AN OVERVIEW PRESENTATION OF USEPA AND USDA DRINKING WATER TREATMENT SYSTEM DEMONSTRATIONS IN CHINA

EPA Science Inventory

Under an interagency agreement with the US Department of Agriculture, US EPA is coordinating support for several water treatment research demonstrations in China. EPA has installed two small drinking water treatment technologies (a bottled water system for a small community and ...

AN OVERVIEW PAPER OF USEPA AND USDA DRINKING WATER TREATMENT SYSTEM DEMONSTRATIONS IN CHINA

EPA Science Inventory

Under an interagency agreement with the US Department of Agriculture, US EPA is coordinating support for several water treatment research demonstrations in China. EPA has installed two small drinking water treatment technologies (a bottled water system for a small community and ...

USDA-ARS and US EPA scientific investigations concerning biochars impact on soil health characteristics, microbial transport, and environmental restoration of mine-impacted soils

EPA Science Inventory

Biochar is being evaluated by scientists from the United States Department of Agriculture (USDA) Agricultural Research Service (ARS) for its potential to sequester soil C, to improve soil health, and to increase crop yields. ARS scientists from multiple locations (Florence SC, K...

Termiticide testing in full swing USDA-FS's Mississippi site hit hard by hurricane katrina

Treesearch

Terry Wagner; Joe Mulrooney; Thomas Shelton

2006-01-01

The USDA-FS wrote and administered 44 termiticide testing agreements with industry; Hurricane Katrina hit hard the oldest U.S. Forest Service test sitel and the Termiticide Standards Committee of the Association of Structural PEst Control Regulatory Officials proposed a revision of the EPA's Product Performance Test Guideline, OPPTS 810.3600.

EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and ...

EPA Pesticide Factsheets

EPA is releasing for external peer review and public comment an important draft document reviewing the literature on the health effects of dioxin and related compounds (also referred to as 2,3,7,8-Tetrachlorodibenzo-p-dioxin). At the request of Administrator Jackson, EPA is in the process of re-assessing the science on the effects of dioxin, a toxic chemical that is emitted by multiple sources, on the public’s health. This draft dioxin report is EPA’s response to key comments and recommendations made by the National Academy of Sciences on the Agency’s draft dioxin reassessment. This assessment has been in progress for many years and raises health issues of broad interest to scientists and policymakers across the federal family. The Agency’s draft report includes significant new analyses on potential cancer and non-cancer human health effects that may result from exposures to dioxins and includes an oral reference dose for what is considered to be the most toxic of the dioxin-like compounds. EPA’s Science

76 FR 71880 - Protections for Subjects in Human Research Involving Pesticides; Notification of Submission to...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-21

... of Agriculture AGENCY: Environmental Protection Agency (EPA). ACTION: Notification of submission to the Secretary of Agriculture. SUMMARY: This document notifies the public that the Administrator of EPA has forwarded to the Secretary of the United States Department of Agriculture (USDA) a draft final...

Final work plan : Phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Savannah, Missouri.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

From approximately 1949 until 1970, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility on federally owned property approximately 0.25 mi northwest of Savannah, Missouri. During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities. In November 1998, carbon tetrachloride was detected in a private well (Morgan) roughly 50 ft south of the former CCC/USDA facility, as a result of state-wide screening of private wells near former CCC/USDA facilities, conducted in Missouri by the U.S. Environmentalmore » Protection Agency (EPA 1999). The 1998 and subsequent investigations by the EPA and the Missouri Department of Natural Resources (MoDNR) confirmed the presence of carbon tetrachloride in the Morgan well, as well as in a second well (on property currently occupied by the Missouri Department of Transportation [MoDOT]), approximately 400 ft east of the former CCC/USDA facility. Carbon tetrachloride concentrations in the Morgan well have ranged from the initial value of 29 {micro}g/L in 1998, up to a maximum of 61 {micro}g/L in 1999, and back down to 22 {micro}g/L in 2005. The carbon tetrachloride concentration in the MoDOT well in 2000 (the only time it was sampled) was 321 {micro}g/L. The concentrations for the two wells are above the EPA maximum contaminant level (MCL) of 5 {micro}g/L for carbon tetrachloride (EPA 1999; MoDNR 2000a,b). Because the observed contamination in the Morgan and MoDOT wells might be linked to the past use of carbon tetrachloride-based grain fumigants at its former grain storage facility, the CCC/USDA will conduct investigations to (1) characterize the source(s), extent, and factors controlling the subsurface distribution and movement of carbon tetrachloride at Savannah and (2) evaluate the health and environmental threats potentially posed by the contamination. This work will be performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The investigative activities at Savannah will be conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by UChicago Argonne, LLC, for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an agreement with the DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. The site characterization at Savannah will take place in phases. This approach is recommended by the CCC/USDA and Argonne, so that information obtained and interpretations developed during each incremental stage of the investigation can be used most effectively to guide subsequent phases of the program. This site-specific Work Plan outlines the specific technical objectives and scope of work proposed for Phase I of the Savannah investigation. This Work Plan also includes the community relations plan to be followed throughout the CCC/USDA program at the Savannah site. Argonne is developing a Master Work Plan specific to operations in the state of Missouri. In the meantime, Argonne will issue a Provisional Master Work Plan (PMWP; Argonne 2007) that will be submitted to the MoDNR for review and approval. The agency has already reviewed and approved (with minor changes) the present Master Work Plan (Argonne 2002) under which Argonne currently operates in Kansas. The PMWP (Argonne 2007) will provide detailed information and guidance on the investigative technologies, analytical methodologies, quality assurance-quality control measures, and general health and safety policies to be employed by Argonne for all investigations at former CCC/USDA grain storage facilities in Missouri. Both the PMWP and this site-specific Work Plan must therefore be consulted for a complete description of the planned Phase I work at the former CCC/USDA facility at Savannah.« less

Final report : phase I investigation at the former CCC/USDA grain storage facility in Savannah, Missouri.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

From approximately 1949 until 1970, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility on federally owned property approximately 0.25 mi northwest of Savannah, Missouri (Figure 1.1). During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities. In November 1998, carbon tetrachloride was detected in a private well (Morgan) roughly 50 ft south of the former CCC/USDA facility, as a result of state-wide screening of private wells near former CCC/USDA facilities, conducted in Missouri by themore » U.S. Environmental Protection Agency (EPA 1999). The 1998 and subsequent investigations by the EPA and the Missouri Department of Natural Resources (MoDNR) confirmed the presence of carbon tetrachloride in the Morgan well, as well as in a second well (on property currently owned and occupied by the Missouri Department of Transportation [MoDOT]), described as being approximately 400 ft east of the former CCC/USDA facility. The identified concentrations in these two wells were above the EPA maximum contaminant level (MCL) and the default target level (DTL) values of 5.0 {micro}g/L for carbon tetrachloride in water used for domestic purposes (EPA 1999; MoDNR 2000a,b, 2006). (The DTL is defined in Section 4.) Because the observed contamination in the Morgan and MoDOT wells might be linked to the past use of carbon tetrachloride-based fumigants at its former grain storage facility, the CCC/USDA is conducting an investigation to (1) characterize the source(s), extent, and factors controlling the subsurface distribution and movement of carbon tetrachloride at Savannah and (2) evaluate the potential risks to human health, public welfare, and the environment posed by the contamination. This work is being performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and the MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The site characterization at Savannah is being conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. A phased approach is being employed by the CCC/USDA and Argonne, with the approval of the MoDNR, so that information obtained and interpretations developed during each incremental stage of the study can be used most effectively to guide subsequent aspects of the program. This report presents the technical findings of Phase I of Argonne's studies. The Phase I investigation was undertaken in accord with the final site-specific Phase I Work Plan for Savannah (Argonne 2007), as well as with the Master Work Plan (MWPK) for CCC/USDAArgonne operations in the state of Kansas (Argonne 2002), which the MoDNR reviewed and approved (with minor revisions) for temporary use in Missouri to facilitate the start-up of the CCC/USDA's activities at Savannah. (Argonne is developing a similar Master Work Plan for operations in Missouri that is based on the existing MWPK, with the approval of the MoDNR. The Missouri document has not been finalized, however, at this time.) The site-specific Savannah Work Plan (Argonne 2007; approved by the MoDNR [2007a]) (1) summarized the pre-existing knowledge base for the Savannah investigation site compiled by Argonne and (2) described the site-specific technical objectives and the intended scope of work developed for this phase of the investigation. Four primary technical objectives were identified for the Phase I studies, as follows: (1) Update the previous (MoDNR 2000a,b) inventory and status of private wells in the immediate vicinity of the former CCC/USDA grain storage facility, and sample the identified wells for analyses for volatile organic compounds (VOCs) and geochemical constituents. (2) Investigate for possible evidence of a soil source of carbon tetrachloride contamination to groundwater beneath the former CCC/USDA facility. (3) Obtain preliminary information on the site-specific lithologies and hydrostratigraphy at the former CCC/USDA grain storage location. (4) Establish preliminary groundwater monitoring points, to investigate the patterns of groundwater movement affecting possible contaminant migration near the former CCC/USDA facility.« less

EPA's Science Plan for Activities Related to Dioxins in the ...

EPA Pesticide Factsheets

The U.S. Environmental Protection Agency is currently addressing several issues related to dioxins and dioxin-like chemicals in the environment. These include the comprehensive human health and exposure assessment for dioxin, commonly called the dioxin reassessment and a review of dioxin soil clean-up levels currently in use across the United States. To move forward with both of these efforts, as well as other dioxin related activities, a plan with interim milestones has been developed and it is outlined below. EPA’sExposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD) and Related Compounds; Response to NAS and Completion of Dioxin Reassessment 1. EPA will release a draft report that responds to the recommendations and comments included in the National Academy of Sciences’ (NAS) 2006 review of EPA’s 2003 draft dioxin reassessment. UPDATED May 21, 2010: The draft response to comments report titled EPA’s Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments (External Review Draft) (“Draft Dioxin Reanalysis”) was completed and released for public review and comment on May 21, 2010. EPA’s National Center for Environment Assessment (NCEA) in the Office of Research and Development, will prepare a limited response to key comments and recommendations in the NAS report (draft response to comments report). The draft response will focus on dose-response

IRIS Toxicological Review of Vanadium Pentoxide ...

EPA Pesticide Factsheets

On September 30, 2011, the draft Toxicological Review of Vanadium Pentoxide and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process (May 2009), introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the IRIS Toxicological Review of Vanadium Pentoxide and the charge to external peer reviewers are posted on this site. EPA is reassessing its IRIS toxicological review of vanadium pentoxide (CASRN 1314-62-1). This vanadium pentoxide reassessment consists of an oral reference dose (RfD), an inhalation reference concentration (RfC), an inhalation unit risk (IUR) and a cancer weight of evidence descriptor. This is the first assessment developing an RfC or IUR for this compound. This assessment is intended to provide human health data to support agency regulatory decisions.

77 FR 33213 - An Assessment of Potential Mining Impacts on Salmon Ecosystems of Bristol Bay, Alaska-Peer Review...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... Water, and EPA's Office of Research and Development. The U.S. EPA conducted this assessment to determine... with its role under the Clean Water Act. The assessment is intended to provide a scientific and... fisheries biology and wildlife ecology. Dr. Gordon Reeves, USDA Pacific NW Research Station--Expertise in...

Memorandum About the Science and Ethics Review of USDA Protocol for Laboratory Evaluation of Bite Protection from Repellent-treated Clothing for the United States Military

EPA Pesticide Factsheets

This review assesses the scientific aspects of the proposed research for a special efficacy study to assess etofenprox-treated U.S. Military uniforms in terms of the recommendations of the EPA and of the EPA Human Studies Review Board.

NREL Biomethane GIS Data

DOE Data Explorer

Milbrandt, Anelia

2016-06-15

This dataset contains information about the biomass resources generated by county in the United States. It includes the following feedstock categories: crop residues, forest residues, primary mill residues, secondary mill residues, and urban wood waste. The estimates are based on county-level statistics and/or point-source data gathered from the U.S. Department of Agriculture (USDA), USDA Forest Service, EPA and other organizations, which are further processed using relevant assumptions and conversions.

Final Report from the External Peer Review of the IRIS ...

EPA Pesticide Factsheets

This document is the final report for the 2004 external peer review for the EPA IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene, prepared by the Office of Research and Development's National Center for Environmental Assessment (NCEA), for the Integrated Risk Information System (IRIS) Database. A panel of external peer reviewers met to discuss the IRIS report and their responses to the charge questions on July 30, 2004. This document contains the final written comments of the external peer reviewers. This document is the final report for the 2004 external peer review for the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene, prepared by the U.S. Environmental Protection Agency (EPA), National Center for Environmental Assessment (NCEA), for the Integrated Risk Information System (IRIS). A panel of external peer reviewers met to discuss their responses to the charge questions on July 30, 2004. This document contains the final written comments of the external peer reviewers.

Supporting Sustainable Rural Communities

EPA Pesticide Factsheets

Supporting Sustainable Rural Communities summarizes the findings of a work group of EPA, HUD, DOT, and USDA and creates a framework for the Partnership for Sustainable Communities’ future work with rural communities.

78 FR 68741 - Tebuconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

... States Department of Agriculture (USDA) 2003-2008 National Health and Nutrition Examination Survey, What... Department of Agriculture/National Agricultural Statistics Service (USDA/NASS), proprietary market surveys... each existing use is derived by combining available public and private market survey data for that use...

7 CFR 634.40 - Financial management.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., DEPARTMENT OF AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM Financial Management § 634.40... comprehensive USDA/EPA joint water quality monitoring, evaluating, and analysis will be funded according to the...

75 FR 29969 - Environmental Impact Statement; Determination of Nonregulated Status of Sugar Beet Genetically...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... Tolerance to the Herbicide Glyphosate AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION... genetically engineered for tolerance to the herbicide glyphosate. The petition stated that this article should...-tolerant sugar beet systems. What are the impacts of weeds, herbicide-tolerant weeds, weed management...

Modernizing the Regulatory System for Biotechnology Products

EPA Pesticide Factsheets

This Web page describes the continuing effort to modernize the federal regulatory system for biotechnology products as well as clarify various roles of EPA, FDA and USDA in evaluating new biotechnology products.

Clean Water Act Section 404 and Agriculture

EPA Pesticide Factsheets

The U.S. Department of Agriculture (USDA) and EPA have longstanding programs to promote water quality and broader environmental goals identified in both the Agriculture Act of 2014 and the Clean Water Act.

About Codex

EPA Pesticide Factsheets

The Codex Committee on Pesticide Residues (CCPR) is responsible for establishing Codex MRLs for pesticide residues in specific food items or in groups of food. EPA and an alternate delegate from USDA represent the United States on this committee.

Collaboration in Action: Office of Research and Development ...

EPA Pesticide Factsheets

The "Collaboration in Action: US EPA's Office of Research and Develop - Current Wildfire Research Program" was invited by the USDA's US Forest Service's Scientific Executive Committee to provide USFS scientific leadership active and potential future opportunities for cooperation/collaboration. Health impacts of wildfire smoke merit the attention and action of the US EPA and current research is supported in the ACE and SHC Research Programs. Wildland fire smoke research has taken on greater importance because the 1) contribution of wildland fire PM emissions relative to total US PM emissions is increasing, 2) the population health impacts are measurable and costly, 3) vulnerable and sensitive populations at-risk are increasing attendant to our aging U.S. population and the increasing area of the wildland-urban interface, and 4) health impacts of smoke could be minimized by identifying at-risk individuals and reducing their exposures. Examples are provided. The "Collaboration in Action: US EPA's Office of Research and Develop - Current Wildfire Research Program" was invited by the USDA's US Forest Service's Scientific Executive Committee to provide USFS scientific leadership active and potential future opportunities for cooperation/collaboration.

Plant Distribution Data Show Broader Climatic Limits than Expert-Based Climatic Tolerance Estimates

PubMed Central

Curtis, Caroline A.; Bradley, Bethany A.

2016-01-01

Background Although increasingly sophisticated environmental measures are being applied to species distributions models, the focus remains on using climatic data to provide estimates of habitat suitability. Climatic tolerance estimates based on expert knowledge are available for a wide range of plants via the USDA PLANTS database. We aim to test how climatic tolerance inferred from plant distribution records relates to tolerance estimated by experts. Further, we use this information to identify circumstances when species distributions are more likely to approximate climatic tolerance. Methods We compiled expert knowledge estimates of minimum and maximum precipitation and minimum temperature tolerance for over 1800 conservation plant species from the ‘plant characteristics’ information in the USDA PLANTS database. We derived climatic tolerance from distribution data downloaded from the Global Biodiversity and Information Facility (GBIF) and corresponding climate from WorldClim. We compared expert-derived climatic tolerance to empirical estimates to find the difference between their inferred climate niches (ΔCN), and tested whether ΔCN was influenced by growth form or range size. Results Climate niches calculated from distribution data were significantly broader than expert-based tolerance estimates (Mann-Whitney p values << 0.001). The average plant could tolerate 24 mm lower minimum precipitation, 14 mm higher maximum precipitation, and 7° C lower minimum temperatures based on distribution data relative to expert-based tolerance estimates. Species with larger ranges had greater ΔCN for minimum precipitation and minimum temperature. For maximum precipitation and minimum temperature, forbs and grasses tended to have larger ΔCN while grasses and trees had larger ΔCN for minimum precipitation. Conclusion Our results show that distribution data are consistently broader than USDA PLANTS experts’ knowledge and likely provide more robust estimates of climatic tolerance, especially for widespread forbs and grasses. These findings suggest that widely available expert-based climatic tolerance estimates underrepresent species’ fundamental niche and likely fail to capture the realized niche. PMID:27870859

EPA/USDA Water Quality Trading Partnership Agreement

EPA Pesticide Factsheets

The document details an agreement between the U. S. Department of Agriculture, Natural Resources Conservation Service (NRCS) and the U. S. Environmental Protection Agency on collaboration efforts to establish viable water quality credit trading markets.

7 CFR 2902.19 - Composite panels.

Code of Federal Regulations, 2011 CFR

2011-01-01

...; and Signage. USDA is requesting that manufacturers of these qualifying biobased products provide... EPA-designated laminated paperboard, structural fiberboard, shower and restroom dividers, and signage... laminated paperboard and structural fiberboard, shower and restroom dividers, and signage containing...

7 CFR 2902.19 - Composite panels.

Code of Federal Regulations, 2010 CFR

2010-01-01

...; and Signage. USDA is requesting that manufacturers of these qualifying biobased products provide... EPA-designated laminated paperboard, structural fiberboard, shower and restroom dividers, and signage... laminated paperboard and structural fiberboard, shower and restroom dividers, and signage containing...

Notification: Evaluation of EPA's Management of Resistance Issues Related to Herbicide Tolerant Genetically Engineered Crops

EPA Pesticide Factsheets

Project #OPE-FY16-0023, March 25, 2016. The EPA OIG plans to begin preliminary research to assess the EPA's management and oversight of resistance issues related to herbicide tolerant genetically engineered crops.

SIMULTANEOUS DETERMINATION OF PCDD/PCDF AND DIOXIN-LIKE PCBS IN EDIBLE VEGETABLE OILS

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) reassessment of the toxicity of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDF) and dioxin-like polychlorinated biphenyls (PCB) identifies ingestion as a key route of human exposure to these compounds. The reassessme...

CONSOLIDATED COMMENTS ON THE DRAFT DIOXIN REASSESSMENT, JULY 2000

EPA Science Inventory

This report was prepared by Eastern Research Group, Inc. (ERG), an EPA contractor, as a general record of discussion for the peer review meeting. This report captures the main points of scheduled presentations and highlights discussions among the reviewers. This report does not c...

78 FR 36677 - Triforine, Pesticide Tolerances; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

..., Pesticide Tolerances; Technical Correction AGENCY: Environmental Protection Agency (EPA). ACTION: Correcting.... What does this technical correction do? EPA is correcting the CFR section number assigned to the... opportunity for public comment. EPA has determined that there is good cause for making this technical...

Stakeholder Conference on Bee Health

EPA Pesticide Factsheets

USDA and EPA released a comprehensive scientific report on honey bee health in May 2013. The report points to multiple factors playing a role in honey bee colony declines, including parasites and disease, genetics, poor nutrition, and pesticide exposure.

Colony Collapse Disorder

EPA Pesticide Factsheets

In CCD, the majority of worker bees in a colony disappear and leave behind a queen, plenty of food and a few nurse bees to care for remaining immature bees and the queen. EPA and USDA are working to understand this problem.

77 FR 41356 - Monsanto Co.; Availability of Petition for Determination of Nonregulated Status of Soybean...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... Engineered for Herbicide Tolerance AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice... soybean designated as MON 87708, which has been genetically engineered for tolerance to the herbicide... MON 87708, which has been genetically engineered for tolerance to the herbicide dicamba, stating that...

77 FR 41353 - GENECTIVE SA; Availability of Petition for Determination of Nonregulated Status of Maize...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... Engineered for Herbicide Tolerance AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice... VCO-[Oslash]1981-5, which has been genetically engineered for tolerance to the herbicide glyphosate...- [Oslash]1981-5, which has been genetically engineered for tolerance to the herbicide glyphosate, stating...

REASSESSMENT OF CYANOTOXIN MIXTURES IN THE 2007 USEPA NATIONAL LAKES ASSESSMENT

EPA Science Inventory

Microcystins have been the most frequently reported class of cyanotoxins historically. In the 2007 US EPA National Lake Assessment (2007 NLA), the USGS found that microcystins were detected in integrated photic zone samples of approximately 30% of sampled lakes (n= 1028). Based o...

78 FR 32574 - Azoxystrobin; Pesticide Tolerance; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-31

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2012-0283; FRL-9387-4] Azoxystrobin..., establishing new and modifying existing tolerances for residues of azoxystrobin. EPA inadvertently omitted the... for residues of the fungicide azoxystrobin in or on various commodities. EPA inadvertently omitted the...

76 FR 40811 - Maneb; Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

...; Tolerance Actions AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is... established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0327. All... . SUPPLEMENTARY INFORMATION: I. General Information A. Does this action apply to me? You may be potentially...

Sustaining the future of plant breeding: The critical role of the USDA-ARS National Plant Germplasm System

USDA-ARS?s Scientific Manuscript database

Plant breeders require genetic diversity in their breeding programs to develop cultivars that are productive, nutritious, tolerant of biotic and abiotic stresses, and make efficient use of water and fertilizer. The USDA-ARS National Plant Germplasm System (NPGS) is a major source for global plant ge...

United States 2030 Food Loss and Waste Reduction Goal

EPA Pesticide Factsheets

On September 16, 2015, the United States Department of Agriculture (USDA) and the United States Environmental Protection Agency (EPA) announced the first ever domestic goal to reduce food loss and waste by half by the year 2030.

Labeling of Pesticide Products under the National Organic Program

EPA Pesticide Factsheets

This notice describes how registrants can obtain EPA approval of label language indicating that all ingredients in a pesticide product and all uses of that pesticide meet the criteria defined in the USDA National Organic Program Rule.

EVALUATION OF WATER MONITORING INSTRUMENTATION AT EPA'S WATER AWARENESS TECHNOLOGY EVALUATION RESEARCH SECURITY CENTER

EPA Science Inventory

The safety and security of distribution systems has come under reassessment in the past year. Several chemical and biological agents have been identified that might constitute a credible threat against water supply systems. There have also been a few reported threats against wate...

Assessment of five cold chilling tolerance traits and GWAS mapping in rice using the USDA mini-core collection

USDA-ARS?s Scientific Manuscript database

Rice (Oryza sativa L.) is often exposed to cool or cold temperatures during spring planting in a temperate climate. A better understanding of the genetic pathways regulating this chilling tolerance will enable breeders to develop varieties with improved tolerance during the germination and young see...

EPA and USDA to Help Two Maine Communities with Economic Development Goals

EPA Pesticide Factsheets

The U.S. Environmental Protection Agency and the U.S. Department of Agriculture have selected Eastport & Millinocket, Maine, as partners in Cool & Connected, an innovative initiative that helps small towns use broadband service for economic development.

78 FR 14487 - Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

...] Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY: This regulation proposes the extension of the time-limited... related to EPA's extension of the time-limited interim tolerances for the combined residues of the...

78 FR 15880 - Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-13

... Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation extends the time-limited interim tolerances for the... . II. Background A detailed summary of the background related to EPA's extension of the time-limited...

NASA Data for Water Resources Applications

NASA Technical Reports Server (NTRS)

Toll, David; Houser, Paul; Arsenault, Kristi; Entin, Jared

2004-01-01

Water Management Applications is one of twelve elements in the Earth Science Enterprise National Applications Program. NASA Goddard Space Flight Center is supporting the Applications Program through partnering with other organizations to use NASA project results, such as from satellite instruments and Earth system models to enhance the organizations critical needs. The focus thus far has been: 1) estimating water storage including snowpack and soil moisture, 2) modeling and predicting water fluxes such as evapotranspiration (ET), precipitation and river runoff, and 3) remote sensing of water quality, including both point source (e.g., turbidity and productivity) and non-point source (e.g., land cover conversion such as forest to agriculture yielding higher nutrient runoff). The objectives of the partnering cover three steps of: 1) Evaluation, 2) Verification and Validation, and 3) Benchmark Report. We are working with the U.S. federal agencies including the Environmental Protection Agency (EPA), the Bureau of Reclamation (USBR) and the Department of Agriculture (USDA). We are using several of their Decision Support Systems (DSS) tools. This includes the DSS support tools BASINS used by EPA, Riverware and AWARDS ET ToolBox by USBR and SWAT by USDA and EPA. Regional application sites using NASA data across the US. are currently being eliminated for the DSS tools. The current NASA data emphasized thus far are from the Land Data Assimilation Systems WAS) and MODIS satellite products. We are currently in the first two steps of evaluation and verification validation. Water Management Applications is one of twelve elements in the Earth Science Enterprise s National Applications Program. NASA Goddard Space Flight Center is supporting the Applications Program through partnering with other organizations to use NASA project results, such as from satellite instruments and Earth system models to enhance the organizations critical needs. The focus thus far has been: 1) estimating water storage including snowpack and soil moisture, 2) modeling and predicting water fluxes such as evapotranspiration (ET), precipitation and river runoff, and 3) remote sensing of water quality, including both point source (e.g., turbidity and productivity) and non-point source (e.g., land cover conversion such as forest to agriculture yielding higher nutrient runoff). The objectives of the partnering cover three steps of 1) Evaluation, 2) Verification and Validation, and 3) Benchmark Report. We are working with the U.S. federal agencies the Environmental Protection Agency (EPA), the Bureau of Reclamation (USBR) and the Department of Agriculture (USDA). We are using several of their Decision Support Systems (DSS) tools. T us includes the DSS support tools BASINS used by EPA, Riverware and AWARDS ET ToolBox by USBR and SWAT by USDA and EPA. Regional application sites using NASA data across the US. are currently being evaluated for the DSS tools. The current NASA data emphasized thus far are from the Land Data Assimilation Systems (LDAS) and MODIS satellite products. We are currently in the first two steps of evaluation and verification and validation.

Summary of operations and performance of the Murdock site restoration project in June 2005-December 2006.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

This document summarizes the performance of the groundwater and surface water restoration systems installed by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) at the former CCC/USDA grain storage facility in Murdock, Nebraska, during the initial period of systems operation, from June 2005 through December 2006. In the Murdock project, several innovative technologies are being used to remove carbon tetrachloride contamination from a shallow aquifer underlying the town, as well as from water naturally discharged to the surface at the headwaters of a small creek (a tributary to Pawnee Creek) north of the town (Figure 1.1). Themore » restoration activities at Murdock are being conducted by the CCC/USDA as a non-time-critical removal action under the regulatory authority and supervision of the U.S. Environmental Protection Agency (EPA), Region VII. Argonne National Laboratory assisted the CCC/USDA by providing technical oversight for the restoration effort and facilities during this review period. Included in this report are the results of all sampling and monitoring activities performed in accord with the EPA-approved Monitoring Plan for this site (Argonne 2006), as well as additional investigative activities conducted during the review period. This document presents overviews of the treatment facilities (Section 2) and site operations and activities (Section 3), then describes the groundwater, surface water, vegetation, and atmospheric monitoring results (Section 4) and modifications and costs during the review period (Section 5). Section 6 summarizes the initial period of operation.« less

Webinar Announcement - The Clean Water State Revolving Fund: Flexible Funding for the Urban Tree Canopy

EPA Pesticide Factsheets

This webinar, presented by the EPA and USDA, explores how the CWSRF can be used as a funding source for green infrastructure and urban forestry projects—a cost effective way to reduce combined sewage flooding problems.

77 FR 42693 - Monsanto Company and KWS SAAT AG; Determination of Nonregulated Status of Sugar Beet Genetically...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... for Tolerance to the Herbicide Glyphosate AGENCY: Animal and Plant Health Inspection Service, USDA... engineered for tolerance to the herbicide glyphosate, designated as H7-1, is no longer considered a regulated... as event H7-1, which has been genetically engineered for tolerance to the herbicide glyphosate. The...

PRN 2003-1: Labeling of Pesticide Products under the National Organic Program

EPA Pesticide Factsheets

This notice describes how registrants can obtain EPA approval of label language indicating that all ingredients (active and inert) in a pesticide product and all uses of that pesticide meet the criteria defined in the USDA's National Organic Program Rule.

Automated Geospatial Watershed Assessment (AGWA) Documentation Version 2.0

EPA Science Inventory

The Automated Geospatial Watershed Assessment Http://www.epa.gov/nerlesd1/landsci/agwa/introduction.htm and www.tucson.ars.ag.gov/agwa) tool is a GIS interface jointly developed by the U.S. Environmental Protection Agency, USDA-Agricultural Research Service, University of Arizon...

AGWA: The Automated Geospatial Watershed Assessment Tool

EPA Science Inventory

The Automated Geospatial Watershed Assessment Tool (AGWA, see: www.tucson.ars.ag.gov/agwa or http://www.epa.gov/esd/land-sci/agwa/) is a GIS interface jointly developed by the USDA-Agricultural Research Service, the U.S. Environmental Protection Agency, the University of Arizona...

Automated Geospatial Watershed Assessment Tool (AGWA) Poster Presentation

EPA Science Inventory

The Automated Geospatial Watershed Assessment tool (AGWA, see: www.tucson.ars.ag.gov/agwa or http://www.epa.gov/esd/land-sci/agwa/) is a GIS interface jointly developed by the USDA-Agricultural Research Service, the U.S. Environmental Protection Agency, the University of Arizona...

DISTRIBUTION OF DIOXINS, FURANS, AND COPLANAR PCBS IN DIFFERENT FAT MATRICES IN CATTLE

EPA Science Inventory

The United States Environmental Protection Agency (EPA) and the United States Department of Agriculture (USDA) recently collaborated on a statistically-based, national survey of dioxin-like compounds, including dioxins, furans, and coplanar PCBs, in the back fat from slaughtered ...

Notice of Release: 'Stress tolerant smooth bromegrass STSB'

USDA-ARS?s Scientific Manuscript database

The Agricultural Research Service, U.S. Department of Agriculture announces the release of a stress tolerant smooth bromegrass (STSB) [Bromus inermys, Leyss.] germplasm (PI xxxx) developed by Dr. Bryan K. Kindiger at the USDA-ARS Grazinglands Research Laboratory, El Reno, OK 73036. STSB is release...

Test Guidelines for Pesticides and Toxic Substances

EPA Pesticide Factsheets

Documents that specify methods EPA recommends to generate data submitted to EPA to support the registration of a pesticide, setting of a tolerance or tolerance exemption for pesticide residues, or the decision making process for an industrial chemical.

EXTERNAL PEER REVIEW OF THE DRAFT REGION 4 ...

EPA Pesticide Factsheets

EPA scientists in Region 4 (Atlanta) conducted a review of data and information regarding hypoxia in the northern Gulf of Mexico. This Region 4 staff assessment concluded that phosphorus, rather than nitrogen, may be the limiting nutrient controlling Gulf hypoxia. An unauthorized draft of the report was released in January of 2004. This report, because of its controversial conclusion regarding the role of phosphorus in Gulf hypoxia, caused a significant amount of concern among stakeholders. After considerable internal review by Region 4 EPA scientists, the Region released a significantly revised version of the draft report for a broader internal EPA review in April 2004. The report was revised based on the broader EPA review and released to the Hypoxia Task Force in August 2004, as an informational document with the specific purpose of encouraging discussion and posing questions for the reassessment of the Action Plan. The draft report,

Automated Geospatial Watershed Assessment Tool (AGWA)

USDA-ARS?s Scientific Manuscript database

The Automated Geospatial Watershed Assessment tool (AGWA, see: www.tucson.ars.ag.gov/agwa or http://www.epa.gov/esd/land-sci/agwa/) is a GIS interface jointly developed by the USDA Agricultural Research Service, the U.S. Environmental Protection Agency, the University of Arizona, and the University ...

7 CFR 634.50 - Program and project monitoring and evaluation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Secretary for Conservation, Research and Education, USDA, the Director of Economics, Policy Analysis, and... representatives working through NRCWCC. (3) Evaluative reports for the program and each project area will be submitted annually to the Secretary of Agriculture and the Administrator, EPA. (c) Funding. (1) Research...

7 CFR 634.50 - Program and project monitoring and evaluation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Secretary for Conservation, Research and Education, USDA, the Director of Economics, Policy Analysis, and... representatives working through NRCWCC. (3) Evaluative reports for the program and each project area will be submitted annually to the Secretary of Agriculture and the Administrator, EPA. (c) Funding. (1) Research...

7 CFR 634.50 - Program and project monitoring and evaluation.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Secretary for Conservation, Research and Education, USDA, the Director of Economics, Policy Analysis, and... representatives working through NRCWCC. (3) Evaluative reports for the program and each project area will be submitted annually to the Secretary of Agriculture and the Administrator, EPA. (c) Funding. (1) Research...

7 CFR 634.50 - Program and project monitoring and evaluation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Secretary for Conservation, Research and Education, USDA, the Director of Economics, Policy Analysis, and... representatives working through NRCWCC. (3) Evaluative reports for the program and each project area will be submitted annually to the Secretary of Agriculture and the Administrator, EPA. (c) Funding. (1) Research...

7 CFR 634.50 - Program and project monitoring and evaluation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Secretary for Conservation, Research and Education, USDA, the Director of Economics, Policy Analysis, and... representatives working through NRCWCC. (3) Evaluative reports for the program and each project area will be submitted annually to the Secretary of Agriculture and the Administrator, EPA. (c) Funding. (1) Research...

A STATISTICAL SURVEY OF DIOXIN-LIKE COMPOUNDS IN U.S. POULTRY FAT

EPA Science Inventory

The paper reports on the results of a joint survey of the United States Department of Agriculture (USDA) and the United States Environmental Protection Agency (EPA) on the rate of occurrence and concentration of chlorinated dibenzo-p-dioxins (CDDs), chlorinated dibenzofurans (CDF...

Order Denying Petition to Revoke All Tolerances for the Pesticide Chlorpyrifos

EPA Pesticide Factsheets

In this Order, EPA denies a petition requesting that EPA revoke all tolerances for the pesticide chlorpyrifos under section 408(d) of the Federal Food, Drug, and Cosmetic Act and cancel all chlorpyrifos registrations under FIFRA.

Collaboration in Action: Office of Research and Development (ORD) at the US Environmental Protection Agency (USEPA)-Current Wildfire Program

EPA Science Inventory

The "Collaboration in Action: US EPA's Office of Research and Develop - Current Wildfire Research Program" was invited by the USDA's US Forest Service's Scientific Executive Committee to provide USFS scientific leadership active and potential future opportunities for co...

77 FR 56749 - Gulf Coast Ecosystem Restoration

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... water supplies. The inclusion of EPA and USDA as trustees participating in the Natural Resource Damage... laws of the United States of America, including section 311 of the Federal Water Pollution Control Act... solely in connection with injury to, destruction of, loss of, or loss of use of natural resources...

SUBSURFACE CHARACTERIZATION OF UPLAND RIPARIAN MEADOWS IN CENTRAL NEVADA USING AN INNOVATIVE DIRECT-PUSH EXPLORATION RIG

EPA Science Inventory

The U.S. EPA and the USDA Forest Service are conducting a joint investigation to better understand the interactions between geomorphology, hydrology, and vegetation associated with riparian meadow ecosystems in upland watersheds in central Nevada. Stream incision is a major threa...

Antibiotics in agroecosystems: state of the science “ARASOS” workshop summary

USDA-ARS?s Scientific Manuscript database

In August 2014, the Biosphere2 Conference Center in Oracle, Arizona was the site of a sunny three-day workshop on “Antibiotics in Agroecosystems: State of the Science.” Attended by 42 people, participants included scientists and others from academia, government agencies (including EPA and USDA), an...

How EPA Uses Dietary data from USDA for Exposure Assessments

USDA-ARS?s Scientific Manuscript database

Background: To present the procedures the US Environmental Protection Agency’s (EPA’s) Office of Pesticide Programs (OPP) uses to update the estimates of dietary exposure to pesticides using the consumption data from the National Health and Nutrition Survey, What We Eat in America and methodology a...

DEVELOPMENT OF DURATION-CURVE BASED METHODS FOR QUALIFYING VARIABILITY AND CHANGE IN WATERSHED HYDROLOGY AND WATER QUALITY

EPA Science Inventory

During the past decades, U.S. Environmental Protection Agency (EPA), U.S. Department of Agriculture (USDA) and other Federal program administrative and regulatory agencies spent considerable amounts of time and money to manage risks to surface waters associated with agricultural ...

[Benchmarking in ambulatory care practices--The European Practice Assessment (EPA)].

PubMed

Szecsenyi, Joachim; Broge, Björn; Willms, Sara; Brodowski, Marc; Götz, Katja

2011-01-01

The European Practice Assessment (EPA) is a comprehensive quality management which consists of 220 indicators covering 5 domains (infrastructure, people, information, finance, and quality and safety). The aim of the project presented was to evaluate EPA as an instrument for benchmarking in ambulatory care practices. A before-and-after design with a comparison group was chosen. One hundred and two practices conducted EPA at baseline (t1) and at the 3-year follow-up (t2). A further 209 practices began EPA at t2 (comparison group). Since both practice groups differed in several variables (age of GP, location and size of practice), a matched-pair design based on propensity scores was applied leading to a subgroup of 102 comparable practices (out of the 209 practices). Data analysis was carried out using Z scores of the EPA domains. The results showed significant improvements in all domains between t1 and t2 as well as between the comparison group and t2. Furthermore, the results demonstrate that the implementation of total quality management and the re-assessment of the EPA procedure can lead to significant improvements in almost all domains. Copyright © 2011. Published by Elsevier GmbH.

Contacts in the Office of Pesticide Programs, Pesticide Re-Evaluation Division

EPA Pesticide Factsheets

Contact the Pesticide Re-Evaluation Division (PRD) about registration review and reregistration follow up (including post-RED activities, product reregistration, and implementing certain tolerance reassessment decisions) for conventional pesticides.

77 FR 46306 - Fluxapyroxad; Pesticide Tolerances Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-03

...; Pesticide Tolerances Technical Amendment AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule; technical amendment. SUMMARY: EPA issued a final rule in the Federal Register of May 14, 2012, concerning.... Inadvertently, the terminology for the oilseed crop group and for dried plums was incorrect. This technical...

Modeling adverse event counts in phase I clinical trials of a cytotoxic agent.

PubMed

Muenz, Daniel G; Braun, Thomas M; Taylor, Jeremy Mg

2018-05-01

Background/Aims The goal of phase I clinical trials for cytotoxic agents is to find the maximum dose with an acceptable risk of severe toxicity. The most common designs for these dose-finding trials use a binary outcome indicating whether a patient had a dose-limiting toxicity. However, a patient may experience multiple toxicities, with each toxicity assigned an ordinal severity score. The binary response is then obtained by dichotomizing a patient's richer set of data. We contribute to the growing literature on new models to exploit this richer toxicity data, with the goal of improving the efficiency in estimating the maximum tolerated dose. Methods We develop three new, related models that make use of the total number of dose-limiting and low-level toxicities a patient experiences. We use these models to estimate the probability of having at least one dose-limiting toxicity as a function of dose. In a simulation study, we evaluate how often our models select the true maximum tolerated dose, and we compare our models with the continual reassessment method, which uses binary data. Results Across a variety of simulation settings, we find that our models compare well against the continual reassessment method in terms of selecting the true optimal dose. In particular, one of our models which uses dose-limiting and low-level toxicity counts beats or ties the other models, including the continual reassessment method, in all scenarios except the one in which the true optimal dose is the highest dose available. We also find that our models, when not selecting the true optimal dose, tend to err by picking lower, safer doses, while the continual reassessment method errs more toward toxic doses. Conclusion Using dose-limiting and low-level toxicity counts, which are easily obtained from data already routinely collected, is a promising way to improve the efficiency in finding the true maximum tolerated dose in phase I trials.

77 FR 41363 - BASF Plant Science, LP; Availability of Petition for Determination of Nonregulated Status of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... Genetically Engineered for Herbicide Tolerance AGENCY: Animal and Plant Health Inspection Service, USDA... herbicides in the imidazolinone family. The petition has been submitted in accordance with our regulations... event BPS-CV127-9, which has been genetically engineered for tolerance to herbicides in the...

77 FR 41361 - Dow AgroSciences LLC; Availability of Petition for Determination of Nonregulated Status of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... Genetically Engineered for Herbicide Tolerance AGENCY: Animal and Plant Health Inspection Service, USDA... broadleaf herbicides in the phenoxy auxin group (such as the herbicide 2,4-D) and the herbicides glyphosate...-44406-6, which has been genetically engineered for tolerance to broadleaf herbicides in the phenoxy...

77 FR 75039 - Propiconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

...- 671A) is available to enforce the tolerance expression. The method may be requested from: Chief... action, identified by docket identification (ID) number EPA-HQ-OPP-2011-0772, is available at http://www... additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER INFORMATION...

CACODYLIC ACID (DMAV): METABOLISM AND ...

EPA Pesticide Factsheets

The cacodylic acid (DMAV) issue paper discusses the metabolism and pharmacokinetics of the various arsenical chemicals; evaluates the appropriate dataset to quantify the potential cancer risk to the organic arsenical herbicides; provides an evaluation of the mode of carcinogenic action (MOA) for DMAV including a consideration of the key events for bladder tumor formation in rats, other potential modes of action; and also considers the human relevance of the proposed animal MOA. As part of tolerance reassessment under the Food Quality Protection Act for the August 3, 2006 deadline, the hazard of cacodylic acid is being reassessed.

Spatial Analysis for Monitoring Forest Health

Treesearch

Francis A. Roesch

1994-01-01

A plan for the spatial analysis for the sample design for the detection monitoring phase in the joint USDA Forest Service/EPA Forest Health Monitoring Program (FHM) in the United States is discussed. The spatial analysis procedure is intended to more quickly identify changes in forest health by providing increased sensitivity to localized changes. The procedure is...

77 FR 5012 - Environmental Protection Agency, Department of Health and Human Services and Department of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-9328-7] Environmental Protection Agency, Department of Health and Human Services and Department of Agriculture; Memorandum of Understanding Regarding... Department of Human Services (HHS) and the U.S. Department of Agriculture (USDA). HHS's Centers for Disease...

Second interagency conference on research in the watersheds

Treesearch

Kelly Elder; Kate Dwire; Robert Hubbard; Charles Rhoades; Sandra Ryan; Mike Young; Laurie Porth; Mark Dixon; Angue Goodbody

2006-01-01

The report comprises papers and abstracts from the Second Interagency Conference on Research in the Watersheds, May 16-18, Coweeta Hydrologic Laboratory, Otto NC. Authors from several agencies (e.g., USDA ARS, US-EPA, USFS) and the private sector contributed papers on topics ranging from new technology and analytical procedures, modeling, and hydrologic responses to...

AUTOMATED GEOSPATIAL WATERSHED ASSESSMENT (AGWA): A GIS-BASED HYDROLOGICAL MODELING TOOL FOR WATERSHED MANAGEMENT AND LANDSCAPE ASSESSMENT

EPA Science Inventory

The Automated Geospatial Watershed Assessment (http://www.epa.gov/nerlesd1/land-sci/agwa/introduction.htm and www.tucson.ars.ag.gov/agwa) tool is a GIS interface jointly developed by the U.S. Environmental Protection Agency, USDA-Agricultural Research Service, and the University ...

A STUDY TO EVALUATE THE LEVELS OF DIOXIN-LIKE COMPOUNDS IN DAIRY FEEDS IN THE U.S.

EPA Science Inventory

The Environmental Protection Agency (EPA), in cooperation with USDA and the US Food and Drug Administration (FDA), has undertaken a program to study the presence of dioxin-like compounds in animal feeds. Two phases of this program have been completed, and this paper reports on t...

ROE Carbon Storage - Forest Biomass

EPA Pesticide Factsheets

This polygon dataset depicts the density of forest biomass in counties across the United States, in terms of metric tons of carbon per square mile of land area. These data were provided in spreadsheet form by the U.S. Department of Agriculture (USDA) Forest Service. To produce the Web mapping application, EPA joined the spreadsheet with a shapefile of U.S. county (and county equivalent) boundaries downloaded from the U.S. Census Bureau. EPA calculated biomass density based on the area of each county polygon. These data sets were converted into a single polygon feature class inside a file geodatabase.

Lawn Care Pesticides. Risks Remain Uncertain While Prohibited Safety Claims Continue

DTIC Science & Technology

1990-03-23

Trade Commission (FrC), under its own legislative authority to protect consumers against false and deceptive advertising , can take enforcement action...vides to the public about the safety of its products, federal enforcement actions taken against lawn care pesticide safety advertising claims, and...in reassessing the risks of these pesticides. FIFRA also authorizes EPA to take enforcement action against advertising claims made by pesticide

75 FR 67945 - Monsanto Company and KWS SAAT AG; Availability of an Environmental Assessment for Supplemental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-04

... To Be Tolerant to the Herbicide Glyphosate AGENCY: Animal and Plant Health Inspection Service, USDA... herbicide glyphosate, or for similar administrative action to authorize the continued cultivation of the GE... (EA) for event H7-1 sugar beets, which have been genetically engineered for tolerance to the herbicide...

TRANSPORT AND FATE OF NITRATE AND PATHOGENS AT A DAIRY LAGOON WATER APPLICATION SITE: AN ASSESSMENT OF CNMP PERFORMANCE (GWERD IAG WITH USDA-ARS, #TDB)

EPA Science Inventory

EPA currently requires that application of Concentrated Animal Feeding Operation (CAFO) wastes to agricultural fields follows a Comprehensive Nutrient Management Plan (CNMP). The tacit assumption is that a well designed and executed CNMP ensures that all lagoon water contaminants...

Fire Science Strategy: Resource Conservation and Climate Change

DTIC Science & Technology

2014-09-01

SMOKE MANAGEMENT ISSUES: CONCLUSIONS—KEY RESEARCH/DEMONSTRATION GAPS COVER PHOTO: CHONG, JOEY 2011. USDA FOREST SERVICE. FORT JACKSON...Fire Science Program LiDAR Light Detection and Ranging LANL Los Alamos National Lab NASA National Aeronautics and Space Administration NCAR...entities include the National Aeronautics and Space Administration ( NASA ), EPA, National Center for Atmospheric Research (NCAR), National Institute of

Inert Reassessment Document for Propylene glycol alginate - CAS No. 9005-37-2

EPA Pesticide Factsheets

As an inert pesticide ingredient, propylene glycol alginate is exempt from the requirement for a tolerance when used as a deforming agent in pesticide formulations applies to growing crops, or to raw agricultural commodities after harvest.

Summary of operations and performance of the Murdock site restoration project in 2007.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

This document summarizes the performance of the groundwater and surface water restoration systems installed by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) at the former CCC/USDA grain storage facility in Murdock, Nebraska, during the second full year of system operation, from January 1 through December 31, 2007. Performance in June 2005 through December 2006 was reported previously (Argonne 2007). In the Murdock project, several innovative technologies are being used to remove carbon tetrachloride contamination from a shallow aquifer underlying the town, as well as from water naturally discharged to the surface at the headwaters of amore » small creek (a tributary to Pawnee Creek) north of the town (Figure 1.1). The restoration activities at Murdock are being conducted by the CCC/USDA as a non-time-critical removal action under the regulatory authority and supervision of the U.S. Environmental Protection Agency (EPA), Region VII. Argonne National Laboratory assisted the CCC/USDA by providing technical oversight for the restoration effort and facilities during this review period. Included in this report are the results of all sampling and monitoring activities performed in accord with the EPA-approved Monitoring Plan for this site (Argonne 2006), as well as additional investigative activities conducted during the review period. The annual performance reports for the Murdock project assemble information that will become part of the five-year review and evaluation of the remediation effort. This review will occur in 2010. This document presents overviews of the treatment facilities (Section 2) and site operations and activities (Section 3), then describes the groundwater, surface water, vegetation, and atmospheric monitoring results (Section 4) and modifications and costs during the review period (Section 5). Section 6 summarizes the current period of operation. A gallery of photographs of the Murdock project is in Appendix A. A brief videorecording of the trees in high-wind conditions is on the compact disc (CD) inside the back cover of this document.« less

Summary of operations and performance of the Murdock site restoration project in 2008.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

This document summarizes the performance of the groundwater and surface water restoration systems installed by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) at the former CCC/USDA grain storage facility in Murdock, Nebraska, during the third full year of system operation, from January 1 through December 31, 2008. Performance in June 2005 through December 2007 was reported previously (Argonne 2007, 2008). In the Murdock project, several innovative technologies are being used to remove carbon tetrachloride contamination from a shallow aquifer underlying the town, as well as from water naturally discharged to the surface at the headwaters ofmore » a small creek (a tributary to Pawnee Creek) north of the town (Figure 1.1). The restoration activities at Murdock are being conducted by the CCC/USDA as a non-time-critical removal action under the regulatory authority and supervision of the U.S. Environmental Protection Agency (EPA), Region VII. Argonne National Laboratory assisted the CCC/USDA by providing technical oversight for the restoration effort and facilities during this review period. Included in this report are the results of all sampling and monitoring activities performed in accord with the EPA-approved Monitoring Plan for this site (Argonne 2006), as well as additional investigative activities conducted during the review period. The annual performance reports for the Murdock project assemble information that will become part of the five-year review and evaluation of the remediation effort. This review will occur in 2010. This document presents overviews of the treatment facilities (Section 2) and site operations and activities (Section 3), then describes the groundwater, surface water, vegetation, and atmospheric monitoring results (Section 4) and modifications and costs during the review period (Section 5). Section 6 summarizes the current period of operation. A gallery of photographs of the Murdock project is in Appendix A.« less

Registration of four post-flowering drought tolerant grain sorghum lines with early season cold tolerance

USDA-ARS?s Scientific Manuscript database

Four sorghum (Sorghum bicolor L.) germplasm lines— PSLS-SGCTB01 (Reg. No.), PSLS-SGCTR02 (Reg. No.), PSLS-SGCTB03 (Reg. No.) and PSLS-SGCTB04 (Reg. No.) — were developed by the USDA-ARS in Lubbock TX, in 2017. The primary purpose for the release of these lines is to provide an alternative germplasm ...

R2 Water Quality Portal Monitoring Stations

EPA Pesticide Factsheets

The Water Quality Data Portal (WQP) provides an easy way to access data stored in various large water quality databases. The WQP provides various input parameters on the form including location, site, sampling, and date parameters to filter and customize the returned results. The The Water Quality Portal (WQP) is a cooperative service sponsored by the United States Geological Survey (USGS), the Environmental Protection Agency (EPA) and the National Water Quality Monitoring Council (NWQMC) that integrates publicly available water quality data from the USGS National Water Information System (NWIS) the EPA STOrage and RETrieval (STORET) Data Warehouse, and the USDA ARS Sustaining The Earth??s Watersheds - Agricultural Research Database System (STEWARDS).

Inert Reassessment Document for Dimethyl Ether - CAS No. 115-10-6

EPA Pesticide Factsheets

The existing dimethyl ether exemption from the requirement of a tolerance under 40 CFR 180.930 is for use on animals only. Dimethyl ether is used as an inert ingredient in a variety of livestock insect sprays and foggers.

Activities of the Federal Interagency Workgroup on ...

EPA Pesticide Factsheets

In 2012, four federal agencies signed a Memorandum of Understanding (MOU) establishing a formal mechanism to improve and sustain federal coordination and collaboration on issues related to pharmaceuticals in water. The MOU is in response to the Government Accountability Office recommendation in its August 2011 report “Action Needed to Sustain Agencies’ Collaboration on Pharmaceuticals in Drinking Water.” The signatories are the US Environmental Protection Agency (EPA), US Department of Agriculture/Agricultural Research Service (USDA), US Department of Health and Human Services/Food and Drug Administration (FDA), and US Department of Interior/Geological Survey (USGS). As a result of this agreement, an interagency workgroup (EPA, USGS, FDA, USDA, Army Public Health Center (Provisional), National Toxicology Program, National Oceanic and Atmospheric Administration, and Center for Disease Control and Prevention) was formed to address issues related to the occurrence of pharmaceuticals in water. This Workgroup provides a forum for the exchange of information on pharmaceuticals in the environment, supports coordination of joint studies on pharmaceuticals in the environment, and facilitates interagency consultation on implications of research and analyses derived from shared information. The Workgroup is currently developing a product that will summarize ongoing federal efforts in this area and describe the process for monitoring, evaluating, and reporting to the

40 CFR 176.9 - Publication of a tolerance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Publication of a tolerance. 176.9... TIME-LIMITED TOLERANCES FOR EMERGENCY EXEMPTIONS § 176.9 Publication of a tolerance. (a) If EPA issues... tolerance under this part may be established without prior publication of a proposed tolerance or comment...

75 FR 37738 - 1-Naphthaleneacetic Acid; Time-Limited Tolerance, Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

...-Naphthaleneacetic Acid; Time-Limited Tolerance, Technical Correction AGENCY: Environmental Protection Agency (EPA..., ethylene oxide, fenvalerate, et al.; tolerance actions. Today's rule restores the time-limited tolerance...-3) establishing a time-limited tolerance for residues of 1-naphthaleneacetic acid ethyl ester in or...

Analysis of Total Food Intake and Composition of Individual's ...

EPA Pesticide Factsheets

EPA released the final report, Analysis of Total Food Intake and Composition of Individual’s Diet Based on USDA’s 1994-1996, 98 Continuing Survey of Food Intakes by Individuals (CSFII). The consumption of food by the general population is a significant route of potential exposure to hazardous substances that are present in the environment. For this reason, a thorough analysis of the dietary habits of the American public would aid in the identification of potential exposure pathways. To that end, the EPA developed per capita food intake rates for various food items and food categories using databases developed by the United States Department of Agriculture (USDA). These intake rates were incorporated into EPA's 1997 Exposure Factors Handbook. Since that time, EPA has recommended that the food intake study be updated and expanded to include a more comprehensive analysis of food intake. That analysis is presented in this document. The purpose of this study is to characterize the consumption of food by the people of the United States.

IRIS Toxicological Review of Beryllium and Compounds (2008 ...

EPA Pesticide Factsheets

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Beryllium that when finalized will appear on the Integrated Risk Information System (IRIS) database. An IRIS Toxicological Review of Beryllium and Compounds was published in 1988 and reassessed in 1998. The current draft (2007) only focuses on the cancer assessment and does not re-evaluate posted reference doses or reference concentrations.

DETERMINATION OF 2,3,7,8 CHLORINE-SUBSTITUTED DIBENZO-P-DIOXINS AND FURANS AT THE PART PER TRILLION LEVEL IN UNITED STATES BEEF FAT USING HIGH-RESOLUTION GAS CHROMATOGRAPHY/HIGH-RESOLUTION MASS SPECTROMETRY

EPA Science Inventory

As part of the U.S. EPA Dioxin Reassessment Program, the 2,3,7,8-chlorine-substituted dibenzo-p-dioxins and furans were measured at part per trillion (ppt) levels in beef fat collected from slaughter facilities in the United States. This is the first statistically designed natio...

Revoking Pesticide Tolerances

EPA Pesticide Factsheets

EPA revokes pesticide tolerances when all registrations of a pesticide have been canceled in the U.S. and the tolerances are not needed for imported foods or when there are no registered uses for certain crops.

75 FR 8299 - Draft Environmental Impact Statement; Determination of Regulated Status of Alfalfa Genetically...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Engineered for Tolerance to the Herbicide Glyphosate AGENCY: Animal and Plant Health Inspection Service, USDA... to the herbicide glyphosate. State issued photo identification is required and all bags will be...

75 FR 1585 - Draft Environmental Impact Statement; Determination of Regulated Status of Alfalfa Genetically...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-12

... Engineered for Tolerance to the Herbicide Glyphosate AGENCY: Animal and Plant Health Inspection Service, USDA... to the herbicide glyphosate. State issued photo identification is required and all bags will be...

IMPLICATIONS OF FISH MOVEMENT AND SEASONAL HABITAT DYNAMICS FOR RESTORATION PLANNING AND PRIORITIZATION

EPA Science Inventory

J. L. Ebersole1*, S.G. Leibowitz1, P.J. Wigington Jr. 1, J.P. Baker1, M.A. Cairns1, M.R. Church1, J. Compton1, B. Hansen2, B. Miller3 1 Environmental Protection Agency, 200 SW 35th St., Corvallis, OR 97333, 541-754-4775 (w), 541-754-4799 (f), ebersole.joe@epa.gov 2 USDA, Fo...

Tn5-Mob transposon mediated transfer of salt tolerance and symbiotic characteristics between Rhizobia genera.

PubMed

Yang, S; Wu, Z; Gao, W; Li, J

1993-01-01

Rhizobium meliloti 042B is a fast-growing, salt-tolerant and high efficiency nitrogen-fixing symbiont with alfalfa. Bradyrhizobium japonicum USDA110 grows slowly, and cannot grow in YMA medium containing 0.1M NaCl, but nodulates and fixed nitrogen efficiently with soybean. Eighty-six transconjugants, called SR, were obtained by inserting Tn5-Mob randomly into genomes of 042B using pSUP5011 and helper plasmid RP4. Selecting 4 SR strains randomly and introducing DNA fragment of SR into USDA110 with helper plasmid R68.45 by triparental mating, 106 transconjugants, called BSR, were constructed. Most of BSR strains had the fast-growing phenotype and could tolerate 0.3-0.5M NaCl generally. Some of them produced melanine. When soybean and alfalfa were inoculated with these transconjugants BSR, 47 out of 90 BSR were found to nodulate in both of these plants, but no nitrogenase activity was observed with alfalfa; 26 strains could only nodulate and fix nitrogen in soybean; 13 strains could nodulate in alfalfa but did not fix nitrogen; 4 strains failed to nodulate in either soybean or alfalfa. Among them, 4 transconjugants which tolerated and fixed nitrogen efficiently in soybean were constructed.

EnviroAtlas -- Memphis, TN (2012) -- One Meter Resolution Urban Land Cover Data Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas ). The Memphis, TN EnviroAtlas One Meter-scale Urban Land Cover (MULC) dataset comprises 2,733 km2 around the city of Memphis, surrounding towns, and rural areas. These leaf-on LC data and maps were derived from 1-m pixel, four-band (red, green, blue, and near-infrared) aerial photography acquired from the United States Department of Agriculture (USDA) National Agriculture Imagery Program (NAIP) on four dates in 2012: June 15, June 18, June 21 and June 23, and one date in 2013: July 12. Three separate LiDAR (Light Detection and Ranging) data sets collected on February 19, 2009 00e2?? August 2, 2010, December 1-2, 2011 and January 23-24, 2012 were integrated for Shelby Co., TN, Crittenden Co., AR, and DeSoto Co, MS. Five MULC classes were mapped directly from the NAIP and LiDAR data: Water, Impervious, Soil, Trees, and Grass/Herbaceous. Agriculture was derived from USDA Common Land Unit (CLU) data. Woody and emergent wetlands were copied from existing National Wetlands Inventory (NWI) data. Analysis of a random sampling of 612 photo-interpreted land cover reference points yielded an overall users accuracy of 86.9%. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-u

77 FR 48902 - S-Metolachlor; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... or hearing request, identified by docket ID number EPA-HQ-OPP-2011-0657, by one of the following... registrant, which is available in the docket, http://www.regulations.gov . EPA received one comment to the... relationship of the results of the studies to human risk. EPA has also considered available information...

77 FR 30402 - Acibenzolar- S -methyl; Time-Limited Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

...)(2)(D) of FFDCA, EPA has reviewed the available scientific data and other relevant information in support of this action. EPA has sufficient data to assess the hazards of and to make a determination on.... Toxicological Profile EPA has evaluated the available toxicity data and considered its validity, completeness...

Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study.

PubMed

Tatsuno, Ichiro; Saito, Yasushi; Kudou, Kentarou; Ootake, Jun

2013-01-01

TAK-085 is an omega-3 preparation that contains eicosapentaenoic acid ethyl-ester (EPA-E) and docosahexaenoic acid-ethyl ester used in the management of hypertriglyceridemia. The aim of the study was to evaluate the long-term safety (adverse events [AEs], laboratory parameters, vital signs, weight, and electrocardiograms) and effects on lipid profiles, especially triglyceride levels, of TAK-085 in Japanese patients with hypertriglyceridemia (triglyceride levels ≥150 mg/dL and <750 mg/dL). In this multicenter, open-label, randomized study, adults with hypertriglyceridemia undergoing lifestyle modification received TAK-085 2 g (2 g once daily; n = 165) or 4 g (2 g twice daily; n = 171), or EPA-E 1.8 g (0.6 g three times daily; n = 167) for 52 weeks. Patients were stratified for co-administration of a statin. TAK-085 was well tolerated throughout the 52-week study. Overall, no substantial differences were found in the tolerability of TAK-085 2 g, TAK-085 4 g, and EPA-E 1.8 g with incidence rates for AEs of 83.6%, 86.0%, and 89.2%, respectively. Most AEs were mild or moderate in severity. Triglyceride levels decreased from baseline in all groups by week 4, and the decreases were maintained throughout the study. At week 52 the reduction in triglycerides with TAK-085 2 g (-13.9%) was similar to that with EPA-E 1.8 g (-12.1%), whereas the reduction seen with TAK-085 4 g (-25.5%) was greater than that with EPA-E 1.8 g, as assessed by point estimates and 95% confidence intervals. TAK-085 was safe and well tolerated for up to 52 weeks of treatment in Japanese patients with hypertriglyceridemia undergoing lifestyle modification. Reductions in triglyceride levels achieved after 4 weeks were maintained at 52 weeks. Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved.

40 CFR 180.498 - Sulfentrazone; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances... Parts per million Asparagus 0.15 Bean, lima, succulent 0.15 Brassica, head and stem, subgroup 5A 0.20... pesticide under section 18 emergency exemptions granted by EPA. Compliance with the tolerance levels...

77 FR 43524 - Acetamiprid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-25

...-CBI objection or hearing request, identified by docket ID number EPA-HQ-OPP-2011-0792, by one of the... available in the docket, http://www.regulations.gov . One comment was received on the notice of filing. EPA... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

77 FR 72984 - Buprofezin Pesticide Tolerances; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2011-0759; FRL-9371-3] Buprofezin..., 2012, concerning buprofezin pesticide tolerances. This document corrects a typographical error. DATES...: Sec. 180.511 Buprofezin; tolerances for residues. (a) * * * Parts per Commodity million...

Reassessing Subjectivity, Criticality, and Inclusivity: Marcuse's Challenge to Adult Education.

ERIC Educational Resources Information Center

Brookfield, Stephen

2002-01-01

Although Herbert Marcuse did not write as an adult educator, his analysis of subjectivity, criticality, and inclusivity has implications for adult education. He demonstrated how apparently humanistic tolerance for diversity can be manipulated to reinforce dominant ideology, and he made a case for aesthetic education as a site for critical…

77 FR 63745 - Buprofezin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

...-1996 and 1998 Nationwide Continuing Surveys of Food Intake by Individuals (CSFII). As to residue levels... Agricultural Statistics Service (USDA/NASS), proprietary market surveys, and the National Pesticide Use... available public and private market survey data for that use, averaging across all observations, and...

78 FR 18511 - Thiamethoxam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... Revised PHI and Tolerance for Pepper and Eggplant (Crop Subgroup 8-10B).'' B. Toxicological Points of... Pepper and Eggplant (Crop Subgroup 8-10B),'' available in the docket EPA-HQ-OPP-2011-0860, at http://www... Tolerance for Tea; and Revised PHI and Tolerance for Pepper and Eggplant (Crop Subgroup 8-10B),'' available...

Protection of Proprietary Data Rights for Data Used to Support Tolerance Exemptions for Inert Ingredients

EPA Pesticide Factsheets

The FFDCA provides both exclusive use and data compensation protections for data that inert ingredient manufacturers submit to EPA to establish or maintain tolerances or tolerance exemptions for these ingredients. Find information about these protections.

76 FR 57657 - Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-16

...] Tetrachlorvinphos; Extension of Time-Limited Interim Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This regulation establishes an extension of time-limited interim..., and Cosmetic Act (FFDCA). The time-limited tolerances expire on March 18, 2013. DATES: This regulation...

EPA CHILDREN'S PESTICIDE EXPOSURE MEASUREMENT PROGRAM

EPA Science Inventory

The U.S. EPA's National Exposure Research Laboratory conducts research in support of the Food Quality Protection Act (FQPA) of 1996. FQPA requires that children's risks to pesticide exposures be considered during the tolerance-setting process. FQPA requires exposure assessme...

THE EPA CHILDREN'S PESTICIDE EXPOSURE MEASUREMENT PROGRAM

EPA Science Inventory

The U.S. EPA's National Exposure Research Laboratory conducts research in support of the Food Quality Protection Act (FQPA)) of 1996. FQPA requires that children's risks to pesticide exposures be considered during the tolerance-setting process. FQPA requires exposure assessme...

77 FR 13502 - Pyriofenone; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... developmental study as an endpoint for assessing acute dietary risk. Typically, abortions observed early in the pregnancy in a developmental toxicity study are assumed to be attributable to a single exposure and thus... Agriculture (USDA) 1994-1996 and 1998 Nationwide Continuing Surveys of Food Intakes by Individuals (CSFII). As...

77 FR 8746 - Indoxacarb; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... regulation establishes tolerances for residues of indoxacarb in or on egg, poultry fat, poultry meat, and... million (ppm); poultry, fat at 0.2 ppm; poultry, meat at 0.06 ppm; and poultry, meat byproducts at 0.06..., fat; poultry, meat; and poultry, meat byproducts. These tolerances were evaluated by EPA based on the...

76 FR 22620 - Triflusulfuron-Methyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

... under the Federal Food, Drug, and Cosmetic Act (FFDCA). DATES: This regulation is effective April 22... Determination of Safety Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance (the legal limit... determination on aggregate exposure for triflusulfuron-methyl, including exposure resulting from the tolerances...

COMPARISON OF OVERALL METABOLISM OF 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN IN CYP1A2(-/-) KNOCKOUT AND C57BL/6N PARENTAL STRAINS OF MICE

EPA Science Inventory

Comparison of Overall Metabolism of 2,3,7,8-TCDD
in CYP1A2 (-/-) Knockout and C57BL/6N Parental Strains of Mice

Heldur Hakk* and Janet J. Diliberto**

* USDA-ARS Biosciences Research Laboratory, P.O. Box 5674, Fargo, ND, USA
** US-EPA ORD, National Health Eff...

DISTRIBUTION OF DIOXINS, FURANS, AND COPLANAR ...

EPA Pesticide Factsheets

The United States Environmental Protection Agency (EPA) and the United States Department of Agriculture (USDA) recently collaborated on a statistically-based, national survey of dioxin-like compounds, including dioxins, furans, and coplanar PCBs, in the back fat from slaughtered cattle. Back fat was selected because it was a matrix that could easily be sampled by the veterinarians at the slaughter establishments. Also, since it was a matrix that was very high in fat content (in the range of 60-90% lipid), the ability to measure the dioxin-like compounds with a given sample volume was maximized. A principal use of the results of the national beef survey is to evaluate the exposure of individuals in the United States to these compounds through consumption of beef. In order to use the data for this purpose, an assumption needs to be made regarding the relationship between lipid concentrations of these compounds in back fat compared to the concentrations in meat products. However, data on the concentrations of these compounds in different cattle fat reservoirs to derive the proper assumption are sparse. There is some information on compounds with similar properties (lipophilic, persistent), including residues of HCB, PBB, and DDT, and these data do suggest that their lipid-based concentrations in various fat reservoirs in cattle are similar. In order to evaluate whether the same can be said of the dioxin-like compounds, the EPA and USDA collaborated on a seco

Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study.

PubMed

Tatsuno, Ichiro; Saito, Yasushi; Kudou, Kentarou; Ootake, Jun

2013-01-01

Hypertriglyceridemia is a risk factor for cardiovascular disease, and clinical practice guidelines advocate treatment to reduce triglyceride (TG) levels. In Japan, an EPA-E (eicosapentaenoic acid-ethyl ester) product has been used clinically for treating dyslipidemia. We investigated the TG-lowering effects of TAK-085 (EPA-E + docosahexaenoic acid-ethyl ester) in comparison with EPA-E in Japanese patients with hypertriglyceridemia (TG ≥150 mg/dL and <750 mg/dL). In this multicenter, 12-week, double-blind study, subjects were stratified for coadministration of a 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor then randomized to TAK-085 2 g once daily (n = 205), TAK-085 2 g twice daily (n = 210), or EPA-E 0.6 g three times daily (n = 195). Each one gram of fatty acid in TAK-085 contains approximately 465 mg of EPA plus 375 mg of docosahexaenoic acid-ethyl as ethyl esters. Guidance on lifestyle modifications was provided throughout. The primary end point was the percent change in TG levels (baseline from end of treatment), which was -10.8 ± 22.6, -22.9 ± 23.1, and -11.2 ± 25.7 in the TAK-085 2 g/day, TAK-085 4 g/day, and EPA-E 1.8 g/day groups, respectively. TAK-085 4 g/day produced a significantly greater reduction in TG than EPA-E 1.8 g/day (P < .0001), whereas TAK-085 2 g/day was not inferior to EPA-E 1.8 g/day. Changes in other lipid parameters were relatively modest. There were no notable safety or tolerability differences between the groups. In Japanese patients with modest hypertriglyceridemia who also underwent lifestyle intervention, TAK-085 4 g/day reduced TG more than EPA-E 1.8 g/day. TAK-085 2 g/day had similar effects on TG as EPA-E 1.8 g/day. TAK-085 was well-tolerated. Copyright © 2013 National Lipid Association. Published by Elsevier Inc. All rights reserved.

The effects of natural and induced short-term floods on four sugarcane accessions

USDA-ARS?s Scientific Manuscript database

A study was initiated at the USDA/ARS Subtropical Horticulture Research Station, Miami, FL to evaluate the potential for flood tolerance in several accessions from Saccharum barberi (Jeswiet) and S. sinense (Roxb. Amend. Jeswiet) sugarcane genera. The experimental design included 4 accessions, Kewal...

76 FR 37769 - Bayer CropScience LP; Availability of Petition, Plant Pest Risk Assessment, and Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2010-0102] Bayer CropScience LP; Availability of Petition, Plant Pest Risk Assessment, and Environmental Assessment... Herbicide Tolerance AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice. SUMMARY: We...

78 FR 13312 - Pioneer Hi-Bred International, Inc.; Availability of Petition, Plant Pest Risk Assessment, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2012-0026] Pioneer Hi-Bred International, Inc.; Availability of Petition, Plant Pest Risk Assessment, and... Tolerance and Insect Resistance AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice...

76 FR 33184 - Tetrachlorvinphos; Proposed Extension of Time-Limited Interim Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... multiple OPs from 2001-2005. Furthermore, the USDA Food Safety and Inspection Service (FSIS) monitors meat... Food, Drug, and Cosmetic Act (FFDCA). DATES: Comments, identified by docket identification (ID) number...? You may be potentially affected by this action if you are an agricultural producer, food manufacturer...

Progress Report on the ISCR Pilot Test Conducted at the Former CCC/USDA Grain Storage Facility in Montgomery City, Missouri, as of April 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, Lorraine M.

The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) is conducting an environmental investigation at the former CCC/USDA grain storage facility on the county fairgrounds in Montgomery City, Missouri, to evaluate contamination associated with the former use of grain fumigants containing carbon tetrachloride at the site. The CCC/USDA studies have identified carbon tetrachloride in the soils (primarily unconsolidated glacial tills) at concentrations that exceed the U.S. Environmental Protection Agency (EPA) regional screening level (RSL) values for this compound in residential soils (610 μg/kg) but are below the corresponding RSL for industrial soils (3,000 μg/kg). Concentrations of carbon tetrachloridemore » greater than the EPA maximum contaminant level (MCL; 5.0 μg/L) for this contaminant in drinking water were also identified in the shallow groundwater (Argonne 2012). On the basis of these findings, remedial actions are considered necessary to mitigate the present and potential future impacts of the contamination. In cooperation with the Missouri Department of Natural Resources (MDNR), the CCC/USDA has initiated a field-scale pilot test to evaluate an in situ technology for treatment of the carbon tetrachloride contamination. In this approach, a chemical amendment consisting primarily of slow-release organic matter and zero-valent iron is employed to induce oxygen-depleted, chemically reducing conditions in the subsurface. These conditions foster the in situ chemical reduction (ISCR) of carbon tetrachloride and its degradation products (chloroform, methylene chloride, and chloromethane) via both inorganic and biologically mediated processes. The chemical amendment being used, EHC™, was developed by the Adventus Group, Freeport, Illinois, and is now manufactured and distributed by FMC Environmental Solutions, Philadelphia, Pennsylvania. With the approval of the MDNR (2012), the ISCR technology is being tested in two target areas interpreted to represent contaminant source areas. The pilot test is being implemented on behalf of the CCC/USDA by Argonne National Laboratory. Approximately 80,000 lb of the EHC material was injected by using direct-push techniques at 99 locations in the target areas, from November 9 to December 15, 2012 (Argonne 2012). To determine the geochemical effects of the pilot injections and their impact on the levels of contamination in the test areas, an extended monitoring program (Argonne 2012) is being implemented. The program includes an initial “baseline” sampling event to document pre-treatment conditions and periodic post-injection monitoring events, approximately 1, 2, 4, 6, 9, and 12 months after the completion of the injection program (Argonne 2012). This report provides a brief summary of the specific activities conducted, with a compilation of the monitoring data obtained, during the baseline sampling event (October 2012) and the first, second, and third post-injection monitoring events (in January, February, and April 2013).« less

THE EPA/ORD/NERL'S HUMAN EXPOSURE MEASUREMENTS PROGRAM - CHILDREN'S FOCUS

EPA Science Inventory

The U.S. EPA's National Exposure Research Laboratory (NERL) conducts research in support of the Food Quality Protection Act (FQPA) of 1996. FQPA requires that children's risks to pesticide exposures be considered during the tolerance-setting process. The Act requires exposure...

Particle atlas of World Trade Center dust

USGS Publications Warehouse

Lowers, Heather; Meeker, Gregory P.

2005-01-01

The United States Environmental Protection Agency (EPA) has begun a reassessment of the presence of World Trade Center (WTC) dust in residences, public buildings, and office spaces in New York City, New York. Background dust samples collected from residences, public buildings, and office spaces will be analyzed by multiple laboratories for the presence of WTC dust. Other laboratories are currently studying WTC dust for other purposes, such as health effects studies. To assist in inter-laboratory consistency for identification of WTC dust components, this particle atlas of phases in WTC dust has been compiled.

EnviroAtlas - Big Game Hunting Recreation Demand by 12-Digit HUC in the Conterminous United States

EPA Pesticide Factsheets

This EnviroAtlas dataset includes the total number of recreational days per year demanded by people ages 18 and over for big game hunting by location in the contiguous United States. Big game includes deer, elk, bear, and wild turkey. These values are based on 2010 population distribution, 2011 U.S. Fish and Wildlife Service (FWS) Fish, Hunting, and Wildlife-Associated Recreation (FHWAR) survey data, and 2011 U.S. Department of Agriculture (USDA) Forest Service National Visitor Use Monitoring program data, and have been summarized by 12-digit hydrologic unit code (HUC). This dataset was produced by the US EPA to support research and online mapping activities related to the EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

40 CFR 86.515-78 - EPA urban dynamometer driving schedule.

Code of Federal Regulations, 2010 CFR

2010-07-01

... I(b) (b) The speed tolerance at any given time on the dynamometer driving schedule prescribed in... than the tolerances (such as may occur during gear changes) are acceptable provided they occur for less... requirements of § 86.532 the speed tolerance shall be as specified above, except that the upper and lower...

40 CFR 86.115-78 - EPA urban dynamometer driving schedule.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the target schedule as closely as possible. The speed tolerance at any given time for these schedules... time. (3)(i) Speed variations greater than the tolerances (such as may occur during gear changes or... variations greater than the tolerance are acceptable, provided they occur for less than 15 seconds on any...

76 FR 25281 - Atrazine, Chloroneb, Chlorpyrifos, Clofencet, Endosulfan, et al.; Proposed Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-04

... use of profanity or personal threats. viii. Make sure to submit your comments by the comment period... atrazine, establish tolerances for endosulfan, and make minor revisions to tolerance expressions for a few..., 2011. ADDRESSES: Submit your comments, identified by docket identification (ID) number EPA-HQ-OPP-2011...

40 CFR 180.630 - Flusilazole; tolerances for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

... emergency exemptions granted by EPA. The tolerances expire and are revoked on the dates specified in the following table. Commodity Parts per million Expiration/revocation date Soybean, aspirated grain fractions 2.6 12/31/10 Soybean, seed 0.04 12/31/10 Soybean, oil 0.10 12/31/10 (c) Tolerances with regional...

40 CFR 180.630 - Flusilazole; tolerances for residues.

Code of Federal Regulations, 2014 CFR

2014-07-01

... emergency exemptions granted by EPA. The tolerances expire and are revoked on the dates specified in the following table. Commodity Parts per million Expiration/revocation date Soybean, aspirated grain fractions 2.6 12/31/10 Soybean, seed 0.04 12/31/10 Soybean, oil 0.10 12/31/10 (c) Tolerances with regional...

40 CFR 180.630 - Flusilazole; tolerances for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

... emergency exemptions granted by EPA. The tolerances expire and are revoked on the dates specified in the following table. Commodity Parts per million Expiration/revocation date Soybean, aspirated grain fractions 2.6 12/31/10 Soybean, seed 0.04 12/31/10 Soybean, oil 0.10 12/31/10 (c) Tolerances with regional...

40 CFR 180.630 - Flusilazole; tolerances for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

... emergency exemptions granted by EPA. The tolerances expire and are revoked on the dates specified in the following table. Commodity Parts per million Expiration/revocation date Soybean, aspirated grain fractions 2.6 12/31/10 Soybean, seed 0.04 12/31/10 Soybean, oil 0.10 12/31/10 (c) Tolerances with regional...

77 FR 25661 - Sulfuryl Fluoride; Second Request for Comment on Proposed Order Granting Objections to Tolerances...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... Fluoride; Second Request for Comment on Proposed Order Granting Objections to Tolerances and Denying... on EPA's proposed resolution of objections and a stay request with regard to sulfuryl fluoride and fluoride tolerances promulgated in 2004 and 2005 under section 408(d) of the Federal Food, Drug, and...

75 FR 29475 - Maneb; Proposed Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

..., EPA is proposing to revoke the tolerances in 40 CFR 180.110(a) on almond; apple; banana (not more than 0.5 part per million shall be in the pulp after peel is removed and discarded (preharvest...

THE EPA NATIONAL EXPOSURE RESEARCH LABORATORY CHILDREN'S PESTICIDE EXPOSURE MEASUREMENT PROGRAM

EPA Science Inventory

The U.S. EPA's National Exposure Research Laboratory (NERL) conducts research in support of the Food Quality Protection Act (FQPA) of 1996. FQPA requires that children's risks to pesticide exposures be considered during the tolerance-setting process. The Act requires exposure...

Icosapent ethyl: a review of its use in severe hypertriglyceridemia.

PubMed

Kim, Esther S; McCormack, Paul L

2014-12-01

Icosapent ethyl (Vascepa®) is a high-purity ethyl ester of eicosapentaenoic acid (EPA) that is de-esterified to EPA following oral administration. Both EPA and docosahexaenoic acid (DHA) are long-chain omega-3 fatty acids that have been associated with triglyceride (TG)-lowering. However, DHA has been associated with increased low-density lipoprotein cholesterol (LDL-C) levels. Icosapent ethyl contains ≥96 % of the EPA ethyl ester, does not contain DHA, and is approved in the USA for use as an adjunct to diet to lower TG levels in adult patients with severe (≥500 mg/dL [≥5.65 mmol/L]) hypertriglyceridemia. In a pivotal phase III trial, oral icosapent ethyl 4 g/day significantly decreased the placebo-corrected median TG levels by 33.1 %. It did not increase LDL-C, had favorable effects on other lipid parameters, and had a tolerability profile similar to that of placebo. Therefore, icosapent ethyl is an effective and well-tolerated agent for the treatment of severe hypertriglyceridemia in adults.

Transgenic maize event TC1507: Global status of food, feed, and environmental safety

PubMed Central

Baktavachalam, Gajendra B; Delaney, Bryan; Fisher, Tracey L; Ladics, Gregory S; Layton, Raymond J; Locke, Mary EH; Schmidt, Jean; Anderson, Jennifer A; Weber, Natalie N; Herman, Rod A; Evans, Steven L

2015-01-01

Maize (Zea mays) is a widely cultivated cereal that has been safely consumed by humans and animals for centuries. Transgenic or genetically engineered insect-resistant and herbicide-tolerant maize, are commercially grown on a broad scale. Event TC1507 (OECD unique identifier: DAS-Ø15Ø7–1) or the Herculex®# I trait, an insect-resistant and herbicide-tolerant maize expressing Cry1F and PAT proteins, has been registered for commercial cultivation in the US since 2001. A science-based safety assessment was conducted on TC1507 prior to commercialization. The safety assessment addressed allergenicity; acute oral toxicity; subchronic toxicity; substantial equivalence with conventional comparators, as well as environmental impact. Results from biochemical, physicochemical, and in silico investigations supported the conclusion that Cry1F and PAT proteins are unlikely to be either allergenic or toxic to humans. Also, findings from toxicological and animal feeding studies supported that maize with TC1507 is as safe and nutritious as conventional maize. Maize with TC1507 is not expected to behave differently than conventional maize in terms of its potential for invasiveness, gene flow to wild and weedy relatives, or impact on non-target organisms. These safety conclusions regarding TC1507 were acknowledged by over 20 regulatory agencies including United States Environment Protection Agency (US EPA), US Department of Agriculture (USDA), Canadian Food Inspection Agency (CFIA), and European Food Safety Authority (EFSA) before authorizing cultivation and/or food and feed uses. A comprehensive review of the safety studies on TC1507, as well as some benefits, are presented here to serve as a reference for regulatory agencies and decision makers in other countries where authorization of TC1507 is or will be pursued. PMID:26018138

Transgenic maize event TC1507: Global status of food, feed, and environmental safety.

PubMed

Baktavachalam, Gajendra B; Delaney, Bryan; Fisher, Tracey L; Ladics, Gregory S; Layton, Raymond J; Locke, Mary Eh; Schmidt, Jean; Anderson, Jennifer A; Weber, Natalie N; Herman, Rod A; Evans, Steven L

2015-01-01

Maize (Zea mays) is a widely cultivated cereal that has been safely consumed by humans and animals for centuries. Transgenic or genetically engineered insect-resistant and herbicide-tolerant maize, are commercially grown on a broad scale. Event TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) or the Herculex®(#) I trait, an insect-resistant and herbicide-tolerant maize expressing Cry1F and PAT proteins, has been registered for commercial cultivation in the US since 2001. A science-based safety assessment was conducted on TC1507 prior to commercialization. The safety assessment addressed allergenicity; acute oral toxicity; subchronic toxicity; substantial equivalence with conventional comparators, as well as environmental impact. Results from biochemical, physicochemical, and in silico investigations supported the conclusion that Cry1F and PAT proteins are unlikely to be either allergenic or toxic to humans. Also, findings from toxicological and animal feeding studies supported that maize with TC1507 is as safe and nutritious as conventional maize. Maize with TC1507 is not expected to behave differently than conventional maize in terms of its potential for invasiveness, gene flow to wild and weedy relatives, or impact on non-target organisms. These safety conclusions regarding TC1507 were acknowledged by over 20 regulatory agencies including United States Environment Protection Agency (US EPA), US Department of Agriculture (USDA), Canadian Food Inspection Agency (CFIA), and European Food Safety Authority (EFSA) before authorizing cultivation and/or food and feed uses. A comprehensive review of the safety studies on TC1507, as well as some benefits, are presented here to serve as a reference for regulatory agencies and decision makers in other countries where authorization of TC1507 is or will be pursued.

Fort Collins Science Center

USGS Publications Warehouse

Banowetz, Michele

2004-01-01

FORT serves all Department of the Interior land management bureaus and other natural resource agencies. In addition, FORT scientists partner with DOI and other federal entities such as CDC, DOE, EPA, NASA, NIH, and USDA to share expertise and resources. FORT also partners with several universities and works cooperatively with states and nongovernmental organizations. Products and services include reports and publications, predictive models and software, maps and GIS products, and other technical assistance in the form of meetings, workshops, training, field visits, and needs assessments.

COMPARISON OF OVERALL METABOLISM OF 1, 2, 7, 8-PECDD IN CYP1A2(-L-) KNOCKOUT AND C57BL/6N PARENTAL STRAINS OF MICE

EPA Science Inventory

COMPARISON OF OVERALL METABOLISM OF 1,2,3,7,8-PeCDD
IN CYP1A2 (-/-) KNOCKOUT AND C57BL/6N PARENTAL
STRAINS OF MICE

Heldur Hakk1 and Janet J. Diliberto2

1 USDA-ARS, Biosciences Research Laboratory, P.O. Box 5674, Fargo, ND, USA
2 US EPA, ORD, National Heal...

Integrating transcriptomics and metabolomics to characterize the regulation of EPA biosynthesis in response to cold stress in seaweed Bangia fuscopurpurea.

PubMed

Cao, Min; Wang, Dongmei; Mao, Yunxiang; Kong, Fanna; Bi, Guiqi; Xing, Qikun; Weng, Zhen

2017-01-01

Bangia fuscopurpurea is a traditional mariculture crop having high nutritional value, eicosapntemacnioc acid (EPA) production, and protein content. As an intertidal species, it can tolerate drastic changes in abiotic factors such as temperature, hydration, and light radiation; however, genomic information on the evolutionary aspect and mechanism of EPA enrichment in B. fuscopurpurea and the role of EPA in cold tolerance in this species remain elusive. We conducted transcriptome profile analysis in B. fuscopurpurea to investigate the biological functions of genes associated with resistance to various environment factors. We identified 41,935 unigenes that were assembled and applied to public databases to define their functional annotation (NR, GO, KEGG, KOG, and SwissProt). We further identified genes that encoded key enzymes in EPA biosynthesis; five paralogous genes encoding delta5 desaturase were detected in B. fuscopurpurea. Fatty acid profiling and gene expression analysis of B. fuscopurpurea grown under cold stress were simultaneously performed. The EPA content was increased by 29.8% in the samples grown at 4°C, while the total amount of fatty acids remained unchanged. Moreover, all the EPA biosynthesis-related desaturase and elongase genes were upregulated under cold stress. Thus, we hypothesized that diverse EPA biosynthesis pathways and significant increase in gene copy numbers of fatty acid desaturases, together with the concomitant elevation in the transcriptional level of genes associated with fatty acid metabolism, lead to EPA accumulation and subsequently affect membrane fluidity, contributing to cold stress resistance in B. fuscopurpurea. Our findings not only provide a fundamental genetic background for further research in B. fuscopurpurea, but also have important implications for screening and genetic engineering of algae and plants for EPA production.

Integrating transcriptomics and metabolomics to characterize the regulation of EPA biosynthesis in response to cold stress in seaweed Bangia fuscopurpurea

PubMed Central

Mao, Yunxiang; Kong, Fanna; Bi, Guiqi; Xing, Qikun; Weng, Zhen

2017-01-01

Bangia fuscopurpurea is a traditional mariculture crop having high nutritional value, eicosapntemacnioc acid (EPA) production, and protein content. As an intertidal species, it can tolerate drastic changes in abiotic factors such as temperature, hydration, and light radiation; however, genomic information on the evolutionary aspect and mechanism of EPA enrichment in B. fuscopurpurea and the role of EPA in cold tolerance in this species remain elusive. We conducted transcriptome profile analysis in B. fuscopurpurea to investigate the biological functions of genes associated with resistance to various environment factors. We identified 41,935 unigenes that were assembled and applied to public databases to define their functional annotation (NR, GO, KEGG, KOG, and SwissProt). We further identified genes that encoded key enzymes in EPA biosynthesis; five paralogous genes encoding delta5 desaturase were detected in B. fuscopurpurea. Fatty acid profiling and gene expression analysis of B. fuscopurpurea grown under cold stress were simultaneously performed. The EPA content was increased by 29.8% in the samples grown at 4°C, while the total amount of fatty acids remained unchanged. Moreover, all the EPA biosynthesis-related desaturase and elongase genes were upregulated under cold stress. Thus, we hypothesized that diverse EPA biosynthesis pathways and significant increase in gene copy numbers of fatty acid desaturases, together with the concomitant elevation in the transcriptional level of genes associated with fatty acid metabolism, lead to EPA accumulation and subsequently affect membrane fluidity, contributing to cold stress resistance in B. fuscopurpurea. Our findings not only provide a fundamental genetic background for further research in B. fuscopurpurea, but also have important implications for screening and genetic engineering of algae and plants for EPA production. PMID:29240755

Pesticide Tolerances

EPA Pesticide Factsheets

EPA regulates pesticides used to protect crops and sets limits on the amount of pesticide remaining in or on foods in the U.S. The limits on pesticides on foods are called tolerances in the U.S. (maximum residue limits (MRLs) in many other countries).

77 FR 59114 - Cyazofamid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-26

...; Pesticide Tolerances AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This....regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP Docket) in the... CONTACT: Laura Nollen, Registration Division (7505P), Office of Pesticide Programs, Environmental...

78 FR 48677 - Notice of Receipt of Pesticide Products; Registration Applications to Register New Uses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... application to sorghum containing the ALS-tolerant ``DuPont INZEN Z'' trait. 4. EPA Registration Numbers: 352...: Herbicide. Proposed use: Postemergence application to sorghum containing the ALS-tolerant ``DuPont INZEN Z...

40 CFR 176.5 - Establishment of a time-limited tolerance or exemption.

Code of Federal Regulations, 2010 CFR

2010-07-01

... authorizes an emergency exemption or a crisis exemption. EPA will consider establishing such a tolerance only... exemption, has stated its intention to issue a crisis exemption, or has issued a crisis exemption for a use...

75 FR 50902 - Mancozeb; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

..., peppers and broccoli (PP 4F4333). Therefore, based on these changes, EPA conducted an additional risk...-2005-0541 titled ``Mancozeb: Human Health Risk Assessment to Support Proposed New Uses on Broccoli..., cabbage, leaf lettuce, peppers and broccoli). In the meantime, EPA is moving forward to establish a time...

Registration of ‘Ok101’ Wheat

USDA-ARS?s Scientific Manuscript database

‘Ok101’ (Reg. no. CV-932, PI 631493) is a hard red winter wheat (Triticum aestivum L.) developed cooperatively by the Oklahoma Agricultural Experiment Station and the USDA-ARS, and released in March 2001. Ok101 was released for its high tolerance to acidic soil, broad adaptation to both dual-purpose...

Germplasm morgue or gold mine? Enhancing the value of plant genetic resource collections for plant breeding

USDA-ARS?s Scientific Manuscript database

Genetic diversity is the raw material that plant breeders require to develop cultivars that are productive, nutritious, pest and stress tolerant, and water and nutrient use efficient. The USDA-ARS National Plant Germplasm System (NPGS) contains a wealth of genetic diversity, including improved varie...

78 FR 13308 - Monsanto Co.; Availability of Petition for Determination of Nonregulated Status of Dicamba and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... Tolerant Cotton AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice. SUMMARY: We are... from the Monsanto Company (Monsanto) seeking a determination of nonregulated status of cotton.... Louis, MO, seeking a determination of nonregulated status of cotton designated as event MON 88701, which...

2015 Progress Report – Evaluation of the Cornell-Geneva Apple Rootstocks and Other Promising Apple Rootstocks

USDA-ARS?s Scientific Manuscript database

A number of new apple rootstocks from the Cornell/USDA apple rootstock breeding project, located at Geneva, NY which are resistant to fire blight are rapidly becoming available to the industry. These rootstocks are also dwarfing, tolerant to replant disease and productive. Data on cumulative yield...

The Path for the Development and Release of Heat Tolerant Soybean Lines

USDA-ARS?s Scientific Manuscript database

High ambient temperatures can damage soybean seed. Heat is recognized by the crop insurance industry as a major cause for monetary losses to producers. The USDA Risk Management Agency reported payouts to soybean farmers of more than $247 million on over 1.62 million hectares for losses due to heat...

EnviroAtlas -Pittsburgh, PA- One Meter Resolution Urban Land Cover Data (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas).The EnviroAtlas Pittsburgh, PA land cover map was generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution. Imagery was collected on multiple dates in June 2010. Five land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, and grass and herbaceous non-woody vegetation. An accuracy assessment of 500 completely random and 81 stratified random points yielded an overall accuracy of 86.57 percent. The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Pittsburgh, PA. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas -- Austin, TX -- One Meter Resolution Urban Land Cover Data (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas ). The Austin, TX EnviroAtlas One Meter-scale Urban Land Cover (MULC) Data were generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution from multiple dates in May, 2010. Six land cover classes were mapped: water, impervious surfaces, soil and barren land, trees, grass-herbaceous non-woody vegetation, and agriculture. An accuracy assessment of 600 completely random and 55 stratified random photo interpreted reference points yielded an overall User's fuzzy accuracy of 87 percent. The area mapped is the US Census Bureau's 2010 Urban Statistical Area for Austin, TX plus a 1 km buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas

75 FR 81878 - Imazosulfuron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... e-CFR site at http://www.gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go http://www.epa.gov/ocspp and select ``Test Methods and... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

75 FR 69353 - Isoxaben; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... e-CFR site at http://www.gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

77 FR 52240 - Pendimethalin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

..., identified by docket ID number EPA-HQ-OPP-2011-0521, by one of the following methods: Federal eRulemaking... relationship of the results of the studies to human risk. EPA has also considered available information... subchronic rat and mouse studies was manifested as alterations in thyroid hormones, increased thyroid weight...

78 FR 13264 - Acetochlor; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... one study. In three reproduction toxicity studies in rats, offspring effects (decreased pup weights in... or hearing request, identified by docket ID number EPA-HQ-OPP-2012-0302, by one of the following... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

Achieving a transparent, actionable framework for public-private partnerships for food and nutrition research.

PubMed

Alexander, Nick; Rowe, Sylvia; Brackett, Robert E; Burton-Freeman, Britt; Hentges, Eric J; Kretser, Alison; Klurfeld, David M; Meyers, Linda D; Mukherjea, Ratna; Ohlhorst, Sarah

2015-06-01

Officers and other representatives of more than a dozen food-, nutrition-, and health-related scientific societies and organizations, food industry scientists, and staff of the USDA, the CDC, the Food and Drug Administration, and the NIH convened on 8 December 2014 in Washington, DC, to reach a consensus among individuals participating on guiding principles for the development of research-oriented, food- and nutrition-related public-private partnerships. During the daylong working meeting, participants discussed and revised 12 previously published guidelines to ensure integrity in the conduct of food and nutrition research collaborations among public, nonprofit, and private sectors. They agreed to reconvene periodically to reassess the public-private partnership principles. This article presents the guiding principles and potential benefits, outlines key discussion points, and articulates points of agreement and reservation. © 2015 American Society for Nutrition.

Adaptive Prior Variance Calibration in the Bayesian Continual Reassessment Method

PubMed Central

Zhang, Jin; Braun, Thomas M.; Taylor, Jeremy M.G.

2012-01-01

Use of the Continual Reassessment Method (CRM) and other model-based approaches to design in Phase I clinical trials has increased due to the ability of the CRM to identify the maximum tolerated dose (MTD) better than the 3+3 method. However, the CRM can be sensitive to the variance selected for the prior distribution of the model parameter, especially when a small number of patients are enrolled. While methods have emerged to adaptively select skeletons and to calibrate the prior variance only at the beginning of a trial, there has not been any approach developed to adaptively calibrate the prior variance throughout a trial. We propose three systematic approaches to adaptively calibrate the prior variance during a trial and compare them via simulation to methods proposed to calibrate the variance at the beginning of a trial. PMID:22987660

76 FR 11344 - Difenoconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... be affected. The North American Industrial Classification System (NAICS) codes have been provided to... review of the data supporting the petition, EPA has revised the proposed tolerance for mango, fruit from... there is reliable information.'' This includes exposure through drinking water and in residential...

77 FR 26462 - Dimethomorph; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-04

... affected. The North American Industrial Classification System (NAICS) codes have been provided to assist... review of the data supporting the petitions, EPA has revised the proposed tolerance level and commodity....'' This includes exposure through drinking water and in residential settings, but does not include...

77 FR 40812 - Dicloran and Formetanate; Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-11

... Dicloran and Formetanate; Tolerance Actions AGENCY: Environmental Protection Agency (EPA). ACTION: Final... I.C. of the SUPPLEMENTARY INFORMATION). ADDRESSES: The docket for this action, identified by [email protected] . SUPPLEMENTARY INFORMATION: I. General Information A. Does this action apply to me? You may...

Translational genomics for abiotic stress in sorghum: transcriptional profiling and validation of SNP markers between germplasm with differential cold tolerance

USDA-ARS?s Scientific Manuscript database

One focus of the Sorghum Translational Genomics Lab (part of sorghum CRIS, PSGD, CSRL, USDA-ARS, Lubbock TX) is to utilize nucleotide variation between sorghum germplasm such as those derived from RNA seq for translation and validation of Single Nucleotide Polymorphism (SNP) into easy access DNA m...

Nutrient Composition of Retail Samples of Sorghum, Millet, and Whole Wheat Flour

USDA-ARS?s Scientific Manuscript database

More than 2 million people in the United States have celiac disease, or about 1 in 133 individuals. People who have this disease cannot tolerate gluten, a protein in wheat, rye, and barley. The only treatment for celiac disease is a gluten-free diet. Nutrient profiles were lacking in the USDA Nat...

Genomic Architecture and Phenotypic Plasticity of Forage Quality in Response to Water Deficit in Alfalfa (Medicago sativa L.)

USDA-ARS?s Scientific Manuscript database

A panel of alfalfa cultivars and landraces originated worldwide with potential value of drought tolerance were selected from USDA-Western Region Plant Germplasm Center. Field trials were conducted in the in Roza farm in Prosser, WA and a gradient of water deficits were applied. Aboveground biomass w...

The USDA collection of barley landraces and cultivars: genetic diversity, population structure, and potential for genome-wide association studies

USDA-ARS?s Scientific Manuscript database

New sources of genetic diversity must to be incorporated into plant breeding programs if they are to continue increasing grain yield and quality, and tolerance to abiotic and biotic stresses. Germplasm collections provide a source of genetic and phenotypic diversity, but characterization of these re...

Our Air: Unfit for Trees.

ERIC Educational Resources Information Center

Dochinger, Leon S.

To help urban, suburban, and rural tree owners know about air pollution's effects on trees and their tolerance and intolerance to pollutants, the USDA Forest Service has prepared this booklet. It answers the following questions about atmospheric pollution: Where does it come from? What can it do to trees? and What can we do about it? In addition,…

EnviroAtlas -Pittsburgh, PA- One Meter Resolution Urban Land Cover Data (2010)

EPA Pesticide Factsheets

The EnviroAtlas Pittsburgh, PA land cover map was generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution. Imagery was collected on multiple dates in June 2010. Five land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, and grass and herbaceous non-woody vegetation. An accuracy assessment of 500 completely random and 81 stratified random points yielded an overall accuracy of 86.57 percent. The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Pittsburgh, PA. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas -Durham, NC- One Meter Resolution Urban Area Land Cover Map (2010)

EPA Pesticide Factsheets

The EnviroAtlas Durham, NC land cover map was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from July 2010 at 1 m spatial resolution. Five land cover classes were mapped: impervious surface, soil and barren, grass and herbaceous, trees and forest, and water. An accuracy assessment using a stratified random sampling of 500 samples yielded an overall accuracy of 83 percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Durham, and includes the cities of Durham, Chapel Hill, Carrboro and Hillsborough, NC. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas ) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets ).

EnviroAtlas -Portland, ME- One Meter Resolution Urban Land Cover (2010)

EPA Pesticide Factsheets

The EnviroAtlas Portland, ME land cover map was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from Late Summer 2010 at 1 m spatial resolution. Eight land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, agriculture, and wetlands (woody and emergent). An accuracy assessment using a stratified random sampling of 600 samples yielded an overall accuracy of 87.5 percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Portland. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas -- Austin, TX -- One Meter Resolution Urban Land Cover Data (2010)

EPA Pesticide Factsheets

The Austin, TX EnviroAtlas One Meter-scale Urban Land Cover (MULC) Data were generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution from multiple dates in May, 2010. Six land cover classes were mapped: water, impervious surfaces, soil and barren land, trees, grass-herbaceous non-woody vegetation, and agriculture. An accuracy assessment of 600 completely random and 55 stratified random photo interpreted reference points yielded an overall User's fuzzy accuracy of 87 percent. The area mapped is the US Census Bureau's 2010 Urban Statistical Area for Austin, TX plus a 1 km buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas -Milwaukee, WI- One Meter Resolution Urban Land Cover Data (2010)

EPA Pesticide Factsheets

The EnviroAtlas Milwaukee, WI land cover data and map were generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from Late Summer 2010 at 1 m spatial resolution. Nine land cover classes were mapped: water, impervious surfaces (dark and light), soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, agriculture, and wetlands (woody and emergent). An accuracy assessment using a completely random sampling of 600 samples yielded an overall accuracy of 85.39% percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Milwaukee. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas -- Woodbine, IA -- One Meter Resolution Urban Land Cover Data (2011)

EPA Pesticide Factsheets

The EnviroAtlas Woodbine, IA land cover (LC) data and map were generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from Late Summer 2011 at 1 m spatial resolution. Six land cover classes were mapped: water, impervious surfaces (dark and light), soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, and agriculture. An accuracy assessment using a completely random sampling of 600 samples yielded an overall accuracy of 87.03% percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Woodbine. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

76 FR 54185 - Fenamiphos; Proposed Data Call-In Order for Pesticide Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

... electronic comment, EPA recommends that you include your name and other contact information in the body of... difficulties and cannot contact you for clarification, EPA may not be able to consider your comment. Electronic... available docket materials are available either in the electronic docket at http://www.regulations.gov , or...

76 FR 4542 - Mefenoxam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... comments received in response to the notice of filing. Based upon review of the data supporting the... in section 408(b)(2)(D) of FFDCA, EPA has reviewed the available scientific data and other relevant information in support of this action. EPA has sufficient data to assess the hazards of and to make a...

77 FR 58045 - Clopyralid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... Classification System (NAICS) codes have been provided to assist you and others in determining whether this... data supporting the petition, EPA has determined that the proposed tolerance on rapeseed subgroup 20A... exposure through drinking water and in residential settings, but does not include occupational exposure...

76 FR 18895 - Hexythiazox; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS), the estimated drinking water concentration... Classification System (NAICS) codes have been provided to assist you and others in determining whether this.... Based upon review of the data supporting the petition, EPA has revised the proposed tolerance levels for...

76 FR 50898 - Metconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-17

.../oppefed1/models/water/index.htm . Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System... affected. The North American Industrial Classification System (NAICS) codes have been provided to assist... supporting the petition, EPA has modified the levels at which tolerances are being established for the...

78 FR 25396 - Glyphosate; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

.../water/index.htm . Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS.... The following list of North American Industrial Classification System (NAICS) codes is not intended to... the data supporting the petition, EPA has modified the levels at which tolerances are being...

76 FR 55807 - Novaluron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

.../Exposure Analysis Modeling System (PRZM/EXAMS) for parent novaluron in surface water; and the Screening... listed in this unit could also be affected. The North American Industrial Classification System (NAICS... supporting the petition, EPA has revised the tolerances for sweet corn forage and determined it is not...

77 FR 18748 - Dicloran and Formetanate; Proposed Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... Dicloran and Formetanate; Proposed Tolerance Actions AGENCY: Environmental Protection Agency (EPA). ACTION... . SUPPLEMENTARY INFORMATION: I. General Information A. Does this action apply to me? You may be potentially affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer...

77 FR 75560 - Chlorantraniliprole; Pesticide Tolerances, Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... incorrectly established tolerances for ``Vegetable, foliage of legume, group 7, forage'' and ``Vegetable, foliage of legume, group 7, hay''. Under EPA's crop group regulation there are no such crop groups. Rather, there is only a crop group for ``Vegetable, foliage of legume, group 7.'' The petition correctly...

77 FR 18710 - Acetamiprid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... System (NAICS) codes have been provided to assist you and others in determining whether this action might.... Based upon review of the data supporting the petitions, EPA has revised the tolerance associated with... exposures for which there is reliable information.'' This includes exposure through drinking water and in...

77 FR 3617 - Etoxazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... affected. The North American Industrial Classification System (NAICS) codes have been provided to assist... the data supporting the petition, EPA has modified the levels at which some of the tolerances are... drinking water and in residential settings, but does not include occupational exposure. Section 408(b)(2)(C...

75 FR 70143 - Acequinocyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

.../water/index.htm . Based on the Pesticide Root Zone Model/Exposure Analysis Modeling System (PRZM/EXAMS... be affected. The North American Industrial Classification System (NAICS) codes have been provided to... the data supporting the petition, EPA has revised the proposed tolerance for hop dried cones from 3.5...

78 FR 40017 - Ethalfluralin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

.... The following list of North American Industrial Classification System (NAICS) codes is not intended to... filing. Based upon review of the data supporting the petition, EPA has revised the tolerance expression... drinking water and in residential settings, but does not include occupational exposure. Section 408(b)(2)(C...

78 FR 30213 - 1-Naphthaleneacetic acid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... Industrial Classification System (NAICS) codes is not intended to be exhaustive, but rather provides a guide... filing. Based upon review of the data supporting the petition, EPA has revised the proposed tolerance on... for which there is reliable information.'' This includes exposure through drinking water and in...

78 FR 40027 - Novaluron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... chromatography/ultraviolet (HPLC/UV) method) are available to enforce the tolerance expression. The method may be... available at http://www.regulations.gov or at the Office of Pesticide Programs Regulatory Public Docket (OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER...

78 FR 67048 - Prothioconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... code 111). Animal production (NAICS code 112). Food manufacturing (NAICS code 311). Pesticide manufacturing (NAICS code 32532). B. How can I get electronic access to other related information? You may... Assessment and Determination of Safety Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance...

40 CFR 180.571 - Mesotrione; tolerances for residues.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the herbicide mesotrione, including its metabolites and degradates, in or on the commodities in the... residues of the herbicide mesotrione, 2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione, in connection with use of the herbicide under section 18 emergency exemptions granted by EPA. The tolerances are...

77 FR 56782 - Bifenthrin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

..., hay. Interregional Research Project Number 4 (IR-4) requested these tolerances under the Federal Food... OCSPP test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and Guidelines.'' C. How can I file an objection or hearing request? Under...

78 FR 55635 - Prometryn; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-11

.... Interregional Research Project Number 4 (IR-4) requested these tolerances under the Federal Food, Drug, and... test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and Guidelines. C. How can I file an objection or hearing request? Under FFDCA...

75 FR 60327 - Fluoxastrobin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ``ensure that there is a reasonable certainty that no harm will result to infants and children... studies to human risk. EPA has also considered available information concerning the variability of the...

40 CFR 180.2010 - Threshold of regulation determinations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Threshold of regulation determinations... Requiring a Tolerance or an Exemption From a Tolerance § 180.2010 Threshold of regulation determinations... on EPA's determination that the uses are below the threshold of regulation. Pesticide Chemical CAS...

40 CFR 180.2010 - Threshold of regulation determinations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Threshold of regulation determinations... Requiring a Tolerance or an Exemption From a Tolerance § 180.2010 Threshold of regulation determinations... on EPA's determination that the uses are below the threshold of regulation. Pesticide Chemical CAS...

40 CFR 180.2010 - Threshold of regulation determinations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Threshold of regulation determinations... Requiring a Tolerance or an Exemption From a Tolerance § 180.2010 Threshold of regulation determinations... on EPA's determination that the uses are below the threshold of regulation. Pesticide Chemical CAS...

Effect of culture condition on the growth, biochemical composition and EPA production of alkaliphilic Nitzschia plea isolated in the Southeast of China.

PubMed

Zhang, Dongmei; Wen, Shumei; Wu, Xia; Cong, Wei

2018-06-01

To overcome the contamination in open pond, microalgal strain selection should focus on species with tolerability to extreme environments. In this study, a native alkaliphilic algae, diatom Nitzschia plea was obtained in Southeast of China, which could tolerate high concentration of NaHCO 3 (0.15 mol/L) and high pH (> 10). The effects of initial pH, light intensity and temperature on cell growth, biochemical composition and fatty acid profile of N. plea were investigated. Results indicated its specific growth rate could reach 1.2 day -1 , lipid content was in the range 14.6-30.2% of dry weight, eicosapntemacnioc acid (EPA, C20:5) accounted for around 15% of total fatty acids. Alkalic condition benefited for both cell growth and EPA synthesis. Appropriately increasing light intensity and temperature could improve cell growth rate and lipid synthesis, although the proportion of EPA in total fatty acids decreased slightly. The optimal culture condition (pH 9.00, temperature 35.0 °C, light intensity 158.6 µmol/m 2 s) was suggested for maximum yield of EPA based on the response surface model. The overall biomass productivity and EPA productivity were 0.301 g/L/day and 7.43 mg/L/day, respectively. In conclusion, alkalic environment was helpful for the steady operation of open pond cultivation of N. plea with the characteristics of fast growth rate and high EPA content, which exhibited its commercial value.

EnviroAtlas -Durham, NC- One Meter Resolution Urban Area Land Cover Map (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas ). The EnviroAtlas Durham, NC land cover map was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from July 2010 at 1 m spatial resolution. Five land cover classes were mapped: impervious surface, soil and barren, grass and herbaceous, trees and forest, and water. An accuracy assessment using a stratified random sampling of 500 samples yielded an overall accuracy of 83 percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Durham, and includes the cities of Durham, Chapel Hill, Carrboro and Hillsborough, NC. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas ) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets ).

EnviroAtlas -Milwaukee, WI- One Meter Resolution Urban Land Cover Data (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The EnviroAtlas Milwaukee, WI land cover data and map were generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from Late Summer 2010 at 1 m spatial resolution. Nine land cover classes were mapped: water, impervious surfaces (dark and light), soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, agriculture, and wetlands (woody and emergent). An accuracy assessment using a completely random sampling of 600 samples yielded an overall accuracy of 85.39% percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Milwaukee. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-

EnviroAtlas -- Woodbine, IA -- One Meter Resolution Urban Land Cover Data (2011) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The EnviroAtlas Woodbine, IA land cover (LC) data and map were generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from Late Summer 2011 at 1 m spatial resolution. Six land cover classes were mapped: water, impervious surfaces (dark and light), soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, and agriculture. An accuracy assessment using a completely random sampling of 600 samples yielded an overall accuracy of 87.03% percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Woodbine. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

EnviroAtlas -Portland, ME- One Meter Resolution Urban Land Cover (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The Portland, ME land cover map was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from Late Summer 2010 at 1 m spatial resolution. Nine land cover classes were mapped: water, impervious surfaces (dark and light), soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, agriculture, and wetlands (woody and emergent). An accuracy assessment using a stratified random sampling of 600 samples yielded an overall accuracy of 87.5 percent using a minimum mapping unit of 9 pixels (3x3 pixel window). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Portland.This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

75 FR 29431 - Coat Protein of Plum Pox Virus; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-26

... (EPA). ACTION: Final rule. SUMMARY: This regulation establishes an exemption from the requirement of a... SUPPLEMENTARY INFORMATION). ADDRESSES: EPA has established a docket for this action under docket identification... A. Does this Action Apply to Me? You may be potentially affected by this action if you are an...

Using the time-to-event continual reassessment method in the presence of partial orders

PubMed Central

Wages, Nolan A.; Conaway, Mark R.; O'Quigley, John

2012-01-01

The time-to-event continual reassessment method (TITE-CRM) was proposed to handle the problem of long trial duration in Phase 1 trials as a result of late-onset toxicities. Here, we implement the TITE-CRM in dose–finding trials of combinations of agents. When studying multiple agents, monotonicity of the dose-toxicity curve is not clearly defined. Therefore, the toxicity probabilities follow a partial order, meaning that there are pairs of treatments for which the ordering of the toxicity probabilities is not known at the start of the trial. A CRM design for partially ordered trials (PO-CRM) was recently proposed. Simulation studies show that extending the TITE-CRM to the partial order setting produces results similar to those of the PO-CRM in terms of maximum tolerated dose recommendation yet reduces the duration of the trial. PMID:22806898

77 FR 47296 - Flutriafol; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

... objections and hearing requests are provided in 40 CFR 178.25(b). In addition to filing an objection or.... Tolerances were previously established on November 9, 2011 for banana, grape, raisin; pome and stone fruit... Imported Bananas,'' at p. 40 in docket ID number EPA-HQ-OPP-2010-0875. [[Page 47298

75 FR 35653 - Thiamethoxam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2009-0737; FRL-8830-4] Thiamethoxam... regulation establishes tolerances for residues of thiamethoxam in or on onion, dry bulb. Syngenta Crop... thiamethoxam (3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-methyl-N-nitro-4H-1,3,5- oxadiazin-4-imine) and its...

75 FR 8261 - Flumioxazin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Classification System (NAICS) codes have been provided to assist you and others in determining whether this... supporting the petition, EPA has revised the proposed tolerance on hop, dried cones. The reason for this... drinking water and in residential settings, but does not include occupational exposure. Section 408(b)(2)(C...

Tolerance to anatoxin-a and nicotine on operant behavior: A search for mechanisms.

EPA Science Inventory

Anatoxin-a is a cyanobacterial toxin of concern to EPA as it can contaminate water supplies and poison a wide variety of species by stimulating nicotinic receptors. Research has shown tolerance to the effects of (+)anatoxin-a and nicotine on operant behavior with weekly administr...

76 FR 69662 - Methacrylic Polymer; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... part of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed...

75 FR 16017 - Cloquintocet-mexyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

...-quinolinoxyacetic acid) on wheat forage, wheat grain, wheat hay, and wheat straw. Arysta LifeScience North America...-5805. II. Petition for Tolerance EPA has received a petition from Arysta LifeScience North America, LLC... filing of the above-referenced pesticide petition (PP 9E7592) by Arysta LifeScience North America, LLC...

77 FR 41346 - Trinexapac-ethyl; Proposed Pesticide Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

.... SUMMARY: This document proposes to amend the existing trinexapac-ethyl tolerance levels for wheat, forage and wheat, middlings as well as change the commodity definition for hog, kidney. Additionally the EPA..., molasses; and wheat, bran under the Federal Food, Drug, and Cosmetic Act (FFDCA). DATES: Comments must be...

77 FR 45535 - Aldicarb; Proposed Tolerance Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... Aldicarb; Proposed Tolerance Actions AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule... Information A. Does this action apply to me? You may be potentially affected by this action if you are an... exhaustive, but rather provides a guide for readers regarding entities likely to be affected by this action...

Antibiosis and tolerance discovered in USDA-ARS sorghums resistant to the sugarcane aphid Melanaphis sacchari (Hemiptera: Aphididae)

USDA-ARS?s Scientific Manuscript database

The sugarcane aphid, Melanaphis sacchari, was discovered infesting grain sorghum near Beaumont, TX, close to the Texas and Louisiana state line a few miles inland from the Gulf coast in the late summer of 2013, and has been a perennial pest of sorghum through 2016. Our research was aimed at identif...

Registration of sorghum germplasm Tx3408 and Tx3409 with tolerance to sugarcane aphid [Melanaphis saccari (Zehntner)

USDA-ARS?s Scientific Manuscript database

The sorghum (Sorghum bicolor L. Moench) germplasm lines Tx3408 and Tx3409 were developed and released from Texas A&M AgriLife Research and the USDA-ARS in 2015. Both of these lines were developed from intentional crosses using the pedigree method of plant breeding. The breeding crosses for these l...

EnviroAtlas -- Memphis, TN (2012) -- One Meter Resolution Urban Land Cover Data

EPA Pesticide Factsheets

The Memphis, TN EnviroAtlas One Meter-scale Urban Land Cover (MULC) dataset comprises 2,733 km2 around the city of Memphis, surrounding towns, and rural areas. These leaf-on LC data and maps were derived from 1-m pixel, four-band (red, green, blue, and near-infrared) aerial photography acquired from the United States Department of Agriculture (USDA) National Agriculture Imagery Program (NAIP) on four dates in 2012: June 15, June 18, June 21 and June 23, and one date in 2013: July 12. Three separate LiDAR (Light Detection and Ranging) data sets collected on February 19, 2009 00e2?? August 2, 2010, December 1-2, 2011 and January 23-24, 2012 were integrated for Shelby Co., TN, Crittenden Co., AR, and DeSoto Co, MS. Five MULC classes were mapped directly from the NAIP and LiDAR data: Water, Impervious, Soil, Trees, and Grass/Herbaceous. Agriculture was derived from USDA Common Land Unit (CLU) data. Woody and emergent wetlands were copied from existing National Wetlands Inventory (NWI) data. Analysis of a random sampling of 612 photo-interpreted land cover reference points yielded an overall users accuracy of 86.9%. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as do

77 FR 68692 - 1,4-Dimethylnaphthalene; Amendment to an Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... across the treatment and control groups and average fetal weights were unaffected. No structural... expanding the current exemption to include all sprouting root and tuber vegetables (EPA Crop Group 01) and all bulb vegetables (EPA Crop Group 03). On behalf of D-I-1-4, Inc., a division of 1,4Group, Inc...

An appraisal of the classic forest succession paradigm with the shade tolerance index.

PubMed

Lienard, Jean; Florescu, Ionut; Strigul, Nikolay

2015-01-01

In this paper we revisit the classic theory of forest succession that relates shade tolerance and species replacement and assess its validity to understand patch-mosaic patterns of forested ecosystems of the USA. We introduce a macroscopic parameter called the "shade tolerance index" and compare it to the classic continuum index in southern Wisconsin forests. We exemplify shade tolerance driven succession in White Pine-Eastern Hemlock forests using computer simulations and analyzing approximated chronosequence data from the USDA FIA forest inventory. We describe this parameter across the last 50 years in the ecoregions of mainland USA, and demonstrate that it does not correlate with the usual macroscopic characteristics of stand age, biomass, basal area, and biodiversity measures. We characterize the dynamics of shade tolerance index using transition matrices and delimit geographical areas based on the relevance of shade tolerance to explain forest succession. We conclude that shade tolerance driven succession is linked to climatic variables and can be considered as a primary driving factor of forest dynamics mostly in central-north and northeastern areas in the USA. Overall, the shade tolerance index constitutes a new quantitative approach that can be used to understand and predict succession of forested ecosystems and biogeographic patterns.

77 FR 66721 - Metconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... information in support of this action. EPA has sufficient data to assess the hazards of and to make a... tolerance shows that there will be no increase in the maximum reasonably balanced dietary burden for beef cattle, swine, or poultry but a small increase for diary cattle. There is no increase for beef cattle...

77 FR 2910 - Bacillus Amyloliquefaciens Strain D747; Exemption From the Requirement of a Tolerance; Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2010-0944; FRL-9334-3] Bacillus... requirement of a tolerance for residues of Bacillus amyloliquefaciens strain D747 (formerly known as Bacillus subtilis variant amyloliquefaciens strain D747). This document is being issued to correct the typographical...

75 FR 44917 - Castor Oil, Ethoxylated, Dioleate; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-30

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in...

78 FR 20032 - Styrene-Ethylene-Propylene Block Copolymer; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-03

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... integral part of its composition, the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed...

76 FR 77709 - Butyl acrylate-methacrylic acid-styrene polymer; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... integral part of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed...

PRN 2007-2: Guidance on Small-Scale Field Testing and Low-level Presence in Food of Plant-Incorporated Protectants (PIPs)

EPA Pesticide Factsheets

This notice clarifies how EPA ensures the safety of residues of PIPs possibly present in food or feed and when a tolerance or tolerance exemption would be required for field tests for biotechnology-derived food and feed crop plants containing PIPs.

76 FR 82152 - Cyhalofop-butyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

... original long-term studies were approaching a maximum tolerated dose. In addition, there were no positive....regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One..., identified by docket ID number EPA-HQ-OPP-2011-0283, by one of the following methods: Federal eRulemaking...

77 FR 28266 - Acetone; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... consideration to exposure of infants and children to the pesticide chemical residue in establishing a tolerance and to ``ensure that there is a reasonable certainty that no harm will result to infants and children... the results of the studies to human risk. EPA has also considered available information concerning the...

EnviroAtlas -Phoenix, AZ- One Meter Resolution Urban Land Cover Data (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The EnviroAtlas Phoenix, AZ land cover data and map were generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near-infrared) aerial photography taken from June through September, 2010 at 1 m spatial resolution. Seven land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, shrubland, grass and herbaceous non-woody vegetation, and agriculture. An accuracy assessment using a completely random sampling of 598 land cover reference points yielded an overall accuracy of 69.2%. The area mapped includes the entirety of the Central Arizona-Phoenix Long-Term Ecological Research (CAP-LTER) area, which was classified by the Environmental Remote Sensing and Geoinformatics Lab (ERSG) at Arizona State University. The land cover dataset also includes an area of approximately 625 square kilometers which is located north of Phoenix. This section was classified by the EPA land cover classification team. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data

EnviroAtlas - Phoenix, AZ - One Meter Resolution Urban Land Cover Data (2010)

EPA Pesticide Factsheets

The EnviroAtlas Phoenix, AZ land cover (LC) data and map were generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near-infrared) aerial photography taken from June through September, 2010 at 1 m spatial resolution. Seven land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, shrubs, grass and herbaceous non-woody vegetation, and agriculture. An accuracy assessment using a completely random sampling of 598 land cover reference points yielded an overall accuracy of 69.2%. The area mapped includes the entirety of the Central Arizona-Phoenix Long-Term Ecological Research (CAP-LTER) area, which was classified by the Environmental Remote Sensing and Geoinformatics Lab (ERSG) at Arizona State University. The land cover dataset also includes an area of approximately 625 square kilometers which is located north of Phoenix. This section was classified by the EPA land cover classification team. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each at

Genetic Linkage Mapping of Genomic Regions Conferring Tolerance to High Aluminum in Slash Pine

Treesearch

Thomas L. Kubisiak; C. Dana Nelson; J. Nowak; A.L. Friend

2000-01-01

Reports of reduced growth and vigor of forest trees in Europe and North America have been accumulating in recent years. In eastern North America, increased mortality and reduced radial growth rates have been noted for red spruce, frasier fir, and sugar maple. USDA Forest Service inventory data from permanent survey plots has revealed an unexpected reduction of radial...

Freeze injury to southern pine seedlings

Treesearch

David B. South

2006-01-01

Freeze injury to roots and shoots of pines is affected by genotype and nursery practices. Local sources of shortleaf pine and Virginia pine that are grown in nurseries in USDA hardiness Zones 6 and 7a are relatively freeze tolerant. However, loblolly pine, slash pine, and longleaf pine seedlings have been injured by a number of freeze events (0 to 24 °F) in hardiness...

Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia.

PubMed

Minami, Asako; Ishimura, Noriko; Sakamoto, Sadaichi; Takishita, Eiko; Mawatari, Kazuaki; Okada, Kazuko; Nakaya, Yutaka

2002-02-01

The purpose of the present study was to test whether hyperlipidaemia and insulin resistance in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be improved by dietary supplementation with purified eicosapentaenoic acid (EPA) or oleic acid (OA). Male OLETF rats were fed powdered chow (510 g fat/kg) alone (n 8) or chow supplemented with 10 g EPA- (n 8) or OA- (n 8) rich oil/kg per d from 5 weeks until 30 weeks of age. An oral glucose tolerance test and hyperinsulinaemic euglycaemic clamp was performed at 25 and 30 weeks of age. EPA supplementation resulted in significantly (P<0.05) reduced plasma lipids, hepatic triacylglycerols, and abdominal fat deposits, and more efficient in vivo glucose disposal compared with OA supplementation and no supplementation. OA supplementation was associated with significantly increased insulin response to oral glucose compared with EPA supplementation and no supplementation. Inverse correlation was noted between glucose uptake and plasma triacylglycerol levels (r -086, P<0.001) and abdominal fat volume (r -0.80, P<0.001). The result of oral glucose tolerance test study showed that the rats fed EPA tended to improve glucose intolerance, although this was not statistically significant. Levels of plasma insulin at 60 min after glucose was significantly increased in rats fed OA compared with the other two groups. The results indicate that long-term feeding of EPA might be effective in preventing insulin resistance in diabetes-prone rats, at least in part, due to improving hypertriacylglycerolaemia.

40 CFR 180.448 - Hexythiazox; tolerance for residues.

Code of Federal Regulations, 2012 CFR

2012-07-01

.../revocation date Corn, sweet, plus cobs with husks removed (K+CWHR) 0.02 12/31/12 Corn, sweet, forage 6.0 12... (EPA Regions 7-12 only) 4.0 Corn, sweet, kernel plus cob with husks removed (EPA Regions 7-12 only) 0.1... 24 Corn, field, forage 3.0 Corn, field, grain 0.02 Corn, field, stover 7.0 Date, dried fruit 1.0...

POPULATION GENETICS AND TOLERANCE TO DIOXIN-LIKE COMPOUNDS OF A MIGRATORY MARINE FISH (MENIDIA MENIDIA) IN POLYCHLORINATED BIPHENOL-CONTAMINTED AND REFERENCES SITES

EPA Science Inventory

We evaluated a population of migratory fish (Menidia menidia) that spawn in New Bedford Harbor (NBH), MA, USA, a U.S. EPA Superfund site with extreme polychlorinated biphenyl (PCB) for evidence of pollution tolerance and population genetic changes. We selected this site because ...

78 FR 57276 - Quinoxyfen; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-18

... or on grape; pepper, bell; pepper, nonbell; and strawberry as they will be superseded by crop group... grape at 0.60 ppm; strawberry at 0.90 ppm; pepper, bell at 0.35 ppm; and pepper, nonbell at 1.7 ppm, as..., strawberries, and peppers. EPA is raising the level of the requested U.S. tolerances for residues of quinoxyfen...

78 FR 78727 - Copper Sulfate Pentahydrate; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

.... If EPA is able to determine that a finite tolerance is not necessary to ensure that there is a... ubiquitous in nature and is a necessary nutritional element for both animals (including humans) and plants... natural ore. It is one of the elements found essential to life. The National Academy of Science...

78 FR 7275 - 2-Pyrrolidone, 1-Ethenyl-, Polymer With Ethenol; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... integral part of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed...

77 FR 65834 - Residues of Fatty Acids, Tall-Oil, Ethoxylated Propoxylated; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

... in residential settings. If EPA is able to determine that a finite tolerance is not necessary to... integral part of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed...

78 FR 55644 - Styrene, Copolymers with Acrylic Acid and/or Methacrylic Acid; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-11

... in residential settings. If EPA is able to determine that a finite tolerance is not necessary to... composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d...

78 FR 6213 - Styrene-2-Ethylhexyl Acrylate Copolymer; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

.... If EPA is able to determine that a finite tolerance is not necessary to ensure that there is a... composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d...

77 FR 65831 - Polymers; exemptions from the requirement of a tolerance.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d...

75 FR 52269 - Acetic Acid Ethenyl Ester, Polymer With Oxirane; Tolerance Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... contain as an integral part of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other...

40 CFR 180.448 - Hexythiazox; tolerance for residues.

Code of Federal Regulations, 2011 CFR

2011-07-01

.../revocation date Corn, field, forage 2.0 12/31/10 Corn, field, grain 0.05 12/31/10 Corn, field, stover 2.0 12/31/10 Corn, sweet, plus cobs with husks removed (K+CWHR) 0.02 12/31/12 Corn, sweet, forage 6.0 12/31... (EPA Regions 7-12 only) 4.0 Corn, sweet, kernel plus cob with husks removed (EPA Regions 7-12 only) 0.1...

77 FR 73951 - Pyriproxyfen; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-12

... 1998 Continuing Survey of Food Intake by Individuals (CSFII). As to residue levels in food, EPA assumed... outdoor applications). Formulations include carpet powders, foggers, aerosol sprays, liquids (shampoos...

An Appraisal of the Classic Forest Succession Paradigm with the Shade Tolerance Index

PubMed Central

Lienard, Jean; Florescu, Ionut; Strigul, Nikolay

2015-01-01

In this paper we revisit the classic theory of forest succession that relates shade tolerance and species replacement and assess its validity to understand patch-mosaic patterns of forested ecosystems of the USA. We introduce a macroscopic parameter called the “shade tolerance index” and compare it to the classic continuum index in southern Wisconsin forests. We exemplify shade tolerance driven succession in White Pine-Eastern Hemlock forests using computer simulations and analyzing approximated chronosequence data from the USDA FIA forest inventory. We describe this parameter across the last 50 years in the ecoregions of mainland USA, and demonstrate that it does not correlate with the usual macroscopic characteristics of stand age, biomass, basal area, and biodiversity measures. We characterize the dynamics of shade tolerance index using transition matrices and delimit geographical areas based on the relevance of shade tolerance to explain forest succession. We conclude that shade tolerance driven succession is linked to climatic variables and can be considered as a primary driving factor of forest dynamics mostly in central-north and northeastern areas in the USA. Overall, the shade tolerance index constitutes a new quantitative approach that can be used to understand and predict succession of forested ecosystems and biogeographic patterns. PMID:25658092

77 FR 50617 - Pesticide Tolerance Crop Grouping Program III; Revisions to General Tolerance Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... promulgated under section 408(e)(1)(C) which authorizes EPA to establish ``general procedures and requirements to implement [section 408].'' 21 U.S.C. 346a(e)(1)(C). C. Does this action apply to me? You may be.... Potentially affected entities may include, but are not limited to: Crop production (NAICS code 111), e.g...

76 FR 55814 - 2,4-D; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 180 [EPA-HQ-OPP-2010-0905; FRL-8881-7] 2,4-D... regulation establishes tolerances for residues of 2,4-D in or on teff, bran; teff, forage; teff, grain; and... 408(d)(3) of FFDCA, 21 U.S.C. 346a(d)(3), announcing the filing of a pesticide petition (PP 0F7796) by...

EnviroAtlas -Tampa, FL- One Meter Resolution Urban Land Cover (2010)

EPA Pesticide Factsheets

The EnviroAtlas Tampa, FL land cover map was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial photography from April-May 2010 at 1 m spatial resolution. Eight land cover classes were mapped: impervious surface, soil and barren, grass and herbaceous, trees and forest, water, agriculture, woody wetland, and emergent wetland. The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Tampa, and includes the cities of Clearwater and St. Petersburg, as well as additional out-lying areas. An accuracy assessment using a stratified random sampling of 600 samples (100 per class) yielded an overall accuracy of 70.67 percent and an area weighted accuracy of 81.87 percent using a minimum mapping unit of 9 pixels (3x3 pixel window). This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).

Updated Human Health Risk Analyses for Chlorpyrifos

EPA Pesticide Factsheets

EPA has revised the human health hazard assessment and drinking water exposure assessment for chlorpyrifos that supported our October 2015 proposal to revoke all food residue tolerances for chlorpyrifos.

Production of long chain omega-3 fatty acids and carotenoids in tropical areas by a new heat-tolerant microalga Tetraselmis sp. DS3.

PubMed

Tsai, Hsin-Pei; Chuang, Lu-Te; Chen, Ching-Nen Nathan

2016-02-01

Demand for long chain ω-3 fatty acids from non-fish source for vegetarians has increased recently. Marine microalgae are the primary producers of EPA/DHA and promising alternatives for fish oil. Tropical areas have abundant sunlight throughout the year for microalgal cultivation but this practice can be hindered by high temperature. Discovery of heat-tolerant marine microalgae that can synthesize EPA/DHA will solve these problems. A new species of microalga was isolated from a high temperature lagoon and identified as Tetraselmis sp. DS3. These cells could grow at 40 °C, the highest temperature for marine microalgal growth ever reported. Its ω-3 fatty acids and EPA accounted for 33 and 10% of total lipids, respectively, grown in nitrogen-depleted conditions. These cells also accumulated more than 5% β-carotene and 0.48% lutein in biomass. This new microalga can be cultivated for long chain ω-3 fatty acids and lutein production in the tropical areas. Copyright © 2015 Elsevier Ltd. All rights reserved.

Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia.

PubMed

Hull, Mark A

2013-01-01

The strong link between inflammation and colorectal carcinogenesis provides the rationale for using anti-inflammatory agents for chemoprevention of colorectal cancer (CRC). Several naturally occurring substances with anti-inflammatory properties, used in a purified 'nutraceutical' form, including omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and polyphenols such as curcumin and resveratrol, have been demonstrated to have anti-CRC activity in preclinical models. As expected, these agents have an excellent safety and tolerability profile in Phase II clinical trials. Phase III randomized clinical trials of these naturally occurring substances are now beginning to be reported. The omega-3 polyunsaturated fatty acid EPA, in the free fatty acid (FFA) form, has been demonstrated to reduce adenomatous polyp number and size in patients with familial adenomatous polyposis (FAP), a finding which has prompted evaluation of this formulation of EPA for prevention of 'sporadic' colorectal neoplasia. Anti-inflammatory 'nutraceuticals' require further clinical evaluation in polyp prevention trials as they exhibit many of the characteristics of the ideal cancer chemoprevention agent, including safety, tolerability and patient acceptability.

Identifying a maximum tolerated contour in two-dimensional dose-finding

PubMed Central

Wages, Nolan A.

2016-01-01

The majority of Phase I methods for multi-agent trials have focused on identifying a single maximum tolerated dose combination (MTDC) among those being investigated. Some published methods in the area have been based on the notion that there is no unique MTDC, and that the set of dose combinations with acceptable toxicity forms an equivalence contour in two dimensions. Therefore, it may be of interest to find multiple MTDC's for further testing for efficacy in a Phase II setting. In this paper, we present a new dose-finding method that extends the continual reassessment method to account for the location of multiple MTDC's. Operating characteristics are demonstrated through simulation studies, and are compared to existing methodology. Some brief discussion of implementation and available software is also provided. PMID:26910586

Freezing induces a loss of freeze tolerance in an overwintering insect.

PubMed

Brown, C L; Bale, J S; Walters, K F A

2004-07-22

Cold-hardy insects overwinter by one of two main strategies: freeze tolerance and freeze avoidance by supercooling. As a general model, many freeze-tolerant species overwinter in extreme climates, freeze above -10 degrees C via induction by ice-nucleating agents, and once frozen, can survive at temperatures of up to 40 degrees C or more below the initial freezing temperature or supercooling point (SCP). It has been assumed that the SCP of freeze-tolerant insects is unaffected by the freezing process and that the freeze-tolerant state is therefore retained in winter though successive freeze-thaw cycles of the body tissues and fluids. Studies on the freeze-tolerant larva of the hoverfly Syrphus ribesii reveal this assumption to be untrue. When a sample with a mean 'first freeze' SCP of -7.6 degrees C (range of -5 degrees C to -9.5 degrees C) were cooled, either to -10 degrees C or to their individual SCP, on five occasions, the mean SCP was significantly depressed, with some larvae subsequently freezing as low as -28 degrees C. Only larvae that froze at the same consistently high temperature above -10 degrees C were alive after being frozen five times. The wider occurrence of this phenomenon would require a fundamental reassessment of the dynamics and distinctions of the freeze-tolerant and freeze-avoiding strategies of insect overwintering. Copyright 2004 The Royal Society

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.

The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility at the northeastern edge of the city of Hanover, Kansas, from 1950 until the early 1970s. During this time, commercial grain fumigants containing carbon tetrachloride were in common use by the grain storage industry to preserve grain in their facilities. In February 1998, trace to low levels of carbon tetrachloride were detected in two private lawn and garden wells near the former grain storage facility at Hanover, as part of a statewide USDA private well sampling program that was implemented bymore » the Kansas Department of Health and Environment (KDHE) near former CCC/USDA facilities. In July 2007, the CCC/USDA sampled indoor air at nine residences on or adjacent to its former facility to address the residents concerns. Low levels of carbon tetrachloride were detected at four of the nine homes. Consequently, the CCC/USDA has conducted investigations, under the direction of the KDHE, to determine the source and extent of the carbon tetrachloride contamination that might be associated with the former facility. In July 2007, the CCC/USDA sampled indoor air at nine residences on or adjacent to its former facility to address the residents concerns regarding vapor intrusion (VI). Low levels of carbon tetrachloride were detected at four of the nine homes. Because carbon tetrachloride found in private wells and indoor air at Hanover might be linked to historical use of fumigants containing carbon tetrachloride at its former grain storage facility, the CCC/USDA has conducted investigations to determine the source and extent of the carbon tetrachloride contamination that may be associated with the former facility. The results of the comprehensive investigation at Hanover indicate that no unacceptable risk to human health currently exists from exposure to surface and subsurface soils by either ingestion, inhalation or dermal contact. No risk is associated with potential exposure to contaminated groundwater at Hanover. No drinking water wells are known to exist in Hanover, and the drinking water supply comes from RWD No.1 at Lanham, Kansas, located 6.5 mi north of Hanover. Limited potential risk was identified due to exposure to indoor air contaminated with carbon tetrachloride, but this risk has been mitigated, thereby removing this threat to human health. Radon is prevalent in the community, at concentrations exceeding the level at which the EPA recommends additional measures (testing and/or mitigation). The recommended testing and mitigation (if needed) are the responsibility of the homeowners. In the current condition in which no private wells are used for drinking water in the affected area, no unacceptable human health risk from carbon tetrachloride is associated with the identified impacted media at the Hanover site.« less

78 FR 20029 - Castor Oil, Polymer With Adipic Acid, Linoleic Acid, Oleic Acid and Ricinoleic Acid; Tolerance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-03

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... environment. 2. The polymer does contain as an integral part of its composition the atomic elements carbon... impurities, any element other than those listed in 40 CFR 723.250(d)(2)(ii). 4. The polymer is neither...

Risk assessment of dioxins and dioxin-like PCBs in food--comments by the German Federal Environmental Agency.

PubMed

Gies, Andreas; Neumeier, Günther; Rappolder, Marianne; Konietzka, Rainer

2007-04-01

Human health risk assessments for dioxins and dioxin-like PCBs (with the exception of the one by US-EPA) recommend health based exposure limits within the range of 1-4 pg WHO-TEQ/kg bw per day. As all humans are exposed to measurable levels of dioxins and related substances, the determination of the tolerated daily intake is a very significant decision and may influence limit values guiding risk reduction measures and target levels. The proposed TDI has to protect all human subpopulations. In the case of dioxin this is particularly important as the exposure of infants through breast-feeding may exceed the exposure of adults by one or two orders of magnitude. An overview of recently recommended limit values (WHO, SCF, JECFA) for PCDDs, PCDFs and dioxin-like PCBs using WHO-TEFs shows the common feature that the values were derived only from non carcinogenic endpoints. In November 2000 the Scientific Committee on Food of the European Commission published an 'Opinion of the SCF on the Risk Assessment of Dioxins and Dioxin-like PCBs in Food' [SCF, Scientific Committee on Food 2000. Opinion of the SCF on the risk assessment of dioxins and dioxin-like PCBs in food. European Commission, Brussels, Adopted on November 2000 http://europa.eu.int/comm/food/fs/sc/scf/out78_en.pdf]. On the basis of this extensive review of data and experimental results the Committee recommended a temporary tolerable weekly intake (t-TWI) of 7 pg WHO-TEQ/kg bw. Only six months later the SCF carried out a re-evaluation of its t-TWI from November 2000. The reconsideration of 'pivotal studies' led to the situation that the re-assessment is now based only on rat studies which investigated only reproductive effects only on male offspring and, in addition, three of these studies are single dose studies at gestational day 15. Applying an overall uncertainty factor of 10 to the LOAEL derived estimated human daily intakes (EHDI) the SCF concluded that 14 pg/kg bw per week should be considered as a tolerable intake for 2,3,7,8-TCDD. The SCF stated that on a body weight basis, the dioxin intake of breast-fed infants has been estimated to be one to two orders of magnitude higher than the average adult intake. Recent German data suggest that the body burden of formerly breast-fed children aged 9-11 is still about 30% higher than those of their formula-fed age-mates. As breast-feeding has measurable benefits for neurological and immunological development, formula feeding cannot be recommended as an alternative to lower dioxin intake. So the only remaining way to lower the dioxin uptake is to drastically reduce the background exposure of the general population. It is acknowledged that any recommendation of a precise number for a TDI is flawed by uncertainties and the possibility of different weight being given to the studies of relevance. The determination of the TDI has influence on all regulatory limit values that are based on the TDI value. A higher TDI lowers the level of protection for humans. It is proposed by the German Federal Environmental Agency that the TDI should be reassessed in a process transparent to the public and on the basis of all relevant endpoints from animal experiments and human epidemiology, including the assessment of cancer risks.

Food and Feed Commodity Vocabulary

EPA Pesticide Factsheets

Food and Feed Vocabulary was developed to consolidate all the major OPP Commodity Vocabularies into one standardized vocabulary. The EPA-preferred term is the only term that can be used in setting tolerances.

Final corrective action study for the former CCC/USDA facility in Ramona, Kansas.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.

Past operations at a grain storage facility formerly leased and operated by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) in Ramona, Kansas, resulted in low concentrations of carbon tetrachloride in groundwater that slightly exceed the regulatory standard in only one location. As requested by the Kansas Department of Health and Environment, the CCC/USDA has prepared a Corrective Action Study (CAS) for the facility. The CAS examines corrective actions to address groundwater impacted by the former CCC/USDA facility but not releases caused by other potential groundwater contamination sources in Ramona. Four remedial alternatives were considered in themore » CAS. The recommended remedial alternative in the CAS consists of Environmental Use Control to prevent the inadvertent use of groundwater as a water supply source, coupled with groundwater monitoring to verify the continued natural improvement in groundwater quality. The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) has directed Argonne National Laboratory to prepare a Corrective Action Study (CAS), consistent with guidance from the Kansas Department of Health and Environment (KDHE 2001a), for the CCC/USDA grain storage facility formerly located in Ramona, Kansas. This effort is pursuant to a KDHE (2007a) request. Although carbon tetrachloride levels at the Ramona site are low, they remain above the Kansas Tier 2 risk-based screening level (RBSL) and the U.S. Environmental Protection Agency (EPA) maximum contaminant level (MCL) of 5 {micro}g/L (Kansas 2003, 2004). In its request for the CAS, the KDHE (2007a) stated that, because of these levels, risk is associated with potential future exposure to contaminated groundwater. The KDHE therefore determined that additional measures are warranted to limit future use of the property and/or exposure to contaminated media as part of site closure. The KDHE further requested comparison of at least two corrective action alternatives to the 'no-action' alternative, as the basis for the Draft Corrective Action Decision for the site. The history and nature of the contamination and previous investigations are summarized in Section 2. Also included in Section 2 is an evaluation of human and environmental targets and potential exposure pathways. Section 3 describes the corrective action goals and applicable or relevant and appropriate requirements (ARARs). Section 4 describes four alternatives, Section 5 analyzes the alternatives in detail, and Section 6 compares the alternatives. Section 6 also includes a summary and a recommended corrective action.« less

78 FR 37221 - Information Collection Request Submitted to OMB for Review and Approval; Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... chemistry and toxicology data. In addition, EPA must ensure that adequate enforcement of the tolerance can... (pesticide and other agricultural chemical manufacturing) and 541600 (management, scientific, and technical...

40 CFR 176.1 - Scope and applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... or crisis exemptions under FIFRA section 18. This part applies only to tolerances issued on the initiative of EPA as the result of the issuance of an emergency exemption or the declaration of a crisis...

Final work plan : phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Montgomery City, Missouri.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Environmental Science Division

From September 1949 until September 1966, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) leased property at the southeastern end of Montgomery City, Missouri, for the operation of a grain storage facility. During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities. In January 2000, carbon tetrachloride was detected in a soil sample (220 {micro}g/kg) and two soil gas samples (58 {micro}g/m{sup 3} and 550 {micro}g/m{sup 3}) collected at the former CCC/USDA facility, as a result of a pre-CERCLIS sitemore » screening investigation (SSI) performed by TN & Associates, Inc., on behalf of the U.S. Environmental Protection Agency (EPA), Region VII (MoDNR 2001). In June 2001, the Missouri Department of Natural Resources (MoDNR) conducted further sampling of the soils and groundwater at the former CCC/USDA facility as part of a preliminary assessment/site inspection (PA/SI). The MoDNR confirmed the presence of carbon tetrachloride (at a maximum identified concentration of 2,810 {micro}g/kg) and chloroform (maximum 82 {micro}g/kg) in the soils and also detected carbon tetrachloride and chloroform (42.2 {micro}g/L and 58.4 {micro}g/L, respectively) in a groundwater sample collected at the former facility (MoDNR 2001). The carbon tetrachloride levels identified in the soils and groundwater are above the default target level (DTL) values established by the MoDNR for this contaminant in soils of all types (79.6 {micro}g/kg) and in groundwater (5.0 {micro}g/L), as outlined in Missouri Risk-Based Corrective Action (MRBCA): Departmental Technical Guidance (MoDNR 2006a). The corresponding MRBCA DTL values for chloroform are 76.6 {micro}g/kg in soils of all types and 80 {micro}g/L in groundwater. Because the observed contamination at Montgomery City might be linked to the past use of carbon tetrachloride-based fumigants at its former grain storage facility, the CCC/USDA will conduct investigations to (1) characterize the source(s), extent, and factors controlling the possible subsurface distribution and movement of carbon tetrachloride at the Montgomery City site and (2) evaluate the health and environmental threats potentially represented by the contamination. This work will be performed in accord with the Intergovernmental Agreement established between the Farm Service Agency of the USDA and the MoDNR, to address carbon tetrachloride contamination potentially associated with a number of former CCC/USDA grain storage facilities in Missouri. The investigations at Montgomery City will be conducted on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by UChicago Argonne, LLC, for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an agreement with DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. The site characterization at Montgomery City will take place in phases. This approach is recommended by the CCC/USDA and Argonne, so that information obtained and interpretations developed during each incremental stage of the investigation can be used most effectively to guide subsequent phases of the program. This site-specific Work Plan outlines the specific technical objectives and scope of work proposed for Phase I of the Montgomery City investigation. This Work Plan also includes the community relations plan to be followed throughout the CCC/USDA program at the Montgomery City site. Argonne is developing a Master Work Plan specific to operations in the state of Missouri. In the meantime, Argonne has issued a Provisional Master Work Plan (PMWP; Argonne 2007) that has been reviewed and approved by the MoDNR for current use. The PMWP (Argonne 2007) provides detailed information and guidance on the investigative technologies, analytical methodologies, quality assurance-quality control measures, and general health and safety policies to be employed by Argonne for all investigations at former CCC/USDA grain storage facilities in Missouri. Both the PMWP and this site-specific Work Plan must therefore be consulted for a complete description of the planned Phase I work at the former CCC/USDA facility at Montgomery City.« less

Food irradiation in the United States: irradiation as a phytosanitary treatment for fresh fruits and vegetables and for the control of microorganisms in meat and poultry

NASA Astrophysics Data System (ADS)

Ross, Ralph T.; Engeljohn, Dan

2000-03-01

Recently there has been a renewed focus on food irradiation in the United States (US) for the disinfestation of fresh fruits and vegetables to eliminate pests from imported agricultural commodities that could threaten the economic viability of American agriculture and for the control of bacterium E. coli 0157:H7 in beef, a pathogen that threatens the safety of the US domestic food supply. In January 1999 USDA/APHIS published in the Federal Register a rule which authorized irradiation as a guarantee treatment for papayas for movement from Hawaii to the US mainland. This treatment was never used for a number of reasons. However, in December, 1993, the US Environmental Protection Agency (EPA) published its final rule to terminate production and consumption of methyl bromide, the only remaining broad spectrum fumigant for disinfesting agricultural commodities for pests of quarantine significance on imported and exported commodities. With increased global trade pressures and the possible loss of methyl bromide as a fumigant for regulatory pests treatment made it imperative that practical treatment options be explored including irradiation. In May 1996, USDA/APHIS published a Notice of Policy which sets forth a policy statement that share positions and policies of USDA concerning the use of irradiation as a phytosanitary treatment. Subsequently in July, 1997, USDA/APHIS amended its Hawaiian regulation by increasing the dose required for papayas intended for interstate movement and by allowing carambolas and litchis also to move interstate as well. Fruits from Hawaii to the US mainland are currently being irradiated and distributed in commerce throughout the US Irradiation treatments now afford movement of many exotic fruits to the US mainland that could not be done earlier due to the lack of available treatment methods. To help combat this potential public health problem, the US Food and Drug Administration (FDA) approved treating red meat products. This process has been favorably received by the US food industries and health organizations because it can control E. coli 0157:H7 and several other disease-causing microorganisms. However, irradiation will not be authorized until the USDA Food Safety and Inspection Service (FSIS), the US federal agency that regulates meat and poultry products, finalizes it regulations.

78 FR 46265 - Complex Polymeric Polyhydroxy Acids; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

... number of analyses to determine the risks from aggregate exposure to pesticide residues. First, EPA... agricultural soils. Its major components are humic acid, fulvic acid, and tannins, and their relative...

EnviroAtlas - New York, NY - One Meter Resolution Urban Land Cover Data (2008) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas ). The New York, NY EnviroAtlas Meter-scale Urban Land Cover (MULC) Data were generated by the University of Vermont Spatial Analysis Laboratory (SAL) under the direction of Jarlath O'Neil-Dunne as part of the United States Forest Service Urban Tree Canopy (UTC) assessment program. Seven classes were mapped using LiDAR and high resolution orthophotography: Tree Canopy, Grass/Shrub, Bare Soil, Water, Buildings, Roads/Railroads, and Other Paved Surfaces. These data were subsequently merged to fit with the EPA classification. The SAL project covered the five boroughs within the NYC city limits. However the EPA study area encompassed that area plus a 1 kilometer buffer. Additional land cover for the buffer area was generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution from July, 2011 and LiDAR from 2010. Six land cover classes were mapped: water, impervious surfaces, soil and barren land, trees, grass-herbaceous non-woody vegetation, and agriculture. An accuracy assessment of 600 completely random and 55 stratified random photo interpreted reference points yielded an overall User's fuzzy accuracy of 87 percent. The area mapped is the US Census Bureau's 2010 Urban Statistical Area for New Yor

Reassessment of the effects of construction dewatering on ground-water levels in the Cowles Unit, Indiana Dunes National Lakeshore, Indiana : Supplement to Geological Survey Water Resources Investigations 78-138

USGS Publications Warehouse

Gillies, Daniel C.; Lapham, Wayne W.

1980-01-01

A revised dewatering plan for the construction of a nuclear power plant at the Northern Indiana Public Service Company 's (NIPSCO) Bailly Generating Station and evidence that suggests that a change in the characteristics of the confining unit 2 in and near Cowles Bog National Landmark may exist have resulted in a reassessment of the effects of construction dewatering on ground-water levels in the Indiana Dunes National Lakeshore. Model results indicate that the revision in the dewatering plan produces water-level declines that do not differ significantly from those described previously. However, when the change in the confining unit beneath Cowles Bog is considered, simulations of the simultaneous decline of a seepage mound after sealing of the fly-ash-ponds and the second phase of construction dewatering indicate that the simulated water-level declines in the aquifer unit 1 at Cowles Bog may be below the water levels tolerated by the National Park Service after 18 months. The water levels may even decline below the tolerable levels in spite of NIPSCO 's proposed plan of artificially recharging the aquifer unit 1 near the excavation site at 400 gal/min. The magnitude of the simulated water-level declines in unit 1 within the Lakeshore, caused by pumping from the excavation, depends on the relation in time between the second phase of dewatering and the decline of the seepage mound after sealing of the fly-ash-ponds, but not on the duration of dewatering beyond 18 months. (USGS)

75 FR 28488 - Silver Nitrate; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... water and surface water are derived mainly from mineralization of soil organic matter as well as from application of mineral fertilizers. The EPA IRIS lists an oral RfD for chronic noncarcinogenic health effects...

78 FR 36093 - Fenpyroximate; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

... pesticide manufacturer. The following list of North American Industrial Classification System (NAICS) codes... there is reliable information.'' This includes exposure through drinking water and in residential... the available scientific data and other relevant information in support of this action. EPA has...

78 FR 33744 - Sedaxane; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

.... The following list of North American Industrial Classification System (NAICS) codes is not intended to... the data supporting the petition, EPA has corrected commodity definitions and recommended additional... exposure through drinking water and in residential settings, but does not include occupational exposure...

77 FR 66715 - Fluridone; Pesticide Tolerances for Emergency Exemptions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

..., or pesticide manufacturer. The following list of North American Industrial Classification System... for which there is reliable information.'' This includes exposure through drinking water and in... emergency conditions, EPA has not made any decisions about whether fluridone meets FIFRA's registration...

78 FR 53039 - Pyraclostrobin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

... behavior changes were not observed. In the rat developmental toxicity study, developmental toxicity... requires EPA to give special consideration to exposure of infants and children to the pesticide chemical... result to infants and children from aggregate exposure to the pesticide chemical residue...

EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet.

PubMed

Pinel, Alexandre; Pitois, Elodie; Rigaudiere, Jean-Paul; Jouve, Chrystele; De Saint-Vincent, Sarah; Laillet, Brigitte; Montaurier, Christophe; Huertas, Alain; Morio, Beatrice; Capel, Frederic

2016-08-01

The impact of alpha linolenic acid (ALA), EPA, and DHA on obesity and metabolic complications was studied in mice fed a high-fat, high-sucrose (HF) diet. HF diets were supplemented with ALA, EPA, or DHA (1% w/w) and given to C57BL/6J mice for 16 weeks and to Ob/Ob mice for 6 weeks. In C57BL/6J mice, EPA reduced plasma cholesterol (-20%), limited fat mass accumulation (-23%) and adipose cell hypertrophy (-50%), and reduced plasma leptin concentration (-60%) compared with HF-fed mice. Furthermore, mice supplemented with EPA exhibited a higher insulin sensitivity (+24%) and glucose tolerance (+20%) compared with HF-fed mice. Similar effects were observed in EPA-supplemented Ob/Ob mice, although fat mass accumulation was not prevented. By contrast, in comparison with HF-fed mice, DHA did not prevent fat mass accumulation, increased plasma leptin concentration (+128%) in C57BL/6J mice, and did not improve glucose homeostasis in C57BL/6J and Ob/Ob mice. In 3T3-L1 adipocytes, DHA stimulated leptin expression whereas EPA induced adiponectin expression, suggesting that improved leptin/adiponectin balance may contribute to the protective effect of EPA. In conclusion, supplementation with EPA, but not ALA and DHA, could preserve glucose homeostasis in an obesogenic environment and limit fat mass accumulation in the early stage of weight gain. Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc.

Meter-scale Urban Land Cover Mapping for EPA EnviroAtlas Using Machine Learning and OBIA Remote Sensing Techniques

NASA Astrophysics Data System (ADS)

Pilant, A. N.; Baynes, J.; Dannenberg, M.; Riegel, J.; Rudder, C.; Endres, K.

2013-12-01

US EPA EnviroAtlas is an online collection of tools and resources that provides geospatial data, maps, research, and analysis on the relationships between nature, people, health, and the economy (http://www.epa.gov/research/enviroatlas/index.htm). Using EnviroAtlas, you can see and explore information related to the benefits (e.g., ecosystem services) that humans receive from nature, including clean air, clean and plentiful water, natural hazard mitigation, biodiversity conservation, food, fuel, and materials, recreational opportunities, and cultural and aesthetic value. EPA developed several urban land cover maps at very high spatial resolution (one-meter pixel size) for a portion of EnviroAtlas devoted to urban studies. This urban mapping effort supported analysis of relations among land cover, human health and demographics at the US Census Block Group level. Supervised classification of 2010 USDA NAIP (National Agricultural Imagery Program) digital aerial photos produced eight-class land cover maps for several cities, including Durham, NC, Portland, ME, Tampa, FL, New Bedford, MA, Pittsburgh, PA, Portland, OR, and Milwaukee, WI. Semi-automated feature extraction methods were used to classify the NAIP imagery: genetic algorithms/machine learning, random forest, and object-based image analysis (OBIA). In this presentation we describe the image processing and fuzzy accuracy assessment methods used, and report on some sustainability and ecosystem service metrics computed using this land cover as input (e.g., carbon sequestration from USFS iTREE model; health and demographics in relation to road buffer forest width). We also discuss the land cover classification schema (a modified Anderson Level 1 after the National Land Cover Data (NLCD)), and offer some observations on lessons learned. Meter-scale urban land cover in Portland, OR overlaid on NAIP aerial photo. Streets, buildings and individual trees are identifiable.

76 FR 77703 - Hexythiazox; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... the relationship of the results of the studies to human risk. EPA has also considered available... effects including potential carcinogenicity of hexythiazox. Specific information on the studies received...-level (NOAEL) and the lowest-observed-adverse-effect- level (LOAEL) from the toxicity studies can be...

76 FR 55799 - Mandipropamid; Pesticide Tolerances for Emergency Exemptions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-09

... affected. The North American Industrial Classification System (NAICS) codes have been provided to assist....'' This includes exposure through drinking water and in residential settings, but does not include... are being approved under emergency conditions, EPA has not made any decisions about whether...

78 FR 13252 - Pyroxasulfone; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... one of the following methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the... relationship of the results of the studies to human risk. EPA has also considered available information... adverse effects in several target organs. Effects seen in animal studies included cardiac toxicity...

75 FR 22256 - Difenoconazole Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... http://www.gpoaccess.gov/ecfr . To access the OPPTS Harmonized Test Guidelines referenced in this document electronically, please go to http://www.epa.gov/oppts and select ``Test Methods & Guidelines'' on... food as follows: i. Acute exposure. Quantitative acute dietary exposure and risk assessments are...

78 FR 8407 - Endosulfan; Pesticide Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

..., food manufacturers, or pesticide manufacturers. The following list of North American Industrial... (NAICS code 111). Animal Production (NAICS code 112). Food Manufacturing (NAICS code 311). Pesticide... statutory standards of the Federal Food, Drug and Cosmetic Act (FFDCA) section 408. EPA may in the future...

Role of adenosine receptors in caffeine tolerance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holtzman, S.G.; Mante, S.; Minneman, K.P.

1991-01-01

Caffeine is a competitive antagonist at adenosine receptors. Receptor up-regulation during chronic drug treatment has been proposed to be the mechanism of tolerance to the behavioral stimulant effects of caffeine. This study reassessed the role of adenosine receptors in caffeine tolerance. Separate groups of rats were given scheduled access to drinking bottles containing plain tap water or a 0.1% solution of caffeine. Daily drug intake averaged 60-75 mg/kg and resulted in complete tolerance to caffeine-induced stimulation of locomotor activity, which could not be surmounted by increasing the dose of caffeine. 5'-N-ethylcarboxamidoadenosine (0.001-1.0 mg/kg) dose dependently decreased the locomotor activity ofmore » caffeine-tolerant rats and their water-treated controls but was 8-fold more potent in the latter group. Caffeine (1.0-10 mg/kg) injected concurrently with 5-N-ethylcarboxamidoadenosine antagonized the decreases in locomotor activity comparably in both groups. Apparent pA2 values for tolerant and control rats also were comparable: 5.05 and 5.11. Thus, the adenosine-antagonist activity of caffeine was undiminished in tolerant rats. The effects of chronic caffeine administration on parameters of adenosine receptor binding and function were measured in cerebral cortex. There were no differences between brain tissue from control and caffeine-treated rats in number and affinity of adenosine binding sites or in receptor-mediated increases (A2 adenosine receptor) and decreases (A1 adenosine receptor) in cAMP accumulation. These results are consistent with theoretical arguments that changes in receptor density should not affect the potency of a competitive antagonist. Experimental evidence and theoretical considerations indicate that up-regulation of adenosine receptors is not the mechanism of tolerance to caffeine-induced stimulation of locomotor activity.« less

EnviroAtlas -- Green Bay, Wisconsin -- One Meter Resolution Urban Land Cover Data (2010)

EPA Pesticide Factsheets

The Green Bay, WI one meter-scale urban land cover (LC) dataset comprises 936 km2 around the city of Green Bay, surrounding towns, tribal lands and rural areas in Brown and Outagamie Counties. These leaf-on LC data and maps were derived from 1-m pixel, four-band (red, green, blue, and near-infrared) aerial photography acquired from the United States Department of Agriculture (USDA) National Agriculture Imagery Program (NAIP) on three dates in 2010: July 3, July 25, and August 5. LiDAR data collected on November 18, 2010 was integrated for the Brown County portion. Eight land cover classes were mapped: water, impervious surfaces, soil and barren land, trees and forest, grass and herbaceous non-woody vegetation, agriculture, and wetlands (woody and emergent). Wetlands were copied from the best available existing wetlands data. Analysis of a random sampling of 566 photo-interpreted land cover reference points yielded an overall accuracy of 91.3%. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can b

EnviroAtlas -- Fresno, California -- One Meter Resolution Urban Land Cover Data (2010) Web Service

EPA Pesticide Factsheets

This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The Fresno, CA EnviroAtlas One-Meter-scale Urban Land Cover Data were generated via supervised classification of combined aerial photography and LiDAR data. The air photos were United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1-m spatial resolution. Aerial photography ('imagery') was collected on multiple dates in summer 2010. Seven land cover classes were mapped: Water, impervious surfaces (Impervious), soil and barren (Soil), trees and forest (Tree), and grass and herbaceous non-woody vegetation (Grass), agriculture (Ag), and Orchards. An accuracy assessment of 500 completely random and 103 stratified random points yielded an overall User's fuzzy accuracy of 81.1 percent (see below). The area mapped is defined by the US Census Bureau's 2010 Urban Statistical Area for Fresno, CA plus a 1-km buffer. Where imagery was available, additional areas outside the 1-km boundary were also mapped but not included in the accuracy assessment. We expect the accuracy of the areas outside of the 1-km boundary to be consistent with those within. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with

EnviroAtlas - New York, NY - One Meter Resolution Urban Land Cover Data (2008)

EPA Pesticide Factsheets

The New York, NY EnviroAtlas Meter-scale Urban Land Cover (MULC) Data were generated by the University of Vermont Spatial Analysis Laboratory (SAL) under the direction of Jarlath O'Neil-Dunne as part of the United States Forest Service Urban Tree Canopy (UTC) assessment program. Seven classes were mapped using LiDAR and high resolution orthophotography: Tree Canopy, Grass/Shrub, Bare Soil, Water, Buildings, Roads/Railroads, and Other Paved Surfaces. These data were subsequently merged to fit with the EPA classification. The SAL project covered the five boroughs within the NYC city limits. However the EPA study area encompassed that area plus a 1 kilometer buffer. Additional land cover for the buffer area was generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP) four band (red, green, blue, and near infrared) aerial photography at 1 m spatial resolution from July, 2011 and LiDAR from 2010. Six land cover classes were mapped: water, impervious surfaces, soil and barren land, trees, grass-herbaceous non-woody vegetation, and agriculture. An accuracy assessment of 600 completely random and 55 stratified random photo interpreted reference points yielded an overall User's fuzzy accuracy of 87 percent. The area mapped is the US Census Bureau's 2010 Urban Statistical Area for New York City plus a 1 km buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAt

EnviroAtlas - Minneapolis/St. Paul, MN - One Meter Resolution Urban Area Land Cover Map (MULC) (2010)

EPA Pesticide Factsheets

The Minneapolis-St. Paul, MN EnviroAtlas Meter-scale Urban Land Cover (MULC) data were generated from four-band (red, green, blue, and near infrared) aerial photography provided by the United States Department of Agriculture (USDA) National Agricultural Imagery Program (NAIP). The NAIP imagery for the state of Minnesota was collected during the summer and fall of 2010. Lidar data and relevant ancillary datasets contributed to the classification. Eight land cover types were classified: water, impervious surface, soil and barren land, trees and forest, grass and herbaceous, agriculture, woody wetland, and emergent wetland. An accuracy assessment of 644 completely random and 62 stratified random photointerpreted reference points yielded an overall User's Accuracy of 83 percent. The boundary of this data layer is delineated by the US Census Bureau's 2010 Urban Statistical Area for Minneapolis-St. Paul, MN plus a 1-km buffer. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associat

East Fork Watershed Cooperative: Toward better system-scale ...

EPA Pesticide Factsheets

The East Fork Watershed Cooperative is a group intent on understanding how to best manage water quality in a large mixed-use Midwestern watershed system. The system contains a reservoir that serves as a source of drinking water and is popular for water recreation. The reservoir is experience harmful algal blooms. The system including the reservoir has become a significant case study for EPA ORD research and development. The Cooperative includes affiliates from the USACE, the OHIO EPA, the USGS, the USDA, and local Soil and Water Conservation districts as well as utility operators and water quality protection offices. The presentation includes a description of the water quality monitoring and modeling program in the watershed, followed by the results of using the watershed model to estimate the costs associated with nutrient reduction to Harsha Lake, and then ends with an explanation of temporal changes observed for important factors controlling harmful algae in Harsha Lake and how this lake relates to other reservoirs in the Ohio River Basin. This presentation is an invited contribution to the Ohio River Basin Water Quality Workshop sponsored by the US ACE and the US EPA. The presentation describes the activities of the East Fork Watershed Cooperative and the knowledge it has gained to help better manage a case study watershed system over the last few years. The East Fork of the Little Miami River is the focal watershed. It is a significant tributary to the Lit

78 FR 20461 - Flumioxazin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

..., or pesticide manufacturer. The following list of North American Industrial Classification System... response to the notice of filing. Based upon review of the data supporting the petition, EPA has modified... drinking water and in residential settings, but does not include occupational exposure. Section 408(b)(2)(C...

77 FR 26467 - Fluoxastrobin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-04

... could also be affected. The North American Industrial Classification System (NAICS) codes have been... to the notice of filing. Based upon review of the data supporting the petition, EPA has corrected the....'' This includes exposure through drinking water and in residential settings, but does not include...

78 FR 71523 - Quinclorac; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-29

... pesticide manufacturer. The following list of North American Industrial Classification System (NAICS) codes....'' This includes exposure through drinking water and in residential settings, but does not include... information in support of this action. EPA has sufficient data to assess the hazards of and to make a...

75 FR 14086 - Clopyralid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... listed in this unit could also be affected. The North American Industrial Classification System (NAICS... notice of filing. Based upon review of the data supporting the petition, EPA has revised the proposed... for which there is reliable information.'' This includes exposure through drinking water and in...

75 FR 17566 - Flutolanil; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... affected. The North American Industrial Classification System (NAICS) codes have been provided to assist...) benzamide and calculated as flutolanil.'' Based on review of the data supporting the petition, EPA has also... exposures for which there is reliable information.'' This includes exposure through drinking water and in...

Setting Tolerances for Pesticide Residues in Foods

EPA Pesticide Factsheets

Pesticides are widely used in producing food and may remain in small amounts in or on fruits, vegetables, grains, and other foods. EPA ensures the safety of the food supply regulating the amount of pesticide that may remain on food. Learn how we do this.

78 FR 23497 - Propiconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-19

...). Animal production (NAICS code 112). Food manufacturing (NAICS code 311). Pesticide manufacturing (NAICS.... Aggregate Risk Assessment and Determination of Safety Section 408(b)(2)(A)(i) of FFDCA allows EPA to... dose at which adverse effects of concern are identified (the LOAEL). Uncertainty/safety factors are...

75 FR 29908 - Prothioconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

....gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go http://www.epa.gov/ocspp and select ``Test Methods and Guidelines.'' C. Can I File an Objection... dietary exposures and all other exposures for which there is reliable information.'' This includes...

77 FR 12207 - Pyroxasulfone; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... and post- natal toxicity database for pyroxasulfone includes developmental toxicity studies in rats... study and developmental toxicity study in rabbits following in utero or post-natal exposure to... reliability as well as the relationship of the results of the studies to human risk. EPA has also considered...

76 FR 18906 - Mancozeb; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... from mancozeb and ETU in food as follows: i. Acute exposure. Quantitative acute dietary exposure and.... Cancer. EPA determines whether quantitative cancer exposure and risk assessments are appropriate for a... quantitative cancer risk assessment is appropriate, cancer risk may be quantified using a linear or nonlinear...

Gastrointestinal tolerance and plasma status of carotenoids, EPA and DHA with a fiber-enriched tube feed in hospitalized patients initiated on tube nutrition: Randomized controlled trial.

PubMed

Jakobsen, L H; Wirth, R; Smoliner, C; Klebach, M; Hofman, Z; Kondrup, J

2017-04-01

During the first days of tube feeding (TF) gastrointestinal (GI) complications are common and administration of sufficient nutrition is a challenge. Not all standard nutritionally complete formulas contain dietary fiber, fish oil or carotenoids, key dietary nutrients for health and wellbeing. The aim of this study was to investigate the effects of a fiber, fish oil and carotenoid enriched TF formula on diarrhea, constipation and nutrient bioavailability. A multi-center randomized, double-blind, controlled, parallel trial compared the effects of a dietary fiber, fish oil and carotenoid-enriched TF formula (test) with an isocaloric non-enriched formula (control) in 51 patients requiring initiation of TF. Incidence of diarrhea and constipation (based on stool frequency and consistency) was recorded daily. Plasma status of EPA, DHA and carotenoids was measured after 7 days. The incidence of diarrhea was lower in patients receiving the test formula compared with the control group (19% vs. 48%, p = 0.034). EPA and DHA status (% of total plasma phospholipids) was higher after 7 days in test compared with control group (EPA: p = 0.002, DHA: p = 0.082). Plasma carotenoid levels were higher after 7 days in the test group compared with control group (lutein: p = 0.024, α-carotene: p = 0.005, lycopene: p = 0.020, β-carotene: p = 0.054). This study suggests that the nutrient-enriched TF formula tested might have a positive effect on GI tolerance with less diarrhea incidence and significantly improved EPA, DHA and carotenoid plasma levels during the initiation of TF in hospitalized patients who are at risk of diarrhea and low nutrient status. This trial was registered at trialregister.nl; registration number 2924. Copyright © 2016. Published by Elsevier Ltd.

77 FR 66723 - Fluazinam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-07

... pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. Submit the non-CBI copy of...-(trifluoromethyl)phenyl]-5- (trifluoromethyl)-2-pyridinamine), in or on fruiting vegetables group, pepper/eggplant...,000 ppm were slightly outside their respective ranges for the historical controls. However, this...

75 FR 69005 - Flumioxazin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

... reproduction studies indicated an effect on the nervous systems. Based on the lack of evidence of... flumioxazin does not directly impact the nervous system or directly target the immune system. The Agency does... to indicate that flumioxazin targets the nervous system or the immune system. Further, EPA has...

76 FR 18899 - Indaziflam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... Model/Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI... Classification System (NAICS) codes have been provided to assist you and others in determining whether this... response to the notice of filing. Based upon review of the data supporting the petitions, EPA has modified...

77 FR 70902 - Fenpropathrin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-28

... manufacturer. The following list of North American Industrial Classification System (NAICS) codes is not... response to the notice of filing. Based upon review of the data supporting the petition, EPA has revised... drinking water and in residential settings, but does not include occupational exposure. Section 408(b)(2)(C...

77 FR 40806 - Methoxyfenozide; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-11

.../Exposure Analysis Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI- GROW... System (NAICS) codes have been provided to assist you and others in determining whether this action might... response to the notice of filing. Based upon review of the data supporting the petitions, EPA has modified...

76 FR 27261 - Propiconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... identified and discussed later in this document. Interregional Research Project 4 (IR-4) requested these... e-CFR site at http://www.gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and...

78 FR 13295 - Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

...: [email protected] . 5. PP 2F8130. (EPA-HQ-OPP-2012-0576). Arysta LifeScience North America, LLC...-2012-0576). Arysta LifeScience North America, LLC, requests to revise the tolerances in 40 CFR 180.609...

75 FR 54033 - Thiabendazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... residential exposures: paint and sponges. These residential uses have been assessed and aggregated with the food and water exposures. EPA assumed that 5% of the thiabendazole on sponges is transferred to the... females and small children exposed to surfaces cleaned with treated sponges. No risks of concern were seen...

Solvents, Ethanol, Car Crashes and Tolerance: How Risky is Inhalation of Organic Solvents?

EPA Science Inventory

A research program in the National Health and Environmental Effects Research Laboratory of the U.S. EPA has led to some surprising considerations regarding the potential hazard of exposure to low concentrations of solvent vapors. This program involved conducting experiments to ch...

77 FR 38204 - Cyflufenamid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... minimal frequency and duration of contact; Children young enough to exhibit hand-to-mouth behavior would...) of FFDCA requires EPA to give special consideration to exposure of infants and children to the... that no harm will result to infants and children from aggregate exposure to the pesticide chemical...

Contact USDA-ARS | USDA Plant Hardiness Zone Map

Science.gov Websites

USDA Logo Agricultural Research Service United States Department of Agriculture Mapping by PRISM / Help / Contact USDA-ARS Topics How to Use This Website Contact USDA-ARS Contact USDA Agricultural Mapping, please contact the USDA Agricultural Research Service by sending an e-mail to phzm@ars.usda.gov

77 FR 36919 - Sedaxane; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... no comments received in response to the notice of filing. Based upon review of the data supporting... scientific data and other relevant information in support of this action. EPA has sufficient data to assess.... Human Health Risk Assessment to Support New Seed Treatment Uses on Canola, Cereal Grains (Barley, Oat...

77 FR 72975 - Zeta Cypermethrin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

... confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. Submit the non... physiological differences between abraded and non-abraded animals, further undermining the relevance of these... classified as a Group C ``Possible human carcinogen,'' based on an increased incidence of lung adenomas and...

78 FR 75262 - Flonicamid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

... publicly by EPA without prior notice. Submit the non-CBI copy of your objection or hearing request...- trifluoromethylnicotinamide), and TFNG (N-(4- trifluoromethylnicotinoyl)glycine), calculated as the stoichiometric equivalent..., tops at 7.0 ppm; spearmint, tops at 7.0 ppm; vegetable, fruiting, group 8-10 at 0.40 ppm; vegetable...

76 FR 34877 - Difenoconazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... non-occupational, non-dietary exposure (e.g., for lawn and garden pest control, indoor pest control...; chickpea; fruits, stone, group 12; soybean, hulls; soybean, seed; strawberry; and turnip greens. Syngenta... pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. Submit a copy of your non...

77 FR 45495 - 2-Methyl-1,3-propanediol; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... component of food contact sanitizing solutions applied to all food contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. Lyondell Chemical Company submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment...

78 FR 33731 - Propamocarb; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... Modeling System (PRZM/EXAMS) and Screening Concentration in Ground Water (SCI- GROW) models, the estimated... Classification System (NAICS) codes is not intended to be exhaustive, but rather provides a guide to help readers... to the notice of filing. Based upon review of the data supporting the petition, EPA has revised the...

78 FR 24094 - Azoxystrobin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... Classification System (NAICS) codes is not intended to be exhaustive, but rather provides a guide to help readers... response to the notice of filing. Based upon review of the data supporting the petition, EPA is... exposures for which there is reliable information.'' This includes exposure through drinking water and in...

75 FR 40741 - Hexythiazox; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

.../oppefed1/models/water/index.htm . Based on the Pesticide Root Zone Model /Exposure Analysis Modeling System... affected. The North American Industrial Classification System (NAICS) codes have been provided to assist... review of the data supporting the petition, EPA issued a notice in the Federal Register of March 17, 2010...

77 FR 68686 - Xylenesulfonic Acid, Sodium Salt; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... this methodology is compounded by EPA's decision to assume that, for each commodity, the active... be affected. The North American Industrial Classification System (NAICS) codes have been provided to....'' This includes exposure through drinking water and in residential settings, but does not include...

PLATYAMOEBA PSEUDOVANNELLIDA N. SP., A NAKED AMOEBA WITH WIDE SALT TOLERANCE ISOLATED FROM THE SALTON SEA, CALIFORNIA. (R826552)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

76 FR 69653 - Abamectin (avermectin); Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... are available in Pesticide Analytical Manual II (PAM II) for citrus and processed fractions (Method I... (ID) number EPA-HQ-OPP-2010-0619. All documents in the docket are listed in the docket index available... available, e.g., Confidential Business Information (CBI) or other information whose disclosure is restricted...

40 CFR 176.7 - Information needed to establish a tolerance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... to the pesticide chemical residue. EPA will base its determination upon data submitted by the applicant and other readily available data. If, taking into account the limited duration and emergency nature of a section 18 application, and based on the available data the Agency cannot conclude that there...

75 FR 4284 - Triticonazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... harmonized test guidelines referenced in this document electronically, please go to http://www.epa.gov/oppts and select ``Test Methods & Guidelines'' on the left-side navigation menu. C. Can I File an Objection..., P.O. Box 13528, Research Triangle Park, NC 27709-3528. The petition requested that 40 CFR 180.583 be...

77 FR 23135 - 2,4-D; Order Denying NRDC's Petition To Revoke Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... cannot be determined (``non-threshold effects''). Because EPA identified only threshold effect risks for... uncertainty or safety factors \\1\\ in conjunction with experimental toxicity data in assessing risk to humans... difference in sensitivity between humans and experimental animals (i.e., inter-species sensitivity) and...

75 FR 8500 - 1,2,3-Propanetriol, Homopolymer Diisooctadecanoate; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

....'' This includes exposure through drinking water and in residential settings, but does not include..., EPA examines exposure to the pesticide through food, drinking water, and through other exposures that... other non-occupational exposures, including drinking water from ground water or surface water and...

75 FR 74628 - Tristyrylphenol Ethoxylates; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting the establishment of an... be potentially affected by this action if you are an agricultural producer, food manufacturer, or... (NAICS code 111). Animal production (NAICS code 112). Food manufacturing (NAICS code 311). Pesticide...

78 FR 78740 - Isopyrazam; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... access the OCSPP test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select ``Test Methods and Guidelines.'' C. How can I file an objection or hearing... validity, completeness, and reliability as well as the relationship of the results of the studies to human...

75 FR 55991 - Ammonium Formate; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

... lifelong study in rats via drinking water did not produce any systemic toxicity. Therefore, a conservative... for ammonium formate. In the absence of specific residue data, EPA has developed an approach which... high-use insecticides, herbicides, and fungicides. A complete description of the general approach taken...

77 FR 10968 - Fluopyram; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... 16 ppm; vegetable, fruiting, except non-bell pepper, group 8 at 1.0 ppm; vegetable, leafy, except... sufficient information on the carcinogenic mode of action is available, a threshold or non-linear approach is... notice. Submit a copy of your non-CBI objection or hearing request, identified by docket ID number EPA-HQ...

76 FR 31471 - Ethylene Glycol; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... production (NAICS code 112). Food manufacturing (NAICS code 311). Pesticide manufacturing (NAICS code 32532..., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an... residual, and crack and crevice sprays in and around food and nonfood areas of residential and...

THE US EPA'S DERMAL EXPOSURE RESEARCH PROGRAM IN SUPPORT OF THE FOOD QUALITY PROTECTION ACT

EPA Science Inventory

The Food Quality Protection Act of 1996 (FQPA) requires that children's risks to pesticide exposures be considered during the tolerance-setting process. FQPA requires exposure assessments to be conducted for all pesticides sources, not just food sources. It also requires tha...

78 FR 67042 - Boscalid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

..., group 11 at 3.0 ppm; grape at 3.5 ppm; strawberry at 4.5 ppm; sunflower, seed at 0.6 ppm; vegetable...%; squash 5%; strawberries 55%; tomatoes 5%; walnuts 1%; and watermelons 25%. In most cases, EPA uses... 10; fruit, pome, group 11; grape; strawberry; sunflower, seed; vegetable, bulb, group 3; and...

ADAPTATION OF CLOSTRIDIUM TYROBUTYRICUM FOR ENHANCED TOLERANCE TO BUTYRIC ACID IN A FIBROUS-BED BIOREACTOR. (R829479C016)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Federal guide for a radiological response: Supporting the Nuclear Regulatory Commission during the initial hours of a serious accident

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hogan, R.T.

1993-11-01

This document is a planning guide for those Federal agencies that work with the Nuclear Regulatory commission (NRC) during the initial hours of response to a serious radiological emergency in which the NRC is the Lead Federal Agency (LFA). These Federal agencies are: DOE, EPA, USDA, HHS, NOAA, and FEMA. This guide is intended to help these agencies prepare for a prompt response. Instructions are provided on receiving the initial notification, the type of person to send to the scene, the facility at which people are needed, how to get them to that facility, and what they should do whenmore » they arrive. Federal agencies not specifically mentioned in this guide may also be asked to support the NRC.« less

EPA-enriched phospholipids ameliorate cancer-associated cachexia mainly via inhibiting lipolysis.

PubMed

Du, Lei; Yang, Yu-Hong; Wang, Yu-Ming; Xue, Chang-Hu; Kurihara, Hideyuki; Takahashi, Koretaro

2015-12-01

Excessive loss of fat mass is considered as a key feature of body weight loss in cancer-associated cachexia (CAC). It affects the efficacy and tolerability of cancer therapy and reduces the quality and length of cancer patients' lives. The aim of the present study was to evaluate the effects of EPA-enriched phospholipids (EPA-PL) derived from starfish Asterias amurensis on cachectic weight loss in mice bearing S180 ascitic tumor, and TNF-α-stimulated lipolysis in 3T3-L1 adipocytes and to elucidate the possible mechanisms involved. Our findings revealed that oral administration of EPA-PL at 100 mg per kg body weight (BW) per day for 14 days prevented body weight loss in CAC mice by preserving the white adipose tissue (WAT) mass. We found that serum levels of nonesterified fatty acid (NEFA) and pro-inflammatory cytokines such as tumor necrosis factor α (TNF-α) and interleukin (IL)-6 increased in CAC mice but decreased significantly after oral treatment of EPA-PL. In addition, EPA-PL treatment also suppressed the overexpression of several key lipolytic factors and raised the mRNA levels of some adipogenic factors in the WAT of CAC mice. Moreover, treatment of EPA-PL (200 and 400 μM) markedly inhibited TNF-α-stimulated lipolysis in adipocytes. Furthermore, the antilipolytic effects of EPA-PL were stimulated by the extracellular signal-regulated kinase 1/2 (ERK 1/2) inhibitor PD 98059 and blocked via the AMP-activated protein kinase (AMPK) inhibitor compound C and the phosphoinositide-3-kinase (PI3K) inhibitor LY 294002. Taken together, these data suggest that the dietary EPA-PL ameliorates CAC mainly via inhibiting lipolysis and at least in part for recovering the function of adipogenesis.

MO-F-CAMPUS-T-03: Data Driven Approaches for Determination of Treatment Table Tolerance Values for Record and Verification Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, N; DiCostanzo, D; Fullenkamp, M

2015-06-15

Purpose: To determine appropriate couch tolerance values for modern radiotherapy linac R&V systems with indexed patient setup. Methods: Treatment table tolerance values have been the most difficult to lower, due to many factors including variations in patient positioning and differences in table tops between machines. We recently installed nine linacs with similar tables and started indexing every patient in our clinic. In this study we queried our R&V database and analyzed the deviation of couch position values from the acquired values at verification simulation for all patients treated with indexed positioning. Mean and standard deviations of daily setup deviations weremore » computed in the longitudinal, lateral and vertical direction for 343 patient plans. The mean, median and standard error of the standard deviations across the whole patient population and for some disease sites were computed to determine tolerance values. Results: The plot of our couch deviation values showed a gaussian distribution, with some small deviations, corresponding to setup uncertainties on non-imaging days, and SRS/SRT/SBRT patients, as well as some large deviations which were spot checked and found to be corresponding to indexing errors that were overriden. Setting our tolerance values based on the median + 1 standard error resulted in tolerance values of 1cm lateral and longitudinal, and 0.5 cm vertical for all non- SRS/SRT/SBRT cases. Re-analizing the data, we found that about 92% of the treated fractions would be within these tolerance values (ignoring the mis-indexed patients). We also analyzed data for disease site based subpopulations and found no difference in the tolerance values that needed to be used. Conclusion: With the use of automation, auto-setup and other workflow efficiency tools being introduced into radiotherapy workflow, it is very essential to set table tolerances that allow safe treatments, but flag setup errors that need to be reassessed before treatments.« less

A Double-Blind Randomized Controlled Trial of Ethyl-Eicosapentaenoate (EPA-E) for Major Depressive Disorder

PubMed Central

Mischoulon, David; Papakostas, George I.; Dording, Christina M.; Farabaugh, Amy H.; Sonawalla, Shamsah B.; Agoston, Monica; Smith, Juliana; Beaumont, Erin; Dahan, Liat; Alpert, Jonathan E.; Nierenberg, Andrew A.; Fava, Maurizio

2010-01-01

Objective We examined the efficacy and tolerability of ethyl-eicosapentaenoate (EPA-E) monotherapy for major depressive disorder (MDD) in a double-blind, randomized controlled pilot study. Methods 57 adults with DSM-IV MDD were randomized from 1/2003-6/2006 to receive 1 gram/day of EPA or placebo (PBO) for 8 weeks. Response criteria were based on the Hamilton-D-17 scale. Subjects' plasma lipid profiles were examined by gas chromatography. Results 35 subjects (63% female; mean age 45+/-13 yrs) were eligible for the intent to treat (ITT) analysis. In the ITT sample, mean HAM-D-17 scores decreased from 21.6+/-2.7 to 13.9+/-8.9 for the EPA group (n=16) and from 20.5+/-3.6 to 17.5+/-7.5 for the PBO group (n=19) (p=0.123); the effect size for EPA was 0.55. ITT response rates were 38% (6/16) for EPA, and 21% (4/19) for PBO (p=0.45). Among the 24 study completers, mean HAM-D-17 scores decreased from 21.3+/-3.0 to 11.1+/-8.1 for the EPA group and from 20.5+/-3.8 to 16.3+/-6.9 for the PBO group (p=0.087); the effect size for EPA was 0.73. Completer response rates were 45% (5/11) for EPA, and 23% (3/13) for PBO (p=0.39). Among EPA subjects, baseline n-6/n-3 ratio was associated with decrease in HAM-D-17 score (r= -0.686, p=0.030) and with treatment response (p=0.032); change in n-6/n-3 ratio was associated with change in HAM-D-17 score (r=0.784, p=0.032). Side effects, reported in 2 EPA subjects and 5 PBO subjects, were exclusively gastrointestinal, mild, and not associated with discontinuation. Conclusions EPA demonstrated an advantage over placebo that did not reach statistical significance, possibly due to the small sample and low completer rates, which were the major study limitations. PMID:19709502

Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise.

PubMed

Walser, Buddy; Stebbins, Charles L

2008-10-01

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects on cardiovascular function. We tested the hypotheses that dietary supplementation with DHA (2 g/day) + EPA (3 g/day) enhances increases in stroke volume (SV) and cardiac output (CO) and decreases in systemic vascular resistance (SVR) during dynamic exercise. Healthy subjects received DHA + EPA (eight men, four women) or safflower oil (six men, three women) for 6 weeks. Both groups performed 20 min of bicycle exercise (10 min each at a low and moderate work intensity) before and after DHA + EPA or safflower oil treatment. Mean arterial pressure (MAP), heart rate (HR), SV, CO, and SVR were assessed before exercise and during both workloads. HR was unaffected by DHA + EPA and MAP was reduced, but only at rest (88 +/- 5 vs. 83 +/- 4 mm Hg). DHA + EPA augmented increases in SV (14.1 +/- 6.3 vs. 32.3 +/- 8.7 ml) and CO (8.5 +/- 1.0 vs. 10.3 +/- 1.2 L/min) and tended to attenuate decreases in SVR (-7.0 +/- 0.6 vs. -10.1 +/- 1.6 mm Hg L(-1) min(-1)) during the moderate workload. Safflower oil treatment had no effects on MAP, HR, SV, CO or SVR at rest or during exercise. DHA + EPA-induced increases in SV and CO imply that dietary supplementation with these fatty acids can increase oxygen delivery during exercise, which may have beneficial clinical implications for individuals with cardiovascular disease and reduced exercise tolerance.

Integrating phytoremediation, wetlands, spray irrigation, and prairie restoration to treat carbon tetrachloride contamination in a rural community.

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, L. M.; Negri, M. C.; Sedivy, R. A.

2006-01-01

In a cooperative conservation effort, the U.S. Department of Agriculture is cleaning up a contaminated aquifer in a rural community and simultaneously improving the community's recreational and educational opportunities. While one component of the cleanup system irrigates school athletic fields that were parched and bare in previous summers, other components have created a nearby public recreational area. The USDA's other partners in this effort are the U.S. Department of Energy's Argonne National Laboratory (ANL) and the U.S. Environmental Protection Agency, Kansas State University, state regulators, local businesses, governmental units, and residents. The groundwater aquifer beneath Murdock, Nebraska, became contaminated withmore » carbon tetrachloride as the result of fumigation of grain stored decades ago in a USDA facility. Contaminant levels in the groundwater (up to 7,800 {micro}g/L at one time) precluded use of the aquifer for drinking water, and discharge of contaminated groundwater to a nearby creek posed health risks. Concentrations of carbon tetrachloride as high as 361 {micro}g/kg in subsurface soil indicated the presence of a soil source. Model simulations of potential leaching indicated that the source would continue to release contaminant for at least 80 years, and migration to the creek would continue after that. The USDA, ANL, and EPA developed an innovative cleanup system that combines multiple technologies. Near the contamination source, pumps extract contaminated groundwater and pass it through a spray irrigation system that dissipates the carbon tetrachloride harmlessly into the air. The treated water irrigates the school's athletic field, nurturing a healthy grassy surface. Supplementing the spray irrigation technology are more than 2,000 trees planted downstream from where the groundwater enters the creek. The trees accomplish phytoremediation by taking up contaminated water and breaking down carbon tetrachloride naturally. Native prairie plants around and between the trees intercept rainwater and force the trees to draw most of their water from the aquifer. The partners are restoring a downstream wetland to intercept lingering traces of carbon tetrachloride and are installing an ADA-accessible, public trail through both the tree plantation and the wetland. Interpretive signs will enhance the visitor's experience and facilitate use of the site as an outdoor 'living' classroom for the local school district. The landowners have welcomed this public outreach aspect of the project. In addition, a visiting scientist program brings technical experts into the school to explain the cleanup effort and answer questions. The EPA has approved a monitoring plan to follow the progress of the cleanup effort and ensure the protection of human health and the environment.« less

Bioavailability of Dietary Omega-3 Fatty Acids Added to a Variety of Sausages in Healthy Individuals

PubMed Central

Köhler, Anton; Heinrich, Johanna; von Schacky, Clemens

2017-01-01

A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to receive a variety of sausages enriched with approximately 250 mg EPA and DHA per 80 g (n = 22) daily for 8 weeks, or matching placebo sausages (n = 22). All sausages contained approximately 250 mg ALA/80 g. In the verum group, the mean Omega-3 Index increased from 4.18 ± 0.54 to 5.72 ± 0.66% (p < 0.001), while it remained unchanged in the placebo group. While ALA levels increased only in the placebo group, DPA levels increased in both groups. Inter-individual variability in the response was large. The mean increase of the Omega-3 Index per intake of EPA and DHA we observed was higher than for other sources previously studied, indicating superior bioavailability. As increasing production of EPA and DHA is difficult, improvements of bioavailability can facilitate reaching the target range for the Omega-3 Index (8–11%). PMID:28629180

Bioavailability of Dietary Omega-3 Fatty Acids Added to a Variety of Sausages in Healthy Individuals.

PubMed

Köhler, Anton; Heinrich, Johanna; von Schacky, Clemens

2017-06-19

A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerability of EPA and DHA in a novel source: a variety of sausages. We screened 96 healthy volunteers, and recruited 44 with an Omega-3 Index <5%. Participants were randomly assigned to receive a variety of sausages enriched with approximately 250 mg EPA and DHA per 80 g ( n = 22) daily for 8 weeks, or matching placebo sausages ( n = 22). All sausages contained approximately 250 mg ALA/80 g. In the verum group, the mean Omega-3 Index increased from 4.18 ± 0.54 to 5.72 ± 0.66% ( p < 0.001), while it remained unchanged in the placebo group. While ALA levels increased only in the placebo group, DPA levels increased in both groups. Inter-individual variability in the response was large. The mean increase of the Omega-3 Index per intake of EPA and DHA we observed was higher than for other sources previously studied, indicating superior bioavailability. As increasing production of EPA and DHA is difficult, improvements of bioavailability can facilitate reaching the target range for the Omega-3 Index (8-11%).

The Pharmacokinetic Profile of a New Gastroresistant Capsule Preparation of Eicosapentaenoic Acid as the Free Fatty Acid

PubMed Central

Scaioli, Eleonora; Munarini, Alessandra; Hull, Mark A.; Belluzzi, Andrea

2015-01-01

Supplementation with n-3 polyunsaturated fatty acids (n-3 PUFAs) may be beneficial for patients with inflammatory bowel diseases (IBD). In this study we analyzed the pharmacokinetic profile of eicosapentaenoic acid (EPA), as the free fatty acid (FFA), in an enteric-coated preparation, in 10 ulcerative colitis (UC) and 10 Crohn's disease (CD) patients and 15 healthy volunteers (HV). Subjects received 2 g daily of EPA-FFA for 8 weeks. Plasma phospholipid and red blood cell (RBC) membrane fatty acid content were measured by gas chromatography-mass spectrometry. There was a rapid incorporation of EPA into plasma phospholipids by 2 weeks and a slower, but highly consistent, incorporation into RBC membranes (4% total fatty acid content; coefficient of variation 10–16%). There was a concomitant reduction in relative n-6 PUFA content. Elongation and desaturation of EPA into docosahexaenoic acid (DHA) via docosapentaenoic acid (DPA) were apparent and DHA content also increased in membranes. EPA-FFA is well tolerated and no difference in the pharmacokinetic profile of n-3 PUFA incorporation was detected between IBD patients and HV. Our data support the concept that EPA can be considered the “universal donor” with respect to key n-3 PUFAs and that this enteric-coated formulation allows long term treatment with a high level of compliance. PMID:26339608

A revised probabilistic estimate of the maternal methyl mercury intake dose corresponding to a measured cord blood mercury concentration.

PubMed

Stern, Alan H

2005-02-01

In 2001, the U.S. Environmental Protection Agency (EPA) adopted a revised reference dose (RfD) for methyl mercury (MeHg) of 0.1 microg/kg/day. The RfD is based on neurologic developmental effects measured in children associated with exposure in utero to MeHg from the maternal diet. The RfD derivation proceeded from a point of departure based on measured concentration of mercury in fetal cord blood (micrograms per liter). The RfD, however, is a maternal dose (micrograms per kilogram per day). Reconstruction of the maternal dose corresponding to this cord blood concentration, including the variability around this estimate, is a critical step in the RfD derivation. The dose reconstruction employed by the U.S. EPA using the one-compartment pharmacokinetic model contains two areas of significant uncertainty: It does not directly account for the influence of the ratio of cord blood: maternal blood Hg concentration, and it does not resolve uncertainty regarding the most appropriate central tendency estimates for pregnancy and third-trimester-specific model parameters. A probabilistic reassessment of this dose reconstruction was undertaken to address these areas of uncertainty and generally to reconsider the specification of model input parameters. On the basis of a thorough review of the literature and recalculation of the one-compartment model including sensitivity analyses, I estimated that the 95th and 99th percentiles (i.e., the lower 5th and 1st percentiles) of the maternal intake dose corresponding to a fetal cord blood Hg concentration of 58 microg/L are 0.3 and 0.2 microg/kg/day, respectively. For the 99th percentile, this is half the value previously estimated by the U.S. EPA.

Automotive advertising copy test. Final report. [Mileage estimates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The purpose of this research project was to explore the following issues: (1) mileage recall/recognition of miles per gallon/highway mileage estimates in print ads by advertisement readers; (2) determine consumer expectations and believability of advertised mileage guidelines; (3) measure recall/comprehension of mileage disclaimers; and (4) determine how consumers utilize published mileage estimates. The evidence from this study points to a public which is quite familiar with the EPA mileage estimates, in terms of using them as guidelines and in finding them to be helpful. Most adults also appear to be knowledgeable about factors which can affect car performance and, therefore,more » anticipate that, within certain tolerances, their actual mileage will differ from the EPA estimates. Although the consumer has been educated regarding fuel estimates, there is a very strong suggestion from this research that typical automobile print advertising does a less than an effective job in generating awareness of specific EPA estimates as well as their attendant disclaimer. Copy strategy and execution have a critical impact on recall of the EPA mileage estimates. 18 tables.« less

78 FR 67038 - FD&C Green No. 3; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... antimicrobial formulations, for use on food contact surfaces in public eating places, dairy processing equipment, and food processing equipment and utensils. The firm Exponent, on behalf of Ecolab submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of an...

76 FR 6347 - (S,S)-Ethylenediamine Disuccinic Acid Trisodium Salt; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... pesticide formulations applied to growing crops or to raw agricultural commodities after harvest under EPA... chelating agent in pesticide formulations applied to growing crops or to raw agricultural commodities after... pesticide formulations applied to growing crops or to raw agricultural commodities after harvest is safe...

76 FR 59901 - Isaria fumosorosea Apopka Strain 97; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... persist, it would not survive the conditions water is subjected to in wastewater treatment systems or... Classification System (NAICS) codes have been provided to assist you and others in determining whether this... notice of filing. Based upon review of the data supporting the petition, EPA has modified the...

76 FR 16308 - Dichlormid; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

..., stover; corn, pop, grain; corn, pop, stover; corn, sweet, forage; corn, sweet, kernel plus cob with husks... sweet corn forage, kernel plus cob with husks removed, and stover at 0.05 ppm. EPA has extended the..., sweet, forage; corn, sweet, kernel plus cob with husks removed; and corn, sweet, stover at 0.05 ppm...

77 FR 13499 - Fenamiphos; Data Call-in Order for Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... your identity or contact information unless you provide it in the body of your comment. If you send... electronically, EPA recommends that you include your name and other contact information in the body of your... timely fashion. Additional events that may be the basis for modification or revocation of fenamiphos...

77 FR 44151 - Titanium Dioxide; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-27

... napropamide, used in or on growing crops. United Phosphorus, Inc. submitted a petition to EPA under the... Phosphorus, Inc., 630 Freedom Business Center, Suite 402, King of Prussia, PA 19406. The petition requested... referenced a summary of the petition prepared by United Phosphorus, Inc., the petitioner, which is available...

75 FR 33190 - Trifloxystrobin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

....gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically, please go http://www.epa.gov/ocspp and select ``Test Methods and Guidelines.'' C. How Can I File an... (PP 8F7487) by Bayer CropScience, 2 T.W. Alexander Drive, P.O. Box 12014, Research Triangle Park, NC...

76 FR 17556 - Sodium Ferric Ethylenediaminetetraacetate; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-30

... Document provided as references in Unit IX. (Refs. 5 and 6). B. Biochemical Pesticide Human Health... snails. EPA assessed the risks to human health and concluded that, when sodium ferric EDTA was used in... human health from residues of sodium ferric EDTA in food crops. Furthermore, residues from the...

77 FR 30407 - 1,2-Ethanediamine, N

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... environment. 2. The polymer does contain as an integral part of its composition the atomic elements carbon... impurities, any element other than those listed in 40 CFR 723.250(d)(2)(ii). 4. The polymer is neither...

75 FR 760 - Choline chloride; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... addition to dietary consumption of choline and chloride, choline is made endogenously in the human body... and the relationship of this information to human risk. EPA has also considered available information... component of the human diet and acts as a precursor to acetylcholine, phospholipids, and the methyl donor...

75 FR 20785 - Polyglyceryl Phthalate Ester of Coconut Oil Fatty Acids; Exemption from the Requirement of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-21

...EPA issued a final rule in the Federal Register of July 8, 2009, concerning polyglyceryl phthalate ester of coconut oil fatty acids; exemption from the requirement of a tolerance. This document is being issued to correct the inert ingredient name and CAS numbers.

TOLERANCE AND GENETIC RELATEDNESS OF THREE MEIOBENTHIC COPEPOD POPULATIONS EXPOSED TO SEDIMENT-ASSOCIATED CONTAMINANT MIXTURES: ROLE OF ENVIRONMENTAL HISTORY. (R825439)

EPA Science Inventory

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

76 FR 12873 - Potassium Benzoate; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... (preservative) in pesticide formulations applied pre- and post-harvest. In the Federal Register of June 4, 2008... the relationship of the results of the studies to human risk. EPA has also considered available... were non-sensitizing in animal tests but showed a very low incidence of sensitization in humans patch...

76 FR 20537 - Etoxazole; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA..., identified by docket ID number EPA-HQ-OPP-2010-0063, by one of the following methods: Federal eRulemaking...), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA...

76 FR 59909 - Amisulbrom; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

....regulations.gov , or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. S-4400, One..., identified by docket ID number EPA-HQ-OPP-2010-0186, by one of the following methods: Federal eRulemaking...), Environmental Protection Agency, Rm. S-4400, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA...

77 FR 39962 - Difenzoquat; Proposed Data Call-in Order for Pesticide Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... wheat (40 CFR 180.369). Since there are currently no domestic registrations for difenzoquat, these...; residue data for wheat hay, wheat forage, and barley hay; and an immunotoxicity study. These data [[Page... Field Trials (860.1500)--(wheat hay, wheat forage, and barley hay) Rationale. EPA does not have crop...

Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line.

PubMed

Dyr, Wanda; Taracha, Ewa

2012-01-01

The development of tolerance to alcohol with chronic consumption is an important criterion for an animal model of alcoholism and may be an important component of the genetic predisposition to alcoholism. The aim of this study was to determine whether the selectively bred Warsaw High Preferring (WHP) line of alcohol-preferring rats would develop behavioral and metabolic tolerance during the free-choice drinking of ethanol. Chronic tolerance to ethanol-induced sedation was tested. The loss of righting reflex (LRR) paradigm was used to record sleep duration in WHP rats. Ethanol (EtOH)-naive WHP rats received a single intraperitoneal (i.p.) injection of 5.0 g ethanol/kg body weight (b.w.), and sleep duration was measured. Subsequently, rats had access to a 10% ethanol solution under a free-choice condition with water and food for 12 weeks. After 12 weeks of the free-choice intake of ethanol, the rats received another single i.p. injection of 5.0 g ethanol/kg b.w., and sleep duration was reassessed. The blood alcohol content (BAC) for each rat was determined after an i.p. injection of 5 g/kg of ethanol in naive rats and again after chronic alcohol drinking at the time of recovery of the righting reflex (RR). The results showed that the mean ethanol intake was 9.14 g/kg/24 h, and both sleep duration and BAC were decreased after chronic ethanol intake. In conclusion, WHP rats exposed to alcohol by free-choice drinking across 12 weeks exhibited increased alcohol elimination rates. Studies have demonstrated that WHP rats after chronic free-choice drinking (12 weeks) of alcohol develop metabolic tolerance. Behavioral tolerance to ethanol was demonstrated by reduced sleep duration, but this decrease in sleep duration was not significant.

Performance of toxicity probability interval based designs in contrast to the continual reassessment method

PubMed Central

Horton, Bethany Jablonski; Wages, Nolan A.; Conaway, Mark R.

2016-01-01

Toxicity probability interval designs have received increasing attention as a dose-finding method in recent years. In this study, we compared the two-stage, likelihood-based continual reassessment method (CRM), modified toxicity probability interval (mTPI), and the Bayesian optimal interval design (BOIN) in order to evaluate each method's performance in dose selection for Phase I trials. We use several summary measures to compare the performance of these methods, including percentage of correct selection (PCS) of the true maximum tolerable dose (MTD), allocation of patients to doses at and around the true MTD, and an accuracy index. This index is an efficiency measure that describes the entire distribution of MTD selection and patient allocation by taking into account the distance between the true probability of toxicity at each dose level and the target toxicity rate. The simulation study considered a broad range of toxicity curves and various sample sizes. When considering PCS, we found that CRM outperformed the two competing methods in most scenarios, followed by BOIN, then mTPI. We observed a similar trend when considering the accuracy index for dose allocation, where CRM most often outperformed both the mTPI and BOIN. These trends were more pronounced with increasing number of dose levels. PMID:27435150

Safety interventions on the labor and delivery unit.

PubMed

Kacmar, Rachel M

2017-06-01

The present review highlights recent advances in efforts to improve patient safety on labor and delivery units and well tolerated care for pregnant patients in general. Recent studies in obstetric patient safety have a broad focus but repetitive themes for interdisciplinary training include: simulating critical events, having open multidisciplinary communication, frequent reviews of cases of maternal morbidity, and implementing maternal early warning systems. The National Partnership for Maternal Safety is also active in promoting care bundles across many topics on maternal safety. A culture of safety is the goal for all obstetric units. Achieving that ideal requires multidisciplinary collaboration, frequent reassessment for areas of improvement, and a culture of openness to change when improvement opportunities arise.

Effects of Food on the Pharmacokinetics of Omega-3-Carboxylic Acids in Healthy Japanese Male Subjects: A Phase I, Randomized, Open-label, Three-period, Crossover Trial.

PubMed

Shimada, Hitoshi; Nilsson, Catarina; Noda, Yoshinori; Kim, Hyosung; Lundström, Torbjörn; Yajima, Toshitaka

2017-09-01

Omega-3-carboxylic acids (OM3-CA) contain omega-3 free fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as carboxylic acids. Food intake is known to affect the bioavailability of ethyl ester fatty acid formulations. We conducted a phase I study to investigate the effects of the timing of OM3-CA administration relative to food intake on the pharmacokinetics of EPA and DHA. In this randomized, open-label, three-period crossover study, Japanese healthy male subjects were administered 4×1 g OM3-CA capsules with continued fasting, before a meal, or after a meal. All subjects fasted for ≥10 h prior to drug/meal administration. The primary objective was to examine the effect of meal timing on the pharmacokinetics of EPA and DHA after OM3-CA administration. The secondary objectives were to examine the safety and tolerability of OM3-CA. A total of 42 Japanese subjects was enrolled in the study. The baseline-adjusted maximum concentration and area under the concentration-time curve from 0 to 72 h for EPA, DHA, and EPA +DHA were lower in the fasting and before meal conditions than in the after meal condition. The maximum total EPA, total DHA, and total EPA+DHA concentrations were reached later when administered in fasting conditions than in fed conditions, indicating slower absorption in fasting conditions. Diarrhea was reported by five, six, and no subjects in the fasting, before meal, and after meal conditions, respectively. The timing of OM3-CA administration relative to food intake influences the systemic bioavailability of EPA and DHA in healthy Japanese male subjects. NCT02372344.

Prioritization of pesticides based on daily dietary exposure potential as determined from the SHEDS model.

PubMed

Melnyk, Lisa Jo; Wang, Zhaohui; Li, Zhilin; Xue, Jianping

2016-10-01

A major pathway for exposure to many pesticides is through diet. The objectives were to rank pesticides by comparing their calculated daily dietary exposure as determined by EPA's Stochastic Human Exposure and Dose Simulation (SHEDS) to single pesticides for different age groups to acceptable daily intakes (ADI), characterize pesticide trends in exposures over different time periods, and determine commodities contributing to pesticide exposures. SHEDS was applied, using Pesticide Data Program (PDP) (1991-2011) and pesticide usage data on crops from USDA combined with NHANES dietary consumption data, to generate exposure estimates by age group. ADI data collected from EPA, WHO, and other sources were used to rank pesticides based on relativeness of the dietary exposure potential to ADI by age groups. Sensitivity analysis provided trends in pesticide exposures. Within SHEDS, commodities contributing the majority of pesticides with greatest exposure potential were determined. The results indicated that the highest ranking pesticides were methamidophos and diazinon which exceeded 100% of the ADI. Sensitivity analysis indicated that exposure to methamidophos, diazinon, malathion, ethion and formetanate hydrochloride had a marked decrease from 1991-1999 to 2000-2011. Contributions analysis indicated that apples, mushroom, carrots, and lettuce contributed to diazinon exposure. Beans and pepper contributed to methamidophos exposure. Published by Elsevier Ltd.

Understanding Sediment Processes of Los Laureles Canyon in the Binational Tijuana River Watershed

NASA Astrophysics Data System (ADS)

Yuan, Yongping; Biggs, Trent; Liden, Douglas

2015-04-01

Tijuana River Basin originates in Mexico and drains 4465 km2 into the Tijuana River Estuary National Research Reserve, a protected coastal wetland in California that supports 400 species of birds. Excessive erosion in Tijuana during storms produces sediment loads that bury native vegetation and block the tidal channels. Erosion also threatens human life, causing roads and houses in Mexico to collapse and the Tijuana River Valley in the U.S. to flood. Government agencies in US and Mexico spend millions annually to remove sediment. The EPA-SEMARNAT Border 2020 program identified the reduction of sediment to the Tijuana Estuary as a high priority. Gully formation on unpaved roads, channel erosion, and sheetwash and rill erosion from vacant lots in Tijuana are the primary sources of sediment (Biggs et al, 2009). Because 73% of the watershed is located in Mexico, the problem is likely to worsen as Tijuana continues to urbanize. EPA, with support from USDA, San Diego State University, and CICESE, is developing a model to estimate the sediment loss from a sub-basin of the watershed (Los Laureles Canyon) under existing conditions and under future development. This study will evaluate the reduction/prevention of sediment loss from green infrastructure projects, sediment basins, road paving, and conservation easements.

75 FR 11173 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... Pesticide Petitions Filed for Residues of Pesticide Chemicals in or on Various Commodities; Correction... identification No. EPA-HQ-OPP-2009-0980 proposing to establish import tolerances in 40 CFR part 180 for residues of the ``insecticide'' fluazifop-p-butyl in various potato commodities. This document is being issued...

78 FR 7266 - Alpha-Cypermethrin; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-01

... confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. Submit the non...- cypermethrin in or on tree nuts, Group 14; dried shelled pea and bean, except soybean, subgroup 6C; corn, grain... shelled pea and bean, subgroup 6B; and root and tuber vegetables, Group 1 at 0.1 ppm; cucurbit vegetables...

77 FR 47287 - Bacillus thuringiensis eCry3.1Ab Protein in Corn; Exemption From the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-08

..., is available either electronically through http://www.regulations.gov or in hard copy at the OPP... instructions and additional information about the docket available at http://www.epa.gov/dockets . FOR FURTHER... methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the online instructions for...

77 FR 15015 - Revocation of Tolerance Exemptions for Diethyl Phthalate and Methyl Ethyl Ketone; No Data Being...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

... use of profanity or personal threats. viii. Make sure to submit your comments by the comment period... when used as inert ingredients in pesticide products because there are insufficient data to make the..., 2012. ADDRESSES: Submit your comments, identified by docket identification (ID) number EPA-HQ-OPP-2011...

75 FR 4274 - Novaluron; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... at 0.50 parts per million (ppm); Swiss chard at 12 ppm; bean, snap, succulent at 0.60 ppm; bean, dry...; bean, dry, seed at 0.30 ppm; and Swiss chard at 12 ppm. EPA's assessment of exposures and risks.... Novaluron has low acute toxicity via the oral, dermal and inhalation routes of exposure. It is not an eye or...

76 FR 69659 - Methacrylic Acid-Methyl Methacrylate-Polyethylene Glycol Monomethyl Ether Methacrylate Graft...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... in residential settings. If EPA is able to determine that a finite tolerance is not necessary to... elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d)(2)(ii). 4. The...

75 FR 43076 - 2-Propanol, 1,1′,1′′-nitrilotris-; Exemption from the Requirement of a Tolerance

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-23

.../kg/day). Three mutagenicity studies (Ames test, mammalian gene mutation, and chromosome aberration...- and post-harvest. Dow AgroSciences, LLC submitted a petition to EPA under the Federal Food, Drug, and....gpoaccess.gov/ecfr . To access the harmonized test guidelines referenced in this document electronically...

77 FR 12740 - Trinexapac-ethyl; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... CGA-179500, in or on grass, forage, grown for seed at 1.60 parts per million (ppm); grass, hay, grown for seed at 3.5 ppm; grass, seed screenings, grown for seed at 45.0 ppm; grass, straw, grown for seed..., Sugarcane, and Grasses Grown for Seed'' p. 48 in docket ID number EPA-HQ-OPP-2010-0524. B. Toxicological...

Benefit-risk reassessment of medicines: a retrospective analysis of all safety-related referral procedures in Europe during 2001-2012.

PubMed

Bouvy, Jacoline C; Huinink, Lotte; De Bruin, Marie L

2016-09-01

The aim of this study was to determine the outcomes and timing within the product life cycle of all benefit-risk reassessment procedures for marketed products that were completed by the committee for medicinal product for human use during 2001-2012. A cohort of all referral procedures for benefit-risk reassessment (Article 20, Article 31, Article 36, Article 107 procedures) for which committee for medicinal product for human use issued an opinion between 1 January 2001 and 31 December 2012 was created. The European Medicines Agency website and the Dutch Medicines Evaluation Board website were used to collect all data. There were a total of 73 benefit-risk reassessments during the study period; 61 reassessments for a single product and 12 reassessments for multiple products or an entire product class. Nineteen reassessments resulted in the recommendation to remove the product from the market. On average, a benefit-risk reassessment was performed 18.7 years after the product was first marketed. Seventeen products were marketed 5 years or less when the reassessment procedure was completed; six of these products were subsequently removed from the market. The majority of all benefit-risk reassessments that were performed during the study period did not result in removing the product from the market, but rather, in confirming the positive benefit-risk of the product, conditional to changes to the product's marketing authorisation. About half of all products that were removed from the market during the 2000s had been marketed for more than 20 years. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

7 CFR 62.209 - Reassessment.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AGRICULTURAL COMMODITIES (QUALITY SYSTEMS VERIFICATION PROGRAMS) Quality Systems Verification Programs Definitions Service § 62.209 Reassessment. Approved programs are subject to periodic reassessments to ensure...

Registration of USDA-UTWH-102 winter hardy orchardgrass germplasm

USDA-ARS?s Scientific Manuscript database

The USDA-ARS announces the release of USDA-UTWG-102 orchardgrass (Dactylis glomerata L.) (Reg. No., PI) germplasm. USDA-UTWH-102 possesses increased winter hardiness and provides utility to applied orchardgrass breeding and genetic programs. USDA-UTWH-102 is a 24 clone synthetic derived from orchard...

The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD).

PubMed

Spies, Jonas Willian; Valera, Fabiana Cardoso Pereira; Cordeiro, Daniel Loiola; de Mendonça, Taís Nociti; Leite, Marcelo Gonçalves Junqueira; Tamashiro, Edwin; Arruda, Luiza Karla; Anselmo-Lima, Wilma Terezinha

2016-01-01

Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options. To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD. Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized. Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up. Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response. Copyright © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

A Novel ω-3 Acid Ethyl Ester Formulation Incorporating Advanced Lipid TechnologiesTM (ALT®) Improves Docosahexaenoic Acid and Eicosapentaenoic Acid Bioavailability Compared with Lovaza®.

PubMed

Lopez-Toledano, Miguel A; Thorsteinsson, Thorsteinn; Daak, Ahmed; Maki, Kevin C; Johns, Colleen; Rabinowicz, Adrian L; Sancilio, Frederick D

2017-03-01

The US Food and Drug Administration has approved several highly purified ω-3 fatty acid prescription drugs for the treatment of severe hypertriglyceridemia. These differ in the amounts and forms of docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). This study compared the bioavailability of SC401 (1530 mg EPA-ethyl esters [EEs] and DHA-EEs plus Advanced Lipid Technologies ⁎ [ALT † ], a proprietary lipid-delivery platform to improve absorption), with. Lovaza ‡ (3600 mg ω-3, primarily EPA-EEs and DHA-EEs) under low-fat feeding conditions. This was a Phase I, randomized, open-label, single-dose, 2-way crossover study in healthy participants housed from day -3 to day 2 in each treatment period. Blood samples for pharmacokinetic measurements were collected before and after dosing, and safety profile and tolerability were assessed. In unadjusted analyses, SC401 had 5% lower C max and approximately the same AUC 0-last of EPA + DHA total lipids compared with Lovaza. When adjusted for baseline, SC401 had ~6% higher C max and 18% higher AUC 0-last for EPA + DHA total lipids, and dose- and baseline-adjusted analyses found that SC401 had ~149% higher C max and 178% higher AUC 0-last than Lovaza for EPA + DHA total lipids. The T max was also substantially longer with Lovaza (~10 hours) than with SC401 (~6 hours). These results indicate that SC401, an ω-3 acid EE formulation containing ALT † achieved high bioavailability of EPA and DHA, at a lower dose (1530 mg) than Lovaza (3600 mg), under low-fat feeding conditions. Copyright © 2017 Elsevier HS Journals, Inc. All rights reserved.

77 FR 25903 - Thiamethoxam; Pesticide Tolerances; Technical Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

...; safflower, seed; and nut, tree, group 14. DATES: This final rule is effective May 2, 2012. ADDRESSES: EPA...; nut, tree, group 14 at 0.02 ppm; onion, dry bulb at 0.03 ppm; papaya at 0.40 ppm; and safflower, seed..., dry bulb; papaya; safflower, seed; and nut, tree, group 14 to the table in paragraph (a) to read as...

75 FR 78240 - Notice of Receipt of Several Pesticide Petitions Filed for Residues of Pesticide Chemicals in or...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-15

..., proposes to establish a tolerance in 40 CFR part 180 for residues of the fungicide flutriafol, [( )-[alpha]-(2-fluorophenyl)-[alpha]- (4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol], including its metabolites... has been submitted to the Agency. Contact: Lisa Jones, (703) 308-9424; e-mail address: jones.lisa@epa...

75 FR 50926 - 2-propenoic acid, 2-methyl-, C12-16-alkyl esters, telomers with 1-dodecanethiol, polyethylene...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in...

76 FR 7703 - 1,4-Benzenedicarboxylic Acid, Dimethyl Ester, Polymer With 1,4-Butanediol, Adipic Acid, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... part of its composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed...

78 FR 76567 - Tall Oil, Polymer With Polyethylene Glycol and Succinic Anhydride Monopolyisobutylene Derivs...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d)(2)(ii). 4. The...

77 FR 20314 - 2-Propenoic Acid, 2-Methyl-, 2-Ethylhexyl Ester, Telomer With 1-Dodecanethiol, Ethenylbenzene and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

... result of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is... composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d...

DETERMINATION OF THE APPROPRIATE FQPA SAFETY FACTOR(S) IN THE ORGANOPHOSPHOROUS PESTICIDE CUMULATIVE RISK ASSESSMENT: SUSCEPTIBILITY AND SENSITIVITY TO THE COMMON MECHANISM, ACETYLCHOLINESTERASE INHIBITION

EPA Science Inventory

The Food Quality Protection Act of 1996 (FQPA) directs EPA, in setting pesticide tolerances, to use an additional tenfold margin of safety to protect infants and children taking into account the potential for pre- and postnatal toxicity and the completeness of the toxicology and ...

Final Rule for Control of Air Pollution From New Motor Vehicles and New Motor Vehicle Engines: Evaporative and Refueling Emission Regulations for Gasolineand Methanol-Fueled Light-Duty Vehicles and Light-Duty Trucks and Heavy-Duty Vehicles; Technical Amen

EPA Pesticide Factsheets

On March 24, 1993 EPA finalized a new test procedure to measure evaporative emissions from motor vehicles. The amendments modify several of the test procedure’s tolerances, equipment specifications, and procedural steps.

Science Symposia to Reassess the Science of Hypoxia

EPA Pesticide Factsheets

Four symposia were conducted as part of the Reassessment with the purpose of assessing the current state of the science of hypoxia. An additional workshop on the science of nutrients in the Mississippi River Basin contributed to the reassessment.

Variation in soil aluminium tolerance genes is associated with local adaptation to soils at the Park Grass Experiment.

PubMed

Gould, Billie; McCouch, Susan; Geber, Monica

2014-12-01

Studies of the wild grass Anthoxanthum odoratum at the long-term Park Grass Experiment (PGE, Harpenden, UK) document a well-known example of rapid plant evolution in response to environmental change. Repeated fertilizer applications have acidified the soil in some experimental plots over the past 150+ years, and Anthoxanthum subpopulations have quickly become locally adapted. Early reciprocal transplants showed subpopulation differentiation specifically in response to soil aluminium (Al) toxicity across the experiment, even at small (30 m) spatial scales. Almost 40 years after its original measurement, we reassessed the degree of local adaptation to soil Al at the PGE using updated phenotyping methods and identified genes with variation linked to the tolerance trait. Root growth assays show that plants are locally adapted to soil Al at both the seedling and adult growth stages, but to a smaller extent than previously inferred. Among a large suite of candidate loci that were previously shown to have Al-sensitive expression differences between sensitive and tolerant plants, three loci contained SNPs that are associated with both Al tolerance and soil acidity: an Al-sensitive malate transporter (ALMT), a tonoplast intrinsic protein (TIP) and the putative homolog of the rice cell-wall modification gene STAR1. Natural genetic variation at these loci is likely to have contributed to the recent rapid evolution at PGE. Continued study of Al tolerance variants in Anthoxanthum will allow us to test hypotheses about the nature and source of genetic variation that enables some species to adapt to soil acidification and other types of rapid environmental change. © 2014 John Wiley & Sons Ltd.

7 CFR 170.12 - What are the selection criteria for participation in the USDA Farmers Market?

Code of Federal Regulations, 2013 CFR

2013-01-01

... the USDA Farmers Market? 170.12 Section 170.12 Agriculture Regulations of the Department of... OF 1946 USDA FARMERS MARKET § 170.12 What are the selection criteria for participation in the USDA.... Participants should commit to supporting the USDA food gleaning/food recovery initiative. This commitment...

7 CFR 170.12 - What are the selection criteria for participation in the USDA Farmers Market?

Code of Federal Regulations, 2012 CFR

2012-01-01

... the USDA Farmers Market? 170.12 Section 170.12 Agriculture Regulations of the Department of... OF 1946 USDA FARMERS MARKET § 170.12 What are the selection criteria for participation in the USDA.... Participants should commit to supporting the USDA food gleaning/food recovery initiative. This commitment...

7 CFR 170.12 - What are the selection criteria for participation in the USDA Farmers Market?

Code of Federal Regulations, 2014 CFR

2014-01-01

... the USDA Farmers Market? 170.12 Section 170.12 Agriculture Regulations of the Department of... OF 1946 USDA FARMERS MARKET § 170.12 What are the selection criteria for participation in the USDA.... Participants should commit to supporting the USDA food gleaning/food recovery initiative. This commitment...

Alfalfa (Medicago sativa L.) is tolerant to higher levels of salinity than previous guidelines indicated: Implications of field and greenhouse studies

NASA Astrophysics Data System (ADS)

Putnam, Daniel H.; Benes, Sharon; Galdi, Giuliano; Hutmacher, Bob; Grattan, Steve

2017-04-01

Alfalfa (Medicago sativa L.) is the most widely grown leguminous forage crop in North America and is valued for high productivity, quality, economic value, and for dairy productivity. Alfalfa has historically been classified as moderately sensitive to saline conditions, with yield declines predicted at >2 dS/m in the saturated soil paste extract. However, greenhouse, sand tank, and field studies over the past five years have confirmed that alfalfa can be grown with limited negative effects at much higher salinity levels. A broad collection of alfalfa varieties has exhibited a range of resistance at irrigation water salinities >5 dS/m ECw in greenhouse trials, with significant variation due to variety. USDA-ARS sand tank studies indicated similar or greater tolerances closer to 8 dS/m in the soil water, in addition to confirmation of significant varietal differences. A three-year field study on clay loam soil with applications of 5-7 dS/m ECw irrigation water indicated normal yields and excellent stand survivability. A second field study in the same soil type with levels from 8-10 dS/m ECw showed yield reductions of 10-15% but economic yields were still achieved at those levels. Field and greenhouse studies were conducted with mixed salt saline sodic waters typical of the San Joaquin Valley of California. Field evaluation of variety performance was subject to greater variation due to secondary salinity-soil interactions including water infiltration and crusting problems, not only salinity per-se. Thus, adequate irrigation water availability to the crop may be as important as salinity in impacting yields under field conditions. Once established, the deep-rooted characteristics of alfalfa enable utilization of deeper subsurface moisture, even at moderate to high salinity levels, as documented by USDA lysimeter studies. Significant advantages to salinity-tolerant varieties have been observed. It will be important to consider specific management factors which may enable the successful production of irrigated alfalfa with use of saline (up to 8 dS/m ECw) irrigation water, including careful water management during stand establishment, prevention of crusting, and agronomic practices to promote water infiltration. Irrigated regions looking for economically-viable crop species to grow under saline conditions may consider alfalfa grown utilizing appropriate methodologies, including salt-tolerant varieties and agronomic practices to mitigate the secondary effects of soil salinity and sodicity.

Work Plan for a Limited CCC/USDA Investigation of the Current Carbon Tetrachloride Contamination in Groundwater at Navarre, Kansas

DOE Office of Scientific and Technical Information (OSTI.GOV)

LaFreniere, Lorraine M.

During private well testing in 1990-1991, carbon tetrachloride was identified in the groundwater at several locations in the town of Navarre, Kansas, at levels exceeding the Kansas Tier 2 level and U.S. Environmental Protection Agency (EPA) maximum contaminant level (MCL) of 5.0 μg/L. Several subsequent investigations through 2006 evaluated the concentrations and distribution of carbon tetrachloride in groundwater. This work included the identification of the contaminant sources (Argonne 2007). The history of activities to address the contamination in soil and groundwater is summarized in Table 1.1. The most recent studies, conducted by the Kansas Department of Health and Environment (KDHE),more » include a brownfields investigation initiated in 2013 (Phase I) and continuing in early 2014 (Phase II), as well as private well testing.« less

Developing U.S. oversight strategies for nanobiotechnology: learning from past oversight experiences.

PubMed

Paradise, Jordan; Wolf, Susan M; Kuzma, Jennifer; Kuzhabekova, Aliya; Tisdale, Alison W; Kokkoli, Efrosini; Ramachandran, Gurumurthy

2009-01-01

The emergence of nanotechnology, and specifically nanobiotechnology, raises major oversight challenges. In the United States, government, industry, and researchers are debating what oversight approaches are most appropriate. Among the federal agencies already embroiled in discussion of oversight approaches are the Food and Drug Administration (FDA), Environmental Protection Agency (EPA), Department of Agriculture (USDA), Occupational Safety and Health Administration (OSHA), and National Institutes of Health (NIH). All can learn from assessment of the successes and failures of past oversight efforts aimed at emerging technologies. This article reports on work funded by the National Science Foundation (NSF) aimed at learning the lessons of past oversight efforts. The article offers insights that emerge from comparing five oversight case studies that examine oversight of genetically engineered organisms (GEOs) in the food supply, pharmaceuticals, medical devices, chemicals in the workplace, and gene therapy. Using quantitative and qualitative analysis, the authors present a new way of evaluating oversight.

A Transgenic Camelina sativa Seed Oil Effectively Replaces Fish Oil as a Dietary Source of Eicosapentaenoic Acid in Mice123

PubMed Central

Tejera, Noemi; Vauzour, David; Betancor, Monica B; Sayanova, Olga; Usher, Sarah; Cochard, Marianne; Rigby, Neil; Ruiz-Lopez, Noemi; Menoyo, David; Tocher, Douglas R; Napier, Johnathan A; Minihane, Anne Marie

2016-01-01

Background: Fish currently supplies only 40% of the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) required to allow all individuals globally to meet the minimum intake recommendation of 500 mg/d. Therefore, alternative sustainable sources are needed. Objective: The main objective was to investigate the ability of genetically engineered Camelina sativa (20% EPA) oil (CO) to enrich tissue EPA and DHA relative to an EPA-rich fish oil (FO) in mammals. Methods: Six-week-old male C57BL/6J mice were fed for 10 wk either a palm oil–containing control (C) diet or diets supplemented with EPA-CO or FO, with the C, low-EPA CO (COL), high-EPA CO (COH), low-EPA FO (FOL), and high-EPA FO (FOH) diets providing 0, 0.4, 3.4, 0.3, and 2.9 g EPA/kg diet, respectively. Liver, muscle, and brain were collected for fatty acid analysis, and blood glucose and serum lipids were quantified. The expression of selected hepatic genes involved in EPA and DHA biosynthesis and in modulating their cellular impact was determined. Results: The oils were well tolerated, with significantly greater weight gain in the COH and FOH groups relative to the C group (P < 0.001). Significantly lower (36–38%) blood glucose concentrations were evident in the FOH and COH mice relative to C mice (P < 0.01). Hepatic EPA concentrations were higher in all EPA groups relative to the C group (P < 0.001), with concentrations of 0.0, 0.4, 2.9, 0.2, and 3.6 g/100 g liver total lipids in the C, COL, COH, FOL, and FOH groups, respectively. Comparable dose-independent enrichments of liver DHA were observed in mice fed CO and FO diets (P < 0.001). Relative to the C group, lower fatty acid desaturase 1 (Fads1) expression (P < 0.005) was observed in the COH and FOH groups. Higher fatty acid desaturase 2 (Fads2), peroxisome proliferator–activated receptor α (Ppara), and peroxisome proliferator–activated receptor γ (Pparg) (P < 0.005) expressions were induced by CO. No impact of treatment on liver X receptor α (Lxra) or sterol regulatory element-binding protein 1c (Srebp1c) was evident. Conclusions: Oil from transgenic Camelina is a bioavailable source of EPA in mice. These data provide support for the future assessment of this oil in a human feeding trial. PMID:26791554

2 CFR 417.221 - How would the exclusions from coverage for the USDA's foreign assistance programs apply?

Code of Federal Regulations, 2011 CFR

2011-01-01

... the USDA's foreign assistance programs apply? 417.221 Section 417.221 Grants and Agreements Federal... SUSPENSION Covered Transactions § 417.221 How would the exclusions from coverage for the USDA's foreign... into between USDA and a program participant, such as a U.S. private voluntary organization. USDA would...

7 CFR 170.4 - Who may participate in the USDA Farmers Market?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false Who may participate in the USDA Farmers Market? 170.4... MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.4 Who may participate in the USDA Farmers Market? Members of three groups may participate in the USDA Farmers Markets...

7 CFR 170.11 - How are farmers and vendors selected for participation in the USDA Farmers Market?

Code of Federal Regulations, 2014 CFR

2014-01-01

... in the USDA Farmers Market? 170.11 Section 170.11 Agriculture Regulations of the Department of... OF 1946 USDA FARMERS MARKET § 170.11 How are farmers and vendors selected for participation in the USDA Farmers Market? USDA reviews all applications and selects participants based primarily on the type...

2 CFR 417.221 - How would the exclusions from coverage for the USDA's foreign assistance programs apply?

Code of Federal Regulations, 2013 CFR

2013-01-01

... the USDA's foreign assistance programs apply? 417.221 Section 417.221 Grants and Agreements Federal... SUSPENSION Covered Transactions § 417.221 How would the exclusions from coverage for the USDA's foreign... into between USDA and a program participant, such as a U.S. private voluntary organization. USDA would...

2 CFR 417.221 - How would the exclusions from coverage for the USDA's foreign assistance programs apply?

Code of Federal Regulations, 2014 CFR

2014-01-01

... the USDA's foreign assistance programs apply? 417.221 Section 417.221 Grants and Agreements Federal... SUSPENSION Covered Transactions § 417.221 How would the exclusions from coverage for the USDA's foreign... into between USDA and a program participant, such as a U.S. private voluntary organization. USDA would...

7 CFR 170.4 - Who may participate in the USDA Farmers Market?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false Who may participate in the USDA Farmers Market? 170.4... MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.4 Who may participate in the USDA Farmers Market? Members of three groups may participate in the USDA Farmers Markets...

7 CFR 170.11 - How are farmers and vendors selected for participation in the USDA Farmers Market?

Code of Federal Regulations, 2012 CFR

2012-01-01

... in the USDA Farmers Market? 170.11 Section 170.11 Agriculture Regulations of the Department of... OF 1946 USDA FARMERS MARKET § 170.11 How are farmers and vendors selected for participation in the USDA Farmers Market? USDA reviews all applications and selects participants based primarily on the type...

7 CFR 170.11 - How are farmers and vendors selected for participation in the USDA Farmers Market?

Code of Federal Regulations, 2013 CFR

2013-01-01

... in the USDA Farmers Market? 170.11 Section 170.11 Agriculture Regulations of the Department of... OF 1946 USDA FARMERS MARKET § 170.11 How are farmers and vendors selected for participation in the USDA Farmers Market? USDA reviews all applications and selects participants based primarily on the type...

2 CFR 417.221 - How would the exclusions from coverage for the USDA's foreign assistance programs apply?

Code of Federal Regulations, 2012 CFR

2012-01-01

... the USDA's foreign assistance programs apply? 417.221 Section 417.221 Grants and Agreements Federal... SUSPENSION Covered Transactions § 417.221 How would the exclusions from coverage for the USDA's foreign... into between USDA and a program participant, such as a U.S. private voluntary organization. USDA would...

7 CFR 170.4 - Who may participate in the USDA Farmers Market?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false Who may participate in the USDA Farmers Market? 170.4... MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.4 Who may participate in the USDA Farmers Market? Members of three groups may participate in the USDA Farmers Markets...

7 CFR 170.4 - Who may participate in the USDA Farmers Market?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false Who may participate in the USDA Farmers Market? 170.4... MARKETING PRACTICES UNDER THE AGRICULTURAL MARKETING ACT OF 1946 USDA FARMERS MARKET § 170.4 Who may participate in the USDA Farmers Market? Members of three groups may participate in the USDA Farmers Markets...

75 FR 17645 - Polychlorinated Biphenyls (PCBs); Reassessment of Use Authorizations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... reassessing the definitions of ``excluded manufacturing process,'' ``quantifiable level/level of detection... reassessing the definitions of ``excluded manufacturing process,'' ``quantifiable level/level of detection... to authorize by rule the manufacturing, processing, distribution in commerce, and use of PCBs in a...

76 FR 66601 - Revision of Delegations of Authority

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... specific laws and regulations, and excluding the Official USDA Seal and Official USDA Symbol. DATES: This... USDA Seal and Official USDA Symbol. * * * * * Signed in Washington, DC, on October 21, 2011. Thomas J...

USDA snack food and beverage standards: how big of a stretch for the states?

PubMed

Chriqui, Jamie F; Piekarz, Elizabeth; Chaloupka, Frank J

2014-06-01

The USDA snack food and beverage standards take effect in school year (SY) 2014-2015. Although the USDA standards will provide nationwide requirements, concerns exist about compliance. This study examined whether existing state laws are aligned with the USDA standards to determine whether some states may be better positioned to facilitate compliance. Codified state statutory and regulatory laws effective for SY 2012-2013 for each of the 50 states and the District of Columbia were identified through Boolean keyword searches using the Westlaw and LexisNexis databases. Laws were analyzed for alignment with 18 snack food and beverage provisions contained within the USDA standards. Thirty-eight states had snack food and beverage standards; 33 states' laws exceeded restrictions on foods of minimal nutritional value. Of the 33 states, no states' laws fully met the USDA's standards, 16 states' laws fully met and 10 states' laws partially met at least one USDA provision, and seven states' laws met no USDA provisions. One state's law met 9 of 18 provisions. On average, states met 4 of 18 provisions. States were more likely to meet individual USDA beverage than snack provisions. Implementation and compliance with the USDA standards may be facilitated in states with laws already containing provisions aligned with the USDA standards and may be more difficult in states with fewer or no provisions in alignment, suggesting possible geographic areas for the USDA to target with technical assistance and training efforts and for advocates to work in to facilitate compliance.

ACToR Chemical Structure processing using Open Source ...

EPA Pesticide Factsheets

ACToR (Aggregated Computational Toxicology Resource) is a centralized database repository developed by the National Center for Computational Toxicology (NCCT) at the U.S. Environmental Protection Agency (EPA). Free and open source tools were used to compile toxicity data from over 1,950 public sources. ACToR contains chemical structure information and toxicological data for over 558,000 unique chemicals. The database primarily includes data from NCCT research programs, in vivo toxicity data from ToxRef, human exposure data from ExpoCast, high-throughput screening data from ToxCast and high quality chemical structure information from the EPA DSSTox program. The DSSTox database is a chemical structure inventory for the NCCT programs and currently has about 16,000 unique structures. Included are also data from PubChem, ChemSpider, USDA, FDA, NIH and several other public data sources. ACToR has been a resource to various international and national research groups. Most of our recent efforts on ACToR are focused on improving the structural identifiers and Physico-Chemical properties of the chemicals in the database. Organizing this huge collection of data and improving the chemical structure quality of the database has posed some major challenges. Workflows have been developed to process structures, calculate chemical properties and identify relationships between CAS numbers. The Structure processing workflow integrates web services (PubChem and NIH NCI Cactus) to d

“Nitrogen Budgets for the Mississippi River Basin using the ...

EPA Pesticide Factsheets

Presentation on the results from the 3 linked models, EPIC (USDA), CMAQ and NEWS to analyze a scenario of increased corn production related to biofuels together with Clean Air Act emission reductions across the US and the resultant effect on nitrogen loading to the Gulf of Mexico from the Mississippi River Basin. This is a demonstration of a capability to connect the N cascade bringing air, land, water together. EPIC = Environmental Policy Integrated Climate model, CMAQ = Community Multiscale Air Quality model, NEWS = Nutrient Export of WaterSheds model. The National Exposure Research Laboratory (NERL) Atmospheric Modeling and Analysis Division (AMAD) conducts research in support of EPA mission to protect human health and the environment. AMAD research program is engaged in developing and evaluating predictive atmospheric models on all spatial and temporal scales for forecasting the air quality and for assessing changes in air quality and air pollutant exposures, as affected by changes in ecosystem management and regulatory decisions. AMAD is responsible for providing a sound scientific and technical basis for regulatory policies based on air quality models to improve ambient air quality. The models developed by AMAD are being used by EPA, NOAA, and the air pollution community in understanding and forecasting not only the magnitude of the air pollution problem, but also in developing emission control policies and regulations for air quality improvements.

7 CFR 3.79 - Review of USDA records related to the debt.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Review of USDA records related to the debt. 3.79....79 Review of USDA records related to the debt. (a) Notification by employee. An employee who intends to inspect or copy USDA records related to the debt must send a letter to USDA stating his or her...

7 CFR 3.79 - Review of USDA records related to the debt.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Review of USDA records related to the debt. 3.79....79 Review of USDA records related to the debt. (a) Notification by employee. An employee who intends to inspect or copy USDA records related to the debt must send a letter to USDA stating his or her...

7 CFR 15f.2 - Who may use these procedures for processing their discrimination complaint with USDA?

Code of Federal Regulations, 2013 CFR

2013-01-01

... discrimination complaint with USDA? 15f.2 Section 15f.2 Agriculture Office of the Secretary of Agriculture... USDA? A person may use these procedures if he or she filed a nonemployment related discrimination complaint with USDA prior to July 1, 1997, that alleged discrimination by USDA at any time during the period...

7 CFR 15f.2 - Who may use these procedures for processing their discrimination complaint with USDA?

Code of Federal Regulations, 2011 CFR

2011-01-01

... discrimination complaint with USDA? 15f.2 Section 15f.2 Agriculture Office of the Secretary of Agriculture... USDA? A person may use these procedures if he or she filed a nonemployment related discrimination complaint with USDA prior to July 1, 1997, that alleged discrimination by USDA at any time during the period...

7 CFR 3.79 - Review of USDA records related to the debt.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Review of USDA records related to the debt. 3.79....79 Review of USDA records related to the debt. (a) Notification by employee. An employee who intends to inspect or copy USDA records related to the debt must send a letter to USDA stating his or her...

7 CFR 3.79 - Review of USDA records related to the debt.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Review of USDA records related to the debt. 3.79....79 Review of USDA records related to the debt. (a) Notification by employee. An employee who intends to inspect or copy USDA records related to the debt must send a letter to USDA stating his or her...

7 CFR 15f.2 - Who may use these procedures for processing their discrimination complaint with USDA?

Code of Federal Regulations, 2014 CFR

2014-01-01

... discrimination complaint with USDA? 15f.2 Section 15f.2 Agriculture Office of the Secretary of Agriculture... USDA? A person may use these procedures if he or she filed a nonemployment related discrimination complaint with USDA prior to July 1, 1997, that alleged discrimination by USDA at any time during the period...

7 CFR 15f.2 - Who may use these procedures for processing their discrimination complaint with USDA?

Code of Federal Regulations, 2012 CFR

2012-01-01

... discrimination complaint with USDA? 15f.2 Section 15f.2 Agriculture Office of the Secretary of Agriculture... USDA? A person may use these procedures if he or she filed a nonemployment related discrimination complaint with USDA prior to July 1, 1997, that alleged discrimination by USDA at any time during the period...

7 CFR 3.79 - Review of USDA records related to the debt.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Review of USDA records related to the debt. 3.79....79 Review of USDA records related to the debt. (a) Notification by employee. An employee who intends to inspect or copy USDA records related to the debt must send a letter to USDA stating his or her...

7 CFR 15f.2 - Who may use these procedures for processing their discrimination complaint with USDA?

Code of Federal Regulations, 2010 CFR

2010-01-01

... discrimination complaint with USDA? 15f.2 Section 15f.2 Agriculture Office of the Secretary of Agriculture... USDA? A person may use these procedures if he or she filed a nonemployment related discrimination complaint with USDA prior to July 1, 1997, that alleged discrimination by USDA at any time during the period...

Effect of Flooding and the nosZ Gene in Bradyrhizobia on Bradyrhizobial Community Structure in the Soil.

PubMed

Saeki, Yuichi; Nakamura, Misato; Mason, Maria Luisa T; Yano, Tsubasa; Shiro, Sokichi; Sameshima-Saito, Reiko; Itakura, Manabu; Minamisawa, Kiwamu; Yamamoto, Akihiro

2017-06-24

We investigated the effects of the water status (flooded or non-flooded) and presence of the nosZ gene in bradyrhizobia on the bradyrhizobial community structure in a factorial experiment that examined three temperature levels (20°C, 25°C, and 30°C) and two soil types (andosol and gray lowland soil) using microcosm incubations. All microcosms were inoculated with Bradyrhizobium japonicum USDA6 T , B. japonicum USDA123, and B. elkanii USDA76 T , which do not possess the nosZ gene, and then half received B. diazoefficiens USDA110 T wt (wt for the wild-type) and the other half received B. diazoefficiens USDA110ΔnosZ. USDA110 T wt possesses the nosZ gene, which encodes N 2 O reductase; 110ΔnosZ, a mutant variant, does not. Changes in the community structure after 30- and 60-d incubations were investigated by denaturing-gradient gel electrophoresis and an image analysis. USDA6 T and 76 T strains slightly increased in non-flooded soil regardless of which USDA110 T strain was present. In flooded microcosms with the USDA110 T wt strain, USDA110 T wt became dominant, whereas in microcosms with the USDA110ΔnosZ, a similar change in the community structure occurred to that in non-flooded microcosms. These results suggest that possession of the nosZ gene confers a competitive advantage to B. diazoefficiens USDA110 T in flooded soil. We herein demonstrated that the dominance of B. diazoefficiens USDA110 T wt within the soil bradyrhizobial population may be enhanced by periods of flooding or waterlogging systems such as paddy-soybean rotations because it appears to have the ability to thrive in moderately anaerobic soil.

Further evidence that a terminal drought tolerance QTL of pearl millet is associated with reduced salt uptake

PubMed Central

Sharma, Parbodh C.; Singh, Dhananjay; Sehgal, Deepmala; Singh, Gurbachan; Hash, C.T.; Yadav, Rattan S.

2014-01-01

Earlier, we established that a major drought tolerance QTL on linkage group 2 of pearl millet is also associated with reduced salt uptake and enhanced growth under salt stress. Present study was undertaken to re-assess the performance of drought tolerant (PRLT 2/89-33) and drought sensitive (H 77/833-2) parents along with two QTL-NILs (ICMR 01029 and ICMR 01040), under salinity stress specifically imposed during post-flowering growth stages when plants had developed their ion sinks in full. Time course changes in ionic accumulation and their compartmentalization in different plant parts was studied, specifically to monitor and capture changes conferred by the two alleles at this QTL, at small intervals. Amongst different plant parts, higher accumulation of toxic ion Na+ was recorded in roots. Further, the Na+ concentration in roots of the testcross hybrid of the drought-sensitive parent (H 77/833-2) reached its maximum at ECiw 15 dS m−1 within 24 h after salinity imposition, whereas it continued to increase with time in the testcross hybrids of the drought tolerant parent PRLT 2/89-33 as well as those of its QTL-NILs (ICMR 01029 and ICMR 01004) and reached at its maximum at 120 h stage. Comparison of differential distribution of toxic ions in individual leaves revealed that Na+ ions were not uniformly distributed in the leaves of the drought-tolerant parent and drought-tolerant QTL-NILs; but accumulated preferentially in the older leaves, whereas the hybrid of the drought-sensitive parent showed significantly higher Na+ concentration in all main stem leaves irrespective of their age. Dynamics of chlorophyll and proline concentration variation studied under salt stress at late flowering stages revealed a greater reduction, almost twice, in both leaf chlorophyll and proline concentrations in younger leaves in the hybrids of the sensitive parent as compared to the tolerant parent and QTL NILs. Imposition of salinity stress even at flowering stage affected the yield performance in pearl millet, wherein higher yield was recorded in drought tolerant parent and the two QTL-NILs compared to drought sensitive parent. PMID:24895469

Factors influencing general practitioners' decisions about cardiovascular disease risk reassessment: findings from experimental and interview studies.

PubMed

McKinn, Shannon; Bonner, Carissa; Jansen, Jesse; Teixeira-Pinto, Armando; So, Matthew; Irwig, Les; Doust, Jenny; Glasziou, Paul; McCaffery, Kirsten

2016-08-05

Guidelines on cardiovascular disease (CVD) risk reassessment intervals are unclear, potentially leading to detrimental practice variation: too frequent can result in overtreatment and greater strain on the healthcare system; too infrequent could result in the neglect of high risk patients who require medication. This study aimed to understand the different factors that general practitioners (GPs) consider when deciding on the reassessment interval for patients previously assessed for primary CVD risk. This paper combines quantitative and qualitative data regarding reassessment intervals from two separate studies of CVD risk management. Experimental study: 144 Australian GPs viewed a random selection of hypothetical cases via a paper-based questionnaire, in which blood pressure, cholesterol and 5-year absolute risk (AR) were systematically varied to appear lower or higher. GPs were asked how they would manage each case, including an open-ended response for when they would reassess the patient. Interview study: Semi-structured interviews were conducted with a purposive sample of 25 Australian GPs, recruited separately from the GPs in the experimental study. Transcribed audio-recordings were thematically coded, using the Framework Analysis method. GPs stated that they would reassess the majority of patients across all absolute risk categories in 6 months or less (low AR = 52 % [CI95% = 47-57 %], moderate AR = 82 % [CI95% = 76-86 %], high AR = 87 % [CI95% = 82-90 %], total = 71 % [CI95% = 67-75 %]), with 48 % (CI95% = 43-53 %) of patients reassessed in under 3 months. The majority (75 % [CI95% = 70-79 %]) of patients with low-moderate AR (≤15 %) and an elevated risk factor would be reassessed in under 6 months. Interviews: GPs identified different functions for reassessment and risk factor monitoring, which affected recommended intervals. These included perceived psychosocial benefits to patients, preparing the patient for medication, and identifying barriers to lifestyle change and medication adherence. Reassessment and monitoring intervals were driven by patient motivation to change lifestyle, patient demand, individual risk factors, and GP attitudes. There is substantial variation in reassessment intervals for patients with the same risk profile. This suggests that GPs are not following reassessment recommendations in the Australian guidelines. The use of shorter intervals for low-moderate AR contradicts research on optimal monitoring intervals, and may result in unnecessary costs and over-treatment.

40 CFR 180.448 - Hexythiazox; tolerance for residues.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Corn, sweet, plus cobs with husks removed (K+CWHR) 0.02 12/31/12 Corn, sweet, forage 6.0 12/31/12 Corn... only) 4.0 Corn, sweet, kernel plus cob with husks removed (EPA Regions 7-12 only) 0.1 Cotton, gin... byproducts 0.5 Citrus, dried pulp 0.60 Citrus, oil 24 Corn, field, forage 3.0 Corn, field, grain 0.02 Corn...

40 CFR 180.448 - Hexythiazox; tolerance for residues.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., sweet, plus cobs with husks removed (K+CWHR) 0.02 12/31/12 Corn, sweet, forage 6.0 12/31/12 Corn, sweet... only) 4.0 Corn, sweet, kernel plus cob with husks removed (EPA Regions 7-12 only) 0.1 Cotton, gin... 24 Corn, field, forage 3.0 Corn, field, grain 0.02 Corn, field, stover 7.0 Date, dried fruit 1.0 Egg...

40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

Code of Federal Regulations, 2013 CFR

2013-07-01

... tolerance range. The pressure in the sample cell must be the same with the calibration gas flowing during... this chapter. The check is done at 30 mph (48 kph), and a power absorption load setting to generate a... in § 85.2225(c)(1) are not met. (2) Leak checks. Each time the sample line integrity is broken, a...

40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

Code of Federal Regulations, 2011 CFR

2011-07-01

... tolerance range. The pressure in the sample cell must be the same with the calibration gas flowing during... this chapter. The check is done at 30 mph (48 kph), and a power absorption load setting to generate a... in § 85.2225(c)(1) are not met. (2) Leak checks. Each time the sample line integrity is broken, a...

40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

Code of Federal Regulations, 2012 CFR

2012-07-01

... tolerance range. The pressure in the sample cell must be the same with the calibration gas flowing during... this chapter. The check is done at 30 mph (48 kph), and a power absorption load setting to generate a... in § 85.2225(c)(1) are not met. (2) Leak checks. Each time the sample line integrity is broken, a...

78 FR 14461 - Fenpyrazamine; Pesticide Tolerances

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... berry subgroup 13-07G at 3.0 ppm (PP 1F7841); pistachio at 0.02 ppm; Caneberry subgroup 13-07A at 7.0..., Bushberry Subgroup 13-07B, Caneberry Subgroup 13-07A, Ginseng, and Pistachio'' in docket ID number EPA-HQ..., hulls at 1.5 ppm; pistachio at 0.02 ppm; lettuce, head at 1.5 ppm; lettuce, leaf at 2 ppm; Caneberry...

75 FR 4292 - 2-Propenoic acid, 2-ethylhexyl ester, polymer with ethenylbenzene and 2-methylpropyl 2-methyl-2...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... of pesticide use in residential settings. If EPA is able to determine that a finite tolerance is not... elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d)(2)(ii). 4. The...

75 FR 6583 - Poly(oxy-1,2-ethanediyl), α-hydro-ω-hydroxy-, polymer with 1, 1′-methylene-bis-[4...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... in residential settings. If EPA is able to determine that a finite tolerance is not necessary to... composition the atomic elements carbon, hydrogen, and oxygen. 3. The polymer does not contain as an integral part of its composition, except as impurities, any element other than those listed in 40 CFR 723.250(d...

Registration of cotton germplasm USDA MD 16-1 and USDA MD 16-2 with enhanced lint yield and fiber quality.

USDA-ARS?s Scientific Manuscript database

Upland cotton germplasm USDA MD 16-1 (Reg. No. __ and PI ___ ), and USDA MD 16-2 (Reg. No. ___ and PI___) (Gossypium hirsutum L.), have enhanced yield and good fiber quality. These germplasm lines were developed by the USDA-ARS, Stoneville, MS and released in 2017. Two crosses, MD 25-51 X MD 10-9-1 ...

Efflux mediated adaptive and cross resistance to ciprofloxacin and benzalkonium chloride in Pseudomonas aeruginosa of dairy origin.

PubMed

Pagedar, Ankita; Singh, Jitender; Batish, Virender K

2011-06-01

The present study was undertaken to investigate the role of efflux pump activity (EPA) in conferring adaptive and cross resistances against ciprofloxacin (CF) and benzalkonium chloride (BC) in dairy isolates of Pseudomonas aeruginosa. Biofilm formation potential was correlated with development of adaptive resistance in originally resistant strains. Irrespective of parent strains's susceptibility, isolates developed substantial adaptive resistance against CF and BC. Significant difference was observed in ability of non resistant isolates to develop adaptive resistance against CF and BC (P < 0.02) and subsequent cross resistance. EPA was quantified using EtBr (Ethidium Bromide) model and its role was more prominent [confirmed by its inhibition using efflux pump inhibitor (EPI) 2,4-dinitrophenol (DNP)], in conferring adaptive resistance (P = 0.147) than cross resistance (P = 0.343). Reduction in adaptive resistances due to EPI was more evident in originally non resistant strains, which reaffirms EPA as probable mechanism of adaptive resistance. The present study perhaps first of its kind, suggests an active role of EPA in conferring adaptive and cross resistances in food related P. aeruginosa isolates and supports reverse hypothesis that antibiotic-resistant organisms eventually become tolerant to other antibacterial agents as well. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

7 CFR 15f.5 - How do I request that USDA consider my complaint under these procedures?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false How do I request that USDA consider my complaint under... UNDER SECTION 741 I Filed a Complaint With USDA Prior to July 1, 1997, How Do I Request That USDA Consider My Complaint Using These Procedures? § 15f.5 How do I request that USDA consider my complaint...

7 CFR 15f.5 - How do I request that USDA consider my complaint under these procedures?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false How do I request that USDA consider my complaint under... UNDER SECTION 741 I Filed a Complaint With USDA Prior to July 1, 1997, How Do I Request That USDA Consider My Complaint Using These Procedures? § 15f.5 How do I request that USDA consider my complaint...

7 CFR 15f.5 - How do I request that USDA consider my complaint under these procedures?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false How do I request that USDA consider my complaint under... UNDER SECTION 741 I Filed a Complaint With USDA Prior to July 1, 1997, How Do I Request That USDA Consider My Complaint Using These Procedures? § 15f.5 How do I request that USDA consider my complaint...

7 CFR 15f.5 - How do I request that USDA consider my complaint under these procedures?

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false How do I request that USDA consider my complaint under... UNDER SECTION 741 I Filed a Complaint With USDA Prior to July 1, 1997, How Do I Request That USDA Consider My Complaint Using These Procedures? § 15f.5 How do I request that USDA consider my complaint...

7 CFR 15f.5 - How do I request that USDA consider my complaint under these procedures?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false How do I request that USDA consider my complaint under... UNDER SECTION 741 I Filed a Complaint With USDA Prior to July 1, 1997, How Do I Request That USDA Consider My Complaint Using These Procedures? § 15f.5 How do I request that USDA consider my complaint...

7 CFR 1.210 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Secretary of Agriculture ADMINISTRATIVE REGULATIONS Appearance of USDA Employees as Witnesses in Judicial or Administrative Proceedings § 1.210 Purpose. This subpart sets forth procedures governing the appearance of USDA... employment with USDA. These regulations do not apply to appearances by USDA employees as witnesses in...

7 CFR 1.210 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Secretary of Agriculture ADMINISTRATIVE REGULATIONS Appearance of USDA Employees as Witnesses in Judicial or Administrative Proceedings § 1.210 Purpose. This subpart sets forth procedures governing the appearance of USDA... employment with USDA. These regulations do not apply to appearances by USDA employees as witnesses in...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 1.210 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Secretary of Agriculture ADMINISTRATIVE REGULATIONS Appearance of USDA Employees as Witnesses in Judicial or Administrative Proceedings § 1.210 Purpose. This subpart sets forth procedures governing the appearance of USDA... employment with USDA. These regulations do not apply to appearances by USDA employees as witnesses in...

7 CFR 60.129 - USDA.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 3 2014-01-01 2014-01-01 false USDA. 60.129 Section 60.129 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... AND SHELLFISH General Provisions Definitions § 60.129 USDA. USDA means the United States Department of...

7 CFR 60.129 - USDA.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 3 2011-01-01 2011-01-01 false USDA. 60.129 Section 60.129 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... AND SHELLFISH General Provisions Definitions § 60.129 USDA. USDA means the United States Department of...

7 CFR 1.210 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Secretary of Agriculture ADMINISTRATIVE REGULATIONS Appearance of USDA Employees as Witnesses in Judicial or Administrative Proceedings § 1.210 Purpose. This subpart sets forth procedures governing the appearance of USDA... employment with USDA. These regulations do not apply to appearances by USDA employees as witnesses in...

7 CFR 1.210 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Secretary of Agriculture ADMINISTRATIVE REGULATIONS Appearance of USDA Employees as Witnesses in Judicial or Administrative Proceedings § 1.210 Purpose. This subpart sets forth procedures governing the appearance of USDA... employment with USDA. These regulations do not apply to appearances by USDA employees as witnesses in...

7 CFR 60.129 - USDA.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false USDA. 60.129 Section 60.129 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... AND SHELLFISH General Provisions Definitions § 60.129 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 3 2012-01-01 2012-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

7 CFR 60.129 - USDA.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false USDA. 60.129 Section 60.129 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... AND SHELLFISH General Provisions Definitions § 60.129 USDA. USDA means the United States Department of...

7 CFR 65.265 - USDA.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 3 2013-01-01 2013-01-01 false USDA. 65.265 Section 65.265 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections..., AND GINSENG General Provisions Definitions § 65.265 USDA. USDA means the United States Department of...

Post-prandial glucose levels and consumption of omega 3 fatty acids and saturated fats among two rural populations in Kenya.

PubMed

Wanjihia, V W; Kiplamai, F K; Waudo, J N; Boit, M K

2009-06-01

Amount and quality of dietary fat modifies glucose tolerance. Omega 3 Fatty Acids (n-3F A) are polyunsaturated fats, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found primarily in fish and they have a positive effect on glucose tolerance. To compare risk of type 2 diabetes mellitus (T2DM), as demonstrated thourough impaired glucose tolerance (IGT), and n-3FA intake among two rural populations. A descriptive, cross-sectional comparative study. Bondo District (Luo Community) and Kericho District (Kipsigis Community) of the Lake Victoria basin of Kenya. Sample of 150 individuals, aged above 18 years was randomly selected from each of the two communities. Impaired glucose tolerance (IGT) was measured according to World Health Organisation diagnostic criteria. The intake of n-3FA was determined using a 24 hour dietary recall and food frequency schedule. Data was analysed using SPSS and Pearson Correlation Coefficient was used to test correlation between n-3FA consumption and IGT. The inter-group comparisons were done using the t-test and analysis of variance. The prevalence of IGT was 11.8% among the Kipsigis and 4.8% among the Luo (P<0.001). The mean EPA and DHA intake was found to be 0.29 g/day and 0.34 g/day respectively among the Luo and 0.01 g/day and 0.01 g/day among the Kipsigis (P<0.001). The relationship between 2 hour post-prandial glucose level and consumption of DHA was (r=-0.111, p<0.05), EPA (r=-0.123, p<0.05), polyunsaturated fatty acids (r=-0.128, p<0.05) and saturated fats (r=-0.002, p=0.973). The levels of IGT were significantly lower (P<0.001) among the Luo, than among the Kipsigis. There was also evidence of significant inverse relationship between IGT and consumption of n-3FA and polyunsaturated fatty acids (PUFA) but no association between saturated fats intake and IGT. The saturated fat ingested did not affect the level of post-prandial glucose. The Luo who consumed higher n-3FA amounts, recorded lower levels of IGT than the Kipsigis who had significantly lower consumption. Effective screening methods should be used at the existing health units to determine risk factors of type 2 diabetes mellitus like IGT among patients. This could help in advising them accordingly on lifestyle changes, especially concerning diet and beneficial fats.

49 CFR 192.941 - What is a low stress reassessment?

Code of Federal Regulations, 2014 CFR

2014-10-01

... Management § 192.941 What is a low stress reassessment? (a) General. An operator of a transmission line that... 49 Transportation 3 2014-10-01 2014-10-01 false What is a low stress reassessment? 192.941 Section... actions to address external corrosion on the low stress covered segment. (1) Cathodically protected pipe...

49 CFR 192.941 - What is a low stress reassessment?

Code of Federal Regulations, 2011 CFR

2011-10-01

... Management § 192.941 What is a low stress reassessment? (a) General. An operator of a transmission line that... 49 Transportation 3 2011-10-01 2011-10-01 false What is a low stress reassessment? 192.941 Section... actions to address external corrosion on the low stress covered segment. (1) Cathodically protected pipe...

49 CFR 192.941 - What is a low stress reassessment?

Code of Federal Regulations, 2012 CFR

2012-10-01

... Management § 192.941 What is a low stress reassessment? (a) General. An operator of a transmission line that... 49 Transportation 3 2012-10-01 2012-10-01 false What is a low stress reassessment? 192.941 Section... actions to address external corrosion on the low stress covered segment. (1) Cathodically protected pipe...