. Patients with a variety of solid neoplastic diseases requiring chemotherapy who were undergoing placement of implantable ports over a 30-month period (1 October 1994 to 31 March 1997) have been prospectively studied. Follow-up continued until the device was removed or the study was closed (30 September 1997); patients with uneventful implant experience and subsequent follow-ups of less than 180 days were not considered for this study. A single port, constructed of titanium and silicone rubber (Dome Port, Bard Inc., Salt Lake City, USA), was used, connected to an 8 F silastic Groshong catheter tubing (Bard Inc., Salt Lake City, USA). Two-hundred ninety-six devices were placed in the operating room under fluoroscopic control even in the patients treated and monitored in a day-hospital setting: 37 of them were in an angiographic suite. A central venous access form was filled in by the operator after the procedure and all ports were followed prospectively for device-related and overall complications. The average purchase cost of the device was obtained from the hospital charges, based on the costs applied during the 30-month period of the study. Insertion and maintenance costs were estimated by obtaining the charges for an average TIAP implant and its subsequent use; the costs of complication management were assessed analytically. The total cost of each device was defined as the purchase cost plus the insertion cost plus the maintenance cost plus the cost of treatment of the complications, if any. The cost of removing the TIAP was also included in the economic analysis when required by the treatment of the complication. Three hundred thirty-three devices, for a total of 79,178 days in situ, were placed in 328 patients. Five patients received second devices after removal of the first. In all cases the follow-up was appropriate (median 237 days, range 180-732). Early complications included 10 pneumothoraxes (3.4%; six tube-thoracostomies were applied, 1.8%) and six revisions for port and/or catheter malfunction (overall early complications = 16, 4.48%). Late complications comprised five instances of catheter rupture and embolization (1.5%, 0.063 episodes/1000 days of use), five of venous thrombosis (1.5%, 0.063 episodes/1000 days of use), one of pocket infection (0.3%, 0.012 episodes/1000 days of use), and eight of port-related bacteremia (2.4%, 0.101 episodes/1000 days of use). The infections were caused by coagulase-negative Staphylococcus aureus (five cases), Bacillus subtilis (one case), Streptococcus lactaceae (one case) and an unknown agent (one case); port removal was necessary in six of eight cases. The total cost per patient treated for a six-month period, consisting of the costs of purchase and implantation, treatment of early and late complications, and of maintenance of the device, is US$1,970. This study represents the largest published series of patients with totally implantable access ports connected to a Groshong catheter. We have shown that US$2,000 are sufficient to cover six months of chemotherapy in one patient using the most expensive commercially available implantable port. According to the present study, totally implantable access ports connected to a Groshong catheter are associated with high purchase and insertion costs, a low complication rate and low maintenance costs. These data support their increasing use in current oncologic medical practice.

Microstructural Characterization of a Directionally-Solidified Ni-33 (at. %)Al-31Cr-3Mo Eutectic Alloy as a Function of Withdrawal Rate

NASA Technical Reports Server (NTRS)

Raj, S. V.; Locci, I. E.; Whittenberger, J. D.; Salem, J. A.

2000-01-01

The Ni-33 (at. %)Al-3lCr-3Mo eutectic alloy was directionally-solidified (DS) at different rates, V(sub I), varying between 2.5 to 508 mm/ h. Detailed qualitative and quantitative metallographic and chemical analyses were conducted on the directionally-solidified rods. The microstructures consisted of eutectic colonies with parallel lamellar NiAl/(Cr,Mo) plates for solidification rates at and below 12.7 mm/ h. Cellular eutectic microstructures were observed at higher solidification rates, where the plates exhibited a radial pattern. The microstructures were demonstrated to be fairly uniform throughout a 100 mm length of the DS zone by quantitative metallography. The average cell size, bar-d, decreased with increasing growth rate to a value of 125 microns at 508 mm/ h according to the relation bar-d (microns) approx. = 465 V(sup -0.22, sub I), where V(sub I) is in mm/ h. Both the average NiAl plate thickness, bar-Delta(sub NiAl), and the interlamellar spacing, bar-lambda, were observed to be constant for V(sub I) less than or = 50.8 mm/ h but decreased with increasing growth rate above this value as 0.93 bar-Delta(sub NiAl)(microns) = 61.2 V(sup -0.93, sub I) and bar-lambda (microns) = 47.7 V(sup -0.64, sub I), respectively. The present results are detailed on a microstructural map. Keywords Optical microscopy, microstructure, compounds intermetallic, directional solidification

Retrieval characteristics of the Bard Denali and Argon Option inferior vena cava filters.

PubMed

Dowell, Joshua D; Semaan, Dominic; Makary, Mina S; Ryu, John; Khayat, Mamdouh; Pan, Xueliang

2017-11-01

The purpose of this study was to compare the retrieval characteristics of the Option Elite (Argon Medical, Plano, Tex) and Denali (Bard, Tempe, Ariz) retrievable inferior vena cava filters (IVCFs), two filters that share a similar conical design. A single-center, retrospective study reviewed all Option and Denali IVCF removals during a 36-month period. Attempted retrievals were classified as advanced if the routine "snare and sheath" technique was initially unsuccessful despite multiple attempts or an alternative endovascular maneuver or access site was used. Patient and filter characteristics were documented. In our study, 63 Option and 45 Denali IVCFs were retrieved, with an average dwell time of 128.73 and 99.3 days, respectively. Significantly higher median fluoroscopy times were experienced in retrieving the Option filter compared with the Denali filter (12.18 vs 6.85 minutes; P = .046). Use of adjunctive techniques was also higher in comparing the Option filter with the Denali filter (19.0% vs 8.7%; P = .079). No significant difference was noted between these groups in regard to gender, age, or history of malignant disease. Option IVCF retrieval procedures required significantly longer retrieval fluoroscopy time compared with Denali IVCFs. Although procedure time was not analyzed in this study, as a surrogate, the increased fluoroscopy time may also have an impact on procedural direct costs and throughput. Copyright © 2017 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Evaluation of Electromagnetic Induction to Characterize and Map Sodium-Affected Soils in the Northern Great Plains of the United States

NASA Astrophysics Data System (ADS)

Brevik, E. C.; Heilig, J.; Kempenich, J.; Doolittle, J.; Ulmer, M.

2012-04-01

Sodium-affected soils (SAS) cover over 4 million hectares in the Northern Great Plains of the United States. Improving the classification, interpretation, and mapping of SAS is a major goal of the United States Department of Agriculture-Natural Resource Conservation Service (USDA-NRCS) as Northern Great Plains soil surveys are updated. Apparent electrical conductivity (ECa) as measured with ground conductivity meters has shown promise for mapping SAS, however, this use of this geophysical tool needs additional evaluation. This study used an EM-38 MK2-2 meter (Geonics Limited, Mississauga, Ontario), a Trimble AgGPS 114 L-band DGPS (Trimble, Sunnyvale, CA) and the RTmap38MK2 program (Geomar Software, Inc., Mississauga, Ontario) on an Allegro CX field computer (Juniper Systems, North Logan, UT) to collect, observe, and interpret ECa data in the field. The ECa map generated on-site was then used to guide collection of soil samples for soil characterization and to evaluate the influence of soil properties in SAS on ECa as measured with the EM-38MK2-2. Stochastic models contained in the ESAP software package were used to estimate the SAR and salinity levels from the measured ECa data in 30 cm depth intervals to a depth of 90 cm and for the bulk soil (0 to 90 cm). This technique showed promise, with meaningful spatial patterns apparent in the ECa data. However, many of the stochastic models used for salinity and SAR for individual depth intervals and for the bulk soil had low R-squared values. At both sites, significant variability in soil clay and water contents along with a small number of soil samples taken to calibrate the ECa values to soil properties likely contributed to these low R-squared values.

The Leadership Development of Dwight D. Eisenhower and George S. Patton Jr

DTIC Science & Technology

2009-06-12

received a telegram from Senator Bard, informing him of Patton‘s selection for West Point. 35 Patton‘s dream of attending West Point finally emerged...foolish dream --it is me as I ever will be. I am different from other men my age. All they want to do is to live happily and die old. I would be...to the future asking himself how he could gain the fame he had looked for. He determined that his dream could not come true if America remained at

Squeezed Back-to-Back Correlation of {D}^{0}{\\bar{D}}^{0} in Relativistic Heavy-Ion Collisions

NASA Astrophysics Data System (ADS)

Yang, Ai-Geng; Zhang, Yong; Cheng, Luan; Sun, Hao; Zhang, Wei-Ning

2018-05-01

We investigate the squeezed back-to-back correlation (BBC) of $D^0\\!{\\bar D}^0$ in relativistic heavy-ion collisions, using the in-medium mass modification calculated with a self-energy in hot pion gas and the source space-time distributions provided by the viscous hydrodynamic code VISH2+1. It is found that the BBC of $D^0\\!{\\bar D}^0$ is significant in peripheral Au+Au collisions at the RHIC energy. A possible way to detect the BBC in experiment is presented.

Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer

ClinicalTrials.gov

2018-05-31

ATM Gene Mutation; ATR Gene Mutation; BARD1 Gene Mutation; BRCA1 Gene Mutation; BRCA2 Gene Mutation; BRIP1 Gene Mutation; CHEK1 Gene Mutation; CHEK2 Gene Mutation; FANCA Gene Mutation; FANCC Gene Mutation; FANCD2 Gene Mutation; FANCF Gene Mutation; FANCM Gene Mutation; NBN Gene Mutation; PALB2 Gene Mutation; RAD51 Gene Mutation; RAD51B Gene Mutation; RAD54L Gene Mutation; Recurrent Squamous Cell Lung Carcinoma; RPA1 Gene Mutation; Stage IV Squamous Cell Lung Carcinoma AJCC v7

A Proteomic Approach to Identify Phosphorylation-Dependent Targets of BRCT Domains

DTIC Science & Technology

2008-03-01

5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Zhou Songyang, Ph.D. 5d. PROJECT NUMBER 5e. TASK NUMBER E -Mail: songyang@bcm.tmc.edu 5f...L pSQEY BARD1 SG K H M I pSEDE? ECT2 TG K E R W ? PTIP (560-757) TG K P L L pSQVF pSQEY? TOPBP1...22-207) TS K L L F ? TOPBP1 (1177- 1401) SS K E L A ? XRCC1 SG K E S Y ? BRCTD1 TG K K

Identification of Variants in Breast Cancer Susceptibility Genes and Determination of Functional and Clinical Significance of Novel Mutations

DTIC Science & Technology

2014-10-01

to cause other cancer susceptibility (CDKN2A, MLH1, MSH2, MSH6, PMS2 ); 3) genes known or postulated to be moderate penetrance cancer susceptibility...susceptibility (CDKN2A, MLH1, MSH2, MSH6, PMS2 ); 3) genes known or postulated to be moderate penetrance cancer susceptibility genes (ATM, BARD1, BRIP1...AK, Lindor NM, Jenkins MA. Risk of breast cancer in Lynch syndrome : a systematic review. Breast Cancer Res 2013;15:R27. 55. Brunet J, Gutierrez

100 years of elementary particles [Beam Line, vol. 27, issue 1, Spring 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pais, Abraham; Weinberg, Steven; Quigg, Chris

1997-04-01

This issue of Beam Line commemorates the 100th anniversary of the April 30, 1897 report of the discovery of the electron by J.J. Thomson and the ensuing discovery of other subatomic particles. In the first three articles, theorists Abraham Pais, Steven Weinberg, and Chris Quigg provide their perspectives on the discoveries of elementary particles as well as the implications and future directions resulting from these discoveries. In the following three articles, Michael Riordan, Wolfgang Panofsky, and Virginia Trimble apply our knowledge about elementary particles to high-energy research, electronics technology, and understanding the origin and evolution of our Universe.

100 years of Elementary Particles [Beam Line, vol. 27, issue 1, Spring 1997

DOE R&D Accomplishments Database

Pais, Abraham; Weinberg, Steven; Quigg, Chris; Riordan, Michael; Panofsky, Wolfgang K. H.; Trimble, Virginia

1997-04-01

This issue of Beam Line commemorates the 100th anniversary of the April 30, 1897 report of the discovery of the electron by J.J. Thomson and the ensuing discovery of other subatomic particles. In the first three articles, theorists Abraham Pais, Steven Weinberg, and Chris Quigg provide their perspectives on the discoveries of elementary particles as well as the implications and future directions resulting from these discoveries. In the following three articles, Michael Riordan, Wolfgang Panofsky, and Virginia Trimble apply our knowledge about elementary particles to high-energy research, electronics technology, and understanding the origin and evolution of our Universe.

The CEO's role in business model reinvention.

PubMed

Govindarajan, Vijay; Trimble, Chris

2011-01-01

Fending off new competitors is a perennial struggle for established companies. Govindarajan and Trimble, of Dartmouth's Tuck School of Business, explain why: Many corporations become too comfortable with their existing business models and neglect the necessary work of radically reinventing them. The authors map out an alternative in their "three boxes" framework. They argue that while a CEO manages the present (box 1), he or she must also selectively forget the past (box 2) in order to create the future (box 3). Infosys chairman N.R. Narayana Murthy mastered the three boxes to reinvigorate his company and greatly increased its changes of enduring for generations.

First Apollo 11 sample return containers arrive at Ellington AFB

NASA Technical Reports Server (NTRS)

1969-01-01

The first Apollo 11 sample return container, containing lunar surface material, arrives at Ellington Air Force Base by air from the Pacific recovery area. Happily posing for photographs with the rock box are (left to right) George M. Low, Manager, Apollo Spacecraft Program, Manned Spacecraft Center (MSC); U.S. Air Force Lt. Gen. Samuel C. Phillips, Apollo Program Director, Office of Manned Space Flight, NASA HQ.; George S. Trimble, MSC Deputy Director (almost obscured); Eugene G. Edmonds, MSC Photographic Technology Laboratory; RIchard S. Johnston (in back), Special Assistant to the MSC Director; Dr. Thomas O. Paine, NASA Administrator; and Dr. Robert R. Gilruth, MSC Director.

Treatment of benign biliary leaks with transhepatic placement of coated self-expanding metallic stents.

PubMed

Páramo, M; García-Barquín, P; Carrillo, M; Millor Muruzábal, M; Vivas, I; Bilbao, J I

To analyze the safety and efficacy of percutaneous placement of coated self-expanding metallic stents (SEMS) in patients with biliary leaks. This ethics committee at our center approved this study. We retrospectively reviewed all coated SEMS placed between October 2008 and September 2015. We analyzed patient-related factors such as the primary underlying disease, prior hepatic procedures, and clinical outcome. We evaluated the location, the number and type of leak (anastomotic or non-anastomotic), and the characteristics of the interventional procedure (number of stents deployed, location of the stents, technical success, and primary functionality). We recorded the complications registered. We studied 14 patients (11 men and 3 women). The mean follow-up period was 375.5 days (range 15-1920 days). Leaks were postsurgical in 12 patients. One patient developed an arteriobilioportal fistula. In another, the biliary leak occurred secondary to the rupture of the common bile duct after ERCP. A total of 23 coated SEMS were placed, including 21 Fluency ® stents (Bard, Tempe, AZ, USA) and 2 Wallflex ® stents (Boston Scientific, Galway, Republic of Ireland). The technical success of the procedure was considered total in 11 (78.6%) patients, partial in 2 (14.3%) patients, and null in 1 (7.2%) patient. The clinical outcome was good in 13 of the 14 patients. The mean period of primary functionality of the coated SEMS was 331 days (range 15-1920 days). No major complications were observed in 11 (78.6%) patients. Percutaneous placement of coated SEMS for the treatment of benign biliary leaks is safe and efficacious, with a high rate of technical and clinical success and a moderate rate of complications. Copyright © 2016 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

Contactless, probeless and non-titrimetric determination of acid-base reactions using broadband acoustic resonance dissolution spectroscopy (BARDS).

PubMed

Ahmed, M Rizwan; McSweeney, Sean; Krüse, Jacob; Vos, Bastiaan; Fitzpatrick, Dara

2018-02-12

pH determination is a routine measurement in scientific laboratories worldwide. Most major advances in pH measurement were made in the 19th and early 20th century. pH measurements are critical for the determination of acid base reactions. This study demonstrates how an acid-base reaction can be monitored without the use of a pH probe, indicator and titres of reagent. The stoichiometric reaction between carbonate and HCl acid yields specific quantities of CO 2 , which causes reproducible changes to the compressibility of the solvent. This in turn slows down the speed of sound in solution which is induced by a magnetic follower gently tapping the inner wall of the vessel. As a consequence the frequencies of the acoustic resonances in the vessel are reduced. This approach is called Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) which harnesses this phenomenon for many applications. The acid-carbonate experiments have also been validated using H 2 SO 4 acid and using both potassium and sodium counterions for the carbonate. This method can be used to interrogate strong acid-base reactions in a rapid and non-invasive manner using carbonate as the base. The data demonstrate the first example of a reactant also acting as an indicator. The applicability of the method to weak acids has yet to be determined. A novel conclusion from the study is that a person with a well-trained ear is capable of determining the concentration and pH of a strong acid just by listening. This brings pH measurement into the realm of human perception.

Safety and Effectiveness of the Denali Inferior Vena Cava Filter: Intermediate Follow-Up Results.

PubMed

Reis, Stephen P; Kovoor, Jerry; Sutphin, Patrick D; Toomay, Seth; Trimmer, Clayton; Pillai, Anil; Reddick, Mark; Kalva, Sanjeeva P

2016-08-01

The purpose of the study is to evaluate the clinical safety and effectiveness of the Denali (Bard, Tempe, Arizona) retrievable inferior vena cava (IVC) filter. In this retrospective study, authors reviewed the data of Denali IVC filters placed at their institution between 2013 and 2015. The clinical presentation, indications, and procedure-related complications during placement and retrieval were evaluated. The frequency of post filter pulmonary embolism (PE) and filter-related complications was assessed. Denali filters were placed in 87 patients (47 males; mean age: 56 years). Twenty patients presented with PE, 45 with deep vein thrombosis (DVT), and 21 with both PE and DVT, 1 filter was placed prophylactically before surgery. Indications for filter placement included contraindications to anticoagulation (AC; n = 80), failure of AC (n = 4), and complications of AC (n = 3). No patients had PE on follow-up imaging after filter placement. Retrieval was attempted in 31 patients after a mean period of 125 days (range: 34-324 days). The filter was successfully removed in 31 (100%) patients. Follow-up imaging, available in 71 (82%) patients (range: 2-538 days), demonstrated penetration of 15 legs in 5 patients, caval thrombus in 3, 1 resulting in caval occlusion, <15° filter tilt in 5, and no leg fractures or crossed legs. The Denali filter is safe during deployment and readily retrievable. The overall safety following deployment is similar to those reported in the literature, and the incidence of filter fractures and migration appears to be less than the previous generation of Bard devices. © The Author(s) 2016.

Risk factors for venous port migration in a single institute in Taiwan.

PubMed

Fan, Wen-Chieh; Wu, Cheng-Han; Tsai, Ming-Ju; Tsai, Ying-Ming; Chang, Hsu-Liang; Hung, Jen-Yu; Chen, Pei-Huan; Yang, Chih-Jen

2014-01-14

An implantable port device provides an easily accessible central route for long-term chemotherapy. Venous catheter migration is one of the rare complications of venous port implantation. It can lead to side effects such as pain in the neck, shoulder, or ear, venous thrombosis, and even life-threatening neurologic problems. To date, there are few published studies that discuss such complications. This retrospective study of venous port implantation in a single center, a Taiwan hospital, was conducted from January 2011 to March 2013. Venous port migration was recorded along with demographic and characteristics of the patients. Of 298 patients with an implantable import device, venous port migration had occurred in seven, an incidence rate of 2.3%. All seven were male and had received the Bard port Fr 6.6 which had smaller size than TYCO port Fr 7.5 and is made of silicon. Significantly, migration occurred in male patients (P = 0.0006) and in those with lung cancer (P = 0.004). Multivariable logistic regression analysis revealed that lung cancer was a significant risk factor for port migration (odds ratio: 11.59; P = 0.0059). The migration rate of the Bard port Fr 6.6 was 6.7%. The median time between initial venous port implantation and port migration was 35.4 days (range, 7 to 135 days) and 71.4% (5/7) of patients had port migration within 30 days after initial port implantation. Male sex and lung cancer are risk factors for venous port migration. The type of venous port is also an important risk factor.

GIS, GPS, political history, and geo-demography of the Aramamisi Yanomamo expansion

NASA Technical Reports Server (NTRS)

Chagnon, Napoleon A.

1991-01-01

This year a joint US-Venezuelan research project was initiated to locate, identify, and begin long term research on the ecology of the Siapa Basin and the cultural adaptations of Yanomamo communities to this habit, a poorly mapped region of southern Venezuela. During two separate field trips, representing over 500 hours of flying time, local informants were asked to guide a helicopter to villages and other areas of anthropological interest. The location of each place was established with a GPS instrument. Both the Trimble Navigation TransPak and Magellan Nav 1000 Pro were used on these trips. A brief summary of the results and preliminary comparisons of both instruments will be presented.

Inflight - Apollo XI (Mission Control Center [MCC]) - MSC

NASA Image and Video Library

1969-07-24

S69-40302 (24 July 1969) --- A group of NASA and Manned Spacecraft Center (MSC) officials join in with the flight controllers in the Mission Operations Control Room (MOCR) in the Mission Control Center (MCC), Building 30, in celebrating the successful conclusion of the Apollo 11 lunar landing mission. From left foreground are Dr. Maxime A. Faget, MSC Director of Engineering and Development; George S. Trimble, MSC Deputy Director; Dr. Christopher C. Kraft Jr., MSC Director of Flight Operations; Julian Scheer (in back), Assistant Administrator, Office of Public Affairs, NASA Headquarters; George M. Low, Manager, Apollo Spacecraft Program, MSC; Dr. Robert R. Gilruth, MSC Director; and Charles W. Mathews, Deputy Associate Administrator, Office of Manned Space Flight, NASA Headquarters.

Basic analysis of reflectometry data software package for the analysis of multilayered structures according to reflectometry data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Astaf'ev, S. B., E-mail: bard@ns.crys.ras.ru; Shchedrin, B. M.; Yanusova, L. G.

2012-01-15

The main principles of developing the Basic Analysis of Reflectometry Data (BARD) software package, which is aimed at obtaining a unified (standardized) tool for analyzing the structure of thin multilayer films and nanostructures of different nature based on reflectometry data, are considered. This software package contains both traditionally used procedures for processing reflectometry data and the authors' original developments on the basis of new methods for carrying out and analyzing reflectometry experiments. The structure of the package, its functional possibilities, examples of application, and prospects of development are reviewed.

A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice.

PubMed

Yamauchi, Keita; Nakano, Yusuke; Imai, Takahiko; Takagi, Toshinori; Tsuruma, Kazuhiro; Shimazawa, Masamitsu; Iwama, Toru; Hara, Hideaki

2016-10-01

Recanalization of occluded vessels leads to ischemia-reperfusion injury (IRI), with oxidative stress as one of the main causes of injury, despite the fact that recanalization therapy is the most effective treatment for ischemic stroke. The nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the transcription factors which has an essential role in protection against oxidative stress. RS9 is a novel Nrf2 activator obtained from bardoxolone methyl (BARD), an Nrf2 activator that has already been tested in a clinical trial, using a biotransformation technique. RS9 has been reported to lead to higher Nrf2 activation and less cytotoxicity than BARD. In this study, we investigated the effects of RS9 on IRI. Mice were intraperitoneally treated immediately after 2h of transient middle cerebral artery occlusion (MCAO) with a vehicle solution or 0.2mg/kg of RS9. Post-onset treatment of RS9 attenuated the infarct volume and improved neurological deficits 22h after reperfusion. RS9 activated Nrf2 2 and 6h after reperfusion and activated heme oxygenase-1 at 6 and 22h after reperfusion. RS9 also attenuated the phosphorylation of NF-κB p65 2 and 6h after reperfusion. Finally, RS9 improved the survival rate and neurological deficits 7days after MCAO. Our results suggest that the activation of Nrf2 by RS9 has a neuroprotective effect, mediated by attenuating both oxidative stress and neuroinflammation, and that RS9 is an effective therapeutic candidate for the treatment of IRI. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

Non-alcoholic fatty liver disease (NAFLD) fibrosis score predicts 6.6-year overall mortality of Chinese patients with NAFLD.

PubMed

Xun, Yun-Hao; Guo, Jian-Chun; Lou, Guo-Qiang; Jiang, Yan-Ming; Zhuang, Zhen-Jie; Zhu, Meng-Fei; Luo, Yan; Ma, Xiao-Jie; Liu, Jing; Bian, Dong-Xue; Shi, Jun-Ping

2014-09-01

The non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) has emerged as a useful predictor of long-term outcome in NAFLD patients. We evaluated the predictive performance of the NFS for overall mortality in a Chinese population with NAFLD. All NAFLD patients diagnosed ultrasonographically at Xixi Hospital of Hangzhou between 1996 and 2011 were retrospectively recruited to the study. Outcome was determined by interview and causes of death were confirmed by medical records. The area under the receiver operating characteristic curve (AUCROC ) was used to determine the predictive accuracy of the NFS, BARD (body mass index, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, diabetes) score, FIB-4 index and the AST/platelet ratio index (APRI) for mortality. Data from a total of 180 eligible patients (median age 39 years; 96 men) were analysed, with 12 deaths over a median follow-up period of 6.6 years (range 0.5-14.8 years). Using Cox model analysis, the NFS as a continuous variable was identified as the only predictor for all-cause mortality (hazard ratio 2.743, 95% confidence interval (CI) 1.670-4.504). The NFS yielded the highest AUCROC of 0.828 (95% CI 0.728-0.928, P < 0.05), followed by the FIB-4 index, APRI and BARD score (AUCROC 0.806 (P < 0.05), 0.732 (P < 0.05) and 0.632, respectively). The data indicated that the NFS is a useful predictor of 6.6-year all-cause mortality for Chinese patients with NAFLD. © 2014 Wiley Publishing Asia Pty Ltd.

Thermal and chemical denaturation of the BRCT functional module of human 53BP1.

PubMed

Thanassoulas, Angelos; Nomikos, Michail; Theodoridou, Maria; Stavros, Philemon; Mastellos, Dimitris; Nounesis, George

2011-10-01

BRCTs are protein-docking modules involved in eukaryotic DNA repair. They are characterized by low sequence homology with generally well-conserved structure organization. In a considerable number of proteins, a pair of BRCT structural repeats occurs, connected with inter-BRCT linkers, variable in length, sequence and structure. Linkers may separate and control the relative position of BRCT domains as well as protect and stabilize the hydrophobic inter-BRCT interface region. Their vital role in protein function has been demonstrated by recent findings associating missense mutations in the inter-repeat linker region of the BRCT domain of BRCA1 (BRCA1-BRCT) to hereditary breast/ovarian cancer. The interaction of 53BP1 with the core domain of the p53 tumor suppressor involves the C-terminal BRCT repeat as well as the inert-BRCT linker of the tandem BRCT domain of 53BP1 (53BP1-BRCT). High-accuracy differential scanning calorimetry (DSC) and circular dichroism (CD) have been employed to characterize the heat-induced unfolding of 53BP1-BRCT domain. The calorimetric results provide evidence for unfolding to an intermediate, only partly unfolded state, which, based on the CD results, retains the secondary structural characteristics of the native protein. A direct comparison with the corresponding thermal processes for BRAC1-BRCT and BARD1-BRCT provides evidence that the observed behavior is analogous to BRCA1-BRCT even though the two domains differ substantially in the linker structure. Moreover, chemical denaturation experiments of the untagged 53BP1-BRCT and comparison with BRCA1 and BARD1 BRCTs show that no clear association can be drawn between the structural organization of the inter-BRCT linkers and the overall stability of the BRCT domains. Copyright © 2011 Elsevier B.V. All rights reserved.

Reply to comment by E. Bard et al. on "Younger Dryas sea level and meltwater pulse 1B recorded in Barbados reef crest coral Acropora palmata" by N. A. Abdul et al.

NASA Astrophysics Data System (ADS)

Mortlock, Richard A.; Abdul, Nicole A.; Wright, James D.; Fairbanks, Richard G.

2016-12-01

Abdul et al. (2016) presented a detailed record of sea level at Barbados (13.9-9 kyr B.P.) tightly constraining the timing and amplitude during the Younger Dryas and Meltwater Pulse 1B (MWP-1B) based on U-Th dated reef crest coral species Acropora palmata. The Younger Dryas slow stand and the large (14 m) rapid sea level jump are not resolved in the Tahiti record. Tahiti sea level estimates are remarkably close to the Barbados sea level curve between 13.9 and 11.6 kyr but fall below the Barbados sea level curve for a few thousand years following MWP-1B. By 9 kyr the Tahiti sea level estimates again converge with the Barbados sea level curve. Abdul et al. (2016) concluded that Tahiti reefs at the core sites did not keep up with intervals of rapidly rising sea level during MWP-1B. We counter Bard et al. (2016) by showing (1) that there is no evidence for a hypothetical fault in Oistins Bay affecting one of the Barbados coring locations, (2) that the authors confuse the rare occurrences of A. palmata at depths >5 m with the "thickets" of A. palmata fronds representing the reef-crest facies, and (3) that uncertainties in depth habitat proxies largely account for differences in Barbados and Tahiti sea level differences curves with A. palmata providing the most faithful proxy. Given the range in Tahiti paleodepth uncertainties at the cored sites, the most parsimonious explanation remains that Tahiti coralgal ridges did not keep up with the sea level rise of MWP-1B.

High Dietary Sodium Intake Assessed by Estimated 24-h Urinary Sodium Excretion Is Associated with NAFLD and Hepatic Fibrosis

PubMed Central

Huh, Ji Hye; Lee, Kyong Joo; Lim, Jung Soo; Lee, Mi Young; Park, Hong Jun; Kim, Moon Young; Kim, Jae Woo; Chung, Choon Hee; Shin, Jang Yel; Kim, Hyun-Soo; Kwon, Sang Ok; Baik, Soon Koo

2015-01-01

Background Although high sodium intake is associated with obesity and hypertension, few studies have investigated the relationship between sodium intake and non-alcoholic fatty liver disease (NAFLD). We evaluated the association between sodium intake assessed by estimated 24-h urinary sodium excretion and NAFLD in healthy Koreans. Methods We analyzed data from 27,433 participants in the Korea National Health and Nutrition Examination Surveys (2008–2010). The total amount of sodium excretion in 24-h urine was estimated using Tanaka’s equations from spot urine specimens. Subjects were defined as having NAFLD when they had high scores in previously validated NAFLD prediction models such as the hepatic steatosis index (HSI) and fatty liver index (FLI). BARD scores and FIB-4 were used to define advanced fibrosis in subjects with NAFLD. Results The participants were classified into three groups according to estimated 24-h urinary excretion tertiles. The prevalence of NAFLD as assessed by both FLI and HSI was significantly higher in the highest estimated 24-h urinary sodium excretion tertile group. Even after adjustment for confounding factors including body fat and hypertension, the association between higher estimated 24-h urinary sodium excretion and NAFLD remained significant (Odds ratios (OR) 1.39, 95% confidence interval (CI) 1.26–1.55, in HSI; OR 1.75, CI 1.39–2.20, in FLI, both P < 0.001). Further, subjects with hepatic fibrosis as assessed by BARD score and FIB-4 in NAFLD patients had higher estimated 24-h urinary sodium values. Conclusions High sodium intake was independently associated with an increased risk of NAFLD and advanced liver fibrosis. PMID:26571018

The 3DBiopsy Prostate Biopsy System: Preclinical Investigation of a Needle, Actuator, and Specimen Collection Device Allowing Sampling of Individualized Prostate Lengths Between 20 and 60 mm.

PubMed

Stone, Nelson N; Mouraviev, Vladimir; Schechter, David; Lucia, M Scott; Smith, Elizabeth E; Arangua, Paul; Hoenemeyer, John; Rosa, Jim; Bawa, Rajan; Crawford, E David

2017-09-01

To increase the likelihood of detecting anterior cancers within the prostate and provide a specimen that spans the length of the gland. Newly designed 17- and 15-gauge (G) biopsy needles, a variable actuator, and an integrated pathology system intended for the longer cores were developed and tested for this purpose. Testing was performed comparing 2 common cannula tip grinds, a Vet-point (sharp tip) and a Menghini-point (atraumatic tip), and were tested against 18-G Bard Monopty in porcine kidney. A variable actuator was developed to fire the needle 20-60 mm and tested in cadaver prostates. The aggregate firings for 3 different shot lengths comparing the Vet- with the Menghini-tip cannulas demonstrated 91% vs 85.2% fill (length of specimen/length of core bed, P = .007). A 15-G trocar needle with the Vet-tip cannula also had the best performance, with an aggregate standard deviation of 6.4% across 3 firing ranges and a minimum to maximum specimen length of 81%-105% of potential fill. Cadaver testing with the Vet-tip needles in the actuator for the transrectal (17-G) and transperineal (15-G) biopsies demonstrated mean fills of 93.3% and 76.5%, respectively. The new transrectal ultrasound needle obtained a 2-fold increase in specimen length over the standard Bard device (P <.001). Longer and consistent cores were obtained using the new biopsy needles. Combined with an adjustable actuator, the physician can obtain specimens that include peripheral and anterior zone tissue in 1 core. Determination of cancer location on the longer specimens could enhance focal therapy planning. Copyright © 2017 Elsevier Inc. All rights reserved.

High Dietary Sodium Intake Assessed by Estimated 24-h Urinary Sodium Excretion Is Associated with NAFLD and Hepatic Fibrosis.

PubMed

Huh, Ji Hye; Lee, Kyong Joo; Lim, Jung Soo; Lee, Mi Young; Park, Hong Jun; Kim, Moon Young; Kim, Jae Woo; Chung, Choon Hee; Shin, Jang Yel; Kim, Hyun-Soo; Kwon, Sang Ok; Baik, Soon Koo

2015-01-01

Although high sodium intake is associated with obesity and hypertension, few studies have investigated the relationship between sodium intake and non-alcoholic fatty liver disease (NAFLD). We evaluated the association between sodium intake assessed by estimated 24-h urinary sodium excretion and NAFLD in healthy Koreans. We analyzed data from 27,433 participants in the Korea National Health and Nutrition Examination Surveys (2008-2010). The total amount of sodium excretion in 24-h urine was estimated using Tanaka's equations from spot urine specimens. Subjects were defined as having NAFLD when they had high scores in previously validated NAFLD prediction models such as the hepatic steatosis index (HSI) and fatty liver index (FLI). BARD scores and FIB-4 were used to define advanced fibrosis in subjects with NAFLD. The participants were classified into three groups according to estimated 24-h urinary excretion tertiles. The prevalence of NAFLD as assessed by both FLI and HSI was significantly higher in the highest estimated 24-h urinary sodium excretion tertile group. Even after adjustment for confounding factors including body fat and hypertension, the association between higher estimated 24-h urinary sodium excretion and NAFLD remained significant (Odds ratios (OR) 1.39, 95% confidence interval (CI) 1.26-1.55, in HSI; OR 1.75, CI 1.39-2.20, in FLI, both P < 0.001). Further, subjects with hepatic fibrosis as assessed by BARD score and FIB-4 in NAFLD patients had higher estimated 24-h urinary sodium values. High sodium intake was independently associated with an increased risk of NAFLD and advanced liver fibrosis.

Risk factors for venous port migration in a single institute in Taiwan

PubMed Central

2014-01-01

Background An implantable port device provides an easily accessible central route for long-term chemotherapy. Venous catheter migration is one of the rare complications of venous port implantation. It can lead to side effects such as pain in the neck, shoulder, or ear, venous thrombosis, and even life-threatening neurologic problems. To date, there are few published studies that discuss such complications. Methods This retrospective study of venous port implantation in a single center, a Taiwan hospital, was conducted from January 2011 to March 2013. Venous port migration was recorded along with demographic and characteristics of the patients. Results Of 298 patients with an implantable import device, venous port migration had occurred in seven, an incidence rate of 2.3%. All seven were male and had received the Bard port Fr 6.6 which had smaller size than TYCO port Fr 7.5 and is made of silicon. Significantly, migration occurred in male patients (P = 0.0006) and in those with lung cancer (P = 0.004). Multivariable logistic regression analysis revealed that lung cancer was a significant risk factor for port migration (odds ratio: 11.59; P = 0.0059). The migration rate of the Bard port Fr 6.6 was 6.7%. The median time between initial venous port implantation and port migration was 35.4 days (range, 7 to 135 days) and 71.4% (5/7) of patients had port migration within 30 days after initial port implantation. Conclusions Male sex and lung cancer are risk factors for venous port migration. The type of venous port is also an important risk factor. PMID:24423026

High FIB-4 index as an independent risk factor of prevalent chronic kidney disease in patients with nonalcoholic fatty liver disease.

PubMed

Xu, Huang-Wei; Hsu, Yung-Chien; Chang, Chia-Hao; Wei, Kuo-Liang; Lin, Chun-Liang

2016-03-01

Growing evidence suggests that non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk for chronic kidney disease (CKD); liver fibrosis with biopsy-proven NAFLD has also been shown to associate with an increased risk of CKD. This study compares the diagnostic performance of simple noninvasive tests in identifying prevalent CKD among individuals with ultrasonography-diagnosed NAFLD. A total of 755 with ultrasonography-diagnosed NAFLD were included. Estimated glomerular filtration rate and noninvasive markers for hepatic fibrosis: aspartate transaminase to alanine transaminase ratio (AAR), aspartate transaminase to platelet ratio index (APRI), FIB-4 score, NAFLD fibrosis score (NFS) and BARD score were assessed. Binary logistic regression to generate a propensity score and receiver operating characteristic curves were developed for each of the noninvasive markers for predicting CKD, and the area under the receiver operating characteristic curve was greatest for FIB-4 score (0.750), followed by NFS (0.710), AAR (0.594), APRI (0.587), and BARD score (0.561). A cut-off value of 1.100 for FIB-4 score gave a sensitivity of 68.85% and a specificity of 71.07% for predicting CKD. The positive predictive value and negative predictive value were 37.50 and 90.05%, respectively. In multiple logistic regression analysis, only FIB-4 score ≧1.100 (OR 2.660, 95% CI 1.201-5.889; p = .016), older age, higher diastolic blood pressure and higher uric acid were independent predictors of CKD. High noninvasive fibrosis score is associated with an increased risk of prevalent CKD; the FIB-4 is the better predictor. With a cut-off value of 1.100 for FIB-4, it is useful in excluding the presence of CKD in patients with NAFLD.

Pathologic findings in breast, fallopian tube, and ovary specimens in non-BRCA hereditary breast and/or ovarian cancer syndromes: a study of 18 patients with deleterious germline mutations in RAD51C, BARD1, BRIP1, PALB2, MUTYH, or CHEK2.

PubMed

Schoolmeester, J Kenneth; Moyer, Ann M; Goodenberger, McKinsey L; Keeney, Gary L; Carter, Jodi M; Bakkum-Gamez, Jamie N

2017-12-01

Germline BRCA mutations account for a significant proportion of genetic/familial risk of breast and ovarian cancer (GBOC) susceptibility, but a broader spectrum of GBOC susceptibility genes has emerged in recent years. Genotype-to-phenotype correlations are known for some established forms of GBOC; however, whether such correlations exist for less common GBOC variants is unclear. We reviewed our institution's experience with non-BRCA GBOC, looking specifically for trends in pathologic and clinical features. Eighteen women with deleterious germline mutations in RAD51C (5 patients), BARD1 (1 patient), BRIP1 (2 patients), PALB2 (3 patients), MUTYH (2 patients), or CHEK2 (5 patients) were identified between January 2011 and December 2016. Thirteen (72%) of 18 patients developed carcinoma of the breast, fallopian tube, or ovary, with 1 patient developing 2 separate primary neoplasms. Twelve (86%) of 14 tumors occurred in the breast. One (7%) arose in the fallopian tube and another (7%) arose in the ovary. Evidence of genotype-phenotype correlation was not identified. However, some data suggest that the type of alteration in select genes may influence tumor behavior and patient outcome. In our PALB2 mutation cohort, 2 patients with frameshift mutations led to early onset and rapid progression to stage IV breast cancer in contrast to stage IA breast cancer in 1 patient with a nonsense mutation. Despite no apparent genotype-phenotype trends, our data indicate that some loss-of-function variants in PALB2 may lead to differences in tumor behavior and patient outcome. Copyright © 2017 Elsevier Inc. All rights reserved.

Creating 3D models of historical buildings using geospatial data

NASA Astrophysics Data System (ADS)

Alionescu, Adrian; Bǎlǎ, Alina Corina; Brebu, Floarea Maria; Moscovici, Anca-Maria

2017-07-01

Recently, a lot of interest has been shown to understand a real world object by acquiring its 3D images of using laser scanning technology and panoramic images. A realistic impression of geometric 3D data can be generated by draping real colour textures simultaneously captured by a colour camera images. In this context, a new concept of geospatial data acquisition has rapidly revolutionized the method of determining the spatial position of objects, which is based on panoramic images. This article describes an approach that comprises inusing terrestrial laser scanning and panoramic images captured with Trimble V10 Imaging Rover technology to enlarge the details and realism of the geospatial data set, in order to obtain 3D urban plans and virtual reality applications.

New ROMP Synthesis of Ferrocenyl Dendronized Polymers.

PubMed

Liu, Xiong; Ling, Qiangjun; Zhao, Li; Qiu, Guirong; Wang, Yinghong; Song, Lianxiang; Zhang, Ying; Ruiz, Jaime; Astruc, Didier; Gu, Haibin

2017-10-01

First- and second-generation Percec-type dendronized ferrocenyl norbornene macromonomers containing, respectively, three and nine ferrocenyl termini are synthesized and polymerized by ring-opening metathesis polymerization using Grubbs' third-generation olefin metathesis catalyst with several monomer/catalyst feed ratios between 10 and 50. The rate of polymerization is highly dependent on the generation of the dendronized macromonomers, but all these ring-opening metathesis polymerization reactions are controlled, and near-quantitative monomer conversions are achieved. The numbers of ferrocenyl groups obtained are in agreement with the theoretical ones according to the cyclic voltammetry studies as determined using the Bard-Anson method. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Cancer Risks Associated with Inherited Mutations in Ovarian Cancer Susceptibility Genes Beyond BRCA1 and BRCA2

DTIC Science & Technology

2016-05-01

PALB2 (FANCO),MSH2, MLH1, MSH6, PMS2 , 9 other known breast cancer genes: ATM, CHEK2, FAM175A (abraxas), FAMCM, NBN, PTEN, RECQL, TP53 and XRCC2) and...patients were enrolled with a known mutation in a gene of interest including 1 each with a mutation in RAD51D, RAD51C, PALB2, BARD1, one with PMS2 ...BRCA2, PMS2 , BLM, RAD51C and 1 with mutations in MSH6 and RAD51D. Of the 48 patients with a second cancer, most had an invasive breast cancer, but

Anatomic changes of target vessels after fenestrated and branched aortic aneurysm repair.

PubMed

Kalder, J; Keschenau, P; Tamm, M; Jalaie, H; Jacobs, M J; Greiner, A

2014-04-01

Objective of this study was to evaluate the anatomic changes of the stented target vessels after endovascular repair of complex aortic aneurysms. Between July 2011 and December 2013, 53 aortic aneurysms were treated in our department with fenestrated and branched stent-graft devices. Forty-two of these patients were pre- and postoperatively scanned with a high resolution computer tomography (CT) (Cook Zenith® fenestrated or branched, Australia Pty. Ltd., Brisbane, Australia: N.=19; AnacondaTM fenestrated, Vascutek, Glasgow, Scotland, UK: N.=23). The other 11 out of the 53 patients did not receive a CT scan, because of a pre-existing renal failure. In the CT scans we retrospectively evaluated the anatomic vessel deviation at the origin of the target vessel and the vessel shift distal to the stent. For the first measurement the CT scans were loaded into OsiriX MD®, and the pre- and postoperative angles of the target vessels were measured and subtracted. For matching, the CT-scans were normalized at vertebral body lumbar 2. The second measured angle was the maximal measured angle distal to the target vessel stent-graft. Altogether, 113 target vessels were stented (celiac trunk [CT] 15, superior mesenteric arteries [SMA] 26, renal arteries [RA] 72), with 97 balloon-expandable PTFE stents: 90 Atrium V12 (Maquet Getinge group, Hudson, NH, USA), 7 BeGrafts (Bentley InnoMed, Hechingen, Germany) and 16 self-expandable fluency PTFE stents (Bard, Karlsruhe, Germany). The mean anatomic deviation at the target vessel origin was 28±17.3 and the mean vessel shift distal to the stent was 36.3±18.8. There were no significant differences between the main device and the target vessel stent types. Fenestrated and branched stent-graft solutions for aortic aneurysm repair induce changes of the target vessel anatomy. We did not observe significant differences between the several devices.

Paul B. Pedersen (1936-2017).

PubMed

Lonner, Walter J; Draguns, Juris G

2018-01-01

Presents an obituary for Paul B. Pedersen, who passed away on January 11, 2017, in a Minnetonka, Minnesota hospital. In 1973 Pedersen convened a pathfinding APA (Division 9) symposium in Montreal that resulted in the publication in 1976 of Counseling Across Cultures (Pedersen, Lonner, and Draguns, Eds.). The first book of its kind, it became the "Granddaddy" of all subsequent books in that area. The seventh edition, published in 2016 (with Trimble and Scharron-del Rio, co-eds), benefitted from his steadfast encouragement, but his deteriorating health prevented a more active role. His epitaph may well be one of his wisest and oft-quoted sayings: "All interviewing and counseling is multicultural. Each client comes to the session embodying multiple voices from the past." (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Implications of adolescents' acculturation strategies for personal and collective self-esteem.

PubMed

Giang, Michael T; Wittig, Michele A

2006-10-01

Berry, Trimble, and Olmedo's (1986) acculturation model was used to investigate the relationship among adolescents' acculturation strategies, personal self-esteem, and collective self-esteem. Using data from 427 high school students, factor analysis results distinguished Collective Self-esteem Scale constructs (Luhtanen & Crocker, 1992) from both ethnic identity and outgroup orientation subscales of the Multigroup Ethnic Identity Measure (Phinney, 1992). Subsequent results showed that: 1) both acculturation dimensions were correlated with personal and collective self-esteems, 2) integrationists shared similar levels of personal and collective self-esteems with assimilationists and/or separationists, and 3) marginalizationists generally had the lowest levels of personal and collective self-esteems. Implications are drawn for understanding acculturation among adolescents and for the utility of group-level measures of self-esteem. (c) 2006 APA, all rights reserved.

Barriers to the free diffusion of proteins and lipids in the plasma membrane.

PubMed

Trimble, William S; Grinstein, Sergio

2015-02-02

Biological membranes segregate into specialized functional domains of distinct composition, which can persist for the entire life of the cell. How separation of their lipid and (glyco)protein components is generated and maintained is not well understood, but the existence of diffusional barriers has been proposed. Remarkably, the physical nature of such barriers and the manner whereby they impede the free diffusion of molecules in the plane of the membrane has rarely been studied in depth. Moreover, alternative mechanisms capable of generating membrane inhomogeneity are often disregarded. Here we describe prototypical biological systems where membrane segregation has been amply documented and discuss the role of diffusional barriers and other processes in the generation and maintenance of their structural and functional compartmentalization. © 2015 Trimble and Grinstein.

Geodetic antenna calibration test in the Antarctic environment

USGS Publications Warehouse

Grejner-Brzezinska, A.; Vazquez, E.; Hothem, L.

2006-01-01

TransAntarctic Mountain DEFormation (TAMDEF) Monitoring Network is the NSF-sponsored OSU and USGS project, aimed at measuring crustal motion in the Transantarctic Mountains of Victoria Land using GPS carrier phase measurements. Station monumentation, antenna mounts, antenna types, and data processing strategies were optimized to achieve mm-level estimates for the rates of motion. These data contributes also to regional Antarctic frame definition. Significant amount of data collected over several years allow the investigation of unique aspects of GPS geodesy in Antarctica, to determine how the error spectrum compares to the mid-latitude regions, and to identify the optimum measurement and data processing schemes for Antarctic conditions, in order to test the predicted rates of motion (mm-level w.r.t. time). The data collection for the TAMDEF project was initiated in 1996. The primary antenna used has been the Ashtech L1/L2 Dorne Margolin (D/M) choke ring. A few occupations involved the use of a Trimble D/M choke ring. The data were processed using the antenna calibration data available from the National Geodetic Survey (NGS). The recent developments in new antenna designs that are lighter in weight and lower in cost are being considered as a possible alternative to the bulkier and more expensive D/M choke ring design. In November 2003, in situ testing of three alternative models of L1/L2 antennas was conducted at a site located in the vicinity of McMurdo Station, Antarctica (S77.87, E166.56). The antenna models used in this test were: Ashtech D/M choke ring, Trimble D/M choke ring, Trimble Zephyr, and the NovAtel GPS-702. Two stations, spaced within 30 meters, were used in the test. Both had the characteristics similar to the stations of the TAMDEF network, i.e., the UNAVCO fixed-height, force-centered level mounts with a constant antenna offset were used, ensuring extreme stability of the antenna/ mount/pin set up. During each of the four 3-day test data collection sessions, a reference station was occupied continuously with the Ashtech D/M choke ring antenna, while the second station was occupied by the tested antennas, one 3-day session for each antenna type. The coordinate differences were produced using software optimized for the analysis of data collected over short baselines. Each solution incorporated the NGS antenna calibration data appropriate for each antenna model. Hourly and 24-hour solutions were analyzed for repeatability and compared to the standard baseline coordinate differences. No significant variation was observed when comparing the same type of antennas and when switching antennas at the test site using daily solutions. An mm-level scatter can be observed comparing different antennas over the 1-hour solutions; it is smaller for the horizontal components, as compared to the vertical direction. At this point, it can be concluded that the standard antenna calibration models from NGS used for each antenna involved in this test did not result in any significant variation in the daily results, but with some in the hourly results. Thus, based on this fact, the antenna types tested here could be used in the future TAMDEF campaigns, where 24-hour solutions are normally used for deformation monitoring. These results can serve as good guidance to any future use of GPS equipment in Antarctica.

The ionospheric impact on GPS performance in southern polar region

USGS Publications Warehouse

Hong, C.-K.; Grejner-Brzezinska, D. A.; Arslan, N.; Willis, M.; Hothem, L.

2006-01-01

The primary objective of this paper is to present the results of the study of the effects of varying ionospheric conditions on the GPS signal tracking in the southern polar region. In the first stage of this study, the data collected by the OSU/USGS team in October-November 2003 within the TAMDEF (Transantarctic Mountains Deformation) network were used together with some IGS Antarctic stations to study the effect of severe ionospheric storms on GPS hardware. Note that TAMDEF is a joint USGS/OSU project with the primary objective of measuring crustal motion in the Transantarctic Mountains of Southern Victoria Land using GPS techniques. This study included ten Antarctic stations equipped with different dual-frequency GPS hardware, and the data were evaluated for two 24-hour periods of severe ionospheric storm (2003/10/29) and moderate ionospheric conditions (minor storm of 2003/11/11). The results of this study were presented at the LAG Assembly in Cairns, Australia (Grejner-Brzezinska et al., 2005). Additional tests, in a more controlled environment, were carried out at the US Antarctic station, McMurdo, between January 10 and February 6, 2006, under varying ionospheric conditions, where several different types of receivers were connected to the same antenna located on the rooftop of the Crary Laboratory (the primary test site). In this scenario, each antenna was subject to identical ionospheric effects during each day of the test, and no spatial decorrelation effects were present, as seen in the previous study, due to the spatial separation of the receivers tested. It should be noted, however, that no moderate or severe ionospheric storms occurred during the experiment, so, unfortunately, this type of conditions was not tested here. The test was repeated with different receivers connected to different antenna types; a total of four 5-day sessions were carried out. The following receiver types were used at the primary site: Trimble 5700, Ashtech Z-Surveyor, JNS Euro-80 and Novatel DL-4, with the following antennas: Trimble Zephyr Geodetic, Ashtech D/M and Ashtech E/M chokering. In addition, data collected by the MCM4 IGS station, MCMD UNAVCO station, and CRAR USGS station, all located within 300 m from the primary test site, were used in the analyses. These stations were equipped with the following receiver/antenna combinations: ADA SNR-12/AOAD/MJT chokering (MCM4), Trimble NETRS/AOAD/MJT chokering (MCMD), and TPS ODYSEY_E/JPSREGANT_DD_E (CRAR). The UNAVCO TEQC software was used to carry out the analyses. Depending on the data sampling rate and the mask angle, the expected numbers of observations per receiver/satellite were compared to the actual number of measurements collected during the ionospheric events, with a special emphasis on L2 data. A total number of cycle slips and losses of lock were computed and compared among the hardware types. The results presented here indicate that there is no significant effects on the GPS receivers during minor ionospheric storms (Kp<5). However, the results reported in ibid, indicate significant differences in the hardware performance under severe ionospheric storms. Thus, careful hardware selection is needed to assure data quality/continuity when observations may be affected by severe ionospheric disturbances, while under calm to minor ionospheric activity level there is no significant difference in performance among the hardware tested here.

Popular culture and sporting life in the rural margins of late eighteenth-century England: the world of Robert Anderson, "The Cumberland Bard".

PubMed

Huggins, Mike

2012-01-01

This study sets out to extend and challenge existing historiography on late eighteenth century British popular culture, customary sports, class and cultural identity, focusing upon the rural geo-political borderland of England. It suggests that prevailing class-based and more London-biased studies need to be balanced with more regionalist-based work, and shows the importance of northern regional leisure variants. The textual and historical analysis draws largely on the published works of a neglected working-class dialect poet, Robert Anderson, living and working in Cumberland, arguing that he represented a strain of ''bardic regionalism,'' a variant of Katie Trumpener’s ''bardic nationalism.''

Centimeter-Level Robust Gnss-Aided Inertial Post-Processing for Mobile Mapping Without Local Reference Stations

NASA Astrophysics Data System (ADS)

Hutton, J. J.; Gopaul, N.; Zhang, X.; Wang, J.; Menon, V.; Rieck, D.; Kipka, A.; Pastor, F.

2016-06-01

For almost two decades mobile mapping systems have done their georeferencing using Global Navigation Satellite Systems (GNSS) to measure position and inertial sensors to measure orientation. In order to achieve cm level position accuracy, a technique referred to as post-processed carrier phase differential GNSS (DGNSS) is used. For this technique to be effective the maximum distance to a single Reference Station should be no more than 20 km, and when using a network of Reference Stations the distance to the nearest station should no more than about 70 km. This need to set up local Reference Stations limits productivity and increases costs, especially when mapping large areas or long linear features such as roads or pipelines. An alternative technique to DGNSS for high-accuracy positioning from GNSS is the so-called Precise Point Positioning or PPP method. In this case instead of differencing the rover observables with the Reference Station observables to cancel out common errors, an advanced model for every aspect of the GNSS error chain is developed and parameterized to within an accuracy of a few cm. The Trimble Centerpoint RTX positioning solution combines the methodology of PPP with advanced ambiguity resolution technology to produce cm level accuracies without the need for local reference stations. It achieves this through a global deployment of highly redundant monitoring stations that are connected through the internet and are used to determine the precise satellite data with maximum accuracy, robustness, continuity and reliability, along with advance algorithms and receiver and antenna calibrations. This paper presents a new post-processed realization of the Trimble Centerpoint RTX technology integrated into the Applanix POSPac MMS GNSS-Aided Inertial software for mobile mapping. Real-world results from over 100 airborne flights evaluated against a DGNSS network reference are presented which show that the post-processed Centerpoint RTX solution agrees with the DGNSS solution to better than 2.9 cm RMSE Horizontal and 5.5 cm RMSE Vertical. Such accuracies are sufficient to meet the requirements for a majority of airborne mapping applications.

Progress on Suffa Large Radiotelescope Project

NASA Astrophysics Data System (ADS)

Shanin, G. I.; Hojaev, A. S.

2006-08-01

The large-scale radio astronomy facility complex (analogous to the GBT at NRAO) is being created not far from Samarkand (Uzbekistan) on Suffa plateau at 2300 m (Trimble,2001). Originally it was designed as a basic part of the Earth-Space VLBI system (Kardashev et al,1995; URL http://www.asc.rssi.ru/suffa/) and contains the radio telescope for 0.8-60 mm band with 70 [Author ID2: at Fri Jul 14 10:39:00 2006 ]m main reflector, two removable subreflectors; satellite communication station; data receiving and processing system and other necessary infrastructure. The adaptive optics principle will be used for control the surface of the main mirror consisted of 1200 trapezoid panels. The site location provides good seeing conditions for cm-mm range. Averaged annual atmospheric transmission coefficients at zenith were derived as 0.90-0.98 for 3.1 mm and 5.8 mm wavelengths and about 0.60 for 1.36 (Hojaev & Shanin, 1996). The project started as far back as the period of the Soviet Union was stalled since its disintegration. Quite recently the firm decision on completing the project has been endorsed by our Governments, and Russia will invest for these; therefore the project's layouts have been considerably modernizated and updated in order to build up the state-of-art instrument. It should be operational in 2009. Now we are arranging the scientific consortium to further explore the Suffa site more deep and to learn the main 'radio astro climate' parameters by means of a new technology ('radioseeing', radio transparency in different submm, mm and cm bands, PWV, their intercorrelation and correlation with meteoparameters) for the atmosphere modelling at the site and try to forecast the "radio-weather" for reliably planning the scientific schedule of the future telescope. References: Kardashev N.S., Andreyanov V.V., Gvamichava A.S., Likhachev S.F., and Slysh V.I., 1995, , Acta Astronautica, vol.37, p.271 Hojaev A.S., Shanin G.I., 1996, JKAS, v.29 , p.S411 Trimble, V., 2001, A Year of Discovery: Astronomy Highlights of 2000, Sky and Telescope, vol.101, N.2, p.51

Progress on Suffa Large Radiotelescope Project

NASA Astrophysics Data System (ADS)

Shanin, G. I.; Hojaev, A. S.

2006-08-01

The large-scale radio astronomy facility complex (analogous to the GBT at NRAO) is being created not far from Samarkand (Uzbekistan) on Suffa plateau at 2300 m (Trimble,2001). Originally it was designed as a basic part of the Earth-Space VLBI system (Kardashev et al,1995; URL http://www.asc.rssi.ru/suffa/) and contains the radio telescope for 0.8-60 mm band with 70m main reflector, two removable subreflectors; satellite communication station; data receiving and processing system and other necessary infrastructure. The adaptive optics principle will be used for control the surface of the main mirror consisted of 1200 trapezoid panels. The site location provides good seeing conditions for cm-mm range. Averaged annual atmospheric transmission coefficients at zenith were derived as 0.90-0.98 for 3.1 mm and 5.8 mm wavelengths and about 0.60 for 1.36 (Hojaev & Shanin, 1996). The project started as far back as the period of the Soviet Union was stalled since its disintegration. Quite recently the firm decision on completing the project has been endorsed by our Governments, and Russia will invest for these; therefore the project's layouts have been considerably modernizated and updated in order to build up the state-of-art instrument. It should be operational in 2009. Now we are arranging the scientific consortium to further explore the Suffa site more deep and to learn the main 'radio astro climate' parameters by means of a new technology ('radioseeing', radio transparency in different submm, mm and cm bands, PWV , their intercorrelation and correlation with meteoparameters) for the atmosphere modelling at the site and try to forecast the "radio-weather" for reliably planning the scientific schedule of the future telescope. References: Kardashev N.S., Andreyanov V.V., Gvamichava A.S., Likhachev S.F., and Slysh V.I., 1995, , Acta Astronautica, vol.37, p.271 Hojaev A.S., Shanin G.I., 1996, JKAS, v.29 , p.S411 Trimble, V., 2001, A Year of Discovery: Astronomy Highlights of 2000, Sky and Telescope, vol.101, N.2, p.51

The Plate Boundary Observatory Cascadia Network: Development and Installation of a Large Scale Real-time GPS Network

NASA Astrophysics Data System (ADS)

Austin, K. E.; Blume, F.; Berglund, H. T.; Feaux, K.; Gallaher, W. W.; Hodgkinson, K. M.; Mattioli, G. S.; Mencin, D.

2014-12-01

The EarthScope Plate Boundary Observatory (PBO), through a NSF-ARRA supplement, has enhanced the geophysical infrastructure in in the Pacific Northwest by upgrading a total of 282 Plate Boundary Observatory GPS stations to allow the collection and distribution of high-rate (1 Hz), low-latency (<1 s) data streams (RT-GPS). These upgraded stations supplemented the original 100 RT-GPS stations in the PBO GPS network. The addition of the new RT-GPS sites in Cascadia should spur new volcano and earthquake research opportunities in an area of great scientific interest and high geophysical hazard. Streaming RT-GPS data will enable researchers to detect and investigate strong ground motion during large geophysical events, including a possible plate-interface earthquake, which has implications for earthquake hazard mitigation. A Mw 6.9 earthquake occurred on March 10, 2014, off the coast of northern California. As a response, UNAVCO downloaded high-rate GPS data from Plate Boundary Observatory stations within 500 km of the epicenter of the event, providing a good test of network performance.In addition to the 282 stations upgraded to real-time, 22 new meteorological instruments were added to existing PBO stations. Extensive testing of BGAN satellite communications systems has been conducted to support the Cascadia RT-GPS upgrades and the installation of three BGAN satellite fail over systems along the Cascadia margin will allow for the continuation of data flow in the event of a loss of primary communications during in a large geophysical event or other interruptions in commercial cellular networks. In summary, with these additional upgrades in the Cascadia region, the PBO RT-GPS network will increase to 420 stations. Upgrades to the UNAVCO data infrastructure included evaluation and purchase of the Trimble Pivot Platform, servers, and additional hardware for archiving the high rate data, as well as testing and implementation of GLONASS and Trimble RTX positioning on the receivers. UNAVCO staff is working closely with the UNAVCO community to develop data standards, protocols, and a science plan for the use of RT-GPS data.

COCONet enhancements to circum-Caribbean tsunami warning, tidal, and sea-level monitoring: update on tide gauge installations

NASA Astrophysics Data System (ADS)

Dausz, K.; Dittmann, S. T.; Feaux, K.; von Hillebrandt-Andrade, C.; Mattioli, G. S.; Normandeau, J.

2014-12-01

The Continually Operating Caribbean GPS Observational Network (COCONet) is a National Science Foundation (NSF) funded multi-hazard geodetic and meteorological network distributed throughout the Caribbean, which provides infrastructure and capacity building for a broad range of earth science questions. The network is a multi-national collaboration consisting of 46 newly constructed continuous Global Positioning Systems (cGPS) and 21 refurbished existing GPS stations, all co-located with meteorological sensors. One recommendation of the COCONet working group was to improve the vertical reference frame for long-term sea level monitoring. A COCONet supplement was awarded by the NSF to further address this particular objective through the co-location of GPS and tide gauges. This COCOnet infrastructure, along with the new tide gauges, will have broad scientific implications for hazards mitigation, solid earth, and atmospheric science research. UNAVCO engineers have meet with members of the Caribbean tide gauge community to establish target locations and design station layout. Allocated NSF funds allow for the construction of two complete new tide gauge systems each with two complimentary cGPS. Following the recommendations of NOAA and the sea level monitoring community, the two "new" locales will be Port Royal, Jamaica and Puerto Morelos, Mexico. Both locations had previously existing, but currently non-operational tide gauges. UNAVCO engineers will install a Sutron Radar Level Recorder and a backup pressure sensor tide gauge with GOES satellite telemetry. Tide data will be freely available by the Intergovernmental Oceanographic Commission (www.ioc-sealevelmonitoring.org). The NSF supplement also provided funds for adding cGPS to two additional locations where currently functioning tide gauge systems exist. Proposed locations for this additional infrastructure are Barahona, Dominican Republic and Bocas del Toro, Panama. All four locations will feature two standard COCONet cGPS systems consisting of a Trimble Choke Ring GNSS antenna, Trimble NetR9 GPS receiver, and a Vaisala meteorological sensor. All GPS data will be collected, processed and distributed via standard COCONet archiving and processing along with raw meteorological data at coconet.unavco.org.

Suboptimal performance of simple noninvasive tests for advanced fibrosis in Chinese patients with nonalcoholic fatty liver disease.

PubMed

Xun, Yun Hao; Fan, Jian Gao; Zang, Guo Qing; Liu, Hong; Jiang, Yan Ming; Xiang, Jing; Huang, Qian; Shi, Jun Ping

2012-11-01

To evaluate the diagnostic accuracy of some noninvasive fibrosis models in Chinese patients with nonalcoholic fatty liver disease (NAFLD). Consecutive biopsy-proven NAFLD patients were recruited from a single center from January 2005 to December 2010. Advanced fibrosis (stage 3 and 4) was defined using Kleiner criteria. The area under the receiver operating characteristic curve (AUROC) was used to compare the diagnostic accuracy of the NAFLD fibrosis score (NFS), FIB-4 index, aspartate transaminase (AST)/platelet ratio index (APRI), AST/alanine transaminase (ALT) ratio (AAR) and body mass index (BMI)-AAR-Diabetes (BARD) score. Of the patients with NAFLD, 79.6% were males with a mean age of 37.1 years, mean BMI of 26.1 kg/m(2) and 41.4% of them had nonalcoholic steatohepatitis, and 24 (15.8%) had advanced fibrosis. The AUROC of the FIB-4 index, APRI, AAR, NFS and BARD score for advanced fibrosis were 0.756, 0.742, 0.670, 0.653 and 0.642 (P < 0.05 for all), respectively. A concordant negative predictive value of approximately 90% was indicated whereas the positive predictive values were modest for all tests, and only the FIB-4 index yielded a higher positive likelihood ratio of 7.65. Using these cut-off values of tests for excluding advanced fibrosis could reduce the use of liver biopsy in 56.6-74.3% of the patients, with a minor false negative rate of 5.3-9.9%. Although slightly less accurate than liver biopsy, simple noninvasive tests can reliably exclude advanced fibrosis in Chinese NAFLD patients in our center. FIB-4 index performs better than the other tests under examination. © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Biomechanical evaluation of potential damage to hernia repair materials due to fixation with helical titanium tacks.

PubMed

Lerdsirisopon, Sopon; Frisella, Margaret M; Matthews, Brent D; Deeken, Corey R

2011-12-01

This study aimed to determine whether the strength and extensibility of hernia repair materials are negatively influenced by the application of helical titanium tacks. This study evaluated 14 meshes including bare polypropylene, macroporous polytetrafluoroethylene, absorbable barrier, partially absorbable mesh, and expanded polytetrafluoroethylene materials. Each mesh provided 15 specimens, which were prepared in 7.5 × 7.5-cm squares. Of these, 5 "undamaged" specimens were subjected to ball-burst testing to determine their biomechanical properties before application of helical titanium tacks (ProTack). To 10 "damaged" specimens 7 tacks were applied 1 cm apart in a 3.5-cm-diameter circle using a tacking force of 25 to 28 N. The tacks were removed from five of the specimens before ball-burst testing and left intact in the remaining five specimens. The application of tacks had no effect on the tensile strength of Dualmesh, ProLite Ultra, Infinit, Ultrapro, C-QUR Lite (<6 in.), Prolene Soft, or Physiomesh, but the tensile strengths were reduced for Bard Mesh, C-QUR, ProLite, and C-QUR Lite (>6 in.). Most of the meshes did not exhibit significantly different tensile strengths between removal of tacks and tacks left intact. Exceptions included C-QUR, Prolene, Ultrapro, and Bard Soft Mesh, which were weaker with removal of tacks than with tacks left intact during the test. Damage due to the application of helical titanium tacks also caused increased strain at a stress of 16 N/cm for all the meshes except C-QUR Lite (>6 in.) and Physiomesh. Many of the meshes evaluated in this study exhibited damage in the form of reduced tensile strength and increased extensibility after the application of tacks compared with the corresponding "undamaged" meshes. Meshes with smaller interstices and larger filaments were influenced negatively by the application of helical titanium tacks, whereas mesh designs with larger interstices and smaller filaments tended to maintain their baseline mechanical properties.

A New Reading of Shakespeare's Hamlet.

NASA Astrophysics Data System (ADS)

Usher, P. D.

1996-12-01

I argue that Hamlet is an allegory for the competition between the cosmological models of the contemporaries Thomas Digges (1546-1595) of England and Tycho Brahe (1546-1601) of Denmark. Through his acquaintance with the Digges' family, Shakespeare would have known of the essential elements of the revolutionary model of Nicholas Copernicus (1473-1543) as well as Digges' extension of it. Prior to 1601 when the writing of Hamlet was completed, Shakespeare knew also of Tycho and his relatives Rosencrantz and Guildenstern, and would have seen that Tycho's hybrid geocentric model was a substantial regression to the well-known geocentricism of Ptolemy (fl. 140 A.D.). It has been suggested that Polonius is named for a fictional character Pollinio, an Aristotelian pedant. I suggest that Claudius is named for Claudius Ptolemy for whom Polonius would have been a suitable attendant. I suggest further that the slaying of Rosencrantz and Guildenstern is the Bard's way of killing the Tychonic model. The slaying of Claudius signals the demise of Ptolemaic geocentricism, both ends being prolonged, the former dramatically, the latter as a matter of historical fact. But the climax of the play is not the slaughter of the chief protagonists; it is the triumphal arrival of Fortinbras from Poland and his timely salute to the ambassadors from England. By means of this apparent incongruity, Shakespeare celebrates the Copernican and Diggesian models and states poetically the nature of the new universal order. I present literary and historical evidence for the present reading which, if essentially correct, suggests that Hamlet evinces a scientific cosmology no less significant than its literary and philosophical counterparts. The last year of the sixteenth century saw the martyrdom of Bruno, but the first year of the next century saw the Bard affirm that there are more things in heaven than were dreamt of in contemporary philosophy.

Contextualizing Solar Cycle 24: Report on the Development of a Homogenous Database of Bipolar Active Regions Spanning Four Cycles

NASA Astrophysics Data System (ADS)

Munoz-Jaramillo, A.; Werginz, Z. A.; DeLuca, M. D.; Vargas-Acosta, J. P.; Longcope, D. W.; Harvey, J. W.; Martens, P.; Zhang, J.; Vargas-Dominguez, S.; DeForest, C. E.; Lamb, D. A.

2015-12-01

The solar cycle can be understood as a process that alternates the large-scale magnetic field of the Sun between poloidal and toroidal configurations. Although the process that transitions the solar cycle between toroidal and poloidal phases is still not fully understood, theoretical studies, and observational evidence, suggest that this process is driven by the emergence and decay of bipolar magnetic regions (BMRs) at the photosphere. Furthermore, the emergence of BMRs at the photosphere is the main driver behind solar variability and solar activity in general; making the study of their properties doubly important for heliospheric physics. However, in spite of their critical role, there is still no unified catalog of BMRs spanning multiple instruments and covering the entire period of systematic measurement of the solar magnetic field (i.e. 1975 to present).In this presentation we discuss an ongoing project to address this deficiency by applying our Bipolar Active Region Detection (BARD) code on full disk magnetograms measured by the 512 (1975-1993) and SPMG (1992-2003) instruments at the Kitt Peak Vacuum Telescope (KPVT), SOHO/MDI (1996-2011) and SDO/HMI (2010-present). First we will discuss the results of our revitalization of 512 and SPMG KPVT data, then we will discuss how our BARD code operates, and finally report the results of our cross-callibration.The corrected and improved KPVT magnetograms will be made available through the National Solar Observatory (NSO) and Virtual Solar Observatory (VSO), including updated synoptic maps produced by running the corrected KPVT magnetograms though the SOLIS pipeline. The homogeneous active region database will be made public by the end of 2017 once it has reached a satisfactory level of quality and maturity. The Figure shows all bipolar active regions present in our database (as of Aug 2015) colored according to the sign of their leading polarity. Marker size is indicative of the total active region flux. Anti-Hale regions are shown using solid markers.

Cecilia Payne-Gaposchkin, An Autobiography and Other Recollections

NASA Astrophysics Data System (ADS)

Haramundanis, Katherine

Cecilia Payne-Gaposchkin became acclaimed in her lifetime as the greatest woman astronomer of all time. Her own story of her professional life, work and scientific achievements is augmented by the personal recollections of her daughter, Katherine Haramundanis, as well as a scientific appreciation by Jesse Greenstein, a historical essay by Peggy Kidwell and, in this new edition, an introduction by Virginia Trimble. Payne-Gaposchkin's overwhelming love for astronomy was her personal guiding light, and her attitude and approach have lessons for all. She received many prestigious awards for her outstanding contributions to science and in 1956 became the first woman to be advanced to the rank of Professor at Harvard University, as well as being the first woman departmental chair. This book will interest both astronomers and those studying the advancement of the position and status of women in society.

Physical Habitat Characteristics on the North and South Forks of the Shenandoah River, VA in 2002-2007

USGS Publications Warehouse

Krstolic, Jennifer L.; Hayes, Donald C.

2010-01-01

Data collected with the GeoXT Trimble GPS unit using ArcPad 6.1. (summer 2006-2007). Files were created within a geodatabase to create a data dictionary for use in ArcPad during data collection. Drop down lists for habitat type, substrate, depth, width, length, and descriptions were included. Data files produced on the GeoXT were point shapefiles that could be checked back into the geodatabase and viewable as a layer. Points were gathered while canoeing along the South Fork Shenandoah River. Each location marked a change in meso-scale habitat type. GPS points were supplemented with GIS-derived points in areas where manual measurements were made. The points were used to generate a line coverage. This coverage represents physical habitat at a meso-scale (width of stream).

Measurement of the integrated Luminosities of cross-section scan data samples around the $${\\rm{\\psi }}$$(3770) mass region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ablikim, M.; Achasov, M. N.; Ahmed, S.

To investigate the nature of the (3770) resonance and to measure the cross section for e +e -→Dmore » $$\\bar{D}$$, a cross-section scan data sample, distributed among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the BESIII detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data sample at each center-of-mass energy point. The total integrated luminosity of the data sample is 76.16±0.04±0.61 pb -1, where the first uncertainty is statistical and the second systematic.« less

Shakespeare's chancre: did the bard have syphilis?

PubMed

Ross, John J

2005-02-01

Shakespeare's obsessive interest in syphilis, his clinically exact knowledge of its manifestations, the final poems of the sonnets, and contemporary gossip all suggest that he was infected with "the infinite malady." The psychological impact of venereal disease may explain the misogyny and revulsion from sex so prominent in the writings of Shakespeare's tragic period. This article examines the possibility that Shakespeare received successful treatment for syphilis and advances the following new hypothesis: Shakespeare's late-life decrease in artistic production, tremor, social withdrawal, and alopecia were due to mercury poisoning from syphilis treatment. He may also have had anasarca due to mercury-related membranous nephropathy. This medical misadventure may have prematurely ended the career of the greatest writer in the English language.

Measurement of the integrated Luminosities of cross-section scan data samples around the $${\\rm{\\psi }}$$(3770) mass region

DOE PAGES

Ablikim, M.; Achasov, M. N.; Ahmed, S.; ...

2018-05-01

To investigate the nature of the (3770) resonance and to measure the cross section for e +e -→Dmore » $$\\bar{D}$$, a cross-section scan data sample, distributed among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the BESIII detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data sample at each center-of-mass energy point. The total integrated luminosity of the data sample is 76.16±0.04±0.61 pb -1, where the first uncertainty is statistical and the second systematic.« less

A multicentre prospective randomised study of single-incision mini-sling (Ajust®) versus tension-free vaginal tape-obturator (TVT-O™) in the management of female stress urinary incontinence: pain profile and short-term outcomes.

PubMed

Mostafa, Alyaa; Agur, Wael; Abdel-All, Mohamed; Guerrero, Karen; Lim, Chi; Allam, Mohamed; Yousef, Mohamed; N'Dow, James; Abdel-fattah, Mohamed

2012-11-01

To compare the postoperative pain profile, peri-operative details, and short-term patient-reported and objective success rates of single-incision mini-slings (SIMS) versus standard mid-urethral slings (SMUS). In a multicentre prospective randomised trial in six UK centres in the period between October 2009 and October 2010, 137 women were randomised to either adjustable SIMS (Ajust®, C. R. Bard Inc., NJ, USA), performed under local anaesthesia as an opt-out policy (n=69), or SMUS (TVT-O™, Ethicon Inc., Somerville, USA) performed under general anaesthesia (n=68). Randomisation was done through number-allocation software and using telephone randomisation. Postoperative pain profile (primary outcome) was assessed on a ten-point visual analogue scale at fixed time-points. Pre- and post operatively (4-6 months) women completed symptom severity, urgency perception scale (UPS), quality of life and sexual function questionnaires. In addition, women completed a Patient Global Impression of Improvement Questionnaire and underwent a cough stress test at 4-6 months follow up. Sample size calculation was performed and data were analysed using SPSS 18. Descriptive analyses are given and between-group comparisons were performed using chi-square, Fischer exact test and Mann-Whitney test as appropriate. Significance level was set at 5%. Women in the SIMS Ajust® group had a significantly lower postoperative pain profile up to 4 weeks (p=<0.001, 95% CI 1.151, 2.480). There was no significant difference in peri-operative complications between groups. All 137 women completed the 4-6 months follow-up. Patient-reported and objective cure rates were not significantly different: 85.5% versus 91.2% (p=0.443) and 90% versus 97% (p=0.165) between the SIMS Ajust® and TVT-O™ groups respectively. There was a trend towards higher rates of de novo urgency or worsening of pre-existing urgency in the SIMS Ajust® group (21.7% versus 8.8%) but this did not reach statistical significance (p=0.063). Women in the SIMS Ajust® group had shorter hospital stay (median (IQR) 3.65 (2.49, 4.96)) compared to (4.42 (3.16, 5.56)) the TVT-O™ group 95% CI (-0.026, 1.326), with significantly earlier return to normal activities (p=0.025) and to work (p=0.006). The adjustable single-incision mini-sling (Ajust®) is associated with a significantly improved postoperative pain profile and earlier return to work when compared to standard mid-urethral slings (TVT-O™), with encouraging results in patient-reported and objective success rates at short-term follow-up. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Recent Measurement of Flavor Asymmetry of Antiquarks in the Proton by Drell–Yan Experiment SeaQuest at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagai, Kei

A measurement of the flavor asymmetry of the antiquarks (more » $$\\bar{d}$$ and $$\\bar{u}$$) in the proton is described in this thesis. The proton consists of three valence quarks, sea quarks, and gluons. Antiquarks in the proton are sea quarks. They are generated from the gluon splitting: g → q + $$\\bar{q}$$. According to QCD (Quantum Chromodynamics), the gluon splitting is independent of quark flavor. It suggests that the amounts of $$\\bar{d}$$ and $$\\bar{u}$$ should be the same in the proton. However, the NMC experiment at CERN found that the amount of $$\\bar{d}$$ is larger than that of $$\\bar{u}$$ in the proton using the deep inelastic scattering in 1991. This result is obtained for $$\\bar{d}$$ and $$\\bar{u}$$ integrated over Bjorken x. Bjorken x is the fraction of the momentum of the parton to that of the proton. The NA51 experiment (x ~ 0.2) at CERN and E866/NuSea experiment (0.015 < x < 0.35) at Fermilab measured the flavor asymmetry of the antiquarks ($$\\bar{d}$$/$$\\bar{u}$$) in the proton as a function of x using Drell–Yan process. The experiments reported that the flavor symmetry is broken over all measured x values. Understanding the flavor asymmetry of the antiquarks in the proton is a challenge of the QCD. The theo- retical investigation from the first principle of QCD such as lattice QCD calculation is important. In addition, the QCD effective models and hadron models such as the meson cloud model can also be tested with the flavor asymmetry of antiquarks. From the experimental side, it is important to measure with higher accuracy and in a wider x range. The SeaQuest (E906) experiment measures $$\\bar{d}$$/$$\\bar{u}$$ at large x (0.15 < x < 0.45) accurately to understand its behavior. The SeaQuest experiment is a Drell–Yan experiment at Fermi National Accelerator Laboratory (Fermilab). In the Drell–Yan process of proton-proton reaction, an antiquark in a proton and a quark in another proton annihilate and create a virtual photon, which then decays into a muon pair (q$$\\bar{q}$$ → γ* → µ +µ -). The SeaQuest experiment uses a 120 GeV proton beam extracted from Fermilab’s Main Injector. The proton beam interacts with hydrogen and deuterium targets. The SeaQuest spectrometer detects the muon pairs from the Drell–Yan process. The $$\\bar{d}$$/$$\\bar{u}$$ ratio at 0.1 < x < 0.58 is extracted from the number of detected Drell–Yan muon pairs. After the detector construction, commissioning run and detector upgrade, the SeaQuest experiment started the physics data acquisition from 2013. We finished so far three periods of physics data acquisition. The fourth period is in progress. The detector construction, detector performance evaluation, data taking and data analysis for the flavor asymmetry of the antiquarks $$\\bar{d}$$/$$\\bar{u}$$ in the proton are my contribution to SeaQuest. The cross section ratio of Drell–Yan process in p- p and p-d reactions is obtained from dimuon yields. In the experiment with high beam intensity, it is important to control the tracking efficiency of charged particles through the magnetic spectrometer. The tracking efficiency depends on the chamber occupancy, and the appropriate method for the correction is important. The chamber occupancy is the number of hits in drift chambers. A new method of the correction for the tracking efficiency is developed based on the occupancy, and applied to the data. This method reflects the real response of the drift chambers. Therefore, the systematic error is well controlled by this method. The flavor asymmetry of antiquarks is obtained at 0.1 < x < 0.58. At 0.1 < x < 0.45, the result is $$\\bar{d}$$/$$\\bar{u}$$ > 1. The result at 0.1 < x < 0.24 agrees with the E866 result. The result at x > 0.24, however, disagrees with the E866 result. The result at 0.45 < x < 0 the statistical errors. u¯ results extracted from experiments are used to investigate the validity of the theoretical models. The present experimental result provides the data points in wide x region. It is useful for understanding the proton structure in the light of QCD and effective hadron models. The present result has a practical application as well. Antiquark distributions are important as inputs to simulations of hadron reactions such as W± production in various experiments. The new knowledge on antiquark distributions helps to improve the precision of the simulations.« less

Cecilia Payne-Gaposchkin

NASA Astrophysics Data System (ADS)

Payne-Gaposchkin, Cecilia; Haramundanis, Katherine; Greenstein, Introduction by Jesse; Trims, Virginia; Kidwell, Peggy

1996-03-01

Cecilia Payne-Gaposchkin: an Introduction Virginia Trimble; An introduction to The Dyer's Hand Jesse L. Greenstein; A historical introduction to The Dyer's Hand Peggy A. Kidwell; A personal recollection Katherine Haramundanis; The Dyer's Hand: an autobiography Cecilia Payne-Gaposchkin; Dedication; Foreword; Part I. The Vision Splendid: 1. Backgrounds; 2. Beginnings; 3. Prelude to education; 4. Birth of a dream; 5. Dramatic interlude; 6. The dream fulfilled; 7. Pathway to the stars; Part II. The Light Of Common Day: 8. England and the United States; 9. Harvard College Observatory; 10. The cradle of astrophysics; 11. Harlow Shapley; 12. Stellar atmospheres; 13. Spectra and luminosities; 14. Editorial experiences; 15. Visiting astronomers; 16. At the cross roads; Part III. The Dyer's Hand Subdued: 17. Turning point; 18. Prolegomena to various stars; 19. International problems; 20. End of an era; 21. Retrospect; Part IV. Reflections: 22. On being a woman; 23. Science and myth; 24. Worlds not realized; Bibliography of works by Cecilia Payne-Gaposchkin; Postlude; Index.

View of Mission Control Center celebrating conclusion of Apollo 11 mission

NASA Technical Reports Server (NTRS)

1969-01-01

Overall view of the Mission Operations Control Room in the Mission Control Center, bldg 30, Manned Spacecraft Center (MSC), at the conclusion of the Apollo 11 lunar landing mission. The television monitor shows President Richard M. Nixon greeting the Apollo 11 astronauts aboard the U.S.S. Hornet in the Pacific recovery area (40301); NASA and MSC Officials join the flight controllers in celebrating the conclusion of the Apollo 11 mission. From left foreground Dr. Maxime A. Faget, MSC Director of Engineering and Development; George S. Trimble, MSC Deputy Director; Dr. Christopher C. Kraft Jr., MSC Director fo Flight Operations; Julian Scheer (in back), Assistant Adminstrator, Offic of Public Affairs, NASA HQ.; George M. Low, Manager, Apollo Spacecraft Program, MSC; Dr. Robert R. Gilruth, MSC Director; and Charles W. Mathews, Deputy Associate Administrator, Office of Manned Space Flight, NASA HQ (40302).

Evaluation of terrestrial photogrammetric point clouds derived from thermal imagery

NASA Astrophysics Data System (ADS)

Metcalf, Jeremy P.; Olsen, Richard C.

2016-05-01

Computer vision and photogrammetric techniques have been widely applied to digital imagery producing high density 3D point clouds. Using thermal imagery as input, the same techniques can be applied to infrared data to produce point clouds in 3D space, providing surface temperature information. The work presented here is an evaluation of the accuracy of 3D reconstruction of point clouds produced using thermal imagery. An urban scene was imaged over an area at the Naval Postgraduate School, Monterey, CA, viewing from above as with an airborne system. Terrestrial thermal and RGB imagery were collected from a rooftop overlooking the site using a FLIR SC8200 MWIR camera and a Canon T1i DSLR. In order to spatially align each dataset, ground control points were placed throughout the study area using Trimble R10 GNSS receivers operating in RTK mode. Each image dataset is processed to produce a dense point cloud for 3D evaluation.

GNSS CORS hardware and software enabling new science

NASA Astrophysics Data System (ADS)

Drummond, P.

2009-12-01

GNSS CORS networks are enabling new opportunities for science and public and private sector business. This paper will explore how the newest geodetic monitoring software and GNSS receiver hardware from Trimble Navigation Ltd are enabling new science. Technology trends and science opportunities will be explored. These trends include the installation of active GNSS control, automation of observations and processing, and the advantages of multi-observable and multi-constellation observations, all performed with the use of off the shelf products and industry standard open-source data formats. Also the possibilities with moving science from an after-the-fact postprocessed model to a real-time epoch-by-epoch solution will be explored. This presentation will also discuss the combination of existing GNSS CORS networks with project specific installations used for monitoring. Experience is showing GNSS is able to provide higher resolution data than previous methods, providing new tools for science, decision makers and financial planners.

Johnston Island Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

DTIC Science & Technology

1985-01-01

BARD 1 7oi,.’. sland NAS NAS Jul 45 22 ,v 46 N 16 44 % 6 j 2 2 Sar -’ Same 23 Nov46 3u Lee47 Same Sam, am’ 243 So: - m . .Sa ,G4.. 444 Same 5.1- 4 Sam...Mar62 06Nov 62 S aime Sam, Same .. W1 07l N0,62- -Dpc62 SzL- . aea 12 Sam Same Jan 63 Feb 63 Salr,, a Sam, . m Same MarŚ Dnc rg14 Sao Same Jan 65 Jun...USAFETAC 0 O-IO5(OL Al. AMFf$0MOREi.S 0 AU OssoRl K T, . 0. WEATHER CONDITIONS ., - ’- ;’ , ’ ’ : ’ , - ’ I . - " 2 STATION . . . . . STATION NAME YRARS M NT

Bard Denali inferior vena cava filter fracture and embolization resulting in cardiac tamponade: a device failure analysis.

PubMed

Kuo, William T; Robertson, Scott W

2015-01-01

A 46-year-old woman underwent inferior vena cava filter placement before bariatric surgery and returned within 6 months for routine removal. She complained of a 1-week history of severe chest pain, and during retrieval, two fractured filter components were identified including one arm in the right ventricle. The filter body and one fragment were successfully retrieved, but the fragment in the right ventricle was refractory to percutaneous retrieval. During open-heart surgery, the fragment was found traversing through the ventricular wall resulting in cardiac tamponade. Electron microscopic fragment analysis revealed high-cycle metal fatigue indicating the filter design failed to withstand this patient's natural inferior vena cava biomechanical motions. Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.

Combination of High Rate, Real-time GNSS and Accelerometer Observations - Preliminary Results Using a Shake Table and Historic Earthquake Events.

NASA Astrophysics Data System (ADS)

Jackson, Michael; Passmore, Paul; Zimakov, Leonid; Raczka, Jared

2014-05-01

One of the fundamental requirements of an Earthquake Early Warning (EEW) system (and other mission critical applications) is to quickly detect and process the information from the strong motion event, i.e. event detection and location, magnitude estimation, and the peak ground motion estimation at the defined targeted site, thus allowing the civil protection authorities to provide pre-programmed emergency response actions: Slow down or stop rapid transit trains and high-speed trains; shutoff of gas pipelines and chemical facilities; stop elevators at the nearest floor; send alarms to hospitals, schools and other civil institutions. An important question associated with the EEW system is: can we measure displacements in real time with sufficient accuracy? Scientific GNSS networks are moving towards a model of real-time data acquisition, storage integrity, and real-time position and displacement calculations. This new paradigm allows the integration of real-time, high-rate GNSS displacement information with acceleration and velocity data to create very high-rate displacement records. The mating of these two instruments allows the creation of a new, very high-rate (200 Hz) displacement observable that has the full-scale displacement characteristics of GNSS and high-precision dynamic motions of seismic technologies. It is envisioned that these new observables can be used for earthquake early warning studies and other mission critical applications, such as volcano monitoring, building, bridge and dam monitoring systems. REF TEK a Division of Trimble has developed the integrated GNSS/Accelerograph system, model 160-09SG, which consists of REF TEK's fourth generation electronics, a 147-01 high-resolution ANSS Class A accelerometer, and Trimble GNSS receiver and antenna capable of real time, on board Precise Point Positioning (PPP) techniques with satellite clock and orbit corrections delivered to the receiver directly via L-band satellite communications. The test we conducted with the 160-09SG Recorder is focused on the characteristics of GNSS and seismic sensors in high dynamic environments, including historic earthquakes replicated on a shake table, over a range of displacements and frequencies. The main goals of the field tests are to explore the optimum integration of these sensors from a filtering perspective including simple harmonic impulses over varying frequencies and amplitudes and under the dynamic conditions of various earthquake scenarios.

Improvements in GPS precision: 10 Hz to one day

NASA Astrophysics Data System (ADS)

Choi, Kyuhong

Seeking to understand Global Positioning System (GPS) measurements and the positioning solutions in various time intervals, this dissertation improves the consistency of pseudorange measurements from different receiver types, processes 30 s interval data with optimized filtering techniques, and analyzes very-high-rate data with short arc lengths and baseline noise. The first project studies satellite-dependent biases between C/A and P1 codes. Calibrating these biases reduces the inconsistency of satellite clocks, improving the ambiguity resolution which allows for higher position precision. Receiver-dependent biases for two receivers are compared with the bias products of Center for Orbit Determination in Europe (CODE). Baseline lengths ranging up to ˜2,100km are tested with the receiver-specific biases; they resolve more phase ambiguity by 4.3% than using CODE's products. The second project analyzes 1 s and 30 s interval GPS data of the 2003 Tokachi-Oki earthquake. For 1 Hz positioning, Iterative Tropospheric Estimation (ITE) method improves vertical precision. While equalized sidereal filtering reduces noise for multipath-dominant 30--300 s periods, it can cause long-term drifts in the timeseries. A study of postseismic deformation after the Tokachi-Oki earthquake uses 30 s interval position estimations to test multiple filtering strategies to maximize precision using lower-rate data. On top of the residual stacking, estimation of a random walk constraint of sigmaDelta = 1.80 cm/ hr shows maximum noise reduction capability while retaining the real deformation signal. These techniques enhance our grasp of fault response in the aftermath of great earthquakes. The third project probes noise floor characteristics of very-high-rate (> 1 Hz) GPS data. A hybrid method, designed and tested to resolve phase biases, minimizes computational burdens while keeping the quality of ambiguity-fixed solutions. Noise characteristics are compared after an analysis of 5 and 10 Hz Ashtech MicroZ and ZFX as well as Trimble NetRS receivers. The Trimble NetRS receiver noise has a timeseries standard deviation double that of Ashtech MicroZ receivers. Also, the power spectral density function has a 0.1 Hz peak. Noise power shows white noise for the frequency range from 2 Hz and higher. Each research project assesses the methods to reduce the noises and/or biases in various time intervals. Each method considered in this dissertation will fulfill the needs for scientific applications.

Seismic Waves Generated By Oscillating Buildings: Analysis of A Snap-back Experiment

NASA Astrophysics Data System (ADS)

Gallipoli, M. R.; Mucciarelli, M.; Dolce, M.; Ponzo, F.

To explain some phenomena observed during the 1985, Mexico City earthquake, P.Y. Bard firsts hypothesised that during an earthquake vibrating buildings may transfer back to the ground a significant amount of energy. Gueguen et al. (2000) made the first measurements relative to this phenomenon studyng the energy release during a snap-back experiment on a 1:3 scale model in the EUROSEISTEST site at Volvi (Greece). During the dynamical test of a three story, base-isolated building in Rapolla (PZ- Italy), it was possible to record the vibrations induced in the ground during the release phase of the tests. Three 1-Hz, 24 bit, 3-d seismometers were positioned: in a parallel and orthogonal direction with respect to the building movement at 15 m, and in the orthogonal direction only at 50 m. The main results are: 1) at any measurement point it was possible to separate in the frequency analysis of the recorded motion the effect due to site amplification (15 Hz) from the ones due respectively to the oscillat- ing building (0.6 Hz)and the retaining wall (30 Hz); 2) the recorded signal show clear sign of the retrograde polarisation in the XZ plane typical of the Rayleigh waves 3) the amplitude of motion at 15 m distance was noticeable, reaching the one equivalent of a M=3.5 quake at the epicentral area In conclusion, we observed a phenomenon that might have important consequences for microzoning studies in dense urbanised areas. The building was isolated, and thus the energy transferred back to the ground was lesser than the one that may be caused by a standard building. Tall, massive building may transfer back to the ground a significant amount of energy, causing enhancement of duration and concentration of energy in a limited range of frequency. This phe- nomenon may be the cause of the frequently observed damage of a single building in a group of identical ones. References Gueguen Ph, Bard P.-Y. and Oliveira C. S., Experimental and numerical analysis of soil motion caused by free vibration of a building model, 2000, Bull. Seism. Soc. Am, Vol. 90.

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis.

PubMed

Polyzos, Stergios A; Goulis, Dimitrios G; Kountouras, Jannis; Mintziori, Gesthimani; Chatzis, Panagiotis; Papadakis, Efstathios; Katsikis, Ilias; Panidis, Dimitrios

2014-01-01

Insulin resistance contributes to the pathogenesis of both polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). The main aim of the present study was the evaluation of non-invasive indices of hepatic steatosis and fibrosis in PCOS women with or without metabolic syndrome (MetS). In this cross-sectional study, three non-invasive indices for hepatic steatosis [NAFLD liver fat score, lipid accumulation product (LAP) and hepatic steatosis index (HIS)] and four for fibrosis [FIB-4, aspartate aminotransferase (AST)-to-Platelet Ratio Index (APRI), body mass index (BMI)-Age-Alanine aminotransferase (ALT)-Triglycerides (BAAT) and BMI AST/ALT Ratio Diabetes (BARD)] were calculated in 314 PCOS women (77 with, 237 without MetS) and 78 controls. All steatosis indices were significantly higher in the PCOS than the control group (NAFLD liver fat score: -0.139 ± 0.117 vs. -0.976 ± 0.159, p<0.001; LAP: 43.3 ± 1.9 vs. 34.7 ± 3.1, p=0.036; HIS: 44.6 ± 0.5 vs. 42.1 ± 0.8, p=0.016). FIB-4 and BAAT [fibrosis stage (F)2-4] were higher in the PCOS group (0.480 ± 0.020 vs. 0.400 ± 0.013, p<0.001; and 15.6% vs. 5.1%, respectively), whereas APRI and BARD were not. All steatosis indices were significantly higher in PCOS women with than without MetS (NAFLD liver fat score: 1.874 ± 0.258 vs. -0.793 ± 0.099, p<0.001; LAP: 76.8 ± 4.9 vs. 33.4 ± 1.4, p<0.001; and HIS: 49.8 ± 1 vs. 43 ± 0.5, p<0.001). Of the fibrosis indices, only BAAT (F2-4: 50.6% vs. 4.2%) was higher in PCOS women with MetS. Non-invasive indices of hepatic steatosis were significantly higher in PCOS, especially in the presence of MetS, whereas indices of hepatic fibrosis yielded controversial results. Further studies are warranted to evaluate the long-term outcomes of hepatic steatosis and fibrosis indices in PCOS women.

[Subperitoneal inguinal hernioplasty by anterior approach, using a memory-ring patch. Preliminary results].

PubMed

Pélissier, E-P; Ngo, P

2006-12-01

Incidence of chronic pain is lower following laparoscopic hernioplasty than open surgery, probably due to the location of the patch in the preperitoneal space. But since laparoscopy is more demanding, the rates of complications and recurrences are higher. The aim of this study was to evaluate the results of a procedure consisting of placement of a patch, endowed with some memory of shape, provided by a thin peripheral memory ring, in the preperitoneal space, by inguinal incision, through the hernia orifice, under spinal or local anesthesia. The study was carried out in two stages. The first study consisted of evaluating the results of a prosthesis made of a polypropylene mesh endowed with a memory-ring made of a PDS cord (Ethicon SAS, 92787 Issy-les-Moulineaux). The second study evaluated the results of the Polysoft patch manufactured by Bard C degrees (Bard France, 78960 Voisins-le-Bretonneux), according to this concept. The first study involved 129 hernias operated on 126 patients of mean age 60 years (27-84). There were 3 (2.3%) benign complications. With a median follow-up of 24.5 months (12-42), 124 hernias (96%) were evaluated. There were 2 recurrences (1.6%) and 7 cases (5.6%) of chronic pain. The second series involved 150 hernias operated on 139 patients of mean age 60 years (21-94). Four (2.7%) benign complications occurred. The median length of surgery was 36 min (20-60), the median postoperative hospital stay was 1 day (0-5), the median time to return to normal activity was 3 days (0-8) and the median time off work was 18 days (1(30). The patients took paracetamol for 3 days (0-10) and the total units number was 8 (0-28). These results suggest that the method, easily reproducible, provides a low rate of complications and recurrences, as well as a low level of postoperative and chronic pain. They are worth being confirmed by a randomised comparison to the laparoscopic and Lichtenstein techniques.

Development of a Homogenous Database of Bipolar Active Regions Spanning Four Cycles

NASA Astrophysics Data System (ADS)

Munoz-Jaramillo, A.; Werginz, Z. A.; Vargas-Acosta, J. P.; DeLuca, M. D.; Vargas-Dominguez, S.; Lamb, D. A.; DeForest, C. E.; Longcope, D. W.; Martens, P.

2016-12-01

The solar cycle can be understood as a process that alternates the large-scale magnetic field of the Sun between poloidal and toroidal configurations. Although the process that transitions the solar cycle between toroidal and poloidal phases is still not fully understood, theoretical studies, and observational evidence, suggest that this process is driven by the emergence and decay of bipolar magnetic regions (BMRs) at the photosphere. Furthermore, the emergence of BMRs at the photosphere is the main driver behind solar variability and solar activity in general; making the study of their properties doubly important for heliospheric physics. However, in spite of their critical role, there is still no unified catalog of BMRs spanning multiple instruments and covering the entire period of systematic measurement of the solar magnetic field (i.e. 1975 to present).In this presentation we discuss an ongoing project to address this deficiency by applying our Bipolar Active Region Detection (BARD) code on full disk magnetograms measured by the 512 (1975-1993) and SPMG (1992-2003) instruments at the Kitt Peak Vacuum Telescope (KPVT), SOHO/MDI (1996-2011) and SDO/HMI (2010-present). First we will discuss the results of our revitalization of 512 and SPMG KPVT data, then we will discuss how our BARD code operates, and finally report the results of our cross-callibration across instruments.The corrected and improved KPVT magnetograms will be made available through the National Solar Observatory (NSO) and Virtual Solar Observatory (VSO), including updated synoptic maps produced by running the corrected KPVT magnetograms though the SOLIS pipeline. The homogeneous active region database will be made public by the end of 2017 once it has reached a satisfactory level of quality and maturity. The Figure shows all bipolar active regions present in our database (as of Aug 2016) colored according to the instrument where they were detected. The image also includes the names of the NSF-REU students in charge of the supervision of the detection algorithm and the year in which they worked on the catalog. Marker size is indicative of the total active region flux.

$${{\\bar{d}} - {\\bar{u}}}$$ Flavor Asymmetry in the Proton in Chiral Effective Field Theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salamu, Y.; Ji, Cheung-Ryong; Melnitchouk, Wally

2015-09-01

Themore » $${\\bar d - \\bar u}$$ flavor asymmetry in the proton arising from pion loops is computed using chiral effective field theory. calculation includes both nucleon and Δ intermediate states, and uses both the fully relativistic and heavy baryon frameworks. x dependence of $${\\bar d - \\bar u}$$ extracted from the Fermilab E866 Drell–Yan data can be well reproduced in terms of a single transverse momentum cutoff parameter regulating the ultraviolet behavior of the loop integrals. In addition to the distribution at x > 0, corrections to the integrated asymmetry from zero momentum contributions are computed, which arise from pion rainbow and bubble diagrams at x = 0. These have not been accounted for in previous analyses, and can make important contributions to the lowest moment of $${\\bar d-\\bar u}$$ .« less

Olaparib in Treating Patients With Metastatic or Advanced Urothelial Cancer With DNA-Repair Defects

ClinicalTrials.gov

2018-06-14

Abnormal DNA Repair; ATM Gene Mutation; ATR Gene Mutation; BAP1 Gene Mutation; BARD1 Gene Mutation; BLM Gene Mutation; BRCA1 Gene Mutation; BRCA2 Gene Mutation; BRIP1 Gene Mutation; CHEK1 Gene Mutation; CHEK2 Gene Mutation; FANCC Gene Mutation; FANCD2 Gene Mutation; FANCE Gene Mutation; FANCF Gene Mutation; MEN1 Gene Mutation; Metastatic Urothelial Carcinoma; MLH1 Gene Mutation; MSH2 Gene Mutation; MSH6 Gene Mutation; MUTYH Gene Mutation; NPM1 Gene Mutation; PALB2 Gene Mutation; PMS2 Gene Mutation; POLD1 Gene Mutation; POLE Gene Mutation; PRKDC Gene Mutation; RAD50 Gene Mutation; RAD51 Gene Mutation; SMARCB1 Gene Mutation; Stage III Bladder Urothelial Carcinoma AJCC v6 and v7; Stage IV Bladder Urothelial Carcinoma AJCC v7; STK11 Gene Mutation; Urothelial Carcinoma

Stars on Local Time: A Personal Almanac

NASA Astrophysics Data System (ADS)

Gottlieb-Roberts, M.

2016-01-01

First presented at INSAP VIII, the artwork A Personal Almanac is my interpretation of the familiar seasons-of-life allegory. The booklet's eight pairs of seasonal pages— spring equinox through the cross-quarter Groundhog Day—portray a life in the decades from the 1940s to the 2010s under the stars of rural Georgia, France, Miami, West Africa and the other places I have lived. A Personal Almanac is included in the art book A Durable Tale, the illustrated story of my thirty-year search in the Southeast United States and in West Africa for living memories of old star almanacs. In that odyssey I uncovered some very deep roots for an oral literature of the African desert, the nomadic bard's star story that I believe inspired creation of the first nine tablets of the standard version Babylonian Gilgamesh.

Comparison of atmospheric water vapour content with GNSS, Radiosonde, Microwave radiometer, and Lidar

NASA Astrophysics Data System (ADS)

Sohn, D.; Park, K.

2012-12-01

The increased amount of saturated water vapor due to the Earth's temperature rise frequently causes abnormal meteorological phenomena such as local severe rainfall in Korea. The National Institute of Meteorological Research of Korea Meteorological Administration (KMA) conducted observation experiments using a variety of water-vapor measuring equipments to improve the accuracy of weather forecasts and accurately measure the precipitable water vapor in the atmosphere. Equipments used were GNSS, water vapor radiometers (WVR), radiosonde, and LiDAR. For GNSS measurements we used two receivers that can collect not only GPS but also GLONASS signals: Trimble NetR5 and Septentrio PolaRx4. The two WVR makers are Raidometrics and RPG. For radiosonde observations, KMA launched Vaisala GPSondes every 6 hours during the experiment period. The LiDAR system was made locally by Hanbat University in Daejeon. Thus, we could obtain collocation experiment results from 6 different kinds of water vapor measurement and analyze the characteristics of each device.

First report of parasites from pinnipeds in the Galapagos Islands, Ecuador, with a description of a new species of Philophthalmus (Digenea: Philophthalmidae).

PubMed

Dailey, M; Ellin, R; Parás, A

2005-06-01

A new species of digenetic trematode and 2 species of ectoparasites from Zalophus wollebaeki Silvertsen, 1953 (Carnivora: Otariidae) in the Galapagos Islands, Ecuador, are reported. These include an eye fluke of Philophthalmus Looss, 1899 (Echinostomata: Philophthalmidae) as well as, to our knowledge, the first report of Antarctophthirus microchir (Trouessart and Neumann, 1888) Enderlein, 1906 (Arthropoda: Anoplura) and Orthohalarachne diminuata (Doetschman, 1944) Newell, 1947 (Arthropoda: Acarina) from this host and location. Philophthalmus zalophi n. sp. differs from the 4 other marine species of Philophthalmus (P. andersoni Dronen and Penner, 1975; P. burrili Howell and Bearup, 1967; P. hegeneri Penner and Fried, 1963; and P. larsoni Penner and Trimble, 1970) by its mammalian host, large body size, lack of tegumental spines, posterior length of seminal vesicle, placement of genital pore, size ratio of oral sucker to acetabulum, shape and size of testes, and size ratio of ovary to testis.

Perception of the minority's collective identity and voting behavior: the case of the Palestinians in Israel.

PubMed

Suleiman, Ramzi

2002-12-01

The author investigated how Palestinian (n = 130) and Jewish (n = 153) Israeli university students perceived the collective identity of the Palestinian minority in Israel. The Palestinian and Jewish respondents perceived the "identity space" of the minority as linear, or bipolar, with 1 pole defined by the national (Palestinian) identity and the other defined by the civic (Israeli) label. The Palestinian respondents defined their collective identity in national (Palestinian, Arab) and integrative (Israeli-Palestinian) terms; the Jewish respondents perceived the minority's identity as integrative (Israeli-Palestinian). Different political outlooks among Palestinian respondents were related to their identification with the civic (Israeli) identity but not to their identification with the national (Palestinian) identity. In contrast, different political outlooks among Jewish respondents were related to their inclusion, or exclusion, of the national (Palestinian) component in their definition of the minority's identity. Implications of the results are discussed in terms of a minority acculturation model (J. Berry, J. Trimble, & E. Olmedo, 1986).

AUGUSTO'S Sundial: Image-Based Modeling for Reverse Engeneering Purposes

NASA Astrophysics Data System (ADS)

Baiocchi, V.; Barbarella, M.; Del Pizzo, S.; Giannone, F.; Troisi, S.; Piccaro, C.; Marcantonio, D.

2017-02-01

A photogrammetric survey of a unique archaeological site is reported in this paper. The survey was performed using both a panoramic image-based solution and by classical procedure. The panoramic image-based solution was carried out employing a commercial solution: the Trimble V10 Imaging Rover (IR). Such instrument is an integrated cameras system that captures 360 degrees digital panoramas, composed of 12 images, with a single push. The direct comparison of the point clouds obtained with traditional photogrammetric procedure and V10 stations, using the same GCP coordinates has been carried out in Cloud Compare, open source software that can provide the comparison between two point clouds supplied by all the main statistical data. The site is a portion of the dial plate of the "Horologium Augusti" inaugurated in 9 B.C.E. in the area of Campo Marzio and still present intact in the same position, in a cellar of a building in Rome, around 7 meter below the present ground level.

Do humans ape? Or do apes human? Imitation and intention in humans (Homo sapiens) and other animals.

PubMed

Horowitz, Alexandra C

2003-09-01

A. Whiten, D. M. Custance, J.-C. Gomez, P. Teixidor, and K. A. Bard (1996) tested chimpanzees' (Pan troglodytes) and human children's (Homo sapiens) skills at imitation with a 2-action test on an "artificial fruit." Chimpanzees imitated to a restricted degree; children were more thoroughly imitative. Such results prompted some to assert that the difference in imitation indicates a difference in the subjects' understanding of the intentions of the demonstrator (M. Tomasello, 1996). In this experiment, 37 adult human subjects were tested with the artificial fruit. Far from being perfect imitators, the adults were less imitative than the children. These results cast doubt on the inference from imitative performance to an ability to understand others' intentions. The results also demonstrate how any test of imitation requires a control group and attention to the level of behavioral analysis. Copyright 2003 APA, all rights reserved

Spin Filtering Studies at COSY and AD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nass, Alexander

2009-08-04

The high physics potential of experiments with stored high-energy polarized antiprotons led to the proposal of PAX (Polarized Antiproton eXperiment) for the High Energy Storage Ring (HESR) of the FAIR at GSI (Darmstadt/Germany). It is proposed to polarize a stored antiproton beam by means of spin filtering with a polarized H (D) gas target. The feasibility of spin filtering has been demonstrated in the FILTEX experiment. The current interpretation foresees a self-cancellation of the electron contribution to the filtering process and only the hadronic contribution is effective. Several experimental studies with protons (at COSY/Juelich) as well as antiprotons (at AD/CERN)more » will be carried out to test the principle and measure p-barp-vector and p-bard-vector cross sections. A polarized internal gas target (PIT) with surrounding Silicon detectors immersed into a low-beta section has to be set up.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beaumier, Michael J.

This thesis discusses the process of extracting the longitudinal asymmetry, Amore » $$W±\\atop{L}$$ describing W → μ production in forward kinematic regimes. This asymmetry is used to constrain our understanding of the polarized parton distribution functions characterizing $$\\bar{u}$$ and $$\\bar{d}$$ sea quarks in the proton. This asymmetry will be used to constrain the overall contribution of the sea-quarks to the total proton spin. The asymmetry is evaluated over the pseudorapidity range of the PHENIX Muon Arms, 2.1 < |η| 2.6, for longitudinally polarized proton-proton collisions at 510 GeV √s. In particular, I will discuss the statistical methods used to characterize real muonic W decays and the various background processes is presented, including a discussion of likelihood event selection and the Extended Unbinned Maximum Likelihood t. These statistical methods serve estimate the yields of W muonic decays, which are used to calculate the longitudinal asymmetry.« less

A parapraxis in Hamlet. A note on the aesthetic genius of William Shakespeare.

PubMed

Mahon, E

1998-01-01

Shakespeare has placed a parapraxis in Hamlet's mouth in the soliloquy in Act I. Hamlet says, "But two months dead, nay not so much not two." The slip attributed to Hamlet is of course no slip at all when seen as an aesthetic contrivance of the bard's to suggest the tension between warring aspects of Hamlet's psychology. I argue that Shakespeare's artistic methodology, his aesthetic sleight of hand, so to speak, which layers this complex drama with meanings concealing other meanings, supports Freud's notion that an unconscious latent oedipal drama underlies the whole manifest content, imbuing it with subtle but substantial dramatic tension. The slip of the tongue is not only a window into the unconscious of Hamlet that sheds light on the hero's Oedipus complex and the complexities of his attempted resolutions, it is also an example of Shakespeare's aesthetic subtlety at its most refined.

Biliary atresia: unity in diversity.

PubMed

Petersen, Claus

2017-12-01

Biliary atresia (BA) is a rare disease of unknown origin and unsatisfying outcome. Single, multicenter and national evaluations of epidemiological and outcome data on BA have been periodically published over the course of decades. However, the diversity of the registered parameters and outcome measures impede comparability and cumulative analysis of these very worthwhile studies. Taking into account the fact that BA is a good example of translational research and transition of patients from pediatric surgery and hepatology to transplant surgery and hepatology in general, the interdisciplinary community should make every effort to develop a common platform upon which further activities are conducted. Extending this topic to BA-related diseases might increase the acceptance of research studies and enhance the effectiveness of any recommendations outlined therein. The use of the Internet-based communication platform and registry on http://www.bard-online.com represents the first step in this direction, and the database should be viewed as a helpful tool that guides further activities.

Amplitude analysis of four-body decays using a massively-parallel fitting framework

NASA Astrophysics Data System (ADS)

Hasse, C.; Albrecht, J.; Alves, A. A., Jr.; d'Argent, P.; Evans, T. D.; Rademacker, J.; Sokoloff, M. D.

2017-10-01

The GooFit Framework is designed to perform maximum-likelihood fits for arbitrary functions on various parallel back ends, for example a GPU. We present an extension to GooFit which adds the functionality to perform time-dependent amplitude analyses of pseudoscalar mesons decaying into four pseudoscalar final states. Benchmarks of this functionality show a significant performance increase when utilizing a GPU compared to a CPU. Furthermore, this extension is employed to study the sensitivity on the {{{D}}}0-{\\bar{{{D}}}}0 mixing parameters x and y in a time-dependent amplitude analysis of the decay D0 → K+π-π+π-. Studying a sample of 50 000 events and setting the central values to the world average of x = (0.49 ± 0.15)% and y = (0.61 ± 0.08)%, the statistical sensitivities of x and y are determined to be σ(x) = 0.019 % and σ(y) = 0.019 %.

Five scientists at Johns Hopkins in the modern evolution of neuroscience.

PubMed

Harrison, T S

2000-08-01

Neuroscience's evolution at Johns Hopkins, from neurophysiology to the new field of neurobiology, though unplanned, was rapid and important. Beginning in 1933 when Philip Bard became professor of physiology at Johns Hopkins, members of his department concentrated initially on neuroanatomical control of placing reactions and sexual activity. Vernon Mountcastle, extending available techniques, discovered vertical somato-sensory columns in the 1950's. Stephen Kuffler, who arrived at Hopkins in 1947, was a pioneer in single unit microelectrode recording techniques. He soon attracted scientists from all over the world to his laboratory. Among them, Torsten Wiesel and David Hubel discovered vertical neuronal columns in the visual cortex. During several decades at Johns Hopkins, these five scientists set extremely high scientific standards and established a climate of inquiry in which ideas were shared and young scientists encouraged. They contributed significantly to the emerging discipline of neuroscience.

Field Installation and Real-Time Data Processing of the New Integrated SeismoGeodetic System with Real-Time Acceleration and Displacement Measurements for Earthquake Characterization Based on High-Rate Seismic and GPS Data

NASA Astrophysics Data System (ADS)

Zimakov, Leonid; Jackson, Michael; Passmore, Paul; Raczka, Jared; Alvarez, Marcos; Barrientos, Sergio

2015-04-01

We will discuss and show the results obtained from an integrated SeismoGeodetic System, model SG160-09, installed in the Chilean National Network. The SG160-09 provides the user high rate GNSS and accelerometer data, full epoch-by-epoch measurement integrity and, using the Trimble Pivot™ SeismoGeodetic App, the ability to create combined GNSS and accelerometer high-rate (200Hz) displacement time series in real-time. The SG160-09 combines seismic recording with GNSS geodetic measurement in a single compact, ruggedized package. The system includes a low-power, 220-channel GNSS receiver powered by the latest Trimble-precise Maxwell™6 technology and supports tracking GPS, GLONASS and Galileo signals. The receiver incorporates on-board GNSS point positioning using Real-Time Precise Point Positioning (PPP) technology with satellite clock and orbit corrections delivered over IP networks. The seismic recording element includes an ANSS Class A, force balance triaxial accelerometer with the latest, low power, 24-bit A/D converter, which produces high-resolution seismic data. The SG160-09 processor acquires and packetizes both seismic and geodetic data and transmits it to the central station using an advanced, error-correction protocol with back fill capability providing data integrity between the field and the processing center. The SG160-09 has been installed in the seismic station close to the area of the Iquique earthquake of April 1, 2014, in northern Chile, a seismically prone area at the current time. The hardware includes the SG160-09 system, external Zephyr Geodetic-2 GNSS antenna, and high-speed Internet communication media. Both acceleration and displacement data was transmitted in real-time to the National Seismological Center in Santiago for real-time data processing using Earthworm / Early Bird software. Command/Control of the field station and real-time GNSS position correction are provided via the Pivot software suite. Data from the SG160-09 system was used for seismic event characterization along with data from traditional stand-alone broadband seismic and geodetic stations installed in the network. Our presentation will focus on the key improvements of the network installation with the SG160-09 system, rapid data transmission, and real-time data processing for strong seismic events and aftershock characterization as well as advanced features of the SG160-09 for Earthquake and Tsunami Early Warning system.

Starch characteristics of transgenic wheat (Triticum aestivum L.) overexpressing the Dx5 high molecular weight glutenin subunit are substantially equivalent to those in nonmodified wheat.

PubMed

Beckles, Diane M; Tananuwong, Kanitha; Shoemaker, Charles F

2012-04-01

The effects of engineering higher levels of the High Molecular Weight Glutenin Dx5 subunit on starch characteristics in transgenic wheat (Triticum aestivum L.) grain were evaluated. This is important because of the interrelationship between starch and protein accumulation in grain, the strong biotechnological interest in modulating Dx5 levels and the increasing likelihood that transgenic wheat will be commercialized in the U.S. Unintended effects of Dx5 overexpression on starch could affect wheat marketability and therefore should be examined. Two controls with native levels of Dx5 were used: (i) the nontransformed Bobwhite cultivar, and (ii) a transgenic line (Bar-D) expressing a herbicide resistant (bar) gene, and they were compared with 2 transgenic lines (Dx5G and Dx5J) containing bar and additional copies of Dx5. There were few changes between Bar-D and Dx5G compared to Bobwhite. However, Dx5J, the line with the highest Dx5 protein (×3.5) accumulated 140% more hexose, 25% less starch and the starch had a higher frequency of longer amylopectin chains. These differences were not of sufficient magnitude to influence starch functionality, because granule morphology, crystallinity, amylose-to-amylopectin ratio, and the enthalpy of starch gelatinization and the amylose-lipid complex melting were similar to the control (P > 0.05). This overall similarity was borne out by Partial Least Squares-Discriminant Function Analysis, which could not distinguish among genotypes. Collectively our data imply that higher Dx5 can affect starch accumulation and some aspects of starch molecular structure but that the starches of the Dx5 transgenic wheat lines are substantially equivalent to the controls. Transgenic manipulation of biochemical pathways is an effective way to enhance food sensory quality, but it can also lead to unintended effects. These spurious changes are a concern to Government Regulatory Agencies and to those Industries that market the product. In this study we examined if making "specific" changes to the composition of gluten proteins in wheat seeds would simultaneously alter starch, as their synthesis is interrelated and the molecular structure of both determine flour functionality. This information may be used to address issues of "substantial equivalence" and to inform Industrial End-Users of possible changes in product performance. © 2012 Institute of Food Technologists®

The San Juan Canyon, southeastern Utah: A geographic and hydrographic reconnaissance

USGS Publications Warehouse

Miser, Hugh D.

1924-01-01

This report, which describes the San Juan Canyon, San Juan River and the tributary streams and the geography and to some extent the geology of the region, presents information obtained by me during the descent of the river with the Trimble party in 1921. The exploration of the canyon, which was financed jointly by the United States Geological Survey and the Southern California Edison Co., had as its primary object the mapping and study of the San Juan in connection with proposed power and storage projects along this and Colorado rivers.1 The exploration party was headed by K. W. Thimble, topographic engineer of the United States Geological Survey. Other members of the party were Robert N. Allen, Los Angeles, Calif., recorder; H. E. Blake, jr., Monticello, Utah, and Hugh Hyde, Salt Lake City, Utah, rodmen; Bert Loper, Green River, Utah, boatman; Heber Christensen, Moab, Utah, cook; and H. D. Miser, geologist. Wesley Oliver, of Mexican Hat, Utah, served as packer for the party and brought mail and provisions by pack train twice a month to specified accessible places west of Goodridge.

Methods for monitoring the effects of grazing management on bank erosion and channel morphology, Fever River, Pioneer Farm, Wisconsin, 2004

USGS Publications Warehouse

Peppler, Marie C.; Fitzpatrick, Faith A.

2005-01-01

Bank erosion is a natural process that occurs in meandering streams (Leopold and others, 1964); however, in the Midwestern United States, historical and present agricultural activities in uplands, riparian areas, and channels have increased erosion (Waters, 1995; Lyons and others, 2000; Simon and Rinaldi, 2000; and Knox, 2001). Reducing streambank erosion is important because sediment carried by streams has adverse environmental effects; for example, sediment carried by streams is a major source of phosphorus (Waters, 1995). Continuous cattle grazing in riparian areas may increase local erosion processes in a meandering stream by removal or trampling of bank vegetation, which in turn affects channel morphology, water chemistry, and fish and aquatic-insect habitat (Kauffman and Krueger, 1984; Fitch and Adams, 1998). However, studies of livestock exclusion from riparian corridors have shown mixed results in reducing bank erosion (Trimble, 1994; Sarr, 2002). Some studies have shown reduced bank erosion after row-cropped or continuously grazed riparian areas are converted to managed grazing (see inset box) (Lyons and others, 2000; Sovell and others, 2000; and Zaimes and others, 2004).

Use of NTRIP for optimizing the decoding algorithm for real-time data streams.

PubMed

He, Zhanke; Tang, Wenda; Yang, Xuhai; Wang, Liming; Liu, Jihua

2014-10-10

As a network transmission protocol, Networked Transport of RTCM via Internet Protocol (NTRIP) is widely used in GPS and Global Orbiting Navigational Satellite System (GLONASS) Augmentation systems, such as Continuous Operational Reference System (CORS), Wide Area Augmentation System (WAAS) and Satellite Based Augmentation Systems (SBAS). With the deployment of BeiDou Navigation Satellite system(BDS) to serve the Asia-Pacific region, there are increasing needs for ground monitoring of the BeiDou Navigation Satellite system and the development of the high-precision real-time BeiDou products. This paper aims to optimize the decoding algorithm of NTRIP Client data streams and the user authentication strategies of the NTRIP Caster based on NTRIP. The proposed method greatly enhances the handling efficiency and significantly reduces the data transmission delay compared with the Federal Agency for Cartography and Geodesy (BKG) NTRIP. Meanwhile, a transcoding method is proposed to facilitate the data transformation from the BINary EXchange (BINEX) format to the RTCM format. The transformation scheme thus solves the problem of handing real-time data streams from Trimble receivers in the BeiDou Navigation Satellite System indigenously developed by China.

gDNA enrichment by a transposase-based technology for NGS analysis of the whole sequence of BRCA1, BRCA2, and 9 genes involved in DNA damage repair.

PubMed

Chevrier, Sandy; Boidot, Romain

2014-10-06

The widespread use of Next Generation Sequencing has opened up new avenues for cancer research and diagnosis. NGS will bring huge amounts of new data on cancer, and especially cancer genetics. Current knowledge and future discoveries will make it necessary to study a huge number of genes that could be involved in a genetic predisposition to cancer. In this regard, we developed a Nextera design to study 11 complete genes involved in DNA damage repair. This protocol was developed to safely study 11 genes (ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, PALB2, RAD50, RAD51C, RAD80, and TP53) from promoter to 3'-UTR in 24 patients simultaneously. This protocol, based on transposase technology and gDNA enrichment, gives a great advantage in terms of time for the genetic diagnosis thanks to sample multiplexing. This protocol can be safely used with blood gDNA.

[The Predictive Factors of Stent Failure in the Treatment of Malignant Extrinsc Ureteral Obstruction Using Internal Ureteral Stents].

PubMed

Matsuura, Hiroshi; Arase, Shigeki; Hori, Yasuhide; Tochigi, Hiromi

2017-12-01

In this study, we retrospectively reviewed the experiences at our single institute in the treatment of malignant extrinsic ureteral obstruction (MUO) using ureteral stents to investigate the clinical outcomes and the predictive factors of stent failure. In 52 ureters of 38 patients who had radiologically significant hydronephrosis due to MUO, internal ureteral stents (The BARD(R) INLAY(TM) ureteral stent set) were inserted. The median follow-up interval after the initial stent insertion was 124.5 days (4-1,120). Stent failure occurred in 8 ureters (15.4%) of the 7 patients. The median interval from the first stent insertion to stent failure was 88 days (1-468). A Cox regression multivariate analysis showed that the significant predictors of stent failure were bladder invasion. Based on the possibility of stent failure, the adaptation of the internal ureteral stent placement should be considered especially in a patient with MUO combined with bladder invasion.

Greenhouse effect and ice ages: historical perspective

NASA Astrophysics Data System (ADS)

Bard, Edouard

2004-06-01

This article provides a brief historical perspective on the first scientific research on the greenhouse effect and glaciations. While these two aspects of our climate can be investigated separately, naturalists, physicists and chemists during the 19th century were interested jointly in both issues, as well as the possible relationship between them. The contributions of famous pioneers are mentioned, ranging from scholars with encyclopaedic knowledge such as Horace-Bénédict de Saussure, to modern scientists like Svante Arrhenius, who was first to predict global warming as a consequence of using fossil fuels. Despite fragmentary observations, these pioneers had prophetic insights. Indeed, the main fundamental concepts used nowadays have been developed during the 19th century. However, we must wait until the second half of the 20th century to see a true revolution of investigative techniques in the Earth Sciences, enabling full access to previously unknown components of the climate system, such as deep oceans and the interior of the polar ice caps. To cite this article: E. Bard, C. R. Geoscience 336 (2004).

The {{\\rm{D}}\\bar{{\\rm{D}}}}^{{\\rm{* }}} interaction with isospin zero in an extended hidden gauge symmetry approach

NASA Astrophysics Data System (ADS)

Sun, Bao-Xi; Wan, Da-Ming; Zhao, Si-Yu

2018-05-01

The {{{D}}\\bar{{{D}}}}{{* }} interaction via a ρ or ω exchange is constructed within an extended hidden gauge symmetry approach, where the strange quark is replaced by the charm quark in the SU(3) flavor space. With this {{{D}}\\bar{{{D}}}}{{* }} interaction, a bound state slightly lower than the {{{D}}\\bar{{{D}}}}{{* }} threshold is generated dynamically in the isospin zero sector by solving the Bethe-Salpeter equation in the coupled-channel approximation, which might correspond to the X(3872) particle announced by many collaborations. This formulism is also used to study the {{{B}}\\bar{{{B}}}}{{* }} interaction, and a {{{B}}\\bar{{{B}}}}{{* }} bound state with isospin zero is generated dynamically, which has no counterpart listed in the review of the Particle Data Group. Furthermore, the one-pion exchange between the D meson and the {\\bar{{{D}}}}{{* }} is analyzed precisely, and we do not think the one-pion exchange potential need be considered when the Bethe-Salpeter equation is solved.

The healing hand in literature: Shakespeare and surgery.

PubMed

Fu, K TL

1998-03-01

The interplay between surgery and dramatic literature in the plays of Shakespeare is reviewed. This review attempts to explore medical references in Shakespeare's works and to analyse the medical and social background of his time. Caution should be taken in interpreting Shakespeare's works through a modern medical view; diseases and their therapy are used metaphorically as a means to an end in the Bard's masterly hands. Shakespeare's medical knowledge may be accounted for by his avid reading of contemporary medical texts, from primary or secondary sources; an astute sense of observation of London's medical practitioners---bona fide or otherwise---and their activities and patients; and a medical connection by way of his son-in-law, Dr John Hall. It should be remembered that nothing in Nature stands alone; but every art and science has a relation to some other art or science, that it requires us to have a knowledge of those others, as this connexion takes place, to enable us to become perfect in that which engages our particular attention. John Hunter (1728-93)

A Novel Germline Mutation in BRCA1 Causes Exon 20 Skipping in a Korean Family with a History of Breast Cancer.

PubMed

Yoon, Kyong-Ah; Kong, Sun-Young; Lee, Eun Ji; Cho, Jeong Nam; Chang, Suhwan; Lee, Eun Sook

2017-09-01

Germline mutations in the BRCA1 and BRCA2 genes are strong genetic factors for predispositions to breast, ovarian, and other related cancers. This report describes a family with a history of breast and ovarian cancers that harbored a novel BRCA1 germline mutation. A single nucleotide deletion in intron 20, namely c.5332+4delA, was detected in a 43-year-old patient with breast cancer. This mutation led to the skipping of exon 20, which in turn resulted in the production of a truncated BRCA1 protein that was 1773 amino acids in length. The mother of the proband had died due to ovarian cancer and had harbored the same germline mutation. Ectopically expressed mutant BRCA1 protein interacted with the BARD1 protein, but showed a reduced transcriptional function, as demonstrated by the expression of cyclin B1 . This novel germline mutation in the BRCA1 gene caused familial breast and ovarian cancers.

The DNA damage response activates HPV16 late gene expression at the level of RNA processing.

PubMed

Nilsson, Kersti; Wu, Chengjun; Kajitani, Naoko; Yu, Haoran; Tsimtsirakis, Efthymios; Gong, Lijing; Winquist, Ellenor B; Glahder, Jacob; Ekblad, Lars; Wennerberg, Johan; Schwartz, Stefan

2018-06-01

We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal that resulted in read-through into the late region of HPV16. This was followed by activation of the exclusively late, HPV16 splice sites SD3632 and SA5639 and production of spliced late L1 mRNAs. Altered HPV16 mRNA processing was paralleled by increased association of phosphorylated BRCA1, BARD1, BCLAF1 and TRAP150 with HPV16 DNA, and increased association of RNA processing factors U2AF65 and hnRNP C with HPV16 mRNAs. These RNA processing factors inhibited HPV16 early polyadenylation and enhanced HPV16 late mRNA splicing, thereby activating HPV16 late gene expression.

Audience design affects acoustic reduction via production facilitation.

PubMed

Arnold, Jennifer E; Kahn, Jason M; Pancani, Giulia C

2012-06-01

In this article, we examine the hypothesis that acoustic variation (e.g., reduced vs. prominent forms) results from audience design. Bard et al. (Journal of Memory and Language 42:1-22, 2000) have argued that acoustic prominence is unaffected by the speaker's estimate of addressee knowledge, using paradigms that contrast speaker and addressee knowledge. This question was tested in a novel paradigm, focusing on the effects of addressees' feedback about their understanding of the speaker's intended message. Speakers gave instructions to addressees about where to place objects (e.g., the teapot goes on red). The addressee either anticipated the object, by picking it up before the instruction, or waited for the instruction. For anticipating addressees, speakers began speaking more quickly and pronounced the word the with shorter duration, demonstrating effects of audience design. However, no effects appeared on the head noun (e.g., teapot), as measured by duration, amplitude, and perceived intelligibility. These results are consistent with a mechanism in which evidence about addressee understanding facilitates production processes, as opposed to triggering particular acoustic forms.

The Inventory Of High Objects Applying Laser Scanning, Focus On The Cataloguing A Reinforced Concrete Industrial Chimney

NASA Astrophysics Data System (ADS)

Gawałkiewicz, Rafał

2015-12-01

There are many surveying methods to measure the inclination of a chimney with the use of classical protractor instruments (Theo 010A/B, T2 Wild), electronic theodolites (TC2002 Wild-Leica), electronic total stations, including mirrorless ones, allowing to define indirectly the course of the construction's axis on the selected observation levels. The methods are the following: indentations, direct projection, double-edged method, polar method with the option of mirrorless measurement. At the moment a very practical and quick measurement technology, significantly eliminating the influence of human errors on the observation results, is laser scanning. The article presents the results of the scanning of 120-metres high reinforced concrete industrial chimney of the Cement Plant "Ożarów", with the application of modern scanning total station VX Spatial Station by Trimble, as an alternative to the methods applied so far. The advantage of scanning is the possibility to obtain a point cloud, which, apart from the information on the course of the chimney axis in the space, provides detail information on the real shape and deformations of the coating of the object's core.

Meteorology and GNSS? What is the benefit?

NASA Astrophysics Data System (ADS)

Drummond, P.; Grünig, S.

2010-12-01

Due to the strong correlation between water vapor in the atmosphere and GNSS tropospheric propagation delays, we can estimate the Integrated Precipitable Water Vapor (IPWV) in the atmosphere through GNSS measurements. This parameter is crucial for meteorologists as the water content in the atmosphere is a key parameter in the weather models. The Total Electron Content (TEC) in the ionosphere has a huge impact on the ionospheric propagation delay in GNSS signals. By computing the ionospheric delay from GNSS measurements it is possible to predict the TEC which is an excellent indicator for ionospheric activity. The benefit is that we can estimate the influence on the RTK performance from TEC values. The atmospheric feature in the Trimble Atmosphere App (as well as in VRSNet software) allows computing both IPWV and TEC values from a CORS network. IPWV is computed using surface meteorological data such as temperature and pressure as well as radiosonde data. The results are shown in a table like form as well as in numerous graphical forms such as contour and surface plots, station and condition charts. The computed values can be animated in a movie over the last 24 hours.

Using Parameters of Dynamic Pulse Function for 3d Modeling in LOD3 Based on Random Textures

NASA Astrophysics Data System (ADS)

Alizadehashrafi, B.

2015-12-01

The pulse function (PF) is a technique based on procedural preprocessing system to generate a computerized virtual photo of the façade with in a fixed size square(Alizadehashrafi et al., 2009, Musliman et al., 2010). Dynamic Pulse Function (DPF) is an enhanced version of PF which can create the final photo, proportional to real geometry. This can avoid distortion while projecting the computerized photo on the generated 3D model(Alizadehashrafi and Rahman, 2013). The challenging issue that might be handled for having 3D model in LoD3 rather than LOD2, is the final aim that have been achieved in this paper. In the technique based DPF the geometries of the windows and doors are saved in an XML file schema which does not have any connections with the 3D model in LoD2 and CityGML format. In this research the parameters of Dynamic Pulse Functions are utilized via Ruby programming language in SketchUp Trimble to generate (exact position and deepness) the windows and doors automatically in LoD3 based on the same concept of DPF. The advantage of this technique is automatic generation of huge number of similar geometries e.g. windows by utilizing parameters of DPF along with defining entities and window layers. In case of converting the SKP file to CityGML via FME software or CityGML plugins the 3D model contains the semantic database about the entities and window layers which can connect the CityGML to MySQL(Alizadehashrafi and Baig, 2014). The concept behind DPF, is to use logical operations to project the texture on the background image which is dynamically proportional to real geometry. The process of projection is based on two vertical and horizontal dynamic pulses starting from upper-left corner of the background wall in down and right directions respectively based on image coordinate system. The logical one/zero on the intersections of two vertical and horizontal dynamic pulses projects/does not project the texture on the background image. It is possible to define priority for each layer. For instance the priority of the door layer can be higher than window layer which means that window texture cannot be projected on the door layer. Orthogonal and rectified perpendicular symmetric photos of the 3D objects that are proportional to the real façade geometry must be utilized for the generation of the output frame for DPF. The DPF produces very high quality and small data size of output image files in quite smaller dimension compare with the photorealistic texturing method. The disadvantage of DPF is its preprocessing method to generate output image file rather than online processing to generate the texture within the 3D environment such as CityGML. Furthermore the result of DPF can be utilized for 3D model in LOD2 rather than LOD3. In the current work the random textures of the window layers are created based on parameters of DPF within Ruby console of SketchUp Trimble to generate the deeper geometries of the windows and their exact position on the façade automatically along with random textures to increase Level of Realism (LoR)(Scarpino, 2010). As the output frame in DPF is proportional to real geometry (height and width of the façade) it is possible to query the XML database and convert them to units such as meter automatically. In this technique, the perpendicular terrestrial photo from the façade is rectified by employing projective transformation based on the frame which is in constrain proportion to real geometry. The rectified photos which are not suitable for texturing but necessary for measuring, can be resized in constrain proportion to real geometry before measuring process. Height and width of windows, doors, horizontal and vertical distance between windows from upper left corner of the photo dimensions of doors and windows are parameters that should be measured to run the program as a plugins in SketchUp Trimble. The system can use these parameters and texture file names and file paths to create the façade semi-automatically. To avoid leaning geometry the textures of windows, doors and etc, should be cropped and rectified from perpendicular photos, so that they can be used in the program to create the whole façade along with its geometries. Texture enhancement should be done in advance such as removing disturbing objects, exposure setting, left-right up-down transformation, and so on. In fact, the quality, small data size, scale and semantic database for each façade are the prominent advantages of this method.

Experimental evaluation of ALS point cloud ground extraction over different land cover in the Malopolska Province

NASA Astrophysics Data System (ADS)

Korzeniowska, Karolina; Mandlburger, Gottfried; Klimczyk, Agata

2013-04-01

The paper presents an evaluation of different terrain point extraction algorithms for Airborne Laser Scanning (ALS) point clouds. The research area covers eight test sites in the Małopolska Province (Poland) with varying point density between 3-15points/m² and surface as well as land cover characteristics. In this paper the existing implementations of algorithms were considered. Approaches based on mathematical morphology, progressive densification, robust surface interpolation and segmentation were compared. From the group of morphological filters, the Progressive Morphological Filter (PMF) proposed by Zhang K. et al. (2003) in LIS software was evaluated. From the progressive densification filter methods developed by Axelsson P. (2000) the Martin Isenburg's implementation in LAStools software (LAStools, 2012) was chosen. The third group of methods are surface-based filters. In this study, we used the hierarchic robust interpolation approach by Kraus K., Pfeifer N. (1998) as implemented in SCOP++ (Trimble, 2012). The fourth group of methods works on segmentation. From this filtering concept the segmentation algorithm available in LIS was tested (Wichmann V., 2012). The main aim in executing the automatic classification for ground extraction was operating in default mode or with default parameters which were selected by the developers of the algorithms. It was assumed that the default settings were equivalent to the parameters on which the best results can be achieved. In case it was not possible to apply an algorithm in default mode, a combination of the available and most crucial parameters for ground extraction were selected. As a result of these analyses, several output LAS files with different ground classification were achieved. The results were described on the basis of qualitative and quantitative analyses, both being in a formal description. The classification differences were verified on point cloud data. Qualitative verification of ground extraction was made on the basis of a visual inspection of the results (Sithole G., Vosselman G., 2004; Meng X. et al., 2010). The results of these analyses were described as a graph using weighted assumption. The quantitative analyses were evaluated on a basis of Type I, Type II and Total errors (Sithole G., Vosselman G., 2003). The achieved results show that the analysed algorithms yield different classification accuracies depending on the landscape and land cover. The simplest terrain for ground extraction was flat rural area with sparse vegetation. The most difficult were mountainous areas with very dense vegetation where only a few ground points were available. Generally the LAStools algorithm gives good results in every type of terrain, but the ground surface is too smooth. The LIS Progressive Morphological Filter algorithm gives good results in forested flat and low slope areas. The surface-based algorithm from SCOP++ gives good results in mountainous areas - both forested and built-up because it better preserves steep slopes, sharp ridges and breaklines, but sometimes it fails to remove off-terrain objects from the ground class. The segmentation-based algorithm in LIS gives quite good results in built-up flat areas, but in forested areas it does not work well. Bibliography: Axelsson, P., 2000. DEM generation from laser scanner data using adaptive TIN models. International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XXXIII (Pt. B4/1), 110- 117 Kraus, K., Pfeifer, N., 1998. Determination of terrain models in wooded areas with airborne laser scanner data. ISPRS Journal of Photogrammetry & Remote Sensing 53 (4), 193-203 LAStools website http://www.cs.unc.edu/~isenburg/lastools/ (verified in September 2012) Meng, X., Currit, N., Zhao, K., 2010. Ground Filtering Algorithms for Airborne LiDAR Data: A Review of Critical Issues. Remote Sensing 2, 833-860 Sithole, G., Vosselman, G., 2003. Report: ISPRS Comparison of Filters. Commission III, Working Group 3. Department of Geodesy, Faculty of Civil Engineering and Geosciences, Delft University of technology, The Netherlands Sithole, G., Vosselman, G., 2004. Experimental comparison of filter algorithms for bare-Earth extraction form airborne laser scanning point clouds. ISPRS Journal of Photogrammetry & Remote Sensing 59, 85-101 Trimble, 2012 http://www.trimble.com/geospatial/aerial-software.aspx (verified in November 2012) Wichmann, V., 2012. LIS Command Reference, LASERDATA GmbH, 1-231 Zhang, K., Chen, S.-C., Whitman, D., Shyu, M.-L., Yan, J., Zhang, C., 2003. A progressive morphological filter for removing non-ground measurements from airborne LIDAR data. IEEE Transactions on Geoscience and Remote Sensing, 41(4), 872-882

On the Double Pole Structure of the Λ(1405)

NASA Astrophysics Data System (ADS)

Roca, Luis; Nieves, Juan; Oset, Eulogio

In the last decade there have been increased theoretical and experimental evidences about the existence of two poles associated to the Λ(1405). In this contribution we summarize several recent works presenting a successful strategy to extract the position of the two Λ(1405) poles from experimental photoproduction data on the γp → KπΣ reaction at Jefferson Lab. The idea is based on considering a production mechanism as model independent as possible and implementing the final state interaction of the final meson-baryon pair based on small modifications of the unitary chiral perturbation theory amplitudes. Precise values for the two poles of the Λ(1405) resonance are then provided. On the other hand, we also present other work where we analyze theoretically the Λb → J/ψK-p reaction from where a recent LHCb experiment extracts a Λ(1405) contribution in the K-p spectrum close to threshold and two baryon states of hidden charm in the J/ψ p spectrum, claimed to be pentaquarks. By assuming that the observed narrow state around 4450 MeV has a nature stemming mostly from {\\bar{D}}\

Applying Evolutionary Thinking to the Study of Emotion

PubMed Central

Weisfeld, Glenn E.; Goetz, Stefan M. M.

2013-01-01

This paper argues for invoking evolutionary, functional thinking in analyzing emotions. It suggests that the fitness needs of normal individuals be kept in mind when trying to understand emotional behavior. This point of view is elaborated in sections addressing these topics: defining emotion; applying comparative analysis to the study of emotions; focusing on the elicitors and resulting motivated behaviors mediated by the various affects; recognizing that not all emotions have prominent, distinct facial expressions; acknowledging all of the basic emotions and not just some exemplars; crediting the more sensible Cannon-Bard theory over James-Lange; recognizing the more ancient, fundamental role of the limbic system in emotion compared with that of the neocortex; and analyzing socio-emotional interactions as they occur naturally, not just individual emotional behavior studied under artificial conditions. Describing the various facets and neuroendocrine mechanisms of each basic emotion can provide a framework for understanding the normal and pathological development of each emotion. Such an inventory, or ethogram, would provide a comprehensive list of all of the observable behavioral tendencies of our species. PMID:25379244

The Bursts and Lulls of Multimodal Interaction: Temporal Distributions of Behavior Reveal Differences Between Verbal and Non-Verbal Communication.

PubMed

Abney, Drew H; Dale, Rick; Louwerse, Max M; Kello, Christopher T

2018-04-06

Recent studies of naturalistic face-to-face communication have demonstrated coordination patterns such as the temporal matching of verbal and non-verbal behavior, which provides evidence for the proposal that verbal and non-verbal communicative control derives from one system. In this study, we argue that the observed relationship between verbal and non-verbal behaviors depends on the level of analysis. In a reanalysis of a corpus of naturalistic multimodal communication (Louwerse, Dale, Bard, & Jeuniaux, ), we focus on measuring the temporal patterns of specific communicative behaviors in terms of their burstiness. We examined burstiness estimates across different roles of the speaker and different communicative modalities. We observed more burstiness for verbal versus non-verbal channels, and for more versus less informative language subchannels. Using this new method for analyzing temporal patterns in communicative behaviors, we show that there is a complex relationship between verbal and non-verbal channels. We propose a "temporal heterogeneity" hypothesis to explain how the language system adapts to the demands of dialog. Copyright © 2018 Cognitive Science Society, Inc.

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

PubMed

Uckelmann, Michael; Densham, Ruth M; Baas, Roy; Winterwerp, Herrie H K; Fish, Alexander; Sixma, Titia K; Morris, Joanna R

2018-01-15

BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of the DNA damage response, priming chromatin for repair by homologous recombination. However, no specific deubiquitinating enzymes (DUBs) are known to antagonize this function. Here we identify ubiquitin specific protease-48 (USP48) as a H2A DUB, specific for the C-terminal BRCA1 ubiquitination site. Detailed biochemical analysis shows that an auxiliary ubiquitin, an additional ubiquitin that itself does not get cleaved, modulates USP48 activity, which has possible implications for its regulation in vivo. In cells we reveal that USP48 antagonizes BRCA1 E3 ligase function and in BRCA1-proficient cells loss of USP48 results in positioning 53BP1 further from the break site and in extended resection lengths. USP48 repression confers a survival benefit to cells treated with camptothecin and its activity acts to restrain gene conversion and mutagenic single-strand annealing. We propose that USP48 promotes genome stability by antagonizing BRCA1 E3 ligase function.

Impact of survey workflow on precision and accuracy of terrestrial LiDAR datasets

NASA Astrophysics Data System (ADS)

Gold, P. O.; Cowgill, E.; Kreylos, O.

2009-12-01

Ground-based LiDAR (Light Detection and Ranging) survey techniques are enabling remote visualization and quantitative analysis of geologic features at unprecedented levels of detail. For example, digital terrain models computed from LiDAR data have been used to measure displaced landforms along active faults and to quantify fault-surface roughness. But how accurately do terrestrial LiDAR data represent the true ground surface, and in particular, how internally consistent and precise are the mosaiced LiDAR datasets from which surface models are constructed? Addressing this question is essential for designing survey workflows that capture the necessary level of accuracy for a given project while minimizing survey time and equipment, which is essential for effective surveying of remote sites. To address this problem, we seek to define a metric that quantifies how scan registration error changes as a function of survey workflow. Specifically, we are using a Trimble GX3D laser scanner to conduct a series of experimental surveys to quantify how common variables in field workflows impact the precision of scan registration. Primary variables we are testing include 1) use of an independently measured network of control points to locate scanner and target positions, 2) the number of known-point locations used to place the scanner and point clouds in 3-D space, 3) the type of target used to measure distances between the scanner and the known points, and 4) setting up the scanner over a known point as opposed to resectioning of known points. Precision of the registered point cloud is quantified using Trimble Realworks software by automatic calculation of registration errors (errors between locations of the same known points in different scans). Accuracy of the registered cloud (i.e., its ground-truth) will be measured in subsequent experiments. To obtain an independent measure of scan-registration errors and to better visualize the effects of these errors on a registered point cloud, we scan from multiple locations an object of known geometry (a cylinder mounted above a square box). Preliminary results show that even in a controlled experimental scan of an object of known dimensions, there is significant variability in the precision of the registered point cloud. For example, when 3 scans of the central object are registered using 4 known points (maximum time, maximum equipment), the point clouds align to within ~1 cm (normal to the object surface). However, when the same point clouds are registered with only 1 known point (minimum time, minimum equipment), misalignment of the point clouds can range from 2.5 to 5 cm, depending on target type. The greater misalignment of the 3 point clouds when registered with fewer known points stems from the field method employed in acquiring the dataset and demonstrates the impact of field workflow on LiDAR dataset precision. By quantifying the degree of scan mismatch in results such as this, we can provide users with the information needed to maximize efficiency in remote field surveys.

Improved Data Access From the Northern California Earthquake Data Center

NASA Astrophysics Data System (ADS)

Neuhauser, D.; Oppenheimer, D.; Zuzlewski, S.; Klein, F.; Jensen, E.; Gee, L.; Murray, M.; Romanowicz, B.

2002-12-01

The NCEDC is a joint project of the UC Berkeley Seismological Laboratory and the USGS Menlo Park to provide a long-term archive and distribution center for geophysical data for northern California. Most data are available via the Web at http://quake.geo.berkeley.edu and research accounts are available for access to specialized datasets. Current efforts continue to expand the available datasets, enhance distribution methods, and to provide rapid access to all datasets. The NCEDC archives continuous and event-based seismic and geophysical time-series data from the BDSN, the USGS NCSN, the UNR Seismic Network, the Parkfield HRSN, and the Calpine/Unocal Geysers network. In collaboration with the USGS, the NCEDC has archived a total of 887 channels from 139 sites of the "USGS low-frequency" geophysical network (UL), including data from strainmeters, creep meters, magnetometers, water well levels, and tiltmeters. There are 336 active continuous data channels that are updated at the NCEDC on a daily basis. Geodetic data from the BARD network of over 40 continuously recording GPS sites are archived at the NCEDC in both raw and RINEX format. The NCEDC is the primary archive for survey-mode GPS and other geodetic data collected in northern California by the USGS, universities, and other agencies. All of the BARD data and GPS data archived from USGS Menlo Park surveys are now available through the GPS Seamless Archive Centers (GSAC), and by FTP directly from the NCEDC. Virtually all time-series data at the NCEDC are now available in SEED with complete instrument responses. Assembling, verifying, and maintaining the response information for these networks is a huge task, and is accomplished through the collaborative efforts of the NCEDC and the contributing agencies. Until recently, the NCSN waveform data were available only through research accounts and special request methods due to incomplete instrument responses. In the last year, the USGS compiled the necessary descriptions for for both historic and current NCSN instrumentation. The NCEDC and USGS jointly developed a procedure to create and maintain the hardware attributes and instrument responses at the NCEDC for the 3500 NCSN channels. As a result, the NCSN waveform data can now be distributed in SEED format. The NCEDC provides access to waveform data through Web forms, email requests, and programming interfaces. The SeismiQuery Web interface provides information about data holdings. NetDC allows users to retrieve inventory information, instrument responses, and waveforms in SEED format. STP provides both a Web and programming interface to retrieve data in SEED or other user-friendly formats. Through the newly formed California Integrated Seismic Network, we are working with the SCEDC to provide unified access to California earthquake data.

Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.

PubMed

Jones, Marcus B; Montgomery, Christopher P; Boyle-Vavra, Susan; Shatzkes, Kenneth; Maybank, Rosslyn; Frank, Bryan C; Peterson, Scott N; Daum, Robert S

2014-12-19

Staphylococcus aureus is a human pathogen responsible for substantial morbidity and mortality through its ability to cause a number of human infections including bacteremia, pneumonia and soft tissue infections. Of great concern is the emergence and dissemination of methicillin-resistant Staphylococcus aureus strains (MRSA) that are resistant to nearly all β-lactams. The emergence of the USA300 MRSA genetic background among community associated S. aureus infections (CA-MRSA) in the USA was followed by the disappearance of USA400 CA-MRSA isolates. To gain a greater understanding of the potential fitness advantages and virulence capacity of S. aureus USA300 clones, we performed whole genome sequencing of 15 USA300 and 4 USA400 clinical isolates. A comparison of representative genomes of the USA300 and USA400 pulsotypes indicates a number of differences in mobile genome elements. We examined the in vitro gene expression profiles by microarray hybridization and the in vivo transcriptomes during lung infection in mice of a USA300 and a USA400 MRSA strain by performing complete genome qRT-PCR analysis. The unique presence and increased expression of 6 exotoxins in USA300 (12- to 600-fold) compared to USA400 may contribute to the increased virulence of USA300 clones. Importantly, we also observed the up-regulation of prophage genes in USA300 (compared with USA400) during mouse lung infection (including genes encoded by both prophages ΦSa2usa and ΦSa3usa), suggesting that these prophages may play an important role in vivo by contributing to the elevated virulence characteristic of the USA300 clone. We observed differences in the genetic content of USA300 and USA400 strains, as well as significant differences of in vitro and in vivo gene expression of mobile elements in a lung pneumonia model. This is the first study to document the global transcription differences between USA300 and USA400 strains during both in vitro and in vivo growth.

Investigations on the Bundle Adjustment Results from Sfm-Based Software for Mapping Purposes

NASA Astrophysics Data System (ADS)

Lumban-Gaol, Y. A.; Murtiyoso, A.; Nugroho, B. H.

2018-05-01

Since its first inception, aerial photography has been used for topographic mapping. Large-scale aerial photography contributed to the creation of many of the topographic maps around the world. In Indonesia, a 2013 government directive on spatial management has re-stressed the need for topographic maps, with aerial photogrammetry providing the main method of acquisition. However, the large need to generate such maps is often limited by budgetary reasons. Today, SfM (Structure-from-Motion) offers quicker and less expensive solutions to this problem. However, considering the required precision for topographic missions, these solutions need to be assessed to see if they provide enough level of accuracy. In this paper, a popular SfM-based software Agisoft PhotoScan is used to perform bundle adjustment on a set of large-scale aerial images. The aim of the paper is to compare its bundle adjustment results with those generated by more classical photogrammetric software, namely Trimble Inpho and ERDAS IMAGINE. Furthermore, in order to provide more bundle adjustment statistics to be compared, the Damped Bundle Adjustment Toolbox (DBAT) was also used to reprocess the PhotoScan project. Results show that PhotoScan results are less stable than those generated by the two photogrammetric software programmes. This translates to lower accuracy, which may impact the final photogrammetric product.

Emergency Response Imagery Related to Hurricanes Harvey, Irma, and Maria

NASA Astrophysics Data System (ADS)

Worthem, A. V.; Madore, B.; Imahori, G.; Woolard, J.; Sellars, J.; Halbach, A.; Helmricks, D.; Quarrick, J.

2017-12-01

NOAA's National Geodetic Survey (NGS) and Remote Sensing Division acquired and rapidly disseminated emergency response imagery related to the three recent hurricanes Harvey, Irma, and Maria. Aerial imagery was collected using a Trimble Digital Sensor System, a high-resolution digital camera, by means of NOAA's King Air 350ER and DeHavilland Twin Otter (DHC-6) Aircraft. The emergency response images are used to assess the before and after effects of the hurricanes' damage. The imagery aids emergency responders, such as FEMA, Coast Guard, and other state and local governments, in developing recovery strategies and efforts by prioritizing areas most affected and distributing appropriate resources. Collected imagery is also used to provide damage assessment for use in long-term recovery and rebuilding efforts. Additionally, the imagery allows for those evacuated persons to see images of their homes and neighborhoods remotely. Each of the individual images are processed through ortho-rectification and merged into a uniform mosaic image. These remotely sensed datasets are publically available, and often used by web-based map servers as well as, federal, state, and local government agencies. This poster will show the imagery collected for these three hurricanes and the processes involved in getting data quickly into the hands of those that need it most.

COMMITTEES: Proceedings of the 13th Gravitational Waves Data Analysis Workshop (GWDAW13), San Juan, Puerto Rico, 19-22 January 2009 Proceedings of the 13th Gravitational Waves Data Analysis Workshop (GWDAW13), San Juan, Puerto Rico, 19-22 January 2009

NASA Astrophysics Data System (ADS)

2009-10-01

Science Organising Committee (SOC) Bruce Allen, AEI, Germany Patrick Brady, University of Wisconsin Milwaukee, USA Deepto Chakrabarty, MIT, USA Eugenio Coccia, INFN, Gran Sasso, Italy James Cordes, Cornell University, USA Mario Díaz (Chair), University of Texas Brownsville, USA Sam Finn, Penn State, USA Neil Gehrels, NASA GSFC, USA Fredrick A Jenet, University of Texas Brownsville, USA Nobuyuki Kanda, Osaka City University, Japan Erik Katsavounides, MIT, USA Dick Manchester, ATNF, Australia Soumya Mohanty, University of Texas Brownsville, USA Benoit Mours, LAPP-Annecy, France Maria Alessandra Papa, AEI, Germany Kate Scholberg, Duke University, USA Susan Scott, The Australian National University Alberto Vecchio, University of Birmingham, UK Andrea Vicere, INFN - Sezione di Firenze, Italy Stan Whitcomb, LIGO CALTECH, USA Local Organising Committee (LOC) Paulo Freire (Arecibo Observatory, Puerto Rico) Murray Lewis (Arecibo Observatory, Puerto Rico) Wanda Wiley (University of Texas Brownsville, USA)

Interview: An architectural journey: from trees, dendrons/dendrimers to nanomedicine. Interview by Hannah Stanwix.

PubMed

Tomalia, Donald A

2012-07-01

Donald Tomalia received his Bachelor of Arts degree in Chemistry from the University of Michigan (MI, USA). He received his PhD in physical-organic Chemistry from Michigan State University (MI, USA) in 1968 while working at The Dow Chemical Company (MI, USA). In 1990 he moved to Michigan Molecular Institute (MI, USA) as Professor and Director of Nanoscale Chemistry and Architecture. He has subsequently founded three dendrimer based-nanotechnology companies, Dendritech, Inc. (MI, USA), Dendritic Nanotechnologies, Inc. (MI, USA) and NanoSynthons LLC (MI, USA). Donald Tomalia is currently Director of the National Dendrimer & Nanotechnology Center (MI, USA), CEO/founder of NanoSynthons LLC (MI, USA), distinguished visiting Professor, Columbia University (NY, USA) and affiliate Professor, Department of Physics, Virginia Commonwealth University (VA, USA). He is best known for his discovery of dendrimers and has received several awards for his accomplishments and contributions to science, including the 2012 Wallace H Carothers Award. He has authored over 250 publications, as well as over 128 patents.

Modelling the hydrodynamic and morphosedimentary response of an beach-headland system (Algarve, Southern Portugal)

NASA Astrophysics Data System (ADS)

Horta, João; Oliveira, Sónia; Moura, Delminda

2015-04-01

Future behaviour of beaches within a headland-beach system is of fundamental interest on coastal evolution since they act as a buffer between the waves' attack and the cliffs backing them. The beaches at the cliffs' foot anchored between headlands are space-limited environments to morphosedimentary processes. Additionally, headlands and shore platforms are natural barriers to the alongshore drift. Several attempts to develop numerical expressions to characterize the stability of headland-beach systems have been made based mainly on linear parameters. However, in the sandy areas occur volumetric variations of greater magnitude that changes in the shoreline position in a tidal cycle. This work aims to quantify the balance between the incoming and the lost sediment in two embayed beaches in order to improve knowledge of the sedimentary dynamics of such environments and therefore the evolution of coastal landscapes. The study area is the Algarve coastal karstic landscapes, which raises challenging questions on morphosedimentary processes because it has dozens of stacks and cavities both in the surf zone and in the nearshore that interfere with the littoral current patterns. The field campaigns were performed during spring tide conditions in February and March, 2011. The nearshore wave climate and the current's velocity and direction were measured using respectively a non-vented Level TROLL 700 Pressure Transducer (PT) and an autonomously deployable electro-magnetic current meter (EMCM) Infinity-EM with a data logger. The offshore wave data used was acquired through the Portuguese Hydrographic Institute (IH) at the Faro buoy, located 50 km southeast from the study area. The topographic surveys were performed for a total area of about 1500 m2 using two Global Navigation Satellite System receptors (GPS Trimble R6 and GPS Trimble 5800) in real-time kinematic mode (RTK) with differential global positioning system (DGPS) providing centimetric accuracy. The altimetric values ranged between -2 and +6 m (mean sea level-msl). The automatic determination of the spatial characteristics of the beach morphology results from the GIS tools. The wave and current post processing was made using the STWAVE and Bouss-2D model software. Our results showed that: (i) the shore orientation is the major factor for the height of the waves approaching the coast (considering the same offshore climate) and thus to the wave energy input to transport sediment, (ii) the shore platforms which extend up to -7 m (msl) determine a very irregular pattern of the shoaling waves and distance of the breaking point from the shoreline, (iii) as a consequence of (ii) the rip currents in the surf zone show a very complex pattern and the direction of the sedimentary transport can be opposite to the direction of the incoming waves, (iv) the pattern of the rip currents is highly variable depending on the water depth, (v) the results obtained for volumetric balances showed a negative balance (erosion higher than accretion) at the smaller embayed beach and a positive balance (accretion higher than erosion) at the larger one. This work is a contribution to the PTDC/GEO-GEO/3981/2012 funded by the Portuguese Foundation for Science and Technology.

The effect of autoclave resterilisation on polyester vascular grafts.

PubMed

Riepe, G; Whiteley, M S; Wente, A; Rogge, A; Schröder, A; Galland, R B; Imig, H

1999-11-01

polyester grafts are expensive, single-use items. Some manufacturers of uncoated, woven grafts include instructions for autoclave resterilisation to be performed at the surgeon's own request. Others warn against such manipulation. Theoretically, the glass transition point of polyester at 70-80 degrees C and the possible acceleration of hydrolysis suggest that autoclave resterilisation at 135 degrees C might be a problem. a DeBakey Soft Woven Dacron Vascular Prosthesis (Bard) and a Woven Double Velour Dacron Graft (Meadox) were autoclave-resterilised 0 to 20 times, having been weighed before and after sterilisation. Tactile testing was performed. Mechanical properties were examined by probe puncture and single-filament testing, the surface was examined by scanning electron microscopy and the degree of hydrolysis by infra-red spectroscopy. tactile testing revealed a change of feeling with increasing cycles of resterilisation. Investigation of weight, textile strength, single-filament strength, electron microscopy of the surface and infra-red spectroscopy showed no change of the material. changes felt are presumably a surface phenomenon, not measurably affecting strength or chemistry of material after autoclave resterilisation. We therefore feel that it is safe to use once-autoclave-resterilised surplus uncoated polyester grafts, provided that sterility is guaranteed. Copyright 1999 Harcourt Publishers Ltd.

A review of electrochemiluminescence (ECL) in and for microfluidic analytical devices.

PubMed

Kirschbaum, Stefanie E K; Baeumner, Antje J

2015-05-01

The concept and realization of microfluidic total analysis systems (microTAS) have revolutionized the analytical process by integrating the whole breadth of analytical techniques into miniaturized systems. Paramount for efficient and competitive microTAS are integrated detection strategies, which lead to low limits of detection while reducing the sample volume. The concept of electrochemiluminescence (ECL) has been intriguing ever since its introduction based on Ru(bpy)3 (2+) by Tokel and Bard [1] (J Am Chem Soc 1853:2862-2863, 1972), especially because of its immense sensitivity, nonexistent auto-luminescent background signal, and simplicity in experimental design. Therefore, integrating ECL detection into microTAS is a logical consequence to achieve simple, yet highly sensitive, sensors. However, published microanalytical devices employing ECL detection focus in general on traditional ECL chemistry and have yet to take advantage of advances made in standard bench-top ECL strategies. This review will therefore focus on the most recent advancements in microfluidic ECL approaches, but also evaluate the potential impact of bench-top ECL research progress that would further improve performance and lower limits of detection of micro analytical ECL systems, ensuring their desirability as detection principle for microTAS applications.

A different approach to estimate nonlinear regression model using numerical methods

NASA Astrophysics Data System (ADS)

Mahaboob, B.; Venkateswarlu, B.; Mokeshrayalu, G.; Balasiddamuni, P.

2017-11-01

This research paper concerns with the computational methods namely the Gauss-Newton method, Gradient algorithm methods (Newton-Raphson method, Steepest Descent or Steepest Ascent algorithm method, the Method of Scoring, the Method of Quadratic Hill-Climbing) based on numerical analysis to estimate parameters of nonlinear regression model in a very different way. Principles of matrix calculus have been used to discuss the Gradient-Algorithm methods. Yonathan Bard [1] discussed a comparison of gradient methods for the solution of nonlinear parameter estimation problems. However this article discusses an analytical approach to the gradient algorithm methods in a different way. This paper describes a new iterative technique namely Gauss-Newton method which differs from the iterative technique proposed by Gorden K. Smyth [2]. Hans Georg Bock et.al [10] proposed numerical methods for parameter estimation in DAE’s (Differential algebraic equation). Isabel Reis Dos Santos et al [11], Introduced weighted least squares procedure for estimating the unknown parameters of a nonlinear regression metamodel. For large-scale non smooth convex minimization the Hager and Zhang (HZ) conjugate gradient Method and the modified HZ (MHZ) method were presented by Gonglin Yuan et al [12].

The Extreme Ultraviolet spectrometer on bard the Hisaki satellite

NASA Astrophysics Data System (ADS)

Yoshioka, K.; Murakami, G.; Yamazaki, A.; Tsuchiya, F.; Kagitani, M.; Kimura, T.; Yoshikawa, I.

2017-12-01

The extreme ultraviolet spectroscope EXCEED (EXtrem ultraviolet spetrosCope for ExosphEric Dynamics) on board the Hisaki satellite was launched in September 2013 from the Uchinoura space center, Japan. It is orbiting around the Earth with an orbital altitude of around 950-1150 km. This satellite is dedicated to and optimized for observing the atmosphere and magnetosphere of terrestrial planets such as Mercury, Venus, Mars, as well as Jupiter. The instrument consists of an off axis parabolic entrance mirror, switchable slits with multiple filters and shapes, a toroidal grating, and a photon counting detector, together with a field of view guiding camera. The design goal is to achieve a large effective area but with high spatial and spectral resolution. Based on the after-launch calibration, the spectral resolution of EXCEED is found to be 0.3-0.5 nm FWHM (Full Width at Half Maximum) over the entire spectral band, and the spatial resolution is around 17". The evaluated effective area is larger than 1cm2. In this presentation, the basic concept of the instrument design and the observation technique are introduced. The current status of the spacecraft and its future observation plan are also shown.

Rate-controlled analgesia: a laboratory evaluation of a new infusion device.

PubMed

Currie, J; Owen, H; Ilsley, A H

1990-11-01

We report an evaluation of the Bard Harvard Mini Infuser, one of a new generation of agent-specific intraoperative infusion pumps which are designed for use by the anaesthetist. This pump permits potent intravenous anaesthetic agents to be used in pharmacokinetically designed dosage regimens. The controls are calibrated directly in kg body weight and micrograms per minute rather than the usual settings of ml of solution per hour. The performance was assessed by measuring the volume delivered over given time intervals and all safety functions were tested at least three times. This device was found to be acceptably safe and accurate. Two points to note are that it must be purged every time before it is connected to the intravenous infusion and if an occlusion is suddenly relieved, the patient can receive an 'accidental bolus' of up to 1.18 ml of drug. The main advantage of this pump is that it uses undiluted drug direct from the ampoule and does not require any calculations or dilutions prior to use. However, this restricts its use to drugs with a concentration of 500 mcg/ml and in effect means that it is suitable mainly for infusion of alfentanil.

Medical controversies and dilemmas in discussions about the illness and death of Mihai Eminescu (1850-1889) Romania's national poet.

PubMed

Neghina, Raul; Neghina, Adriana Maria

2011-03-01

Mihai Eminescu, the first great Romanian poet and a defining figure in Romanian culture, may be situated among the most important romantic bards of his times--Byron, Novalis, Holderlin, Hugo, Lamartine, and Leopardi. He was born to a family affected by tuberculosis and predisposed to mental disorders. Although Eminescu may have suffered from bipolar disorder and may have been killed by iatrogenic mercury poisoning, erysipelas, head trauma, or endocarditis, his final illness and death continue to be associated with the most stigmatized disease of those times, syphilis. This historical review addresses the pros and cons of arguments about the diseases from which Eminescu may have suffered, as well as their causes and consequences. The key question is whether syphilis was the disease that led to Eminescu's death. After reviewing medical hypotheses, we conclude that he suffered from bipolar disorder and died from mercury poisoning, an inadequate treatment administered as the result of an inaccurate diagnosis (syphilis). Hospitalized in inappropriate places and treated by incompetent physicians, he suffered not only physical, but moral, distress and died prematurely. According to a letter he sent to a friend, he rightly considered himself a sacrificed man.

Committees and sponsors

NASA Astrophysics Data System (ADS)

2011-10-01

International Advisory Committee Richard F CastenYale, USA Luiz Carlos ChamonSão Paulo, Brazil Osvaldo CivitareseLa Plata, Argentina Jozsef CsehATOMKI, Hungary Jerry P DraayerLSU, USA Alfredo Galindo-UribarriORNL & UT, USA James J KolataNotre Dame, USA Jorge López UTEP, USA Joseph B NatowitzTexas A & M, USA Ma Esther Ortiz IF-UNAM Stuart PittelDelaware, USA Andrés SandovalIF-UNAM Adam SzczepaniakIndiana, USA Piet Van IsackerGANIL, France Michael WiescherNotre Dame, USA Organizing Committee Libertad Barrón-Palos (Chair)IF-UNAM Roelof BijkerICN-UNAM Ruben FossionICN-UNAM David LizcanoININ Sponsors Instituto de Ciencias Nucleares, UNAMInstituto de Física, UNAMInstituto Nacional de Investigaciones NuclearesDivisión de Física Nuclear de la SMFCentro Latinoamericano de Física

Echinococcus granulosus in gray wolves and ungulates in Idaho and Montana, USA.

PubMed

Foreyt, William J; Drew, Mark L; Atkinson, Mark; McCauley, Deborah

2009-10-01

We evaluated the small intestines of 123 gray wolves (Canis lupus) that were collected from Idaho, USA (n=63), and Montana, USA (n=60), between 2006 and 2008 for the tapeworm Echinococcus granulosus. The tapeworm was detected in 39 of 63 wolves (62%) in Idaho, USA, and 38 of 60 wolves (63%) in Montana, USA. The detection of thousands of tapeworms per wolf was a common finding. In Idaho, USA, hydatid cysts, the intermediate form of E. granulosus, were detected in elk (Cervus elaphus), mule deer (Odocoileus hemionus), and a mountain goat (Oreamnos americanus). In Montana, USA, hydatid cysts were detected in elk. To our knowledge, this is the first report of adult E. granulosus in Idaho, USA, or Montana, USA. It is unknown whether the parasite was introduced into Idaho, USA, and southwestern Montana, USA, with the importation of wolves from Alberta, Canada, or British Columbia, Canada, into Yellowstone National Park, Wyoming, USA, and central Idaho, USA, in 1995 and 1996, or whether the parasite has always been present in other carnivore hosts, and wolves became a new definitive host. Based on our results, the parasite is now well established in wolves in these states and is documented in elk, mule deer, and a mountain goat as intermediate hosts.

COMMITTEES: Quark Matter 2008 Organising and International Advisory Committees

NASA Astrophysics Data System (ADS)

2008-10-01

Organising Committee Madan M Aggarwal (Chandigarh) Jan-e Alam (Kolkata) Convener Arup Bandyopadhyay (Kolkata) Debades Bandyopadhyay (Kolkata) Rahul Basu (Chennai) Rakesh K Bhandari (Kolkata) Anju Bhasin (Jammu) Subhasis Chattopadhyay (Kolkata) Convener Sukalyan Chattopadhyay (Kolkata) Asis Chaudhuri (Kolkata) Premomoy Ghosh (Kolkata) Sanjay Ghosh (Kolkata) Sourendu Gupta (Mumbai) Muhammad Irfan (Aligarh) Durga P Mahapatra (Bhubaneswar) DAmruta Mishra (New Delhi) Ajit K Mohanty (Mumbai) Bedangadas Mohanty (Kolkata) Vaisali Naik (Kolkata) Tapan K Nayak (Kolkata) Convener Sudhir Raniwala (Jaipur) Sourav Sarkar (Kolkata) Bikash Sinha (Kolkata) Chair Dinesh Srivastava (Kolkata) Raghava Varma (Mumbai) Yogendra P Viyogi (Bhubaneswar)Co-chair International Advisory Committee R Aymar,Switzerland Jean Paul Blaizot, France Peter Braun Münzinger, Germany Igor M Dremin, Russia Kari Eskola, Finland Jens Jorgen Gaardhoje,Denmark Rajiv V Gavai, India Hans-Ake Gustaffson, Sweden Hans Gutbrod, Germany Miklos Gyulassy, USA Timothy Hallman, USA Hideki Hamagaki, Japan Tetsuo Hatsuda, Japan Huan-Zhong Huang, USA Barbara Jacak, USA Peter Jenni, Switzerland Taka Kajino, Japan Takeshi Kodama, Brazil T D Lee, USA Peter Levai, Hungary Luciano Maiani, Italy Larry McLerran, USA Berndt Müller, USA Guy Paic, Mexico Sibaji Raha, India Lodovico Riccati, Italy Hans Georg Ritter, USA Helmut Satz, Germany Jurgen Schukraft, Switzerland Yves Schutz, France Edward V Shuryak, USA Johanna Stachel, Germany Horst Stöcker, Germany Itzhak Tserruya, Israel Xin-Nian Wang, USA Bolek Wyslouch, USA Glenn R Young, USA William A Zajc, USA Wen-Long Zhan, China

Histologic and biomechanical evaluation of a novel macroporous polytetrafluoroethylene knit mesh compared to lightweight and heavyweight polypropylene mesh in a porcine model of ventral incisional hernia repair

PubMed Central

Melman, L.; Jenkins, E. D.; Hamilton, N. A.; Bender, L. C.; Brodt, M. D.; Deeken, C. R.; Greco, S. C.; Frisella, M. M.

2013-01-01

Purpose To evaluate the biocompatibility of heavyweight polypropylene (HWPP), lightweight polypropylene (LWPP), and monofilament knit polytetrafluoroethylene (mkPTFE) mesh by comparing biomechanics and histologic response at 1, 3, and 5 months in a porcine model of incisional hernia repair. Methods Bilateral full-thickness abdominal wall defects measuring 4 cm in length were created in 27 Yucatan minipigs. Twenty-one days after hernia creation, animals underwent bilateral preperitoneal ventral hernia repair with 8 × 10 cm pieces of mesh. Repairs were randomized to Bard®Mesh (HWPP, Bard/Davol, http://www.davol.com), ULTRAPRO® (LWPP, Ethicon, http://www.ethicon.com), and GORE®INFINIT Mesh (mkPTFE, Gore & Associates, http://www.gore.com). Nine animals were sacrificed at each timepoint (1, 3, and 5 months). At harvest, a 3 × 4 cm sample of mesh and incorporated tissue was taken from the center of the implant site and subjected to uniaxial tensile testing at a rate of 0.42 mm/s. The maximum force (N) and tensile strength (N/cm) were measured with a tensiometer, and stiffness (N/mm) was calculated from the slope of the force-versus-displacement curve. Adjacent sections of tissue were stained with hematoxylin and eosin (H&E) and analyzed for inflammation, fibrosis, and tissue ingrowth. Data are reported as mean ± SEM. Statistical significance (P < 0.05) was determined using a two-way ANOVA and Bonferroni post-test. Results No significant difference in maximum force was detected between meshes at any of the time points (P > 0.05 for all comparisons). However, for each mesh type, the maximum strength at 5 months was significantly lower than that at 1 month (P < 0.05). No significant difference in stiffness was detected between the mesh types or between timepoints (P > 0.05 for all comparisons). No significant differences with regard to inflammation, fibrosis, or tissue ingrowth were detected between mesh types at any time point (P > 0.09 for all comparisons). However, over time, inflammation decreased significantly for all mesh types (P < 0.001) and tissue ingrowth reached a slight peak between 1 and 3 months (P = 0.001) but did not significantly change thereafter (P > 0.09). Conclusions The maximum tensile strength of mesh in the abdominal wall decreased over time for HWPP, LWPP, and mkPTFE mesh materials alike. This trend may actually reflect inability to adequately grip specimens at later time points rather than any mesh-specific trend. Histologically, inflammation decreased with time (P = 0.000), and tissue ingrowth increased (P = 0.019) for all meshes. No specific trends were observed between the polypropylene meshes and the monofilament knit PTFE, suggesting that this novel construction may be a suitable alternative to existing polypropylene meshes. PMID:21279663

Histologic and biomechanical evaluation of a novel macroporous polytetrafluoroethylene knit mesh compared to lightweight and heavyweight polypropylene mesh in a porcine model of ventral incisional hernia repair.

PubMed

Melman, L; Jenkins, E D; Hamilton, N A; Bender, L C; Brodt, M D; Deeken, C R; Greco, S C; Frisella, M M; Matthews, B D

2011-08-01

To evaluate the biocompatibility of heavyweight polypropylene (HWPP), lightweight polypropylene (LWPP), and monofilament knit polytetrafluoroethylene (mkPTFE) mesh by comparing biomechanics and histologic response at 1, 3, and 5 months in a porcine model of incisional hernia repair. Bilateral full-thickness abdominal wall defects measuring 4 cm in length were created in 27 Yucatan minipigs. Twenty-one days after hernia creation, animals underwent bilateral preperitoneal ventral hernia repair with 8 × 10 cm pieces of mesh. Repairs were randomized to Bard(®)Mesh (HWPP, Bard/Davol, http://www.davol.com), ULTRAPRO(®) (LWPP, Ethicon, http://www.ethicon.com), and GORE(®)INFINIT Mesh (mkPTFE, Gore & Associates, http://www.gore.com). Nine animals were sacrificed at each timepoint (1, 3, and 5 months). At harvest, a 3 × 4 cm sample of mesh and incorporated tissue was taken from the center of the implant site and subjected to uniaxial tensile testing at a rate of 0.42 mm/s. The maximum force (N) and tensile strength (N/cm) were measured with a tensiometer, and stiffness (N/mm) was calculated from the slope of the force-versus-displacement curve. Adjacent sections of tissue were stained with hematoxylin and eosin (H&E) and analyzed for inflammation, fibrosis, and tissue ingrowth. Data are reported as mean ± SEM. Statistical significance (P < 0.05) was determined using a two-way ANOVA and Bonferroni post-test. No significant difference in maximum force was detected between meshes at any of the time points (P > 0.05 for all comparisons). However, for each mesh type, the maximum strength at 5 months was significantly lower than that at 1 month (P < 0.05). No significant difference in stiffness was detected between the mesh types or between timepoints (P > 0.05 for all comparisons). No significant differences with regard to inflammation, fibrosis, or tissue ingrowth were detected between mesh types at any time point (P > 0.09 for all comparisons). However, over time, inflammation decreased significantly for all mesh types (P < 0.001) and tissue ingrowth reached a slight peak between 1 and 3 months (P = 0.001) but did not significantly change thereafter (P > 0.09). The maximum tensile strength of mesh in the abdominal wall decreased over time for HWPP, LWPP, and mkPTFE mesh materials alike. This trend may actually reflect inability to adequately grip specimens at later time points rather than any mesh-specific trend. Histologically, inflammation decreased with time (P = 0.000), and tissue ingrowth increased (P = 0.019) for all meshes. No specific trends were observed between the polypropylene meshes and the monofilament knit PTFE, suggesting that this novel construction may be a suitable alternative to existing polypropylene meshes.

76 FR 59167 - Siemens Medical Solutions USA, Inc., Oncology Care Systems Division, Concord, CA; Siemens Medical...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

... Medical Solutions USA, Inc., Oncology Care Systems Division, Concord, CA; Siemens Medical Solutions USA... Solutions USA, Inc. (Siemens), Oncology Care Systems Division, Concord, California (subject firm). The...., Oncology Care Systems Division, Concord, California (TA-W-73,158) and Siemens Medical Solutions USA, Inc...

Formation of Ground Truth Databases and Related Studies and Regional Seismic Monitoring Research

DTIC Science & Technology

2006-06-01

denoted by black circles) and those derived by the combined use of both IRIS and revised IDC for all 70 Chinese events. Arrows point towards the...IRIS data provide a large number of additional Lg amvals. Figure 45. Differences in epicentral location between the original REB (denoted by black ...Washington, USA Haystack Fork , Wyoming, USA Hells Canyon, Colorado, USA Hiawatha Road, Colorado, USA Hockley, Texas, USA Hailey, Idaho, USA Honiara

Chlorhexidine gluconate reduces transmission of methicillin-resistant Staphylococcus aureus USA300 among Marine recruits.

PubMed

Whitman, Timothy J; Schlett, Carey D; Grandits, Greg A; Millar, Eugene V; Mende, Katrin; Hospenthal, Duane R; Murray, Patrick R; Tribble, David R

2012-08-01

Methicillin-resistant Staphylococcus aureus (MRSA) pulsed-field type (PFT) USA300 causes skin and soft tissue infections in military recruits and invasive disease in hospitals. Chlorhexidine gluconate (CHG) is used to reduce MRSA colonization and infection. The impact of CHG on the molecular epidemiology of MRSA is not known. To evaluate the impact of 2% CHG-impregnated cloths on the molecular epidemiology of MRSA colonization. Cluster-randomized, double-blind, controlled trial. Marine Officer Candidate School, Quantico, Virginia, in 2007. Military recruits. Thrice-weekly application of CHG-impregnated or control (Comfort Bath; Sage) cloths over the entire body. Baseline and serial (every 2 weeks) nasal and/or axillary swab samples were assessed for MRSA colonization. Molecular analysis was performed with pulsed-field gel electrophoresis. During training, 77 subjects (4.9%) acquired MRSA, 26 (3.3%) in the CHG group and 51 (6.5%) in the control group (P=.004). When analyzed for PFT, 24 subjects (3.1%) in the control group but only 6 subjects (0.8%) in the CHG group (P=.001) had USA300. Of the 167 colonizing isolates recovered from 77 subjects, 99 were recovered from the control group, including USA300 (40.4%), USA800 (38.4%), USA1000 (12.1%), and USA100 (6.1%), and 68 were recovered from the CHG group, including USA800 (51.5%), USA100 (23.5%), and USA300 (13.2%). CHG decreased the transmission of MRSA--more specifically, USA300--among military recruits. In addition, USA300 and USA800 outcompeted other MRSA PFTs at incident colonization. Future studies should evaluate the broad-based use of CHG to decrease transmission of USA300 in hospital settings.

Chlorhexidine Gluconate Reduces Transmission of Methicillin-Resistant Staphylococcus aureus USA300 among Marine Recruits

PubMed Central

Whitman, Timothy J.; Schlett, Carey D.; Grandits, Greg A.; Millar, Eugene V.; Mende, Katrin; Hospenthal, Duane R.; Murray, Patrick R.; Tribble, David R.

2018-01-01

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) pulsed-field type (PFT) USA300 causes skin and soft tissue infections in military recruits and invasive disease in hospitals. Chlorhexidine gluconate (CHG) is used to reduce MRSA colonization and infection. The impact of CHG on the molecular epidemiology of MRSA is not known. OBJECTIVE To evaluate the impact of 2% CHG–impregnated cloths on the molecular epidemiology of MRSA colonization. DESIGN Cluster-randomized, double-blind, controlled trial. SETTING Marine Officer Candidate School, Quantico, Virginia, in 2007. PARTICIPANTS Military recruits. INTERVENTION Thrice-weekly application of CHG-impregnated or control (Comfort Bath; Sage) cloths over the entire body. MEASUREMENTS Baseline and serial (every 2 weeks) nasal and/or axillary swab samples were assessed for MRSA colonization. Molecular analysis was performed with pulsed-field gel electrophoresis. RESULTS During training, 77 subjects (4.9%) acquired MRSA, 26 (3.3%) in the CHG group and 51 (6.5%) in the control group (P = .004). When analyzed for PFT, 24 subjects (3.1%) in the control group but only 6 subjects (0.8%) in the CHG group (P = .001) had USA300. Of the 167 colonizing isolates recovered from 77 subjects, 99 were recovered from the control group, including USA300 (40.4%), USA800 (38.4%), USA1000 (12.1%), and USA100 (6.1%), and 68 were recovered from the CHG group, including USA800 (51.5%), USA100 (23.5%), and USA300 (13.2%). CONCLUSIONS CHG decreased the transmission of MRSA—more specifically, USA300—among military recruits. In addition, USA300 and USA800 outcompeted other MRSA PFTs at incident colonization. Future studies should evaluate the broad-based use of CHG to decrease transmission of USA300 in hospital settings. PMID:22759549

77 FR 6587 - Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-75,089; TA-W-75,089A] Startek USA, Inc. Alexandria, LA; Startek USA, Inc., Collinsville, VA; Amended Certification Regarding Eligibility... for Worker Adjustment Assistance on January 26, 2011, applicable to workers of StarTek USA, Inc...

The Effect of Added AL2O3 on the Propagation Behavior of an Al/CuO Nanoscale Thermite

DTIC Science & Technology

2008-01-01

Malchi a, Richard A. Yetter a,*, T. J. Foley b, and Steven F. Son c a The Pennsylvania State University, University Park, PA, USA b Los Alamos National...Laboratory, Los Alamos, NM, USA c Purdue University, West Lafayette, IN, USA U. S. Army Research Office P.O. Box 12211 Research Triangle Park, NC...Pennsylvania State University, University Park, PA, USA b Los Alamos National Laboratory, Los Alamos, NM, USA c Purdue University, West Lafayette, IN, USA

Clinical outcomes of osteomyelitis patients infected with methicillin-resistant Staphylococcus aureus USA-300 strains.

PubMed

Peyrani, P; Allen, M; Seligson, D; Roberts, C; Chen, A; Haque, N; Zervos, M; Wiemken, T; Harting, J; Christensen, D; Ramirez, R

2012-03-01

Methicillin-resistant Staphylococcus aureus (MRSA) USA-300 strains have emerged as an important cause of community-acquired infections. These strains have been recognized as an etiology of osteomyelitis but data on their incidence and outcomes are limited. We retrospectively studied the incidence and clinical outcomes of MRSA USA-300 osteomyelitis in patients at the University of Louisville Hospital and the Henry Ford Health System between January 2007 and March 2008. Pulsed-field gel electrophoresis was used to determine USA type. Clinical outcomes were defined as management success versus failure at 12 months. Chi-square tests, Fisher exact tests, and Mann-Whitney tests were used to compare patient characteristics on the basis of clinical outcomes and USA type. Of the 50 patients with MRSA osteomyelitis, 27 (54%) had the USA-300 strain. Clinical failure was identified in 22% (6/27) of the patients with MRSA USA-300 and in 30% (7/23) of the patients with MRSA non-USA-300 osteomyelitis (P = .509). Our results showed that MRSA USA-300 is a significant etiology of MRSA osteomyelitis. With current surgical and medical management, outcomes of patients with MRSA USA-300 osteomyelitis are similar to those of patients with MRSA non-USA-300 osteomyelitis.

78 FR 4400 - Eni USA Gas Marketing LLC; Application for Blanket Authorization To Export Previously Imported...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-22

... DEPARTMENT OF ENERGY [FE Docket No. 12-161-LNG] Eni USA Gas Marketing LLC; Application for Blanket..., by Eni USA Gas Marketing LLC (Eni USA Gas Marketing), requesting blanket authorization to export... U.S. law or policy. Eni USA Gas Marketing is requesting this authorization both on its own behalf...

Relationship between COMLEX-USA scores and performance on the American Osteopathic Board of Emergency Medicine Part I certifying examination.

PubMed

Li, Feiming; Gimpel, John R; Arenson, Ethan; Song, Hao; Bates, Bruce P; Ludwin, Fredric

2014-04-01

Few studies have investigated how well scores from the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) series predict resident outcomes, such as performance on board certification examinations. To determine how well COMLEX-USA predicts performance on the American Osteopathic Board of Emergency Medicine (AOBEM) Part I certification examination. The target study population was first-time examinees who took AOBEM Part I in 2011 and 2012 with matched performances on COMLEX-USA Level 1, Level 2-Cognitive Evaluation (CE), and Level 3. Pearson correlations were computed between AOBEM Part I first-attempt scores and COMLEX-USA performances to measure the association between these examinations. Stepwise linear regression analysis was conducted to predict AOBEM Part I scores by the 3 COMLEX-USA scores. An independent t test was conducted to compare mean COMLEX-USA performances between candidates who passed and who failed AOBEM Part I, and a stepwise logistic regression analysis was used to predict the log-odds of passing AOBEM Part I on the basis of COMLEX-USA scores. Scores from AOBEM Part I had the highest correlation with COMLEX-USA Level 3 scores (.57) and slightly lower correlation with COMLEX-USA Level 2-CE scores (.53). The lowest correlation was between AOBEM Part I and COMLEX-USA Level 1 scores (.47). According to the stepwise regression model, COMLEX-USA Level 1 and Level 2-CE scores, which residency programs often use as selection criteria, together explained 30% of variance in AOBEM Part I scores. Adding Level 3 scores explained 37% of variance. The independent t test indicated that the 397 examinees passing AOBEM Part I performed significantly better than the 54 examinees failing AOBEM Part I in all 3 COMLEX-USA levels (P<.001 for all 3 levels). The logistic regression model showed that COMLEX-USA Level 1 and Level 3 scores predicted the log-odds of passing AOBEM Part I (P=.03 and P<.001, respectively). The present study empirically supported the predictive and discriminant validities of the COMLEX-USA series in relation to the AOBEM Part I certification examination. Although residency programs may use COMLEX-USA Level 1 and Level 2-CE scores as partial criteria in selecting residents, Level 3 scores, though typically not available at the time of application, are actually the most statistically related to performances on AOBEM Part I.

KSC-04pd0524

NASA Image and Video Library

2004-03-05

KENNEDY SPACE CENTER, FLA. - The STS-114 crew pose for a photo in front of a solid rocket booster aft skirt in the SRB Assembly and Refurbishment Facility. In front, from left, are Cynthia Perrons, electrical technician with United Space Alliance; Commander Eileen Collins, Pilot James Kelly, and Mission Specialists Charles Camarda and Andrew Thomas. In back are Paul Gutierrez, associate program manager in SRB Element, USA; John Cleary Jr., electrical engineer with USA; Mike Leppert, project lead, Manufacturing Operations, USA; Don Noah, Materials and Processes engineer, USA; Bob Herman, deputy associate program manager, SRB Element, USA; Mission Specialist Soichi Noguchi; Dale Marlow, thermal protection system engineer with USA; Mission Specialist Stephen Robinson; Greg Henry, director, Manufacturing Operations, USA.

77 FR 27082 - StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,850; TA-W-74,850A] StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO; Amended... workers and former workers of StarTek USA, Inc., Greeley, Colorado. The Department's notice of...

Comparative study of scientific publications in orthopedics journals originating from USA, Japan and China (2000-2012).

PubMed

Lao, Li-Feng; Daubs, Michael David; Phan, Kevin H; Wang, Jeffrey C

2013-11-01

To compare orthopedics publications from USA, Japan and China. Scientific papers belong to ''Orthopedics'' category of Science Citation Index Expanded subject categories were retrieved from the "PubMed'' and ''Web of Knowledge'' online databases. In the field of orthopedics, the annual number increased significantly from 2000 to 2012 in the three countries (p<0.001). The share of articles increased significantly in China, but decreased significantly in Japan and USA (p<0.05). In 2012, USA contributed 35.3% of the total world output in orthopedics field and ranked 1st; Japan contributed 5.9% and ranked 4th; China contributed 5.2% and ranked 5th. Publications from USA had the highest accumulated IFs and the highest total citations of articles (USA > Japan > China, p<0.001). Average IF from USA was much higher than Japan and China (p<0.001). USA published the most articles in the top ten orthopedics journals (USA (14355) > Japan (1702) > China (487), p<0.01). Although China has undergone significant increase in annual number and percentage of scientific publication in orthopedics journals, it still lags far behind USA and Japan in the field of orthopedics in terms of quantity and quality.

Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus.

PubMed

Tattevin, Pierre; Schwartz, Brian S; Graber, Christopher J; Volinski, Joann; Bhukhen, Akta; Bhukhen, Arti; Mai, Thuy T; Vo, Nhung H; Dang, Denise N; Phan, Tiffany HaiVan; Basuino, Li; Perdreau-Remington, Françoise; Chambers, Henry F; Diep, Binh An

2012-09-01

Since its emergence in 2000, epidemic spread of the methicillin-resistant Staphylococcus aureus (MRSA) clone USA300 has led to a high burden of skin and soft tissue infections (SSTIs) in the United States, yet its impact on MRSA bloodstream infections (BSIs) is poorly characterized. To assess clonality of the MRSA isolates causing SSTI and BSI during the epidemic period, a stratified, random sample of 1350 unique infection isolates (from a total of 7252) recovered at the Community Health Network of San Francisco from 2000 to 2008 were selected for genotyping. Risk factors and outcomes for 549 BSI cases caused by the USA300 epidemic clone and non-USA300 MRSA clones were assessed by retrospective review of patient medical records. From 2000 to 2008, secular trends of USA300 SSTI and USA300 BSI were strongly correlated (Pearson r = 0.953). USA300 accounted for 55% (304/549) of BSIs as it was the predominant MRSA clone that caused community-associated (115/160), healthcare-associated community-onset (125/207), and hospital-onset (64/182) BSIs. Length of hospitalization after BSI diagnosis and mortality rates for USA300 and non-USA300 were similar. Two independent risk factors for USA300 BSI were identified: concurrent SSTI (adjusted relative risk, 1.4 [95% confidence interval {CI}, 1.2-1.6]) and anti-MRSA antimicrobial use in the preceding 30 days (0.7 [95% CI, .6-.8]). Isolates from concurrent SSTI were indistinguishable genotypically from the USA300 isolates that caused BSI. USA300 SSTIs serve as a source for BSI. Strategies to control the USA300 SSTI epidemic may lessen the severity of the concurrent USA300 BSI epidemic.

Saturn Apollo Program

NASA Image and Video Library

1969-07-25

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. This photograph was taken as the mission’s first loaded sample return container arrived at Ellington Air Force Base by air from the Pacific recovery area. The rock box was immediately taken to the Lunar Receiving Laboratory at the Manned Spacecraft Center (MSC) in Houston, Texas. Happily posing for the photograph with the rock container are (L-R) Richard S. Johnston (back), special assistant to the MSC Director; George M. Low, MSC Apollo Spacecraft Program manager; George S. Trimble (back), MSC Deputy Director; Lt. General Samuel C. Phillips, Apollo Program Director, Office of Manned Spaceflight at NASA headquarters; Eugene G. Edmonds, MSC Photographic Technology Laboratory; Dr. Thomas O. Paine, NASA Administrator; and Dr. Robert R. Gilruth, MSC Director.

Ionospheric modifications detected by a dense network of single frequency GNSS receivers

NASA Astrophysics Data System (ADS)

Mrak, S.; Semeter, J. L.

2017-12-01

It has been predicted that the region of totality during a total solar eclipse can launch atmospheric gravity waves with large enough amplitude to cause traveling ionospheric disturbances (TIDs). We report initial results from a remote sensing campaign involving a dense hybrid network of single- and dual-frequency GNSS receivers deployed underneath the 21 August 2017 solar eclipse. The campaign took place in central Missouri, involving 84 Trimble dual-frequency receivers, complemented by 2 additional 50 Hz dual-frequency receivers and 15 single-frequency receivers, together constructing 100 receivers with average mutual separation of less than 25 km and with a time resolution of 1 second or better. The initial results show a crescent shaped enhancement bulge in front of region of totality, extending all the way from Canada to Gulf of Mexico. In addition, in the path of totality is noticed a great depletion region, followed by a pair of transverse waves propagating in west-east direction. In the following months, we will explore the transition region carried by the totality by a virtue of hyper dense network of GNSS receivers with 1 second resolution. In addition to TEC data decomposition we will explore effects of the totality on the raw measurements (phase, code and signal intensity), and to the navigation solution which is likely to be effected by a different propagation conditions with respect to other days.

Investigation of a L1-optimized choke ring ground plane for a low-cost GPS receiver-system

NASA Astrophysics Data System (ADS)

Zhang, Li; Schwieger, Volker

2018-01-01

Besides the geodetic dual-frequency GNSS receivers-systems (receiver and antenna), there are also low-cost single-frequency GPS receiver-systems. The multipath effect is a limiting factor of accuracy for both geodetic dual-frequency and low-cost single-frequency GPS receivers. And the multipath effect is for the short baselines dominating error (typical for the monitoring in Engineering Geodesy). So accuracy and reliability of GPS measurement for monitoring can be improved by reducing the multipath signal. In this paper, the self-constructed L1-optimized choke ring ground plane (CR-GP) is applied to reduce the multipath signal. Its design will be described and its performance will be investigated. The results show that the introduced low-cost single-frequency GPS receiver-system, which contains the Ublox LEA-6T single-frequency GPS receiver and Trimble Bullet III antenna with a self-constructed L1-optimized CR-GP, can reach standard deviations of 3 mm in east, 5 mm in north and 9 mm in height in the test field which has many reflectors. This accuracy is comparable with the geodetic dual-frequency GNSS receiver-system. The improvement of the standard deviation of the measurement using the CR-GP is about 50 % and 35 % compared to the used antenna without shielding and with flat ground plane respectively.

First Apollo 11 Lunar Samples Arrive at the Manned Spacecraft Center (MSC)

NASA Technical Reports Server (NTRS)

1969-01-01

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. This photograph was taken as the mission's first loaded sample return container arrived at Ellington Air Force Base by air from the Pacific recovery area. The rock box was immediately taken to the Lunar Receiving Laboratory at the Manned Spacecraft Center (MSC) in Houston, Texas. Happily posing for the photograph with the rock container are (L-R) Richard S. Johnston (back), special assistant to the MSC Director; George M. Low, MSC Apollo Spacecraft Program manager; George S. Trimble (back), MSC Deputy Director; Lt. General Samuel C. Phillips, Apollo Program Director, Office of Manned Spaceflight at NASA headquarters; Eugene G. Edmonds, MSC Photographic Technology Laboratory; Dr. Thomas O. Paine, NASA Administrator; and Dr. Robert R. Gilruth, MSC Director.

Improving the Quality of Low-Cost GPS Receiver Data for Monitoring Using Spatial Correlations

NASA Astrophysics Data System (ADS)

Zhang, Li; Schwieger, Volker

2016-06-01

The investigations on low-cost single frequency GPS receivers at the Institute of Engineering Geodesy (IIGS) show that u-blox LEA-6T GPS receivers combined with Trimble Bullet III GPS antennas containing self-constructed L1-optimized choke rings can already obtain an accuracy in the range of millimeters which meets the requirements of geodetic precise monitoring applications (see [27]). However, the quality (accuracy and reliability) of low-cost GPS receiver data, particularly in shadowing environment, should still be improved, since the multipath effects are the major error for the short baselines. For this purpose, several adjoined stations with low-cost GPS receivers and antennas were set up next to the metal wall on the roof of the IIGS building and measured statically for several days. The time series of three-dimensional coordinates of the GPS receivers were analyzed. Spatial correlations between the adjoined stations, possibly caused by multipath effect, will be taken into account. The coordinates of one station can be corrected using the spatial correlations of the adjoined stations, so that the quality of the GPS measurements is improved. The developed algorithms are based on the coordinates and the results will be delivered in near-real-time (in about 30 minutes), so that they are suitable for structural health monitoring applications.

Theoretical and Applied Research in the Field of Higher Geodesy Conducted in Rzeszow

NASA Astrophysics Data System (ADS)

Kadaj, Roman; Świętoń, Tomasz

2016-06-01

Important qualitative changes were taking place in polish geodesy in last few years. It was related to application of new techniques and technologies and to introduction of European reference frames in Poland. New reference stations network ASG-EUPOS, together with Internet services which helps in precise positioning was created. It allows to fast setting up precise hybrid networks. New, accurate satellite networks became the basis of new definitions in the field of reference systems. Simultaneously arise the need of new software, which enables to execute the geodetic works in new technical conditions. Authors had an opportunity to participate in mentioned undertakings, also under the aegis of GUGiK, by creation of methods, algorithms and necessary software tools. In this way the automatic postprocessing module (APPS) in POZGEO service, a part of ASG-EUPOS system came into being. It is an entirely polish product which works in Trimble environment. Universal software for transformation between PLETRF89, PL-ETRF2000, PULKOWO'42 reference systems as well as defined coordinate systems was created (TRANSPOL v. 2.06) and published as open product. An essential functional element of the program is the quasi-geoid model PL-geoid-2011, which has been elaborated by adjustment (calibration) of the global quasi-geoid model EGM2008 to 570 geodetic points (satellite-leveling points). Those and other studies are briefly described in this paper.

78 FR 49270 - Information Collection; MyUSA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-13

... Floor, Washington, DC 20405- 0001. ATTN: Hada Flowers/IC 3090-00XX; MyUSA. Instructions: Please submit...-4755. ATTN: Hada Flowers/ IC 3090-00xx; MyUSA. Please cite OMB Control No. 3090-XXXX; MyUSA, in all...

77 FR 47671 - TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA-W-81,520G, T-Mobile USA, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... DEPARTMENT OF LABOR Employment and Training Administration TA-W-81,520, T-Mobile USA, Inc., Call Center, Allentown, PA; TA- W-81,520G, T-Mobile USA, Inc., Headquarters Office, Bellevue, WA; Amended... of T-Mobile USA, Inc., Call Center, Allentown, Pennsylvania (TA-W-81,520), Fort Lauderdale, Florida...

78 FR 76711 - Royal City Charter Coach Lines Ltd.-Acquisition of Control-Quick Coach Lines Ltd. d/b/a Quick...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

... current ownership of Quick, and its wholly owned subsidiary Quick Coach Lines USA Inc. (Quick USA... passengers (MC-205116). Quick USA is a wholly owned subsidiary of Quick. When Royal acquires control of Quick, it will also obtain control of Quick USA. Quick USA is currently inactive and does not provide any...

MRSA USA300 at Alaska Native Medical Center, Anchorage, Alaska, USA, 2000–2006

PubMed Central

Rudolph, Karen M.; Hennessy, Thomas W.; Zychowski, Diana L.; Asthi, Karthik; Boyle-Vavra, Susan; Daum, Robert S.

2012-01-01

To determine whether methicillin-resistant Staphylococcus aureus (MRSA) USA300 commonly caused infections among Alaska Natives, we examined clinical MRSA isolates from the Alaska Native Medical Center, Anchorage, during 2000–2006. Among Anchorage-region residents, USA300 was a minor constituent among MRSA isolates in 2000–2003 (11/68, 16%); by 2006, USA300 was the exclusive genotype identified (10/10). PMID:22264651

75 FR 6397 - AMC USA, Inc. v. International First Service S.A. a/k/a IFS S.A, its Agents, Affiliated, Related...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-09

.../k/a IFS S.A, its Agents, Affiliated, Related and Partner Companies, and International First Service Argentina a/k/a AR-IFS, its Agents, Affiliated, Related and Partner Companies, and International First Service USA, Inc. a/k/a IFS USA, Inc. d/b/a Global Wine Logistics USA Inc. a/k/a GWL USA, Inc., and Global...

Formation and Decay of the Inner Electron Radiation Belt

DTIC Science & Technology

2017-01-09

Colorado Boulder, Boulder, Colorado, USA, 4NASA/Goddard Space Flight Center, Greenbelt, Maryland, USA, 5Department of Physics and Astronomy , Dartmouth...Colorado Boulder, Boulder, Colorado, USA, 4NASA Goddard Space Flight Center, Greenbelt, Maryland, USA, 5Department of Physics and Astronomy , Dartmouth

TLS and photogrammetry for the modeling of a historic wooden framework

NASA Astrophysics Data System (ADS)

Koehl, M.; Viale, M.

2012-04-01

The building which is the object of the study is located in the center of Andlau, France. This mansion that was built in 1582 was the residence of the Lords of Andlau from the XVIth century until the French Revolution. Its architecture represents the Renaissance style of the XVIth century in particular by its volutes and its spiral staircase inside the polygonal turret. In January 2005, the municipality of Andlau became the owner of this Seigneury which is intended to welcome the future Heritage Interpretation Center (HIC), a museum is also going to be created there. Three levels of attic of this building are going to be restored and isolated, the historic framework will that way be masked and the last three levels will not be accessible any more. In this context, our lab was asked to model the framework to allow to make diagnoses there, to learn to know and to consolidate the knowledge on this type of historic framework. Finally, next to a virtual visualization, we provided other applications in particular the creation of an accurate 3D model of the framework for animations, as well as for foundation of an historical information system and for supplying the future museum and HIC with digital data. The project contains different phases: the data acquisition, the model creation and data structuring, the creation of an interactive model and the integration in a historic information system. All levels of the attic were acquired: a 3D Trimble GX scanner and partially a Trimble CX scanner were used in particular for the acquisition of data in the highest part of the framework. The various scans were directly georeferenced in the field thanks to control points, then merged together in an unique point cloud covering the whole structure. Several panoramic photos were also realized to create a virtual tour of the framework and the surroundings of the Seigneury. The purpose of the project was to supply a 3D model allowing the creation of scenographies and interactive contents which will be integrated into an informative device. That way, the public can easily visualize the framework, manipulate the 3D model, discover the construction and the various parts of the historical wooden structure. The raw point cloud cannot be used for this kind of applications. It is thus necessary, from the data which it supplies, to create an exploitable model. Several parameters are to be taken into account: the level of detail of the 3D model, the necessary time to model all the beams, the weight of the final files and finally the type of applied texture. The idea was to implement a workflow to reconcile these various criteria, several methods were tested. This project allowed to create a range of solutions (3D models of the complete framework, virtual tour, interactive 3D models, video animations) to allow an uninitiated public to take advantage of 3D material and software often reserved for the professionals. The work was completed by the comparison between a theoretical model of the framework and a more detailed model of the current state, which allowed to make diagnoses and to study the movements of the structure in the time and to supply important data for rehabilitation and renovation operations.

78 FR 14400 - Southern USA Resources, Inc., Order of Suspension of Trading

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] Southern USA Resources, Inc., Order of... lack of current and accurate information concerning the securities of Southern USA Resources, Inc. (``Southern USA'') because of questions regarding the accuracy of publicly-disseminated information concerning...

Comprehensive Osteopathic Medical Licensing Examination-USA level 1 and level 2-cognitive evaluation preparation and outcomes.

PubMed

Maholtz, Danielle E; Erickson, Michael J; Cymet, Tyler

2015-04-01

The Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) assesses the competence of osteopathic physicians in training. It is designed to protect the public by setting minimum competence standards. All osteopathic medical students must pass COMLEX-USA Level 1, Level 2-Cognitive Evaluation, and Level 2-Performance Evaluation before being allowed to graduate from an osteopathic medical school. Residency training programs use COMLEX-USA scores as a major factor in deciding whom they will interview and admit into their programs. In addition, colleges of osteopathic medicine use student COMLEX-USA scores as an external assessment of their success in educating students. Because COMLEX-USA is a high-stakes examination series, it is important to understand predictive factors for performance. The authors review the literature on the relationship between COMLEX-USA scores and correlated student variables. Results from the Council on Osteopathic Student Government Presidents' survey on students' preparation methods and performance are also provided.

Kondo Effect in Dirac Systems

NASA Astrophysics Data System (ADS)

Yanagisawa, Takashi

2015-07-01

We investigate the Kondo effect in Dirac systems, where Dirac electrons interact with the localized spin via the s-d exchange coupling. The Dirac electron in solid state has the linear dispersion and is described typically by the Hamiltonian such as Hk = vk · σ for the wave number k where σj are Pauli matrices. We derived the formula of the Kondo temperature TK by means of the Green's function theory for small J. The TK is determined from a singularity of Green's functions in the form TK ≃ bar{D}exp ( - const./ρ |J|) when the exchange coupling |J| is small where bar{D} = D/√{1 + D2/(2μ )2} for a cutoff D and ρ is the density of states at the Fermi surface. When |μ| ≪ D, TK is proportional to |μ|: TK ≃ |μ| exp(-const./ρ|J|). The Kondo screening will, however, disappear when the Fermi surface shrinks to a point called the Dirac point, that is, TK vanishes when the chemical potential μ is just at the Dirac point. The resistivity and the specific heat exhibit a log-T singularity in the range TK < T ≪ |μ|/kB. Instead, for T ˜ O(|μ|) or T > |μ|, they never show log-T.

SPECTRE (www.noveltis.fr/spectre): a web Service for Ionospheric Products

NASA Astrophysics Data System (ADS)

Jeansou, E.; Crespon, F.; Garcia, R.; Helbert, J.; Moreaux, G.; Lognonne, P.

2005-12-01

The dense GPS networks developed for geodesic applications appear to be very efficient ionospheric sensors because of interaction between plasma and electromagnetic waves. Indeed, the dual frequency receivers provide data from which the Slant Total Electron Content (STEC) can be easily extracted to compute Vertical Total Electron Content (VTEC) maps. The SPECTRE project, Service and Products for ionospheric Electron Content and Tropospheric Refractivity over Europe, is currently a pre-operational service providing VTEC maps with high time and space resolution after 3 days time delay (http://www.noveltis.fr/spectre and http://ganymede.ipgp.jussieu.fr/spectre). This project is a part of SWENET, SpaceWeather European Network, initiated by the European Space Agency. The SPECTRE data products are useful for many applications. We will present these applications in term of interest for the scientific community with a special focus on spaceweather and transient ionospheric perturbations related to Earthquakes. Moreover, the pre-operational extensions of SPECTRE to the californian (SCIGN/BARD) and japanese (GEONET) dense GPS networks will be presented. Then the method of 3D tomography of the electron density from GPS data will be presented and its resolution discussed. The expected improvements of the 3D tomographic images by new tomographic reconstruction algorithms and by the advent of the Galileo system will conclude the presentation.

Evaluation of a transvaginal mesh delivery system for the correction of pelvic organ prolapse: subjective and objective findings at least 1 year after surgery.

PubMed

Culligan, Patrick J; Littman, Paul M; Salamon, Charbel G; Priestley, Jennifer L; Shariati, Amir

2010-11-01

We sought to track objective and subjective outcomes ≥1 year after transvaginal mesh system to correct prolapse. This was a retrospective cohort study of 120 women who received a transvaginal mesh procedure (Avaulta Solo, CR Bard Inc, Covington, GA). Outcomes were pelvic organ prolapse quantification values; Pelvic Floor Distress Inventory, Short Form 20/Pelvic Floor Impact Questionnaire, Short Form 7 scores; and a surgical satisfaction survey. "Surgical failure" was defined as pelvic organ prolapse quantification point >0, and/or any reports of vaginal bulge. Of 120 patients, 116 (97%) were followed up for a mean of 14.4 months (range, 12-30). In all, 74 patients had only anterior mesh, 21 only posterior mesh, and 21 both meshes. Surgical cure rate was 81%. Surgical failure was more common if preoperative point C ≥+2 (35% vs 16%; P = .04). Mesh erosion and de novo pain occurred in 11.7% and 3.3%, respectively. Pelvic Floor Distress Inventory, Short Form 20/Pelvic Floor Impact Questionnaire, Short Form 7 scores improved (P < .01). Objective and subjective improvements occurred at ≥1 year, yet failure rates were high when preoperative point C was ≥+2. Copyright © 2010 Mosby, Inc. All rights reserved.

Electron flow in large metallomacromolecules and electronic switch of nanoparticle stabilization: new click ferrocenyl dentromers that reduce Au(III) to Au nanoparticles.

PubMed

Astruc, Didier; Wang, Qi; Fu, Fangyu; Martinez-Villacorta, Angel M; Moya, Sergio; Salmon, Lionel; Ruiz, Jaime; Hunel, Julien; Vax, Amélie

2018-06-04

Click ferrocenyl-terminal dentromers, a family of arene-cored dendrimers with triple branching (9-Fc, 27-Fc, 81-Fc and 243-Fc) reduce Au(III) to ferricinium dentromer-stabilized Au nanoparticles (AuNPs). Cyclic voltammetry studies in CH2Cl2 show reversible CV waves with some adsorption for the 243-Fc dentromer and a number of redox groups found, 255 ± 25, using the Bard-Anson method, close to the theoretical number of 243. The dentromers reduce aqueous HAuCl4 to water-soluble ferricinium chloride dentromer-stabilized gold nanoparticles (AuNPs) with core sizes between 30 and 47 nm. These triazolylferricinium dentromer-stabilized AuNPs are reduced by cobaltocene to cobalticinium chloride and ferrocene dentromer-weakly stabilized AuNPs together with red shift of the AuNP plasmon. The weakness of the AuNP stabilization is characterized by dentromer extraction with CH2Cl2 along with irreversible AuNP agglomeration for the 9, 27 and 81-ferrocenyl dentromer, only the 243-ferrocenyl dentromer-AuNP withstanding this process. Altogether this demonstrates the electronic switch of the dentromer-mediated AuNP stabilization. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

What if Astyanax had survived? War, children, and youth.

PubMed

Allen, J R; Pfefferbaum, B

1998-01-01

What, then, might have happened to Astyanax had he survived? He might have become a Greek slave and accepted his lot, or he might have felt loyalty and an obligation to his Trojan ancestry and organized acts of revenge. Depending on his personal characteristics and the people and the community that raised him, a number of outcomes are possible. The fact that after 3000 years we know little more than did the Homeric bards, however, gives us reason to be humble. There is evidence that each experience of loss or violence is additive and reduces coping ability. Although the psychologic disturbances of children and youth exposed to war do appear less intense than might have been expected, as Garmezy and Rutter noted in 1985, it is impossible to know the cost, the vulnerabilities that have been veiled, and what might have been. Perhaps the most remarkable thing is how some children seem able to transcend their misfortunes and even to be steeled by them. Coles has recorded how a 6-year-old, African-American girl, initiating school desegregation in New Orleans in the face of mob violence and daily threats to her life, told him that if she managed to get through with some success, she had an explanation: "It will be because there is more to me than I ever realized."

78 FR 25304 - Siemens Medical Solutions, USA, Inc., Oncology Care Systems (Radiation Oncology), Including On...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

..., USA, Inc., Oncology Care Systems (Radiation Oncology), Including On-Site Leased Workers From Source... Medical Solutions, USA, Inc., Oncology Care Systems (Radiation Oncology), including on- site leased... of February 2013, Siemens Medical Solutions, USA, Inc., Oncology Care Systems (Radiation Oncology...

Updates from the Neuro-Oncology Section of the 2015 American Neurological Association Annual Meeting.

PubMed

Lukas, Rimas V; Wainwright, Derek A; Laterra, John J

2016-01-01

American Neurological Association Annual Meeting, Chicago, IL, USA, 27-29 September 2015 The American Neurological Association (ANA) held its annual meeting in Chicago, IL, USA on 27-29 September 2015. The Scientific Programming Advisory Committee was chaired by Dr. S Pleasure from the University of California-San Francisco (CA, USA). The Neuro-Oncology session, chaired by Dr. A Pruitt from the University of Pennsylvania (PA, USA) and cochaired by Dr. J Laterra from Johns Hopkins University (MD, USA), was held on 27 September 2015. Speakers included Dr. D Wainwright (Northwestern University, IL, USA), Dr. N Kolb (University of Utah, UT, USA), Dr. A Nath (NINDS/NIH, MD, USA), Dr. D Franz (Cincinnati Children's Hospital, OH, USA) and Dr. R Lukas (University of Chicago, IL, USA). A summary of key presentations from the Neuro-Oncology section of the 2015 American Neurological Association annual meeting is reported. Preclinical and clinical advances in the use of immunotherapies for the treatment of primary and metastatic CNS tumors are covered. Particular attention is paid to the enzyme indoleamine dioxygenase and the immune checkpoints CTLA4 and PD1 and their ligands. Specific nervous system toxicities associated with novel immunotherapies are also discussed. The recent success of targeting the mTOR pathway in the neurocutaneous syndrome tuberous sclerosis is detailed. Finally, important early steps in our understanding of the common toxicity of chemotherapy induced neuropathy are reviewed.

Risk of Skin and Soft Tissue Infections among Children Found to be Staphylococcus aureus MRSA USA300 Carriers

PubMed Central

Immergluck, Lilly Cheng; Jain, Shabnam; Ray, Susan M.; Mayberry, Robert; Satola, Sarah; Parker, Trisha Chan; Yuan, Keming; Mohammed, Anaam; Jerris, Robert C.

2017-01-01

Introduction The purpose of this study was to examine community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) carriage and infections and determine risk factors associated specifically with MRSA USA300. Methods We conducted a case control study in a pediatric emergency department. Nasal and axillary swabs were collected, and participants were interviewed for risk factors. The primary outcome was the proportion of S. aureus carriers among those presenting with and without a skin and soft tissue infection (SSTI). We further categorized S. aureus carriers into MRSA USA300 carriers or non-MRSA USA300 carriers. Results We found the MRSA USA300 carriage rate was higher in children less than two years of age, those with an SSTI, children with recent antibiotic use, and those with a family history of SSTI. MRSA USA300 carriers were also more likely to have lower income compared to non-MRSA USA300 carriers and no S. aureus carriers. Rates of Panton-Valentine leukocidin (PVL) genes were higher in MRSA carriage isolates with an SSTI, compared to MRSA carriage isolates of patients without an SSTI. There was an association between MRSA USA300 carriage and presence of PVL in those diagnosed with an abscess. Conclusion Children younger than two years were at highest risk for MRSA USA300 carriage. Lower income, recent antibiotic use, and previous or family history of SSTI were risk factors for MRSA USA300 carriage. There is a high association between MRSA USA300 nasal/axillary carriage and presence of PVL in those with abscesses. PMID:28210352

28 CFR 16.81 - Exemption of United States Attorneys Systems-limited access.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Systems-limited access. 16.81 Section 16.81 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR... (g): (1) Citizen Complaint Files (JUSTICE/USA-003). (2) Civil Case Files (JUSTICE/USA-005). (3) Consumer Complaints (JUSTICE/USA-006). (4) Criminal Case Files (JUSTICE/USA-007). (5) Kline-District of...

76 FR 35715 - Establishment of the SelectUSA Initiative

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... Establishment of the SelectUSA Initiative By the authority vested in me as President by the Constitution and the... unnecessary obstacles to investment. Sec. 2. SelectUSA Initiative. (a) Establishment. There is established the SelectUSA Initiative (Initiative), a Government-wide initiative to attract and retain investment in the...

The Science and Technologies for Fusion Energy With Lasers and Direct-Drive Targets

DTIC Science & Technology

2010-04-01

Commonwealth Technology, Inc ., Alexandria, VA 22315 USA. A. Bayramian, J. Caird, C. Ebbers, J. Latkowski, W. Hogan, W. R. Meier, L. J. Perkins, and K...USA. M. W. McGeoch is with PLEX Corporation, Brookline, MA 02146 USA. S. C. Glidden and H. Sanders are with Applied Pulsed Power, Inc ., Freeville, NY...13068-0348 USA. D. Weidenheimer, D. Morton, and I. D. Smith are with L3 Pulse Sciences, Inc ., San Leandro, CA 94577-5602 USA. M. Bobecia and D. Harding

Airborne surveys of USA urban areas at 121.5/243 MHz

NASA Technical Reports Server (NTRS)

Taylor, R. E.; Hill, J. S.

1979-01-01

In situ, aircraft flight measurements were made in 1976 and 1977 by NASA of the radio-frequency environment over USA urban areas within the emergency distress search and rescue frequency bands at 121.5 and 243.0 MHz. This paper analyzes test results reported previously for USA East Coast and Midwest flight surveys; presented also are test results obtained in May 1977 for the USA West Coast during the NASA, ASSESS-II, Space Shuttle/Spacelab simulation aircraft flights. The USA West Coast flight include data at 121.5/243 MHz during an extensive series of aircraft passes for the Los Angeles urban area. The USA East Coast/Midwest measurements show correlation with population count.

DNA damage and external lesions in brown bullheads (Ameiurus nebulosus) from contaminated habitats

USGS Publications Warehouse

Yang, X.; Meier, J.; Chang, L.; Rowan, M.; Baumann, P.C.

2006-01-01

The Comet assay was used to compare levels of DNA damage in brown bullheads (Ameiurus nebulosus) collected from three known contaminated locations, the Cuyahoga River (OH, USA), Ashtabula River (OH, USA; both tributaries to Lake Erie, USA), and Ashumet Pond (Cape Cod, MA, USA), with brown bullheads collected from three paired reference sites, Old Woman Creek (OH, USA), Conneaut River (OH, USA; both tributaries to Lake Erie), and Great Herring Pond (mainland MA, USA), respectively. Blood was sampled from each fish, and the Comet assay was conducted on erythrocytes. The assay results demonstrate that fish from the three contaminated sites each suffered higher DNA damage compared with fish from their respective reference sites. The results also show that the genetic damage was associated with the occurrence of external lesions and deformities in fish. The Comet assay is sufficiently sensitive to detect exposure of natural fish populations to environmental levels of genotoxic contaminants. ?? 2006 SETAC.

Controlling imported malaria cases in the United States of America.

PubMed

Dembele, Bassidy; Yakubu, Abdul-Aziz

2017-02-01

We extend the mathematical malaria epidemic model framework of Dembele et al. and use it to ``capture" the 2013 Centers for Disease Control and Prevention (CDC) reported data on the 2011 number of imported malaria cases in the USA. Furthermore, we use our ``fitted" malaria models for the top 20 countries of malaria acquisition by USA residents to study the impact of protecting USA residents from malaria infection when they travel to malaria endemic areas, the impact of protecting residents of malaria endemic regions from mosquito bites and the impact of killing mosquitoes in those endemic areas on the CDC number of imported malaria cases in USA. To significantly reduce the number of imported malaria cases in USA, for each top 20 country of malaria acquisition by USA travelers, we compute the optimal proportion of USA international travelers that must be protected against malaria infection and the optimal proportion of mosquitoes that must be killed.

76 FR 40714 - Decision and Order Granting a Waiver to Mitsubishi Electric & Electronics USA, Inc. From the...

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2011-07-11

... and Order Granting a Waiver to Mitsubishi Electric & Electronics USA, Inc. From the Department of... Mitsubishi Electric & Electronics USA, Inc. (Mitsubishi) a waiver from the existing DOE test procedures... Matter of: Mitsubishi Electric & Electronics USA, Inc. (Mitsubishi) (Case No. CAC-030). Background Title...

76 FR 50269 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

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2011-08-12

... Solutions USA, Inc., Oncology Care Systems Division, Concord, CA TA-W-73,158A Siemens Medical Solutions USA... and former workers of Siemens Medical Solutions USA, Inc. (Seimens), Oncology Care Systems Division... issued as follows: All workers of Siemens Medical Solutions USA, Inc., Oncology Care Systems Division...

78 FR 30333 - Manufacturer of Controlled Substances; Notice of Registration; Siegfried (Usa), Llc.

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2013-05-22

...; Notice of Registration; Siegfried (Usa), Llc. By Notice dated November 19, 2012, and published in the Federal Register on November 27, 2012, 77 FR 70825, Siegfried (USA), LLC., 33 Industrial Park Road... 21 U.S.C. 823(a) and determined that the registration of Siegfried (USA), LLC., to manufacture the...

77 FR 30027 - Manufacturer of Controlled Substances; Notice of Registration; Siegfried (USA)

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2012-05-21

...; Notice of Registration; Siegfried (USA) By Notice dated January 6, 2012, and published in the Federal Register on January 17, 2012, 77 FR 2323, Siegfried (USA), 33 Industrial Park Road, Pennsville, New Jersey... U.S.C. 823(a) and determined that the registration of Siegfried (USA), to manufacture the listed...

78 FR 64020 - Manufacturer of Controlled Substances, Notice of Registration, Siegfried USA, LLC

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2013-10-25

..., Notice of Registration, Siegfried USA, LLC The Notice dated July 23, 2013, and published in the Federal Register on August 1, 2013, 78 FR 46613, page 18338, Siegfried (USA), LLC., 33 Industrial Park Road...), and Poppy Straw Concentrate (9670). On August 6, 2013, Siegfried (USA), LLC., subsequently withdrew...

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2011-01-03

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2012-12-26

... CONSUMER PRODUCT SAFETY COMMISSION [CPSC Docket No. 13-2] Star Networks USA, LLC; Complaint AGENCY.... Published below is a Complaint: In the Matter of Star Networks USA, LLC.\\1\\ \\1\\ Chairman Inez M. Tenenbaum... COMMISSION In the Matter of STAR NETWORKS USA, LLC, Respondent CPSC DOCKET NO. 13-2 COMPLAINT Nature of...

76 FR 29257 - Accreditation of Intertek USA, Inc., as a Commercial Laboratory

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2011-05-20

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Accreditation of Intertek USA... Security. ACTION: Notice of accreditation of Intertek USA, Inc., as a commercial laboratory. SUMMARY: Notice is hereby given that, pursuant to 19 CFR 151.12, Intertek USA, Inc., 8500 West Bay Road MS 37...

77 FR 75183 - Approval of Intertek USA, Inc., as a Commercial Gauger

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2012-12-19

... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Approval of Intertek USA, Inc.... ACTION: Notice of approval of Intertek USA, Inc., as a commercial gauger. SUMMARY: Notice is hereby given that, pursuant to 19 CFR 151.13, Intertek USA, Inc., 139 Castle Coakley, Suite 8, St. Croix, VI 00820...

GLIMPSE: A GCAM-USA-based tool for supporting coordinated energy and environmental planning

EPA Science Inventory

GCAM-USA is an integrated assessment model, meaning that it simulates the interactions among human and earth systems. GCAM-USA is derived from GCAM, which represents the U.S. as one region within a 32-region global model. GCAM-USA subdivides the U.S. region into 50 states and the...

Dynamic interactions of proteins in complex networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Appella, E.; Anderson, C.

2009-10-01

Recent advances in techniques such as NMR and EPR spectroscopy have enabled the elucidation of how proteins undergo structural changes to act in concert in complex networks. The three minireviews in this series highlight current findings and the capabilities of new methodologies for unraveling the dynamic changes controlling diverse cellular functions. They represent a sampling of the cutting-edge research presented at the 17th Meeting of Methods in Protein Structure Analysis, MPSA2008, in Sapporo, Japan, 26-29 August, 2008 (http://www.iapsap.bnl.gov). The first minireview, by Christensen and Klevit, reports on a structure-based yeast two-hybrid method for identifying E2 ubiquitin-conjugating enzymes that interact withmore » the E3 BRCA1/BARD1 heterodimer ligase to generate either mono- or polyubiquitinated products. This method demonstrated for the first time that the BRCA1/BARD1 E3 can interact with 10 different E2 enzymes. Interestingly, the interaction with multiple E2 enzymes displayed unique ubiquitin-transfer properties, a feature expected to be common among other RING and U-box E3s. Further characterization of new E3 ligases and the E2 enzymes that interact with them will greatly enhance our understanding of ubiquitin transfer and facilitate studies of roles of ubiquitin and ubiquitin-like proteins in protein processing and trafficking. Stein et al., in the second minireview, describe recent progress in defining the binding specificity of different peptide-binding domains. The authors clearly point out that transient peptide interactions mediated by both post-translational modifications and disordered regions ensure a high level of specificity. They postulate that a regulatory code may dictate the number of combinations of domains and post-translational modifications needed to achieve the required level of interaction specificity. Moreover, recognition alone is not enough to obtain a stable complex, especially in a complex cellular environment. Increasing evidence indicates that disordered domains can acquire structural features that modulate the binding and strength of the signaling cascade. Whereas the first two minireviews describe ways in which protein interactions are modulated, the third, by Tompa, focuses on the importance of protein disorder in a subset of amyloid proteins. It is apparent that within this group, part of the polypeptide chain remains disordered during amyloid formation. Moreover, the disordered segments have different amino acid composition and physicochemical characteristics, which suggests that they may play a role in amyloid stability. The disordered region may serve as a linker to connect the ordered core and a globular domain, maintaining the stability and structure of the globular domain and minimizing protein refolding upon amyloid formation. As techniques in protein chemistry advance, we are learning more and more about the mechanisms that regulate and are regulated by protein interactions. The three minireviews in this series offer a glimpse of the complex dynamics fundamental to protein-protein interactions. In the future, we expect that the knowledge gained will help to augment our ability to control complex pathologies and treat diverse diseases states.« less

Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8

PubMed Central

Strauß, Lena; Alabi, Abraham; Breurec, Sebastien; Coombs, Geoffrey; Egyir, Beverly; Larsen, Anders Rhod; Laurent, Frederic; Monecke, Stefan; Peters, Georg; Skov, Robert; Strommenger, Birgit; Schaumburg, Frieder

2017-01-01

USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary origin of USA300 remained unclear. We used comparative genomics of 224 temporal and spatial diverse S. aureus isolates of multilocus sequence type (ST) 8 to reconstruct the molecular evolution and global dissemination of ST8, including USA300. Analyses of core SNP diversity and accessory genome variations showed that the ancestor of all ST8 S. aureus most likely emerged in Central Europe in the mid-19th century. From here, ST8 was exported to North America in the early 20th century and progressively acquired the USA300 characteristics Panton–Valentine leukocidin (PVL), SCCmec IVa, the arginine catabolic mobile element (ACME), and a specific mutation in capsular polysaccharide gene cap5E. Although the PVL-encoding phage ϕSa2USA was introduced into the ST8 background only once, various SCCmec types were introduced to ST8 at different times and places. Starting from North America, USA300 spread globally, including Africa. African USA300 isolates have aberrant spa-types (t112, t121) and form a monophyletic group within the clade of North American USA300. Large parts of ST8 methicillin-susceptible S. aureus (MSSA) isolated in Africa represent a symplesiomorphic group of ST8 (i.e., a group representing the characteristics of the ancestor), which are rarely found in other world regions. Isolates previously discussed as USA300 ancestors, including USA500 and a “historic” CA-MRSA from Western Australia, were shown to be only distantly related to recent USA300 clones. PMID:29158405

Neurological deaths of American adults (55-74) and the over 75's by sex compared with 20 Western countries 1989-2010: Cause for concern.

PubMed

Pritchard, Colin; Rosenorn-Lanng, Emily

2015-01-01

Have USA total neurological deaths (TNDs) of adults (55-74) and the over 75's risen more than in twenty Western Countries? World Health Organization TND data are compared with control mortalities cancer mortality rates (CMRs) and circulatory disease deaths (CDDs) between 1989-1991 and 2008-2010 and odds ratios (ORs) and confidence intervals calculated. Neurological Deaths - Twenty country (TC) average 55-74 male rates per million (pm) rose 2% to 503 pm, USA increased by 82% to 627 pm. TC average females rose 1% to 390 pm, USA rising 48% to 560 pm. TC average over 75's male and female increased 117% and 143%; USA rising 368% and 663%, significantly more than 16 countries. Cancer mortality - Average 55-74 male and female fell 20% and 12%, USA down 36% and 18%. TC average over 75's male and female fell 13% and 15%, the USA 29% and 2%. Circulatory deaths - TC average 55-74 rates fell 60% and 46% the USA down 54% and 53%. Over 75's average down 46% and 39%, USA falling 40% and 33%. ORs for rose substantially in every country. TC average 75's ORs for CMR: TND male and females were 1:2.83 and 1:3.04 but the USA 1:5.18 and 1:6.50. The ORs for CDD: TND male and females TC average was 1:3.42 and 1:3.62 but the USA 1:6.13 and 1:9.89. Every country's neurological deaths rose relative to the controls, especially in the USA, which is a cause for concern and suggests possible environmental influences.

78 FR 64020 - Manufacturer of Controlled Substances; Notice of Registration; Siegfried USA, LLC

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2013-10-25

...; Notice of Registration; Siegfried USA, LLC By Notice dated May 22, 2013, and published in the Federal Register on May 30, 2013, 78 FR 32458, Siegfried USA, LLC., 33 Industrial Park Road, Pennsville, New Jersey... determined that the registration of Siegfried USA, LLC., to manufacture the listed basic class of controlled...

75 FR 39550 - Accreditation and Approval of Intertek USA, Inc., as a Commercial Gauger and Laboratory

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2010-07-09

... Intertek USA, Inc., as a Commercial Gauger and Laboratory AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of Intertek USA, Inc., as a... 151.13, Intertek USA, Inc., 116 Bryan Road Suite 101, Wilmington, NC 28412, has been approved to gauge...

76 FR 37135 - Accreditation and Approval of Intertek USA, Inc., as a Commercial Gauger and Laboratory

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2011-06-24

... Intertek USA, Inc., as a Commercial Gauger and Laboratory AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION: Notice of accreditation and approval of Intertek USA, Inc., as a... 151.13, Intertek USA, Inc., 4398 Highway 77 N, Marion, AR 72364, has been approved to gauge and...

Age at onset in bipolar I affective disorder in the USA and Europe.

PubMed

Bellivier, Frank; Etain, Bruno; Malafosse, Alain; Henry, Chantal; Kahn, Jean-Pierre; Elgrabli-Wajsbrot, Orly; Jamain, Stéphane; Azorin, Jean-Michel; Frank, Ellen; Scott, Jan; Grochocinski, Victoria; Kupfer, David J; Golmard, Jean-Louis; Leboyer, Marion

2014-07-01

To test for differences in reported age at onset (AAO) of bipolar I affective disorder in clinical samples drawn from Europe and the USA. Admixture analysis was used to identify the model best fitting the observed AAO distributions of two large samples of bipolar I patients from Europe and USA (n = 3616 and n = 2275, respectively). Theoretical AAO functions were compared between the two samples. The model best fitting the observed distribution of AAO in both samples was a mixture of three Gaussian distributions. The theoretical AAO functions of bipolar I disorder differed significantly between the European and USA populations, with further analyses indicating that (i) the proportion of patients belonging to the early-onset subgroup was higher in the USA sample (63 vs. 25%) and (ii) mean age at onset (±SD) in the early-onset subgroup was lower for the USA sample (14.5 ± 4.9 vs. 19 ± 2.7 years). The models best describing the reported AAO distributions of European and USA bipolar I patients were remarkably stable. The intermediate- and late-onset subgroups had similar characteristics in the two samples. However, the theoretical AAO function differed significantly between the USA and European samples due to the higher proportion of patients in the early-onset subgroup and the lower mean age-at-onset in the USA sample.

76 FR 64330 - Notice of Petition for Waiver of LG Electronics U.S.A., Inc. From the Department of Energy...

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2011-10-18

... Petition for Waiver of LG Electronics U.S.A., Inc. From the Department of Energy Residential Clothes Washer... for comments. SUMMARY: This notice announces receipt of and publishes the LG Electronics U.S.A., Inc..., Government Relations and Communications, LG Electronics USA, Inc., 1776 K Street, NW., Washington, DC 20006...

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2011-11-16

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77 FR 55455 - Approval for Manufacturing Authority Foreign-Trade Zone 72, Brevini Wind USA, Inc., (Wind Turbine...

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2012-09-10

... Authority Foreign-Trade Zone 72, Brevini Wind USA, Inc., (Wind Turbine Gear Boxes), Yorktown, IN Pursuant to... Wind USA, Inc., within FTZ 72 in Yorktown, Indiana (FTZ Docket 54-2011, filed 8-11-2011); Whereas... procedures within FTZ 72 on behalf of Brevini Wind USA, Inc., as described in the application and Federal...

Homeschooling as an Alternative Form of Educational Provision in South Africa and the USA

ERIC Educational Resources Information Center

de Waal, Esther; Theron, Tinie

2003-01-01

This paper studies homeschooling as an alternative form of educational provision in South Africa and USA to determine what knowledge and experiences from research on homeschooling in the USA may be relevant to the South Africa situation. Homeschooling in the USA has a sound legal foundation and has become an acceptable educational alternative.…

KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

PREFACE Turbulent Mixing and Beyond

NASA Astrophysics Data System (ADS)

Abarzhi, Snezhana I.; Gauthier, Serge; Niemela, Joseph J.

2010-12-01

The goals of the International Conference 'Turbulent Mixing and Beyond', TMB-2009, are to expose the generic problem of non-equilibrium turbulent processes to a broad scientific community, to promote the development of new ideas in tackling the fundamental aspects of the problem, to assist in the application of novel approaches in a broad range of phenomena, where the turbulent processes occur, and to have a potential impact on technology. The Conference provides the opportunity to bring together researchers from different areas, which include but are not limited to fluid dynamics, plasmas, high energy density physics, astrophysics, material science, combustion, atmospheric and Earth sciences, nonlinear and statistical physics, applied mathematics, probability and statistics, data processing and computations, optics and telecommunications, and to have their attention focused on the long-standing formidable task of non-equilibrium processes. Non-equilibrium turbulent processes play a key role in a broad variety of phenomena spanning astrophysical to atomistic scales and high or low energy density regimes. Inertial confinement and magnetic fusion, light-matter interaction and non-equilibrium heat transfer, strong shocks and explosions, material transformation under high strain rate, supernovae and accretion disks, stellar non-Boussinesq and magneto-convection, planetary interiors and mantle-lithosphere tectonics, premixed and non-premixed combustion, non-canonical wall-bounded flows, hypersonic and supersonic boundary layers, dynamics of atmosphere and oceanography, are just a few examples. A grip on non-equilibrium turbulent processes is crucial for cutting-edge technology such as laser micro-machining, nano-electronics, free-space optical telecommunications, and for industrial applications in the areas of aeronautics and aerodynamics. Non-equilibrium turbulent processes are anisotropic, non-local, multi-scale and multi-phase, and often are driven by shocks or acceleration. Their scaling, spectral and invariant properties differ substantially from those of classical Kolmogorov turbulence. At atomistic and meso-scales, the non-equilibrium dynamics depart dramatically from a standard scenario given by the Gibbs statistic ensemble average and quasi-static Boltzmann equation. The singular aspect and the similarity of the non-equilibrium dynamics at macroscopic scales are interplayed with the fundamental properties of the Euler and compressible Navier-Stokes equations and with the problem sensitivity to the boundary conditions at discontinuities. The state-of-the-art numerical simulations of multi-phase flows suggest new methods for predictive modeling of the multi-scale non-equilibrium dynamics in fluids and plasmas, up to peta-scale level, for error estimate and uncertainty quantification, as well as for novel data assimilation techniques. The Second International Conference and Advanced School 'Turbulent Mixing and Beyond', TMB-2009, was held on 27 July-7 August 2009 at the Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy. This was a highly informative and exciting meeting, and it strengthened and reaffirmed the success of TMB-2007. TMB-2009 brought together over 180 participants from five continents, ranging from students to members of National Academies of Sciences and Engineering and including researchers at experienced and early stages of their carriers from leading scientific institutions in academia, national laboratories, corporations and industry, from developed and developing countries. The success of TMB-2009 came from the successful work of all the participants, who were responsible professionals caring for the quality of their research and sharing their scientific vision. The level of presentations was high; about 170 presentations included over 60 invited lectures and 15 tutorials (4500 minutes of talks in total), about 40 posters and two Round Tables. TMB-2009 covered 17 different topics, maintaining the scope and the interdisciplinary character of the meeting while keeping the focus on a fundamental scientific problem of non-equilibrium processes and on the Conference objectives. The abstracts of the 194 accepted presentations of more than 400 authors were published in the Book of Abstracts of the Second International Conference and Advanced School 'Turbulent Mixing and Beyond', 27 July-7 August 2009 , Copyright © 2009, the Abdus Salam International Centre for Theoretical Physics, Trieste, Italy (ISBN 92095003-41-1). This Topical Issue consists of 70 articles accepted for publication in the Conference Proceedings and represents a substantial part of the Conference contributions. The articles are in a broad variety of TMB-2009 themes and are sorted alphabetically by the last name of the first author within each of the following topics: Canonical turbulence and turbulent mixing: invariant, scaling, spectral properties, scalar transports, convection; Wall-bounded flows: structure and fundamentals, non-canonical turbulent boundary layers, including unsteady and transitional flows, supersonic and hypersonic flows, shock-boundary layer interactions; Non-equilibrium processes: unsteady, multiphase and shock-driven turbulent flows, anisotropic non-local dynamics, connection of continuous description at macro-scales to kinetic processes at atomistic scales; Interfacial dynamics: instabilities of Rayleigh-Taylor, Kelvin-Helmholtz, Richtmyer-Meshkov, Landau-Darrieus, Saffman-Taylor High energy density physics: inertial confinement and heavy-ion fusion, Z-pinches, light-matter and laser-plasma interactions, non-equilibrium heat transfer; Material science: material transformation under high strain rates, equation of state, impact dynamics, mixing at nano- and micro-scales; Astrophysics: supernovae, interstellar medium, star formation, stellar interiors, early Universe, cosmic-microwave background, accretion disks; Magneto-hydrodynamics: magnetic fusion and magnetically confined plasmas, magneto-convection, magneto-rotational instability, dynamo; Canonical plasmas: coupled plasmas, anomalous resistance, ionosphere; Physics of atmosphere: environmental fluid dynamics, weather forecasting, turbulent flows in stratified media and atmosphere, non-Boussinesq convection; Geophysics and Earth science: mantle-lithosphere tectonics, oceanography, turbulent convection under rotation, planetary interiors; Combustion: dynamics of flames and fires, deflagration-to-detonation transition, blast waves and explosions, flows with chemical reactions, flows in jet engines; Mathematical aspects of non-equilibrium dynamics: vortex dynamics, singularities, discontinuities, asymptotic dynamics, weak solutions, well- and ill-posedness, continuous transports out of thermodynamic equilibrium; Stochastic processes and probabilistic description: long-tail distributions and anomalous diffusion, data assimilation and processing methodologies, error estimate and uncertainty quantification, statistically unsteady processes; Advanced numerical simulations: continuous DNS/LES/RANS, molecular dynamics, Monte-Carlo, predictive modeling, validation and verification of numerical models; Experimental diagnostics: model experiments in high energy density and low energy density regimes, plasma diagnostics, fluid flow visualizations and control, opto-fluidics, novel optical methods, holography, advanced technologies. TMB-2009 was organized by the following members of the Organizing Committee: Snezhana I Abarzhi (chairperson, Chicago, USA) Malcolm J Andrews (Los Alamos National Laboratory, USA) Sergei I Anisimov (Landau Institute for Theoretical Physics, Russia) Hiroshi Azechi (Institute of Laser Engineering, Osaka, Japan) Serge Gauthier (Commissariat à l'Energie Atomique, France) Christopher J Keane (Lawrence Livermore National Laboratory, USA) Robert Rosner (Argonne National Laboratory, USA) Katepalli R Sreenivasan (International Centre for Theoretical Physics, Italy) Alexander L Velikovich (Naval Research Laboratory, USA) and the Local Organizing Committee at the International Centre for Theoretical Physics, Italy Joseph J Niemela Katepalli R Sreenivasan with the assistance of Suzie Radosic (administrator and assistant, ICTP) Daniil Ilyin (web-master, University of Chicago Laboratory Schools, Chicago, USA) The Conference and the School were sponsored by several Agencies and Institutions in the USA, Europe and Japan. The Organizing Committee of TMB-2009 gratefully acknowledges the support of International Centre for Theoretical Physics (ICTP), Italy National Science Foundation (NSF), USA Programs: Plasma Physics; Astronomy and Astrophysics; Computational Mathematics; Applied Mathematics; Fluid Dynamics; Combustion, Fire and Plasma Systems; Cyber-Physical Systems; Computer and Network Systems Air Force Office of Scientific Research (AFOSR), US Programs: Hypersonics and Turbulence; Flow Control and Aeroelasticity European Office of Aerospace Research and Development (EOARD) of the AFOSR, UK Programs: Aeronautical Sciences Department of Energy (DOE), USA, DOE Office of Science US Department of Energy Lawrence Livermore National Laboratory (LLNL), USA Programs: National Ignition Facility; Fusion Energy US Department of Energy Los Alamos National Laboratory (LANL), USA US Department of Energy Argonne National Laboratory (ANL), USA Commissariat à l'Energie Atomique (CEA), France Institute for Laser Engineering (ILE), Japan The University of Chicago, USA ASC Alliance Center for Astrophysical Thermonuclear Flashes, USA Photron (Europe) Ltd, UK and thank them for making this event possible. We express our gratitude for the help with the Conference Program to the members of the Scientific Advisory Committee: S I Abarzhi (University of Chicago, USA) Y Aglitskiy (Science Applications International Corporation, USA) H Azechi (Institute for Laser Engineering, Osaka, Japan) M J Andrews (Los Alamos National Laboratory, USA) S I Anisimov (Landau Institute for Theoretical Physics, Russia) E Bodenschatz (Max Plank Institute for Dynamics and Self-Organization, Germany) F Cattaneo (University of Chicago, USA) P Cvitanović (Georgia Institute of Technology, USA) S Cowley (Imperial College, UK) S Dalziel (DAMTP, University of Cambridge, UK) W S Don (Brown University, USA) R Ecke (Los Alamos National Laboratory, USA) H J Fernando (Arizona State University, USA) I Foster (University of Chicago, USA) S Gauthier (Commissariat à l'Energie Atomique, France) G A Glatzmaier (University of California at Santa Cruz, USA) J Glimm (State University of New York at Stony Brook, USA) W A Goddard III (California Institute of Technology, USA) J Jimenez (Universidad Politecnica de Madrid, Spain) L P Kadanoff (The University of Chicago, USA) D Q Lamb (The University of Chicago, USA) D P Lathrop (University of Maryland, USA) S Lebedev (Imperial College, UK) P Manneville (École Polytechnique, France) D I Meiron (California Institute of Technology, USA) P Moin (Stanford University, USA) A Nepomnyashchy (Technion, Israel) J Niemela (International Center for Theoretical Physics, Italy) K Nishihara (Institute for Laser Engineering, Osaka, Japan) S S Orlov (Stanford University, USA) S A Orszag (Yale University, USA) E Ott (University of Maryland, USA) N Peters (RWTH Aachen University, Germany) S B Pope (Cornell, USA) A Pouquet (University Corporation for Atmospheric Research, USA) B A Remington (Lawrence Livermore National Laboratory, USA) R Rosner (Argonne National Laboratory and University of Chicago, USA) A J Schmitt (Naval Research Laboratory, USA) C -W Shu (Brown University, USA) K R Sreenivasan (International Centre for Theoretical Physics, Italy) E Tadmor (University of Maryland, USA) Y C F Thio (US Department of Energy) A L Velikovich (Naval Research Laboratory, USA) V Yakhot (Boston University, USA) P K Yeung (Georgia Institute of Technology, USA) F A Williams (University of California at San Diego, USA) E Zweibel (University of Wisconsin, USA). We deeply appreciate the work of the Selection Committee for applications for the Advanced School: S Gauthier (Commissariat à l'Energie Atomique, France) C J Keane (Lawrence Livermore National Laboratory, USA) J Niemela (International Center for Theoretical Physics, Italy) S S Orlov (Stanford University, USA) A L Velikovich (Naval Research Laboratory, USA) and thank the members of the Committee for the award 'Turbulent Mixing and Beyond for Youth': S I Abarzhi (University of Chicago, USA) M J Andrews (Los Alamos National Laboratory, USA) P Cvitanović (Georgia Institute of Technology, USA) S Gauthier (Commissariat à l'Energie Atomique, France) C J Keane (Lawrence Livermore National Laboratory, USA) S Lebedev (Imperial College, UK) J Niemela (International Center for Theoretical Physics, Italy) S S Orlov (Stanford University, USA) A Pouquet (University Corporation for Atmospheric Research, USA) K R Sreenivasan (International Centre for Theoretical Physics, Italy) A L Velikovich (Naval Research Laboratory, USA) We would like to thank all the authors and the referees for their contributions to this Topical Issue and for offering their expertise, time and effort. The readers are cordially invited to take a look at this Topical Issue for information on the frontiers of theoretical, numerical and experimental research, and state-of-the-art technology. The Organizing Committee hopes the TMB Conference will serve to advance the state-of-the-art in understanding of fundamental physical properties of non-equilibrium turbulent processes and will have an impact on predictive modeling capabilities, physical description and, ultimately, control of these complex processes. Welcome to the Topical Issue 'Turbulent Mixing and Beyond', TMB-2009.

Arab American Parents' Perceptions of Their Children's Experience in the USA: A Qualitative Study

ERIC Educational Resources Information Center

Ahmad, Jamal

2017-01-01

The purpose of this study was to examine Arab American parents' perceptions of difficulties their children experience in the USA. Both Arab American children born outside the USA who later moved to the country and children born in the USA to Arab parents were examined. Fifty Arab American families were interviewed in two areas in the State of…

Interferometry of Epsilon Aurigae: Characterization of the Asymmetric Eclipsing Disk

DTIC Science & Technology

2015-09-21

Observatory, Mount Wilson, California 91023, USA; bkloppenborg@chara.gsu.edu 2 Department of Physics & Astronomy, University of Denver, Denver, CO...80208 USA 3 Department of Astronomy, University of Michigan, 941 Dennison Building, Ann Arbor, Michigan 48109, USA 4 Department of Physics , Central...Observatory Road, Flagstaff, Arizona 86001, USA 6 Department of Physics and Astronomy, Penn. State, University Park, PA 16802 7 School of Engineering

US GODAE: Global Ocean Prediction with the Hybrid Coordinate Ocean Model (HYCOM)

DTIC Science & Technology

2009-06-01

Administration, New York, NY, USA, and Earth Systems Research Laboratory, NOAA, Boulder, CO, USA. Remy Baraille is Research Scientist, Service Hydrographique...Coastal Sciences, Rutgers University, New Brunswick, NJ, USA. John Wilkin is Associate Professor, Institute of Marine and Coastal Sciences, Rutgers...University, New Brunswick, NJ, USA. Oceanography June 2009 67 coordinates (depth, density, and terrain- following) provide universal optimality, it is

78 FR 47817 - Parts and Accessories Necessary for Safe Operation; Application for an Exemption From Van Hool N...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

....V. and Coach USA AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of... exemption from Van Hool N.V. and Coach USA (Van Hool/Coach USA) to allow the use of double deck motorcoaches..., Van Hool/Coach USA is requesting an exemption that would allow the use of sleeper berths that comply...

Leading the way in biomedical engineering: an interview with Robert Langer. Interview by Hannah Stanwix, Commissioning Editor.

PubMed

Langer, Robert

2012-10-01

Professor Robert Langer obtained his Bachelor's Degree in Chemical Engineering from Cornell University (NY, USA) in 1970. He received his Sc.D. from the Massachusetts Institute of Technology (MA, USA) in 1974. He is currently the David H Koch Institute Professor at the Massachusetts Institute of Technology. Professor Langer is a member of the Institute of Medicine of the National Academy of Sciences, the National Academy of Engineering and the National Academy of Sciences. At the age of 43 he was the youngest person in history to be elected to all three United States National Academies. Throughout his career, Professor Langer has received over 200 awards including, notably, the Charles Stark Draper Prize (considered the equivalent of the Nobel Prize for engineers), the 2008 Millennium Prize, the 2006 United States National Medal of Science and the 2012 Priestley Medal. In 1996 he was awarded the Gairdner Foundation International Award (the only engineer ever to have been awarded this accolade). Professor Langer has also been the recipient of the Lemelson-MIT prize, which he was awarded with for being "one of history's most prolific inventors in medicine." Professor Langer was selected by Time Magazine in 2001 as one of the 100 most important people in the USA. He has received honorary degrees from several universities worldwide, including Harvard University (MA, USA), the Mt. Sinai School of Medicine (NY, USA), Yale University (CT, USA), the ETH Zurich (Zurich, Switzerland), the Technion-Israel Institute of Technology (Haifa, Israel), the Hebrew University of Jerusalem (Israel), the Université Catholique de Louvain (Louvain-La-Neuve, Belgium), Rensselaer Polytechnic Institute (NY, USA), Willamette University (OR, USA), the University of Liverpool (Liverpool, UK), Bates College (ME, USA), the University of Nottingham (Nottingham, UK), Albany Medical College (NY, USA), Pennsylvania State University (PA, USA), Northwestern University (IL, USA) and Uppsala University (Uppsala, Sweden), and was awarded with the University of California San Francisco Medal in 2009. Professor Langer has founded over 20 biotechnology companies and authored more than 1175 articles. He has over 800 issued or pending patents. Professor Langer is the most cited engineer in history.

Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional study.

PubMed

Joffres, Michel; Falaschetti, Emanuela; Gillespie, Cathleen; Robitaille, Cynthia; Loustalot, Fleetwood; Poulter, Neil; McAlister, Finlay A; Johansen, Helen; Baclic, Oliver; Campbell, Norm

2013-08-30

Comparison of recent national survey data on prevalence, awareness, treatment and control of hypertension in England, the USA and Canada, and correlation of these parameters with each country stroke and ischaemic heart disease (IHD) mortality. Non-institutionalised population surveys. England (2006 n=6873), the USA (2007-2010 n=10 003) and Canada (2007-2009 n=3485) aged 20-79 years. Stroke and IHD mortality rates were plotted against countries' specific prevalence data. Mean systolic blood pressure (SBP) was higher in England than in the USA and Canada in all age-gender groups. Mean diastolic blood pressure (DBP) was similar in the three countries before age 50 and then fell more rapidly in the USA, being the lowest in the USA. Only 34% had a BP under 140/90 mm Hg in England, compared with 50% in the USA and 66% in Canada. Prehypertension and stages 1 and 2 hypertension prevalence figures were the highest in England. Hypertension prevalence (≥140 mm Hg SBP and/or ≥90 mm Hg DBP) was lower in Canada (19·5%) than in the USA (29%) and England (30%). Hypertension awareness was higher in the USA (81%) and Canada (83%) than in England (65%). England also had lower levels of hypertension treatment (51%; USA 74%; Canada 80%) and control (<140/90 mm Hg; 27%; the USA 53%; Canada 66%). Canada had the lowest stroke and IHD mortality rates, England the highest and the rates were inversely related to the mean SBP in each country and strongly related to the blood pressure indicators, the strongest relationship being between low hypertension awareness and stroke mortality. While the current prevention efforts in England should result in future-improved figures, especially at younger ages, these data still show important gaps in the management of hypertension in these countries, with consequences on stroke and IHD mortality.

Testing of the International Space Station and X-38 Crew Return Vehicle GPS Receiver

NASA Technical Reports Server (NTRS)

Simpson, James; Campbell, Chip; Carpenter, Russell; Davis, Ed; Kizhner, Semion; Lightsey, E. Glenn; Davis, George; Jackson, Larry

1999-01-01

This paper discusses the process and results of the performance testing of the GPS receiver planned for use on the International Space Station (ISS) and the X-38 Crew Return Vehicle (CRV). The receiver is a Force-19 unit manufactured by Trimble Navigation and modified in software by the NASA Goddard Space Flight Center (GSFC) to perform navigation and attitude determination in space. The receiver is the primary source of navigation and attitude information for ISS and CRV. Engineers at GSFC have developed and tested the new receiver with a Global Simulation Systems Ltd (GSS) GPS Signal Generator (GPSSG). This paper documents the unique aspects of ground testing a GPS receiver that is designed for use in space. A discussion of the design of tests using the GPSSG, documentation, data capture, data analysis, and lessons learned will precede an overview of the performance of the new receiver. A description of the challenges that were overcome during this testing exercise will be presented. Results from testing show that the receiver will be within or near the specifications for ISS attitude and navigation performance. The process for verifying other requirements such as Time to First Fix, Time to First Attitude, selection/deselection of a specific GPS satellite vehicles (SV), minimum signal strength while still obtaining attitude and navigation, navigation and attitude output coverage, GPS week rollover, and Y2K requirements are also given in this paper.

Testing of the International Space Station and X-38 Crew Return Vehicle GPS Receiver

NASA Technical Reports Server (NTRS)

Simpson, James; Campbell, Chip; Carpenter, Russell; Davis, Ed; Kizhner, Semion; Lightsey, E. Glenn; Davis, George; Jackson, Larry

1999-01-01

This paper discusses the process and results of the performance testing of the GPS receiver planned for use on the International Space Station (ISS) and the X-38 Crew Return Vehicle (CRV). The receiver is a Force-19 unit manufactured by Trimble Navigation and Modified in software by the NASA Goddard Space Flight Center (GSFC) to perform navigation and attitude determination in space. The receiver is the primary source of navigation and attitude information for ISS and CRV. Engineers at GSFC have developed and tested the new receiver with a Global Simulation Systems Ltd (GSS) GPS Signal Generator (GPSSG). This paper documents the unique aspects of ground testing a GPS receiver that is designed for use in space. A discussion of the design and tests using the GPSSG, documentation, data capture, data analysis, and lessons learned will precede an overview of the performance of the new receiver. A description of the challenges of that were overcome during this testing exercise will be presented. Results from testing show that the receiver will be within or near the specifications for ISS attitude and navigation performance. The process for verifying other requirements such as Time to First Fix, Time to First Attitude, selection/deselection of a specific GPS satellite vehicles (SV), minimum signal strength while still obtaining attitude and navigation, navigation and attitude output coverage, GPS week rollover, and Y2K requirements are also given in this paper.

Sapc - Application for Adapting Scanned Analogue Photographs to Use Them in Structure from Motion Technology

NASA Astrophysics Data System (ADS)

Salach, A.

2017-05-01

The documentary value of analogue scanned photographs is invaluable. A large and rich collection of archival photographs is often the only source of information about past of the selected area. This paper presents a method of adaptation of scanned, analogue photographs to suitable form allowing to use them in Structure from Motion technology. For this purpose, an automatic algorithm, implemented in the application called SAPC (Scanned Aerial Photographs Correction), which transforms scans to a form, which characteristic similar to the images captured by a digital camera, was invented. Images, which are created in the applied program as output data, are characterized by the same principal point position in each photo and the same resolution through cutting out the black photo frame. Additionally, SAPC generates a binary image file, which can mask areas of fiducial marks. In the experimental section, scanned, analogue photographs of Warsaw, which had been captured in 1986, were used in two variants: unprocessed and processed in SAPC application. An insightful analysis was conducted on the influence of transformation in SAPC on quality of spatial orientation of photographs. Block adjustment through aerial triangulation was calculated using two SfM software products: Agisoft PhotoScan and Pix4d and their results were compared with results obtained from professional photogrammetric software - Trimble Inpho. The author concluded that pre-processing in SAPC application had a positive impact on a quality of block orientation of scanned, analogue photographs, using SfM technology.

Wetland Assessment Using Unmanned Aerial Vehicle (uav) Photogrammetry

NASA Astrophysics Data System (ADS)

Boon, M. A.; Greenfield, R.; Tesfamichael, S.

2016-06-01

The use of Unmanned Arial Vehicle (UAV) photogrammetry is a valuable tool to enhance our understanding of wetlands. Accurate planning derived from this technological advancement allows for more effective management and conservation of wetland areas. This paper presents results of a study that aimed at investigating the use of UAV photogrammetry as a tool to enhance the assessment of wetland ecosystems. The UAV images were collected during a single flight within 2½ hours over a 100 ha area at the Kameelzynkraal farm, Gauteng Province, South Africa. An AKS Y-6 MKII multi-rotor UAV and a digital camera on a motion compensated gimbal mount were utilised for the survey. Twenty ground control points (GCPs) were surveyed using a Trimble GPS to achieve geometrical precision and georeferencing accuracy. Structure-from-Motion (SfM) computer vision techniques were used to derive ultra-high resolution point clouds, orthophotos and 3D models from the multi-view photos. The geometric accuracy of the data based on the 20 GCP's were 0.018 m for the overall, 0.0025 m for the vertical root mean squared error (RMSE) and an over all root mean square reprojection error of 0.18 pixel. The UAV products were then edited and subsequently analysed, interpreted and key attributes extracted using a selection of tools/ software applications to enhance the wetland assessment. The results exceeded our expectations and provided a valuable and accurate enhancement to the wetland delineation, classification and health assessment which even with detailed field studies would have been difficult to achieve.

Hepatobiliary Hands of Hopkins.

PubMed

Pitt, Henry A

2018-02-01

This historical perspective documents the role that John L. Cameron played in advancing hepatobiliary research, education, and surgery at Johns Hopkins in the 1970s, 1980s, and 1990s. Dating back to William S. Halsted in the 19th century, leaders of the Department of Surgery at Johns Hopkins have been interested in hepatobiliary disease and surgery. John L. Cameron had broad hepato-pancreato-biliary (HPB) interests when he completed his surgical training. Over the next 3 decades, he focused on the pancreas. As a result, many faculty and trainee hepatobiliary careers were launched. This perspective is based on 18 years of service as a surgical resident and faculty member at Johns Hopkins. An extensive literature search on the hepatobiliary publications of Halsted, Trimble, Blalock, Longmire, Zuidema, and Cameron was undertaken for this manuscript. Numerous hepatobiliary publications from Johns Hopkins from the 1970s, 1980s, 1990s, and early 2000s were also reviewed. John L. Cameron's early biliary interests included stones, infections, malignancies, and strictures. He was innovative with respect to portal hypertension and Budd-Chiari surgery and supportive when liver transplantation emerged in the 1980s. Volume-outcome studies in the 1990s included hepatic and complex biliary surgery. He supported and encouraged studies of biliary lithotripsy, laparoscopic cholecystectomy, clinical pathways, hepatobiliary cysts, and gallstone pathogenesis. Lessons learned by many who worked with John L. Cameron included the importance of mentorship, innovation, friendship, and collaboration. He taught leadership and change management by example. He fostered a multidisciplinary approach and encouraged randomized controlled trials.

Testing of the International Space Station and X-38 Crew Return Vehicle GPS Receiver

NASA Technical Reports Server (NTRS)

Simpson, James; Lightsey, Glenn; Campbell, Chip; Carpenter, Russell; Davis, George; Jackson, Larry; Davis, Ed; Kizhner, Semion

1999-01-01

This paper discusses the process and results of the performance testing of the GPS receiver planned for use on the International Space Station (ISS) and the X- 38CrewReturnVehicle(CRV). The receiver is a Force-19 unit manufactured by Trimble Navigation and modified in software by NASA:s Goddard Space Flight Center (GSFC) to perform navigation and attitude determination in space. The receiver is the primary source of navigation and attitude information for ISS and CRV. Engineers at GSFC have developed and tested the new receiver with a Global Simulation Systems Ltd (GSS) GPS Signal Generator (GPSSG). This paper documents the unique aspects of ground testing a GPS receiver that is designed for use in space. A discussion of the design of tests using the GPSSG, documentation, data capture, data analysis, and lessons learned will precede an overview of the performance of the new receiver. A description of the challenges that were overcome during this testing exercise will be presented. Results from testing show that the receiver will be within or near the specifications for ISS attitude and navigation performance. The process for verifying other requirements such as Time to First Fix, Time to First Attitude, selection/deselection of a specific GPS satellite vehicles (SV), minimum signal strength while still obtaining attitude and navigation, navigation and attitude output coverage, GPS week rollover, and Y2K requirements are also given in this paper.

Evaluating variation in use of definitive therapy and risk-adjusted prostate cancer mortality in England and the USA.

PubMed

Sachdeva, Ashwin; van der Meulen, Jan H; Emberton, Mark; Cathcart, Paul J

2015-02-24

Prostate cancer mortality (PCM) in the USA is among the lowest in the world, whereas PCM in England is among the highest in Europe. This paper aims to assess the association of variation in use of definitive therapy on risk-adjusted PCM in England as compared with the USA. Observational study. Cancer registry data from England and the USA. Men diagnosed with non-metastatic prostate cancer (PCa) in England and the USA between 2004 and 2008. Competing-risks survival analyses to estimate subhazard ratios (SHR) of PCM adjusted for age, ethnicity, year of diagnosis, Gleason score (GS) and clinical tumour (cT) stage. 222,163 men were eligible for inclusion. Compared with American patients, English patients were more likely to present at an older age (70-79 years: England 44.2%, USA 29.3%, p<0.001), with higher tumour stage (cT3-T4: England 25.1%, USA 8.6%, p<0.001) and higher GS (GS 8-10: England 20.7%, USA 11.2%, p<0.001). They were also less likely to receive definitive therapy (England 38%, USA 77%, p<0.001). English patients were more likely to die of PCa (SHR=1.9, 95% CI 1.7 to 2.0, p<0.001). However, this difference was no longer statistically significant when also adjusted for use of definitive therapy (SHR=1.0, 95% CI 1.0 to 1.1, p=0.3). Risk-adjusted PCM is significantly higher in England compared with the USA. This difference may be explained by less frequent use of definitive therapy in England. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

75 FR 65317 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-22

..., 2010. Docket Numbers: ER11-85-000. Applicants: Societe Generale Energie (USA) Corp. Description: Societe Generale Energie (USA) Corp. submits tariff filing per 35.12: SGE USA Baseline Tariff Filing to be...

USA National Phenology Network gridded products documentation

USGS Publications Warehouse

Crimmins, Theresa M.; Marsh, R. Lee; Switzer, Jeff R.; Crimmins, Michael A.; Gerst, Katharine L.; Rosemartin, Alyssa H.; Weltzin, Jake F.

2017-02-23

The goals of the USA National Phenology Network (USA-NPN, www.usanpn.org) are to advance science, inform decisions, and communicate and connect with the public regarding phenology and species’ responses to environmental variation and climate change. The USA-NPN seeks to facilitate informed ecosystem stewardship and management by providing phenological information freely and openly. One way the USA-NPN is endeavoring to accomplish these goals is by providing data and data products in a wide range of formats, including gridded real-time, short-term forecasted, and historical maps of phenological events, patterns and trends. This document describes the suite of gridded phenologically relevant data products produced and provided by the USA National Phenology Network, which can be accessed at www.usanpn.org/data/phenology_maps and also through web services at geoserver.usanpn.org/geoserver/wms?request=GetCapabilities.

Predictive relationship of osteopathic manual medicine grades and COMLEX-USA Level 1 total scores and osteopathic principles and practice subscores.

PubMed

Lewis, Drew D; Johnson, Mary T; Finnerty, Edward P

2014-06-01

Osteopathic manual medicine (OMM) encompasses hands-on diagnosis and treatment as part of patient care. The area of osteopathic principles and practice (OPP) is considered a core competency for students and practitioners of this medical tradition. The Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) is a useful tool for assessing candidates' competency. To examine the relationship of COMLEX-USA Level 1 total scores and OPP subscores with OMM course grades, and to determine if these grades are predictive of COMLEX-USA Level 1 OPP performance. The authors collected data-COMLEX-USA Level 1 total and OPP subscores, OMM grades (written, practical, and total for first and second academic years), sex, and age-for a cohort of osteopathic medical students at a single institution, and these data were then analyzed by means of correlation analysis. Records were obtained from a second-year class of osteopathic medical students (N=217). The authors' analysis of total scores and OPP subscores on COMLEX-USA Level 1 yielded a statistically significant correlation with all variables. Although the correlations were moderate, second-year written examination grades showed the strongest association with the COMLEX-USA Level 1 OPP subscores (r=0.530) and total scores (r=0.566). Performance in the second-year OMM written examination could identify students potentially at risk for poor performance on COMLEX-USA Level 1. © 2014 The American Osteopathic Association.

76 FR 78910 - Decision and Order Granting a Waiver to LG Electronics U.S.A., Inc. From the Department of Energy...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-20

... and Order Granting a Waiver to LG Electronics U.S.A., Inc. From the Department of Energy Commercial.... Department of Energy's (DOE) Decision and Order in Case No. CAC-036, which grants LG Electronics U.S.A., Inc.... Decision and Order In the Matter of: LG Electronics U.S.A., Inc. (LG) (Case No. CAC- 036). Background Title...

75 FR 17947 - Endangered and Threatened Wildlife and Plants; 5-Year Status Reviews of 69 Species in Idaho...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

..., [Unnamed] Drosophila aglaia...... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila differens... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila hemipeza.... E U.S.A. (HI) 71 FR 26835; 5/9/2006. Pomace fly, [Unnamed] Drosophila heteroneura. E U.S.A. (HI) 71 FR 26835; 5/9...

Evidence for Type Ia Supernova Diversity from Ultraviolet Observations with the Hubble Space Telescope

DTIC Science & Technology

2012-04-20

Observational Cosmology , NASA Goddard Space Flight Center, Code 665, Greenbelt, MD 20771, USA 31 Enrico Fermi Institute, Department of Physics, and Kavli...Institute for Cosmological Physics, University of Chicago, Chicago, IL 60637, USA 32 Department of Physics and Astronomy, Rutgers, the State University...Austin, TX 78712, USA 59 Pittsburgh Particle Physics, Astrophysics, and Cosmology Center (Pitt-PACC), University of Pittsburgh, Pittsburgh, PA 15260, USA

Methods for Functional Connectivity Analyses

DTIC Science & Technology

2012-12-13

motor , or hand motor function (green, red, or blue shading, respectively). Thus, this work produced the first comprehensive analysis of ECoG...Computer Engineering, University of Texas at El Paso , TX, USA 3Department of Neurology, Albany Medical College, Albany, NY, USA 4Department of Computer...Department of Health, Albany, NY, USA bDepartment of Electrical and Computer Engineering, University of Texas at El Paso , TX, USA cDepartment of Neurology

PREFACE: XXXVI Symposium on Nuclear Physics (Cocoyoc 2013)

NASA Astrophysics Data System (ADS)

Barrón-Palos, Libertad; Morales-Agiss, Irving; Martínez-Quiroz, Enrique

2014-03-01

logo The XXXVI Symposium on Nuclear Physics, organized by the Division of Nuclear Physics of the Mexican Physical Society, took place from 7-10 January, 2013. As it is customary, the Symposium was held at the Hotel Hacienda Cocoyoc, in the state of Morelos, Mexico. Conference photograph This international venue with many years of tradition was attended by outstanding physicists, some of them already regulars to this meeting and others who joined us for the first time; a total of 45 attendees from different countries (Argentina, Brazil, Canada, China, Germany, Italy, Japan, Mexico and the United States). A variety of topics related to nuclear physics (nuclear reactions, radioactive beams, nuclear structure, fundamental neutron physics, sub-nuclear physics and nuclear astrophysics, among others) were presented in 26 invited talks and 10 contributed posters. Local Organizing Committee Libertad Barrón-Palos (IF-UNAM)) Enrique Martínez-Quíroz (ININ)) Irving Morales-Agiss (ICN-UNAM)) International Advisory Committee Osvaldo Civitarese (UNLP, Argentina) Jerry P Draayer (LSU, USA)) Alfredo Galindo-Uribarri (ORNL, USA)) Paulo Gomes (UFF, Brazil)) Piet Van Isacker (GANIL, France)) James J Kolata (UND, USA)) Reiner Krücken (TRIUMF, Canada)) Jorge López (UTEP, USA)) Stuart Pittel (UD, USA)) W Michael Snow (IU, USA)) Adam Szczepaniak (IU, USA)) Michael Wiescher (UND, USA)) A list of participants is available in the PDF

National assessment of Tree City USA participation

EPA Pesticide Factsheets

Tree City USA is a national program that recognizes municipal commitment to community forestry. In return for meeting program requirements, Tree City USA participants expect social, economic, and/or environmental benefits. Understanding the geographic distribution and socioeconomic characteristics of Tree City USA communities at the national scale can offer insights into the motivations or barriers to program participation, and provide context for community forestry research at finer scales. In this study, researchers assessed patterns in Tree City USA participation for all U.S. communities with more than 2,500 people according to geography, community population size, and socioeconomic characteristics, such as income, education, and race. Nationally, 23.5% of communities studied were Tree City USA participants, and this accounted for 53.9% of the total population in these communities. Tree City USA participation rates varied substantially by U.S. region, but in each region participation rates were higher in larger communities, and long-term participants tended to be larger communities than more recent enrollees. In logistic regression models, owner occupancy rates were significant negative predictors of Tree City USA participation, education and percent white population were positive predictors in many U.S. regions, and inconsistent patterns were observed for income and population age. The findings indicate that communities with smaller populations, lower educat

Precipitation Records-HDSC/OWP

Science.gov Websites

resources and services. Greatest observed point precipitation values for the world and the USA US Comparison of the greatest point precipitation values for the world and the USA. World records (map, table) USA

First Global Observations of the Interstellar Interaction from the Interstellar Boundary Explorer (Invited)

NASA Astrophysics Data System (ADS)

McComas, D. J.

2009-12-01

The Sun moves through the local interstellar medium, continuously emitting ionized, supersonic solar wind plasma and carving out a cavity in interstellar space, called the heliosphere. The Interstellar Boundary Explorer (IBEX) spacecraft has just completed the first all-sky maps of the interstellar interaction at the edge of the heliosphere, by imaging energetic neutral atoms (ENAs) emanating from this region. IBEX all-sky maps and energy spectra provide detailed information about the interaction. Our observations show globally distributed fluxes ordered by the solar wind structure, which are superposed by another, unexpected feature, which is neither seen by the Voyager spacecraft nor predicted by any current model or theory. This talk summarizes the IBEX observations, shares our unexpected results, and discusses some of the possible ideas for what may be missing in our current understanding of the heliosphere’s global interaction. IBEX Science Team: D.J. McComas1,2, F. Allegrini1,2, P. Bochsler3, M. Bzowski4, E.R. Christian5, G.B. Crew6, R. DeMajistre7, H. Fahr8, H. Fichtner9, P.C. Frisch10, H.O. Funsten11, S. A. Fuselier12, G. Gloeckler13, M. Gruntman14, J. Heerikhuisen15, V. Izmodenov16, P. Janzen17, P. Knappenberger18, S. Krimigis7,19, H. Kucharek20, M. Lee20, G. Livadiotis1, S. Livi1,2, R.J. MacDowall5, D. Mitchell7, E. Möbius20, T. Moore5, N.V. Pogorelov15, D. Reisenfeld17, E. Roelof7, L. Saul3, N.A. Schwadron21, P.W. Valek1,2, R. Vanderspek6, P. Wurz3, G.P. Zank15 (1)Southwest Research Institute, San Antonio, TX, USA (2) University of Texas at San Antonio, San Antonio, TX, USA (3)University of Bern, Physikalisches Institut, CH-3012 Bern, Switzerland (4)Space Research Centre of the Polish Academy of Sciences, Warsaw, Poland (5)NASA Goddard Space Flight Center, Greenbelt, MD, USA (6)Massachusetts Institute of Technology, Cambridge, MA, USA (7)Applied Physics Laboratory, Johns Hopkins University, Laurel, MD, USA (8)University of Bonn, Bonn, Germany (9)Ruhr-Universitaet Bochum, Bochum, Germany (10)University of Chicago, Chicago, IL, USA (11)Los Alamos National Laboratory, Los Alamos, NM, USA (12)Lockheed Martin Advanced Technology Center, Palo Alto, CA, USA (13)University of Michigan, Ann Arbor, MI, USA (14)University of Southern California, Los Angeles, CA, USA (15)University of Alabama, Huntsville, AL, USA (16) Moscow State University; Space Research Institute (IKI) and Institute for Problems in Mechanics Russian Academy of Sciences, Moscow, Russia (17)University of Montana, Missoula, MT, USA (18)Adler Planetarium, Chicago, IL, USA (19)Office for Space Research and Technology, Academy of Athens, Athens, Greece (20)University of New Hampshire, Space Science Center, Durham, NH, USA (21) Boston University, Boston, MA, USA

Defining Translational Reprogramming in Tuberous Sclerosis Complex

DTIC Science & Technology

2015-07-01

Genomics & Development, Cornell University, Ithaca, New York, USA. 3Department of Chemistry, The Scripps Research Inst tute, Jupiter , Florida, USA...4Molecular Therapeutics and Natural Products Library Initiative, The Scripps Research Institute, Jupiter , Florida, USA. 5Present address

American Military History and its Insights into Fourth Generation Warfare

DTIC Science & Technology

2006-01-01

8William S . Lind, Colonel Keith Nightengale (USA), Captain John F. Schmitt (USMC), Colonel Joseph W. Sutton (USA), and Lieutenant Colonel Gary I. Wilson...Lind, William S ., Colonel Keith Nightengale (USA), Captain John F. Schmitt (USMC), Colonel Joseph W. Sutton (USA), and Lieutenant Colonel Gary I...military history and its insights into fourth generation warfare. 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S

Treatment of Diabetic Ketoacidosis (DKA)/Hyperglycemic Hyperosmolar State (HHS): Novel Advances in the Management of Hyperglycemic Crises (UK Versus USA).

PubMed

Dhatariya, Ketan K; Vellanki, Priyathama

2017-05-01

Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are diabetic emergencies that cause high morbidity and mortality. Their treatment differs in the UK and USA. This review delineates the differences in diagnosis and treatment between the two countries. Large-scale studies to determine optimal management of DKA and HHS are lacking. The diagnosis of DKA is based on disease severity in the USA, which differs from the UK. The diagnosis of HHS in the USA is based on total rather than effective osmolality. Unlike the USA, the UK has separate guidelines for DKA and HHS. Treatment of DKA and HHS also differs with respect to timing of fluid and insulin initiation. There is considerable overlap but important differences between the UK and USA guidelines for the management of DKA and HHS. Further research needs to be done to delineate a unifying diagnostic and treatment protocol.

Increasing use of radical prostatectomy for locally advanced prostate cancer in the USA and Germany: a comparative population-based study.

PubMed

Hager, B; Kraywinkel, K; Keck, B; Katalinic, A; Meyer, M; Zeissig, S R; Scheufele, R; Wirth, M P; Huber, J

2017-03-01

Current guidelines do not recommend a preferred treatment modality for locally advanced prostate cancer. The aim of the study was to compare treatment patterns found in the USA and Germany and to analyze possible trends over time. We compared 'Surveillance Epidemiology and End Results' (SEER) data (USA) with reports from four German federal epidemiological cancer registries (Eastern Germany, Bavaria, Rhineland-Palatinate, Schleswig-Holstein), both from 2004 to 2012. We defined locally advanced prostate cancer as clinical stage T3 or T4. Exclusion criteria were metastatic disease and age over 79 years. We identified 9127 (USA) and 11 051 (Germany) patients with locally advanced prostate cancer. The share was 2.1% in the USA compared with 6.0% in Germany (P<0.001). In the United States, the utilization of radiotherapy (RT) and radical prostatectomy (RP) was comparably high with 42.0% (RT) and 42.8% (RP). In Germany, the major treatment option was RP with 36.7% followed by RT with 22.1%. During the study period, the use of RP increased in both countries (USA P=0.001 and Germany P=0.003), whereas RT numbers declined (USA P=0.003 and Germany P=0.002). The share of adjuvant RT (aRT) was similar in both countries (USA 21.7% vs Germany 20.7%). We found distinctive differences in treating locally advanced prostate cancer between USA and Germany, but similar trends over time. In the last decade, a growing number of patients underwent RP as a possible first step within a multimodal concept.

Differences in the utilization of gestational surrogacy between states in the U.S.

PubMed

Perkins, Kiran M; Boulet, Sheree L; Levine, Aaron D; Jamieson, Denise J; Kissin, Dmitry M

2018-04-01

Gestational surrogacy policy in the USA varies by state, but information on state differences is lacking. This study used data from the National Assisted Reproductive Technology Surveillance System from 2010 to 2014 to calculate state differences in gestational carrier cycle characteristics. Of the 662,165 in-vitro fertilization cycles in the USA between 2010 and 2014, 16,148 (2.4%) used gestational carriers. Non-USA residents accounted for 18.3% of gestational carrier cycles, and 29.1% of gestational carrier cycles by USA residents were performed in a state other than the state of residence of the intended parent. USA gestational surrogacy practice varies by state, potentially impacting patients' access to surrogacy services.

The Jewish contribution to medicine. Part III. The 19th and 20th centuries in the USA.

PubMed

Dubovsky, H

1989-08-05

The Jewish hospital movement in the USA, which started in the last century for Jews as foreign immigrants and was extended to the general population this century, is an extensive organisation. Refugee physicians from Europe laid the foundations of Jewish medical involvement in medicine in the USA with Abraham Jacobi, the founder of paediatrics, Landsteiner, who discovered blood grouping, and Waksman, who evolved streptomycin. Other eminent workers, such as the Flexner brothers in medical education and research, Libman, who pioneered blood culture in the USA, and Salk and Sabin with the poliomyelitis vaccine were prominent in the major contribution of Jews to medicine in the USA.

Final report on International Conference on Radiationless Transitions Held at Newport Beach, California on January 3-7, 1984.

DTIC Science & Technology

1984-12-31

Ca. 90007 USA Eric C. Apel Dr. G. Comtet Department of Chemstry Department of Chemistry University of CAlifornia University of Californiai Irvine...Chicago Tempo, Az 85827 USA Chicago, Ill. 60637 USA - Professor R. Kopelman Professor S’. H. Lin Department of Chemistry Department of Chemstry . University...Nadler Department of Chemstry Ms. B. Lawrence University of Southern Calif. Department of Chemistry Los Angeles, Ca. 90007 USA University of California

Sierra Army Depot, Phase 1, Remedial Investigation/Feasibility Study, Lassen County, California. Appendices G-Q

DTIC Science & Technology

1991-10-01

concentrations in the liquid phase. The role of the distribution coefficient in mitigating chemical migration is given in an approximation of nonuniform ...0.110 USA 60.0 12r- 990 1.11111 1219CN 0.230 USA 70.0 12-nor-199 Lull 12E1CM 0.240 UsA 80.0 12-spr-1990 LAIR 121PCN 0.260 USA 35.0 ?2-spr-I99 LOSl 121Cm

The Vietnam Cauldron: Defense Intelligence in the War for Southeast Asia

DTIC Science & Technology

2012-01-01

For the Patriots. Major Robert P. Perry, USA Celeste M. Brown Vivienne A. Clark Dorothy M. Curtiss Joan K. Pray Doris J. Watkins Colonel Charles R. Ray...USA Chief Warrant Officer Robert W. Prescott, USA Chief Warrant Officer Kenneth D. Welch, USA Petty Officer First Class Michael R. Wagner, USN...Marshall Karl W. Teepe Patricia E. Mickley Robert J. Hymel Rosa M. Chapa Sandra N. Foster Charles E. Sabin i Defense Intelligence Historical Perspectives

The Eighth Data Release Of The Sloan Digital Sky Survey: First Data From SDSS-3

DTIC Science & Technology

2011-04-01

Sunspot, NM 88349, USA 14 Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, NY 10003, USA 15 Department of...Park, PA 16802, USA 18 Institute of Cosmology and Gravitation (ICG), Dennis Sciama Building, Burnaby Road, University of Portsmouth, Portsmouth, PO1 3FX... Cosmology , Carnegie Mellon University, Pittsburgh, P.A. 15213, USA 26 Yale Center for Astronomy and Astrophysics, Yale University, New Haven, CT 06520

High youth access to movies that contain smoking in Europe compared with the USA.

PubMed

Hanewinkel, Reiner; Sargent, James D; Karlsdóttir, Sólveig; Jónsson, Stefán Hrafn; Mathis, Federica; Faggiano, Fabrizio; Poelen, Evelien A P; Scholte, Ron; Florek, Ewa; Sweeting, Helen; Hunt, Kate; Morgenstern, Matthis

2013-07-01

Based on evidence that exposure to smoking in movies is associated with adolescent smoking, the WHO has called on countries to assign a rating that restricts youth access to such movies. To evaluate youth access to movies that portray smoking in European countries and compare with that in the USA. The authors identified the most commercially successful movies screened in six European countries (Germany, Iceland, Italy, the Netherlands, Poland and UK) and the USA between 2004 and 2009. The authors coded the 464 movies that were screened in both Europe and the USA according to whether or not they portrayed smoking. 87% of the movies were 'youth' rated in Europe (ratings board classification as suitable for those younger than 16 years) compared to only 67% in the USA (suitable for those younger than 17 years). Smoking was portrayed in 319 (69%) movies. 85% of the movies that portrayed smoking were 'youth' rated in Europe compared with only 59% in the USA (p<0.001). Tobacco imagery is still common in popular films shown in European countries and the USA. None of the seven countries examined followed the WHO recommendations on restricting youth access to movies that portray smoking. Compared to the USA, European youths have access to substantially more movies in general, and this gives them access to more movies that portray smoking in particular.

Childbearing across borders: Fertility and parenthood attitudes and decisions among breast cancer survivors in USA and Portugal.

PubMed

Gonçalves, Vânia; Hudson, Janella; Canavarro, Maria Cristina; Morris, Julie; Lee, M Catherine; Donovan, Kristine A; Sutton, Steven K; Vadaparampil, Susan T; Quinn, Gwendolyn P

2018-04-16

To compare fertility and childbearing attitudes and decisions of Portuguese and American female reproductive aged breast cancer survivors. This was a cross-sectional study of 102 young breast cancer survivors (59 from Portugal and 43 from USA). Demographic, clinical and reproductive information were collected. Fertility and parenthood attitudes and decisions were assessed through a self-report questionnaire devised specifically for the study. Fertility issues became very important after the diagnosis for most of the women (51%). Few differences existed between USA and Portuguese participants. USA participants were more likely to undergo FP (23% USA vs Portugal 5%, p = 0.01). Portuguese women were more dissatisfied with their physician's explanations about fertility (Portugal: 23% vs USA: 3%; p = 0.01). Overall, women relied on their oncologist for fertility information (70%); only Portuguese women discussed fertility with their family medicine physician (11%). Overall, women showed positive attitudes towards motherhood. Portuguese women were more likely to report their partners placed more value on the family after their illness (Portuguese agree: 55% vs USA agree: 14%; p < 0.001). Fertility and childbearing after breast cancer are important issues regardless of culture, background or country's heath care system. Overall, few differences across the USA and Portuguese samples were found on fertility and childbearing attitudes and decisions. Copyright © 2018 Elsevier Ltd. All rights reserved.

OBIS-USA: a data-sharing legacy of the census of marine life

USGS Publications Warehouse

Sedberry, G.R.; Fautin, D.G.; Feldman, M.; Fornwall, M.D.; Goldstein, P.; Guralnick, R.P.

2011-01-01

The United States Geological Survey's Biological Informatics Program hosts OBIS-USA, the US node of the Ocean Biogeographic Information System (OBIS). OBIS-USA gathers, coordinates, applies standard formats to, and makeswidely available data on biological collections in marine waters of the United States and other areas where US investigators have collected data and, in some instances, specimens. OBIS-USA delivers its data to OBIS international, which then delivers its data to the Global Biodiversity Information Facility (GBIF) and other Web portals for marine biodiversity data. OBIS-USA currently has 145 data sets from 36 participants, representing over 6.5 million occurrence records of over 83,000 taxa from more than 888,000 locations. OBIS-USA, a legacy of the decade-long (2001-2010) international collaborative Census of Marine Life enterprise, continues to add data, including those from ongoing Census projects. Among the many challenges in creating OBIS, including OBIS-USA, were developing a community of trust and shared valueamong data providers, and demonstrating to providers the value of making their data accessible to others. Challenges also posed by the diversity of data sets relevant tomarine biodiversity stored on thousands of computers, in a variety of formats, not all widely accessible, have been met in OBIS-USA by implementing a uniform standard and publishing platform that is easily accessible to a broad range of users.

OBIS-USA: a data-sharing legacy of census of marine life

USGS Publications Warehouse

Sedberry, George R.; Fautin, Daphne G.; Feldman, Michael; Fornwall, Mark D.; Goldstein, Phillip; Guralnick, Robert P.

2011-01-01

The United States Geological Survey's Biological Informatics Program hosts OBIS-USA, the US node of the Ocean Biogeographic Information System (OBIS). OBIS-USA gathers, coordinates, applies standard formats to, and makes widely available data on biological collections in marine waters of the United States and other areas where US investigators have collected data and, in some instances, specimens. OBIS-USA delivers its data to OBIS international, which then delivers its data to the Global Biodiversity Information Facility (GBIF) and other Web portals for marine biodiversity data. OBIS-USA currently has 145 data sets from 36 participants, representing over 6.5 million occurrence records of over 83,000 taxa from more than 888,000 locations. OBIS-USA, a legacy of the decade-long (2001–2010) international collaborative Census of Marine Life enterprise, continues to add data, including those from ongoing Census projects. Among the many challenges in creating OBIS, including OBIS-USA, were developing a community of trust and shared value among data providers, and demonstrating to providers the value of making their data accessible to others. Challenges also posed by the diversity of data sets relevant to marine biodiversity stored on thousands of computers, in a variety of formats, not all widely accessible, have been met in OBIS-USA by implementing a uniform standard and publishing platform that is easily accessible to a broad range of users.

Multifactorial Likelihood Assessment of BRCA1 and BRCA2 Missense Variants Confirms That BRCA1:c.122A>G(p.His41Arg) Is a Pathogenic Mutation

PubMed Central

Whiley, Phillip J.; Parsons, Michael T.; Leary, Jennifer; Tucker, Kathy; Warwick, Linda; Dopita, Belinda; Thorne, Heather; Lakhani, Sunil R.; Goldgar, David E.; Brown, Melissa A.; Spurdle, Amanda B.

2014-01-01

Rare exonic, non-truncating variants in known cancer susceptibility genes such as BRCA1 and BRCA2 are problematic for genetic counseling and clinical management of relevant families. This study used multifactorial likelihood analysis and/or bioinformatically-directed mRNA assays to assess pathogenicity of 19 BRCA1 or BRCA2 variants identified following patient referral to clinical genetic services. Two variants were considered to be pathogenic (Class 5). BRCA1:c.4484G> C(p.Arg1495Thr) was shown to result in aberrant mRNA transcripts predicted to encode truncated proteins. The BRCA1:c.122A>G(p.His41Arg) RING-domain variant was found from multifactorial likelihood analysis to have a posterior probability of pathogenicity of 0.995, a result consistent with existing protein functional assay data indicating lost BARD1 binding and ubiquitin ligase activity. Of the remaining variants, seven were determined to be not clinically significant (Class 1), nine were likely not pathogenic (Class 2), and one was uncertain (Class 3).These results have implications for genetic counseling and medical management of families carrying these specific variants. They also provide additional multifactorial likelihood variant classifications as reference to evaluate the sensitivity and specificity of bioinformatic prediction tools and/or functional assay data in future studies. PMID:24489791

Evidence-Based Evaluation of Inferior Vena Cava Filter Complications Based on Filter Type

PubMed Central

Deso, Steven E.; Idakoji, Ibrahim A.; Kuo, William T.

2016-01-01

Many inferior vena cava (IVC) filter types, along with their specific risks and complications, are not recognized. The purpose of this study was to evaluate the various FDA-approved IVC filter types to determine device-specific risks, as a way to help identify patients who may benefit from ongoing follow-up versus prompt filter retrieval. An evidence-based electronic search (FDA Premarket Notification, MEDLINE, FDA MAUDE) was performed to identify all IVC filter types and device-specific complications from 1980 to 2014. Twenty-three IVC filter types (14 retrievable, 9 permanent) were identified. The devices were categorized as follows: conical (n = 14), conical with umbrella (n = 1), conical with cylindrical element (n = 2), biconical with cylindrical element (n = 2), helical (n = 1), spiral (n = 1), and complex (n = 1). Purely conical filters were associated with the highest reported risks of penetration (90–100%). Filters with cylindrical or umbrella elements were associated with the highest reported risk of IVC thrombosis (30–50%). Conical Bard filters were associated with the highest reported risks of fracture (40%). The various FDA-approved IVC filter types were evaluated for device-specific complications based on best current evidence. This information can be used to guide and optimize clinical management in patients with indwelling IVC filters. PMID:27247477

Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance

PubMed Central

Stål, Per

2015-01-01

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world, with a prevalence of 20%. In a subgroup of patients, inflammation, ballooning degeneration of hepatocytes and a varying degree of fibrosis may develop, a condition named non-alcoholic steatohepatitis. Advanced liver fibrosis (stage F3) and cirrhosis (stage F4) are histologic features that most accurately predict increased mortality in both liver-related and cardiovascular diseases. Patients with advanced fibrosis or cirrhosis are at risk for complications such as hepatocellular carcinoma and esophageal varices and should therefore be included in surveillance programs. However, liver disease and fibrosis are often unrecognized in patients with NAFLD, possibly leading to a delayed diagnosis of complications. The early diagnosis of advanced fibrosis in NAFLD is therefore crucial, and it can be accomplished using serum biomarkers (e.g., the NAFLD Fibrosis Score, Fib-4 Index or BARD) or non-invasive imaging techniques (transient elastography or acoustic radiation force impulse imaging). The screening of risk groups, such as patients with obesity and/or type 2 diabetes mellitus, for NAFLD development with these non-invasive methods may detect advanced fibrosis at an early stage. Additionally, patients with a low risk for advanced fibrosis can be identified, and the need for liver biopsies can be minimized. This review focuses on the diagnostic challenge and prognostic impact of advanced liver fibrosis in NAFLD. PMID:26494963

Non-invasive Diagnosis of Fibrosis in Non-alcoholic Fatty Liver Disease

PubMed Central

Arora, Anil; Sharma, Praveen

2012-01-01

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed as well as in developing countries. Its prevalence continues to rise currently affecting approximately 20-30% of adults and 10% of children in the United States. Non-alcoholic fatty liver disease represents a wide spectrum of conditions ranging from fatty liver, which in general follows a benign non-progressive clinical course, to non-alcoholic steatohepatitis (NASH), a more serious form of NAFLD that may progress to cirrhosis and end-stage liver disease. Liver biopsy remains the gold standard for evaluating the degree of hepatic necroinflammation and fibrosis; however, several non-invasive investigations, such as serum biomarkers, have been developed to establish the diagnosis and also to evaluate treatment response. There has been a substantial development of non-invasive risk scores, biomarker panels, and radiological modalities to identify at risk patients with NAFLD without recourse to liver biopsy on a routine basis. Examples include combination of serum markers like NAFLD fibrosis score (NFS), BARD score, fibrometer, FIB4, and non-invasive tools like fibroscan which assess fibrosis in patients with NAFLD. Other markers of fibrosis that have been evaluated include high-sensitivity C-reactive protein, plasma pentraxin 3, interleukin-6, and cytokeratin-18. This review focuses on the methods currently available in daily clinical practice in hepatology and touches briefly on the potential future markers under investigation. PMID:25755423

Liver fibrosis in non-alcoholic fatty liver disease - diagnostic challenge with prognostic significance.

PubMed

Stål, Per

2015-10-21

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world, with a prevalence of 20%. In a subgroup of patients, inflammation, ballooning degeneration of hepatocytes and a varying degree of fibrosis may develop, a condition named non-alcoholic steatohepatitis. Advanced liver fibrosis (stage F3) and cirrhosis (stage F4) are histologic features that most accurately predict increased mortality in both liver-related and cardiovascular diseases. Patients with advanced fibrosis or cirrhosis are at risk for complications such as hepatocellular carcinoma and esophageal varices and should therefore be included in surveillance programs. However, liver disease and fibrosis are often unrecognized in patients with NAFLD, possibly leading to a delayed diagnosis of complications. The early diagnosis of advanced fibrosis in NAFLD is therefore crucial, and it can be accomplished using serum biomarkers (e.g., the NAFLD Fibrosis Score, Fib-4 Index or BARD) or non-invasive imaging techniques (transient elastography or acoustic radiation force impulse imaging). The screening of risk groups, such as patients with obesity and/or type 2 diabetes mellitus, for NAFLD development with these non-invasive methods may detect advanced fibrosis at an early stage. Additionally, patients with a low risk for advanced fibrosis can be identified, and the need for liver biopsies can be minimized. This review focuses on the diagnostic challenge and prognostic impact of advanced liver fibrosis in NAFLD.

Long non-coding RNAs as novel expression signatures modulate DNA damage and repair in cadmium toxicology

NASA Astrophysics Data System (ADS)

Zhou, Zhiheng; Liu, Haibai; Wang, Caixia; Lu, Qian; Huang, Qinhai; Zheng, Chanjiao; Lei, Yixiong

2015-10-01

Increasing evidence suggests that long non-coding RNAs (lncRNAs) are involved in a variety of physiological and pathophysiological processes. Our study was to investigate whether lncRNAs as novel expression signatures are able to modulate DNA damage and repair in cadmium(Cd) toxicity. There were aberrant expression profiles of lncRNAs in 35th Cd-induced cells as compared to untreated 16HBE cells. siRNA-mediated knockdown of ENST00000414355 inhibited the growth of DNA-damaged cells and decreased the expressions of DNA-damage related genes (ATM, ATR and ATRIP), while increased the expressions of DNA-repair related genes (DDB1, DDB2, OGG1, ERCC1, MSH2, RAD50, XRCC1 and BARD1). Cadmium increased ENST00000414355 expression in the lung of Cd-exposed rats in a dose-dependent manner. A significant positive correlation was observed between blood ENST00000414355 expression and urinary/blood Cd concentrations, and there were significant correlations of lncRNA-ENST00000414355 expression with the expressions of target genes in the lung of Cd-exposed rats and the blood of Cd exposed workers. These results indicate that some lncRNAs are aberrantly expressed in Cd-treated 16HBE cells. lncRNA-ENST00000414355 may serve as a signature for DNA damage and repair related to the epigenetic mechanisms underlying the cadmium toxicity and become a novel biomarker of cadmium toxicity.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, Yueying; Kruger, Albert A.

The Hanford Tank Waste Treatment and Immobilization Plant (WTP) Statement of Work (Department of Energy Contract DE-AC27-01RV14136, Section C) requires the contractor to develop and use process models for flowsheet analyses and pre-operational planning assessments. The Dynamic (G2) Flowsheet is a discrete-time process model that enables the project to evaluate impacts to throughput from eventdriven activities such as pumping, sampling, storage, recycle, separation, and chemical reactions. The model is developed by the Process Engineering (PE) department, and is based on the Flowsheet Bases, Assumptions, and Requirements Document (24590-WTP-RPT-PT-02-005), commonly called the BARD. The terminologies of Dynamic (G2) Flowsheet and Dynamicmore » (G2) Model are interchangeable in this document. The foundation of this model is a dynamic material balance governed by prescribed initial conditions, boundary conditions, and operating logic. The dynamic material balance is achieved by tracking the storage and material flows within the plant as time increments. The initial conditions include a feed vector that represents the waste compositions and delivery sequence of the Tank Farm batches, and volumes and concentrations of solutions in process equipment before startup. The boundary conditions are the physical limits of the flowsheet design, such as piping, volumes, flowrates, operation efficiencies, and physical and chemical environments that impact separations, phase equilibriums, and reaction extents. The operating logic represents the rules and strategies of running the plant.« less

Measurement of elliptic flow of light nuclei at s N N = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at the BNL Relativistic Heavy Ion Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.

Here we present measurements of second-order azimuthal anisotropy ( v 2 ) at midrapidity ( |y| < 1.0 ) for light nuclei d , t , 3He (formore » $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and antinuclei$$\\bar{d}$$ ( $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, and 19.6 GeV) and 3 ¯¯¯¯¯ He ( $$\\sqrt{s}$$$_{NN}$$ = 200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The v 2 for these light nuclei produced in heavy-ion collisions is compared with those for p and $$\\bar{p}$$. We observe mass ordering in nuclei v 2 ( p T) at low transverse momenta ( p T < 2.0 GeV/c). We also find a centrality dependence of v 2 for d and $$\\bar{d}$$ . The magnitude of v 2 for t and 3He agree within statistical errors. Light-nuclei v 2 are compared with predictions from a blast-wave model. Atomic mass number ( A ) scaling of light-nuclei v 2 (p T) seems to hold for p T / A < 1.5 GeV/c . Results on light-nuclei v 2 from a transport-plus-coalescence model are consistent with the experimental measurements.« less

Measurement of elliptic flow of light nuclei at s N N = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at the BNL Relativistic Heavy Ion Collider

DOE PAGES

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; ...

2016-09-23

Here we present measurements of second-order azimuthal anisotropy ( v 2 ) at midrapidity ( |y| < 1.0 ) for light nuclei d , t , 3He (formore » $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and antinuclei$$\\bar{d}$$ ( $$\\sqrt{s}$$$_{NN}$$ = 200 , 62.4, 39, 27, and 19.6 GeV) and 3 ¯¯¯¯¯ He ( $$\\sqrt{s}$$$_{NN}$$ = 200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The v 2 for these light nuclei produced in heavy-ion collisions is compared with those for p and $$\\bar{p}$$. We observe mass ordering in nuclei v 2 ( p T) at low transverse momenta ( p T < 2.0 GeV/c). We also find a centrality dependence of v 2 for d and $$\\bar{d}$$ . The magnitude of v 2 for t and 3He agree within statistical errors. Light-nuclei v 2 are compared with predictions from a blast-wave model. Atomic mass number ( A ) scaling of light-nuclei v 2 (p T) seems to hold for p T / A < 1.5 GeV/c . Results on light-nuclei v 2 from a transport-plus-coalescence model are consistent with the experimental measurements.« less

Bridging Plant and Human Radiation Response and DNA Repair through an In Silico Approach

PubMed Central

Nikitaki, Zacharenia; Pavlopoulou, Athanasia; Holá, Marcela; Donà, Mattia; Michalopoulos, Ioannis; Balestrazzi, Alma; Angelis, Karel J.; Georgakilas, Alexandros G.

2017-01-01

The mechanisms of response to radiation exposure are conserved in plants and animals. The DNA damage response (DDR) pathways are the predominant molecular pathways activated upon exposure to radiation, both in plants and animals. The conserved features of DDR in plants and animals might facilitate interdisciplinary studies that cross traditional boundaries between animal and plant biology in order to expand the collection of biomarkers currently used for radiation exposure monitoring (REM) in environmental and biomedical settings. Genes implicated in trans-kingdom conserved DDR networks often triggered by ionizing radiation (IR) and UV light are deposited into biological databases. In this study, we have applied an innovative approach utilizing data pertinent to plant and human genes from publicly available databases towards the design of a ‘plant radiation biodosimeter’, that is, a plant and DDR gene-based platform that could serve as a REM reliable biomarker for assessing environmental radiation exposure and associated risk. From our analysis, in addition to REM biomarkers, a significant number of genes, both in human and Arabidopsis thaliana, not yet characterized as DDR, are suggested as possible DNA repair players. Last but not least, we provide an example on the applicability of an Arabidopsis thaliana—based plant system monitoring the role of cancer-related DNA repair genes BRCA1, BARD1 and PARP1 in processing DNA lesions. PMID:28587301

Bridging Plant and Human Radiation Response and DNA Repair through an In Silico Approach.

PubMed

Nikitaki, Zacharenia; Pavlopoulou, Athanasia; Holá, Marcela; Donà, Mattia; Michalopoulos, Ioannis; Balestrazzi, Alma; Angelis, Karel J; Georgakilas, Alexandros G

2017-06-06

The mechanisms of response to radiation exposure are conserved in plants and animals. The DNA damage response (DDR) pathways are the predominant molecular pathways activated upon exposure to radiation, both in plants and animals. The conserved features of DDR in plants and animals might facilitate interdisciplinary studies that cross traditional boundaries between animal and plant biology in order to expand the collection of biomarkers currently used for radiation exposure monitoring (REM) in environmental and biomedical settings. Genes implicated in trans-kingdom conserved DDR networks often triggered by ionizing radiation (IR) and UV light are deposited into biological databases. In this study, we have applied an innovative approach utilizing data pertinent to plant and human genes from publicly available databases towards the design of a 'plant radiation biodosimeter', that is, a plant and DDR gene-based platform that could serve as a REM reliable biomarker for assessing environmental radiation exposure and associated risk. From our analysis, in addition to REM biomarkers, a significant number of genes, both in human and Arabidopsis thaliana, not yet characterized as DDR, are suggested as possible DNA repair players. Last but not least, we provide an example on the applicability of an Arabidopsis thaliana- based plant system monitoring the role of cancer-related DNA repair genes BRCA1 , BARD1 and PARP1 in processing DNA lesions.

Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms

PubMed Central

Tenedini, E; Bernardis, I; Artusi, V; Artuso, L; Roncaglia, E; Guglielmelli, P; Pieri, L; Bogani, C; Biamonte, F; Rotunno, G; Mannarelli, C; Bianchi, E; Pancrazzi, A; Fanelli, T; Malagoli Tagliazucchi, G; Ferrari, S; Manfredini, R; Vannucchi, A M; Tagliafico, E

2014-01-01

With the intent of dissecting the molecular complexity of Philadelphia-negative myeloproliferative neoplasms (MPN), we designed a target enrichment panel to explore, using next-generation sequencing (NGS), the mutational status of an extensive list of 2000 cancer-associated genes and microRNAs. The genomic DNA of granulocytes and in vitro-expanded CD3+T-lymphocytes, as a germline control, was target-enriched and sequenced in a learning cohort of 20 MPN patients using Roche 454 technology. We identified 141 genuine somatic mutations, most of which were not previously described. To test the frequency of the identified variants, a larger validation cohort of 189 MPN patients was additionally screened for these mutations using Ion Torrent AmpliSeq NGS. Excluding the genes already described in MPN, for 8 genes (SCRIB, MIR662, BARD1, TCF12, FAT4, DAP3, POLG and NRAS), we demonstrated a mutation frequency between 3 and 8%. We also found that mutations at codon 12 of NRAS (NRASG12V and NRASG12D) were significantly associated, for primary myelofibrosis (PMF), with highest dynamic international prognostic scoring system (DIPSS)-plus score categories. This association was then confirmed in 66 additional PMF patients composing a final dataset of 168 PMF showing a NRAS mutation frequency of 4.7%, which was associated with a worse outcome, as defined by the DIPSS plus score. PMID:24150215

Extended transurethral resection and Nd:YAG laser ablation of the prostate (TURLAP) for carcinoma: a pilot study

NASA Astrophysics Data System (ADS)

Childs, Stacy J.

1993-05-01

Transurethral resection of the prostate (TURP) has been combined with Nd:YAG application for the treatment of prostatic carcinoma for a decade. The inability to deliver the energy at right angles has made the procedure technically difficult, but results have been encouraging. A pilot study was begun in 1991 on ten patients who refused or were not candidates for radical prostatectomy. The protocol consisted of transrectal ultrasound imaging (TRUS) during extended TURP (EXTURP) followed immediately by Nd:YAG energy applied to the prostate bed and capsule. A second laser application under real time TRUS followed in eight weeks and a third (or fourth in one patient) was undertaken eight weeks later. Energy of 30,000- 85,000 Joules was applied during each procedure with the right angle urolase fiber (Bard) at 60 watts. Lesions were created for 30-60 seconds in each area of remaining tissue documented on TRUS. A thermocoupler was used to monitor rectal temperature. Complications include urinary retention, gross hematuria, bladder neck contracture, early incontinence, late incontinence, and probable permanent incontinence. Of the only four potent patients preoperatively, all (100%) are impotent now. TURLAP appears to be a safe and effective method of killing prostate malignant tissue and should be further studied perhaps in combination with interstitial laser irradiation to increase efficacy and lessen complications.

National Assessment of Tree City USA Participation According to Geography and Socioeconomic Characteristics

EPA Science Inventory

Tree City USA is a national program that recognizes municipal commitment to community forestry. In return for meeting program requirements, Tree City USA participants expect social, economic, and/or environmental benefits. Understandingthe geographic distribution and socioeconomi...

Assessment of clinical pathology and pathogen exposure in sea otters (Enhydra lutris) bordering the threatened population in Alaska

USGS Publications Warehouse

Goldstein, Tracey; Gill, Verena A.; Tuomi, Pamela A.; Monson, Daniel H.; Burdin, Alexander; Conrad, Patricia A.; Dunn, J. Lawrence; Field, Cara L.; Johnson, Christine K.; Jessup, David A.; Bodkin, James L.; Doroff, Angela M.

2011-01-01

Northern sea otter (Enhydra lutris kenyoni) abundance has decreased dramatically over portions of southwest Alaska, USA, since the mid-1980s, and this stock is currently listed as threatened under the Endangered Species Act. In contrast, adjacent populations in south central Alaska, USA, and Russia have been stable to increasing during the same period. Sea otters bordering the area classified in the recent decline were live-captured during 2004–2006 at Bering Island, Russia, and the Kodiak Archipelago, Alaska, USA, to evaluate differences in general health and current exposure status to marine and terrestrial pathogens. Although body condition was lower in animals captured at Bering Island, Russia, than it was at Kodiak, USA, clinical pathology values did not reveal differences in general health between the two regions. Low prevalences of antibodies (>5%) were found in Kodiak, USA, and on Bering Island, Russia, to Toxoplasma gondii, Sarcocystis neurona, and Leptospira interrogans. Exposure to phocine herpesvirus-1 was found in both Kodiak, USA (15.2%), and Bering Island, Russia (2.3%). Antibodies to Brucella spp. were found in 28% of the otters tested on Bering Island, Russia, compared with only 2.7% of the samples from Kodiak, USA. Prevalence of exposure to Phocine distemper virus (PDV) was 41% in Kodiak, USA, but 0% on Bering Island, Russia. Archived sera from southwest and south-central Alaska dating back to 1989 were negative for PDV, indicating exposure occurred in sea otters in Kodiak, USA, in recent years. Because PDV can be highly pathogenic in naïve and susceptible marine mammal populations, tissues should be examined to explore the contribution of this virus to otter deaths. Our results reveal an increase in exposure to pathogens in sea otters in Kodiak, Alaska, USA, since the 1990s.

Can genomics clarify the origins of Boreioglycaspis melaleucae in California, USA?

USDA-ARS?s Scientific Manuscript database

The Australian psyllid Boreioglycaspis melaleucae is a biological control agent of Melaleuca quinquenervia in Florida (USA) but was observed attacking M. quinquenervia trees in southern California (USA). Genotyping revealed the California population matched three of eight Australian haplotypes and ...

Public Notice: Proposed Land Ban Exemption to Ineos USA LLC

EPA Pesticide Factsheets

Public notice for proposed Land Ban Exemption Reissuance, for Ineos USA LLC, to continue to inject hazardous waste deep underground in Allen County, OH. EPA plans to reissue a Land Ban Exemption for Ineos USA LLC in Allen Co., OH.

USA Science and Engineering Festival 2014

NASA Image and Video Library

2014-04-25

Attendees of the USA Science and Engineering Festival explore all of the exhibits at the NASA Stage. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

Defense Science Board Force Protection Panel Report to DSB

DTIC Science & Technology

1997-12-01

John Cowan, Jr., USMC USMC-MCCDC COL Dan Hahn, USA J-34 COL Hal Johnson, USA J-34 OPS Mr. Paul Kozemchak DARPA/ISO Mr. Roberto Mata ATSD(NCB)/CP CAPT...Ame Nelson, USN OPNAV N312 COL Robert Neubert , USA Army DCSOPS LtCol Roby, USAF AF/XOIIA Mr. John J. Sloan Defense Intelligence Agency Mr. Dan Spohn...Ame Nelson, USN 33. US Army Force Protection Budget: COL Robert Neubert , USA 34. US Marine Corps Force Protection Budget: LtCol Street, USMC 35. CBT

Complete genome sequence of community-associated methicillin-resistant Staphylococcus aureus (strain USA400-0051), a prototype of the USA400 clone

PubMed Central

Côrtes, Marina Farrel; Costa, Maiana OC; Lima, Nicholas CB; Souza, Rangel C; Almeida, Luiz GP; Guedes, Luciane Prioli Ciapina; Vasconcelos, Ana TR; Nicolás, Marisa F; Figueiredo, Agnes MS

2017-01-01

Staphylococcus aureus subsp. aureus, commonly referred as S. aureus, is an important bacterial pathogen frequently involved in hospital- and community-acquired infections in humans, ranging from skin infections to more severe diseases such as pneumonia, bacteraemia, endocarditis, osteomyelitis, and disseminated infections. Here, we report the complete closed genome sequence of a community-acquired methicillin-resistant S. aureus strain, USA400-0051, which is a prototype of the USA400 clone. PMID:29091141

System Hazard Analysis of TACOM’s Crew Station/Turret Motion Base Simulator

DTIC Science & Technology

1992-01-01

Safety devices have been located on the equipment where necessary and are described in the Contraves USA Manual No. IM-27751, "INSTRUCTION MANUAL FOR...OF TACOM’s CREW STATION/TURRET MOTION BASE SIMULATOR" and Contraves USA Manual No. IM-27751, "INSTRUCTION MANUAL FOR TACOM" in an attempt to satisfy... Contraves USA and assembled jointly by Contraves USA and TACOM. All control compensation was performed by TACOM. The CS/TMBS is expected to open doors

Contaminant Concentrations in Storm Water Entering the Sinclair/Dyes Inlet Subasin of the Puget Sound, USA During Storm Event and Baseflow Conditions

DTIC Science & Technology

2007-03-01

Contaminant Concentrations in Storm Water Entering the Sinclair/Dyes Inlet Subasin of the Puget Sound , USA During Storm Event and Baseflow Conditions...Johnston1 (Space and Naval Warfare Systems Center, Bremerton, WA, USA), Dwight E. Leisle, Bruce Beckwith, and Gerald Sherrell ( Puget Sound Naval Shipyard...The Sinclair and Dyes Inlet watershed is located on the west side of Puget Sound in Kitsap County, Washington, U.S.A. (Figure 1). Puget Sound Naval

An observational study of the timing of surgery, use of laparoscopy and outcomes for acute cholecystitis in the USA and UK.

PubMed

Murray, A C; Markar, S; Mackenzie, H; Baser, O; Wiggins, T; Askari, A; Hanna, G; Faiz, O; Mayer, E; Bicknell, C; Darzi, A; Kiran, R P

2018-01-08

Evidence supports early laparoscopic cholecystectomy for acute cholecystitis. Differences in treatment patterns between the USA and UK, associated outcomes and resource utilization are not well understood. In this retrospective, observational study using national administrative data, emergency patients admitted with acute cholecystitis were identified in England (Hospital Episode Statistics 1998-2012) and USA (National Inpatient Sample 1998-2011). Proportions of patients who underwent emergency cholecystectomy, utilization of laparoscopy and associated outcomes including length of stay (LOS) and complications were compared. The effect of delayed treatment on subsequent readmissions was evaluated for England. Patients with a diagnosis of acute cholecystitis totaled 1,191,331 in the USA vs. 288 907 in England. Emergency cholecystectomy was performed in 628,395 (52.7% USA) and 45,299 (15.7% England) over the time period. Laparoscopy was more common in the USA (82.8 vs. 37.9%; p < 0.001). Pre-treatment (1 vs. 2 days; p < 0.001) and total ( 4 vs. 7 days; p < 0.001) LOS was lower in the USA. Overall incidence of bile duct injury was higher in England than the USA (0.83 vs. 0.43%; p < 0.001), but was no different following laparoscopic surgery (0.1%). In England, 40.5% of patients without an immediate cholecystectomy were subsequently readmitted with cholecystitis. An additional 14.5% were admitted for other biliary complications, amounting to 2.7 readmissions per patient in the year following primary admission. This study highlights management practices for acute cholecystitis in the USA and England. Despite best evidence, index admission laparoscopic cholecystectomy is performed less in England, which significantly impacts subsequent healthcare utilization.

Comittees

NASA Astrophysics Data System (ADS)

2004-10-01

Fritz Caspers (CERN, Switzerland), Michel Chanel (CERN, Switzerland), Håkan Danared (MSL, Sweden), Bernhard Franzke (GSI, Germany), Manfred Grieser (MPI für Kernphysik, Germany), Dieter Habs (LMU München, Germany), Jeffrey Hangst (University of Aarhus, Denmark), Takeshi Katayama (RIKEN/Univ. Tokyo, Japan), H.-Jürgen Kluge (GSI, Germany), Shyh-Yuan Lee (Indiana University, USA), Rudolf Maier (FZ Jülich, Germany), John Marriner (FNAL, USA), Igor Meshkov (JINR, Russia), Dieter Möhl (CERN, Switzerland), Vasily Parkhomchuk (BINP, Russia), Robert Pollock (Indiana University), Dieter Prasuhn (FZ Jülich, Germany), Dag Reistad (TSL, Sweden), John Schiffer (ANL, USA), Andrew Sessler (LBNL, USA), Alexander Skrinsky (BINP, Russia), Markus Steck (GSI, Germany), Jie Wei (BNL, USA), Andreas Wolf (MPI für Kernphysik, Germany), Hongwei Zhao (IMP, People's Rep. of China).

76 FR 3621 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

.... Eastern Time on Monday, January 31, 2011. Docket Numbers: ER11-2166-001. Applicants: Planet Energy (USA) Corp. Description: Planet Energy (USA) Corp. submits tariff filing per 35.17(b): Planet Energy USA.... Applicants: Planet Energy (Pennsylvania) Corp. Description: Planet Energy (Pennsylvania) Corp. submits tariff...

Perceived discrimination among three groups of refugees resettled in the USA: associations with language, time in the USA, and continent of origin.

PubMed

Hadley, Craig; Patil, Crystal

2009-12-01

The objectives of this study were to assess the prevalence and predictors of discrimination among a community-based sample of refugees resettled in the USA. We sought to test whether language, gender, time in the USA and country of origin were associated with the experience of discrimination among individuals resettled in the USA as part of the refugee resettlement program. Perceived discrimination was assessed among individuals from East Africa (n = 92), West Africa (n = 74), and from Eastern Europe (n = 112) using a multi-item measure of discrimination. Bivariate associations revealed statistically significant associations between experiences of discrimination and time in the USA, language ability, and sending country. A logistic regression model revealed that refugees from African sending countries were more likely than Eastern European individuals to experience discrimination, even after controlling for potentially confounding factors. We interpret this finding as evidence of racism and discuss the implications for population health and resettlement practice.

KENNEDY SPACE CENTER, FLA. -- NASA and United Space Alliance (USA) Space Shuttle program managers attend a briefing, part of activities during a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC. Starting third from left are NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, USA Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Space Shuttle Program Manager William Parsons, and USA Associate Program Manager of Ground Operations Andy Allen.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- NASA and United Space Alliance (USA) Space Shuttle program managers attend a briefing, part of activities during a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC. Starting third from left are NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, USA Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Space Shuttle Program Manager William Parsons, and USA Associate Program Manager of Ground Operations Andy Allen.

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians demonstrate the construction of a thermal blanket used in the Shuttle's thermal protection system for USA Vice President and Space Shuttle Program Manager Howard DeCastro (second from left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians demonstrate the construction of a thermal blanket used in the Shuttle's thermal protection system for USA Vice President and Space Shuttle Program Manager Howard DeCastro (second from left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with USA Vice President and Space Shuttle Program Manager Howard DeCastro and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with USA Vice President and Space Shuttle Program Manager Howard DeCastro and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) are briefed on the use of a cold plate in Orbiter Processing Facility Bay 2 by a USA technician (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) are briefed on the use of a cold plate in Orbiter Processing Facility Bay 2 by a USA technician (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility Bay 1, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (right) are briefed by a USA technician (center) on Shuttle processing in the payload bay of orbiter Atlantis. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility Bay 1, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (right) are briefed by a USA technician (center) on Shuttle processing in the payload bay of orbiter Atlantis. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (third from left) watch as a USA technician (right) creates a tile for use in the Shuttle's Thermal Protection System (TPS). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (third from left) watch as a USA technician (right) creates a tile for use in the Shuttle's Thermal Protection System (TPS). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

Evidence-Based Redesign of the COMLEX-USA Series.

PubMed

Gimpel, John R; Horber, Dorothy; Sandella, Jeanne M; Knebl, Janice A; Thornburg, John E

2017-04-01

To ensure that the Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) reflects the evolving practice of osteopathic medicine, the National Board of Osteopathic Medical Examiners has developed new content and format specifications for an enhanced, competency-based examination program to be implemented with COMLEX-USA Level 3 in 2018. This article summarizes the evidence-based design processes that served as the foundation for blueprint development and the evidence supporting its validity. An overview is provided of the blueprint's 2 dimensions: Competency Domains and Clinical Presentations. The authors focus on the evidence that supports interpretation of test scores for the primary and intended purpose of COMLEX-USA, which is osteopathic physician licensure. Important secondary uses and the educational and catalytic effect of assessments are also described. This article concludes with the National Board of Osteopathic Medical Examiners' plans to ensure that the COMLEX-USA series remains current and meets the needs of its stakeholders-the patients who seek care from osteopathic physicians.

The methodological and reporting quality of systematic reviews from China and the USA are similar.

PubMed

Tian, Jinhui; Zhang, Jun; Ge, Long; Yang, Kehu; Song, Fujian

2017-05-01

To compare the methodological and reporting quality of systematic reviews by authors from China and those from the United States (USA). From systematic reviews of randomized trials published in 2014 in English, we randomly selected 100 from China and 100 from the USA. The methodological quality was assessed using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool, and reporting quality assessed using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) tool. Compared with systematic reviews from the USA, those from China were more likely to be a meta-analysis, published in low-impact journals, and a non-Cochrane review. The mean summary Assessing the Methodological Quality of Systematic Reviews score was 6.7 (95% confidence interval: 6.5, 7.0) for reviews from China and 6.6 (6.1, 7.1) for reviews from the USA, and the mean summary Preferred Reporting Items for Systematic Reviews and Meta-analyses score was 21.2 (20.7, 21.6) for reviews from China and 20.6 (19.9, 21.3) for reviews from the USA. The differences in summary quality scores between China and the USA were statistically nonsignificant after adjusting for multiple review factors. The overall methodological and reporting quality of systematic reviews by authors from China are similar to those from the USA, although the quality of systematic reviews from both countries could be further improved. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains isolated from invasive and non-invasive infections from Mexico and the USA during 1999–2010

PubMed Central

Villaseñor-Sierra, Alberto; Katahira, Eva; Jaramillo-Valdivia, Abril N.; de los Angeles Barajas-García, María; Bryant, Amy; Morfín-Otero, Rayo; Márquez-Díaz, Francisco; Tinoco, Juan Carlos; Sánchez-Corona, José; Stevens, Dennis L.

2012-01-01

Summary Objective To compare the prevalence, phenotypes, and genes responsible for erythromycin resistance among Streptococcus pyogenes isolates from Mexico and the USA. Methods Eighty-nine invasive and 378 non-invasive isolates from Mexico, plus 148 invasive, 21 non-invasive, and five unclassified isolates from the USA were studied. Susceptibilities to penicillin, erythromycin, clindamycin, ceftriaxone, and vancomycin were evaluated according to Clinical and Laboratory Standards Institute (CLSI) standards. Phenotypes of erythromycin resistance were identified by triple disk test, and screening for mefA, ermTR, and ermB genes was carried out by PCR. Results All isolates were susceptible to penicillin, ceftriaxone, and vancomycin. Erythromycin resistance was found in 4.9% of Mexican strains and 5.2% of USA strains. Phenotypes in Mexican strains were 95% M and 5% cMLS; in strains from the USA, phenotypes were 33.3% iMLS, 33.3% iMLS-D, and 33.3% M. Erythromycin resistance genes in strains from Mexico were mefA (95%) and ermB (5%); USA strains harbored ermTR (56%), mefA (33%), and none (11%). In Mexico, all erythromycin-resistant strains were non-invasive, whereas 89% of strains from the USA were invasive. Conclusions Erythromycin resistance continues to exist at low levels in both Mexico and the USA, although the genetic mechanisms responsible differ between the two nations. These genetic differences may be related to the invasive character of the S. pyogenes isolated. PMID:22217469

High youth access to movies that contain smoking in Europe compared with the USA

PubMed Central

Hanewinkel, Reiner; Sargent, James D; Karlsdóttir, Sólveig; Jónsson, Stefán Hrafn; Mathis, Federica; Faggiano, Fabrizio; Poelen, Evelien A P; Scholte, Ron; Florek, Ewa; Sweeting, Helen; Hunt, Kate; Morgenstern, Matthis

2013-01-01

Background Based on evidence that exposure to smoking in movies is associated with adolescent smoking, the WHO has called on countries to assign a rating that restricts youth access to such movies. Objective To evaluate youth access to movies that portray smoking in European countries and compare with that in the USA. Methods The authors identified the most commercially successful movies screened in six European countries (Germany, Iceland, Italy, the Netherlands, Poland and UK) and the USA between 2004 and 2009. The authors coded the 464 movies that were screened in both Europe and the USA according to whether or not they portrayed smoking. Results 87% of the movies were ‘youth’ rated in Europe (ratings board classification as suitable for those younger than 16 years) compared to only 67% in the USA (suitable for those younger than 17 years). Smoking was portrayed in 319 (69%) movies. 85% of the movies that portrayed smoking were ‘youth’ rated in Europe compared with only 59% in the USA (p<0.001). Conclusions Tobacco imagery is still common in popular films shown in European countries and the USA. None of the seven countries examined followed the WHO recommendations on restricting youth access to movies that portray smoking. Compared to the USA, European youths have access to substantially more movies in general, and this gives them access to more movies that portray smoking in particular. PMID:22184208

USA Science and Engineering Festival 2014

NASA Image and Video Library

2014-04-25

An attendee of the USA Science and Engineering Festival uses marbles to build a universe consisting of atoms and dark matter. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

ULTRAVIOLET RADIATION DOSE AND AMPHIBIAN DISTRIBUTIONS IN NATIONAL PARKS

EPA Science Inventory

Ultraviolet Radiation Dose and Amphibian Distributions in National Parks. Diamond, S. A., Detenbeck, N. E., USEPA, Duluth, MN, USA, Bradford, D. F., USEPA, Las Vegas, NV, USA, Trenham, P. C., University of California, Davis, CA., USA, Adams, M. J., Corn, P. S., Hossack, B., USGS,...

75 FR 74707 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

...-000. Applicants: Planet Energy (USA) Corp. Description: Planet Energy (USA) Corp. submits tariff filing per 35.1: Planet Energy USA MBR Application to be effective 11/22/2010. Filed Date: 11/22/2010... Numbers: ER11-2167-000. Applicants: Planet Energy (Pennsylvania) Corp. Description: Planet Energy...

PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2010)

NASA Astrophysics Data System (ADS)

Lin, Simon C.; Shen, Stella; Neufeld, Niko; Gutsche, Oliver; Cattaneo, Marco; Fisk, Ian; Panzer-Steindel, Bernd; Di Meglio, Alberto; Lokajicek, Milos

2011-12-01

The International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held at Academia Sinica in Taipei from 18-22 October 2010. CHEP is a major series of international conferences for physicists and computing professionals from the worldwide High Energy and Nuclear Physics community, Computer Science, and Information Technology. The CHEP conference provides an international forum to exchange information on computing progress and needs for the community, and to review recent, ongoing and future activities. CHEP conferences are held at roughly 18 month intervals, alternating between Europe, Asia, America and other parts of the world. Recent CHEP conferences have been held in Prauge, Czech Republic (2009); Victoria, Canada (2007); Mumbai, India (2006); Interlaken, Switzerland (2004); San Diego, California(2003); Beijing, China (2001); Padova, Italy (2000) CHEP 2010 was organized by Academia Sinica Grid Computing Centre. There was an International Advisory Committee (IAC) setting the overall themes of the conference, a Programme Committee (PC) responsible for the content, as well as Conference Secretariat responsible for the conference infrastructure. There were over 500 attendees with a program that included plenary sessions of invited speakers, a number of parallel sessions comprising around 260 oral and 200 poster presentations, and industrial exhibitions. We thank all the presenters, for the excellent scientific content of their contributions to the conference. Conference tracks covered topics on Online Computing, Event Processing, Software Engineering, Data Stores, and Databases, Distributed Processing and Analysis, Computing Fabrics and Networking Technologies, Grid and Cloud Middleware, and Collaborative Tools. The conference included excursions to various attractions in Northern Taiwan, including Sanhsia Tsu Shih Temple, Yingko, Chiufen Village, the Northeast Coast National Scenic Area, Keelung, Yehliu Geopark, and Wulai Aboriginal Village, as well as two banquets held at the Grand Hotel and Grand Formosa Regent in Taipei. The next CHEP conference will be held in New York, the United States on 21-25 May 2012. We would like to thank the National Science Council of Taiwan, the EU ACEOLE project, commercial sponsors, and the International Advisory Committee and the Programme Committee members for all their support and help. Special thanks to the Programme Committee members for their careful choice of conference contributions and enormous effort in reviewing and editing about 340 post conference proceedings papers. Simon C Lin CHEP 2010 Conference Chair and Proceedings Editor Taipei, Taiwan November 2011 Track Editors/ Programme Committee Chair Simon C Lin, Academia Sinica, Taiwan Online Computing Track Y H Chang, National Central University, Taiwan Harry Cheung, Fermilab, USA Niko Neufeld, CERN, Switzerland Event Processing Track Fabio Cossutti, INFN Trieste, Italy Oliver Gutsche, Fermilab, USA Ryosuke Itoh, KEK, Japan Software Engineering, Data Stores, and Databases Track Marco Cattaneo, CERN, Switzerland Gang Chen, Chinese Academy of Sciences, China Stefan Roiser, CERN, Switzerland Distributed Processing and Analysis Track Kai-Feng Chen, National Taiwan University, Taiwan Ulrik Egede, Imperial College London, UK Ian Fisk, Fermilab, USA Fons Rademakers, CERN, Switzerland Torre Wenaus, BNL, USA Computing Fabrics and Networking Technologies Track Harvey Newman, Caltech, USA Bernd Panzer-Steindel, CERN, Switzerland Antonio Wong, BNL, USA Ian Fisk, Fermilab, USA Niko Neufeld, CERN, Switzerland Grid and Cloud Middleware Track Alberto Di Meglio, CERN, Switzerland Markus Schulz, CERN, Switzerland Collaborative Tools Track Joao Correia Fernandes, CERN, Switzerland Philippe Galvez, Caltech, USA Milos Lokajicek, FZU Prague, Czech Republic International Advisory Committee Chair: Simon C. Lin , Academia Sinica, Taiwan Members: Mohammad Al-Turany , FAIR, Germany Sunanda Banerjee, Fermilab, USA Dario Barberis, CERN & Genoa University/INFN, Switzerland Lothar Bauerdick, Fermilab, USA Ian Bird, CERN, Switzerland Amber Boehnlein, US Department of Energy, USA Kors Bos, CERN, Switzerland Federico Carminati, CERN, Switzerland Philippe Charpentier, CERN, Switzerland Gang Chen, Institute of High Energy Physics, China Peter Clarke, University of Edinburgh, UK Michael Ernst, Brookhaven National Laboratory, USA David Foster, CERN, Switzerland Merino Gonzalo, CIEMAT, Spain John Gordon, STFC-RAL, UK Volker Guelzow, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany John Harvey, CERN, Switzerland Frederic Hemmer, CERN, Switzerland Hafeez Hoorani, NCP, Pakistan Viatcheslav Ilyin, Moscow State University, Russia Matthias Kasemann, DESY, Germany Nobuhiko Katayama, KEK, Japan Milos Lokajícek, FZU Prague, Czech Republic David Malon, ANL, USA Pere Mato Vila, CERN, Switzerland Mirco Mazzucato, INFN CNAF, Italy Richard Mount, SLAC, USA Harvey Newman, Caltech, USA Mitsuaki Nozaki, KEK, Japan Farid Ould-Saada, University of Oslo, Norway Ruth Pordes, Fermilab, USA Hiroshi Sakamoto, The University of Tokyo, Japan Alberto Santoro, UERJ, Brazil Jim Shank, Boston University, USA Alan Silverman, CERN, Switzerland Randy Sobie , University of Victoria, Canada Dongchul Son, Kyungpook National University, South Korea Reda Tafirout , TRIUMF, Canada Victoria White, Fermilab, USA Guy Wormser, LAL, France Frank Wuerthwein, UCSD, USA Charles Young, SLAC, USA

Evaluation of indigenous Lotus species for the western USA for rangeland revegetation and restoration

USDA-ARS?s Scientific Manuscript database

Semiarid rangelands in the western USA are facing serious challenges related to past mismanagement, invasive weedy species, wildfires, and climatic change. Leguminous forbs that are native to the western USA are of interest for rangeland revegetation and restoration because they provide biologicall...

75 FR 13484 - Foreign-Trade Zone 22; Temporary/Interim Manufacturing Authority; LG Electronics Mobilecomm USA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

... DEPARTMENT OF COMMERCE [Docket T-1-2010] Foreign-Trade Zones Board Foreign-Trade Zone 22; Temporary/Interim Manufacturing Authority; LG Electronics Mobilecomm USA, Inc. (Cell Phones); Notice of.../ interim manufacturing (T/IM) authority, on behalf of LG Electronics Mobilecomm USA, Inc. (LGEMU), to...

78 FR 69659 - Chevron U.S.A. Inc. v. Kinder Morgan Louisiana Pipeline LLC; Notice of Complaint

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP14-161-000] Chevron U.S.A... Commission (Commission), 18 CFR 385.206, Chevron U.S.A. Inc. (Chevron or Complainant), filed a complaint..., Commission policy, and contractual obligations. [[Page 69660

76 FR 21407 - Manufacturer of Controlled Substances Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

... 3, 2010, 75 FR 75497, Siegfried (USA), Inc., 33 Industrial Park Road, Pennsville, New Jersey 08070... the factors in 21 U.S.C. 823(a) and determined that the registration of Siegfried (USA), Inc. to.... DEA has investigated Siegfried (USA), Inc. to ensure that the company's registration is consistent...

76 FR 21916 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... December 29, 2010, 75 FR 82073, Siegfried (USA), Inc., 33 Industrial Park Road, Pennsville, New Jersey... registration of Siegfried (USA), Inc. to manufacture the listed basic classes of controlled substances is consistent with the public interest at this time. DEA has investigated Siegfried (USA), Inc. to ensure that...

75 FR 44287 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-28

..., 2010, (75 FR 14189), Siegfried (USA), 33 Industrial Park Road, Pennsville, New Jersey 08070, made... determined that the registration of Siegfried (USA) to manufacture the listed basic classes of controlled substances is consistent with the public interest at this time. DEA has investigated Siegfried (USA) to...

75 FR 62570 - Manufacturer of Controlled Substances; Notice of Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-12

..., 2010 (75 FR 36683), Siegfried (USA), 33 Industrial Park Road, Pennsville, New Jersey 08070, made... considered the factors in 21 U.S.C. 823(a) and determined that the registration of Siegfried (USA) to.... DEA has investigated Siegfried (USA) to ensure that the company's registration is consistent with the...

77 FR 31643 - Siltronic Corporation FAB1 Plant Including On-Site Leased Workers From Express Temporaries...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... Secure Solutions USA, SBM Management Services, LP, ALSCO Portland Industrial, VWR International, Inc... G4S Secure Solutions USA, SBM Management Services, LP, Alsco Portland Industrial, VWR International... workers from Express Temporaries, Aerotek Commercial Staffing, G4S Secure Solutions USA, SBM Management...

76 FR 67730 - Ocean Transportation Intermediary License Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

... Type: New OFF License LF Freight USA LLC dba LF Logistics dba LF Freight dba IDS Logistics USA, dba IDS Freight Services, dba AGI Logistics USA, dba AGI Logistics, 230-59 International Airport Center Blvd., 270... Individual), Caetano R. Lopes, Vice President, Application Type: Add NVO Service Eztrans Logistics Ltd. (NVO...

Inferring the annual migration patterns of fall armyworm(Lepidoptera: Noctuidae) in the United States from mitochondrial haplotypes

USDA-ARS?s Scientific Manuscript database

1. Regions of southern Florida, USA and southern Texas, USA (extending into Mexico)provide the source populations for virtually all fall armyworm infestations affecting the continental USA. Understanding how these overwintering populations annually disperse is important to efforts to predict and con...

International Symposium on Air Breathing Engines (5th)

DTIC Science & Technology

1981-05-29

Marquardt Co., USA 22 Flowfield Studies of Dump Combustors Raghunath S. Boray, Wright Patterson AFB, USA and Cherng Chang, Breham Laboratory, USA 23 A Ramjet...Bending Loads R. Padmanabhan, K. Ramachandra, V. Maruthi and B.J. Raghunath , Gas Turbine Research Establishment, Bangalore, India 56 Influence of O-Rings

Distribution, hosts and identification of Meloidogyne partityla in the USA

USDA-ARS?s Scientific Manuscript database

Pecan, Carya illinoensis, is an economically important nut crop and member of the Juglandaceae native to the southern USA. Discovered in South Africa in 1986, Meloidogyne partityla was first found infecting pecan in USA in 1996 and currently occurs in Texas, New Mexico, Georgia, Arizona, Oklahoma a...

"USA Today": Can the Nation's Newspaper Survive?

ERIC Educational Resources Information Center

Wicks, Robert H.

The failure of 17 newspaper markets between 1957 and 1975 raises the question of whether the 1982 entrance of "USA Today" into the newspaper market demonstrated fiscal prudence. A 20-month advertising content analysis was conducted to assess advertising trends in "USA Today." These data were compared with industry statistics…

"USA Today": Comparative Analysis with Two National and Two Los Angeles Daily Newspapers. Research Bulletin.

ERIC Educational Resources Information Center

Ames, Steve; And Others

Sections of the newspaper "USA Today" were compared with corresponding sections of four major newspapers--the "New York Times," the "Wall Street Journal," the "Los Angeles Herald Examiner," and the "Los Angeles Times"--to determine what editorial components made "USA Today" different and…

Pest status of the brown marmorated stink bug, Halyomorpha halys (Stal) in the USA

USDA-ARS?s Scientific Manuscript database

Since its initial discovery in Allentown, PA, USA, the brown marmorated stink bug (BMSB), Halyomorpha halys (Heteroptera: Pentatomidae), has now officially been detected in 37 states and the District of Columbia in the USA. Isolated populations also exist in Switzerland and Canada. This Asian spec...

78 FR 49546 - Importer of Controlled Substances; Notice of Application; Siegfried USA, LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Siegfried USA, LLC This is notice that on June 10, 2013, Siegfried USA, LLC., 33 Industrial Park Road, Pennsville, New Jersey 08070, made application by letter to the Drug Enforcement Administration...

78 FR 46613 - Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-01

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 10, 2013, Siegfried (USA), LLC., 33 Industrial Park Road...

78 FR 5500 - Manufacturer of Controlled Substances, Notice of Application; Siegfried (USA)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances, Notice of Application; Siegfried (USA) Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 19, 2012, Siegfried (USA), 33 Industrial Park Road, Pennsville...

78 FR 32458 - Manufacturer of Controlled Substances; Notice of Application; Siegfried USA, LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried USA, LLC Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on April 18, 2013, Siegfried USA, LLC., 33 Industrial Park Road...

31 CFR 537.529 - Exportation or reexportation of financial services to Burma authorized.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism (USA PATRIOT) Act of 2001 (Pub. L. 107-56) (USA PATRIOT Act) do not apply to the operation of correspondent accounts... the USA PATRIOT Act. See 31 CFR 1010.610(c). ...

77 FR 70825 - Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-27

... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on November 5, 2012, Siegfried (USA) LLC, 33 Industrial Park Road...

75 FR 67775 - Compass Group USA, Inc., Canteen, Webster City, Iowa; Notice of Negative Determination on...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-03

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,503] Compass Group USA, Inc... Services provided services (janitorial, maintenance, and hazardous waste disposal) that were directly... workers cannot be considered employees of Electrolux, but only of the subject firm, Compass Group USA...

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, while Greg Harlow, with United Space Alliance (USA) (above) threads a camera under the tiles of the orbiter Endeavour, Peggy Ritchie, USA, (behind the stand) and NASA’s Richard Parker (seated) watch the images on a monitor to inspect for corrosion.

NASA Image and Video Library

2003-09-04

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, while Greg Harlow, with United Space Alliance (USA) (above) threads a camera under the tiles of the orbiter Endeavour, Peggy Ritchie, USA, (behind the stand) and NASA’s Richard Parker (seated) watch the images on a monitor to inspect for corrosion.

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, while Greg Harlow, with United Space Alliance (USA), (above) threads a camera under the tiles of the orbiter Endeavour, NASA’s Richard Parker (below left) and Peggy Ritchie, with USA, (at right) watch the images on a monitor to inspect for corrosion.

NASA Image and Video Library

2003-09-04

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, while Greg Harlow, with United Space Alliance (USA), (above) threads a camera under the tiles of the orbiter Endeavour, NASA’s Richard Parker (below left) and Peggy Ritchie, with USA, (at right) watch the images on a monitor to inspect for corrosion.

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, while Greg Harlow, with United Space Alliance (USA), (above) threads a camera under the tiles of the orbiter Endeavour, Peggy Ritchie, with USA, (behind the stand) and NASA’s Richard Parker watch the images on a monitor to inspect for corrosion.

NASA Image and Video Library

2003-09-04

KENNEDY SPACE CENTER, FLA. - In the Orbiter Processing Facility, while Greg Harlow, with United Space Alliance (USA), (above) threads a camera under the tiles of the orbiter Endeavour, Peggy Ritchie, with USA, (behind the stand) and NASA’s Richard Parker watch the images on a monitor to inspect for corrosion.

Pricing behavior of USA exporter in wheat international market

NASA Astrophysics Data System (ADS)

Wibowo, R. P.; Sumono; Iddrisu, Y.; Darus, M.; Sihombing, L. P.; Jufri

2018-02-01

The number of wheat producing countries is changing over time. It is expected the change in wheat supply will lead world wheat market become more competitive and reduce market power of major exporter country. This paper tries to identify and examined the degree of market power on wheat international market for USA by using the Pricing to Market (PTM) method. USA is the biggest producer and exporter in wheat market. The PTM method found that USA impose noncompetitive strategy by applying price discrimination and apply market power to their importer country.

Summary of ARI Research on Remotely Monitored Sensors

DTIC Science & Technology

1980-07-01

I NAVY PFRSONNEL R AND 0 CENTER/ I US ARMY AVN ENbINEERING FLIGHT ACTIVIIY ATTN8 SAVTE- TD SoFc OF NAVAL RESEARCH PERSONNEL AND TRAINING RESEARCH...LABS ATTN: LTL- TD -S I USA MORILITY EWUIPMENT R AND 0 COMO ATTNS ODMUE-TO I NIGHT VISION LAH ATTN: UHSEL-NV-SUU I USA TRAINING BUAHD I USA HUMAN...I PURDUE UNIV DLPT OF PSYCMOLOGICAL SCIE.NCES 1 05A MOHILITY EWI,1PMENT w AND 0 LUMMANL) ATTNt URDME-1rG IHQ . USA MDW ATTN; ANPE-vE It D A US ARMY

Two Distinct Clones of Methicillin-Resistant Staphylococcus aureus (MRSA) with the Same USA300 Pulsed-Field Gel Electrophoresis Profile: a Potential Pitfall for Identification of USA300 Community-Associated MRSA▿

PubMed Central

Larsen, Anders Rhod; Goering, Richard; Stegger, Marc; Lindsay, Jodi A.; Gould, Katherine A.; Hinds, Jason; Sørum, Marit; Westh, Henrik; Boye, Kit; Skov, Robert

2009-01-01

Analysis of methicillin-resistant Staphylococcus aureus (MRSA) characterized as USA300 by pulsed-field gel electrophoresis identified two distinct clones. One was similar to community-associated USA300 MRSA (ST8-IVa, t008, and Panton-Valentine leukocidin positive). The second (ST8-IVa, t024, and PVL negative) had different molecular characteristics and epidemiology, suggesting independent evolution. We recommend spa typing and/or PCR to discriminate between the two clones. PMID:19759225

International Program and Local Organizing Committees

NASA Astrophysics Data System (ADS)

2012-12-01

International Program Committee Dionisio Bermejo (Spain) Roman Ciurylo (Poland) Elisabeth Dalimier (France) Alexander Devdariani (Russia) Milan S Dimitrijevic (Serbia) Robert Gamache (USA) Marco A Gigosos (Spain) Motoshi Goto (Japan) Magnus Gustafsson (Sweden) Jean-Michel Hartmann (France) Carlos Iglesias (USA) John Kielkopf (USA) John C Lewis (Canada) Valery Lisitsa (Russia) Eugene Oks (USA) Christian G Parigger (USA) Gillian Peach (UK) Adriana Predoi-Cross (Canada) Roland Stamm (Germany) Local Organizing Committee Nikolay G Skvortsov (Chair, St Petersburg State University) Evgenii B Aleksandrov (Ioffe Physico-Technical Institute, St Petersburg) Vadim A Alekseev (Scientific Secretary, St Petersburg State University) Sergey F Boureiko (St.Petersburg State University) Yury N Gnedin (Pulkovo Observatory, St Petersburg) Alexander Z Devdariani (Deputy Chair, St Petersburg State University) Alexander P Kouzov (Deputy Chair, St Petersburg State University) Nikolay A Timofeev (St Petersburg State University)

Comparing perceptions of dental aesthetics in the USA with those in eleven ethnic groups.

PubMed

Cons, N C; Jenny, J

1994-12-01

The Standard DAI is an orthodontic index based on perceptions of dental aesthetics in the USA. The Standard DAI is a regression equation linking perceptions of the social acceptability of dental aesthetics with the objective intraoral measurements of ten occlusal traits. Since the Standard DAI is based on perceptions of dental aesthetics in the USA it can be used without modification only where perceptions of dental aesthetics are similar to those in the USA. This study was designed to determine whether perceptions of dental aesthetics of students in eleven diverse ethnic groups are similar to those of students in the USA. The same 25 stimuli (photographs of dental configurations, a subset of the 200 stimuli used in deriving the Standard DAI equation) were rated for dental aesthetics by Australian, Chinese, German, Japanese, Korean, Latvian, Native American, Singaporean Chinese, Singaporean Indian, Singaporean Malay, and Thai students. Their ratings were compared with the ratings of the same 25 stimuli by students in the USA. Spearman rank-order correlations ranged from 0.84 to 0.94. These correlations are sufficiently high to show that perceptions of dental aesthetics in all eleven ethnic groups are very similar to the perceptions of USA students. Therefore the Standard DAI can be used without modification in all eleven ethnic groups.

Comparing perceptions of dental aesthetics in the USA with those in eleven ethnic groups.

PubMed

Cons, N C; Jenny, J

1994-10-01

The Standard DAI is an orthodontic index based on perceptions of dental aesthetics in the USA. The Standard DAI is a regression equation linking perceptions of the social acceptability of dental aesthetics with the objective intraoral measurements of ten occlusal traits. Since the Standard DAI is based on perceptions of dental aesthetics in the USA it can be used without modification only where perceptions of dental aesthetics are similar to those in the USA. This study was designed to determine whether perceptions of dental aesthetics of students in eleven diverse ethnic groups are similar to those of students in the USA. The same 25 stimuli (photographs of dental configurations, a subset of the 200 stimuli used in deriving the Standard DAI equation) were rated for dental aesthetics by Australian, Chinese, German, Japanese, Korean, Latvian, Native American, Singaporean Chinese, Singaporean Indian, Singaporean Malay, and Thai students. Their ratings were compared with the ratings of the same 25 stimuli by students in the USA. Spearman rank-order correlations ranged from 0.84 to 0.94. These correlations are sufficiently high to show that perceptions of dental aesthetics in all eleven ethnic groups are very similar to the perceptions of USA students. Therefore the Standard DAI can be used without modification in all eleven ethnic groups.

Incremental Aerodynamic Coefficient Database for the USA2

NASA Technical Reports Server (NTRS)

Richardson, Annie Catherine

2016-01-01

In March through May of 2016, a wind tunnel test was conducted by the Aerosciences Branch (EV33) to visually study the unsteady aerodynamic behavior over multiple transition geometries for the Universal Stage Adapter 2 (USA2) in the MSFC Aerodynamic Research Facility's Trisonic Wind Tunnel (TWT). The purpose of the test was to make a qualitative comparison of the transonic flow field in order to provide a recommended minimum transition radius for manufacturing. Additionally, 6 Degree of Freedom force and moment data for each configuration tested was acquired in order to determine the geometric effects on the longitudinal aerodynamic coefficients (Normal Force, Axial Force, and Pitching Moment). In order to make a quantitative comparison of the aerodynamic effects of the USA2 transition geometry, the aerodynamic coefficient data collected during the test was parsed and incorporated into a database for each USA2 configuration tested. An incremental aerodynamic coefficient database was then developed using the generated databases for each USA2 geometry as a function of Mach number and angle of attack. The final USA2 coefficient increments will be applied to the aerodynamic coefficients of the baseline geometry to adjust the Space Launch System (SLS) integrated launch vehicle force and moment database based on the transition geometry of the USA2.

Emergence of Resistance among USA300 Methicillin-Resistant Staphylococcus aureus Isolates Causing Invasive Disease in the United States▿

PubMed Central

McDougal, Linda K.; Fosheim, Gregory E.; Nicholson, Ainsley; Bulens, Sandra N.; Limbago, Brandi M.; Shearer, Julia E. S.; Summers, Anne O.; Patel, Jean B.

2010-01-01

USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates are usually resistant only to oxacillin, erythromycin, and, increasingly, levofloxacin. Of these, oxacillin and levofloxacin resistances are chromosomally encoded. Plasmid-mediated clindamycin, mupirocin, and/or tetracycline resistance has been observed among USA300 isolates, but these descriptions were limited to specific patient populations or isolated occurrences. We examined the antimicrobial susceptibilities of invasive MRSA isolates from a national surveillance population in order to identify USA300 isolates with unusual, possibly emerging, plasmid-mediated antimicrobial resistance. DNA from these isolates was assayed for the presence of resistance determinants and the presence of a pSK41-like conjugative plasmid. Of 823 USA300 isolates, 72 (9%) were tetracycline resistant; 69 of these were doxycycline susceptible and tetK positive, and 3 were doxycycline resistant and tetM positive. Fifty-one (6.2%) isolates were clindamycin resistant and ermC positive; 22 (2.7%) isolates were high-level mupirocin resistant (mupA positive); 5 (0.6%) isolates were trimethoprim-sulfamethoxazole (TMP-SMZ) resistant, of which 4 were dfrA positive; and 7 (0.9%) isolates were gentamicin resistant and aac6′-aph2″ positive. Isolates with pSK41-like plasmids (n = 24) were positive for mupA (n = 19), dfrA (n = 6), aac6′-aph2″ (n = 6), tetM (n = 2), and ermC (n = 8); 20 pSK41-positive isolates were positive for two or more resistance genes. Conjugative transfer of resistance was demonstrated between four gentamicin- and mupirocin-resistant and three gentamicin- and TMP-SMZ-resistant USA300 isolates; transconjugants harbored a single pSK41-like plasmid, which was PCR positive for aac6′-aph2″ and either mupA and/or dfrA. USA300 and USA100 isolates from the same state with identical resistance profiles contained pSK41-like plasmids with indistinguishable restriction and Southern blot profiles, suggesting horizontal plasmid transfer between USA100 and USA300 isolates. PMID:20585117

Relationships between the Comprehensive Osteopathic Medical Achievement Test (COMAT) subject examinations and the COMLEX-USA Level 2-Cognitive Evaluation.

PubMed

Li, Feiming; Kalinowski, Kevin E; Song, Hao; Bates, Bruce P

2014-09-01

The relationship between the Comprehensive Osteopathic Medical Achievement Test (COMAT) series of subject examinations and the Comprehensive Osteopathic Medical Licensing Examination-USA Level 2-Cognitive Evaluation (COMLEX-USA Level 2-CE) has not been thoroughly examined. To investigate the factors associated with performance on COMAT subject examinations and how COMAT scores correlate with COMLEX-USA Level 2-CE scores. We examined scores of participants from 2 COMAT examination cycles in 2011 and 2012. According to surveys, most schools used COMAT scores in clerkship and clinical rotation evaluation, which were classified as being used for "high-stakes" purposes. We matched first-attempt COMAT scores with first-attempt COMLEX-USA Level 2-CE scores, and we conducted correlation analyses between the scores from the 7 COMAT subject examinations, as well as between COMAT and COMLEX-USA Level 2-CE scores. Multiple linear regression analyses were performed to investigate how much variance in COMLEX-USA Level 2-CE scores was explained by COMAT scores. In 2011 and 2012, respectively, 3751 and 3786 COMAT candidates had COMLEX-USA Level 2-CE scores (53.0% and 93.9%, respectively, had ⩾1 high-stakes COMAT score). Intercorrelations between COMAT scores were low to moderate (r=0.27-0.53), as hypothesized. Correlations between COMAT and Level 2-CE scores were moderate to high, with the highest correlations for internal medicine COMAT scores (r=0.63-0.65). All regressions showed internal medicine scores as the strongest predictor of Level 2-CE performance. Groups with high-stakes scores had larger adjusted coefficients of determination than those with low-stakes scores (eg, R(2)=0.63 vs 0.52, respectively, in 2011). For 2012 candidates with high-stakes scores, all predictors were statistically significant. The COMAT subject examination scores were moderately intercorrelated, as hypothesized, with higher correlations between COMAT and COMLEX-USA Level 2-CE scores. The COMAT performance was predictive of COMLEX-USA Level 2-CE performance. © 2014 The American Osteopathic Association.

Transmission of multidrug-resistant tuberculosis in the USA: a cross-sectional study.

PubMed

Moonan, Patrick K; Teeter, Larry D; Salcedo, Katya; Ghosh, Smita; Ahuja, Shama D; Flood, Jennifer; Graviss, Edward A

2013-09-01

Multidrug-resistant (MDR) tuberculosis is a potential threat to tuberculosis elimination, but the extent of MDR tuberculosis disease in the USA that is attributable to transmission within the country is unknown. We assessed transmission of MDR tuberculosis and potential contributing factors in the USA. In a cross-sectional study, clinical, demographic, epidemiological, and Mycobacterium tuberculosis genotype data were obtained during routine surveillance of all verified cases of MDR tuberculosis reported from eight states in the USA (California from Jan 1, 2007, to Dec 31, 2009; Texas from Jan 1, 2007, to March 31, 2009; and the states of Colorado, Maryland, Massachusetts, New York, Tennessee, and Washington from Jan 1, 2007 to Dec 31, 2008). In-depth interviews and health-record abstraction were done for all who consented to ascertain potential interpersonal connections. 168 cases of MDR tuberculosis were reported in the eight states during our study period. 92 individuals (55%) consented to in-depth interview. 20 (22%) of these individuals developed MDR tuberculosis as a result of transmission in the USA; a source case was identified for eight of them (9%). 20 individuals (22%) had imported active tuberculosis (ie, culture-confirmed disease within 3 months of entry into the USA). 38 (41%) were deemed to have reactivation of disease, of whom 14 (15%) had a known previous episode of tuberculosis outside the USA. Five individuals (5%) had documented treatment of a previous episode in the USA, and so were deemed to have relapsed. For nine cases (10%), insufficient evidence was available to definitively classify reason for presentation. About a fifth of cases of MDR tuberculosis in the USA can be linked to transmission within the country. Many individuals acquire MDR tuberculosis before entry into the USA. MDR tuberculosis needs to be diagnosed rapidly to reduce potential infectious periods, and clinicians should consider latent tuberculosis infection treatment-tailored to the results of drug susceptibility testing of the putative source case-for exposed individuals. Centers for Disease Control and Prevention. Copyright © 2013 Elsevier Ltd. All rights reserved.

Comparison of COMLEX-USA scores, medical school performance, and preadmission variables between women and men.

PubMed

Dixon, Donna

2015-04-01

Previous studies by the author showed differences in preadmission variables and Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) scores between women and men at the New York Institute of Technology College of Osteopathic Medicine (NYIT-COM). It is pertinent to reexamine the preadmission variables, medical school performance, and COMLEX-USA scores of women and men to determine whether these differences still exist. To examine the relationship between student sex and performance on COMLEX-USA Level 1 and Level 2-Cognitive Evaluation (CE), performance during medical school, and preadmission academic variables at NYIT-COM. Scores on COMLEX-USA Level 1 and COMLEX-USA Level 2-CE, grades in all courses taken during the first 2 years of medical school, the National Board of Osteopathic Medical Examiners' clinical science subject examination scores, Medical College Admission Test (MCAT) scores, and undergraduate grade point averages (GPAs) were compared between women and men in the classes graduating between 2009 and 2012. Data from 748 students were analyzed. Men had statistically significantly higher scores than women on COMLEX-USA Level 1 in 2009 (540 vs 500; P<.001) and 2010 (537 vs 496; P<.001). No statistically significant difference in COMLEX-USA Level 2-CE scores was found between women and men. The performance of women and men was comparable during the first 2 years of medical school and on clinical science subject examinations in years 3 and 4. Men had statistically significantly higher MCAT scores than women, but no statistically significant differences were found between women's and men's undergraduate GPAs. Men were found to have higher scores than women on COMLEX-USA Level 1 and the MCAT. However, the reasons behind these data have yet to be elucidated. Although a stronger background in basic science could explain the discrepancy in scores between women and men, women were found to have equally high science GPAs and performed comparably to men in osteopathic medical school. The results were in agreement with previous studies at NYIT-COM.

Predictors of scoring at least 600 on COMLEX-USA Level 1: successful preparation strategies.

PubMed

Vora, Aditya; Maltezos, Nathan; Alfonzo, Lauren; Hernandez, Nilda; Calix, Erica; Fernandez, M Isabel

2013-02-01

Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) Level 1 scores are an important criterion used by residency directors to make residency placement decisions. To explore the association between scoring at least 600 on COMLEX-USA Level 1 and grade point average (GPA), scores on the Medical College Admission Test (MCAT), and different test preparation strategies. Third-year osteopathic medical students at Nova Southeastern University were invited to complete a self-administered survey regarding their COMLEX-USA preparation strategies and to provide consent for the researchers to access their preclinical GPA and their MCAT and COMLEX-USA scores. Descriptive analyses were conducted to understand examination preparation procedures and resources used, and bivariate analyses were conducted to identify the statisically significant predictors of scoring 600 or higher. Two separate logistic regressions were also run. The first included all of the statisically significant factors that emerged from the bivariate analyses, and the second examined which candidate predictors remained statistically significant once the effects of GPA and MCAT scores were removed. One hundred twenty-two students completed the survey, and 113 (93%) provided informed consent to access their preclinical GPA and their MCAT and COMLEX-USA scores. In the first regression, scoring 600 or higher was associated with a higher GPA (P<.02), a higher MCAT score (P<.05), earlier preparation initiation (P<.05), and not ranking the Comprehensive Osteopathic Medical Self-Assessment Examination (COMSAE) as the most helpful practice examination (P<.04). In the second regression, scoring 600 or higher was associated with earlier initiation of examination preparation (P<.01) and not ranking COMBANK (question bank for COMLEX-USA) as the most helpful question bank (P<.03). Among the different examination preparation methods, the specific resources ranked as most helpful were First Aid for the USMLE (United States Medical Licensing Examination) (review book), the COMSAE (practice examination); COMBANK (question bank); and Kaplan USMLE (lecture videos). Preclinical GPA and MCAT scores continue to be important predictors of scoring at least 600 on COMLEX-USA Level 1. However, the findings underscore the importance of maintaining a high GPA during the first 2 years of medical school and initiating COMLEX-USA preparation early.

Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains isolated from invasive and non-invasive infections from Mexico and the USA during 1999-2010.

PubMed

Villaseñor-Sierra, Alberto; Katahira, Eva; Jaramillo-Valdivia, Abril N; Barajas-García, María de los Angeles; Bryant, Amy; Morfín-Otero, Rayo; Márquez-Díaz, Francisco; Tinoco, Juan Carlos; Sánchez-Corona, José; Stevens, Dennis L

2012-03-01

To compare the prevalence, phenotypes, and genes responsible for erythromycin resistance among Streptococcus pyogenes isolates from Mexico and the USA. Eighty-nine invasive and 378 non-invasive isolates from Mexico, plus 148 invasive, 21 non-invasive, and five unclassified isolates from the USA were studied. Susceptibilities to penicillin, erythromycin, clindamycin, ceftriaxone, and vancomycin were evaluated according to Clinical and Laboratory Standards Institute (CLSI) standards. Phenotypes of erythromycin resistance were identified by triple disk test, and screening for mefA, ermTR, and ermB genes was carried out by PCR. All isolates were susceptible to penicillin, ceftriaxone, and vancomycin. Erythromycin resistance was found in 4.9% of Mexican strains and 5.2% of USA strains. Phenotypes in Mexican strains were 95% M and 5% cMLS; in strains from the USA, phenotypes were 33.3% iMLS, 33.3% iMLS-D, and 33.3% M. Erythromycin resistance genes in strains from Mexico were mefA (95%) and ermB (5%); USA strains harbored ermTR (56%), mefA (33%), and none (11%). In Mexico, all erythromycin-resistant strains were non-invasive, whereas 89% of strains from the USA were invasive. Erythromycin resistance continues to exist at low levels in both Mexico and the USA, although the genetic mechanisms responsible differ between the two nations. These genetic differences may be related to the invasive character of the S. pyogenes isolated. Copyright © 2011 International Society for Infectious Diseases. All rights reserved.

Toward an Understanding of the Evolution of Staphylococcus aureus Strain USA300 during Colonization in Community Households

PubMed Central

Uhlemann, Anne-Catrin; Kennedy, Adam D.; Martens, Craig; Porcella, Stephen F.; DeLeo, Frank R.; Lowy, Franklin D.

2012-01-01

Staphylococcus aureus is a frequent cause of serious infections and also a human commensal. The emergence of community-associated methicillin-resistant S. aureus led to a dramatic increase in skin and soft tissue infections worldwide. This epidemic has been driven by a limited number of clones, such as USA300 in the United States. To better understand the extent of USA300 evolution and diversification within communities, we performed comparative whole-genome sequencing of three clinical and five colonizing USA300 isolates collected longitudinally from three unrelated households over a 15-month period. Phylogenetic analysis that incorporated additional geographically diverse USA300 isolates indicated that all but one likely arose from a common recent ancestor. Although limited genetic adaptation occurred over the study period, the greatest genetic heterogeneity occurred between isolates from different households and within one heavily colonized household. This diversity allowed for a more accurate tracking of interpersonal USA300 transmission. Sequencing of persisting USA300 isolates revealed mutations in genes involved in major aspects of S. aureus function: adhesion, cell wall biosynthesis, virulence, and carbohydrate metabolism. Genetic variations also included accumulation of multiple polymorphisms within select genes of two multigene operons, suggestive of small genome rearrangements rather than de novo single point mutations. Such rearrangements have been underappreciated in S. aureus and may represent novel means of strain variation. Subtle genetic changes may contribute to USA300 fitness and persistence. Elucidation of small genome rearrangements reveals a potentially new and intriguing mechanism of directed S. aureus genome diversification in environmental niches and during pathogen–host interactions. PMID:23104992

Increases in multiple psychiatric disorders in parents and grandparents of patients with bipolar disorder from the USA compared with The Netherlands and Germany.

PubMed

Post, Robert M; Leverich, Gabriele S; Kupka, Ralph; Keck, Paul E; McElroy, Susan L; Altshuler, Lori L; Frye, Mark A; Rowe, Michael; Grunze, Heinz; Suppes, Trisha; Nolen, Willem A

2015-10-01

We previously found that compared with Europe more parents of the USA patients were positive for a mood disorder, and that this was associated with early onset bipolar disorder. Here we examine family history of psychiatric illness in more detail across several generations. A total of 968 outpatients (average age 41) with bipolar disorder from four sites in the USA and three in the Netherlands and Germany (abbreviated as Europe) gave informed consent and provided detailed demographic and family history information on a patient questionnaire. Family history of psychiatric illness (bipolar disorder, unipolar depression, suicide attempt, alcohol abuse, substance abuse, and other illness) was collected for each parent, four grandparents, siblings, and children. Parents of the probands with bipolar disorder from the USA compared with Europe had a significantly higher incidence of both unipolar and bipolar mood disorders, as well as each of the other psychiatric conditions listed above. With a few exceptions, this burden of psychiatric disorders was also significantly greater in the grandparents, siblings, and children of the USA versus European patients. The increased complexity of psychiatric illness and its occurrence over several generations in the families of patients with bipolar disorder from the USA versus Europe could be contributing to the higher incidence of childhood onsets and greater virulence of illness in the USA compared with Europe. These data are convergent with others suggesting increased both genetic and environmental risk in the USA, but require replication in epidemiologically-derived populations with data based on interviews of the family members.

78 FR 32367 - Approval of Subzone Status; Teva Pharmaceuticals USA, Inc.; North Wales, Chalfont, Kutztown and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [S-32-2013] Approval of Subzone Status; Teva Pharmaceuticals USA, Inc.; North Wales, Chalfont, Kutztown and Sellersville, Pennsylvania On March 18, 2013, the... activation limit of FTZ 35, on behalf of Teva Pharmaceuticals USA, Inc., in North Wales, Chalfont, Kutztown...

75 FR 53638 - Approval for Manufacturing Authority; Foreign-Trade Zone 22; LG Electronics Mobilecomm USA, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... Authority; Foreign-Trade Zone 22; LG Electronics Mobilecomm USA, Inc. (Cell Phone Kitting and Distribution... authority on behalf of LG Electronics Mobilecomm USA, Inc. (LGEMU), within FTZ 22 in Bolingbrook, Illinois... application for manufacturing authority under zone procedures within FTZ 22 on behalf of LG Electronics...

76 FR 11228 - Energy Conservation Program for Consumer Products: Notice of Petition for Waiver of LG...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-01

... Conservation Program for Consumer Products: Notice of Petition for Waiver of LG Electronics USA, Inc. From the... notice announces receipt of and publishes the LG Electronics USA, Inc. (LG) petition for waiver and... is: John I. Taylor, Vice President, Government Relations and Communications, LG Electronics USA, Inc...

76 FR 65710 - Decision and Order Amending Waivers Granted to Mitsubishi Electric & Electronics USA, Inc. From...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... DEPARTMENT OF ENERGY Office of Energy Efficiency and Renewable Energy [Case No. CAC-037] Decision and Order Amending Waivers Granted to Mitsubishi Electric & Electronics USA, Inc. From the Department... Efficiency and Renewable Energy. Decision and Order In the Matter of: Mitsubishi Electric & Electronics USA...

An Analysis of Counterinsurgency in Iraq: Mosul, Ramadi, and Samarra from 2003-2005

DTIC Science & Technology

2006-12-01

Information Operations as Part of COIN Warfare”, School of Advanced Military Studies, May 2005. Mounir Elkhamri, Lester W. Grau, Laurie King-Irani, Amanda S...Lieutenant Colonel, USA, July, 22, 2006 Lovelace , Daniel, Captain, USA, August 6, 2006. Mathews, Tim, Captain, USA, August 11, 2006. McLamb, Joseph

Training Detractors in FORSCOM Divisions and How They Are Handled

DTIC Science & Technology

1980-05-01

mandatory training on conducting effective combat training, and explored four resource areas No. DD JAN 1473 EDITION OF I NOV 65 IS OBSOLETE...INSTITUTIONAL RSCH I USA AIR DEFENSE SCHOOL AITN: AISA -CD-MS 1 USAA|)S-LIBRARY-DOCUMENIS I USA AIR DEFENSE BOAR) ATIN: FILES REPOSITORY I USA sERGEANTS

76 FR 51349 - Foreign-Trade Zone 72-Indianapolis, IN; Application for Manufacturing Authority, Brevini Wind USA...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

...--Indianapolis, IN; Application for Manufacturing Authority, Brevini Wind USA, Inc., (Wind Turbine Gear Boxes... Airport Authority, grantee of FTZ 72, requesting manufacturing authority on behalf of Brevini Wind USA, Inc. (Brevini), to manufacture wind turbine gear boxes under FTZ procedures within FTZ 72. The...

Comparative Review of UK-USA Industry-University Relationships

ERIC Educational Resources Information Center

Decter, Moira H.

2009-01-01

Purpose: The purpose of this paper is to explore significant historical changes, legislation and policy in the UK and USA from the 1960s to present day relating to university-industry relationships. Design/methodology/approach: The paper presents a review of papers, reports and policy documents from the UK and USA drawing comparisons of…

Physicochemical and sensory analysis of USA rice varieties developed for the basmati and jasmine markets

USDA-ARS?s Scientific Manuscript database

There is a steady demand for imported basmati and jasmine rice in The USA. Rice varieties that can be domestically produced and compete with these imports, have been developed from basmati, jasmine, and other aromatic germplasm sources. This study evaluated differences among eight USA aromatic varie...

DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE

EPA Science Inventory

DISPOSITION OF BROMODICHLOROMETHANE IN HUMANS FOLLOWING ORAL AND DERMAL EXPOSURE. TL Leavens1, MW Case1, RA Pegram1, BC Blount2, DM DeMarini1, MC Madden1, and JL Valentine3. 1NHEERL, USEPA, RTP, NC, USA; 2CDC, Atlanta, GA, USA; 3RTI, RTP, NC, USA.
The disinfection byproduct ...

76 FR 80913 - Carib Energy (USA) LLC; Application for Long-Term Authorization To Export Domestically Produced...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... DEPARTMENT OF ENERGY [FE Docket No. 11-141-LNG] Carib Energy (USA) LLC; Application for Long-Term... by Carib Energy (USA) LLC (Carib), requesting long- term, multi-contract authorization to export up.... SUPPLEMENTARY INFORMATION: Background Carib is a Delaware limited liability company with its principal place of...

Why Does the USA Dominate University League Tables?

ERIC Educational Resources Information Center

Li, Mei; Shankar, Sriram; Tang, Kam Ki

2011-01-01

According to the Academic Ranking of World Universities, the world's top 500 universities are located in only 38 countries, with the USA alone having 157 of them. This article investigates the socioeconomic determinants of the wide performance gap between countries, and whether the USA's dominance is largely due to its economic power. A large…

USA Science and Engineering Festival 2014

NASA Image and Video Library

2014-04-25

A NASA staff member shows attendees of the USA Science and Engineering Festival what happens to the human body in space without a space suit using a marshmallow bunny. The USA Science and Engineering Festival took place at the Washington Convention Center in Washington, DC on April 26 and 27, 2014. Photo Credit: (NASA/Aubrey Gemignani)

76 FR 43684 - Verde Energy USA Trading, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4041-000] Verde Energy USA Trading, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Verde Energy USA Trading, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 38280 - Verde Energy USA New York, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2071-000] Verde Energy USA New York, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Verde Energy USA New York, LLC's application for market-based rate authority, with an accompanying rate...

FY2015 Analysis of the Teamwork USA Program. Memorandum

ERIC Educational Resources Information Center

Howard, Mark

2015-01-01

The Department of Research and Evaluation (DRE) has completed an analysis of the performance of students who participated in the Teamwork USA Program, administered in FY2014 at three District schools. Teamwork USA hopes to improve student achievement at select Title I elementary schools via its Instrumental Music Program grant. This memorandum to…

76 FR 20806 - Aviation Proceedings, Agreements Filed the Week Ending March 19, 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... North & Central Pacific (except between USA and Korea (Rep. of), Malaysia) Minutes (Memo 518). (b) TC31 North and Central Pacific (except between Korea (Rep. of), Malaysia and USA) Mail Vote 667--Resolution.... Subject: (a) TC31 North & Central Pacific Between Korea (Rep. of), Malaysia and USA Flex Fares Resolutions...

75 FR 9592 - National Grid USA; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AC10-50-000; RM08-5-000] National Grid USA; Notice of Filing February 24, 2010. Take notice that on February 10, 2010, National Grid USA submitted a request for waiver of certain FERC Form No. 1 reporting requirements under Part 141 of...

75 FR 11937 - Ternium USA, Inc.; Shreveport, LA; Notice of Termination of Investigation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-12

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,438] Ternium USA, Inc.; Shreveport, LA; Notice of Termination of Investigation Pursuant to Section 223 of the Trade Act of 1974, as... company official on behalf of workers of Ternium, USA, Inc., Shreveport, Louisiana. The petitioner has...

77 FR 28568 - Foreign-Trade Zone 45-Portland, OR; Application for Subzone, Shimadzu USA Manufacturing, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [S-52-2012] Foreign-Trade Zone 45--Portland, OR; Application for Subzone, Shimadzu USA Manufacturing, Inc., Canby, OR An application has been submitted to the...-purpose subzone status for the facility of Shimadzu USA Manufacturing, Inc. (SUM), located in Canby...

77 FR 48127 - Approval of Subzone Status; Shimadzu USA Manufacturing, Inc., Canby, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [S-52-2012] Approval of Subzone Status; Shimadzu USA Manufacturing, Inc., Canby, OR On May 8, 2012, the Executive Secretary of the Foreign-Trade Zones... subzone status subject to the existing activation limit of FTZ 45, on behalf of Shimadzu USA Manufacturing...

ORGANIC POLLUTANT DEPOSITION TO THE SIERRA NEVADA (CALIFORNIA, USA) SNOWPACK AND ASSOCIATED LAKE AND STREAM ECOSYSTEM

EPA Science Inventory

High elevation ecosystems in the western USA and Canada are receiving deposition of persistent organic pollutants (POPs) that presumably originate in the USA as well as outside its borders. In April 1992 we obtained paired snowpack samples from each of two watersheds located in t...

78 FR 70033 - Encana Marketing (USA) Inc. v. Rockies Express Pipeline LLC; Notice of Complaint

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... Marketing (USA) Inc. v. Rockies Express Pipeline LLC; Notice of Complaint Take notice that on November 15... Commission (Commission), 18 CFR 385.206, Encana Marketing (USA) Inc. (Encana Marketing or Complainant), filed... Rockies Express has unlawfully denied Encana Marketing's request to make changes to the primary delivery...

75 FR 8920 - Grant of Authority for Subzone Status; Danisco USA, Inc., Sweeteners Division (Xylitol, Xylose...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... Status; Danisco USA, Inc., Sweeteners Division (Xylitol, Xylose, Galactose and Mannose); Thomson, IL...., Sweeteners Division, located in Thomson, Illinois, (FTZ Docket 4-2009, filed 2/4/2009); Whereas, notice... xylitol, xylose, galactose and mannose at the facility of Danisco USA, Inc., Sweeteners Division, located...

75 FR 13141 - Powertech (USA), Inc.; Establishment of Atomic Safety and Licensing Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... following proceeding: Powertech (USA) Inc. (Dewey-Burdock In Situ Uranium Recovery Facility). This Board is... Powertech (USA) Inc.'s application for a source materials license for an in situ uranium recovery facility... Commission dated December 29, 1972, published in the Federal Register, 37 FR 28,710 (1972), and the...

75 FR 22411 - Fonterra (USA) Inc.; Filing of Food Additive Petition

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

...] Fonterra (USA) Inc.; Filing of Food Additive Petition AGENCY: Food and Drug Administration, HHS. ACTION... a petition proposing that the food additive regulations be amended to provide for the safe use of... that a food additive petition (FAP 0A4781) has been filed by Fonterra (USA), Inc., c/o Burdock Group...

The Longitudinal Properties of a Solar Energetic Particle Event Investigated Using Modern Solar Imaging

DTIC Science & Technology

2012-06-10

and white light) and the longitudinal extent of the SEP event in the heliosphere. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION...The STEREO SECCHI data are pro- duced by a consortium of RAL (UK), NRL (USA), LMSAL (USA), GSFC (USA), MPS (Germany), CSL (Belgium), IOTA (France

75 FR 74711 - Planet Energy (USA) Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2166-000] Planet Energy (USA) Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding, of Planet Energy (USA) Corp.'s application for market-based rate authority, with an accompanying...

Integration of GCAM-USA into GLIMPSE: Update and ...

EPA Pesticide Factsheets

The purpose of this presentation is to (i) discuss changes made to the GCAM-USA model to more fully support long-term, coordinated environmental-climate-energy planning within the U.S., and (ii) demonstrate the graphical user interface that has been constructed to construct modeling scenarios, execute GCAM-USA, and visualize and compare model outputs. GLIMPSE is intended to provide insights into linkages and synergies among the goals of air quality management, climate change mitigation, and long-range energy planning. We have expanded GLIMPSE to also incorporate the open-source Global Change Assessment Model-USA (GCAM-USA), which has state-level representation of the U.S. energy system. With GCAM-USA, GLIMPSE can consider more aspects of the economy, linkages to the water and climate systems, and interactions with other regions of the world. A user-friendly graphical interface allows the system to be applied by analysts to explore a range of policies, such emission taxes or caps, efficiency standards, and renewable portfolio standards. We expect GLIMPSE to be used within research and planning activities, both within the EPA and beyond.

USA National Phenology Network observational data documentation

USGS Publications Warehouse

Rosemartin, Alyssa H.; Denny, Ellen G.; Gerst, Katharine L.; Marsh, R. Lee; Posthumus, Erin E.; Crimmins, Theresa M.; Weltzin, Jake F.

2018-04-25

The goals of the USA National Phenology Network (USA-NPN, www.usanpn.org) are to advance science, inform decisions, and communicate and connect with the public regarding phenology and species’ responses to environmental variation and climate change. The USA-NPN seeks to advance the science of phenology and facilitate ecosystem stewardship by providing phenological information freely and openly. To accomplish these goals, the USA-NPN National Coordinating Office (NCO) delivers observational data on plant and animal phenology in several formats, including minimally processed status and intensity datasets and derived phenometrics for individual plants, sites, and regions. This document describes the suite of observational data products delivered by the USA National Phenology Network, covering the period 2009–present for the United States and accessible via the Phenology Observation Portal (http://dx.doi.org/10.5066/F78S4N1V) and via an Application Programming Interface. The data described here have been used in diverse research and management applications, including over 30 publications in fields such as remote sensing, plant evolution, and resource management.

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

NASA Image and Video Library

2003-12-19

KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.